{"HALLMARK_ALLOGRAFT_REJECTION": "Genes up-regulated during transplant rejection.", "HALLMARK_APICAL_SURFACE": "Genes encoding proteins over-represented on the apical surface of epithelial cells, e.g., important for cell polarity (apical area).", "HALLMARK_ADIPOGENESIS": "Genes up-regulated during adipocyte differentiation (adipogenesis).", "HALLMARK_COAGULATION": "Genes encoding components of blood coagulation system; also up-regulated in platelets.", "HALLMARK_APICAL_JUNCTION": "Genes encoding components of apical junction complex.", "HALLMARK_BILE_ACID_METABOLISM": "Genes involve in metabolism of bile acids and salts.", "HALLMARK_ANGIOGENESIS": "Genes up-regulated during formation of blood vessels (angiogenesis).", "HALLMARK_ANDROGEN_RESPONSE": "Genes defining response to androgens.", "HALLMARK_APOPTOSIS": "Genes mediating programmed cell death (apoptosis) by activation of caspases.", "HALLMARK_CHOLESTEROL_HOMEOSTASIS": "Genes involved in cholesterol homeostasis.", "HALLMARK_COMPLEMENT": "Genes encoding components of the complement system, which is part of the innate immune system.", "HALLMARK_ESTROGEN_RESPONSE_EARLY": "Genes defining early response to estrogen.", "HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION": "Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis.", "HALLMARK_HEDGEHOG_SIGNALING": "Genes up-regulated by activation of hedgehog signaling.", "HALLMARK_ESTROGEN_RESPONSE_LATE": "Genes defining late response to estrogen.", "HALLMARK_FATTY_ACID_METABOLISM": "Genes encoding proteins involved in metabolism of fatty acids.", "HALLMARK_DNA_REPAIR": "Genes involved in DNA repair.", "HALLMARK_E2F_TARGETS": "Genes encoding cell cycle related targets of E2F transcription factors.", "HALLMARK_GLYCOLYSIS": "Genes encoding proteins involved in glycolysis and gluconeogenesis.", "HALLMARK_G2M_CHECKPOINT": "Genes involved in the G2/M checkpoint, as in progression through the cell division cycle.", "HALLMARK_HEME_METABOLISM": "Genes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation.", "HALLMARK_HYPOXIA": "Genes up-regulated in response to low oxygen levels (hypoxia).", "HALLMARK_IL2_STAT5_SIGNALING": "Genes up-regulated by STAT5 in response to IL2 stimulation.", "HALLMARK_IL6_JAK_STAT3_SIGNALING": "Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response.", "HALLMARK_INFLAMMATORY_RESPONSE": "Genes defining inflammatory response.", "HALLMARK_INTERFERON_GAMMA_RESPONSE": "Genes up-regulated in response to IFNG [GeneID=3458].", "HALLMARK_INTERFERON_ALPHA_RESPONSE": "Genes up-regulated in response to alpha interferon proteins.", "HALLMARK_KRAS_SIGNALING_UP": "Genes up-regulated by KRAS activation.", "HALLMARK_MITOTIC_SPINDLE": "Genes important for mitotic spindle assembly.", "HALLMARK_KRAS_SIGNALING_DN": "Genes down-regulated by KRAS activation.", "HALLMARK_MTORC1_SIGNALING": "Genes up-regulated through activation of mTORC1 complex.", "HALLMARK_MYC_TARGETS_V2": "A subgroup of genes regulated by MYC - version 2 (v2).", "HALLMARK_MYC_TARGETS_V1": "A subgroup of genes regulated by MYC - version 1 (v1).", "HALLMARK_NOTCH_SIGNALING": "Genes up-regulated by activation of Notch signaling.", "HALLMARK_MYOGENESIS": "Genes involved in development of skeletal muscle (myogenesis).", "HALLMARK_OXIDATIVE_PHOSPHORYLATION": "Genes encoding proteins involved in oxidative phosphorylation.", "HALLMARK_PEROXISOME": "Genes encoding components of peroxisome.", "HALLMARK_PANCREAS_BETA_CELLS": "Genes specifically up-regulated in pancreatic beta cells.", "HALLMARK_P53_PATHWAY": "Genes involved in p53 pathways and networks.", "HALLMARK_PI3K_AKT_MTOR_SIGNALING": "Genes up-regulated by activation of the PI3K/AKT/mTOR pathway.", "HALLMARK_PROTEIN_SECRETION": "Genes involved in protein secretion pathway.", "HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY": "Genes up-regulated by reactive oxigen species (ROS).", "HALLMARK_TGF_BETA_SIGNALING": "Genes up-regulated in response to TGFB1 [GeneID=7040].", "HALLMARK_SPERMATOGENESIS": "Genes up-regulated during production of male gametes (sperm), as in spermatogenesis.", "HALLMARK_TNFA_SIGNALING_VIA_NFKB": "Genes regulated by NF-kB in response to TNF [GeneID=7124].", "HALLMARK_WNT_BETA_CATENIN_SIGNALING": "Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499].", "HALLMARK_UNFOLDED_PROTEIN_RESPONSE": "Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum.", "HALLMARK_UV_RESPONSE_UP": "Genes up-regulated in response to ultraviolet (UV) radiation.", "HALLMARK_UV_RESPONSE_DN": "Genes down-regulated in response to ultraviolet (UV) radiation.", "MT": "Ensembl 115 genes in cytogenetic band MT", "HALLMARK_XENOBIOTIC_METABOLISM": "Genes encoding proteins involved in processing of drugs and other xenobiotics.", "chr10p11": "Ensembl 115 genes in cytogenetic band chr10p11", "chr10p13": "Ensembl 115 genes in cytogenetic band chr10p13", "chr10p12": "Ensembl 115 genes in cytogenetic band chr10p12", "chr10p14": "Ensembl 115 genes in cytogenetic band chr10p14", "chr10p15": "Ensembl 115 genes in cytogenetic band chr10p15", "chr10q21": "Ensembl 115 genes in cytogenetic band chr10q21", "chr10q11": "Ensembl 115 genes in cytogenetic band chr10q11", "chr10q22": "Ensembl 115 genes in cytogenetic band chr10q22", "chr10q24": "Ensembl 115 genes in cytogenetic band chr10q24", "chr10q23": "Ensembl 115 genes in cytogenetic band chr10q23", "chr11p12": "Ensembl 115 genes in cytogenetic band chr11p12", "chr10q25": "Ensembl 115 genes in cytogenetic band chr10q25", "chr11p11": "Ensembl 115 genes in cytogenetic band chr11p11", "chr10q26": "Ensembl 115 genes in cytogenetic band chr10q26", "chr11p13": "Ensembl 115 genes in cytogenetic band chr11p13", "chr11p14": "Ensembl 115 genes in cytogenetic band chr11p14", "chr11q11": "Ensembl 115 genes in cytogenetic band chr11q11", "chr11p15": "Ensembl 115 genes in cytogenetic band chr11p15", "chr11q21": "Ensembl 115 genes in cytogenetic band chr11q21", "chr11q14": "Ensembl 115 genes in cytogenetic band chr11q14", "chr11q12": "Ensembl 115 genes in cytogenetic band chr11q12", "chr11q23": "Ensembl 115 genes in cytogenetic band chr11q23", "chr11q25": "Ensembl 115 genes in cytogenetic band chr11q25", "chr11q22": "Ensembl 115 genes in cytogenetic band chr11q22", "chr12p11": "Ensembl 115 genes in cytogenetic band chr12p11", "chr11q13": "Ensembl 115 genes in cytogenetic band chr11q13", "chr11q24": "Ensembl 115 genes in cytogenetic band chr11q24", "chr12p12": "Ensembl 115 genes in cytogenetic band chr12p12", "chr12q12": "Ensembl 115 genes in cytogenetic band chr12q12", "chr12q15": "Ensembl 115 genes in cytogenetic band chr12q15", "chr12q14": "Ensembl 115 genes in cytogenetic band chr12q14", "chr12q21": "Ensembl 115 genes in cytogenetic band chr12q21", "chr12q22": "Ensembl 115 genes in cytogenetic band chr12q22", "chr12p13": "Ensembl 115 genes in cytogenetic band chr12p13", "chr12q23": "Ensembl 115 genes in cytogenetic band chr12q23", "chr13q11": "Ensembl 115 genes in cytogenetic band chr13q11", "chr12q13": "Ensembl 115 genes in cytogenetic band chr12q13", "chr13q13": "Ensembl 115 genes in cytogenetic band chr13q13", "chr12q24": "Ensembl 115 genes in cytogenetic band chr12q24", "chr13q12": "Ensembl 115 genes in cytogenetic band chr13q12", "chr13q22": "Ensembl 115 genes in cytogenetic band chr13q22", "chr13q21": "Ensembl 115 genes in cytogenetic band chr13q21", "chr13q32": "Ensembl 115 genes in cytogenetic band chr13q32", "chr13q33": "Ensembl 115 genes in cytogenetic band chr13q33", "chr13q14": "Ensembl 115 genes in cytogenetic band chr13q14", "chr13q34": "Ensembl 115 genes in cytogenetic band chr13q34", "chr13q31": "Ensembl 115 genes in cytogenetic band chr13q31", "chr14q13": "Ensembl 115 genes in cytogenetic band chr14q13", "chr14q12": "Ensembl 115 genes in cytogenetic band chr14q12", "chr14q11": "Ensembl 115 genes in cytogenetic band chr14q11", "chr14q31": "Ensembl 115 genes in cytogenetic band chr14q31", "chr14q22": "Ensembl 115 genes in cytogenetic band chr14q22", "chr14q21": "Ensembl 115 genes in cytogenetic band chr14q21", "chr14q23": "Ensembl 115 genes in cytogenetic band chr14q23", "chr14q24": "Ensembl 115 genes in cytogenetic band chr14q24", "chr15q11": "Ensembl 115 genes in cytogenetic band chr15q11", "chr15q12": "Ensembl 115 genes in cytogenetic band chr15q12", "chr14q32": "Ensembl 115 genes in cytogenetic band chr14q32", "chr15q14": "Ensembl 115 genes in cytogenetic band chr15q14", "chr15q13": "Ensembl 115 genes in cytogenetic band chr15q13", "chr15q23": "Ensembl 115 genes in cytogenetic band chr15q23", "chr15q15": "Ensembl 115 genes in cytogenetic band chr15q15", "chr15q21": "Ensembl 115 genes in cytogenetic band chr15q21", "chr15q22": "Ensembl 115 genes in cytogenetic band chr15q22", "chr15q24": "Ensembl 115 genes in cytogenetic band chr15q24", "chr15q25": "Ensembl 115 genes in cytogenetic band chr15q25", "chr16q11": "Ensembl 115 genes in cytogenetic band chr16q11", "chr15q26": "Ensembl 115 genes in cytogenetic band chr15q26", "chr16p12": "Ensembl 115 genes in cytogenetic band chr16p12", "chr16p11": "Ensembl 115 genes in cytogenetic band chr16p11", "chr16q21": "Ensembl 115 genes in cytogenetic band chr16q21", "chr16q13": "Ensembl 115 genes in cytogenetic band chr16q13", "chr16p13": "Ensembl 115 genes in cytogenetic band chr16p13", "chr16q12": "Ensembl 115 genes in cytogenetic band chr16q12", "chr16q22": "Ensembl 115 genes in cytogenetic band chr16q22", "chr16q23": "Ensembl 115 genes in cytogenetic band chr16q23", "chr17p12": "Ensembl 115 genes in cytogenetic band chr17p12", "chr16q24": "Ensembl 115 genes in cytogenetic band chr16q24", "chr17p11": "Ensembl 115 genes in cytogenetic band chr17p11", "chr17q22": "Ensembl 115 genes in cytogenetic band chr17q22", "chr17q11": "Ensembl 115 genes in cytogenetic band chr17q11", "chr17q12": "Ensembl 115 genes in cytogenetic band chr17q12", "chr17p13": "Ensembl 115 genes in cytogenetic band chr17p13", "chr17q23": "Ensembl 115 genes in cytogenetic band chr17q23", "chr17q21": "Ensembl 115 genes in cytogenetic band chr17q21", "chr17q24": "Ensembl 115 genes in cytogenetic band chr17q24", "chr18p11": "Ensembl 115 genes in cytogenetic band chr18p11", "chr17q25": "Ensembl 115 genes in cytogenetic band chr17q25", "chr18q11": "Ensembl 115 genes in cytogenetic band chr18q11", "chr18q12": "Ensembl 115 genes in cytogenetic band chr18q12", "chr18q22": "Ensembl 115 genes in cytogenetic band chr18q22", "chr18q23": "Ensembl 115 genes in cytogenetic band chr18q23", "chr18q21": "Ensembl 115 genes in cytogenetic band chr18q21", "chr19p12": "Ensembl 115 genes in cytogenetic band chr19p12", "chr19q11": "Ensembl 115 genes in cytogenetic band chr19q11", "chr19q12": "Ensembl 115 genes in cytogenetic band chr19q12", "chr1p11": "Ensembl 115 genes in cytogenetic band chr1p11", "chr1p12": "Ensembl 115 genes in cytogenetic band chr1p12", "chr19p13": "Ensembl 115 genes in cytogenetic band chr19p13", "chr1p13": "Ensembl 115 genes in cytogenetic band chr1p13", "chr1p21": "Ensembl 115 genes in cytogenetic band chr1p21", "chr1p32": "Ensembl 115 genes in cytogenetic band chr1p32", "chr1p22": "Ensembl 115 genes in cytogenetic band chr1p22", "chr19q13": "Ensembl 115 genes in cytogenetic band chr19q13", "chr1p31": "Ensembl 115 genes in cytogenetic band chr1p31", "chr1p33": "Ensembl 115 genes in cytogenetic band chr1p33", "chr1p35": "Ensembl 115 genes in cytogenetic band chr1p35", "chr1p34": "Ensembl 115 genes in cytogenetic band chr1p34", "chr1q22": "Ensembl 115 genes in cytogenetic band chr1q22", "chr1q31": "Ensembl 115 genes in cytogenetic band chr1q31", "chr1q21": "Ensembl 115 genes in cytogenetic band chr1q21", "chr1q25": "Ensembl 115 genes in cytogenetic band chr1q25", "chr1p36": "Ensembl 115 genes in cytogenetic band chr1p36", "chr1q24": "Ensembl 115 genes in cytogenetic band chr1q24", "chr1q23": "Ensembl 115 genes in cytogenetic band chr1q23", "chr1q32": "Ensembl 115 genes in cytogenetic band chr1q32", "chr1q43": "Ensembl 115 genes in cytogenetic band chr1q43", "chr1q41": "Ensembl 115 genes in cytogenetic band chr1q41", "chr1q42": "Ensembl 115 genes in cytogenetic band chr1q42", "chr1q44": "Ensembl 115 genes in cytogenetic band chr1q44", "chr20q12": "Ensembl 115 genes in cytogenetic band chr20q12", "chr20p12": "Ensembl 115 genes in cytogenetic band chr20p12", "chr20p11": "Ensembl 115 genes in cytogenetic band chr20p11", "chr20p13": "Ensembl 115 genes in cytogenetic band chr20p13", "chr21p12": "Ensembl 115 genes in cytogenetic band chr21p12", "chr21p11": "Ensembl 115 genes in cytogenetic band chr21p11", "chr20q11": "Ensembl 115 genes in cytogenetic band chr20q11", "chr21q11": "Ensembl 115 genes in cytogenetic band chr21q11", "chr20q13": "Ensembl 115 genes in cytogenetic band chr20q13", "chr22p11": "Ensembl 115 genes in cytogenetic band chr22p11", "chr21q21": "Ensembl 115 genes in cytogenetic band chr21q21", "chr2p12": "Ensembl 115 genes in cytogenetic band chr2p12", "chr21q22": "Ensembl 115 genes in cytogenetic band chr21q22", "chr22q12": "Ensembl 115 genes in cytogenetic band chr22q12", "chr22q11": "Ensembl 115 genes in cytogenetic band chr22q11", "chr22q13": "Ensembl 115 genes in cytogenetic band chr22q13", "chr2p13": "Ensembl 115 genes in cytogenetic band chr2p13", "chr2p11": "Ensembl 115 genes in cytogenetic band chr2p11", "chr2p14": "Ensembl 115 genes in cytogenetic band chr2p14", "chr2p15": "Ensembl 115 genes in cytogenetic band chr2p15", "chr2p16": "Ensembl 115 genes in cytogenetic band chr2p16", "chr2p21": "Ensembl 115 genes in cytogenetic band chr2p21", "chr2p22": "Ensembl 115 genes in cytogenetic band chr2p22", "chr2p23": "Ensembl 115 genes in cytogenetic band chr2p23", "chr2q12": "Ensembl 115 genes in cytogenetic band chr2q12", "chr2p24": "Ensembl 115 genes in cytogenetic band chr2p24", "chr2q13": "Ensembl 115 genes in cytogenetic band chr2q13", "chr2p25": "Ensembl 115 genes in cytogenetic band chr2p25", "chr2q11": "Ensembl 115 genes in cytogenetic band chr2q11", "chr2q14": "Ensembl 115 genes in cytogenetic band chr2q14", "chr2q22": "Ensembl 115 genes in cytogenetic band chr2q22", "chr2q21": "Ensembl 115 genes in cytogenetic band chr2q21", "chr2q23": "Ensembl 115 genes in cytogenetic band chr2q23", "chr2q24": "Ensembl 115 genes in cytogenetic band chr2q24", "chr2q31": "Ensembl 115 genes in cytogenetic band chr2q31", "chr2q32": "Ensembl 115 genes in cytogenetic band chr2q32", "chr2q34": "Ensembl 115 genes in cytogenetic band chr2q34", "chr2q36": "Ensembl 115 genes in cytogenetic band chr2q36", "chr2q33": "Ensembl 115 genes in cytogenetic band chr2q33", "chr3p11": "Ensembl 115 genes in cytogenetic band chr3p11", "chr2q35": "Ensembl 115 genes in cytogenetic band chr2q35", "chr2q37": "Ensembl 115 genes in cytogenetic band chr2q37", "chr3p12": "Ensembl 115 genes in cytogenetic band chr3p12", "chr3p13": "Ensembl 115 genes in cytogenetic band chr3p13", "chr3p23": "Ensembl 115 genes in cytogenetic band chr3p23", "chr3p14": "Ensembl 115 genes in cytogenetic band chr3p14", "chr3p22": "Ensembl 115 genes in cytogenetic band chr3p22", "chr3p21": "Ensembl 115 genes in cytogenetic band chr3p21", "chr3p24": "Ensembl 115 genes in cytogenetic band chr3p24", "chr3p26": "Ensembl 115 genes in cytogenetic band chr3p26", "chr3q11": "Ensembl 115 genes in cytogenetic band chr3q11", "chr3p25": "Ensembl 115 genes in cytogenetic band chr3p25", "chr3q12": "Ensembl 115 genes in cytogenetic band chr3q12", "chr3q13": "Ensembl 115 genes in cytogenetic band chr3q13", "chr3q21": "Ensembl 115 genes in cytogenetic band chr3q21", "chr3q22": "Ensembl 115 genes in cytogenetic band chr3q22", "chr3q23": "Ensembl 115 genes in cytogenetic band chr3q23", "chr3q24": "Ensembl 115 genes in cytogenetic band chr3q24", "chr3q28": "Ensembl 115 genes in cytogenetic band chr3q28", "chr3q27": "Ensembl 115 genes in cytogenetic band chr3q27", "chr3q29": "Ensembl 115 genes in cytogenetic band chr3q29", "chr4p11": "Ensembl 115 genes in cytogenetic band chr4p11", "chr3q25": "Ensembl 115 genes in cytogenetic band chr3q25", "chr3q26": "Ensembl 115 genes in cytogenetic band chr3q26", "chr4p12": "Ensembl 115 genes in cytogenetic band chr4p12", "chr4p13": "Ensembl 115 genes in cytogenetic band chr4p13", "chr4p14": "Ensembl 115 genes in cytogenetic band chr4p14", "chr4p15": "Ensembl 115 genes in cytogenetic band chr4p15", "chr4q12": "Ensembl 115 genes in cytogenetic band chr4q12", "chr4p16": "Ensembl 115 genes in cytogenetic band chr4p16", "chr4q21": "Ensembl 115 genes in cytogenetic band chr4q21", "chr4q13": "Ensembl 115 genes in cytogenetic band chr4q13", "chr4q23": "Ensembl 115 genes in cytogenetic band chr4q23", "chr4q27": "Ensembl 115 genes in cytogenetic band chr4q27", "chr4q22": "Ensembl 115 genes in cytogenetic band chr4q22", "chr4q24": "Ensembl 115 genes in cytogenetic band chr4q24", "chr4q25": "Ensembl 115 genes in cytogenetic band chr4q25", "chr4q26": "Ensembl 115 genes in cytogenetic band chr4q26", "chr4q28": "Ensembl 115 genes in cytogenetic band chr4q28", "chr4q31": "Ensembl 115 genes in cytogenetic band chr4q31", "chr4q33": "Ensembl 115 genes in cytogenetic band chr4q33", "chr4q32": "Ensembl 115 genes in cytogenetic band chr4q32", "chr4q34": "Ensembl 115 genes in cytogenetic band chr4q34", "chr5p12": "Ensembl 115 genes in cytogenetic band chr5p12", "chr4q35": "Ensembl 115 genes in cytogenetic band chr4q35", "chr5p14": "Ensembl 115 genes in cytogenetic band chr5p14", "chr5p13": "Ensembl 115 genes in cytogenetic band chr5p13", "chr5p15": "Ensembl 115 genes in cytogenetic band chr5p15", "chr5q11": "Ensembl 115 genes in cytogenetic band chr5q11", "chr5q12": "Ensembl 115 genes in cytogenetic band chr5q12", "chr5q13": "Ensembl 115 genes in cytogenetic band chr5q13", "chr5q14": "Ensembl 115 genes in cytogenetic band chr5q14", "chr5q32": "Ensembl 115 genes in cytogenetic band chr5q32", "chr5q21": "Ensembl 115 genes in cytogenetic band chr5q21", "chr5q15": "Ensembl 115 genes in cytogenetic band chr5q15", "chr5q31": "Ensembl 115 genes in cytogenetic band chr5q31", "chr5q34": "Ensembl 115 genes in cytogenetic band chr5q34", "chr6p11": "Ensembl 115 genes in cytogenetic band chr6p11", "chr5q22": "Ensembl 115 genes in cytogenetic band chr5q22", "chr5q23": "Ensembl 115 genes in cytogenetic band chr5q23", "chr5q33": "Ensembl 115 genes in cytogenetic band chr5q33", "chr5q35": "Ensembl 115 genes in cytogenetic band chr5q35", "chr6p23": "Ensembl 115 genes in cytogenetic band chr6p23", "chr6p12": "Ensembl 115 genes in cytogenetic band chr6p12", "chr6q11": "Ensembl 115 genes in cytogenetic band chr6q11", "chr6p21": "Ensembl 115 genes in cytogenetic band chr6p21", "chr6q12": "Ensembl 115 genes in cytogenetic band chr6q12", "chr6p24": "Ensembl 115 genes in cytogenetic band chr6p24", "chr6p22": "Ensembl 115 genes in cytogenetic band chr6p22", "chr6q13": "Ensembl 115 genes in cytogenetic band chr6q13", "chr6p25": "Ensembl 115 genes in cytogenetic band chr6p25", "chr6q14": "Ensembl 115 genes in cytogenetic band chr6q14", "chr6q15": "Ensembl 115 genes in cytogenetic band chr6q15", "chr6q16": "Ensembl 115 genes in cytogenetic band chr6q16", "chr6q21": "Ensembl 115 genes in cytogenetic band chr6q21", "chr6q24": "Ensembl 115 genes in cytogenetic band chr6q24", "chr6q26": "Ensembl 115 genes in cytogenetic band chr6q26", "chr6q23": "Ensembl 115 genes in cytogenetic band chr6q23", "chr6q22": "Ensembl 115 genes in cytogenetic band chr6q22", "chr6q27": "Ensembl 115 genes in cytogenetic band chr6q27", "chr6q25": "Ensembl 115 genes in cytogenetic band chr6q25", "chr7p11": "Ensembl 115 genes in cytogenetic band chr7p11", "chr7p13": "Ensembl 115 genes in cytogenetic band chr7p13", "chr7p12": "Ensembl 115 genes in cytogenetic band chr7p12", "chr7p14": "Ensembl 115 genes in cytogenetic band chr7p14", "chr7p15": "Ensembl 115 genes in cytogenetic band chr7p15", "chr7p22": "Ensembl 115 genes in cytogenetic band chr7p22", "chr7p21": "Ensembl 115 genes in cytogenetic band chr7p21", "chr7q11": "Ensembl 115 genes in cytogenetic band chr7q11", "chr7q33": "Ensembl 115 genes in cytogenetic band chr7q33", "chr7q31": "Ensembl 115 genes in cytogenetic band chr7q31", "chr7q21": "Ensembl 115 genes in cytogenetic band chr7q21", "chr7q22": "Ensembl 115 genes in cytogenetic band chr7q22", "chr7q32": "Ensembl 115 genes in cytogenetic band chr7q32", "chr7q35": "Ensembl 115 genes in cytogenetic band chr7q35", "chr7q34": "Ensembl 115 genes in cytogenetic band chr7q34", "chr8p11": "Ensembl 115 genes in cytogenetic band chr8p11", "chr7q36": "Ensembl 115 genes in cytogenetic band chr7q36", "chr8p12": "Ensembl 115 genes in cytogenetic band chr8p12", "chr8p21": "Ensembl 115 genes in cytogenetic band chr8p21", "chr8p22": "Ensembl 115 genes in cytogenetic band chr8p22", "chr8q11": "Ensembl 115 genes in cytogenetic band chr8q11", "chr8q12": "Ensembl 115 genes in cytogenetic band chr8q12", "chr8q13": "Ensembl 115 genes in cytogenetic band chr8q13", "chr8p23": "Ensembl 115 genes in cytogenetic band chr8p23", "chr8q21": "Ensembl 115 genes in cytogenetic band chr8q21", "chr8q23": "Ensembl 115 genes in cytogenetic band chr8q23", "chr9p12": "Ensembl 115 genes in cytogenetic band chr9p12", "chr8q22": "Ensembl 115 genes in cytogenetic band chr8q22", "chr9p11": "Ensembl 115 genes in cytogenetic band chr9p11", "chr9p22": "Ensembl 115 genes in cytogenetic band chr9p22", "chr9p13": "Ensembl 115 genes in cytogenetic band chr9p13", "chr9p23": "Ensembl 115 genes in cytogenetic band chr9p23", "chr9q12": "Ensembl 115 genes in cytogenetic band chr9q12", "chr9p24": "Ensembl 115 genes in cytogenetic band chr9p24", "chr9p21": "Ensembl 115 genes in cytogenetic band chr9p21", "chr8q24": "Ensembl 115 genes in cytogenetic band chr8q24", "chr9q13": "Ensembl 115 genes in cytogenetic band chr9q13", "chr9q21": "Ensembl 115 genes in cytogenetic band chr9q21", "chr9q22": "Ensembl 115 genes in cytogenetic band chr9q22", "chr9q32": "Ensembl 115 genes in cytogenetic band chr9q32", "chr9q31": "Ensembl 115 genes in cytogenetic band chr9q31", "chr9q33": "Ensembl 115 genes in cytogenetic band chr9q33", "chrXq11": "Ensembl 115 genes in cytogenetic band chrXq11", "chrXp21": "Ensembl 115 genes in cytogenetic band chrXp21", "chrXp11": "Ensembl 115 genes in cytogenetic band chrXp11", "chr9q34": "Ensembl 115 genes in cytogenetic band chr9q34", "chrXp22": "Ensembl 115 genes in cytogenetic band chrXp22", "chrXq12": "Ensembl 115 genes in cytogenetic band chrXq12", "chrXq13": "Ensembl 115 genes in cytogenetic band chrXq13", "chrXq23": "Ensembl 115 genes in cytogenetic band chrXq23", "chrXq24": "Ensembl 115 genes in cytogenetic band chrXq24", "chrXq22": "Ensembl 115 genes in cytogenetic band chrXq22", "chrXq21": "Ensembl 115 genes in cytogenetic band chrXq21", "chrXq25": "Ensembl 115 genes in cytogenetic band chrXq25", "chrXq27": "Ensembl 115 genes in cytogenetic band chrXq27", "chrXq26": "Ensembl 115 genes in cytogenetic band chrXq26", "chrYp11": "Ensembl 115 genes in cytogenetic band chrYp11", "chrXq28": "Ensembl 115 genes in cytogenetic band chrXq28", "chrYq12": "Ensembl 115 genes in cytogenetic band chrYq12", "ABBUD_LIF_SIGNALING_2_DN": "Genes down-regulated in GH3 cells (pituitary cancer) after treatment with LIF [GeneID=3976].", "ABBUD_LIF_SIGNALING_2_UP": "Genes up-regulated in GH3 cells (pituitary cancer) after treatment with LIF [GeneID=3976].", "ABBUD_LIF_SIGNALING_1_DN": "Genes down-regulated in AtT20 cells (pituitary cancer) after  treatment with LIF [GeneID=3976].", "ABBUD_LIF_SIGNALING_1_UP": "Genes up-regulated in AtT20 cells (pituitary cancer) after  treatment with LIF [GeneID=3976].", "chrYq11": "Ensembl 115 genes in cytogenetic band chrYq11", "ABDELMOHSEN_ELAVL4_TARGETS": "Major ELAVL4 [GeneID=1996] associated mRNAs encoding proteins with functions in neuronal physiology.", "ABDULRAHMAN_KIDNEY_CANCER_VHL_DN": "Genes down-regulated in the RCC4 cells (renal cell carcinoma, RCC) expressing VHL [GeneID=7428] mutants Type 1 and 2B (associated with RCC) but not those of Type 2A and 2C (not associated with RCC).", "ABE_VEGFA_TARGETS": "Genes most profoundly induced in HUVEC cells (endothelium) by VEGFA [GeneID=7422].", "ABE_INNER_EAR": "Genes prefentially expressed in human inner ear tissue (cochlea and vestibule), at least 10-fold higher from a mixture of 29 other tissues.", "ABE_VEGFA_TARGETS_30MIN": "Genes up-regulated in HUVEC cells (endothelium) at 30 min after VEGFA [GeneID=7422] stimulation.", "ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP": "Genes up-regulated in immunoglobulin light chain amyloidosis plasma cells (ALPC) compared to multiple myeloma (MM) cells.", "ABE_VEGFA_TARGETS_2HR": "Genes up-regulated in HUVEC cells (endothelium) at 2 h after VEGFA [GeneID=7422] stimulation.", "ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_DN": "Genes down-regulated in immunoglobulin light chain amyloidosis plasma cells (ALPC) compared to multiple myeloma (MM) cells.", "ABRAMSON_INTERACT_WITH_AIRE": "Proteins interacting with AIRE [GeneID=326], based on massspectroscopy analysis of co-immunoprecipitates in 293T cells (embryonic kidney).", "ACEVEDO_LIVER_CANCER_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) compared to normal liver samples.", "ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN": "Genes whose promoters display lower levels of histone H3 trimethylation mark at K27 (H3K27me3) in hepatocellular carcinoma (HCC) compared to normal liver.", "ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP": "Genes whose promoters display higher levels of histone H3 trimethylation mark at K27 (H3K27me3) in hepatocellular carcinoma (HCC) compared to normal liver.", "ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_DN": "Genes whose promoters display lower histone H3 trimethylation mark at K9 (H3K9me3) in hepatocellular carcinoma (HCC) compared to normal liver.", "ACEVEDO_LIVER_CANCER_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) compared to normal liver samples.", "ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP": "Genes whose promoters display higher histone H3 trimethylation mark at K9 (H3K9me3) in hepatocellular carcinoma (HCC) compared to normal liver.", "ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN": "Genes down-regulated in liver tumor compared to the normal adjacent tissue.", "ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP": "Genes up-regulated in liver tumor compared to the normal adjacent tissue.", "ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN": "Genes down-regulated in normal tissue adjacent to liver tumor, compared to the normal liver samples.", "ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_DN": "Genes down-regulated in K562 cells (lymphoblast) by MYC [GeneID=4609] in the presence of CKN1B [GeneID=1027].", "ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_UP": "Genes up-regulated in K562 cells (lymphoblast) by MYC [GeneID=4609] in the presence of CKN1B [GeneID=1027].", "ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN": "Selected genes changed in K562 (immortalized erythroleukemia) cells induced by hemin [PubChem=26945] treatment to express erythroid properties.", "ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP": "Genes up-regulated in normal tissue adjacent to liver tumor, compared to the normal liver samples.", "ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN": "Genes whose DNA is hypo-methylated in hepatocellular carcinoma (HCC) compared to normal liver.", "AFFAR_YY1_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) expressing ~25% of YY1 [GeneID=7528].", "AGARWAL_AKT_PATHWAY_TARGETS": "Angiogenic and metastatic genes changed in RKO cells (colorectal cancer) upon perturbation of key components of AKT pathway.", "AFFAR_YY1_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) expressing ~25% of YY1 [GeneID=7528].", "AIYAR_COBRA1_TARGETS_UP": "Genes up-regulated in T47D cells (breast cancer) after COBRA1 [GeneID=25920] knockdown by RNAi.", "AIYAR_COBRA1_TARGETS_DN": "Genes down-regulated in T47D cells (breast cancer) after COBRA1 [GeneID=25920] knockdown by RNAi.", "AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN": "Down-regulated genes whose expression correlates with copy number losses in pancreatic adenocarcinoma cell lines and primary tumor specimens.", "AIGNER_ZEB1_TARGETS": "Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of ZEB1 [GeneID=6935] by RNAi.", "AKL_HTLV1_INFECTION_UP": "Genes up-regulated in WE17/10 cells (CD4+ [GeneID=920] T lymphocytes) infected by HTLV1 (and thus displaying low CD7 [GeneID=924]) compared to the uninfected (i.e., CD7+) cells.", "AKL_HTLV1_INFECTION_DN": "Genes down-regulated in WE17/10 cells (CD4+ [GeneID=920] T lymphocytes) infected by HTLV1 (and thus displaying low CD7 [GeneID=924]) compared to the uninfected (i.e., CD7+) cells.", "ALCALA_APOPTOSIS": "Genes able to induce cell death in an expression cDNA library screen.", "AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP": "Up-regulated genes whose expression correlates with copy number gains in pancreatic adenocarcinoma cell lines and primary tumor specimens.", "ALCALAY_AML_BY_NPM1_LOCALIZATION_UP": "Genes up-regulated in acute myeloid leukemia (AML) with respect to cellular localization of NPM1 [GeneID=4869]: cytoplasmic vs. nucleolar.", "ALCALAY_AML_BY_NPM1_LOCALIZATION_DN": "Genes down-regulated in acute myeloid leukemia (AML) with respect to cellular localization of NPM1 [GeneID=4869]: cytoplasmic vs. nucleolar.", "ALONSO_METASTASIS_EMT_DN": "EMT (epithelial-mesenchymal transition) genes down-regulated genes in melanoma tumous that developed metastatic disease compared to primary melanoma that did not.", "ALONSO_METASTASIS_DN": "Down-regulated genes in melanoma tumors that developed metastatic disease compared to primary melanoma that did not.", "ALONSO_METASTASIS_EMT_UP": "EMT (epithelial-mesenchymal transition) genes up-regulated genes in melanoma tumous that developed metastatic disease compared to primary melanoma that did not.", "ALONSO_METASTASIS_NEURAL_UP": "Neural-related genes up-regulated in melanoma tumors that developed metastases compared to primary melanoma that did not.", "ALFANO_MYC_TARGETS": "Genes up-regulated hT-RPE cells (immortalized retinal pigment epithelium) by MYC [GeneID=4609].", "ALTEMEIER_RESPONSE_TO_LPS_WITH_MECHANICAL_VENTILATION": "Genes up-regulated in lung tissue upon LPS aspiration with mechanical ventilation (MV) compared to control (PBS aspiration without MV).", "AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53": "Genes down-regulated by flavopiridol [PubChem=5287969] in the HCT116 cells (colon cancer) depending on their TP53 [GeneID=7157] status: wild-type vs loss of the gene's function (LOF).", "ALONSO_METASTASIS_UP": "Up-regulated genes in melanoma tumous that developed metastatic disease compared to primary melanoma that did not.", "AMIT_DELAYED_EARLY_GENES": "Delayed early genes (DEG) which are coordinately down-regulated in multiple epithelial tumor types.", "AMIT_EGF_RESPONSE_120_MCF10A": "Genes whose expression peaked at 120 min after stimulation of MCF10A cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_120_HELA": "Genes whose expression peaked at 120 min after stimulation of HeLa cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_20_HELA": "Genes whose expression peaked at 20 min after stimulation of HeLa cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_20_MCF10A": "Genes whose expression peaked at 20 min after stimulation of MCF10A cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_240_MCF10A": "Genes whose expression peaked at 240 min after stimulation of MCF10A cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_240_HELA": "Genes whose expression peaked at 240 min after stimulation of HeLa cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_40_MCF10A": "Genes whose expression peaked at 40 min after stimulation of MCF10A cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_40_HELA": "Genes whose expression peaked at 40 min after stimulation of HeLa cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_480_MCF10A": "Genes whose expression peaked at 480 min after stimulation of MCF10A cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_480_HELA": "Genes whose expression peaked at 480 min after stimulation of HeLa cells with EGF [GeneID=1950].", "AMIT_EGF_RESPONSE_60_HELA": "Genes whose expression peaked at 60 min after stimulation of HeLa cells with EGF [GeneID=1950].", "AMIT_SERUM_RESPONSE_20_MCF10A": "Genes whose expression peaked at 20 min after stimulation of MCF10A cells with serum.", "AMIT_EGF_RESPONSE_60_MCF10A": "Genes whose expression peaked at 60 min after stimulation of MCF10A cells with EGF [GeneID=1950].", "AMIT_SERUM_RESPONSE_120_MCF10A": "Genes whose expression peaked at 120 min after stimulation of MCF10A cells with serum.", "AMIT_SERUM_RESPONSE_40_MCF10A": "Genes whose expression peaked at 40 min after stimulation of MCF10A cells with serum.", "AMUNDSON_DNA_DAMAGE_RESPONSE_TP53": "Genes discriminating TP53 [GeneID=7157] status across various genotoxic stress agents.", "AMIT_SERUM_RESPONSE_480_MCF10A": "Genes whose expression peaked at 480 min after stimulation of MCF10A cells with serum.", "AMIT_SERUM_RESPONSE_240_MCF10A": "Genes whose expression peaked at 240 min after stimulation of MCF10A cells with serum.", "AMIT_SERUM_RESPONSE_60_MCF10A": "Genes whose expression peaked at 60 min after stimulation of MCF10A cells with serum.", "AMUNDSON_RESPONSE_TO_ARSENITE": "Genes discriminating responses to sodium arsenite [PubChem=26435] from other stresses.", "ANASTASSIOU_MULTICANCER_INVASIVENESS_SIGNATURE": "Invasiveness signature resulting from cancer cell/microenvironment interaction.", "ANDERSEN_CHOLANGIOCARCINOMA_CLASS1": "Genes overexpressed in cholangiocarcinoma class 1 associated with good prognosis", "APPEL_IMATINIB_RESPONSE": "Genes up-regulated by imatinib [PubChem=5291] during dendritic cell differentiation.", "ANDERSEN_LIVER_CANCER_KRT19_DN": "Genes under-expressed in KRT19-positive [GeneID=3880] hepatocellular carcinoma.", "ANDERSEN_LIVER_CANCER_KRT19_UP": "Genes over-expressed in KRT19-positive [GeneID=3880] hepatocellular carcinoma.", "ANDERSEN_CHOLANGIOCARCINOMA_CLASS2": "Genes overexpressed in cholangiocarcinoma class 2 associated with poor prognosis.", "APPIERTO_RESPONSE_TO_FENRETINIDE_UP": "Genes up-regulated in A2780 cells (ovarian carcinoma) exposed to fenretinide [PubChem=1744].", "APPIERTO_RESPONSE_TO_FENRETINIDE_DN": "Genes down-regulated in A2780 cells (ovarian carcinoma) exposed to fenretinide [PubChem=1744].", "APRELIKOVA_BRCA1_TARGETS": "Genes down-regulated in embryonic stem cells with BRCA1 [GeneID=672] loss of function (LOF).", "ASGHARZADEH_NEUROBLASTOMA_POOR_SURVIVAL_DN": "Down-regulated genes associated with poor survival prognosis of patients with metastatic neuroblastoma that lack MYCN [GeneID=4613] amplification.", "ASTIER_INTEGRIN_SIGNALING": "Integrin signaling signature in precursor B leukemia (PBL) cells:  fibronectin (FN1) [GeneID=2335] vs control treatment with poly-L-lysine.", "AUJLA_IL22_AND_IL17A_SIGNALING": "Genes changed in HBE cells (bronchial epithelium) after treatment with IL22 and IL17A [GeneID=50616;3605].", "ASTON_MAJOR_DEPRESSIVE_DISORDER_UP": "Genes up-regulated in the temporal cortex samples from patients with major depressive disorder.", "AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_DN": "Genes down-regulated in RWPE-1 cells (prostate cancer) upon expression of constitutively active form of STAT3 [GeneID=6774].", "ASTON_MAJOR_DEPRESSIVE_DISORDER_DN": "Genes down-regulated in the temporal cortex samples from patients with major depressive disorder.", "AUNG_GASTRIC_CANCER": "Selected genes specifically expressed in gastric cancer.", "AZARE_STAT3_TARGETS": "Genes up-regulated in RPWE-1 cells by activated STAT3 [GeneID=6774].", "BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_UP": "Genes up-regulated in D-341 MED (OBR) cells (medulloblastoma) resistant to both carmustine and O6-BG [PubChem=2578;4578].", "BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_DN": "Genes down-regulated in D-341 MED (OBR) cells (medulloblastoma) resistant to both carmustine and O6-BG [PubChem=2578;4578].", "AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP": "Genes up-regulated in RWPE-1 cells (prostate cancer) upon expression of constitutively active form of STAT3 [GeneID=6774].", "BAFNA_MUC4_TARGETS_UP": "Genes up-regulated in NIH3T3 cells (fibroblast) engineered to stably express MUC4 [GeneID=4585].", "BAELDE_DIABETIC_NEPHROPATHY_UP": "Genes up-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus).", "BAE_BRCA1_TARGETS_UP": "Genes concordantly up-regulated in DU-145 and MCF-7 cells (lprostate, breast cancer) upon expression of BRCA1.", "BAE_BRCA1_TARGETS_DN": "Genes concordantly down-regulated in DU-145 and MCF-7 cells (lprostate, breast cancer) upon expression of BRCA1.", "BAKER_HEMATOPOESIS_STAT1_TARGETS": "STAT1 [GeneID=6772] targets in hematopoetic signaling.", "BAKER_HEMATOPOESIS_STAT5_TARGETS": "STAT5 [GeneID=6777] targets in hematopoietic signaling.", "BAKER_HEMATOPOIESIS_STAT3_TARGETS": "STAT3 [GeneID=6774] targets in hematopoietic signaling.", "BAELDE_DIABETIC_NEPHROPATHY_DN": "Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus).", "BAKKER_FOXO3_TARGETS_UP": "Genes up-regulated in I/11 erythroblast cells upon expression of an activated form of FOXO3 [GeneID=2309].", "BAKKER_FOXO3_TARGETS_DN": "Genes down-regulated in I/11 erythroblast cells upon expression of an activated form of FOXO3 [GeneID=2309].", "BALLIF_DEVELOPMENTAL_DISABILITY_P16_P12_DELETION": "Candidate genes in the pericentromeric microdeletion in 16p11.2-p12.2 associated with developmental disabilities.", "BALDWIN_PRKCI_TARGETS_UP": "Genes up-regulated in U87MG cells (glioblastoma multiforme) after knockdown of PRKCI [GeneID=5584] by RNAi.", "BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_UP": "Genes up-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 48 h.", "BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_24HR_DN": "Genes down-regulated in A172 cells (glioma, does not express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 24 h.", "BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_24HR_UP": "Genes up-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 24 h.", "BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_24HR_UP": "Genes up-regulated in A172 cells (glioma, does not express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 24 h.", "BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_24HR_DN": "Genes down-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 24 h.", "BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN": "Genes down-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 48 h.", "BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_UP": "Genes up-regulated in A172 cells (glioma, does not express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 48 h.", "BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_DN": "Genes down-regulated in A172 cells (glioma, does not express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 48 h.", "BANG_VERTEPORFIN_ENDOMETRIAL_CANCER_CELLS_DN": "Tha authors analyzed RNA sequencing data to investigate the comprehensive transcriptomic landscape of Verteporfin treated Type 1 endometrial cancer cell lines, including HEC-1-A and HEC-1-B.", "BANG_VERTEPORFIN_ENDOMETRIAL_CANCER_CELLS_UP": "Tha authors analyzed RNA sequencing data to investigate the comprehensive transcriptomic landscape of Verteporfin treated Type 1 endometrial cancer cell lines, including HEC-1-A and HEC-1-B.", "BARIS_THYROID_CANCER_DN": "Genes down-regulated in oncocytic follicular carcinoma (FTC) vs mitochondrial-rich papillary carcinoma (PTC) types of thyroid cancer.", "BARIS_THYROID_CANCER_UP": "Genes up-regulated in oncocytic follicular carcinoma (FTC) vs mitochondrial-rich papillary carcinoma (PTC) types of thyroid cancer.", "BARRIER_CANCER_RELAPSE_TUMOR_SAMPLE_DN": "Down-regulated genes in tumor samples from colon cancer patients who developed recurrence of the disease.", "BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_DN": "Down-regulated genes in non-neoplastic mucosa samples from colon cancer patients who developed recurrence of the disease.", "BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_UP": "Up-regulated genes in non-neoplastic mucosa samples from colon cancer patients who developed recurrence of the disease.", "BARRIER_CANCER_RELAPSE_TUMOR_SAMPLE_UP": "Up-regulated genes in tumor samples from colon cancer patients who developed recurrence of the disease.", "BARRIER_COLON_CANCER_RECURRENCE_DN": "Down-regulated genes from the 70-gene prognosis predictor for stage 2 colon cancer, based on non-neoplastic mucosa gene expression profiles.", "BARRIER_COLON_CANCER_RECURRENCE_UP": "Up-regulated genes from the 70-gene prognosis predictor for stage 2 colon cancer, based on non-neoplastic mucosa gene expression profiles.", "BASSO_CD40_SIGNALING_DN": "Gene down-regulated by CD40 [GeneID=958] signaling in Ramos cells (EBV negative Burkitt lymphoma).", "BASAKI_YBX1_TARGETS_UP": "Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi.", "BAUS_TFF2_TARGETS_DN": "Genes down-regulated in pyloric atrium with knockout of TFF2 [GeneID=7032].", "BASSO_HAIRY_CELL_LEUKEMIA_DN": "Genes down-regulated in hairy cell leukemia (HCL) compared with normal and other neoplastic B cell populations.", "BASSO_HAIRY_CELL_LEUKEMIA_UP": "Genes up-regulated in hairy cell leukemia (HCL) compared with normal and other neoplastic B cell populations.", "BASAKI_YBX1_TARGETS_DN": "Genes down-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi.", "BASSO_CD40_SIGNALING_UP": "Gene up-regulated by CD40 [GeneID=958] signaling in Ramos cells (EBV negative Burkitt lymphoma).", "BASSO_B_LYMPHOCYTE_NETWORK": "Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes.", "BAUS_TFF2_TARGETS_UP": "Genes up-regulated in pyloric atrium with knockout of TFF2 [GeneID=7032].", "BECKER_TAMOXIFEN_RESISTANCE_DN": "Genes down-regulated in a breast cancer cell line resistant to tamoxifen [PubChem=5376] compared to the parental line sensitive to the drug.", "BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_AND_PAX3": "Genes up-regulated in SaOS-2 cells (osteosarcoma) upon expression of PAX3-FOXO1 [GeneID=5077;2308] but down-regulated by PAX3 expression off adenoviral vectors.", "BECKER_TAMOXIFEN_RESISTANCE_UP": "Genes up-regulated in a breast cancer cell line resistant to tamoxifen [PubChem=5376] compared to the parental line sensitive to the drug.", "BEIER_GLIOMA_STEM_CELL_UP": "Genes up-regulated in cancer stem cells derived from glyoblastoma tumors: CD133+ [GeneID=8842]  vs. CD133- cells.", "BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_UP": "Genes up-regulated in SaOS-2 cells (osteosarcoma) upon expression of PAX3-FOXO1 [GeneID=5077;2308] fusion protein off an adenoviral vector.", "BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN": "Genes down-regulated in SaOS-2 cells (osteosarcoma) upon expression of PAX3-FOXO1 [GeneID=5077;2308] fusion protein off an adenoviral vector.", "BEIER_GLIOMA_STEM_CELL_DN": "Genes down-regulated in cancer stem cells derived from glyoblastoma tumors: CD133+ [GeneID=8842]  vs. CD133- cells.", "BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS": "Genes significantly up-regulated in the blood mononuclear cells from patients with systemic lupus erythematosus compared to those from healthy persons.", "BENITEZ_GBM_PROTEASOME_INHIBITION_RESPONSE": "102 proteins were identified that were specifically and significantly accumulated after proteasome inhibition with carfilzomibin the PTEN-KO GBM spheres compared with placebo-treated and were not statistically present in the PTEN-WT drug vs placebo group at the proteomic level, this proteomic signature was then coorelated with the RNA-level transcriptomic response to carfilzomib using GSEA. The leading edge of the enrichment result was selected as the response signature.", "BENPORATH_ES_2": "Set 'Set 'ES exp2': genes overexpressed in human embryonic stem cells according to a meta-analysis of 8 profiling studies.", "BENPORATH_CYCLING_GENES": "Genes showing cell-cycle stage-specific expression [PMID=12058064].", "BENPORATH_ES_1": "Set 'ES exp1': genes overexpressed in human embryonic stem cells according to 5 or more out of 20 profiling studies.", "BENPORATH_EED_TARGETS": "Set 'Eed targets': genes identified by ChIP on chip as targets of the Polycomb protein EED [GeneID=8726] in human embryonic stem cells.", "BENPORATH_ES_CORE_NINE": "Set 'Core 9': 'embryonic stem cell' transcription regulators that are preferentially and coordinately overexpressed in the high-grade, ER-negative breast cancer tumors.", "BENPORATH_ES_CORE_NINE_CORRELATED": "Breast cancer compendium: 100 transcription regulators showing most correlated expression with the 9 'embryonic stem cell' transcription factors that are preferentially and coordinately overexpressed in the high-grade, ER-negative breast cancer tumors.", "BENPORATH_MYC_TARGETS_WITH_EBOX": "Set 'Myc targets1': targets of c-Myc [GeneID=4609] identified by ChIP on chip in cultured cell lines, focusing on E-box-containing genes; high affinity bound subset", "BENPORATH_MYC_MAX_TARGETS": "Set 'Myc targets2': targets of c-Myc [GeneID=4609] and Max [GeneID=4149] identified by ChIP on chip in a Burkitt's lymphoma cell line; overlap set.", "BENPORATH_NOS_TARGETS": "Set 'NOS targets': genes upregulated and identified by ChIP on chip as targets of the transcription factors NANOG , OCT4, and Sox2 [GeneID=79923;5460;6657] (NOS) in human embryonic stem cells.", "BENPORATH_NANOG_TARGETS": "Set 'Nanog targets': genes upregulated and identified by ChIP on chip as Nanog [GeneID=79923] transcription factor targets in human embryonic stem cells.", "BENPORATH_ES_WITH_H3K27ME3": "Set 'H3K27 bound': genes posessing the trimethylated H3K27 (H3K27me3) mark in their promoters in human embryonic stem cells, as identified by ChIP on chip.", "BENPORATH_PROLIFERATION": "Set 'Proliferation Cluster': genes defined in human breast tumor expression data.", "BENPORATH_OCT4_TARGETS": "Set 'Oct4 targets': genes upregulated and identified by ChIP on chip as OCT4 [GeneID=5460] transcription factor targets in human embryonic stem cells.", "BENPORATH_PRC2_TARGETS": "Set 'PRC2 targets': Polycomb Repression Complex 2 (PRC) targets; identified by ChIP on chip on human embryonic stem cells as genes that: posess the trimethylated H3K27 mark in their promoters and are bound by SUZ12 [GeneID=23512] and EED [GeneID=8726] Polycomb proteins.", "BENPORATH_SOX2_TARGETS": "Set 'Sox2 targets': genes upregulated and identified by ChIP on chip as SOX2 [GeneID=6657] transcription factor targets in human embryonic stem cells.", "BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN": "Genes down-regulated in NIH3T3 cells (fibroblasts) after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins; the changes did not depend on expression of constitutively active (Q63L) form of RHOA [GeneID=387].", "BENPORATH_SUZ12_TARGETS": "Set 'Suz12 targets': genes identified by ChIP on chip as targets of the Polycomb protein SUZ12 [GeneID=23512] in human embryonic stem cells.", "BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_UP": "Genes up-regulated in NIH3T3 cells (fibroblasts) after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins; the changes did not depend on expression of constitutively active (Q63L) form of RHOA [GeneID=387].", "BERENJENO_TRANSFORMED_BY_RHOA_REVERSIBLY_UP": "Genes up-regulated in NIH3T3 cells (fibroblasts) transformed by  expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector; their expression reverted completely after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins.", "BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_UP": "Genes up-regulated in NIH3T3 cells (fibroblasts) transfrormed by expression of constitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector; their expression did NOT reverted completely after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins.", "BERENJENO_TRANSFORMED_BY_RHOA_REVERSIBLY_DN": "Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by  expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector; their expression reverted completely after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins.", "BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN": "Genes down-regulated in NIH3T3 cells (fibroblasts) transfrormed by expression of constitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector; their expression did NOT reverted completely after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins.", "BERENJENO_TRANSFORMED_BY_RHOA_DN": "Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by  expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector.", "BERGER_MBD2_TARGETS": "Genes strongly up-regulated in colon tissue upon MBD2 [GeneID=8932] knockout.", "BERNARD_PPAPDC1B_TARGETS_DN": "Genes down-regulated in ZR-75-1 cells (breast cancer, amplified 8p11-12 region) upon knockdown of PPAPDC1B [GeneID=84513] by RNAi.", "BERNARD_PPAPDC1B_TARGETS_UP": "Genes up-regulated in ZR-75-1 cells (breast cancer, amplified 8p11-12 region) upon knockdown of PPAPDC1B [GeneID=84513] by RNAi.", "BERENJENO_TRANSFORMED_BY_RHOA_UP": "Genes up-regulated in NIH3T3 cells (fibroblasts) transformed by  expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector.", "BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN": "Genes down-regulated in the invasive ductal carcinoma (IDC) compared to the invasive lobular carcinoma (ILC), the two major pathological types of breast cancer.", "BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_UP": "Genes up-regulated in the invasive ductal carcinoma (IDC) compared to the invasive lobular carcinoma (ILC), the two major pathological types of breast cancer.", "BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_DN": "Down-regulated genes in MDA-MB-435 cells (breast cancer) undergoing G2/M arrest after treatment with 2-methoxyestradiol (2ME2) [PubChem=1573].", "BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN": "Genes down-regulated in medullary breast cancer (MBC) relative to ductal breast cancer (DBD).", "BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP": "Up-regulated genes in MDA-MB-435 cells (breast cancer) undergoing G2/M arrest after treatment with 2-methoxyestradiol (2ME2)[PubChem=1573].", "BHATTACHARYA_EMBRYONIC_STEM_CELL": "The 'stemnes' signature: genes up-regulated and common to 6 human embryonic stem cell lines tested.", "BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP": "Genes up-regulated in medullary breast cancer (MBC) relative to ductal breast cancer (DBD).", "BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN": "Genes bound by ESR1 [GeneID=2099] and down-regulated by estradiol [PubChem=5757] in MCF-7 cells (breast cancer).", "BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP": "Genes bound by ESR1 [GeneID=2099] and up-regulated by estradiol [PubChem=5757] in MCF-7 cells (breast cancer).", "BHAT_ESR1_TARGETS_VIA_AKT1_DN": "Genes bound by ESR1 [GeneID=2099] and down-regulated by estradiol [PubChem=5757] in MCF-7 cells (breast cancer) expressing constitutevly active form of AKT1 [GeneID=207].", "BIERIE_INFLAMMATORY_RESPONSE_TGFB1": "Inflammatory genes down-regulated in mammary carcinoma cells after stimulation with TGFB1 [GeneID=7040] for 1 hr.", "BHAT_ESR1_TARGETS_VIA_AKT1_UP": "Genes bound by ESR1 [GeneID=2099] and up-regulated by estradiol [PubChem=5757] in MCF-7 cells (breast cancer) expressing constitutevly active form of AKT1 [GeneID=207].", "BILANGES_RAPAMYCIN_SENSITIVE_GENES": "Genes translationally regulated in MEF cells (embryonic fibroblasts) by rapamycin (sirolimus) [PubChem=6610346] but not in response to serum deprivation.", "BIDUS_METASTASIS_UP": "Genes up-regulated in endometroid endometrial tumors from patients with lymph node metastases compared to those without the metastases.", "BIDUS_METASTASIS_DN": "Genes down-regulated in endometroid endometrial tumors from patients with lymph node metastases compared to those without the metastases.", "BILANGES_RAPAMYCIN_SENSITIVE_VIA_TSC1_AND_TSC2": "Genes translationally repressed by rapamycin (sirolimus) [PubChem=6610346] in MEF cells (embryonic fibroblast) lacking either TSC1 or TSC2 [GeneID=7248] [GeneID=7249] but not in the wild type cells.", "BILANGES_SERUM_AND_RAPAMYCIN_SENSITIVE_GENES": "Genes translationally regulated in MEF cells (embryonic fibroblasts) in response to serum starvation and by rapamycin (sirolimus) [PubChem=6610346].", "BILANGES_SERUM_RESPONSE_TRANSLATION": "Genes translationally repressed upon serum deprivation in MEF cells (embryonic fibroblast).", "BILANGES_SERUM_SENSITIVE_GENES": "Genes translationally regulated in MEF cells (embryonic fibroblasts) in response to serum starvation but not by rapamycin (sirolimus) [PubChem=6610346].", "BILANGES_SERUM_SENSITIVE_VIA_TSC1": "Genes translationally up-regulated by serum in MEF cells (embryonic fibroblast) lacking TSC1 [GeneID=7248].", "BILANGES_SERUM_SENSITIVE_VIA_TSC2": "Genes translationally up-regulated by serum in MEF cells (embryonic fibroblast) lacking TSC2 [GeneID=7249].", "BILBAN_B_CLL_LPL_UP": "Genes up-regulated in B-CLL (B-cell chronic leukemia) samples expressing high levels of LPL [GeneID=4023] compared with those expressing low levels of the gene.", "BILBAN_B_CLL_LPL_DN": "Genes down-regulated in B-CLL (B-cell chronic leukemia) samples expressing high levels of LPL [GeneID=4023] compared with those expressing low levels of the gene.", "BILD_CTNNB1_ONCOGENIC_SIGNATURE": "Genes selected in supervised analyses to discriminate cells expressing activated beta-catenin (CTNNB1) [GeneID=1499] oncogene from control cells expressing GFP.", "BILD_MYC_ONCOGENIC_SIGNATURE": "Genes selected in supervised analyses to discriminate cells expressing c-Myc [GeneID=4609] from control cells expressing GFP.", "BILD_SRC_ONCOGENIC_SIGNATURE": "Genes selected in supervised analyses to discriminate cells expressing c-Src (CSK) [GeneID=1445] from control cells expressing GFP.", "BILD_E2F3_ONCOGENIC_SIGNATURE": "Genes selected in supervised analyses to discriminate cells expressing E2F3 [GeneID=1871] from control cells expressing GFP.", "BILD_HRAS_ONCOGENIC_SIGNATURE": "Genes selected in supervised analyses to discriminate cells expressing activated HRAS [GeneID=3265] oncogene from control cells expressing GFP.", "BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN": "Genes down-regulated in patients at the incipient stage of Alzheimer's disease.", "BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP": "Genes up-regulated in patients at the incipient stage of Alzheimer's disease.", "BLALOCK_ALZHEIMERS_DISEASE_DN": "Genes down-regulated in brain from patients with Alzheimer's disease.", "BLANCO_MELO_BETA_INTERFERON_TREATED_BRONCHIAL_EPITHELIAL_CELLS_DN": "Genes down-regulated on treatment of normal human bronchial epithelial cells with beta interferon (hIFNB treatment 100u/ml, 4-12hrs).", "BLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_DEL_NS1_INFECTION_DN": "Genes down-regulated on infection of normal human bronchial epithelial cells by mutant Influenza A lacking its antiviral antagonist (IAV_NS1) (MOI: 3, 12hpi)", "BLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_INFECTION_DN": "Genes down-regulated oninfection of normal human bronchial epithelial cells by Influenza A (MOI: 3, 12hpi)", "BLANCO_MELO_BETA_INTERFERON_TREATED_BRONCHIAL_EPITHELIAL_CELLS_UP": "Genes up-regulated on treatment of normal human bronchial epithelial cells with beta interferon (hIFNB treatment 100u/ml, 4-12hrs).", "BLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_DEL_NS1_INFECTION_UP": "Genes up-regulated on infection of normal human bronchial epithelial cells by mutant Influenza A lacking its antiviral antagonist (IAV_NS1) (MOI: 3, 12hpi)", "BLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_INFECTION_UP": "Genes up-regulated oninfection of normal human bronchial epithelial cells by Influenza A (MOI: 3, 12hpi)", "BLANCO_MELO_COVID19_BRONCHIAL_EPITHELIAL_CELLS_SARS_COV_2_INFECTION_DN": "\u00a0", "BLALOCK_ALZHEIMERS_DISEASE_UP": "Genes up-regulated in brain from patients with Alzheimer's disease.", "BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_DN": "Genes down-regulated in SARS-CoV-2 infection (ACE2 expressing A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_BRONCHIAL_EPITHELIAL_CELLS_SARS_COV_2_INFECTION_UP": "Genes up-regulated on infection of normal human bronchial epithelial cells by SARS-CoV-2 (MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_RUXOLITINIB_DN": "Genes down-regulated in SARS-CoV-2 infection with Ruxolitinib (ACE2 expressing A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_CELLS_DN": "Genes down-regulated in SARS-CoV-2 infection (A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_CALU3_CELLS_DN": "Genes down-regulated in SARS-CoV-2 infection (Calu-3 cells, MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_RUXOLITINIB_UP": "Genes up-regulated in SARS-CoV-2 infection with Ruxolitinib (ACE2 expressing A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_CELLS_UP": "Genes up-regulated in SARS-CoV-2 infection (A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_UP": "Genes up-regulated in SARS-CoV-2 infection (ACE2 expressing A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_LOW_MOI_INFECTION_A594_ACE2_EXPRESSING_CELLS_DN": "Genes down-regulated in SARS-CoV-2 low MOI infection (ACE2 expressing A549 cells, MOI: 0.2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_LOW_MOI_INFECTION_A594_ACE2_EXPRESSING_CELLS_UP": "Genes up-regulated in SARS-CoV-2 low MOI infection (ACE2 expressing A549 cells, MOI: 0.2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_CALU3_CELLS_UP": "Genes up-regulated in SARS-CoV-2 infection (Calu-3 cells, MOI: 2, 24hpi)", "BLANCO_MELO_COVID19_SARS_COV_2_POS_PATIENT_LUNG_TISSUE_DN": "Genes strongly down-regulated (og2(FC)<-3.58, padj<0.05) in post mortem lung tissue from COVID-19 patients vs uninfected biopsy.", "BLANCO_MELO_COVID19_SARS_COV_2_POS_PATIENT_LUNG_TISSUE_UP": "Genes strongly up-regulated (log2(FC)>3.58, padj<0.05) in post mortem lung tissue from COVID-19 patients vs uninfected biopsy.", "BLANCO_MELO_HUMAN_PARAINFLUENZA_VIRUS_3_INFECTION_A594_CELLS_DN": "Genes down-regulated in HPIV3 (A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_INFLUENZA_A_INFECTION_A594_CELLS_UP": "Genes up-regulated in IAV (A549 cells, MOI: 5, 9hpi)", "BLANCO_MELO_MERS_COV_INFECTION_MCR5_CELLS_DN": "Genes down-regulated in MERS-CoV infection (MRC5 cells, MOI: 3, 24hpi)", "BLANCO_MELO_HUMAN_PARAINFLUENZA_VIRUS_3_INFECTION_A594_CELLS_UP": "Genes up-regulated in HPIV3 (A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_INFLUENZA_A_INFECTION_A594_CELLS_DN": "Genes down-regulated in IAV (A549 cells, MOI: 5, 9hpi)", "BLANCO_MELO_SARS_COV_1_INFECTION_MCR5_CELLS_DN": "Genes down-regulated in SARS-CoV-1 infection (MRC5 cells, MOI: 3, 24hpi).", "BLANCO_MELO_SARS_COV_1_INFECTION_MCR5_CELLS_UP": "Genes up-regulated in SARS-CoV-1 infection (MRC5 cells, MOI: 3, 24hpi).", "BLANCO_MELO_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_A594_CELLS_DN": "Genes down-regulated in RSV (A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_A594_CELLS_UP": "Genes up-regulated in RSV (A549 cells, MOI: 2, 24hpi)", "BLANCO_MELO_MERS_COV_INFECTION_MCR5_CELLS_UP": "Genes up-regulated in MERS-CoV infection (MRC5 cells, MOI: 3, 24hpi)", "BLUM_RESPONSE_TO_SALIRASIB_DN": "Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265].", "BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_DN": "Genes down-regulated in ALL (acute lymphoblastic leukemia) patients who developed t-ML (treatment related myeloid leukemia).", "BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_UP": "Genes up-regulated in ALL (acute lymphoblastic leukemia) patients who developed t-ML (treatment related myeloid leukemia).", "BLUM_RESPONSE_TO_SALIRASIB_UP": "Selected genes up-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265].", "BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_UP": "Genes up-regulated in B lymphocytes from patients with primary immunodefiency syndrom.", "BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_DN": "Genes down-regulated in B lymphocytes from patients with primary immunodefiency syndrom.", "BONOME_OVARIAN_CANCER_POOR_SURVIVAL_DN": "Top highly correlated genes negatively associated with poor survival of patients with suboptimally debulked ovarian tumors.", "BONCI_TARGETS_OF_MIR15A_AND_MIR16_1": "Potential targets of MIR15A and MIR16-1 [GeneID=406948;406950] microRNAs in prostate cancer.", "BOCHKIS_FOXA2_TARGETS": "Direct targets of FOXA2 [GeneID=3170] in liver, according to a ChIP-chip analysis.", "BONOME_OVARIAN_CANCER_POOR_SURVIVAL_UP": "Top highly correlated genes positively associated with poor survival of patients with suboptimally debulked ovarian tumors.", "BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING": "Genes whose expression in optimally debulked ovarian tumors is associated with survival prognosis.", "BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN": "Genes down-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells.", "BORCZUK_MALIGNANT_MESOTHELIOMA_DN": "Genes down-regulated in biphasic (mixed) vs epithelial subtypes of malignant peritoneal mesothelioma.", "BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING": "Genes whose expression in suboptimally debulked ovarian tumors is associated with survival prognosis.", "BOQUEST_STEM_CELL_DN": "Genes down-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts.", "BORLAK_LIVER_CANCER_EGF_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) developed by transgenic mice overexpressing a secretable form of EGF [GeneID=1950] in liver.", "BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE": "Genes representing a co-expression network in atopic CD4 [GeneID=920] T lymphocyte responses.", "BOQUEST_STEM_CELL_UP": "Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts.", "BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP": "Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells.", "BORCZUK_MALIGNANT_MESOTHELIOMA_UP": "Genes up-regulated in biphasic (mixed) vs epithelial subtypes of malignant peritoneal mesothelioma.", "BOSCO_EPITHELIAL_DIFFERENTIATION_MODULE": "Genes representing epithelial differentiation module in sputum during asthma exacerbations.", "BOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE": "Genes representing interferon-induced antiviral module in sputum during asthma exacerbations.", "BOSCO_TH1_CYTOTOXIC_MODULE": "Genes representing Th1 / cytotoxic module in sputum during asthma exacerbations.", "BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX": "Genes up-regulated by growing HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [GeneID=1489078]) in extracellular matrix (ECM).", "BOWIE_RESPONSE_TO_TAMOXIFEN": "Genes up-regulated  by tamoxifen [PubChem=5376] in HMEC-E6 cells (mammary epithelial cells damaged by expression of HPV-16 E6 [GeneID=1489078]).", "BOUDOUKHA_BOUND_BY_IGF2BP2": "Transcripts bound to IGF2BP2 [GeneID=10644] complexes and differentially regulated in myoblasts with IGF2BP2 [GeneID=10644] knockdown by RNAi.", "BOYAULT_LIVER_CANCER_SUBCLASS_G123_DN": "Down-regulated genes in hepatocellular  carcinoma (HCC) subclass G123, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G12_UP": "Up-regulated genes in hepatocellular carcinoma (HCC) subclass G12, defined by unsupervised clustering", "BOYAULT_LIVER_CANCER_SUBCLASS_G12_DN": "Down-regulated genes in hepatocellular carcinoma (HCC) subclass G12, defined by unsupervised clustering", "BOYAULT_LIVER_CANCER_SUBCLASS_G123_UP": "Up-regulated genes in hepatocellular  carcinoma (HCC) subclass G123, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G1_DN": "Down-regulated genes in hepatocellular carcinoma (HCC) subclass G1, defined by unsupervised clustering", "BOYAULT_LIVER_CANCER_SUBCLASS_G1_UP": "Up-regulated genes in hepatocellular carcinoma (HCC) subclass G1, defined by unsupervised clustering", "BOYAULT_LIVER_CANCER_SUBCLASS_G2": "Genes in hepatocellular carcinoma (HCC) subclass G2, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G3_DN": "Down-regulated genes in hepatocellular carcinoma (HCC) subclass G3, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G23_UP": "Up-regulated genes in hepatocellular carcinoma (HCC) subclass G23, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G23_DN": "Down-regulated genes in hepatocellular carcinoma (HCC) subclass G23, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G56_UP": "Up-regulated genes in hepatocellular carcinoma (HCC) subclass G56, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP": "Up-regulated genes in hepatocellular carcinoma (HCC) subclass G3, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G6_DN": "Down-regulated genes in hepatocellular carcinoma (HCC) subclass G6, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G5_DN": "Down-regulated genes in hepatocellular carcinoma (HCC) subclass G5, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G56_DN": "Down-regulated genes in hepatocellular carcinoma (HCC) subclass G56, defined by unsupervised clustering.", "BOYAULT_LIVER_CANCER_SUBCLASS_G6_UP": "Up-regulated genes in hepatocellular carcinoma (HCC) subclass G6, defined by unsupervised clustering.", "BOYERINAS_ONCOFETAL_TARGETS_OF_LET7A1": "Embryonic genes targeted by LET7A1 [GeneID=406881] and which are up-regulated in many human cancers.", "BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP": "Genes from cluster 1: up-regulated in group C of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_DN": "Genes from cluster 2: down-regulated in group C of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_C_DN": "Genes down-regulated in group C of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_C_UP": "Genes up-regulated in group C of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_UP": "Genes from cluster 3: up-regulated in group D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_DN": "Genes from cluster 4: down-regulated in group D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_C_D_DN": "Genes down-regulated both in group C and D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_C_D_UP": "Genes up-regulated both in group C and D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_D_UP": "Genes up-regulated in group D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_D_DN": "Genes down-regulated in group D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells.", "BOYLAN_MULTIPLE_MYELOMA_PCA1_DN": "Top down-regulated genes from principal component 1 (PCA1) which captures variation between normal plasma cells and tumors arising from aberrant expression of BCL2L1 and MYC [GeneID=598;4609].", "BOYLAN_MULTIPLE_MYELOMA_PCA3_DN": "Top down-regulated genes from principal component 3 (PCA3) which captures variation among different plasma cell tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609].", "BOYLAN_MULTIPLE_MYELOMA_PCA1_UP": "Top up-regulated genes from principal component 1 (PCA1) which captures variation between normal plasma cells and tumors arising from aberrant expression of BCL2L1 and MYC [GeneID=598;4609].", "BOYLAN_MULTIPLE_MYELOMA_PCA3_UP": "Top up-regulated genes from principal component 3 (PCA3) which captures variation among different plasma cell tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609].", "BRACHAT_RESPONSE_TO_METHOTREXATE_DN": "Genes down-regulated in  FL5.12 cells (pro-B lymphocyte) in response to methotrexate [PubChem=4112].", "BRACHAT_RESPONSE_TO_CISPLATIN": "Genes up-regulated in FL5.12 cells (pro-B lymphocyte) in response to cisplatin [PubChem=2767].", "BRACHAT_RESPONSE_TO_CAMPTOTHECIN_UP": "Genes specifically up-regulated in FL5.12 cells (pro-B lymphocyte) by  camptothecin [PubChem=2538].", "BRACHAT_RESPONSE_TO_CAMPTOTHECIN_DN": "Genes specifically down-regulated in FL5.12 cells (pro-B lymphocyte) by  camptothecin [PubChem=2538].", "BRAUNE_GEIST_20_GENE_NOTCH_SIG_BREAST_CANCER": "Notch transcriptomic signature as a tool to measure the level of Notch signaling in breast cancer", "BRACHAT_RESPONSE_TO_METHOTREXATE_UP": "Genes up-regulated in  FL5.12 cells (pro-B lymphocyte) in response to methotrexate [PubChem=4112].", "BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_DN": "Genes down-regulated in pre B lymphocyte after induction of physiological DNA double-strand breaks (DSB) by RAG2 [GeneID=5897]; the changes are independent of ATM [GeneID=472] signaling.", "BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP": "Genes up-regulated in pre B lymphocyte after induction of physiological DNA double-strand breaks (DSB) by RAG2 [GeneID=5897]; the changes are independent of ATM [GeneID=472] signaling.", "BREDEMEYER_RAG_SIGNALING_VIA_ATM_NOT_VIA_NFKB_DN": "Genes down-regulated in pre B lymphocyte after induction of physiological DNA double-strand breaks (DSB) by RAG2 [GeneID=5897]; the changes depend on ATM [GeneID=472] but not NFKB signaling.", "BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER": "Growth factor signaling components up-regulated  in hepatocellular carcinoma (HCC).", "BREDEMEYER_RAG_SIGNALING_VIA_ATM_NOT_VIA_NFKB_UP": "Genes up-regulated in pre B lymphocyte after induction of physiological DNA double-strand breaks (DSB) by RAG2 [GeneID=5897]; the changes depend on ATM [GeneID=472] but not NFKB signaling.", "BRIDEAU_IMPRINTED_GENES": "List of genomically imprinted genes.", "BROCKE_APOPTOSIS_REVERSED_BY_IL6": "Genes changed in INA-6 cells (multiple myeloma, MM) by re-addition of IL6 [GeneID=3569] after its initial withdrawal for 12h.", "BROWNE_HCMV_INFECTION_10HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 10 h time point that were not down-regulated at the previous time point, 8 h.", "BROWNE_HCMV_INFECTION_12HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 12 h time point that were not down-regulated at the previous time point, 10 h.", "BROWNE_HCMV_INFECTION_12HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 12 h time point that were not up-regulated at the previous time point, 10 h.", "BROWNE_HCMV_INFECTION_10HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 10 h time point that were not up-regulated at the previous time point, 8 h.", "BROWNE_HCMV_INFECTION_16HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 16 h time point that were not down-regulated at the previous time point, 14 h.", "BROWNE_HCMV_INFECTION_14HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 14 h time point that were not up-regulated at the previous time point, 12 h.", "BROWNE_HCMV_INFECTION_14HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 14 h time point that were not down-regulated at the previous time point, 12 h.", "BROWNE_HCMV_INFECTION_18HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 18 h time point that were not down-regulated at the previous time point, 16 h.", "BROWNE_HCMV_INFECTION_16HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 16 h time point that were not up-regulated at the previous time point, 14 h.", "BROWNE_HCMV_INFECTION_1HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 1 h time point that were not up-regulated at the previous time point, 30 min.", "BROWNE_HCMV_INFECTION_20HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 20 h time point that were not down-regulated at the previous time point, 18 h.", "BROWNE_HCMV_INFECTION_1HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 1 h time point that were not down-regulated at the previous time point, 30 min.", "BROWNE_HCMV_INFECTION_18HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 18 h time point that were not up-regulated at the previous time point, 16 h.", "BROWNE_HCMV_INFECTION_20HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 20 h time point that were not up-regulated at the previous time point, 18 h.", "BROWNE_HCMV_INFECTION_24HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 24 h time point that were not down-regulated at the previous time point, 20 h.", "BROWNE_HCMV_INFECTION_2HR_DN": "Genes down-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 2 h time point that were not down-regulated at the previous time point, 1 h.", "BROWNE_HCMV_INFECTION_24HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 24 h time point that were not up-regulated at the previous time point, 20 h.", "BROWNE_HCMV_INFECTION_2HR_UP": "Genes up-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 2 h time point that were not up-regulated at the previous time point, 1 h.", "BROWNE_HCMV_INFECTION_30MIN_UP": "Genes up-regulated in primary fibroblast cell culture at 30 min time point after infection with HCMV (AD169 strain).", "BROWNE_HCMV_INFECTION_30MIN_DN": "Genes down-regulated in primary fibroblast cell culture at 30 min time point after infection with HCMV (AD169 strain).", "BROWNE_HCMV_INFECTION_4HR_DN": "Genes down-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 4 h time point that were not down-regulated at the previous time point, 2 h.", "BROWNE_HCMV_INFECTION_48HR_UP": "Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 48 h time point that were not up-regulated at the previous time point, 24 h.", "BROWNE_HCMV_INFECTION_4HR_UP": "Genes up-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 4 h time point that were not up-regulated at the previous time point, 2 h.", "BROWNE_HCMV_INFECTION_48HR_DN": "Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 48 h time point that were not down-regulated at the previous time point, 24 h.", "BROWNE_HCMV_INFECTION_6HR_UP": "Genes up-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 6 h time point that were not up-regulated at the previous time point, 4 h.", "BROWNE_HCMV_INFECTION_8HR_DN": "Genes down-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 8 h time point that were not down-regulated at the previous time point, 6 h.", "BROWNE_HCMV_INFECTION_6HR_DN": "Genes down-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 6 h time point that were not down-regulated at the previous time point, 4 h.", "BROWNE_HCMV_INFECTION_8HR_UP": "Genes up-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 8 h time point that were not up-regulated at the previous time point, 6 h.", "BROWNE_INTERFERON_RESPONSIVE_GENES": "Genes up-regulated in primary fibroblast culture after treatment with interferon alpha for 6 h.", "BROWN_MYELOID_CELL_DEVELOPMENT_DN": "Genes defining proliferation and self renewal potential of the bipotential myeloid cell line FDB.", "BRUECKNER_TARGETS_OF_MIRLET7A3_DN": "Genes down-regulated in A549 cells (lung cancer) expressing MIRLET7A3 [GeneID=406883] microRNA off a plasmid vector.", "BRUECKNER_TARGETS_OF_MIRLET7A3_UP": "Genes up-regulated in A549 cells (lung cancer) expressing MIRLET7A3 [GeneID=406883] microRNA off a plasmid vector.", "BROWN_MYELOID_CELL_DEVELOPMENT_UP": "Genes defining differentiation potential of the bipotential myeloid cell line FDB.", "BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_C": "Category C genes: p53-independent genes whose expression in the absence of S389 phosphorylation is dissimilar to loss of TP53 [GeneID=7157] in MEF (embryonic fibroblast) cells in response to UV-C irradiation.", "BRUINS_UVC_RESPONSE_MIDDLE": "Middle response genes: differentially expressed in the period between 3 h and 12 h after UV-C irradiation of MEF cells (embryonic fibroblast).", "BRUNEAU_HEART_GREAT_VESSELS_AND_VALVULOGENESIS": "Genes for which mutations result in developmental defects in the great vessels formation and valvulogenesis, a major class of congenital heart disease.", "BRUNEAU_SEPTATION_VENTRICULAR": "Genes for which mutations result in developmental defects in ventricular septation and atrioventricular cushion formation, a major class of congenital heart disease.", "BRUNEAU_SEPTATION_ATRIAL": "Genes for which mutations result in atrial septation defects, a major class of congenital heart disease.", "BRUINS_UVC_RESPONSE_LATE": "Late response genes: differentially expressed only 12 h after UV-C irradiation of MEF cells (embryonic fibroblast).", "BRUINS_UVC_RESPONSE_EARLY_LATE": "Early-late response genes: differentially expressed in the first 3 h and after 12 h following UV-C irradiation of MEF cells (embryonic fibroblast).", "BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B": "Category B genes: p53-dependent genes whose expression in the absence of S389 phosphorylation is dissimilar to loss of TP53 [GeneID=7157] in MEF (embryonic fibroblast) cells in response to UV-C irradiation.", "BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D": "Category D genes: p53-independent genes whose expression in the absence of S389 phosphorylation is similar to loss of TP53 [GeneID=7157] in MEF (embryonic fibroblast) cells in response to UV-C irradiation.", "BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A": "Category A genes: p53-dependent genes whose expression in the absence of S389 phosphorylation is similar to loss of TP53 [GeneID=7157] in MEF (embryonic fibroblast) cells in response to UV-C irradiation.", "BRUNO_HEMATOPOIESIS": "Genes that are rapidly down-regulated as multipotential cells of the FDCP-mix hematopoiesis model undergo differentiation and loose their self-renewal and proliferation properties.", "BUCKANOVICH_T_LYMPHOCYTE_HOMING_ON_TUMOR_DN": "Genes  down-regulated in microdissected endothelial samples from ovarian cancer tumors with tumor-infiltrating lymphocytes (TIL) vs those without TILs.", "BUFFA_HYPOXIA_METAGENE": "Common genes regulated by hypoxia across multiple head and neck and breast cancer clinical cohorts, and prognostic in multiple cancer types", "BUCKANOVICH_T_LYMPHOCYTE_HOMING_ON_TUMOR_UP": "Genes up-regulated in microdissected endothelial samples from ovarian cancer tumors with tumor-infiltrating lymphocytes (TIL) vs those without TILs.", "BURTON_ADIPOGENESIS_1": "Strongly up-regulated at 2 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_12": "Strongly down-regulated at 2 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_10": "Strongly down-regulated at 8-48 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_11": "Strongly down-regulated at 2-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_2": "Strongly up-regulated at 8 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_3": "Strongly up-regulated at 16-24 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_5": "Up-regulated at 48-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_4": "Progressively up-regulated from 8-48 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_7": "Down-regulated at 48-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_9": "Strongly down-regulated at 8-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_8": "Progressively down-regulated 8-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_6": "Strongly up-regulated at 96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.", "BURTON_ADIPOGENESIS_PEAK_AT_0HR": "Cluster 1:  genes progressively down-regulated over 24 h (peak at 0 h timepoint) during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones.", "BURTON_ADIPOGENESIS_PEAK_AT_16HR": "Cluster 4: genes maximally expressed at 16 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones.", "BURTON_ADIPOGENESIS_PEAK_AT_24HR": "Cluster 5: genes progressively up-regulated (peak at 24 h time point) during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones.", "BURTON_ADIPOGENESIS_PEAK_AT_2HR": "Cluster 2: genes maximally expressed at 2 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) in response to adipogenic hormones.", "BURTON_ADIPOGENESIS_PEAK_AT_8HR": "Cluster 3: genes maximally expressed at 8 hr time point  during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones.", "BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN": "Genes down-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress.", "BYSTROEM_CORRELATED_WITH_IL5_DN": "Genes whose expression in bone marrow samples correlated inversely with increased levels of serum IL5 [GeneID=3567].", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_FGF3": "Genes whose expression is coregulated with that of FGF3 [GeneID=2248] in hematopoietic stem cells (HSC).", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_CIS": "Genes associated with the same cis-regulatory QTL (quantitative trait loci) in both brain and hematopoietic stem cells (HSC).", "BYSTROEM_CORRELATED_WITH_IL5_UP": "Genes whose expression in bone marrow samples correlated directly with increased levels of serum IL5 [GeneID=3567].", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_IL3RA": "Genes whose expression is coregulated with that of IL3RA [GeneID=3563] in hematopoietic stem cells (HSC).", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_FLI1": "Genes whose expression is coregulated with that of FLI1 [GeneID=2313] in hematopoietic stem cells (HSC).", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS": "Genes trans-regulated by the same QTL (quantitative trait loci) in brain and hematopoietic stem cells (HSC).", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_CIS": "Transcripts in hematopoietic stem cells (HSC) which are cis-regulated (i.e., modulated by a QTL (quantitative trait locus) in close proximity to the gene).", "BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP": "Genes up-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress.", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_RUNX1": "Genes whose expression is coregulated with that of RUNX1 [GeneID=861] in hematopoietic stem cells (HSC).", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS": "Genes trans-regulated by the hematopoietic stem cell (HSC) proliferation QTL (quantitative trait locus) Scp2.", "CAFFAREL_RESPONSE_TO_THC_24HR_3_DN": "Genes down-regulated in EVSA-T cells (breast cancer) after treatment with 3 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 24 h.", "CAFFAREL_RESPONSE_TO_THC_24HR_3_UP": "Genes up-regulated in EVSA-T cells (breast cancer) after treatment with 3 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 24 h.", "BYSTRYKH_SCP2_QTL": "Genes that physically map to the hematopoietic stem cell (HSC) proliferation QTL (quantitative trait locus) Scp2.", "CADWELL_ATG16L1_TARGETS_DN": "Genes down-regulated in Paneth cell (part of intestiinal epithelium) of mice with hypomorphic (reduced function) form of ATG16L1 [GeneID=55054].", "CAFFAREL_RESPONSE_TO_THC_24HR_5_DN": "Genes down-regulated in EVSA-T cells (breast cancer) treated with 5 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 24 h.", "CADWELL_ATG16L1_TARGETS_UP": "Genes up-regulated in Paneth cell (part of intestiinal epithelium) of mice with hypomorphic (reduced function) form of ATG16L1 [GeneID=55054].", "CAFFAREL_RESPONSE_TO_THC_24HR_5_UP": "Genes up-regulated in EVSA-T cells (breast cancer) treated with 5 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 24 h.", "CAFFAREL_RESPONSE_TO_THC_8HR_3_DN": "Genes down-regulated in EVSA-T cells (breast cancer) treated with 3 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 8 h.", "CAFFAREL_RESPONSE_TO_THC_8HR_3_UP": "Genes up-regulated in EVSA-T cells (breast cancer) treated with 3 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 8 h.", "CAFFAREL_RESPONSE_TO_THC_8HR_5_DN": "Genes down-regulated in EVSA-T cells (breast cancer) treated with 5 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 8 h.", "BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS": "Transcripts in hematopoietic stem cells (HSC) which are trans-regulated (i.e., modulated by a QTL (quantitative trait locus) not in a close proximity to the gene).", "CAFFAREL_RESPONSE_TO_THC_8HR_5_UP": "Genes up-regulated in EVSA-T cells (breast cancer) treated with 5 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 8 h.", "CAFFAREL_RESPONSE_TO_THC_DN": "Genes down-regulated in EVSA-T cells (breast cancer) treated THC (delta-9-tetrahydrocannabinol) [PubChem=6610319].", "CAFFAREL_RESPONSE_TO_THC_UP": "Genes up-regulated in EVSA-T cells (breast cancer) treated THC (delta-9-tetrahydrocannabinol) [PubChem=6610319].", "CAIRO_HEPATOBLASTOMA_CLASSES_DN": "Genes down-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1).", "CAIRO_PML_TARGETS_BOUND_BY_MYC_DN": "Genes down-regulated in MEF cells (embryonic fibroblasts) after knockout of PML [GeneID=5371] and whose promoters were bound by MYC [GeneID=4609].", "CAIRO_HEPATOBLASTOMA_POOR_SURVIVAL": "Genes whose expression classifies hepatoblastoma tumors as belonging to either rC1 or rC2 subtypes and whose expression predicts poor survival.", "CAIRO_PML_TARGETS_BOUND_BY_MYC_UP": "Genes up-regulated in MEF cells (embryonic fibroblasts) after knockout of PML [GeneID=5371] and whose promoters were bound by MYC [GeneID=4609].", "CAIRO_HEPATOBLASTOMA_UP": "Genes up-regulated in hepatoblastoma samples compared to normal liver tissue.", "CALVET_IRINOTECAN_SENSITIVE_VS_RESISTANT_UP": "Genes up-regulated in neuroblastoma xenografts: sensitive vs resistant to the topoisomerase inhibitor irinotecan [GeneID=3750].", "CAIRO_LIVER_DEVELOPMENT_UP": "Genes up-regulated at early fetal liver stage (embryonic days  E11.5 - E12.5) compared to the late fetal liver stage (embryonic days E14.5 - E16.5).", "CAIRO_LIVER_DEVELOPMENT_DN": "Genes down-regulated at early fetal liver stage (embryonic days  E11.5 - E12.5) compared to the late fetal liver stage (embryonic days E14.5 - E16.5).", "CAIRO_HEPATOBLASTOMA_DN": "Genes down-regulated in hepatoblastoma samples compared to normal liver tissue.", "CALVET_IRINOTECAN_SENSITIVE_VS_REVERTED_DN": "Genes down-regulated in neuroblastoma xenografts: resistant vs those that reverted to be sensitive to the topoisomerase inhibitor irinotecan [PubChem=3750].", "CAIRO_HEPATOBLASTOMA_CLASSES_UP": "Genes up-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1).", "CALVET_IRINOTECAN_SENSITIVE_VS_REVERTED_UP": "Genes up-regulated in neuroblastoma xenografts: resistant vs those that reverted to be sensitive to the topoisomerase inhibitor irinotecan [PubChem=3750].", "CARDOSO_RESPONSE_TO_GAMMA_RADIATION_AND_3AB": "Down-regulated synergystically by gamma-irradiation and 3-aminobenzamine [PubChem=1645], an inhibitor of PARP1 [GeneID=142].", "CAMPS_COLON_CANCER_COPY_NUMBER_DN": "Genes from chromosomal copy number losses in a panel of 51 primary colon carcinoma samples.", "CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_HYPERMETHYLATED_AND_DN": "Genes hypermethylated and downexpressed in hepatoblastoma (HB) tumors as compared with non-tumor (NT) adjacent tissue assessed by Infinium MethylationEPIC 850K array and Human Transcriptome Array 2.0 & RNA-sequencing.", "CARD_MIR302A_TARGETS": "Potential targets of MIR302A [GeneID=407028].", "CARRILLOREIXACH_14Q32OVEREXPRESSION_IN_HEPATOBLASTOMA": "Genes enriched in locus DLK1-DIO3 at 14q32 in hepatoblastoma (HB) as compared with non-tumor (NT) adjacent tissue assessed by Human Transcriptome Array (HTA).", "CAMPS_COLON_CANCER_COPY_NUMBER_UP": "Genes from chromosomal copy number gains in a panel of 51 primary colon carcinoma samples.", "CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_HYPOMETHYLATED_AND_UP": "Genes hypomethylated and overexpressed in hepatoblastoma (HB) tumors as compared with non-tumor (NT) adjacent tissue assessed by Infinium MethylationEPIC 850K array and Human Transcriptome Array 2.0 & RNA-sequencing.", "CARRILLOREIXACH_MRS3_VS_LOWER_RISK_HEPATOBLASTOMA_UP": "Genes significantly upregulated in the high-risk Molecular Risk Stratification (MRS-3) hepatoblastoma (HB) as compared with intermediate-risk (MRS-2) and low-risk (MRS-1) molecular HBs, assessed by Human Transcriptome Array (HTA).", "CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_DN": "Genes down-regulated in hepatoblastoma (HB) tumors as compared with non-tumor (NT) adjacent tissue.", "CARRILLOREIXACH_MRS3_VS_LOWER_RISK_HEPATOBLASTOMA_DN": "Genes significantly down-regulated in the high-risk Molecular Risk Stratification (MRS-3) hepatoblastoma (HB) as compared with intermediate-risk (MRS-2) and low-risk (MRS-1) molecular HBs, assessed by Human Transcriptome Array (HTA).", "CASTELLANO_HRAS_AND_NRAS_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblasts) isolated from HRAS and NRAS [GeneID=3265;4893] double knockout mice.", "CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP": "Genes up-regulated in secondary APL (acute promyelocytic leukemia) compared to the de novo tumors.", "CASTELLANO_HRAS_AND_NRAS_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblasts) isolated from HRAS and NRAS [GeneID=3265;4893] double knockout mice.", "CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP": "Genes up-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [GeneID=5371;5914] compared to normal promyeloblasts.", "CASTELLANO_HRAS_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) isolated from HRAS [GeneID=3265] knockout mice.", "CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_UP": "Genes up-regulated in hepatoblastoma (HB) tumors as compared with non-tumor (NT) adjacent tissue.", "CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN": "Genes down-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [GeneID=5371;5914] compared to normal promyeloblasts.", "CASTELLANO_NRAS_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [GeneID=4893] knockout mice.", "CASTELLANO_HRAS_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) isolated from HRAS [GeneID=3265] knockout mice.", "CASTELLANO_NRAS_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [GeneID=4893] knockout mice.", "CAVARD_LIVER_CANCER_MALIGNANT_VS_BENIGN": "Genes identified by subtractive hybridization comparing malignant and benign components of a hepatocellular carcinoma (HCC) in a pre-existing liver adenoma in a morphologically normal liver.", "CEBALLOS_TARGETS_OF_TP53_AND_MYC_UP": "Genes up-regulated in K562 cells (chronic myelogenous leukemia, CML) expressing TP53 and MYC [GeneID=7157;4609].", "CEBALLOS_TARGETS_OF_TP53_AND_MYC_DN": "Genes down-regulated in K562 cells (chronic myelogenous leukemia, CML) expressing TP53 and MYC [GeneID=7157;4609].", "CERIBELLI_GENES_INACTIVE_AND_BOUND_BY_NFY": "Transcriptionally inactive genes which where bound by NF-Y transcription factor.", "CERIBELLI_PROMOTERS_INACTIVE_AND_BOUND_BY_NFY": "Transcriptionally inactive genes whose promoters (regions between -2 kb to +0.5 kb relative to trascription start sites) where bound by NF-Y transcription factor.", "CERVERA_SDHB_TARGETS_1_UP": "Genes turned on in Hep3B cells (hepatocellular carcinoma, HCC) upon knockdown of SDHB [GeneID=6390] by RNAi.", "CERVERA_SDHB_TARGETS_1_DN": "Genes turned off in Hep3B cells (hepatocellular carcinoma, HCC) upon knockdown of SDHB [GeneID=6390] by RNAi.", "CHANDRAN_METASTASIS_TOP50_DN": "Top 50 genes down-regulated in metastatic vs primary prostate cancer  tumors.", "CERVERA_SDHB_TARGETS_2": "Genes present but differentially expressed between Hep3B cells (hepatocellular carcinoma, HCC) with RNAi knockdown of SDHB [GeneID=6390] and control cells.", "CHANDRAN_METASTASIS_DN": "Genes down-regulated in metastatic tumors from the whole panel of patients with prostate cancer.", "CHANDRAN_METASTASIS_TOP50_UP": "Top 50 genes up-regulated in metastatic vs primary prostate cancer  tumors.", "CHANGOLKAR_H2AFY_TARGETS_DN": "Genes down-regulated in liver tissue upon knockout of H2AFY [GeneID=9555].", "CHANDRAN_METASTASIS_UP": "Genes up-regulated in metastatic tumors from the whole panel of patients with prostate cancer.", "CHANGOLKAR_H2AFY_TARGETS_UP": "Genes up-regulated in liver tissue upon knockout of H2AFY [GeneID=9555].", "CHANG_IMMORTALIZED_BY_HPV31_DN": "Genes down-regulated in normal keratinocytes immortalized by infection with the high risk HPV31 (human papilloma virus) strain.", "CHANG_POU5F1_TARGETS_DN": "Genes down-regulated by POU5F1 [GeneID=5460] in bladder cancer cell lines.", "CHANG_IMMORTALIZED_BY_HPV31_UP": "Genes up-regulated in normal keratinocytes immortalized by infection with the high risk HPV31 (human papilloma virus) strain.", "CHANG_POU5F1_TARGETS_UP": "Genes up-regulated by POU5F1 [GeneID=5460] in bladder cancer cell lines.", "CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN": "Genes down-regulated in basal-like breast cancer cell lines as compared to the mesenchymal-like ones.", "CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_UP": "Genes up-regulated in basal-like breast cancer cell lines as compared to the mesenchymal-like ones.", "CHASSOT_SKIN_WOUND": "List of the transcription factors up-regulated 1 hr after wounding HDF cells (dermal fibroblasts).", "CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN": "Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones.", "CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN": "Genes down-regulated by 2-methoxyestradiol (2ME2) [PubChem=1573] in the MM.1S cell line (multiple myeloma) sensitive to dexamethasone [PubChem=5743].", "CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP": "Genes up-regulated in luminal-like breast cancer cell lines compared to the basal-like ones.", "CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_UP": "Genes up-regulated by 2-methoxyestradiol (2ME2) [PubChem=1573] in the MM.1S cell line (multiple myeloma) sensitive to dexamethasone [PubChem=5743].", "CHEBOTAEV_GR_TARGETS_UP": "Genes up-regulated in follicular epithelial stem cells after transgenic expression of GR [GeneID=2908] under control of the keratin5 (K5) [GeneID=3852] promoter.", "CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN": "Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones.", "CHEBOTAEV_GR_TARGETS_DN": "Genes down-regulated in follicular epithelial stem cells after transgenic expression of GR [GeneID=2908] under control of the keratin5 (K5) [GeneID=3852] promoter.", "CHEMELLO_SOLEUS_VS_EDL_MYOFIBERS_DN": "Genes down-regulated in type 2B (EDL) vs type 1 (soleus) myofibers.", "CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP": "Genes up-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones.", "CHEMELLO_SOLEUS_VS_EDL_MYOFIBERS_UP": "Genes up-regulated in type 1 (soleus) vs type 2B (EDL) myofibers.", "CHENG_RESPONSE_TO_NICKEL_ACETATE": "Genes down-regulated in HPL1D cells (lung epithelium) upon exposure to nickel acetate [PubChem=9756].", "CHENG_IMPRINTED_BY_ESTRADIOL": "Genes whose CpG islands became hypermethylated in breast progenitor cells pre-exposed to estradiol [PubChem=5757].", "CHENG_TAF7L_TARGETS": "Genes down-regulated in testis tissues upon knockout of TAF7L [GeneID=54457].", "CHEN_ETV5_TARGETS_SERTOLI": "Genes down-regulated in Sertoli cells from both 4 and 10 week old ETV5 [GeneID=2119] knockout mice.", "CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP": "Genes up-regulated in CD4+ [GeneID=920] T lymphocytes after stimulation with prostaglandin E2 [PubChem=5280360].", "CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN": "Genes down-regulated in CD4+ [GeneID=920] T lymphocytes after stimulation with prostaglandin E2 [PubChem=5280360].", "CHEN_HOXA5_TARGETS_6HR_DN": "Genes down-regulated 6 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line.", "CHEN_ETV5_TARGETS_TESTIS": "Genes down-regulated in testis from 4 week old ETV5 [GeneID=2119] knockout mice.", "CHEN_HOXA5_TARGETS_6HR_UP": "Genes up-regulated 6 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line.", "CHEN_HOXA5_TARGETS_9HR_DN": "Genes down-regulated 9 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line.", "CHEN_PDGF_TARGETS": "Up-regulated PDGF targets identified by a gene-trap screen.", "CHEN_HOXA5_TARGETS_9HR_UP": "Genes up-regulated 9 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line.", "CHEN_LUNG_CANCER_SURVIVAL": "Protein profiles associated with survival in lung adenocarcinoma.", "CHEOK_RESPONSE_TO_HD_MTX_UP": "Genes specifically up-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by high-dose methotrexate (HDMTX) [PubChem=4112].", "CHEOK_RESPONSE_TO_HD_MTX_DN": "Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by high-dose methotrexate (HDMTX) [PubChem=4112].", "CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP": "Up-regulated genesin the left ventricle myocardium of patients with heart failure following implantation of LVAD (left ventricular assist device).", "CHEN_LIVER_METABOLISM_QTL_CIS": "Cis-regulated expression quantitative loci (cis-eQTL) in the liver that contribute to metabolic quantitative traits (weight, fat mass, and plasma glucose and cholesterol levels).", "CHEN_LVAD_SUPPORT_OF_FAILING_HEART_DN": "Down-regulated genesin the left ventricle myocardium of patients with heart failure following implantation of LVAD (left ventricular assist device).", "CHEN_NEUROBLASTOMA_COPY_NUMBER_GAINS": "High-grade amplification (copy number, CN >= 5) detected in primary neuroblastoma samples.", "CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_HD_MTX_UP": "Genes specifically up-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and high dose methotrexate (HDMTX) [PubChem=4112].", "CHEN_METABOLIC_SYNDROM_NETWORK": "Genes forming the macrophage-enriched metabolic network (MEMN) claimed to have a causal relationship with the metabolic syndrom traits.", "CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_HD_MTX_DN": "Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and high dose methotrexate (HDMTX) [PubChem=4112].", "CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_DN": "Genes specifically down-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and low-dose methotrexate (LDMTX) [PubChem=4112].", "CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_UP": "Genes specifically up-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and low-dose methotrexate (LDMTX) [PubChem=4112].", "CHEOK_RESPONSE_TO_MERCAPTOPURINE_DN": "Genes specifically down-regulated in pediadric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490].", "CHESLER_BRAIN_D6MIT150_QTL_CIS": "Cis-regulatory QTLs (quantitative trait loci) found at the D6Mit150 region.", "CHEOK_RESPONSE_TO_MERCAPTOPURINE_UP": "Genes specifically up-regulated in pediadric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490].", "CHESLER_BRAIN_D6MIT150_QTL_TRANS": "Neurologically relevant genes modulated in brain tissue by a trans-regulatory QTL (quantitative trait locus) near D6Mit150 marker.", "CHESLER_BRAIN_HIGHEST_GENETIC_VARIANCE": "Neurologically relevant transcripts with highest variance accounted for by mouse strain (genotype) differences.", "CHESLER_BRAIN_HIGHEST_EXPRESSION": "Neurologically relevant transcripts with highest abundance fold range in brain tissue among mouse strains.", "CHESLER_BRAIN_QTL_TRANS": "Best trans-regulated quantitative trait loci (QTLs) in the mouse genome which modulate transcription in brain tissue.", "CHESLER_BRAIN_QTL_CIS": "Best cis-regulated quantitative trait loci (QTLs) in the mouse genome which modulate transcription in brain tissue.", "CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP": "Top 200 marker genes up-regulated in the 'CTNNB1' subclass of hepatocellular carcinoma (HCC); characterized by activated CTNNB1 [GeneID=1499].", "CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN": "Top 200 marker genes down-regulated in the 'CTNNB1' subclass of hepatocellular carcinoma (HCC); characterized by activated CTNNB1 [GeneID=1499].", "CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_UP": "All marker genes up-regulated in the 'interferon' subclass of hepatocellular carcinoma (HCC).", "CHIANG_LIVER_CANCER_SUBCLASS_POLYSOMY7_DN": "Marker genes down-regulated in the 'chromosome 7 polysomy' subclass of hepatocellular carcinoma (HCC); characterized by polysomy of chromosome 7 and by a lack of gains of chromosome 8q.", "CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_DN": "All marker genes down-regulated in the 'interferon' subclass of hepatocellular carcinoma (HCC).", "CHIANG_LIVER_CANCER_SUBCLASS_POLYSOMY7_UP": "Marker genes up-regulated in the 'chromosome 7 polysomy' subclass of hepatocellular carcinoma (HCC); characterized by polysomy of chromosome 7 and by a lack of gains of chromosome 8q.", "CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP": "Top 200 marker genes up-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation, high levels of serum AFP [GeneID=174], and chromosomal instability.", "CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN": "Top 200 marker genes down-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation, high levels of serum AFP [GeneID=174], and chromosomal instability.", "CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_UP": "Marker genes up-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples.", "CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN": "Marker genes down-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples.", "CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP": "Genes up-regulated in reverted NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845] which then reverted to normal cells upon stable over-expression of a dominant negative form of CDC25 [GeneID=5923]) vs normal fibroblasts.", "CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN": "Genes down-regulated in reverted NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845] which then reverted to normal cells upon stable over-expression of a dominant negative form of CDC25 [GeneID=5923]) vs normal fibroblasts.", "CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN": "Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by activated KRAS [GeneID=3845] vs those reverted to normal cells upon over-expression of a dominant negative form of CDC25 [GeneID=5923].", "CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_UP": "Genes up-regulated in NIH3T3 cells (fibroblasts) transformed by activated KRAS [GeneID=3845] vs those reverted to normal cells upon over-expression of a dominant negative form of CDC25 [GeneID=5923].", "CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP": "Genes up-regulated in transformed NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845]) vs normal cells.", "CHIARETTI_T_ALL_RELAPSE_PROGNOSIS": "Genes whose expression predicted relapse in less than 2 years after chemotherapy for adult patients with T-ALL (T cell lymphoblastic leukemia).", "CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN": "Genes down-regulated in transformed NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845]) vs normal cells.", "CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70": "Differentially expressed genes between high vs low ZAP70 [GeneID=7535] acute lymphoblastic leukemia (ALL) cases with no known molecular aberrations.", "CHIARETTI_T_ALL_REFRACTORY_TO_THERAPY": "Genes down-regulated in T cell acute lymphocytic leukemia (T-ALL) patients refractory to chemotherapy treatment.", "CHIBA_RESPONSE_TO_TSA": "Genes up-regulated in more than one of several human hepatoma cell lines by TSA [PubChem=5562].", "CHIBA_RESPONSE_TO_TSA_DN": "Cancer related genes down-regulated in any of four hepatoma cell lines following 24 h treatment with TSA [PubChem=5562].", "CHIBA_RESPONSE_TO_TSA_UP": "Cancer related genes up-regulated in any of four hepatoma cell lines following 24 h treatment with TSA [PubChem=5562].", "CHIN_BREAST_CANCER_COPY_NUMBER_DN": "Genes from common regions of losses observed in more than 15% of 148 primary breast cancer tumors.", "CHICAS_RB1_TARGETS_CONFLUENT": "Genes up-regulated in confluent IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi.", "CHIN_BREAST_CANCER_COPY_NUMBER_UP": "Genes from common regions of gains observed in more than 15% of 148 primary breast cancer tumors.", "CHNG_MULTIPLE_MYELOMA_HYPERPLOID_DN": "Protein biosynthesis, transport or catabolism genes down-regulated in hyperploid multiple myeloma (MM) compared to the non-hyperploid MM samples.", "CHNG_MULTIPLE_MYELOMA_HYPERPLOID_UP": "Protein biosynthesis, transport or catabolism genes up-regulated in hyperploid multiple myeloma (MM) compared to the non-hyperploid MM samples.", "CHICAS_RB1_TARGETS_GROWING": "Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi.", "CHOI_ATL_ACUTE_STAGE": "Acute stage-specific genes for adult T cell leukemia (ATL).", "CHOI_ATL_CHRONIC_VS_ACUTE_DN": "Genes down-regulated in adult T-cell leukemia (ATL), chronic vs acute clinical condition.", "CHICAS_RB1_TARGETS_LOW_SERUM": "Genes up-regulated in IMR90 cells (fibroblast) grown under low serum conditions and after knockdown of RB1 [GeneID=5925] by RNAi.", "CHICAS_RB1_TARGETS_SENESCENT": "Genes up-regulated in senescent IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi.", "CHOI_ATL_STAGE_PREDICTOR": "Genes used to predict the clinical stages of acute T-cell leukemia (ATL): chronic vs acute.", "CHOW_RASSF1_TARGETS_UP": "Genes up-regulated in C666-1 cells (nasopharyngeal carcinoma) by stable expression of RASSF1 [GeneID=11186].", "CHOW_RASSF1_TARGETS_DN": "Genes down-regulated in C666-1 cells (nasopharyngeal carcinoma) by stable expression of RASSF1 [GeneID=11186].", "CHO_NR4A1_TARGETS": "Genes up-regulated in RKO cells (colon cancer) after treatment with the NR4A1 [GeneID=3164] agonist, DIM-C-pPhOCH3.", "CHUNG_BLISTER_CYTOTOXICITY_DN": "Genes down-regulated in blister cells from patients with adverse drug reactions (ADR).", "CHUANG_OXIDATIVE_STRESS_RESPONSE_UP": "Genes up-regulated in MCF7 cells (breast cancer) after treatment with the oxydants: hydrogen peroxyde, menadione, and t-butyl hydroperoxyde [PubChem=784;4055;6410].", "CHUNG_BLISTER_CYTOTOXICITY_UP": "Genes up-regulated in blister cells from patients with adverse drug reactions (ADR).", "CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_UP": "Selected genes up-regulated during invasion of lymphatic vessels during metastasis.", "CHYLA_CBFA2T3_TARGETS_DN": "Genes down-regulated in immature bone marrow progenitor cells upon knock out of CBFA2T3 [GeneID=863].", "CHUANG_OXIDATIVE_STRESS_RESPONSE_DN": "Genes down-regulated in MCF7 cells (breast cancer) after treatment with the oxydants: hydrogen peroxyde, menadione, and t-butyl hydroperoxyde [PubChem=784;4055;6410].", "CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN": "Selected genes down-regulated during invasion of lymphatic vessels during metastasis.", "CLAUS_PGR_POSITIVE_MENINGIOMA_DN": "Genes down-regulated in meningioma samples positive for PGR [GeneID=5241] compared to those without the receptor.", "CHYLA_CBFA2T3_TARGETS_UP": "Genes up-regulated in immature bone marrow progenitor cells upon knock out of CBFA2T3 [GeneID=863].", "CLAUS_PGR_POSITIVE_MENINGIOMA_UP": "Genes up-regulated in meningioma samples positive for PGR [GeneID=5241] compared to those without the receptor.", "CLIMENT_BREAST_CANCER_COPY_NUMBER_DN": "Genes from the most frequent genomic losses and homozygous deletions in a panel of patients with lymph node negative breast cancer (NNBC).", "CLIMENT_BREAST_CANCER_COPY_NUMBER_UP": "Genes from the most frequent genomic gains and amplifications in a panel of patients with lymph node negative breast cancer (NNBC).", "COATES_MACROPHAGE_M1_VS_M2_UP": "Up-regulated genes distinguishing between M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophage subtypes.", "COATES_MACROPHAGE_M1_VS_M2_DN": "Down-regulated genes distinguishing between M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophage subtypes.", "COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN": "Genes down-regulated in pilocytic astrocytoma compared to glioblastoma samples.", "COLDREN_GEFITINIB_RESISTANCE_UP": "Genes up-regulated in NSCLC (non-small cell lung carcinoma) cell lines resistant to gefitinib [PubChem=123631] compared to the sensitive ones.", "COLDREN_GEFITINIB_RESISTANCE_DN": "Genes down-regulated in NSCLC (non-small cell lung carcinoma) cell lines resistant to gefitinib [PubChem=123631] compared to the sensitive ones.", "COLLER_MYC_TARGETS_DN": "Genes down-regulated in 293T (transformed fetal renal cell) upon expression of MYC [GeneID=4609].", "COLLIS_PRKDC_REGULATORS": "Proteins that regulate activity of PRKDC [GeneID=5591].", "COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_UP": "Genes up-regulated in pilocytic astrocytoma compared to glioblastoma samples.", "COLLER_MYC_TARGETS_UP": "Genes up-regulated in 293T (transformed fetal renal cell) upon expression of MYC [GeneID=4609].", "COLLIS_PRKDC_SUBSTRATES": "Substrates of PRKDC [GeneID=5591].", "COLINA_TARGETS_OF_4EBP1_AND_4EBP2": "Genes up-regulated in MEF cells (embryonic fibroblast) with double knockout of the translation repressors 4EBP1 [GeneID=1978] and 4EBP2 [GeneID=1979].", "CONRAD_GERMLINE_STEM_CELL": "Genes enriched in pluripotent adult germline stem cells.", "CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN": "Genes down-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis.", "CORONEL_RFX7_DIRECT_TARGETS_UP": "Direct target genes of the transcription factor and emerging tumor suppressor RFX7.", "CORRE_MULTIPLE_MYELOMA_UP": "Genes up-regulated in multiple myeloma (MM) bone marrow mesenchymal stem cells.", "CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP": "Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis.", "CORRE_MULTIPLE_MYELOMA_DN": "Genes down-regulated in multiple myeloma (MM) bone marrow mesenchymal stem cells.", "CONRAD_STEM_CELL": "Supplementary Table 2. Genelist comparing microarray expression profiles of spermatogonial cells, haGSCs and hES (H1) cells. Examples of expression rates of different hES cell enriched and germ cell specific genes, surface markers for germ cell selection and signal transduction in all three cell types (spermatogonial cells = SC).", "COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP": "'Late-TGFB1 signature': genes overexpressed in primary hepatocytes at a late phase of TGFB1 [GeneID=7040] treatment; is associated with a more invasive phenotype.", "COWLING_MYCN_TARGETS": "Genes down-regulated by MYCN [GeneID=4613] but not by its transactivation-defficient, trunkated form N-Myc-delta-73.", "COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN": "'Early-TGFB1 signature': genes overexpressed in primary hepatocytes at an early phase of TGFB1 [GeneID=7040] treatment; is associated with a less invasive phenotype.", "CREIGHTON_AKT1_SIGNALING_VIA_MTOR_DN": "Genes in the AKT1 [GeneID=207] pathway which depend on MTOR [GeneID=2475], sensitive to RAD001 (everolimus) [PubChem=6442177].", "CREIGHTON_AKT1_SIGNALING_VIA_MTOR_UP": "Genes in the AKT1 [GeneID=207] pathway which are independent of MTOR [GeneID=2475], insensitive to RAD001 (everolimus) [PubChem=6442177].", "CROMER_METASTASIS_DN": "Metastatic propensity markers of head and neck squamous cell carcinoma (HNSCC): down-regulated in metastatic vs non-metastatic tumors.", "CROMER_METASTASIS_UP": "Metastatic propensity markers of head and neck squamous cell carcinoma (HNSCC): up-regulated in metastatic vs non-metastatic tumors.", "CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2": "The 'group 2 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [GeneID=2099;2064].", "CROMER_TUMORIGENESIS_UP": "Tumorigenesis markers of head and neck squamous cell carcinoma (HNSCC): up-regulated in the 'early' tumors vs normal samples.", "CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1": "The 'group 1 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [GeneID=2099;2064].", "CROMER_TUMORIGENESIS_DN": "Tumorigenesis markers of head and neck squamous cell carcinoma (HNSCC): down-regulated in the 'early' tumors vs normal samples.", "CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3": "The 'group 3 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [GeneID=2099;2064].", "CROONQUIST_IL6_DEPRIVATION_DN": "Genes down-regulated in the ANBL-6 cell line (multiple myeloma, MM) after withdrawal of IL6 [GeneID=3569].", "CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4": "The 'group 4 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 but not ERBB2 [GeneID=2099;2064].", "CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5": "The 'group 5 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 but not ERBB2 [GeneID=2099;2064].", "CROONQUIST_IL6_DEPRIVATION_UP": "Genes up-regulated in the ANBL-6 cell line (multiple myeloma, MM) after withdrawal of IL6 [GeneID=3569].", "CROONQUIST_NRAS_SIGNALING_DN": "Genes down-regulated in ANBL-6 cell line (multiple myeloma, MM)  expressing a constantly active form of NRAS [GeneID=4893] off a plasmid vector compared to those grown in the presence of IL6 [GeneID=3569].", "CROONQUIST_STROMAL_STIMULATION_DN": "Genes down-regulated in ANBL-6 cell line (multiple myeloma, MM) co-cultured with bone marrow stromal cells compared to those grown in the presence of IL6 [GeneID=3569].", "CROONQUIST_NRAS_SIGNALING_UP": "Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM)  expressing a constantly active form of NRAS [GeneID=4893] off a plasmid vector compared to those grown in the presence of IL6 [GeneID=3569].", "CROONQUIST_NRAS_VS_STROMAL_STIMULATION_UP": "Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing an activated form of NRAS [GeneID=4893] off a plasmid vector compared to those co-cultured with bone marrow stromal cells.", "CROONQUIST_STROMAL_STIMULATION_UP": "Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM) co-cultured with bone marrow stromal cells compared to those grown in the presence of IL6 [GeneID=3569].", "CROSBY_E2F4_TARGETS": "Putative E2F4 [GeneID=1874] target genes identified as mitotic genes down-regulated in the LNCaP C4-2 cells (prostate cancer) at both 6 and 24 h following irradiation.", "CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN": "Genes down-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing an activated form of NRAS [GeneID=4893] off a plasmid vector compared to those co-cultured with bone marrow stromal cells.", "CUI_GLUCOSE_DEPRIVATION": "Representative genes up-regulated in MiaPaCa2 cells (pancreatic cancer) under glucose-deprived conditions.", "CURSONS_NATURAL_KILLER_CELLS": "Genes up-regulated in natural killer cells.", "CUI_TCF21_TARGETS_DN": "Genes most strongly down-regulated in kidney glomeruli isolated from TCF21 [GeneID=6943] knockout mice.", "CUI_TCF21_TARGETS_2_UP": "All significantly up-regulated genes in kidney glomeruli isolated from TCF21 [GeneID=6943] knockout mice.", "CUI_TCF21_TARGETS_UP": "Genes most strongly up-regulated in kidney glomeruli isolated from TCF21 [GeneID=6943] knockout mice.", "CUI_TCF21_TARGETS_2_DN": "All significantly down-regulated genes in kidney glomeruli isolated from TCF21 [GeneID=6943] knockout mice.", "DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_DN": "Genes down-regulated in fibroblasts expressing different mutant forms of ERCC3 [GeneID=2071]: XP/CS (xeroderma pigmentosum (XP) and Cockraine's syndrome (CS)) vs TTD (trichothiodystrophy).", "DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_UP": "Genes up-regulated in fibroblasts expressing different mutant forms of ERCC3 [GeneID=2071]: XP/CS (xeroderma pigmentosum (XP) and Cockraine's syndrome (CS)) vs TTD (trichothiodystrophy).", "DACOSTA_LOW_DOSE_UV_RESPONSE_VIA_ERCC3_XPCS_DN": "Genes down-regulated in fibroblasts expressing the XP/CS mutant form of ERCC3 [GeneID=2071], after low dose UVC irradiation.", "DACOSTA_LOW_DOSE_UV_RESPONSE_VIA_ERCC3_XPCS_UP": "Genes up-regulated in fibroblasts expressing the XP/CS mutant form of ERCC3 [GeneID=2071], after low dose UVC irradiation.", "DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_UP": "Common up-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation.", "DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN": "Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation.", "DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN": "Genes exclusively down-regulated in fibroblasts expressing the TTD mutant form of ERCC3 [GeneID=2071], after UVC irradiation.", "DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP": "Genes exclusively up-regulated in fibroblasts expressing the TTD mutant form of ERCC3 [GeneID=2071], after UVC irradiation.", "DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN": "Genes exclusively down-regulated in fibroblasts expressing the XP/CS mutant form of ERCC3 [GeneID=2071] after high dose UVC irradiation.", "DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_UP": "Genes exclusively up-regulated in fibroblasts expressing the XP/CS mutant form of ERCC3 [GeneID=2071] after high dose UVC irradiation.", "DAIRKEE_CANCER_PRONE_RESPONSE_BPA": "'Cancer prone response profile' (CPRP): genes changed in response to bisphenol A [PubChem=6623]  in epithelial cell cultures from patients at high risk of breast cancer.", "DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2": "'Cancer prone response profile' (CPRP): genes common to estradiol and bisphenol A [PubChem=5757;6623]  response of epithelial cell cultures from patients at high risk of breast cancer.", "DACOSTA_UV_RESPONSE_VIA_ERCC3_UP": "Genes up-regulated in fibroblasts expressing mutant forms of ERCC3 [GeneID=2071] after UV irradiation.", "DACOSTA_UV_RESPONSE_VIA_ERCC3_DN": "Genes down-regulated in fibroblasts expressing mutant forms of ERCC3 [GeneID=2071] after UV irradiation.", "DALESSIO_TSA_RESPONSE": "Top genes up-regulated in HEK293 cells (fibroblast) in response to trichostatin A (TSA) [PubChem=5562].", "DAIRKEE_CANCER_PRONE_RESPONSE_E2": "'Cancer prone response profile' (CPRP): genes changed in response to estradiol [PubChem=5757]  in epithelial cell cultures from patients at high risk of breast cancer.", "DANG_MYC_TARGETS_DN": "Genes down-regulated by MYC [GeneID=4609] and whose promoters are bound by MYC, according to MYC Target Gene Database.", "DANG_MYC_TARGETS_UP": "Genes up-regulated by MYC [GeneID=4609] and whose promoters are bound by MYC, according to MYC Target Gene Database.", "DANG_REGULATED_BY_MYC_UP": "Genes up-regulated by MYC [GeneID=4609], according to the MYC Target Gene Database.", "DARWICHE_PAPILLOMA_PROGRESSION_RISK": "Genes that classify progression risk of benign papilloma samples: low vs high risk.", "DANG_REGULATED_BY_MYC_DN": "Genes down-regulated by MYC [GeneID=4609], according to the MYC Target Gene Database.", "DANG_BOUND_BY_MYC": "Genes whose promoters are bound by MYC [GeneID=4609], according to MYC Target Gene Database.", "DARWICHE_PAPILLOMA_RISK_HIGH_DN": "Genes down-regulated during skin tumor progression from normal skin to high risk papilloma.", "DARWICHE_PAPILLOMA_RISK_HIGH_UP": "Genes up-regulated during skin tumor progression from normal skin to high risk papilloma.", "DARWICHE_PAPILLOMA_RISK_LOW_DN": "Genes down-regulated during skin tumor progression from low risk papilloma vs normal skin.", "DARWICHE_PAPILLOMA_RISK_LOW_UP": "Genes up-regulated during skin tumor progression from low risk papilloma vs normal skin.", "DARWICHE_SKIN_TUMOR_PROMOTER_DN": "Genes down-regulated during skin tumor progression: epidermis treated with the carcinogen DMBA [PubChem=6001] followed by 20 weekly applications of the tumor promoter TPA [PubChem=4792], compared to the untreated skin.", "DASU_IL6_SIGNALING_DN": "Genes down-regulated in normal fibroblasts in response to IL6 [GeneID=3569].", "DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN": "Genes down-regulated in squamous cell carcinoma (SCC) compared to normal skin.", "DARWICHE_SKIN_TUMOR_PROMOTER_UP": "Genes up-regulated during skin tumor progression: epidermis treated with the carcinogen DMBA [PubChem=6001] followed by 20 weekly applications of the tumor promoter TPA [PubChem=4792], compared to the untreated skin.", "DASU_IL6_SIGNALING_SCAR_DN": "Genes down-regulated in hypertrophic scar fibroblasts in response to IL6 [GeneID=3569].", "DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP": "Genes up-regulated in squamous cell carcinoma (SCC) compared to normal skin.", "DASU_IL6_SIGNALING_SCAR_UP": "Genes up-regulated in hypertrophic scar fibroblasts in response to IL6 [GeneID=3569].", "DASU_IL6_SIGNALING_UP": "Genes up-regulated in normal fibroblasts in response to IL6 [GeneID=3569].", "DAUER_STAT3_TARGETS_DN": "Top 50 genes down-regulated in A549 cells (lung cancer) expressing STAT3 [GeneID=6774] off an adenovirus vector.", "DAUER_STAT3_TARGETS_UP": "Top 50 genes up-regulated in A549 cells (lung cancer) expressing STAT3 [GeneID=6774] off an adenovirus vector.", "DAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN": "Genes down-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors.", "DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_DN": "'PAX-FKHR signature':  genes down-regulated by PAX3- or PAX7-FOXO1 [GeneID=5081;5077;2308] fusion in primary alveolar rhabdomyosarcoma(ARMS) tumors.", "DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_DN": "Genes down-regulated in RMS cells (rhabdomyosarcoma) expressing PAX3 or PAX7 fusions with FOXO1 [GeneID=5077;5081;2308] compared to the fusion negative cell lines.", "DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN": "Genes down-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors.", "DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_UP": "'PAX-FKHR signature':  genes up-regulated by PAX3- or PAX7-FOXO1 [GeneID=5081;5077;2308] fusion in primary alveolar rhabdomyosarcoma(ARMS) tumors.", "DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_UP": "Genes up-regulated in RMS cells (rhabdomyosarcoma) expressing PAX3 or PAX7 fusions with FOXO1 [GeneID=5077;5081;2308] compared to the fusion negative cell lines.", "DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP": "Genes up-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors.", "DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN": "Genes down-regulated in multiple myeloma (MM) compared to monoclonal gammopathy of uncertain significance (MGUS).", "DAVIES_MULTIPLE_MYELOMA_VS_MGUS_UP": "Genes up-regulated in multiple myeloma (MM) compared to monoclonal gammopathy of uncertain significance (MGUS).", "DAWSON_METHYLATED_IN_LYMPHOMA_TCL1": "Genes hypermethylated in at least one of the lymphoma tumors of transgenic mice overexpressing TCL1 [GeneID=8115] in germinal center B lymphocytes.", "DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP": "Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors.", "DAZARD_UV_RESPONSE_CLUSTER_G1": "Cluster G1: genes most highly up-regulated in NHEK cells (normal keratinocyte) between 6 h and 12 h after UV-B irradiation.", "DAZARD_RESPONSE_TO_UV_SCC_UP": "Genes up-regulated in SCC12B2 cells (squamous cell carcinoma) by UV-B irradiation.", "DAZARD_RESPONSE_TO_UV_SCC_DN": "Genes down-regulated in SCC12B2 cells (squamous cell carcinoma) by UV-B irradiation.", "DAZARD_RESPONSE_TO_UV_NHEK_DN": "Genes down-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation.", "DAZARD_UV_RESPONSE_CLUSTER_G2": "Cluster G2: genes increasingly up-regulated in NHEK cells (normal keratinocyte) and reaching maximum levels at 12 h and 24 h after UV-B irradiation.", "DAZARD_RESPONSE_TO_UV_NHEK_UP": "Genes up-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation.", "DAZARD_UV_RESPONSE_CLUSTER_G24": "Cluster G24: genes induced in NHEK (normal keratinocyte) but not in SCC12B2 cells (squamous cell carcinoma) by UV-B radiation.", "DAZARD_UV_RESPONSE_CLUSTER_G28": "Cluster G28: genes differentially up-regulated in NHEK (normal keratinocyte) compared to SCC12B2 cells (squamous cell carcinoma) by UV-B radiation.", "DAZARD_UV_RESPONSE_CLUSTER_G4": "Cluster G4: genes increasingly up-regulated in NHEK cells (normal keratinocyte) after 12 h time point after UV-B irradiation.", "DAZARD_UV_RESPONSE_CLUSTER_G3": "Cluster G3: genes increasingly up-regulated in NHEK cells (normal keratinocyte) after 6 h time point upon UV-B irradiation.", "DAZARD_UV_RESPONSE_CLUSTER_G5": "Cluster G5: genes up-regulated in NHEK cells (normal keratinocyte) at 3 h and 24 h time points after UV-B irradiation.", "DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS": "NF-kB-driven pro-inflammatory genes that are  negatively regulated by glucocorticoids.", "DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN": "Genes down-regulated in HEK293 cells (embryonic kidney) at 6 h, 12 h or 24 h after infection with reovirus strain T3A (known as a strong inducer of apoptosis).", "DELACROIX_RAR_TARGETS_DN": "Genes bound by RARG [GeneID=5916] and down-regulated by tretinoin (all-trans retinoic acid, ATRA) [PubChem=444795] in MEF cells (embryonic fibroblast).", "DAZARD_UV_RESPONSE_CLUSTER_G6": "Cluster G6: genes increasingly down-regulated in NHEK cells (normal keratinocyte) after UV-B irradiation.", "DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP": "Genes up-regulated in HEK293 cells (embryonic kidney) at 6 h, 12 h or 24 h after infection with reovirus strain T3A (known as a strong inducer of apoptosis).", "DELACROIX_RAR_TARGETS_UP": "Genes bound by RARG [GeneID=5916] and up-regulated by tretinoin (all-trans retinoic acid, ATRA) [PubChem=444795] in MEF cells (embryonic fibroblast).", "DELACROIX_RARG_BOUND_MEF": "Genes with DNA sequences bound by RARG [GeneID=5916] in MEF cells (embryonic fibroblast).", "DELASERNA_MYOD_TARGETS_DN": "Genes down-regulated in NIH 3T3 cells (fibroblasts) 24 h after inducing MyoD [GeneID=4654] differentiation program.", "DELASERNA_MYOD_TARGETS_UP": "Genes up-regulated in NIH 3T3 cells (fibroblasts) 24 h after inducing MyoD [GeneID=4654] differentiation program.", "DELASERNA_TARGETS_OF_MYOD_AND_SMARCA4": "Genes up-regulated in NIH 3T3 cells (fibroblasts) 24 h after inducing MYOD [GeneID=4654] which were down-regulated by dominant negative form of SMARCA4 [GeneID=6597].", "DELLA_RESPONSE_TO_TSA_AND_BUTYRATE": "Genes up-regulated in HT-29 cells (colon cancer) by the combination of trichostatin A (TSA) and sodium butyrate [PubChem=5562;5222465].", "DELPUECH_FOXO3_TARGETS_DN": "Genes down-regulated in DL23 cells (colon cancer) upon expression of an activated form of FOXO3 [GeneID=2309].", "DELACROIX_RAR_BOUND_ES": "Genes with DNA sequences bound by RARA and RARG [GeneID=5914] [GeneID=5916] in ES cells.", "DELPUECH_FOXO3_TARGETS_UP": "Genes up-regulated in DL23 cells (colon cancer) upon expression of an activated form of FOXO3 [GeneID=2309].", "DEMAGALHAES_AGING_DN": "Genes consistently underexpressed with age, based on meta-analysis of microarray data.", "DELYS_THYROID_CANCER_DN": "Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue.", "DEMAGALHAES_AGING_UP": "Genes consistently overexpressed with age, based on meta-analysis of microarray data.", "DEN_INTERACT_WITH_LCA5": "Proteins shown to interact with LCA5 [GeneID=167691] in vivo.", "DER_IFN_ALPHA_RESPONSE_DN": "Genes down-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h.", "DELYS_THYROID_CANCER_UP": "Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue.", "DER_IFN_BETA_RESPONSE_DN": "Genes down-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h.", "DER_IFN_ALPHA_RESPONSE_UP": "Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h.", "DER_IFN_BETA_RESPONSE_UP": "Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h.", "DER_IFN_GAMMA_RESPONSE_DN": "Genes down-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h.", "DESERT_EXTRACELLULAR_MATRIX_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP": "Genes up-regulated in the extracellular matrix-type subclass of hepatocellular carcinomas. Sets created as part of a metaanalysis of nine public transcriptomic datasets merged into a metadataset including 1133 human hepatocellular carcinomas obtained after curative resection. For platform descriptions of each one of the 9 datasets, see Figure 1B in D\u00e9sert et al., Hepatology (2017), 66: 1502-1518.", "DER_IFN_GAMMA_RESPONSE_UP": "Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h.", "DESERT_PERIPORTAL_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP": "Genes up-regulated in the periportal-type subclass of hepatocellular carcinomas. Sets created as part of a metaanalysis of nine public transcriptomic datasets merged into a metadataset including 1133 human hepatocellular carcinomas obtained after curative resection. For platform descriptions of each one of the 9 datasets, see Figure 1B in D\u00e9sert et al., Hepatology (2017), 66: 1502-1518.", "DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP": "Genes up-regulated in the perivenous-type subclass of hepatocellular carcinomas. Sets created as part of a metaanalysis of nine public transcriptomic datasets merged into a metadataset including 1133 human hepatocellular carcinomas obtained after curative resection. For platform descriptions of each one of the 9 datasets, see Figure 1B in D\u00e9sert et al., Hepatology (2017), 66: 1502-1518.", "DESERT_STEM_CELL_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP": "Genes up-regulated in the stem cell-type subclass of hepatocellular carcinomas. Sets created as part of a metaanalysis of nine public transcriptomic datasets merged into a metadataset including 1133 human hepatocellular carcinomas obtained after curative resection. For platform descriptions of each one of the 9 datasets, see Figure 1B in D\u00e9sert et al., Hepatology (2017), 66: 1502-1518.", "DE_YY1_TARGETS_UP": "Genes up-regulated in SaOS-2 cells (osteosarcoma) upon knockdown of YY1 [GeneID=7528] by RNAi.", "DE_YY1_TARGETS_DN": "Genes down-regulated in SaOS-2 cells (osteosarcoma) upon knockdown of YY1 [GeneID=7528] by RNAi.", "DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP": "Genes up-regulated in T-PLL cells (T-cell prolymphocytic leukemia) bearing the inv(14)/t(14:14) chromosomal aberration.", "DIERICK_SEROTONIN_FUNCTION_GENES": "Genes involved in serotonin [PubChem=5202] function, orthologs computed from D. melanogaster genes using InsParanoid resource.", "DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_DN": "Genes down-regulated in CD34+ [GeneID=947] cells isolated from bone marrow of CML (chronic myelogenous leukemia) patients, compared to those from normal donors.", "DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN": "Genes down-regulated in T-PLL cells (T-cell prolymphocytic leukemia) bearing the inv(14)/t(14:14) chromosomal aberration.", "DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP": "Genes up-regulated in CD34+ [GeneID=947] cells isolated from bone marrow of CML (chronic myelogenous leukemia) patients, compared to those from normal donors.", "DING_LUNG_CANCER_BY_MUTATION_RATE": "The lung adenocarcinoma TSP (tumor sequencing project) genes mutations in which show positive correlation with the  higher overall mutation rate.", "DING_LUNG_CANCER_MUTATED_RECURRENTLY": "The lung adenocarcinoma TSP (tumor sequencing project) genes bearing recurrent somatic mutations.", "DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER": "The lung adenocarcinoma TSP (tumor sequencing project) genes showing strong correlation between DNA copy number variation and gene expression.", "DING_LUNG_CANCER_MUTATED_FREQUENTLY": "The lung adenocarcinoma TSP (tumor sequencing project) genes with significantly higher frequencies of nonsense, splice site, and frame-shift mutations.", "DISTECHE_ESCAPED_FROM_X_INACTIVATION": "Genes that escape X inactivation.", "DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY": "The lung adenocarcinoma TSP (tumor sequencing project) genes that were found significantly mutated by at least one method.", "DIRMEIER_LMP1_RESPONSE_LATE_UP": "Cluster 3: genes up-regulated in B2264-19/3 cells (primary B lymphocytes) within 60-180 min after activation of LMP1 (an oncogene encoded by Epstein-Barr virus, EBV).", "DIRMEIER_LMP1_RESPONSE_EARLY": "Clusters 1 and 2: genes up-regulated in B2264-19/3 cells (primary B lymphocytes) within 30-60 min after activation of LMP1 (an oncogene encoded by Epstein-Barr virus, EBV).", "DIRMEIER_LMP1_RESPONSE_LATE_DN": "Cluster 4: genes down-regulated in B2264-19/3 cells (primary B lymphocytes) within 60-180 min after activation of LMP1 (an oncogene encoded by Epstein-Barr virus, EBV).", "DITTMER_PTHLH_TARGETS_DN": "Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PTHLH [GeneID=5744] by RNAi.", "DITTMER_PTHLH_TARGETS_UP": "Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PTHLH [GeneID=5744] by RNAi.", "DI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC_TUMOR_CELL_DERIVED": "Tumor-cell-derived matrisome proteins detected exclusively in highly proliferative head-and-neck squamous cell carcinoma human-to-mouse xenografts (T-Hep3) compared to dormant head-and-neck squamous cell carcinoma human-to-mouse xenografts (D-Hep3).", "DI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC": "Matrisome proteins detected exclusively in highly proliferative head-and-neck squamous cell carcinoma human-to-mouse xenografts (T-Hep3) compared to dormant head-and-neck squamous cell carcinoma human-to-mouse xenografts (D-Hep3).", "DOANE_BREAST_CANCER_CLASSES_DN": "Genes down-regulated in ER(-) / PR(-) breast tumors (do not express ESR1 and PGR [GeneID=2099;5241]) with molecular similarity to ER(+) (class A) relative to the rest of the ER(-) / PR(-) samples (class B).", "DOANE_BREAST_CANCER_CLASSES_UP": "Genes up-regulated in ER(-) / PR(-) breast tumors (do not express ESR1 and PGR [GeneID=2099;5241]) with molecular similarity to ER(+) (class A) relative to the rest of the ER(-) / PR(-) samples (class B).", "DOANE_BREAST_CANCER_ESR1_DN": "Genes down-regulated in breast cancer samples positive for ESR1 [GeneID=2099] compared to the ESR1 negative tumors.", "DOANE_BREAST_CANCER_ESR1_UP": "Genes up-regulated in breast cancer samples positive for ESR1 [GeneID=2099] compared to the ESR1 negative tumors.", "DOANE_RESPONSE_TO_ANDROGEN_UP": "Genes up-regulated in MDA-MB-453 cells (class A ER(-) [GeneID=2099] breast cancer) after exposure to the androgen R1881 [PubChem=13766].", "DOANE_RESPONSE_TO_ANDROGEN_DN": "Genes down-regulated in MDA-MB-453 cells (class A ER(-) [GeneID=2099] breast cancer) after exposure to the androgen R1881 [PubChem=13766].", "DORMOY_ELAVL1_TARGETS": "Genes down-regulated in HeLa cells upon knockdown of ELAVL1 [GeneID=1994] by RNAi.", "DONATO_CELL_CYCLE_TRETINOIN": "Genes involved in cell cycle regulation which were up-regulated in MCF-7 cells (breast cancer) by tretinoin (retinoic acid) [PubChem=444795].", "DORN_ADENOVIRUS_INFECTION_12HR_UP": "Genes up-regulated in HeLa cells (cervical carcinoma) 12 h after infection with adenovirus Ad12.", "DORN_ADENOVIRUS_INFECTION_12HR_DN": "Genes down-regulated in HeLa cells (cervical carcinoma) 12 h after infection with adenovirus Ad12.", "DORN_ADENOVIRUS_INFECTION_24HR_UP": "Genes up-regulated in HeLa cells (cervical carcinoma) 24 h after infection with adenovirus Ad12.", "DORN_ADENOVIRUS_INFECTION_24HR_DN": "Genes down-regulated in HeLa cells (cervical carcinoma) 24 h after infection with adenovirus Ad12.", "DORN_ADENOVIRUS_INFECTION_32HR_UP": "Genes up-regulated in HeLa cells (cervical carcinoma) 32 h after infection with adenovirus Ad12.", "DORN_ADENOVIRUS_INFECTION_32HR_DN": "Genes down-regulated in HeLa cells (cervical carcinoma) 32 h after infection with adenovirus Ad12.", "DORN_ADENOVIRUS_INFECTION_48HR_DN": "Genes down-regulated in HeLa cells (cervical carcinoma) 48 h after infection with adenovirus Ad12.", "DODD_NASOPHARYNGEAL_CARCINOMA_DN": "Genes down-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue.", "DORN_ADENOVIRUS_INFECTION_48HR_UP": "Genes up-regulated in HeLa cells (cervical carcinoma) 48 h after infection with adenovirus Ad12.", "DORSAM_HOXA9_TARGETS_DN": "HOXA9 [GeneID=3205] targets down-regulated in hematopoietic stem cells.", "DODD_NASOPHARYNGEAL_CARCINOMA_UP": "Genes up-regulated in nasopharyngeal carcinoma (NPC) compared to the normal tissue.", "DORSAM_HOXA9_TARGETS_UP": "HOXA9 [GeneID=3205] targets up-regulated in hematopoietic stem cells.", "DORSEY_GAB2_TARGETS": "Genes up-regulated by expression of GAB2 [GeneID=9846] in K562 cells (chronic myeloid leukemia (CML) cell line with p210 BCR-ABL [GeneID=613;25]).", "DUAN_PRDM5_TARGETS": "Direct targets of PRDM5 [GeneID=11107].", "DOUGLAS_BMI1_TARGETS_DN": "Genes down-regulated in A4573 cells (Ewing's sarcoma, ESFT) after knockdown of BMI1 [GeneID=648] by RNAi.", "DUNNE_TARGETS_OF_AML1_MTG8_FUSION_DN": "Genes down-regulated in Kasumi-1 cells (acute myeloid leukaemia (AML) with the t(8;21) translocation) after knockdown of the AML1 MTG8 fusion [GeneID=861;862] by RNAi.", "DUNNE_TARGETS_OF_AML1_MTG8_FUSION_UP": "Genes up-regulated in Kasumi-1 cells (acute myeloid leukaemia (AML) with the t(8;21) translocation) after knockdown of the AML1 MTG8 fusion [GeneID=861;862] by RNAi.", "DURAND_STROMA_NS_UP": "Genes up-regulated in the HSC non-supportive stromal cell lines.", "DOUGLAS_BMI1_TARGETS_UP": "Genes up-regulated in A4573 cells (Ewing's sarcoma, ESFT) after knockdown of BMI1 [GeneID=648] by RNAi.", "DURCHDEWALD_SKIN_CARCINOGENESIS_UP": "Genes up-regulated upon skin specific knockout of FOS [GeneID=2353] by cre-lox in the K5-SOS-F mice (express a constitutively active form of SOS1 [GeneID=6654] in the skin).", "DURAND_STROMA_S_UP": "Genes up-regulated in the HSC supportive stromal cell lines.", "DURCHDEWALD_SKIN_CARCINOGENESIS_DN": "Genes down-regulated upon skin specific knockout of FOS [GeneID=2353] by cre-lox in the K5-SOS-F mice (express a constitutively active form of SOS1 [GeneID=6654] in the skin).", "DUTTA_APOPTOSIS_VIA_NFKB": "NF-kB target genes involved in the regulation of programmed cell death.", "DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN": "Genes down-regulated in MCF7 cells (breast cancer) at 6 h of estradiol [PubChem=5757] treatment.", "DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP": "Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment.", "DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP": "Genes up-regulated in MCF7 cells (breast cancer) at 6 h of estradiol [PubChem=5757] treatment.", "EBAUER_MYOGENIC_TARGETS_OF_PAX3_FOXO1_FUSION": "Muscle development genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) but not in the RD cells (embryonal rhabdomyosarcoma, ERMS) after knockdown of PAX3-FOXO1 [GeneID=5077;2308] fusion by RNAi for 72 hr.", "DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN": "Genes down-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment.", "EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_DN": "Genes down-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) after knockdown of the PAX3-FOXO1 [GeneiD=5077;2308] fusion protein by RNAi for 72 hr.", "EHLERS_ANEUPLOIDY_DN": "Down-regulated genes in the expression signature of aneuploidy in uveal melanoma tumors: low vs high aneuploidy.", "EGUCHI_CELL_CYCLE_RB1_TARGETS": "RB1 [GeneID=5925] target genes involved in cell cycle regulation: genes down-regulated by doxorubicin [PubChem=31703] only in cells expressing RB1.", "EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP": "Genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) after knockdown of the PAX3-FOXO1 [GeneiD=5077;2308] fusion protein by RNAi for 72 hr.", "EHRLICH_ICF_SYNDROM_DN": "Down-regulated in B lymphocytes from patients with ICF syndrom caused by mutations in DNMT3B [GeneID=1789] compared to normals.", "EHLERS_ANEUPLOIDY_UP": "Up-regulated genes in the expression signature of aneuploidy in uveal melanoma tumors: low vs high aneuploidy.", "EHRLICH_ICF_SYNDROM_UP": "Up-regulated in B lymphocytes from patients with ICF syndrom caused by mutations in DNMT3B [GeneID=1789] compared to normals.", "EINAV_INTERFERON_SIGNATURE_IN_CANCER": "A gene expression signature found in a subset of cancer patients suggestive of a deregulated immune or inflammatory response.", "ELLWOOD_MYC_TARGETS_UP": "Genes up-regulated in transgenic mice expressing human MYC [GeneID=4609] in prostate.", "ELLWOOD_MYC_TARGETS_DN": "Genes down-regulated in transgenic mice expressing human MYC [GeneID=4609] in prostate.", "ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN": "Genes down-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [GeneID=3091;2034] by RNAi.", "ELVIDGE_HIF1A_TARGETS_DN": "Genes down-regulated in MCF7 cells (breast cancer) after knockdown of HIF1A [GeneID=3091] by RNAi.", "ELVIDGE_HIF1A_AND_HIF2A_TARGETS_UP": "Genes up-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [GeneID=3091;2034] by RNAi.", "ELVIDGE_HIF1A_TARGETS_UP": "Genes up-regulated in MCF7 cells (breast cancer) after knockdown of HIF1A [GeneID=3091] by RNAi.", "ELVIDGE_HYPOXIA_BY_DMOG_DN": "Genes down-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614].", "ELVIDGE_HIF2A_TARGETS_UP": "Genes up-regulated in MCF7 cells (breast cancer) after knockdown of HIF2A [GeneID=2034] by RNAi.", "ELVIDGE_HYPOXIA_BY_DMOG_UP": "Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614].", "ENGELMANN_CANCER_PROGENITORS_DN": "Down-regulated genes in the cancer progenitor (stem) cells corresponding to side population (SP) MCF7 cells (breast cancer) positive for MUC1 [GeneID=4582].", "ELVIDGE_HYPOXIA_UP": "Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions.", "ENGELMANN_CANCER_PROGENITORS_UP": "Up-regulated genes in the cancer progenitor (stem) cells corresponding to side population (SP) MCF7 cells (breast cancer) positive for MUC1 [GeneID=4582].", "ELVIDGE_HYPOXIA_DN": "Genes down-regulated in MCF7 cells (breast cancer) under hypoxia conditions.", "EPPERT_CE_HSC_LSC": "Shared human hematopoietic stem cell (HSC) and acute myeloid leukemia (AML) stem cell (LSC) genes: HSC genes that are highly expressed in LSC versus other leukemic cells.", "ENK_UV_RESPONSE_KERATINOCYTE_DN": "Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation.", "ENK_UV_RESPONSE_EPIDERMIS_UP": "Genes up-regulated in epidermis after to UVB irradiation.", "EPPERT_HSC_R": "Genes up-regulated in human hematopoietic stem cell (HSC) enriched populations compared to committed progenitors and mature cells.", "EPPERT_LSC_R": "Genes up-regulated in functionally defined leukemic stem cells (LSC) from acute myeloid leukemia (AML) patients.", "ENK_UV_RESPONSE_KERATINOCYTE_UP": "Genes up-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation.", "ENK_UV_RESPONSE_EPIDERMIS_DN": "Genes down-regulated in epidermis after to UVB irradiation.", "FAELT_B_CLL_WITH_VH3_21_UP": "Genes up-regulated in samples from B-CLL (B-cell chronic lymphocytic leukemia) with the immunoglobulin heavy chain VH3-21 gene.", "FAELT_B_CLL_WITH_VH3_21_DN": "Genes down-regulated in samples from B-CLL (B-cell chronic lymphocytic leukemia) with the immunoglobulin heavy chain VH3-21 gene.", "EPPERT_PROGENITOR": "Genes up-regulated in human hematopoietic lineage committed progenitor cells versus hematopoietic stem cells (HSC) and mature cells.", "FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN": "Genes down-regulated in B-CLL (B-cell chronic lymphocytic leukemia) patients with mutated immunoglobulin variable heavy chain (VH) genes.", "FAELT_B_CLL_WITH_VH_REARRANGEMENTS_UP": "Genes up-regulated in B-CLL (B-cell chronic lymphocytic leukemia) patients with mutated immunoglobulin variable heavy chain (VH) genes.", "FARDIN_HYPOXIA_9": "Genes in the hypoxia signature, based on analysis of nine neuroblastoma cell lines in hypoxia and normal oxygen conditions.", "FARDIN_HYPOXIA_11": "Genes in the hypoxia signature, based on analysis of 11 neuroblastoma cell lines in hypoxia and normal oxygen conditions.", "FALVELLA_SMOKERS_WITH_LUNG_CANCER": "Genes that distinguish normal from cancer (lung adenocarcinoma) samples and smokers from non-smoking subjects.", "FARMER_BREAST_CANCER_CLUSTER_2": "Cluster 2: selected proliferation and 8q amplicon genes clustered together across breast cancer samples.", "FARMER_BREAST_CANCER_CLUSTER_1": "Cluster 1: interferon, T and B lymphocyte genes clustered together across breast cancer samples.", "FARMER_BREAST_CANCER_APOCRINE_VS_BASAL": "Genes which best discriminate between two groups of breast cancer according the status of ESR1 and AR [GeneID=2099;367]: apocrine (ESR1- AR+) vs basal (ESR1- AR-).", "FARMER_BREAST_CANCER_CLUSTER_3": "Cluster 3: selected apocrine, basal and hypoxia genes clustered together across breast cancer samples.", "FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL": "Genes which best discriminate between two groups of breast cancer according to the status of ESR1 and AR [GeneID=2099;367]: apocrine (ESR1- AR+) and luminal (ESR1+ AR+).", "FARMER_BREAST_CANCER_BASAL_VS_LULMINAL": "Genes which best discriminated between two groups of breast cancer according to the status of ESR1 and AR [GeneID=2099;367]: basal (ESR1- AR-) and luminal (ESR1+ AR+).", "FARMER_BREAST_CANCER_CLUSTER_5": "Cluster 5: selected 17q21_23 amplicon genes clustered together across breast cancer samples.", "FARMER_BREAST_CANCER_CLUSTER_4": "Cluster 4: selected stromal genes clustered together across breast cancer samples.", "FARMER_BREAST_CANCER_CLUSTER_6": "Cluster 6: selected luminal genes clustered together across breast cancer samples.", "FARMER_BREAST_CANCER_CLUSTER_7": "Cluster 7: selected apocrine and luminal genes clustered together across breast cancer samples.", "FARMER_BREAST_CANCER_CLUSTER_8": "Cluster 8: selected ERBB2 [GeneID=2064] amplicon genes clustered together across breast cancer samples.", "FEKIR_HEPARG_SIDE_POP_VS_HEPARG_DN": "Genes down-regulated in the cancer stem HepaRG-SP vs HepaRG at 10 days of differentiation", "FEKIR_HEPARG_SIDE_POP_VS_HEPARG_UP": "Genes up-regulated in the cancer stem HepaRG-SP vs HepaRG at 10 days of differentiation", "FEKIR_HEPARG_SPHERE_VS_HEPARG_DN": "Genes down-regulated in the cancer stem  HepaRG-sphere vs HepaRG at 10 days of differentiation", "FEKIR_HEPARG_SPHERE_VS_HEPARG_UP": "Genes up-regulated in the cancer stem HepaRG-sphere vs HepaRG at 10 days of differentiation", "FERRANDO_LYL1_NEIGHBORS": "Nearest neighbors of LYL1 [GeneID=4066], based on the close agreement of their expression profiles with that of LYL1 in pediatric T cell acute lymphoblastic leukemia (T-ALL).", "FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN": "Top 100 genes negatively associated with T-cell acute lymphoblastic leukemia MLL T-ALL) expressing MLL-ENL fusion [GeneID=4297;4298].", "FERNANDEZ_BOUND_BY_MYC": "Genes identified by ChIP within the high-affinity group of MYC [GeneID=4609] targets.", "FERRANDO_TAL1_NEIGHBORS": "Nearest neighbors of TAL1 [GeneID=6886], based on the close agreement of their expression profiles with that of TAL1 in pediatric T cell acute lymphoblastic leukemia (T-ALL)", "FERRANDO_HOX11_NEIGHBORS": "Nearest neighbors of HOX11 [GeneID=3195], based on the close agreement of their expression profiles with that of HOX11 in pediatric T cell acute lymphoblastic leukemia (T-ALL).", "FERRARI_RESPONSE_TO_FENRETINIDE_DN": "Genes down-regulated in HUVEC cells (umbilical vein endothelium) by fenretinide [PubChem=1744].", "FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP": "Top 100 genes positively associated with T-cell acute lymphoblastic leukemia MLL T-ALL) expressing MLL-ENL fusion [GeneID=4297;4298].", "FERRARI_RESPONSE_TO_FENRETINIDE_UP": "Genes up-regulated in HUVEC cells (umbilical vein endothelium) by fenretinide [PubChem=1744].", "FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP": "Genes up-regulated in genomically unstable Ewing's sarcoma tumors compared to the stable ones.", "FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN": "Genes down-regulated in genomically unstable Ewing's sarcoma tumors compared to the stable ones.", "FIGUEROA_AML_METHYLATION_CLUSTER_2_DN": "Cluster 2 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_1_DN": "Cluster 1 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_3_DN": "Cluster 3 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_2_UP": "Cluster 2 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FEVR_CTNNB1_TARGETS_DN": "Genes down-regulated in intestinal crypt cells upon deletion of CTNNB1 [GeneID=1499].", "FIGUEROA_AML_METHYLATION_CLUSTER_1_UP": "Cluster 1 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FEVR_CTNNB1_TARGETS_UP": "Genes up-regulated in intestinal crypt cells upon deletion of CTNNB1 [GeneID=1499].", "FIGUEROA_AML_METHYLATION_CLUSTER_4_DN": "Cluster 4 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_5_DN": "Cluster 5 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_3_UP": "Cluster 3 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_4_UP": "Cluster 4 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_5_UP": "Cluster 5 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_7_DN": "Cluster 7 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_6_DN": "Cluster 6 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_7_UP": "Cluster 7 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FIGUEROA_AML_METHYLATION_CLUSTER_6_UP": "Cluster 6 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients.", "FINAK_BREAST_CANCER_SDPP_SIGNATURE": "Genes in the stroma-derived prognostic predictor of breast cancer disease outcome.", "FINETTI_BREAST_CANCER_KINOME_RED": "Genes in the red cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes.", "FINETTI_BREAST_CANCERS_KINOME_GRAY": "Genes in the gray cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes.", "FINETTI_BREAST_CANCERS_KINOME_BLUE": "Genes in the blue cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes.", "FINETTI_BREAST_CANCER_KINOME_GREEN": "Genes in the green cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes.", "FIRESTEIN_CTNNB1_PATHWAY": "Genes required for CTNNB1 [GeneID=1499] activity in DLD-1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen.", "FIRESTEIN_CTNNB1_PATHWAY_AND_PROLIFERATION": "Genes required for both proliferation and CTNNB1 [GeneID=1499] activity in DLD-1 cell (colon cancer with APC [GeneID=324] deletions).", "FISCHER_G1_S_CELL_CYCLE": "Cell cycle genes with peak expression in G1/S check point.", "FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN": "Genes down-regulated in kidney biopsies from patients with well functioning kidneys more than 1-year post transplant compared to the biopsies from normal living kidney donors.", "FIRESTEIN_PROLIFERATION": "Genes required for proliferation of DLD-1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen.", "FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS": "Genes directly bound and regulated by TP53[GeneID=7157].", "FISCHER_G2_M_CELL_CYCLE": "Cell cycle genes with peak expression in G2/M check point.", "FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP": "Genes up-regulated in kidney biopsies from patients with well functioning kidneys more than 1-year post transplant compared to the biopsies from normal living kidney donors.", "FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP": "Genes up-regulated in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant.", "FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN": "Genes downregulated in peripheral blood lymphocytes (PBL) from patients with well functioning kidneys more than 1-year post transplant compared to those from normal living kidney donors.", "FISCHER_DREAM_TARGETS": "Target genes of the DREAM complex.", "FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN": "Genes down-regulated in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant.", "FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN": "Genes down-regulated in peripheral blood lymphocytes (PBL) from patients with acute transplant rejection compared to those from patients with well functioning kidneys more than 1-year post transplant.", "FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP": "Genes upregulated in peripheral blood lymphocytes (PBL) from patients with well functioning kidneys more than 1-year post transplant compared to those from normal living kidney donors.", "FLORIO_HUMAN_NEOCORTEX": "Human-specific genes up-regulated in basal radial glia (bRG) relative to apical radial glia (aRG), and up-regulated in both aRG and bRG relative to neurons.", "FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP": "Genes up-regulated in peripheral blood lymphocytes (PBL) from patients with acute transplant rejection compared to those from patients with well functioning kidneys more than 1-year post transplant.", "FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_DN": "Genes down-regulated in basal radial glia (bRG) relative to apical radial glia (aRG), and up-regulated in both aRG and bRG relative to neurons.", "FLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_UP": "Up-regulated genes significantly associated with positive minimal residual disease (MRD) on day 46 after chemotherapy treatment of children with acute lymphoblastic leukemia (ALL).", "FONTAINE_FOLLICULAR_THYROID_ADENOMA_UP": "Genes up-regulated in follicular thyroid adenoma (FTA) compared to other thyroid tumors.", "FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN": "Genes down-regulated in follicular thyroid adenoma (FTA) compared to other thyroid tumors.", "FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP": "Genes up-regulated in basal radial glia (bRG) relative to apical radial glia (aRG), and up-regulated in both aRG and bRG relative to neurons.", "FLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_DN": "Down-regulated genes significantly associated with positive minimal residual disease (MRD) on day 46 after chemotherapy treatment of children with acute lymphoblastic leukemia (ALL).", "FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN": "Genes down-regulated in papillary thyroid carcinoma (PTC) compared to other thyroid tumors.", "FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP": "Genes up-regulated in papillary thyroid carcinoma (PTC) compared to other thyroid tumors.", "FONTAINE_THYROID_TUMOR_UNCERTAIN_MALIGNANCY_UP": "Genes up-regulated in thyroid tumors of uncertain malignancy (T-UM) compared to other thyroid tumors.", "FONTAINE_THYROID_TUMOR_UNCERTAIN_MALIGNANCY_DN": "Genes down-regulated in thyroid tumors of uncertain malignancy (T-UM) compared to other thyroid tumors.", "FOROUTAN_INTEGRATED_TGFB_EMT_DN": "Genes down-regulated in the epithelial-mesenchymal transition (EMT) upon transforming growth factor beta (TGFb) stimulation derived from multiple datasets by integrating them.", "FOROUTAN_INTEGRATED_TGFB_EMT_UP": "Genes up-regulated in the epithelial-mesenchymal transition (EMT) upon transforming growth factor beta (TGFb) stimulation derived from multiple datasets by integrating them.", "FOROUTAN_PRODRANK_TGFB_EMT_DN": "Genes down-regulated in the epithelial-mesenchymal transition (EMT) upon transforming growth factor beta (TGFb) stimulation derived from multiple datasets using a product of ranks meta-analysis approach.", "FOROUTAN_TGFB_EMT_DN": "Genes down-regulated in the epithelial-mesenchymal transition (EMT) upon transforming growth factor beta (TGFb) stimulation derived from multiple datasets by combining results from an integrative approach and a product of ranks meta-analysis approach.", "FOROUTAN_PRODRANK_TGFB_EMT_UP": "Genes up-regulated in the epithelial-mesenchymal transition (EMT) upon transforming growth factor beta (TGFb) stimulation derived from multiple datasets using a product of ranks meta-analysis approach.", "FOROUTAN_TGFB_EMT_UP": "Genes up-regulated in the epithelial-mesenchymal transition (EMT) upon transforming growth factor beta (TGFb) stimulation derived from multiple datasets by combining results from an integrative approach and a product of ranks meta-analysis approach.", "FORTSCHEGGER_PHF8_TARGETS_UP": "Genes up-regulated in HeLa cells (cervical carcinoma) upon knockdown of PHF8 [GeneID=23133] by RNAi.", "FOSTER_KDM1A_TARGETS_DN": "Genes down-regulated in ES cells (embryonic stem) heterozygotic for KDM1A [GeneID=23028] loss of function mutant compared to the homozygotic loss of the gene.", "FOSTER_KDM1A_TARGETS_UP": "Genes up-regulated in ES cells (embryonic stem) heterozygotic for KDM1A [GeneID=23028] loss of function mutant compared to the homozygotic loss of the gene.", "FOSTER_TOLERANT_MACROPHAGE_DN": "Class NT (non-tolerizable) genes: induced during the first LPS stimulation and induced at equal or greater degree in tolerant macrophages (as defined by (N+L)/(T+L) ? 1).", "FOURNIER_ACINAR_DEVELOPMENT_EARLY_DN": "Genes down-regulated early in HMEC cells (mammary epithelium) during acinar development in vitro.", "FORTSCHEGGER_PHF8_TARGETS_DN": "Genes down-regulated in HeLa cells (cervical carcinoma) upon knockdown of PHF8 [GeneID=23133] by RNAi.", "FOURNIER_ACINAR_DEVELOPMENT_EARLY_UP": "Genes up-regulated early in HMEC cells (mammary epithelium) during acinar development in vitro.", "FOURNIER_ACINAR_DEVELOPMENT_LATE_DN": "Genes down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro.", "FOURNIER_ACINAR_DEVELOPMENT_LATE_UP": "Genes up-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro.", "FOSTER_TOLERANT_MACROPHAGE_UP": "Class T (tolerizable) genes: induced during the first LPS stimulation and not re-induced or induced to a much lesser degree in tolerant macrophages (as defined by (N+L)/(T+L) > 3).", "FOURNIER_ACINAR_DEVELOPMENT_LATE_2": "Genes identified by method 2 as coordinately down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro.", "FRASOR_RESPONSE_TO_ESTRADIOL_DN": "Genes down-regulated in MCF-7 cells (breast cancer) by estradiol (E2) [PubChem=5757].", "FRASOR_RESPONSE_TO_ESTRADIOL_UP": "Genes up-regulated in MCF-7 cells (breast cancer) by estradiol (E2) [PubChem=5757].", "FRASOR_TAMOXIFEN_RESPONSE_DN": "Genes preferentially down-regulated in MCF-7 cells (breast cancer) by tamoxifen [PubChem=5376] but not by estradiol or fulvestrant (ICI 182780) [PubChem=5757;3478439].", "FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN": "Genes down-regulated in MCF-7 cells (breast cancer) by selective estrogen receptor modulators (SERM) 4-hydroxytamoxifen, raloxifene, or ICI 182780 but not by estradiol [PubChem=44959;5035;3478439;5757].", "FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_UP": "Genes up-regulated in MCF-7 cells (breast cancer) by selective estrogen receptor modulators (SERM) 4-hydroxytamoxifen, raloxifene, or ICI 182780 but not by estradiol [PubChem=44959;5035;3478439;5757].", "FRASOR_TAMOXIFEN_RESPONSE_UP": "Genes preferentially up-regulated in MCF-7 cells (breast cancer) by tamoxifen [PubChem=5376] but not by estradiol or fulvestrant (ICI 182780) [PubChem=5757;3478439].", "FREDERICK_PRKCI_TARGETS": "Genes down-regulated in H1703 cells (non-small cell lung cancer, NSCLC) after knockdown of PRKCI [GeneID=5584] by RNAi.", "FRIDMAN_SENESCENCE_DN": "Genes down-regulated in senescent cells.", "FRIDMAN_IMMORTALIZATION_DN": "Genes down-regulated in immortalized cell lines.", "FRIDMAN_SENESCENCE_UP": "Genes up-regulated in senescent cells.", "FUJII_YBX1_TARGETS_DN": "Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi.", "FUJIWARA_PARK2_HEPATOCYTE_PROLIFERATION_DN": "Genes commonly down-regulated in both non-tumorous and tumorous liver tissues of PARK2 [GeneID=5071] knockout mice.", "FUJIWARA_PARK2_IN_LIVER_CANCER_DN": "Genes down-regulated in tumorous  liver tissues from PARK2 [GeneID=5071] knockout mice compared to the normal, non-tumorous tissue from wild type mice.", "FUJIWARA_PARK2_HEPATOCYTE_PROLIFERATION_UP": "Genes commonly up-regulated in both non-tumorous and tumorous liver tissues of PARK2 [GeneID=5071] knockout mice.", "FUJII_YBX1_TARGETS_UP": "Genes up-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi.", "FUKUSHIMA_TNFSF11_TARGETS": "Genes up-regulated in RAW 264.7 cells (macrophage) upon stimulation with TNFSF11 [GeneID=8600].", "FUJIWARA_PARK2_IN_LIVER_CANCER_UP": "Genes up-regulated in tumorous  liver tissues from PARK2 [GeneID=5071] knockout mice compared to the normal, non-tumorous tissue from wild type mice.", "FUNG_IL2_SIGNALING_1": "Genes up-regulated by IL2 [GeneID=3558] in both primary thymocytes and T1 cells (primary thymocytes immortalized by Tax, an HTLV-1 encoded gene).", "FUNG_IL2_SIGNALING_2": "Genes up-regulated by IL2 [GeneID=3558] in T1 cells (primary thymocytes immortalized by Tax, an HTLV-1 encoded gene).", "FUNG_IL2_TARGETS_WITH_STAT5_BINDING_SITES": "Genes with putative STAT5 [GeneID=6777] binding sites; up-regulated by IL2 [Gene D=3558] in both primary thymocytes and T1 cells (primary thymocytes immortalized by Tax, an HTLV-1 encoded gene).", "FUNG_IL2_TARGETS_WITH_STAT5_BINDING_SITES_T1": "Genes with putative STAT5 [GeneID=6777] binding sites; up-regulated by IL2 [GeneID=3558] only in T1 cells (primary thymocytes immortalized by Tax, an HTLV-1 encoded gene).", "FU_INTERACT_WITH_ALKBH8": "Proteins identified by mass spectrometry in complexes containing ALKBH8 [GeneID=91801].", "FURUKAWA_DUSP6_TARGETS_PCI35_DN": "Genes down-regulated in PCI-35 cells (pancreatic cancer, lack endogenous DUSP6 [GeneID=1848]) upon expression of DUSP6 off an adenoviral vector.", "FURUKAWA_DUSP6_TARGETS_PCI35_UP": "Genes up-regulated in PCI-35 cells (pancreatic cancer, lack endogenous DUSP6 [GeneID=1848]) upon expression of DUSP6 off an adenoviral vector.", "FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN": "Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin, LGALS1) [GeneID=3956] compared to that with bacterial lipopolysaccharide (LPS).", "FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP": "Genes up-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin, LGALS1) [GeneID=3956] compared to that with bacterial lipopolysaccharide (LPS).", "GABRIELY_MIR21_TARGETS": "Genes significantly de-regulated (p [GeneID=406991] in A172 cells (glioma).", "GALE_APL_WITH_FLT3_MUTATED_DN": "Genes down-regulated in acute promyelocytic leukemia (APL) patients with mutated FLT3 [GeneID=2322].", "GAJATE_RESPONSE_TO_TRABECTEDIN_DN": "Genes down-regulated in HeLa cells (cervical carcinoma) by trabectedin [PubChem=3199].", "GAJATE_RESPONSE_TO_TRABECTEDIN_UP": "Genes up-regulated in HeLa cells (cervical carcinoma) by trabectedin [PubChem=3199].", "GALIE_TUMOR_ANGIOGENESIS": "Angiogenic genes up-regulated in A17 carcinomas (high vascularization) compared to the syngeneic BB1 and spontaneous tumors (little vascularization).", "GALIE_TUMOR_STEMNESS_GENES": "Stemness-related genes changed in A17 carcinomas (MTC, mesenchymal tumor cells) compared with the mesenchymal stem cells (MSC).", "GALE_APL_WITH_FLT3_MUTATED_UP": "Genes up-regulated in acute promyelocytic leukemia (APL) patients with mutated FLT3 [GeneID=2322].", "GALI_TP53_TARGETS_APOPTOTIC_DN": "Apoptosis genes down-regulated by TP53 [GeneID=7157] in HCT116 cells (colon cancer) treated with thymoquinone [PubChem=10281].", "GALI_TP53_TARGETS_APOPTOTIC_UP": "Apoptosis genes up-regulated by TP53 [GeneID=7157] in HCT116 cells (colon cancer) treated with thymoquinone [PubChem=10281].", "GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN": "Genes up-regulated in macrophages by aerolysin-related cytotoxic enterotoxin (Act) from Aeromonas hydrophila.", "GALLUZZI_PREVENT_MITOCHONDIAL_PERMEABILIZATION": "Proteins acting on mitochondria to prevent membrane permeabilization.", "GALLUZZI_PERMEABILIZE_MITOCHONDRIA": "Proteins that permeabilize mitochondria.", "GAL_LEUKEMIC_STEM_CELL_DN": "Genes down-regulated in leukemic stem cells (LSC), defined as CD34+CD38- [GeneID=947;952] cells from AML (acute myeloid leukemia patients) compared to the CD34+CD38+ cells.", "GAL_LEUKEMIC_STEM_CELL_UP": "Genes up-regulated in leukemic stem cells (LSC), defined as CD34+CD38- [GeneID=947;952] cells from AML (acute myeloid leukemia patients) compared to the CD34+CD38+ cells.", "GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN": "Genes down-regulated in the A673 cells (Ewing sarcoma) after double knockdown of both FLI1 and DAX1 [GeneID=2313;190] by RNAi.", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN": "Genes from the black module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARCIA_TARGETS_OF_FLI1_AND_DAX1_UP": "Genes up-regulated in the A673 cells (Ewing sarcoma) after double knockdown of both FLI1 and DAX1 [GeneID=2313;190] by RNAi.", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_DN": "Genes from the blue module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_UP": "Genes from the black module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BROWN_UP": "Genes from the brown module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP": "Genes from the blue module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREEN_DN": "Genes from the green module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_CYAN_UP": "Genes from the cyan module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN": "Genes from the grey module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREEN_UP": "Genes from the green module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_MAGENTA_DN": "Genes from the magenta module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_LIGHTGREEN_DN": "Genes from the lightgreen module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_UP": "Genes from the grey module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_LIGHTYELLOW_UP": "Genes from the lightyellow module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_MAGENTA_UP": "Genes from the magenta module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_PINK_DN": "Genes from the pink module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_RED_DN": "Genes from the red module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_PURPLE_DN": "Genes from the purple module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_SALMON_DN": "Genes from the salmon module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_RED_UP": "Genes from the red module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN": "Genes from the turquoise module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TAN_DN": "Genes from the tan module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_DN": "Genes from the yellow module which are dn-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP": "Genes from the turquoise module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_UP": "Genes from the yellow module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC).", "GAURNIER_PSMD4_TARGETS": "Inflammatory cytokines, chemokines and their cognate receptors up-regulated in THP-1 cells (monocyte) after treatment with PSMD4 [GeneID=5710].", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_DN": "Down-regulated genes from the set A (Fig. 5a): specific to cells expressing MLL-AF4 [GeneID=4297;4299] fusion protein alone.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_DN": "Down-regulated genes from the set B (Fig. 5a): specific signature shared by cells expressing either AF4-MLL or MLL-AF4 [GeneID=4299;4297] fusion proteins.", "GARY_CD5_TARGETS_UP": "Genes up-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP": "Up-regulated genes from the set A (Fig. 5a): specific to cells expressing MLL-AF4 [GeneID=4297;4299] fusion protein alone.", "GARY_CD5_TARGETS_DN": "Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN": "Down-regulated genes from the set C (Fig. 5a): specific to cells expressing AF4-MLL [GeneID=4299;4297] fusion protein alone.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP": "Up-regulated genes from the set B (Fig. 5a): specific signature shared by cells expressing either AF4-MLL or MLL-AF4 [GeneID=4299;4297] fusion proteins.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_D_DN": "Down-regulated genes from the set D (Fig. 5a): specific signature shared by cells expressing MLL-AF4 [GeneID=4297;4299] alone and those expressing both MLL-AF4 and AF4-MLL fusion proteins.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP": "Up-regulated genes from the set C (Fig. 5a): specific to cells expressing AF4-MLL [GeneID=4299;4297] fusion protein alone.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_D_UP": "Up-regulated genes from the set D (Fig. 5a): specific signature shared by cells expressing MLL-AF4 [GeneID=4297;4299] alone and those expressing both MLL-AF4 and AF4-MLL fusion proteins.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_DN": "Down-regulated genes from the set E (Fig. 5a): specific signature shared by cells expressing either MLL-AF4 [GeneID=4297;4299] or AF4-MLL fusion proteins alone, and those expressing both fusion proteins.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP": "Up-regulated genes from the set E (Fig. 5a): specific signature shared by cells expressing either MLL-AF4 [GeneID=4297;4299] or AF4-MLL fusion proteins alone, and those expressing both fusion proteins.", "GAUTSCHI_SRC_SIGNALING": "Genes down-regulated in A549 cells (lung cancer) after treatment with AZD0530 [PubChem=10302451], a SRC [GeneID=6714] kinase inhibitor.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN": "Down-regualted genes from the set F (Fig. 5a): specific signature shared by cells expressing AF4-MLL [GeneID=4299;4297] alone and those expressing both AF4-MLL and MLL-AF4 fusion proteins.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP": "Up-regualted genes from the set F (Fig. 5a): specific signature shared by cells expressing AF4-MLL [GeneID=4299;4297] alone and those expressing both AF4-MLL and MLL-AF4 fusion proteins.", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_DN": "Down-regulated genes from the set G (Fig. 5a): specific to cells expressing both MLL-AF4 [GeneID=4297;4299] and AF4-MLL fusion proteins.", "GAVIN_FOXP3_TARGETS_CLUSTER_P2": "Cluster P2 of genes with similar expression profiles in peripheral T ymphocytes after FOXP3 [GeneID=50943] loss of function (LOF).", "GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP": "Up-regulated genes from the set G (Fig. 5a): specific to cells expressing both MLL-AF4 [GeneID=4297;4299] and AF4-MLL fusion proteins.", "GAVIN_FOXP3_TARGETS_CLUSTER_P4": "Cluster P4 of genes with similar expression profiles in peripheral T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF).", "GAVIN_FOXP3_TARGETS_CLUSTER_P3": "Cluster P3 of genes with similar expression profiles in peripheral T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF).", "GAVIN_FOXP3_TARGETS_CLUSTER_P6": "Cluster P6 of genes with similar expression profiles in peripheral T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF).", "GAVIN_FOXP3_TARGETS_CLUSTER_P7": "Cluster P7 of genes with similar expression profiles in peripheral T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF).", "GAVIN_FOXP3_TARGETS_CLUSTER_T4": "Cluster T4 of genes with similar expression profiles in thymic T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF).", "GAVIN_IL2_RESPONSIVE_FOXP3_TARGETS_DN": "FOXP3 [GeneID=50943] target genes down-regulated in T lymphocytes after stimulation with IL2 [GeneID=3558].", "GAVIN_IL2_RESPONSIVE_FOXP3_TARGETS_UP": "FOXP3 [GeneID=50943] target genes up-regulated in T lymphocytes after stimulation with IL2 [GeneID=3558].", "GAVIN_PDE3B_TARGETS": "Genes changed in peripheral regulatory T lymphocytes that depend on PDE3B [GeneID=5140].", "GAVIN_FOXP3_TARGETS_CLUSTER_T7": "Cluster T7 of genes with similar expression profiles in thymic T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF).", "GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP": "Genes up-regulated in erythroid progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID=6223].", "GAZDA_DIAMOND_BLACKFAN_ANEMIA_MYELOID_DN": "Genes down-regulated in myeloid progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID=6223].", "GAZDA_DIAMOND_BLACKFAN_ANEMIA_MYELOID_UP": "Genes up-regulated in myeloid progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID=6223].", "GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN": "Genes down-regulated in common hematopoietic progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID=6223].", "GAZIN_EPIGENETIC_SILENCING_BY_KRAS": "Genes required for epigenetic silencing of FAS [GeneID=355] by activated KRAS [GeneID=3845] in NIH 3T3 cells, based on RNAi screen.", "GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_UP": "Genes up-regulated in common hematopoietic progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID=6223].", "GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN": "Genes down-regulated in erythroid progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID=6223].", "GEISS_RESPONSE_TO_DSRNA_DN": "Genes down-pregulated by dsRNA in GRE cells (glioma; no interferon system).", "GEISS_RESPONSE_TO_DSRNA_UP": "Genes up-pregulated by dsRNA in GRE cells (glioma; no interferon system).", "GENTILE_RESPONSE_CLUSTER_D3": "Cluster d3: genes progressively down-regulated in WS1 cells (fibroblast) through 12 h irradiation with high dose UV-C.", "GENTILE_UV_HIGH_DOSE_UP": "Selected genes up-regulated in WS1 (fibroblast) in response to irradiation with high dose UV-C.", "GENTILE_UV_HIGH_DOSE_DN": "Selected genes down-regulated in WS1 (fibroblast) in response to irradiation with high dose UV-C.", "GENTILE_UV_RESPONSE_CLUSTER_D1": "Cluster d1: genes down-regulated in WS1 cells (fibroblast) at 6 h after irradiation with high dose UV-C.", "GENTILE_UV_LOW_DOSE_DN": "Selected genes down-regulated in WS1 (fibroblast) in response to irradiation with low dose UV-C.", "GENTILE_UV_LOW_DOSE_UP": "Selected genes up-regulated in WS1 (fibroblast) in response to irradiation with low dose UV-C.", "GENTILE_UV_RESPONSE_CLUSTER_D2": "Cluster d2: genes down-regulated consistently in WS1 cells (fibroblast) between 6 h and 24 h after irradiation with high dose UV-C.", "GENTILE_UV_RESPONSE_CLUSTER_D5": "Cluster d5: genes progressively down-regulated in WS1 cells (fibroblast) through 18 h after irradiation with high dose UV-C.", "GENTILE_UV_RESPONSE_CLUSTER_D4": "Cluster d4: genes progressively down-regulated in WS1 cells (fibroblast) through 12 h after irradiation with high dose UV-C.", "GENTILE_UV_RESPONSE_CLUSTER_D6": "Cluster d6: genes progressively down-regulated in WS1 cells (fibroblast) through 18 h after irradiation with high dose UV-C.", "GENTILE_UV_RESPONSE_CLUSTER_D7": "Cluster d7: genes progressively down-regulated in WS1 cells (fibroblast) through 18 h after irradiation with high dose UV-C.", "GENTILE_UV_RESPONSE_CLUSTER_D8": "Cluster d8: genes progressively down-regulated in WS1 cells (fibroblast) through 18 h after irradiation with high dose UV-C.", "GENTLES_LEUKEMIC_STEM_CELL_DN": "Genes down-regulated in LSC (leukemic stem) cells compared to LPC (leukemia progenitor) cells from AML (acute myeloid leukemia) tumor samples.", "GENTILE_UV_RESPONSE_CLUSTER_D9": "Cluster d9: genes progressively down-regulated in WS1 cells (fibroblast) through 24 h after irradiation with high dose UV-C.", "GENTLES_LEUKEMIC_STEM_CELL_UP": "Genes up-regulated in LSC (leukemic stem) cells compared to LPC (leukemia progenitor) cells from AML (acute myeloid leukemia) tumor samples.", "GEORGES_CELL_CYCLE_MIR192_TARGETS": "Experimentally validated direct targets of MIR192 [GeneID=406967] microRNA; MIR192 caused cell cycle arrest in HCT116 cells (colon cancer).", "GERHOLD_ADIPOGENESIS_DN": "Selected genes down-regulated during differentiation of 3T3-L1 cells (fibroblast) into adipocytes in response to adipogenic hormones.", "GERHOLD_RESPONSE_TO_TZD_DN": "Genes down-regulated in 3T3-L1 cells (fibroblast) induced to differentiate to mature adipocytes and then treated with a TZD derivative AD-5075 [PubChem=128440], a PPARG [GeneID=5468] activator.", "GERHOLD_RESPONSE_TO_TZD_UP": "Genes up-regulated in 3T3-L1 cells (fibroblast) induced to differentiate to mature adipocytes and then treated with a TZD derivative AD-5075 [PubChem=128440], a PPARG [GeneID=5468] activator.", "GERHOLD_ADIPOGENESIS_UP": "Selected genes up-regulated during differentiation of 3T3-L1 cells (fibroblast) into adipocytes in response to adipogenic hormones.", "GESERICK_TERT_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblasts) with TERT [GeneID=7015] knockout, after expression of the gene off a retroviral vector.", "GHANDHI_BYSTANDER_IRRADIATION_DN": "Genes significantly (FDR < 10%) down-regulated in IMR-90 cells (fibroblast) in response to bystander irradiation.", "GHANDHI_BYSTANDER_IRRADIATION_UP": "Genes significantly (FDR < 10%) up-regulated in IMR-90 cells (fibroblast) in response to bystander irradiation.", "GERY_CEBP_TARGETS": "Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA, CEBPB, CEBPG,  and CEBPD [GeneID=1050;1051;1054;1052].", "GHANDHI_DIRECT_IRRADIATION_DN": "Genes significantly (FDR < 10%) down-regulated in IMR-90 cells (fibroblast) in response to direct irradiation.", "GHO_ATF5_TARGETS_DN": "Genes down-regulated in HEP3B cells (liver cancer) overexpressing ATF5 [GeneID=22809] off a plasmid vector.", "GHO_ATF5_TARGETS_UP": "Genes up-regulated in HEP3B cells (liver cancer) overexpressing ATF5 [GeneID=22809] off a plasmid vector.", "GEORGES_TARGETS_OF_MIR192_AND_MIR215": "Genes down-regulated in HCT116 cells (colon cancer) by expression of MIR192 or MIR215 [GeneID=406967;406997] at 24 h.", "GILMORE_CORE_NFKB_PATHWAY": "Genes encoding the NF-kB core signaling proteins.", "GHANDHI_DIRECT_IRRADIATION_UP": "Genes significantly (FDR < 10%) up-regulated in IMR-90 cells (fibroblast) in response to direct irradiation.", "GILDEA_METASTASIS": "Top genes down-regulated in metastatic (T24T) vs non-metastatic (T24) bladder cancer cell lines.", "GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN": "Genes down-regulated in metastatic breast cancer tumors having  type 2 amplification in the 20q13 region; involves MYBL2, STK6 and ZNF217 [GeneID=4605;6790;7764]", "GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_UP": "Genes up-regulated in non-metastatic breast cancer tumors having type 1 amplification in the 20q13 region; involves ZNF217 [GeneID=7764] locus only.", "GLINSKY_CANCER_DEATH_UP": "Genes whose over-expression is associated with the risk of death in multiple cancer types", "GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_UP": "Genes up-regulated in metastatic breast cancer tumors having  type 2 amplification in the 20q13 region; involves MYBL2, STK6 and ZNF217 [GeneID=4605;6790;7764]", "GLASS_IGF2BP1_CLIP_TARGETS_KNOCKDOWN_DN": "Transcripts bound to IGF2BP1 and consistently downregulated upon IGF2BP1 knockdown in various cancer derived cell lines.", "GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN": "Genes down-regulated in non-metastatic breast cancer tumors having type 1 amplification in the 20q13 region; involves ZNF217 [GeneID=7764] locus only.", "GNATENKO_PLATELET_SIGNATURE": "Top 50 most up-regulated genes in human platelet cells.", "GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION": "Oligodendrocyte core differentiation genes: up-regulated in Oli-neo cells (oligodendroglial precursor) at 10 h after treatment with PD174265, dexamethasone or isotretinoin [PubChem=4709] [PubChem=5743] [PubChem=5282379].", "GOERING_BLOOD_HDL_CHOLESTEROL_QTL_CIS": "Top scoring cis-regulated QTL (quantitative trait loci) influencing blood levels of high-density lipoprotein (HDL) cholesterol.", "GOERING_BLOOD_HDL_CHOLESTEROL_QTL_TRANS": "Top scoring trans-regulated expression quantitative trait loci (eQTL) influencing blood levels of high-density lipoprotein (HDL) cholesterol.", "GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN": "Genes down-regulated during differentiation of Oli-Neu cells (oligodendroglial precursor) in response to PD174265 [PubChem=4709].", "GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP": "Genes up-regulated during later stage of differentiation of Oli-Neu cells (oligodendroglial precursor) in response to PD174265 [PubChem=4709].", "GOLUB_ALL_VS_AML_DN": "Down-regulated genes highly correlated with acute lymphoblastic leukemia (ALL) vs acute myeloid leukemia (AML).", "GOLUB_ALL_VS_AML_UP": "Up-regulated genes highly correlated with acute lymphoblastic leukemia (ALL) vs acute myeloid leukemia (AML).", "GOLDRATH_IMMUNE_MEMORY": "'Memory genes' expressed uniquely in CD8+ [GeneID=925] memory T lymphocytes (compared with effector or naive cells)", "GOTTWEIN_TARGETS_OF_KSHV_MIR_K12_11": "Genes down-regulated in BJAB cell line (B lymphocyte) after expression of the viral microRNA miR-K12-11 which functions as an ortholog of cellular MIR155 [GeneID=406947].", "GOLDRATH_ANTIGEN_RESPONSE": "Genes up-regulated at the peak of an antigen response of naive CD8+ [GeneID=925;926] T-cells.", "GOLDRATH_HOMEOSTATIC_PROLIFERATION": "Up-regulated in CD8+ [GeneID=925] T lymphocytes undergoing homeostatic proliferation (HP) versus the naive cells; these genes are not up-regulated versus effector or memory cell population.", "GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN": "Genes down-regulated in MMH-RT cells (hepatocytes displaying an invasive, metastatic phenotype) during epithelial to mesenchymal transition (EMT).", "GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP": "Genes up-regulated in MMH-RT cells (hepatocytes displaying an invasive, metastatic phenotype) during epithelial to mesenchymal transition (EMT).", "GOUYER_TATI_TARGETS_DN": "Genes down-regulated in constitutively invasive HT-29 5M21 cells (colon cancer) vs those expressing functionally inactive TATI [GeneID=6690].", "GOUYER_TATI_TARGETS_UP": "Genes up-regulated in constitutively invasive HT-29 5M21 cells (colon cancer) vs those expressing functionally inactive TATI [GeneID=6690].", "GOUYER_TUMOR_INVASIVENESS": "Genes up-regulated in constitutively invasive HT-29 5M21 cells (colon cancer) vs the parental non-invasive cells.", "GRABARCZYK_BCL11B_TARGETS_UP": "Genes up-regulated in Jurkat cells (transformed T lymphocytes) after knockdown of BCL11B [GeneID=64919] by RNAi.", "GOZGIT_ESR1_TARGETS_UP": "Genes up-regulated in TMX2-28 cells (breast cancer) which do not express ESR1 [GeneID=2099]) compared to the parental MCF7 cells which do.", "GRADE_COLON_AND_RECTAL_CANCER_DN": "Down-regulated genes in both rectal and colon carcinoma compared to normal mucosa samples.", "GRABARCZYK_BCL11B_TARGETS_DN": "Genes down-regulated in Jurkat cells (transformed T lymphocytes) after knockdown of BCL11B [GeneID=64919] by RNAi.", "GRADE_COLON_VS_RECTAL_CANCER_DN": "Genes down-regulated in rectal but up-regulated in colon carcinoma compared to normal mucosa samples.", "GRADE_COLON_VS_RECTAL_CANCER_UP": "Genes up-regulated in rectal but down-regulated in colon carcinoma compared to normal mucosa samples.", "GRADE_COLON_AND_RECTAL_CANCER_UP": "Up-regulated genes in both rectal and colon carcinoma compared to normal mucosa samples.", "GOZGIT_ESR1_TARGETS_DN": "Genes down-regulated in TMX2-28 cells (breast cancer) which do not express ESR1 [GeneID=2099]) compared to the parental MCF7 cells which do.", "GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN": "Genes down-regulated in ME-A cells (breast cancer) undergoing apoptosis upon serum starvation (5% to 0% FCS) for 22 hr.", "GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN": "Genes down-regulated in ME-A cells (breast cancer, sensitive to apoptotic stimuli) upon serum deprivation for 22 hr in the presence of medium concentrate (MC) from ME-C cells (breast cancer, resistant to apoptotic stimuli).", "GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP": "Genes up-regulated in ME-A cells (breast cancer) undergoing apoptosis in response to doxorubicin [PubChem=31703].", "GRAHAM_CML_DIVIDING_VS_NORMAL_DIVIDING_UP": "Genes up-regulated in dividing CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients compared to the dividing cells from normal donors.", "GRAHAM_CML_DIVIDING_VS_NORMAL_DIVIDING_DN": "Genes down-regulated in dividing CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients compared to the dividing cells from normal donors.", "GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN": "Genes down-regulated in ME-A cells (breast cancer) undergoing apoptosis in response to doxorubicin [PubChem=31703].", "GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP": "Genes up-regulated in ME-A cells (breast cancer, sensitive to apoptotic stimuli) upon serum deprivation for 22 hr in the presence of medium concentrate (MC) from ME-C cells (breast cancer, resistant to apoptotic stimuli).", "GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP": "Genes up-regulated in ME-A cells (breast cancer) undergoing apoptosis upon serum starvation (5% to 0% FCS) for 22 hr.", "GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP": "Genes up-regulated in ME-A cells (breast cancer, sensitive to apoptotic stimuli) exposed to doxorubicin [PubChem=31703] in the presence of medium concentrate (MC) from ME-C cells (breast cancer, resistant to apoptotic stimuli).", "GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN": "Genes down-regulated in ME-A cells (breast cancer, sensitive to apoptotic stimuli) exposed to doxorubicin [PubChem=31703] in the presence of medium concentrate (MC) from ME-C cells (breast cancer, resistant to apoptotic stimuli).", "GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN": "Genes down-regulated in quiescent CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients.", "GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_DN": "Genes down-regulated in quiescent (G0) vs dividing (M) CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients.", "GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP": "Genes up-regulated in quiescent (G0) vs dividing (M) CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients.", "GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP": "Genes up-regulated in quiescent CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients.", "GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_DN": "Genes down-regulated in quescent CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloblastic leukemia) patients compared to the dividing cells from normal donors.", "GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_DN": "Genes down-regulated in quiescent (G0) CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients compared to the quiescent cells from normal donors.", "GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP": "Genes up-regulated in quescent CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloblastic leukemia) patients compared to the dividing cells from normal donors.", "GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP": "Genes up-regulated in quiescent (G0) CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients compared to the quiescent cells from normal donors.", "GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN": "Genes down-regulated in quiescent vs dividing CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors.", "GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP": "Genes up-regulated in quiescent vs dividing CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors.", "GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3": "Genes up-regulated in Jurkat cells (T lymphocyte) by IFN1@, and IFNB1 [GeneID=3438;3456] but not by overexpression of a constitutively active form of IRF3 [GeneID=3661].", "GRANDVAUX_IRF3_TARGETS_DN": "Genes down-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [GeneID=3661].", "GRASEMANN_RETINOBLASTOMA_WITH_6P_AMPLIFICATION": "Genes changed in retinoblastoma tumors with respect to chromosome 6p amplifications.", "GRANDVAUX_IRF3_TARGETS_UP": "Genes up-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [GeneID=3661].", "GRATIAS_RETINOBLASTOMA_16Q24": "Genes from 16q24 region up-regulated in retinoblastoma tumors with 16q24 LOH (loss of heterozygocity) compared to those without the LOH.", "GREENBAUM_E2A_TARGETS_DN": "Genes down-regulated in pre-B lymphocytes upon Cre-Lox knockout of E2A [GeneID=6929].", "GREENBAUM_E2A_TARGETS_UP": "Genes up-regulated in pre-B lymphocytes upon Cre-Lox knockout of E2A [GeneID=6929].", "GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB": "Genes identified as synthetic lethal with imatinib [PubChem=5291] in RNAi screen in K562 cells (CML, chronic myelogenous leukemia).", "GROSS_ELK3_TARGETS_DN": "Genes down-regulated in SEND cells (skin endothelium) at normal oxygen (normoxia) conditions after knockdown of ELK3 [GeneID=2004] by RNAi.", "GROSS_HIF1A_TARGETS_DN": "Genes down-regulated in SEND cells (skin endothelium) at normal oxygen (normoxia) conditions after knockdown of HIF1A [GeneID=3091] by RNAi.", "GROSS_ELK3_TARGETS_UP": "Genes up-regulated in SEND cells (skin endothelium) at normal oxygen (normoxia) conditions after knockdown of ELK3 [GeneID=2004] by RNAi.", "GROSS_HIF1A_TARGETS_UP": "Genes up-regulated in SEND cells (skin endothelium) at normal oxygen (normoxia) conditions after knockdown of HIF1A [GeneID=3091] by RNAi.", "GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN": "Genes down-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of ELK3 [GeneID=2004] and HIF1A [GeneID=3091] by RNAi.", "GRESHOCK_CANCER_COPY_NUMBER_UP": "Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples.", "GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP": "Genes up-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of ELK3 [GeneID=2004] and HIF1A [GeneID=3091] by RNAi.", "GROSS_HYPOXIA_VIA_ELK3_DN": "Genes down-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi.", "GROSS_HYPOXIA_VIA_ELK3_ONLY_DN": "Genes specifically down-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of ELK3 [GeneID=2004] by RNAi.", "GROSS_HYPOXIA_VIA_ELK3_ONLY_UP": "Genes specifically up-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of ELK3 [GeneID=2004] by RNAi.", "GROSS_HYPOXIA_VIA_HIF1A_DN": "Genes down-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of HIF1A [GeneID=3091] by RNAi.", "GROSS_HYPOXIA_VIA_HIF1A_ONLY": "Genes uniquely up-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of HIF1A [GeneID=3091] by RNAi.", "GROSS_HYPOXIA_VIA_HIF1A_UP": "Genes up-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of HIF1A [GeneID=3091] by RNAi.", "GROSS_HYPOXIA_VIA_ELK3_UP": "Genes up-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi.", "GRUETZMANN_PANCREATIC_CANCER_DN": "Genes down-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies.", "GRUETZMANN_PANCREATIC_CANCER_UP": "Genes up-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies.", "GUILLAUMOND_KLF10_TARGETS_DN": "Genes down-regulated in the liver tissue from 10 week old male mice with KLF10 [GeneID=7071] compared to wild-type littermates.", "GUENTHER_GROWTH_SPHERICAL_VS_ADHERENT_DN": "Genes down-regulated in glioblastoma cell lines displaying spherical growth (cluster-1) compared to those displaying semiadherent or adherent growth phenotype (cluster-2).", "GUENTHER_GROWTH_SPHERICAL_VS_ADHERENT_UP": "Genes up-regulated in glioblastoma cell lines displaying spherical growth (cluster-1) compared to those displaying semiadherent or adherent growth phenotype (cluster-2).", "GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS": "Expressed genes (FPKM>1) associated with high-confidence PAX3-FOXO1 sites with enhancers in primary tumors and cell lines, restricted to those within topological domain boundaries", "GRYDER_PAX3FOXO1_ENHANCERS_KO_DOWN": "Expressed genes (FPKM>1) associated with high-confidence PAX3-FOXO1 sites with enhancers in primary tumors and cell lines, restricted to those within topological domain boundaries, which are downregulated by delta log2(FPKM) < -0.2", "GUILLAUMOND_KLF10_TARGETS_UP": "Genes up-regulated in the liver tissue from 10 week old male mice with KLF10 [GeneID=7071] compared to wild-type littermates.", "GUO_HEX_TARGETS_DN": "Genes down-regulated in day 6 embryoid bodies derived from embryonic stem cells (ES) with HEX [GeneID=3087] knockout.", "GRYDER_PAX3FOXO1_TOP_ENHANCERS": "Expressed genes (FPKM>1) associated with super-high-confidence PAX3-FOXO1 sites with highly-recurrent enhancers in primary tumors and cell lines, restricted to those within topological domain boundaries", "GUO_HEX_TARGETS_UP": "Genes up-regulated in day 6 embryoid bodies derived from embryonic stem cells (ES) with HEX [GeneID=3087] knockout.", "GUO_TARGETS_OF_IRS1_AND_IRS2": "Transcripts dependent upon IRS1 and IRS2 [GeneID=3667] [GeneID=8660] for normal expression in liver.", "GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN": "Genes exclusively down-regulated in B lymphocytes from WM (Waldenstroem's macroblobulinemia) patients but with a similiar expression pattern in the normal cells and in the cells from CLL (chronic lymphocytic leukemia) patients.", "GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN": "Genes exclusively down-regulated in B lymphocytes from CLL (chronic lymphocytic leukemia) patients but with a similiar expression pattern in the normal cells and in the cells from WM (Waldenstroem's macroblobulinemia) patients.", "GUTIERREZ_MULTIPLE_MYELOMA_UP": "Genes exclusively up-regulated in plasma cells from MM (multiple myeloma) patients but with a similiar expression pattern in the normal cells and in the cells from WM (Waldenstroem's macroblobulinemia) patients.", "GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_UP": "Genes exclusively up-regulated in B lymphocytes from CLL (chronic lymphocytic leukemia) patients but with a similiar expression pattern in the normal cells and in the cells from WM (Waldenstroem's macroblobulinemia) patients.", "GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_UP": "Genes exclusively up-regulated in B lymphocytes from WM (Waldenstroem's macroblobulinemia) patients but with a similiar expression pattern in the normal cells and in the cells from CLL (chronic lymphocytic leukemia) patients.", "GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_2": "Genes exclusively up-regulated in B lymphocytes from WM (Waldenstroem's macroglobulinemia) but with a similar expression profile in MM (macroglobulinemia) and normal cells.", "GU_PDEF_TARGETS_UP": "Integrin, VEGF, Wnt and TGFbeta signaling pathway genes up-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi.", "GU_PDEF_TARGETS_DN": "Integrin, VEGF, Wnt and TGFbeta signaling pathway genes down-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi.", "GYORFFY_MITOXANTRONE_RESISTANCE": "Genes associated with resistance to mitoxantrone [PubChem=4212].", "GYORFFY_DOXORUBICIN_RESISTANCE": "Genes associated with resistance to doxorubicin [PubChem=31703].", "HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN": "Genes down-regulated in hematopoietic progenitor cells (HPC) of T lymphocyte and NK (natural killer) lineage.", "HAEGERSTRAND_RESPONSE_TO_IMATINIB": "Genes with the highest differential expression in primary tissue cultures of high grade glioma: responders vs non-responders to imatinib [PubChem=5291] treatment.", "HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP": "Genes up-regulated in hematopoietic progenitor cells (HPC) of T lymphocyte and NK (natural killer) lineage.", "HAHTOLA_CTCL_PATHOGENESIS": "Differentially expressed genes relevant to pathogenesis of cutaneous T cell lymphoma (CTCL).", "HAHTOLA_CTCL_CUTANEOUS": "Genes showing similar expression profiles in all subtypes of cutaneous T cell lymphoma (CTCL).", "HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP": "Genes up-regulated in T helper cells (defines as CD4+) isolated from patients with mucosis fungoides compared to those from normal control donors.", "HADDAD_B_LYMPHOCYTE_PROGENITOR": "Genes up-regulated in hematopoietic progenitor cells (HPC) of B lymphocyte lineage CD34+CD45RA+CD10+ [GeneID=947;5788;4311].", "HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN": "Genes down-regulated in T helper cells (defines as CD4+) isolated from patients with mucosis fungoides compared to those from normal control donors.", "HAHTOLA_MYCOSIS_FUNGOIDES_DN": "Genes down-regulated in monocytes isolated from peripheral blood samples of patients with mucosis fungoides compared to those from normal healthy donors.", "HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_DN": "Genes down-regulated in lesional skin biopsies from mycosis fundoides patients compared to the normal skin samples.", "HAHTOLA_SEZARY_SYNDROM_DN": "Genes down-regulated in monocytes isolated from peripheral blood samples of Sezary syndrom patients compared to those from healthy normal donors.", "HAHTOLA_MYCOSIS_FUNGOIDES_UP": "Genes up-regulated in monocytes isolated from peripheral blood samples of patients with mucosis fungoides compared to those from normal healthy donors.", "HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP": "Genes up-regulated in lesional skin biopsies from mycosis fundoides patients compared to the normal skin samples.", "HALMOS_CEBPA_TARGETS_DN": "Genes down-regulated in H358 cells (lung cancer) by inducible expression of CEBPA [GeneID=1050] off plasmid vector.", "HAHTOLA_SEZARY_SYNDROM_UP": "Genes up-regulated in monocytes isolated from peripheral blood samples of Sezary syndrom patients compared to those from healthy normal donors.", "HALMOS_CEBPA_TARGETS_UP": "Genes up-regulated in H358 cells (lung cancer) by inducible expression of CEBPA [GeneID=1050] off plasmid vector.", "HANN_RESISTANCE_TO_BCL2_INHIBITOR_DN": "Genes down-regulated in SCLC (small cell lung cancer) cells with acquired resistance to ABT-737 [PubChem=11228183], an inhibitor of the BCL2 [GeneID=596] family proteins.", "HAMAI_APOPTOSIS_VIA_TRAIL_DN": "Genes down-regulated in T1 cells (primary melanoma, sensitive to TRAIL [GeneID=8743]) compared to G1 cells (metastatic melanoma, resistant to TRAIL).", "HANSON_HRAS_SIGNALING_VIA_NFKB": "Genes changed by expression of activated form of HRas[GeneID=3265] in MEF cells (embryonic fibroblast) with or without p65/c-Rel complex [GeneID=5970;5966].", "HANN_RESISTANCE_TO_BCL2_INHIBITOR_UP": "Genes up-regulated in SCLC (small cell lung cancer) cells with acquired resistance to ABT-737 [PubChem=11228183], an inhibitor of the BCL2 [GeneID=596] family proteins.", "HAN_JNK_SINGALING_DN": "Genes down-regulated in 3T3 cells (fibroblast) upon activation of JNK pathway.", "HAN_JNK_SINGALING_UP": "Genes up-regulated in 3T3 cells (fibroblast) upon activation of JNK pathway.", "HAMAI_APOPTOSIS_VIA_TRAIL_UP": "Genes up-regulated in T1 cells (primary melanoma, sensitive to TRAIL [GeneID=8743]) compared to G1 cells (metastatic melanoma, resistant to TRAIL).", "HAN_SATB1_TARGETS_DN": "Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi.", "HAN_SATB1_TARGETS_UP": "Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi.", "HARRIS_BRAIN_CANCER_PROGENITORS": "Genes from the brain cancer stem (cancer stem cell, CSC) signature.", "HASEGAWA_TUMORIGENESIS_BY_RET_C634R": "Genes up-regulated in salivary, thyroid and mammary gland carcinomas developed in transgenic mice carrying RET [GeneID=5979] allele with the MEN2A mutation (C634R).", "HARRIS_HYPOXIA": "Genes known to be induced by hypoxia", "HASINA_NOL7_TARGETS_DN": "Genes down-regulated in SiHa cells (cervical carcinoma) by stable expression of NOL7 [GeneID=51406] off a plasmid vector.", "HASINA_NOL7_TARGETS_UP": "Genes up-regulated in SiHa cells (cervical carcinoma) by stable expression of NOL7 [GeneID=51406] off a plasmid vector.", "HASLINGER_B_CLL_WITH_11Q23_DELETION": "Genes changed in the B cell chronic lymphocytic leukemia (B-CLL) with deletions in the 11q23 region.", "HASLINGER_B_CLL_WITH_13Q14_DELETION": "Genes changed in the B cell chronic lymphocytic leukemia (B-CLL) with deletions in the 13q14 region.", "HASLINGER_B_CLL_WITH_17P13_DELETION": "Genes changed in the B cell chronic lymphocytic leukemia (B-CLL) with deletions in the 17p13 region.", "HASLINGER_B_CLL_WITH_6Q21_DELETION": "Genes changed in the B cell chronic lymphocytic leukemia (B-CLL) with deletions in the  6q21 region.", "HATADA_METHYLATED_IN_LUNG_CANCER_DN": "Genes with unmethylated DNA in lung cancer samples.", "HEBERT_MATRISOME_TNBC_BONE_BRAIN_LIVER_LUNG_METASTASTASES": "Matrisome proteins found in significantly higher abundance in TNBC brain, bone, liver and lung metastatases compared to normal samples.", "HEBERT_MATRISOME_TNBC_BONE_BRAIN_LUNG_LIVER_METASTASTASES_TUMOR_CELL_DERIVED": "Tumor cell-derived matrisome proteins found in significantly higher abundance in TNBC brain, bone, liver and lung metastatases compared to normal samples.", "HASLINGER_B_CLL_WITH_MUTATED_VH_GENES": "Genes changed in the B cell chronic lymphocytic leukemia (B-CLL) with mutations in the variable immunoglobulin veriable heavy chain (VH) genes.", "HASLINGER_B_CLL_WITH_CHROMOSOME_12_TRISOMY": "Genes changed in the B cell chronic lymphocytic leukemia (B-CLL) with trisomy of chromosome 12.", "HEBERT_MATRISOME_TNBC_BONE_METASTASIS": "Matrisome proteins found in significantly higher abundance in TNBC bone metastasis niche compared to TNBC brain, liver and lung metastatic niches.", "HEBERT_MATRISOME_TNBC_BONE_METASTASIS_TUMOR_CELL_DERIVED": "Tumor cell-derived matrisome proteins found in significantly higher abundance in TNBC bone metastasis niche compared to TNBC brain, liver and lung metastatic niches.", "HATADA_METHYLATED_IN_LUNG_CANCER_UP": "Genes with hypermethylated DNA in lung cancer samples.", "HEBERT_MATRISOME_TNBC_BRAIN_METASTASIS": "Matrisome proteins found in significantly higher abundance in TNBC brain metastasis niche compared to TNBC bone, liver and lung metastatic niches.", "HEBERT_MATRISOME_TNBC_BRAIN_METASTASIS_TUMOR_CELL_DERIVED": "Tumor cell-derived matrisome proteins found in significantly higher abundance in TNBC brain metastasis niche compared to TNBC bone, liver and lung metastatic niches.", "HEBERT_MATRISOME_TNBC_LUNG_METASTASIS_TUMOR_CELL_DERIVED": "Tumor cell-derived matrisome proteins found in significantly higher abundance in TNBC lung metastasis niche compared to TNBC brain, liver and bone metastatic niches.", "HEBERT_MATRISOME_TNBC_LIVER_METASTASIS": "Matrisome proteins found in significantly higher abundance in TNBC liver metastasis niche compared to TNBC brain, lung and bone metastatic niches.", "HEBERT_MATRISOME_TNBC_LUNG_METASTASIS": "Matrisome proteins found in significantly higher abundance in TNBC lung metastasis niche compared to TNBC bone, liver and brain metastatic niches.", "HEDVAT_ELF4_TARGETS_UP": "Genes up-regulated in HEL cells (erythroleukemia) upon expression of ELF4 [GeneID=2000].", "HECKER_IFNB1_TARGETS": "Genes transcriptionally modulated in the blood of multiple sclerosis patients in response to subcutaneous treatment with recombinant IFNB1 [GeneID=3456].", "HEIDENBLAD_AMPLICON_12P11_12_DN": "Down-regulated genes whose expression is associated with amplification of the 12p11-12 chromosome in pancreatic cancer cell lines.", "HEDENFALK_BREAST_CANCER_BRACX_DN": "Down-regulated genes distinguishing between two groups of non-BRCA1/BRCA2 [GeneID=672;675] breast tumors (BRACx): group A vs group B.", "HEIDENBLAD_AMPLIFIED_IN_BONE_CANCER": "Genes from selected recurrently amplified regions in bone tissue tumors with supernumerary  ring chromosomes.", "HEIDENBLAD_AMPLICON_12P11_12_UP": "Up-regulated genes whose expression is associated with amplification of the 12p11-12 chromosome in pancreatic cancer cell lines.", "HEIDENBLAD_AMPLICON_8Q24_UP": "Up-regulated genes whose expression is associated with amplification of the 8q24 chromosome region in pancreatic cancer cell lines.", "HEIDENBLAD_AMPLIFIED_IN_SOFT_TISSUE_CANCER": "Genes from selected recurrently amplified regions in soft tissue tumors with supernumerary  ring chromosomes.", "HEIDENBLAD_AMPLIFIED_IN_PANCREATIC_CANCER": "Genes amplified and up-regulated more than twofold in at least two out of 10 pancreatic cancer cell lines studied.", "HEIDENBLAD_AMPLICON_8Q24_DN": "Down-regulated genes whose expression is associated with amplification of the 8q24 chromosome region in pancreatic cancer cell lines.", "HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS": "Genes down-regulated in  tumor-conditioned vs quiescent endothelial cells and up-regulated upon treatment with decitabine and TSA [PubChem=451668;5562].", "HEDENFALK_BREAST_CANCER_BRACX_UP": "Up-regulated genes distinguishing between two groups of non-BRCA1/BRCA2 [GeneID=672;675] breast tumors (BRACx): group A vs group B.", "HELLER_HDAC_TARGETS_DN": "Genes down-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562].", "HELLER_SILENCED_BY_METHYLATION_DN": "Genes down-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].", "HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN": "Genes down-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562].", "HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP": "Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562].", "HELLER_HDAC_TARGETS_UP": "Genes up-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562].", "HENDRICKS_SMARCA4_TARGETS_DN": "Genes down-regulated in ALAB cells (breast cancer) upon reintroduction of SMARCA4 [GeneID=6597] expressed off adenoviral vector.", "HENDRICKS_SMARCA4_TARGETS_UP": "Genes up-regulated in ALAB cells (breast cancer) upon reintroduction of SMARCA4 [GeneID=6597] expressed off adenoviral vector.", "HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_DN": "Genes down-regulated in MDA-MB-231 cells (breast cancer, mutated TP53 [GeneID=7157]) undergoing aberrant mitosis and necrosis after treatment with 2 nM docetaxel [PubChem=148124].", "HELLER_SILENCED_BY_METHYLATION_UP": "Genes up-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].", "HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP": "Genes up-regulated in MDA-MB-231 cells (breast cancer, mutated TP53 [GeneID=7157]) undergoing aberrant mitosis and necrosis after treatment with 2 nM docetaxel [PubChem=148124].", "HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_4NM_DN": "Genes down-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing aberrant mitosis and necrosis after treatment wiht 4 nM docetaxel [PubChem=148124].", "HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_4NM_UP": "Genes up-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing aberrant mitosis and necrosis after treatment wiht 4 nM docetaxel [PubChem=148124].", "HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_UP": "Genes up-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124].", "HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_DN": "Genes down-regulated in MDA-MB-231 cells (breast cancer, mutated TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124].", "HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_DN": "Genes down-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124].", "HESSON_TUMOR_SUPPRESSOR_CLUSTER_3P21_3": "Genes in the tumor suppressor cluster of the 3p21.3 region.", "HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_UP": "Genes up-regulated in MDA-MB-231 cells (breast cancer, mutated TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124].", "HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP": "Genes up-regulated in hematopoietic precursor cells conditionally expressing HOXA9 and MEIS1 [GeneID=3205;4211].", "HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN": "Genes down-regulated in hematopoietic precursor cells conditionally expressing HOXA9 and MEIS1 [GeneID=3205;4211].", "HE_PTEN_TARGETS_DN": "Genes down-regulated in the intestine after the tissue specific knockout of PTEN [GeneID=5728] by Cre-lox.", "HE_PTEN_TARGETS_UP": "Genes up-regulated in the intestine after the tissue specific knockout of PTEN [GeneID=5728] by Cre-lox.", "HILLION_HMGA1B_TARGETS": "Genes changed in Rat1a cells (fibroblasts) by overexpression of  HMGA1 isoform b [GeneID=3159] off a plasmid vector.", "HILLION_HMGA1_TARGETS": "Genes changed in Rat1a cells (fibroblasts) by overexpression of  HMGA1 isoform a [GeneID=3159] off a plasmid vector.", "HINATA_NFKB_TARGETS_KERATINOCYTE_DN": "Genes down-regulated in primary keratinocytes by expression of p50 (NFKB1) and p65 (RELA) [GeneID=4790;5970] components of NFKB.", "HINATA_NFKB_TARGETS_FIBROBLAST_UP": "Genes up-regulated in primary fibroblast cells by expression of p50 (NFKB1) and p65  (RELA) [GeneID=4790;5970] components of NFKB.", "HINATA_NFKB_TARGETS_KERATINOCYTE_UP": "Genes up-regulated in primary keratinocytes by expression of p50 (NFKB1) and p65 (RELA) [GeneID=4790;5970] components of NFKB.", "HOEGERKORP_CD44_TARGETS_DIRECT_DN": "Genes directly down-regulated by CD44 [GeneID=960] stimulation of B lymphocytes.", "HOEBEKE_LYMPHOID_STEM_CELL_DN": "Genes down-regulated in the common lymphoid progenitor (CLP, defined as CD34+CD38-CD7+ [GeneID=947;952;924]) compared to a multipotent cord blood cell (defined as CD34+CD38+CD7-).", "HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN": "Down-regulated genes in the cancer gene signature, representing a gene signature of cellular transformation.", "HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP": "Up-regulated genes in the cancer gene signature, representing a gene signature of cellular transformation.", "HOEBEKE_LYMPHOID_STEM_CELL_UP": "Genes up-regulated in the common lymphoid progenitor (CLP, defined as CD34+CD38-CD7+ [GeneID=947;952;924]) compared to a multipotent cord blood cell (defined as CD34+CD38+CD7-).", "HOEGERKORP_CD44_TARGETS_TEMPORAL_UP": "Genes temporally up-regulated by CD44 [GeneID=960] stimulation of B lymphocytes.", "HOEGERKORP_CD44_TARGETS_DIRECT_UP": "Genes directly up-regulated by CD44 [GeneID=960] stimulation of B lymphocytes.", "HOEGERKORP_CD44_TARGETS_TEMPORAL_DN": "Genes temporally down-regulated by CD44 [GeneID=960] stimulation of B lymphocytes.", "HOELZEL_NF1_TARGETS_DN": "Genes down-regulated in SH-SY5Y cells (neuroblastoma) after knockdown of NF1 [GeneID=4763] by RNAi.", "HOELZEL_NF1_TARGETS_UP": "Genes up-regulated in SH-SY5Y cells (neuroblastoma) after knockdown of NF1 [GeneID=4763] by RNAi.", "HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_DN": "Genes down-regulated during differentiation of immature to mature B lymphocyte.", "HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_UP": "Genes up-regulated during differentiation of immature to mature B lymphocyte.", "HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN": "Genes down-regulated during differentiation from large pre-BII to small pre-BII lymphocyte.", "HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP": "Genes up-regulated during differentiation from pre-BI to large pre-BII lymphocyte.", "HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN": "Genes down-regulated during differentiation from pre-BI to large pre-BII lymphocyte.", "HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN": "Genes down-regulated during differentiation from small pre-BII to immature B lymphocyte.", "HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP": "Genes up-regulated during differentiation from small pre-BII to immature B lymphocyte.", "HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP": "Genes up-regulated during differentiation from large pre-BII to small pre-BII lymphocyte.", "HOFFMAN_CLOCK_TARGETS_DN": "Genes down-regulated in MCF7 cells (breast cancer) upon knockdown of CLOCK [GeneID=9575] by RNAi that also belong to the highest confidence network (according to Ingenuity Pathway Analysis).", "HOFFMAN_CLOCK_TARGETS_UP": "Genes up-regulated in MCF7 cells (breast cancer) upon knockdown of CLOCK [GeneID=9575] by RNAi that also belong to the highest confidence network (according to Ingenuity Pathway Analysis).", "HOFMANN_CELL_LYMPHOMA_DN": "Genes down-regulated in lymph nodes from patients with mantle cell lymphoma (MCL) compared to the non-malignant hyperplastic lymph nodes.", "HOFMANN_CELL_LYMPHOMA_UP": "Genes up-regulated in lymph nodes from patients with mantle cell lymphoma (MCL) compared to the non-malignant hyperplastic lymph nodes.", "HOFMANN_MYELODYSPLASTIC_SYNDROM_HIGH_RISK_UP": "Genes up-regulated in bone marrow hematopoietic stem cells (HSC, CD34+ [GeneID=947]) from patients with high risk of myelodysplastic syndrome (MDS) compared with healthy controls.", "HOFMANN_MYELODYSPLASTIC_SYNDROM_HIGH_RISK_DN": "Genes down-regulated in bone marrow hematopoietic stem cells (HSC, CD34+ [GeneID=947]) from patients with high risk of myelodysplastic syndrome (MDS) compared with healthy controls.", "HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_UP": "Genes up-regulated in bone marrow hematopoietic stem cells (HSC, CD34+ [GeneID=947]) from patients with low risk of myelodysplastic syndrome (MDS) compared with healthy controls.", "HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_DN": "Genes down-regulated in bone marrow hematopoietic stem cells (HSC, CD34+ [GeneID=947]) from patients with low risk of myelodysplastic syndrome (MDS) compared with healthy controls.", "HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_DN": "Genes down-regulated in bone marrow hematopoietic stem cells (HSC, CD34+ [GeneID=947]) from patients with high risk of myelodysplastic syndrom (MDS) compared to the low risk patients.", "HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_UP": "Genes up-regulated in bone marrow hematopoietic stem cells (HSC, CD34+ [GeneID=947]) from patients with high risk of myelodysplastic syndrom (MDS) compared to the low risk patients.", "HOLLEMAN_ASPARAGINASE_RESISTANCE_ALL_DN": "Genes distinguishing asparaginase resistant and sensitive ALL (B- and T-lineage ALL); here - genes down-regulated in the drug resistant samples.", "HOLLEMAN_ASPARAGINASE_RESISTANCE_ALL_UP": "Genes distinguishing asparaginase resistant and sensitive ALL (B- and T-lineage ALL); here - genes up-regulated in the drug resistant samples.", "HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_DN": "Genes distinguishing asparaginase resistant and sensitive B-lineage ALL; here - genes down-regulated in the drug resistant samples.", "HOLLEMAN_DAUNORUBICIN_ALL_DN": "Genes distinguishing daunorubicin [PubChem=30323] resistant and sensitive ALL (B- and T-lineage ALL); here - genes down-regulated in the drug resistant samples.", "HOLLEMAN_DAUNORUBICIN_ALL_UP": "Genes distinguishing daunorubicin [PubChem=30323] resistant and sensitive ALL (B- and T-lineage ALL); here - genes up-regulated in the drug resistant samples.", "HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_UP": "Genes distinguishing asparaginase resistant and sensitive B-lineage ALL; here - genes up-regulated in the drug resistant samples.", "HOLLEMAN_DAUNORUBICIN_B_ALL_DN": "Genes distinguishing daunorubicin [PubChem=30323] resistant and sensitive B-lineage ALL; here - genes down-regulated in the drug resistant samples.", "HOLLEMAN_DAUNORUBICIN_B_ALL_UP": "Genes distinguishing daunorubicin [PubChem=30323] resistant and sensitive B-lineage ALL; here - genes up-regulated in the drug resistant samples.", "HOLLEMAN_PREDNISOLONE_RESISTANCE_ALL_DN": "Genes distinguishing prednisolone [PubChem=5755] resistant and sensitive ALL (B- and T-lineage ALL); here - genes down-regulated in the drug resistant samples.", "HOLLEMAN_PREDNISOLONE_RESISTANCE_ALL_UP": "Genes distinguishing prednisolone [PubChem=5755] resistant and sensitive ALL (B- and T-lineage ALL); here - genes up-regulated in the drug resistant samples.", "HOLLEMAN_PREDNISOLONE_RESISTANCE_B_ALL_DN": "Genes distinguishing prednisolone [PubChem=5755] resistant and sensitive B-lineage ALL; here - genes down-regulated in the drug resistant samples.", "HOLLEMAN_VINCRISTINE_RESISTANCE_ALL_DN": "Genes distinguishing vincristine [PubChem=5978] resistant and sensitive ALL (B- and T-lineage ALL); here - genes down-regulated in the drug resistant samples.", "HOLLEMAN_VINCRISTINE_RESISTANCE_ALL_UP": "Genes distinguishing vincristine [PubChem=5978] resistant and sensitive ALL (B- and T-lineage ALL); here - genes up-regulated in the drug resistant samples.", "HOLLEMAN_PREDNISOLONE_RESISTANCE_B_ALL_UP": "Genes distinguishing prednisolone [PubChem=5755] resistant and sensitive B-lineage ALL; here - genes up-regulated in the drug resistant samples.", "HOLLEMAN_VINCRISTINE_RESISTANCE_B_ALL_DN": "Genes distinguishing vincristine [PubChem=5978] resistant and sensitive B-lineage ALL; here - genes down-regulated in the drug resistant samples.", "HOLLEMAN_VINCRISTINE_RESISTANCE_B_ALL_UP": "Genes distinguishing vincristine [PubChem=5978] resistant and sensitive B-lineage ALL; here - genes up-regulated in the drug resistant samples.", "HOLLERN_ADENOMYOEPITHELIAL_BREAST_TUMOR": "Genes that have high expression in mammary tumors of adenomyoepithelial histology.", "HOLLERN_MICROACINAR_BREAST_TUMOR_DN": "Genes that have low expression in mammary tumors of microacinar histology.", "HOLLERN_EMT_BREAST_TUMOR_UP": "Genes that are highly expressed in mammary tumors of epithelial-mesenchymal transition (EMT) histology.", "HOLLERN_EMT_BREAST_TUMOR_DN": "Genes that that have low expression in mammary tumors of epithelial-mesenchymal transition (EMT) histology.", "HOLLERN_PAPILLARY_BREAST_TUMOR": "Genes that have high expression in paplillary mammary tumors.", "HOLLERN_MICROACINAR_BREAST_TUMOR_UP": "Genes that have high expression in mammary tumors of microacinar histology.", "HOLLERN_SOLID_NODULAR_BREAST_TUMOR_DN": "Genes that have low expression in mammary tumors of solid nodular histology.", "HOLLERN_SOLID_NODULAR_BREAST_TUMOR_UP": "Genes that have high expression in mammary tumors of solid nodular histology.", "HONMA_DOCETAXEL_RESISTANCE": "Genes up-regulated in MCF7-ADR cell line (breast cancer) resistant to docetaxel [PubChem=148124].", "HONRADO_BREAST_CANCER_BRCA1_VS_BRCA2": "Genes distinguishing between breast cancer tumors bearing mutations in BRCA1 [GeneID=672] and those with mutated BRCA2 [GeneID=675].", "HOLLERN_SQUAMOUS_BREAST_TUMOR": "Genes that have high expression in mammary tumors of squamous epithelium histology.", "HOLLMANN_APOPTOSIS_VIA_CD40_UP": "Genes up-regulated in DLBCL (diffuse large B-cell lymphoma) cell lines sensitive to stimulation of CD40 [GeneID=958] relative to the resistant ones.", "HOLLMANN_APOPTOSIS_VIA_CD40_DN": "Genes down-regulated in DLBCL (diffuse large B-cell lymphoma) cell lines sensitive to stimulation of CD40 [GeneID=958] relative to the resistant ones.", "HOOI_ST7_TARGETS_DN": "Genes down-regulated in PC-3 cells (prostate cancer) stably expressing ST7 [GeneID=7982] off a plasmid vector.", "HOOI_ST7_TARGETS_UP": "Genes up-regulated in PC-3 cells (prostate cancer) stably expressing ST7 [GeneID=7982] off a plasmid vector.", "HOQUE_METHYLATED_IN_CANCER": "Genes whose DNA was methylated both in primary tumors and across a panel of cancer cell lines.", "HORTON_SREBF_TARGETS": "Genes up-regulated in liver from mice transgenic for SREBF1 or SREBF2 [GeneID=6720] [GeneID=6721] and down-regulated in mice lacking SCAP [GeneID=22937].", "HORIUCHI_WTAP_TARGETS_UP": "Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi.", "HORIUCHI_WTAP_TARGETS_DN": "Genes down-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi.", "HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN": "Genes whose expression correlated with lower risk of late recurrence of hepatocellular carcinoma (HCC).", "HOSHIDA_LIVER_CANCER_SUBCLASS_S2": "Genes from 'subtype S2' signature of hepatocellular carcinoma (HCC): proliferation, MYC and AKT1 [GeneID=4609;207] activation.", "HOSHIDA_LIVER_CANCER_SUBCLASS_S1": "Genes from 'subtype S1' signature of hepatocellular carcinoma (HCC): aberrant activation of the WNT signaling pathway.", "HOSHIDA_LIVER_CANCER_SURVIVAL_UP": "Survival signature genes defined in adjacent liver tissue: genes correlated with poor survival of hepatocellular carcinoma (HCC) patients.", "HOSHIDA_LIVER_CANCER_SURVIVAL_DN": "Survival signature genes defined in adjacent liver tissue: genes correlated with good survival of hepatocellular carcinoma (HCC) patients.", "HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_UP": "Genes whose expression correlated with higher risk of late recurrence of hepatocellular carcinoma (HCC).", "HOUSTIS_ROS": "Genes known to modulate ROS or whose expression changes in response to ROS", "HOSHIDA_LIVER_CANCER_SUBCLASS_S3": "Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation.", "HOWLIN_CITED1_TARGETS_1_DN": "Genes down-regulated in mammary glands from the CITED1 [GeneID=4435] knockout mice: homozygotic vs. heterozygotic animals.", "HOWLIN_CITED1_TARGETS_1_UP": "Genes up-regulated in mammary glands from the CITED1 [GeneID=4435] knockout mice: homozygotic vs. heterozygotic animals.", "HOWLIN_CITED1_TARGETS_2_DN": "Genes down-regulated in mammary glands from the CITED1 [GeneID=4435] knockout mice: homozygotic vs wild type (WT) animals.", "HO_LIVER_CANCER_VASCULAR_INVASION": "Gene expression signature of vascular invasion of hepatocellular carcinoma (HCC).", "HOWLIN_CITED1_TARGETS_2_UP": "Genes up-regulated in mammary glands from the CITED1 [GeneID=4435] knockout mice: homozygotic vs wild type (WT) animals.", "HOWLIN_PUBERTAL_MAMMARY_GLAND": "Genes up-regulated in pubertal mammary glands compared to mammary glands from other developmental stages.", "HOUNKPE_HOUSEKEEPING_GENES": "List of 1130 human and mouse housekeeping genes. This list shows the overlap of human genes stably expressed across 52 tissues and cells types and mouse genes with at least one of their transcripts expressed across 14 tissues and cells types.", "HUANG_AML_LSC47": "Genes up-regulated in AML leukemia stem cells (LSC) and predictive for outcome in AML", "HUANG_DASATINIB_RESISTANCE_DN": "Genes whose expression negatively correlated with resistance of breast cancer cell lines to dasatinib [PubChem=3062316].", "HSIAO_LIVER_SPECIFIC_GENES": "Liver selective genes", "HUANG_FOXA2_TARGETS_DN": "Genes down-regulated in H358 cells (lung cancer) by inducible expression of FOXA2 [GeneID=3170] in a Tet-off system.", "HSIAO_HOUSEKEEPING_GENES": "Housekeeping genes identified as expressed across 19 normal tissues.", "HUANG_DASATINIB_SENSITIVITY_UP": "Genes whose expression positively correlated with sensitivity of breast cancer cell lines to dasatinib [PubChem=3062316].", "HUANG_FOXA2_TARGETS_UP": "Genes up-regulated in H358 cells (lung cancer) by inducible expression of FOXA2 [GeneID=3170] in a Tet-off system.", "HUANG_GATA2_TARGETS_DN": "Genes down-regulated in G1ME cells (megakaryocyte/erythroid progenitor lacking GATA1 [GeneID=2623]) upon knockdown of GATA2 [GeneID=2624] by RNAi.", "HUANG_GATA2_TARGETS_UP": "Genes up-regulated in G1ME cells (megakaryocyte/erythroid progenitor lacking GATA1 [GeneID=2623]) upon knockdown of GATA2 [GeneID=2624] by RNAi.", "HUI_MAPK14_TARGETS_UP": "Genes up-regulated in fetal liver (days E13.5 and E15.5) samples from embryo-specific Cre-lox knockout of MAPK14 [GeneID=1432].", "HUMMEL_BURKITTS_LYMPHOMA_DN": "Down-regulated genes constituting the molecular signature of Burkitt 's lymphoma.", "HUMMEL_BURKITTS_LYMPHOMA_UP": "Up-regulated genes constituting the molecular signature of Burkitt 's lymphoma.", "HUMMERICH_BENIGN_SKIN_TUMOR_DN": "Genes down-regulated in benign skin tumors (papilloma) induced by treatment with DMBA and TPA [PubChem=6001;4792] chemicals in the two stage skin carcinogenesis model.", "HUMMERICH_BENIGN_SKIN_TUMOR_UP": "Genes up-regulated in benign skin tumors (papilloma) induced by treatment with DMBA and TPA [PubChem=6001;4792] chemicals in the two stage skin carcinogenesis model.", "HUMMERICH_MALIGNANT_SKIN_TUMOR_UP": "Genes up-regulated in malignant skin tumors (squamous cell carcinoma, SCC) formed by treatment with DMBA and TPA [PubChem=6001;4792] in the two stage skin carcinogenesis model.", "HUMMERICH_MALIGNANT_SKIN_TUMOR_DN": "Genes down-regulated in malignant skin tumors (squamous cell carcinoma, SCC) formed by treatment with DMBA and TPA [PubChem=6001;4792] in the two stage skin carcinogenesis model.", "HUMMERICH_SKIN_CANCER_PROGRESSION_DN": "Selected genes down-regulated during progression through benign to malignant skin tumors formed by treatment with DMBA and TPA [PubChem=6001;4792] chemicals in the two stage skin carcinogenesis model.", "HUMMERICH_SKIN_CANCER_PROGRESSION_UP": "Selected genes up-regulated during progression through benign to malignant skin tumors formed by treatment with DMBA and TPA [PubChem=6001;4792] chemicals in the two stage skin carcinogenesis model.", "HUNSBERGER_EXERCISE_REGULATED_GENES": "Exercise regulated genes in hyppocampus.", "HUPER_BREAST_BASAL_VS_LUMINAL_DN": "Genes down-regulated in basal mammary epithelial cells compared to the luminal ones.", "HUPER_BREAST_BASAL_VS_LUMINAL_UP": "Genes up-regulated in basal mammary epithelial cells compared to the luminal ones.", "HU_ANGIOGENESIS_UP": "Up-regulated genes that separate angiogenic from non-angiogenic non-small cell lung carcinoma (NSCLC) samples.", "HU_ANGIOGENESIS_DN": "Down-regulated genes that separate angiogenic from non-angiogenic non-small cell lung carcinoma (NSCLC) samples.", "HUTTMANN_B_CLL_POOR_SURVIVAL_DN": "Down-regulated genes in B-CLL (B-cell chronic leukemia) patients expressing high levels of ZAP70 and CD38 [GeneID=7535;952], which are associated with poor survival.", "HUTTMANN_B_CLL_POOR_SURVIVAL_UP": "Up-regulated genes in B-CLL (B-cell chronic leukemia) patients expressing high levels of ZAP70 and CD38 [GeneID=7535;952], which are associated with poor survival.", "HU_GENOTOXIC_DAMAGE_24HR": "Genes most consistently regulated at 24 h by all six genotoxins tested: cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide [PubChem=2767;4156;5746;4666;3657;36462].", "HU_GENOTOXIC_DAMAGE_4HR": "Genes most consistently regulated at 4 h by all six genotoxins tested: cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide [PubChem=2767;4156;5746;4666;3657;36462].", "HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_24HR": "Genes discriminating between direct (cisplatin, MMS, mitomycin C [PubChem=2767;4156;5746]) and indirect (paclitaxel, hydroxyurea, etoposide [PubChem=4666;3657;36462]) acting genotoxins at 24 h time point.", "HWANG_PROSTATE_CANCER_MARKERS": "Proteins implicated in prostate carcinogenesis.", "HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_4HR": "Genes discriminating between direct (cisplatin, MMS, mitomycin C [PubChem=2767;4156;5746]) and indirect (paclitaxel, hydroxyurea, etoposide [PubChem=4666;3657;36462]) acting genotoxins at 4 h time point.", "IBRAHIM_NRF3_UP": "Transcripts up-regulated in HEK293T cells overexpressing FLAG-NRF3", "IBRAHIM_NRF1_DOWN": "Genes down-regulated in HEK293T cells overexpressing FLAG-NRF1", "IBRAHIM_NRF3_DOWN": "Genes down-regulated in HEK293T cells overexpressing FLAG-NRF3", "IBRAHIM_NRF1_UP": "Genes up-regulated in HEK293T cells overexpressing FLAG-NRF1", "IBRAHIM_NRF2_DOWN": "Genes down-regulated in HEK293T cells overexpressing FLAG-NRF2", "ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN": "Hepatic graft versus host disease (GVHD), day 35: genes down-regulated in allogeneic vs syngeneic bone marrow transplant.", "IBRAHIM_NRF2_UP": "Genes up-regulated in HEK293T cells overexpressing FLAG-NRF2", "ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_DN": "Hepatic graft versus host disease (GVHD), day 7: down-regulated in allogeneic vs syngeneic bone marrow transplant.", "ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP": "Hepatic graft versus host disease (GVHD), day 35: genes up-regulated in allogeneic vs syngeneic bone marrow transplant.", "ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP": "Hepatic graft versus host disease (GVHD), day 7: up-regulated in allogeneic vs syngeneic bone marrow transplant.", "IGARASHI_ATF4_TARGETS_UP": "", "IGARASHI_ATF4_TARGETS_DN": "Genes down-regulated in A549 cells (lung cancer) after knockdown of ATF4 [GeneID=468] by RNAi.", "IGLESIAS_E2F_TARGETS_DN": "Genes down-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type.", "IIZUKA_LIVER_CANCER_EARLY_RECURRENCE": "Genes down-regulated in hepatocellular carcinoma (HCC) tumors with higher risk of early intrahepatic recurrence. The single up-regulated gene (GenBank Accession=AC000063) has been excluded from the signature.", "IIZUKA_LIVER_CANCER_PROGRESSION_G1_G2_UP": "Genes up-regulated during transition from G1 (well differentiated tumor, infected with HCV) to G2 (moderately differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma.", "IIZUKA_LIVER_CANCER_PROGRESSION_G2_G3_DN": "Genes down-regulated during transition from G2 (moderately differentiated tumor, infected with HCV) to G3 (poorly differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma.", "IGLESIAS_E2F_TARGETS_UP": "Genes up-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type.", "IIZUKA_LIVER_CANCER_PROGRESSION_G1_G2_DN": "Genes down-regulated during transition from G1 (well differentiated tumor, infected with HCV) to G2 (moderately differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma.", "IIZUKA_LIVER_CANCER_PROGRESSION_G2_G3_UP": "Genes up-regulated during transition from G2 (moderately differentiated tumor, infected with HCV) to G3 (poorly differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma.", "IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_DN": "Genes down-regulated during transition from L0 (non-tumor, not infected with HCV) to L1 (non-tumor, infected with HCV) in the development of hepatocellular carcinoma.", "IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_UP": "Genes up-regulated during transition from L0 (non-tumor, not infected with HCV) to L1 (non-tumor, infected with HCV) in the development of hepatocellular carcinoma.", "IIZUKA_LIVER_CANCER_PROGRESSION_L1_G1_DN": "Genes down-regulated during transition from L1 (non-tumor, infected with HCV) to G1 (well differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma.", "IIZUKA_LIVER_CANCER_PROGRESSION_L1_G1_UP": "Genes up-regulated during transition from L1 (non-tumor, infected with HCV) to G1 (well differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma.", "IKEDA_MIR133_TARGETS_DN": "Genes down-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-133 microRNA.", "IM_SREBF1A_TARGETS": "Genes differentially expressed in liver tissue upon knockout of the 1a isoform of SREBF1 [GeneID=6720].", "IKEDA_MIR1_TARGETS_DN": "Genes down-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-1 microRNA.", "IKEDA_MIR30_TARGETS_DN": "Genes down-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-30 microRNA.", "IKEDA_MIR1_TARGETS_UP": "Genes up-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-1 microRNA.", "IKEDA_MIR133_TARGETS_UP": "Genes up-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-133 microRNA.", "IKEDA_MIR30_TARGETS_UP": "Genes up-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-30 microRNA.", "INAMURA_LUNG_CANCER_SCC_DN": "Down-regulated genes characteristic to the squamous cell carcinoma (SCC) type of non-small cell lung cancer (NSCLC).", "INAMURA_LUNG_CANCER_SCC_UP": "Up-regulated genes characteristic to the squamous cell carcinoma (SCC) type of non-small cell lung cancer (NSCLC).", "INAMURA_LUNG_CANCER_SCC_SUBTYPES_UP": "Up-regulated genes discriminating between two subtypes of squamous cell carcinoma (SCC) type of non-small cell lung cancer: SSC-A vs SSC-B.", "INGA_TP53_TARGETS": "Genes whose promoters contain TP53 [GeneID=7157] response elements.", "INGRAM_SHH_TARGETS_DN": "Genes down-regulated in 10T1/2 cells (multipotent mesoderma) by expression of SHH [GeneID=6469].", "IRITANI_MAD1_TARGETS_UP": "Genes up-regulated by overexpression of MAD1 [GeneID=4084] in primary thymocytes from RAG2 [GeneID=5897] knockout mice.", "INGRAM_SHH_TARGETS_UP": "Genes up-regulated in 10T1/2 cells (multipotent mesoderma) by expression of SHH [GeneID=6469].", "IRITANI_MAD1_TARGETS_DN": "Genes down-regulated by overexpression of MAD1 [GeneID=4084] in primary thymocytes from RAG2 [GeneID=5897] knockout mice.", "ISHIDA_E2F_TARGETS": "Genes up-regulated in MEF cells (embryonic fibroblast) after expression of E2F1 or E2F2 [GeneID=1869;1870].", "ISHIDA_TARGETS_OF_SYT_SSX_FUSIONS": "Genes down-regulated in synovial sarcoma samples with SYT-SSX fusions resulting from translocation of SS18 [GeneSymbol=SS18] to one of the SSX genes.", "ISHIKAWA_STING_SIGNALING": "Primary innate immune response genes induced in 293T cells (embryonic kidney) by overexpression of STING (TMEM173) [GeneID=340061].", "ITO_PTTG1_TARGETS_DN": "Genes down-regulated in HSA/c and KYSE140 cells (esophageal squamous cell carcinoma, ESCC) after knockdown of PTTG1 [GeneID=9232] by RNAi.", "ITO_PTTG1_TARGETS_UP": "Genes up-regulated in HSA/c and KYSE140 cells (esophageal squamous cell carcinoma, ESCC) after knockdown of PTTG1 [GeneID=9232] by RNAi.", "ISSAEVA_MLL2_TARGETS": "Genes down-regulated in HeLa cells upon knockdown of MLL2 [GeneID=8085] by RNAi.", "IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR": "Genes in the expression cluster 'Intermediate Progenitors Shared': up-regulated in hematopoietic intemediate progenitor cells from adult bone marrow and fetal liver.", "IVANOVA_HEMATOPOIESIS_MATURE_CELL": "Genes in the expression cluster 'MBC Shared': up-regulated in mature blood cell populations from adult bone marrow and fetal liver.", "IVANOV_MUTATED_IN_COLON_CANCER": "Genes mutated in colon cancer cell lines, identified using the GINI method described in the paper.", "IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR": "Genes in the expression cluster 'Late Progenitors Shared': up-regulated in hematopoietic late progenitor cells from adult bone marrow and fetal liver.", "IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR": "Genes in the expression cluster 'Early Progenitors Shared': up-regulated in hematopoietic progenitors from adult bone marrow and from fetal liver.", "IVANOVA_HEMATOPOIESIS_STEM_CELL_SHORT_TERM": "Genes in the expression cluster 'ST-HSC Shared': up-regulated in short term hematopoietic stem cells (ST-HSC) from adult bone marrow and fetal liver.", "IVANOVA_HEMATOPOIESIS_STEM_CELL": "Genes in the expression cluster 'HSC Shared': up-regulated in hematopoietic stem cells (HSC) from adult bone marrow and fetal liver.", "IVANOVSKA_MIR106B_TARGETS": "A consensus set of genes that were significantly down-regulated by MIR106B [GeneID=406900].", "IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM": "Genes in the expression cluster 'LT-HSC Shared': up-regulated in long term hematopoietic stem cells (LT-HSC) from adult bone marrow and fetal liver.", "IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR": "Genes in the expression cluster 'HSC and Progenitors Shared': up-regulated in hematopoietic stem cells (HSC) and progenitors from adult bone marrow and fetal liver.", "IWANAGA_CARCINOGENESIS_BY_KRAS_DN": "Cluster 4: genes down-regulated in lung tissue samples from mice with tumor-bearing genotypes (activated KRAS [GeneID=3845] alone or together with inactivated PTEN [GeneID=5728]).", "IWANAGA_E2F1_TARGETS_NOT_INDUCED_BY_SERUM": "Genes up-regulated in REF52 cells (embryonic fibroblast) by expression of E2F1 [GeneID=1869] that were not induced at all at 16 hr after serum stimulation.", "IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS": "Genes up-regulated in MCF-7 cells (breast cancer) in response to growth medium from L3T3-L1 cells (differentiated to pre-adipocytes).", "IWANAGA_E2F1_TARGETS_INDUCED_BY_SERUM": "Genes up-regulated in REF52 cells (embryonic fibroblast) by expression of E2F1 [GeneID=1869] that were also induced at 16 hr after serum stimulation.", "IWANAGA_CARCINOGENESIS_BY_KRAS_UP": "Cluster 3: genes up-regulated in lung tissue samples from mice with tumor-bearing genotypes (activated KRAS [GeneID=3845] alone or together with inactivated PTEN [GeneID=5728]).", "IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP": "Cluster 1: genes up-regulated in lung tissue samples from mice with oncogenic form of KRAS [GeneID=3845] and inactivated PTEN [GeneID=5728].", "IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN": "Cluster 2: genes down-regulated in lung tissue samples from mice with oncogenic form of KRAS [GeneID=3845] and inactivated PTEN [GeneID=5728].", "IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN": "Genes down-regulated in adipose tissue mesenchymal stem cells (ASC) vs bone marrow mesenchymal stem cells (rBMSC)", "IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP": "Genes up-regulated in adipose tissue mesenchymal stem cells (ASC) vs bone marrow mesenchymal stem cells (rBMSC)", "JAATINEN_HEMATOPOIETIC_STEM_CELL_DN": "Genes down-regulated in CD133+ [GeneID=8842] cells (hematopoietic stem cells, HSC) compared to the CD133- cells.", "JACKSON_DNMT1_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) upon Cre-lox knockout of DNMT1 [GeneID=1786].", "JAATINEN_HEMATOPOIETIC_STEM_CELL_UP": "Genes up-regulated in CD133+ [GeneID=8842] cells (hematopoietic stem cells, HSC) compared to the CD133- cells.", "JACKSON_DNMT1_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) upon Cre-lox knockout of DNMT1 [GeneID=1786].", "JAEGER_METASTASIS_UP": "Genes up-regulated in metastases from malignant melanoma compared to the primary tumors.", "JAERVINEN_AMPLIFIED_IN_LARYNGEAL_CANCER": "Genes whose expression was increased due to copy number gain in laryngeal cancer tumors (both in primary cultures and cell lines).", "JAEGER_METASTASIS_DN": "Genes down-regulated in metastases from malignant melanoma compared to the primary tumors.", "JAIN_NFKB_SIGNALING": "Genes abnormally regulated in response to CD40L and IL4 [GeneID=959;3565] stimulation of B lymphocytes from patients with a hypomorphic mutation of IKBKG [GeneID=8517].", "JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_UP": "Up-regulated genes distinguishing between breast cancer tumors with mutated BRCA1 [GeneID=672] from those with mutated BRCA2 [GeneID=675].", "JAZAG_TGFB1_SIGNALING_DN": "Genes down-regulated in PANC-1-puro cells (pancreatic cancer) stimulated by TGF1B [GeneID=7040] for 2 h.", "JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_DN": "Down-regulated genes distinguishing between breast cancer tumors with mutated BRCA1 [GeneID=672] from those with mutated BRCA2 [GeneID=675].", "JAZAG_TGFB1_SIGNALING_UP": "Genes up-regulated in PANC-1-puro cells (pancreatic cancer) stimulated by TGF1B [GeneID=7040] for 2 h.", "JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP": "Genes up-regulated in PANC-1-S4KD cells (pancreatic cancer; SMAD4 [GeneID=4089] knocked down by RNAi) after stimulation by TGF1B [GeneID=7040] for 2 h.", "JAZAG_TGFB1_SIGNALING_VIA_SMAD4_DN": "Genes down-regulated in PANC-1-S4KD cells (pancreatic cancer; SMAD4 [GeneID=4089] knocked down by RNAi) after stimulation by TGF1B [GeneID=7040] for 2 h.", "JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN": "Genes down-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]).", "JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP": "Genes up-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]).", "JEON_SMAD6_TARGETS_UP": "Genes up-regulated in H1299 cells (lung cancer) upon knockdown of SMAD6 [GeneID=4091] by RNAi.", "JEON_SMAD6_TARGETS_DN": "Genes down-regulated in H1299 cells (lung cancer) upon knockdown of SMAD6 [GeneID=4091] by RNAi.", "JEPSEN_SMRT_TARGETS": "Genes up-regulated in neural progenitor cells (NPC) isolated from E13 cortical tissue of SMRT [GeneID=9612] knockout mice.", "JIANG_AGING_CEREBRAL_CORTEX_UP": "Up-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls", "JIANG_AGING_CEREBRAL_CORTEX_DN": "Down-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls", "JIANG_AGING_HYPOTHALAMUS_DN": "Down-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls", "JIANG_AGING_HYPOTHALAMUS_UP": "Up-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls", "JIANG_CORE_DUPLICON_GENES": "Genes mapped to core duplicons - elements shared by a majority of segmental duplication blocks.", "JIANG_HYPOXIA_CANCER": "Genes up-regulated in 786-0 cells  (renal carcinoma, RCC) by hypoxia and in the absensce of VHL [GeneID=7428].", "JIANG_MELANOMA_TRM10_LAMINA_PROPRIA": "\u00a0", "JIANG_MELANOMA_TRM11_CD8": "\u00a0", "JIANG_HYPOXIA_VIA_VHL": "Genes up-regulated in 786-0 cells (renal carcinoma, RCC) by the loss of VHL [GeneID=7428] and in response to hypoxia.", "JIANG_MELANOMA_TRM2_CD8": "\u00a0", "JIANG_MELANOMA_TRM1_CD8": "\u00a0", "JIANG_HYPOXIA_NORMAL": "Genes up-regulated in RPTEC cells (normal kidney) by hypoxia.", "JIANG_MELANOMA_TRM4": "\u00a0", "JIANG_MELANOMA_TRM5_CD8": "\u00a0", "JIANG_MELANOMA_TRM3_CD8": "\u00a0", "JIANG_MELANOMA_TRM6_CD8": "\u00a0", "JIANG_TIP30_TARGETS_DN": "Down-regulated genes in HepG2 cells (liver cancer) overexpressing an oncogenic variant of tumor suppressor TIP30 [GeneID=10553] compared to its wild type form.", "JIANG_MELANOMA_TRM7_CD8": "\u00a0", "JIANG_MELANOMA_TRM_HIGH_SURVIVAL_22_GENE_SIGNATURE": "This gene set comprises a 22-gene signature derived from tissue-resident memory T cells (TRM) specifically associated with improved prognosis in melanoma patients. Enrichment of this signature in the tumor immune microenvironment (TIME) correlates with heightened immune activation, particularly involving T cells, NK cells, and M1 macrophages. High TRM infiltration is linked with longer overall survival and a more robust immune response. This signature enables stratification of melanoma patients into low- and high-risk categories, providing significant prognostic insights and aiding in the prediction of patient outcomes.", "JIANG_TIP30_TARGETS_UP": "Up-regulated genes in HepG2 cells (liver cancer) overexpressing an oncogenic variant of tumor suppressor TIP30 [GeneID=10553] compared to its wild type form.", "JIANG_MELANOMA_TRM8_CD4": "\u00a0", "JIANG_MELANOMA_TRM9_CD8": "\u00a0", "JIANG_VHL_TARGETS": "Genes up-regulated in 786-0 cells (renal carcinoma, RCC) upon expression of VHL [GeneID=7428] off a retroviral vector under normoxia (normal oxygen) condition.", "JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP": "Genes Upregulated in PBSHMS (RT4 blebbishield-to-immune cell fusion)", "JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_DN": "Genes Down-regulated in transformed spheres compared to blebbishields from RT4 cells", "JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP": "Genes up-regulated in transformed spheres compared to blebbishields from RT4 cells", "JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_DN": "Genes Downregulated in PBSHMS (RT4 blebbishield-to-immune cell fusion)", "JINESH_BLEBBISHIELD_VS_LIVE_CONTROL_DN": "Genes down-regulated in blebbishields compared to control RT4 live cells", "JISON_SICKLE_CELL_DISEASE_DN": "Genes down-regulated in peripheral blood mononuclear cells (PBMC) from sickle cell disease patients compared to those from healthy subjects.", "JI_CARCINOGENESIS_BY_KRAS_AND_STK11_DN": "Cluster B: genes down-regulated in primary lung tumors driven by KRAS [GeneID=3845] activation and loss of STK11 [GeneID=6794]; also up-regulated in human squamous cell carcinoma (SCC) vs adenocarcinoma subtype of NSCLC (non-small cell lung cancer).", "JI_CARCINOGENESIS_BY_KRAS_AND_STK11_UP": "Cluster A: genes up-regulated in primary lung tumors driven by KRAS [GeneID=3845] activation and loss of STK11 [GeneID=6794]; also up-regulated in human squamous cell carcinoma (SCC) vs adenocarcinoma subtype of NSCLC (non-small cell lung cancer).", "JINESH_BLEBBISHIELD_VS_LIVE_CONTROL_UP": "Genes up-regulated in blebbishields compared to control RT4 live cells", "JISON_SICKLE_CELL_DISEASE_UP": "Genes up-regulated in peripheral blood mononuclear cells (PBMC) from sickle cell disease patients compared to those from healthy subjects.", "JI_RESPONSE_TO_FSH_DN": "Down-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated", "JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_UP": "Genes up-regulated in early vs late brain tumors induced by retroviral delivery of PDGFB [GeneID=5155].", "JI_METASTASIS_REPRESSED_BY_STK11": "Adenocarcinoma metastatic program genes up-regulated in A549 and H2126 cells (lung cancer) lacking functional STK11 [GeneID=6794] but down-regulated by the normal gene.", "JI_RESPONSE_TO_FSH_UP": "Genes up-regulated in MCV152 cells (ovarian cancer) treated with follicle stimulating hormone (FSH).", "JOHANSSON_GLIOMAGENESIS_BY_PDGFB_DN": "Genes down-regulated in brain tumors induced by retroviral delivery of PDGFB [GeneID=5155].", "JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_DN": "Genes down-regulated in early vs late brain tumors induced by retroviral delivery of PDGFB [GeneID=5155].", "JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP": "Genes up-regulated in brain tumors induced by retroviral delivery of PDGFB [GeneID=5155].", "JOHNSTONE_PARVB_TARGETS_1_UP": "Genes up-regulated in MDA-MB-231 cells (breast cancer) upon overexpression of PARVB [GeneID=29780] under all three culture conditions.", "JOHNSTONE_PARVB_TARGETS_1_DN": "Genes down-regulated in MDA-MB-231 cells (breast cancer) upon overexpression of PARVB [GeneID=29780] under all three culture conditions.", "JOHNSTONE_PARVB_TARGETS_2_DN": "Genes down-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D collagen I and 3D Matrigel only.", "JONES_TCOF1_TARGETS": "Genes up-regulated in E8.5 embryos with heterozygous knockout of TCOF1 [GeneID=6949] compared to wild type.", "JU_AGING_TERC_TARGETS_UP": "Cytokines, growth factors, and secreted proteins that show increased expression on a protein array of samples from aged TERC [GeneID=7012] knockout mice.", "JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN": "Genes down-regulated in H460 cells (non-small cell lung carcinoma, NSCLC) after treatment with sodium butyrate [PubChem=5222465].", "JOHNSTONE_PARVB_TARGETS_2_UP": "Genes up-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D collagen I and 3D Matrigel only.", "JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_UP": "Genes up-regulated in H460 cells (non-small cell lung carcinoma, NSCLC) after treatment with sodium butyrate [PubChem=5222465].", "JOHNSTONE_PARVB_TARGETS_3_UP": "Genes up-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D Matrigel only.", "JOHNSTONE_PARVB_TARGETS_3_DN": "Genes down-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D Matrigel only.", "KAAB_FAILED_HEART_ATRIUM_UP": "Genes up-regulated in atria of failing hearts (DCM and ICM) compared to healthy controls.", "KAAB_FAILED_HEART_ATRIUM_DN": "Genes down-regulated in atria of failing hearts (DCM and ICM) compared to healthy controls.", "KAAB_FAILED_HEART_VENTRICLE_DN": "Genes down-regulated in the ventricles of failing hearts (DCM and ICM) compared to the healthy controls.", "KALMA_E2F1_TARGETS": "DNA replication genes up-regulated in a Rat-1a cell line (fibroblast) by expression of E2F1 [GeneID=1869].", "KAMIKUBO_MYELOID_MN1_NETWORK": "Network of differentially expressed myeloid genes centered around MN1 [GeneID=4330].", "KAMIKUBO_MYELOID_CEBPA_NETWORK": "Network of differentially expressed myeloid genes centered around CEBPA [GeneID=1050].", "KAAB_HEART_ATRIUM_VS_VENTRICLE_UP": "Genes up-regulated in the atria of healthy hearts, compared to venticles.", "KANG_AR_TARGETS_DN": "Genes down-regulated in osteoblasts from wild type male mice compared to those with AR [GeneID=367] knockout.", "KANG_AR_TARGETS_UP": "Genes up-regulated in osteoblasts from wild type male mice compared to those with AR [GeneID=367] knockout.", "KAMMINGA_SENESCENCE": "Genes down-regulated on serial passage of MEF cells (embryonic fibroblast).", "KAAB_HEART_ATRIUM_VS_VENTRICLE_DN": "Genes down-regulated in the ventricles of healthy hearts, compared to atria.", "KAMMINGA_EZH2_TARGETS": "Putative targets or partners of EZH2 [GeneID=2146] in hematopoietic stem cells.", "KANG_CISPLATIN_RESISTANCE_DN": "Genes down-regulated in gastric cancer cell lines resistant to cisplatin [PubChem=2767].", "KANG_CISPLATIN_RESISTANCE_UP": "Genes up-regulated in gastric cancer cell lines resistant to cisplatin [PubChem=2767].", "KANG_DOXORUBICIN_RESISTANCE_DN": "Genes down-regulated in gastric cancer cell lines: doxorubicin [PubChem=31703] resistant vs sensitive.", "KANG_FLUOROURACIL_RESISTANCE_UP": "Genes up-regulated in gastric cancer cell lines resistant to 5-fluorouracil [PubChem=3385].", "KANG_FLUOROURACIL_RESISTANCE_DN": "Genes down-regulated in gastric cancer cell lines resistant to 5-fluorouracil [PubChem=3385].", "KANG_DOXORUBICIN_RESISTANCE_UP": "Genes up-regulated in gastric cancer cell lines: doxorubicin [PubChem=31703] resistant vs sensitive.", "KANG_IMMORTALIZED_BY_TERT_UP": "Up-regulated genes in the signature of adipose stromal cells (ADSC) immortalized by forced expression of telomerase (TERT) [GeneID=7015].", "KANNAN_TP53_TARGETS_DN": "Primary down-regulated targets of TP53 [GeneID=7157] in the H1299 (lung cancer) cell line.", "KANG_IMMORTALIZED_BY_TERT_DN": "Down-regulated genes in the signature of adipose stromal cells (ADSC) immortalized by forced expression of telomerase (TERT) [GeneID=7015].", "KANG_GLIS3_TARGETS": "Genes downregulated in the postnatal day 3 pancreata with impaired function of GLIS3 [GeneID=169792].", "KAPOSI_LIVER_CANCER_MET_DN": "Selected down-regulated MET [GeneID=4233] target genes from a classifier of hepatocellular carcinoma (HCC) cases; associated with poor survival.", "KANNAN_TP53_TARGETS_UP": "Primary up-regulated targets of TP53 [GeneID=7157] in the H1299 (lung cancer) cell line.", "KAPOSI_LIVER_CANCER_MET_UP": "Selected up-regulated MET [GeneID=4233] target genes from a classifier of hepatocellular carcinoma (HCC) cases; associated with poor survival.", "KAN_RESPONSE_TO_ARSENIC_TRIOXIDE": "Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death.", "KARAKAS_TGFB1_SIGNALING": "Genes up-regulated by TGFB1 [GeneID=7040] in MCF10A cells (breast cancer): both wild-type and those lacking p21 [GeneID=1026].", "KARLSSON_TGFB1_TARGETS_DN": "Genes down-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046].", "KASLER_HDAC7_TARGETS_1_DN": "Genes down-regulated in DO11.10 cells (hybridoma) by expression of transciptionally activating form of HDAC7 [GeneID=51564] and up-regulated by its transcriptionally repressing form.", "KASLER_HDAC7_TARGETS_2_DN": "Genes down-regulated in DO11.10 cells (hybridoma) by expression of transciptionally activating and by transcriptionally repressive forms of HDAC7 [GeneID=51564].", "KASLER_HDAC7_TARGETS_1_UP": "Genes up-regulated in DO11.10 cells (hybridoma) by expression of transciptionally activating form of HDAC7 [GeneID=51564] and down-regulated by its transcriptionally repressing form.", "KARLSSON_TGFB1_TARGETS_UP": "Genes up-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046].", "KASLER_HDAC7_TARGETS_2_UP": "Genes up-regulated in DO11.10 cells (hybridoma) by expression of transciptionally activating and by transcriptionally repressive forms of HDAC7 [GeneID=51564].", "KAUFFMANN_DNA_REPAIR_GENES": "Genes involved in DNA repair, compiled manually by the authors.", "KAUFFMANN_MELANOMA_RELAPSE_DN": "DNA repair and replication genes down-regulated in melanoma patients who will relapse vs patients who will not.", "KATSANOU_ELAVL1_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) with ELAVL1 [GeneID=1994] knocked out.", "KATSANOU_ELAVL1_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) with ELAVL1 [GeneID=1994] knocked out.", "KAUFFMANN_DNA_REPLICATION_GENES": "Genes involved in DNA replication, compiled manually by the authors.", "KAYO_AGING_MUSCLE_DN": "Downregulated in the vastus lateralis muscle of aged vs young adult rhesus monkeys", "KAUFFMANN_MELANOMA_RELAPSE_UP": "DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not.", "KAYO_CALORIE_RESTRICTION_MUSCLE_UP": "Upregulated in the vastus lateralis muscle of middle aged rhesus monkeys subjected to caloric restriction since young adulthood vs age matched controls", "KAYO_CALORIE_RESTRICTION_MUSCLE_DN": "Downregulated in the vastus lateralis muscle of middle aged rhesus monkeys subjected to caloric restriction since young adulthood vs age matched controls", "KERLEY_RESPONSE_TO_CISPLATIN_DN": "Genes genes down-regulated in NT2/D1 cells (embryonal carcinoma) in response to treatment with cisplatin [PubChem=2767].", "KAYO_AGING_MUSCLE_UP": "Upregulated in the vastus lateralis muscle of aged vs young adult rhesus monkeys", "KENNY_CTNNB1_TARGETS_UP": "Genes up-regulated in HC11 cells (mammary epithelium) by expression of constantly active CTNNB1 [GeneID=1499].", "KENNY_CTNNB1_TARGETS_DN": "Genes down-regulated in HC11 cells (mammary epithelium) by expression of constantly active CTNNB1 [GeneID=1499].", "KERLEY_RESPONSE_TO_CISPLATIN_UP": "Genes genes up-regulated in NT2/D1 cells (embryonal carcinoma) in response to treatment with cisplatin [PubChem=2767].", "KHETCHOUMIAN_TRIM24_TARGETS_DN": "Retinoic acid-responsive genes down-regulated in hepatocellular carcinoma (HCC) samples of TRIM24 [GeneID=8805] knockout mice.", "KESHELAVA_MULTIPLE_DRUG_RESISTANCE": "Genes up-regulated in multiple drug resistant neuroblastoma cell lines.", "KHETCHOUMIAN_TRIM24_TARGETS_UP": "Retinoic acid-responsive genes up-regulated in hepatocellular carcinoma (HCC) samples of TRIM24 [GeneID=8805] knockout mice.", "KIM_ALL_DISORDERS_DURATION_CORR_UP": "Genes whose expression in brain significantly and positively correlated with the duration of all psychiatric disorders studied.", "KIM_ALL_DISORDERS_CALB1_CORR_DN": "Genes whose expression significantly and negatively correlated with the density of CALB1-positive [GeneID=793]  GABAergic interneurons in the BA9 brain region across all subjects with psychiatric disorders.", "KIM_ALL_DISORDERS_CALB1_CORR_UP": "Genes whose expression significantly and positively correlated with the density of CALB1-positive [GeneID=793]  GABAergic interneurons in the BA9 brain region across all subjects with psychiatric disorders.", "KIM_ALL_DISORDERS_DURATION_CORR_DN": "Genes whose expression in brain significantly and negatively correlated with the duration of all psychiatric disorders studied.", "KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_DN": "Genes whose expression was significantly and negatively correlated with the number of perineuronal oligodendrocytes in the layer III of BA9 brain region.", "KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN": "Genes whose expression significantly and negatively correlated with oligodendrocyte density in layer VI of BA9 brain region in patients with bipolar disorder.", "KIM_GASTRIC_CANCER_CHEMOSENSITIVITY": "Genes up-regulated in gastric cancer patients refractory to chemotherapy treatment with 5-fluorouracil and cisplatin [PubChem=3385;2767] compared to the sensitive state.", "KIM_GERMINAL_CENTER_T_HELPER_DN": "Genes down-regulated in germinal center T helper cells compared to other CD4+ [GeneID=920] T lymphocyte types.", "KIM_GLIS2_TARGETS_DN": "Partial list of genes down-regulated in the kidney of GLIS2 [GeneID=84662] knockout mice compared to the wild type.", "KIM_GERMINAL_CENTER_T_HELPER_UP": "Genes up-regulated in germinal center T helper cells compared to other CD4+ [GeneID=920] T lymphocyte types.", "KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP": "Genes whose expression was significantly and positively correlated with the number of perineuronal oligodendrocytes in the layer III of BA9 brain region.", "KIM_HYPOXIA": "Genes up-regulated in normal fibroblasts under hypoxia conditions.", "KIM_LIVER_CANCER_POOR_SURVIVAL_UP": "Genes over-expressed in hepatocellular carcinoma (HCC) with poor survival", "KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP": "Genes whose expression significantly and positively correlated with oligodendrocyte density in layer VI of BA9 brain region in patients with bipolar disorder.", "KIM_GLIS2_TARGETS_UP": "Partial list of genes up-regulated in the kidney of GLIS2 [GeneID=84662] knockout mice compared to the wild type.", "KIM_MYCL1_AMPLIFICATION_TARGETS_DN": "Genes negatively correlated with amplifications of MYCL1 [GeneID=4610] in SCLC (small cell lung cancer) cell lines.", "KIM_LIVER_CANCER_POOR_SURVIVAL_DN": "Genes under-expressed in hepatocellular carcinoma (HCC) with poor survival", "KIM_LRRC3B_TARGETS": "Immune response genes up-regulated in zenograft tumors formed by SNU-601 cells (gastric cancer) made to express LRRC3B [GeneID=116135].", "KIM_MYCL1_AMPLIFICATION_TARGETS_UP": "Genes positively correlated with amplifications of MYCL1 [GeneID=4610] in SCLC (small cell lung cancer) cell lines.", "KIM_MYCN_AMPLIFICATION_TARGETS_DN": "Genes negatively  correlated with amplifications of MYCN  [GeneID=4613] in the SCLC (small cell lung cancer) cell lines.", "KIM_MYCN_AMPLIFICATION_TARGETS_UP": "Genes positively  correlated with amplifications of MYCN  [GeneID=4613] in the SCLC (small cell lung cancer) cell lines.", "KIM_MYC_AMPLIFICATION_TARGETS_DN": "Genes negatively correlated with amplifications of MYC [GeneID=4609] in SCLC (small cell lung cancer) cell lines.", "KIM_PTEN_TARGETS_DN": "Genes down-regulated in HCT116 cells (colorectal carcinoma) upon knockout of PTEN [GeneID=5728].", "KIM_PTEN_TARGETS_UP": "Genes up-regulated in HCT116 cells (colorectal carcinoma) upon knockout of PTEN [GeneID=5728].", "KIM_RESPONSE_TO_TSA_AND_DECITABINE_DN": "Genes down-regulated in glioma cell lines treated with both decitabine [PubChem=451668] and TSA [PubChem=5562].", "KIM_MYC_AMPLIFICATION_TARGETS_UP": "Genes positively correlated with amplifications of MYC [GeneID=4609] in SCLC (small cell lung cancer) cell lines.", "KIM_TIAL1_TARGETS": "Top scoring genes whose transcripts bound TIAR1 [GeneID=7073] in extracts from RKO cells (colon cancer).", "KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP": "Genes up-regulated in glioma cell lines treated with both decitabine [PubChem=451668] and TSA [PubChem=5562].", "KIM_WT1_TARGETS_12HR_DN": "Genes down-regulated in UB27 cells (osteosarcoma) at 12 hr after inducing the expression of a mutated form of WT1 [GeneID=7490].", "KIM_WT1_TARGETS_12HR_UP": "Genes up-regulated in UB27 cells (osteosarcoma) at 12 hr after inducing the expression of a mutated form of WT1 [GeneID=7490].", "KIM_WT1_TARGETS_8HR_DN": "Genes down-regulated in UB27 cells (osteosarcoma) at 8 hr after inducing the expression of a mutant form of WT1 [GeneID=7490].", "KINNEY_DNMT1_METHYLATION_TARGETS": "Hypomethylated genes in prostate tissue from mice carrying hypomorphic alleles of DNMT1 [GeneID=1786].", "KIM_WT1_TARGETS_8HR_UP": "Genes up-regulated in UB27 cells (osteosarcoma) at 8 hr after inducing the expression of a mutant form of WT1 [GeneID=7490].", "KIM_WT1_TARGETS_UP": "Genes up-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490].", "KIM_WT1_TARGETS_DN": "Genes down-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490].", "KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN": "Genes down-regulated in AIDS-related primary effusion lymphoma (PEL) samples compared to other tumor subtypes and normal B lymphocytes.", "KLEIN_PRIMARY_EFFUSION_LYMPHOMA_UP": "Genes up-regulated in AIDS-related primary effusion lymphoma (PEL) samples compared to other tumor subtypes and normal B lymphocytes.", "KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN": "Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1  [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein.", "KLEIN_TARGETS_OF_BCR_ABL1_FUSION": "Genes changed in pre-B lymphoblastic leukemia cells with BCR-ABL1 fusion [GeneID=613] [GeneID=25] vs normal pre-B lymphocytes.", "KOBAYASHI_EGFR_SIGNALING_6HR_UP": "Genes up-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 6h.", "KOBAYASHI_EGFR_SIGNALING_24HR_UP": "Genes up-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h.", "KOBAYASHI_EGFR_SIGNALING_6HR_DN": "Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 6h.", "KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP": "Genes up-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1  [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein.", "KOBAYASHI_RESPONSE_TO_ROMIDEPSIN": "Genes up-regulated in MM-LH cells (malignant melanoma) after treatment with the HDAC inhibitor romidepsin (FK228) [PubChem=5352062].", "KOBAYASHI_EGFR_SIGNALING_24HR_DN": "Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h.", "KOHN_EMT_EPITHELIAL": "Epithelial phenotype associated genes from an Epithelial-Mesenchymal Transition (EMT) gene set allowing sample stratification into epithelial, mesenchymal, and epithelial-mesenchymal categories initially developed on the NCI-60 cell line collection.", "KOHN_EMT_MESENCHYMAL": "Mesenchymal phenotype associated genes from an Epithelial-Mesenchymal Transition (EMT) gene set allowing sample stratification into epithelial, mesenchymal, and epithelial-mesenchymal categories initially developed on the NCI-60 cell line collection.", "KOHOUTEK_CCNT1_TARGETS": "Genes down-regulated in E14 ES (embryonic stem) cells upon knockdown of CYCT1 [GeneID=904] by RNAi.", "KOHOUTEK_CCNT2_TARGETS": "Genes down-regulated in E14 ES (embryonic stem) cells upon knockdown of CYCT2 [GeneID=905] by RNAi.", "KOINUMA_COLON_CANCER_MSI_DN": "Genes down-regulated in colorectal carcinoma samples positive for MSI (microsatellite instability) compared to the MSI negative ones.", "KOINUMA_COLON_CANCER_MSI_UP": "Genes up-regulated in colorectal carcinoma samples positive for MSI (microsatellite instability) compared to the MSI negative ones.", "KOMMAGANI_TP63_GAMMA_TARGETS": "Genes changed in H1299 cells (non-small cell lung cancer, NSCLC) transiently transfected to express the TP63 [GeneID=8626] gamma splice variant.", "KONDO_COLON_CANCER_HCP_WITH_H3K27ME1": "Genes with high levels of histone H3 monomethylation mark at K27 (H3K27me1) in SW48 cells (colon cancer) by ChIP-chip assay on a 12K CpG array (CpG promoters only, HCP=high-CpG-density promoters).", "KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_DN": "Genes down-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation.", "KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN": "Genes down-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation.", "KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP": "Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation.", "KONDO_COLON_CANCER_HCP_WITH_H3K27ME3": "Genes with high histone H3 tri-methylation mark at K27 (H3K27me3) in SW48 cells (colon cancer), by ChIP-chip assay on a 12K CpG array (high-CpG-density promoters, HCP).", "KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP": "Genes up-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation.", "KONDO_HYPOXIA": "Genes up-regulated in HSC-2/8 cells (chondrosarcoma) under hypoxic conditions.", "KONDO_EZH2_TARGETS": "Genes up-regulated in PC3 cells (prostate cancer) after EZH2 [GeneID=2146] knockdown by RNAi.", "KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3": "Genes with promoters occupied by SMAD2 or SMAD3 [GeneID=4087] [GeneID=4088] in HaCaT cells (keratinocyte) according to a ChIP-chip analysis.", "KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3": "Genes with high histone H3 trimethylation mark at K27 (H3K27me3) in PC3 cells (prostate cancer) by ChIP-chip assay on a 12K CpG array (high-CpG-density promoters, HCP).", "KONG_E2F3_TARGETS": "Genes up-regulated in MEF cells (embryonic fibroblasts) at 16 hr after serum stimulation and knockdown of E2F3 [GeneID=1871] by RNAi.", "KORKOLA_CHORIOCARCINOMA_UP": "Genes from the 12p region that were up-regulated in choriocarcinoma cells compared to normal testis.", "KORKOLA_CHORIOCARCINOMA": "Genes predicting the choriocarcinoma (CC) of nonseminomatous male germ cell tumors (NSGCT).", "KORKOLA_CHORIOCARCINOMA_DN": "Genes from the 12p region that were down-regulated in choriocarcinoma cells compared to normal testis.", "KONG_E2F1_TARGETS": "Genes up-regulated in MEF cells (embryonic fibroblast) at 16 h after serum stimulation and knockdown of E2F1 [GeneID=1869] by RNAi.", "KONDO_PROSTATE_CANCER_WITH_H3K27ME3": "Top 200 genes with high histone H3 trimethylation mark at K27 (H3K27me3) in PC3 cells (prostate cancer), by ChIP-chip assay on an 88K microarray (all promoters).", "KORKOLA_EMBRYONAL_CARCINOMA": "Genes predicting the embryonic carcinoma (EC) subtype of nonseminomatous male germ cell tumors (NSGCT).", "KORKOLA_CORRELATED_WITH_POU5F1": "Genes whose expression pattern in adult male germ cell tumors (GCT) correlates with POU5F1 [GeneID=5460].", "KORKOLA_EMBRYONAL_CARCINOMA_DN": "Genes from the 12p region that were down-regulated in embryonic carcinoma tumors compared to normal tissue.", "KORKOLA_EMBRYONAL_CARCINOMA_UP": "Genes from the 12p region that were up-regulated in embryonic carcinoma tumors compared to normal testis.", "KORKOLA_EMBRYONIC_CARCINOMA_VS_SEMINOMA_DN": "Top 25 most highly expressed genes in seminoma relative to embryonic carcinoma tumors.", "KORKOLA_EMBRYONIC_CARCINOMA_VS_SEMINOMA_UP": "Top 25 most highly expressed genes in embryonic carcinoma relative to seminoma tumors.", "KORKOLA_SEMINOMA_DN": "Genes from the 12p region that were down-regulated in seminoma tumors compared to normal testis.", "KORKOLA_TERATOMA": "Genes predicting the teratoma (T) subtype of nonseminomatous male germ cell tumors (NSGCT).", "KORKOLA_SEMINOMA_UP": "Genes from the 12p region that were up-regulated in seminoma tumors compared to normal testis.", "KORKOLA_YOLK_SAC_TUMOR": "Genes predicting the yolk sac tumor (YS) subtype of nonseminomatous male germ cell tumors (NSGCT).", "KORKOLA_TERATOMA_UP": "Genes from the 12p region that up-regulated in teratoma cells compared to normal testis.", "KORKOLA_YOLK_SAC_TUMOR_UP": "Genes from the 12p region that were up-regulated in yolk sac tumor cells compared to normal testis.", "KRASNOSELSKAYA_ILF3_TARGETS_UP": "Up-regulated in GHOST(3)CXCR4 cells (osteosarcoma) upon ectopic expression of ILF3 [GeneID=3609].", "KRASNOSELSKAYA_ILF3_TARGETS_DN": "Down-regulated in GHOST(3)CXCR4 cells (osteosarcoma) upon ectopic expression of ILF3 [GeneID=3609].", "KREPPEL_CD99_TARGETS_DN": "Genes down-regulated in ESFT cells (Ewing's sarcoma family of tumors) after knockdown of CD99 [GeneID=4267] by RNAi.", "KOYAMA_SEMA3B_TARGETS_UP": "Genes up-regulated in NCI-H1299 cells (large cell neuroendocrine carcinoma) stably expressing SEMA3B [GeneID=7869].", "KOYAMA_SEMA3B_TARGETS_DN": "Genes down-regulated in NCI-H1299 cells (large cell neuroendocrine carcinoma) stably expressing SEMA3B [GeneID=7869].", "KRIEG_HYPOXIA_VIA_KDM3A": "Genes dependent on KDM3A [GeneID=55818] for hypoxic induction in RCC4 cells (renal carcinoma) expressing VHL [GeneID=7428].", "KRIGE_AMINO_ACID_DEPRIVATION": "The 'amino acid deprivation response' (AADR): genes up-regulated in HL-60 cells (acute promyelocytic leukemia, APL) after amino acid deprivation or treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703].", "KRIEG_KDM3A_TARGETS_NOT_HYPOXIA": "Genes not induced under hypoxia, but dependent on KDM3A [GeneID=55818] for hypoxic expression in RCC4 cells (renal carcinoma) expressing VHL [GeneID=7428].", "KRIEG_HYPOXIA_NOT_VIA_KDM3A": "Genes induced under hypoxia independently of KDM3A [GeneID=55818] in RCC4 cells (renal carcinoma) expressing VHL [GeneID=7428].", "KRISHNAN_FURIN_TARGETS_DN": "Genes down-regulated in naive T lymphocytes lacking FURIN [GeneID=5045]: Cre-Lox knockout of FURIN in CD4+ [GeneID=920] cells.", "KUMAMOTO_RESPONSE_TO_NUTLIN_3A_DN": "Genes down-regulated in response to nutlin-3a [PubChem=216345], an inhibitor of MDM2 [GeneID=4193],  in skin fibroblast cultures after knockdown of TP53 [GeneID=7157] by RNAi.", "KRISHNAN_FURIN_TARGETS_UP": "Genes up-regulated in naive T lymphocytes lacking FURIN [GeneID=5045]: Cre-Lox knockout of FURIN in CD4+ [GeneID=920] cells.", "KUMAMOTO_RESPONSE_TO_NUTLIN_3A_UP": "Genes up-regulated in response to nutlin-3a [PubChem=216345], an inhibitor of MDM2 [GeneID=4193],  in skin fibroblast cultures after knockdown of TP53 [GeneID=7157] by RNAi.", "KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN": "Genes down-regulated in HL-60 cells (acute promyelocytic leukemia, APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h.", "KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN": "Genes down-regulated in HL-60 cells (acute promyelocytic leukemia, APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 6 h.", "KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP": "Genes up-regulated in HL-60 cells (acute promyelocytic leukemia, APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 6 h.", "KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP": "Genes up-regulated in HL-60 cells (acute promyelocytic leukemia, APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h.", "KUMAR_AUTOPHAGY_NETWORK": "Genes defining the Mycobacterium tuberculosis strain-independent regulatory axis of the host macrophage cells.", "KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES": "Genes indentified by RNAi screen as regulating infection of THP-1 cells (macrophage) with Mycobacterium tuberculosis.", "KUNINGER_IGF1_VS_PDGFB_TARGETS_UP": "Genes up-regulated in C2AS12 cells (myoblast) by IGF1 [GeneID=3479] vs PDGFB [GeneID=5155].", "KUNINGER_IGF1_VS_PDGFB_TARGETS_DN": "Genes down-regulated in C2AS12 cells (myoblast) by IGF1 [GeneID=3479] vs PDGFB [GeneID=5155].", "KUROKAWA_LIVER_CANCER_EARLY_RECURRENCE_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) with early recurrence.", "KUMAR_TARGETS_OF_MLL_AF9_FUSION": "Myeloid leukemia model in mice with germ-line MLL-AF9 fusion knock-in [GeneID=4297;4300]: genes changed in comparison among the leukemic, preleukemic and wild-type animals.", "KUROKAWA_LIVER_CANCER_EARLY_RECURRENCE_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) with early recurrence.", "KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS_AND_CYCLIC_RGD": "Inflammatory cytokines and their receptors moduated in brain tumors in response to treatment with cyclic RGD peptide prior to the oncocytic virus therapy.", "KUWANO_RNA_STABILIZED_BY_NO": "Transcripts stabilized by NO [PubChem=145068] identified as up-regulated by NO [PubChem=145068] in the presence of actinomycin D [PubChemiD=2019] in IMR-90 and NIH 3T3 cells (fibroblast).", "KUUSELO_PANCREATIC_CANCER_19Q13_AMPLIFICATION": "List of genes in the 19q13 amplicon region based on a copy number alterations study of a panel of 16 pancreatic cancer cell lines and 31 primary tumors.", "KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS": "Inflammatory cytokines and their receptors modulated in brain tumors after treatment with an oncocytic virus, a potential anticancer therapy.", "KYNG_DNA_DAMAGE_BY_4NQO_OR_GAMMA_RADIATION": "Genes responding to 4NQO treatment and gamma irradiation.", "KYNG_DNA_DAMAGE_BY_4NQO_OR_UV": "4NQO treatment and UV irradiation responding genes.", "KYNG_DNA_DAMAGE_BY_4NQO": "Genes specifically responding to 4NQO treatment of primary fibroblasts.", "KYNG_DNA_DAMAGE_BY_UV": "UV only responding genes in primary fibroblasts from young donors.", "KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION": "Gamma and UV responding genes.", "KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION": "Genes specifically responding to gamma radiation.", "KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_OLD": "Human environmental etress response genes not changed in primary fibroblasts from old donors in response to 4NQO treatment.", "KYNG_ENVIRONMENTAL_STRESS_RESPONSE_DN": "All common down-regulated stress response genes (Human Environmental Stress Response, H-ESR).", "KYNG_DNA_DAMAGE_UP": "Genes with GO annotation and up-regulated after DNA damage in cell lines from young donors.", "KYNG_DNA_DAMAGE_DN": "Genes with GO annotation and down-regulated after DNA damage in cell lines from young donors.", "KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_WS": "Human environmental stress response genes not changed in primary fibroblasts from Wilmor syndrom (WS) patients in response to 4NQO treatment.", "KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_WS": "Human environmental stress response genes not changed in primary fibroblasts from Werner syndrom (WS) patients in response to gamma radiation.", "KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_OLD": "Human environmental stress response (H-ESR) genes not changed in primary fibroblasts from old donors in response to gamma radiation.", "KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_UV_IN_WS": "Human environmental stress response genes not changed in primary fibroblasts from patients with Warner syndrom (WS) .", "KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP": "All common  up-regulated stress response genes (Human Environmental Stress Response, H-ESR).", "KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_UV_IN_OLD": "Human environmental stress response genes not changed in primary fibroblasts from old donors in response to UV radiation.", "KYNG_NORMAL_AGING_UP": "Genes distinctly up-regulated in primary fibroblast cultures from normal old donors compared to those from normal young donors.", "KYNG_NORMAL_AGING_DN": "Genes distinctly down-regulated in primary fibroblast cultures from normal old donors compared to those from normal young donors.", "KYNG_RESPONSE_TO_H2O2_VIA_ERCC6": "Genes down-regulated in CS-B cells (Cockayne syndrome fibroblast, CS) with defficient ERCC6 [GeneID=2074] in response to hydrogen peroxide [PubChem=784].", "KYNG_RESPONSE_TO_H2O2": "Genes up-regulated in response to hydrogen peroxide [PubChem=784] in CS-B cells (Cockayne syndrome fibroblast, CS) expressing ERCC6 [GeneID=2074] off a plasmid vector.", "KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_DN": "Genes down-regulated in response to hydorgen peroxyde [PubChem=784] in CS-B cells (Cockaine syndrome fibroblast, CS) with defficient ERCC6 [GeneID=2074].", "KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP": "Genes up-regulated in response to hydorgen peroxyde [PubChem=784] in CS-B cells (Cockaine syndrome fibroblast, CS) with defficient ERCC6 [GeneID=2074].", "KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP": "Genes up-regulated similarly  in primary fibroblast cultures from Werner syndrom patients and normal old donors compared to those from normal young donors.", "KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN": "Genes down-regulated similarly  in primary fibroblast cultures from Werner syndrom patients and normal old donors compared to those from normal young donors.", "KYNG_WERNER_SYNDROM_UP": "Genes distinctly up-regulated in primary fibroblast cultures from Werner syndrom patients compared to those from normal young donors.", "KYNG_WERNER_SYNDROM_DN": "Genes distinctly down-regulated in primary fibroblast cultures from Werner syndrom patients compared to those from normal young donors.", "LAIHO_COLORECTAL_CANCER_SERRATED_DN": "Genes down-regulated in serrated vs conventional colorectal carcinoma (CRC) samples.", "LANDEMAINE_LUNG_METASTASIS": "Genes associated with metastasis of breast cancer in the lung compared to the non-lung metastasis.", "LAMB_CCND1_TARGETS": "The cyclin D1 signature: genes whose expression correlated with the levels of CCND1 [GeneID=595].", "LAIHO_COLORECTAL_CANCER_SERRATED_UP": "Genes up-regulated in serrated vs conventional colorectal carcinoma (CRC) samples.", "LANDIS_BREAST_CANCER_PROGRESSION_UP": "Genes up-regulated in preneoplastic mammary tissues and whose expression is maintained in tumors.", "LANDIS_BREAST_CANCER_PROGRESSION_DN": "Genes down-regulated in preneoplastic mammary tissues and whose expression is maintained in tumors.", "LANDIS_ERBB2_BREAST_PRENEOPLASTIC_DN": "Down-regulated genes from top 82 genes out of the 324-gene signature identified in the pre-neoplastic tissue adjacent to the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064].", "LANDIS_ERBB2_BREAST_PRENEOPLASTIC_UP": "Up-regulated genes from top 82 genes out of the 324-gene signature identified in the pre-neoplastic tissue adjacent to the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064].", "LANDIS_ERBB2_BREAST_TUMORS_65_DN": "Down-regulated genes from the 65 most significantly changed (p[GeneID=2064].", "LANG_MYB_FAMILY_TARGETS": "Myb family target genes.", "LANDIS_ERBB2_BREAST_TUMORS_65_UP": "Up-regulated genes from the 65 most significantly changed (p[GeneID=2064].", "LANDIS_ERBB2_BREAST_TUMORS_324_DN": "Down-regulated genes from the 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064].", "LANDIS_ERBB2_BREAST_TUMORS_324_UP": "Up-regulated genes from the 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064].", "LASTOWSKA_COAMPLIFIED_WITH_MYCN": "Genes co-amplified within MYCN [GeneID=4613] in primary neuroblastoma tumors.", "LAU_APOPTOSIS_CDKN2A_DN": "Genes down-regulated by UV-irradiation in cervical cancer cells after knockdown of CDKN2A [GeneID=1029].", "LAU_APOPTOSIS_CDKN2A_UP": "Genes up-regulated by UV-irradiation in cervical cancer cells after knockdown of CDKN2A [GeneID=1029].", "LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_UP": "Genes with copy number gains in primary neuroblastoma tumors.", "LA_MEN1_TARGETS": "Genes up-regulated in cells expressing MEN1 [GeneID=4221].", "LEE_AGING_MUSCLE_DN": "Downregulated in the gastrocnemius muscle of aged adult mice (30-month) vs young adult (5-month)", "LEE_AGING_CEREBELLUM_UP": "Upregulated in the cerebellum of aged adult mice (30-month) vs young adult (5-month)", "LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN": "Genes with copy number losses in primary neuroblastoma tumors.", "LEE_AGING_NEOCORTEX_DN": "Downregulated in the neocortex of aged adult mice (30-month) vs young adult (5-month)", "LEE_AGING_CEREBELLUM_DN": "Downregulated in the cerebellum of aged adult mice (30-month) vs young adult (5-month)", "LEE_AGING_MUSCLE_UP": "Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs young adult (5-month)", "LEE_AGING_NEOCORTEX_UP": "Upregulated in the neocortex of aged adult mice (30-month) vs young adult (5-month)", "LEE_CALORIE_RESTRICTION_MUSCLE_DN": "Down-regulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction diet since young adulthood.", "LEE_CALORIE_RESTRICTION_NEOCORTEX_DN": "Down-regulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood.", "LEE_CALORIE_RESTRICTION_MUSCLE_UP": "Up-regulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction diet since young adulthood.", "LEE_CALORIE_RESTRICTION_NEOCORTEX_UP": "Up-regulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood.", "LEE_EARLY_T_LYMPHOCYTE_DN": "Genes down-regulated at early stages of progenitor T lymphocyte maturation compared to the late stages.", "LEE_BMP2_TARGETS_DN": "Genes down-regulated in uterus upon knockout of BMP2 [GeneID=650].", "LEE_BMP2_TARGETS_UP": "Genes up-regulated in uterus upon knockout of BMP2 [GeneID=650].", "LEE_DOUBLE_POLAR_THYMOCYTE": "Genes enriched in the double polar (DP) thymocyte compared to all other T lymphocyte differentiation stages.", "LEE_DIFFERENTIATING_T_LYMPHOCYTE": "Genes enriched at every T lymphocyte differentiation stage compared to the early passage fetal thymic stromal cultures (TSC).", "LEE_EARLY_T_LYMPHOCYTE_UP": "Genes up-regulated at early stages of progenitor T lymphocyte maturation compared to the late stages.", "LEE_INTRATHYMIC_T_PROGENITOR": "Genes enriched in the intrathymic T progenitor (ITTP) cells compared to all other T lymphocyte differentiation stages.", "LEE_LIVER_CANCER_ACOX1_UP": "Genes up-regulated in hepatocellular carcinoma of ACOX1 [GeneID=51] knockout mice.", "LEE_LIVER_CANCER_ACOX1_DN": "Genes down-regulated in hepatocellular carcinoma of ACOX1 [GeneID=51] knockout mice.", "LEE_LIVER_CANCER_CIPROFIBRATE_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) induced by ciprofibrate [PubChem=2763].", "LEE_LIVER_CANCER_DENA_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) induced by diethylnitrosamine (DENA) [PubChem=5921].", "LEE_LIVER_CANCER_HEPATOBLAST": "Fig.5, Supplementary Fig.2 Genes overexpressed in human hepatocellular carcinoma with hepatoblast property", "LEE_LIVER_CANCER_DENA_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) induced by diethylnitrosamine (DENA) [PubChem=5921].", "LEE_LIVER_CANCER_E2F1_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) induced by overexpression of E2F1 [GeneID=1869].", "LEE_LIVER_CANCER_CIPROFIBRATE_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) induced by ciprofibrate [PubChem=2763].", "LEE_LIVER_CANCER_E2F1_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) induced by overexpression of E2F1 [GeneID=1869].", "LEE_LIVER_CANCER_MYC_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) induced by overexpression of MYC [GeneID=4609].", "LEE_LIVER_CANCER_MYC_E2F1_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) from MYC and E2F1 [GeneID=4609;1869] double transgenic mice.", "LEE_LIVER_CANCER_MYC_E2F1_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) from MYC and E2F1 [GeneID=4609;1869] double transgenic mice.", "LEE_LIVER_CANCER_MYC_TGFA_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) tissue of MYC and TGFA [GeneID=4609;7039] double transgenic mice.", "LEE_LIVER_CANCER_MYC_TGFA_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) tissue of MYC and TGFA [GeneID=4609;7039] double transgenic mice.", "LEE_LIVER_CANCER_MYC_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) induced by overexpression of MYC [GeneID=4609].", "LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP": "Up-regulated genes displaying alternative splicing in MDA-MB-435 cells (breast cancer) whose metastatic potential has been reduced by expression of NME1 [GeneID=4830].", "LEE_METASTASIS_AND_RNA_PROCESSING_UP": "Components of RNA post-transcriptional modification machinery up-regulated in MDA-MB-435 cells (breast cancer) whose metastatic potential has been reduced by expression of NME1 [GeneID=4830].", "LEE_LIVER_CANCER_SURVIVAL_DN": "Genes highly expressed in hepatocellular carcinoma with poor survival.", "LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_DN": "Down-regulated genes displaying alternative splicing in MDA-MB-435 cells (breast cancer) whose metastatic potential has been reduced by expression of NME1 [GeneID=4830].", "LEE_LIVER_CANCER_SURVIVAL_UP": "Genes highly expressed in hepatocellular carcinoma with good survival.", "LEE_NAIVE_T_LYMPHOCYTE": "Genes enriched in the naive circulating T lymphocytes compared to the earlier differentiation stages.", "LEE_NEURAL_CREST_STEM_CELL_DN": "Genes down-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087].", "LEE_RECENT_THYMIC_EMIGRANT": "Candidate genes specific for recent thymic emigrants (RTEs).", "LEE_SP4_THYMOCYTE": "Genes enriched in the single positive 4 (SP4) thymocytes compared to all other T lymphocyte differentiation stages.", "LEE_NEURAL_CREST_STEM_CELL_UP": "Genes up-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087].", "LEIN_ASTROCYTE_MARKERS": "Genes enriched in astrocytes in the adult mouse brain identified through correlation-based searches seeded with the astrocyte cell-type specific gene expression patterns.", "LEE_TARGETS_OF_PTCH1_AND_SUFU_DN": "Genes down-regulated in medulloblastoma tumors from animals with  inactivating mutations of one copy of PTCH1 or SUFU [GeneID=5727;51684] in conjunction with TP53 [GeneID=7157] loss.", "LEE_TARGETS_OF_PTCH1_AND_SUFU_UP": "Genes up-regulated in medulloblastoma tumors from animals with  inactivating mutations of one copy of PTCH1 or SUFU [GeneID=5727;51684] in conjunction with TP53 [GeneID=7157] loss.", "LEIN_CEREBELLUM_MARKERS": "Top 100 ranked genes most specific to the cerebellum region of adult mouse brain.", "LEIN_LOCALIZED_TO_DISTAL_AND_PROXIMAL_DENDRITES": "Transcripts showing subcellular localization to both distal and proximal dendrites in the adult mouse brain.", "LEIN_CHOROID_PLEXUS_MARKERS": "Genes enriched in choroid plexus cells in the brain identified through correlation-based searches seeded with the choroid plexus cell-type specific gene expression patterns.", "LEIN_LOCALIZED_TO_PROXIMAL_DENDRITES": "Transcripts showing subcellular localization only to proximal dendrites in the adult mouse brain.", "LEIN_MIDBRAIN_MARKERS": "Top 100 ranked genes most specific to midbrain region of adult mouse brain.", "LEIN_NEURON_MARKERS": "Genes enriched in neurons in the adult mouse brain identified through correlation-based searches seeded with neuron cell-type specific gene expression patterns.", "LEIN_MEDULLA_MARKERS": "Top 100 ranked genes most specific to  medulla (myelencephalon) hindbrain region of adult mouse brain.", "LEIN_OLIGODENDROCYTE_MARKERS": "Genes enriched in oligodendrocytes in the adult mouse brain identified through correlation-based searches seeded with the oligodendrocyte cell-type specific gene expression patterns.", "LEI_HOXC8_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblasts) by overexpression of HOXC8 [GeneID=3224].", "LEI_HOXC8_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblasts) by overexpression of HOXC8 [GeneID=3224].", "LEIN_PONS_MARKERS": "Top 100 ranked genes most specific to  pons region (P) of the adult mouse brain.", "LENAOUR_DENDRITIC_CELL_MATURATION_UP": "Genes up-regulated during in vitro maturation of CD14+ [GeneID=929] monocytes (day 0) into immature (day 7) and mature dendritic cells (day 14).", "LENAOUR_DENDRITIC_CELL_MATURATION_DN": "Genes down-regulated during in vitro maturation of CD14+ [GeneID=929] monocytes (day 0) into immature (day 7) and mature dendritic cells (day 14).", "LEI_MYB_TARGETS": "Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602].", "LE_NEURONAL_DIFFERENTIATION_DN": "Genes down-regulated during neuronal differentiation of SH-SY5Y cells (neuroblastoma) in response to stimulation by tretinoin (all-trans retinoic acid, ATRA) [PubChem=444795] and BDNF [GeneID=627].", "LE_EGR2_TARGETS_DN": "Genes down-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [GeneID=1959].", "LEONARD_HYPOXIA": "Genes up-regulated in HK-2 cells kidney tubular epithelium) under hypoxia and down-regulated on re-oxygenation.", "LE_EGR2_TARGETS_UP": "Genes up-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [GeneID=1959].", "LE_NEURONAL_DIFFERENTIATION_UP": "Genes up-regulated during neuronal differentiation of SH-SY5Y cells (neuroblastoma) in response to stimulation by tretinoin (all-trans retinoic acid, ATRA) [PubChem=444795] and BDNF [GeneID=627].", "LE_SKI_TARGETS_DN": "Selected genes implicated in metastasis and epithelial-to-mesenchymal transition (EMT) which were down-regulated in MDA-MB-231 cells (breast cancer) upon knockdown of SKI [GeneID=6497] by RNAi.", "LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_QTL": "Genes changed in LSK cells (bone marrow) as a function of a QTL for the size of hematopoietic stem cell (HSC) population: comparison of reciprocal congenic strains D.B. Chr3 (DB), B.D. Chr3 (BD) and the parental strains B6 and D2.", "LE_SKI_TARGETS_UP": "Selected genes implicated in metastasis and epithelial-to-mesenchymal transition (EMT) which were up-regulated in MDA-MB-231 cells (breast cancer) upon knockdown of SKI [GeneID=6497] by RNAi.", "LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_DN": "Genes down-regulated in LSK cells (bone marrow) as a function of a QTL for the size of hematopoietic stem cell (HSC) population: comparison of congenic B.D. chr3 (BD, large HSC size) vs parental B6 strain (tiny HSC size).", "LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_UP": "Genes up-regulated in LSK cells (bone marrow) as a function of a QTL for the size of hematopoietic stem cell (HSC) population: comparison of congenic B.D. chr3 (BD, large HSC size) vs parental B6 strain (tiny HSC size).", "LIANG_SILENCED_BY_METHYLATION_DN": "Genes down-regulated in LD419 cells (fibroblast) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].", "LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_SMALL_VS_HUGE_DN": "Genes down-regulated in LSK cells (bone marrow) as a function of a QTL for the size of hematopoietic stem cell (HSC) population: comparison of congenic D.B. Chr 3 (DB, small HSC population) vs parental D2 strain (huge HSC population).", "LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_SMALL_VS_HUGE_UP": "Genes up-regulated in LSK cells (bone marrow) as a function of a QTL for the size of hematopoietic stem cell (HSC) population: comparison of congenic D.B. Chr 3 (DB, small HSC population) vs parental D2 strain (huge HSC population).", "LIANG_SILENCED_BY_METHYLATION_UP": "Genes up-regulated in LD419 cells (fibroblast) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].", "LIANG_SILENCED_BY_METHYLATION_2": "Genes up-regulated in T24 cells (bladder carcinoma) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].", "LIAN_LIPA_TARGETS_3M": "Genes up-regulated at 3 months of age in lungs from LIPA [GeneID=3988] knockout mice, which display pulmonary pathology.", "LIAN_LIPA_TARGETS_6M": "Genes up-regulated at 6 months of age in lungs from LIPA [GeneID=3988] knockout mice, which display pulmonary pathology.", "LIAN_NEUTROPHIL_GRANULE_CONSTITUENTS": "Granule constituents expressed during mouse promyelocytic cell line differentiation to neutrophils.", "LIAO_HAVE_SOX4_BINDING_SITES": "Genes up-regulated in the samples with intrahepatic metastatic hepatocellular carcinoma (HCC) vs primary HCC that also have putative binding sites for SOX4 [GeneID=6659].", "LIEN_BREAST_CARCINOMA_METAPLASTIC": "Genes up-regulated in metaplastic carcinoma of the breast (MCB) subclass 2 compared to the MCB subclass 1.", "LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_DN": "Genes down-regulated between two breast carcinoma subtypes: metaplastic (MCB) and ductal (DCB).", "LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UP": "Genes up-regulated between two breast carcinoma subtypes: metaplastic (MCB) and ductal (DCB).", "LIM_MAMMARY_LUMINAL_MATURE_DN": "Genes consistently down-regulated in mature mammary luminal cells both in mouse and human species.", "LIM_MAMMARY_LUMINAL_PROGENITOR_DN": "Genes consistently down-regulated in mammary luminal progenitor cells both in mouse and human species.", "LIAO_METASTASIS": "Genes up-regulated in the samples with intrahepatic metastatic hepatocellular carcinoma (HCC) vs primary HCC.", "LIM_MAMMARY_LUMINAL_MATURE_UP": "Genes consistently up-regulated in mature mammary luminal cells both in mouse and human species.", "LIM_MAMMARY_LUMINAL_PROGENITOR_UP": "Genes consistently up-regulated in mammary luminal progenitor cells both in mouse and human species.", "LIM_MAMMARY_STEM_CELL_DN": "Genes consistently down-regulated in mammary stem cells both in mouse and human species.", "LINDGREN_BLADDER_CANCER_CLUSTER_1_UP": "Up-regulated genes whose expression profile is specific to Custer I of urothelial cell carcinoma (UCC) tumors.", "LINDGREN_BLADDER_CANCER_CLUSTER_2A_UP": "Genes whose expression profile is specific to Cluster IIa of urothelial cell carcinoma (UCC) tumors.", "LIM_MAMMARY_STEM_CELL_UP": "Genes consistently up-regulated in mammary stem cells both in mouse and human species.", "LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN": "Genes whose expression profile is specific to Cluster IIa of urothelial cell carcinoma (UCC) tumors.", "LINDGREN_BLADDER_CANCER_CLUSTER_1_DN": "Down-regulated genes whose expression profile is specific to Custer I of urothelial cell carcinoma (UCC) tumors.", "LINDGREN_BLADDER_CANCER_CLUSTER_3_DN": "Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors.", "LINDGREN_BLADDER_CANCER_CLUSTER_2B": "Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors.", "LINDGREN_BLADDER_CANCER_HIGH_RECURRENCE": "Genes up-regulated among the high recurrence rate urothelial cell carcinoma (UCC) tumors.", "LINDGREN_BLADDER_CANCER_CLUSTER_3_UP": "Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors.", "LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q": "Genes down-regulated in urothelial cell carcinoma (UCC) tumors with LOH on 9q as compared to the tumors showing retention.", "LINDSTEDT_DENDRITIC_CELL_MATURATION_B": "Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated both at 8 hr and 48 hr after the stimulation (cluster B).", "LINDSTEDT_DENDRITIC_CELL_MATURATION_A": "Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated only at 8 hr after the stimulation (cluster A).", "LINDSTEDT_DENDRITIC_CELL_MATURATION_C": "Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated only at 48 hr after the stimulation (cluster C).", "LINDSTEDT_DENDRITIC_CELL_MATURATION_D": "Genes down-regulated during the course of maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli (cluster D).", "LINDVALL_IMMORTALIZED_BY_TERT_DN": "Genes down-regulated in BJ cells (foreskin fibroblasts) immortalized by expression of TERT [GeneID=7015].", "LIN_APC_TARGETS": "Genes up-regulated by forced expression of APC [GeneID=324] in the APC-deficient SW480  cell line (colon cancer).", "LINSLEY_MIR16_TARGETS": "Transcripts down-regulated by overexpression of MIR16 family of microRNA molecules in DLD-1 and HCT116 (colon cancer) cells hypomorphic for DICER1 [GeneID=23405].", "LINDVALL_IMMORTALIZED_BY_TERT_UP": "Genes up-regulated in BJ cells (foreskin fibroblasts) immortalized by expression of TERT [GeneID=7015].", "LIN_MELANOMA_COPY_NUMBER_DN": "Candidate genes in significant regions of chromosomal copy number losses in a panel of melanoma samples.", "LIN_NPAS4_TARGETS_DN": "Genes down-regulated in neurons after NPAS4 [GeneID=266743] knockdown by RNAi.", "LIN_MELANOMA_COPY_NUMBER_UP": "Candidate genes in significant regions of chromosomal copy number gains in a panel of melanoma samples.", "LIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK": "Genes up-regulated in highly immune-resistant cancer cell line developed from a susceptible cancer using an in vivo selection strategy.", "LIN_NPAS4_TARGETS_UP": "Genes up-regulated in neurons after NPAS4 [GeneID=266743] knockdown by RNAi.", "LIN_SILENCED_BY_TUMOR_MICROENVIRONMENT": "Genes downregulated in MCF10A cells (breast cancer) co-cultured with cancer-associated fibroblasts (CAF).", "LIU_BREAST_CANCER": "Low abundance transcripts specific for breast cancer.", "LIU_CMYB_TARGETS_DN": "Genes down-regulated in MCF-7 cells (breast cancer) by overexpression of CMYB [GeneID=4602] off adenovirus vector.", "LIU_CDX2_TARGETS_DN": "Genes down-regulated in HET1A cells (esophagus epithelium) engineered to stably express CDX2 [GeneID=1045].", "LIU_IL13_MEMORY_MODEL_UP": "Genes up-regulated in BEAS-2B cells (bronchial epithelium) stimulated with IL13 [GeneID=3596] on days 1 to 3 and then rested for the next 3 days (repeated-stimulation or memory model)", "LIU_CDX2_TARGETS_UP": "Genes up-regulated in HET1A cells (esophagus epithelium) engineered to stably express CDX2 [GeneID=1045].", "LIU_COMMON_CANCER_GENES": "Low abundance transcripts common to nasopharyngeal carcinoma (NPC), breast and liver tumors.", "LIU_IL13_MEMORY_MODEL_DN": "Genes down-regulated in BEAS-2B cells (bronchial epithelium) stimulated with IL13 [GeneID=3596] on days 1 to 3 and then rested for the next 3 days (repeated-stimulation or memory model)", "LIU_IL13_PRIMING_MODEL": "Genes up-regulated in BEAS-2B cells (bronchial epithelium) stimulated with IL13 [GeneID=3596] on days 1 to 3, rested on days 4 and 5, and then restimulated on day 6 for 1 h before lysis (priming model).", "LIU_CMYB_TARGETS_UP": "Genes up-regulated in MCF-7 cells (breast cancer) by overexpression of CMYB [GeneID=4602] off adenovirus vector.", "LIU_LIVER_CANCER": "Low abundance transcripts specific to hepatocellular carcinoma (HCC).", "LIU_NASOPHARYNGEAL_CARCINOMA": "Low abundance transcripts specific to nasopharyngeal carcinoma (NPC).", "LIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_KINASES_DN": "Targetable kinases differentially expressed between PDX and donor tumors from nine ovarian cancer patients.", "LIU_PROSTATE_CANCER_UP": "Genes up-regulated in prostate cancer samples.", "LIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_XDGS_UP": "Genes differentially expressed between PDX and donor tumor samples from nine ovarian cancer patients.", "LIU_SMARCA4_TARGETS": "Genes up-regulated in SW-13 cells (kidney cancer) by transient expression of SMARCA4 [GeneID=6597] at 24 h off a plasmid vector.", "LIU_TARGETS_OF_VMYB_VS_CMYB_UP": "Genes regulated in the opposite directions by v-MYB (UP) and c-MYB  (DN) variants of CMYB [GeneID=4602] overexpressed in primary monocyte cultures off adenoviral vectors.", "LIU_TARGETS_OF_VMYB_VS_CMYB_DN": "Gene regulated in the opposite directions by v-MYB (DN) and c-MYB  (UP) variants of CMYB [GeneID=4602] overexpressed in primary monocyte cultures off adenoviral vectors.", "LIU_TOPBP1_TARGETS": "Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of TOPBP1 [GeneID=11073].", "LIU_SOX4_TARGETS_DN": "Genes down-regulated in LNCaP cells (prostate cancer) by overexpression of SOX4 [GeneID=6659] and up-regulated by its RNAi knockdown.", "LIU_PROSTATE_CANCER_DN": "Genes down-regulated in prostate cancer samples.", "LIU_SOX4_TARGETS_UP": "Genes up-regulated in LNCaP cells (prostate cancer) by overexpression of SOX4 [GeneID=6659] and down-regulated by its RNAi knockdown.", "LIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_XDGS_DN": "Genes differentially expressed between PDX and donor tumor samples from nine ovarian cancer patients.", "LIU_VAV3_PROSTATE_CARCINOGENESIS_DN": "Selected genes down-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [GeneID=10451] in prostate epithelium.", "LI_ADIPOGENESIS_BY_ACTIVATED_PPARG": "Adipocyte genes induced in 3T3-L1 cells (adipocyte) by constitutively active PPARG [GeneID=5468] or its agonist, TZD [PubChem=5437].", "LIU_VAV3_PROSTATE_CARCINOGENESIS_UP": "Selected genes up-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [GeneID=10451] in prostate epithelium.", "LIU_VMYB_TARGETS_UP": "Genes up-regulated in MCF-7 cells (breast cancer) by overexpression of v-MYB oncogenic varian of CMYB [GeneID=4602] off adenovirus vector.", "LI_CISPLATIN_RESISTANCE_DN": "Genes consistently down-regulated in ACRP cells (ovarian cancer, resistant to cisplatin [PubChem=2767]) compared to the parental sensitive A2780 cells, regardless of cisplatin exposure.", "LI_AMPLIFIED_IN_LUNG_CANCER": "Genes with increased copy number that correlates with increased expression across six different lung adenocarcinoma cell lines.", "LI_CISPLATIN_RESISTANCE_UP": "Genes consistently up-regulated in ACRP cells (ovarian cancer, resistant to cisplatin [PubChem=2767]) compared to the parental sensitive A2780 cells, regardless of cisplatin exposure.", "LI_CYTIDINE_ANALOGS_CYCTOTOXICITY": "Genes whose expression in a panel of lymphoblastoid cell lines was associated with cytotoxicity of the anti-cancer analogs of cytidine, gemcitabine and cytarabine [PubChem=596;3461;6253].", "LI_DCP2_BOUND_MRNA": "Genes encoding mRNA transcripts specifically bound by DCP2 [GeneID=167227].", "LI_CYTIDINE_ANALOG_PATHWAY": "The 'cytidine analog pathway': genes involved in transport and metabolism of the anti-cancer analogs of cytidine: gemcitabine and cytarabine [PubChem=596;3461;6253].", "LI_ESTROGENE_BIDIRECTIONAL_E2_RESPONSE": "Bidirectional estrogen regulated genes in breast cancer cell lines merged from 146 NGS datasets-based comparisons (present in the top 10% of both upregulated and downregulated targets in at least 10% of comparisons).", "LI_ESTROGENE_EARLY_E2_RESPONSE_DN": "High confident estrogen down-regulated genes in early treatment duration (\u22646 hours) in breast cancer cells merged from 58 NGS datasets-based comparisons (10% topmost down-regulated genes and consistent in at least 40% comparisons).", "LI_ESTROGENE_EARLY_E2_RESPONSE_UP": "High confident estrogen up-regulated genes in early treatment duration (\u22646 hours) in breast cancer cells merged from 58 NGS datasets-based comparisons (10% topmost up-regulated genes and consistent in at least 50% comparisons).", "LI_ESTROGENE_LATE_E2_RESPONSE_UP": "High confident estrogen up-regulated genes in early treatment duration (\u2265 24 hours) in breast cancer cells merged from 44 NGS datasets-based comparisons (10% topmost up-regulated genes and consistent in at least 50% comparisons).", "LI_ESTROGENE_LATE_E2_RESPONSE_DN": "High confident estrogen down-regulated genes in early treatment duration (\u2265 24 hours) in breast cancer cells merged from 44 NGS datasets-based comparisons (10% topmost down-regulated genes and consistent in at least 40% comparisons).", "LI_ESTROGENE_MCF7_E2_RESPONSE_DN": "High confident estrogen down-regulated genes exclusively in MCF7 cells merged from 74 NGS datasets-based comparisons (10% topmost down-regulated genes and consistent in at least 50% comparisons).", "LI_ESTROGENE_MCF7_E2_RESPONSE_UP": "High confident estrogen up-regulated genes exclusively in MCF7 cells merged from 74 NGS datasets-based comparisons (10% topmost up-regulated genes and consistent in at least 50% comparisons).", "LI_ESTROGENE_META_E2_RESPONSE_DN": "High confident estrogen down-regulated genes in breast cancer cells merged from 146 NGS datasets-based comparisons (10% topmost down-regulated genes and consistent in at least 50% comparisons).", "LI_ESTROGENE_META_E2_RESPONSE_UP": "High confident estrogen up-regulated genes in breast cancer cells merged from 146 NGS datasets-based comparisons (10% topmost up-regulated genes and consistent in at least 50% comparisons).", "LI_ESTROGENE_MID_E2_RESPONSE_DN": "High confident estrogen down-regulated genes in middle treatment duration (6-24 hours) in breast cancer cells merged from 44 NGS datasets-based comparisons (10% topmost down-regulated genes and consistent in at least 40% comparisons).", "LI_ESTROGENE_NON_MCF7_T47D_E2_RESPONSE_DN": "High confident estrogen up-regulated genes in non-MCF7/T47D breast cancer cell lines merged from 44 NGS datasets-based comparisons (10% topmost up-regulated genes and consistent in at least 40% comparisons).", "LI_ESTROGENE_MID_E2_RESPONSE_UP": "High confident estrogen up-regulated genes in middle treatment duration (6-24 hours) in breast cancer cells merged from 44 NGS datasets-based comparisons (10% topmost up-regulated genes and consistent in at least 50% comparisons).", "LI_ESTROGENE_T47D_E2_RESPONSE_DN": "High confident estrogen down-regulated genes exclusively in T47D cells merged from 28 NGS datasets-based comparisons (10% topmost down-regulated genes and consistent in at least 50% comparisons).", "LI_ESTROGENE_NON_MCF7_T47D_E2_RESPONSE_UP": "High confident estrogen up-regulated genes in non-MCF7/T47D breast cancer cell lines merged from 44 NGS datasets-based comparisons (10% topmost up-regulated genes and consistent in at least 40% comparisons).", "LI_ESTROGENE_T47D_E2_RESPONSE_UP": "High confident estrogen up-regulated genes exclusively in T47D cells merged from 28 NGS datasets-based comparisons (10% topmost up-regulated genes and consistent in at least 50% comparisons).", "LI_PROSTATE_CANCER_EPIGENETIC": "Genes affected by epigenetic aberrations in prostate cancer.", "LI_WILMS_TUMOR": "'Wilm's tumor signature': genes highly expressed in Wilm's tumor samples compared to normal fetal kidney and a heterologous tumor, Burkit lymphoma.", "LI_LUNG_CANCER": "Proteins showing significant overexpression in lung cancer cell lines  relative to normal bronchial epithelial cell lines.", "LI_INDUCED_T_TO_NATURAL_KILLER_DN": "Genes down-regulated in ITNK cells (T-lymphocyte progenitors (DN3 cells) reprogrammed to natural killer (NK) cells by ablation of BCL11B [GeneID=64919] gene), compared to the parental DN3 cells.", "LI_WILMS_TUMOR_ANAPLASTIC_DN": "Selected down-regulated genes distinguishing between Wilms tumors of different histological types: anaplastic vs favorable histology.", "LI_WILMS_TUMOR_ANAPLASTIC_UP": "Selected up-regulated genes distinguishing between Wilms tumors of different histological types: anaplastic vs favorable histology.", "LI_INDUCED_T_TO_NATURAL_KILLER_UP": "Genes up-regulated in ITNK cells (T-lymphocyte progenitors (DN3 cells) reprogrammed to natural killer (NK) cells by ablation of BCL11B [GeneID=64919] gene), compared to the parental DN3 cells.", "LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP": "Genes up-regulated in Wilm's tumor samples compared to fetal  kidney.", "LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN": "Genes down-regulated in Wilm's tumor samples compared to fetal  kidney.", "LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_UP": "Genes up-regulated in Wilm's tumor vs fetal kidney.", "LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN": "Genes down-regulated in Wilm's tumor vs fetal kidney.", "LOPES_METHYLATED_IN_COLON_CANCER_DN": "Genes un-methylated aberrantly in HCT116 and Colo320 (colon cancer) cells.", "LOPES_METHYLATED_IN_COLON_CANCER_UP": "Genes methylated aberrantly in HCT116 and Colo320 (colon cancer) cells.", "LOPEZ_EPITHELIOID_MESOTHELIOMA": "Top 20 genes expressed higher in epithelioid than in sarcomatoid mesothelioma samples.", "LOPEZ_MBD_TARGETS_IMPRINTED_AND_X_LINKED": "X chromosome and imprinted genes up-regulated in HeLa cells (cervical cancer) after knockdown of the MBD (methyl-CpG binding domain) proteins by RNAi.", "LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER": "Overexpressed genes with amplified copy number across 27 non-small cell lung cancer (NSCLC) cell lines.", "LOPEZ_MESOTELIOMA_SURVIVAL_TIME_UP": "Top genes higher expressed in short term mesothelioma survivors.", "LOPEZ_MESOTHELIOMA_SURVIVAL_DN": "Top genes associated with unfavorable survival after surgery of patients with epithelioid mesothelioma.", "LOPEZ_MESOTHELIOMA_SURVIVAL_OVERALL_DN": "Top genes associated with unfavorable overall survival of mesothelioma patients after surgery.", "LOPEZ_MESOTELIOMA_SURVIVAL_TIME_DN": "Top genes higher expressed in long term mesothelioma survivors.", "LOPEZ_MESOTHELIOMA_SURVIVAL_OVERALL_UP": "Top genes associated with favorable overall survival of mesothelioma patients after surgery.", "LOPEZ_MESOTHELIOMA_SURVIVAL_UP": "Top genes associated with favorable survival after surgery of patients with epithelioid mesothelioma.", "LOPEZ_MESOTHELIOMA_SURVIVAL_WORST_VS_BEST_DN": "Genes higher expressed in the best 25 mesothelioma survivors compared to the 25 worst ones.", "LOPEZ_MESOTHELIOMA_SURVIVAL_WORST_VS_BEST_UP": "Genes higher expressed in the worst 25 mesothelioma survivors compared to the 25 best ones.", "LOPEZ_MBD_TARGETS": "Genes up-regulated in HeLa cells (cervical cancer) after simultaneus knockdown of all three MBD (methyl-CpG binding domain) proteins MeCP2, MBD1 and MBD2 [GeneID=4204;4152;8932] by RNAi.", "LOPEZ_TRANSLATION_VIA_FN1_SIGNALING": "Genes translationally up-regulated in HUVEC cells (endothelium) grown on FN1 [GeneID=2335] compared to those grown on laminin 1.", "LUCAS_HNF4A_TARGETS_DN": "Genes down-regulated in Tet-On HEK293 cells (embryonic kidney) by expression of HNF4A [GeneID=3172].", "LUDWICZEK_TREATING_IRON_OVERLOAD": "Genes changed in liver in response to nifedipine [PubChem=4485] treatment of iron overload.", "LUI_TARGETS_OF_PAX8_PPARG_FUSION": "Genes down-regulated in follicular thyroid carcinoma (FTC) samples that bear PAX8-PPARG [GeneID=7849;5468] fusion protein.", "LUCAS_HNF4A_TARGETS_UP": "Genes up-regulated in Tet-On HEK293 cells (embryonic kidney) by expression of HNF4A [GeneID=3172].", "LUI_THYROID_CANCER_CLUSTER_1": "Cluster 1: genes with similar expression profiles across follicular thyrorid carcinoma (FTC) samples.", "LUI_THYROID_CANCER_CLUSTER_5": "Cluster 5: genes with similar expression profiles across follicular thyroid carcinoma (FTC) samples.", "LUI_THYROID_CANCER_CLUSTER_2": "Cluster 2: genes with similar expression profiles across follicular thyroid carcinoma (FTC) samples.", "LUI_THYROID_CANCER_CLUSTER_3": "Cluster 3: genes with similar expression profiles across follicular thyrorid carcinoma (FTC) samples; genes in this cluster correlated well with the presence of PAX8-PPARG [GeneID=7849;5468] fusion protein.", "LUI_THYROID_CANCER_CLUSTER_4": "Cluster 4: genes with similar expression profiles across follicular thyroid carcinoma (FTC) samples.", "LUI_THYROID_CANCER_PAX8_PPARG_DN": "Top down-regulated genes distinguishing between follicular thyroid carcinoma (FTC) samples by the presence or absence of the PAX8-PPARG [GeneID=7849;5468] fusion protein.", "LUI_THYROID_CANCER_PAX8_PPARG_UP": "Top up-regulated genes distinguishing between follicular thyroid carcinoma (FTC) samples by the presence or absence of the PAX8-PPARG [GeneID=7849;5468] fusion protein.", "LUND_SILENCED_BY_METHYLATION": "Genes up-regulated in FE-8 cells (fibroblasts) upon treatment with azacitidine [PubChem=9444].", "LU_AGING_BRAIN_DN": "Age down-regulated genes in the human frontal cortex.", "LU_TUMOR_ENDOTHELIAL_MARKERS_DN": "Genes specifically down-regulated in tumor endothelium.", "LU_IL4_SIGNALING": "Genes up-regulated in peripheral B lymphocytes after incubation with IL4 [GeneID=3565] for 4 h.", "LU_TUMOR_ANGIOGENESIS_UP": "Up-regulated genes of putative pathways stimulated in tumor endothelial cells by papillary serous ovarian epithelial tumor cells.", "LU_TUMOR_VASCULATURE_DN": "Genes down-regulated in endothelial cells derived from invasive ovarian cancer tissue.", "LU_AGING_BRAIN_UP": "Age up-regulated genes in the human frontal cortex.", "LU_TUMOR_ENDOTHELIAL_MARKERS_UP": "Genes specifically up-regulated in tumor endothelium.", "LU_EZH2_TARGETS_DN": "Genes down-regulated in SKOV3ip1 cells (ovarian cancer) upon knockdown of EZH2 [GeneID=2146] by RNAi.", "LU_TUMOR_VASCULATURE_UP": "Genes up-regulated in endothelial cells derived from invasive ovarian cancer tissue.", "LU_EZH2_TARGETS_UP": "Genes up-regulated in SKOV3ip1 cells (ovarian cancer) upon knockdown of EZH2 [GeneID=2146] by RNAi.", "LY_AGING_MIDDLE_DN": "Genes down-regulated in fibroblasts from middle-age individuals, compared to those from the young donors.", "LY_AGING_MIDDLE_UP": "Genes up-regulated in fibroblasts from middle-age individuals, compared to those from the young donors.", "LY_AGING_OLD_UP": "Genes up-regulated in fibroblasts from old individuals, compared to those from young donors.", "LY_AGING_OLD_DN": "Genes down-regulated in fibroblasts from old individuals, compared to those from young donors.", "LY_AGING_PREMATURE_DN": "Genes down-regulated in fibroblasts from patients with Hutchinson-Gilford progeria (premature aging), compared to those from normal young individuals.", "MACLACHLAN_BRCA1_TARGETS_DN": "Genes down-regulated in SW480 cells (colon cancer with mutated p53 [GeneID=7157]) upon expression of BRCA1 [GeneID=672] off an adenovirus vector.", "MACLACHLAN_BRCA1_TARGETS_UP": "Genes up-regulated in SW480 cells (colon cancer with mutated p53 [GeneID=7157]) upon expression of BRCA1 [GeneID=672] off an adenovirus vector.", "MACAEVA_PBMC_RESPONSE_TO_IR": "Genes up-regulated in human peripheral blood mononuclear cells (PBMC)  at 8 h after exposure to 0.1 and 1.0 Gy dose of ionizing radiation.", "MADAN_DPPA4_TARGETS": "Genes differentially expressed in ES cells with DPPA4 [GeneID=55211] knockout.", "MAEKAWA_ATF2_TARGETS": "Genes down-regulated in MEF cells (embryonic fibroblast) upon knockout of ATF2 [GeneID=1386].", "MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_DN": "Down-regulated genes discriminating multiple myeloma samples by type of immunoglobulin they produce: IgG vs IgA.", "MAGRANGEAS_MULTIPLE_MYELOMA_IGLL_VS_IGLK_UP": "Up-regulated genes discriminating multiple myeloma samples by the ype of immunoglobulin light chain they produce: Ig lambda (IGLL) vs Ig kappa (IGLK).", "MAHADEVAN_GIST_MORPHOLOGICAL_SWITCH": "Genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line resistant to imatinib [PubChem=5291] that may correlate with the morphological switch in these cells.", "MAGRANGEAS_MULTIPLE_MYELOMA_IGLL_VS_IGLK_DN": "Down-regulated genes discriminating multiple myeloma samples by the ype of immunoglobulin light chain they produce: Ig lambda (IGLL) vs Ig kappa (IGLK).", "MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_UP": "Up-regulated genes discriminating multiple myeloma samples by type of immunoglobulin they produce: IgG vs IgA.", "MAHADEVAN_IMATINIB_RESISTANCE_UP": "Top genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line resistant to imatinib [PubChem=5291] compared to the parental cell line sensitive to the drug.", "MAHADEVAN_IMATINIB_RESISTANCE_DN": "Top genes down-regulated in the GIST (gastrointestinal stromal tumor) cell line resistant to imatinib [PubChem=5291] compared to the parental cell line sensitive to the drug.", "MAHAJAN_RESPONSE_TO_IL1A_UP": "Genes up-regulated in corneal fibroblasts after treatment with IL1A [GeneID=3552].", "MAHAJAN_RESPONSE_TO_IL1A_DN": "Genes down-regulated in corneal fibroblasts after treatment with IL1A [GeneID=3552].", "MAINA_HYPOXIA_VHL_TARGETS_UP": "Genes up-regulated by hypoxia in RCC4 cells (renal cell carcinoma) engineered to stably express VHL [GeneID=7428] off a plasmid vector.", "MAINA_VHL_TARGETS_DN": "Genes down-regulated in RCC4 cells (renal cell carcinoma) engineered to stably express VHL [GeneID=7428] off a plasmid vector.", "MAINA_VHL_TARGETS_UP": "Genes up-regulated in RCC4 cells (renal cell carcinoma) engineered to stably express VHL [GeneID=7428] off a plasmid vector.", "MALIK_REPRESSED_BY_ESTROGEN": "Genes consistently and robustly repressed by estradiol [PubChem=5757] in MCF7 cells (breast cancer); this reperession was prevented by fulvestrant [PubChem=3478439].", "MALTA_CURATED_STEMNESS_MARKERS": "Literature curated collection of genes marking normal and cancer stem cells.", "MALONEY_RESPONSE_TO_17AAG_UP": "Up-regulated genes in A2780 cells (ovarian cancer) treated with 17AAG [PubChem=6440175], a chemical with anticancer properties.", "MALONEY_RESPONSE_TO_17AAG_DN": "Down-regulated genes in A2780 cells (ovarian cancer) treated with 17AAG [PubChem=6440175], a chemical with anticancer properties.", "MANNE_COVID19_COMBINED_COHORT_VS_HEALTHY_DONOR_PLATELETS_DN": "Strongly downregulated genes from differential gene expression analysis of platelets from 10 combined ICU and Non-ICU COVID-19 patients and, for comparison, 5 healthy donors", "MANALO_HYPOXIA_DN": "Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091].", "MANNE_COVID19_ICU_VS_HEALTHY_DONOR_PLATELETS_DN": "Strongly downregualted genes from differential gene expression analysis of platelets from 4 ICU patients with SARS-CoV-2 infection as well as 5 healthy donors.", "MANALO_HYPOXIA_UP": "Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091].", "MANNE_COVID19_COMBINED_COHORT_VS_HEALTHY_DONOR_PLATELETS_UP": "Strongly upregulated genes from differential gene expression analysis of platelets from 10 combined ICU and Non-ICU COVID-19 patients and, for comparison, 5 healthy donors", "MANNE_COVID19_ICU_VS_HEALTHY_DONOR_PLATELETS_UP": "Strongly upregulated genes from differential gene expression analysis of platelets from 4 ICU patients with SARS-CoV-2 infection as well as 5 healthy donors.", "MANN_RESPONSE_TO_AMIFOSTINE_DN": "Genes down-regulated in HCT116 cells (colon cancer) after treatment with amifostine [PubChem=2141] depending on the presence of TP53 [GeneID=7157]: TP53-positive vs TP53-null cells.", "MANNE_COVID19_NONICU_VS_HEALTHY_DONOR_PLATELETS_DN": "Strongly downregulated genes from differential gene expression analysis of platelets from 6 Non-ICU patients with SARS-CoV-2 infection as well as 5 healthy donors.", "MANN_RESPONSE_TO_AMIFOSTINE_UP": "Genes up-regulated in HCT116 cells (colon cancer) after treatment with amifostine [PubChem=2141] depending on the presence of TP53 [GeneID=7157]: TP53-positive vs TP53-null cells.", "MANNE_COVID19_NONICU_VS_HEALTHY_DONOR_PLATELETS_UP": "Strongly upregulated genes from differential gene expression analysis of platelets from 6 Non-ICU patients with SARS-CoV-2 infection as well as 5 healthy donors.", "MARCHINI_TRABECTEDIN_RESISTANCE_UP": "Genes up-regulated in chondrosarcoma and ovarian carcinoma cell lines which developed resistance to trabectedin [PubChem=3199].", "MARCHINI_TRABECTEDIN_RESISTANCE_DN": "Genes down-regulated in chondrosarcoma and ovarian carcinoma cell lines which developed resistance to trabectedin [PubChem=3199].", "MARCINIAK_ER_STRESS_RESPONSE_VIA_CHOP": "Endoplasmic retuculum (ER) stress response (caused by  tunicamycin [PubChem=5282055]) genes dependent on CHOP [GeneID=13198].", "MARIADASON_RESPONSE_TO_BUTYRATE_CURCUMIN_SULINDAC_TSA_1": "Cluster 1: genes up-regulated in SW260 cells (colon cancer) by sodium butyrate, curcumin, sulindac and TSA [PubChem=5222465;969516;5352;5562].", "MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_UP": "Cluster 9: genes up-regulated in SW260 cells (colon cancer) by sodium butyrate and TSA [PubChem=5222465;5562] with the same kinetics with which each alters the level of histone H4 acetylation.", "MARIADASON_RESPONSE_TO_BUTYRATE_CURCUMIN_SULINDAC_TSA_8": "Cluster 8: genes down-regulated in SW260 cells (colon cancer) by sodium butyrate, curcumin, sulindac and TSA [PubChem=5222465;969516;5352;5562].", "MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_DN": "Cluster 10: genes down-regulated in SW260 cells (colon cancer) by sodium butyrate and TSA [PubChem=5222465;5562] with the same kinetics with which each alters the level of histone H4 acetylation.", "MARIADASON_RESPONSE_TO_BUTYRATE_CURCUMIN_SULINDAC_TSA_2": "Cluster 2: genes up-regulated in SW260 cells (colon cancer) by sodium butyrate, curcumin, sulindac and TSA [PubChem=5222465;969516;5352;5562].", "MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_4": "Cluster 4: genes down-regulated in SW260 cells (colon cancer) by sodium butyrate and sulindac [PubChem=5222465;5352].", "MARIADASON_RESPONSE_TO_CURCUMIN_SULINDAC_7": "Cluster 7: genes up-regulated in SW260 cells (colon cancer) by curcumin and sulindac [PubChem=969516;5352].", "MARIADASON_RESPONSE_TO_CURCUMIN_SULINDAC_5": "Cluster 5: genes up-regulated in SW260 cells (colon cancer) by curcumin and sulindac [PubChem=969516;5352].", "MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_6": "Cluster 6: genes down-regulated in SW260 cells (colon cancer) by sodium butyrate and sulindac [PubChem=5222465;5352].", "MARKEY_RB1_ACUTE_LOF_UP": "Genes up-regulated in adult fibroblasts with inactivated RB1 [GeneID=5925] by Cre-lox: acute loss of function (LOF) of RB1.", "MARKEY_RB1_CHRONIC_LOF_DN": "Genes down-regulated in MEF cells (embryonic fibroblasts) isolated from RB1 [GeneID=5925] knockout mice: chronic loss of function (LOF) of RB1.", "MARKS_HDAC_TARGETS_DN": "Genes whose transcription is down-regulated by histone deacetylase inhibitors.", "MARKEY_RB1_ACUTE_LOF_DN": "Genes down-regulated in adult fibroblasts with inactivated RB1 [GeneID=5925] by Cre-lox: acute loss of function (LOF) of RB1.", "MARKEY_RB1_CHRONIC_LOF_UP": "Genes up-regulated in MEF cells (embryonic fibroblasts) isolated from RB1 [GeneID=5925] knockout mice: chronic loss of function (LOF) of RB1.", "MARKS_ACETYLATED_NON_HISTONE_PROTEINS": "Non-histone proteins that are acetylated.", "MARKS_HDAC_TARGETS_UP": "Genes whose transcription is up-regulated by histone deacetylase inhibitors.", "MARSHALL_VIRAL_INFECTION_RESPONSE_UP": "Genes up-regulated in the influenza-specific CD8+ [GeneID=925] T lymphocytes from bronchoalveolar lavage (BAL) compared to those from spleen.", "MARSHALL_VIRAL_INFECTION_RESPONSE_DN": "Genes down-regulated in the influenza-specific CD8+ [GeneID=925] T lymphocytes from bronchoalveolar lavage (BAL) compared to those from spleen.", "MARSON_FOXP3_CORE_DIRECT_TARGETS": "Direct FOXP3 [GeneID=50943] targets that exhibit consistent transcriptional behavior in hybridoma and in ex vivo T lymphocytes.", "MARSON_FOXP3_TARGETS_DN": "Genes down-regulated by FOXP3 [GeneID=50943] in both ex vivo and hybridoma cells.", "MARSON_BOUND_BY_E2F4_UNSTIMULATED": "Genes with promoters bound by E2F4 [GeneID=1874] in unstimulated hybridoma cells.", "MARSON_FOXP3_TARGETS_UP": "Genes up-regulated by FOXP3 [GeneID=50943] in both ex vivo and hybridoma cells.", "MARSON_FOXP3_TARGETS_STIMULATED_UP": "Genes with promoters bound by FOXP3 [GeneID=50943], dependent on it, and up-regulated in hybridoma cells stimulated by PMA [PubChem=4792] and ionomycin [PubChem=3733].", "MARSON_FOXP3_TARGETS_STIMULATED_DN": "Genes with promoters bound by FOXP3 [GeneID=50943], dependent on it, and down-regulated in hybridoma cells stimulated by PMA [PubChem=4792] and ionomycin [PubChem=3733].", "MARSON_BOUND_BY_FOXP3_STIMULATED": "Genes with promoters bound by FOXP3 [GeneID=50943] in hybridoma cells stimulated by PMA [PubChem=4792] and ionomycin [PubChem=3733].", "MARSON_BOUND_BY_FOXP3_UNSTIMULATED": "Genes with promoters bound by FOXP3 [GeneID=50943] in unstimulated hybridoma cells.", "MARTENS_TRETINOIN_RESPONSE_DN": "Genes down-regulated in NB4 cells (acute promyelocytic leukemia, APL) in response to tretinoin [PubChem=444795]; based on Chip-seq data.", "MARTINELLI_IMMATURE_NEUTROPHIL_DN": "Neutrophil-specific genes down-regulated in comparison of immature with mature neutrophils.", "MARTENS_BOUND_BY_PML_RARA_FUSION": "Genes with promoters occupied by PML-RARA fusion [GeneID=5371] [GeneID=5914] protein in acute promyelocytic leukemia(APL) cells NB4 and two APL primary blasts, based on  Chip-seq data.", "MARTINELLI_IMMATURE_NEUTROPHIL_UP": "Neutrophil-specific genes up-regulated in comparison of immature with mature neutrophils.", "MARTENS_TRETINOIN_RESPONSE_UP": "Genes up-regulated in NB4 cells (acute promyelocytic leukemia, APL) in response to tretinoin [PubChem=444795]; based on Chip-seq data.", "MARTINEZ_RESPONSE_TO_TRABECTEDIN": "Genes down-regulated by trabectedin [PubChem=3199] and its synthetic analog phthalascidin Pt 650 in HCT116 cells (colon cancer).", "MARTINEZ_RB1_AND_TP53_TARGETS_DN": "Genes down-regulated in mice with skin specific double knockout of both RB1 and TP53 [GeneID=5925;7157] by Cre-lox.", "MARTINEZ_RB1_TARGETS_UP": "Genes up-regulated in mice with skin specific knockout of RB1 [GeneID=5925] by Cre-lox.", "MARTINEZ_RB1_TARGETS_DN": "Genes down-regulated in mice with skin specific knockout of RB1 [GeneID=5925] by Cre-lox.", "MARTINEZ_RB1_AND_TP53_TARGETS_UP": "Genes up-regulated in mice with skin specific double knockout of both RB1 and TP53 [GeneID=5925;7157] by Cre-lox.", "MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP": "Genes up-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199].", "MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN": "Genes down-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199].", "MARTIN_NFKB_TARGETS_DN": "NF-kB-controlled genes down-regulated in endothelial cells in response to viral GPCR protein.", "MARTIN_INTERACT_WITH_HDAC": "Interaction partners of class IIa histone deacetylases (HDAC).", "MARTINEZ_TP53_TARGETS_UP": "Genes up-regulated in mice with skin specific knockout of TP53 [GeneID=7157].", "MARTIN_NFKB_TARGETS_UP": "NF-kB-controlled genes up-regulated in endothelial cells in response to viral GPCR protein.", "MARTINEZ_TP53_TARGETS_DN": "Genes down-regulated in mice with skin specific knockout of TP53 [GeneID=7157].", "MARTIN_VIRAL_GPCR_SIGNALING_UP": "Up-regulated genes in the expression signature of direct and paracrine viral GPCR signaling in endothelial cells.", "MARTIN_VIRAL_GPCR_SIGNALING_DN": "Down-regulated genes in the expression signature of direct and paracrine viral GPCR signaling in endothelial cells.", "MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP": "Genes up-regulated in non-apoptotic tissues (fetal liver) after MDM4 [GeneID=4194] knockout.", "MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN": "Genes down-regulated in non-apoptotic tissues (fetal liver) after MDM4 [GeneID=4194] knockout.", "MARZEC_IL2_SIGNALING_DN": "Genes down-regulated by IL2 [GeneID=3558] in cells derived from  CD4+ [GeneID=920] cutaneous T-cell lymphoma (CTCL).", "MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP": "Genes up-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout.", "MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN": "Genes down-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout.", "MARZEC_IL2_SIGNALING_UP": "Genes up-regulated by IL2 [GeneID=3558] in cells derived from  CD4+ [GeneID=920] cutaneous T-cell lymphoma (CTCL).", "MASSARWEH_RESPONSE_TO_ESTRADIOL": "Genes rapidly up-regulated in breast cancer cell cultures by estradiol [PubChem=5757].", "MATHEW_FANCONI_ANEMIA_GENES": "Genes identified with the Fanconi anemia (FA) and the FA pathway.", "MASRI_RESISTANCE_TO_TAMOXIFEN_AND_AROMATASE_INHIBITORS_UP": "Genes up-regulated in derivatives of MCF-7aro cells (breast cancer) that developed resistance to tamoxifen [PubChem=5376] or  inhibitors of aromatase (CYP19A1) [GeneID=1588].", "MASSARWEH_TAMOXIFEN_RESISTANCE_DN": "Genes down-regulated in breast cancer tumors (formed by MCF-7 xenografts) resistant to tamoxifen [PubChem=5376].", "MASRI_RESISTANCE_TO_TAMOXIFEN_AND_AROMATASE_INHIBITORS_DN": "Genes down-regulated in derivatives of MCF-7aro cells (breast cancer) that developed resistance to tamoxifen [PubChem=5376] or  inhibitors of aromatase (CYP19A1) [GeneID=1588].", "MATTHEWS_AP1_TARGETS": "Known targets of AP1 that were down-regulated by overexpression of TAM67, a dominant-negative form of JUN [GeneID=3725].", "MATTHEWS_SKIN_CARCINOGENESIS_VIA_JUN": "Genes up-regulated by skin tumor promoters but completely blocked by expression of TAM67, a dominan-negative form of JUN [GeneID=3725].", "MATTIOLI_MGUS_VS_MULTIPLE_MYELOMA": "Genes distinguishing between MGUS (monoclonal gammopathy of undetermined significance) and multiple myeloma (MM) samples.", "MASSARWEH_TAMOXIFEN_RESISTANCE_UP": "Genes up-regulated in breast cancer tumors (formed by MCF-7 xenografts) resistant to tamoxifen [PubChem=5376].", "MATSUDA_NATURAL_KILLER_DIFFERENTIATION": "Genes changed between developmental stages of Valpha14i  natural killer T lymphocyte cells (NKT).", "MATTIOLI_MULTIPLE_MYELOMA_SUBGROUPS": "Genes differentially expressed in multiple myeloma (MM) patients: comparison of MGUS-like vs PCL-like samples; MGUS=monoclonal gammopathy of undetermined significance, PCL=plasma cell leukemia.", "MATTIOLI_MGUS_VS_PCL": "Genes changed in MGUS (monoclonal gammopathy of undetermined significance) compared to PCL (plasma cell leukemia) samples.", "MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q32_TRANSLOCATIONS": "Genes expressed in multiple myeloma (MM) patients carrying specific translocations involving the immunoglobulin heavy chain (IGH) locus at 14q32.", "MATZUK_CUMULUS_EXPANSION": "Genes important for cumulus expansion, based on mouse models with female fertility defects.", "MATZUK_CENTRAL_FOR_FEMALE_FERTILITY": "Genes central for female fertility pathways, based on mouse models with female fertility defects.", "MATZUK_EARLY_ANTRAL_FOLLICLE": "Genes important for early anral follicle, based on mouse models with female fertility defects.", "MATZUK_EMBRYONIC_GERM_CELL": "Genes important for embryonic germ cell, based on mouse models with female fertility defects.", "MATZUK_FERTILIZATION": "Genes important for fertilization, based on mouse models with female fertility defects.", "MATZUK_IMPLANTATION_AND_UTERINE": "Genes important for implantation and uterine, based on mouse models with female fertility defects.", "MATZUK_LUTEAL_GENES": "Luteal genes, based on mouse models with female fertility defects.", "MATZUK_MATERNAL_EFFECT": "Maternal effect genes, based on mouse models wih female fertility defects.", "MATZUK_MALE_REPRODUCTION_SERTOLI": "Genes important for Sertoli, peritubular, Leydig and interstitial cells, based on mouse models with male reproductive defects.", "MATZUK_MEIOTIC_AND_DNA_REPAIR": "Meitic and DNA repair genes important for female fertility, based on mouse models with female fertility defects.", "MATZUK_OVULATION": "Genes important for ovulation, based on mouse models with female fertility defects.", "MATZUK_POSTIMPLANTATION_AND_POSTPARTUM": "Genes important for post-implantation and post-partum,  based on mouse models with female fertility defects.", "MATZUK_PREOVULATORY_FOLLICLE": "Genes important for preovulatory follicle,  based on mouse models with female fertility defects.", "MATZUK_SPERMATID_DIFFERENTIATION": "Genes important for spermatid differentiation, based on mouse models with male reproductive defects.", "MATZUK_SPERMATOCYTE": "Genes important for spermatocyte, based on mouse models with male reproductive defects.", "MATZUK_SPERMATOGONIA": "Genes important for spermatogonia, based on mouse models with male reproductive defects.", "MATZUK_SPERMATOZOA": "Spermatozoa genes, based on mouse models with male reproductive defects.", "MATZUK_STEROIDOGENESIS": "Genes important for steroidogenesis, based on mouse models with female fertility defects.", "MAYBURD_RESPONSE_TO_L663536_DN": "Genes down-regulated in H720 cells (lung cancer) after treatment with L663536 (MK886) [PubChem=105049], an inhibitor of leukotriene biosynthesis.", "MAYBURD_RESPONSE_TO_L663536_UP": "Genes up-regulated in H720 cells (lung cancer) after treatment with L663536 (MK886) [PubChem=105049], an inhibitor of leukotriene biosynthesis.", "MA_MYELOID_DIFFERENTIATION_UP": "Genes up-regulated during myeloid differentiation induced by tretinoin (ATRA) [PubChem=444795] and IL3 [GeneID=3652] in the EML cell line (myeloid progenitor).", "MA_MYELOID_DIFFERENTIATION_DN": "Genes down-regulated during myeloid differentiation induced by tretinoin (ATRA) [PubChem=444795] and IL3 [GeneID=3652] in the EML cell line (myeloid progenitor).", "MCBRYAN_PUBERTAL_BREAST_3_4WK_DN": "Genes down-regulated during pubertal mammary gland development between weeks 3 and 4.", "MCBRYAN_PUBERTAL_BREAST_3_4WK_UP": "Genes up-regulated during pubertal mammary gland development between weeks 3 and 4.", "MA_RAT_AGING_DN": "Genes down-regulated across multiple cell types from nine tissues during rat aging.", "MA_RAT_AGING_UP": "Genes up-regulated across multiple cell types from nine tissues during rat aging.", "MCBRYAN_PUBERTAL_BREAST_4_5WK_DN": "Genes down-regulated during pubertal mammary gland development between week 4 and 5.", "MCBRYAN_PUBERTAL_BREAST_4_5WK_UP": "Genes up-regulated during pubertal mammary gland development between week 4 and 5.", "MCBRYAN_PUBERTAL_BREAST_6_7WK_DN": "Genes down-regulated during pubertal mammary gland development between week 6 and 7.", "MCBRYAN_PUBERTAL_BREAST_5_6WK_UP": "Genes up-regulated during pubertal mammary gland development between week 5 and 6.", "MCBRYAN_PUBERTAL_BREAST_6_7WK_UP": "Genes up-regulated during pubertal mammary gland development between week 6 and 7.", "MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN": "Pubertal genes down-regulated by TGFB1 [GeneID=7040].", "MCBRYAN_PUBERTAL_BREAST_5_6WK_DN": "Genes down-regulated during pubertal mammary gland development between week 5 and 6.", "MCBRYAN_TERMINAL_END_BUD_DN": "The 'TEB profile genes': down-regulated during pubertal mammary gland development specifically in the TEB (terminal end bud) structures.", "MCBRYAN_TERMINAL_END_BUD_UP": "The 'TEB profile genes': up-regulated during pubertal mammary gland development specifically in the TEB (terminal end bud) structures.", "MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP": "Pubertal genes up-regulated by TGFB1 [GeneID=7040].", "MCCABE_HOXC6_TARGETS_CANCER_DN": "Genes whose promoters were bound by HOXC6 [GeneID=3223] in LNCaP cells (prostate cancer) and which were down-regulated in comparison of tumor vs normal prostate tissue samples.", "MCCABE_HOXC6_TARGETS_DN": "Genes with promoters bound by HOXC6 [GeneID=3223] in LNCaP cells (prostate cancer) and down-regulated upon loss of function (LOF) of HOXC6.", "MCCABE_HOXC6_TARGETS_UP": "Genes with promoters bound by HOXC6 [GeneID=3223] in LNCaP cells (prostate cancer) and up-regulated upon loss of function (LOF) of HOXC6.", "MCCABE_BOUND_BY_HOXC6": "Genes whose promoters where bound by HOXC6 [GeneID=3223] in LNCaP cells (prostate cancer), according to a ChIP-chip analysis.", "MCCABE_HOXC6_TARGETS_CANCER_UP": "Genes whose promoters were bound by HOXC6 [GeneID=3223] in LNCaP cells (prostate cancer) and which were up-regulated in comparison of tumor vs normal prostate tissue samples.", "MCCLUNG_COCAINE_REWARD_5D": "Genes up-regulated in the nucleus accumbens (a major reward center in the brain) after 5 days of cocaine [PubChem=5760] treatment.", "MCCLUNG_COCAIN_REWARD_4WK": "Genes up-regulated in the nucleus accumbens (a major reward center in the brain) after 4 weeks of cocaine [PubChem=5760] treatment.", "MCCLUNG_CREB1_TARGETS_DN": "Genes down-regulated in the nucleus accumbens (a major reward center in the brain) 8 weeks after induction of CREB1 [GeneID=1385] expression in a transgenic Tet-Off system.", "MCCOLLUM_GELDANAMYCIN_RESISTANCE_DN": "Genes down-regulated in A549GARS cells (lung cancer) resistant to the geldanamycin and 17-AAG [PubChem=5476289;6440175].", "MCCLUNG_CREB1_TARGETS_UP": "Genes up-regulated in the nucleus accumbens (a major reward center in the brain) 8 weeks after induction of CREB1 [GeneID=1385] expression in a transgenic Tet-Off system.", "MCCLUNG_DELTA_FOSB_TARGETS_2WK": "Genes up-regulated in the nucleus accumbens (a major reward center in brain) 2 weeks after induction of deltaFosB, a FOSB [GeneID=2354] splice variant.", "MCCLUNG_DELTA_FOSB_TARGETS_8WK": "Genes up-regulated in the nucleus accumbens (a major reward center in brain) 8 weeks after induction of deltaFosB, a FOSB [GeneID=2354] splice variant.", "MCCOLLUM_GELDANAMYCIN_RESISTANCE_UP": "Genes up-regulated in A549GARS cells (lung cancer) resistant to the geldanamycin and 17-AAG [PubChem=5476289;6440175].", "MCDOWELL_ACUTE_LUNG_INJURY_DN": "Genes down-regulated in the mouse model of acute lung injury induced by inhaling nickel sulfate [PubChem=24586].", "MCDOWELL_ACUTE_LUNG_INJURY_UP": "Genes up-regulated in the mouse model of acute lung injury induced by inhaling nickel sulfate [PubChem=24586].", "MCGOWAN_RSP6_TARGETS_DN": "Genes down-regulated by hemizygotic cre-lox knockout of RSP6 [GeneID=81492] in keratinocytes.", "MCGARVEY_SILENCED_BY_METHYLATION_IN_COLON_CANCER": "Genes silenced in HCT116 cells (colon cancer) by methylation of CpG islands in their promoters.", "MCGOWAN_RSP6_TARGETS_UP": "Genes up-regulated by hemizygotic cre-lox knockout of RSP6 [GeneID=81492] in keratinocytes.", "MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_UP": "Up-regulated 'cooperation response genes': responded synergystically to the combination of mutant TP53 and HRAS [GeneID=7157;3265] in YAMC cells (colon).", "MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN": "Down-regulated 'cooperation response genes': responded synergystically to the combination of mutant TP53 and HRAS [GeneID=7157;3265] in YAMC cells (colon).", "MCLACHLAN_DENTAL_CARIES_DN": "Genes down-regulated in pulpal tissue extracted from carious teeth.", "MCLACHLAN_DENTAL_CARIES_UP": "Genes up-regulated in pulpal tissue extracted from carious teeth.", "MEBARKI_HCC_PROGENITOR_WNT_DN_BLOCKED_BY_FZD8CRD": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_WNT_DN": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_WNT_DN_CTNNB1_DEPENDENT": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_FZD8CRD_DN": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_WNT_DN_CTNNB1_DEPENDENT_BLOCKED_BY_FZD8CRD": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_WNT_DN_CTNNB1_INDEPENDENT": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_FZD8CRD_UP": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_WNT_UP": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_WNT_UP_BLOCKED_BY_FZD8CRD": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_DEPENDENT": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_DEPENDENT_BLOCKED_BY_FZD8CRD": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEINHOLD_OVARIAN_CANCER_LOW_GRADE_DN": "Genes down-regulated in low grade (LMP and G1) serous ovarian carcinomas vs the higher grade invasive tumors (G2 and G3).", "MEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_INDEPENDENT": "Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.", "MEINHOLD_OVARIAN_CANCER_LOW_GRADE_UP": "Genes up-regulated in low grade (LMP and G1) serous ovarian carcinomas vs the higher grade invasive tumors (G2 and G3).", "MEDINA_SMARCA4_TARGETS": "Genes up-regulated in H1299 cells (lung cancer) by expression of SMARCA4 [GeneID=6597] off a plasmid vector.", "MEISSNER_BRAIN_HCP_WITH_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing the H3K27 tri-methylation (H3K27me3) mark in brain.", "MEISSNER_BRAIN_HCP_WITH_H3K4ME2": "Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation mark (H3K4me2) in brain.", "MEISSNER_BRAIN_HCP_WITH_H3K4ME2_AND_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing bivalent histone H3 dimethylation mark at K4 (H3K4me2) and trimethlation mark at K27 (H3K27me3) in brain.", "MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED": "Genes with high-CpG-density promoters (HCP) that have no histone H3 methylation marks in brain.", "MEISSNER_ES_ICP_WITH_H3K4ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in ES cells (embryonic stem).", "MEISSNER_BRAIN_ICP_WITH_H3K4ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in brain.", "MEISSNER_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing histone trimethylation marks at K4 (H3K4me3) and K27 (H3K27me3)ES cells (embryonic stem).", "MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation at K4 (H3K4me2) and trimethylation at K27 (H3K27me3) in brain.", "MEISSNER_NPC_HCP_WITH_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing the H3K27 tri-methylation (H3K27me3) mark in neural precursor cells (NPC).", "MEISSNER_NPC_HCP_WITH_H3K4ME2": "Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation mark at K4 (H3K4me2) in neural precursor cells (NPC).", "MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing histone H3 trimethylation marks at k4 (H3K4me3) and K27 ((H3K27me3) in neural precursor cells (NPC).", "MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing histone H3 dimethylation mark at K4 (H3K4me2) and trimethylation mark at K27 (H3K27me3) in neural precursor cells (NPC).", "MELLMAN_TUT1_TARGETS_UP": "Genes up-regulated in HEK293 cells (embryo kidney) after knockdown of TUT1 [GeneID=64852] by RNAi.", "MEISSNER_NPC_ICP_WITH_H3K4ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in neural precursor cells (NPC).", "MELLMAN_TUT1_TARGETS_DN": "Genes down-regulated in HEK293 cells (embryo kidney) after knockdown of TUT1 [GeneID=64852] by RNAi.", "MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED": "Genes with high-CpG-density promoters (HCP) that have no histone H3 methylation marks in neural precursor cells (NPC).", "MEISSNER_NPC_ICP_WITH_H3_UNMETHYLATED": "Genes with intermediate-CpG-density promoters (ICP) that have no histone H3 methylation marks in neural precursor cells (NPC).", "MENSE_HYPOXIA_UP": "Hypoxia response genes up-regulated in both astrocytes and HeLa cell line.", "MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER": "Candidate genes in genomic amplification regions in hepatocellular carcinoma (HCC) samples.", "MIKHAYLOVA_OXIDATIVE_STRESS_RESPONSE_VIA_VHL_DN": "Proteins significantly repressed by oxidative stress (hydrogen peroxide [PubChem=784] in 786-O cells (renal clear cell carcinoma, RCC) expressing VHL [GeneID=7428].", "MIKHAYLOVA_OXIDATIVE_STRESS_RESPONSE_VIA_VHL_UP": "Proteins significantly induced by oxidative stress (hydrogen peroxide [PubChem=784] in 786-O cells (renal clear cell carcinoma, RCC) expressing VHL [GeneID=7428].", "MIKI_COEXPRESSED_WITH_CYP19A1": "Nuclear receptors whose expression correlated with that of aromatase (CYP19A1) [GeneID=1588] in a panel of breast cancer biopsies.", "MIKKELSEN_DEDIFFERENTIATED_STATE_UP": "Genes up-regulated in partially reprogrammed and pluripotent cell populations (induced, iPS; and embryonic stem cells, ES) compared to parental lineage-commited cell lines.", "MIKKELSEN_DEDIFFERENTIATED_STATE_DN": "Genes down-regulated in partially reprogrammed and pluripotent cell populations (induced, iPS; and embryonic stem cells, ES) compared to parental lineage-commited cell lines.", "MIKKELSEN_ES_ICP_WITH_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing histone H3 K27 trimethylation mark (H3K27me3) in embryonic stem cells (ES).", "MIKKELSEN_ES_HCP_WITH_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing histone H3 K27 trimethylation mark (H327me3) in embryonic stem cells (ES).", "MIKKELSEN_ES_HCP_WITH_H3_UNMETHYLATED": "Genes with high-CpG-density promoters (HCP) without H3 methylation marks at K4 and K27 in embryonic stem cells (ES).", "MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing bivalent histone H3 methylation mark (H3K4me3 and H3K27me3) in embryonic stem cells (ES).", "MIKKELSEN_ES_LCP_WITH_H3K27ME3": "Genes with low-CpG-density promoters bearing H3 trimethylation mark at K27 (H3K27me3) in embryonic stem cells (ES).", "MIKKELSEN_ES_LCP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with low-CpG-density promoters (LCP) bearing the bivalent histone H3 trimethylation mark at K4 and K27 (H3K4me3 and H3K27me3) in embryonic stem cells (ES).", "MIKKELSEN_ES_LCP_WITH_H3K4ME3": "Genes with low-CpG-density promoters (LCP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in embryonic stem cells (ES).", "MIKKELSEN_ES_ICP_WITH_H3K4ME3": "Genes with intermediate-CpG-density (ICP) promoters bearing histone H3 K4 trimethylation mark (H3K4me3) in embryonic stem cells (ES).", "MIKKELSEN_IPS_ICP_WITH_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV8.1 cells (induced pluripotent cells, iPS).", "MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED": "Genes with high-CpG-density promoters (HCP) without H3 methylation marks at either H3K4 or H3K27 in MCV8.1 cells (induced pluripotent cells, iPS).", "MIKKELSEN_IPS_LCP_WITH_H3K27ME3": "Genes with low-CpG-density promoters (LCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV8.1 cells (induced pluripotent cells, iPS).", "MIKKELSEN_IPS_LCP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with low-CpG-density promoters (LCP) bearing the bivalent tri-methylation marks at H3K4 (H3K4me3) and H3K27 (H3K27me3) in MCV8.1 cells (induced pluripotent cells, iPS).", "MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing the bivalent tri-methylation marks at H3K4 (H3K4me3) and H3K27 (H3K27me3) in MCV8.1 cells (induced pluripotent cells, iPS).", "MIKKELSEN_IPS_LCP_WITH_H3K4ME3": "Table 2S. Genes in MEF, MCV6, MCV8.1 and ES cells by  epigenetic mark of their promoter", "MIKKELSEN_IPS_WITH_HCP_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV8.1 (induced pluripotent cells, iPS).", "MIKKELSEN_MCV6_ICP_WITH_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state).", "MIKKELSEN_MCV6_ICP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing the bivalent trimethylation marks at H3K4 (H3K4me3) and H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state).", "MIKKELSEN_MCV6_HCP_WITH_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state).", "MIKKELSEN_MCV6_LCP_WITH_H3K27ME3": "Genes with low-CpG-density promoters (LCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state).", "MIKKELSEN_MCV6_LCP_WITH_H3K4ME3": "Genes with low-CpG-density promoters (LCP) bearing the tri-methylation mark at H3K4 (H3K4me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state).", "MIKKELSEN_MEF_HCP_WITH_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing histone H3 trimethylation mark at K27 (H3K27me3) in MEF cells (embryonic fibroblast).", "MIKKELSEN_MEF_ICP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing the bivalent tri-methylation marks at H3K4 (H3K4me3) and H3K27 (H3K27me3) in MEF cells (embryonic fibroblasts).", "MIKKELSEN_MEF_ICP_WITH_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MEF cells (embryonic fibroblasts).", "MIKKELSEN_MEF_LCP_WITH_H3K27ME3": "Genes with low-CpG-density promoters (LCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MEF cells (embryonic fibroblasts).", "MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED": "Genes with high-CpG-density promoters (HCP) with unmethylated histone H3 in MEF cells (embryonic fibroblast).", "MIKKELSEN_NPC_ICP_WITH_H3K27ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing histone H3 trimethylation mark at K27 (H3K27me3) in neural progenitor cells (NPC).", "MIKKELSEN_MEF_LCP_WITH_H3K4ME3": "Genes with low-CpG-density promoters (LCP) bearing tri-methylation mark at H3K4 (H3K4me3) in MEF cells (embryonic fibroblasts).", "MIKKELSEN_NPC_HCP_WITH_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing histone H3 trimethylation mark at K27 (H3K27me3) in neural progenitor cells (NPC).", "MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3": "Genes with high-CpG-density promoters (HCP) bearing the bivalent histone H3 trimethylation mark at K4 and K27 (H3K4me3 and H3K27me3) in neural progenitor cells (NPC).", "MIKKELSEN_NPC_LCP_WITH_H3K4ME3": "Genes with low-CpG-density promoters (LCP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in neural progenitor cells (NPC).", "MIKKELSEN_NPC_ICP_WITH_H3K4ME3": "Genes with intermediate-CpG-density promoters (ICP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in neural progenitor cells (NPC).", "MIKKELSEN_NPC_WITH_LCP_H3K27ME3": "Genes with low-CpG-density promoters (LCP) bearing histone H3 trimethylation mark at K27 in neural progenitor cells (NPC).", "MIKKELSEN_PARTIALLY_REPROGRAMMED_TO_PLURIPOTENCY": "Genes up-regulated in cells that have been partially reprogrammed to pluripotency: comparison with the parental lineage-committed cell lines, fully reprogrammed stem cells, and embryonic stem cells.", "MIKKELSEN_PLURIPOTENT_STATE_DN": "Genes down-regulated in the induced pluripotent cells (iPS) and embryonic stem cells (ES) compared to the parental lineage-committed and partially reprogrammed cell lines.", "MILICIC_FAMILIAL_ADENOMATOUS_POLYPOSIS_DN": "Top genes down-regulated in colon epithelium biopsies from FAP (familial adenomatous polyposis) patients with mutated APC [GeneID=324].", "MILICIC_FAMILIAL_ADENOMATOUS_POLYPOSIS_UP": "Top genes up-regulated in colon epithelium biopsies from FAP (familial adenomatous polyposis) patients with mutated APC [GeneID=324].", "MIKKELSEN_PLURIPOTENT_STATE_UP": "Genes up-regulated in the induced pluripotent cells (iPS) and embryonic stem cells (ES) compared to the parental lineage-committed and partially reprogrammed cell lines.", "MILI_PSEUDOPODIA": "Transcripts significantly enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to both chemotactic (lysophosphatidic acid, LPA [PubChem=3988]) and haptotactic (fibronectin, FN1 [GeneID=2335) migratory stimuli.", "MILI_PSEUDOPODIA_CHEMOTAXIS_UP": "Transcripts enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to the chemotactic migration stimulus by lysophosphatidic acid (LPA) [PubChem=3988].", "MILI_PSEUDOPODIA_CHEMOTAXIS_DN": "Transcripts depleted in pseudopodia of NIH/3T3 cells (fibroblast) in response to the chemotactic migration stimulus by lysophosphatidic acid (LPA) [PubChem=3988].", "MINGUEZ_LIVER_CANCER_VASCULAR_INVASION_DN": "Genes under-expressed in hepatocellular carcinoma (HCC) with vascular invasion.", "MISIAK_ANAPLASTIC_THYROID_CARCINOMA_DN": "Genes down-regulated in anaplastic thyroid carcinoma and sharply distinguishing ATC from other thyroid carcinomas.", "MINGUEZ_LIVER_CANCER_VASCULAR_INVASION_UP": "Genes over-expressed in hepatocellular carcinoma (HCC) with vascular invasion.", "MILI_PSEUDOPODIA_HAPTOTAXIS_DN": "Transcripts depleted from pseudopodia of NIH/3T3 cells (fibroblast) in response to haptotactic migratory stimulus by fibronectin, FN1 [GeneID=2335].", "MISIAK_ANAPLASTIC_THYROID_CARCINOMA_UP": "Genes up-regulated in anaplastic thyroid carcinoma and sharply distinguishing ATC from other thyroid carcinomas.", "MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_DN": "Top genes down-regulated in mesenchyme stem cells (MSC) grown in a tumor conditioned medium, which leads to carcinoma-associated fibroblast phenotype.", "MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP": "Top genes up-regulated in mesenchyme stem cells (MSC) grown in a tumor conditioned medium, which leads to carcinoma-associated fibroblast phenotype.", "MILI_PSEUDOPODIA_HAPTOTAXIS_UP": "Transcripts enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to haptotactic migratory stimulus by fibronectin, FN1 [GeneID=2335].", "MISSIAGLIA_REGULATED_BY_METHYLATION_DN": "Genes down-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668], a DNA hypomethylating agent similar to azacitidine [PubChem=9444].", "MISSIAGLIA_REGULATED_BY_METHYLATION_UP": "Genes up-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668], a DNA hypomethylating agent similar to azacitidine [PubChem=9444].", "MITSIADES_RESPONSE_TO_APLIDIN_DN": "Genes down-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties.", "MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN": "Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313] [GeneID=2078].", "MIZUSHIMA_AUTOPHAGOSOME_FORMATION": "Key proteins in mammalian autophagosome formation.", "MMS_MOUSE_LYMPH_HIGH_4HRS_UP": "Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of methyl methanesulfonate (MMS)", "MIZUKAMI_HYPOXIA_DN": "Genes down-regulated in DLD-1 cells (colon cancer) in response to hypoxia; might not be direct targets of HIF1A [GeneID=3091].", "MITSIADES_RESPONSE_TO_APLIDIN_UP": "Genes up-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties.", "MIZUKAMI_HYPOXIA_UP": "Genes up-regulated in DLD-1 cells (colon cancer) in response to hypoxia; might not be direct targets of HIF1A [GeneID=3091].", "MODY_HIPPOCAMPUS_NEONATAL": "Genes highly expressed in the neonatal hippocampus (clusters 4 and 8).", "MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP": "Genes commonly up-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313] [GeneID=2078].", "MODY_HIPPOCAMPUS_POSTNATAL": "Genes up-regulated in hyppocampus at late postnatal stages (clusters 11 and 15).", "MODY_HIPPOCAMPUS_PRENATAL": "Genes highly expressed in prenatal hippocampus (cluster 1).", "MOHANKUMAR_HOXA1_TARGETS_DN": "Down-regulated in MCF7 cells (breast cancer) by HOXA1 [GeneID=3198].", "MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_UP": "Genes commonly up-regulated in SK-N-BE cells (neuroblastoma) after RNAi knockdown of CCND1 and CDK4 [GeneID=595;1019].", "MONTERO_THYROID_CANCER_POOR_SURVIVAL_UP": "Up-regulated genes predicting poor survival of patients with thyroid carcinoma.", "MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_DN": "Genes commonly down-regulated in SK-N-BE cells (neuroblastoma) after RNAi knockdown of CCND1 and CDK4 [GeneID=595;1019].", "MONTERO_THYROID_CANCER_POOR_SURVIVAL_DN": "Down-regulated genes predicting poor survival of patients with thyroid carcinoma.", "MOHANKUMAR_HOXA1_TARGETS_UP": "Up-regulated in MCF7 cells (breast cancer) by HOXA1 [GeneID=3198].", "MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN": "The postradiation tumor escape signature: genes down-regulated in tumors from irradiated stroma vs those from non-irradiated stroma.", "MOOTHA_GLUCONEOGENESIS": "Genes involved in gluconeogenesis; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.", "MOOTHA_FFA_OXYDATION": "Genes involved in free fatty acid oxidation; based on literature and sequence annotation resources and coverted to Affymetrix HG-U133A probe sets.", "MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP": "The postradiation tumor escape signature: genes up-regulated in tumors from irradiated stroma vs those from non-irradiated stroma.", "MOOTHA_GLYCOGEN_METABOLISM": "Genes involved in glycogen metabolism; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.", "MOOTHA_GLYCOLYSIS": "Genes involved in glycolysis; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.", "MOOTHA_PYR": "Genes involved in pyruvate metabolism; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.", "MOOTHA_ROS": "Reactive oxidative species (ROS) genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.", "MOOTHA_TCA": "Tricarboxylic acid related genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.", "MOOTHA_HUMAN_MITODB_6_2002": "Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.", "MOOTHA_PGC": "Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [GeneID=10891] off an adenoviral vector.", "MOOTHA_MITOCHONDRIA": "Mitochondrial genes", "MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN": "Genes down-regulated in normal bone marrow plasma cells (BMPC) compared to polyclonal plasmablasts (PPC) that also distinguished multiple myeloma (MM) samples by expression of levels of TACI [GeneID=23495].", "MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_UP": "Genes up-regulated in normal bone marrow plasma cells (BMPC) compared to polyclonal plasmablasts (PPC) that also distinguished multiple myeloma (MM) samples by expression of levels of TACI (TNFRSF13B) [GeneID=23495].", "MOOTHA_VOXPHOS": "Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.", "MOREIRA_RESPONSE_TO_TSA_DN": "Down-regulated in CD4+ [GeneID=920] T lymphocytes after 4 h treatment with 100 nM TSA [PubChem=5562].", "MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN": "Down-regulated genes distinguishing in multiple myeloma (MM) samples with lower expression of TACI [GeneID=23495].", "MOREIRA_RESPONSE_TO_TSA_UP": "Up-regulated in CD4+ [GeneID=920] T lymphocytes after 4 h treatment with 100 nM TSA [PubChem=5562].", "MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP": "Up-regulated genes distinguishing in multiple myeloma (MM) samples with higher expression of TACI [GeneID=23495].", "MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_DN": "Genes correlated with the late tumor onset in the Emu-myc transgenic mouse lymphoma model.", "MORI_IMMATURE_B_LYMPHOCYTE_DN": "Down-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the immature B stage.", "MORI_IMMATURE_B_LYMPHOCYTE_UP": "Up-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the immature B stage.", "MORI_LARGE_PRE_BII_LYMPHOCYTE_DN": "Down-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the  Large Pre-BII stage.", "MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_UP": "Genes correlated with the early tumor onset in the Emu-myc transgenic mouse lymphoma model.", "MORI_LARGE_PRE_BII_LYMPHOCYTE_UP": "Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the  Large Pre-BII stage.", "MORI_MATURE_B_LYMPHOCYTE_DN": "Down-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the  mature B", "MORI_MATURE_B_LYMPHOCYTE_UP": "Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the  mature B", "MORI_PLASMA_CELL_DN": "Down-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: plasma cell.", "MORI_PLASMA_CELL_UP": "Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: plasma cell.", "MOROSETTI_FACIOSCAPULOHUMERAL_MUSCULAR_DISTROPHY_DN": "Genes down-regulated in FSHD (facioscapulohumeral muscular dystrophy) mesoangioblasts.", "MORI_SMALL_PRE_BII_LYMPHOCYTE_DN": "Down-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Small Pre-BII stage.", "MORI_PRE_BI_LYMPHOCYTE_DN": "Down-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Pre-BI stage.", "MORI_PRE_BI_LYMPHOCYTE_UP": "Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Pre-BI stage.", "MORI_SMALL_PRE_BII_LYMPHOCYTE_UP": "Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Small Pre-BII stage.", "MOROSETTI_FACIOSCAPULOHUMERAL_MUSCULAR_DISTROPHY_UP": "Genes up-regulated in FSHD (facioscapulohumeral muscular dystrophy) mesoangioblasts.", "MOSERLE_IFNA_RESPONSE": "Top 50 genes up-regulated in ovarian cancer progenitor cells (also known as side population, SP, cells) in response to interferon alpha (IFNA).", "MOTAMED_RESPONSE_TO_ANDROGEN_DN": "Genes down-regulated in ovarian epithelial cells in response to dihydrotestosterone (DHT) [PubChem=10635].", "MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_UP": "Up-regulated target genes shared by acute myeloid leukemia (AML) translocation products PML RARA [GeneID=5371;5914], AML1 ETO [GeneID=861;862], and PLZF RARA [GeneID=5914;7704].", "MOTAMED_RESPONSE_TO_ANDROGEN_UP": "Genes up-regulated in ovarian epithelial cells in response to dihydrotestosterone (DHT) [PubChem=10635].", "MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_DN": "Down-regulated target genes shared by acute myeloid leukemia (AML) translocation products PML RARA [GeneID=5371;5914], AML1 ETO [GeneID=861;862], and PLZF RARA [GeneID=5914;7704].", "MULLIGAN_NTF3_SIGNALING_VIA_INSR_AND_IGF1R_DN": "Genes similarly down-regulated in 3T3-L1 cells (fibroblasts able to differentiate to adipocytes) upon stimulation of INSR or IGFR1 by NTF3 [GeneID=3643;3480;4908].", "MUELLER_METHYLATED_IN_GLIOBLASTOMA": "Genes up-regulated in short-term cultured glioblastomas after azacitidine [PubChem=9444] treatment.", "MULLIGAN_NTF3_SIGNALING_VIA_INSR_AND_IGF1R_UP": "Genes similarly up-regulated in 3T3-L1 cells (fibroblasts able to differentiate to adipocytes) upon stimulation of INSR or IGFR1 by NTF3 [GeneID=3643;3480;4908].", "MUELLER_PLURINET": "Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells).", "MULLIGHAN_MLL_SIGNATURE_1_DN": "The 'MLL signature 1': genes down-regulated in pediatric AML (acute myeloid leukemia) with rearranged MLL [GeneID=4297] compared to all AML cases with the intact gene.", "MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN": "The 'NPM1-mutated signature 2': genes down-regulated in pediatric AML (acute myeloid leukemia) samples with mutated NPM1 [GeneID=4869] compared to the AML cases with the intact gene and without recurring cytogenetic anomalities or M7 phenotype.", "MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN": "The 'NPM1-mutated signature 1': genes down-regulated in pediatric AML (acute myeloid leukemia) samples with mutated NPM1 [GeneID=4869] compared to all AML cases with the intact gene.", "MULLIGHAN_MLL_SIGNATURE_1_UP": "The 'MLL signature 1': genes up-regulated in pediatric AML (acute myeloid leukemia) with rearranged MLL [GeneID=4297] compared to all AML cases with the intact gene.", "MULLIGHAN_MLL_SIGNATURE_2_DN": "The 'MLL signature 2': genes down-regulated in pediatric AML (acute myeloid leukemia) with rearranged MLL [GeneID=4297] compared to the AML cases with intact MLL and NPM1 [GeneID=4869].", "MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP": "The 'NPM1-mutated signature 2': genes up-regulated in pediatric AML (acute myeloid leukemia) samples with mutated NPM1 [GeneID=4869] compared to the AML cases with the intact gene and without recurring cytogenetic anomalities or M7 phenotype.", "MUNSHI_MULTIPLE_MYELOMA_DN": "Genes down-regulated in multiple myeloma (MM) compared to normal plasma cells from the patient's identical twin.", "MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP": "The 'NPM1-mutated signature 1': genes up-regulated in pediatric AML (acute myeloid leukemia) samples with mutated NPM1 [GeneID=4869] compared to all AML cases with the intact gene.", "MULLIGHAN_MLL_SIGNATURE_2_UP": "The 'MLL signature 2': genes up-regulated in pediatric AML (acute myeloid leukemia) with rearranged MLL [GeneID=4297] compared to the AML cases with intact MLL and NPM1 [GeneID=4869].", "MULLIGHAN_NPM1_SIGNATURE_3_DN": "The 'NPM1 signature 3': genes down-regulated in pediatric AML (acute myeloid leukemia) with mutated NPM1 [GeneID=4869] compared to the AML cases with intact NPM1 and MLL [GeneID=4297].", "MULLIGHAN_NPM1_SIGNATURE_3_UP": "The 'NPM1 signature 3': genes up-regulated in pediatric AML (acute myeloid leukemia) with mutated NPM1 [GeneID=4869] compared to the AML cases with intact NPM1 and MLL [GeneID=4297].", "MURAKAMI_UV_RESPONSE_1HR_UP": "Genes up-regulated in primary keratinocytes at 1 h after UVB irradiation.", "MUNSHI_MULTIPLE_MYELOMA_UP": "Genes up-regulated in multiple myeloma (MM) compared to normal plasma cells from the patient's identical twin.", "MURAKAMI_UV_RESPONSE_1HR_DN": "Genes down-regulated in primary keratinocytes at 1 h after UVB irradiation.", "MURATA_VIRULENCE_OF_H_PILORI": "Selected genes up-regulated in WT-A10 cells (gastric epithelium) expressing the H. pilori virulence gene CagA.", "MURAKAMI_UV_RESPONSE_6HR_DN": "Genes down-regulated in primary keratinocytes at 6 h after UVB irradiation.", "MURAKAMI_UV_RESPONSE_24HR": "Genes down-regulated in primary keratinocytes at 24 h after UVB irradiation.", "MURAKAMI_UV_RESPONSE_6HR_UP": "Genes up-regulated in primary keratinocytes at 6 h after UVB irradiation.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_12": "Amplification hot spot 12: colocolized fragile sites and cancer genes in the 17q11.1-q21; 17q25 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_1": "Amplification hot spot 1: colocolized fragile sites and cancer genes in the Xp22.3-p11.1 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_13": "Amplification hot spot 13: colocolized fragile sites and cancer genes in the Xq12-q28 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_15": "Amplification hot spot 15: colocalized fragile sites and cancer genes in the 6p25-p11.1 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_16": "Amplification hot spot 16: colocolized fragile sites and cancer genes in the 8q11.1-q24.3 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_17": "Amplification hot spot 17: colocalized fragile sites and cancer genes in the 1q11-q44 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_18": "Amplification hot spot 18: colocolized fragile sites and cancer genes in the 18q11.2-q23 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_2": "Amplification hot spot 2: colocolized fragile sites and cancer genes in the 12p13-p11.1 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_23": "Amplification hot spot 23: colocolized fragile sites and cancer genes in the 11q12-q25 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_21": "Amplification hot spot 21: colocolized fragile sites and cancer genes in the 12q13-q21 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_25": "Amplification hot spot 25: colocalized fragile sites and cancer genes in the 2q13-q36 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_24": "Amplification hot spot 24: colocalized fragile sites and cancer genes in the 1q21-q24 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_22": "Amplification hot spot 22: colocolized fragile sites and cancer genes in the 22q11.1-q13s region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_29": "Amplification hot spot 29: colocolized fragile sites and cancer genes in the 7p22-p13 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_27": "Amplification hot spot 27: colocalized fragile sites and cancer genes in the 5p15.3-p15.1; 5p12-q35 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_30": "Amplification hot spot 30: colocolized fragile sites and cancer genes in the 12q21-q24.3 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_5": "Amplification hot spot 5: colocolized fragile sites and cancer genes in the 17q22-q25 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_6": "Amplification hot spot 6: colocolized fragile sites and cancer genes in the 17p13-p11.1 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_8": "Amplification hot spot 8: colocolized fragile sites and cancer genes in the 9q11-34 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_7": "Amplification hot spot 7: colocalized fragile sites and cancer genes in the 3q26.3-q29 region.", "MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_9": "Amplification hot spot 9: colocolized fragile sites and cancer genes in the 8p23-q12; 8q23 region.", "NABA_BASEMENT_MEMBRANES": "Genes encoding structural components of basement membranes", "NABA_COLLAGENS": "Genes encoding collagen proteins", "NABA_ECM_AFFILIATED": "Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins", "NABA_CORE_MATRISOME": "Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans", "NABA_ECM_GLYCOPROTEINS": "Genes encoding structural ECM glycoproteins", "NABA_MATRISOME_HGSOC_OMENTAL_METASTASIS": "Matrisome proteins detected in significantly different abundance in omentum metastases from high grade serous ovarian cancer (HGSOC) compared to normal omentum.", "NABA_MATRISOME_HIGHLY_METASTATIC_BREAST_CANCER": "Matrisome proteins exclusively detected in highly metastatic breast cancer human-to-mouse xenografts (MDA-MB-231_LM2) in comparison to poorly metastatic breast cancer human-to-mouse xenografts (MDA-MB-231).", "NABA_ECM_REGULATORS": "Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix", "NABA_MATRISOME": "Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins", "NABA_MATRISOME_ASSOCIATED": "Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors", "NABA_MATRISOME_HIGHLY_METASTATIC_BREAST_CANCER_TUMOR_CELL_DERIVED": "Tumor-cell-derived matrisome proteins exclusively detected in highly metastatic breast cancer human-to-mouse xenografts (MDA-MB-231_LM2) in comparison to poorly metastatic breast cancer human-to-mouse xenografts (MDA-MB-231).", "NABA_MATRISOME_HIGHLY_METASTATIC_MELANOMA": "Matrisome proteins exclusively detected in highly metastatic melanoma human-to-mouse xenografts (A375_MA2) in comparison to poorly metastatic melanoma human-to-mouse xenografts (A375).", "NABA_MATRISOME_MULTIPLE_MYELOMA": "Matrisome proteins detected in newly-diagnosed multiple myeloma (MM) patient bone marrow (BM) compared to MGUS and relapsed MM-BM.", "NABA_MATRISOME_HIGHLY_METASTATIC_MELANOMA_TUMOR_CELL_DERIVED": "Tumor-cell-derived matrisome proteins exclusively detected in highly metastatic melanoma human-to-mouse xenografts (A375_MA2) in comparison to poorly metastatic melanoma human-to-mouse xenografts (A375).", "NABA_MATRISOME_METASTATIC_COLORECTAL_LIVER_METASTASIS": "Matrisome proteins found differentially expressed in secondary colorectal liver metastatases in comparison to normal colon and normal liver.", "NABA_MATRISOME_POORLY_METASTATIC_BREAST_CANCER": "Matrisome proteins exclusievly detected in poorly metastatic breast cancer human-to-mouse xenografts (MDA-MB-231) in comparison to highly metastatic breast cancer human-to-mouse xenografts (MDA-MB-231_LM2).", "NABA_MATRISOME_POORLY_METASTATIC_BREAST_CANCER_TUMOR_CELL_DERIVED": "Tumor-cell-derived matrisome proteins exclusively detected in poorly metastatic breast cancer human-to-mouse xenografts (MDA-MB-231) in comparison to highly metastatic breast cancer human-to-mouse xenografts (MDA-MB-231_LM2)", "NABA_MATRISOME_POORLY_METASTATIC_MELANOMA": "Matrisome proteins exclusively detected in poorly metastatic melanoma human-to-mouse xenografts (A375) in comparison to highly metastatic melanoma human-to-mouse xenografts (A375_MA2).", "NABA_MATRISOME_POORLY_METASTATIC_MELANOMA_TUMOR_CELL_DERIVED": "Tumor-derived matrisome proteins exclusively detected in poorly metastatic melanoma human-to-mouse xenografts (A375) in comparison to highly metastatic melanoma human-to-mouse xenografts (A375_MA2).", "NABA_MATRISOME_PRIMARY_METASTATIC_COLORECTAL_TUMOR": "Matrisome proteins found differentially expressed in primary metastatic colon tumors in comparison to normal colon and normal liver.", "NADELLA_PRKAR1A_TARGETS_DN": "Epithelial and mesenchymal markers down-regulated in MEF cells (embryonic fibroblasts) after knockout of PRKAR1A [GeneID=5573].", "NADELLA_PRKAR1A_TARGETS_UP": "Epithelial and mesenchymal markers up-regulated in MEF cells (embryonic fibroblasts) after knockout of PRKAR1A [GeneID=5573].", "NABA_PROTEOGLYCANS": "Genes encoding proteoglycans", "NADERI_BREAST_CANCER_PROGNOSIS_DN": "Down-regulated genes in the breast cancer prognostic signature of 70 genes that significantly correlated with survival.", "NABA_SECRETED_FACTORS": "Genes encoding secreted soluble factors", "NADERI_BREAST_CANCER_PROGNOSIS_UP": "Up-regulated genes in the breast cancer prognostic signature of 70 genes that significantly correlated with survival.", "NADLER_HYPERGLYCEMIA_AT_OBESITY": "Genes correlated with the development of hyperglycemia in obese mice.", "NADLER_OBESITY_DN": "Genes down-regulated in adipose tissue from obese mouse strains compared to the lean ones.", "NAGY_PCAF_COMPONENTS_HUMAN": "Composition of the 2 MDa human PCAF complex.", "NADLER_OBESITY_UP": "Genes up-regulated in adipose tissue from obese mouse strains compared to the lean ones.", "NAGASHIMA_NRG1_SIGNALING_DN": "Genes down-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084].", "NAGY_STAGA_COMPONENTS_HUMAN": "Composition of the 2 MDa human STAGA complex containing KAT2A [GeneID=2648].", "NAGASHIMA_EGF_SIGNALING_UP": "Genes up-regulated in MCF7 cells (breast cancer) after stimulation with EGF [GeneID=1950].", "NAKAJIMA_EOSINOPHIL": "Top 30 increased eosinophil specific transcripts.", "NAGY_TFTC_COMPONENTS_HUMAN": "Composition of the 2 MDa human TFTC complex containing KAT2A [GeneID=2648].", "NAISHIRO_CTNNB1_TARGETS_WITH_LEF1_MOTIF": "Genes regulated by CTNNB1 [GeneID=1499] and whose promoters contain binding sites for LEF1 [GeneID=51176].", "NAGASHIMA_NRG1_SIGNALING_UP": "Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084].", "NAKAMURA_ALVEOLAR_EPITHELIUM": "Differentiation markers for normal alveolar epithelium cells.", "NAKAMURA_ADIPOGENESIS_EARLY_DN": "Genes down-regulated in mesenchymal stem cells during early phase of adipogenesis, defined as days 1 to 5 of culturing with adipogenic hormones.", "NAKAJIMA_MAST_CELL": "Top 50 most-increased mast cell specific genes.", "NAKAMURA_ADIPOGENESIS_EARLY_UP": "Genes up-regulated in mesenchymal stem cells during early phase of adipogenesis, defined as days 1 to 5 of culturing with adipogenic hormones.", "NAKAMURA_LUNG_CANCER": "Genes up-regulated in lung adenocarcinoma cell lines and not expressed in non-cancerous lung epithelial cells.", "NAKAMURA_ADIPOGENESIS_LATE_DN": "Genes down-regulated in mesenchymal stem cells during late phase of adipogenesis, defined as days 7 to 14 of culturing with adipogenic hormones.", "NAKAMURA_ADIPOGENESIS_LATE_UP": "Genes up-regulated in mesenchymal stem cells during late phase of adipogenesis, defined as days 7 to 14 of culturing with adipogenic hormones.", "NAKAMURA_BRONCHIAL_AND_BRONCHIOLAR_EPITHELIA": "Differentiation markers for normal bronchiolar and bronchial epithelial cells.", "NAKAMURA_CANCER_MICROENVIRONMENT_DN": "Genes down-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro.", "NAKAMURA_CANCER_MICROENVIRONMENT_UP": "Genes up-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro.", "NAKAMURA_LUNG_CANCER_DIFFERENTIATION_MARKERS": "14 candidate differentiation markers in lung adenocarcinoma cells, noncancerous lung cells and peripheral blood cells.", "NAKAMURA_METASTASIS": "Genes up-regulated in highly metastatic pancreatic cancer cells.", "NAKAMURA_METASTASIS_MODEL_DN": "Bottom genes down-regulated in subcutaneous tumors from highly metastatic pancreatic cancer cells.", "NAKAMURA_METASTASIS_MODEL_UP": "Top genes up-regulated in orthotopic tumors from highly metastatic pancreatic cancer cells.", "NAKAYAMA_FRA2_TARGETS": "Genes down-regulated in ST1 cells (adult T-cell leukemia, ATL) after knockdown of FRA2 [GeneID=2355] by RNAi.", "NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_DN": "Top 100 probe sets contrubuting to the negative side of the 2nd principal component; associated with adipocytic differentiation.", "NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN": "Top 100 probe sets contrubuting to the negative side of the 1st principal component; predominantly associated with synovial sarcoma and myxoid/round cell liposarcoma samples.", "NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP": "Up-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone.", "NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP": "Top 100 probe sets contrubuting to the positive side of the 1st principal component; predominantly associated with spindle cell and pleomorphic sarcoma samples.", "NAM_FXYD5_TARGETS_DN": "Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of FXYD5 [GeneID=53827] by RNAi.", "NATSUME_RESPONSE_TO_INTERFERON_BETA_DN": "Genes down-regulated in T98 cells (glioma) 48 h after treatment with interferon beta.", "NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN": "Down-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone.", "NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP": "Top 100 probe sets contrubuting to the positive side of the 2nd principal component; associated with adipocytic differentiation.", "NEBEN_AML_WITH_FLT3_OR_NRAS_DN": "Genes down-regulated in acute myeloid leukemia (AML) samples with constitutively activated FLT3 [GeneID=2322] or with activating point mutations within NRAS [GeneID=4893].", "NATSUME_RESPONSE_TO_INTERFERON_BETA_UP": "Genes up-regulated in T98 cells (glioma) 48 h after treatment with interferon beta.", "NEBEN_AML_WITH_FLT3_OR_NRAS_UP": "Genes up-regulated in acute myeloid leukemia (AML) samples with constitutively activated FLT3 [GeneID=2322] or with activating point mutations within NRAS [GeneID=4893].", "NELSON_RESPONSE_TO_ANDROGEN_DN": "Genes down-regulated in LNCaP cells (prostate cancer) in response to synthetic androgen R1881 [PubChem=13766].", "NELSON_RESPONSE_TO_ANDROGEN_UP": "Genes up-regulated in LNCaP cells (prostate cancer) in response to synthetic androgen R1881 [PubChem=13766].", "NEMETH_INFLAMMATORY_RESPONSE_LPS_DN": "Genes down-regulated in RAW 264.7 cells (macrophage) 3 hr after stimulation with bacterial lipopolysaccharide (LPS).", "NEMETH_INFLAMMATORY_RESPONSE_LPS_UP": "Genes up-regulated in RAW 264.7 cells (macrophage) 3 hr after stimulation with bacterial lipopolysaccharide (LPS).", "NEWMAN_ERCC6_TARGETS_UP": "Genes up-regulated in Cockayne syndrome fibroblasts rescued by expression of ERCC6 [GeneID=2074] off a plasmid vector.", "NEWMAN_ERCC6_TARGETS_DN": "Genes down-regulated in Cockayne syndrome fibroblasts rescued by expression of ERCC6 [GeneID=2074] off a plasmid vector.", "NGO_MALIGNANT_GLIOMA_1P_LOH": "Proteins with reduced expression in mulignant glioma cell line (A172) which bears loss of heterozygosity (LOH) in the 1p region.", "NICK_RESPONSE_TO_PROC_TREATMENT_DN": "Genes down-regulated in neutrophils upon treatment with activated protein C (PROC) [GeneID=5624] of pulmonary inflammation induced by bacterial lipopolysaccharide (LPS).", "NGUYEN_NOTCH1_TARGETS_DN": "Genes down-regulated in primary keratinocytes by expression of constantly active NOTCH1 [GeneID=4851].", "NGUYEN_NOTCH1_TARGETS_UP": "Genes up-regulated in primary keratinocytes by expression of constantly active NOTCH1 [GeneID=4851].", "NICK_RESPONSE_TO_PROC_TREATMENT_UP": "Genes up-regulated in neutrophils upon treatment with activated protein C (PROC) [GeneID=5624] of pulmonary inflammation induced by bacterial lipopolysaccharide (LPS).", "NIKOLSKY_BREAST_CANCER_10Q22_AMPLICON": "Genes within amplicon 10q22 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_12Q13_Q21_AMPLICON": "Genes within amplicon 12q13-q21 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON": "Genes within amplicon  11q12-q14 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_12Q24_AMPLICON": "Genes within amplicon  12q24 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_15Q26_AMPLICON": "Genes within amplicon 15q26 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_14Q22_AMPLICON": "Genes within amplicon 14q22 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_17P11_AMPLICON": "Genes within amplicon 17p11 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON": "Genes within amplicon 16q24 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_19P13_AMPLICON": "Genes within amplicon 19p13 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_16P13_AMPLICON": "Genes within amplicon 16p13 identified in a study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_17Q11_Q21_AMPLICON": "Genes within amplicon 17q11-q21 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_19Q13.1_AMPLICON": "Genes within amplicon 19q13.1 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_19Q13.4_AMPLICON": "Genes within amplicon 19q13.4 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON": "Genes within amplicon 17q21-q25 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_20P13_AMPLICON": "Genes within amplicon 20p13 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_1Q21_AMPLICON": "Genes within amplicon 1q21 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_1Q32_AMPLICON": "Genes within amplicon 1q32 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_20Q11_AMPLICON": "Genes within amplicon 20q11 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_21Q22_AMPLICON": "Genes within amplicon 21q22 identified in a copy alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_22Q13_AMPLICON": "Genes within amplicon 22q13 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_5P15_AMPLICON": "Genes within amplicon 5p15 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_7P15_AMPLICON": "Genes within amplicon 7p15 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_6P24_P22_AMPLICON": "Genes within amplicon 6p24-p22 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON": "Genes within amplicon 20q12-q13 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_7P22_AMPLICON": "Genes within amplicon 7p22 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_8P12_P11_AMPLICON": "Genes within amplicon 8p12-p11 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_7Q21_Q22_AMPLICON": "Genes within amplicon 7q21-q22 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON": "Genes within amplicon 8q12-q22 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON": "Genes within amplicon 8q23-q24 identified in a copy number alterations study of 191 breast tumor samples.", "NIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER": "Genes both mutated and amplified in a panel of 191 breast tumor samples.", "NOJIMA_SFRP2_TARGETS_UP": "Cellular proliferation, growth, apoptosis and Wnt signaling genes up-regulated in SNU638 cells (gastric cancer) by overexpression of SFRP2 [GeneID=6423] off a plasmid vector.", "NOJIMA_SFRP2_TARGETS_DN": "Cellular proliferation, growth, apoptosis and Wnt signaling genes down-regulated in SNU638 cells (gastric cancer) by overexpression of SFRP2 [GeneID=6423] off a plasmid vector.", "NIKOLSKY_OVERCONNECTED_IN_BREAST_CANCER": "Overconnected mutated transcription factors regulating genes within the breast cancer amplicome.", "NOUSHMEHR_GBM_GERMLINE_MUTATED": "Genes with significantl germline mutation differences in proneural G-CIMP (a CpG island methylator phenotype) GBM (glyoblastoma multiforme) tumors.", "NOUSHMEHR_GBM_SOMATIC_MUTATED": "Genes showing significantly elevated somatic mutation frequencies in proneural G-CIMP (a CpG island methylator phenotype) GBM (glyoblastoma multiforme) tumors.", "NOUSHMEHR_GBM_SILENCED_BY_METHYLATION": "Top 50 most differentially hypermethylated and down-regulated genes in proneural G-CIMP (a CpG island methylator phenotype) GBM (glyoblastoma multiforme) tumors.", "NOURUZI_NEPC_ASCL1_TARGETS": "Genes bound by ASCL1 in prostate cancer cell lines, and up-regulated in ASCL1 positive patient-driven xenografts.", "NUMATA_CSF3_SIGNALING_VIA_STAT3": "Target genes for STAT3 [GeneID=20848] in CSF3 [GeneID=12985] signaling during myeloblast differentiation to neutrophils.", "NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_DN": "Genes down-regulated in K562 cells (bone marrow) after treatment with dasatinib [PubChem=3062316] or imatinib [PubChem=5291].", "NOUZOVA_METHYLATED_IN_APL": "Genes whose CpG islands are hyper-methylated in the NB4 cell line (APL, acute promyelocytic leukemia) compared to PBMC (normal peripheral peripheral blood mononuclear cells).", "NOUZOVA_TRETINOIN_AND_H4_ACETYLATION": "Genes whose CpG islands showed greatly increased histone H4 acetylation in NB4 cells (acute promyelocytic leukemia, APL) upon treatment with tretinoin [PubChem=444795].", "NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_UP": "Genes up-regulated in K562 cells (bone marrow) after treatment with dasatinib [PubChem=3062316] or imatinib [PubChem=5291].", "NUTT_GBM_VS_AO_GLIOMA_DN": "Top 50 marker genes for anaplastic oligodendroglioma (AO), a class of high grade glioma.", "NUTT_GBM_VS_AO_GLIOMA_UP": "Top 50 marker genes for glioblastoma multiforme (GBM), a class of high grade glioma.", "ODONNELL_METASTASIS_DN": "Down-regulated genes in the signature set for lymph node metastasis in head and neck squamous cell carcinoma (HNSCC).", "NUYTTEN_EZH2_TARGETS_DN": "Genes down-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [GeneID=2146] by RNAi.", "ODONNELL_METASTASIS_UP": "Up-regulated genes in the signature set for lymph node metastasis in head and neck squamous cell carcinoma (HNSCC).", "NUYTTEN_NIPP1_TARGETS_DN": "Genes down-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [GeneID=5511] by RNAi.", "ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN": "Genes up-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) by MYC [GeneID=4609] and down-regulated by RNAi knockdown of TFRC [GeneID=7037].", "ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP": "Genes down-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) by MYC [GeneID=4609] and up-regulated by RNAi knockdown of TFRC [GeneID=7037].", "NUYTTEN_EZH2_TARGETS_UP": "Genes up-regulated in PC3 cells (prostate cancer) after knockdown of EZH2 [GeneID=2146] by RNAi.", "OHASHI_AURKA_TARGETS": "Candidate substrate proteins of AURKA [GeneID=6790].", "ODONNELL_TFRC_TARGETS_DN": "Genes down-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) upon knockdown of TFRC [GeneID=7037] by RNAi.", "NUYTTEN_NIPP1_TARGETS_UP": "Genes up-regulated in PC3 cells (prostate cancer) after knockdown of NIPP1 [GeneID=5511] by RNAi.", "OHASHI_AURKB_TARGETS": "Candidate substrate proteins of AURKB [GeneID=9212].", "ODONNELL_TFRC_TARGETS_UP": "Genes up-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) upon knockdown of TFRC [GeneID=7037] by RNAi.", "OHGUCHI_LIVER_HNF4A_TARGETS_DN": "Genes down-regulated in liver samples of liver-specific knockout of HNF4A [GeneID=3172].", "OHM_EMBRYONIC_CARCINOMA_DN": "Genes with low to medium basal transcription state in undifferentiated embryonic carcinoma cells.", "OHGUCHI_LIVER_HNF4A_TARGETS_UP": "Genes up-regulated in liver samples of liver-specific knockout of HNF4A [GeneID=3172].", "OHM_EMBRYONIC_CARCINOMA_UP": "Genes with a high basal transcription state in undifferentiated embryonic carcinoma cells.", "OHM_METHYLATED_IN_ADULT_CANCERS": "Genes showing frequent DNA methylation and which are silenced in adult cancers but remain unmethylated in embryonic carcinoma and embryonic stem (ES) cells.", "OKAWA_NEUROBLASTOMA_1P36_31_DELETION": "Genes in the smallest region of deletion (SRD) in 1p36.3 area in neuroblastoma samples.", "OISHI_CHOLANGIOMA_STEM_CELL_LIKE_DN": "Genes under-expressed in stem cell-like cholangiocellular carcinoma", "OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP": "Genes over-expressed in stem cell-like cholangiocellular carcinoma.", "OKUMURA_INFLAMMATORY_RESPONSE_LPS": "Genes up-regulated in mast cells (MC) after stimulation with a bacterial lipopolysaccharide (LPS).", "OLSSON_E2F3_TARGETS_UP": "Genes up-regulated in the 5637 cell line (bladder cancer) after knockdown of E2F3 [GeneID=1871] by RNAi.", "OLSSON_E2F3_TARGETS_DN": "Genes down-regulated in the 5637 cell line (bladder cancer) after knockdown of E2F3 [GeneID=1871] by RNAi.", "ONDER_CDH1_SIGNALING_VIA_CTNNB1": "Genes changed in HMLE cells (mmortalized nontransformed mammary epithelium) after RNAi knockdown of both CDH1 and CTNNB1 [GeneID=999;1499], compared to the knockdown of CDH1 alone.", "ONDER_CDH1_TARGETS_1_DN": "Genes down-regulated in HMLE cells (mmortalized nontransformed mammary epithelial) by expression of a dominant-negative form of E-cadhedrin (CDH1) [GeneID=999].", "ONDER_CDH1_TARGETS_1_UP": "Genes up-regulated in HMLE cells (mmortalized nontransformed mammary epithelial) by expression of a dominant-negative form of E-cadhedrin (CDH1) [GeneID=999].", "ONGUSAHA_BRCA1_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) lacking TP53 and BRCA1 [GeneID=7157;672] by expression of BRCA1.", "ONDER_CDH1_TARGETS_2_DN": "Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi.", "ONGUSAHA_BRCA1_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) lacking TP53 and BRCA1 [GeneID=7157;672] by expression of BRCA1.", "ONDER_CDH1_TARGETS_3_UP": "Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelial) cells after loss of function of E-cadhedrin (CDH1) [GeneID=999], which was achieved either by RNAi knockdown or by expression of a dominan-negative form of CDH1.", "ONDER_CDH1_TARGETS_3_DN": "Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelial) cells after loss of function of E-cadhedrin (CDH1) [GeneID=999], which was achieved either by RNAi knockdown or by expression of a dominan-negative form of CDH1.", "ONDER_CDH1_TARGETS_2_UP": "Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi.", "ONGUSAHA_TP53_TARGETS": "Genes up-regulated in MEF cells (embryonic fibroblast) lacking TP53 and BRCA1 [GeneID=7157;672] by expression of TP53; most genes are further up-regulated by simultaneous expression of BRCA1.", "ONO_AML1_TARGETS_DN": "Genes down-regulated in CD4+ [GeneID=920] T lymphocytes by expression of AML1 [GeneID=861] off a viral vector.", "ONO_AML1_TARGETS_UP": "Genes up-regulated in CD4+ [GeneID=920] T lymphocytes by expression of AML1 [GeneID=861] off a viral vector.", "ONO_FOXP3_TARGETS_DN": "Genes down-regulated in CD4+ [GeneID=920] T lymphocytes transduced with FOXP3 [GeneID=50943].", "OSADA_ASCL1_TARGETS_DN": "Genes down-regulated in A549 cells (lung cancer) upon expression of ASCL1 [GeneID=429] off a viral vector.", "ONKEN_UVEAL_MELANOMA_UP": "Genes up-regulated in uveal melanoma: class 2 vs class 1 tumors.", "ONKEN_UVEAL_MELANOMA_DN": "Genes down-regulated in uveal melanoma: class 2 vs class 1 tumors.", "ONO_FOXP3_TARGETS_UP": "Genes up-regulated in CD4+ [GeneID=920] T lymphocytes transduced with FOXP3 [GeneID=50943].", "OSADA_ASCL1_TARGETS_UP": "Genes up-regulated in A549 cells (lung cancer) upon expression of ASCL1 [GeneID=429] off a viral vector.", "OSAWA_TNF_TARGETS": "Genes up-regulated in Hc cells (normal hepatocyte) by  TNF [GeneID=7124].", "OSMAN_BLADDER_CANCER_UP": "Genes up-regulated in blood samples from bladder cancer patients.", "OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN": "Genes down-regulated in epithelial ovarian cancer (EOC) biopsies: invasive (TOV) vs low malignant potential (LMP) tumors.", "OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN": "Genes down-regulated in hematopoietic stem cells (HSC, CD34+ [GeneID=947]) cultured in a three-dimentional collagen gel compared to the cells grown in suspension.", "OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_DN": "Genes down-regulated in pirmary cultures of epithelial ovarian cancer (EOC): invasive (TOV) vs low malignant potential (LMP) tumors.", "OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP": "Genes up-regulated in hematopoietic stem cells (HSC, CD34+ [GeneID=947]) cultured in a three-dimentional collagen gel compared to the cells grown in suspension.", "OSMAN_BLADDER_CANCER_DN": "Genes down-regulated in blood samples from bladder cancer patients.", "OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_UP": "Genes up-regulated in pirmary cultures of epithelial ovarian cancer (EOC): invasive (TOV) vs low malignant potential (LMP) tumors.", "OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP": "Genes up-regulated in epithelial ovarian cancer (EOC) biopsies: invasive (TOV) vs low malignant potential (LMP) tumors.", "OUILLETTE_CLL_13Q14_DELETION_UP": "Genes up-regulated in chronic lymphocytic leukemia (CLL) samples bearing deletions in the 13q14 region.", "OUILLETTE_CLL_13Q14_DELETION_DN": "Genes down-regulated in chronic lymphocytic leukemia (CLL) samples bearing deletions in the 13q14 region.", "OUYANG_PROSTATE_CANCER_MARKERS": "Mouse orthologs of human prostate cancer tumor markers which were deregulated in mice heterozygotic for both NKX3.1 and PTEN [GeneID=4824;5728].", "OUYANG_PROSTATE_CANCER_PROGRESSION_DN": "Genes down-regulated during prostate cancer progression in mice heterozygotic for both NKX3.1 and PTEN [GeneID=4824;5728].", "OUYANG_PROSTATE_CANCER_PROGRESSION_UP": "Genes up-regulated during prostate cancer progression in mice heterozygotic for both NKX3.1 and PTEN [GeneID=4824;5728].", "OZANNE_AP1_TARGETS_UP": "Cancer motility and invasion genes up-regulated by the AP-1 transcription factor.", "PACHER_TARGETS_OF_IGF1_AND_IGF2_UP": "Genes up-regulated in MCF7 cells (breast cancer) by IGF1 and IGF2 [GeneID=3479;3481].", "OZEN_MIR125B1_TARGETS": "Potential targets of MIR125B1 [GeneID=406911] microRNA which are up-regulated in prostate cancer.", "PALOMERO_GSI_SENSITIVITY_DN": "Down-regulated genes associated with sensitivity and resistance to gamma-secretase (GSI) in T-cell acute lymphoblastic leukemia (T-ALL) cell lines.", "PALOMERO_GSI_SENSITIVITY_UP": "Up-regulated genes associated with sensitivity and resistance to gamma-secretase (GSI) in T-cell acute lymphoblastic leukemia (T-ALL) cell lines.", "PAL_PRMT5_TARGETS_DN": "Genes down-regulated in NIH-3T3 cells (fibroblast) after knockdown of PRMT5 [GeneID=10419] by RNAi.", "PAL_PRMT5_TARGETS_UP": "Genes up-regulated in NIH-3T3 cells (fibroblast) after knockdown of PRMT5 [GeneID=10419] by RNAi.", "PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_DN": "Genes down-regulated in unstable ateroslerotic plaques compared to the stable ones.", "PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN": "Genes down-regulated in ovarian tumors from mouse models for the BMP SMAD signaling (gonad specific double knockout of SMAD1 and SMAD5 [GeneID=4086] [GeneID=4090]).", "PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP": "Genes up-regulated in ovarian tumors from mouse models for the BMP SMAD signaling (gonad specific double knockout of SMAD1 and SMAD5 [GeneID=4086] [GeneID=4090]).", "PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_UP": "Genes up-regulated in unstable ateroslerotic plaques compared to the stable ones.", "PARENT_MTOR_SIGNALING_DN": "Genes down-regulated in HepaRG cells (liver cancer) expressing constituvely active form of MTOR [GeneID=2475].", "PARK_APL_PATHOGENESIS_DN": "Genes down-regulated in U937 cells (acute promyelocytic leukemia, APL) expressing RARA [GeneID=5914] fused with either PML or PLZF [GeneID=5371;7704].", "PARK_APL_PATHOGENESIS_UP": "Genes up-regulated in U937 cells (acute promyelocytic leukemia, APL) expressing RARA [GeneID=5914] fused with either PML or PLZF [GeneID=5371;7704].", "PARK_HSC_AND_MULTIPOTENT_PROGENITORS": "Genes commonly expressed in long term hematopoietic stem cells (HSC) and multipotent progenitors (MPP).", "PARK_HSC_MARKERS": "Genes in a cCDNA library from hematopoietic stem cells (HSC) after subtraction of lineage-specific markers.", "PARK_HSC_VS_MULTIPOTENT_PROGENITORS_DN": "Genes down-regulated in long term hematopoietic stem cells (LT-HSC) compared to multipotent progenitor (MPP) cells.", "PARK_OSTEOBLAST_DIFFERENTIATION_BY_PHENYLAMIL_DN": "Genes down-regulated in M2-10B4 cells (osteoblast) in response to phenylamil [PubChem=4755].", "PARK_HSC_VS_MULTIPOTENT_PROGENITORS_UP": "Genes up-regulated in long term hematopoietic stem cells (LT-HSC) compared to multipotent progenitor (MPP) cells.", "PARENT_MTOR_SIGNALING_UP": "Genes up-regulated in HepaRG cells (liver cancer) expressing constituvely active form of MTOR [GeneID=2475].", "PARK_OSTEOBLAST_DIFFERENTIATION_BY_PHENYLAMIL_UP": "Genes up-regulated in M2-10B4 cells (osteoblast) in response to phenylamil [PubChem=4755].", "PARK_TRETINOIN_RESPONSE": "Genes up-regulated in U937 cells (acute promyelocytic leukemia, APL) by tretinoin (ATRA) [PubChem=444795].", "PARK_TRETINOIN_RESPONSE_AND_RARA_PLZF_FUSION": "Genes up-regulated by tretinoin (ATRA) [PubChem=444795] in U937 cells (acute promyelocytic leukemia, APL) made resistant to the drug by expression of the PLZF-RARA fusion [GeneID=7704] [GeneID=5914].", "PARK_TRETINOIN_RESPONSE_AND_PML_RARA_FUSION": "Genes up-regulated by tretinoin (ATRA) [PubChem=444795] in U937 cells (acute promyelocytic leukemia, APL) made sensitive to the drug by expression of the PML-RARA fusion [GeneID=5371;5914].", "PASINI_SUZ12_TARGETS_UP": "Genes up-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512].", "PASTURAL_RIZ1_TARGETS_UP": "Genes up-regulated in K562 (chronic myelogenous leukemia, CML) cells engineered to stably express RIZ1 [GeneID=7799].", "PASTURAL_RIZ1_TARGETS_DN": "Genes down-regulated in K562 (chronic myelogenous leukemia, CML) cells engineered to stably express RIZ1 [GeneID=7799].", "PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN": "Genes down-regulated in post-GC, BCL6 [GeneID=604] dependent B cell non-Hodgkin's lymphoma (B-NHL) vs MYC [GeneID=4609] driven pre-GC lymphoma.", "PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP": "Genes up-regulated in post-GC, BCL6 [GeneID=604] dependent B cell non-Hodgkin's lymphoma (B-NHL) vs MYC [GeneID=4609] driven pre-GC lymphoma.", "PEART_HDAC_PROLIFERATION_CLUSTER_DN": "Cell proliferation genes down-regulated by histone deacetylase (HDAC) inhibitors SAHA and depsipeptide [PubChem=5311;5352062].", "PASINI_SUZ12_TARGETS_DN": "Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512].", "PEART_HDAC_PROLIFERATION_CLUSTER_UP": "Cell proliferation genes up-regulated by histone deacetylase (HDAC) inhibitors SAHA and depsipeptide [PubChem=5311;5352062].", "PECE_MAMMARY_STEM_CELL_DN": "The '3/3 signature': genes consistently down-regulated in all three pools of normal mammary stem cells (defined by their ability to retain the dye PKH26).", "PATIL_LIVER_CANCER": "Genes up-regulated in hepatocellular carcinoma (HCC) compared to normal liver samples.", "PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_3": "Genes regulated in MCF7 cells (breast cancer) by expression of the truncated (611-CTF) form of ERBB2 [GeneID=2064] at both 15 h and 60 h time points.", "PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_1": "Genes regulated in MCF7 cells (breast cancer) by expression of full-length and truncated (611-CTF) forms of ERBB2 [GeneID=2064] at both 15 h and 60 h time points.", "PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_5": "Genes regulated in MCF7 cells (breast cancer) by expression of the truncated (611-CTF) form of ERBB2 [GeneID=2064] at 15 h time point.", "PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_4": "Genes regulated in MCF7 cells (breast cancer) by expression of the full-length and truncated (611-CTF) forms of ERBB2 [GeneID=2064] at 60 h time point.", "PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_6": "Genes regulated in MCF7 cells (breast cancer) by expression of the full-length form of ERBB2 [GeneID=2064] at 60 h time point.", "PECE_MAMMARY_STEM_CELL_UP": "The '3/3 signature': genes consistently up-regulated in all three pools of normal mammary stem cells (defined by their ability to retain the dye PKH26).", "PEDERSEN_TARGETS_OF_611CTF_ISOFORM_OF_ERBB2": "Genes up-regulated in MCF7 cells (breast cancer) more than three-fold by the truncated form 611-CTF of ERBB2 [GeneID=2064] and less than two-fold by the full-length ERBB2 [GeneID=2064].", "PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7": "Genes regulated in MCF7 cells (breast cancer) by expression of the truncated (611-CTF) form of ERBB2 [GeneID=2064] at 60 h time point.", "PEDRIOLI_MIR31_TARGETS_UP": "Genes up-regulated in primary LEC cells (lymphatic endothelum) upon overexpression of MIR31 [GeneID=407035].", "PEDRIOLI_MIR31_TARGETS_DN": "Genes down-regulated in primary LEC cells (lymphatic endothelum) upon overexpression of MIR31 [GeneID=407035].", "PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_UP": "Antigen processing and presentation genes up-regulated in JY cells (B lymphocytes) treated with TSA [PubChem=5562].", "PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN": "Antigen processing and presentation genes down-regulated in JY cells (B lymphocytes) treated with trichostatin A (TSA) [PubChem=5562].", "PEPPER_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN": "Genes down-regulated in CD38+ [GeneID=952] CLL (chronic lymphocytic leukemia) cells.", "PEPPER_CHRONIC_LYMPHOCYTIC_LEUKEMIA_UP": "Genes up-regulated in CD38+ [GeneID=952] CLL (chronic lymphocytic leukemia) cells.", "PETRETTO_BLOOD_PRESSURE_DN": "Genes that are most strongly negatively correlated with systolic blood pressure (SBP).", "PEREZ_TP53_AND_TP63_TARGETS": "Genes up-regulated in HMEC cells (primary mammary epithelium) upon expression of both of TP53 [GeneID=7157] and the transcriptionally active isoform of TP63 [GeneID=8626] off adenoviral vectors.", "PEREZ_TP63_TARGETS": "Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of the transcriptionally active isoform of TP63 [GeneID=8626] off adenoviral vector.", "PETRETTO_BLOOD_PRESSURE_UP": "Genes that are most strongly positively correlated with systolic blood pressure (SBP).", "PEREZ_TP53_TARGETS": "Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of TP53 [GeneID=7157] off adenoviral vector.", "PETRETTO_LEFT_VENTRICLE_MASS_QTL_CIS_DN": "Down-regulated cis-regulated expression quantitative loci (cis-eQTL) in the heart that were identified as candidate genes for the regulation of left ventricle mass (LVM).", "PETRETTO_CARDIAC_HYPERTROPHY": "Genes that correlated most highly with left ventricular mass (LVM) index.", "PETRETTO_HEART_MASS_QTL_CIS_DN": "Down-regulated cis-regulated expression quantitative loci (cis-eQTL) in the heart that colocalize with previously mapped cardiac mass QTLs.", "PETRETTO_HEART_MASS_QTL_CIS_UP": "Up-regulated cis-regulated expression quantitative loci (cis-eQTL) in the heart that colocalize with previously mapped cardiac mass QTLs.", "PETRETTO_LEFT_VENTRICLE_MASS_QTL_CIS_UP": "Up-regulated cis-regulated expression quantitative loci (cis-eQTL) in the heart that were identified as candidate genes for the regulation of left ventricle mass (LVM).", "PETROVA_PROX1_TARGETS_UP": "Genes specific to LEC (lymphatic endothelium cells) induced in BEC (blood endothelium cells) by expression of PROX1 [GeneID=5629] off adenovirus vector.", "PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP": "Genes up-regulated in LEC (lymphatic endothelial cells) compared to BEC (blood endothelial cells).", "PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN": "Genes down-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells).", "PETROVA_PROX1_TARGETS_DN": "Genes specific to BEC (blood endothelium cells) repressed in BEC by expression of PROX1 [GeneID=5629] off adenovirus vector.", "PHESSE_TARGETS_OF_APC_AND_MBD2_DN": "Genes down-regulated in small intestine upon loss of both APC and MBD2 [GeneID=324] [GeneID=8932].", "PHESSE_TARGETS_OF_APC_AND_MBD2_UP": "Genes up-regulated in small intestine upon loss of both APC and MBD2 [GeneID=324] [GeneID=8932].", "PHONG_TNF_TARGETS_DN": "Genes down-regulated in Calu-6 cells (lung cancer) at 1 h time point after TNF [GeneID=7124] treatment.", "PHONG_TNF_RESPONSE_VIA_P38_PARTIAL": "Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were blocked partially by p38 inhibitor LY479754.", "PHONG_TNF_RESPONSE_VIA_P38_COMPLETE": "Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were blocked completely by p38 inhibitor LY479754.", "PHONG_TNF_TARGETS_UP": "Genes up-regulated in Calu-6 cells (lung cancer) at 1 h time point after TNF [GeneID=7124] treatment.", "PHONG_TNF_RESPONSE_NOT_VIA_P38": "Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were not affected by p38 inhibitor LY479754.", "PIEPOLI_LGI1_TARGETS_UP": "Up-regulated genes in U87 cells (glioblastoma multiforme, GBM) engineered to stably express LGI1 [GeneID=9211].", "PIEPOLI_LGI1_TARGETS_DN": "Down-regulated genes in U87 cells (glioblastoma multiforme, GBM) engineered to stably express LGI1 [GeneID=9211].", "PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN": "Down-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes.", "PIONTEK_PKD1_TARGETS_DN": "Genes down-regulated during later stages of renal maturation (days P14-P16) in kidney specific knockout of PKD1 [GeneID=5310].", "PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP": "Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes.", "PIONTEK_PKD1_TARGETS_UP": "Genes up-regulated during later stages of renal maturation (days P14-P16) in kidney specific knockout of PKD1 [GeneID=5310].", "PLASARI_NFIC_TARGETS_BASAL_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) upon knockout of NFIC [GeneID=4782].", "PLASARI_NFIC_TARGETS_BASAL_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) upon knockout of NFIC [GeneID=4782].", "PILON_KLF1_TARGETS_UP": "Genes up-regulated in erythroid progenitor cells from fetal livers of E13.5 embryos with KLF1 [GeneID=10661] knockout compared to those from the wild type embryos.", "PLASARI_TGFB1_SIGNALING_VIA_NFIC_10HR_DN": "Genes down-regulated after 10 h of TGFB1 [GeneID=7040] stimulation in MEF cells (embryonic fibroblast) with  NFIC [GeneID=4782] knockout vs wild type MEFs.", "PLASARI_TGFB1_SIGNALING_VIA_NFIC_10HR_UP": "Genes up-regulated after 10 h of TGFB1 [GeneID=7040] stimulation in MEF cells (embryonic fibroblast) with  NFIC [GeneID=4782] knockout vs wild type MEFs.", "PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN": "Genes down-regulated after 1 h of TGFB1 [GeneID=7040] stimulation in MEF cells (embryonic fibroblast) with  NFIC [GeneID=4782] knockout vs wild type MEFs.", "PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_UP": "Genes up-regulated after 1 h of TGFB1 [GeneID=7040] stimulation in MEF cells (embryonic fibroblast) with  NFIC [GeneID=4782] knockout vs wild type MEFs.", "PLASARI_TGFB1_TARGETS_1HR_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 1 h.", "PLASARI_TGFB1_TARGETS_10HR_DN": "Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h.", "PLASARI_TGFB1_TARGETS_10HR_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h.", "PLASARI_TGFB1_TARGETS_1HR_UP": "Genes up-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 1 h.", "PODAR_RESPONSE_TO_ADAPHOSTIN_DN": "Down-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties.", "POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_DN": "Top down-regulated marker genes for medulloblastoma classification: desmoplastic vs classic morphology.", "PODAR_RESPONSE_TO_ADAPHOSTIN_UP": "Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties.", "POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP": "Top up-regulated marker genes for medulloblastoma classification: desmoplastic vs classic morphology.", "POMEROY_MEDULLOBLASTOMA_PROGNOSIS_DN": "Top marker genes in medulloblastoma associated with poor response to treatment (poor outcome).", "POMEROY_MEDULLOBLASTOMA_PROGNOSIS_UP": "Top marker genes in medulloblastoma associated with good response to treatment (good outcome).", "POS_RESPONSE_TO_HISTAMINE_DN": "Genes gradually down-regulated by histamine [PubChem=774] in B16-F10 melanoma tumors.", "POS_HISTAMINE_RESPONSE_NETWORK": "Genes corresponding to the histamine [PubChem=774] response network.", "POOLA_INVASIVE_BREAST_CANCER_DN": "Genes down-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH).", "POS_RESPONSE_TO_HISTAMINE_UP": "Genes gradually up-regulated by histamine [PubChem=774] in B16-F10 melanoma tumors.", "POOLA_INVASIVE_BREAST_CANCER_UP": "Genes up-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH).", "PRAMOONJAGO_SOX4_TARGETS_DN": "Genes down-regulated in ACC3 cells (adenoid cystic carcinoma) after knockdown of SOX4 [GeneID=6659] by RNAi.", "PRAMOONJAGO_SOX4_TARGETS_UP": "Genes up-regulated in ACC3 cells (adenoid cystic carcinoma) after knockdown of SOX4 [GeneID=6659] by RNAi.", "PROVENZANI_METASTASIS_DN": "Genes down-regulated in polysomal and total RNA samples from SW480 cells (primary colorectal carcinoma, CRC) compared to the SW620 cells (lymph node metastasis from the same individual).", "PUIFFE_INVASION_INHIBITED_BY_ASCITES_UP": "Genes up-regulated in OV-90 cells (ovarian cancer) exposed to ascites which inhibited invasion.", "PROVENZANI_METASTASIS_UP": "Genes up-regulated in polysomal and total RNA samples from SW480 cells (primary colorectal carcinoma, CRC) compared to the SW620 cells (lymph node metastasis from the same individual).", "PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN": "Genes down-regulated in OV-90 cells (ovarian cancer) exposed to ascites which inhibited invasion.", "PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_DN": "The XPRSS-Int network genes down-regulated in breast tumors from patients with germline mutations in BRCA1 [GeneID=672] compared to those with the wild type allele.", "PUJANA_BREAST_CANCER_LIT_INT_NETWORK": "Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature.", "PUJANA_BRCA_CENTERED_NETWORK": "Genes constituting the BRCA-centered network (BCN).", "PUJANA_BRCA1_PCC_NETWORK": "Genes constituting the BRCA1-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA1 [GeneID=672] across a compendium of normal tissues.", "PUJANA_ATM_PCC_NETWORK": "Genes constituting the ATM-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of ATM [GeneID=472] across a compendium of normal tissues.", "PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP": "The XPRSS-Int network genes up-regulated in breast tumors from patients with germline mutations in BRCA1 [GeneID=672] compared to those with the wild type allele.", "PUJANA_BRCA2_PCC_NETWORK": "Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues.", "PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN": "Genes down-regulated in HEK-293 cells (fibroblast) upon knockdown of both CTBP1 and SATB1 [GeneID=1487] [GeneID=6304] by RNAi.", "PUJANA_XPRSS_INT_NETWORK": "Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200] in a compendium of normal tissues.", "PUJANA_CHEK2_PCC_NETWORK": "Genes constituting the CHEK2-PCC network of transcripts whose expression positively correlates (Pearson correlation coefficient, PCC >= 0.4) with that of CHEK2 [GeneID=11200].", "PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP": "Genes up-regulated in HEK-293 cells (fibroblast) upon knockdown of both CTBP1 and SATB1 [GeneID=1487] [GeneID=6304] by RNAi.", "PURWIN_A375_MEWO_COMMON_SOX10_TARGETS": "Genes with a SOX10 ChIP-seq peak in the promoter region that are commonly down-regulated in two A375 and two MeWo CRISPR SOX10 knockout clones.", "PURWIN_MEWO_SOX10_TARGETS": "Genes with a SOX10 ChIP-seq peak in the promoter region that are commonly down-regulated (BHFDR < 0.05) in two MeWo CRISPR SOX10 knockout clones.", "PURWIN_A375_SOX10_TARGETS": "Genes with a SOX10 ChIP-seq peak in the promoter region that are commonly down-regulated (BHFDR < 0.05) in two A375 CRISPR SOX10 knockout clones.", "PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN": "Genes down-regulated in HEK-293 cells (fibroblast) upon knockdown of CTBP1 but not of SATB1 [GeneID=1487] [GeneID=6304] by RNAi.", "PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP": "Genes up-regulated in HEK-293 cells (fibroblast) upon knockdown of CTBP1 but not of SATB1 [GeneID=1487] [GeneID=6304] by RNAi.", "PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_DN": "Down-regulated genes in head and neck cancer compared to cervical carcinoma samples.", "PYEON_HPV_POSITIVE_TUMORS_DN": "Down-regulated genes in cervical carcinoma and head and neck tumors positive for human papilloma virus (HPV) compared to those negative for HPV.", "PYEON_HPV_POSITIVE_TUMORS_UP": "Up-regulated genes in cervical carcinoma and head and neck tumors positive for human papilloma virus (HPV) compared to those negative for HPV.", "PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP": "Up-regulated genes in head and neck cancer compared to cervical carcinoma samples.", "QI_HYPOXIA": "Genes up-regulated by hypoxia in TRAMP-C cells (prostatic cancer).", "QI_HYPOXIA_TARGETS_OF_HIF1A_AND_FOXA2": "Genes up-regulated by hypoxia in TRAMP-C cells (prostatic cancer) expressing HIF1A and FOXA2 [GeneID=3091] [GeneID=3170] off plasmid vectors.", "QI_PLASMACYTOMA_DN": "Down-regulated genes that best disciminate plasmablastic plasmacytoma from plasmacytic plasmacytoma tumors.", "RADAEVA_RESPONSE_TO_IFNA1_DN": "Genes down-regulated in primary hepatocytes and Hep3B (hepatocyte) cells in response to IFNA [GeneID=3439].", "QUINTENS_EMBRYONIC_BRAIN_RESPONSE_TO_IR": "Genes up-regulated in the mouse embryonic brain or immature neurons at 2 h or 6 h, respectively after exposure to 1 Gy dose of ionizing radiation.", "RADAEVA_RESPONSE_TO_IFNA1_UP": "Genes up-regulated in primary hepatocytes and Hep3B (hepatocyte) cells in response to IFNA [GeneID=3439].", "QI_PLASMACYTOMA_UP": "Up-regulated genes that best disciminate plasmablastic plasmacytoma from plasmacytic plasmacytoma tumors.", "RAFFEL_VEGFA_TARGETS_DN": "Genes down-regulated in hearts of E18.5 embryos upon knockout of VEGFA [GeneID=7422].", "RAFFEL_VEGFA_TARGETS_UP": "Genes up-regulated in hearts of E18.5 embryos upon knockout of VEGFA [GeneID=7422].", "RADMACHER_AML_PROGNOSIS": "The 'Bullinger validation signature' [PMID=15084693] used to validate prediction of prognostic outcome of acute myeloid leukemia (AML) patients with a normal karyotype.", "RAHMAN_TP53_TARGETS_PHOSPHORYLATED": "Proteins phosporylated in HCT116 cells (colon cancer) upon p53 [GeneID=7157] activation.", "RAGHAVACHARI_PLATELET_SPECIFIC_GENES": "Genes in this set correspond to the most abuntant transcripts that are also specific to platelets.", "RAMALHO_STEMNESS_DN": "Genes depleted in embryonic, neural and hematopoietic stem cells.", "RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_MAPK1_DN": "Apoptotic genes dependent on MAPK1 [GeneID=5594] and down-regulated in AML12 cells (hepatocytes) after stimulation with TGFB1 [GeneID=7040].", "RAMALHO_STEMNESS_UP": "Genes enriched in embryonic, neural and hematopoietic stem cells.", "RAMASWAMY_METASTASIS_DN": "Down-regulated genes in metastatic vs primary solid tumors.", "RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_MAPK1_UP": "Apoptotic genes dependent on MAPK1 [GeneID=5594] and up-regulated in AML12 cells (hepatocytes) after stimulation with TGFB1 [GeneID=7040].", "RAMASWAMY_METASTASIS_UP": "Up-regulated genes in metastatic vs primary solid tumors.", "RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_SMAD4_DN": "Apoptotic genes dependent on SMAD4 [GeneID=4089] and down-regulated in AML12 cells (hepatocytes) after stimulation with TGFB1 [GeneID=7040].", "RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_SMAD4_UP": "Apoptotic genes dependent on SMAD4 [GeneID=4089] and up-regulated in AML12 cells (hepatocytes) after stimulation with TGFB1 [GeneID=7040].", "RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_DN": "Genes down-regulated in the brain cortex of mice that were exposed to an enriched learning environment for one day.", "RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_UP": "Genes up-regulated in the brain cortex of mice that were exposed to an enriched learning environment for one day.", "RANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_DN": "Angiogenic genes down-regulated in hepatocytes after knockout of VHL and HIF2A [GeneID=7428;2034].", "RANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_UP": "Angiogenic genes up-regulated in hepatocytes after knockout of VHL and HIF2A [GeneID=7428;2034].", "RAMPON_ENRICHED_LEARNING_ENVIRONMENT_LATE_UP": "Genes up-regulated in the brain cortex of mice that were exposed to an enriched learning environment for 2 or 14 days.", "RASHI_RESPONSE_TO_IONIZING_RADIATION_1": "Cluster 1: ATM [GeneID=472] dependent genes induced at 30 min after ionizing radiation treatment.", "RASHI_NFKB1_TARGETS": "Known and putative targets of NFKB1 [GeneID=4790] identified among the ATM [GeneID=472] dependent, late responders to ionizing radiation.", "RAO_BOUND_BY_SALL4": "Loci bound by both isoforms (a and b) of SALL4 [GeneID=57167] in ES cells (embryonic stem).", "RASHI_RESPONSE_TO_IONIZING_RADIATION_3": "Cluster 3: genes activated by ionizing radiation regardless of ATM [GeneID=472] status.", "RAO_BOUND_BY_SALL4_ISOFORM_A": "Loci bound exclusively by SALL4 [GeneID=57167] isoform a in ES cells (embryonic stem).", "RASHI_RESPONSE_TO_IONIZING_RADIATION_4": "Cluster 4: genes repressed by ionizing radiation regardless of ATM [GeneID=472] status.", "RASHI_RESPONSE_TO_IONIZING_RADIATION_2": "Cluster 2: late ATM [GeneID=472] dependent genes induced by ionizing radiation treatment.", "RAO_BOUND_BY_SALL4_ISOFORM_B": "Loci bound exclusively by SALL4 [GeneID=57167] isoform b in ES cells (embryonic stem).", "RASHI_RESPONSE_TO_IONIZING_RADIATION_5": "Cluster 5: early responding genes activated in ATM [GeneID=472] deficient but not in the wild type tissues.", "RASHI_RESPONSE_TO_IONIZING_RADIATION_6": "Cluster 6: late responding genes activated in ATM [GeneID=472] deficient but not in the wild type tissues.", "RAY_ALZHEIMERS_DISEASE": "A biomarker of plasma signaling proteins that predicts clinical Alzheimer's diagnosis.", "RAY_TARGETS_OF_P210_BCR_ABL_FUSION_DN": "Genes down-regulated in HL-60 cells (acute myeloid leukemia, AML) by expression of p210 BCR-ABL [GeneID=613;25] fusion protein.", "REICHERT_MITOSIS_LIN9_TARGETS": "Genes with known mitosis function that were down-regulated in MEF cells (embryonic fibroblast) upon knockout of LIN9 [GeneID=286826].", "REICHERT_G1S_REGULATORS_AS_PI3K_TARGETS": "G1 to S phase regulators significantly changed in DanG cells (pancreatic cancer) treated with Ly294002 [PubChem=3973], a phosphoinositide 3-kinase (PI3K) inhibitor.", "RAY_TARGETS_OF_P210_BCR_ABL_FUSION_UP": "Genes up-regulated in HL-60 cells (acute myeloid leukemia, AML) by expression of p210 BCR-ABL [GeneID=613;25] fusion protein.", "RATTENBACHER_BOUND_BY_CELF1": "Transcripts bound by CELF1 [GeneID=10658] in HeLa cells (cervical carcinoma).", "RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP": "Up-regulated genes in breast tumors from transgenic mice overexpressing ERBB2 and CDC25A [GeneID=2064;993] compared to those from mice overexpressing ERBB2 only.", "RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN": "Down-regulated genes in breast tumors from transgenic mice overexpressing ERBB2 and CDC25A [GeneID=2064;993] compared to those from mice overexpressing ERBB2 only.", "REN_ALVEOLAR_RHABDOMYOSARCOMA_UP": "Genes commonly up-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion.", "REN_BOUND_BY_E2F": "Genes whose promoters were bound by E2F1 and E2F4 [GeneID=1869;1874] in the primary fibroblasts WI-38, by ChIP on chip assay.", "REN_ALVEOLAR_RHABDOMYOSARCOMA_DN": "Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion.", "REN_MIF_TARGETS_DN": "Genes down-regulated in SK-N-DZ cells (neuroblastoma) after knockdown of MIF [GeneID=4282] by antisense RNA.", "RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP": "Genes up-regulated in ALL (acute lymphoblastic leukemia) blasts after 1 week of treatment with glucocorticoids.", "RHODES_CANCER_META_SIGNATURE": "Genes commonly up-regulated in cancer relative to normal tissue, according to the meta-analysis of the OncoMine gene expression database.", "RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN": "Genes down-regulated in ALL (acute lymphoblastic leukemia) blasts after 1 week of treatment with glucocorticoids.", "RHODES_UNDIFFERENTIATED_CANCER": "Genes commonly up-regulated in undifferentiated cancer relative to well-differentiated cancer, based on the meta-analysis of the OncoMine gene expression database.", "RICKMAN_HEAD_AND_NECK_CANCER_A": "Cluster a: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC).", "RICKMAN_HEAD_AND_NECK_CANCER_B": "Cluster b: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC).", "RICKMAN_HEAD_AND_NECK_CANCER_C": "Cluster c: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC).", "RICKMAN_HEAD_AND_NECK_CANCER_D": "Cluster d: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC).", "RICKMAN_HEAD_AND_NECK_CANCER_F": "Cluster f: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC).", "RICKMAN_HEAD_AND_NECK_CANCER_E": "Cluster e: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC).", "RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_DN": "Down-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: moderately vs poorly differentiated tumors.", "RICKMAN_METASTASIS_DN": "Genes down-regulated in metastatic vs non-metastatic HNSCC (head and neck squamous cell carcinoma) samples.", "RICKMAN_METASTASIS_UP": "Genes up-regulated in metastatic vs non-metastatic HNSCC (head and neck squamous cell carcinoma) samples.", "RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP": "Up-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: moderately vs poorly differentiated tumors.", "RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_DN": "Down-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: well vs moderately differentiated tumors.", "RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_UP": "Up-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: well vs moderately differentiated tumors.", "RIEGE_DELTANP63_DIRECT_TARGETS_UP": "Genes directly up-regulated by DeltaNp63, the p63 isoform that lacks the canonical transactivation domain and is predominantly expressed in stratifying epithelia, identified through a meta-analysis of both cell lines and primary cells.", "RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN": "Down-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: well vs poorly differentiated tumors.", "RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP": "Up-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: well vs poorly differentiated tumors.", "RIGGINS_TAMOXIFEN_RESISTANCE_DN": "Genes down-regulated SUM44/LCCTam cells (breast cancer) resistant to 4-hydroxytamoxifen [PubChem=63062] relative to the parental SUM44 cells sensitive to the drug.", "RIGGINS_TAMOXIFEN_RESISTANCE_UP": "Genes up-regulated SUM44/LCCTam cells (breast cancer) resistant to 4-hydroxytamoxifen [PubChem=63062] relative to the parental SUM44 cells sensitive to the drug.", "RIZKI_TUMOR_INVASIVENESS_2D_DN": "Genes down-regulated in monolayer (2D) cultures of preinvasive (S3-C) vs invasive (T4-2) breast cancer cells.", "RIZKI_TUMOR_INVASIVENESS_2D_UP": "Genes up-regulated in monolayer (2D) cultures of preinvasive (S3-C) vs invasive (T4-2) breast cancer cells.", "RIGGI_EWING_SARCOMA_PROGENITOR_DN": "Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein.", "RIGGI_EWING_SARCOMA_PROGENITOR_UP": "Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein.", "RIZ_ERYTHROID_DIFFERENTIATION": "Selected gradually up-regulated genes in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts).", "RIZ_ERYTHROID_DIFFERENTIATION_APOBEC2": "Selected genes whose expression profile follows that of APOBEC2 [GeneID=10930] in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts).", "RIZ_ERYTHROID_DIFFERENTIATION_12HR": "Selected genes down-regulated in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts) at 12 h time point.", "RIZKI_TUMOR_INVASIVENESS_3D_UP": "Genes up-regulated in three-dimentional (3D) cultures of preinvasive (S3-C) vs invasive (T4-2) breast cancer cells.", "RIZ_ERYTHROID_DIFFERENTIATION_6HR": "Selected genes down-regulated in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts) at 6 h time point.", "RIZKI_TUMOR_INVASIVENESS_3D_DN": "Genes down-regulated in three-dimentional (3D) cultures of preinvasive (S3-C) vs invasive (T4-2) breast cancer cells.", "RIZ_ERYTHROID_DIFFERENTIATION_CCNE1": "Selected gradually up-regulated genes whose expression profile follows that of CCNE1 [GeneID=898] in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts).", "RIZ_ERYTHROID_DIFFERENTIATION_HBZ": "Selected gradually up-regulated genes whose expression profile follows that of HBZ [GeneID=3050] in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts).", "RIZ_ERYTHROID_DIFFERENTIATION_HEMGN": "Selected gradually up-regulated genes whose expression profile follows that of HEMGN [GeneID=55363] in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts).", "RODRIGUES_DCC_TARGETS_UP": "Genes up-regulated in HCT8/S1 cells (colon cancer) which normally lack DCC [GeneID=9423] compared to those stably expressing wild type DCC off a plasmid vector.", "RODRIGUES_DCC_TARGETS_DN": "Genes down-regulated in HCT8/S1 cells (colon cancer) which normally lack DCC [GeneID=9423] compared to those stably expressing wild type DCC off a plasmid vector.", "RODRIGUES_NTN1_TARGETS_UP": "Genes up-regulated in HCT8/S11 cells (colon cancer) engineered to stably express NTN1 [GeneID=1630] off a plasmid vector.", "RODRIGUES_NTN1_AND_DCC_TARGETS": "Genes down-regulated in HCT8/S11 cells (colon cancer) which lack DCC [GeneID=9423] and stably express NTN1 [GeneID=1630].", "RODRIGUES_NTN1_TARGETS_DN": "Genes down-regulated in HCT8/S11 cells (colon cancer) engineered to stably express NTN1 [GeneID=1630] off a plasmid vector.", "RODRIGUES_THYROID_CARCINOMA_DN": "Genes down-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to anaplastic thyroid carcinoma (ATC).", "RODRIGUES_THYROID_CARCINOMA_UP": "Genes up-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to anaplastic thyroid carcinoma (ATC).", "RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN": "Genes down-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue.", "RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP": "Genes up-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue.", "RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN": "Genes down-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to normal thyroid tissue.", "RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP": "Genes up-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to normal thyroid tissue.", "RODWELL_AGING_KIDNEY_NO_BLOOD_DN": "Genes whose expression decreases with age in normal kidney, excluding those with higher expression in blood.", "RODWELL_AGING_KIDNEY_DN": "Genes whose expression decreases with age in normal kidney.", "RODWELL_AGING_KIDNEY_NO_BLOOD_UP": "Genes whose expression increases with age in normal kidney, excluding those with higher expression in blood.", "ROESSLER_LIVER_CANCER_METASTASIS_DN": "Genes down-regulated in liver samples containing tumor thrombi in the major branches of the portal vein at surgery (PT) compared to those from metastasis-free HCC patients (PN) at the time of surgery and at follow-up.", "ROETH_TERT_TARGETS_DN": "Genes down-regulated in T lymphocytes overexpressing TERT [GeneID=7015] off a retrovirus vector.", "ROESSLER_LIVER_CANCER_METASTASIS_UP": "Genes up-regulated in liver samples containing tumor thrombi in the major branches of the portal vein at surgery (PT) compared to those from metastasis-free HCC patients (PN) at the time of surgery and at follow-up.", "RODWELL_AGING_KIDNEY_UP": "Genes whose expression increases with age in normal kidney.", "ROETH_TERT_TARGETS_UP": "Genes up-regulated in T lymphocytes overexpressing TERT [GeneID=7015] off a retrovirus vector.", "RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_DN": "Neuroblastoma markers down-regulated in neuroblastoma cell lines expressing ESWR1-FLI1 [GeneID=2130;2313] fusion protein.", "ROPERO_HDAC2_TARGETS": "Genes up-regulated genes in cell lines with HDAC2 [GeneID=3066] loss of function (LOS).", "RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_UP": "ES/PNET (Ewing sarcoma; primitive neuroectodermal tumors) markers up-regulated in neuroblastoma cell lines expressing ESWR1-FLI1 [GeneID=2130;2313] fusion protein.", "ROSS_ACUTE_MYELOID_LEUKEMIA_CBF": "Top 100 probe sets for core-binding factor (CBF) acute myeloid leukemia (AML): contains CBFB MYH11 [GeneID=865;4629] or AML1 ETO [GeneID=861;862] fusions.", "ROSS_AML_WITH_AML1_ETO_FUSION": "Top 100 probe sets for pediatric acute myeloid leukemia (AML) subtype t(8;21) ; has AML1 ETO fusion [GeneID=861;862].", "ROSS_AML_OF_FAB_M7_TYPE": "Top 100 probe sets for pediatric acute myeloid leukemia (AML) subtype FAB M7 (also known as acute megakaryoblastic leukemia, AMKL).", "ROSS_AML_WITH_CBFB_MYH11_FUSION": "Top 63 probe sets for pediatric acute myeloid leukemia (AML) subtype inv(16); has a CBFB-MYH11 fusion [GeneID=865;4629].", "ROSS_AML_WITH_PML_RARA_FUSION": "Top 100 probe sets for pediatric acute myeloid leukemia (AML) subtype t(15;17): has PML RARA fusion [GeneID=5371;5914].", "ROSS_AML_WITH_MLL_FUSIONS": "Top 100 probe sets for pediatric acute myeloid leukemia (AML) subtypes with chimeric MLL fusions [GeneID=4297].", "ROSS_LEUKEMIA_WITH_MLL_FUSIONS": "Top 100 probe sets associated with MLL fusions [GeneID=4297] irrespective of the lineage of the pediatric acute leukemia.", "ROVERSI_GLIOMA_COPY_NUMBER_DN": "Genes in the most frequently homozygous deleted loci in a panel of glioma cell lines.", "ROVERSI_GLIOMA_COPY_NUMBER_UP": "Genes in the most frequently gained loci in a panel of glioma cell lines.", "ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_DN": "Genes in discrete regions of loss within 16q region detected in individual invasive breast cancer tumors.", "ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER": "The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome.", "ROVERSI_GLIOMA_LOH_REGIONS": "Genes in the most frequently heterozygous deleted loci of a panel of glioma cell lines.", "ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP": "Genes in discrete regions of gain within 16q region detected in individual invasive breast cancer tumors.", "ROY_WOUND_BLOOD_VESSEL_DN": "Genes down-regulated in blood vessel cells from wound site.", "ROY_WOUND_BLOOD_VESSEL_UP": "Genes up-regulated in blood vessel cells from wound site.", "ROZANOV_MMP14_CORRELATED": "Genes whose expression most uniformly correlated with that of MMP14 [GeneID=4323] both in HT1080 cells (fibrosarcoma) and in 190 human tumors.", "ROZANOV_MMP14_TARGETS_DN": "Genes down-regulated in HT1080 cells (fibrosarcoma) over-expressing MMP14 [GeneID=4323] compared to those with knockdown of the gene by RNAi.", "ROZANOV_MMP14_TARGETS_SUBSET": "Genes linked to the ECM maintenance and angiogenesis that were changed in HT1080 cells (fibrosarcoma) over-expressing MMP14 [GeneID=4323] compared to those with knockdown of the gene by RNAi.", "RUAN_RESPONSE_TO_TNF_TROGLITAZONE_UP": "Adipocyte abundant genes up-regulated in 3T3-L1 cells (fibroblasts induced to differentiate to adipocytes) in response to troglitazone [PubChem=5591] and TNF [GeneID=7124].", "RUAN_RESPONSE_TO_TNF_TROGLITAZONE_DN": "Adipocyte abundant genes down-regulated in 3T3-L1 cells (fibroblasts induced to differentiate to adipocytes) in response to troglitazone [PubChem=5591] and TNF [GeneID=7124].", "ROZANOV_MMP14_TARGETS_UP": "Genes up-regulated in HT1080 cells (fibrosarcoma) over-expressing MMP14 [GeneID=4323] compared to those with knockdown of the gene by RNAi.", "RUAN_RESPONSE_TO_TNF_UP": "Adipocyte abundant genes up-regulated in 3T3-L1 cells (fibroblasts induced to differentiate to adipocytes) in response to TNF [GeneID=7124].", "RUAN_RESPONSE_TO_TROGLITAZONE_DN": "Adipocyte abundant genes down-regulated in 3T3-L1 cells (fibroblasts induced to differentiate to adipocytes) in response to troglitazone [PubChem=5591].", "RUAN_RESPONSE_TO_TNF_DN": "Adipocyte abundant genes down-regulated in 3T3-L1 cells (fibroblasts induced to differentiate to adipocytes) in response to TNF [GeneID=7124].", "RUAN_RESPONSE_TO_TROGLITAZONE_UP": "Adipocyte abundant genes up-regulated in 3T3-L1 cells (fibroblasts induced to differentiate to adipocytes) in response to troglitazone [PubChem=5591].", "RUIZ_TNC_TARGETS_UP": "Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371].", "RUIZ_TNC_TARGETS_DN": "Genes down-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371].", "RUNNE_GENDER_EFFECT_UP": "Up-regulated genes detecting gender effects in global expression profiling studies.", "RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN": "Genes down-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565].", "RUTELLA_RESPONSE_TO_HGF_DN": "Genes down-regulated in peripheral blood monocytes by HGF [GeneID=3082].", "RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN": "Genes down-regulated in peripheral blood mononucleocytes by HGF [GeneID=3082] compared to those regulated by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565].", "RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP": "Genes up-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565].", "RUTELLA_RESPONSE_TO_HGF_UP": "Genes up-regulated in peripheral blood monocytes by HGF [GeneID=3082].", "SABATES_COLORECTAL_ADENOMA_SIZE_DN": "A selection of genes whose expression displayed significant negative correlation with size of colorectal adenoma.", "RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP": "Genes upregulated by rapid Notch activation and linked to Notch TF binding peaks in mantle cell lymphoma cell lines.", "RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP": "Genes up-regulated in peripheral blood mononucleocytes by HGF [GeneID=3082] compared to those regulated by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565].", "SABATES_COLORECTAL_ADENOMA_SIZE_UP": "A selection of genes whose expression displayed significant positive correlation with size of colorectal adenoma.", "SABATES_COLORECTAL_ADENOMA_DN": "Genes down-regulated in colorectal adenoma compared to normal mucosa samples.", "SAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN": "Detoxification pathway genes down-regulated in enterocytes of transgenic mice expressing SV40 T antigen.", "SAFFORD_T_LYMPHOCYTE_ANERGY": "Genes up-regulated in anergic mouse T helper cells (A.E7), versus non-anergic stimulated controls", "SAGIV_CD24_TARGETS_DN": "Genes down-regulated in HT29 cells (colon cancer) after knockdown of CD24 [GeneID=100133941] by both RNAi and monoclonal antibodies.", "SABATES_COLORECTAL_ADENOMA_UP": "Genes up-regulated in colorectal adenoma compared to normal mucosa samples.", "SAGIV_CD24_TARGETS_UP": "Genes up-regulated in HT29 cells (colon cancer) after knockdown of CD24 [GeneID=100133941] by both RNAi and monoclonal antibodies.", "SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_DN": "Selected genes down-regulated in peripheral blood monocytes (PBMC) of patients with hepatocellular carcinoma (HCC) compared to those with chronic hepatitis.", "SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP": "Selected genes up-regulated in peripheral blood monocytes (PBMC) of patients with hepatocellular carcinoma (HCC) compared to those with chronic hepatitis.", "SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN": "Selected genes down-regulated in inflammatory monocytes infiltrating hepatocellular carcinoma (HCC).", "SALVADOR_MARTIN_PEDIATRIC_TBD_ANTI_TNF_THERAPY_NONRESPONDER_POST_TREATMENT_DN": "Genes downregulated in anti-TNF therapy non-responders vs. responders after two weeks of anti-TNF therapy", "SAKAI_TUMOR_INFILTRATING_MONOCYTES_UP": "Selected genes up-regulated in inflammatory monocytes infiltrating hepatocellular carcinoma (HCC).", "SALVADOR_MARTIN_PEDIATRIC_TBD_ANTI_TNF_THERAPY_NONRESPONDER_POST_TREATMENT_UP": "Genes upregulated in anti-TNF therapy non-responders vs. responders after two weeks of anti-TNF therapy", "SALVADOR_MARTIN_PEDIATRIC_TBD_ANTI_TNF_THERAPY_NONRESPONDER_PRE_TREATMENT_UP": "Genes upregulated in anti-TNF therapy non-responders vs. responders prior to the initiation of anti-TNF therapy", "SAMOLS_TARGETS_OF_KHSV_MIRNAS_UP": "Genes up-regulated in 293 cells (embryonic kidney) upon expression of KHSV (Kaposi sarcoma-associated herpesvirus) microRNAs.", "SANA_RESPONSE_TO_IFNG_DN": "Genes down-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by IFNG [GeneID=3458].", "SAMOLS_TARGETS_OF_KHSV_MIRNAS_DN": "Genes down-regulated in 293 cells (embryonic kidney) upon expression of KHSV (Kaposi sarcoma-associated herpesvirus) microRNAs.", "SANA_TNF_SIGNALING_DN": "Genes down-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124].", "SANA_TNF_SIGNALING_UP": "Genes up-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124].", "SANA_RESPONSE_TO_IFNG_UP": "Genes up-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by IFNG [GeneID=3458].", "SANCHEZ_MDM2_TARGETS": "Genes up-regulated in BJ cells (forskin fibroblasts) upon overexpression of the most abundant alternative splicing forms of MDM2 [GeneID=4193], HDM2-A and HDM2-B, off a retroviral vector.", "SANDERSON_PPARA_TARGETS": "Hepatic genes regulated by fasting or in response to WY14643 [PubChem=5694] and which require intact PPARA [GeneID=5465].", "SANSOM_APC_MYC_TARGETS": "Genes down-regulated after double Cre-lox knockout  of both APC and MYC [GeneID=324;4609] in small intestine.", "SANSOM_WNT_PATHWAY_REQUIRE_MYC": "Wnt target genes up-regulated after Cre-lox knockout of APC [GeneID=324] in the small intestine that require functional MYC [GeneID=4609].", "SARTIPY_BLUNTED_BY_INSULIN_RESISTANCE_DN": "Genes down-regulated in 3T3-L1 cells (adipocyte) by insulin [GeneID=3630] but displayed blunted response to insulin the insulin resistant cells.", "SANSOM_APC_TARGETS_UP": "Top genes up-regulated at day 5 of Cre-Lox induced APC [GeneID=324] knockout in the intestine.", "SARTIPY_BLUNTED_BY_INSULIN_RESISTANCE_UP": "Genes up-regulated in 3T3-L1 cells (adipocyte) by insulin [GeneID=3630] but displayed blunted response to insulin the insulin resistant cells.", "SANSOM_APC_TARGETS_DN": "Top genes down-regulated at day 5 of Cre-Lox induced APC [GeneID=324] knockout in the intestine.", "SANSOM_APC_TARGETS": "Genes up-regulated after Cre-lox knockout of APC [GeneID=324] in the small intestine.", "SANSOM_APC_TARGETS_REQUIRE_MYC": "Genes up-regulated after Cre-lox knockout of APC [GeneID=324] in the small intestine that require functional MYC [GeneID=4609].", "SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN": "Genes down-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency.", "SARTIPY_NORMAL_AT_INSULIN_RESISTANCE_DN": "Genes down-regulated in 3T3-L1 cells (adipocyte) by insulin [GeneID=3630] which continued to respond normally to insulin in the insulin resistant cells.", "SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP": "Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency.", "SARTIPY_NORMAL_AT_INSULIN_RESISTANCE_UP": "Genes up-regulated in 3T3-L1 cells (adipocyte) by insulin [GeneID=3630] which continued to respond normally to insulin in the insulin resistant cells.", "SASAI_TARGETS_OF_CXCR6_AND_PTCH1_DN": "Down-regulated genes in medulloblastoma tumors from heterozygotic CXCR6 [GeneID=10663] knockout mice compared to those from PTCH1 [GeneID=5727] heterozygotic knockout mice.", "SASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION": "Genes down-regulated in MEF and REF cells (mouse and rat fibroblasts) but not in TIG3/T cells (human lung fibroblasts expressing TERT [GeneID=7015]) by co-expression of the SV40 early region and the activated HRAS (H-RasV12) [GeneID=3265].", "SASAI_TARGETS_OF_CXCR6_AND_PTCH1_UP": "Up-regulated genes in medulloblastoma tumors from heterozygotic CXCR6 [GeneID=10663] knockout mice compared to those from PTCH1 [GeneID=5727] heterozygotic knockout mice.", "SASAKI_TARGETS_OF_TP73_AND_TP63": "Genes up-regulated in DLD1 cells (colon cancer) by p73 beta [GeneID=7161] or by and p63 gamma [GeneID=8626] but not by p53 [GeneID=7157].", "SASSON_FSH_RESPONSE": "Genes up-regulated in rFSH-17 cells (primary granulosa) after stimulation with FSH.", "SASAKI_ADULT_T_CELL_LEUKEMIA": "Genes up-regulated in adult T-cell leukemia (ATL) cells compared to T lymphocytes from healthy controls.", "SASSON_RESPONSE_TO_GONADOTROPHINS_DN": "Genes down-regulated in primary granulosa cells after stimulation with LH or FSH gonadotrophic hormones for 24 h.", "SASSON_RESPONSE_TO_FORSKOLIN_UP": "Genes up-regulated in primary granulosa cells in response to forskolin [PubChem=47936].", "SASSON_RESPONSE_TO_FORSKOLIN_DN": "Genes down-regulated in primary granulosa cells in response to forskolin [PubChem=47936].", "SATO_SILENCED_BY_DEACETYLATION_IN_PANCREATIC_CANCER": "50 most interesting genes up-regulated in pancreatic cancer cell lines (AsPC1, Hs766T, MiaPaCa2, Panc1) but not in the non-neoplastic cells (HPDE) by TSA [PubChem=5562].", "SASSON_RESPONSE_TO_GONADOTROPHINS_UP": "Genes up-regulated in primary granulosa cells after stimulation with LH or FSH gonadotrophic hormones for 24 h.", "SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2": "50 most interesting genes up-regulated in the pancreatic cancer cell lines (AsPC1, Hs766T, MiaPaCa2, Panc1) but not in the non-neoplastic cells (HPDE) by decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].", "SATO_SILENCED_EPIGENETICALLY_IN_PANCREATIC_CANCER": "50 genes up-regulated in the pancreatic cancer cell lines (AsPC1, Hs766T, MiaPaCa2, Panc1) but not in the non-neoplastic cells (HPDE) by the combination of decitabine  and TSA [PubChem=451668;5562].", "SAUL_SEN_MAYO": "Genes upregulated in senescent cells: Senescence-associated secretory phenotype (SASP).", "SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP": "Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 12 h.", "SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1": "Genes up-regulated in the pancreatic cancer cell lines (AsPC1, Hs766T, MiaPaCa2, Panc1) but not in the non-neoplastic cells (HPDE) by decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].", "SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN": "Genes down-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 12 h.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX1_DN": "Early prostate development genes (down-regulated at 6 h dihydrotestosterone [PubChem=10635]) which are also down-regulated in normal epithelium vs high grade prostatic intraepithelial neoplasia (PIN).", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX1_UP": "Early prostate development genes (up-regulated at 6 h dihydrotestosterone [PubChem=10635]) which are also up-regulated in normal epithelium vs high grade prostatic intraepithelial neoplasia (PIN).", "SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP": "Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h.", "SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP": "Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 6 h.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX2_DN": "Early prostate development genes (down-regulated at 6 hr dihydrotestosterone [PubChem=10635]) which are also down-regulated in high grade prostatic intraepithelial neoplasia (PIN) vs invasive cancer.", "SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN": "Genes down-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 6 h.", "SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN": "Genes down-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX2_UP": "Early prostate development genes (up-regulated at 6 hr dihydrotestosterone [PubChem=10635]) which are also up-regulated in high grade prostatic intraepithelial neoplasia (PIN) vs invasive cancer.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX3": "Early prostate development genes (up-regulated at 6 hr dihydrotestosterone [PubChem=10635]) which are also up-regulated in lower grade vs higher grade locally invasive prostate cancers.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_UP": "Early prostate development genes (up-regulated at 6 hr dihydrotestosterone [PubChem=10635]) which are also up-regulated in localized vs metastatic prostate cancers.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX5_DN": "Early prostate development genes (down-regulated at 12 hr dihydrotestosterone [PubChem=10635]) which are also down-regulated in high grade prostatic intraepithelial neoplasia (PIN) vs invasive cancer.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_DN": "Early prostate development genes (down-regulated at 6 hr dihydrotestosterone [PubChem=10635]) which are also down-regulated in localized vs metastatic prostate cancers.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX6_DN": "Early prostate development genes (down-regulated at 48 hr dihydrotestosterone [PubChem=10635]) which are also down-regulated in high grade prostatic intraepithelial neoplasia (PIN) vs invasive cancer.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX5_UP": "Early prostate development genes (up-regulated at 12 hr dihydrotestosterone [PubChem=10635]) which are also up-regulated in high grade prostatic intraepithelial neoplasia (PIN) vs invasive cancer.", "SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX6_UP": "Early prostate development genes (up-regulated at 48 hr dihydrotestosterone [PubChem=10635]) which are also up-regulated in high grade prostatic intraepithelial neoplasia (PIN) vs invasive cancer.", "SCHAVOLT_TARGETS_OF_TP53_AND_TP63": "Genes up-regulated by TP53 [GeneID=7157]  and down-regulated by an isoform of TP63 [GeneID=8626] in primary HEK cells (epidermal keratinocytes).", "SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_DN": "Predicted targets of SOX9 [GeneID=6662] that are down-regulated during early prostate development.", "SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_UP": "Predicted targets of SOX9 [GeneID=6662] that are up-regulated during early prostate development.", "SCHEIDEREIT_IKK_INTERACTING_PROTEINS": "Genes encoding IkappaB kinase (IKK) interacting proteins.", "SCHEIDEREIT_IKK_TARGETS": "Genes encoding substrates of IkappaB kinase (IKK) complex.", "SCHLESINGER_H3K27ME3_IN_NORMAL_AND_METHYLATED_IN_CANCER": "Genes bearing the H3K27me3 mark in normal cells; their DNA is methylated in cancer cells.", "SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER": "Genes bearing H3K27me3 mark or whose promoters are bound by the polycomb proteins SUZ12 or EED [GeneID=23512;8726]; their DNA is methylated de novo in cancer.", "SCHLESINGER_METHYLATED_IN_COLON_CANCER": "Genes expressed in normal colon; they undergo down-regulation in tumors through DNA methylation.", "SCHLINGEMANN_SKIN_CARCINOGENESIS_TPA_DN": "Down-regulated in murine dorsal skin cells at 6 h after treatment with the phorbol ester carcinogen TPA [PubChem=4792].", "SCHLINGEMANN_SKIN_CARCINOGENESIS_TPA_UP": "Up-regulated in murine dorsal skin cells at 6 h after treatment with the phorbol ester carcinogen TPA [PubChem=4792].", "SCHLOSSER_MYC_AND_SERUM_RESPONSE_SYNERGY": "Cluster 3: genes strongly up-regulated in B493-6 cells (B lymphocytes) by a combination of MYC [GeneID=4609] and serum but not by each of them alone.", "SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN": "Cluster 6: genes down-regulated in B493-6 cells (B lymphocytes) by MYC [GeneID=4609] in combination with serum but not affected by serum alone; they are also up-regulated by MYC alone.", "SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_UP": "Cluster 5: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [GeneID=4609] alone or in combination with serum but not by serum alone.", "SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC": "Cluster 2: genes up-regulated in B493-6 cells (B lymphocytes) by serum alone or in combination with MYC [GeneID=4609] but not by MYC alone.", "SCHMAHL_PDGF_SIGNALING": "These genes form a a network that controls specific processes downstream of PDGF signaling.", "SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM": "Cluster 7: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [GeneID=4609] and down-regulated by the combination of MYC and serum.", "SCHMIDT_POR_TARGETS_IN_LIMB_BUD_DN": "Genes down-regulated in E12.5 forelimb buds with POR [GeneID=5447] knockout.", "SCHLOSSER_SERUM_RESPONSE_UP": "Cluster 1: genes up-regulated in B493-6 cells (B lymphocytes) upon serum stimulation but not by affected by MYC [GeneID=4609].", "SCHMIDT_POR_TARGETS_IN_LIMB_BUD_UP": "Genes up-regulated in E12.5 forelimb buds with POR [GeneID=5447] knockout.", "SCHOEN_NFKB_SIGNALING": "Genes down-regulated in A375 cells (melanoma) treated with KINK-1, a small molecule inhibitor of NFKB.", "SCHRAETS_MLL_TARGETS_DN": "Genes down-regulated in fibroblasts from MLL [GeneID=4297] knockout mice.", "SCHLOSSER_SERUM_RESPONSE_DN": "Cluster 4: genes down-regulated in B493-6 cells (B lymphocytes) upon serum stimulation but not affected by MYC [GeneID=4609].", "SCHRAETS_MLL_TARGETS_UP": "Genes up-regulated in fibroblasts from MLL [GeneID=4297] knockout mice.", "SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_DN": "Genes down-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive).", "SCHUHMACHER_MYC_TARGETS_DN": "Genes down-regulated in P493-6 cells (Burkitt's lymphoma) induced to express MYC [GeneID=4609].", "SCHWAB_TARGETS_OF_BMYB_POLYMORPHIC_VARIANTS_UP": "Genes up-regulated in 293 cells (embryonic kidney) expressing  polymorphic variants S427G (SNP ID=rs2070235) or I624M (SNP ID=rs11556379) of BMYB [GeneID=4605].", "SCHUHMACHER_MYC_TARGETS_UP": "Genes up-regulated in P493-6 cells (Burkitt's lymphoma) induced to express MYC [GeneID=4609].", "SCHWAB_TARGETS_OF_BMYB_POLYMORPHIC_VARIANTS_DN": "Genes down-regulated in 293 cells (embryonic kidney) expressing  polymorphic variants S427G (SNP ID=rs2070235) or I624M (SNP ID=rs11556379) of BMYB [GeneID=4605].", "SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP": "Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive).", "SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_DN": "Cell cycle genes down-regulated in H1299 cells (lung cancer) after overexpression of either P53 or P73 [GeneID=7157;7161].", "SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_UP": "Cell cycle genes up-regulated in H1299 cells (lung cancer) after overexpression of either P53 or P73 [GeneID=7157;7161].", "SCIAN_INVERSED_TARGETS_OF_TP53_AND_TP73_UP": "Genes that were inversely correlated in H1299 cells (lung cancer): up-regulated by P53 [GeneID=7157] and down-regulated by P73 [GeneID=7161].", "SCIAN_INVERSED_TARGETS_OF_TP53_AND_TP73_DN": "Genes that were inversely correlated in H1299 cells (lung cancer): down-regulated by P53 [GeneID=7157] and up-regulated by P73 [GeneID=7161].", "SCIBETTA_KDM5B_TARGETS_UP": "Genes up-regulated in HB2 cells (mammary epithelium) upon expression of KDM5B [GeneID=10765] off an adenoviral vector.", "SEIDEN_MET_SIGNALING": "Genes down-regulated both in vivo and in vitro upon activation of MET [GeneID=4233] signaling.", "SEAVEY_EPITHELIOID_HEMANGIOENDOTHELIOMA": "Genes overexpressed in Epithelioid Hemangioendothelioma versus Angiosarcoma, Kaposi Sarcoma, Hemangioblastoma, and Liver", "SCIBETTA_KDM5B_TARGETS_DN": "Genes down-regulated in HB2 cells (mammary epithelium) upon expression of KDM5B [GeneID=10765] off an adenoviral vector.", "SEIDEN_ONCOGENESIS_BY_MET": "Genes changed in xenograft tumors formed by DLD-1 or DKO-4 cells (colon cancer) overexpressing MET [GeneID=4233].", "SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_DN": "Genes down-regulated in CT60/4 cells (breast cancer reverted to normal by transfer of chromosome 8p region) vs parental MDA-MB-231 cells (deleted chromosome 8p).", "SEKI_INFLAMMATORY_RESPONSE_LPS_DN": "Genes down-regulated in hepatic stellar cells after stimulation with bacterial lipopolysacharide (LPS).", "SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP": "Genes up-regulated in CT60/4 cells (breast cancer reverted to normal by transfer of chromosome 8p region) vs parental MDA-MB-231 cells (deleted chromosome 8p).", "SEMBA_FHIT_TARGETS_DN": "Genes down-regulated in H1299 cells (non-small cell lung cancer, NSCLC) expressing the Y144F mutant form of FHIT [GeneID=2272].", "SEKI_INFLAMMATORY_RESPONSE_LPS_UP": "Genes up-regulated in hepatic stellar cells after stimulation with bacterial lipopolysacharide (LPS).", "SEMBA_FHIT_TARGETS_UP": "Genes up-regulated in H1299 cells (non-small cell lung cancer, NSCLC) expressing the Y144F mutant form of FHIT [GeneID=2272].", "SEMENZA_HIF1_TARGETS": "Genes that are transcriptionally regulated by HIF1A [GeneID=3091].", "SENESE_HDAC1_AND_HDAC2_TARGETS_UP": "Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi.", "SENESE_HDAC1_AND_HDAC2_TARGETS_DN": "Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi.", "SENESE_HDAC2_TARGETS_UP": "Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC2 [GeneID=3066] by RNAi.", "SENESE_HDAC2_TARGETS_DN": "Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC2 [GeneID=3066] by RNAi.", "SENESE_HDAC1_TARGETS_DN": "Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [GeneID=3065] by RNAi.", "SENESE_HDAC1_TARGETS_UP": "Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [GeneID=3065] by RNAi.", "SENESE_HDAC3_TARGETS_UP": "Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC3 [GeneID=8841] by RNAi.", "SENGUPTA_EBNA1_ANTICORRELATED": "Genes whose reduced expression in nasopharyngeal carinoma (NPC) correlated most with the increased expression of EBNA1 [GeneID=3783774], a latent gene of Epstein-Barr virus (EBV).", "SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN": "Genes down-regulated in nsopharyngeal carcinoma relative to the normal tissue.", "SENESE_HDAC3_TARGETS_DN": "Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC3 [GeneID=8841] by RNAi.", "SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN": "Genes down-regulated in nasopharyngeal carcinoma (NPC) positive for LMP1 [GeneID=9260], a latent gene of Epstein-Barr virus (EBV).", "SERVITJA_ISLET_HNF1A_TARGETS_DN": "Genes down-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927].", "SERVITJA_ISLET_HNF1A_TARGETS_UP": "Genes up-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927].", "SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP": "Genes up-regulated in nsopharyngeal carcinoma relative to the normal tissue.", "SERVITJA_LIVER_HNF1A_TARGETS_DN": "Genes down-regulated in liver tissue upon knockout of HNF1A [GeneID=6927].", "SESTO_RESPONSE_TO_UV_C0": "Cluster 0: genes changed in primary keratinocytes by UVB irradiation.", "SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP": "Genes up-regulated in nasopharyngeal carcinoma (NPC) positive for LMP1 [GeneID=9260], a latent gene of Epstein-Barr virus (EBV).", "SESTO_RESPONSE_TO_UV_C1": "Cluster 1: genes changed in primary keratinocytes by UVB irradiation.", "SERVITJA_LIVER_HNF1A_TARGETS_UP": "Genes up-regulated in liver tissue upon knockout of HNF1A [GeneID=6927].", "SESTO_RESPONSE_TO_UV_C2": "Cluster 2: genes changed in primary keratinocytes by UVB irradiation.", "SESTO_RESPONSE_TO_UV_C3": "Cluster 3: genes changed in primary keratinocytes by UVB irradiation.", "SESTO_RESPONSE_TO_UV_C4": "Cluster 4: genes changed in primary keratinocytes by UVB irradiation.", "SESTO_RESPONSE_TO_UV_C5": "Cluster 5: genes changed in primary keratinocytes by UVB irradiation.", "SESTO_RESPONSE_TO_UV_C6": "Cluster 6: genes changed in primary keratinocytes by UVB irradiation.", "SESTO_RESPONSE_TO_UV_C7": "Cluster 7: genes changed in primary keratinocytes by UVB irradiation.", "SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_DN": "Genes down-regulated in prostate cancer samples bearing the fusion of TMPRSS2 with ERG [GeneID=7113;2078].", "SESTO_RESPONSE_TO_UV_C8": "Cluster 8: genes changed in primary keratinocytes by UVB irradiation.", "SHAFFER_IRF4_MULTIPLE_MYELOMA_PROGRAM": "Direct targets of IRF4 [GeneID=3662] that constitute a multiple myeloma program.", "SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_UP": "Genes up-regulated in prostate cancer samples bearing the fusion of TMPRSS2 with ERG [GeneID=7113;2078].", "SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE": "IRF4 [GeneID=3662] target genes induced after activation of primary B lymphocytes by anti-IgM crosslinking.", "SHAFFER_IRF4_TARGETS_IN_ACTIVATED_DENDRITIC_CELL": "IRF4 [GeneID=3662] target genes up-regulated in plasmacytoid dendritic cells compared to monocytes.", "SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE": "IRF4 [GeneID=3662] target genes up-regulated in plasma cells compared to mature B lymphocytes.", "SHANK_TAL1_TARGETS_DN": "Genes down-regulated in preleukemic thymocytes from transgenic mice which overexpress TAL1 [GeneID=6886] in thymus.", "SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE": "IRF4 [GeneID=3662] target genes up-regulated in primary myeloma vs. mature B lymphocytes.", "SHARMA_ASTROCYTOMA_WITH_NF1_SYNDROM": "Genes up-regulated in pilocytic astrocytoma (PA) samples from patients with type 1 neurofibromatosis syndrom (NF1) compared to the PA tumors from non-NF1 patients.", "SHARMA_PILOCYTIC_ASTROCYTOMA_LOCATION_DN": "Genes down-regulated in pilocytic astrocytoma (PA) from supratentorial regions compared to the infratentorial PA tumors.", "SHARMA_PILOCYTIC_ASTROCYTOMA_LOCATION_UP": "Genes up-regulated in pilocytic astrocytoma (PA) from supratentorial regions compared to the infratentorial PA tumors.", "SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5": "Cluster 5 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts good survival outcome.", "SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12": "Cluster 12 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts good survival outcome.", "SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6": "Cluster 6 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts poor survival outcome.", "SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4": "Cluster 4 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts good survival outcome.", "SHEPARD_BMYB_MORPHOLINO_DN": "Human orthologs of genes down-regulated in zebra fish after knockdown of BMYB [GeneID=4605] by morpholino.", "SHEPARD_BMYB_MORPHOLINO_UP": "Human orthologs of genes up-regulated in zebra fish after knockdown of BMYB [GeneID=4605] by morpholino.", "SHEN_SMARCA2_TARGETS_DN": "Genes whose expression negatively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples.", "SHEN_SMARCA2_TARGETS_UP": "Genes whose expression positively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples.", "SHEPARD_BMYB_TARGETS": "Human orthologs of BMYB [GeneID=4605] target genes in zebra fish, identified as commonly changed in the BMYB loss of function mutant crb ('crush and burn') and after knockdown of BMYB by morpholino.", "SHEPARD_CRASH_AND_BURN_MUTANT_DN": "Human orthologs of genes down-regulated in the crb ('crash and burn') zebrafish mutant that represents a loss-of-function mutation in BMYB [GeneID=4605].", "SHEPARD_CRASH_AND_BURN_MUTANT_UP": "Human orthologs of genes up-regulated in the crb ('crash and burn') zebrafish mutant that represents a loss-of-function mutation in BMYB [GeneID=4605].", "SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM3": "Cluster PAM3: genes most highly up-regulated in hepatocellular carcinoma (HCC) vs normal liver tissue from mice deficient for TXNIP [GeneID=10628].", "SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2": "Cluster PAM2: genes up-regulated in hepatocellular carcinoma (HCC) vs normal liver tissue from mice deficient for TXNIP [GeneID=10628].", "SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1": "Cluster PAM1: genes up-regulated in hepatocellular carcinoma (HCC) vs normal liver tissue from mice deficient for TXNIP [GeneID=10628].", "SHIN_B_CELL_LYMPHOMA_CLUSTER_1": "Cluster 1 of genes distinguishing among different B lymphocyte neoplasms.", "SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM6": "Cluster PAM6: genes changed exclusively in normal liver tissue adjacent to hepatocellular carcinoma (HCC) from mice deficient for TXNIP [GeneID=10628].", "SHIN_B_CELL_LYMPHOMA_CLUSTER_2": "Cluster 2 of genes distinguishing among different B lymphocyte neoplasms.", "SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5": "Cluster PAM5: genes changed exclusively in hepatocellular carcinoma (HCC) samples from 27 month old mice deficient for TXNIP [GeneID=10628].", "SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4": "Cluster PAM4: genes down-regulated in hepatocellular carcinoma (HCC) vs normal liver tissue from mice deficient for TXNIP [GeneID=10628].", "SHIN_B_CELL_LYMPHOMA_CLUSTER_3": "Cluster 3 of genes distinguishing  among different B lymphocyte neoplasms.", "SHIN_B_CELL_LYMPHOMA_CLUSTER_5": "Cluster 5 of genes distinguishing among different B lymphocyte neoplasms.", "SHIN_B_CELL_LYMPHOMA_CLUSTER_6": "Cluster 6 of genes distinguishing among different B lymphocyte neoplasms.", "SHIN_B_CELL_LYMPHOMA_CLUSTER_7": "Cluster 7 of genes distinguishing among different B lymphocyte neoplasms.", "SHIN_B_CELL_LYMPHOMA_CLUSTER_9": "Cluster 9 of genes distinguishing among different B lymphocyte neoplasms.", "SHIN_B_CELL_LYMPHOMA_CLUSTER_8": "Cluster 8 of genes distinguishing among different B lymphocyte neoplasms.", "SHIPP_DLBCL_CURED_VS_FATAL_DN": "Top 50 down-regulated markers for the diffused large B-cell lymphoma (DLBCL) that distinguished between cured and fatal/refractory clinical outcomes.", "SHIPP_DLBCL_CURED_VS_FATAL_UP": "Top 50 up-regulated markers for the diffused large B-cell lymphoma (DLBCL) that distinguished between cured and fatal/refractory clinical outcomes.", "SHIRAISHI_PLZF_TARGETS_DN": "Genes down-regulated in A375 and 397 cells (melanoma) by forced expression of PLZF [GeneID=7704] off adenovirus vector.", "SHIRAISHI_PLZF_TARGETS_UP": "Genes up-regulated in A375 and 397 cells (melanoma) by forced expression of PLZF [GeneID=7704] off adenovirus vector.", "SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP": "Top 50 up-regulated markers distinguishing diffuse large B-cell lymphoma (DLBCL) from follicular lymphoma (FL) samples.", "SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_DN": "Top 50 down-regulated markers distinguishing diffuse large B-cell lymphoma (DLBCL) from follicular lymphoma (FL) samples.", "SHI_SPARC_TARGETS_DN": "Genes down-regulated in glioma cell lines after knockdown of SPARC [GeneID=6678] by RNAi.", "SILIGAN_TARGETS_OF_EWS_FLI1_FUSION_DN": "Genes bound by EWSR1-FLT1 [GeneID=2130;2321] fusion and down-regulated in STA-ET-7.2 cells (Ewing's sarcoma) after knockdown of EWSR1-FLT1 by RNAi.", "SHI_SPARC_TARGETS_UP": "Genes up-regulated in glioma cell lines after knockdown of SPARC [GeneID=6678] by RNAi.", "SILIGAN_BOUND_BY_EWS_FLT1_FUSION": "Genes bound by EWSR1-FLT1 [GeneID=2130;2321] fusion but whose expression did not change in STA-ET-7.2 cells (Ewing's sarcoma) after knockdown of EWSR1-FLT1 by RNAi.", "SIMBULAN_PARP1_TARGETS_DN": "Genes down-regulated in MEF cells (embryonic fibroblasts) from PARP1 [GeneID=142] knockout mice.", "SILIGAN_TARGETS_OF_EWS_FLI1_FUSION_UP": "Genes bound by EWSR1-FLT1 [GeneID=2130;2321] fusion and up-regulated in STA-ET-7.2 cells (Ewing's sarcoma) after knockdown of EWSR1-FLT1 by RNAi.", "SIMBULAN_UV_RESPONSE_NORMAL_UP": "Genes up-regulated in HFK cells (primary keratinocytes) in response to UVB irradiation.", "SINGH_NFE2L2_TARGETS": "Selected electrophile and drug detoxication genes down-regulated in A549 and H460 cells (lung cancer) upon knockdown of NFE2L2 [GeneID=4780] by RNAi.", "SIMBULAN_UV_RESPONSE_IMMORTALIZED_DN": "Genes down-regulated in response to UVB radiation in HFK cells (keratinocytes) immortalized by overexpression of HPV E6 and E7 viral oncogenes.", "SIMBULAN_PARP1_TARGETS_UP": "Genes up-regulated in MEF cells (embryonic fibroblasts) from PARP1 [GeneID=142] knockout mice.", "SIMBULAN_UV_RESPONSE_NORMAL_DN": "Genes down-regulated in HFK cells (primary keratinocytes) in response to UVB irradiation.", "SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP": "Genes up-regulated in head and neck squamous cell carcinoma (HNSCC) samples positive for HPV compared to the HPV-negative tumors.", "SMID_BREAST_CANCER_ERBB2_DN": "Genes down-regulated in the erbb2 subype of breast cancer samples, characterized by higher expression of ERBB2 [GeneID=2064].", "SMID_BREAST_CANCER_ERBB2_UP": "Genes up-regulated in the erbb2 subype of breast cancer samples, characterized by higher expression of ERBB2 [GeneID=2064].", "SMID_BREAST_CANCER_LUMINAL_A_DN": "Genes down-regulated in the luminal A subtype of breast cancer.", "SMID_BREAST_CANCER_BASAL_UP": "Genes up-regulated in basal subtype of breast cancer samles.", "SMID_BREAST_CANCER_BASAL_DN": "Genes down-regulated in basal subtype of breast cancer samles.", "SMID_BREAST_CANCER_LUMINAL_A_UP": "Genes up-regulated in the luminal A subtype of breast cancer.", "SMID_BREAST_CANCER_NORMAL_LIKE_DN": "Genes down-regulated in the normal-like subtype of breast cancer.", "SMID_BREAST_CANCER_LUMINAL_B_UP": "Genes up-regulated in the luminal B subtype of breast cancer.", "SMID_BREAST_CANCER_LUMINAL_B_DN": "Genes down-regulated in the luminal B subtype of breast cancer.", "SMID_BREAST_CANCER_NORMAL_LIKE_UP": "Genes up-regulated in the normal-like subtype of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_UP": "Genes up-regulated in brain relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP": "Genes up-regulated in bone relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_DN": "Genes down-regulated in brain relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_LIVER_DN": "Genes down-regulated in liver relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN": "Genes down-regulated in bone relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_LIVER_UP": "Genes up-regulated in liver relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_LUNG_UP": "Genes up-regulated in lung relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_LUNG_DN": "Genes down-regulated in lung relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_PLEURA_DN": "Genes down-regulated in pleura relapse of breast cancer.", "SMID_BREAST_CANCER_RELAPSE_IN_PLEURA_UP": "Genes up-regulated in pleura relapse of breast cancer.", "SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_DN": "Genes down-regulated in circulating endothelial cells (CEC) from cancer patients compared to those from healthy donors.", "SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP": "Genes up-regulated in circulating endothelial cells (CEC) from cancer patients compared to those from healthy donors.", "SMIRNOV_RESPONSE_TO_IR_2HR_UP": "Genes up-regulated in B lymphocytes at 2 h after exprosure to 10 Gy dose of ionizing radiation.", "SMIRNOV_RESPONSE_TO_IR_2HR_DN": "Genes down-regulated in B lymphocytes at 2 h after exprosure to 10 Gy dose of ionizing radiation.", "SMITH_TERT_TARGETS_DN": "Genes consistently down-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [GeneID=7015] off a retroviral vector.", "SMITH_LIVER_CANCER": "Potential marker genes specifically up-regulated in the majority of hepatocellular carcinoma (HCC) tumors.", "SMIRNOV_RESPONSE_TO_IR_6HR_DN": "Genes down-regulated in B lymphocytes at 6 h after exprosure to 10 Gy dose of ionizing radiation.", "SMIRNOV_RESPONSE_TO_IR_6HR_UP": "Genes up-regulated in B lymphocytes at 6 h after exprosure to 10 Gy dose of ionizing radiation.", "SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TUMORS": "Genes from the recurrent amplicons in 89 samples of oral squamous cell carcinoma (SCC).", "SMITH_TERT_TARGETS_UP": "Genes consistently up-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [GeneID=7015] off a retroviral vector.", "SOGA_COLORECTAL_CANCER_MYC_DN": "Metabolic related genes that showed negative correlation with MYC expression in CRC tissues", "SOGA_COLORECTAL_CANCER_MYC_UP": "Metabolic related genes that showed positive correlation with MYC expression in CRC tissues", "SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_DN": "Down-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3.", "SONG_TARGETS_OF_IE86_CMV_PROTEIN": "Cellular genes up-regulated in forskin fibroblasts by expression of CMV EI86 protein off an adenovirus vector.", "SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_DN": "Genes down-regulated more than two-fold in lymphoblastoid cell lines from European population compared to those from Asian population.", "SOUCEK_MYC_TARGETS": "Chemokine genes up-regulated within 2 hr of c-Myc [GeneID=4609] activation in a mouse model of Myc-induced pancreatic beta-cell tumorigenesis.", "SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_UP": "Genes up-regulated more than two-fold in lymphoblastoid cell lines from European population compared to those from Asian population.", "SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP": "Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3.", "SPIRA_SMOKERS_LUNG_CANCER_UP": "Up-regulated genes that distinguished smokers with and without lung cancer.", "SPIRA_SMOKERS_LUNG_CANCER_DN": "Down-regulated genes that distinguished smokers with and without lung cancer.", "STAMBOLSKY_BOUND_BY_MUTATED_TP53": "Gene promoters preferentially bound by a mutated form of TP53 [GeneID=7157] in SKBR3 cells (breast cancer).", "SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN": "Genes down-regulated in lymphoblastoid cells from the European population compared to those from the Asian population.", "STAMBOLSKY_RESPONSE_TO_VITAMIN_D3_DN": "Genes repressed in SKBR3 cells (breast cancer) by 25-hydroxyvitamin D3 [PubChem=1593].", "STAEGE_EWING_FAMILY_TUMOR": "Genes up-regulated in Ewing family tumors (EFT) compared with normal bone marrow samples.", "STAMBOLSKY_RESPONSE_TO_VITAMIN_D3_UP": "Genes induced in SKBR3 cells (breast cancer) by 25-hydroxyvitamin D3 [PubChem=1593].", "STAMBOLSKY_TARGETS_OF_MUTATED_TP53_DN": "Genes repressed in SKBR3 cells (breast cancer) by mutated TP53 [GeneID=7157].", "SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP": "Genes up-regulated in lymphoblastoid cells from the European population compared to those from the Asian population.", "STAMBOLSKY_TARGETS_OF_MUTATED_TP53_UP": "Genes induced in SKBR3 cells (breast cancer) by mutated TP53 [GeneID=7157].", "STANHILL_HRAS_TRANSFROMATION_UP": "Selected genes up-regulated in Rat1Ras cells (fibroblasts) which were transformed by expression of an oncogenic activated form of HRAS [GeneID=3265] compared to the parental Rat1 cells.", "STANELLE_E2F1_TARGETS": "Genes up-regulated by induction of E2F1 expression in Saos2 (osteosarcoma) cells.", "STARK_BRAIN_22Q11_DELETION": "Genes located outside the microdeletion region in 22q11 which were differentially expressed in the same manner both in hyppocampus and prefrontal cortex.", "STARK_HYPPOCAMPUS_22Q11_DELETION_DN": "Genes down-regulated in hyppocampus of mice carrying a hemizygotic microdeletion in the 22q11.2 region.", "STARK_HYPPOCAMPUS_22Q11_DELETION_UP": "Genes up-regulated in hyppocampus of mice carrying a hemizygotic microdeletion in the 22q11.2 region.", "STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN": "Down-regulated genes classifying non-tumor lung tissues by age after incution of lung cancer by urethane injection [PubChem=5641]: early (24-26 weeks) vs late (46 weeks).", "STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP": "Genes up-regulated in prefrontal cortex (PFC) of mice carrying a hemizygotic microdeletion in the 22q11.2 region.", "STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP": "Up-regulated genes classifying non-tumor lung tissues by age after incution of lung cancer by urethane injection [PubChem=5641]: early (24-26 weeks) vs late (46 weeks).", "STEARMAN_TUMOR_FIELD_EFFECT_UP": "Up-regulated genes in the 'Field Effect' signature of normal lung tissue adjacent to the tumor.", "STEGER_ADIPOGENESIS_UP": "Genes up-regulated during adipogenesis of 3T3-L1 cells (fibroblast).", "STEGER_ADIPOGENESIS_DN": "Genes down-regulated during adipogenesis of 3T3-L1 cells (fibroblast).", "STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN": "Genes down-regulated in prefrontal cortex (PFC) of mice carrying a hemizygotic microdeletion in the 22q11.2 region.", "STEINER_ERYTHROCYTE_MEMBRANE_GENES": "Major erythrocyte membrane genes.", "STEGMEIER_PREMITOTIC_CELL_CYCLE_REGULATORS": "Pre-mitotic cell cycle regulators (CDC) identified in an shRNA screen of the ubiquitin pathway components.", "STEIN_ESR1_TARGETS": "Genes regulated by ESR1 [GeneID=2099] in MCF-7 cells (breast cancer).", "STEIN_ESRRA_TARGETS_DN": "Genes down-regulated by ESRRA [GeneID=2101] only.", "STEIN_ESTROGEN_RESPONSE_NOT_VIA_ESRRA": "Genes up-regulated by estradiol [PubChem=5757] and not modulated by ESRRA [GeneID=2101] in MCF-7 cells (breast cancer).", "STONER_ESOPHAGEAL_CARCINOGENESIS_DN": "Genes down-regulated in esophagus by the carcinogen NMBA [PubChem=13643] and brought back to normal by a diet with PEITC [PubChem=16741] or black raspberries.", "STEIN_ESRRA_TARGETS_RESPONSIVE_TO_ESTROGEN_DN": "Genes down-regulated by estradiol [PubChem=5757] and down-regulated by ESRRA [GeneID=2101] in MCF-7 cells (breast cancer).", "STEIN_ESRRA_TARGETS_RESPONSIVE_TO_ESTROGEN_UP": "Genes up-regulated by estradiol [PubChem=5757] and up-regulated by ESRRA [GeneID=2101] in MCF-7 cells (breast cancer).", "STEIN_ESRRA_TARGETS": "Genes regulated by ESRRA [GeneID=2101] in MCF-7 cells (breast cancer).", "STOSSI_RESPONSE_TO_ESTRADIOL": "Genes up-regulated by estradiol (E2) [PubChem=5757] in U2OS cells (osteosarcoma) expressing ESR1 or ESR2 [GeneID=2099;2100].", "STONER_ESOPHAGEAL_CARCINOGENESIS_UP": "Genes up-regulated in esophagus by the carcinogen NMBA [PubChem=13643] and brought back to normal by a diet with PEITC [PubChem=16741] or black raspberries.", "STREICHER_LSM1_TARGETS_DN": "Genes down-regulated in MCF10A cells (breast cancer) by expression of LSM1 [GeneID=27257] off a letiviral vector.", "STEIN_ESRRA_TARGETS_UP": "Genes up-regulated by ESRRA [GeneID=2101] only.", "STREICHER_LSM1_TARGETS_UP": "Genes up-regulated in MCF10A cells (breast cancer) by expression of LSM1 [GeneID=27257] off a letiviral vector.", "SUMI_HNF4A_TARGETS": "Genes up-regulated in HepG2 cells (hepatocellular carcinoma, HCC) upon expression of HNF4A [GeneID=3172] and down-regulated upon knockdown of HNF4A [GeneID=3172] in these cells by RNAi.", "SUH_COEXPRESSED_WITH_ID1_AND_ID2_UP": "Genes whose expression positively correlates with that of both ID1 and ID2 [GeneID=3397;3398] genes in a cohort of 285 patients with primaly AML (acule myelogenous leukemia) [PMID=15084694].", "SUBTIL_PROGESTIN_TARGETS": "Genes responding to progestin R5020 [PubChem=36709] treatment of T47D-MTVL cells (breast cancer).", "SUNG_METASTASIS_STROMA_DN": "Genes down-regulated in metastatic vs non-metastatic stromal cells originated from either bone or prostate tissues.", "SUNG_METASTASIS_STROMA_UP": "Genes up-regulated in metastatic vs non-metastatic stromal cells originated from either bone or prostate tissues.", "SUZUKI_AMPLIFIED_IN_ORAL_CANCER": "High-level amplifications detected in oral squamous cell carcinoma (OSCC) lines by array-CGH analysis.", "SUZUKI_CTCFL_TARGETS_UP": "Genes up-regulated in testis tissue upon knockout of CTCFL [GeneID=140690].", "SUZUKI_RESPONSE_TO_TSA": "Genes up-regulated by TSA alone [PubChem=5562], with non-hypermethylated promoters, in RKO cells (colorectal cancer).", "SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1B": "Genes with some basal expression and partially methylated promoters, up-regulated by the combination of TSA and decitabine [PubChem=5562;451668] in RKO cells (colorectal cancer).", "SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1A": "Genes basally silent, with hypermethylated promoters, up-regulated by the combination of TSA and decitabine [PubChem=5562;451668] in RKO cells (colorectal cancer).", "SU_KIDNEY": "Genes up-regulated specifically in human kidney tissue.", "SU_LIVER": "Genes up-regulated specifically in human liver tissue.", "SU_PANCREAS": "Genes up-regulated specifically in human pancreas.", "SU_SALIVARY_GLAND": "Genes up-regulated specifically in human salivary gland tissue.", "SU_PLACENTA": "Genes up-regulated specifically in human placenta.", "SU_TESTIS": "Genes up-regulated specifically in human testis tissue.", "SU_THYMUS": "Genes up-regulated specifically in human thymus.", "SWEET_KRAS_ONCOGENIC_SIGNATURE": "Genes that contributed maximally to the GSEA score of the up-regulated gene set from the KrasLA mouse model in two human lung cancer expression data sets comparing mutant vs normal KRAS [GeneID=3845].", "SWEET_KRAS_TARGETS_DN": "Genes upregulated in control vs KRAS [GeneID=3845] knockdown in a human cell line.", "SWEET_KRAS_TARGETS_UP": "Genes upregulated in KRAS [GeneID=3845] knockdown vs control in a human cell line.", "TAKADA_GASTRIC_CANCER_COPY_NUMBER_UP": "Candidate genes in the regions of copy number gain in gastric cancer cell lines.", "TAGHAVI_NEOPLASTIC_TRANSFORMATION": "Genes that cooperate with MYC and TBX2 [GeneID=4609;6909] to transform MEF cells (embryo fibroblasts).", "SWEET_LUNG_CANCER_KRAS_DN": "Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845].", "SYED_ESTRADIOL_RESPONSE": "Genes responsive to estradiol [PubChem=5757] both in normal and cancer ovarian cell lines.", "TAKADA_GASTRIC_CANCER_COPY_NUMBER_DN": "Candidate genes in the regions of copy number loss in gastric cancer cell lines.", "TAKAO_RESPONSE_TO_UVB_RADIATION_DN": "Genes down-regulated in primary tissue culture of epidermal kerationcytes after UVB irradiation.", "TAKAYAMA_BOUND_BY_AR": "Genes whose promoters bound AR [GeneID=367] in LNCaP cells (prostate cancer) after exposure to the synthetic androgen R1881 [PubChem=13766], based on ChIP-chip analysis.", "TAKAO_RESPONSE_TO_UVB_RADIATION_UP": "Genes up-regulated in primary tissue culture of epidermal kerationcytes after UVB irradiation.", "SWEET_LUNG_CANCER_KRAS_UP": "Genes up-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845].", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN": "Genes down-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 10 days after transduction.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP": "Genes up-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 10 days after transduction.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN": "Genes down-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 3 days after transduction.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN": "Genes down-rgulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 6h.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN": "Genes down-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 16 days after transduction.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP": "Genes up-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 16 days after transduction.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP": "Genes up-rgulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 6h.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP": "Genes up-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 3 days after transduction.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN": "Genes down-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 8 days after transduction.", "TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA": "Genes with hypermethylated DNA in all four esophageal squamous cell carcinoma (ESCC) lines analyzed.", "TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP": "Genes up-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 8 days after transduction.", "TANG_SENESCENCE_TP53_TARGETS_DN": "Genes down-regulated in WI-38 cells (senescent primary fibroblasts) after inactivation of TP53 [GeneID=7157] by GSE56 polypeptide.", "TANG_SENESCENCE_TP53_TARGETS_UP": "Genes up-regulated in WI-38 cells (senescent primary fibroblasts) after inactivation of TP53 [GeneID=7157] by GSE56 polypeptide.", "TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN": "Genes down-regulated in plasma cells compared with B lymphocytes.", "TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_UP": "Genes up-regulated in plasma cells compared with B lymphocytes.", "TAVAZOIE_METASTASIS": "Putative metastasis genes: up-regulated in metastatic cell lines LM2 (lung) and BoM2 (bone) relative to the parental MDA-MB-231 line (breast adenocarcinoma).", "TAVOR_CEBPA_TARGETS_DN": "Genes down-regulated in KCL22 cells (chronic myelogenous leukemia, CML, with BCR-ABL1 [GeneID=613;25] fusion) by expression of CEBPA [GeneID=1050].", "TAVOR_CEBPA_TARGETS_UP": "Genes up-regulated in KCL22 cells (chronic myelogenous leukemia, CML, with BCR-ABL1 [GeneID=613;25] fusion) by expression of CEBPA [GeneID=1050].", "TAYLOR_METHYLATED_IN_ACUTE_LYMPHOBLASTIC_LEUKEMIA": "Genes whose DNA methylation differed between primary ALL cells (acute lymphoblastic leukemia) and normal peripheral blood samples.", "TARTE_PLASMA_CELL_VS_PLASMABLAST_DN": "Genes down-regulated in mature plasma cells compared with plasmablastic B lymphocytes.", "TCGA_GLIOBLASTOMA_COPY_NUMBER_DN": "Genes down-regulated and displaying decreased copy number in glioblastoma samples.", "TARTE_PLASMA_CELL_VS_PLASMABLAST_UP": "Genes up-regulated in mature plasma cells compared with plasmablastic B lymphocytes.", "TCGA_GLIOBLASTOMA_COPY_NUMBER_UP": "Genes up-regulated and displaying increased copy number in glioblastoma samples.", "TCGA_GLIOBLASTOMA_MUTATED": "Genes significantly mutated in 91 glioblastoma samples.", "TENEDINI_MEGAKARYOCYTE_MARKERS": "Genes essential to the development of megakaryocytes, as expressed in normal cells and essential thrombocythemic cells (ET).", "TERAMOTO_OPN_TARGETS_CLUSTER_1": "Cluster 1: genes whose up-regulation peaked one day after knockdown of OPN [GeneID=6696] by RNAi in the NIH3T3 cells (fibroblasts) transformed by activated HRAS [GeneID=3265].", "TERAMOTO_OPN_TARGETS_CLUSTER_3": "Cluster 3: genes whose up-regulation peaked 3 days after knockdown of OPN [GeneID=6696] by RNAi in the NIH3T3 cells (fibroblasts) transformed by activated HRAS [GeneID=3265].", "TERAMOTO_OPN_TARGETS_CLUSTER_5": "Cluster 5: genes whose up-regulation peaked 5 days after knockdown of OPN [GeneID=6696] by RNAi in the NIH3T3 cells (fibroblasts) transformed by activated HRAS [GeneID=3265].", "TERAMOTO_OPN_TARGETS_CLUSTER_4": "Cluster 4: genes whose up-regulation peaked 4 days after knockdown of OPN [GeneID=6696] by RNAi in the NIH3T3 cells (fibroblasts) transformed by activated HRAS [GeneID=3265].", "TERAMOTO_OPN_TARGETS_CLUSTER_7": "Cluster 7: genes down-regulated early (within 24 h) after knockdown of OPN [GeneID=6696] by RNAi in the NIH3T3 cells (fibroblasts) transformed by activated HRAS [GeneID=3265].", "TERAMOTO_OPN_TARGETS_CLUSTER_8": "Cluster 8: genes showing sustained pattern of down-regulation after knockdown of OPN [GeneID=6696] by RNAi in the NIH3T3 cells (fibroblasts) transformed by activated HRAS [GeneID=3265].", "TERAMOTO_OPN_TARGETS_CLUSTER_6": "Cluster 6:  genes exhibiting prolonged up-regulation (>72 h) after knockdown of OPN [GeneID=6696] by RNAi in the NIH3T3 cells (fibroblasts) transformed by activated HRAS [GeneID=3265].", "TERAO_AOX4_TARGETS_HG_DN": "Genes down-regulated in Harderian gland tissue upon knockout of AOX4 [GeneID=71872].", "TERAO_AOX4_TARGETS_HG_UP": "Genes up-regulated in Harderian gland tissue upon knockout of AOX4 [GeneID=71872].", "TESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_DN": "Genes down-regulated in mES cells (mouse embryonic stem cells) after tratment with the ALK [GeneID=238] inhibitor SB-431542 and JAK inhibitor I [PubChem=4521392;5494425].", "TERAO_AOX4_TARGETS_SKIN_DN": "Genes down-regulated in skin upon knockout of AOX4 [GeneID=71872].", "TERAO_AOX4_TARGETS_SKIN_UP": "Genes up-regulated in skin upon knockout of AOX4 [GeneID=71872].", "TESAR_ALK_TARGETS_EPISC_3D_UP": "Genes up-regulated in EpiSC cells (mouse epiblast embryonic stem cells) after treatment with the ALK [GeneID=238] inhibitor SB-431542 [PubChem=4521392].", "TESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_UP": "Genes up-regulated in mES cells (mouse embryonic stem cells) after tratment with the ALK [GeneID=238] inhibitor SB-431542 and JAK inhibitor I [PubChem=4521392;5494425].", "TESAR_ALK_TARGETS_HUMAN_ES_4D_DN": "Genes down-regulated in hES cells (human embryonic stem cells) after treatment with the ALK [GeneID=238] inhibitor SB-431542 [PubChem=16079008].", "TESAR_ALK_TARGETS_HUMAN_ES_5D_UP": "Genes up-regulated in hES cells (human embryonic stem cells) after treatment with the ALK [GeneID=238] inhibitor SB-431542 [PubChem=4521392].", "TESAR_ALK_TARGETS_EPISC_4D_UP": "Genes up-regulated in EpiSC cells (epiblast stem cells) after treatment with the ALK [GeneID=238] inhibitor SB-431542 [PubChem=4521392].", "TESAR_ALK_TARGETS_HUMAN_ES_5D_DN": "Genes down-regulated in hES cells (human embryonic stem cells) after treatment with the ALK [GeneID=238] inhibitor SB-431542 [PubChem=4521392].", "TESAR_JAK_TARGETS_MOUSE_ES_D3_DN": "Genes down-regulated in mES cells (mouse embryonic stem cells) after tratment with JAK inhibitor I [PubChem=5494425].", "THEODOROU_MAMMARY_TUMORIGENESIS": "Candidate mammary tumorigenesis genes from the common insertion sites (CIS) of MMTV virus that induced breast tumors in mice.", "THILLAINADESAN_ZNF217_TARGETS_DN": "Genes bound and repressed by ZNF217 [GeneID=7764] in MCF7 cells (breast cancer).", "THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP": "Genes up-regulated in polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds.", "THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN": "Genes down-regulated in polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds.", "THILLAINADESAN_ZNF217_TARGETS_UP": "Genes bound and activated by ZNF217 [GeneID=7764] in MCF7 cells (breast cancer).", "THUM_MIR21_TARGETS_HEART_DISEASE_UP": "Genes up-regulated in a mouse model of heart disease whose expression reverted to normal by silencing of MIR21 [GeneID=406991] microRNA.", "THUM_MIR21_TARGETS_HEART_DISEASE_DN": "Genes down-regulated in a mouse model of heart disease whose expression reverted to normal by silencing of MIR21 [GeneID=406991] microRNA.", "TIAN_BHLHA15_TARGETS": "Genes up-regulated in both AGS and HGC-27 cells (gastric cancer) by BHLHA15 [GeneID=168620] transfection.", "TIAN_TNF_SIGNALING_NOT_VIA_NFKB": "Genes modulated in HeLa cells (cervical carcinoma) by TNF [GeneID=7124] not via NFKB pathway.", "THUM_SYSTOLIC_HEART_FAILURE_DN": "Genes down-regulated in samples with systolic heart failure compared to normal hearts.", "TIAN_TNF_SIGNALING_VIA_NFKB": "Genes modulated in HeLa cells (cervical carcinoma) by TNF [GeneID=7124] via NFKB pathway.", "THUM_SYSTOLIC_HEART_FAILURE_UP": "Genes up-regulated in samples with systolic heart failure compared to normal hearts.", "TIEN_INTESTINE_PROBIOTICS_2HR_DN": "Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 2h.", "TIEN_INTESTINE_PROBIOTICS_24HR_DN": "Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h.", "TIEN_INTESTINE_PROBIOTICS_2HR_UP": "Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 2h.", "TIEN_INTESTINE_PROBIOTICS_6HR_UP": "Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 6h.", "TIEN_INTESTINE_PROBIOTICS_6HR_DN": "Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 6h.", "TIMOFEEVA_GROWTH_STRESS_VIA_STAT1_DN": "Genes down-regulated in SK-NEP-1 cells (Wilm's tumor ) stably expressing inactivated forms of STAT1 [GeneID=6772] under growth stress (hypoxia or nutritional deprivation).", "TIEN_INTESTINE_PROBIOTICS_24HR_UP": "Genes up-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h.", "TOMIDA_LUNG_CANCER_POOR_SURVIVAL": "Metastatic signature genes that best distinguished between favorable and unfavorable prognosis for the non-small cell lung cancer (NSCLC) patients.", "TOMIDA_METASTASIS_DN": "Down-regulated genes associated with the acquision of metastatic potential in LNM35 cells (large cell lung cancer).", "TING_SILENCED_BY_DICER": "Epigenetically silenced genes up-regulated in HCT116 cells (colon cancer) hypomorphic for DICER1 [GeneID=23405].", "TOMIDA_METASTASIS_UP": "Up-regulated genes associated with the acquision of metastatic potential in LNM35 cells (large cell lung cancer).", "TOMLINS_METASTASIS_DN": "Top genes down-regulated in hormone refractory metastatic prostate cancer compared to localized prostate cancer.", "TOMLINS_METASTASIS_UP": "Top genes up-regulated in hormone refractory metastatic prostate cancer compared to localized prostate cancer.", "TOMLINS_PROSTATE_CANCER_DN": "Genes down-regulated in prostate cancer vs benign prostate tissue, based on a meta-analysis of five gene expression profiling studies.", "TOMLINS_PROSTATE_CANCER_UP": "Genes up-regulated in prostate cancer vs benign prostate tissue, based on a meta-analysis of five gene expression profiling studies.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_DN": "Genes down-regulated in erythroid lineage cells by RUNX1-RUNX1T1 [GeneID=861;862] fusion .", "TONG_INTERACT_WITH_PTTG1": "Proteins that interact with PTTG1 [GeneID=9232], based on protein array.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_GRANULOCYTE_DN": "Genes down-regulated in granulocytes by RUNX1-RUNX1T1 [GeneID=861;862] fusion.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP": "Genes up-regulated in erythroid lineage cells by RUNX1-RUNX1T1 [GeneID=861;862] fusion .", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_GRANULOCYTE_UP": "Genes up-regulated in granulocytes by RUNX1-RUNX1T1 [GeneID=861;862] fusion.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN": "Genes down-regulated in monocytes by RUNX1-RUNX1T1 [GeneID=861;862] fusion.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN": "Genes down-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [GeneID=861;862] fusion.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_GRANULOCYTE_DN": "Genes down-regulated by RUNX1-RUNX1T1 [GeneID=861;862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing granulocytes.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP": "Genes up-regulated in monocytes by RUNX1-RUNX1T1 [GeneID=861;862] fusion.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP": "Genes up-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [GeneID=861;862] fusion.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP": "Genes up-regulated by RUNX1-RUNX1T1 [GeneID=861;862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing erythroid lineage.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_MONOCYTE_DN": "Genes down-regulated by RUNX1-RUNX1T1 [GeneID=861;862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing monocytes.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_GRANULOCYTE_UP": "Genes up-regulated by RUNX1-RUNX1T1 [GeneID=861;862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing granulocytes.", "TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_MONOCYTE_UP": "Genes up-regulated by RUNX1-RUNX1T1 [GeneID=861;862] fusion protein in normal hematopoietic progenitors; their expression was sustained in subsequently developing monocytes.", "TOOKER_GEMCITABINE_RESISTANCE_DN": "Down-regulated genes in Calu3 cells (non-small cell lung cancer, NSCLC) resistant to gemcitabine [PubChem=3461] which became up-regulated in response to bexarotene [PubChem=82146].", "TOOKER_GEMCITABINE_RESISTANCE_UP": "Up-regulated genes in Calu3 cells (non-small cell lung cancer, NSCLC) resistant to gemcitabine [PubChem=3461] which became down-regulated in response to bexarotene [PubChem=82146].", "TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_TOP20_DN": "Top 20 down-regulated genes in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130] [GeneID=2313] compared to normal hematopoetic progenitors.", "TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_TOP20_UP": "Top 20 up-regulated genes in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130] [GeneID=2313] compared to normal hematopoetic progenitors.", "TRAYNOR_RETT_SYNDROM_DN": "Genes down-regulated in primary fibroblasts from Rett syndrom patients who carry mutations inactivating MECP2 [GeneID=4204].", "TSAI_DNAJB4_TARGETS_DN": "Genes down-regulated in CL1-5 cells (lung cancer) overexpressing DNAJB4 [GeneID=11080] off a plasmid vector.", "TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN": "Genes down-regulated in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130] [GeneID=2313] compared to normal hematopoetic progenitors.", "TRAYNOR_RETT_SYNDROM_UP": "Genes up-regulated in primary fibroblasts from Rett syndrom patients who carry mutations inactivating MECP2 [GeneID=4204].", "TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP": "Genes up-regulated in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130] [GeneID=2313] compared to normal hematopoetic progenitors.", "TSAI_DNAJB4_TARGETS_UP": "Genes up-regulated in CL1-5 cells (lung cancer) overexpressing DNAJB4 [GeneID=11080] off a plasmid vector.", "TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C": "Genes down-regulated in HCT116 cells (colon cancer) upon expression of MIR34B or MIR34C [GeneID=407041;407042] microRNAs.", "TSAI_RESPONSE_TO_RADIATION_THERAPY": "Genes up-regulated in response to both single dose and fractionated radiation that were common to all three cell lines studied.", "TSENG_ADIPOGENIC_POTENTIAL_DN": "Genes showing decreasing expression in brown preadipocytes with increasing ability of the cells to differentiate.", "TSUDA_ALVEOLAR_SOFT_PART_SARCOMA": "Protein kinase genes most significantly up-regulated in ASPS (alveolar soft part sarcoma) tumors compared to four other types of primitive sarcomas.", "TSENG_ADIPOGENIC_POTENTIAL_UP": "Genes showing increasing expression in brown preadipocytes with decreasing ability of the cells to differentiate.", "TSUNODA_CISPLATIN_RESISTANCE_UP": "Genes up-regulated in bladder cancer cells resistant to cisplatin [PubChem=2767] compared to the parental cells sensitive to the drug.", "TSAI_RESPONSE_TO_IONIZING_RADIATION": "Genes up-regulated in TK6, WTK1, and NH32 cell lines (lymphoblast) in response to ionizing radiation.", "TSENG_IRS1_TARGETS_UP": "Up-regulated in brown preadipocytes with IRS1 [GeneID=3667] knockout vs wild type controls; the knockouts have severe defects in adipocyte differentiation.", "TSENG_IRS1_TARGETS_DN": "Down-regulated in brown preadipocytes with IRS1 [GeneID=3667] knockout vs wild type controls; the knockouts have severe defects in adipocyte differentiation.", "TSUNODA_CISPLATIN_RESISTANCE_DN": "Genes down-regulated in bladder cancer cells resistant to cisplatin [PubChem=2767] compared to the parental cells sensitive to the drug.", "TSUTSUMI_FBXW8_TARGETS": "Genes differentially expressed in E18.5 whole embryos upon knockout of FBXW8 [GeneID=26259].", "TURASHVILI_BREAST_CARCINOMA_DUCTAL_VS_LOBULAR_DN": "Genes down-regulated in ductal vs lobular carcinoma breast tumor cells.", "TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_UP": "Genes up-regulated in small intestine tissue from transgenic mice expressing a mutant form of COL13A1 [GeneID=1305], compared to normal controls.", "TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_DN": "Genes down-regulated in small intestine tissue from transgenic mice expressing a mutant form of COL13A1 [GeneID=1305], compared to normal controls.", "TURASHVILI_BREAST_CARCINOMA_DUCTAL_VS_LOBULAR_UP": "Genes up-regulated in ductal vs lobular carcinoma breast tumor cells.", "TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_UP": "Genes up-regulated in ductal carcinoma vs normal ductal breast cells.", "TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_DN": "Genes down-regulated in ductal carcinoma vs normal lobular breast cells.", "TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_UP": "Genes up-regulated in ductal carcinoma vs normal lobular breast cells.", "TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_DN": "Genes down-regulated in lobular carcinoma vs normal ductal breast cells.", "TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN": "Genes down-regulated in ductal carcinoma vs normal ductal breast cells.", "TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP": "Genes up-regulated in lobular carcinoma vs normal ductal breast cells.", "TURASHVILI_BREAST_NORMAL_DUCTAL_VS_LOBULAR_DN": "Genes down-regulated in normal ductal and normal lobular breast cells.", "TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN": "Genes down-regulated in lobular carcinoma vs normal lobular breast cells.", "TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP": "Genes up-regulated in lobular carcinoma vs normal lobular breast cells.", "TURJANSKI_MAPK11_TARGETS": "Examples of transcription factors whose activities are regulated by MAPK11 [GeneID=5600] phosphorylation.", "TURASHVILI_BREAST_NORMAL_DUCTAL_VS_LOBULAR_UP": "Genes up-regulated in normal ductal and normal lobular breast cells.", "TURJANSKI_MAPK14_TARGETS": "Examples of transcription factors whose activities are regulated by MAPK14 [GeneID=1432] phosphorylation.", "TURJANSKI_MAPK1_AND_MAPK2_TARGETS": "Examples of transcription factors whose activities are regulated by MAPK1 and MAPK3 [GeneID=5594;5595] phosphorylation.", "TURJANSKI_MAPK8_AND_MAPK9_TARGETS": "Examples of transcription factors whose activities are regulated by MAPK8 and MAPK9 [GeneID=5599;5601].", "TURJANSKI_MAPK7_TARGETS": "Examples of transcription factors whose activities are regulated by MAPK7 [GeneID=5598] phosphorylation.", "UEDA_CENTRAL_CLOCK": "Molecular timetable composed of 96 time-indicating genes (103 probes) in the central (suprachiasmatic nucleus (SCN)) clock.", "UDAYAKUMAR_MED1_TARGETS_UP": "Genes up-regulated in HeLa cells after knockdown of MED1 [GeneID=5469] by RNAi.", "UDAYAKUMAR_MED1_TARGETS_DN": "Genes down-regulated in HeLa cells after knockdown of MED1 [GeneID=5469] by RNAi.", "UNTERMAN_IPF_VS_CTRL_CD4T_DN": "Genes downregulated in CD4 T-cells from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "ULE_SPLICING_VIA_NOVA2": "Genes whose splicing in neocortex was most affected by knock out of NOVA2 [GeneID=4858].", "UEDA_PERIFERAL_CLOCK": "Molecular timetable composed of 162 time-indicating genes (182 probes) in the peripheral (liver) clock.", "UNTERMAN_IPF_VS_CTRL_B_CELL_DN": "Genes downregulated in B cells from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_IPF_VS_CTRL_CD8T_DN": "Genes downregulated in CD8 T-cells from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_IPF_VS_CTRL_DC_DN": "Genes downregulated in Dendritic cells from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_IPF_VS_CTRL_CD8T_UP": "Genes upregulated in C84 T-cells from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_IPF_VS_CTRL_DC_UP": "Genes upregulated in Dendritic cells from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_IPF_VS_CTRL_MONOCYTE_UP": "Genes upregulated in Monocytes from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_IPF_VS_CTRL_MONOCYTE_DN": "Genes downregulated in Monocytes from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_IPF_VS_CTRL_NK_CELL_UP": "Genes upregulated in NK cells from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_IPF_VS_CTRL_NK_CELL_DN": "Genes downregulated in NK cells from Idiopathic Pulmonary Fibrosis Patients vs. Controls", "UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_CD8T_DN": "Genes downregulated in CD8 T-cells from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors", "UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_B_CELL_DN": "Genes downregulated in B cells from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors", "UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_CD8T_UP": "Genes upregulated in C84 T-cells from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors", "UNTERMAN_IPF_VS_CTRL_TREG_CELL_UP": "Genes upregulated in Treg cells from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors", "UNTERMAN_IPF_VS_CTRL_TREG_CELL_DN": "Genes downregulated in Treg cells from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors", "UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_NK_CELL_DN": "Genes downregulated in NK cells from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors", "UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_NK_CELL_UP": "Genes upregulated in NK cells from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors", "UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_MONOCYTE_DN": "Genes downregulated in Monocytes from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors", "UROSEVIC_RESPONSE_TO_IMIQUIMOD": "Interferon cluster genes up-regulated in skin tumors treated with imiquimod [PubChem=57469].", "URS_ADIPOCYTE_DIFFERENTIATION_DN": "Genes down-regulated in primary adipocytes compared to preadipocytes.", "URS_ADIPOCYTE_DIFFERENTIATION_UP": "Genes up-regulated in primary adipocytes compared to preadipocytes.", "VALK_AML_CLUSTER_1": "Top 40 genes from cluster 1 of acute myeloid leukemia (AML) expression profile; 57% of the samples are FAB M1 subtype,  43% have 11q23 abnormalities, and 36% have up-regulated EVI1 [GeneID=2122] expression.", "UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN": "Genes up-regulated in HUVEC cells (primary endothelium) after stimulation with leukotriene LTD4 [PubChem=3908] or thrombin (F2) [GeneID=2147] for 1 h.", "VALK_AML_CLUSTER_10": "Top 40 genes from cluster 10 of acute myeloid leukemia (AML) expression profile; 41% of the samples are FAB M1 subtype, 45% have up-regulated EVI1 [GeneID=2122] expression; indicate poor survival.", "VALK_AML_CLUSTER_11": "Top 40 genes from cluster 11 of acute myeloid leukemia (AML) expression profile; 67% of the samples are FAB M4 or M5.", "VALK_AML_CLUSTER_13": "Top 40 genes from cluster 13 of acute myeloid leukemia (AML) expression profile; 91% of the samples are FAB M2 subtype, all bear the t(8;21) translocation producing the AML1-ETO fusion [GeneID=861;862]; indicate good survival.", "VALK_AML_CLUSTER_12": "Top 40 genes from cluster 12 of acute myeloid leukemia (AML) expression profile; 89% of the samples are FAB M3 subtype, 95% bear the t(15;17) translocation, all have the PML-RARA fusion [GeneID=5371;5914]; indicate good survival.", "VALK_AML_CLUSTER_16": "Top 40 genes from cluster 16 of acute myeloid leukemia (AML) expression profile; 81% of the samples are FAB M5 subtype, 45% have 11q23 abnormalities.", "VALK_AML_CLUSTER_15": "Top 40 genes from cluster 15 of acute myeloid leukemia (AML) expression profile; 88% of the samples are FAB M1 or M2 subtype, 63% have mutations in CEBPA [GeneID=1050].", "VALK_AML_CLUSTER_2": "Top 40 genes from cluster 2 of acute myeloid leukemia (AML) expression profile; 71% of the samples are FAB M4 or M5 subtypes, and 82% bear internal tundem duplications in FLT3 [GeneID=2322].", "VALK_AML_CLUSTER_3": "Top 40 genes from cluster 3 of acute myeloid leukemia (AML) expression profile; 84% of the samples are FAB M1 or M2 subtypes, 52% bear intern tandem duplication in FLT3 [GeneID=2322].", "VALK_AML_CLUSTER_5": "Top 40 genes from cluster 5 of acute myeloid leukemia (AML) expression profile; 96% of the samples are FAB M4 or M5 subtype.", "VALK_AML_CLUSTER_4": "Top 40 genes from cluster 4 of acute myeloid leukemia (AML) expression profile; 87% of the samples are FAB M1 subtype, 53% bear mutations in CEBPA [GeneID=1050].", "VALK_AML_CLUSTER_6": "Top 40 genes from cluster 6 of acute myeloid leukemia (AML) expression profile; all samples are FAB M1 or M2 subtypes and all samples have internal tundem duplication of FLT3 [GeneID=2322].", "VALK_AML_CLUSTER_7": "Top 40 genes from cluster 7 of acute myeloid leukemia (AML) expression profile; 61% of the samples are FAB M1 or M2 subtype.", "VALK_AML_CLUSTER_9": "Top 40 genes from cluster 9 of acute myeloid leukemia (AML) expression profile; 87% of the samples are FAB M4 or M5 subtype, all have inv(16) inversion producing the CBFB-MYH11 fusion [GeneID=865;4629]; indicate good survival.", "VALK_AML_CLUSTER_8": "Top 40 genes from cluster 8 of aculte myeloid leukemia (AML) expression profile; 69% of the samples are FAB M2 subtype.", "VALK_AML_WITH_11Q23_REARRANGED": "Genes that best predicted acute myeloid leukemia (AML) with the 11q23 rearrangements.", "VALK_AML_WITH_CEBPA": "Genes that best predicted acute myeloid leukemia (AML) with mutations in CEBPA [GeneID=1050].", "VALK_AML_WITH_FLT3_ITD": "Genes that best predicted acute myeloid leukemia (AML) with internal tandem duplications (IDT) in FLT3 [GeneID=2322].", "VALK_AML_WITH_EVI1": "Genes that best predicted acute myeloid leukemia (AML) with the up-regulated expression of EVI1 [GeneID=2122].", "VALK_AML_WITH_T_8_21_TRANSLOCATION": "Genes that best predicted acute myeloid leukemia (AML) with the t(8;21) translocation producing the AML1-ETO fusion [GeneID=861;862].", "VANDESLUIS_COMMD1_TARGETS_GROUP_2_UP": "Genes up-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout compared to normal 8.5 dpc and 9.5 dpc embryos.", "VANASSE_BCL2_TARGETS_DN": "Genes down-regulated in primary B lymphocytes engineered to overexpress BCL2 [GeneID=12043].", "VANASSE_BCL2_TARGETS_UP": "Genes up-regulated in primary B lymphocytes engineered to overexpress BCL2 [GeneID=12043].", "VANDESLUIS_COMMD1_TARGETS_GROUP_3_UP": "Genes up-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout compared to normal 9.5 dpc embryos.", "VANDESLUIS_COMMD1_TARGETS_GROUP_3_DN": "Genes down-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout compared to normal 9.5 dpc embryos.", "VANDESLUIS_COMMD1_TARGETS_GROUP_4_DN": "Genes down-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout and in normal 8.5 dpc embryos compared to normal 9.5 dpc embryos.", "VANDESLUIS_COMMD1_TARGETS_GROUP_4_UP": "Genes up-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout and in normal 8.5 dpc embryos compared to normal 9.5 dpc embryos.", "VANDESLUIS_NORMAL_EMBRYOS_UP": "Genes up-regulated in normal 9.5 days post coitus (dpc) embryos compared to normal 8.5 dpc and 9.5 dpc embryos.", "VANDESLUIS_NORMAL_EMBRYOS_DN": "Genes down-regulated in normal 9.5 days post coitus (dpc) embryos compared to normal 8.5 dpc and 9.5 dpc embryos.", "VANHARANTA_UTERINE_FIBROID_DN": "Genes down-regulated in uterine fibroids vs normal myometrium samples.", "VANHARANTA_UTERINE_FIBROID_UP": "Genes up-regulated in uterine fibroids vs normal myometrium samples.", "VANHARANTA_UTERINE_FIBROID_WITH_7Q_DELETION_DN": "Genes down-regulated in uterine fibroids with deletions in the 7q region vs those without the deletion.", "VANHARANTA_UTERINE_FIBROID_WITH_7Q_DELETION_UP": "Genes up-regulated in uterine fibroids with deletions in the 7q region vs those without the deletion.", "VANLOO_SP3_TARGETS_UP": "Genes up-regulated in E12.5 hearts from mice with SP3 [GeneID=6670] knockout compared to the wild type organ.", "VANLOO_SP3_TARGETS_DN": "Genes down-regulated in E12.5 hearts from mice with SP3 [GeneID=6670] knockout compared to the wild type organ.", "VANTVEER_BREAST_CANCER_BRCA1_DN": "Down-regulated genes from the optimal set of 100 markers discriminating ER(-) breast cancer tumors by  BRCA1 [GeneID=672] mutation status.", "VANTVEER_BREAST_CANCER_BRCA1_UP": "Up-regulated genes from the optimal set of 100 markers discriminating ER(-) breast cancer tumors by  BRCA1 [GeneID=672] mutation status.", "VANOEVELEN_MYOGENESIS_SIN3A_TARGETS": "Loci bound exclusively by SIN3A [GeneID=25942] in myotubules.", "VANTVEER_BREAST_CANCER_METASTASIS_DN": "Genes whose expression is significantly and negatively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years).", "VANTVEER_BREAST_CANCER_POOR_PROGNOSIS": "The optimal set of 70 prognostic markers predicting poor breast cancer clinical outcome (defined as developing metastases with 5 years).", "VANTVEER_BREAST_CANCER_METASTASIS_UP": "Genes whose expression is significantly and positively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years).", "VANTVEER_BREAST_CANCER_ESR1_DN": "Down-regulated genes from the optimal set of 550 markers discriminating breast cancer samples by ESR1 [GeneID=2099] expression: ER(+) vs ER(-) tumors.", "VANTVEER_BREAST_CANCER_ESR1_UP": "Up-regulated genes from the optimal set of 550 markers discriminating breast cancer samples by ESR1 [GeneID=2099] expression: ER(+) vs ER(-) tumors.", "VARELA_ZMPSTE24_TARGETS_DN": "Top genes down-regulated in liver tissue from mice with knockout of ZMPSTE24 [GeneID=10269].", "VARELA_ZMPSTE24_TARGETS_UP": "Top genes up-regulated in liver tissue from mice with knockout of ZMPSTE24 [GeneID=10269].", "VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_DN": "Down-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC).", "VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP": "Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC).", "VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN": "Angiogenic markers down-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus).", "VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP": "Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus).", "VERHAAK_AML_WITH_NPM1_MUTATED_UP": "Genes up-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [GeneID=4869].", "VERHAAK_GLIOBLASTOMA_CLASSICAL": "Genes correlated with classical type of glioblastoma multiforme tumors.", "VECCHI_GASTRIC_CANCER_EARLY_UP": "Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples.", "VERHAAK_AML_WITH_NPM1_MUTATED_DN": "Genes down-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [GeneID=4869].", "VERHAAK_GLIOBLASTOMA_MESENCHYMAL": "Genes correlated with mesenchymal type of glioblastoma multiforme tumors.", "VERHAAK_GLIOBLASTOMA_NEURAL": "Genes correlated with neural type of glioblastoma multiforme tumors.", "VECCHI_GASTRIC_CANCER_EARLY_DN": "Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples.", "VERNELL_RETINOBLASTOMA_PATHWAY_DN": "Cluster 2: genes down-regulated by RB1, CDNK2A [GeneID=1029;5925], and one of the E2Fs (E2F1, E2F2, or E2F3 [GeneID=1869;1870;1871]).", "VERNELL_RETINOBLASTOMA_PATHWAY_UP": "Cluster 1: genes up-regulated by RB1, CDNK2A [GeneID=1029;5925], and one of the E2Fs (E2F1, E2F2, or E2F3 [GeneID=1869;1870;1871]).", "VERNOCHET_ADIPOGENESIS": "Genes up-regulated during adipogenic differentiation of 3T3-L1 cells (preadipocyte) and down-regulated by troglitazone [PubChem=5591].", "VERRECCHIA_RESPONSE_TO_TGFB1_C1": "Cluster 1: ECM related genes up-regulated in dermal fibroblasts within 30 min after TGFB1 [GeneID=7040] addition, and which kept increasing with time.", "VERHAAK_GLIOBLASTOMA_PRONEURAL": "Genes correlated with proneural type of glioblastoma multiforme tumors.", "VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1": "ECM related genes up-regulated later than 30 min following addition of TGFB1 [GeneID=7040] in dermal fibroblasts.", "VERRECCHIA_RESPONSE_TO_TGFB1_C3": "Cluster 3: ECM related genes up-regulated in dermal fibroblasts within 30 min after TGFB1 [GeneID=7040] addition; returned rapidly to basal level after that.", "VERRECCHIA_RESPONSE_TO_TGFB1_C4": "Cluster 4: ECM related genes up-regulated in dermal fibroblasts later than 30 min after TGFB1 [GeneID=7040] addition; kept increasing with time.", "VERRECCHIA_RESPONSE_TO_TGFB1_C2": "Cluster 2: ECM related genes up-regulated in dermal fibroblasts within 30 min after TGFB1 [GeneID=7040] addition; reached a plateau after that.", "VERRECCHIA_EARLY_RESPONSE_TO_TGFB1": "ECM related genes up-regulated early (within 30 min) in dermal fibroblasts after addition of TGFB1 [GeneID=7040].", "VERRECCHIA_RESPONSE_TO_TGFB1_C5": "Cluster 5: ECM related genes up-regulated in dermal fibroblasts later than 30 min after TGFB1 [GeneID=7040] addition; decreased slowly after the peak at 120 min time point.", "VERRECCHIA_RESPONSE_TO_TGFB1_C6": "Cluster 6: ECM related genes up-regulated in dermal fibroblasts later than 30 min after TGFB1 [GeneID=7040] addition; slowly increased up to 120 min time point, then reached a plateau.", "VETTER_TARGETS_OF_PRKCA_AND_ETS1_DN": "Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PRKCA and ETS1 [GeneID=5578;2113] by RNAi.", "VICENT_METASTASIS_UP": "The metastasis gene signature: genes up-regulated during metastasis of NSCLC (non-small cell lung carcinoma) tumors to bone.", "VETTER_TARGETS_OF_PRKCA_AND_ETS1_UP": "Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PRKCA and ETS1 [GeneID=5578;2113] by RNAi.", "VILIMAS_NOTCH1_TARGETS_DN": "Genes down-regulated in bone marrow progenitors by constitutively active NOTCH1 [GeneID=4851].", "VISALA_AGING_LYMPHOCYTE_DN": "Genes down-regulated in peripheral lymphocytes from old individuals compared to those from young donors.", "VIETOR_IFRD1_TARGETS": "Genes down-regulated in c-JunER cells (mammary gland epithelum) by overexpression of IFRD1 [GeneID=3475] off an adenovirus vector.", "VILLANUEVA_LIVER_CANCER_KRT19_DN": "Genes under-expressed in KRT19-positive [GeneID=3880] hepatocellular carcinoma (HCC).", "VILIMAS_NOTCH1_TARGETS_UP": "Genes up-regulated in bone marrow progenitors by constitutively active NOTCH1 [GeneID=4851].", "VISALA_AGING_LYMPHOCYTE_UP": "Genes up-regulated in peripheral lymphocytes from old individuals compared to those from young donors.", "VISALA_RESPONSE_TO_HEAT_SHOCK_AND_AGING_DN": "Genes down-regulated after heat shock in peripheral lympocytes from old donors, compared to those from the young ones.", "WACKER_HYPOXIA_TARGETS_OF_VHL": "Genes down-regulated by VHL [GeneID=7428] and re-expressed under hypoxia conditions in renal carcinoma cells.", "VISALA_RESPONSE_TO_HEAT_SHOCK_AND_AGING_UP": "Genes up-regulated after heat shock in peripheral lympocytes from old donors, compared to those from the young ones.", "VILLANUEVA_LIVER_CANCER_KRT19_UP": "Genes over-expressed in KRT19-positive [GeneID=3880] hepatocellular carcinoma (HCC).", "WAESCH_ANAPHASE_PROMOTING_COMPLEX": "Subunits of the anaphase promoting complex (APC).", "WAGNER_APO2_SENSITIVITY": "Genes whose expression most significantly correlated with cancer cell line sensitivity to the proapoptotic ligand APO2 [GeneID=8797].", "WAGSCHAL_EHMT2_TARGETS_UP": "Genes up-regulated in placenta of mice with EHMT2 [GeneID=10919] knocked out.", "WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_36HR": "Genes with promoters bound by PPARG [GeneID=5468] at 36 h time point of adipocyte differentiation of 3T3-L1 cells (preadipocyte).", "WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR": "Genes with promoters bound by both PPARG and RXRA [GeneID=5468] [GeneID=6256] at 36 h time point of adipocyte differentiation of 3T3-L1 cells (preadipocyte).", "WALLACE_JAK2_TARGETS_UP": "Genes up-regulated more than 7-fold by expressing JAK2 [GeneID=3717] in the JAK2 null cell line.", "WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_WITH_H4K20ME1_MARK": "Genes with promoters bound by both PPARG and RXRA [GeneID=5468] [GeneID=6256] at 8 (but not 0) day time point of adipocyte differentiation of 3T3-L1 cells (preadipocyte) and that were newly modified by H4K20me1.", "WAKASUGI_HAVE_ZNF143_BINDING_SITES": "DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites.", "WALLACE_PROSTATE_CANCER_DN": "Genes down-regulated in prostate tumor vs normal tissue samples.", "WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D": "Genes with promoters bound by PPARG [GeneID=5468] at 8 day time point of adipocyte differentiation of 3T3-L1 cells (preadipocyte).", "WALLACE_PROSTATE_CANCER_RACE_DN": "Genes down-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients.", "WALLACE_PROSTATE_CANCER_UP": "Genes up-regulated in prostate tumor vs normal tissue samples.", "WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D": "Genes with promoters bound by both PPARG and RXRA [GeneID=5468] [GeneID=6256] at 8 day time point of adipocyte differentiation of 3T3-L1 cells (preadipocyte).", "WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN": "Genes down-regulated in mucinous ovarian carcinoma tumors of grades 1 and 2 compared to the normal ovarian survace epithelium tissue.", "WALLACE_PROSTATE_CANCER_RACE_UP": "Genes up-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients.", "WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP": "Genes up-regulated in mucinous ovarian carcinoma tumors of grades 1 and 2 compared to the normal ovarian survace epithelium tissue.", "WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN": "Genes down-regulated in mucinous ovarian carcinoma tumors of low malignant potential (LMP) compared to normal ovarian surface epithelium tissue.", "WANG_ADIPOGENIC_GENES_REPRESSED_BY_SIRT1": "Adipogenic genes (group 2) that are selectively repressed by  SIRT1 [GeneID=23411] in mature 3T3-L1 adipocytes.", "WANG_BARRETTS_ESOPHAGUS_DN": "Genes down-regulated in Barrett's esophagus compared to the normal tissue.", "WANG_BARRETTS_ESOPHAGUS_AND_ESOPHAGUS_CANCER_DN": "Genes down-regulated in esophageal adenocarcinoma (EAC) and Barret's esophagus (BE) relative to normal esophagi.", "WANG_BARRETTS_ESOPHAGUS_AND_ESOPHAGUS_CANCER_UP": "Genes up-regulated in esophageal adenocarcinoma (EAC) and Barret's esophagus (BE) relative to normal esophagi.", "WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP": "Genes up-regulated in mucinous ovarian carcinoma tumors of low malignant potential (LMP) compared to normal ovarian surface epithelium tissue.", "WANG_BARRETTS_ESOPHAGUS_UP": "Genes up-regulated in Barrett's esophagus compared to the normal tissue.", "WANG_CISPLATIN_RESPONSE_AND_XPC_DN": "Genes down-regulated in fibroblasts with defective XPC [GeneID=7508] in response to cisplatin [PubChem=2767].", "WANG_CLASSIC_ADIPOGENIC_TARGETS_OF_PPARG": "Classic adipogenic genes (group 1) that are induced by PPARG  [GeneID=5468] during adipogenesis in 3T3-L1 preadipocytes.", "WANG_CISPLATIN_RESPONSE_AND_XPC_UP": "Genes up-regulated in fibroblasts with defective XPC [GeneID=7508] in response to cisplatin [PubChem=2767].", "WANG_ESOPHAGUS_CANCER_PROGRESSION_UP": "Candidate progression biomarkers up-regulated in transition from non-tumor-risk associated to tumor-risk associated Barrett's esophagus and then to esophageal adenocarcinoma (EAC).", "WANG_CLIM2_TARGETS_DN": "Genes down-regulated in MCF7 cells (breast cancer) engineered to conditionally express a dominant negative form of CLIM2 [GeneID=8861] by a Tet Off system.", "WANG_HCP_PROSTATE_CANCER": "Genes with the high-CpG-density promoters (HCP) that were up-regulated in 1542-CP3TX cells (prostate cancer) compared to 1542-NPTX (normal prostate).", "WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_DN": "Down-regulated genes in myeloid progenitors immortalized by HOXA9 [GeneID=3205] vs those immortalized by HOXA9 and MEIS1 [GeneID=4211].", "WANG_CLIM2_TARGETS_UP": "Genes up-regulated in MCF7 cells (breast cancer) engineered to conditionally express a dominant negative form of CLIM2 [GeneID=8861] by a Tet Off system.", "WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN": "Down-regulated genes specific to esophageal adenocarcinoma (EAC) relative to normal tissue.", "WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP": "Up-regulated genes specific to esophageal adenocarcinoma (EAC) relative to normal tissue.", "WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP": "Up-regulated genes in myeloid progenitors immortalized by HOXA9 [GeneID=3205] vs those immortalized by HOXA9 and MEIS1 [GeneID=4211].", "WANG_LSD1_TARGETS_UP": "Genes up-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary.", "WANG_LSD1_TARGETS_DN": "Genes down-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary.", "WANG_METASTASIS_OF_BREAST_CANCER_ESR1_DN": "Genes whose expression in primary ER(+) [GeneID=2099] breast cancer tumors negatively correlates with developing distant metastases.", "WANG_LMO4_TARGETS_DN": "Genes down-regulated in MCF7 cells (breast cancer) engineered to conditionally express LMO4 [GeneID=8543] by a Tet Off system.", "WANG_METASTASIS_OF_BREAST_CANCER": "Genes whose expression in primary ER(-) [GeneID=2099] breast cancer tumors negatively correlates with developing distant metastases.", "WANG_METASTASIS_OF_BREAST_CANCER_ESR1_UP": "Genes whose expression in primary ER(+) [GeneID=2099] breast cancer tumors positively correlates with developing distant metastases.", "WANG_METHYLATED_IN_BREAST_CANCER": "Genes up-regulated in MDA468 cells (breast cancer) vs DU99 cells (normal breast) after treatment with azacytidine [PubChem=9444].", "WANG_LMO4_TARGETS_UP": "Genes up-regulated in MCF7 cells (breast cancer) engineered to conditionally express LMO4 [GeneID=8543] by a Tet Off system.", "WANG_NEOPLASTIC_TRANSFORMATION_BY_CCND1_MYC": "Selected genes changed in NMuMG cells (mammary epithelium) transformed by overexpression of CCND1 [GeneID=595] vs those transformed by overexpression of CCND1 and MYC [GeneID=4609].", "WANG_MLL_TARGETS": "Genes requiring MLL [GeneID=4297] for H3K4me3 and expression in MEF cells (embryonic fibroblast).", "WANG_RECURRENT_LIVER_CANCER_DN": "Genes down-regulated in samples from patients with recurrent hepatocellular carcinoma (HCC).", "WANG_NFKB_TARGETS": "Representative genes up-regulated in C2C12 cells (myoblast) lacking NFkB activity due to expression of a super repressor form of NFKBIA [GeneID=4792].", "WANG_RECURRENT_LIVER_CANCER_UP": "Genes up-regulated in samples from patients with recurrent hepatocellular carcinoma (HCC).", "WANG_PROSTATE_CANCER_ANDROGEN_INDEPENDENT": "Genes changed in prostate cancer: androgen independent vs androgen dependent samples.", "WANG_RESPONSE_TO_FORSKOLIN_DN": "Genes down-regulated in LNCaP cells (prostate cancer) treated with forskolin [PubChem=47936], an activator of PKA pathway.", "WANG_RESPONSE_TO_BEXAROTENE_DN": "Genes down-regulated in the mouse lung cancer model and which reverted to normal levels upon treatment with bexarotene [PubChem=82146].", "WANG_RESPONSE_TO_ANDROGEN_UP": "Genes up-regulated in LNCaP cells (prostate cancer) treated with synthetic androgen R1881 [PubChem=13766].", "WANG_RESPONSE_TO_BEXAROTENE_UP": "Genes up-regulated in the mouse lung cancer model and which reverted to normal levels upon treatment with bexarotene [PubChem=82146].", "WANG_RESPONSE_TO_FORSKOLIN_UP": "Genes up-regulated in LNCaP cells (prostate cancer) treated with forskolin [PubChem=47936], an activator of PKA pathway.", "WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN": "Genes down-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChem=176158], an inhibitor of GSK3B [GeneID=2932].", "WANG_TARGETS_OF_MLL_CBP_FUSION_DN": "Top 50 genes down-regulated in granulocyte/macrophage progenitors (GMP) upon expression of MLL-CBP fusion [GeneID=4297;1387].", "WANG_TARGETS_OF_MLL_CBP_FUSION_UP": "Top 50 genes up-regulated in granulocyte/macrophage progenitors (GMP) upon expression of MLL-CBP fusion [GeneID=4297;1387].", "WANG_SMARCE1_TARGETS_UP": "Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector.", "WANG_TNF_TARGETS": "Representative genes up-regulated in MEF cells (embryonic fibroblast) in response to TNF [GeneID=7124].", "WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP": "Genes up-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChem=176158], an inhibitor of GSK3B [GeneID=2932].", "WANG_SMARCE1_TARGETS_DN": "Genes down-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector.", "WANG_THOC1_TARGETS_DN": "Genes down-regulated in testis tissue expressing hypomorphic allele of THOC1 [GeneID=9984].", "WANG_TUMOR_INVASIVENESS_DN": "Down-regulated genes in the subpopulation of invasive PyMT cells (breast cancer) compared to the general population of PyMT cells.", "WARTERS_IR_RESPONSE_5GY": "Genes up-regulated in the human skin cells at 4 h after exprosure to 5 Gy dose of ionizing radiation.", "WANG_THOC1_TARGETS_UP": "Genes up-regulated in testis tissue expressing hypomorphic allele of THOC1 [GeneID=9984].", "WARTERS_RESPONSE_TO_IR_SKIN": "Genes displaying an ionizing radiation response in the human skin cell samples.", "WATANABE_COLON_CANCER_MSI_VS_MSS_DN": "Down-regulated genes discriminating between MSI (microsatellite instability) and MSS (microsatellite stability) colon cancers.", "WATANABE_COLON_CANCER_MSI_VS_MSS_UP": "Up-regulated genes discriminating between MSI (microsatellite instability) and MSS (microsatellite stability) colon cancers.", "WANG_TUMOR_INVASIVENESS_UP": "Up-regulated genes in the subpopulation of invasive PyMT cells (breast cancer) compared to the general population of PyMT cells.", "WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_DN": "Genes down-regulated in rectal cancer patients resistant to radiotherapy (non-responders) relative to the sensitive ones (responders).", "WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_DN": "Genes down-regulated in non-neoplastic rectal mucosa samples from patients having cancer associated with ulcerative collitis, compared to those who did not have the cancer.", "WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP": "Genes up-regulated in rectal cancer patients resistant to radiotherapy (non-responders) relative to the sensitive ones (responders).", "WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_UP": "Genes up-regulated in non-neoplastic rectal mucosa samples from patients having cancer associated with ulcerative collitis, compared to those who did not have the cancer.", "WEBER_METHYLATED_HCP_IN_FIBROBLAST_UP": "Methylated germline-specific genes with high-CpG-density promoters (HCP) in primary fibroblasts.", "WEBER_METHYLATED_HCP_IN_FIBROBLAST_DN": "Unmethylated germline-specific genes with high-CpG-density promoters (HCP) in primary fibroblasts.", "WEBER_METHYLATED_HCP_IN_SPERM_UP": "Methylated germline-specific genes with high-CpG-density promoters (HCP) in sperm.", "WEBER_METHYLATED_HCP_IN_SPERM_DN": "Unmethylated germline-specific genes with high-CpG-density promoters (HCP) in sperm.", "WEBER_METHYLATED_ICP_IN_SPERM_UP": "Methylated germline-specific genes with intermediate-CpG-density promoters (ICP) in sperm.", "WEBER_METHYLATED_ICP_IN_SPERM_DN": "Unmethylated germline-specific genes with intermediate-CpG-density promoters (ICP) in sperm.", "WEBER_METHYLATED_IN_COLON_CANCER": "Genes identified as hypermethylated in SW48 cells (colon cancer).", "WEBER_METHYLATED_ICP_IN_FIBROBLAST": "Germline-specific genes with intermediate-CpG-density promoters (ICP) that are methylated in primary fibroblasts.", "WEBER_METHYLATED_LCP_IN_FIBROBLAST_UP": "Methylated germline-specific genes with low-CpG-density promoters (LCP) in primary fibroblasts.", "WEBER_METHYLATED_LCP_IN_FIBROBLAST_DN": "Unmethylated germline-specific genes with low-CpG-density promoters (LCP) in primary fibroblasts.", "WEBER_METHYLATED_LCP_IN_SPERM_DN": "Unmethylated germline-specific genes with low-CpG-density promoters (LCP) in sperm.", "WEBER_METHYLATED_LCP_IN_SPERM_UP": "Methylated germline-specific genes with low-CpG-density promoters (LCP) in sperm.", "WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2": "Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE and H2O2 [PubChem=5283344;784].", "WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH": "Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE and tBH [PubChem=5283344;6410].", "WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2": "Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to tert-butyl hydroperoxide (tBH) and H2O2 [PubChem=6410;784].", "WEIGEL_OXIDATIVE_STRESS_RESPONSE": "Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE, tBH and H2O2 [PubChem=5283344;6410;784].", "WEINMANN_ADAPTATION_TO_HYPOXIA_UP": "Genes most up-regulated in hypoxia tolerant NCI H460 cells (lung cancer).", "WELCH_GATA1_TARGETS": "Genes up-regulated after GATA1 [GeneID=2623] activation in G1E-ER4 cells (erythroid precursors engineered to express GATA1 upon addition of estradiol [PubChem=5757]).", "WEI_MIR34A_TARGETS": "Potential direct target genes for MIR34A [GeneID=407040] microRNA in IMR32 cells (neuroblastoma).", "WEINMANN_ADAPTATION_TO_HYPOXIA_DN": "Genes most down-regulated in hypoxia tolerant NCI H460 cells (lung cancer).", "WELCSH_BRCA1_TARGETS_DN": "Down-regulated by induction of exogenous BRCA1 in EcR-293 cells", "WENG_POR_DOSAGE": "Genes up-regulated in liver from mice with liver specific knockout of POR [GeneID=5447] vs mice with reduced expression of POR in all tissues.", "WENG_POR_TARGETS_GLOBAL_DN": "Genes down-regulated in liver from transgenic mice with reduced expression of POR [GeneID=5447] in all tissues.", "WENDT_COHESIN_TARGETS_UP": "Cohesin targets identified by ChIP-chip which were up-regulated after knockdown of CTCF and RAD21 [GeneID=10664;5885] by RNAi.", "WEI_MYCN_TARGETS_WITH_E_BOX": "Genes whose promoters contain E-box motifs and whose expression changed in MYCN-3 cells (neuroblastoma) upon induction of MYCN [GeneID=4613].", "WENG_POR_TARGETS_GLOBAL_UP": "Genes up-regulated in liver from transgenic mice with reduced expression of POR [GeneID=5447] in all tissues.", "WELCSH_BRCA1_TARGETS_UP": "Up-regulated by induction of exogenous BRCA1 in EcR-293 cells", "WENG_POR_TARGETS_LIVER_DN": "Genes down-regulated in liver from mice with liver specific knockout of POR [GeneID=5447].", "WESTON_VEGFA_TARGETS": "Genes up-regulated in MMEC cells (myometrial endothelium) by VEGFA [GeneID=7422] stimulation.", "WENG_POR_TARGETS_LIVER_UP": "Genes up-regulated in liver from mice with liver specific knockout of POR [GeneID=5447].", "WESTON_VEGFA_TARGETS_12HR": "Genes up-regulated in MMEC cells (myometrial endothelium) at 12 h after VEGFA [GeneID=7422] stimulation.", "WESTON_VEGFA_TARGETS_6HR": "Genes up-regulated in MMEC cells (myometrial endothelium) at 6 h after VEGFA [GeneID=7422] stimulation.", "WESTON_VEGFA_TARGETS_3HR": "Genes up-regulated in MMEC cells (myometrial endothelium) at 3 h after VEGFA [GeneID=7422] stimulation.", "WEST_ADRENOCORTICAL_CARCINOMA_VS_ADENOMA_UP": "Up-regulated genes in pediatric adrenocortical carcinoma (ACC) compared to the adenoma (ACA) tumors.", "WEST_ADRENOCORTICAL_CARCINOMA_VS_ADENOMA_DN": "Down-regulated genes in pediatric adrenocortical carcinoma (ACC) compared to the adenoma (ACA) tumors.", "WEST_ADRENOCORTICAL_TUMOR_MARKERS_UP": "Top up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue.", "WEST_ADRENOCORTICAL_TUMOR_MARKERS_DN": "Top down-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue.", "WHITEFORD_PEDIATRIC_CANCER_MARKERS": "Differentially expressed genes in a panel of xenografts representing 8 common pediatric tumors compared to the normal tissues.", "WHITESIDE_CISPLATIN_RESISTANCE_DN": "Genes down-regulated in NCI-H2170 cells (lung cancer) upon induction of resistance to cisplatin [PubChem=2767].", "WEST_ADRENOCORTICAL_TUMOR_DN": "Down-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue.", "WHITE_NEUROBLASTOMA_WITH_1P36.3_DELETION": "Genes within the smallest region of consistend deletion (SRD) within 1p36.3 area across a large collection of neuroblastoma cell lines and biopsy samples.", "WHITEHURST_PACLITAXEL_SENSITIVITY": "Genes that reduced viability of NCI-H1155 cells (non-small-cell lung cancer, NSCLC) in the presence of otherwise sublethal concentrations of paclitaxel [PubChem=4666], based on RNAi synthetic lethal screen.", "WEST_ADRENOCORTICAL_TUMOR_UP": "Up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue.", "WHITESIDE_CISPLATIN_RESISTANCE_UP": "Genes up-regulated in NCI-H2170 cells (lung cancer) upon induction of resistance to cisplatin [PubChem=2767].", "WHITFIELD_CELL_CYCLE_G1_S": "Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G1/S phase of cell cycle.", "WHITFIELD_CELL_CYCLE_G2": "Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G2 phase of cell cycle.", "WHITFIELD_CELL_CYCLE_G2_M": "Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G2/M phase of cell cycle.", "WHITFIELD_CELL_CYCLE_LITERATURE": "A list of known cell cycle regulated genes that was compiled from the literature by the authors.", "WIEMANN_TELOMERE_SHORTENING_AND_CHRONIC_LIVER_DAMAGE_UP": "Genes up-regulated by telomere shortening due to the knockout of TERC [GeneID=7012] in the presence of chronic liver damage.", "WIEMANN_TELOMERE_SHORTENING_AND_CHRONIC_LIVER_DAMAGE_DN": "Genes down-regulated by telomere shortening due to the knockout of TERC [GeneID=7012] in the presence of chronic liver damage.", "WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2": "Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of both BMI1 and PCGF2 [GeneID=648] [GeneID=7703] by RNAi.", "WHITFIELD_CELL_CYCLE_M_G1": "Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the M/G1 phase of cell cycle.", "WIELAND_UP_BY_HBV_INFECTION": "Genes induced in the liver during hepatitis B (HBV) viral clearance in chimpanzees.", "WHITFIELD_CELL_CYCLE_S": "Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the S phase of cell cycle.", "WIERENGA_PML_INTERACTOME": "Proteins identified in complex with PML [GeneID=5371] in K562 cells (lymphoblast).", "WIERENGA_STAT5A_TARGETS_DN": "Genes down-regulated in CD34+ [GeneID=947] cells by intermediate activity levels of STAT5A [GeneID=6776]; predominant long-term growth and self-renewal phenotype.", "WIERENGA_STAT5A_TARGETS_GROUP1": "Genes up-regulated to their maximal levels in CD34+ [GeneID=947] cells by intermediate activity levels of STAT5A [GeneID=6776]; predominant long-term growth and self-renewal phenotype.", "WIERENGA_STAT5A_TARGETS_GROUP2": "Genes up-regulated in a linear fashion in CD34+ [GeneID=947] cells upon increasing activity levels of STAT5A [GeneID=6776]; predominant long-term growth and self-renewal phenotype.", "WIKMAN_ASBESTOS_LUNG_CANCER_UP": "Genes positively correlated with the asbestos exposure of lung cancer patients.", "WIKMAN_ASBESTOS_LUNG_CANCER_DN": "Genes negatively correlated with the asbestos exposure of lung cancer patients.", "WIERENGA_STAT5A_TARGETS_UP": "Genes up-regulated in CD34+ [GeneID=947] cells by intermediate activity levels of STAT5A [GeneID=6776]; predominant long-term growth and self-renewal phenotype.", "WILCOX_RESPONSE_TO_PROGESTERONE_DN": "Genes down-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days.", "WILLIAMS_ESR1_TARGETS_DN": "The 'ER-alpha profile': genes down-regulated in T47D cells (breast cancer, ESR2 [GeneID=2100] Tet-Off) upon activation of ESR1 [GeneID=2099] by estradiol (E2) [PubChem=5757].", "WILCOX_RESPONSE_TO_PROGESTERONE_UP": "Genes up-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days.", "WILENSKY_RESPONSE_TO_DARAPLADIB": "Atherosclerotic process genes whose coronary expression changed after darapladib [PubChem=9939609] treatment.", "WILLERT_WNT_SIGNALING": "Genes up-regulated in NCCIT cell line (embryonic teratocarcinoma) after stimulation with WNT3A [GeneID=89780].", "WILSON_PROTEASES_AT_TUMOR_BONE_INTERFACE_DN": "Protease genes down-regulated at tumor-bone interface compared to the tumor alone area.", "WILLIAMS_ESR2_TARGETS_DN": "Genes uniquely down-regulated in T47D cells (breast cancer) by induction of ESR2 [GeneID=2100] expression in the Tet-Off system.", "WILLIAMS_ESR2_TARGETS_UP": "Genes uniquely up-regulated in T47D cells (breast cancer) by induction of ESR2 [GeneID=2100] expression in the Tet-Off system.", "WILSON_PROTEASES_AT_TUMOR_BONE_INTERFACE_UP": "Protease genes up-regulated at tumor-bone interface compared to the tumor alone area.", "WILLIAMS_ESR1_TARGETS_UP": "The 'ER-alpha profile': genes up-regulated in T47D cells (breast cancer, ESR2 [GeneID=2100] Tet-Off) upon activation of ESR1 [GeneID=2099] by estradiol (E2) [PubChem=5757].", "WINTER_HYPOXIA_DN": "Genes down-regulated in head and neck tumor samples which clustered around known hypoxia genes.", "WINNEPENNINCKX_MELANOMA_METASTASIS_DN": "Genes from the 254-gene classifier which were down-regulated in melanoma patients with a reported distant metastasis within 4 years.", "WINTER_HYPOXIA_UP": "Genes up-regulated in head and neck tumor samples which clustered around known hypoxia genes.", "WINNEPENNINCKX_MELANOMA_METASTASIS_UP": "Genes from the 254-gene classifier which were up-regulated in melanoma patients with a reported distant metastasis within 4 years.", "WINTER_HYPOXIA_METAGENE": "Genes regulated by hypoxia, based on literature searches.", "WINZEN_DEGRADED_VIA_KHSRP": "Transcripts (mRNA molecules) rapidly degraded upon interaction with KHSRP [GeneID=8570].", "WONG_ENDMETRIUM_CANCER_DN": "Genes down-regulated in cancer endometrium samples compared to the normal endometrium.", "WONG_ENDMETRIUM_CANCER_UP": "Genes up-regulated in cancer endometrium samples compared to the normal endometrium.", "WONG_ENDOMETRIAL_CANCER_LATE": "Genes down-regulated in late stage (stage 3) endometrial cancers compared to the earlier stages (stage 1 and 2).", "WONG_EMBRYONIC_STEM_CELL_CORE": "The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module.", "WONG_ADULT_TISSUE_STEM_MODULE": "The 'adult tissue stem' module: genes coordinately up-regulated in a compendium of adult tissue stem cells.", "WOOD_EBV_EBNA1_TARGETS_DN": "Genes down-regulated in the Ad/AH cells (adenocarcinoma) engineered to stably express the Epstein-Barr virus (EBV) gene EBNA1.", "WONG_PROTEASOME_GENE_MODULE": "Genes that comprise the proteasome gene module", "WONG_MITOCHONDRIA_GENE_MODULE": "Genes that comprise the mitochondria gene module", "WOOD_EBV_EBNA1_TARGETS_UP": "Genes up-regulated in the Ad/AH cells (adenocarcinoma) engineered to stably express the Epstein-Barr virus (EBV) gene EBNA1.", "WOO_LIVER_CANCER_RECURRENCE_DN": "Genes negatively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC).", "WOO_LIVER_CANCER_RECURRENCE_UP": "Genes positively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC).", "WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_DN": "Selected genes with immunologic function which were reciprocally changed in evasion and tolerogenic tumor models.", "WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_UP": "Selected genes with immunologic function which were reciprocally changed in evasion and tolerogenic tumor models.", "WORSCHECH_TUMOR_REJECTION_DN": "Down-regulated genes defining rejection of mammary carcinoma (MMC) tumors.", "WORSCHECH_TUMOR_REJECTION_UP": "Up-regulated genes defining rejection of mammary carcinoma (MMC) tumors.", "WOTTON_RUNX_TARGETS_UP": "Common target genes up-regulated by all three Runx family members (RUNX1, RUNX2, and RUNX3 [GeneID=861;860;864]) in MEF cells (embryonic fibroblasts).", "WOTTON_RUNX_TARGETS_DN": "Common target genes down-regulated by all three Runx family members (RUNX1, RUNX2, and RUNX3 [GeneID=861;860;864]) in MEF cells (embryonic fibroblasts).", "WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_DN": "Genes down-regulated in gastric mucosal tissue of mice on 2% cholesterol [PubChem=5997] diet and infected with H. pylori vs those infected with H. pylori while on 0% cholesterol diet.", "WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UP": "Genes up-regulated in gastric mucosal tissue of mice on 2% cholesterol [PubChem=5997] diet and infected with H. pylori vs those infected with H. pylori while on 0% cholesterol diet.", "WU_ALZHEIMER_DISEASE_UP": "Genes up-regulated in brain endothelial cells from patients with Alzheimer disease.", "WU_ALZHEIMER_DISEASE_DN": "Genes down-regulated in brain endothelial cells from patients with Alzheimer disease.", "WU_APOPTOSIS_BY_CDKN1A_NOT_VIA_TP53": "Genes downstream of CDKN1A [GeneID=1026] in a TP53 [GeneID=7157] independent pathway in 2774qw1 cells (ovarian cancer).", "WU_APOPTOSIS_BY_CDKN1A_VIA_TP53": "Genes downstream of both CDKN1A and TP53 [GeneID=1026;7157] in 2774qw1 cells (ovarian cancer).", "WU_HBX_TARGETS_1_DN": "Genes down-regulated by expression of HBV X protein (HBVgp3) [GeneID=944566] in SK-Hep-1 cells (hepatocellular carcinoma).", "WU_HBX_TARGETS_1_UP": "Genes up-regulated by expression of HBV X protein (HBVgp3) [GeneID=944566] in SK-Hep-1 cells (hepatocellular carcinoma).", "WU_HBX_TARGETS_2_DN": "Genes down-regulated by expression of HBV X protein (HBVgp3) [GeneID=944566] in primary hepatocytes.", "WU_CELL_MIGRATION": "Genes associated with migration rate of 40 human bladder cancer cells.", "WU_HBX_TARGETS_2_UP": "Genes up-regulated by expression of HBV X protein (HBVgp3) [GeneID=944566] in primary hepatocytes.", "WU_HBX_TARGETS_3_DN": "Genes down-regulated by expression of HBV X protein (HBVgp3) [GeneID=944566] both in SK-Hep-1 cells (hepatocellular carcinoma) and normal primary hepatocytes.", "WU_HBX_TARGETS_3_UP": "Genes up-regulated by expression of HBV X protein (HBVgp3) [GeneID=944566] both in SK-Hep-1 cells (hepatocellular carcinoma) and normal primary hepatocytes.", "WU_SILENCED_BY_METHYLATION_IN_BLADDER_CANCER": "Genes silenced by DNA methylation in bladder cancer cell lines.", "XIE_LT_HSC_S1PR3_OE_UP": "Genes upregulated in long-term hematopoietic stem cells (CD34+,CD38_,CD45RA_,CD90+,CD49f+) upon overexpression of Sphingosine-1-Phosphate Receptor 3 (S1PR3)", "XU_AKT1_TARGETS_48HR": "Genes up-regulated in DU-145 cells (prostate cancer) expressing a dominant negative form of AKT1 [GeneID=207] upon sham-treatment for 48 h (as a control for the HGF [GeneID=3082] experiments).", "XIE_ST_HSC_S1PR3_OE_DN": "Genes downregulated in short-term hematopoietic stem cells (CD34+,CD38_,CD45RA_,CD90_,CD49f_) upon overexpression of Sphingosine-1-Phosphate Receptor 3 (S1PR3)", "XIE_ST_HSC_S1PR3_OE_UP": "Genes upregulated in short-term hematopoietic stem cells (CD34+,CD38_,CD45RA_,CD90_,CD49f_) upon overexpression of Sphingosine-1-Phosphate Receptor 3 (S1PR3)", "XU_CREBBP_TARGETS_UP": "Genes up-regulated in pro-B lymphocytes after knockout of CREBBP [GeneID=1387].", "XU_AKT1_TARGETS_6HR": "Genes up-regulated in DU-145 cells (prostate cancer) expressing a dominant negative form of AKT1 [GeneID=207] upon sham-treatment for 6 h (as a control for the HGF [GeneID=3082] experiments).", "XU_CREBBP_TARGETS_DN": "Genes down-regulated in pro-B lymphocytes after knockout of CREBBP [GeneID=1387].", "XU_GH1_AUTOCRINE_TARGETS_DN": "Genes down-regulated in MFCF-7 cells (breast cancer) upon stable autocrine expression of HG1 [GeneID=2688].", "XU_GH1_EXOGENOUS_TARGETS_DN": "Genes down-regulated in MFCF-7 cells (breast cancer) by exogenous HG1 [GeneID=2688].", "XU_GH1_AUTOCRINE_TARGETS_UP": "Genes up-regulated in MFCF-7 cells (breast cancer) upon stable autocrine expression of HG1 [GeneID=2688].", "XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_DN": "Genes down-regulated in DU-145 cells (prostate cancer) in the absence and presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 48 h.", "XU_GH1_EXOGENOUS_TARGETS_UP": "Genes up-regulated in MFCF-7 cells (breast cancer) by exogenous HG1 [GeneID=2688].", "XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_UP": "Genes up-regulated in DU-145 cells (prostate cancer) in the absence and presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 48 h.", "XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_UP": "Genes up-regulated in DU-145 cells (prostate cancer) in the absence but not in the presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 48 h.", "XU_HGF_SIGNALING_NOT_VIA_AKT1_6HR": "Genes changed similarly in DU-145 cells (prostate cancer) in the absence and presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 6 h.", "XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_DN": "Genes down-regulated in DU-145 cells (prostate cancer) in the absence but not in the presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 48 h.", "XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR": "Genes changed in DU-145 cells (prostate cancer) in the absence but not presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 6 h.", "XU_HGF_TARGETS_REPRESSED_BY_AKT1_UP": "Genes up-regulated in DU-145 cells (prostate cancer) in the presence but not in the absence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 48 h.", "XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN": "Genes down-regulated in DU-145 cells (prostate cancer) in the presence but not in the absence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 48 h.", "XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_DN": "Genes down-regulated synergistically in NB4 cells (acute promyelocytic leukemia, APL) by tretinoin and NSC682994 [PubChem=444795;388304].", "XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_UP": "Genes up-regulated synergistically in NB4 cells (acute promyelocytic leukemia, APL) by tretinoin and NSC682994 [PubChem=444795;388304].", "XU_RESPONSE_TO_TRETINOIN_DN": "Genes down-regulated in NB4 cells (acute promyelocytic leukemia, APL) by tretinoin [PubChem=444795] alone.", "XU_RESPONSE_TO_TRETINOIN_UP": "Genes up-regulated in NB4 cells (acute promyelocytic leukemia, APL) by tretinoin [PubChem=444795] alone.", "YAGI_AML_RELAPSE_PROGNOSIS": "Genes associated with clinical prognosis of pediatric AML (acute myeloid leukemia): good prognosis=no relapse > 3 years; poor prognosis=relapse < 1 year or no response to therapy.", "YAGI_AML_FAB_MARKERS": "Genes specifically expressed in FAB subtypes M2, M4, M5 and M7 of pediatric AML (acute myeloid leukemia).", "YAGI_AML_SURVIVAL": "Genes differentially expressed in pediatric AML (acute myeloid leukemia) samples from patients with good survival (>3 years without relapse) compared to those with poor survival (relapsed within one year after treatment).", "YAGUE_PRETUMOR_DRUG_RESISTANCE_UP": "Up-regulated genes common to all pretumorigenic cells with acquired drug resistance.", "YAGUE_PRETUMOR_DRUG_RESISTANCE_DN": "Down-regulated genes common to all pretumorigenic cells with acquired drug resistance.", "YAGI_AML_WITH_T_9_11_TRANSLOCATION": "Genes specifically expressed in samples from patients with pediatric acute myeloid leukemia (AML) bearing t(9;11) translocation.", "YAGI_AML_WITH_INV_16_TRANSLOCATION": "Genes specifically expressed in samples from patients with pediatric acute myeloid leukemia (AML) bearing inv(16) translocation.", "YAMANAKA_GLIOBLASTOMA_SURVIVAL_DN": "Genes whose expression most strongly and consistently associated with the short term survival of patients with high grade glioma tumors.", "YAGI_AML_WITH_11Q23_REARRANGED": "Genes specifically expressed in samples from patients with pediatric acute myeloid leukemia (AML) bearing 11q23 rearrangements.", "YAGI_AML_WITH_T_8_21_TRANSLOCATION": "Genes specifically expressed in samples from patients with pediatric AML (acute myeloid leukemia ) bearing t(8;21) translocation.", "YAMANAKA_GLIOBLASTOMA_SURVIVAL_UP": "Genes whose expression most strongly and consistently associated with the long term survival of patients with high grade glioma tumors.", "YAMASHITA_LIVER_CANCER_STEM_CELL_DN": "Genes down-regulated in hepatocellular carcinoma (HCC) cells with hepatic stem cell properties.", "YAMASHITA_LIVER_CANCER_STEM_CELL_UP": "Genes up-regulated in hepatocellular carcinoma (HCC) cells with hepatic stem cell properties.", "YAMASHITA_SILENCED_BY_METHYLATION": "Genes silenced by DNA methylation in prostate cancer cell lines.", "YAMASHITA_METHYLATED_IN_PROSTATE_CANCER": "Genes up-regulated in prostate cancer cell lines after treatment with 5-aza-2'-deoxycytidine (decitabine) [PubChem=451668].", "YANAGISAWA_LUNG_CANCER_RECURRENCE": "Genes defining a 25-signal proteomic signature associated with a high risk of cancer recurrence and poor survival of NSCLC (non-small cell lung cancer) patients.", "YAMASHITA_LIVER_CANCER_WITH_EPCAM_UP": "Up-regulated genes distinguishing hepatocellular carcinoma (HCC) samples positive for EPCAM [GeneID=4072] from the negative ones.", "YANAGIHARA_ESX1_TARGETS": "Genes down-regulated in U2-OS Tet-On cells (osteosarcoma) after induction of ESX1 [GeneID=80712] expression.", "YAMAZAKI_TCEB3_TARGETS_UP": "Genes up-regulated in embryonic stem cells from TCEB3 [GeneID=6924] knockout mice.", "YANG_BCL3_TARGETS_DN": "Genes down-regulated in neonatal cardiac myocytes upon knockdown of BCL3 [GeneID=602] by RNAi.", "YAMAZAKI_TCEB3_TARGETS_DN": "Genes down-regulated in embryonic stem cells from TCEB3 [GeneID=6924] knockout mice.", "YAMASHITA_LIVER_CANCER_WITH_EPCAM_DN": "Down-regulated genes distinguishing hepatocellular carcinoma (HCC) samples positive for EPCAM [GeneID=4072] from the negative ones.", "YANG_BCL3_TARGETS_UP": "Genes up-regulated in neonatal cardiac myocytes upon knockdown of BCL3 [GeneID=602] by RNAi.", "YANG_BREAST_CANCER_ESR1_BULK_UP": "Genes up-regulated in bulk samples from early primary breast tumors expressing ESR1 [GeneID=2099] vs the ESR1 negative samples.", "YANG_BREAST_CANCER_ESR1_BULK_DN": "Genes down-regulated in bulk samples from early primary breast tumors expressing ESR1 [GeneID=2099] vs the ESR1 negative samples.", "YANG_BREAST_CANCER_ESR1_LASER_DN": "Genes down-regulated in laser microdissected (LCM) samples of early primary breast tumors expressing ESR1 [GeneID=2099] vs the ESR1 negative ones.", "YANG_BREAST_CANCER_ESR1_DN": "Genes down-regulated in early primary breast tumors expressing ESR1 [GeneID=2099] vs the ESR1 negative ones.", "YANG_BREAST_CANCER_ESR1_LASER_UP": "Genes up-regulated in laser microdissected (LCM) samples of early primary breast tumors expressing ESR1 [GeneID=2099] vs the ESR1 negative ones.", "YANG_BREAST_CANCER_ESR1_UP": "Genes up-regulated in early primary breast tumors expressing ESR1 [GeneID=2099] vs the ESR1 negative ones.", "YAN_ESCAPE_FROM_ANOIKIS": "Genes up-regulated in IEC-18 cells (intestinal epithelial cells) which avoided anoikis (a form of apoptosis) after detachment.", "YAO_HOXA10_TARGETS_VIA_PROGESTERONE_DN": "Genes down-regulated in the uteri of ovariectomized mice 6 h after progesterone [PubChem=5994] injection: HOXA10 [GeneID=3206] knockout vs wild type animals.", "YAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP": "Genes up-regulated in the uteri of ovariectomized mice 6 h after progesterone [PubChem=5994] injection: HOXA10 [GeneID=3206] knockout vs wild type animals.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_0": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 0.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 10.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 1.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_12": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 12.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_11": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 11.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_15": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 15.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 14.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 13.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_16": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 16.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 17.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 2.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_3": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 3.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 5.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_4": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 4.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 6.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_7": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 7.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_8": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 8.", "YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9": "Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 9.", "YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN": "Genes down-regulated in mouse stroma of pancreatic adenocarcinoma zenografts after treatment with HhAntag, a hedgehog (Hh) pathway inhibitor.", "YEMELYANOV_GR_TARGETS_DN": "Transcription factors down-regulated in LNCaP cells (prostate cancer) by expression of GR [GeneID=2908] off a lentiviral vector.", "YIH_RESPONSE_TO_ARSENITE_C2": "Genes in cluster 2: moderately up-regulated in HFW cells (fibroblast) upon treatment with sodium arsenite [PubChem=26435] at all time points.", "YEGNASUBRAMANIAN_PROSTATE_CANCER": "Genes expressed in at least one prostate cancer cell line but not in normal prostate epithelial cells or stromal cells", "YIH_RESPONSE_TO_ARSENITE_C1": "Genes in cluster 1: strongly up-regulated in HFW cells (fibroblast) upon treatment with sodium arsenite [PubChem=26435] at all time points.", "YIH_RESPONSE_TO_ARSENITE_C3": "Genes in cluster 3: delayed up-regulation in HFW cells (fibroblast) by sodium arsenite [PubChem=26435].", "YIH_RESPONSE_TO_ARSENITE_C4": "Genes in cluster 4: immediate down-regulation in HFW cells (fibroblast) by sodium arsenite [PubChem=26435].", "YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP": "Genes up-regulated in mouse stroma of pancreatic adenocarcinoma zenografts after treatment with HhAntag, a hedgehog (Hh) pathway inhibitor.", "YIH_RESPONSE_TO_ARSENITE_C5": "Genes in cluster 5: slowly down-regulated in HFW cells (fibroblast) by sodium arsenite [PubChem=26435].", "YOKOE_CANCER_TESTIS_ANTIGENS": "Genes up-regulated in both colorectal cancer cells and normal testis relative to normal colon epithelium.", "YUAN_ZNF143_PARTNERS": "Proteins associated with ZNF143 [GeneID=7702] in HeLa cells, based on MudPIT analysis.", "YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_UP": "Genes up-regulated in HUVEC cells (endothelium) by ETS1 [GeneID=2113] which were down-regulated by SP100 [GeneID=6672].", "YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_DN": "Genes down-regulated in HUVEC cells (endothelium) by ETS1 [GeneID=2113] which were up-regulated by SP100 [GeneID=6672].", "ZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS": "An assortment of osteoblast transcriptional regulators.", "YU_BAP1_TARGETS": "Genes deregulated in U2OS cells (osteosarcoma) upon knockdown of BAP1 [GeneID=8314] by RNAi.", "YU_MYC_TARGETS_DN": "Genes down-regulated in B cell lymphoma tumors expressing an activated form of MYC [GeneID=4609].", "YU_MYC_TARGETS_UP": "Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [GeneID=4609].", "ZAMORA_NOS2_TARGETS_DN": "Down-regulated in hepatocytes upon expression of NOS2 [GeneID=4843].", "ZEILSTRA_CD44_TARGETS_DN": "Genes implicated in apoptosis that were down-regulated in duodenum of CD44 [GeneID=960] knockout mice.", "YOSHIMURA_MAPK8_TARGETS_DN": "Genes down-regulated in vascular smooth muscle cells (VSMC) by MAPK8 (JNK1) [GeneID=5599].", "ZAMORA_NOS2_TARGETS_UP": "Up-regulated in hepatocytes upon expression of NOS2 [GeneID=4843].", "ZEILSTRA_CD44_TARGETS_UP": "Genes implicated in apoptosis that were up-regulated in duodenum of CD44 [GeneID=960] knockout mice.", "ZERBINI_RESPONSE_TO_SULINDAC_UP": "Selected genes up-regulated in DU145 and PC-3 cells (prostate cancer) after treatment with the NSAID (non-steroid anti-inflammatory drug) sulindac [PubChem=5352].", "ZERBINI_RESPONSE_TO_SULINDAC_DN": "Selected genes down-regulated in DU145 and PC-3 cells (prostate cancer) after treatment with the NSAID (non-steroid anti-inflammatory drug) sulindac [PubChem=5352].", "YOSHIMURA_MAPK8_TARGETS_UP": "Genes up-regulated in vascular smooth muscle cells (VSMC) by MAPK8 (JNK1) [GeneID=5599].", "ZHANG_ADIPOGENESIS_BY_BMP7": "Genes up-regulated in C3H10T1/2 cells (mesenchyme multipotent cells) upon their differentiation to brown adipocytes in response to BMP7 [GeneID=655].", "ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_DN": "Genes up-regulated in A549 cells (lung carcinoma) upon infection with RSV (respiratory syncytial virus) and down-regulated by further treatment with ribavirin [PubChem=5064].", "ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_UP": "Genes up-regulated in A549 cells (lung carcinoma) upon infection with RSV (respiratory syncytial virus) and up-regulated by further treatment with ribavirin [PubChem=5064].", "ZHANG_GATA6_TARGETS_DN": "Genes down-regulated after cre-lox knockout of GATA6 [GeneID=2627] in airway epithelium.", "ZHANG_BREAST_CANCER_PROGENITORS_DN": "Genes down-regulated in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells.", "ZHANG_GATA6_TARGETS_UP": "Genes up-regulated after cre-lox knockout of GATA6 [GeneID=2627] in airway epithelium.", "ZHANG_BREAST_CANCER_PROGENITORS_UP": "Genes up-regulated in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells.", "ZHANG_PROLIFERATING_VS_QUIESCENT": "Genes up-regulated in HDMEC cells (microvascular endothelium): proliferating vs quiescent cells.", "ZHANG_INTERFERON_RESPONSE": "Interferon-inducible genes up-regulated in A549 cells (lung cancer) infected with a respiratory syncytial virus (RSV) that had its NS1 [GeneID=1494468] gene knocked down by RNAi.", "ZHANG_RESPONSE_TO_CANTHARIDIN_UP": "Genes up-regulated in HL-60 cells (promyeloid leukemia) by cantharidin [PubChem=6708701].", "ZHANG_RESPONSE_TO_CANTHARIDIN_DN": "Genes down-regulated in HL-60 cells (promyeloid leukemia) by cantharidin [PubChem=6708701].", "ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_DN": "Genes down-regulated in BxPC3 cells (pancreatic cancer) after treatment with TNF [GeneID=7124] or IKI-1, an inhibitor of IkappaB kinase (IKK).", "ZHAN_EARLY_DIFFERENTIATION_GENES_UP": "B lymphocyte early differentiation genes (EDG): top genes up-regulated in tonsil B lymphocytes (TBC) compared to the tonsil plasma cells (TPC).", "ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP": "Genes up-regulated in BxPC3 cells (pancreatic cancer) after treatment with TNF [GeneID=7124] or IKI-1, an inhibitor of IkappaB kinase (IKK).", "ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION": "Genes up-regulated in RD-EF cells (rhabdomyosarcoma) engineered to express EWSR1-FLI1 fusion [GeneID=2130;2313] and which are also highly expressed in Ewing's famliy tumors.", "ZHAN_EARLY_DIFFERENTIATION_GENES_DN": "B lymphocyte early differentiation genes (EDG): top genes down-regulated in tonsil B lymphocytes (TBC) compared to the tonsil plasma cells (TPC).", "ZHAN_LATE_DIFFERENTIATION_GENES_DN": "B lymphocyte late differentiation genes (LDG): top genes down-regulated in plasma cells from tonsils (TPC) compared to those from bone marrow (BPC).", "ZHAN_LATE_DIFFERENTIATION_GENES_UP": "B lymphocyte late differentiation genes (LDG): top genes up-regulated in plasma cells from tonsils (TPC) compared to those from bone marrow (BPC).", "ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_DN": "Genes commonly down-regulated in CD-1 and CD-2 clusters of multiple myeloma samples and which were higher expressed in the CD-1 group.", "ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_UP": "Genes commonly up-regulated in CD-1 and CD-2 clusters of multiple myeloma samples and which were higher expressed in the CD-1 group.", "ZHAN_MULTIPLE_MYELOMA_CD1_UP": "Top 50 up-regulated genes in cluster CD-1 of multiple myeloma samples with the characteristic expression spike of CCND1 [GeneID=595].", "ZHAN_MULTIPLE_MYELOMA_CD1_DN": "Top 50 down-regulated genes in cluster CD-1 of multiple myeloma samples with the characteristic expression spike of CCND1 [GeneID=595].", "ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_UP": "Genes up-regulated in CD-1 compared to CD-2 cluster of multiple myeloma samples.", "ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_DN": "Genes down-regulated in CD-1 compared to CD-2 cluster of multiple myeloma samples.", "ZHAN_MULTIPLE_MYELOMA_CD2_DN": "Top 50 down-regulated genes in cluster CD-2 of multiple myeloma samples with the charachteristic expression spike of CCND3 [GeneID=896].", "ZHAN_MULTIPLE_MYELOMA_CD2_UP": "Top 50 up-regulated genes in cluster CD-2 of multiple myeloma samples with the characteristic expression spike of CCND3 [GeneID=896].", "ZHAN_MULTIPLE_MYELOMA_DN": "Genes most significantly down-regulated in multiple myeloma samples, compared to normal bone marrow plasma cells.", "ZHAN_MULTIPLE_MYELOMA_HP_DN": "Top 50 down-regulated genes in cluster HP of multiple myeloma samples characterized by a hyperploid signature.", "ZHAN_MULTIPLE_MYELOMA_HP_UP": "Top 50 up-regulated genes in cluster HP of multiple myeloma samples characterized by a hyperploid signature.", "ZHAN_MULTIPLE_MYELOMA_MF_DN": "Top 50 down-regulated genes in cluster MF of multiple myeloma samples with characteristic expression spike of MAF family transcription factors.", "ZHAN_MULTIPLE_MYELOMA_LB_DN": "Top 50 down-regulated genes in cluster LB of multiple myeloma samples belonging to the low bone disease group.", "ZHAN_MULTIPLE_MYELOMA_LB_UP": "Top 50 up-regulated genes in cluster LB of multiple myeloma samples belonging to the low bone disease group.", "ZHAN_MULTIPLE_MYELOMA_MF_UP": "Top 50 up-regulated genes in cluster MF of multiple myeloma samples with characteristic expression spike of MAF family transcription factors.", "ZHAN_MULTIPLE_MYELOMA_MS_DN": "Top 50 down-regulated genes in cluster MS of multiple myeloma samples with characteristic expression spike of WHSC1 [GeneID=7468].", "ZHAN_MULTIPLE_MYELOMA_MS_UP": "Top 50 up-regulated genes in cluster MS of multiple myeloma samples with characteristic expression spike of WHSC1 [GeneID=7468].", "ZHAN_MULTIPLE_MYELOMA_PR_DN": "Top 50 down-regulated genes in cluster PR of multiple myeloma samples characterized by increased expression of proliferation and cell cycle genes.", "ZHAN_MULTIPLE_MYELOMA_PR_UP": "Top 50 up-regulated genes in cluster PR of multiple myeloma samples characterized by increased expression of proliferation and cell cycle genes.", "ZHAN_MULTIPLE_MYELOMA_SPIKED": "'Spiked' genes: genes most highly up-regulated in multiple myeloma samples; were not differentially expressed as compared to the normal plasma cells.", "ZHAN_MULTIPLE_MYELOMA_SUBGROUPS": "Top genes up-regulated in MM4 vs MM1 subgroup of multiple myeloma samples.", "ZHAN_MULTIPLE_MYELOMA_UP": "Genes most significantly up-regulated in multiple myeloma samples, compared to normal bone marrow plasma cells.", "ZHAN_V1_LATE_DIFFERENTIATION_GENES_DN": "The v1LDG down-regulated set: most variable late differentiation genes (LDG) with similar expression patterns in tonsil plasma cells (TPC) and multiple myeloma (MM) samples.", "ZHAN_V1_LATE_DIFFERENTIATION_GENES_UP": "The v1LDG up-regulated set: most variable late differentiation genes (LDG) with similar expression patterns in tonsil plasma cells (TPC) and multiple myeloma (MM) samples.", "ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_DN": "The vEDG down-regulated set: most variable early differentiation genes (EDG) with similar expression patterns in tonsil B lymphocytes (TBC) and multiple myeloma (MM) cells compared to the plasma cells from tonsil (TPC) and bone marrow (BPC).", "ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_UP": "The vEDG up-regulated set: most variable early differentiation genes (EDG) with similar expression patterns in tonsil B lymphocytes (TBC) and multiple myeloma (MM) cells compared to the plasma cells from tonsil (TPC) and bone marrow (BPC).", "ZHAN_V2_LATE_DIFFERENTIATION_GENES": "The v2LDG set: 50 most variable late differentiation genes (LDG) with similar expression patterns in bone marrow plasma cells (BPC) and multiple myeloma (MM) samples.", "ZHENG_FOXP3_TARGETS_IN_THYMUS_DN": "Genes with promoters bound by FOXP3 [GeneID=50943] and which are down-regulated only in developing (located in the thymus) regulatory CD4+ [GeneID=920] T lymphocytes.", "ZHENG_FOXP3_TARGETS_DN": "Genes with promoters bound by FOXP3 [GeneID=50943] and which are down-regulated both in developing (located in the thymus) and mature (from peripheral blood) regulatory CD4+ [GeneID=920] T lymphocytes.", "ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN": "Genes with promoters bound by FOXP3 [GeneID=50943] and which are down-regulated only in mature (peripheral blood) regulatory CD4+ [GeneID=920] T lymphocytes.", "ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_UP": "Genes with promoters bound by FOXP3 [GeneID=50943] and which are up-regulated only in mature (peripheral blood) regulatory CD4+ [GeneID=920] T lymphocytes.", "ZHENG_FOXP3_TARGETS_IN_THYMUS_UP": "Genes with promoters bound by FOXP3 [GeneID=50943] and which are up-regulated only in developing (located in the thymus) regulatory CD4+ [GeneID=920] T lymphocytes.", "ZHENG_FOXP3_TARGETS_UP": "Genes with promoters bound by FOXP3 [GeneID=50943] and which are up-regulated both in developing (located in the thymus) and mature (from peripheral blood) regulatory CD4+ [GeneID=920] T lymphocytes.", "ZHENG_BOUND_BY_FOXP3": "Genes whose promoters are bound by FOXP3 [GeneID=50943] based an a ChIP-chip analysis.", "ZHENG_GLIOBLASTOMA_PLASTICITY_DN": "The glioblastoma multiforme (GBM) plasticity signature: genes down-regulated in neural stem cells (NSC) with double knockout of TP53 and PTEN [GeneID=7157;5728] vs those with knockout of TP53 alone.", "ZHENG_RESPONSE_TO_ARSENITE_DN": "Down-regulated in HEK293 cells (kidney epithelium) by treatment with sodium arsenite [PubChem=26435].", "ZHENG_IL22_SIGNALING_DN": "Genes down-regulated in ex-vivo colonic tissue after treatment with IL22 [GeneID=50616].", "ZHENG_GLIOBLASTOMA_PLASTICITY_UP": "The glioblastoma multiforme (GBM) plasticity signature: genes up-regulated in neural stem cells (NSC) with double knockout of TP53 and PTEN [GeneID=7157;5728] vs those with knockout of TP53 alone.", "ZHENG_IL22_SIGNALING_UP": "Genes up-regulated in ex-vivo colonic tissue after treatment with IL22 [GeneID=50616].", "ZHENG_RESPONSE_TO_ARSENITE_UP": "Up-regulated in HEK293 cells (kidney epithelium) by treatment with sodium arsenite [PubChem=26435].", "ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM": "Proteins secreted in co-culture of LKR-13 tumor cells (non-small cell lung cancer, NSCLC) and MEC stroma cells (endothelium).", "ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN": "Genes down-regulated in 3 out of 4 NSCLC cell lines (non-small cell lung cancer) after treatment with azacitidine [PubChem=9444] and TSA [PubChem=5562].", "ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP": "Genes up-regulated in 3 out of 4 NSCLC cell lines (non-small cell lung cancer) after treatment with azacitidine [PubChem=9444] and TSA [PubChem=5562].", "ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE": "Proteins secreted in co-culture of LKR-13 tumor cells (non-small cell lung cancer, NSCLC) and MHS stroma cells (macrophages).", "ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST": "Proteins secreted in co-culture of LKR-13 tumor cells (non-small cell lung cancer, NSCLC) and MLg stroma cells (fibroblasts).", "ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_2HR": "Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 2 h after exposure to ionizing radiation.", "ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR": "Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 24 h after exposure to ionizing radiation.", "ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_6HR": "Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 6 h after exposure to ionizing radiation.", "ZHOU_PANCREATIC_BETA_CELL": "Transcription factors expressed in adult pancreatic beta cells.", "ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN": "Genes down-regulated in macrophages by P.gingivalis FimA pathogen.", "ZHOU_PANCREATIC_ENDOCRINE_PROGENITOR": "Transcription factors expressed in progenitors of endocrine pancreatic cells.", "ZHOU_PANCREATIC_EXOCRINE_PROGENITOR": "Transcription factors expressed in progenitors of exocrine pancreatic cells.", "ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP": "Genes up-regulated in macrophages by P.gingivalis FimA pathogen.", "ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN": "Genes down-regulated in macrophage by live P.gingivalis.", "ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP": "Genes up-regulated in macrophage by live P.gingivalis.", "ZHOU_TNF_SIGNALING_30MIN": "Genes up-regulated in HeLa cells (cervical carcinoma) at 30 min after stimulation with TNF [GeneID=7124].", "ZHOU_TNF_SIGNALING_4HR": "Genes up-regulated in HeLa cells (cervical carcinoma) at 4 h after stimulation with TNF [GeneID=7124].", "ZHOU_INFLAMMATORY_RESPONSE_LPS_UP": "Genes up-regulated in macrophages by P.gingivalis LPS (lipopolysaccharide).", "ZHU_CMV_8_HR_UP": "Up-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV", "ZHU_CMV_24_HR_UP": "Up-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV", "ZHU_CMV_24_HR_DN": "Down-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV", "ZHU_CMV_8_HR_DN": "Down-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV", "ZHU_CMV_ALL_UP": "Up-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV", "ZHU_CMV_ALL_DN": "Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV", "ZIRN_TRETINOIN_RESPONSE_DN": "Genes down-regulated in MS427 cells (Wilms tumor with normal WT1 [GeneID=7490]) after treatment with 10 microM tretinoin (ATRA) [PubChem=444795] for 24 h.", "ZHU_SKIL_TARGETS_DN": "Genes down-regulated in A549 cells (lung adenocarcinoma) upon SKIL [GeneID=6498] knockdown by RNAi.", "ZIRN_TRETINOIN_RESPONSE_UP": "Genes up-regulated in MS427 cells (Wilms tumor with normal WT1 [GeneID=7490]) after treatment with 10 microM tretinoin (ATRA) [PubChem=444795] for 24 h.", "ZHU_SKIL_TARGETS_UP": "Genes up-regulated in A549 cells (lung adenocarcinoma) upon SKIL [GeneID=6498] knockdown by RNAi.", "ZIRN_TRETINOIN_RESPONSE_WT1_DN": "Genes down-regulated in MZ128 cells (Wilms tumor with mutated WT1 [GeneID=7490]) after treatment with 10 microM tretinoin (ATRA) [PubChem=444795] for 24 h.", "ZIRN_TRETINOIN_RESPONSE_WT1_UP": "Genes up-regulated in MZ128 cells (Wilms tumor with mutated WT1 [GeneID=7490]) after treatment with 10 microM tretinoin (ATRA) [PubChem=444795] for 24 h.", "ZWANG_CLASS_2_TRANSIENTLY_INDUCED_BY_EGF": "Class II of genes transiently induced by EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF": "Class I of genes transiently induced by EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "ZWANG_DOWN_BY_2ND_EGF_PULSE": "Genes down-regulated by second pulse of EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "ZWANG_EGF_PERSISTENTLY_UP": "Genes persistently induced by EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "SA_B_CELL_RECEPTOR_COMPLEXES": "Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.", "ZWANG_EGF_PERSISTENTLY_DN": "Genes persistently repressed by EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF": "Class III of genes transiently induced by EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "ZWANG_EGF_INTERVAL_DN": "Genes repressed in the time interval between two pulses of EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "ZWANG_EGF_INTERVAL_UP": "Genes induced in the time interval between two pulses of EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "SA_CASPASE_CASCADE": "Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.", "SA_FAS_SIGNALING": "The TNF-type receptor Fas induces apoptosis on ligand binding.", "SA_G1_AND_S_PHASES": "Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.", "SA_G2_AND_M_PHASES": "Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.", "SA_PROGRAMMED_CELL_DEATH": "Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.", "SA_MMP_CYTOKINE_CONNECTION": "Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.", "SA_TRKA_RECEPTOR": "The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.", "SA_REG_CASCADE_OF_CYCLIN_EXPR": "Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.", "SA_PTEN_PATHWAY": "PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.", "SIG_BCR_SIGNALING_PATHWAY": "Members of the BCR signaling pathway", "ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY": "Genes transiently induced only by the second pulse of EGF [GeneID=1950] in 184A1 cells (mammary epithelium).", "SIG_CD40PATHWAYMAP": "Genes related to CD40 signaling", "SIG_CHEMOTAXIS": "Genes related to chemotaxis", "SIG_IL4RECEPTOR_IN_B_LYPHOCYTES": "Genes related to IL4 rceptor signaling in B lymphocytes", "SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES": "Genes related to the insulin receptor pathway", "SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES": "Genes related to PIP3 signaling in B lymphocytes", "WNT_SIGNALING": "Genes related to Wnt-mediated signal transduction", "SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES": "Genes related to PIP3 signaling in cardiac myocytes", "SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES": "Genes related to regulation of the actin cytoskeleton", "BIOCARTA_ACE2_PATHWAY": "Angiotensin-converting enzyme 2 regulates heart function", "BIOCARTA_41BB_PATHWAY": "The 4-1BB-dependent immune response", "BIOCARTA_ACETAMINOPHEN_PATHWAY": "Mechanism of Acetaminophen Activity and Toxicity", "BIOCARTA_ACH_PATHWAY": "Role of nicotinic acetylcholine receptors in the regulation of apoptosis", "BIOCARTA_ACTINY_PATHWAY": "Y branching of actin filaments", "BIOCARTA_AGPCR_PATHWAY": "Attenuation of GPCR Signaling", "BIOCARTA_AKAP13_PATHWAY": "Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation", "BIOCARTA_AGR_PATHWAY": "Agrin in Postsynaptic Differentiation", "BIOCARTA_AHSP_PATHWAY": "Hemoglobin's Chaperone", "BIOCARTA_AKAP95_PATHWAY": "AKAP95 role in mitosis and chromosome dynamics", "BIOCARTA_AKAPCENTROSOME_PATHWAY": "Protein Kinase A at the Centrosome", "BIOCARTA_AKT_PATHWAY": "AKT Signaling Pathway", "BIOCARTA_ALTERNATIVE_PATHWAY": "Alternative Complement Pathway", "BIOCARTA_ALK_PATHWAY": "ALK in cardiac myocytes", "BIOCARTA_AMAN_PATHWAY": "Steps in the Glycosylation of Mammalian N-linked Oligosaccarides", "BIOCARTA_AMI_PATHWAY": "Acute Myocardial Infarction", "BIOCARTA_ASBCELL_PATHWAY": "Antigen Dependent B Cell Activation", "BIOCARTA_ARAP_PATHWAY": "ADP-Ribosylation Factor", "BIOCARTA_ARENRF2_PATHWAY": "Oxidative Stress Induced Gene Expression Via Nrf2", "BIOCARTA_ARF_PATHWAY": "Tumor Suppressor Arf Inhibits Ribosomal Biogenesis", "BIOCARTA_ATM_PATHWAY": "ATM Signaling Pathway", "BIOCARTA_BARD1_PATHWAY": "BRCA1-dependent Ub-ligase activity", "BIOCARTA_BAD_PATHWAY": "Regulation of BAD phosphorylation", "BIOCARTA_AT1R_PATHWAY": "Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling", "BIOCARTA_ATRBRCA_PATHWAY": "Role of BRCA1,  BRCA2 and ATR in Cancer Susceptibility", "BIOCARTA_BARRESTIN_PATHWAY": "b-arrestins in GPCR Desensitization", "BIOCARTA_BARRESTIN_SRC_PATHWAY": "Roles of b-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling", "BIOCARTA_BARR_MAPK_PATHWAY": "Role of b-arrestins in the activation and targeting of MAP kinases", "BIOCARTA_BBCELL_PATHWAY": "Bystander B Cell Activation", "BIOCARTA_BCELLSURVIVAL_PATHWAY": "B Cell Survival Pathway", "BIOCARTA_BOTULIN_PATHWAY": "Blockade of Neurotransmitter Relase by Botulinum Toxin", "BIOCARTA_BLYMPHOCYTE_PATHWAY": "B Lymphocyte Cell Surface Molecules", "BIOCARTA_BIOPEPTIDES_PATHWAY": "Bioactive Peptide Induced Signaling Pathway", "BIOCARTA_CACAM_PATHWAY": "Ca++/ Calmodulin-dependent Protein Kinase Activation", "BIOCARTA_BTG2_PATHWAY": "BTG family proteins and cell cycle regulation", "BIOCARTA_BCR_PATHWAY": "BCR Signaling Pathway", "BIOCARTA_CALCINEURIN_PATHWAY": "Effects of calcineurin in Keratinocyte Differentiation", "BIOCARTA_CARDIACEGF_PATHWAY": "Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy", "BIOCARTA_CARM1_PATHWAY": "Transcription Regulation by Methyltransferase of CARM1", "BIOCARTA_CARM_ER_PATHWAY": "CARM1 and Regulation of the Estrogen Receptor", "BIOCARTA_CB1R_PATHWAY": "Metabolism of Anandamide, an Endogenous Cannabinoid", "BIOCARTA_CASPASE_PATHWAY": "Caspase Cascade in Apoptosis", "BIOCARTA_CBL_PATHWAY": "CBL mediated ligand-induced downregulation of EGF receptors", "BIOCARTA_CCR3_PATHWAY": "CCR3 signaling in Eosinophils", "BIOCARTA_CD40_PATHWAY": "CD40L Signaling Pathway", "BIOCARTA_CCR5_PATHWAY": "Pertussis toxin-insensitive CCR5 Signaling in Macrophage", "BIOCARTA_CDC25_PATHWAY": "cdc25 and chk1 Regulatory Pathway in response to DNA damage", "BIOCARTA_CDK5_PATHWAY": "Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway", "BIOCARTA_CDC42RAC_PATHWAY": "Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration", "BIOCARTA_CDMAC_PATHWAY": "Cadmium induces DNA synthesis and proliferation in macrophages", "BIOCARTA_CELLCYCLE_PATHWAY": "Cyclins and Cell Cycle Regulation", "BIOCARTA_CERAMIDE_PATHWAY": "Ceramide Signaling Pathway", "BIOCARTA_CELL2CELL_PATHWAY": "Cell to Cell Adhesion Signaling", "BIOCARTA_CFTR_PATHWAY": "Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway", "BIOCARTA_CHEMICAL_PATHWAY": "Apoptotic Signaling in Response to DNA Damage", "BIOCARTA_CHREBP_PATHWAY": "ChREBP regulation by carbohydrates and cAMP", "BIOCARTA_CIRCADIAN_PATHWAY": "Circadian Rhythms", "BIOCARTA_CLASSIC_PATHWAY": "Classical Complement Pathway", "BIOCARTA_CK1_PATHWAY": "Regulation of ck1/cdk5 by type 1 glutamate receptors", "BIOCARTA_COMP_PATHWAY": "Complement Pathway", "BIOCARTA_CPSF_PATHWAY": "Polyadenylation of mRNA", "BIOCARTA_CREM_PATHWAY": "Regulation of Spermatogenesis by CREM", "BIOCARTA_CREB_PATHWAY": "Transcription factor CREB and its extracellular signals", "BIOCARTA_CTBP1_PATHWAY": "SUMOylation as a mechanism to modulate CtBP-dependent gene responses", "BIOCARTA_CSK_PATHWAY": "Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor", "BIOCARTA_CTL_PATHWAY": "CTL mediated immune response against target cells", "BIOCARTA_CTCF_PATHWAY": "CTCF: First Multivalent Nuclear Factor", "BIOCARTA_CYTOKINE_PATHWAY": "Cytokine Network", "BIOCARTA_CXCR4_PATHWAY": "CXCR4 Signaling Pathway", "BIOCARTA_CTLA4_PATHWAY": "The Co-Stimulatory Signal During T-cell Activation", "BIOCARTA_DC_PATHWAY": "Dendritic cells in regulating TH1 and TH2 Development", "BIOCARTA_D4GDI_PATHWAY": "D4-GDI Signaling Pathway", "BIOCARTA_DICER_PATHWAY": "Dicer Pathway", "BIOCARTA_DNAFRAGMENT_PATHWAY": "Apoptotic DNA fragmentation and tissue homeostasis", "BIOCARTA_DEATH_PATHWAY": "Induction of apoptosis through DR3 and DR4/5 Death Receptors", "BIOCARTA_DREAM_PATHWAY": "Repression of Pain Sensation by the Transcriptional Regulator DREAM", "BIOCARTA_DSP_PATHWAY": "Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases", "BIOCARTA_EEA1_PATHWAY": "The role of FYVE-finger proteins in vesicle transport", "BIOCARTA_ECM_PATHWAY": "Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia", "BIOCARTA_EDG1_PATHWAY": "Phospholipids as signalling intermediaries", "BIOCARTA_EFP_PATHWAY": "Estrogen-responsive protein Efp controls cell cycle and breast tumors growth", "BIOCARTA_EGFR_SMRTE_PATHWAY": "Map Kinase Inactivation of SMRT Corepressor", "BIOCARTA_EIF2_PATHWAY": "Regulation of eIF2", "BIOCARTA_EGF_PATHWAY": "EGF Signaling Pathway", "BIOCARTA_EICOSANOID_PATHWAY": "Eicosanoid Metabolism", "BIOCARTA_EIF4_PATHWAY": "Regulation of eIF4e and p70 S6 Kinase", "BIOCARTA_EOSINOPHILS_PATHWAY": "The Role of Eosinophils in the Chemokine Network of Allergy", "BIOCARTA_EPHA4_PATHWAY": "Eph Kinases and ephrins support platelet aggregation", "BIOCARTA_EIF_PATHWAY": "Eukaryotic protein translation", "BIOCARTA_EPONFKB_PATHWAY": "Erythropoietin mediated neuroprotection through NF-kB", "BIOCARTA_EPO_PATHWAY": "EPO Signaling Pathway", "BIOCARTA_ERAD_PATHWAY": "ERbassociated degradation (ERAD) Pathway", "BIOCARTA_ERBB3_PATHWAY": "Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling", "BIOCARTA_ERBB4_PATHWAY": "g-Secretase mediated ErbB4 Signaling Pathway", "BIOCARTA_ERYTH_PATHWAY": "Erythrocyte Differentiation Pathway", "BIOCARTA_ERK5_PATHWAY": "Role of Erk5 in Neuronal Survival", "BIOCARTA_ERK_PATHWAY": "Erk1/Erk2 Mapk Signaling pathway", "BIOCARTA_ETC_PATHWAY": "Electron Transport Reaction in Mitochondria", "BIOCARTA_ETS_PATHWAY": "METS affect on Macrophage Differentiation", "BIOCARTA_EXTRINSIC_PATHWAY": "Extrinsic Prothrombin Activation Pathway", "BIOCARTA_FBW7_PATHWAY": "Cyclin E Destruction Pathway", "BIOCARTA_FEEDER_PATHWAY": "Feeder Pathways for Glycolysis", "BIOCARTA_FAS_PATHWAY": "FAS signaling pathway ( CD95 )", "BIOCARTA_FCER1_PATHWAY": "Fc Epsilon Receptor I Signaling in Mast Cells", "BIOCARTA_FIBRINOLYSIS_PATHWAY": "Fibrinolysis Pathway", "BIOCARTA_FOSB_PATHWAY": "FOSB gene expression and drug abuse", "BIOCARTA_FLUMAZENIL_PATHWAY": "Cardiac Protection Against ROS", "BIOCARTA_FREE_PATHWAY": "Free Radical Induced Apoptosis", "BIOCARTA_FXR_PATHWAY": "FXR and LXR Regulation of Cholesterol Metabolism", "BIOCARTA_FMLP_PATHWAY": "fMLP induced chemokine gene expression in HMC-1 cells", "BIOCARTA_GABA_PATHWAY": "Gamma-aminobutyric Acid Receptor Life Cycle", "BIOCARTA_G2_PATHWAY": "Cell Cycle: G2/M Checkpoint", "BIOCARTA_G1_PATHWAY": "Cell Cycle: G1/S Check Point", "BIOCARTA_GHRELIN_PATHWAY": "Ghrelin: Regulation of Food Intake and Energy Homeostasis", "BIOCARTA_GATA3_PATHWAY": "GATA3 participate in activating the Th2 cytokine genes expression", "BIOCARTA_GCR_PATHWAY": "Corticosteroids and cardioprotection", "BIOCARTA_GH_PATHWAY": "Growth Hormone Signaling Pathway", "BIOCARTA_GLEEVEC_PATHWAY": "Inhibition of Cellular Proliferation by Gleevec", "BIOCARTA_GRANULOCYTES_PATHWAY": "Adhesion and Diapedesis of Granulocytes", "BIOCARTA_GPCR_PATHWAY": "Signaling Pathway from G-Protein Families", "BIOCARTA_HBX_PATHWAY": "Calcium Signaling by HBx of Hepatitis B virus", "BIOCARTA_GSK3_PATHWAY": "Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages", "BIOCARTA_HDAC_PATHWAY": "Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)", "BIOCARTA_HCMV_PATHWAY": "Human Cytomegalovirus and Map Kinase Pathways", "BIOCARTA_HES_PATHWAY": "Segmentation Clock", "BIOCARTA_HER2_PATHWAY": "Role of ERBB2 in Signal Transduction and Oncology", "BIOCARTA_HIF_PATHWAY": "Hypoxia-Inducible Factor in the Cardiovascular System", "BIOCARTA_HSP27_PATHWAY": "Stress Induction of HSP Regulation", "BIOCARTA_HIVNEF_PATHWAY": "HIV-I Nef: negative effector of Fas and TNF", "BIOCARTA_IFNA_PATHWAY": "IFN alpha signaling pathway", "BIOCARTA_HSWI_SNF_PATHWAY": "Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes", "BIOCARTA_IFNG_PATHWAY": "IFN gamma signaling pathway", "BIOCARTA_IL10_PATHWAY": "IL-10 Anti-inflammatory Signaling Pathway", "BIOCARTA_IGF1_PATHWAY": "IGF-1 Signaling Pathway", "BIOCARTA_IGF1R_PATHWAY": "Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation", "BIOCARTA_IGF1MTOR_PATHWAY": "Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway", "BIOCARTA_IL17_PATHWAY": "IL 17 Signaling Pathway", "BIOCARTA_IL12_PATHWAY": "IL12 and Stat4 Dependent Signaling Pathway in Th1 Development", "BIOCARTA_IL22BP_PATHWAY": "IL22 Soluble Receptor Signaling Pathway", "BIOCARTA_IL2RB_PATHWAY": "IL-2 Receptor Beta Chain in T cell Activation", "BIOCARTA_IL2_PATHWAY": "IL 2 signaling pathway", "BIOCARTA_IL3_PATHWAY": "IL 3 signaling pathway", "BIOCARTA_IL4_PATHWAY": "IL 4 signaling pathway", "BIOCARTA_IL1R_PATHWAY": "Signal transduction through IL1R", "BIOCARTA_IL5_PATHWAY": "IL 5 Signaling Pathway", "BIOCARTA_IL6_PATHWAY": "IL 6 signaling pathway", "BIOCARTA_INFLAM_PATHWAY": "Cytokines and Inflammatory Response", "BIOCARTA_IL7_PATHWAY": "IL-7 Signal Transduction", "BIOCARTA_INSULIN_PATHWAY": "Insulin Signaling Pathway", "BIOCARTA_ION_PATHWAY": "Ion Channel and Phorbal Esters Signaling Pathway", "BIOCARTA_INTEGRIN_PATHWAY": "Integrin Signaling Pathway", "BIOCARTA_INTRINSIC_PATHWAY": "Intrinsic Prothrombin Activation Pathway", "BIOCARTA_IRES_PATHWAY": "Internal Ribosome entry pathway", "BIOCARTA_KREB_PATHWAY": "The Citric Acid Cycle", "BIOCARTA_KERATINOCYTE_PATHWAY": "Keratinocyte Differentiation", "BIOCARTA_LAIR_PATHWAY": "Cells and Molecules involved in local acute inflammatory response", "BIOCARTA_LECTIN_PATHWAY": "Lectin Induced Complement Pathway", "BIOCARTA_LDL_PATHWAY": "Low-density lipoprotein (LDL) pathway during atherogenesis", "BIOCARTA_LEPTIN_PATHWAY": "Reversal of Insulin Resistance by Leptin", "BIOCARTA_LIS1_PATHWAY": "Lissencephaly gene (LIS1) in neuronal migration and development", "BIOCARTA_LYMPHOCYTE_PATHWAY": "Adhesion Molecules on Lymphocyte", "BIOCARTA_MALATEX_PATHWAY": "Shuttle for transfer of acetyl groups from mitochondria to the cytosol", "BIOCARTA_LONGEVITY_PATHWAY": "The IGF-1 Receptor and Longevity", "BIOCARTA_LYM_PATHWAY": "Adhesion and Diapedesis of Lymphocytes", "BIOCARTA_MAL_PATHWAY": "Role of MAL in Rho-Mediated Activation of SRF", "BIOCARTA_MCM_PATHWAY": "CDK Regulation of DNA Replication", "BIOCARTA_MAPK_PATHWAY": "MAPKinase Signaling Pathway", "BIOCARTA_MCALPAIN_PATHWAY": "mCalpain and friends in Cell motility", "BIOCARTA_MELANOCYTE_PATHWAY": "Melanocyte Development and Pigmentation Pathway", "BIOCARTA_MEF2D_PATHWAY": "Role of MEF2D in T-cell Apoptosis", "BIOCARTA_MHC_PATHWAY": "Antigen Processing and Presentation", "BIOCARTA_MET_PATHWAY": "Signaling of Hepatocyte Growth Factor Receptor", "BIOCARTA_MITR_PATHWAY": "Signal Dependent Regulation of Myogenesis by Corepressor MITR", "BIOCARTA_MITOCHONDRIA_PATHWAY": "Role of Mitochondria in Apoptotic Signaling", "BIOCARTA_MONOCYTE_PATHWAY": "Monocyte and its Surface Molecules", "BIOCARTA_MSP_PATHWAY": "Msp/Ron Receptor Signaling Pathway", "BIOCARTA_MRP_PATHWAY": "Multi-Drug Resistance Factors", "BIOCARTA_MPR_PATHWAY": "How Progesterone Initiates the Oocyte Maturation", "BIOCARTA_MTA3_PATHWAY": "Downregulated of MTA-3 in ER-negative Breast Tumors", "BIOCARTA_MTOR_PATHWAY": "mTOR Signaling Pathway", "BIOCARTA_MYOSIN_PATHWAY": "PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase", "BIOCARTA_NDKDYNAMIN_PATHWAY": "Endocytotic role of NDK, Phosphins and Dynamin", "BIOCARTA_NEUTROPHIL_PATHWAY": "Neutrophil and Its Surface Molecules", "BIOCARTA_NFAT_PATHWAY": "NFAT and Hypertrophy of the heart (Transcription in the broken heart)", "BIOCARTA_NFKB_PATHWAY": "NF-kB Signaling Pathway", "BIOCARTA_NGF_PATHWAY": "Nerve growth factor pathway (NGF)", "BIOCARTA_NKCELLS_PATHWAY": "Ras-Independent pathway in NK cell-mediated cytotoxicity", "BIOCARTA_NKT_PATHWAY": "Selective expression of chemokine receptors during T-cell polarization", "BIOCARTA_NO2IL12_PATHWAY": "NO2-dependent IL 12 Pathway in NK cells", "BIOCARTA_NO1_PATHWAY": "Actions of Nitric Oxide in the Heart", "BIOCARTA_NPC_PATHWAY": "Mechanism of Protein Import into the Nucleus", "BIOCARTA_NOTCH_PATHWAY": "Proteolysis and Signaling Pathway of Notch", "BIOCARTA_NOS1_PATHWAY": "Nitric Oxide Signaling Pathway", "BIOCARTA_NPP1_PATHWAY": "Regulators of Bone Mineralization", "BIOCARTA_NTHI_PATHWAY": "NFkB activation by Nontypeable Hemophilus influenzae", "BIOCARTA_P27_PATHWAY": "Regulation of p27 Phosphorylation during Cell Cycle Progression", "BIOCARTA_P35ALZHEIMERS_PATHWAY": "Deregulation of CDK5 in Alzheimers Disease", "BIOCARTA_NUCLEARRS_PATHWAY": "Nuclear Receptors in Lipid Metabolism and Toxicity", "BIOCARTA_P38MAPK_PATHWAY": "p38 MAPK Signaling Pathway", "BIOCARTA_PARKIN_PATHWAY": "Role of Parkin in the Ubiquitin-Proteasomal Pathway", "BIOCARTA_P53HYPOXIA_PATHWAY": "Hypoxia and p53 in the Cardiovascular system", "BIOCARTA_P53_PATHWAY": "p53 Signaling Pathway", "BIOCARTA_PAR1_PATHWAY": "Thrombin signaling and protease-activated receptors", "BIOCARTA_PCAF_PATHWAY": "The information-processing pathway at the IFN-beta enhancer", "BIOCARTA_PDZS_PATHWAY": "Synaptic Proteins at the Synaptic Junction", "BIOCARTA_PDGF_PATHWAY": "PDGF Signaling Pathway", "BIOCARTA_PELP1_PATHWAY": "Pelp1 Modulation of Estrogen Receptor Activity", "BIOCARTA_PLATELETAPP_PATHWAY": "Platelet Amyloid Precursor Protein Pathway", "BIOCARTA_PEPI_PATHWAY": "Proepithelin Conversion to Epithelin and Wound Repair Control", "BIOCARTA_PGC1A_PATHWAY": "Regulation of PGC-1a", "BIOCARTA_PKC_PATHWAY": "Activation of PKC through G protein coupled receptor", "BIOCARTA_PLCD_PATHWAY": "Phospholipase C d1 in phospholipid associated cell signaling", "BIOCARTA_PITX2_PATHWAY": "Multi-step Regulation of Transcription by Pitx2", "BIOCARTA_PLCE_PATHWAY": "Phospholipase C-epsilon pathway", "BIOCARTA_PLC_PATHWAY": "Phospholipase C Signaling Pathway", "BIOCARTA_PLK3_PATHWAY": "Regulation of cell cycle progression by Plk3", "BIOCARTA_PPARG_PATHWAY": "Role of PPAR-gamma Coactivators in Obesity and Thermogenesis", "BIOCARTA_PRC2_PATHWAY": "The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails", "BIOCARTA_PML_PATHWAY": "Regulation of transcriptional activity by PML", "BIOCARTA_PPARA_PATHWAY": "Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)", "BIOCARTA_PROTEASOME_PATHWAY": "Proteasome Complex", "BIOCARTA_PRION_PATHWAY": "Prion Pathway", "BIOCARTA_PTC1_PATHWAY": "Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle", "BIOCARTA_PS1_PATHWAY": "Presenilin action in Notch and Wnt signaling", "BIOCARTA_PTDINS_PATHWAY": "Phosphoinositides and their downstream targets.", "BIOCARTA_PTEN_PATHWAY": "PTEN dependent cell cycle arrest and apoptosis", "BIOCARTA_PYK2_PATHWAY": "Links between Pyk2 and Map Kinases", "BIOCARTA_RAB_PATHWAY": "Rab GTPases Mark Targets In The Endocytotic Machinery", "BIOCARTA_RANBP2_PATHWAY": "Sumoylation by RanBP2 Regulates Transcriptional Repression", "BIOCARTA_RANKL_PATHWAY": "Bone Remodelling", "BIOCARTA_RACCYCD_PATHWAY": "Influence of Ras and Rho proteins on G1 to S Transition", "BIOCARTA_RAC1_PATHWAY": "Rac 1 cell motility signaling pathway", "BIOCARTA_RACC_PATHWAY": "Ion Channels and Their Functional Role in Vascular Endothelium", "BIOCARTA_RARRXR_PATHWAY": "Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells", "BIOCARTA_RAN_PATHWAY": "Cycling of Ran in nucleocytoplasmic transport", "BIOCARTA_RANMS_PATHWAY": "Role of Ran in mitotic spindle regulation", "BIOCARTA_RAS_PATHWAY": "Ras Signaling Pathway", "BIOCARTA_RECK_PATHWAY": "Inhibition of Matrix Metalloproteinases", "BIOCARTA_RB_PATHWAY": "RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage", "BIOCARTA_RELA_PATHWAY": "Acetylation and Deacetylation of RelA in The Nucleus", "BIOCARTA_REELIN_PATHWAY": "Reelin Signaling Pathway", "BIOCARTA_RHODOPSIN_PATHWAY": "Visual Signal Transduction", "BIOCARTA_RNA_PATHWAY": "Double Stranded RNA Induced Gene Expression", "BIOCARTA_S1P_PATHWAY": "SREBP control of lipid synthesis", "BIOCARTA_RNAPOL3_PATHWAY": "RNA polymerase III transcription", "BIOCARTA_RHO_PATHWAY": "Rho cell motility signaling pathway", "BIOCARTA_SALMONELLA_PATHWAY": "How does salmonella hijack a cell", "BIOCARTA_SAM68_PATHWAY": "Regulation of Splicing through Sam68", "BIOCARTA_SET_PATHWAY": "Granzyme A mediated Apoptosis Pathway", "BIOCARTA_SARS_PATHWAY": "SARS Coronavirus Protease", "BIOCARTA_SHH_PATHWAY": "Sonic Hedgehog (Shh) Pathway", "BIOCARTA_SKP2E2F_PATHWAY": "E2F1 Destruction Pathway", "BIOCARTA_SLRP_PATHWAY": "Small Leucine-rich Proteoglycan (SLRP) molecules", "BIOCARTA_SODD_PATHWAY": "SODD/TNFR1 Signaling Pathway", "BIOCARTA_SM_PATHWAY": "Spliceosomal Assembly", "BIOCARTA_SRCRPTP_PATHWAY": "Activation of Src by Protein-tyrosine phosphatase alpha", "BIOCARTA_SPPA_PATHWAY": "Aspirin Blocks Signaling Pathway Involved in Platelet Activation", "BIOCARTA_SPRY_PATHWAY": "Sprouty regulation of tyrosine kinase signals", "BIOCARTA_STAT3_PATHWAY": "Stat3 Signaling Pathway", "BIOCARTA_STATHMIN_PATHWAY": "Stathmin and breast cancer resistance to antimicrotubule agents", "BIOCARTA_STRESS_PATHWAY": "TNF/Stress Related Signaling", "BIOCARTA_STEM_PATHWAY": "Regulation of hematopoiesis by cytokines", "BIOCARTA_TCAPOPTOSIS_PATHWAY": "HIV Induced T Cell Apoptosis", "BIOCARTA_SUMO_PATHWAY": "Basic Mechanisms of SUMOylation", "BIOCARTA_TCRA_PATHWAY": "Lck and Fyn tyrosine kinases in initiation of TCR Activation", "BIOCARTA_TALL1_PATHWAY": "TACI and BCMA stimulation of B cell immune responses.", "BIOCARTA_TCYTOTOXIC_PATHWAY": "T Cytotoxic Cell Surface Molecules", "BIOCARTA_TERC_PATHWAY": "Overview of telomerase RNA component gene hTerc Transcriptional Regulation", "BIOCARTA_TEL_PATHWAY": "Telomeres, Telomerase, Cellular Aging, and  Immortality", "BIOCARTA_TCR_PATHWAY": "T Cell Receptor Signaling Pathway", "BIOCARTA_THELPER_PATHWAY": "T Helper Cell Surface Molecules", "BIOCARTA_TERT_PATHWAY": "Overview of telomerase protein component gene hTert Transcriptional Regulation", "BIOCARTA_TFF_PATHWAY": "Trefoil Factors Initiate  Mucosal Healing", "BIOCARTA_TH1TH2_PATHWAY": "Th1/Th2 Differentiation", "BIOCARTA_TGFB_PATHWAY": "TGF beta signaling pathway", "BIOCARTA_TID_PATHWAY": "Chaperones modulate interferon Signaling Pathway", "BIOCARTA_TNFR1_PATHWAY": "TNFR1 Signaling Pathway", "BIOCARTA_TNFR2_PATHWAY": "TNFR2 Signaling Pathway", "BIOCARTA_TOLL_PATHWAY": "Toll-Like Receptor Pathway", "BIOCARTA_TOB1_PATHWAY": "Role of Tob in T-cell activation", "BIOCARTA_TSP1_PATHWAY": "TSP-1 Induced Apoptosis in Microvascular Endothelial Cell", "BIOCARTA_TPO_PATHWAY": "TPO Signaling Pathway", "BIOCARTA_UCALPAIN_PATHWAY": "uCalpain and friends in Cell spread", "BIOCARTA_TRKA_PATHWAY": "Trka Receptor Signaling Pathway", "BIOCARTA_TUBBY_PATHWAY": "G-Protein Signaling Through Tubby Proteins", "BIOCARTA_VDR_PATHWAY": "Control of Gene Expression by Vitamin D Receptor", "BIOCARTA_VEGF_PATHWAY": "VEGF, Hypoxia, and Angiogenesis", "BIOCARTA_VIP_PATHWAY": "Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells", "BIOCARTA_VOBESITY_PATHWAY": "Visceral Fat Deposits and the Metabolic Syndrome", "BIOCARTA_VITCB_PATHWAY": "Vitamin C in the Brain", "BIOCARTA_WNT_LRP6_PATHWAY": "Wnt/LRP6 Signalling", "BIOCARTA_WNT_PATHWAY": "WNT Signaling Pathway", "KEGG_ABC_TRANSPORTERS": "ABC transporters", "KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY": "Adipocytokine signaling pathway", "KEGG_ACUTE_MYELOID_LEUKEMIA": "Acute myeloid leukemia", "KEGG_ADHERENS_JUNCTION": "Adherens junction", "KEGG_ALPHA_LINOLENIC_ACID_METABOLISM": "alpha-Linolenic acid metabolism", "KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM": "Alanine, aspartate and glutamate metabolism", "KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION": "Aldosterone-regulated sodium reabsorption", "KEGG_ALLOGRAFT_REJECTION": "Allograft rejection", "KEGG_ALZHEIMERS_DISEASE": "Alzheimer's disease", "KEGG_AMINOACYL_TRNA_BIOSYNTHESIS": "Aminoacyl-tRNA biosynthesis", "KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS": "Amyotrophic lateral sclerosis (ALS)", "KEGG_APOPTOSIS": "Apoptosis", "KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION": "Antigen processing and presentation", "KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM": "Amino sugar and nucleotide sugar metabolism", "KEGG_ASCORBATE_AND_ALDARATE_METABOLISM": "Ascorbate and aldarate metabolism", "KEGG_ARGININE_AND_PROLINE_METABOLISM": "Arginine and proline metabolism", "KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC": "Arrhythmogenic right ventricular cardiomyopathy (ARVC)", "KEGG_ARACHIDONIC_ACID_METABOLISM": "Arachidonic acid metabolism", "KEGG_ASTHMA": "Asthma", "KEGG_AUTOIMMUNE_THYROID_DISEASE": "Autoimmune thyroid disease", "KEGG_AXON_GUIDANCE": "Axon guidance", "KEGG_BASAL_CELL_CARCINOMA": "Basal cell carcinoma", "KEGG_BASAL_TRANSCRIPTION_FACTORS": "Basal transcription factors", "KEGG_BASE_EXCISION_REPAIR": "Base excision repair", "KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS": "Biosynthesis of unsaturated fatty acids", "KEGG_BETA_ALANINE_METABOLISM": "beta-Alanine metabolism", "KEGG_BUTANOATE_METABOLISM": "Butanoate metabolism", "KEGG_BLADDER_CANCER": "Bladder cancer", "KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY": "B cell receptor signaling pathway", "KEGG_CALCIUM_SIGNALING_PATHWAY": "Calcium signaling pathway", "KEGG_CELL_ADHESION_MOLECULES_CAMS": "Cell adhesion molecules (CAMs)", "KEGG_CARDIAC_MUSCLE_CONTRACTION": "Cardiac muscle contraction", "KEGG_CIRCADIAN_RHYTHM_MAMMAL": "Circadian rhythm - mammal", "KEGG_CELL_CYCLE": "Cell cycle", "KEGG_CHRONIC_MYELOID_LEUKEMIA": "Chronic myeloid leukemia", "KEGG_CITRATE_CYCLE_TCA_CYCLE": "Citrate cycle (TCA cycle)", "KEGG_CHEMOKINE_SIGNALING_PATHWAY": "Chemokine signaling pathway", "KEGG_COLORECTAL_CANCER": "Colorectal cancer", "KEGG_COMPLEMENT_AND_COAGULATION_CASCADES": "Complement and coagulation cascades", "KEGG_CYSTEINE_AND_METHIONINE_METABOLISM": "Cysteine and methionine metabolism", "KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY": "Cytosolic DNA-sensing pathway", "KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION": "Cytokine-cytokine receptor interaction", "KEGG_DILATED_CARDIOMYOPATHY": "Dilated cardiomyopathy", "KEGG_DORSO_VENTRAL_AXIS_FORMATION": "Dorso-ventral axis formation", "KEGG_DNA_REPLICATION": "DNA replication", "KEGG_DRUG_METABOLISM_CYTOCHROME_P450": "Drug metabolism - cytochrome P450", "KEGG_ECM_RECEPTOR_INTERACTION": "ECM-receptor interaction", "KEGG_DRUG_METABOLISM_OTHER_ENZYMES": "Drug metabolism - other enzymes", "KEGG_ENDOMETRIAL_CANCER": "Endometrial cancer", "KEGG_ENDOCYTOSIS": "Endocytosis", "KEGG_ETHER_LIPID_METABOLISM": "Ether lipid metabolism", "KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION": "Epithelial cell signaling in Helicobacter pylori infection", "KEGG_ERBB_SIGNALING_PATHWAY": "ErbB signaling pathway", "KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY": "Fc epsilon RI signaling pathway", "KEGG_FATTY_ACID_METABOLISM": "Fatty acid metabolism", "KEGG_FOLATE_BIOSYNTHESIS": "Folate biosynthesis", "KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS": "Fc gamma R-mediated phagocytosis", "KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM": "Fructose and mannose metabolism", "KEGG_GALACTOSE_METABOLISM": "Galactose metabolism", "KEGG_FOCAL_ADHESION": "Focal adhesion", "KEGG_GAP_JUNCTION": "Gap junction", "KEGG_GLIOMA": "Glioma", "KEGG_GLYCEROLIPID_METABOLISM": "Glycerolipid metabolism", "KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM": "Glycine, serine and threonine metabolism", "KEGG_GLUTATHIONE_METABOLISM": "Glutathione metabolism", "KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE": "Glycosaminoglycan biosynthesis - chondroitin sulfate", "KEGG_GLYCOLYSIS_GLUCONEOGENESIS": "Glycolysis / Gluconeogenesis", "KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE": "Glycosaminoglycan biosynthesis - keratan sulfate", "KEGG_GLYCEROPHOSPHOLIPID_METABOLISM": "Glycerophospholipid metabolism", "KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE": "Glycosaminoglycan biosynthesis - heparan sulfate", "KEGG_GLYCOSAMINOGLYCAN_DEGRADATION": "Glycosaminoglycan degradation", "KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES": "Glycosphingolipid biosynthesis - ganglio series", "KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES": "Glycosphingolipid biosynthesis - globo series", "KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES": "Glycosphingolipid biosynthesis - lacto and neolacto series", "KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM": "Glyoxylate and dicarboxylate metabolism", "KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS": "Glycosylphosphatidylinositol(GPI)-anchor biosynthesis", "KEGG_HEDGEHOG_SIGNALING_PATHWAY": "Hedgehog signaling pathway", "KEGG_GNRH_SIGNALING_PATHWAY": "GnRH signaling pathway", "KEGG_HEMATOPOIETIC_CELL_LINEAGE": "Hematopoietic cell lineage", "KEGG_HOMOLOGOUS_RECOMBINATION": "Homologous recombination", "KEGG_GRAFT_VERSUS_HOST_DISEASE": "Graft-versus-host disease", "KEGG_HISTIDINE_METABOLISM": "Histidine metabolism", "KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM": "Hypertrophic cardiomyopathy (HCM)", "KEGG_INOSITOL_PHOSPHATE_METABOLISM": "Inositol phosphate metabolism", "KEGG_HUNTINGTONS_DISEASE": "Huntington's disease", "KEGG_INSULIN_SIGNALING_PATHWAY": "Insulin signaling pathway", "KEGG_LIMONENE_AND_PINENE_DEGRADATION": "Limonene and pinene degradation", "KEGG_LINOLEIC_ACID_METABOLISM": "Linoleic acid metabolism", "KEGG_JAK_STAT_SIGNALING_PATHWAY": "Jak-STAT signaling pathway", "KEGG_LEISHMANIA_INFECTION": "Leishmania infection", "KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION": "Leukocyte transendothelial migration", "KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION": "Intestinal immune network for IgA production", "KEGG_LONG_TERM_POTENTIATION": "Long-term potentiation", "KEGG_LONG_TERM_DEPRESSION": "Long-term depression", "KEGG_LYSINE_DEGRADATION": "Lysine degradation", "KEGG_LYSOSOME": "Lysosome", "KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG": "Maturity onset diabetes of the young", "KEGG_MELANOGENESIS": "Melanogenesis", "KEGG_MISMATCH_REPAIR": "Mismatch repair", "KEGG_MAPK_SIGNALING_PATHWAY": "MAPK signaling pathway", "KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450": "Metabolism of xenobiotics by cytochrome P450", "KEGG_MELANOMA": "Melanoma", "KEGG_MTOR_SIGNALING_PATHWAY": "mTOR signaling pathway", "KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM": "Nicotinate and nicotinamide metabolism", "KEGG_NEUROTROPHIN_SIGNALING_PATHWAY": "Neurotrophin signaling pathway", "KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION": "Neuroactive ligand-receptor interaction", "KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY": "Natural killer cell mediated cytotoxicity", "KEGG_NITROGEN_METABOLISM": "Nitrogen metabolism", "KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY": "NOD-like receptor signaling pathway", "KEGG_NON_HOMOLOGOUS_END_JOINING": "Non-homologous end-joining", "KEGG_NON_SMALL_CELL_LUNG_CANCER": "Non-small cell lung cancer", "KEGG_NOTCH_SIGNALING_PATHWAY": "Notch signaling pathway", "KEGG_NUCLEOTIDE_EXCISION_REPAIR": "Nucleotide excision repair", "KEGG_ONE_CARBON_POOL_BY_FOLATE": "One carbon pool by folate", "KEGG_N_GLYCAN_BIOSYNTHESIS": "N-Glycan biosynthesis", "KEGG_OOCYTE_MEIOSIS": "Oocyte meiosis", "KEGG_OTHER_GLYCAN_DEGRADATION": "Other glycan degradation", "KEGG_O_GLYCAN_BIOSYNTHESIS": "O-Glycan biosynthesis", "KEGG_OXIDATIVE_PHOSPHORYLATION": "Oxidative phosphorylation", "KEGG_OLFACTORY_TRANSDUCTION": "Olfactory transduction", "KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS": "Pantothenate and CoA biosynthesis", "KEGG_P53_SIGNALING_PATHWAY": "p53 signaling pathway", "KEGG_PANCREATIC_CANCER": "Pancreatic cancer", "KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS": "Pentose and glucuronate interconversions", "KEGG_PARKINSONS_DISEASE": "Parkinson's disease", "KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION": "Pathogenic Escherichia coli infection", "KEGG_PENTOSE_PHOSPHATE_PATHWAY": "Pentose phosphate pathway", "KEGG_PEROXISOME": "Peroxisome", "KEGG_PHENYLALANINE_METABOLISM": "Phenylalanine metabolism", "KEGG_PATHWAYS_IN_CANCER": "Pathways in cancer", "KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM": "Porphyrin and chlorophyll metabolism", "KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM": "Phosphatidylinositol signaling system", "KEGG_PPAR_SIGNALING_PATHWAY": "PPAR signaling pathway", "KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS": "Primary bile acid biosynthesis", "KEGG_PRIMARY_IMMUNODEFICIENCY": "Primary immunodeficiency", "KEGG_PRION_DISEASES": "Prion diseases", "KEGG_PROPANOATE_METABOLISM": "Propanoate metabolism", "KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION": "Proximal tubule bicarbonate reclamation", "KEGG_PROSTATE_CANCER": "Prostate cancer", "KEGG_PROTEIN_EXPORT": "Protein export", "KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION": "Progesterone-mediated oocyte maturation", "KEGG_PROTEASOME": "Proteasome", "KEGG_PYRIMIDINE_METABOLISM": "Pyrimidine metabolism", "KEGG_PURINE_METABOLISM": "Purine metabolism", "KEGG_PYRUVATE_METABOLISM": "Pyruvate metabolism", "KEGG_REGULATION_OF_AUTOPHAGY": "Regulation of autophagy", "KEGG_REGULATION_OF_ACTIN_CYTOSKELETON": "Regulation of actin cytoskeleton", "KEGG_RENIN_ANGIOTENSIN_SYSTEM": "Renin-angiotensin system", "KEGG_RIBOFLAVIN_METABOLISM": "Riboflavin metabolism", "KEGG_RETINOL_METABOLISM": "Retinol metabolism", "KEGG_RENAL_CELL_CARCINOMA": "Renal cell carcinoma", "KEGG_RIBOSOME": "Ribosome", "KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY": "RIG-I-like receptor signaling pathway", "KEGG_RNA_POLYMERASE": "RNA polymerase", "KEGG_RNA_DEGRADATION": "RNA degradation", "KEGG_SELENOAMINO_ACID_METABOLISM": "Selenoamino acid metabolism", "KEGG_SMALL_CELL_LUNG_CANCER": "Small cell lung cancer", "KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT": "SNARE interactions in vesicular transport", "KEGG_SPHINGOLIPID_METABOLISM": "Sphingolipid metabolism", "KEGG_STARCH_AND_SUCROSE_METABOLISM": "Starch and sucrose metabolism", "KEGG_STEROID_BIOSYNTHESIS": "Steroid biosynthesis", "KEGG_SPLICEOSOME": "Spliceosome", "KEGG_SULFUR_METABOLISM": "Sulfur metabolism", "KEGG_STEROID_HORMONE_BIOSYNTHESIS": "Steroid hormone biosynthesis", "KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS": "Systemic lupus erythematosus", "KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM": "Taurine and hypotaurine metabolism", "KEGG_TASTE_TRANSDUCTION": "Taste transduction", "KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS": "Terpenoid backbone biosynthesis", "KEGG_TGF_BETA_SIGNALING_PATHWAY": "TGF-beta signaling pathway", "KEGG_THYROID_CANCER": "Thyroid cancer", "KEGG_TIGHT_JUNCTION": "Tight junction", "KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY": "Toll-like receptor signaling pathway", "KEGG_TRYPTOPHAN_METABOLISM": "Tryptophan metabolism", "KEGG_TYPE_II_DIABETES_MELLITUS": "Type II diabetes mellitus", "KEGG_TYPE_I_DIABETES_MELLITUS": "Type I diabetes mellitus", "KEGG_TYROSINE_METABOLISM": "Tyrosine metabolism", "KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY": "T cell receptor signaling pathway", "KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS": "Valine, leucine and isoleucine biosynthesis", "KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS": "Ubiquitin mediated proteolysis", "KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION": "Valine, leucine and isoleucine degradation", "KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION": "Vascular smooth muscle contraction", "KEGG_VEGF_SIGNALING_PATHWAY": "VEGF signaling pathway", "KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION": "Vasopressin-regulated water reabsorption", "KEGG_VIBRIO_CHOLERAE_INFECTION": "Vibrio cholerae infection", "KEGG_MEDICUS_ENV_FACTOR_ARSENIC_TO_ELECTRON_TRANSFER_IN_COMPLEX_IV": "Pathway Definition from KEGG: As -- AS3MT >> GSTO1 -> MMA -| CxIV", "KEGG_VIRAL_MYOCARDITIS": "Viral myocarditis", "KEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM": "Pathway Definition from KEGG: B[a]P -- (CYP1A1,CYP1B1) >> EH >> AKR -> C22355 -> Semiquinone -> Superoxide", "KEGG_MEDICUS_ENV_FACTOR_DCE_TO_DNA_ADDUCTS": "Pathway Definition from KEGG: DCE -- GST -> C20304 -> C14874 == DNA", "KEGG_WNT_SIGNALING_PATHWAY": "Wnt signaling pathway", "KEGG_MEDICUS_ENV_FACTOR_E2_TO_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: E2 -> ESR1/2 => (EGF,FGF9,DLL)", "KEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: E2 -> ESR1/2 -> SRC -> RAS -> RAF -> MEK -> ERK -> (ESR1/2,AP1) => CHRNA9", "KEGG_MEDICUS_ENV_FACTOR_IRON_TO_ANTEROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: Fe2+ -> CDK5 -> MAPT -| (TUBA+TUBB)", "KEGG_MEDICUS_ENV_FACTOR_METALS_TO_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Metals -> ROS -| PTP -| SRC -> ABL -> PKD -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY": "Pathway Definition from KEGG: Metals -> ROS -| KEAP1 -| NRF2 => (HMOX1,NQO1,AKR)", "KEGG_MEDICUS_ENV_FACTOR_METALS_TO_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Metals -> ROS -> MAP3K5 -> MKK4/7 -> JNK -> AP1", "KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Metals -> ROS -> RAS -> RAF -> MEK -> ERK -> AP1", "KEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (Nicotine,NNK) -> ADRB2 -> GNAI -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_ENV_FACTOR_NICOTINE_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Nicotine -> (CHRNA4+CHRNB2) -> JAK2 -> STAT3 => CCND1", "KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_CHRNA7_E2F_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (NNK,NNN) -> CHRNA7 -> ARRB1 -> SRC -> RAF1 -> RB1 // E2F1 => (BIRC5,XIAP,CDC6,CDC25A)", "KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339": "Pathway Definition from KEGG: (NNK,NNN) -> CHRNA7 -> Ca2+ -> PI3K -> PIP3 -> AKT -> (MTOR,NFKB,BIRC5)", "KEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS": "Pathway Definition from KEGG: NNK -- (AKR1C2,CBR1,HSD11B1) >> (CYP2A6,CYP2A13) -> C19577 -> C19568 -> C20302 == DNA", "KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (NNK,NNN) -> CHRN -> Ca2+ -> RAS -> RAF -> MEK -> ERK -> (FOS,JUN,MYC,BCL2)", "KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350": "Pathway Definition from KEGG: (NNK,NNN) -> CHRNA9 -> PI3K -> PIP3 -> AKT -> (ESR1/2,AP1) => (CHRNA9,CCND3)", "KEGG_MEDICUS_ENV_FACTOR_PARAQUAT_TO_FAS_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PQ -> ROS -| TRX1 -| ASK1 -> JNK", "KEGG_MEDICUS_ENV_FACTOR_PHIP_TO_DNA_ADDUCTS": "Pathway Definition from KEGG: PhIP -- CYP1A2 >> SULT1A -> N-sulfonyloxy-PhIP == DNA", "KEGG_MEDICUS_ENV_FACTOR_ZN_TO_ANTEROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: Zn2+ -> GSK3B -> MAPT -| (TUBA+TUBB)", "KEGG_MEDICUS_PATHOGEN_ARSENIC_TO_ELECTRON_TRANSFER_IN_COMPLEX_II": "Pathway Definition from KEGG: As -- AS3MT >> GSTO1 -> MMA -| CxII", "KEGG_MEDICUS_ENV_FACTOR_TCDD_TO_AHR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TCDD -> (AHR+ARNT) => (CYP1A1,CYP1B1,GST)", "KEGG_MEDICUS_PATHOGEN_EBV_BARF1_TO_INTRINSIC_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: BARF1 -> BCL2 -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_PATHOGEN_EBV_EBNA1_TO_P53_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: EBNA1 -| USP7 -> TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)", "KEGG_MEDICUS_PATHOGEN_EBV_EBNA2_TO_RBP_JK_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: EBNA2 == SNW1 -> RBPJ => (LMP1,CR2,HES1,FCER2,RUNX3,MYC)", "KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_CELL_CYCLE_G1_S_N00483": "Pathway Definition from KEGG: EBNA3C -> (CCND+CDK4/6) -> RB1 // E2F", "KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_CELL_CYCLE_G1_S_N00484": "Pathway Definition from KEGG: EBNA3C -> SKP2 -> RB1 // E2F", "KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P27_CELL_CYCLE_G1_S_N00264": "Pathway Definition from KEGG: EBNA3C -> SKP2 -| CDKN1B -| ((CCNA,CCNE)+CDK2) -> RB1 // E2F", "KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P27_CELL_CYCLE_G1_S_N00482": "Pathway Definition from KEGG: EBNA3C -> ((CCNA,CCNE)+CDK2) -> RB1 // E2F", "KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P53_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: EBNA3C -> MDM2 -| TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)", "KEGG_MEDICUS_PATHOGEN_EBV_LMP1_TO_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: LMP1 -> (TRADD+TRAF6) -> (TAB1/2+TAK1) -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_PATHOGEN_EBV_LMP2A_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: LMP2A -> (LYN,SYK) -> PI3K", "KEGG_MEDICUS_PATHOGEN_EBV_LMP1_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: LMP1 -> (TRAF3,TRAF5) -> PI3K", "KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_EAE_TIR_TCCP_TO_ACTIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Eae -> Tir -> (IRTKS,IRSp53) -> TccP -> WASL -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_EAE_TIR_TO_ACTIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Eae -> Tir -> NCK -> (WASL+WIPF) -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPG_TO_MICROTUBULE_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (EspG,EspG2) -| (TUBA+TUBB)", "KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPJ_TO_IGG_FCGR_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EspJ -| SRC -> FCGR", "KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_MAP_TO_CDC42_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Map -> CDC42 -> WASL -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPT_TO_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EspT -> RAC1 -> (WASF2+ABI1) -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_TIR_TO_TLR2_4_MAPK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Tir -> SHP1/2 -| (TRAF6+TAK1+TAB2)", "KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_MAP_TO_LPA_GNA12_13_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Map -> NHERF1 -> EZR -> RHOA -> ROCK1/2", "KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_CREB_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: X -> CREBBP == (CREB+ATF2) => (CXCL8,PCNA)", "KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: X -> ERK -> AP1 => MMP9", "KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: X -> SRC -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> ELK1", "KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: S -> PKC -> RAF -> MEK -> ERK -> AP1", "KEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: UL55 -> PDGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_PATHOGEN_HCMV_GH_TO_ITGA_B_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: UL75 -> (ITGAV+ITGB3) -> SRC -> RAC -| RHOA", "KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: UL33 -> (GNAQ,GNA11) -> PLCB", "KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: UL33 -> (GNAI,GNAO) -| ADCY -> cAMP -> PKA -> CREB", "KEGG_MEDICUS_PATHOGEN_HCMV_US27_TO_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: US27 -> Ca2+ -> PKC -> PTK2B -> (PTK2+BCAR1+CRK+PXN)", "KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNB_G_RHO_SIGNALING_PATHWAY": "Pathway Definition from KEGG: UL33 -> GNB/G -> RHOA -> MAP2K6 -> p38 -> CREB", "KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: US28 -> GNAQ -> PLCB -> IP3 -> Ca2+ -> CALM == CN -> NFAT => (CXCL8,PTGS2)", "KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNA12_13_RHO_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (CCL2,CCL3,CCL4,CCL5,CX3CL1) -> US28 -> GNA12/13 -> (ARHGEF12,ARHGEF1) -> RHOA -> ROCK1/2 -> CTNNB1", "KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: US28 -> GNB/G -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB => (IL6,CXCL8)", "KEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Core -| YWHA -| RAF -> MEK -> ERK", "KEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_RXRA_PPARA_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: Core -> (RXRA+PPARA) => (CCND1,CDK4,MYC)", "KEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_RXRA_LXRA_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: (Core+PSME3) -> (RXRA+NR1H3) => (CCND1,CDK4,MYC)", "KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN": "Pathway Definition from KEGG: Env -> (CXCR4,CCR5) -> GNAQ -> PLCG -> IP3 -> Ca2+ -> CALM == CN -> NFAT", "KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_TNF_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Env -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Env -> (CXCR4,CCR5) -> GNAI -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Env -> (CXCR4,CCR5) -> GNB/G -> RAC -> PAK1 -> LIMK1 -> CFL", "KEGG_MEDICUS_PATHOGEN_HIV_NEF_TO_TNF_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Nef -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_PATHOGEN_HIV_TAT_NEF_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS": "Pathway Definition from KEGG: (Tat,Nef) -> CASP8 -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_PATHOGEN_HIV_TAT_TO_TLR2_4_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Tat -> NFKB => (TNF,IFNA,IFNB1)", "KEGG_MEDICUS_PATHOGEN_HIV_VPR_TAT_TO_TNF_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (Vpr,Tat) -> JNK -> AP1", "KEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_WEE1_CELL_CYCLE_G2M": "Pathway Definition from KEGG: Vpr -> WEE1 -| (CCNB+CDK1)", "KEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_CDC25_CELL_CYCLE_G2M": "Pathway Definition from KEGG: Vpr == (DCAF1+DDB1+CUL4) -> ATR -> CHEK1 -| CDC25C -> (CCNB+CDK1)", "KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_I_MOLECULES": "Pathway Definition from KEGG: E5 -| (MHCI+BCAP31)", "KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: E5 -| V-ATPase -| EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381": "Pathway Definition from KEGG: E6 -| MFNG -| NOTCH -> (NICD+RBPJ+MAML) => (HES1,HEY1)", "KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380": "Pathway Definition from KEGG: E6 -> JAG1 -> NOTCH -> (NICD+RBPJ+MAML) => (HES1,HEY1)", "KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382": "Pathway Definition from KEGG: E6 -> (NFX1+PSEN1) -> NOTCH -> (NICD+RBPJ+MAML) => (HES1,HEY1)", "KEGG_MEDICUS_PATHOGEN_HPV_E7_TO_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: E7 -> (RB1,RBL1,RBL2) // E2F", "KEGG_MEDICUS_PATHOGEN_HPV_E7_TO_P27_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: E7 -> (CCNE+CDK2) -> RB1 // E2F", "KEGG_MEDICUS_PATHOGEN_HSV_GD_TO_HVEM_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GD -> TNFRSF14 -> TRAF2/5 -> IKK -> NFKBIA -> NFKB => (BIRC2,BIRC3,NFKB1,RELA,CCL2)", "KEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_I_MOLECULES": "Pathway Definition from KEGG: P12 -| (MHCI+B2M)", "KEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: P12 -> IL2RB/G -> JAK1/3 -> STAT5 => IL2", "KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_NFY_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: TAX -> NFYB => MHCII", "KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_E47_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: TAX -| E47 => (POLB,LCK,BAX,CDKN2C)", "KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00497": "Pathway Definition from KEGG: TAX -| TP53 => CDKN1A -| (CDK2+CCNE) -> RB1 // E2F", "KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00498": "Pathway Definition from KEGG: TAX -| CDKN1A -| (CDK2+CCNE) -> RB1 // E2F", "KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_SPINDLE_ASSEMBLY_CHECKPOINT_SIGNALING": "Pathway Definition from KEGG: TAX -> (ANAPC+CDC20) -| PTTG -| ESPL1", "KEGG_MEDICUS_PATHOGEN_KSHV_K15_TO_TNF_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: K15 -> TRAF2 -> TAK1 -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_PATHOGEN_KSHV_LANA_TO_WNT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: LANA -| GSK3B -| CTNNB1 -> TCF/LEF => CCND1", "KEGG_MEDICUS_PATHOGEN_KSHV_MIR1_2_TO_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_I_MOLECULES": "Pathway Definition from KEGG: (MIR1,MIR2) -| MHCI", "KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_SRF_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: TAX -> SRF => (FOS,FOSL1,EGR1,EGR2)", "KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_TNF_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TAX -> (MAPK8,MAPK9,MAPK10) -> JUN => MMP7", "KEGG_MEDICUS_PATHOGEN_KSHV_MIR2_TO_CELL_SURFACE_MOLECULE_ENDOCYTOSIS": "Pathway Definition from KEGG: MIR2 -| (ICAM1,CD86,MICA,MICB,CLEC2B,IFNGR1)", "KEGG_MEDICUS_PATHOGEN_KSHV_VCYCLIN_TO_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: vCyclin -> CDK4/6 -> RB1 // E2F", "KEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_TNF_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: vFLIP -> TRAF2 -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: vFLIP -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: vGPCR -> GNB/G -> RAS -> RAF1 -> MEK -> ERK -> (HIF1A,FOS,JUN) => (VEGFA,PDGFB,ANGPT2)", "KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_AKT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: vGPCR -> GNB/G -> PI3Kgamma -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: vGPCR -> GNB/G -> PI3Kgamma -> PREX1 -> RAC1 -> JNK -> NFKB => (IL6,CXCL8)", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES": "Pathway Definition from KEGG: SifA == PLEKHM1 == RAB7 == HOPS", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_AVRA_TO_BETA_CATENIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: AvrA -> CTNNB1 -> TCF/LEF => MYC", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT": "Pathway Definition from KEGG: SifA -> PLEKHM2 == (KIF5+KLC) == (TUBA+TUBB)", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SopB -> (PIK3CA/B/G/D,PIK3C2B) -> PIP3 -> ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SopB -> RHOA -> ROCK2 -> MLC", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_E2_TO_NOD_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SopE/E2 -> CDC42 -> NOD1 -> RIPK2 -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_RHOG_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SopB -> ARHGEF26 -> RHOG -> ELMO", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SopE -> RAC1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_SALMONELLA_SPVD_TO_TNF_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SpvD -| XPO2 -> (KPNA1+KPNA3) -> NFKB", "KEGG_MEDICUS_PATHOGEN_SARS_COV_2_S_N_TO_LECTIN_PATHWAY_OF_COAGULATION_CASCADE": "Pathway Definition from KEGG: (S,N) -> (MBL2,COLEC10/11,FCN)", "KEGG_MEDICUS_PATHOGEN_SARS_COV_2_S_TO_ANGII_AT1R_NOX2_SIGNALING_PATHWAY": "Pathway Definition from KEGG: S -| ACE2 -| AngII -> AGTR1 -> NOX2 -> ROS -> NFKB -> (TNF,IL6,IL1B,IL12,MMP3,MMP1,CCL2,CXCL8)", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAA_TO_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IpaA -> RHOA -> ROCK1/2 -> MLC", "KEGG_MEDICUS_PATHOGEN_SARS_COV_2_S_TO_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE": "Pathway Definition from KEGG: S -> (IgG,IgM) -> ((C1QA,C1QB,C1QC)+C1R+C1S))", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_FIMA_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS": "Pathway Definition from KEGG: FimA -> VDAC1 == HK -| BAX", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAB_C_D_TO_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (IpaB+IpaC,IpaD) -> (ITGA5+ITGB1) -> (PTK2+PXN) -> (TLN+VCN) -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAH7.8_TO_NLRP3_INFLAMMASOME_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IpaH7.8 -| GLMN -| (NLRP3+PYCARD) -> CASP1 -> IL1B", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGB1_TO_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IpgB1 -> (DOCK1+ELMO) -> RAC1", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAC_TO_ACTIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IpaC -> SRC -> CTTN -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPF_TO_TLR2_4_MAPK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: OspF -| (ERK,p38)", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPG_TO_TNF_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: OspG -| (UBE2D2+(RBX1+CUL1+SKP1)+FBXW1/11) -> NFKBIA", "KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IpgD -> PI(5)P -> PI3K -> PIP3 -> ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_PATHOGEN_YERSINIA_YOPH_TO_TCR_NFAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: YopH -| (SLP76,LAT,VAV)", "KEGG_MEDICUS_PATHOGEN_YERSINIA_YOPP_J_TO_TLR2_4_MAPK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: YopP/J -| (MEK,MKK3/6,MKK4/7)", "KEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ACh -> CHRNA7 -> Ca2+ -> PI3K -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_26S_PROTEASOME_MEDIATED_PROTEIN_DEGRADATION": "Pathway Definition from KEGG: (Protein+UB) -- 26S -> Peptide", "KEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ACh -> CHRNA7 -> Ca2+ -> RAS -> RAF -> MEK -> ERK -> CREB", "KEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119": "Pathway Definition from KEGG: PRC1.1 -- (USP7+TRIM27) -- H2AK119+UB -> PRC2.2", "KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ACTH -> (MC2R+MRAP) -> GNAS -> ADCY -> cAMP -> PKA -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol", "KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: INHBA -> ((ACVR2A,ACVR2B)+(ACVR1B,ACVR1C)) -> (SMAD2,SMAD3) == SMAD4", "KEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119_IN_GERMLINE_GENES": "Pathway Definition from KEGG: PRC1.6 -- (MGA,MAX+L3MBTL2+E2F6) -- H2AK119+UB -> PRC2.2", "KEGG_MEDICUS_REFERENCE_AHR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: KA -> (AHR+ARNT) => (IL6,IL22,PTGS2,VEGFA,CYP1A1,CYP1B1)", "KEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: AGE -> AGER -> RAS -> RAF -> MEK -> ERK -> NFKB => (TNF,IL6,NOS2)", "KEGG_MEDICUS_REFERENCE_ALTERNATIVE_PATHWAY_OF_COMPLEMENT_CASCADE_C3B_BREAKDOWN": "Pathway Definition from KEGG: (C3b+Bb) -- (CFH,(CD55+CR1)) -> C3b -- (CFI+(CFH,CR1,CD46)) -> iC3b -- (CFI+CR1) -> C3dg -- Plasmin -> C3d", "KEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ADRB3 -> GNAS -> ADCY -> cAMP -> PKA -> JMD1A+SWI/SNF+PPARG => UCP1", "KEGG_MEDICUS_REFERENCE_ANGII_AT1R_NOX2_SIGNALING_PATHWAY": "Pathway Definition from KEGG: AngII -> AGTR1 -> NOX2 -> ROS -> NFKB -> (VCAM1,IL6,MMP2,MMP9)", "KEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: AMH -> (AMHR2+(ACVR1,BMPR1A,BMPR1B)) -> (SMAD1,SMAD5,SMAD9) == SMAD4", "KEGG_MEDICUS_REFERENCE_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: AngII -> AGTR1 -> GNAQ -> PLCB -> IP3 -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone", "KEGG_MEDICUS_REFERENCE_ANTEROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: (KIF5+KLC) == (TUBA+TUBB)", "KEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_I_MOLECULES": "Pathway Definition from KEGG: TAP1/2 == TAPBP == (PDIA3+CALR) -> (MHCI+B2M)", "KEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_II_MOLECULES": "Pathway Definition from KEGG: CD74 -> MHCII", "KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: AREG -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_REFERENCE_ANXA2_S100A10_REGULATED_ACTIN_CYTOSKELETON": "Pathway Definition from KEGG: (ANXA2+S100A10) == AHNAK == (ACTB,ACTG1)", "KEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: AREG -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_REFERENCE_ASSEMBLY_AND_TRAFFICKING_OF_TELOMERASE": "Pathway Definition from KEGG: TERC+TERT+Pontin+Reptin == DKC1+NOP10+NHP2+GAR1+NAF1 -> TERC+TERT+Pontin+Reptin+Dyskerins == WRAP53+TriC", "KEGG_MEDICUS_REFERENCE_ATR_P21_CELL_CYCLE_G2_M": "Pathway Definition from KEGG: (ATM,ATR) -> CHEK1 -> TP53 => CDKN1A -| (CDK1+CCNB)", "KEGG_MEDICUS_REFERENCE_ARL8_REGULATED_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT": "Pathway Definition from KEGG: BORCS == ARL8 == PLEKHM2 == (KIF5+KLC) == (TUBA+TUBB)", "KEGG_MEDICUS_REFERENCE_ATR_SIGNALING": "Pathway Definition from KEGG: RPA == RAD17+9-1-1 == TOPBP1 == ATR+ATRIP -> CHEK1", "KEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TETHERING_FACTOR": "Pathway Definition from KEGG: RAB7 == (EPG5,PLEKHM1,BIRC6,HOPS,TECPR2) == LC3-II", "KEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TETHERING_FACTOR_GRASP55": "Pathway Definition from KEGG: LAMP2 == GORASP2 == LC3-II", "KEGG_MEDICUS_REFERENCE_AUTOPHAGOSOME_AND_LYSOSOME_FUSION_TRANS_SNARE": "Pathway Definition from KEGG: (VAMP8,STX7) == SNAP29 == (STX17,YKT6)", "KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_E3_UBIQUITIN_LIGASE_MALIN": "Pathway Definition from KEGG: (EPM2A+NHLRC1) -> (BECN1,PIK3C3,PIK3R4,ATG14,UVRAG)", "KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_MTORC1_PI3KC3_C1": "Pathway Definition from KEGG: mTORC1 -> ULK1_complex -> PI3KC3-C1", "KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_PACER_RUBCN_PI3KC3_C2": "Pathway Definition from KEGG: RUBCNL -| RUBCN -| PI3KC3-C2", "KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_LC3_II_FORMATION": "Pathway Definition from KEGG: LC3 -- ATG4 >> ATG7 >> ATG3 >> (ATG12+ATG5+ATG16L1) -> LC3-II", "KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_SEQUESTOSOME_1_LIKE_RECEPTOR": "Pathway Definition from KEGG: Ubiquitinated_protein == (SQSTM1,NBR1,OPTN,CALCOCO2,TAX1BP1,WDFY3) == LC3-II", "KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_PI3P_SYNTHESIS_BY_PI3KC3_C1": "Pathway Definition from KEGG: PI -- PI3KC3-C1 -> PI3P -> (WIPI,ZFYVE1)", "KEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: AVP -> AVPR2 -> GNAS -> ADCY3/6/9 -> cAMP -> PKA -> AQP2", "KEGG_MEDICUS_REFERENCE_BASE_EXCISION_AND_STRAND_CLEAVAGE_BY_BIFUNCTIONAL_GLYCOSYLASE": "Pathway Definition from KEGG: glycosylase -> APEX == POLB+XRCC1 == PARP,PARG,ADPRS", "KEGG_MEDICUS_REFERENCE_BASE_EXCISION_AND_STRAND_CLEAVAGE_BY_MONOFUNCTIONAL_GLYCOSYLASE": "Pathway Definition from KEGG: glycosylase -> APEX == POLB", "KEGG_MEDICUS_REFERENCE_BASE_EXCISION_AND_STRAND_CLEAVAGE_BY_NEIL_GLYCOSYLASE": "Pathway Definition from KEGG: glycosylase -> TDP1+PNKP == POLB+XRCC1 == PARP", "KEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGH -> (LYN,SYK) -> (PIK3AP1,(CD19+CD21+CD81+IFITM1)) -> PI3Kdelta -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGH -> (LYN,SYK) -> (BTK,BLNK) -> PLCG2 -> IP3 -> Ca2+ -> CALM == CN -> NFAT", "KEGG_MEDICUS_REFERENCE_BETA_OXIDATION": "Pathway Definition from KEGG: Acyl-CoA(n) -- (ACADM,ACADL,ACADVL,ACADS,ACADSB) >> ((ECHS1+HADH),HADHA) >> (ACAA2,HADHB,ACAT1) -> Acyl-CoA(n-2)", "KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGH -> (LYN,SYK) -> (BTK,BLNK) -> PLCG2 -> IP3 -> ITPR -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_BETA_OXIDATION_ACYL_COA_SYNTHESIS": "Pathway Definition from KEGG: Palmitate -- (ACSL,ACSBG) >> CPT1A/B/C >> CPT2 -> Palmitoyl-CoA", "KEGG_MEDICUS_REFERENCE_BETA_OXIDATION_PEROXISOME_VLCFA": "Pathway Definition from KEGG: Very-long-chain-acyl-CoA(n) -- ACOX1/3 >> HSD17B4 >> (ACAA1,SCP2) -> Very-long-chain-acyl-CoA(n-2)", "KEGG_MEDICUS_REFERENCE_BLOCKING_UBIQUITINATION_OF_H2AK119_BY_CK2": "Pathway Definition from KEGG: CK2 -| PRC1.3,PRC1.5 -- H2AK119+UB", "KEGG_MEDICUS_REFERENCE_BILE_ACID_BIOSYNTHESIS": "Pathway Definition from KEGG: Cholesterol -- (CYP7A1,CYP7B1,CYP39A1) >> HSD3B7 >> CYP8B1 >> AKR1D1 >> AKR1C4 >> CYP27A1 >> SLC27A5 >> AMACR >> ACOX2 >> HSD17B4 >> SCP2 >> ACOT8 -> Cholate", "KEGG_MEDICUS_REFERENCE_BLOOD_GROUP_H_O_ANTIGEN_TYPE_1_BIOSYNTHESIS": "Pathway Definition from KEGG: LacCer -- B3GNT5 >> B3GALT1/2/5 -> Lc4Cer -- FUT2*H -> TypeIH // ABO*O", "KEGG_MEDICUS_REFERENCE_BLOOD_GROUP_H_O_ANTIGEN_TYPE_2_BIOSYNTHESIS": "Pathway Definition from KEGG: LacCer -- B3GNT5 >> B4GALT1/2/3/4 -> nLc4Cer -- FUT1*H -> TypeIIH // ABO*O", "KEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY": "Pathway Definition from KEGG: BMP15 -> (BMPR2+BMPR1B) -> (SMAD1,SMAD5,SMAD9) == SMAD4", "KEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY_AUXILIARY_FACTOR": "Pathway Definition from KEGG: (HJV,HFE,TFR2) -> ((ACVR2B,BMPR2)+(ACVR1,BMPR1A))", "KEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY": "Pathway Definition from KEGG: BMP2/6 -> ((ACVR2B,BMPR2)+(ACVR1,BMPR1A) -> (SMAD1,SMAD5,SMAD9) == SMAD4 => HAMP", "KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY": "Pathway Definition from KEGG: BMP -> ((ACVR2A,ACVR2B,BMPR2)+(BMPR1A,BMPR1B,ACVR1)) -> (SMAD1,SMAD5,SMAD9) == SMAD4", "KEGG_MEDICUS_REFERENCE_BREAK_INDUCED_REPLICATION": "Pathway Definition from KEGG: POLD3 == PIF1,MCM", "KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY_BMP_ANTAGONIST": "Pathway Definition from KEGG: (NOG,GREM,CHRD,NBL1) -| BMP", "KEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY": "Pathway Definition from KEGG: BMP9/10 -> ((BMPR2,ACVR2A)+ACVRL1) -> (SMAD1,SMAD5,SMAD9) == SMAD4", "KEGG_MEDICUS_REFERENCE_C9ORF72_MEDIATED_AUTOPHAGY_INITIATION": "Pathway Definition from KEGG: RAB1A -> (C9orf72+WDR41+SMCR8) -> ULK1_complex", "KEGG_MEDICUS_REFERENCE_CA2_CAM_CAMK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Ca2+(cyto) -> CALM == CAMK", "KEGG_MEDICUS_REFERENCE_BRANCHING_MICROTUBULE_NUCLEATION": "Pathway Definition from KEGG: gamma-TuRC == Augumin == TPX2+microtubule", "KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Ca2+(cyto) == CALM == (CAV,RYR)", "KEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Ca2+(cyto) -> CALM == CN -> NFAT", "KEGG_MEDICUS_REFERENCE_CA2_ENTRY_LIGAND_GATED_CA2_CHANNEL": "Pathway Definition from KEGG: Ca2+(extracellular) -- LGCC -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_CA2_ENTRY_STORE_OPERATED_CA2_CHANNEL": "Pathway Definition from KEGG: Ca2+(er/sr) -| STIM -> ORAI -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL": "Pathway Definition from KEGG: Ca2+(extracellular) -- CAV -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Ca2+ -> PTK2B -> SRC -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Ca2+(cyto) -> PLCD -> IP3 -> ITPR -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_CARDIAC_TYPE_VGCC_RYR_SIGNALING": "Pathway Definition from KEGG: Ca2+(extracellular) -- CAV1.2 -> Ca2+(cyto) -> (RYR2+TRDN+JCN+CASQ) -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_CASR_PTH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Ca2+ -> CASR -> GNAQ -> PLCB -> IP3 -> Ca2+ -| PTH", "KEGG_MEDICUS_REFERENCE_CCR2_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CCL2 -> CCR2 -> GNB/G -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (CD80,CD86) -> CD28 -> PI3K -> PIP3 -> AKT -| GSK3B", "KEGG_MEDICUS_REFERENCE_CCR5_GNB_G_PLCB_G_PKC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CCL5 -> CCR5 -> GNB/G -> PLCB -> (Ca2+,DAG) -> PKC", "KEGG_MEDICUS_REFERENCE_CD40_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CD40LG -> CD40 -> (TRAF2+TRAF3) -> NIK -> IKKA -> (NFKB2+RELB)", "KEGG_MEDICUS_REFERENCE_CCR_CXCR_GNB_G_PI3K_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (CC,CXC) -> (CCR,CXCR) -> GNB/G -> PI3Kgamma -> PREX1 -> RAC1", "KEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (CD80,CD86) -> CTLA4 -> PP2A -| AKT", "KEGG_MEDICUS_REFERENCE_CDC25_CELL_CYCLE_G2_M": "Pathway Definition from KEGG: (ATM,ATR) -> CHEK1/2 -| CDC25B/C -> (CCNB+CDK1)", "KEGG_MEDICUS_REFERENCE_CENPE_INTERACTION_WITH_NDC80_COMPLEX": "Pathway Definition from KEGG: (AURKA,AURKB) -| PP1 -- CENPE+(SKAP+Astrin) == NDC80C", "KEGG_MEDICUS_REFERENCE_CGAS_STING_SIGNALING_PATHWAY": "Pathway Definition from KEGG: DNA -> CGAS -> cGAMP -> STING1 -> TBK1 -> IRF3 => (IFNA,IFNB)", "KEGG_MEDICUS_REFERENCE_CHONDROITIN_SULFATE_BIOSYNTHESIS": "Pathway Definition from KEGG: G00157 -- CSGALNACT1/2 >> CHSY1/3,CHPF -> Chondroitin -- CHST3/7 -> Chondroitin_6-sulfate", "KEGG_MEDICUS_REFERENCE_CHOLESTEROL_BIOSYNTHESIS": "Pathway Definition from KEGG: Farnesyl-PP -- FDFT1 >> SQLE >> LSS >> CYP51A1 >> (TM7SF2,LBR) >> MSMO1 >> NSDHL >> HSD17B7 >> DHCR24 >> EBP >> SC5D -> 7-DHC -- DHCR7 -> Cholesterol", "KEGG_MEDICUS_REFERENCE_CHRNA7_E2F_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ACh -> CHRNA7 -> ARRB1 -> SRC -> RAF1 -> RB1 // E2F1", "KEGG_MEDICUS_REFERENCE_CITRATE_CYCLE_FIRST_CARBON_OXIDATION": "Pathway Definition from KEGG: OA+AcCoA -- (CS,ACLY) >> ACO1/2 >> IDH -> 2OG", "KEGG_MEDICUS_REFERENCE_CITRATE_CYCLE_SECOND_CARBON_OXIDATION_2": "Pathway Definition from KEGG: SucCoA -- SUCL >> SDH >> FH >> MDH1/2 -> OA", "KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION": "Pathway Definition from KEGG: [C4,C2] -- ((C1QA,C1QB,C1QC)+C1R+C1S) -> [C4b,C2a] -> (C4b+C2a)", "KEGG_MEDICUS_REFERENCE_COHESIN_ACETYLATION": "Pathway Definition from KEGG: HDAC8 -| ESCO1,ESCO2 -- SMC3 -> CDCA5", "KEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_ANAPHASE": "Pathway Definition from KEGG: ANAPC+CDC20 -| PTTG1 -| ESPL1 -| RAD21", "KEGG_MEDICUS_REFERENCE_COHESIN_LOADING": "Pathway Definition from KEGG: Cohesin -> ATRX == Cohesin == NIPBL+MAU2 -> DDX11 == Cohesin+NIPBL+MAU2", "KEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE": "Pathway Definition from KEGG: SGO1+PP2A -| PLK1,AURKB,CDK1 -- STAG+CDCA5", "KEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING": "Pathway Definition from KEGG: PP2A == Condensin_II -> TOP2A+KIF4A+DNMT3B == Condensin_I", "KEGG_MEDICUS_REFERENCE_COMMON_PATHWAY_OF_COMPLEMENT_CASCADE_MAC_FORMATION": "Pathway Definition from KEGG: C5 -- ((C4b+C2a+C3b),(C3b+Bb+C3b)) -> C5b -> (C5b+C6+C7+C8+C9)", "KEGG_MEDICUS_REFERENCE_COPII_VESICLE_FORMATION": "Pathway Definition from KEGG: SEC12 -> SAR1 == (SEC23+SEC24) == (SEC13+SEC31)", "KEGG_MEDICUS_REFERENCE_COPI_VESICLE_FORMATION": "Pathway Definition from KEGG: GBF1 -> ARF1 == (KDELR+TMED2+TMED10) == (COPI+TMED4/9+TMED1/3/5/6/7)", "KEGG_MEDICUS_REFERENCE_CORE_NER_REACTION": "Pathway Definition from KEGG: (ERCC3+ERCC2+GTF2H) == ERCC5 == XPA == RPA -> (ERCC1+ERCC4) == XPA == RPA == ERCC5 -> PCNA == POLD,POLE,POLK,POLH -> LIG1,(LIG3+XRCC1)", "KEGG_MEDICUS_REFERENCE_CREATINE_PATHWAY": "Pathway Definition from KEGG: Arg+Gly -- GATM >> GAMT -> Cr -- CK -> Crn", "KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CRH -> CRHR -> GNAS -> ADCY -> cAMP -> PKA -> CREB -> ACTH", "KEGG_MEDICUS_REFERENCE_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS": "Pathway Definition from KEGG: (FASLG,TNFSF10) -> (FAS,TNFRSF10B) -> FADD -> (CASP8,CASP10) -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)", "KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY": "Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG) -> IP3 -> Ca2+ -> PKC -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CX3CL1 -> CX3CR1 -> GNAI -| ADCY -> cAMP -> PKA", "KEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNAI -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_REFERENCE_CXCR4_GNA12_13_RHO_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNA12/13 -> (ARHGEF12,ARHGEF1) -> RHOA -> ROCK1/2", "KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNB/G -> PLCB -> (Ca2+,DAG) -> PKC -> PTK2B -> (PTK2+BCAR1+CRK+PXN)", "KEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG) -> IP3 -> Ca2+ -> CALM == CN -> NFAT", "KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CXCL8 -> CXCR2 -> GNB/G -> RAS -> RAF1 -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNB/G -> RAC -> PAK1 -> LIMK1 -> CFL", "KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_PI3K_AKT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CXCL8 -> CXCR2 -> GNB/G -> PI3Kgamma -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_REFERENCE_CYTOKINE_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Cytokine -> Receptor -> JAK -> STAT => PIM1", "KEGG_MEDICUS_REFERENCE_DERMATAN_SULFATE_DEGRADATION": "Pathway Definition from KEGG: DS -- IDS >> IDUA >> ARSB >> HYAL -> G00872", "KEGG_MEDICUS_REFERENCE_DEPHOSPHORYLATION_OF_KINETOCHORE": "Pathway Definition from KEGG: NDC80C == (SKA1+SKA2+SKA3) == PP1 -| (MPS1,AURKB)", "KEGG_MEDICUS_REFERENCE_DISASSEMBLY_OF_MCC": "Pathway Definition from KEGG: TRIP13+MAD2L1BP -| MCC -| ANAPC", "KEGG_MEDICUS_REFERENCE_DEUBIQUITINATION_OF_H2AK119": "Pathway Definition from KEGG: PR-DUB -| cPRC1", "KEGG_MEDICUS_REFERENCE_DNA_DEGRADATION_BY_EXTRACELLULAR_ENDOLYSOSOMAL_DNASE": "Pathway Definition from KEGG: (TREX1,DNASE1,DNASE2) -| DNA", "KEGG_MEDICUS_REFERENCE_DNA_END_RESECTION_AND_RPA_LOADING": "Pathway Definition from KEGG: MRN == CtIP == BRCA1+BARD1 == UIMC1+ABRAXAS+BABAM1+BRE+BRCC3 -> BLM,WRN+DNA2+MRN == RPA", "KEGG_MEDICUS_REFERENCE_DNA_REPLICATION_TERMINATION": "Pathway Definition from KEGG: CMG+PIF1 -> CMG+CRL2-LRR1 -> CMG == MCM7+Ub -> MCM7+VCP+UFD1+NPL4", "KEGG_MEDICUS_REFERENCE_DNA_REPLICATION_LICENSING": "Pathway Definition from KEGG: ORC == CDC6 == CDT1 == MCM -> pre-RC+DDK == CDC45+TICRR+MTBP == CDK", "KEGG_MEDICUS_REFERENCE_DOUBLE_HOLLIDAY_JUNCTION_RESOLUTION": "Pathway Definition from KEGG: SLX == MUS81+EME1 == GEN1", "KEGG_MEDICUS_REFERENCE_DYNEIN_RECRUITMENT_TO_THE_KINETOCHORE": "Pathway Definition from KEGG: BUB1+CENPF == RZZ == (NDE1+NDEL1+LIS1),SPDL1,Dynactin == Dynein", "KEGG_MEDICUS_REFERENCE_DOUBLE_STRAND_BREAK_SIGNALING": "Pathway Definition from KEGG: MRN == ATM == H2AX -> MRN+ATM+MDC1+H2AX == RNF8+HERC2+UBE2V2+UBE2N -> MRN+ATM+RNF8+MDC1+H2AX == L3MBTL2 == RNF168+UBE2V2+UBE2N+HERC2 == PIAS4", "KEGG_MEDICUS_REFERENCE_DRD1_GNAS_AC_PKA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: DA -> DRD1 -> GNAS -> ADCY5 -> cAMP -> PKA -> CREB", "KEGG_MEDICUS_REFERENCE_EARLY_ENDOSOMAL_FUSION": "Pathway Definition from KEGG: (RABGEF1+RABEP1) -> RAB5 -> (PIK3C3+PIK3R4) -> PI3P -> EEA1", "KEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: E2 -> ESR1/2 -> SRC -> RAS -> RAF -> MEK -> ERK -> CREB", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_ACTIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> SRC -> CTTN -> NCK -> (WASL+WIPF) -> ARP2/3 -> (ACTB,ACTG1)", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> PLCG -> IP3 -> Ca2+ -> CALM == CN -> NFAT", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CAMK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> PLCG -> IP3 -> Ca2+ -> CALM == CAMK", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> GRB2 -> SOS -> RAS -> MEKK1 -> MKK4 -> JNK", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> GRB2 -> SOS -> RAS -> RALGDS -> RAL", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> GRB2 -> SOS -> RAS -> (RASSF1+RASSF5) -> STK4", "KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> (ERBB2+EGFR) -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> EGFR -> JAK1 -> STAT1/3/5", "KEGG_MEDICUS_REFERENCE_ELECTRON_TRANSFER_IN_COMPLEX_III": "Pathway Definition from KEGG: QH2 -- CxIII -> CytC", "KEGG_MEDICUS_REFERENCE_ELECTRON_TRANSFER_IN_COMPLEX_I": "Pathway Definition from KEGG: NADH -- CxI -> Q", "KEGG_MEDICUS_REFERENCE_ELECTRON_TRANSFER_IN_COMPLEX_IV": "Pathway Definition from KEGG: CytC -- CxIV -> H2O", "KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (EP,NE) -> ADRB2 -> GNAS -> ADCY -> cAMP -> PKA -> PLN", "KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EREG -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EREG -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_EXTRINSIC_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> FADD -> CASP8 -> (CASP3,CASP7)", "KEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING": "Pathway Definition from KEGG: ERK -> RSK", "KEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION": "Pathway Definition from KEGG: STAG1,STAG2 == PDS5+WAPL -> CDCA5,CTCF == STAG+PDS5+WAPL", "KEGG_MEDICUS_REFERENCE_FANCONI_ANEMIA_PATHWAY": "Pathway Definition from KEGG: FANCM+TOPBP1+MHF+FAAP24 -> ATR -> FAcore == FANCL+UBE2T -> FANCD2+FANCI+Ub", "KEGG_MEDICUS_REFERENCE_FASLG_RIPK1_3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FASLG -> FAS -> FADD -> (RIPK1+RIPK3)", "KEGG_MEDICUS_REFERENCE_FAS_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FASLG -> FAS -> (DAXX+ASK1) -> JNK", "KEGG_MEDICUS_REFERENCE_FE3_FERRITIN_TRANSPORT": "Pathway Definition from KEGG: ATG5/7 -> NCOA4 -- (Fe3++(FTH1+FTL))", "KEGG_MEDICUS_REFERENCE_FE_TF_TRANSPORT": "Pathway Definition from KEGG: Fe2+ -- CP -> Fe3+ -- (TF+TFR1) -> Fe3+(endosome) -- STEAP3 -> Fe2+ -- (DMT1,ZIP8/14) -> Fe2+", "KEGG_MEDICUS_REFERENCE_FGF_FGFR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FGF -> FGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_REFERENCE_FLCN_MTORC1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (SLC7A5+SLC3A2) -> FLCN -> (RRAGA+RRAGB+RRAGC+RRAGD) -> mTORC1", "KEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FGF -> FGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FLT3LG -> FLT3 -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FLT3LG -> FLT3 -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (CGA+FSHB) -> FSHR -> GNAS -> ADCY -> cAMP -> PKA", "KEGG_MEDICUS_REFERENCE_GATOR1_MTORC1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (NPRL2+NPRL3+DEPDC5) -| (RRAGA+RRAGB+RRAGC+RRAGD) -> mTORC1", "KEGG_MEDICUS_REFERENCE_GENE_SILENCING_BY_METHYLATION_OF_H3K27_AND_UBIQUITINATION_OF_H2AK119": "Pathway Definition from KEGG: PRC2.1 == (EPOP+ELOB+ELOC),(LCOR,LCORL+CTBP1,CTBP2) -- H3 -> PRC2.2 -- H3K27me3 == cPRC1 -- H2AK119+UB", "KEGG_MEDICUS_REFERENCE_GF_RTK_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GF -> RTK -> PI3K -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GF -> RTK -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GHRH -> GHRHR -> GNAS -> ADCY -> cAMP -> PKA -> CREB => POU1F1 => (GH1,GH2)", "KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GF -> RTK -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GH -> GHR -> JAK2 -> STAT5 => IGF1", "KEGG_MEDICUS_REFERENCE_GLUCONEOGENESIS": "Pathway Definition from KEGG: Pyruvate -- PC -> OA -- MDH1/2 >> PCK1/2 -> PEP", "KEGG_MEDICUS_REFERENCE_GLOBAL_GENOME_NER": "Pathway Definition from KEGG: (CRL4+DDB2) == (XPC+RAD23A,RAD23B+CETN2) -> (XPC+CETN2) == (ERCC3+ERCC2) == (GTF2H) == (CAK)", "KEGG_MEDICUS_REFERENCE_GLYCOGEN_BIOSYNTHESIS": "Pathway Definition from KEGG: Glc-1P -- UGP2 >> (GYG1/2+GYS1/2) >> GBE1 -> Glycogen", "KEGG_MEDICUS_REFERENCE_GLUTATHIONE_BIOSYNTHESIS": "Pathway Definition from KEGG: Cys+Glu -- (GCLC+GCLM) >> GSS -> GSH -- GPX -> GSSG", "KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION_AMYLASE_": "Pathway Definition from KEGG: Glycogen -- AMY >> (MGAM,GAA,GANC) -> Glc", "KEGG_MEDICUS_REFERENCE_GLYCOLYSIS": "Pathway Definition from KEGG: Glc-6P -- GPI >> PFK >> ALDO >> GAPDH >> PGK1/2 >> (PGAM,BPGM) >> ENO1/2/3/4 >> (PKLR,PKM) >> (LDH,LDHAL6) -> Lactate", "KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION": "Pathway Definition from KEGG: Glycogen -- (PYG+AGL) >> PGM1/2 -> Glc-6P -- G6PC1/2/3 -> Glc", "KEGG_MEDICUS_REFERENCE_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_LINKAGE_TETRASACCHARIDE": "Pathway Definition from KEGG: Protein-Ser -- XYLT1/2 >> B4GALT7 >> B3GALT6 >> B3GAT3 -> G00157", "KEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GNRH1/2 -> GNRHR -> (GNAQ,GNA11) -> PLCB -> (Ca2+,DAG) -> PKC -> RAF1 -> MEK -> ERK -> ELK1 => (LHB,CGA,FSHB)", "KEGG_MEDICUS_REFERENCE_GPCR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (GPCR+GNB+GNG) -> PI3Kgamma -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_GPI_ANCHOR_BIOSYNTHESIS": "Pathway Definition from KEGG: PI+UDP-GlcNAc -- (PIGA+PIGC+PIGH+PIGP+PIGQ+PIGY+DPM2) >> PIGL >> PIGW >> (PIGM+PIGX) >> PIGV >> PIGN >> PIGB >> (PIGO+PIGF) >> (PIGG+PIGF) >> (GPAA1+PIGK+PIGS+PIGT+PIGU) >> PGAP1 >> PGAP5 -> G13046", "KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY": "Pathway Definition from KEGG: HH -> PTCH // SMO -> (SMO+EVC) -> (SUFU+KIF7) // GLI => (GLI1,PTCH,HHIP)", "KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_HH_LIGAND_SECRETION": "Pathway Definition from KEGG: HHAT -> HH -- DISP1 >> SCUBE2 -> HH(extracellular)", "KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GPCR -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR": "Pathway Definition from KEGG: ((CDON,BOC),GAS1,LRP2) -> (HH+PTCH)", "KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS": "Pathway Definition from KEGG: G00157 -- EXTL2/3 >> EXT1/2 >> EXTL1/3 >> NDST >> GLCE >> HS6ST1 -> Heparan_sulfate", "KEGG_MEDICUS_REFERENCE_HEME_BIOSYNTHESIS": "Pathway Definition from KEGG: Gly -- ALAS1/2 >> ALAD >> HMBS >> UROS >> UROD >> CPOX >> PPOX >> FECH -> Heme", "KEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: HGF -> MET -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_DEGRADATION": "Pathway Definition from KEGG: HS -- IDS >> IDUA >> SGSH >> HGSNAT >> NAGLU >> GUSB >> GNS -> G02632", "KEGG_MEDICUS_REFERENCE_HIF_1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: HIF1A == ARNT => (SLC2A1,VEGFA,TGFB,PDGFB,TGFA)", "KEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: HGF -> MET -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_HOMOLOGOUS_RECOMBINATION": "Pathway Definition from KEGG: RPA == BRCA1+BARD1 == BRCA2+PALB2+DSS1 == RAD51 == BCDX2,CX3 -> RAD54 -> PCNA+RFC == POLD,POLE,POLK,POLH", "KEGG_MEDICUS_REFERENCE_HYDROLYSIS_OF_SPHINGOMYELIN": "Pathway Definition from KEGG: Sphingomyelin -- SMPD -> Ceramide -- ASAH -> Sphingosine", "KEGG_MEDICUS_REFERENCE_HOMOLOGOUS_RECOMBINATION_IN_ICLR": "Pathway Definition from KEGG: FANCD2+FANCI+Ub -> BRCA1+BARD1 == BRIP1 == BRCA2+PALB2+DSS1 == RPA == HROB+MCM8+MCM9", "KEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (EPO,GH,PRL,THPO,CSF3,LEP) -> (EPOR,GHR,PRLR,MPL,CSF3R,LEPR) -> JAK2 -> (STAT5A,STAT5B,STAT3)", "KEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ICOSLG -> ICOS -> PI3Kdelta -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_IFN_RIPK1_3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IFN -> IFNR -> JAKs -> STAT+IRF9 => (RIPK1+RIPK3)", "KEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -| EIF4EBP1", "KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGF2 -> IGF1R -> PI3K -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGF -> IGF1R -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_REFERENCE_IGG_FCGR_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGG -> FCGR -> CRK -> DOCK1 -> RAC", "KEGG_MEDICUS_REFERENCE_II_BLOOD_GROUP_ANTIGEN_BIOSYNTHESIS": "Pathway Definition from KEGG: nLc4Cer -- B3GNT2/3/4 >> B4GALT1/3/4 -> i_antigen -- GCNT2*I -> I_antigen", "KEGG_MEDICUS_REFERENCE_IL10_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (IL10,IL19,IL20,IL22,IL24,IL26) -> ((IL10RB+(IL10RA,IL20RA,IL22RA1)) -> (JAK1+TYK2) -> STAT3", "KEGG_MEDICUS_REFERENCE_IL12_23_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (IL12,IL23A) -> ((IL12RB1+IL12RB2),(IL12RB1+IL23R)) -> (JAK2+TYK2) -> (STAT3,STAT4)", "KEGG_MEDICUS_REFERENCE_IL1_IL1R_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IL1 -> IL1R -> MYD88 -> IRAK1/4 -> TRAF6 -> TAB1/2/3 -> TAK1 -> MKK4/7 -> JNK -> AP1", "KEGG_MEDICUS_REFERENCE_IL1_IL1R_P38_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IL1 -> IL1R -> MYD88 -> IRAK1/4 -> TRAF6 -> TAB1/2/3 -> TAK1 -> MKK3/6 -> MAPK14 -> MK2 -| TTP", "KEGG_MEDICUS_REFERENCE_IL6_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (IL6,IL11,IL13,IL27,IL31,OSM,LIF,CNTF,CTF1,CLCF1) -> ((IL6ST+(IL6R,IL11RA,IL27RA,OSMR,LIFR,CNTFR)),(IL4R+IL13RA),(IL31RA+OSMR)) -> (JAK1+JAK2+TYK2) -> (STAT1,STAT3,STAT6)", "KEGG_MEDICUS_REFERENCE_IL2_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (IL2,IL4,IL7,IL9,IL15,IL21,TSLP) -> ((IL2RG+IL2RB+(IL2RA,IL15RA),(IL2RG+(IL4R,IL7R,IL9R,IL21R),(IL7R+CRLF2)) -> (JAK1+JAK3) -> (STAT1,STAT3,STAT5,STAT6)", "KEGG_MEDICUS_REFERENCE_INACTIVATION_OF_CONDENSIN_I": "Pathway Definition from KEGG: CK2 -| SMC4,NCAPD2,NCAPG,NCAPH", "KEGG_MEDICUS_REFERENCE_INTRINSIC_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: (PMAIP1,BBC3,BAD,BCL2L11) -| (BCL2,BCL2L1) -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)", "KEGG_MEDICUS_REFERENCE_IRE1A_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ERN1 -> TRAF2 -> MAP3K5 -> MAP2K7 -> JNK", "KEGG_MEDICUS_REFERENCE_ISOLEUCINE_DEGRADATION": "Pathway Definition from KEGG: 2-MB-CoA -- (ACADS,ACADSB,ACADM) >> (ECHS1,HADHA) >> (HSD17B10,HADH) >> (ACAA1/2,HADHB) -> Propanoyl-CoA", "KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> (SRC,PTK2) -> PXN -> (GIT2+ARHGEF7) -> CDC42", "KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> SRC -> ARHGAP35 -| RHOA", "KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> PTK2 -> ARHGEF28 -> RHOA", "KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> (SRC,PTK2) -> (PXN,CRK+BCAR1) -> (DOCK1+ELMO1) -> RAC", "KEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> (PTK2+PXN+ILK) -> (TLN+ACTN1/4+VCN) -> (ACTB,ACTG1)", "KEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> RHOG -> (DOCK1+ELMO) -> RAC", "KEGG_MEDICUS_REFERENCE_KEAP1_NRF2_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (O2-,HO2,H2O2,OH,ACRL,4HNE,NO) -| KEAP1 -| NRF2 => (HMOX1,NQO1,GST,TXNRD1)", "KEGG_MEDICUS_REFERENCE_KINETOCHORE_FIBER_ORGANIZATION": "Pathway Definition from KEGG: AURKA -- (TACC3+ch-TOG) -> (TACC3+ch-TOG) == microtubule -> clathrin == (TACC3+ch-TOG) == microtubule", "KEGG_MEDICUS_REFERENCE_KERATAN_SULFATE_DEGRADATION": "Pathway Definition from KEGG: KS -- GALNS >> GLB1 >> GNS >> HEXA/B -> G01391", "KEGG_MEDICUS_REFERENCE_KINETOCHORE_MICROTUBULE_ATTACHMENT": "Pathway Definition from KEGG: (CENPF,BUBR1) == CENPE == microtubule", "KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: KISS1 -> KISS1R -> (GNAQ,GNA11) -> PLCB -> (Ca2+,DAG) -> PKC", "KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: KITLG -> KIT -> PI3K -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COAGULATION_CASCADE_PROTHROMBIN_TO_THROMBIN": "Pathway Definition from KEGG: F2 -- ((MBL2,COLEC10/11,FCN)+MASP2) -> F2a", "KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COAGULATION_CASCADE_FIBRINOGEN_TO_FIBRIN": "Pathway Definition from KEGG: FG -- (F2a,((MBL2,COLEC10/11,FCN)+MASP1)) -> Fibrin", "KEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: KITLG -> KIT -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_LEWIS_X_ANTIGEN_BIOSYNTHESIS": "Pathway Definition from KEGG: nLc4Cer -- FUT3/4/5/6/9 -> Lex", "KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION": "Pathway Definition from KEGG: [C4,C2] -- ((MBL2,COLEC10/11,FCN)+MASP1/2) -> [C4b,C2a] -> (C4b+C2a)", "KEGG_MEDICUS_REFERENCE_LESION_BYPASS_BY_TLS_AND_DSB_FORMATION": "Pathway Definition from KEGG: FANCD2+FANCI+Ub -> FAN1 == SLX+MUS81+EME1 == ERCC4+ERCC1+SNM1A -> REV1,REV3L,REV7", "KEGG_MEDICUS_REFERENCE_LEUCINE_DEGRADATION": "Pathway Definition from KEGG: IV-CoA -- (IVD,ACADM) >> MCCC1/2 >> AUH >> (HMGCL,HMGCLL1) -> AcCoA", "KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (LHB+CGA) -> LHCGR -> GNAS -> ADCY -> cAMP -> PKA", "KEGG_MEDICUS_REFERENCE_LIGHT_HVEM_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TNFSF14 -> TNFRSF14 -> TRAF2/5 -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_REFERENCE_LOADING_OF_THE_SMC5_SMC6_COMPLEX": "Pathway Definition from KEGG: RNF168 -> RAD18+UBB == SLF1+SLF2 == SMC5-SMC6", "KEGG_MEDICUS_REFERENCE_LONG_PATCH_BER": "Pathway Definition from KEGG: POLB == (POLD,POLE) == PCNA == RFC -> PCNA+FEN1 -> PCNA+LIG1", "KEGG_MEDICUS_REFERENCE_LPA_GNA12_13_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: LPA -> LPAR -> GNA12/13 -> (ARHGEF12,ARHGEF1,ARHGEF11) -> RHOA -> ROCK1/2", "KEGG_MEDICUS_REFERENCE_LPAR_GNB_G_RHO_SIGNALING_PATHWAY": "Pathway Definition from KEGG: LPA -> LPAR -> GNB/G -> RHOA", "KEGG_MEDICUS_REFERENCE_LYSOSOMAL_CA2_RELEASE": "Pathway Definition from KEGG: PI(3.5)P2 -> MCOLN1 -> Ca2+(cyto) -> CALM == CN -> TFEB", "KEGG_MEDICUS_REFERENCE_LPA_GNAQ_11_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: LPA -> LPAR -> (GNAQ,GNA11) -> ARHGEF12 -> RHOA", "KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: ACh -> mAChR -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS", "KEGG_MEDICUS_REFERENCE_MANNOSE_TYPE_O_GLYCAN_BIOSYNTHESIS_FKTN_TO_LARGE": "Pathway Definition from KEGG: G13092+CDP-Rib-ol -- FKTN >> FKRP >> TMEM5 >> B4GAT1 >> LARGE1/2 -> G13099", "KEGG_MEDICUS_REFERENCE_MAGI_PTEN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: MAGI -> PTEN -| PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_MDA5_IRF7_3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: RNA -> MDA5 -> MAVS -> TRAF3 -> (TANK+NAP1+SINTBAD) -> (TBK1+IKBKE) -> (IRF7,IRF3) => (IFNA,IFNB1)", "KEGG_MEDICUS_REFERENCE_MANNOSE_TYPE_O_GLYCAN_BIOSYNTHESIS_POMT_TO_POMK": "Pathway Definition from KEGG: Ser/Thr+Man-P-Dol -- POMT1/2 >> POMGNT2 >> B3GALNT2 >> POMK -> G13092", "KEGG_MEDICUS_REFERENCE_MDM2_P21_CELL_CYCLE_G1_S_N00066": "Pathway Definition from KEGG: CDKN2A -| MDM2 -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F", "KEGG_MEDICUS_REFERENCE_MDM2_P21_CELL_CYCLE_G1_S_N00536": "Pathway Definition from KEGG: CDKN2A -| MDM2 -| TP53 => CDKN1A -| (CCNE+CDK2) -> RB1 // E2F", "KEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: P4 -> mPR -> PI3K -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_METHIONINE_DEGRADATION": "Pathway Definition from KEGG: Met -- MAT >> (GNMT,DNMT) >> AHCY -> Hcy+Adenosine", "KEGG_MEDICUS_REFERENCE_MEVALONATE_PATHWAY": "Pathway Definition from KEGG: Acetyl-CoA -- ACAT >> HMGCS >> HMGCR >> MVK >> PMVK >> MVD >> IDI >> (FDPS,GGPS1) -> Farnesyl-PP", "KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Glutamate -> GRM1 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -> PKC -| TRPC3 -> Ca2+", "KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: Glutamate -> GRM5 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)", "KEGG_MEDICUS_REFERENCE_MICROTUBULE_DEPOLYMERIZATION_AT_THE_MINUS_ENDS": "Pathway Definition from KEGG: PLK1 -> KIF2A == DDA3 == microtubule", "KEGG_MEDICUS_REFERENCE_MICROTUBULE_DEPOLYMERIZATION": "Pathway Definition from KEGG: (AURKA,AURKB) -| (MCAK+KIF18B) == EB1,EB3 == microtubule", "KEGG_MEDICUS_REFERENCE_MICROTUBULE_RHOA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (TUBA+TUBB) -| ARHGEF2 -> RHOA -> ROCK1/2", "KEGG_MEDICUS_REFERENCE_MICROTUBULE_NUCLEATION": "Pathway Definition from KEGG: CDK5RAP2 == gamma-TuRC+TPX2 == ch-TOG == microtubule", "KEGG_MEDICUS_REFERENCE_MISMATCH_REPAIR": "Pathway Definition from KEGG: (MSH2+MSH6,MSH3) == (MLH1+PMS2,PMS1,MLH3) == PCNA == RFC -> RPA == EXO1 -> POLD,POLE -> LIG1", "KEGG_MEDICUS_REFERENCE_MITOCHONDRIAL_COMPLEX_UCP1_IN_THERMOGENESIS": "Pathway Definition from KEGG: CxI == CxII == CxIII == CxIV == ATPase -> UCP1", "KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: MLK -> MKK4/7 -> JNK", "KEGG_MEDICUS_REFERENCE_MODIFYING_OF_CONDENSIN_II_SUBUNITS": "Pathway Definition from KEGG: PLK1,AURKB,CDK1 -- NCAPD3,NCAPG2,NCAPH2", "KEGG_MEDICUS_REFERENCE_MODIFYING_OF_CONDENSIN_I_SUBUNITS": "Pathway Definition from KEGG: AURKB,CDK1 -- NCAPD2,NCAPG,NCAPH", "KEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: MSTN -> (ACVR2B+(ACVR1B,TGFBR1)) -> (SMAD1,SMAD5,SMAD9) == SMAD4", "KEGG_MEDICUS_REFERENCE_NAD_BIOSYNTHESIS": "Pathway Definition from KEGG: Trp -- (TDO2,IDO1/2) >> AFMID -> Kyn -- KMO >> KYNU >> HAAO >> QPRT >> NMNAT >> NADSYN1 -> NAD+", "KEGG_MEDICUS_REFERENCE_NALP12_INFLAMMASOME_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (NLRP12+PYCARD) -> CASP1 -> (IL1B,IL18)", "KEGG_MEDICUS_REFERENCE_NLRP1_INFLAMMASOME_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (NLRP1+PYCARD) -> CASP1 -> (IL1B,IL18)", "KEGG_MEDICUS_REFERENCE_NLRP3_INFLAMMASOME_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (NLRP3+PYCARD) -> CASP1 -> (IL1B,IL18,IL33)", "KEGG_MEDICUS_REFERENCE_NLRC4_INFLAMMASOME_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (NLRC4+PYCARD) -> CASP1 -> (IL1B,IL18)", "KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY": "Pathway Definition from KEGG: NODAL -> ((ACVR2A,ACVR2B)+(ACVR1B,ACVR1C)) -> (SMAD2,SMAD3) == SMAD4", "KEGG_MEDICUS_REFERENCE_NOD_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (NOD1,NOD2) -> RIPK2 -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_REFERENCE_NON_CANONICAL_INFLAMMASOME_SIGNALING_PATHWAY": "Pathway Definition from KEGG: LPS -> CASP4/5 -> (NLRP3+PYCARD+CASP1) -> (IL1B,IL18)", "KEGG_MEDICUS_REFERENCE_NON_HOMOLOGOUS_END_JOINING": "Pathway Definition from KEGG: TP53BP1+RIF1+PAXIP1 -> Ku == DNAPKC -> DNAPK+ARTEMIS -> DNAPK+POLX -> DNAPK == LIG4+XRCC4+XLF", "KEGG_MEDICUS_REFERENCE_NOTCH_LIGAND_UBIQUITYLATION": "Pathway Definition from KEGG: (MIB,NEUR) -> (DLL,JAG)", "KEGG_MEDICUS_REFERENCE_NOTCH_MESP2_SIGNALING": "Pathway Definition from KEGG: (NICD+RBPJ+TBX6) => MESP2 => (RIPPLY2,LFNG,EPHA4)", "KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION": "Pathway Definition from KEGG: NOTCH -- ADAM17 >> (PSEN+PSENEN+NCSTN+APH1) -> NICD", "KEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: NRG -> ERBB4 -> PI3K -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (DLL,JAG) -> NOTCH -> (NICD+RBPJ) => (HES1,HEY1)", "KEGG_MEDICUS_REFERENCE_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: E2 -> ((ESR1/2)+(NCOA1/2/3)) => (BCL2,EBAG9,KRT19,CTSD,TFF1,PGR)", "KEGG_MEDICUS_REFERENCE_N_GLYCAN_BIOSYNTHESIS": "Pathway Definition from KEGG: G00009 -- MOGS >> GANAB >> MAN1 >> MGAT1 >> MAN2 >> MGAT2 >> FUT8 >> B4GALT >> ST6GAL -> G00018", "KEGG_MEDICUS_REFERENCE_NUCLEAR_INITIATED_PROGESTERONE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: P4 -> PGR => (CCND1,TNFSF11,WNT4,CXCL12)", "KEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA": "Pathway Definition from KEGG: (mRNA(nuclear)+CBP+ALY+SR+TAP+p15) -- (NPC+GLE1+DDX19B) -> (mRNA(cytoplasmic),CBP,ALY,SR,TAP,p15)", "KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG7_TO_ALG11": "Pathway Definition from KEGG: P-Dol -- ALG7 >> (ALG13+ALG14) >> ALG1 >> ALG2 >> ALG11 -> G00006", "KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST": "Pathway Definition from KEGG: G00007+Glc-P-Dol -- ALG6 >> ALG8 >> ALG10 >> (STT+OST) -> G00009", "KEGG_MEDICUS_REFERENCE_OKAZAKI_FRAGMENT_MATURATION": "Pathway Definition from KEGG: POLD+PCNA -> DNA2 == RNaseH2 == FEN1 -> LIG1", "KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_GLC_6P_TO_MAN_P_DOL": "Pathway Definition from KEGG: Glc-6P -- GPI >> MPI >> PMM1/2 >> GMPP >> DPM1/2/3 -> Man-P-Dol", "KEGG_MEDICUS_REFERENCE_ORGANIZATION_OF_THE_OUTER_KINETOCHORE": "Pathway Definition from KEGG: CPC == CENPC == MIS12C+KNL1C+CENP-TWSX -> CPC+CENPC+MIS12C+KNLC == CENP-TWSX == NDC80C", "KEGG_MEDICUS_REFERENCE_ORGANIZATION_OF_THE_INNER_KINETOCHORE": "Pathway Definition from KEGG: CENPA == CENPC == CENP-LN+CENP-HIKM+CENP-OPQUR == CENP-TWSX", "KEGG_MEDICUS_REFERENCE_P15_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: (MYC+MAX) -| ZBTB17 => CDKN2B -| (CCND+CDK4/6) -> RB1 // E2F", "KEGG_MEDICUS_REFERENCE_P16_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: CDKN2A -| (CCND+CDK4/6) -> RB1 // E2F", "KEGG_MEDICUS_REFERENCE_ORIGIN_UNWINDING_AND_ELONGATION": "Pathway Definition from KEGG: CMG+POLE+MCM10 == POLA+PRIM == RPA -> CMG+MCM10+CTF4+POLA+POLE == RFC+PCNA", "KEGG_MEDICUS_REFERENCE_P27_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: (SCF+SKP2) -| CDKN1B -| ((CCNA,CCNE)+CDK2) -> RB1 // E2F", "KEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: P4 -> (PGR+SRC) -> PI3K -> PIP3 -> AKT", "KEGG_MEDICUS_REFERENCE_P300_P21_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: (ATM,ATR) -> TADA3 -> EP300 -> TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F", "KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PDGF -> PDGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: P4 -> (PGR+SRC) -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PDGF -> PDGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PLCG_CAMK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PDGF -> PDGFR -> PLCG -> IP3 -> Ca2+ -> CALM == CAMK", "KEGG_MEDICUS_REFERENCE_PDL_PD1_SHP_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (PDL1,PDL2) -> PDCD1 -> SHP1/2 -| PI3Kdelta", "KEGG_MEDICUS_REFERENCE_PKA_HOLOENZYME": "Pathway Definition from KEGG: PRKAR -| PKA", "KEGG_MEDICUS_REFERENCE_PINK_PARKIN_MEDIATED_AUTOPHAGOSOME_FORMATION": "Pathway Definition from KEGG: PINK1 -> PRKN -> (CISD1,CISD2,FAF2,FKBP8,TOMM70,HK1) == (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) == LC3", "KEGG_MEDICUS_REFERENCE_PKR_EIF2ALPHA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EIF2AK2 -> EIF2S1 -| EIF2B", "KEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA": "Pathway Definition from KEGG: PLG -> FBN1 == LTBP1/3/4 // TGFB", "KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PP2A -| AKT", "KEGG_MEDICUS_REFERENCE_PRE_IC_FORMATION": "Pathway Definition from KEGG: TOPBP1+RECQL4 == POLE == GINS -> ORC+CDC6+CDT1 == CDC45+MCM+GINS == POLE+TOPBP1+TICRR+MTBP+RECQL4", "KEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PRL -> PRLR -> JAK2 -> STAT5", "KEGG_MEDICUS_REFERENCE_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PROK1/2 -> PROKR1/2 -> GNAI -> ERK", "KEGG_MEDICUS_REFERENCE_PRNP_PI3K_NOX2_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PRNP -> CAV -> FYN -> PI3K -> PRKCD -> NOX2 -> ERK -> CREB => EGR1", "KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PTH -> PTH1R -> GNAS -> ADCY -> cAMP -> PKA", "KEGG_MEDICUS_REFERENCE_PURINE_SALVAGE_PATHWAY_ADENINE_TO_AMP": "Pathway Definition from KEGG: AMP -- NT >> (PNP,LACC1) -> Adenine -- APRT -> AMP", "KEGG_MEDICUS_REFERENCE_PURINE_SALVAGE_PATHWAY_HYPOXANTHINE_GUANINE_TO_IMP_GMP": "Pathway Definition from KEGG: [IMP,GMP] -- NT >> (PNP,LACC1) -> [Hypoxanthine,Guanine] -- HPRT1 -> [IMP,GMP]", "KEGG_MEDICUS_REFERENCE_PROMOTION_OF_MICROTUBULE_GROWTH": "Pathway Definition from KEGG: (CLIP1,CLIP2)+(CLASP1,CLASP2) == EB1 == microtubule", "KEGG_MEDICUS_REFERENCE_PYRIN_INFLAMMASOME_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (MEFV+PYCARD) -> CASP1 -> (IL1B,IL18)", "KEGG_MEDICUS_REFERENCE_RAD51_DSDNA_DESTABILIZATION": "Pathway Definition from KEGG: RFWD3 -| RPA,RAD51 == BCDX2+HELQ", "KEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (RAC1,CDC42) -> PAK1 -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_RAB7_REGULATED_MICROTUBULE_MINUS_END_DIRECTED_TRANSPORT": "Pathway Definition from KEGG: RAB7 == RILP == OSBPL1A == (DYNC+DYNL+DCTN+ACTR1+ACTR10) == (TUBA+TUBB)", "KEGG_MEDICUS_REFERENCE_RECRUITMENT_AND_FORMATION_OF_THE_MCC": "Pathway Definition from KEGG: AURKB -- NDC80 == MPS1 -- KNL1 == (BUB1+BUB3+BUBR1) == (MAD1+MAD2) -> KNL1+MCC", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR": "Pathway Definition from KEGG: CFHR -| CFH", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_EXTRINSIC_APOPTOTIC_PATHWAY_XIAP": "Pathway Definition from KEGG: XIAP -| (RIPK1+RIPK3+FADD+CASP8)", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_MAC_INHIBITION": "Pathway Definition from KEGG: (CD59,CLU,VTN) -| (C5b+C6+C7+C8+C9)", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_FIBRINOLYTIC_SYSTEM_PAI": "Pathway Definition from KEGG: PAI -| (PLAU,PLAT)", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_FIBRINOLYTIC_SYSTEM_C1INH": "Pathway Definition from KEGG: SERPING1 -| (F11a,F12a,Kallikrein,Plasmin,PLAU,C1R,C1S,MASP1/2)", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE": "Pathway Definition from KEGG: (MRAS+SHOC2+PP1) -> RAF", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PATHWAY_ADAPTOR_PROTEINS": "Pathway Definition from KEGG: (PTPN11,SHC,GAB,GRB2) -> SOS", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RASGAP": "Pathway Definition from KEGG: RasGAP -| RAS", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PTP": "Pathway Definition from KEGG: (PTP,MKP) -| (ERK,JNK,MAPK14)", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_SPRED_AND_NF1": "Pathway Definition from KEGG: (SPRED+NF1) -| RAS", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RAS_UBIQUITINATION_BY_CUL3_COMPLEX": "Pathway Definition from KEGG: (LZTR1+CUL3) -| (RAS,RIT1)", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_NLRP3_INFLAMMASOME_SIGNALING_PATHWAY_NLRP3_INHIBITION": "Pathway Definition from KEGG: (CARD8,GPSM3,IRGM,NO) -| (NLRP3+PYCARD)", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL": "Pathway Definition from KEGG: CBL -| RTK", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_SERCA": "Pathway Definition from KEGG: (PLN,SLN,MLN,ELN,ALN) -| ATP2A", "KEGG_MEDICUS_REFERENCE_REGULATION_OF_TNF_NFKB_SIGNALING_PATHWAY_LUBAC_MEDIATED_LINEAR_UBIQUITINATION": "Pathway Definition from KEGG: (RBCK1+RNF31+SHARPIN) -> (RIPK1,IKBKG,TNFRSF1A)", "KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: RELN -> VLDLR == DAB1 -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -> S6K", "KEGG_MEDICUS_REFERENCE_RIG_I_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: RNA -> RIGI -> MAVS -> IKK -> NFKBIA -> NFKB => (IFNA,IFNB1)", "KEGG_MEDICUS_REFERENCE_RIG_I_IRF7_3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: RNA -> RIGI -> MAVS -> TRAF3 -> (TANK+NAP1+SINTBAD) -> (TBK1+IKBKE) -> (IRF7,IRF3) => (IFNA,IFNB1)", "KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: (DCTN+DNAH+DNAI+DNALI1+DNAL) == (TUBA+TUBB)", "KEGG_MEDICUS_REFERENCE_RORA_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: (RORA+KAT5) => (ITPR1,SLC1A6,GRM1)", "KEGG_MEDICUS_REFERENCE_SIALYL_LEWIS_X_ANTIGEN_BIOSYNTHESIS": "Pathway Definition from KEGG: nLc4Cer -- ST3GAL6 -> snLc4Cer -- FUT3/4/5/6/7 -> SLex", "KEGG_MEDICUS_REFERENCE_SEROTONIN_METABOLISM": "Pathway Definition from KEGG: Trp -- TPH1/2 >> DDC -> Serotonin -- MAO -> 5-HIAL", "KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GF -> RTK -> PLCG -> IP3 -> ITPR -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_SKELETAL_TYPE_VGCC_RYR_SIGNALING": "Pathway Definition from KEGG: CAV1.1 -> (RYR1+TRDN+JCN+CASQ) -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_SPINDLE_ASSEMBLY_CHECKPOINT_SIGNALING": "Pathway Definition from KEGG: MAD1L1 -> (MAD2L1/2+BUB1B+BUB3) -| (ANAPC+CDC20) -| PTTG -| ESPL1", "KEGG_MEDICUS_REFERENCE_STRAD_STK11_TSC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (STRADA+STRADB+STK11) -> (PRKAA1+PPKAA2) -> (TSC1+TSC2+TBC1D7)", "KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE": "Pathway Definition from KEGG: Progesterone -- CYP17A1 >> CYP21A2 >> CYP11B1/2 -> Cortisol -- HSD11B2 -> Cortisone", "KEGG_MEDICUS_REFERENCE_TBK1_MEDIATED_AUTOPHAGOSOME_FORMATION": "Pathway Definition from KEGG: TBK1 -> (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) == LC3-II", "KEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TAC3 -> TACR3 -> GNAQ -> PLCB -> (Ca2+,DAG) -> PKC", "KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (TCR+CD3+CD4) -> (LCK,FYN,ZAP70) -> (SLP76+GADS+LAT+VAV) -> PLCG -> IP3 -> ITPR -> Ca2+(cyto)", "KEGG_MEDICUS_REFERENCE_TELOMERASE_RNA_MATURATION": "Pathway Definition from KEGG: TERC+TGS1 -> TERC+PAPD5 -> TERC+PARN+ZCCHC8", "KEGG_MEDICUS_REFERENCE_TELOMERE_ELONGATION": "Pathway Definition from KEGG: RTEL1+RAP1+TRF2+TIN2+TRF1+POT1+ACD == telomerase -> Shelterin == CTC1+STN1+TEN1", "KEGG_MEDICUS_REFERENCE_TESTOSTERONE_BIOSYNTHESIS": "Pathway Definition from KEGG: Pregnenolone -- CYP17A1 >> HSD3B1/2 -> Androstenedione -- (AKR1C3,HSD17B) -> T -- SRD5A -> DHT", "KEGG_MEDICUS_REFERENCE_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES": "Pathway Definition from KEGG: ARL8B == PLEKHM1 == RAB7 == HOPS", "KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TGFA -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PLCG_PKC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TGFA -> EGFR -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> ELK1", "KEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TGFA -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_REFERENCE_THYROID_HORMONE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (SLC16A10,SLC16A2) -> T3 -> (THRB,THRA) == RXR => (MYH6,ATP2A2)", "KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TGFB -> (TGFBR2+TGFBR1) -> (SMAD2,SMAD3) == SMAD4", "KEGG_MEDICUS_REFERENCE_TLR1_2_4_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (TLR1,TLR2,TLR4) -> (TIRAP+MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (TNF,IL6,IL12A,IL12B)", "KEGG_MEDICUS_REFERENCE_TIGHT_JUNCTION_ACTIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (OCLN,CLDN) == TJP1 == CTTN == ARP2/3 == (ACTB,ACTG1)", "KEGG_MEDICUS_REFERENCE_TLR2_4_MAPK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (TLR2,TLR4) -> (TIRAP+MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> (MEK,MKK3/6,MKK4/7) -> (ERK,p38,JNK) -> AP1", "KEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TLR3 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> IRF3 -> (CREBBP,EP300) => IFNB1", "KEGG_MEDICUS_REFERENCE_TLR3_IRF7_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TLR3 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> IRF7 => IFNA", "KEGG_MEDICUS_REFERENCE_TLR3_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TLR3 -> TICAM1 -> TRAF6 -> TAK1 -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_REFERENCE_TLR5_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TLR5 -> (MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (TNF,IL6,IL12A,IL12B)", "KEGG_MEDICUS_REFERENCE_TLR4_IRF3_7_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TLR4 -> TICAM2 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> (IRF3,IRF7) => IFNB1", "KEGG_MEDICUS_REFERENCE_TLR7_9_IRF7_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (TLR7,TLR9) -> MYD88 -> (IRAK4+IRAK1) -> IRF7 => (IFNA,IFNB1)", "KEGG_MEDICUS_REFERENCE_TLR7_8_9_IRF5_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (TLR7+TLR8+TLR9) -> MYD88 -> (IRAK4+IRAK1) -> TRAF6 -> IRF5 => (IFNA,IFNB1)", "KEGG_MEDICUS_REFERENCE_TNF_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAK1+TAB1/2) -> MKK4/7 -> JNK -> AP1", "KEGG_MEDICUS_REFERENCE_TNFSF10_RIPK1_3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TNFSF10 -> TNFRSF10 -> (RIPK1+RIPK3)", "KEGG_MEDICUS_REFERENCE_TNF_NFKB_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB", "KEGG_MEDICUS_REFERENCE_TRAIP_DEPENDENT_REPLISOME_DISASSEMBLY": "Pathway Definition from KEGG: CMG+TRAIP -> CMG == MCM7+Ub -> MCM7+VCP+UFD1+NPL4", "KEGG_MEDICUS_REFERENCE_TNF_P38_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAK1+TAB1/2) -> MKK3/6 -> MAPK14 -> MSK1/2 -> CREB", "KEGG_MEDICUS_REFERENCE_TNF_RIPK1_3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TNF -> TNFRSF1A -> (TRAF2/5+TRADD+RIPK1+RIPK3)", "KEGG_MEDICUS_REFERENCE_TRANSCRIPTIONAL_ACTIVATION_BY_ACETYLATION_OF_H3K27": "Pathway Definition from KEGG: PRC1.3,PRC1.5 == TEX10+EP300 -- H3 -> H3K27ac", "KEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM": "Pathway Definition from KEGG: Glutamate -> NMDAR -> Ca2+", "KEGG_MEDICUS_REFERENCE_TRANSCRIPTION_COUPLED_NER": "Pathway Definition from KEGG: (POLR2+UVSSA) == (ERCC6+ERCC8+CRL4) -> (POLR2+UVSSA+ERCC6+ERCC8+CRL4) == (ERCC3+ERCC2) == (GTF2H) == (CAK)", "KEGG_MEDICUS_REFERENCE_TRANSLATION_INITIATION": "Pathway Definition from KEGG: 40S == mRNA == 60S", "KEGG_MEDICUS_REFERENCE_TRAPPI_RAB1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TRAPPI -> RAB1", "KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TRH -> TRHR -> GNAQ/11 -> PLCB -> (Ca2+,DAG) -> PKC -> TSHB", "KEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TSHB -> TSHR -> GNAQ -> PLCB -> (Ca2+,DAG) -> PKC -> DUOX2 -> H2O2 -> TG", "KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TSHB -> TSHR -> GNAS -> ADCY -> cAMP -> PKA -> (TTF1,TTF2,PAX8,CREB) => TG", "KEGG_MEDICUS_REFERENCE_TSC1_2_MTORC1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (TSC1+TSC2+TBC1D7) -| RHEB -> mTORC1", "KEGG_MEDICUS_REFERENCE_TYPE_II_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IFNG -> (IFNGR1,IFNGR2) -> (JAK1+JAK2) -> (STAT1,STAT3) => (IL27,IFNA,IFNG)", "KEGG_MEDICUS_REFERENCE_TYPE_I_IFN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (IFNA,IFNB1) -> (IFNAR1+IFNAR2) -> (JAK1,TYK2) -> (STAT1+STAT2+IRF9) => (IRF7,EIF2AK2)", "KEGG_MEDICUS_REFERENCE_TYPE_I_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (IFNA,IFNB1,IFNW1,IFNK,IFNE) -> (IFNAR1+IFNAR2) -> (JAK1+TYK2) -> (STAT1+STAT2) == IRF9", "KEGG_MEDICUS_REFERENCE_TYROSINE_DEGRADATION": "Pathway Definition from KEGG: Tyr -- TAT >> HPD >> HGD >> GSTZ1 >> FAH -> Fumarate+Acetoacetate", "KEGG_MEDICUS_REFERENCE_UCHL1_MEDIATED_HYDROLYSIS": "Pathway Definition from KEGG: UB(chain) -- UCHL1 -> UB(free)", "KEGG_MEDICUS_REFERENCE_UREA_CYCLE": "Pathway Definition from KEGG: NH3 -- CPS1 >> OTC >> ASS1 >> ASL >> ARG1/2 -> Urea+Ornithine", "KEGG_MEDICUS_REFERENCE_VALINE_DEGRADATION": "Pathway Definition from KEGG: IB-CoA -- (ACADS,ACAD8,ACADM) >> (ECHS1,HADHA) >> HIBCH >> HIBADH >> ALDH6A1 -> Propanoyl-CoA", "KEGG_MEDICUS_REFERENCE_V_D_J_RECOMBINATION": "Pathway Definition from KEGG: RAG1+RAG2 -> Ku == DNAPKC -> DNAPK+ARTEMIS -> DNAPK+POLX -> DNAPK == LIG4+XRCC4+XLF", "KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: Ca2+(extracellular) -- VGCC -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)", "KEGG_MEDICUS_REFERENCE_WEE1_CELL_CYCLE_G2_M": "Pathway Definition from KEGG: ATR -> CHEK1 -> WEE1 -| (CCNB+CDK1)", "KEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY": "Pathway Definition from KEGG: WNT5A -> (FZD,(ROR1,ROR2)) -> DVL", "KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO": "Pathway Definition from KEGG: (RSPO+LGR4/5/6)) -| (ZNRF3,RNF43) -| FZD", "KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4": "Pathway Definition from KEGG: (SOST+LRP4) -| (FZD+LRP5/6)", "KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION": "Pathway Definition from KEGG: PORCN -> WNT", "KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR": "Pathway Definition from KEGG: (SFRP,WIF1,CER1,NOTUM,TRABD2) -| WNT", "KEGG_MEDICUS_VARIANT_AML1_ETO_FUSION_TO_PU.1_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: AML1-ETO -| SPI1 => (CD14,ITGAM,FCGR1A)", "KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: WNT -> (FZD+LRP5/6) -> (DVL+FRAT) -| (GSK3B+AXIN+APC) -| CTNNB1 -> TCF/LEF => (MYC,CCND1)", "KEGG_MEDICUS_VARIANT_AMPLIFIED_CCNE_TO_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: (CCNE*+CDK2) -> RB1 // E2F", "KEGG_MEDICUS_VARIANT_AMPLIFIED_CDK4_TO_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: (CCND+CDK4*) -> RB1 // E2F", "KEGG_MEDICUS_VARIANT_AMPLIFIED_CCND1_TO_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: (CCND1*+CDK4) -> RB1 // E2F", "KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGFR* -> PI3K -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGFR* -> PLCG -> IP3 -> Ca2+ -> CALM == CAMK", "KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FGFR* -> PI3K -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_AMPLIFIED_MDM2_TO_P21_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: MDM2* -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F", "KEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: MET* -> GAB1 -> PI3K -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_VARIANT_AMPLIFIED_MYCN_TO_TRANSCRIPTIONAL_ACTIVATION": "Pathway Definition from KEGG: MYCN* == MAX => (MDM2,PTK2,TP53,BMI1)", "KEGG_MEDICUS_VARIANT_AMPLIFIED_MYCN_TO_TRANSCRIPTIONAL_REPRESSION": "Pathway Definition from KEGG: MYCN* == MAX == (SP1+ZBTB17) => (NTRK1,NGFR)", "KEGG_MEDICUS_VARIANT_AMPLIFIED_MYC_TO_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: (MYC*+MAX) => (CCND+CDK4/6) -> RB1 // E2F", "KEGG_MEDICUS_VARIANT_AMPLIFIED_MYC_TO_P27_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: (MYC*+MAX) => CKS1B -> (SCF+SKP2) -| CDKN1B -| (CCNE+CDK2) -> RB1 // E2F", "KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PDGFR* -> PI3K -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PDGFR* -> PLCG -> IP3 -> Ca2+ -> CALM == CAMK", "KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PDGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_AMPLIFIED_REL_TO_TRANSCRIPTION": "Pathway Definition from KEGG: REL* => (CCND2,BCL2A1,BIRC3,TRAF1,BCL2L1,CD86,CD40)", "KEGG_MEDICUS_VARIANT_BCL2_OVEREXPRESSION_TO_INTRINSIC_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: BCL2* -| BAX -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)", "KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: BCR-ABL -> (CRKL+CBL+CRK) -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: BCR-ABL -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_CDX2_OVEREXPRESSION_TO_TRANSCRIPTIONAL_ACTIVATION": "Pathway Definition from KEGG: CDX2* => (MUC2,CDH17,REG4,ABCB1)", "KEGG_MEDICUS_VARIANT_CDH1_REDUCED_EXPRESSION_TO_BETA_CATENIN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: CDH1* // CTNNB1 -> TCF/LEF => (MYC,CCND1)", "KEGG_MEDICUS_VARIANT_DELETED_DMD_TO_DYSTROPHIN_ASSOCIATED_PROTEIN_COMPLEX": "Pathway Definition from KEGG: (DAG1+(SNTA1,SNTB1,SNTB2,SNTG1,SNTG2)+DTNA) // DMD* // (ACTB,ACTG1)", "KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ACTH -> (MC2R+MRAP) -> GNAS -> ADCY -> cAMP -> PKA -> (NR5A1,NR4A1,SP1,PBX1,CREB) => CYP11B2* -> Aldosterone", "KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FLT3* -> STAT5 => PIM1/2", "KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FLT3* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FLT3* -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGFR* -> PI3K -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF* -> EGFR -> PI3K -> PIP3 -> AKT", "KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF* -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EML4-ALK -> JAK3 -> STAT3,STAT5", "KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EML4-ALK -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EML4-ALK -> RAS -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EML4-ALK -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> (ERBB2*+EGFR) -> PI3K -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_EGF_JAK_STAT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGF -> (ERBB2*+EGFR) -> JAK1 -> STAT1/3 => VEGFA", "KEGG_MEDICUS_VARIANT_ESR1_POSITIVE_TO_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY": "Pathway Definition from KEGG: E2 -> (ESR*+(NCOA3,NCOA1)) => (CCND1,MYC)", "KEGG_MEDICUS_VARIANT_EWSR1_WT1_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION": "Pathway Definition from KEGG: EWSR1-WT1 => (PDGFA,IL2RB,BAIAP3,TSPAN7,MLF1)", "KEGG_MEDICUS_VARIANT_FUS_DDIT3_FUSION_TO_NFKB_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: FUS-DDIT3 == (NFKBIZ+NFKB) => CXCL8", "KEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: HRAS* -> RAF -> MEK -> ERK -> MSK1 -> MYC", "KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: WNT -> (FZD7*+LRP5/6) -> (DVL+FRAT) -| (GSK3B+AXIN+APC) -| CTNNB1 -> TCF/LEF => (MYC,CCND1)", "KEGG_MEDICUS_VARIANT_IGH_MMSET_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION": "Pathway Definition from KEGG: IGH-MMSET -> H3 => CCND2", "KEGG_MEDICUS_VARIANT_LMO2_REARRANGEMENT_TO_TRANSCRIPTIONAL_ACTIVATION": "Pathway Definition from KEGG: (LMO2*+LDB1) == (LYL1+TCF3) => HHEX", "KEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: IGF2* -> IGF1R -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_LOSS_OF_CDKN1B_TO_P27_CELL_CYCLE_G1_S": "Pathway Definition from KEGG: CDKN1B* // (CCNE+CDK2) -> RB1 // E2F", "KEGG_MEDICUS_VARIANT_LMO2_REARRANGEMENT_TO_TRANSCRIPTIONAL_REPRESSION": "Pathway Definition from KEGG: (LMO2*+LDB1) == (LYL1+TCF3) =| PTCRA", "KEGG_MEDICUS_VARIANT_LOSS_OF_NKX3_1_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: NKX3-1* // AKT -| BAD", "KEGG_MEDICUS_VARIANT_LOSS_OF_RASSF1_TO_RAS_RASSF1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: RAS // (RASSF1*+RASSF5) // STK4", "KEGG_MEDICUS_VARIANT_LOSS_OF_VHL_TO_HIF_1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (VHL*+RBX1+ELOC+ELOB+CUL2) // HIF1A == ARNT => (SLC2A1,VEGFA,TGFB,PDGFB,TGFA)", "KEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: WNT -> (FZD+LRP6*) -> (DVL+FRAT) -| (GSK3B+AXIN+APC) -| CTNNB1 -> TCF/LEF => (MYC,CCND1)", "KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: MET* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_MLL_AF4_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION": "Pathway Definition from KEGG: MLL-AF4 == ((CDK9,CCNT)+(MLLT1,MLLT3)+DOT1L) => (LMO2,PBX3,RUNX2,SMAD1,KLF3,MEF2C,HOXA9,HOXA10,JMJD1C,HMGA2,KDM6A,SUPT3H,PROM1,FLT3,BMP2K,IGF1R,CDKN1B,CDK14)", "KEGG_MEDICUS_VARIANT_MLL_ENL_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION": "Pathway Definition from KEGG: MLL-ENL => (MEIS1,HOXA9,HOXA10,HOXA11,SIX1,SIX4,EYA1,CDKN2C,HPGD,GRIA3,FUT8)", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_BRAF_TO_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: BRAF* -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGFR* -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_CACNA1D_H_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (CACNA1D*,CACNA1H*) -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGFR* -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: EGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FGFR3* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> MSK1 -> MYC", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GNAS* -> ADCY -> cAMP -> PKA -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: GNAS* -> ADCY -> cAMP -> PKA -> CREB -> ACTH", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KCNJ5_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: KCNJ5* -> Na+ -> (CACNA1D,CACNA1H) -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: KIT* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: KIT* -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (KRAS*,NRAS*) -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (KRAS*,NRAS*) -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_LRRK2_TO_INTRINSIC_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: LRRK2* -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: MET* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: MET* -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PI3K* -> PIP3 -> AKT -> MTOR -> S6K", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: Glutamate -> GRM1 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -> PRKCG* -| TRPC3", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKACA_TO_ACTH_CORTISOL_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PRKACA* -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: RET* -> PI3K -> PIP3 -> AKT -> MTOR", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_USP8_TO_EGFR_ERK_ACTH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: USP8* -> EGFR -> ERK1/2 -> ACTH", "KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SMO* -> (SUFU+KIF7) // GLI => (BMP2/4,HHIP,GLI1,PTCH,WNT)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABBERANT_ATXN2_3_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: Glutamate -> GRM1 -> GNAQ -> PLCB -> IP3 -> (ITPR1+(ATXN2*,ATXN3*)) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: APP* -> Abeta -> AGER -> RAS -> RAF -> MEK -> ERK -> NFKB => (TNF,IL6,NOS2)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_ANTEROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: APP* -> Abeta -> CHRNA7 -> Ca2+ -> CAPN -> CDK5R1 == CDK5 -> MAPT -| (TUBA+TUBB)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_26S_PROTEASOME_MEDIATED_PROTEIN_DEGRADATION": "Pathway Definition from KEGG: APP* -> Abeta -| 26S", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS": "Pathway Definition from KEGG: APP* -> Abeta -> FAS -> FADD -> CASP8 -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_ELECTRON_TRANSFER_IN_COMPLEX_IV": "Pathway Definition from KEGG: APP* -> Abeta -| CxIV -> H2O", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: APP* -> Abeta -> mAChR -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_ELECTRON_TRANSFER_IN_COMPLEX_I": "Pathway Definition from KEGG: APP* -> Abeta -> CHRNA7 -> Ca2+ -> CAPN -> CDK5R1 == CDK5 -> MAPT -| CxI -> Q", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: APP* -> Abeta -> GRM5 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_IRE1A_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: APP* -> Abeta -> MAP3K5 -> MAP2K7 -> JNK", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_TRANSPORT_OF_CALCIUM": "Pathway Definition from KEGG: APP* -> Abeta -> NMDAR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004": "Pathway Definition from KEGG: APP* -> Abeta -> VGCC(L-type) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01006": "Pathway Definition from KEGG: APP* -> Abeta -> PPID -> MPTP -> CYCS", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_DCTN1_TO_RETROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: DCTN1* // (TUBA+TUBB)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ATXN1_TO_RORA_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: ATXN1* -| (RORA+KAT5) => (ITPR1,SLC1A6,GRM1)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_26S_PROTEASOME_MEDIATED_PROTEIN_DEGRADATION": "Pathway Definition from KEGG: HTT* -| 26S", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ANTEROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: HTT* -> JNK3 -| (KIF5+KLC) == (TUBA+TUBB)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_CREB_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: HTT* -| (CREB+TAF4) => PPARGC1A", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_AUTOPHAGY_VESICLE_NUCLEATION": "Pathway Definition from KEGG: HTT* -| (BECN1+PIK3C3+ATG14+PIK3R4+AMBRA1)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ELECTRON_TRANSFER_IN_COMPLEX_II": "Pathway Definition from KEGG: HTT* -| CxII -> QH2", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ELECTRON_TRANSFER_IN_COMPLEX_III": "Pathway Definition from KEGG: HTT* -| CxIII -> CytC", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: Glutamate -> GRM5 -> GNAQ -> PLCB -> IP3 -> (ITPR+HTT*) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_EXTRINSIC_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: HTT* // (HIP1+IFT57) -> CASP8 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_REST_MEDIATED_TRANSCRIPTIONAL_REPRESSION": "Pathway Definition from KEGG: HTT* // REST == (SIN3A+RCOR1+(HDAC1,HDAC2)) =| BDNF", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: (HTT*+HAP1) -| (DCTN+DNAH+DNAI+DNALI1+DNAL) == (TUBA+TUBB)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TNF_JNK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: HTT* -> MLK2 -> MKK7 -> JNK", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM": "Pathway Definition from KEGG: HTT* // DLG4 -> NMDAR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM": "Pathway Definition from KEGG: PDYN* -> NMDAR -> Ca2+", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_ANTEROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: PSEN1* -> GSK3B -| (KIF5+KLC)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: PSEN1* -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_PERK_ATF4_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PSEN1* -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: (PSEN1*,PSEN2*) -> RYR3 -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_26S_PROTEASOME_MEDIATED_PROTEIN_DEGRADATION": "Pathway Definition from KEGG: SNCA* -| 26S", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_ANTEROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: SNCA* -| (KIF5+KLC) // (TUBA+TUBB)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_PERK_ATF4_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SNCA* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_ELECTRON_TRANSFER_IN_COMPLEX_I": "Pathway Definition from KEGG: SNCA* -| CxI -> Q", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_VGCC_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: Ca2+(extracellular) -- SNCA* -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_INTRINSIC_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: SOD1* -| BCL2 -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_PERK_ATF4_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SOD1* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_26S_PROTEASOME_MEDIATED_PROTEIN_DEGRADATION": "Pathway Definition from KEGG: SOD1* -| DERL1 -> (Protein+UB) -- 26S -> Peptide", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: SOD1* -| (DCTN+DNAH+DNAI+DNALI1+DNAL)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY": "Pathway Definition from KEGG: SPTBN2* -| GRM1 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_APC_TO_WNT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (GSK3B+AXIN) // APC* // CTNNB1 -> TCF/LEF => (BIRC5,MYC,CCND1)", "KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_TDP43_TO_ELECTRON_TRANSFER_IN_COMPLEX_I": "Pathway Definition from KEGG: TARDBP* -| CxI -> Q", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP1A1_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ATP1A1* -> Na+ -> (CACNA1D,CACNA1H) -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP2B3_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY": "Pathway Definition from KEGG: ATP2B3* -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATXN3_TO_AUTOPHAGY_VESICLE_NUCLEATION": "Pathway Definition from KEGG: ATXN3* // (BECN1+PIK3C3+ATG14+PIK3R4+AMBRA1)", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_AXIN_TO_WNT_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (GSK3B+APC) // AXIN* // CTNNB1 -> TCF/LEF => (MYC,CCND1)", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_DJ1_TO_FAS_JNK_SIGNALING_PATWHAY": "Pathway Definition from KEGG: DJ1* // (DAXX+ASK1) -> JNK", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ERBB4_TO_NRG_ERBB4_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: NRG // ERBB4*", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_OPTN_TO_PINK_PARKIN_MEDIATED_AUTOPHAGOSOME_FORMATION": "Pathway Definition from KEGG: PINK1 -> PRKN -> (CISD1,CISD2,FAF2,FKBP8,TOMM70,HK1) // OPTN*", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: FGF17* // FGFR1 -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_P62_TO_PINK_PARKIN_MEDIATED_AUTOPHAGOSOME_FORMATION": "Pathway Definition from KEGG: PINK1 -> PRKN -> (CISD1,CISD2,FAF2,FKBP8,TOMM70,HK1) // SQSTM1* // LC3", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PINK1_TO_INTRINSIC_APOPTOTIC_PATHWAY_N01050": "Pathway Definition from KEGG: PINK1* // PRKN // BAX -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PDE11A_PDE8B_TO_ACTH_CORTISOL_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (PDE11A*,PDE8B*) // cAMP -> (PRKAR1A+PRKACA) -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PINK1_TO_INTRINSIC_APOPTOTIC_PATHWAY_N01048": "Pathway Definition from KEGG: PINK1* // (HTRA2,TRAP1) // CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PINK1_TO_ELECTRON_TRANSFER_IN_COMPLEX_I": "Pathway Definition from KEGG: PINK1* -| CxI -> Q", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKAR1A_TO_ACTH_CORTISOL_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (PRKAR1A*+PRKACA) -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_INTRINSIC_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: PRKN* // BAX -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROK2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PROK2* -> PROKR1/2 -> GNAI -> ERK", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PRKN* -> PLCG1 -> IP3 -> ITPR -> Ca2+", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROKR2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PROK1/2 -> PROKR2* -> GNAI -> ERK", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PTCH1* // SMO -> (SUFU+KIF7) // GLI => (BMP2/4,HHIP,GLI1,PTCH,WNT)", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RUNX1_TO_TRANSCRIPTION": "Pathway Definition from KEGG: RUNX1* // (CSF1R,MPO,CSF2,IL3)", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: RASD1* // GNAI // ADCY -> cAMP -> PKA -> CREB -> ACTH", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: SIGMAR1* -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_TP53_TO_TRANSCRIPTION": "Pathway Definition from KEGG: TP53* // (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)", "KEGG_MEDICUS_VARIANT_OLIGOMERIC_CONFORMATION_PRPC_TO_ANTEROGRADE_AXONAL_TRANSPORT": "Pathway Definition from KEGG: PRNP* -> (GSK3B,CK2) -| (KIF5+KLC)", "KEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY": "Pathway Definition from KEGG: (DLL,JAG) -> (NOTCH1*,NOTCH4*) -> (NICD+RBPJ) => (ERBB2,HES1,HES5,HEY,FLT4)", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_VCP_TO_26S_PROTEASOME_MEDIATED_PROTEIN_DEGRADATION": "Pathway Definition from KEGG: VCP* -| (Protein+UB) -- 26S -> Peptide", "KEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION": "Pathway Definition from KEGG: PAX8-PPARG -| (RXR+PPARG)", "KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_UBQLN2_TO_26S_PROTEASOME_MEDIATED_PROTEIN_DEGRADATION": "Pathway Definition from KEGG: UBQLN2* -| (Protein+UB) -- 26S -> Peptide", "KEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: RET* -> RAS -> RAF -> MEK -> ERK", "KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: PRNP* -> (RYR,ITPR) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_PERK_ATF4_SIGNALING_PATHWAY": "Pathway Definition from KEGG: PRNP* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3", "KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM": "Pathway Definition from KEGG: PRNP* -> NMDAR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3", "KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_26S_PROTEASOME_MEDIATED_PROTEIN_DEGRADATION": "Pathway Definition from KEGG: PRNP* -| 26S", "KEGG_MEDICUS_VARIANT_TEL_AML1_FUSION_TO_TRANSCRIPTIONAL_REPRESSION": "Pathway Definition from KEGG: TEL-AML1 == (HDAC+SIN3A+NCOR1) =| (IL3,CSF2,MPO,DEFA3,ELANE,GZMB)", "KEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TGFA* -> EGFR -> PI3K -> PIP3 -> AKT", "KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY": "Pathway Definition from KEGG: PRNP* -| VGCC(N,L-type) -> Ca2+", "KEGG_MEDICUS_VARIANT_TMPRSS2_ERG_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION": "Pathway Definition from KEGG: TMPRSS2-ERG => (PLAU,PLAT,MMP3,MMP9,ZEB1,IL1R2)", "KEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY": "Pathway Definition from KEGG: TRK* -> RAS -> RAF -> MEK -> ERK", "PID_A6B1_A6B4_INTEGRIN_PATHWAY": "a6b1 and a6b4 Integrin signaling", "PID_AJDISS_2PATHWAY": "Posttranslational regulation of adherens junction stability and dissassembly", "PID_ALK1_PATHWAY": "ALK1 signaling events", "PID_ALK2_PATHWAY": "ALK2 signaling events", "PID_ALPHA_SYNUCLEIN_PATHWAY": "Alpha-synuclein signaling", "PID_AMB2_NEUTROPHILS_PATHWAY": "amb2 Integrin signaling", "PID_ANGIOPOIETIN_RECEPTOR_PATHWAY": "Angiopoietin receptor Tie2-mediated signaling", "PID_ANTHRAX_PATHWAY": "Cellular roles of Anthrax toxin", "PID_AP1_PATHWAY": "AP-1 transcription factor network", "PID_ARF6_DOWNSTREAM_PATHWAY": "Arf6 downstream pathway", "PID_ARF6_PATHWAY": "Arf6 signaling events", "PID_ARF_3PATHWAY": "Arf1 pathway", "PID_ARF6_TRAFFICKING_PATHWAY": "Arf6 trafficking events", "PID_AR_PATHWAY": "Coregulation of Androgen receptor activity", "PID_AR_NONGENOMIC_PATHWAY": "Nongenotropic Androgen signaling", "PID_AR_TF_PATHWAY": "Regulation of Androgen receptor activity", "PID_ATM_PATHWAY": "ATM pathway", "PID_ATF2_PATHWAY": "ATF-2 transcription factor network", "PID_AURORA_A_PATHWAY": "Aurora A signaling", "PID_ATR_PATHWAY": "ATR signaling pathway", "PID_AURORA_B_PATHWAY": "Aurora B signaling", "PID_AVB3_OPN_PATHWAY": "Osteopontin-mediated events", "PID_AVB3_INTEGRIN_PATHWAY": "Integrins in angiogenesis", "PID_BCR_5PATHWAY": "BCR signaling pathway", "PID_BARD1_PATHWAY": "BARD1 signaling events", "PID_BETA_CATENIN_DEG_PATHWAY": "Degradation of beta catenin", "PID_BMP_PATHWAY": "BMP receptor signaling", "PID_BETA_CATENIN_NUC_PATHWAY": "Regulation of nuclear beta catenin signaling and target gene transcription", "PID_CASPASE_PATHWAY": "Caspase cascade in apoptosis", "PID_CD40_PATHWAY": "CD40/CD40L signaling", "PID_CD8_TCR_DOWNSTREAM_PATHWAY": "Downstream signaling in na\u00efve CD8+ T cells", "PID_CDC42_PATHWAY": "CDC42 signaling events", "PID_CD8_TCR_PATHWAY": "TCR signaling in na\u00efve CD8+ T cells", "PID_CDC42_REG_PATHWAY": "Regulation of CDC42 activity", "PID_CERAMIDE_PATHWAY": "Ceramide signaling pathway", "PID_CIRCADIAN_PATHWAY": "Circadian rhythm pathway", "PID_CMYB_PATHWAY": "C-MYB transcription factor network", "PID_CONE_PATHWAY": "Visual signal transduction: Cones", "PID_CXCR3_PATHWAY": "CXCR3-mediated signaling events", "PID_CXCR4_PATHWAY": "CXCR4-mediated signaling events", "PID_E2F_PATHWAY": "E2F transcription factor network", "PID_DELTA_NP63_PATHWAY": "Validated transcriptional targets of deltaNp63 isoforms", "PID_DNA_PK_PATHWAY": "DNA-PK pathway in nonhomologous end joining", "PID_ECADHERIN_NASCENT_AJ_PATHWAY": "E-cadherin signaling in the nascent adherens junction", "PID_ECADHERIN_KERATINOCYTE_PATHWAY": "E-cadherin signaling in keratinocytes", "PID_ENDOTHELIN_PATHWAY": "Endothelins", "PID_ECADHERIN_STABILIZATION_PATHWAY": "Stabilization and expansion of the E-cadherin adherens junction", "PID_EPHA2_FWD_PATHWAY": "EPHA2 forward signaling", "PID_EPHA_FWDPATHWAY": "EPHA forward signaling", "PID_EPHB_FWD_PATHWAY": "EPHB forward signaling", "PID_EPHRINB_REV_PATHWAY": "Ephrin B reverse signaling", "PID_ERA_GENOMIC_PATHWAY": "Validated nuclear estrogen receptor alpha network", "PID_EPO_PATHWAY": "EPO signaling pathway", "PID_ERBB1_INTERNALIZATION_PATHWAY": "Internalization of ErbB1", "PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY": "EGF receptor (ErbB1) signaling pathway", "PID_ERBB2_ERBB3_PATHWAY": "ErbB2/ErbB3 signaling events", "PID_ERBB1_DOWNSTREAM_PATHWAY": "ErbB1 downstream signaling", "PID_ERBB4_PATHWAY": "ErbB4 signaling events", "PID_ERBB_NETWORK_PATHWAY": "ErbB receptor signaling network", "PID_ERB_GENOMIC_PATHWAY": "Validated nuclear estrogen receptor beta network", "PID_FANCONI_PATHWAY": "Fanconi anemia pathway", "PID_ER_NONGENOMIC_PATHWAY": "Plasma membrane estrogen receptor signaling", "PID_FAK_PATHWAY": "Signaling events mediated by focal adhesion kinase", "PID_FAS_PATHWAY": "FAS (CD95) signaling pathway", "PID_FGF_PATHWAY": "FGF signaling pathway", "PID_FCER1_PATHWAY": "Fc-epsilon receptor I signaling in mast cells", "PID_FOXM1_PATHWAY": "FOXM1 transcription factor network", "PID_FOXO_PATHWAY": "FoxO family signaling", "PID_FRA_PATHWAY": "Validated transcriptional targets of AP1 family members Fra1 and Fra2", "PID_GMCSF_PATHWAY": "GMCSF-mediated signaling events", "PID_HDAC_CLASSIII_PATHWAY": "Signaling events mediated by HDAC Class III", "PID_GLYPICAN_1PATHWAY": "Glypican 1 network", "PID_HDAC_CLASSII_PATHWAY": "Signaling events mediated by HDAC Class II", "PID_HDAC_CLASSI_PATHWAY": "Signaling events mediated by HDAC Class I", "PID_HEDGEHOG_2PATHWAY": "Signaling events mediated by the Hedgehog family", "PID_HES_HEY_PATHWAY": "Notch-mediated HES/HEY network", "PID_HEDGEHOG_GLI_PATHWAY": "Hedgehog signaling events mediated by Gli proteins", "PID_HIF1A_PATHWAY": "Hypoxic and oxygen homeostasis regulation of HIF-1-alpha", "PID_HIF1_TFPATHWAY": "HIF-1-alpha transcription factor network", "PID_HNF3A_PATHWAY": "FOXA1 transcription factor network", "PID_HIV_NEF_PATHWAY": "HIV-1 Nef: Negative effector of Fas and TNF-alpha", "PID_HIF2PATHWAY": "HIF-2-alpha transcription factor network", "PID_HNF3B_PATHWAY": "FOXA2 and FOXA3 transcription factor networks", "PID_IFNG_PATHWAY": "IFN-gamma pathway", "PID_IGF1_PATHWAY": "IGF1 pathway", "PID_IL12_2PATHWAY": "IL12-mediated signaling events", "PID_IL23_PATHWAY": "IL23-mediated signaling events", "PID_IL12_STAT4_PATHWAY": "IL12 signaling mediated by STAT4", "PID_IL1_PATHWAY": "IL1-mediated signaling events", "PID_IL27_PATHWAY": "IL27-mediated signaling events", "PID_IL2_PI3K_PATHWAY": "IL2 signaling events mediated by PI3K", "PID_IL2_1PATHWAY": "IL2-mediated signaling events", "PID_IL2_STAT5_PATHWAY": "IL2 signaling events mediated by STAT5", "PID_IL4_2PATHWAY": "IL4-mediated signaling events", "PID_IL3_PATHWAY": "IL3-mediated signaling events", "PID_IL5_PATHWAY": "IL5-mediated signaling events", "PID_IL6_7_PATHWAY": "IL6-mediated signaling events", "PID_IL8_CXCR2_PATHWAY": "IL8- and CXCR2-mediated signaling events", "PID_IL8_CXCR1_PATHWAY": "IL8- and CXCR1-mediated signaling events", "PID_ILK_PATHWAY": "Integrin-linked kinase signaling", "PID_INSULIN_GLUCOSE_PATHWAY": "Insulin-mediated glucose transport", "PID_INSULIN_PATHWAY": "Insulin Pathway", "PID_INTEGRIN2_PATHWAY": "Beta2 integrin cell surface interactions", "PID_INTEGRIN3_PATHWAY": "Beta3 integrin cell surface interactions", "PID_INTEGRIN1_PATHWAY": "Beta1 integrin cell surface interactions", "PID_INTEGRIN_A9B1_PATHWAY": "Alpha9 beta1 integrin signaling events", "PID_INTEGRIN5_PATHWAY": "Beta5 beta6 beta7 and beta8 integrin cell surface interactions", "PID_INTEGRIN4_PATHWAY": "Alpha6 beta4 integrin-ligand interactions", "PID_INTEGRIN_A4B1_PATHWAY": "Alpha4 beta1 integrin signaling events", "PID_KIT_PATHWAY": "Signaling events mediated by Stem cell factor receptor (c-Kit)", "PID_INTEGRIN_CS_PATHWAY": "Integrin family cell surface interactions", "PID_LPA4_PATHWAY": "LPA4-mediated signaling events", "PID_LIS1_PATHWAY": "Lissencephaly gene (LIS1) in neuronal migration and development", "PID_LKB1_PATHWAY": "LKB1 signaling events", "PID_LYMPH_ANGIOGENESIS_PATHWAY": "VEGFR3 signaling in lymphatic endothelium", "PID_LYSOPHOSPHOLIPID_PATHWAY": "LPA receptor mediated events", "PID_MAPK_TRK_PATHWAY": "Trk receptor signaling mediated by the MAPK pathway", "PID_MTOR_4PATHWAY": "mTOR signaling pathway", "PID_MET_PATHWAY": "Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)", "PID_MYC_PATHWAY": "C-MYC pathway", "PID_MYC_ACTIV_PATHWAY": "Validated targets of C-MYC transcriptional activation", "PID_NCADHERIN_PATHWAY": "N-cadherin signaling events", "PID_NEPHRIN_NEPH1_PATHWAY": "Nephrin/Neph1 signaling in the kidney podocyte", "PID_MYC_REPRESS_PATHWAY": "Validated targets of C-MYC transcriptional repression", "PID_NECTIN_PATHWAY": "Nectin adhesion pathway", "PID_NFAT_3PATHWAY": "Role of Calcineurin-dependent NFAT signaling in lymphocytes", "PID_NFKAPPAB_ATYPICAL_PATHWAY": "Atypical NF-kappaB pathway", "PID_NETRIN_PATHWAY": "Netrin-mediated signaling events", "PID_NFAT_TFPATHWAY": "Calcineurin-regulated NFAT-dependent transcription in lymphocytes", "PID_NOTCH_PATHWAY": "Notch signaling pathway", "PID_NFKAPPAB_CANONICAL_PATHWAY": "Canonical NF-kappaB pathway", "PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY": "Signaling mediated by p38-alpha and p38-beta", "PID_P38_ALPHA_BETA_PATHWAY": "Regulation of p38-alpha and p38-beta", "PID_P38_GAMMA_DELTA_PATHWAY": "Signaling mediated by p38-gamma and p38-delta", "PID_P38_MK2_PATHWAY": "p38 signaling mediated by MAPKAP kinases", "PID_P38_MKK3_6PATHWAY": "p38 MAPK signaling pathway", "PID_P73PATHWAY": "p73 transcription factor network", "PID_PDGFRA_PATHWAY": "PDGFR-alpha signaling pathway", "PID_P53_REGULATION_PATHWAY": "p53 pathway", "PID_P53_DOWNSTREAM_PATHWAY": "Direct p53 effectors", "PID_P75_NTR_PATHWAY": "p75(NTR)-mediated signaling", "PID_PDGFRB_PATHWAY": "PDGFR-beta signaling pathway", "PID_PI3KCI_AKT_PATHWAY": "Class I PI3K signaling events mediated by Akt", "PID_PI3KCI_PATHWAY": "Class I PI3K signaling events", "PID_PI3K_PLC_TRK_PATHWAY": "Trk receptor signaling mediated by PI3K and PLC-gamma", "PID_PLK1_PATHWAY": "PLK1 signaling events", "PID_PRL_SIGNALING_EVENTS_PATHWAY": "Signaling events mediated by PRL", "PID_RAC1_REG_PATHWAY": "Regulation of RAC1 activity", "PID_RAC1_PATHWAY": "RAC1 signaling pathway", "PID_PTP1B_PATHWAY": "Signaling events mediated by PTP1B", "PID_PS1_PATHWAY": "Presenilin action in Notch and Wnt signaling", "PID_RANBP2_PATHWAY": "Sumoylation by RanBP2 regulates transcriptional repression", "PID_RAS_PATHWAY": "Regulation of Ras family activation", "PID_RB_1PATHWAY": "Regulation of retinoblastoma protein", "PID_REELIN_PATHWAY": "Reelin signaling pathway", "PID_REG_GR_PATHWAY": "Glucocorticoid receptor regulatory network", "PID_RETINOIC_ACID_PATHWAY": "Retinoic acid receptors-mediated signaling", "PID_RHOA_PATHWAY": "RhoA signaling pathway", "PID_RHODOPSIN_PATHWAY": "Visual signal transduction: Rods", "PID_RET_PATHWAY": "Signaling events regulated by Ret tyrosine kinase", "PID_RHOA_REG_PATHWAY": "Regulation of RhoA activity", "PID_RXR_VDR_PATHWAY": "RXR and RAR heterodimerization with other nuclear receptor", "PID_S1P_META_PATHWAY": "Sphingosine 1-phosphate (S1P) pathway", "PID_S1P_S1P2_PATHWAY": "S1P2 pathway", "PID_S1P_S1P1_PATHWAY": "S1P1 pathway", "PID_S1P_S1P4_PATHWAY": "S1P4 pathway", "PID_S1P_S1P3_PATHWAY": "S1P3 pathway", "PID_SYNDECAN_1_PATHWAY": "Syndecan-1-mediated signaling events", "PID_SMAD2_3NUCLEAR_PATHWAY": "Regulation of nuclear SMAD2/3 signaling", "PID_SMAD2_3PATHWAY": "Regulation of cytoplasmic and nuclear SMAD2/3 signaling", "PID_SHP2_PATHWAY": "SHP2 signaling", "PID_SYNDECAN_2_PATHWAY": "Syndecan-2-mediated signaling events", "PID_SYNDECAN_3_PATHWAY": "Syndecan-3-mediated signaling events", "PID_SYNDECAN_4_PATHWAY": "Syndecan-4-mediated signaling events", "PID_TAP63_PATHWAY": "Validated transcriptional targets of TAp63 isoforms", "PID_TCPTP_PATHWAY": "Signaling events mediated by TCPTP", "PID_TCR_CALCIUM_PATHWAY": "Calcium signaling in the CD4+ TCR pathway", "PID_TCR_PATHWAY": "TCR signaling in na\u00efve CD4+ T cells", "PID_TELOMERASE_PATHWAY": "Regulation of Telomerase", "PID_TCR_RAS_PATHWAY": "Ras signaling in the CD4+ TCR pathway", "PID_TCR_JNK_PATHWAY": "JNK signaling in the CD4+ TCR pathway", "PID_THROMBIN_PAR1_PATHWAY": "PAR1-mediated thrombin signaling events", "PID_TGFBR_PATHWAY": "TGF-beta receptor signaling", "PID_THROMBIN_PAR4_PATHWAY": "PAR4-mediated thrombin signaling events", "PID_TNF_PATHWAY": "TNF receptor signaling pathway", "PID_TRAIL_PATHWAY": "TRAIL signaling pathway", "PID_TOLL_ENDOGENOUS_PATHWAY": "Endogenous TLR signaling", "PID_TRKR_PATHWAY": "Neurotrophic factor-mediated Trk receptor signaling", "PID_TXA2PATHWAY": "Thromboxane A2 receptor signaling", "PID_VEGFR1_2_PATHWAY": "Signaling events mediated by VEGFR1 and VEGFR2", "PID_VEGFR1_PATHWAY": "VEGFR1 specific signals", "PID_UPA_UPAR_PATHWAY": "Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling", "REACTOME_2_LTR_CIRCLE_FORMATION": "2-LTR circle formation", "PID_WNT_CANONICAL_PATHWAY": "Canonical Wnt signaling pathway", "PID_VEGF_VEGFR_PATHWAY": "VEGF and VEGFR signaling network", "PID_WNT_NONCANONICAL_PATHWAY": "Noncanonical Wnt signaling pathway", "PID_WNT_SIGNALING_PATHWAY": "Wnt signaling network", "REACTOME_ABACAVIR_ADME": "Abacavir ADME", "REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT": "Abacavir transmembrane transport", "REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS": "ABC transporters in lipid homeostasis", "REACTOME_ABC_TRANSPORTER_DISORDERS": "ABC transporter disorders", "REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT": "ABC-family proteins mediated transport", "REACTOME_ABERRANT_REGULATION_OF_MITOTIC_EXIT_IN_CANCER_DUE_TO_RB1_DEFECTS": "Aberrant regulation of mitotic exit in cancer due to RB1 defects", "REACTOME_ABORTIVE_ELONGATION_OF_HIV_1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT": "Abortive elongation of HIV-1 transcript in the absence of Tat", "REACTOME_ACETYLCHOLINE_INHIBITS_CONTRACTION_OF_OUTER_HAIR_CELLS": "Acetylcholine inhibits contraction of outer hair cells", "REACTOME_ABERRANT_REGULATION_OF_MITOTIC_G1_S_TRANSITION_IN_CANCER_DUE_TO_RB1_DEFECTS": "Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects", "REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS": "Acetylcholine binding and downstream events", "REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE": "Acetylcholine Neurotransmitter Release Cycle", "REACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION": "Acetylcholine regulates insulin secretion", "REACTOME_ACROSOME_REACTION_AND_SPERM_OOCYTE_MEMBRANE_BINDING": "Acrosome Reaction and Sperm:Oocyte Membrane Binding", "REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS": "Activated NOTCH1 Transmits Signal to the Nucleus", "REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_CDK5": "Activated NTRK2 signals through CDK5", "REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3": "Activated NTRK2 signals through FRS2 and FRS3", "REACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_PI3K": "Activated NTRK3 signals through PI3K", "REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_PI3K": "Activated NTRK2 signals through PI3K", "REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_RAS": "Activated NTRK2 signals through RAS", "REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FYN": "Activated NTRK2 signals through FYN", "REACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_RAS": "Activated NTRK3 signals through RAS", "REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION": "activated TAK1 mediates p38 MAPK activation", "REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3": "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "REACTOME_ACTIVATION_OF_AMPK_DOWNSTREAM_OF_NMDARS": "Activation of AMPK downstream of NMDARs", "REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS": "Activation of ATR in response to replication stress", "REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS": "Activation of BH3-only proteins", "REACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA": "Activation of BAD and translocation to mitochondria", "REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS": "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "REACTOME_ACTIVATION_OF_CASPASES_THROUGH_APOPTOSOME_MEDIATED_CLEAVAGE": "Activation of caspases through apoptosome-mediated cleavage", "REACTOME_ACTIVATION_OF_C3_AND_C5": "Activation of C3 and C5", "REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_IKBKE": "Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)", "REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP": "Activation of gene expression by SREBF (SREBP)", "REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING": "Activation of kainate receptors upon glutamate binding", "REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES": "Activation of Matrix Metalloproteinases", "REACTOME_ACTIVATION_OF_NIMA_KINASES_NEK9_NEK6_NEK7": "Activation of NIMA Kinases NEK9, NEK6, NEK7", "REACTOME_ACTIVATION_OF_PPARGC1A_PGC_1ALPHA_BY_PHOSPHORYLATION": "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "REACTOME_ACTIVATION_OF_NOXA_AND_TRANSLOCATION_TO_MITOCHONDRIA": "Activation of NOXA and translocation to mitochondria", "REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS": "Activation of NMDA receptors and postsynaptic events", "REACTOME_ACTIVATION_OF_RAC1": "Activation of RAC1", "REACTOME_ACTIVATION_OF_PUMA_AND_TRANSLOCATION_TO_MITOCHONDRIA": "Activation of PUMA and translocation to mitochondria", "REACTOME_ACTIVATION_OF_RAC1_DOWNSTREAM_OF_NMDARS": "Activation of RAC1 downstream of NMDARs", "REACTOME_ACTIVATION_OF_RAS_IN_B_CELLS": "Activation of RAS in B cells", "REACTOME_ACTIVATION_OF_SMO": "Activation of SMO", "REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS": "Activation of the AP-1 family of transcription factors", "REACTOME_ACTIVATION_OF_THE_PHOTOTRANSDUCTION_CASCADE": "Activation of the phototransduction cascade", "REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S": "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX": "Activation of the pre-replicative complex", "REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS": "Activation of the TFAP2 (AP-2) family of transcription factors", "REACTOME_ACTIVATION_OF_TRKA_RECEPTORS": "Activation of TRKA receptors", "REACTOME_ACYL_CHAIN_REMODELLING_OF_PG": "Acyl chain remodelling of PG", "REACTOME_ACYL_CHAIN_REMODELING_OF_CL": "Acyl chain remodeling of CL", "REACTOME_ACYL_CHAIN_REMODELING_OF_DAG_AND_TAG": "Acyl chain remodeling of DAG and TAG", "REACTOME_ACYL_CHAIN_REMODELLING_OF_PC": "Acyl chain remodelling of PC", "REACTOME_ACYL_CHAIN_REMODELLING_OF_PE": "Acyl chain remodelling of PE", "REACTOME_ACYL_CHAIN_REMODELLING_OF_PI": "Acyl chain remodelling of PI", "REACTOME_ACYL_CHAIN_REMODELLING_OF_PS": "Acyl chain remodelling of PS", "REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY": "Adenylate cyclase activating pathway", "REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY": "Adenylate cyclase inhibitory pathway", "REACTOME_ADRENOCEPTORS": "Adrenoceptors", "REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS": "Adherens junctions interactions", "REACTOME_ADAPTIVE_IMMUNE_SYSTEM": "Adaptive Immune System", "REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12": "ADP signalling through P2Y purinoceptor 12", "REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION": "ADORA2B mediated anti-inflammatory cytokines production", "REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION": "Adrenaline,noradrenaline inhibits insulin secretion", "REACTOME_ADIPOGENESIS": "Adipogenesis", "REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1": "ADP signalling through P2Y purinoceptor 1", "REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING": "Advanced glycosylation endproduct receptor signaling", "REACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION": "Aflatoxin activation and detoxification", "REACTOME_AEROBIC_RESPIRATION_AND_RESPIRATORY_ELECTRON_TRANSPORT": "Aerobic respiration and respiratory electron transport", "REACTOME_AGGREPHAGY": "Aggrephagy", "REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS": "AKT phosphorylates targets in the nucleus", "REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL": "AKT phosphorylates targets in the cytosol", "REACTOME_ALK_MUTANTS_BIND_TKIS": "ALK mutants bind TKIs", "REACTOME_ALPHA_DEFENSINS": "Alpha-defensins", "REACTOME_ALPHA_LINOLENIC_OMEGA3_AND_LINOLEIC_OMEGA6_ACID_METABOLISM": "alpha-linolenic (omega3) and linoleic (omega6) acid metabolism", "REACTOME_ALPHA_OXIDATION_OF_PHYTANATE": "Alpha-oxidation of phytanate", "REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY": "Alpha-protein kinase 1 signaling pathway", "REACTOME_ALTERNATIVE_COMPLEMENT_ACTIVATION": "Alternative complement activation", "REACTOME_AMINE_LIGAND_BINDING_RECEPTORS": "Amine ligand-binding receptors", "REACTOME_AMINO_ACID_CONJUGATION": "Amino Acid conjugation", "REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE": "", "REACTOME_AMPK_INHIBITS_CHREBP_TRANSCRIPTIONAL_ACTIVATION_ACTIVITY": "AMPK inhibits chREBP transcriptional activation activity", "REACTOME_AMINO_ACIDS_REGULATE_MTORC1": "Amino acids regulate mTORC1", "REACTOME_ANCHORING_FIBRIL_FORMATION": "Anchoring fibril formation", "REACTOME_ANDROGEN_BIOSYNTHESIS": "Androgen biosynthesis", "REACTOME_AMYLOID_FIBER_FORMATION": "Amyloid fiber formation", "REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE": "Anchoring of the basal body to the plasma membrane", "REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC": "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES": "", "REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION": "Antigen processing-Cross presentation", "REACTOME_ANTIMICROBIAL_PEPTIDES": "Antimicrobial peptides", "REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A": "APC-Cdc20 mediated degradation of Nek2A", "REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B": "APC/C:Cdc20 mediated degradation of Cyclin B", "REACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION": "Anti-inflammatory response favouring Leishmania parasite infection", "REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION": "Antigen processing: Ubiquitination & Proteasome degradation", "REACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS": "APC/C-mediated degradation of cell cycle proteins", "REACTOME_APEX1_INDEPENDENT_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY": "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV_1_INFECTION": "APOBEC3G mediated resistance to HIV-1 infection", "REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS": "Apoptotic cleavage of cell adhesion  proteins", "REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION": "Apoptosis induced DNA fragmentation", "REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS": "Apoptotic cleavage of cellular proteins", "REACTOME_APOPTOTIC_FACTOR_MEDIATED_RESPONSE": "Apoptotic factor-mediated response", "REACTOME_APOPTOTIC_EXECUTION_PHASE": "Apoptotic execution phase", "REACTOME_ARACHIDONATE_PRODUCTION_FROM_DAG": "Arachidonate production from DAG", "REACTOME_APOPTOSIS": "Apoptosis", "REACTOME_AQUAPORIN_MEDIATED_TRANSPORT": "Aquaporin-mediated transport", "REACTOME_ARACHIDONIC_ACID_METABOLISM": "", "REACTOME_ARMS_MEDIATED_ACTIVATION": "ARMS-mediated activation", "REACTOME_ARYL_HYDROCARBON_RECEPTOR_SIGNALLING": "Aryl hydrocarbon receptor signalling", "REACTOME_ASPARTATE_AND_ASPARAGINE_METABOLISM": "Aspartate and asparagine metabolism", "REACTOME_ASSEMBLY_OF_ACTIVE_LPL_AND_LIPC_LIPASE_COMPLEXES": "Assembly of active LPL and LIPC lipase complexes", "REACTOME_ASPIRIN_ADME": "Aspirin ADME", "REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION": "Asparagine N-linked glycosylation", "REACTOME_ASSEMBLY_OF_THE_HIV_VIRION": "Assembly Of The HIV Virion", "REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS": "Assembly and cell surface presentation of NMDA receptors", "REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES": "Assembly of collagen fibrils and other multimeric structures", "REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS": "Association of TriC/CCT with target proteins during biosynthesis", "REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION": "Assembly of the ORC complex at the origin of replication", "REACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS": "Asymmetric localization of PCP proteins", "REACTOME_ATF4_ACTIVATES_GENES_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "ATF4 activates genes in response to endoplasmic reticulum  stress", "REACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONES": "ATF6 (ATF6-alpha) activates chaperones", "REACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONE_GENES": "ATF6 (ATF6-alpha) activates chaperone genes", "REACTOME_ATORVASTATIN_ADME": "Atorvastatin ADME", "REACTOME_ATTACHMENT_AND_ENTRY": "Attachment and Entry", "REACTOME_ATTACHMENT_OF_GPI_ANCHOR_TO_UPAR": "Attachment of GPI anchor to uPAR", "REACTOME_ATTENUATION_PHASE": "Attenuation phase", "REACTOME_AUF1_HNRNP_D0_BINDS_AND_DESTABILIZES_MRNA": "AUF1 (hnRNP D0) binds and destabilizes mRNA", "REACTOME_AZATHIOPRINE_ADME": "Azathioprine ADME", "REACTOME_AURKA_ACTIVATION_BY_TPX2": "AURKA Activation by TPX2", "REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS": "", "REACTOME_BACTERIAL_INFECTION_PATHWAYS": "Bacterial Infection Pathways", "REACTOME_AUTOPHAGY": "Autophagy", "REACTOME_BASIGIN_INTERACTIONS": "Basigin interactions", "REACTOME_BBSOME_MEDIATED_CARGO_TARGETING_TO_CILIUM": "BBSome-mediated cargo-targeting to cilium", "REACTOME_BASE_EXCISION_REPAIR": "Base Excision Repair", "REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION": "Base-Excision Repair, AP Site Formation", "REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE": "Beta-catenin phosphorylation cascade", "REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING": "Beta-catenin independent WNT signaling", "REACTOME_BETA_OXIDATION_OF_BUTANOYL_COA_TO_ACETYL_COA": "Beta oxidation of butanoyl-CoA to acetyl-CoA", "REACTOME_BETA_DEFENSINS": "Beta defensins", "REACTOME_BETA_OXIDATION_OF_HEXANOYL_COA_TO_BUTANOYL_COA": "Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "REACTOME_BETA_OXIDATION_OF_DECANOYL_COA_TO_OCTANOYL_COA_COA": "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "REACTOME_BETA_OXIDATION_OF_LAUROYL_COA_TO_DECANOYL_COA_COA": "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "REACTOME_BETA_OXIDATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS": "Beta-oxidation of very long chain fatty acids", "REACTOME_BH3_ONLY_PROTEINS_ASSOCIATE_WITH_AND_INACTIVATE_ANTI_APOPTOTIC_BCL_2_MEMBERS": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "REACTOME_BETA_OXIDATION_OF_OCTANOYL_COA_TO_HEXANOYL_COA": "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "REACTOME_BICARBONATE_TRANSPORTERS": "Bicarbonate transporters", "REACTOME_BETA_OXIDATION_OF_PRISTANOYL_COA": "Beta-oxidation of pristanoyl-CoA", "REACTOME_BINDING_OF_TCF_LEF_CTNNB1_TO_TARGET_GENE_PROMOTERS": "Binding of TCF/LEF:CTNNB1 to target gene promoters", "REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM": "Bile acid and bile salt metabolism", "REACTOME_BIOSYNTHESIS_OF_EPA_DERIVED_SPMS": "Biosynthesis of EPA-derived SPMs", "REACTOME_BIOSYNTHESIS_OF_MARESINS": "Biosynthesis of maresins", "REACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS": "Binding and Uptake of Ligands by Scavenger Receptors", "REACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS": "Biosynthesis of maresin-like SPMs", "REACTOME_BIOLOGICAL_OXIDATIONS": "Biological oxidations", "REACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS": "Biosynthesis of specialized proresolving mediators (SPMs)", "REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM": "Biotin transport and metabolism", "REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN": "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "REACTOME_BLOOD_GROUP_SYSTEMS_BIOSYNTHESIS": "Blood group systems biosynthesis", "REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION": "", "REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM": "Branched-chain amino acid catabolism", "REACTOME_BUTYRATE_RESPONSE_FACTOR_1_BRF1_BINDS_AND_DESTABILIZES_MRNA": "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "REACTOME_BUTYROPHILIN_BTN_FAMILY_INTERACTIONS": "Butyrophilin (BTN) family interactions", "REACTOME_BUDDING_AND_MATURATION_OF_HIV_VIRION": "Budding and maturation of HIV virion", "REACTOME_CA2_ACTIVATED_K_CHANNELS": "Ca2+ activated K+ channels", "REACTOME_B_WICH_COMPLEX_POSITIVELY_REGULATES_RRNA_EXPRESSION": "B-WICH complex positively regulates rRNA expression", "REACTOME_CALCINEURIN_ACTIVATES_NFAT": "Calcineurin activates NFAT", "REACTOME_CA2_PATHWAY": "Ca2+ pathway", "REACTOME_CALNEXIN_CALRETICULIN_CYCLE": "Calnexin/calreticulin cycle", "REACTOME_CALCITONIN_LIKE_LIGAND_RECEPTORS": "Calcitonin-like ligand receptors", "REACTOME_CAMK_IV_MEDIATED_PHOSPHORYLATION_OF_CREB": "CaMK IV-mediated phosphorylation of CREB", "REACTOME_CARDIOGENESIS": "Cardiogenesis", "REACTOME_CARBOXYTERMINAL_POST_TRANSLATIONAL_MODIFICATIONS_OF_TUBULIN": "Carboxyterminal post-translational modifications of tubulin", "REACTOME_CARGO_CONCENTRATION_IN_THE_ER": "Cargo concentration in the ER", "REACTOME_CARDIAC_CONDUCTION": "Cardiac conduction", "REACTOME_CARNITINE_METABOLISM": "", "REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS": "Cargo recognition for clathrin-mediated endocytosis", "REACTOME_CARGO_TRAFFICKING_TO_THE_PERICILIARY_MEMBRANE": "Cargo trafficking to the periciliary membrane", "REACTOME_CASPASE_ACTIVATION_VIA_DEPENDENCE_RECEPTORS_IN_THE_ABSENCE_OF_LIGAND": "Caspase activation via Dependence Receptors in the absence of ligand", "REACTOME_CASPASE_ACTIVATION_VIA_DEATH_RECEPTORS_IN_THE_PRESENCE_OF_LIGAND": "Caspase activation via Death Receptors in the presence of ligand", "REACTOME_CASPASE_ACTIVATION_VIA_EXTRINSIC_APOPTOTIC_SIGNALLING_PATHWAY": "Caspase activation via extrinsic apoptotic signalling pathway", "REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS": "Caspase-mediated cleavage of cytoskeletal proteins", "REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS": "Cation-coupled Chloride cotransporters", "REACTOME_CD163_MEDIATING_AN_ANTI_INFLAMMATORY_RESPONSE": "CD163 mediating an anti-inflammatory response", "REACTOME_CA_DEPENDENT_EVENTS": "Ca-dependent events", "REACTOME_CD209_DC_SIGN_SIGNALING": "CD209 (DC-SIGN) signaling", "REACTOME_CD28_CO_STIMULATION": "", "REACTOME_CD22_MEDIATED_BCR_REGULATION": "CD22 mediated BCR regulation", "REACTOME_CD28_DEPENDENT_VAV1_PATHWAY": "CD28 dependent Vav1 pathway", "REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING": "CD28 dependent PI3K/Akt signaling", "REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX": "CDC6 association with the ORC:origin complex", "REACTOME_CDH11_HOMOTYPIC_AND_HETEROTYPIC_INTERACTIONS": "CDH11 homotypic and heterotypic interactions", "REACTOME_CELLULAR_HEXOSE_TRANSPORT": "Cellular hexose transport", "REACTOME_CDC42_GTPASE_CYCLE": "CDC42 GTPase cycle", "REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS": "Cellular response to chemical stress", "REACTOME_CELLULAR_RESPONSES_TO_STIMULI": "Cellular responses to stimuli", "REACTOME_CELLULAR_RESPONSE_TO_MITOCHONDRIAL_STRESS": "Cellular response to mitochondrial stress", "REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS": "Cellular response to heat stress", "REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA": "Cellular response to hypoxia", "REACTOME_CELLULAR_RESPONSE_TO_STARVATION": "Cellular response to starvation", "REACTOME_CELLULAR_SENESCENCE": "Cellular Senescence", "REACTOME_CELL_CELL_JUNCTION_ORGANIZATION": "Cell-cell junction organization", "REACTOME_CELL_CELL_COMMUNICATION": "Cell-Cell communication", "REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS": "Cell-extracellular matrix interactions", "REACTOME_CELL_CYCLE": "Cell Cycle", "REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE": "Cell death signalling via NRAGE, NRIF and NADE", "REACTOME_CGMP_EFFECTS": "cGMP effects", "REACTOME_CHAPERONE_MEDIATED_AUTOPHAGY": "Chaperone Mediated Autophagy", "REACTOME_CELL_CYCLE_CHECKPOINTS": "Cell Cycle Checkpoints", "REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES": "Chemokine receptors bind chemokines", "REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL": "Cell surface interactions at the vascular wall", "REACTOME_CELL_JUNCTION_ORGANIZATION": "Cell junction organization", "REACTOME_CELL_CYCLE_MITOTIC": "Cell Cycle, Mitotic", "REACTOME_CHK1_CHK2_CDS1_MEDIATED_INACTIVATION_OF_CYCLIN_B_CDK1_COMPLEX": "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "REACTOME_CHOLESTEROL_BIOSYNTHESIS": "Cholesterol biosynthesis", "REACTOME_CHL1_INTERACTIONS": "CHL1 interactions", "REACTOME_CHOLINE_CATABOLISM": "Choline catabolism", "REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS": "", "REACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION": "ChREBP activates metabolic gene expression", "REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM": "Chondroitin sulfate/dermatan sulfate metabolism", "REACTOME_CHROMATIN_MODIFYING_ENZYMES": "", "REACTOME_CHROMATIN_MODIFICATIONS_DURING_THE_MATERNAL_TO_ZYGOTIC_TRANSITION_MZT": "Chromatin modifications during the maternal to zygotic transition (MZT)", "REACTOME_CHYLOMICRON_ASSEMBLY": "Chylomicron assembly", "REACTOME_CHYLOMICRON_CLEARANCE": "Chylomicron clearance", "REACTOME_CHYLOMICRON_REMODELING": "Chylomicron remodeling", "REACTOME_CHROMOSOME_MAINTENANCE": "Chromosome Maintenance", "REACTOME_CIPROFLOXACIN_ADME": "Ciprofloxacin ADME", "REACTOME_CILIUM_ASSEMBLY": "Cilium Assembly", "REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE": "Citric acid cycle (TCA cycle)", "REACTOME_CIRCADIAN_CLOCK": "Circadian clock", "REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS": "Class B/2 (Secretin family receptors)", "REACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT": "Class I peroxisomal membrane protein import", "REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS": "Class C/3 (Metabotropic glutamate/pheromone receptors)", "REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS": "Class A/1 (Rhodopsin-like receptors)", "REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION": "CLEC7A (Dectin-1) induces NFAT activation", "REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS": "Clathrin-mediated endocytosis", "REACTOME_CLEC7A_DECTIN_1_SIGNALING": "CLEC7A (Dectin-1) signaling", "REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION": "Class I MHC mediated antigen processing & presentation", "REACTOME_CLEC7A_INFLAMMASOME_PATHWAY": "CLEC7A/inflammasome pathway", "REACTOME_COBALAMIN_CBL_METABOLISM": "Cobalamin (Cbl) metabolism", "REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM": "Cobalamin (Cbl, vitamin B12) transport and metabolism", "REACTOME_COENZYME_A_BIOSYNTHESIS": "Coenzyme A biosynthesis", "REACTOME_COHESIN_LOADING_ONTO_CHROMATIN": "Cohesin Loading onto Chromatin", "REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES": "Collagen biosynthesis and modifying enzymes", "REACTOME_COLLAGEN_DEGRADATION": "Collagen degradation", "REACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION": "Common Pathway of Fibrin Clot Formation", "REACTOME_COLLAGEN_FORMATION": "Collagen formation", "REACTOME_COMPLEX_III_ASSEMBLY": "Complex III assembly", "REACTOME_COLLAGEN_CHAIN_TRIMERIZATION": "Collagen chain trimerization", "REACTOME_COMPLEX_I_BIOGENESIS": "Complex I biogenesis", "REACTOME_CONDENSATION_OF_PROMETAPHASE_CHROMOSOMES": "Condensation of Prometaphase Chromosomes", "REACTOME_COMPLEMENT_CASCADE": "Complement cascade", "REACTOME_COMPLEX_IV_ASSEMBLY": "Complex IV assembly", "REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES": "Condensation of Prophase Chromosomes", "REACTOME_CONJUGATION_OF_BENZOATE_WITH_GLYCINE": "Conjugation of benzoate with glycine", "REACTOME_CONSTITUTIVE_SIGNALING_BY_LIGAND_RESPONSIVE_EGFR_CANCER_VARIANTS": "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "REACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER": "Constitutive Signaling by AKT1 E17K in Cancer", "REACTOME_CONSTITUTIVE_SIGNALING_BY_EGFRVIII": "Constitutive Signaling by EGFRvIII", "REACTOME_CONSTITUTIVE_SIGNALING_BY_ABERRANT_PI3K_IN_CANCER": "Constitutive Signaling by Aberrant PI3K in Cancer", "REACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2": "Constitutive Signaling by Overexpressed ERBB2", "REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "REACTOME_COOPERATION_OF_PREFOLDIN_AND_TRIC_CCT_IN_ACTIN_AND_TUBULIN_FOLDING": "Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding", "REACTOME_COOPERATION_OF_PDCL_PHLP1_AND_TRIC_CCT_IN_G_PROTEIN_BETA_FOLDING": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "REACTOME_COPII_MEDIATED_VESICLE_TRANSPORT": "COPII-mediated vesicle transport", "REACTOME_COPI_DEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC": "COPI-dependent Golgi-to-ER retrograde traffic", "REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY": "", "REACTOME_CREATINE_METABOLISM": "Creatine metabolism", "REACTOME_COPI_INDEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC": "COPI-independent Golgi-to-ER retrograde traffic", "REACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT": "COPI-mediated anterograde transport", "REACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE": "CREB1 phosphorylation through the activation of Adenylate Cyclase", "REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS": "Creation of C4 and C2 activators", "REACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII_CAMKK_CAMKIV_CASCASDE": "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING": "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "REACTOME_CREB3_FACTORS_ACTIVATE_GENES": "CREB3 factors activate genes", "REACTOME_CREB_PHOSPHORYLATION": "CREB phosphorylation", "REACTOME_CRMPS_IN_SEMA3A_SIGNALING": "CRMPs in Sema3A signaling", "REACTOME_CRISTAE_FORMATION": "Cristae formation", "REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS": "Crosslinking of collagen fibrils", "REACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES": "Cross-presentation of particulate exogenous antigens (phagosomes)", "REACTOME_CS_DS_DEGRADATION": "CS/DS degradation", "REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES": "Cross-presentation of soluble exogenous antigens (endosomes)", "REACTOME_CTLA4_INHIBITORY_SIGNALING": "", "REACTOME_CYCLIN_A_CDK2_ASSOCIATED_EVENTS_AT_S_PHASE_ENTRY": "Cyclin A:Cdk2-associated events at S phase entry", "REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION": "Cyclin A/B1/B2 associated events during G2/M transition", "REACTOME_CYP2E1_REACTIONS": "CYP2E1 reactions", "REACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1": "Cyclin D associated events in G1", "REACTOME_CYTOCHROME_C_MEDIATED_APOPTOTIC_RESPONSE": "Cytochrome c-mediated apoptotic response", "REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE": "Cytochrome P450 - arranged by substrate type", "REACTOME_CYTOSOLIC_IRON_SULFUR_CLUSTER_ASSEMBLY": "Cytosolic iron-sulfur cluster assembly", "REACTOME_CYTOPROTECTION_BY_HMOX1": "Cytoprotection by HMOX1", "REACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA": "Cytosolic sensors of pathogen-associated DNA", "REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION": "Cytosolic tRNA aminoacylation", "REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES": "Cytosolic sulfonation of small molecules", "REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM": "Cytokine Signaling in Immune system", "REACTOME_DAG_AND_IP3_SIGNALING": "DAG and IP3 signaling", "REACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS": "C-type lectin receptors (CLRs)", "REACTOME_DAP12_INTERACTIONS": "DAP12 interactions", "REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING": "DCC mediated attractive signaling", "REACTOME_DARPP_32_EVENTS": "DARPP-32 events", "REACTOME_DAP12_SIGNALING": "DAP12 signaling", "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA": "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX": "Deactivation of the beta-catenin transactivating complex", "REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY": "Deadenylation-dependent mRNA decay", "REACTOME_DEADENYLATION_OF_MRNA": "Deadenylation of mRNA", "REACTOME_DECTIN_1_MEDIATED_NONCANONICAL_NF_KB_SIGNALING": "Dectin-1 mediated noncanonical NF-kB signaling", "REACTOME_DEFECTIVE_B4GALT7_CAUSES_EDS_PROGEROID_TYPE": "Defective B4GALT7 causes EDS, progeroid type", "REACTOME_DEATH_RECEPTOR_SIGNALING": "Death Receptor Signaling", "REACTOME_DEFECTIVE_B4GALT1_CAUSES_B4GALT1_CDG_CDG_2D": "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "REACTOME_DECTIN_2_FAMILY": "Dectin-2 family", "REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS": "Defective C1GALT1C1 causes TNPS", "REACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE": "Defective CHST14 causes EDS, musculocontractural type", "REACTOME_DEFECTIVE_CFTR_CAUSES_CYSTIC_FIBROSIS": "", "REACTOME_DEFECTIVE_CHST3_CAUSES_SEDCJD": "Defective CHST3 causes SEDCJD", "REACTOME_DEFECTIVE_CHST6_CAUSES_MCDC1": "Defective CHST6 causes MCDC1", "REACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS": "Defective CHSY1 causes TPBS", "REACTOME_DEFECTIVE_CSF2RB_CAUSES_SMDP5": "Defective CSF2RB causes SMDP5", "REACTOME_DEFECTIVE_F9_ACTIVATION": "Defective F9 activation", "REACTOME_DEFECTIVE_EXT2_CAUSES_EXOSTOSES_2": "Defective EXT2 causes exostoses 2", "REACTOME_DEFECTIVE_FACTOR_IX_CAUSES_HEMOPHILIA_B": "Defective factor IX causes hemophilia B", "REACTOME_DEFECTIVE_FACTOR_VIII_CAUSES_HEMOPHILIA_A": "Defective factor VIII causes hemophilia A", "REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC": "Defective GALNT3 causes HFTC", "REACTOME_DEFECTIVE_INTRINSIC_PATHWAY_FOR_APOPTOSIS": "Defective Intrinsic Pathway for Apoptosis", "REACTOME_DEFECTIVE_RIPK1_MEDIATED_REGULATED_NECROSIS": "Defective RIPK1-mediated regulated necrosis", "REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3": "Defective LFNG causes SCDO3", "REACTOME_DEFECTIVE_ST3GAL3_CAUSES_MCT12_AND_EIEE15": "Defective ST3GAL3 causes MCT12 and EIEE15", "REACTOME_DEFECTS_IN_BIOTIN_BTN_METABOLISM": "Defects in biotin (Btn) metabolism", "REACTOME_DEFECTS_IN_VITAMIN_AND_COFACTOR_METABOLISM": "Defects in vitamin and cofactor metabolism", "REACTOME_DEFECTS_IN_COBALAMIN_B12_METABOLISM": "Defects in cobalamin (B12) metabolism", "REACTOME_DEFECTS_OF_CONTACT_ACTIVATION_SYSTEM_CAS_AND_KALLIKREIN_KININ_SYSTEM_KKS": "Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)", "REACTOME_DEFECTS_OF_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN": "Defects of platelet adhesion to exposed collagen", "REACTOME_DEGRADATION_OF_CYSTEINE_AND_HOMOCYSTEINE": "Degradation of cysteine and homocysteine", "REACTOME_DEGRADATION_OF_AXIN": "Degradation of AXIN", "REACTOME_DEFENSINS": "Defensins", "REACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX": "Degradation of beta-catenin by the destruction complex", "REACTOME_DEGRADATION_OF_DVL": "Degradation of DVL", "REACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA": "Depolymerization of the Nuclear Lamina", "REACTOME_DEGRADATION_OF_GLI1_BY_THE_PROTEASOME": "Degradation of GLI1 by the proteasome", "REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS": "", "REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX": "Degradation of the extracellular matrix", "REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE": "Deposition of new CENPA-containing nucleosomes at the centromere", "REACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION": "DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "REACTOME_DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES": "Detoxification of Reactive Oxygen Species", "REACTOME_DIGESTION": "Digestion", "REACTOME_DIFFERENTIATION_OF_KERATINOCYTES_IN_INTERFOLLICULAR_EPIDERMIS_IN_MAMMALIAN_SKIN": "Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin", "REACTOME_DEUBIQUITINATION": "Deubiquitination", "REACTOME_DIGESTION_OF_DIETARY_LIPID": "Digestion of dietary lipid", "REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE": "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE": "Digestion of dietary carbohydrate", "REACTOME_DIGESTION_AND_ABSORPTION": "Digestion and absorption", "REACTOME_DEVELOPMENTAL_BIOLOGY": "Developmental Biology", "REACTOME_DISEASES_ASSOCIATED_WITH_GLYCOSYLATION_PRECURSOR_BIOSYNTHESIS": "Diseases associated with glycosylation precursor biosynthesis", "REACTOME_DISEASES_ASSOCIATED_WITH_N_GLYCOSYLATION_OF_PROTEINS": "Diseases associated with N-glycosylation of proteins", "REACTOME_DISEASES_ASSOCIATED_WITH_GLYCOSAMINOGLYCAN_METABOLISM": "Diseases associated with glycosaminoglycan metabolism", "REACTOME_DISEASES_ASSOCIATED_WITH_SURFACTANT_METABOLISM": "Diseases associated with surfactant metabolism", "REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS": "Diseases associated with O-glycosylation of proteins", "REACTOME_DISEASES_OF_BASE_EXCISION_REPAIR": "Diseases of Base Excision Repair", "REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM": "Diseases of carbohydrate metabolism", "REACTOME_DISEASES_OF_HEMOSTASIS": "Diseases of hemostasis", "REACTOME_DISEASES_OF_DNA_REPAIR": "Diseases of DNA repair", "REACTOME_DISEASES_OF_IMMUNE_SYSTEM": "Diseases of Immune System", "REACTOME_DISEASES_OF_MISMATCH_REPAIR_MMR": "Diseases of Mismatch Repair (MMR)", "REACTOME_DISEASES_OF_GLYCOSYLATION": "Diseases of glycosylation", "REACTOME_DISEASES_OF_MITOTIC_CELL_CYCLE": "Diseases of mitotic cell cycle", "REACTOME_DISEASES_OF_METABOLISM": "Diseases of metabolism", "REACTOME_DISEASES_OF_PROGRAMMED_CELL_DEATH": "Diseases of programmed cell death", "REACTOME_DISINHIBITION_OF_SNARE_FORMATION": "Disinhibition of SNARE formation", "REACTOME_DISSOLUTION_OF_FIBRIN_CLOT": "Dissolution of Fibrin Clot", "REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS": "Diseases of signal transduction by growth factor receptors and second messengers", "REACTOME_DISPLACEMENT_OF_DNA_GLYCOSYLASE_BY_APEX1": "Displacement of DNA glycosylase by APEX1", "REACTOME_DNA_DAMAGE_BYPASS": "DNA Damage Bypass", "REACTOME_DNA_DAMAGE_REVERSAL": "DNA Damage Reversal", "REACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER": "DNA Damage Recognition in GG-NER", "REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE": "DNA Damage/Telomere Stress Induced Senescence", "REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS": "Disorders of transmembrane transporters", "REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE": "DNA Double Strand Break Response", "REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR": "DNA Double-Strand Break Repair", "REACTOME_DNA_REPLICATION_INITIATION": "DNA replication initiation", "REACTOME_DNA_METHYLATION": "DNA methylation", "REACTOME_DNA_REPAIR": "DNA Repair", "REACTOME_DNA_REPLICATION": "DNA Replication", "REACTOME_DOPAMINE_CLEARANCE_FROM_THE_SYNAPTIC_CLEFT": "Dopamine clearance from the synaptic cleft", "REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE": "Dopamine Neurotransmitter Release Cycle", "REACTOME_DNA_REPLICATION_PRE_INITIATION": "DNA Replication Pre-Initiation", "REACTOME_DNA_STRAND_ELONGATION": "DNA strand elongation", "REACTOME_DOPAMINE_RECEPTORS": "Dopamine receptors", "REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING": "Downregulation of ERBB4 signaling", "REACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING": "Downregulation of ERBB2 signaling", "REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING": "Downregulation of ERBB2:ERBB3 signaling", "REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY": "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR2": "Downstream signaling of activated FGFR2", "REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING": "Downregulation of TGF-beta receptor signaling", "REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR1": "Downstream signaling of activated FGFR1", "REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3": "Downstream signaling of activated FGFR3", "REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR4": "Downstream signaling of activated FGFR4", "REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR": "Downstream signaling events of B Cell Receptor (BCR)", "REACTOME_DRUG_MEDIATED_INHIBITION_OF_CDK4_CDK6_ACTIVITY": "Drug-mediated inhibition of CDK4/CDK6 activity", "REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION": "Downstream signal transduction", "REACTOME_DRUG_ADME": "Drug ADME", "REACTOME_DUAL_INCISION_IN_TC_NER": "Dual incision in TC-NER", "REACTOME_DUAL_INCISION_IN_GG_NER": "Dual Incision in GG-NER", "REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION": "E2F mediated regulation of DNA replication", "REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE": "Early Phase of HIV Life Cycle", "REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION": "E2F-enabled inhibition of pre-replication complex formation", "REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS": "E3 ubiquitin ligases ubiquitinate target proteins", "REACTOME_EARLY_SARS_COV_2_INFECTION_EVENTS": "Early SARS-CoV-2 Infection Events", "REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS": "Effects of PIP2 hydrolysis", "REACTOME_ECM_PROTEOGLYCANS": "ECM proteoglycans", "REACTOME_EGFR_DOWNREGULATION": "EGFR downregulation", "REACTOME_EGFR_INTERACTS_WITH_PHOSPHOLIPASE_C_GAMMA": "EGFR interacts with phospholipase C-gamma", "REACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN": "EGFR Transactivation by Gastrin", "REACTOME_EICOSANOIDS": "Eicosanoids", "REACTOME_EGR2_AND_SOX10_MEDIATED_INITIATION_OF_SCHWANN_CELL_MYELINATION": "EGR2 and SOX10-mediated initiation of Schwann cell myelination", "REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS": "Eicosanoid ligand-binding receptors", "REACTOME_ELASTIC_FIBRE_FORMATION": "Elastic fibre formation", "REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS": "Elevation of cytosolic Ca2+ levels", "REACTOME_ENDOGENOUS_STEROLS": "Endogenous sterols", "REACTOME_ELECTRIC_TRANSMISSION_ACROSS_GAP_JUNCTIONS": "Electric Transmission Across Gap Junctions", "REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT": "Endosomal Sorting Complex Required For Transport (ESCRT)", "REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY": "Endosomal/Vacuolar pathway", "REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK": "Energy dependent regulation of mTOR by LKB1-AMPK", "REACTOME_ENOS_ACTIVATION": "eNOS activation", "REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE": "EPHA-mediated growth cone collapse", "REACTOME_ENHANCED_BINDING_OF_GP1BA_VARIANT_TO_VWF_MULTIMER_COLLAGEN": "Enhanced binding of GP1BA variant to VWF multimer:collagen", "REACTOME_EPHRIN_SIGNALING": "Ephrin signaling", "REACTOME_EPHB_MEDIATED_FORWARD_SIGNALING": "EPHB-mediated forward signaling", "REACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS": "EPH-ephrin mediated repulsion of cells", "REACTOME_EPITHELIAL_MESENCHYMAL_TRANSITION_EMT_DURING_GASTRULATION": "Epithelial-Mesenchymal Transition (EMT) during gastrulation", "REACTOME_EPH_EPHRIN_SIGNALING": "EPH-Ephrin signaling", "REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING": "ERBB2 Activates PTK6 Signaling", "REACTOME_ERBB2_REGULATES_CELL_MOTILITY": "ERBB2 Regulates Cell Motility", "REACTOME_ERKS_ARE_INACTIVATED": "ERKs are inactivated", "REACTOME_ERK_MAPK_TARGETS": "ERK/MAPK targets", "REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION": "Epigenetic regulation of gene expression", "REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION": "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "REACTOME_ERYTHROCYTES_TAKE_UP_CARBON_DIOXIDE_AND_RELEASE_OXYGEN": "Erythrocytes take up carbon dioxide and release oxygen", "REACTOME_ERYTHROCYTES_TAKE_UP_OXYGEN_AND_RELEASE_CARBON_DIOXIDE": "Erythrocytes take up oxygen and release carbon dioxide", "REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K": "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOLIPASE_C_GAMMA_PLCG": "Erythropoietin activates Phospholipase C gamma (PLCG)", "REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5": "Erythropoietin activates STAT5", "REACTOME_ERYTHROPOIETIN_ACTIVATES_RAS": "Erythropoietin activates RAS", "REACTOME_ER_QUALITY_CONTROL_COMPARTMENT_ERQC": "ER Quality Control Compartment (ERQC)", "REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION": "Establishment of Sister Chromatid Cohesion", "REACTOME_ESTROGEN_BIOSYNTHESIS": "Estrogen biosynthesis", "REACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT": "ER to Golgi Anterograde Transport", "REACTOME_ESR_MEDIATED_SIGNALING": "ESR-mediated signaling", "REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION": "Estrogen-dependent gene expression", "REACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ": "Estrogen-stimulated signaling through PRKCZ", "REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING": "Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "REACTOME_ETHANOL_OXIDATION": "Ethanol oxidation", "REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION": "Eukaryotic Translation Elongation", "REACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES": "Evasion by RSV of host interferon responses", "REACTOME_EUKARYOTIC_TRANSLATION_INITIATION": "Eukaryotic Translation Initiation", "REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS": "Export of Viral Ribonucleoproteins from Nucleus", "REACTOME_EXTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION": "Extrinsic Pathway of Fibrin Clot Formation", "REACTOME_EXTENSION_OF_TELOMERES": "Extension of Telomeres", "REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING": "Extra-nuclear estrogen signaling", "REACTOME_FASL_CD95L_SIGNALING": "FasL/ CD95L signaling", "REACTOME_FASTK_FAMILY_PROTEINS_REGULATE_PROCESSING_AND_STABILITY_OF_MITOCHONDRIAL_RNAS": "FASTK family proteins regulate processing and stability of mitochondrial RNAs", "REACTOME_FANCONI_ANEMIA_PATHWAY": "Fanconi Anemia Pathway", "REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION": "Extracellular matrix organization", "REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION": "Factors involved in megakaryocyte development and platelet production", "REACTOME_FATTY_ACIDS": "Fatty acids", "REACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "REACTOME_FBXW7_MUTANTS_AND_NOTCH1_IN_CANCER": "FBXW7 Mutants and NOTCH1 in Cancer", "REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS": "Fatty acyl-CoA biosynthesis", "REACTOME_FATTY_ACID_METABOLISM": "Fatty acid metabolism", "REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION": "FCERI mediated Ca+2 mobilization", "REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION": "FCERI mediated MAPK activation", "REACTOME_FCGR_ACTIVATION": "FCGR activation", "REACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION": "FCERI mediated NF-kB activation", "REACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS": "FCGR3A-mediated IL10 synthesis", "REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS": "Fcgamma receptor (FCGR) dependent phagocytosis", "REACTOME_FERTILIZATION": "Fertilization", "REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING": "Fc epsilon receptor (FCERI) signaling", "REACTOME_FGFR1C_LIGAND_BINDING_AND_ACTIVATION": "FGFR1c ligand binding and activation", "REACTOME_FGFR1B_LIGAND_BINDING_AND_ACTIVATION": "FGFR1b ligand binding and activation", "REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION": "FGFR1 ligand binding and activation", "REACTOME_FGFR1_MUTANT_RECEPTOR_ACTIVATION": "FGFR1 mutant receptor activation", "REACTOME_FGFR2B_LIGAND_BINDING_AND_ACTIVATION": "FGFR2b ligand binding and activation", "REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION": "FGFR2c ligand binding and activation", "REACTOME_FGFR2_ALTERNATIVE_SPLICING": "FGFR2 alternative splicing", "REACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION": "FGFR2 ligand binding and activation", "REACTOME_FGFR2_MUTANT_RECEPTOR_ACTIVATION": "FGFR2 mutant receptor activation", "REACTOME_FGFRL1_MODULATION_OF_FGFR1_SIGNALING": "FGFRL1 modulation of FGFR1 signaling", "REACTOME_FGFR3B_LIGAND_BINDING_AND_ACTIVATION": "FGFR3b ligand binding and activation", "REACTOME_FGFR3_LIGAND_BINDING_AND_ACTIVATION": "FGFR3 ligand binding and activation", "REACTOME_FIBRONECTIN_MATRIX_FORMATION": "Fibronectin matrix formation", "REACTOME_FICOLINS_BIND_TO_REPETITIVE_CARBOHYDRATE_STRUCTURES_ON_THE_TARGET_CELL_SURFACE": "Ficolins bind to repetitive carbohydrate structures on the target cell surface", "REACTOME_FLT3_SIGNALING_BY_CBL_MUTANTS": "FLT3 signaling by CBL mutants", "REACTOME_FLT3_SIGNALING_THROUGH_SRC_FAMILY_KINASES": "FLT3 signaling through SRC family kinases", "REACTOME_FOLDING_OF_ACTIN_BY_CCT_TRIC": "Folding of actin by CCT/TriC", "REACTOME_FLT3_SIGNALING_IN_DISEASE": "FLT3 signaling in disease", "REACTOME_FLT3_SIGNALING": "FLT3 Signaling", "REACTOME_FORMATION_OF_APOPTOSOME": "Formation of apoptosome", "REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING": "Formation of ATP by chemiosmotic coupling", "REACTOME_FORMATION_OF_AXIAL_MESODERM": "Formation of axial mesoderm", "REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM": "Formation of definitive endoderm", "REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE": "Formation of Fibrin Clot (Clotting Cascade)", "REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM": "Formation of lateral plate mesoderm", "REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER": "Formation of Incision Complex in GG-NER", "REACTOME_FORMATION_OF_INTERMEDIATE_MESODERM": "Formation of intermediate mesoderm", "REACTOME_FORMATION_OF_SENESCENCE_ASSOCIATED_HETEROCHROMATIN_FOCI_SAHF": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "REACTOME_FORMATION_OF_PARAXIAL_MESODERM": "Formation of paraxial mesoderm", "REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX": "Formation of RNA Pol II elongation complex", "REACTOME_FORMATION_OF_THE_ANTERIOR_NEURAL_PLATE": "Formation of the anterior neural plate", "REACTOME_FORMATION_OF_TC_NER_PRE_INCISION_COMPLEX": "Formation of TC-NER Pre-Incision Complex", "REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX": "Formation of the beta-catenin:TCF transactivating complex", "REACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX": "Formation of the Early Elongation Complex", "REACTOME_FORMATION_OF_THE_NEPHRIC_DUCT": "Formation of the nephric duct", "REACTOME_FORMATION_OF_THE_POSTERIOR_NEURAL_PLATE": "Formation of the posterior neural plate", "REACTOME_FORMATION_OF_THE_URETERIC_BUD": "Formation of the ureteric bud", "REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE": "Formation of the cornified envelope", "REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC": "Formation of tubulin folding intermediates by CCT/TriC", "REACTOME_FORMATION_OF_XYLULOSE_5_PHOSPHATE": "Formation of xylulose-5-phosphate", "REACTOME_FORMYL_PEPTIDE_RECEPTORS_BIND_FORMYL_PEPTIDES_AND_MANY_OTHER_LIGANDS": "Formyl peptide receptors bind formyl peptides and many other ligands", "REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES": "Formation of WDR5-containing histone-modifying complexes", "REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES": "FOXO-mediated transcription of cell cycle genes", "REACTOME_FOXO_MEDIATED_TRANSCRIPTION": "FOXO-mediated transcription", "REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES": "FOXO-mediated transcription of cell death genes", "REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION": "Free fatty acids regulate insulin secretion", "REACTOME_FREE_FATTY_ACID_RECEPTORS": "Free fatty acid receptors", "REACTOME_FRS_MEDIATED_FGFR2_SIGNALING": "FRS-mediated FGFR2 signaling", "REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES": "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "REACTOME_FRS_MEDIATED_FGFR1_SIGNALING": "FRS-mediated FGFR1 signaling", "REACTOME_FRS_MEDIATED_FGFR3_SIGNALING": "FRS-mediated FGFR3 signaling", "REACTOME_FRS_MEDIATED_FGFR4_SIGNALING": "FRS-mediated FGFR4 signaling", "REACTOME_FRUCTOSE_CATABOLISM": "Fructose catabolism", "REACTOME_FRUCTOSE_METABOLISM": "Fructose metabolism", "REACTOME_G0_AND_EARLY_G1": "G0 and Early G1", "REACTOME_G1_S_SPECIFIC_TRANSCRIPTION": "G1/S-Specific Transcription", "REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT": "G2/M DNA damage checkpoint", "REACTOME_GAB1_SIGNALOSOME": "GAB1 signalosome", "REACTOME_G1_S_DNA_DAMAGE_CHECKPOINTS": "G1/S DNA Damage Checkpoints", "REACTOME_G2_PHASE": "G2 Phase", "REACTOME_G2_M_DNA_REPLICATION_CHECKPOINT": "G2/M DNA replication checkpoint", "REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION": "GABA synthesis, release, reuptake and degradation", "REACTOME_G2_M_CHECKPOINTS": "G2/M Checkpoints", "REACTOME_GABA_B_RECEPTOR_ACTIVATION": "GABA B receptor activation", "REACTOME_GABA_RECEPTOR_ACTIVATION": "GABA receptor activation", "REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS": "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins", "REACTOME_GAMMA_CARBOXYLATION_HYPUSINYLATION_HYDROXYLATION_AND_ARYLSULFATASE_ACTIVATION": "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "REACTOME_GAP_FILLING_DNA_REPAIR_SYNTHESIS_AND_LIGATION_IN_GG_NER": "Gap-filling DNA repair synthesis and ligation in GG-NER", "REACTOME_GAP_JUNCTION_DEGRADATION": "Gap junction degradation", "REACTOME_GAP_JUNCTION_ASSEMBLY": "Gap junction assembly", "REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK": "Gastrin-CREB signalling pathway via PKC and MAPK", "REACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION": "Gap junction trafficking and regulation", "REACTOME_GDP_FUCOSE_BIOSYNTHESIS": "GDP-fucose biosynthesis", "REACTOME_GASTRULATION": "Gastrulation", "REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES": "Generation of second messenger molecules", "REACTOME_GENE_AND_PROTEIN_EXPRESSION_BY_JAK_STAT_SIGNALING_AFTER_INTERLEUKIN_12_STIMULATION": "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION": "Germ layer formation at gastrulation", "REACTOME_GENE_SILENCING_BY_RNA": "Gene Silencing by RNA", "REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION": "GLI proteins bind promoters of Hh responsive genes to promote transcription", "REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER": "Global Genome Nucleotide Excision Repair (GG-NER)", "REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION": "Glucagon signaling in metabolic regulation", "REACTOME_GLUCOCORTICOID_BIOSYNTHESIS": "Glucocorticoid biosynthesis", "REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS": "Glucagon-type ligand receptors", "REACTOME_GLUCONEOGENESIS": "Gluconeogenesis", "REACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM": "Glutamate and glutamine metabolism", "REACTOME_GLUCOSE_METABOLISM": "Glucose metabolism", "REACTOME_GLUCURONIDATION": "Glucuronidation", "REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE": "Glutamate Neurotransmitter Release Cycle", "REACTOME_GLYCEROPHOSPHOLIPID_CATABOLISM": "Glycerophospholipid catabolism", "REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS": "Glycogen breakdown (glycogenolysis)", "REACTOME_GLYCINE_DEGRADATION": "Glycine degradation", "REACTOME_GLUTATHIONE_CONJUGATION": "Glutathione conjugation", "REACTOME_GLUTATHIONE_SYNTHESIS_AND_RECYCLING": "Glutathione synthesis and recycling", "REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS": "Glycerophospholipid biosynthesis", "REACTOME_GLYCOGEN_METABOLISM": "Glycogen metabolism", "REACTOME_GLYCOGEN_STORAGE_DISEASES": "Glycogen storage diseases", "REACTOME_GLYCOGEN_SYNTHESIS": "Glycogen synthesis", "REACTOME_GLYCOSPHINGOLIPID_BIOSYNTHESIS": "Glycosphingolipid biosynthesis", "REACTOME_GLYCOSAMINOGLYCAN_METABOLISM": "Glycosaminoglycan metabolism", "REACTOME_GLYOXYLATE_METABOLISM_AND_GLYCINE_DEGRADATION": "Glyoxylate metabolism and glycine degradation", "REACTOME_GLYCOSPHINGOLIPID_METABOLISM": "Glycosphingolipid metabolism", "REACTOME_GLYCOSPHINGOLIPID_TRANSPORT": "Glycosphingolipid transport", "REACTOME_GLYCOSPHINGOLIPID_CATABOLISM": "Glycosphingolipid catabolism", "REACTOME_GOLGI_CISTERNAE_PERICENTRIOLAR_STACK_REORGANIZATION": "Golgi Cisternae Pericentriolar Stack Reorganization", "REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING": "GP1b-IX-V activation signalling", "REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS": "Golgi Associated Vesicle Biogenesis", "REACTOME_GOLGI_TO_ER_RETROGRADE_TRANSPORT": "Golgi-to-ER retrograde transport", "REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING": "GRB2 events in ERBB2 signaling", "REACTOME_GPER1_SIGNALING": "GPER1 signaling", "REACTOME_GRB7_EVENTS_IN_ERBB2_SIGNALING": "GRB7 events in ERBB2 signaling", "REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS": "GRB2:SOS provides linkage to MAPK signaling for Integrins", "REACTOME_GPCR_LIGAND_BINDING": "GPCR ligand binding", "REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS": "G alpha (12/13) signalling events", "REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING": "Growth hormone receptor signaling", "REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE": "GPVI-mediated activation cascade", "REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS": "G alpha (q) signalling events", "REACTOME_G_ALPHA_I_SIGNALLING_EVENTS": "G alpha (i) signalling events", "REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS": "G alpha (z) signalling events", "REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA": "G beta:gamma signalling through PI3Kgamma", "REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_CDC42": "G beta:gamma signalling through CDC42", "REACTOME_G_ALPHA_S_SIGNALLING_EVENTS": "G alpha (s) signalling events", "REACTOME_G_PROTEIN_ACTIVATION": "G-protein activation", "REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING": "G-protein beta:gamma signalling", "REACTOME_G_PROTEIN_MEDIATED_EVENTS": "G-protein mediated events", "REACTOME_HATS_ACETYLATE_HISTONES": "HATs acetylate histones", "REACTOME_HCMV_EARLY_EVENTS": "HCMV Early Events", "REACTOME_HDL_ASSEMBLY": "HDL assembly", "REACTOME_HDL_CLEARANCE": "HDL clearance", "REACTOME_HDACS_DEACETYLATE_HISTONES": "HDACs deacetylate histones", "REACTOME_HCMV_LATE_EVENTS": "HCMV Late Events", "REACTOME_HCMV_INFECTION": "HCMV Infection", "REACTOME_HDL_REMODELING": "HDL remodeling", "REACTOME_HDR_THROUGH_MMEJ_ALT_NHEJ": "HDR through MMEJ (alt-NHEJ)", "REACTOME_HDMS_DEMETHYLATE_HISTONES": "HDMs demethylate histones", "REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR": "HDR through Homologous Recombination (HRR)", "REACTOME_HEME_DEGRADATION": "Heme degradation", "REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA": "HDR through Single Strand Annealing (SSA)", "REACTOME_HEME_BIOSYNTHESIS": "Heme biosynthesis", "REACTOME_HEDGEHOG_OFF_STATE": "Hedgehog 'off' state", "REACTOME_HEDGEHOG_LIGAND_BIOGENESIS": "Hedgehog ligand biogenesis", "REACTOME_HEDGEHOG_ON_STATE": "Hedgehog 'on' state", "REACTOME_HEME_SIGNALING": "Heme signaling", "REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS": "Highly calcium permeable nicotinic acetylcholine receptors", "REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM": "Heparan sulfate/heparin (HS-GAG) metabolism", "REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS": "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "REACTOME_HIGHLY_SODIUM_PERMEABLE_POSTSYNAPTIC_ACETYLCHOLINE_NICOTINIC_RECEPTORS": "Highly sodium permeable postsynaptic acetylcholine nicotinic receptors", "REACTOME_HISTIDINE_CATABOLISM": "Histidine catabolism", "REACTOME_HEMOSTASIS": "Hemostasis", "REACTOME_HIV_ELONGATION_ARREST_AND_RECOVERY": "HIV elongation arrest and recovery", "REACTOME_HIV_INFECTION": "HIV Infection", "REACTOME_HIV_LIFE_CYCLE": "HIV Life Cycle", "REACTOME_HIV_TRANSCRIPTION_INITIATION": "HIV Transcription Initiation", "REACTOME_HIV_TRANSCRIPTION_ELONGATION": "HIV Transcription Elongation", "REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE": "Homologous DNA Pairing and Strand Exchange", "REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS": "Hormone ligand-binding receptors", "REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS": "Host Interactions of HIV factors", "REACTOME_HOMOLOGY_DIRECTED_REPAIR": "Homology Directed Repair", "REACTOME_HSF1_ACTIVATION": "HSF1 activation", "REACTOME_HSF1_DEPENDENT_TRANSACTIVATION": "HSF1-dependent transactivation", "REACTOME_HS_GAG_BIOSYNTHESIS": "HS-GAG biosynthesis", "REACTOME_HUR_ELAVL1_BINDS_AND_STABILIZES_MRNA": "HuR (ELAVL1) binds and stabilizes mRNA", "REACTOME_HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "REACTOME_HS_GAG_DEGRADATION": "HS-GAG degradation", "REACTOME_HYALURONAN_METABOLISM": "Hyaluronan metabolism", "REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT": "", "REACTOME_HYDROLYSIS_OF_LPC": "Hydrolysis of LPC", "REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION": "", "REACTOME_IFNG_SIGNALING_ACTIVATES_MAPKS": "IFNG signaling activates MAPKs", "REACTOME_IKBA_VARIANT_LEADS_TO_EDA_ID": "IkBA variant leads to EDA-ID", "REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1": "IKK complex recruitment mediated by RIP1", "REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION": "Incretin synthesis, secretion, and inactivation", "REACTOME_IL_6_TYPE_CYTOKINE_RECEPTOR_LIGAND_INTERACTIONS": "IL-6-type cytokine receptor ligand interactions", "REACTOME_INACTIVATION_OF_CDC42_AND_RAC1": "Inactivation of CDC42 and RAC1", "REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING": "Inactivation of CSF3 (G-CSF) signaling", "REACTOME_INDUCTION_OF_CELL_CELL_FUSION": "Induction of Cell-Cell Fusion", "REACTOME_INFECTION_WITH_MYCOBACTERIUM_TUBERCULOSIS": "Infection with Mycobacterium tuberculosis", "REACTOME_INFLAMMASOMES": "Inflammasomes", "REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1": "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "REACTOME_INFLUENZA_INFECTION": "Influenza Infection", "REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS": "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "REACTOME_INHIBITION_OF_DNA_RECOMBINATION_AT_TELOMERE": "Inhibition of DNA recombination at telomere", "REACTOME_INITIATION_OF_NUCLEAR_ENVELOPE_NE_REFORMATION": "Initiation of Nuclear Envelope (NE) Reformation", "REACTOME_INFECTIOUS_DISEASE": "Infectious disease", "REACTOME_INLA_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELLS": "InlA-mediated entry of Listeria monocytogenes into host cells", "REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT": "Initial triggering of complement", "REACTOME_INLB_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELL": "InlB-mediated entry of Listeria monocytogenes into host cell", "REACTOME_INOSITOL_PHOSPHATE_METABOLISM": "Inositol phosphate metabolism", "REACTOME_INSULIN_PROCESSING": "Insulin processing", "REACTOME_INSERTION_OF_TAIL_ANCHORED_PROTEINS_INTO_THE_ENDOPLASMIC_RETICULUM_MEMBRANE": "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE": "Insulin receptor signalling cascade", "REACTOME_INSULIN_RECEPTOR_RECYCLING": "Insulin receptor recycling", "REACTOME_INTEGRIN_SIGNALING": "Integrin signaling", "REACTOME_INTEGRATION_OF_PROVIRUS": "Integration of provirus", "REACTOME_INNATE_IMMUNE_SYSTEM": "Innate Immune System", "REACTOME_INTEGRATION_OF_ENERGY_METABOLISM": "Integration of energy metabolism", "REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS": "Integrin cell surface interactions", "REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS": "Interactions of Vpr with host cellular proteins", "REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS": "Interactions of Rev with host cellular proteins", "REACTOME_INTERACTION_WITH_CUMULUS_CELLS_AND_THE_ZONA_PELLUCIDA": "Interaction With Cumulus Cells And The Zona Pellucida", "REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS": "Interaction between L1 and Ankyrins", "REACTOME_INTERLEUKIN_12_FAMILY_SIGNALING": "Interleukin-12 family signaling", "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING": "Interferon alpha/beta signaling", "REACTOME_INTERLEUKIN_10_SIGNALING": "Interleukin-10 signaling", "REACTOME_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES": "Interconversion of nucleotide di- and triphosphates", "REACTOME_INTERLEUKIN_15_SIGNALING": "Interleukin-15 signaling", "REACTOME_INTERFERON_GAMMA_SIGNALING": "Interferon gamma signaling", "REACTOME_INTERLEUKIN_12_SIGNALING": "Interleukin-12 signaling", "REACTOME_INTERLEUKIN_17_SIGNALING": "Interleukin-17 signaling", "REACTOME_INTERFERON_SIGNALING": "Interferon Signaling", "REACTOME_INTERLEUKIN_18_SIGNALING": "Interleukin-18 signaling", "REACTOME_INTERLEUKIN_1_PROCESSING": "Interleukin-1 processing", "REACTOME_INTERLEUKIN_1_SIGNALING": "Interleukin-1 signaling", "REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING": "Interleukin-1 family signaling", "REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING": "Interleukin-20 family signaling", "REACTOME_INTERLEUKIN_23_SIGNALING": "Interleukin-23 signaling", "REACTOME_INTERLEUKIN_21_SIGNALING": "Interleukin-21 signaling", "REACTOME_INTERLEUKIN_2_SIGNALING": "Interleukin-2 signaling", "REACTOME_INTERLEUKIN_27_SIGNALING": "Interleukin-27 signaling", "REACTOME_INTERLEUKIN_35_SIGNALLING": "Interleukin-35 Signalling", "REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING": "Interleukin-2 family signaling", "REACTOME_INTERLEUKIN_36_PATHWAY": "Interleukin-36 pathway", "REACTOME_INTERLEUKIN_37_SIGNALING": "Interleukin-37 signaling", "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING": "Interleukin-4 and Interleukin-13 signaling", "REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING": "Interleukin-3, Interleukin-5 and GM-CSF signaling", "REACTOME_INTERLEUKIN_6_SIGNALING": "Interleukin-6 signaling", "REACTOME_INTERLEUKIN_6_FAMILY_SIGNALING": "Interleukin-6 family signaling", "REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING": "Interleukin receptor SHC signaling", "REACTOME_INTERLEUKIN_9_SIGNALING": "Interleukin-9 signaling", "REACTOME_INTESTINAL_ABSORPTION": "Intestinal absorption", "REACTOME_INTERLEUKIN_7_SIGNALING": "Interleukin-7 signaling", "REACTOME_INTRAFLAGELLAR_TRANSPORT": "Intraflagellar transport", "REACTOME_INTRA_GOLGI_TRAFFIC": "Intra-Golgi traffic", "REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION": "Intrinsic Pathway of Fibrin Clot Formation", "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS": "Intrinsic Pathway for Apoptosis", "REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS": "Ionotropic activity of kainate receptors", "REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS": "Intracellular signaling by second messengers", "REACTOME_INTRA_GOLGI_AND_RETROGRADE_GOLGI_TO_ER_TRAFFIC": "Intra-Golgi and retrograde Golgi-to-ER traffic", "REACTOME_INWARDLY_RECTIFYING_K_CHANNELS": "Inwardly rectifying K+ channels", "REACTOME_ION_HOMEOSTASIS": "Ion homeostasis", "REACTOME_ION_CHANNEL_TRANSPORT": "Ion channel transport", "REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES": "Ion transport by P-type ATPases", "REACTOME_IRAK1_RECRUITS_IKK_COMPLEX": "IRAK1 recruits IKK complex", "REACTOME_IRAK4_DEFICIENCY_TLR2_4": "IRAK4 deficiency (TLR2/4)", "REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX": "IRAK2 mediated activation of TAK1 complex", "REACTOME_IRF3_MEDIATED_ACTIVATION_OF_TYPE_1_IFN": "IRF3 mediated activation of type 1 IFN", "REACTOME_IRE1ALPHA_ACTIVATES_CHAPERONES": "IRE1alpha activates chaperones", "REACTOME_IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN": "IRF3-mediated induction of type I IFN", "REACTOME_IRON_UPTAKE_AND_TRANSPORT": "Iron uptake and transport", "REACTOME_IRS_ACTIVATION": "IRS activation", "REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1", "REACTOME_IRS_MEDIATED_SIGNALLING": "IRS-mediated signalling", "REACTOME_ISG15_ANTIVIRAL_MECHANISM": "ISG15 antiviral mechanism", "REACTOME_JOSEPHIN_DOMAIN_DUBS": "Josephin domain DUBs", "REACTOME_KEAP1_NFE2L2_PATHWAY": "KEAP1-NFE2L2 pathway", "REACTOME_KERATAN_SULFATE_DEGRADATION": "Keratan sulfate degradation", "REACTOME_KERATAN_SULFATE_BIOSYNTHESIS": "Keratan sulfate biosynthesis", "REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM": "Keratan sulfate/keratin metabolism", "REACTOME_KETONE_BODY_METABOLISM": "Ketone body metabolism", "REACTOME_KILLING_MECHANISMS": "Killing mechanisms", "REACTOME_KIDNEY_DEVELOPMENT": "Kidney development", "REACTOME_KSRP_KHSRP_BINDS_AND_DESTABILIZES_MRNA": "KSRP (KHSRP) binds and destabilizes mRNA", "REACTOME_KERATINIZATION": "Keratinization", "REACTOME_KINESINS": "Kinesins", "REACTOME_LAMININ_INTERACTIONS": "Laminin interactions", "REACTOME_L1CAM_INTERACTIONS": "L1CAM interactions", "REACTOME_LAGGING_STRAND_SYNTHESIS": "Lagging Strand Synthesis", "REACTOME_LATE_ENDOSOMAL_MICROAUTOPHAGY": "Late endosomal microautophagy", "REACTOME_LATE_SARS_COV_2_INFECTION_EVENTS": "Late SARS-CoV-2 Infection Events", "REACTOME_LDL_CLEARANCE": "LDL clearance", "REACTOME_LDL_REMODELING": "LDL remodeling", "REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION": "Lectin pathway of complement activation", "REACTOME_LGI_ADAM_INTERACTIONS": "LGI-ADAM interactions", "REACTOME_LEUKOTRIENE_RECEPTORS": "Leukotriene receptors", "REACTOME_LIGAND_RECEPTOR_INTERACTIONS": "Ligand-receptor interactions", "REACTOME_LEISHMANIA_INFECTION": "Leishmania infection", "REACTOME_LINOLEIC_ACID_LA_METABOLISM": "Linoleic acid (LA) metabolism", "REACTOME_LIPID_PARTICLE_ORGANIZATION": "Lipid particle organization", "REACTOME_LONG_TERM_POTENTIATION": "Long-term potentiation", "REACTOME_LIPOPHAGY": "Lipophagy", "REACTOME_LISTERIA_MONOCYTOGENES_ENTRY_INTO_HOST_CELLS": "Listeria monocytogenes entry into host cells", "REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER": "Loss of Function of SMAD2/3 in Cancer", "REACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME": "Loss of function of MECP2 in Rett syndrome", "REACTOME_LOSS_OF_MECP2_BINDING_ABILITY_TO_THE_NCOR_SMRT_COMPLEX": "Loss of MECP2 binding ability to the NCoR/SMRT complex", "REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION": "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "REACTOME_LTC4_CYSLTR_MEDIATED_IL4_PRODUCTION": "LTC4-CYSLTR mediated IL4 production", "REACTOME_LYSINE_CATABOLISM": "Lysine catabolism", "REACTOME_LYSOSPHINGOLIPID_AND_LPA_RECEPTORS": "Lysosphingolipid and LPA receptors", "REACTOME_MALATE_ASPARTATE_SHUTTLE": "Malate-aspartate shuttle", "REACTOME_LYSOSOME_VESICLE_BIOGENESIS": "Lysosome Vesicle Biogenesis", "REACTOME_MAPK1_ERK2_ACTIVATION": "MAPK1 (ERK2) activation", "REACTOME_MAP2K_AND_MAPK_ACTIVATION": "MAP2K and MAPK activation", "REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION": "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "REACTOME_MAPK3_ERK1_ACTIVATION": "MAPK3 (ERK1) activation", "REACTOME_MAPK6_MAPK4_SIGNALING": "MAPK6/MAPK4 signaling", "REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES": "MAPK targets/ Nuclear events mediated by MAP kinases", "REACTOME_MASTL_FACILITATES_MITOTIC_PROGRESSION": "MASTL Facilitates Mitotic Progression", "REACTOME_MAPK_FAMILY_SIGNALING_CASCADES": "MAPK family signaling cascades", "REACTOME_MATERNAL_TO_ZYGOTIC_TRANSITION_MZT": "Maternal to zygotic transition (MZT)", "REACTOME_MATURATION_OF_SARS_COV_1_NUCLEOPROTEIN": "Maturation of nucleoprotein", "REACTOME_MATURATION_OF_PROTEIN_3A": "Maturation of protein 3a", "REACTOME_MATURATION_OF_SARS_COV_2_NUCLEOPROTEIN": "Maturation of nucleoprotein", "REACTOME_MATURATION_OF_TCA_ENZYMES_AND_REGULATION_OF_TCA_CYCLE": "Maturation of TCA enzymes and regulation of TCA cycle", "REACTOME_MATURATION_OF_SARS_COV_2_SPIKE_PROTEIN": "Maturation of spike protein", "REACTOME_MATURATION_OF_SPIKE_PROTEIN": "", "REACTOME_MECP2_REGULATES_NEURONAL_RECEPTORS_AND_CHANNELS": "MECP2 regulates neuronal receptors and channels", "REACTOME_MECP2_REGULATES_TRANSCRIPTION_FACTORS": "MECP2 regulates transcription factors", "REACTOME_MECP2_REGULATES_TRANSCRIPTION_OF_NEURONAL_LIGANDS": "MECP2 regulates transcription of neuronal ligands", "REACTOME_MELANIN_BIOSYNTHESIS": "Melanin biosynthesis", "REACTOME_MEIOSIS": "Meiosis", "REACTOME_MEIOTIC_SYNAPSIS": "Meiotic synapsis", "REACTOME_MEIOTIC_RECOMBINATION": "Meiotic recombination", "REACTOME_METABOLISM_OF_AMINE_DERIVED_HORMONES": "Metabolism of amine-derived hormones", "REACTOME_METABOLIC_DISORDERS_OF_BIOLOGICAL_OXIDATION_ENZYMES": "Metabolic disorders of biological oxidation enzymes", "REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS": "Metabolism of Angiotensinogen to Angiotensins", "REACTOME_METABOLISM_OF_CARBOHYDRATES": "", "REACTOME_METABOLISM_OF_COFACTORS": "Metabolism of cofactors", "REACTOME_MEMBRANE_TRAFFICKING": "Membrane Trafficking", "REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES": "Metabolism of amino acids and derivatives", "REACTOME_METABOLISM_OF_FOLATE_AND_PTERINES": "Metabolism of folate and pterines", "REACTOME_METABOLISM_OF_INGESTED_SEMET_SEC_MESEC_INTO_H2SE": "Metabolism of ingested SeMet, Sec, MeSec into H2Se", "REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS": "Metabolism of fat-soluble vitamins", "REACTOME_METABOLISM_OF_NITRIC_OXIDE_NOS3_ACTIVATION_AND_REGULATION": "Metabolism of nitric oxide: NOS3 activation and regulation", "REACTOME_METABOLISM_OF_NUCLEOTIDES": "Metabolism of nucleotides", "REACTOME_METABOLISM_OF_PORPHYRINS": "Metabolism of porphyrins", "REACTOME_METABOLISM_OF_POLYAMINES": "Metabolism of polyamines", "REACTOME_METABOLISM_OF_LIPIDS": "Metabolism of lipids", "REACTOME_METABOLISM_OF_STEROIDS": "Metabolism of steroids", "REACTOME_METABOLISM_OF_STEROID_HORMONES": "Metabolism of steroid hormones", "REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS": "Metabolism of vitamins and cofactors", "REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS": "Metabolism of water-soluble vitamins and cofactors", "REACTOME_METALLOTHIONEINS_BIND_METALS": "Metallothioneins bind metals", "REACTOME_METALLOPROTEASE_DUBS": "Metalloprotease DUBs", "REACTOME_METABOLISM_OF_RNA": "Metabolism of RNA", "REACTOME_METAL_SEQUESTRATION_BY_ANTIMICROBIAL_PROTEINS": "Metal sequestration by antimicrobial proteins", "REACTOME_METAL_ION_SLC_TRANSPORTERS": "Metal ion SLC transporters", "REACTOME_METHIONINE_SALVAGE_PATHWAY": "Methionine salvage pathway", "REACTOME_MET_ACTIVATES_PI3K_AKT_SIGNALING": "MET activates PI3K/AKT signaling", "REACTOME_METHYLATION": "Methylation", "REACTOME_MET_ACTIVATES_RAP1_AND_RAC1": "MET activates RAP1 and RAC1", "REACTOME_MET_ACTIVATES_PTPN11": "MET activates PTPN11", "REACTOME_MET_ACTIVATES_PTK2_SIGNALING": "MET activates PTK2 signaling", "REACTOME_MET_ACTIVATES_RAS_SIGNALING": "MET activates RAS signaling", "REACTOME_MET_RECEPTOR_RECYCLING": "MET receptor recycling", "REACTOME_MET_INTERACTS_WITH_TNS_PROTEINS": "MET interacts with TNS proteins", "REACTOME_MET_RECEPTOR_ACTIVATION": "MET Receptor Activation", "REACTOME_MET_PROMOTES_CELL_MOTILITY": "MET promotes cell motility", "REACTOME_MICRORNA_MIRNA_BIOGENESIS": "MicroRNA (miRNA) biogenesis", "REACTOME_MINERALOCORTICOID_BIOSYNTHESIS": "Mineralocorticoid biosynthesis", "REACTOME_MIRO_GTPASE_CYCLE": "Miro GTPase Cycle", "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION": "MHC class II antigen presentation", "REACTOME_MISCELLANEOUS_SUBSTRATES": "Miscellaneous substrates", "REACTOME_MISMATCH_REPAIR": "Mismatch Repair", "REACTOME_MISCELLANEOUS_TRANSPORT_AND_BINDING_EVENTS": "Miscellaneous transport and binding events", "REACTOME_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT": "Mitochondrial calcium ion transport", "REACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION": "MITF-M-dependent gene expression", "REACTOME_MITOCHONDRIAL_BIOGENESIS": "Mitochondrial biogenesis", "REACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT": "MITF-M-regulated melanocyte development", "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION_OF_SATURATED_FATTY_ACIDS": "mitochondrial fatty acid beta-oxidation of saturated fatty acids", "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION_OF_UNSATURATED_FATTY_ACIDS": "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION": "Mitochondrial Fatty Acid Beta-Oxidation", "REACTOME_MITOCHONDRIAL_IRON_SULFUR_CLUSTER_BIOGENESIS": "Mitochondrial iron-sulfur cluster biogenesis", "REACTOME_MITOCHONDRIAL_RNA_DEGRADATION": "Mitochondrial RNA degradation", "REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION": "Mitochondrial protein degradation", "REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT": "Mitochondrial protein import", "REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION": "Mitochondrial tRNA aminoacylation", "REACTOME_MITOCHONDRIAL_UNCOUPLING": "Mitochondrial Uncoupling", "REACTOME_MITOCHONDRIAL_TRANSLATION": "Mitochondrial translation", "REACTOME_MITOPHAGY": "Mitophagy", "REACTOME_MITOTIC_G2_G2_M_PHASES": "Mitotic G2-G2/M phases", "REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION": "Mitotic G1 phase and G1/S transition", "REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS": "Mitotic Telophase/Cytokinesis", "REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE": "Mitotic Metaphase and Anaphase", "REACTOME_MITOTIC_PROPHASE": "Mitotic Prophase", "REACTOME_MITOTIC_PROMETAPHASE": "Mitotic Prometaphase", "REACTOME_MITOTIC_SPINDLE_CHECKPOINT": "Mitotic Spindle Checkpoint", "REACTOME_MODULATION_BY_MTB_OF_HOST_IMMUNE_SYSTEM": "Modulation by Mtb of host immune system", "REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES": "Molecules associated with elastic fibres", "REACTOME_MOLYBDENUM_COFACTOR_BIOSYNTHESIS": "Molybdenum cofactor biosynthesis", "REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE": "mRNA decay by 3' to 5' exoribonuclease", "REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE": "mRNA decay by 5' to 3' exoribonuclease", "REACTOME_MRNA_CAPPING": "mRNA Capping", "REACTOME_MRNA_EDITING": "mRNA Editing", "REACTOME_MTORC1_MEDIATED_SIGNALLING": "mTORC1-mediated signalling", "REACTOME_MRNA_EDITING_C_TO_U_CONVERSION": "mRNA Editing: C to U Conversion", "REACTOME_MUCOPOLYSACCHARIDOSES": "Mucopolysaccharidoses", "REACTOME_MRNA_SPLICING_MINOR_PATHWAY": "mRNA Splicing - Minor Pathway", "REACTOME_MTOR_SIGNALLING": "MTOR signalling", "REACTOME_MRNA_SPLICING": "mRNA Splicing", "REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS": "Muscarinic acetylcholine receptors", "REACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS": "", "REACTOME_MYOGENESIS": "Myogenesis", "REACTOME_MYOCLONIC_EPILEPSY_OF_LAFORA": "Myoclonic epilepsy of Lafora", "REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE": "MyD88-independent TLR4 cascade", "REACTOME_MUSCLE_CONTRACTION": "Muscle contraction", "REACTOME_M_DECAY_DEGRADATION_OF_MATERNAL_MRNAS_BY_MATERNALLY_STORED_FACTORS": "M-decay: degradation of maternal mRNAs by maternally stored factors", "REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS": "", "REACTOME_NADE_MODULATES_DEATH_SIGNALLING": "NADE modulates death signalling", "REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH": "NCAM signaling for neurite out-growth", "REACTOME_NCAM1_INTERACTIONS": "NCAM1 interactions", "REACTOME_M_PHASE": "M Phase", "REACTOME_NECTIN_NECL_TRANS_HETERODIMERIZATION": "Nectin/Necl  trans heterodimerization", "REACTOME_NEF_MEDIATED_CD4_DOWN_REGULATION": "Nef Mediated CD4 Down-regulation", "REACTOME_NEF_AND_SIGNAL_TRANSDUCTION": "Nef and signal transduction", "REACTOME_NEDDYLATION": "Neddylation", "REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS": "Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "REACTOME_NEF_MEDIATED_CD8_DOWN_REGULATION": "Nef Mediated CD8 Down-regulation", "REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION": "Nef mediated downregulation of MHC class I complex cell surface expression", "REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS": "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY": "Negative feedback regulation of MAPK pathway", "REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION": "Negative epigenetic regulation of rRNA expression", "REACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING": "Negative regulation of FGFR1 signaling", "REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING": "Negative regulation of FGFR3 signaling", "REACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING": "Negative regulation of FGFR2 signaling", "REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING": "Negative regulation of FGFR4 signaling", "REACTOME_NEGATIVE_REGULATION_OF_MET_ACTIVITY": "Negative regulation of MET activity", "REACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION": "Negative regulation of NMDA receptor-mediated neuronal transmission", "REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY": "Negative regulation of MAPK pathway", "REACTOME_NEGATIVE_REGULATION_OF_FLT3": "Negative regulation of FLT3", "REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_DVL_INTERACTING_PROTEINS": "Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "REACTOME_NEGATIVE_REGULATION_OF_NOTCH4_SIGNALING": "Negative regulation of NOTCH4 signaling", "REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS": "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "REACTOME_NEPHRIN_FAMILY_INTERACTIONS": "Nephrin family interactions", "REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK": "Negative regulation of the PI3K/AKT network", "REACTOME_NEPHRON_DEVELOPMENT": "Nephron development", "REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING": "Negative regulators of DDX58/IFIH1 signaling", "REACTOME_NETRIN_MEDIATED_REPULSION_SIGNALS": "Netrin mediated repulsion signals", "REACTOME_NEUROFASCIN_INTERACTIONS": "Neurofascin interactions", "REACTOME_NETRIN_1_SIGNALING": "Netrin-1 signaling", "REACTOME_NEUREXINS_AND_NEUROLIGINS": "Neurexins and neuroligins", "REACTOME_NERVOUS_SYSTEM_DEVELOPMENT": "Nervous system development", "REACTOME_NEUROTRANSMITTER_CLEARANCE": "Neurotransmitter clearance", "REACTOME_NEUROTOXICITY_OF_CLOSTRIDIUM_TOXINS": "Neurotoxicity of clostridium toxins", "REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE": "Neurotransmitter release cycle", "REACTOME_NEURONAL_SYSTEM": "Neuronal System", "REACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES": "NFE2L2 regulating anti-oxidant/detoxification enzymes", "REACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES": "NFE2L2 regulates pentose phosphate pathway genes", "REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION": "Neurotransmitter receptors and postsynaptic signal transmission", "REACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES": "NFE2L2 regulating ER-stress associated genes", "REACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES": "NFE2L2 regulating tumorigenic genes", "REACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES": "NFE2L2 regulating inflammation associated genes", "REACTOME_NEUTROPHIL_DEGRANULATION": "Neutrophil degranulation", "REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES": "NFE2L2 regulating MDR associated enzymes", "REACTOME_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL": "NF-kB is activated and signals survival", "REACTOME_NF_KB_ACTIVATION_THROUGH_FADD_RIP_1_PATHWAY_MEDIATED_BY_CASPASE_8_AND_10": "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "REACTOME_NGF_INDEPENDANT_TRKA_ACTIVATION": "NGF-independant TRKA activation", "REACTOME_NICOTINAMIDE_SALVAGING": "", "REACTOME_NICOTINATE_METABOLISM": "Nicotinate metabolism", "REACTOME_NGF_STIMULATED_TRANSCRIPTION": "NGF-stimulated transcription", "REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE": "Nitric oxide stimulates guanylate cyclase", "REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3": "Noncanonical activation of NOTCH3", "REACTOME_NOD1_2_SIGNALING_PATHWAY": "NOD1/2 Signaling Pathway", "REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ": "Nonhomologous End-Joining (NHEJ)", "REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE": "Norepinephrine Neurotransmitter Release Cycle", "REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS": "Non-integrin membrane-ECM interactions", "REACTOME_NOSTRIN_MEDIATED_ENOS_TRAFFICKING": "NOSTRIN mediated eNOS trafficking", "REACTOME_NONSENSE_MEDIATED_DECAY_NMD": "Nonsense-Mediated Decay (NMD)", "REACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS": "NOTCH2 Activation and Transmission of Signal to the Nucleus", "REACTOME_NOTCH2_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION": "NOTCH2 intracellular domain regulates transcription", "REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION": "NOTCH1 Intracellular Domain Regulates Transcription", "REACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS": "NOTCH3 Activation and Transmission of Signal to the Nucleus", "REACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS": "NOTCH4 Activation and Transmission of Signal to the Nucleus", "REACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION": "NOTCH3 Intracellular Domain Regulates Transcription", "REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION": "NOTCH4 Intracellular Domain Regulates Transcription", "REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY": "Notch-HLH transcription pathway", "REACTOME_NPAS4_REGULATES_EXPRESSION_OF_TARGET_GENES": "NPAS4 regulates expression of target genes", "REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_GLUCONEOGENESIS": "NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis", "REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING": "NR1H2 and NR1H3-mediated signaling", "REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_LIMIT_CHOLESTEROL_UPTAKE": "NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake", "REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS": "NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis", "REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_LIPOGENESIS": "NR1H2 & NR1H3 regulate gene expression linked to lipogenesis", "REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX": "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_TRIGLYCERIDE_LIPOLYSIS_IN_ADIPOSE": "NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose", "REACTOME_NRCAM_INTERACTIONS": "NrCAM interactions", "REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK": "NRAGE signals death through JNK", "REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS": "NRIF signals cell death from the nucleus", "REACTOME_NTRK2_ACTIVATES_RAC1": "NTRK2 activates RAC1", "REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS": "NS1 Mediated Effects on Host Pathways", "REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN": "Nuclear Envelope Breakdown", "REACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY": "Nuclear Envelope (NE) Reassembly", "REACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER": "Nuclear events stimulated by ALK signaling in cancer", "REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION": "Nuclear Events (kinase and transcription factor activation)", "REACTOME_NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2": "Nuclear events mediated by NFE2L2", "REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN": "Nuclear import of Rev protein", "REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY": "Nuclear Pore Complex (NPC) Disassembly", "REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY": "Nuclear Receptor transcription pathway", "REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS": "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways", "REACTOME_NUCLEOTIDE_BIOSYNTHESIS": "Nucleotide biosynthesis", "REACTOME_NUCLEAR_SIGNALING_BY_ERBB4": "Nuclear signaling by ERBB4", "REACTOME_NUCLEOTIDE_CATABOLISM": "Nucleotide catabolism", "REACTOME_NUCLEOTIDE_SALVAGE": "Nucleotide salvage", "REACTOME_NUCLEOTIDE_EXCISION_REPAIR": "Nucleotide Excision Repair", "REACTOME_N_GLYCAN_ANTENNAE_ELONGATION": "N-Glycan antennae elongation", "REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS": "Nucleotide-like (purinergic) receptors", "REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI": "N-glycan antennae elongation in the medial/trans-Golgi", "REACTOME_N_GLYCAN_TRIMMING_AND_ELONGATION_IN_THE_CIS_GOLGI": "N-glycan trimming and elongation in the cis-Golgi", "REACTOME_OAS_ANTIVIRAL_RESPONSE": "OAS antiviral response", "REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE": "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "REACTOME_ONCOGENE_INDUCED_SENESCENCE": "Oncogene Induced Senescence", "REACTOME_OPSINS": "Opsins", "REACTOME_OLFACTORY_SIGNALING_PATHWAY": "Olfactory Signaling Pathway", "REACTOME_ONCOGENIC_MAPK_SIGNALING": "Oncogenic MAPK signaling", "REACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS": "Orexin and neuropeptides FF and QRFP bind to their respective receptors", "REACTOME_OPIOID_SIGNALLING": "Opioid Signalling", "REACTOME_ORC1_REMOVAL_FROM_CHROMATIN": "Orc1 removal from chromatin", "REACTOME_ORGANIC_ANION_TRANSPORTERS": "", "REACTOME_ORGANIC_ANION_TRANSPORT": "", "REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT": "", "REACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE": "Organelle biogenesis and maintenance", "REACTOME_ORGANIC_CATION_TRANSPORT": "", "REACTOME_OTHER_SEMAPHORIN_INTERACTIONS": "Other semaphorin interactions", "REACTOME_OTHER_INTERLEUKIN_SIGNALING": "Other interleukin signaling", "REACTOME_OVARIAN_TUMOR_DOMAIN_PROTEASES": "Ovarian tumor domain proteases", "REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS": "O-glycosylation of TSR domain-containing proteins", "REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS": "O-linked glycosylation of mucins", "REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE": "Oxidative Stress Induced Senescence", "REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS": "p130Cas linkage to MAPK signaling for integrins", "REACTOME_P2Y_RECEPTORS": "P2Y receptors", "REACTOME_P38MAPK_EVENTS": "p38MAPK events", "REACTOME_O_LINKED_GLYCOSYLATION": "O-linked glycosylation", "REACTOME_P75NTR_NEGATIVELY_REGULATES_CELL_CYCLE_VIA_SC1": "p75NTR negatively regulates cell cycle via SC1", "REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES": "p75NTR recruits signalling complexes", "REACTOME_P75NTR_REGULATES_AXONOGENESIS": "p75NTR regulates axonogenesis", "REACTOME_P75NTR_SIGNALS_VIA_NF_KB": "p75NTR signals via NF-kB", "REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING": "p75 NTR receptor-mediated signalling", "REACTOME_PARACETAMOL_ADME": "Paracetamol ADME", "REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS": "Passive transport by Aquaporins", "REACTOME_PCNA_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR": "PCNA-Dependent Long Patch Base Excision Repair", "REACTOME_PDH_COMPLEX_SYNTHESIZES_ACETYL_COA_FROM_PYR": "PDH complex synthesizes acetyl-CoA from PYR", "REACTOME_PD_1_SIGNALING": "", "REACTOME_PARASITE_INFECTION": "Parasite infection", "REACTOME_PCP_CE_PATHWAY": "PCP/CE pathway", "REACTOME_PECAM1_INTERACTIONS": "PECAM1 interactions", "REACTOME_PENTOSE_PHOSPHATE_PATHWAY": "Pentose phosphate pathway", "REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS": "Peptide hormone biosynthesis", "REACTOME_PEPTIDE_HORMONE_METABOLISM": "Peptide hormone metabolism", "REACTOME_PEROXISOMAL_LIPID_METABOLISM": "Peroxisomal lipid metabolism", "REACTOME_PERK_REGULATES_GENE_EXPRESSION": "PERK regulates gene expression", "REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS": "Peptide ligand-binding receptors", "REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS": "Phase 1 - inactivation of fast Na+ channels", "REACTOME_PEXOPHAGY": "Pexophagy", "REACTOME_PEROXISOMAL_PROTEIN_IMPORT": "Peroxisomal protein import", "REACTOME_PHASE_0_RAPID_DEPOLARISATION": "Phase 0 - rapid depolarisation", "REACTOME_PHASE_2_PLATEAU_PHASE": "Phase 2 - plateau phase", "REACTOME_PHASE_3_RAPID_REPOLARISATION": "Phase 3 - rapid repolarisation", "REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL": "Phase 4 - resting membrane potential", "REACTOME_PHENYLALANINE_AND_TYROSINE_METABOLISM": "Phenylalanine and tyrosine metabolism", "REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS": "Phase II - Conjugation of compounds", "REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS": "Phase I - Functionalization of compounds", "REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS": "Phosphate bond hydrolysis by NTPDase proteins", "REACTOME_PHENYLALANINE_METABOLISM": "Phenylalanine metabolism", "REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR1": "Phospholipase C-mediated cascade: FGFR1", "REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NUDT_PROTEINS": "Phosphate bond hydrolysis by NUDT proteins", "REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR4": "Phospholipase C-mediated cascade; FGFR4", "REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR2": "Phospholipase C-mediated cascade; FGFR2", "REACTOME_PHOSPHORYLATION_OF_EMI1": "Phosphorylation of Emi1", "REACTOME_PHOSPHORYLATION_OF_THE_APC_C": "Phosphorylation of the APC/C", "REACTOME_PHYSIOLOGICAL_FACTORS": "Physiological factors", "REACTOME_PHOSPHOLIPID_METABOLISM": "Phospholipid metabolism", "REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING": "PI3K events in ERBB4 signaling", "REACTOME_PI3K_AKT_ACTIVATION": "PI3K/AKT activation", "REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING": "PI3K events in ERBB2 signaling", "REACTOME_PI3K_AKT_SIGNALING_IN_CANCER": "PI3K/AKT Signaling in Cancer", "REACTOME_PI5P_REGULATES_TP53_ACETYLATION": "PI5P Regulates TP53 Acetylation", "REACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY": "PINK1-PRKN Mediated Mitophagy", "REACTOME_PI_3K_CASCADE_FGFR1": "PI-3K cascade:FGFR1", "REACTOME_PIWI_INTERACTING_RNA_PIRNA_BIOGENESIS": "PIWI-interacting RNA (piRNA) biogenesis", "REACTOME_PI_3K_CASCADE_FGFR2": "PI-3K cascade:FGFR2", "REACTOME_PI_3K_CASCADE_FGFR3": "PI-3K cascade:FGFR3", "REACTOME_PI_3K_CASCADE_FGFR4": "PI-3K cascade:FGFR4", "REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB": "PKA-mediated phosphorylation of CREB", "REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING": "PKA activation in glucagon signalling", "REACTOME_PI_METABOLISM": "PI Metabolism", "REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS": "PKA-mediated phosphorylation of key metabolic factors", "REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY": "Plasma lipoprotein assembly", "REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES": "PKMTs methylate histone lysines", "REACTOME_PKR_MEDIATED_SIGNALING": "PKR-mediated signaling", "REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE": "Plasma lipoprotein assembly, remodeling, and clearance", "REACTOME_PLASMA_LIPOPROTEIN_REMODELING": "Plasma lipoprotein remodeling", "REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE": "Plasma lipoprotein clearance", "REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION": "Platelet Aggregation (Plug Formation)", "REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION": "Platelet activation, signaling and aggregation", "REACTOME_PLATELET_SENSITIZATION_BY_LDL": "Platelet sensitization by LDL", "REACTOME_PLATELET_CALCIUM_HOMEOSTASIS": "Platelet calcium homeostasis", "REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN": "Platelet Adhesion to exposed collagen", "REACTOME_POLB_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR": "POLB-Dependent Long Patch Base Excision Repair", "REACTOME_POLO_LIKE_KINASE_MEDIATED_EVENTS": "Polo-like kinase mediated events", "REACTOME_PLATELET_HOMEOSTASIS": "Platelet homeostasis", "REACTOME_POLYMERASE_SWITCHING": "Polymerase switching", "REACTOME_POLYMERASE_SWITCHING_ON_THE_C_STRAND_OF_THE_TELOMERE": "Polymerase switching on the C-strand of the telomere", "REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION": "Positive epigenetic regulation of rRNA expression", "REACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION": "Postmitotic nuclear pore complex (NPC) reformation", "REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS": "Post-transcriptional silencing by small RNAs", "REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS": "Post-translational modification: synthesis of GPI-anchored proteins", "REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY": "Post-chaperonin tubulin folding pathway", "REACTOME_POTASSIUM_CHANNELS": "Potassium Channels", "REACTOME_POU5F1_OCT4_SOX2_NANOG_ACTIVATE_GENES_RELATED_TO_PROLIFERATION": "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION": "POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "REACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS": "PP2A-mediated dephosphorylation of key metabolic factors", "REACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS": "Potential therapeutics for SARS", "REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA": "PRC2 methylates histones and DNA", "REACTOME_PREDNISONE_ADME": "Prednisone ADME", "REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION": "Post-translational protein modification", "REACTOME_PREGNENOLONE_BIOSYNTHESIS": "Pregnenolone biosynthesis", "REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING": "Presynaptic depolarization and calcium channel opening", "REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS": "Presynaptic nicotinic acetylcholine receptors", "REACTOME_PREVENTION_OF_PHAGOSOMAL_LYSOSOMAL_FUSION": "Prevention of phagosomal-lysosomal fusion", "REACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS": "Presynaptic function of Kainate receptors", "REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI": "Pre-NOTCH Processing in Golgi", "REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING": "Pre-NOTCH Expression and Processing", "REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM": "Pre-NOTCH Processing in the Endoplasmic Reticulum", "REACTOME_PROCESSING_AND_ACTIVATION_OF_SUMO": "Processing and activation of SUMO", "REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA": "Processing of Capped Intronless Pre-mRNA", "REACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS": "Processing of DNA double-strand break ends", "REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS": "Processing of Intronless Pre-mRNAs", "REACTOME_PROCESSING_OF_SMDT1": "Processing of SMDT1", "REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_C_STRAND_OF_THE_TELOMERE": "Processive synthesis on the C-strand of the telomere", "REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND": "Processive synthesis on the lagging strand", "REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA": "Processing of Capped Intron-Containing Pre-mRNA", "REACTOME_PROLACTIN_RECEPTOR_SIGNALING": "Prolactin receptor signaling", "REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS": "Prolonged ERK activation events", "REACTOME_PROGRAMMED_CELL_DEATH": "Programmed Cell Death", "REACTOME_PROPIONYL_COA_CATABOLISM": "Propionyl-CoA catabolism", "REACTOME_PROSTANOID_LIGAND_RECEPTORS": "Prostanoid ligand receptors", "REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR": "Prostacyclin signalling through prostacyclin receptor", "REACTOME_PROTEIN_HYDROXYLATION": "Protein hydroxylation", "REACTOME_PROTEIN_LIPOYLATION": "Protein lipoylation", "REACTOME_PROTEIN_FOLDING": "Protein folding", "REACTOME_PROTEIN_METHYLATION": "Protein methylation", "REACTOME_PROTEIN_REPAIR": "Protein repair", "REACTOME_PROTEIN_LOCALIZATION": "Protein localization", "REACTOME_PROTEIN_UBIQUITINATION": "Protein ubiquitination", "REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES": "Protein-protein interactions at synapses", "REACTOME_PTK6_EXPRESSION": "PTK6 Expression", "REACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT": "Proton-coupled monocarboxylate transport", "REACTOME_PTK6_PROMOTES_HIF1A_STABILIZATION": "PTK6 promotes HIF1A stabilization", "REACTOME_PTEN_REGULATION": "PTEN Regulation", "REACTOME_PTK6_REGULATES_CELL_CYCLE": "PTK6 Regulates Cell Cycle", "REACTOME_PTK6_REGULATES_PROTEINS_INVOLVED_IN_RNA_PROCESSING": "PTK6 Regulates Proteins Involved in RNA Processing", "REACTOME_PTK6_REGULATES_RTKS_AND_THEIR_EFFECTORS_AKT1_AND_DOK1": "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "REACTOME_PURINE_CATABOLISM": "Purine catabolism", "REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES": "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "REACTOME_PURINERGIC_SIGNALING_IN_LEISHMANIASIS_INFECTION": "Purinergic signaling in leishmaniasis infection", "REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS": "Purine ribonucleoside monophosphate biosynthesis", "REACTOME_PURINE_SALVAGE": "Purine salvage", "REACTOME_PYRIMIDINE_CATABOLISM": "Pyrimidine catabolism", "REACTOME_PYRIMIDINE_SALVAGE": "Pyrimidine salvage", "REACTOME_PYROPTOSIS": "Pyroptosis", "REACTOME_PYRUVATE_METABOLISM": "Pyruvate metabolism", "REACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS": "RAB GEFs exchange GTP for GDP on RABs", "REACTOME_RAB_GERANYLGERANYLATION": "RAB geranylgeranylation", "REACTOME_RAB_REGULATION_OF_TRAFFICKING": "Rab regulation of trafficking", "REACTOME_RAC2_GTPASE_CYCLE": "RAC2 GTPase cycle", "REACTOME_RAC3_GTPASE_CYCLE": "RAC3 GTPase cycle", "REACTOME_RAC1_GTPASE_CYCLE": "RAC1 GTPase cycle", "REACTOME_RAF_ACTIVATION": "RAF activation", "REACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION": "RAF-independent MAPK1/3 activation", "REACTOME_RAP1_SIGNALLING": "Rap1 signalling", "REACTOME_RAS_ACTIVATION_UPON_CA2_INFLUX_THROUGH_NMDA_RECEPTOR": "Ras activation upon Ca2+ influx through NMDA receptor", "REACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS": "RAS signaling downstream of NF1 loss-of-function variants", "REACTOME_RAS_PROCESSING": "RAS processing", "REACTOME_RA_BIOSYNTHESIS_PATHWAY": "RA biosynthesis pathway", "REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY": "Reactions specific to the complex N-glycan synthesis pathway", "REACTOME_RECOGNITION_OF_DNA_DAMAGE_BY_PCNA_CONTAINING_REPLICATION_COMPLEX": "Recognition of DNA damage by PCNA-containing replication complex", "REACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES": "Receptor-type tyrosine-protein phosphatases", "REACTOME_RECEPTOR_MEDIATED_MITOPHAGY": "Receptor Mediated Mitophagy", "REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES": "Recruitment of mitotic centrosome proteins and complexes", "REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES": "Recruitment of NuMA to mitotic centrosomes", "REACTOME_RECOGNITION_AND_ASSOCIATION_OF_DNA_GLYCOSYLASE_WITH_SITE_CONTAINING_AN_AFFECTED_PURINE": "Recognition and association of DNA glycosylase with site containing an affected purine", "REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS": "Recycling of bile acids and salts", "REACTOME_RECYCLING_OF_EIF2_GDP": "Recycling of eIF2:GDP", "REACTOME_RECYCLING_PATHWAY_OF_L1": "Recycling pathway of L1", "REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS": "Reduction of cytosolic Ca++ levels", "REACTOME_REELIN_SIGNALLING_PATHWAY": "Reelin signalling pathway", "REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR": "Regulated proteolysis of p75NTR", "REACTOME_REGULATED_NECROSIS": "Regulated Necrosis", "REACTOME_REGULATION_BY_C_FLIP": "Regulation by c-FLIP", "REACTOME_REGULATION_OF_CDH11_FUNCTION": "Regulation of CDH11 function", "REACTOME_REGULATION_OF_BACH1_ACTIVITY": "Regulation of BACH1 activity", "REACTOME_REGULATION_OF_CDH11_GENE_TRANSCRIPTION": "Regulation of CDH11 gene transcription", "REACTOME_REGULATION_OF_CDH19_EXPRESSION_AND_FUNCTION": "Regulation of CDH19 Expression and Function", "REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT": "Regulation of beta-cell development", "REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS": "Regulation of CDH11 mRNA translation by microRNAs", "REACTOME_REGULATION_OF_COMMISSURAL_AXON_PATHFINDING_BY_SLIT_AND_ROBO": "Regulation of commissural axon pathfinding by SLIT and ROBO", "REACTOME_REGULATION_OF_CYTOSKELETAL_REMODELING_AND_CELL_SPREADING_BY_IPP_COMPLEX_COMPONENTS": "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF": "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS": "Regulation of endogenous retroelements", "REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION": "Regulation of FZD by ubiquitination", "REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_KRAB_ZFP_PROTEINS": "Regulation of endogenous retroelements by KRAB-ZFP proteins", "REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION": "Regulation of FOXO transcriptional activity by acetylation", "REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR": "Regulation of gene expression by Hypoxia-inducible Factor", "REACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS": "Regulation of expression of SLITs and ROBOs", "REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS": "Regulation of gene expression in beta cells", "REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_EARLY_PANCREATIC_PRECURSOR_CELLS": "Regulation of gene expression in early pancreatic precursor cells", "REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_PIWI_INTERACTING_RNAS_PIRNAS": "Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_THE_HUMAN_SILENCING_HUB_HUSH_COMPLEX": "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS": "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_ENDOCRINE_COMMITTED_NEUROG3_PROGENITOR_CELLS": "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells", "REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM": "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism", "REACTOME_REGULATION_OF_HMOX1_EXPRESSION_AND_ACTIVITY": "Regulation of HMOX1 expression and activity", "REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN": "Regulation of Glucokinase by Glucokinase Regulatory Protein", "REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING": "Regulation of IFNA/IFNB signaling", "REACTOME_REGULATION_OF_IFNG_SIGNALING": "Regulation of IFNG signaling", "REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA": "Regulation of innate immune responses to cytosolic DNA", "REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE": "Regulation of HSF1-mediated heat shock response", "REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION": "Regulation of Homotypic Cell-Cell Adhesion", "REACTOME_REGULATION_OF_INSULIN_SECRETION": "Regulation of insulin secretion", "REACTOME_REGULATION_OF_KIT_SIGNALING": "Regulation of KIT signaling", "REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS": "Regulation of localization of FOXO transcription factors", "REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA": "Regulation of lipid metabolism by PPARalpha", "REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_CELL_CYCLE_AND_PROLIFERATION": "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS": "Regulation of MITF-M-dependent genes involved in apoptosis", "REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_LYSOSOME_BIOGENESIS_AND_AUTOPHAGY": "Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY": "Regulation of MECP2 expression and activity", "REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_PIGMENTATION": "Regulation of MITF-M-dependent genes involved in pigmentation", "REACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION": "Regulation of NFE2L2 gene expression", "REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS": "Regulation of mRNA stability by proteins that bind AU-rich elements", "REACTOME_REGULATION_OF_NF_KAPPA_B_SIGNALING": "Regulation of NF-kappa B signaling", "REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION": "Regulation of NPAS4 gene expression", "REACTOME_REGULATION_OF_NPAS4_GENE_TRANSCRIPTION": "Regulation of NPAS4 gene transcription", "REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION": "Regulation of NPAS4 mRNA translation", "REACTOME_REGULATION_OF_PTEN_LOCALIZATION": "Regulation of PTEN localization", "REACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION": "Regulation of PLK1 Activity at G2/M Transition", "REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION": "Regulation of PTEN gene transcription", "REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION": "Regulation of PTEN mRNA translation", "REACTOME_REGULATION_OF_PYRUVATE_METABOLISM": "Regulation of pyruvate metabolism", "REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX": "Regulation of pyruvate dehydrogenase (PDH) complex", "REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY": "Regulation of RUNX1 Expression and Activity", "REACTOME_REGULATION_OF_PTEN_STABILITY_AND_ACTIVITY": "Regulation of PTEN stability and activity", "REACTOME_REGULATION_OF_RAS_BY_GAPS": "Regulation of RAS by GAPs", "REACTOME_REGULATION_OF_RUNX2_EXPRESSION_AND_ACTIVITY": "Regulation of RUNX2 expression and activity", "REACTOME_REGULATION_OF_SIGNALING_BY_CBL": "Regulation of signaling by CBL", "REACTOME_REGULATION_OF_RUNX3_EXPRESSION_AND_ACTIVITY": "Regulation of RUNX3 expression and activity", "REACTOME_REGULATION_OF_SIGNALING_BY_NODAL": "Regulation of signaling by NODAL", "REACTOME_REGULATION_OF_TBK1_IKK_MEDIATED_ACTIVATION_OF_IRF3_IRF7_UPON_TLR3_LIGATION": "Regulation of TBK1, IKK?-mediated activation of IRF3, IRF7 upon TLR3 ligation", "REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7": "Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7", "REACTOME_REGULATION_OF_TLR_BY_ENDOGENOUS_LIGAND": "Regulation of TLR by endogenous ligand", "REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS": "Regulation of TP53 Activity through Association with Co-factors", "REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION": "Regulation of TP53 Activity through Acetylation", "REACTOME_REGULATION_OF_TP53_ACTIVITY": "Regulation of TP53 Activity", "REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_METHYLATION": "Regulation of TP53 Activity through Methylation", "REACTOME_RELAXIN_RECEPTORS": "Relaxin receptors", "REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION": "Regulation of TP53 Activity through Phosphorylation", "REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL": "Release of Hh-Np from the secreting cell", "REACTOME_RELEASE_OF_APOPTOTIC_FACTORS_FROM_THE_MITOCHONDRIA": "Release of apoptotic factors from the mitochondria", "REACTOME_REMOVAL_OF_AMINOTERMINAL_PROPEPTIDES_FROM_GAMMA_CARBOXYLATED_PROTEINS": "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION": "Regulation of TP53 Expression and Degradation", "REACTOME_REPLACEMENT_OF_PROTAMINES_BY_NUCLEOSOMES_IN_THE_MALE_PRONUCLEUS": "Replacement of protamines by nucleosomes in the male pronucleus", "REACTOME_REPRESSION_OF_WNT_TARGET_GENES": "Repression of WNT target genes", "REACTOME_REPRODUCTION": "Reproduction", "REACTOME_RESOLUTION_OF_ABASIC_SITES_AP_SITES": "Resolution of Abasic Sites (AP sites)", "REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY": "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA": "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES": "Resolution of D-Loop Structures", "REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION": "Resolution of Sister Chromatid Cohesion", "REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_ATTACHMENT_AND_ENTRY": "Respiratory syncytial virus (RSV) attachment and entry", "REACTOME_RESPIRATORY_ELECTRON_TRANSPORT": "Respiratory electron transport", "REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION": "Respiratory syncytial virus (RSV) genome replication, transcription and translation", "REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY": "Respiratory Syncytial Virus Infection Pathway", "REACTOME_RESPONSE_OF_EIF2AK1_HRI_TO_HEME_DEFICIENCY": "Response of EIF2AK1 (HRI) to heme deficiency", "REACTOME_RESPONSE_OF_MTB_TO_PHAGOCYTOSIS": "Response of Mtb to phagocytosis", "REACTOME_RESPONSE_TO_METAL_IONS": "Response to metal ions", "REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY": "Response of EIF2AK4 (GCN2) to amino acid deficiency", "REACTOME_RETINOID_CYCLE_DISEASE_EVENTS": "Retinoid cycle disease events", "REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING": "Retrograde neurotrophin signalling", "REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2": "Response to elevated platelet cytosolic Ca2+", "REACTOME_RETROGRADE_TRANSPORT_AT_THE_TRANS_GOLGI_NETWORK": "Retrograde transport at the Trans-Golgi-Network", "REACTOME_RET_SIGNALING": "RET signaling", "REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE": "Reversible hydration of carbon dioxide", "REACTOME_RHOBTB1_GTPASE_CYCLE": "RHOBTB1 GTPase cycle", "REACTOME_RHOBTB2_GTPASE_CYCLE": "RHOBTB2 GTPase cycle", "REACTOME_RHOA_GTPASE_CYCLE": "RHOA GTPase cycle", "REACTOME_RHOBTB3_ATPASE_CYCLE": "RHOBTB3 ATPase cycle", "REACTOME_RHOBTB_GTPASE_CYCLE": "RHOBTB GTPase Cycle", "REACTOME_RHOB_GTPASE_CYCLE": "RHOB GTPase cycle", "REACTOME_RHOC_GTPASE_CYCLE": "RHOC GTPase cycle", "REACTOME_RHOF_GTPASE_CYCLE": "RHOF GTPase cycle", "REACTOME_RHOD_GTPASE_CYCLE": "RHOD GTPase cycle", "REACTOME_RHOG_GTPASE_CYCLE": "RHOG GTPase cycle", "REACTOME_RHOT1_GTPASE_CYCLE": "RHOT1 GTPase cycle", "REACTOME_RHOH_GTPASE_CYCLE": "RHOH GTPase cycle", "REACTOME_RHOJ_GTPASE_CYCLE": "RHOJ GTPase cycle", "REACTOME_RHOQ_GTPASE_CYCLE": "RHOQ GTPase cycle", "REACTOME_RHOU_GTPASE_CYCLE": "RHOU GTPase cycle", "REACTOME_RHO_GTPASES_ACTIVATE_CIT": "RHO GTPases activate CIT", "REACTOME_RHOV_GTPASE_CYCLE": "RHOV GTPase cycle", "REACTOME_RHO_GTPASES_ACTIVATE_IQGAPS": "RHO GTPases activate IQGAPs", "REACTOME_RHO_GTPASES_ACTIVATE_KTN1": "RHO GTPases activate KTN1", "REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES": "RHO GTPases Activate NADPH Oxidases", "REACTOME_RHO_GTPASES_ACTIVATE_FORMINS": "RHO GTPases Activate Formins", "REACTOME_RHO_GTPASES_ACTIVATE_PAKS": "RHO GTPases activate PAKs", "REACTOME_RHO_GTPASES_ACTIVATE_ROCKS": "RHO GTPases Activate ROCKs", "REACTOME_RHO_GTPASES_ACTIVATE_RHOTEKIN_AND_RHOPHILINS": "RHO GTPases Activate Rhotekin and Rhophilins", "REACTOME_RHO_GTPASES_ACTIVATE_PKNS": "RHO GTPases activate PKNs", "REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES": "RHO GTPases Activate WASPs and WAVEs", "REACTOME_RIBAVIRIN_ADME": "Ribavirin ADME", "REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_ZBP1": "RIP-mediated NFkB activation via ZBP1", "REACTOME_RHO_GTPASE_CYCLE": "RHO GTPase cycle", "REACTOME_RIPK1_MEDIATED_REGULATED_NECROSIS": "RIPK1-mediated regulated necrosis", "REACTOME_RNA_POLYMERASE_III_CHAIN_ELONGATION": "RNA Polymerase III Chain Elongation", "REACTOME_RMTS_METHYLATE_HISTONE_ARGININES": "RMTs methylate histone arginines", "REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION": "RNA Polymerase III Transcription", "REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_1_PROMOTER": "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "REACTOME_RHO_GTPASE_EFFECTORS": "RHO GTPase Effectors", "REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_TERMINATION": "RNA Polymerase III Transcription Termination", "REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER": "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS": "RNA Polymerase II Pre-transcription Events", "REACTOME_RNA_POLYMERASE_II_TRANSCRIBES_SNRNA_GENES": "RNA polymerase II transcribes snRNA genes", "REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION": "RNA Polymerase II Transcription Termination", "REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE": "RNA Polymerase I Promoter Escape", "REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION": "RNA Polymerase I Transcription", "REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_TERMINATION": "RNA Polymerase I Transcription Termination", "REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION": "RNA Polymerase I Transcription Initiation", "REACTOME_RND1_GTPASE_CYCLE": "RND1 GTPase cycle", "REACTOME_RND2_GTPASE_CYCLE": "RND2 GTPase cycle", "REACTOME_ROBO_RECEPTORS_BIND_AKAP5": "ROBO receptors bind AKAP5", "REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION": "RNA Polymerase II Transcription", "REACTOME_ROLE_OF_ABL_IN_ROBO_SLIT_SIGNALING": "Role of ABL in ROBO-SLIT signaling", "REACTOME_RND3_GTPASE_CYCLE": "RND3 GTPase cycle", "REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING": "Role of second messengers in netrin-1 signaling", "REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION": "Role of LAT2/NTAL/LAB on calcium mobilization", "REACTOME_RORA_ACTIVATES_GENE_EXPRESSION": "", "REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS": "Role of phospholipids in phagocytosis", "REACTOME_RRNA_MODIFICATION_IN_THE_MITOCHONDRION": "rRNA modification in the mitochondrion", "REACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES": "ROS and RNS production in phagocytes", "REACTOME_RRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL": "rRNA modification in the nucleus and cytosol", "REACTOME_RRNA_PROCESSING_IN_THE_MITOCHONDRION": "rRNA processing in the mitochondrion", "REACTOME_RSK_ACTIVATION": "RSK activation", "REACTOME_RRNA_PROCESSING": "rRNA processing", "REACTOME_RSV_HOST_INTERACTIONS": "RSV-host interactions", "REACTOME_RUNX1_AND_FOXP3_CONTROL_THE_DEVELOPMENT_OF_REGULATORY_T_LYMPHOCYTES_TREGS": "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN": "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "REACTOME_RUNX1_REGULATES_EXPRESSION_OF_COMPONENTS_OF_TIGHT_JUNCTIONS": "RUNX1 regulates expression of components of tight junctions", "REACTOME_RUNX1_REGULATES_ESTROGEN_RECEPTOR_MEDIATED_TRANSCRIPTION": "RUNX1 regulates estrogen receptor mediated transcription", "REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_BCR_SIGNALING": "RUNX1 regulates transcription of genes involved in BCR signaling", "REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_KERATINOCYTES": "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION": "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS": "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_INTERLEUKIN_SIGNALING": "RUNX1 regulates transcription of genes involved in interleukin signaling", "REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_MYELOID_CELLS": "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_WNT_SIGNALING": "RUNX1 regulates transcription of genes involved in WNT signaling", "REACTOME_RUNX2_REGULATES_GENES_INVOLVED_IN_CELL_MIGRATION": "RUNX2 regulates genes involved in cell migration", "REACTOME_RUNX2_REGULATES_CHONDROCYTE_MATURATION": "RUNX2 regulates chondrocyte maturation", "REACTOME_RUNX2_REGULATES_BONE_DEVELOPMENT": "RUNX2 regulates bone development", "REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION": "RUNX3 regulates BCL2L11 (BIM) transcription", "REACTOME_RUNX2_REGULATES_OSTEOBLAST_DIFFERENTIATION": "RUNX2 regulates osteoblast differentiation", "REACTOME_RUNX3_REGULATES_IMMUNE_RESPONSE_AND_CELL_MIGRATION": "RUNX3 Regulates Immune Response and Cell Migration", "REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION": "RUNX3 regulates CDKN1A transcription", "REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING": "RUNX3 regulates NOTCH signaling", "REACTOME_RUNX3_REGULATES_P14_ARF": "RUNX3 regulates p14-ARF", "REACTOME_RUNX3_REGULATES_WNT_SIGNALING": "RUNX3 regulates WNT signaling", "REACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION": "RUNX3 regulates YAP1-mediated transcription", "REACTOME_SARS_COV_1_ACTIVATES_MODULATES_INNATE_IMMUNE_RESPONSES": "SARS-CoV-1 activates/modulates innate immune responses", "REACTOME_SARS_COV_1_HOST_INTERACTIONS": "SARS-CoV-1-host interactions", "REACTOME_SARS_COV_1_MODULATES_HOST_TRANSLATION_MACHINERY": "SARS-CoV-1 modulates host translation machinery", "REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS": "SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "REACTOME_SARS_COV_2_MODULATES_AUTOPHAGY": "SARS-CoV-2 modulates autophagy", "REACTOME_SARS_COV_1_INFECTION": "SARS-CoV-1 Infection", "REACTOME_SARS_COV_2_HOST_INTERACTIONS": "SARS-CoV-2-host interactions", "REACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES": "SARS-CoV-2 activates/modulates innate and adaptive immune responses", "REACTOME_SARS_COV_2_MODULATES_HOST_TRANSLATION_MACHINERY": "SARS-CoV-2 modulates host translation machinery", "REACTOME_SARS_COV_2_TARGETS_PDZ_PROTEINS_IN_CELL_CELL_JUNCTION": "SARS-CoV-2 targets PDZ proteins in cell-cell junction", "REACTOME_SARS_COV_2_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS": "SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "REACTOME_SARS_COV_2_INFECTION": "SARS-CoV-2 Infection", "REACTOME_SCAVENGING_BY_CLASS_A_RECEPTORS": "Scavenging by Class A Receptors", "REACTOME_SCAVENGING_BY_CLASS_F_RECEPTORS": "Scavenging by Class F Receptors", "REACTOME_SCAVENGING_BY_CLASS_B_RECEPTORS": "Scavenging by Class B Receptors", "REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1": "SCF-beta-TrCP mediated degradation of Emi1", "REACTOME_SCAVENGING_OF_HEME_FROM_PLASMA": "Scavenging of heme from plasma", "REACTOME_SARS_COV_INFECTIONS": "SARS-CoV Infections", "REACTOME_SEALING_OF_THE_NUCLEAR_ENVELOPE_NE_BY_ESCRT_III": "Sealing of the nuclear envelope (NE) by ESCRT-III", "REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION": "Sema3A PAK dependent Axon repulsion", "REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21": "SCF(Skp2)-mediated degradation of p27/p21", "REACTOME_SELENOAMINO_ACID_METABOLISM": "Selenoamino acid metabolism", "REACTOME_SELECTIVE_AUTOPHAGY": "Selective autophagy", "REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE": "Sema4D induced cell migration and growth-cone collapse", "REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING": "Sema4D in semaphorin signaling", "REACTOME_SEMA4D_MEDIATED_INHIBITION_OF_CELL_ATTACHMENT_AND_MIGRATION": "Sema4D mediated inhibition of cell attachment and migration", "REACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS": "Sensing of DNA Double Strand Breaks", "REACTOME_SENSORY_PERCEPTION_OF_SALTY_TASTE": "Sensory perception of salty taste", "REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP": "Senescence-Associated Secretory Phenotype (SASP)", "REACTOME_SEMAPHORIN_INTERACTIONS": "Semaphorin interactions", "REACTOME_SENSORY_PROCESSING_OF_SOUND": "Sensory processing of sound", "REACTOME_SENSORY_PROCESSING_OF_SOUND_BY_OUTER_HAIR_CELLS_OF_THE_COCHLEA": "Sensory processing of sound by outer hair cells of the cochlea", "REACTOME_SENSORY_PERCEPTION_OF_TASTE": "Sensory perception of taste", "REACTOME_SERINE_BIOSYNTHESIS": "", "REACTOME_SEROTONIN_AND_MELATONIN_BIOSYNTHESIS": "Serotonin and melatonin biosynthesis", "REACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE": "Serotonin Neurotransmitter Release Cycle", "REACTOME_SEPARATION_OF_SISTER_CHROMATIDS": "Separation of Sister Chromatids", "REACTOME_SEROTONIN_RECEPTORS": "Serotonin receptors", "REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING": "SHC1 events in EGFR signaling", "REACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING": "SHC1 events in ERBB2 signaling", "REACTOME_SHC_MEDIATED_CASCADE_FGFR1": "SHC-mediated cascade:FGFR1", "REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING": "SHC1 events in ERBB4 signaling", "REACTOME_SENSORY_PERCEPTION": "Sensory Perception", "REACTOME_SHC_MEDIATED_CASCADE_FGFR3": "SHC-mediated cascade:FGFR3", "REACTOME_SHC_MEDIATED_CASCADE_FGFR4": "SHC-mediated cascade:FGFR4", "REACTOME_SHC_RELATED_EVENTS_TRIGGERED_BY_IGF1R": "SHC-related events triggered by IGF1R", "REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1": "Signaling by activated point mutants of FGFR1", "REACTOME_SIALIC_ACID_METABOLISM": "Sialic acid metabolism", "REACTOME_SIGNALING_BY_ACTIVIN": "Signaling by Activin", "REACTOME_SIGNALING_BY_ALK": "Signaling by ALK", "REACTOME_SIGNALING_BY_ALK_IN_CANCER": "Signaling by ALK in cancer", "REACTOME_SIGNALING_BY_BMP": "Signaling by BMP", "REACTOME_SIGNALING_BY_CSF1_M_CSF_IN_MYELOID_CELLS": "Signaling by CSF1 (M-CSF) in myeloid cells", "REACTOME_SIGNALING_BY_CSF3_G_CSF": "Signaling by CSF3 (G-CSF)", "REACTOME_SIGNALING_BY_BRAF_AND_RAF1_FUSIONS": "Signaling by BRAF and RAF1 fusions", "REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS": "Signaling by CTNNB1 phospho-site mutants", "REACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS": "Signaling by cytosolic FGFR1 fusion mutants", "REACTOME_SIGNALING_BY_EGFR_IN_CANCER": "Signaling by EGFR in Cancer", "REACTOME_SIGNALING_BY_EGFR": "Signaling by EGFR", "REACTOME_SIGNALING_BY_ERBB2": "Signaling by ERBB2", "REACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS": "Signaling by ERBB2 ECD mutants", "REACTOME_SIGNALING_BY_ERBB2_IN_CANCER": "Signaling by ERBB2 in Cancer", "REACTOME_SIGNALING_BY_ERBB4": "Signaling by ERBB4", "REACTOME_SIGNALING_BY_ERYTHROPOIETIN": "Signaling by Erythropoietin", "REACTOME_SIGNALING_BY_FGFR": "Signaling by FGFR", "REACTOME_SIGNALING_BY_FGFR1_IN_DISEASE": "Signaling by FGFR1 in disease", "REACTOME_SIGNALING_BY_FGFR2_IIIA_TM": "Signaling by FGFR2 IIIa TM", "REACTOME_SIGNALING_BY_FGFR1": "Signaling by FGFR1", "REACTOME_SIGNALING_BY_FGFR2": "Signaling by FGFR2", "REACTOME_SIGNALING_BY_FGFR2_IN_DISEASE": "Signaling by FGFR2 in disease", "REACTOME_SIGNALING_BY_FGFR3": "Signaling by FGFR3", "REACTOME_SIGNALING_BY_FGFR4_IN_DISEASE": "Signaling by FGFR4 in disease", "REACTOME_SIGNALING_BY_FGFR4": "Signaling by FGFR4", "REACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS": "Signaling by FLT3 fusion proteins", "REACTOME_SIGNALING_BY_FGFR_IN_DISEASE": "Signaling by FGFR in disease", "REACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS": "Signaling by FLT3 ITD and TKD mutants", "REACTOME_SIGNALING_BY_HIPPO": "Signaling by Hippo", "REACTOME_SIGNALING_BY_HEDGEHOG": "Signaling by Hedgehog", "REACTOME_SIGNALING_BY_INSULIN_RECEPTOR": "Signaling by Insulin receptor", "REACTOME_SIGNALING_BY_GPCR": "Signaling by GPCR", "REACTOME_SIGNALING_BY_LEPTIN": "Signaling by Leptin", "REACTOME_SIGNALING_BY_LRP5_MUTANTS": "Signaling by LRP5 mutants", "REACTOME_SIGNALING_BY_KIT_IN_DISEASE": "Signaling by KIT in disease", "REACTOME_SIGNALING_BY_LTK": "Signaling by LTK", "REACTOME_SIGNALING_BY_LTK_IN_CANCER": "Signaling by LTK in cancer", "REACTOME_SIGNALING_BY_MAPK_MUTANTS": "Signaling by MAPK mutants", "REACTOME_SIGNALING_BY_INTERLEUKINS": "Signaling by Interleukins", "REACTOME_SIGNALING_BY_MEMBRANE_TETHERED_FUSIONS_OF_PDGFRA_OR_PDGFRB": "Signaling by membrane-tethered fusions of PDGFRA or PDGFRB", "REACTOME_SIGNALING_BY_MET": "Signaling by MET", "REACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS": "Signaling by MRAS-complex mutants", "REACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS": "Signaling by moderate kinase activity BRAF mutants", "REACTOME_SIGNALING_BY_MST1": "Signaling by MST1", "REACTOME_SIGNALING_BY_NODAL": "Signaling by NODAL", "REACTOME_SIGNALING_BY_NOTCH1": "Signaling by NOTCH1", "REACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER": "Signaling by NOTCH1 HD Domain Mutants in Cancer", "REACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT": "Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER": "Signaling by NOTCH1 PEST Domain Mutants in Cancer", "REACTOME_SIGNALING_BY_NOTCH": "Signaling by NOTCH", "REACTOME_SIGNALING_BY_NOTCH2": "Signaling by NOTCH2", "REACTOME_SIGNALING_BY_NOTCH3": "Signaling by NOTCH3", "REACTOME_SIGNALING_BY_NOTCH4": "Signaling by NOTCH4", "REACTOME_SIGNALING_BY_NTRK3_TRKC": "Signaling by NTRK3 (TRKC)", "REACTOME_SIGNALING_BY_NTRK2_TRKB": "Signaling by NTRK2 (TRKB)", "REACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS": "Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "REACTOME_SIGNALING_BY_NTRKS": "Signaling by NTRKs", "REACTOME_SIGNALING_BY_PDGFR_IN_DISEASE": "Signaling by PDGFR in disease", "REACTOME_SIGNALING_BY_PDGF": "Signaling by PDGF", "REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS": "Signaling by Nuclear Receptors", "REACTOME_SIGNALING_BY_PTK6": "Signaling by PTK6", "REACTOME_SIGNALING_BY_RNF43_MUTANTS": "Signaling by RNF43 mutants", "REACTOME_SIGNALING_BY_RETINOIC_ACID": "Signaling by Retinoic Acid", "REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3": "Signaling by Rho GTPases, Miro GTPases and RHOBTB3", "REACTOME_SIGNALING_BY_SCF_KIT": "Signaling by SCF-KIT", "REACTOME_SIGNALING_BY_TGFBR3": "Signaling by TGFBR3", "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER": "Signaling by TGF-beta Receptor Complex in Cancer", "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX": "Signaling by TGF-beta Receptor Complex", "REACTOME_SIGNALING_BY_ROBO_RECEPTORS": "Signaling by ROBO receptors", "REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS": "Signaling by TGFB family members", "REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES": "Signaling by Receptor Tyrosine Kinases", "REACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R": "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR": "Signaling by the B Cell Receptor (BCR)", "REACTOME_SIGNALING_BY_VEGF": "Signaling by VEGF", "REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN": "Signalling to p38 via RIT and RIN", "REACTOME_SIGNALING_BY_WNT_IN_CANCER": "Signaling by WNT in cancer", "REACTOME_SIGNALLING_TO_RAS": "Signalling to RAS", "REACTOME_SIGNAL_ATTENUATION": "Signal attenuation", "REACTOME_SIGNALLING_TO_ERKS": "Signalling to ERKs", "REACTOME_SIGNAL_TRANSDUCTION_BY_L1": "Signal transduction by L1", "REACTOME_SIGNALING_BY_WNT": "Signaling by WNT", "REACTOME_SIGNAL_REGULATORY_PROTEIN_FAMILY_INTERACTIONS": "Signal regulatory protein family interactions", "REACTOME_SIGNAL_AMPLIFICATION": "Signal amplification", "REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION": "SIRT1 negatively regulates rRNA expression", "REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS": "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "REACTOME_SLC15A4_TASL_DEPENDENT_IRF5_ACTIVATION": "SLC15A4:TASL-dependent IRF5 activation", "REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS": "Small interfering RNA (siRNA) biogenesis", "REACTOME_SMAC_XIAP_REGULATED_APOPTOTIC_RESPONSE": "SMAC, XIAP-regulated apoptotic response", "REACTOME_SODIUM_CALCIUM_EXCHANGERS": "Sodium/Calcium exchangers", "REACTOME_SLC_TRANSPORTER_DISORDERS": "SLC transporter disorders", "REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT": "SLC-mediated transmembrane transport", "REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "REACTOME_SNRNP_ASSEMBLY": "snRNP Assembly", "REACTOME_SMOOTH_MUSCLE_CONTRACTION": "Smooth Muscle Contraction", "REACTOME_SODIUM_COUPLED_PHOSPHATE_COTRANSPORTERS": "Sodium-coupled phosphate cotransporters", "REACTOME_SODIUM_COUPLED_SULPHATE_DI_AND_TRI_CARBOXYLATE_TRANSPORTERS": "", "REACTOME_SODIUM_PROTON_EXCHANGERS": "Sodium/Proton exchangers", "REACTOME_SOMITOGENESIS": "Somitogenesis", "REACTOME_SOS_MEDIATED_SIGNALLING": "SOS-mediated signalling", "REACTOME_SPECIFICATION_OF_PRIMORDIAL_GERM_CELLS": "Specification of primordial germ cells", "REACTOME_SPECIFICATION_OF_THE_NEURAL_PLATE_BORDER": "Specification of the neural plate border", "REACTOME_SPHINGOLIPID_CATABOLISM": "Sphingolipid catabolism", "REACTOME_SPERM_MOTILITY_AND_TAXES": "Sperm Motility And Taxes", "REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS": "Sphingolipid de novo biosynthesis", "REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING": "Spry regulation of FGF signaling", "REACTOME_STABILIZATION_OF_P53": "Stabilization of p53", "REACTOME_SPHINGOLIPID_METABOLISM": "Sphingolipid metabolism", "REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE": "SRP-dependent cotranslational protein targeting to membrane", "REACTOME_STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING": "STAT3 nuclear events downstream of ALK signaling", "REACTOME_STAT5_ACTIVATION": "STAT5 Activation", "REACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS": "STAT5 activation downstream of FLT3 ITD mutants", "REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES": "STING mediated induction of host immune responses", "REACTOME_STIMULI_SENSING_CHANNELS": "Stimuli-sensing channels", "REACTOME_SULFIDE_OXIDATION_TO_SULFATE": "Sulfide oxidation to sulfate", "REACTOME_STRIATED_MUSCLE_CONTRACTION": "Striated Muscle Contraction", "REACTOME_SULFUR_AMINO_ACID_METABOLISM": "Sulfur amino acid metabolism", "REACTOME_SUMOYLATION_OF_DNA_METHYLATION_PROTEINS": "SUMOylation of DNA methylation proteins", "REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS": "SUMOylation of chromatin organization proteins", "REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS": "SUMOylation of DNA damage response and repair proteins", "REACTOME_SUMOYLATION": "SUMOylation", "REACTOME_SUMOYLATION_OF_IMMUNE_RESPONSE_PROTEINS": "SUMOylation of immune response proteins", "REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS": "SUMOylation of DNA replication proteins", "REACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS": "SUMOylation of intracellular receptors", "REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS": "SUMOylation of RNA binding proteins", "REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS": "SUMOylation of SUMOylation proteins", "REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS": "SUMOylation of transcription factors", "REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS": "SUMOylation of transcription cofactors", "REACTOME_SUMO_IS_CONJUGATED_TO_E1_UBA2_SAE1": "SUMO is conjugated to E1 (UBA2:SAE1)", "REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS": "SUMOylation of ubiquitinylation proteins", "REACTOME_SUPPRESSION_OF_APOPTOSIS": "Suppression of apoptosis", "REACTOME_SUMO_IS_TRANSFERRED_FROM_E1_TO_E2_UBE2I_UBC9": "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "REACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED": "SUMO is proteolytically processed", "REACTOME_SUPPRESSION_OF_PHAGOSOMAL_MATURATION": "Suppression of phagosomal maturation", "REACTOME_SURFACTANT_METABOLISM": "Surfactant metabolism", "REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES": "Synaptic adhesion-like molecules", "REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES": "Synthesis of 12-eicosatetraenoic acid derivatives", "REACTOME_SYNDECAN_INTERACTIONS": "Syndecan interactions", "REACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE": "Switching of origins to a post-replicative state", "REACTOME_SYNTHESIS_OF_15_EICOSATETRAENOIC_ACID_DERIVATIVES": "Synthesis of 15-eicosatetraenoic acid derivatives", "REACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "REACTOME_SYNTHESIS_OF_5_EICOSATETRAENOIC_ACIDS": "Synthesis of 5-eicosatetraenoic acids", "REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS": "Synthesis of bile acids and bile salts", "REACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES": "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL": "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL": "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "REACTOME_SYNTHESIS_OF_DIPHTHAMIDE_EEF2": "Synthesis of diphthamide-EEF2", "REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "REACTOME_SYNTHESIS_OF_DOLICHYL_PHOSPHATE": "Synthesis of dolichyl-phosphate", "REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI": "Synthesis of glycosylphosphatidylinositol (GPI)", "REACTOME_SYNTHESIS_OF_DNA": "Synthesis of DNA", "REACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET": "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "REACTOME_SYNTHESIS_OF_GDP_MANNOSE": "Synthesis of GDP-mannose", "REACTOME_SYNTHESIS_OF_IP2_IP_AND_INS_IN_THE_CYTOSOL": "Synthesis of IP2, IP, and Ins in the cytosol", "REACTOME_SYNTHESIS_OF_KETONE_BODIES": "Synthesis of Ketone Bodies", "REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL": "Synthesis of IP3 and IP4 in the cytosol", "REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX": "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "REACTOME_SYNTHESIS_OF_PA": "Synthesis of PA", "REACTOME_SYNTHESIS_OF_LIPOXINS_LX": "", "REACTOME_SYNTHESIS_OF_PE": "Synthesis of PE", "REACTOME_SYNTHESIS_OF_PG": "Synthesis of PG", "REACTOME_SYNTHESIS_OF_PIPS_AT_THE_ER_MEMBRANE": "Synthesis of PIPs at the ER membrane", "REACTOME_SYNTHESIS_OF_PI": "Synthesis of PI", "REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE": "Synthesis of PIPs at the early endosome membrane", "REACTOME_SYNTHESIS_OF_PC": "Synthesis of PC", "REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE": "Synthesis of PIPs at the Golgi membrane", "REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE": "Synthesis of PIPs at the late endosome membrane", "REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE": "Synthesis of PIPs at the plasma membrane", "REACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL": "Synthesis of pyrophosphates in the cytosol", "REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS": "Synthesis of substrates in N-glycan biosythesis", "REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS": "Synthesis of very long-chain fatty acyl-CoAs", "REACTOME_SYNTHESIS_OF_UDP_N_ACETYL_GLUCOSAMINE": "Synthesis of UDP-N-acetyl-glucosamine", "REACTOME_SYNTHESIS_OF_WYBUTOSINE_AT_G37_OF_TRNA_PHE": "Synthesis of wybutosine at G37 of tRNA(Phe)", "REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN": "Synthesis, secretion, and deacylation of Ghrelin", "REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLUCOSE_DEPENDENT_INSULINOTROPIC_POLYPEPTIDE_GIP": "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLUCAGON_LIKE_PEPTIDE_1_GLP_1": "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "REACTOME_TACHYKININ_RECEPTORS_BIND_TACHYKININS": "Tachykinin receptors bind tachykinins", "REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS": "Tandem pore domain potassium channels", "REACTOME_S_PHASE": "S Phase", "REACTOME_TAK1_DEPENDENT_IKK_AND_NF_KAPPA_B_ACTIVATION": "TAK1-dependent IKK and NF-kappa-B activation", "REACTOME_TBC_RABGAPS": "TBC/RABGAPs", "REACTOME_TELOMERE_EXTENSION_BY_TELOMERASE": "Telomere Extension By Telomerase", "REACTOME_TELOMERE_C_STRAND_SYNTHESIS_INITIATION": "Telomere C-strand synthesis initiation", "REACTOME_TELOMERE_C_STRAND_LAGGING_STRAND_SYNTHESIS": "Telomere C-strand (Lagging Strand) Synthesis", "REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT": "TCF dependent signaling in response to WNT", "REACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT": "Terminal pathway of complement", "REACTOME_TELOMERE_MAINTENANCE": "Telomere Maintenance", "REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS": "Termination of O-glycan biosynthesis", "REACTOME_TCR_SIGNALING": "TCR signaling", "REACTOME_TERMINATION_OF_TRANSLESION_DNA_SYNTHESIS": "Termination of translesion DNA synthesis", "REACTOME_TFAP2A_ACTS_AS_A_TRANSCRIPTIONAL_REPRESSOR_DURING_RETINOIC_ACID_INDUCED_CELL_DIFFERENTIATION": "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION": "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_FACTORS": "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_GROWTH_FACTORS_AND_THEIR_RECEPTORS": "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "REACTOME_TGFBR3_EXPRESSION": "TGFBR3 expression", "REACTOME_TGFBR3_PTM_REGULATION": "TGFBR3 PTM regulation", "REACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING": "TGFBR3 regulates TGF-beta signaling", "REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS": "TGF-beta receptor signaling activates SMADs", "REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION": "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES": "The activation of arylsulfatases", "REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION": "The canonical retinoid cycle in rods (twilight vision)", "REACTOME_THE_FATTY_ACID_CYCLING_MODEL": "The fatty acid cycling model", "REACTOME_THE_NLRP3_INFLAMMASOME": "The NLRP3 inflammasome", "REACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION": "The retinoid cycle in cones (daylight vision)", "REACTOME_THE_PHOTOTRANSDUCTION_CASCADE": "The phototransduction cascade", "REACTOME_THE_ROLE_OF_GTSE1_IN_G2_M_PROGRESSION_AFTER_G2_CHECKPOINT": "The role of GTSE1 in G2/M progression after G2 checkpoint", "REACTOME_THYROXINE_BIOSYNTHESIS": "Thyroxine biosynthesis", "REACTOME_THE_ROLE_OF_NEF_IN_HIV_1_REPLICATION_AND_DISEASE_PATHOGENESIS": "The role of Nef in HIV-1 replication and disease pathogenesis", "REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR": "Thromboxane signalling through TP receptor", "REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS": "Thrombin signalling through proteinase activated receptors (PARs)", "REACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT": "TICAM1, RIP1-mediated IKK complex recruitment", "REACTOME_TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7": "TICAM1-dependent activation of IRF3/IRF7", "REACTOME_TICAM1_TRAF6_DEPENDENT_INDUCTION_OF_TAK1_COMPLEX": "TICAM1,TRAF6-dependent induction of TAK1 complex", "REACTOME_TIE2_SIGNALING": "Tie2 Signaling", "REACTOME_TIGHT_JUNCTION_INTERACTIONS": "Tight junction interactions", "REACTOME_TLR3_MEDIATED_TICAM1_DEPENDENT_PROGRAMMED_CELL_DEATH": "TLR3-mediated TICAM1-dependent programmed cell death", "REACTOME_TNFR1_MEDIATED_CERAMIDE_PRODUCTION": "TNFR1-mediated ceramide production", "REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING": "TNFR1-induced proapoptotic signaling", "REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY": "TNFR1-induced NF-kappa-B signaling pathway", "REACTOME_TNFR2_NON_CANONICAL_NF_KB_PATHWAY": "TNFR2 non-canonical NF-kB pathway", "REACTOME_TNF_RECEPTOR_SUPERFAMILY_TNFSF_MEMBERS_MEDIATING_NON_CANONICAL_NF_KB_PATHWAY": "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "REACTOME_TNFS_BIND_THEIR_PHYSIOLOGICAL_RECEPTORS": "TNFs bind their physiological receptors", "REACTOME_TNF_SIGNALING": "TNF signaling", "REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE": "Toll Like Receptor 9 (TLR9) Cascade", "REACTOME_TOXICITY_OF_BOTULINUM_TOXIN_TYPE_D_BOTD": "Toxicity of botulinum toxin type D (botD)", "REACTOME_TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE": "Toll Like Receptor TLR1:TLR2 Cascade", "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES": "Toll-like Receptor Cascades", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CASPASE_ACTIVATORS_AND_CASPASES": "TP53 Regulates Transcription of Caspase Activators and Caspases", "REACTOME_TP53_REGULATES_METABOLIC_GENES": "TP53 Regulates Metabolic Genes", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN": "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES": "TP53 Regulates Transcription of Cell Cycle Genes", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DEATH_RECEPTORS_AND_LIGANDS": "TP53 Regulates Transcription of Death Receptors and Ligands", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_DEATH_GENES": "TP53 Regulates Transcription of Cell Death Genes", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES": "TP53 Regulates Transcription of DNA Repair Genes", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST": "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_CYTOCHROME_C_RELEASE": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_SEVERAL_ADDITIONAL_CELL_DEATH_GENES_WHOSE_SPECIFIC_ROLES_IN_P53_DEPENDENT_APOPTOSIS_REMAIN_UNCERTAIN": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G2_CELL_CYCLE_ARREST": "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY": "TRAF3-dependent IRF activation pathway", "REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX_WITHIN_TLR4_COMPLEX": "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING": "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "REACTOME_TRAF6_MEDIATED_NF_KB_ACTIVATION": "TRAF6 mediated NF-kB activation", "REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION": "TRAF6 mediated IRF7 activation", "REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR": "Trafficking and processing of endosomal TLR", "REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS": "Trafficking of GluR2-containing AMPA receptors", "REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS": "Trafficking of AMPA receptors", "REACTOME_TRAIL_SIGNALING": "TRAIL  signaling", "REACTOME_TRAFFICKING_OF_MYRISTOYLATED_PROTEINS_TO_THE_CILIUM": "Trafficking of myristoylated proteins to the cilium", "REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER": "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer", "REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS": "Transcriptional activation of mitochondrial biogenesis", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6": "Transcriptional Regulation by E2F6", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2": "Transcriptional Regulation by MECP2", "REACTOME_TRANSCRIPTIONAL_AND_POST_TRANSLATIONAL_REGULATION_OF_MITF_M_EXPRESSION_AND_ACTIVITY": "Transcriptional and post-translational regulation of MITF-M expression and activity", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4": "Transcriptional Regulation by NPAS4", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX2": "Transcriptional regulation by RUNX2", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS": "Transcriptional regulation by small RNAs", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3": "Transcriptional regulation by RUNX3", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1": "Transcriptional regulation by RUNX1", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS": "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX": "Transcriptional Regulation by VENTX", "REACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION": "Transcriptional regulation of brown and beige adipocyte differentiation", "REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS": "Transcriptional regulation of pluripotent stem cells", "REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS": "Transcriptional regulation of granulopoiesis", "REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53": "Transcriptional Regulation by TP53", "REACTOME_TRANSCRIPTIONAL_REGULATION_OF_TESTIS_DIFFERENTIATION": "Transcriptional regulation of testis differentiation", "REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION": "Transcriptional regulation of white adipocyte differentiation", "REACTOME_TRANSCRIPTION_OF_E2F_TARGETS_UNDER_NEGATIVE_CONTROL_BY_DREAM_COMPLEX": "Transcription of E2F targets under negative control by DREAM complex", "REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER": "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "REACTOME_TRANSCRIPTION_OF_E2F_TARGETS_UNDER_NEGATIVE_CONTROL_BY_P107_RBL1_AND_P130_RBL2_IN_COMPLEX_WITH_HDAC1": "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "REACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME": "Transcription of the HIV genome", "REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING": "Transferrin endocytosis and recycling", "REACTOME_TRANSLATION_OF_SARS_COV_1_STRUCTURAL_PROTEINS": "Translation of Structural Proteins", "REACTOME_TRANSLATION_OF_REPLICASE_AND_ASSEMBLY_OF_THE_REPLICATION_TRANSCRIPTION_COMPLEX": "Translation of Replicase and Assembly of the Replication Transcription Complex", "REACTOME_TRANSLESION_SYNTHESIS_BY_POLH": "Translesion Synthesis by POLH", "REACTOME_TRANSLESION_SYNTHESIS_BY_POLK": "Translesion synthesis by POLK", "REACTOME_TRANSLATION": "Translation", "REACTOME_TRANSLESION_SYNTHESIS_BY_Y_FAMILY_DNA_POLYMERASES_BYPASSES_LESIONS_ON_DNA_TEMPLATE": "Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template", "REACTOME_TRANSLATION_OF_SARS_COV_2_STRUCTURAL_PROTEINS": "Translation of Structural Proteins", "REACTOME_TRANSLOCATION_OF_SLC2A4_GLUT4_TO_THE_PLASMA_MEMBRANE": "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS": "", "REACTOME_TRANSPORT_AND_SYNTHESIS_OF_PAPS": "", "REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES": "Transmission across Chemical Synapses", "REACTOME_TRANSPORT_OF_FATTY_ACIDS": "Transport of fatty acids", "REACTOME_TRANSPORT_OF_CONNEXONS_TO_THE_PLASMA_MEMBRANE": "Transport of connexons to the plasma membrane", "REACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE": "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES": "", "REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS": "Transport of Mature mRNAs Derived from Intronless Transcripts", "REACTOME_TRANSPORT_OF_NUCLEOTIDE_SUGARS": "Transport of nucleotide sugars", "REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM": "Transport of Mature Transcript to Cytoplasm", "REACTOME_TRANSPORT_OF_ORGANIC_ANIONS": "", "REACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY": "Transport of RCbl within the body", "REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES": "Transport of vitamins, nucleosides, and related molecules", "REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA": "Transport of the SLBP Dependant Mature mRNA", "REACTOME_TRIF_MEDIATED_PROGRAMMED_CELL_DEATH": "TRIF-mediated programmed cell death", "REACTOME_TRIGLYCERIDE_BIOSYNTHESIS": "Triglyceride biosynthesis", "REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING": "trans-Golgi Network Vesicle Budding", "REACTOME_TRIGLYCERIDE_CATABOLISM": "Triglyceride catabolism", "REACTOME_TRISTETRAPROLIN_TTP_ZFP36_BINDS_AND_DESTABILIZES_MRNA": "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "REACTOME_TRANSPORT_OF_SMALL_MOLECULES": "Transport of small molecules", "REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION": "Transport to the Golgi and subsequent modification", "REACTOME_TRIGLYCERIDE_METABOLISM": "Triglyceride metabolism", "REACTOME_TRNA_MODIFICATION_IN_THE_MITOCHONDRION": "tRNA modification in the mitochondrion", "REACTOME_TRNA_AMINOACYLATION": "tRNA Aminoacylation", "REACTOME_TRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL": "tRNA modification in the nucleus and cytosol", "REACTOME_TRNA_PROCESSING_IN_THE_MITOCHONDRION": "tRNA processing in the mitochondrion", "REACTOME_TRP_CHANNELS": "TRP channels", "REACTOME_TRNA_PROCESSING": "tRNA processing", "REACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY": "Type I hemidesmosome assembly", "REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS": "tRNA processing in the nucleus", "REACTOME_TRYPTOPHAN_CATABOLISM": "Tryptophan catabolism", "REACTOME_TYROSINE_CATABOLISM": "Tyrosine catabolism", "REACTOME_TYSND1_CLEAVES_PEROXISOMAL_PROTEINS": "TYSND1 cleaves peroxisomal proteins", "REACTOME_UBIQUINOL_BIOSYNTHESIS": "Ubiquinol biosynthesis", "REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION": "Unblocking of NMDA receptors, glutamate binding and activation", "REACTOME_UCH_PROTEINASES": "UCH proteinases", "REACTOME_UNWINDING_OF_DNA": "Unwinding of DNA", "REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES": "Ub-specific processing proteases", "REACTOME_UPTAKE_AND_ACTIONS_OF_BACTERIAL_TOXINS": "Uptake and actions of bacterial toxins", "REACTOME_UPTAKE_AND_FUNCTION_OF_ANTHRAX_TOXINS": "Uptake and function of anthrax toxins", "REACTOME_UPTAKE_AND_FUNCTION_OF_DIPHTHERIA_TOXIN": "Uptake and function of diphtheria toxin", "REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR": "Unfolded Protein Response (UPR)", "REACTOME_UPTAKE_OF_DIETARY_COBALAMINS_INTO_ENTEROCYTES": "Uptake of dietary cobalamins into enterocytes", "REACTOME_UREA_CYCLE": "Urea cycle", "REACTOME_VASOPRESSIN_LIKE_RECEPTORS": "Vasopressin-like receptors", "REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY": "VEGFR2 mediated vascular permeability", "REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS": "Vasopressin regulates renal water homeostasis via Aquaporins", "REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION": "VEGFR2 mediated cell proliferation", "REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS": "VEGF ligand-receptor interactions", "REACTOME_VITAMINS": "Vitamins", "REACTOME_VITAMIN_B1_THIAMIN_METABOLISM": "Vitamin B1 (thiamin) metabolism", "REACTOME_VISUAL_PHOTOTRANSDUCTION": "Visual phototransduction", "REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS": "Viral Messenger RNA Synthesis", "REACTOME_VITAMIN_B2_RIBOFLAVIN_METABOLISM": "Vitamin B2 (riboflavin) metabolism", "REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM": "Vitamin B5 (pantothenate) metabolism", "REACTOME_VITAMIN_C_ASCORBATE_METABOLISM": "Vitamin C (ascorbate) metabolism", "REACTOME_VITAMIN_D_CALCIFEROL_METABOLISM": "Vitamin D (calciferol) metabolism", "REACTOME_VIRAL_INFECTION_PATHWAYS": "Viral Infection Pathways", "REACTOME_VESICLE_MEDIATED_TRANSPORT": "Vesicle-mediated transport", "REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION": "VLDLR internalisation and degradation", "REACTOME_VLDL_ASSEMBLY": "VLDL assembly", "REACTOME_VLDL_CLEARANCE": "VLDL clearance", "REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS": "Voltage gated Potassium channels", "REACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS": "Wax and plasmalogen biosynthesis", "REACTOME_VXPX_CARGO_TARGETING_TO_CILIUM": "VxPx cargo-targeting to cilium", "REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4": "WNT5A-dependent internalization of FZD4", "REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2": "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING": "WNT ligand biogenesis and trafficking", "REACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL": "WNT mediated activation of DVL", "REACTOME_XENOBIOTICS": "Xenobiotics", "REACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS": "ZBP1(DAI) mediated induction of type I IFNs", "REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION": "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "REACTOME_ZINC_EFFLUX_AND_COMPARTMENTALIZATION_BY_THE_SLC30_FAMILY": "Zinc efflux and compartmentalization by the SLC30 family", "REACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY": "Zinc influx into cells by the SLC39 gene family", "REACTOME_Z_DECAY_DEGRADATION_OF_MATERNAL_MRNAS_BY_ZYGOTICALLY_EXPRESSED_FACTORS": "Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "REACTOME_ZINC_TRANSPORTERS": "Zinc transporters", "REACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA": "Zygotic genome activation (ZGA)", "WP_10Q1121Q1123_COPY_NUMBER_VARIATION_SYNDROME": "10q11.21q11.23 copy number variation syndrome", "WP_15Q112_COPY_NUMBER_VARIATION_SYNDROME": "15q11.2 copy number variation syndrome", "WP_13Q1212_COPY_NUMBER_VARIATION": "13q12.12 copy number variation", "WP_10Q22Q23_COPY_NUMBER_VARIATION": "10q22q23 copy number variation", "WP_11P112_COPY_NUMBER_VARIATION_SYNDROME": "11p11.2 copy number variation syndrome", "WP_15Q133_COPY_NUMBER_VARIATION_SYNDROME": "15q13.3 copy number variation syndrome", "WP_15Q11Q13_COPY_NUMBER_VARIATION": "15q11q13 copy number variation", "WP_16P112_DISTAL_DELETION_SYNDROME": "16p11.2 distal deletion syndrome", "WP_15Q25_COPY_NUMBER_VARIATION": "15q25 copy number variation", "WP_17P133_YWHAE_COPY_NUMBER_VARIATION": "17p13.3 (YWHAE) copy number variation", "WP_16P112_PROXIMAL_DELETION_SYNDROME": "16p11.2 proximal deletion syndrome", "WP_1Q211_COPY_NUMBER_VARIATION_SYNDROME": "1q21.1 copy number variation syndrome", "WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME": "17q12 copy number variation syndrome", "WP_2Q112_COPY_NUMBER_VARIATION_SYNDROME": "2q11.2 copy number variation syndrome", "WP_22Q112_COPY_NUMBER_VARIATION_SYNDROME": "22q11.2 copy number variation syndrome", "WP_1P36_COPY_NUMBER_VARIATION_SYNDROME": "1p36 copy number variation syndrome", "WP_2Q211_COPY_NUMBER_VARIATION_SYNDROME": "2q21.1 copy number variation syndrome", "WP_2Q13_COPY_NUMBER_VARIATION_SYNDROME": "2q13 copy number variation syndrome", "WP_4HYDROXYTAMOXIFEN_DEXAMETHASONE_AND_RETINOIC_ACIDS_REGULATION_OF_P27_EXPRESSION": "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression", "WP_3Q29_COPY_NUMBER_VARIATION_SYNDROME": "3q29 copy number variation syndrome", "WP_2Q37_COPY_NUMBER_VARIATION_SYNDROME": "2q37 copy number variation syndrome", "WP_6Q16_COPY_NUMBER_VARIATION": "6q16 copy number variation", "WP_4P163_COPY_NUMBER_VARIATION": "4p16.3 copy number variation", "WP_7OXOC_AND_7BETAHC_PATHWAYS": "7-oxo-C and 7-beta-HC pathways", "WP_5Q35_COPY_NUMBER_VARIATION": "5q35 copy number variation", "WP_7Q1123_COPY_NUMBER_VARIATION_SYNDROME": "7q11.23 copy number variation syndrome", "WP_7Q1123_DISTAL_COPY_NUMBER_VARIATION": "7q11.23 distal copy number variation", "WP_8P231_COPY_NUMBER_VARIATION_SYNDROME": "8p23.1 copy number variation syndrome", "WP_ACETAMINOPHEN_IN_ANALGESIA_AND_ANTIPYRESIS": "Acetaminophen in analgesia and antipyresis", "WP_8Q1123_RB1CC1_COPY_NUMBER_VARIATION": "8q11.23 (RB1CC1) copy number variation", "WP_ACETYLCHOLINE_SYNTHESIS": "Acetylcholine synthesis", "WP_ACE_INHIBITOR_PATHWAY": "ACE inhibitor pathway", "WP_ACQUIRED_PARTIAL_LIPODYSTROPHY_BARRAQUERSIMONS_SYNDROME": "Acquired partial lipodystrophy / Barraquer-Simons syndrome", "WP_ACTIVATION_OF_NLRP3_INFLAMMASOME_BY_SARSCOV2": "Activation of NLRP3 inflammasome by SARS-CoV-2", "WP_ACUTE_MYELOID_LEUKEMIA": "Acute myeloid leukemia", "WP_ADHD_AND_AUTISM_ASD_PATHWAYS": "", "WP_AEROBIC_GLYCOLYSIS": "", "WP_ACUTE_VIRAL_MYOCARDITIS": "Acute viral myocarditis", "WP_AEROBIC_GLYCOLYSIS_AUGMENTED": "Aerobic glycolysis - augmented", "WP_ADIPOGENESIS": "Adipogenesis", "WP_AFLATOXIN_B1_METABOLISM": "Aflatoxin B1 metabolism", "WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY": "Affected pathways in Duchenne muscular dystrophy", "WP_AIRWAY_SMOOTH_MUSCLE_CELL_CONTRACTION": "Airway smooth muscle cell contraction", "WP_AGERAGE_PATHWAY": "AGE/RAGE pathway", "WP_ALANINE_AND_ASPARTATE_METABOLISM": "Alanine and aspartate metabolism", "WP_ALSTROM_SYNDROME": "Alstrom syndrome", "WP_ALLOGRAFT_REJECTION": "Allograft rejection", "WP_ALTERNATIVE_PATHWAY_OF_FETAL_ANDROGEN_SYNTHESIS": "Alternative pathway of fetal androgen synthesis", "WP_ALTERED_GLYCOSYLATION_OF_MUC1_IN_TUMOR_MICROENVIRONMENT": "Altered glycosylation of MUC1 in tumor microenvironment", "WP_ALPHA_6_BETA_4_SIGNALING": "Alpha 6 beta 4 signaling", "WP_AMINO_ACID_METABOLISM_IN_TRIPLENEGATIVE_BREAST_CANCER_CELLS": "Amino acid metabolism in triple-negative breast cancer cells", "WP_AMINO_ACID_METABOLISM_PATHWAY_EXCERPT_HISTIDINE_CATABOLISM_EXTENSION": "Amino acid metabolism pathway excerpt: histidine catabolism extension", "WP_AMINO_ACID_METABOLISM": "Amino acid metabolism", "WP_ALZHEIMERS_DISEASE": "Alzheimer's disease", "WP_AMINO_ACID_TRANSPORT_DEFECTS_IEMS": "Amino acid transport defects (IEMs)", "WP_ALZHEIMERS_DISEASE_AND_MIRNA_EFFECTS": "Alzheimer's disease and miRNA effects", "WP_AMPLIFICATION_AND_EXPANSION_OF_ONCOGENIC_PATHWAYS_AS_METASTATIC_TRAITS": "Amplification and expansion of oncogenic pathways as metastatic traits", "WP_AMPACTIVATED_PROTEIN_KINASE_SIGNALING": "AMP-activated protein kinase signaling", "WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER": "Androgen receptor network in prostate cancer", "WP_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS": "Amyotrophic lateral sclerosis (ALS)", "WP_ANGIOGENESIS": "Angiogenesis", "WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY": "Angiotensin II receptor type 1 pathway", "WP_ANDROGEN_RECEPTOR_SIGNALING": "Androgen receptor signaling", "WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY": "Angiopoietin-like protein 8 regulatory pathway", "WP_APOE_AND_MIR146_IN_INFLAMMATION_AND_ATHEROSCLEROSIS": "ApoE and miR-146 in inflammation and atherosclerosis", "WP_ANTIVIRAL_AND_ANTIINFLAMMATORY_EFFECTS_OF_NRF2_ON_SARSCOV2_PATHWAY": "Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway", "WP_APOPTOSIS": "Apoptosis", "WP_APOPTOSIS_MODULATION_BY_HSP70": "Apoptosis modulation by HSP70", "WP_ARACHIDONATE_EPOXYGENASE_EPOXIDE_HYDROLASE": "Arachidonate epoxygenase / epoxide hydrolase", "WP_APOPTOSISRELATED_NETWORK_DUE_TO_ALTERED_NOTCH3_IN_OVARIAN_CANCER": "Apoptosis-related network due to altered Notch3 in ovarian cancer", "WP_APOPTOSIS_MODULATION_AND_SIGNALING": "Apoptosis modulation and signaling", "WP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY": "Arrhythmogenic right ventricular cardiomyopathy", "WP_ARSENIC_METABOLISM_AND_REACTIVE_OXYGEN_SPECIES_GENERATION": "Arsenic metabolism and reactive oxygen species generation", "WP_ARYLAMINE_METABOLISM": "Arylamine metabolism", "WP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2873": "Aryl hydrocarbon receptor pathway", "WP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2586": "Aryl hydrocarbon receptor pathway", "WP_ASPIRIN_AND_MIRNAS": "Aspirin and miRNAs", "WP_ATR_SIGNALING": "ATR signaling", "WP_ATM_SIGNALING": "ATM signaling", "WP_AUTOPHAGY": "Autophagy", "WP_ATM_SIGNALING_IN_DEVELOPMENT_AND_DISEASE": "ATM signaling in development and disease", "WP_AUTOPHAGY_IN_PANCREATIC_DUCTAL_ADENOCARCINOMA": "Autophagy in pancreatic ductal adenocarcinoma", "WP_AUTOSOMAL_RECESSIVE_OSTEOPETROSIS_PATHWAYS": "Autosomal recessive osteopetrosis pathways", "WP_AXON_GUIDANCE": "Axon guidance", "WP_BASE_EXCISION_REPAIR": "Base excision repair", "WP_BARDETBIEDL_SYNDROME": "Bardet-Biedl syndrome", "WP_BENZENE_METABOLISM": "Benzene metabolism", "WP_BDNFTRKB_SIGNALING": "BDNF-TrkB signaling", "WP_BENZOAPYRENE_METABOLISM": "Benzo(a)pyrene metabolism", "WP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION": "Bile acid synthesis and enterohepatic circulation", "WP_BIOGENIC_AMINE_SYNTHESIS": "Biogenic amine synthesis", "WP_BIOMARKERS_FOR_UREA_CYCLE_DISORDERS": "Biomarkers for urea cycle disorders", "WP_BIOMARKERS_FOR_PYRIMIDINE_METABOLISM_DISORDERS": "Biomarkers for pyrimidine metabolism disorders", "WP_BIOSYNTHESIS_AND_REGENERATION_OF_TETRAHYDROBIOPTERIN_AND_CATABOLISM_OF_PHENYLALANINE": "Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine", "WP_BIOSYNTHESIS_AND_TURNOVER_OF_1DEOXYSPHINGOID_BASES": "Biosynthesis and turnover of 1-deoxy-sphingoid bases", "WP_BIOTIN_METABOLISM_INCLUDING_IMDS": "Biotin metabolism, including IMDs", "WP_BLOOD_CLOTTING_CASCADE": "Blood clotting cascade", "WP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT": "BMP signaling in eyelid development", "WP_BLADDER_CANCER": "Bladder cancer", "WP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION": "BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation", "WP_BONE_MORPHOGENIC_PROTEIN_SIGNALING_AND_REGULATION": "Bone morphogenic protein signaling and regulation", "WP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS": "Calcium mediated T-cell apoptosis involved in inclusion body myositis", "WP_B_CELL_RECEPTOR_SIGNALING": "B cell receptor signaling", "WP_BREAST_CANCER_PATHWAY": "Breast cancer pathway", "WP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING": "Brain-derived neurotrophic factor (BDNF) signaling", "WP_BURN_WOUND_HEALING": "Burn wound healing", "WP_CALORIC_RESTRICTION_AND_AGING": "Caloric restriction and aging", "WP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE": "Cancer immunotherapy by CTLA4 blockade", "WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS": "Calcium regulation in cardiac cells", "WP_CAMKK2_PATHWAY": "CAMKK2 pathway", "WP_CANCER_IMMUNOTHERAPY_BY_PD1_BLOCKADE": "Cancer immunotherapy by PD-1 blockade", "WP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING": "Canonical and non-canonical Notch signaling", "WP_CANNABINOID_RECEPTOR_SIGNALING": "Cannabinoid receptor signaling", "WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING": "Canonical and non-canonical TGF-B signaling", "WP_CANONICAL_NFKB_PATHWAY": "Canonical NF-kB pathway", "WP_CARDIAC_HYPERTROPHIC_RESPONSE": "Cardiac hypertrophic response", "WP_CANCER_PATHWAYS": "Cancer pathways", "WP_CARDIAC_PROGENITOR_DIFFERENTIATION": "Cardiac progenitor differentiation", "WP_CATALYTIC_CYCLE_OF_MAMMALIAN_FLAVINCONTAINING_MONOOXYGENASES_FMOS": "Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)", "WP_CARDIOMYOCYTE_SIGNALING_CONVERGING_ON_TITIN": "Cardiomyocyte signaling converging on titin", "WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA": "Catabolism of skeletal muscle in cachexia", "WP_CELLS_AND_MOLECULES_INVOLVED_IN_LOCAL_ACUTE_INFLAMMATORY_RESPONSE": "Cells and molecules involved in local acute inflammatory response", "WP_CCL18_SIGNALING": "CCL18 signaling", "WP_CELLULAR_PROTEOSTASIS": "Cellular proteostasis", "WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING": "Cell-type dependent selectivity of CCK2R signaling", "WP_CELL_CYCLE": "Cell cycle", "WP_CELL_DIFFERENTIATION_INDEX": "Cell differentiation - index", "WP_CELL_DIFFERENTIATION_EXPANDED_INDEX": "Cell differentiation - expanded index", "WP_CEREBRAL_ORGANIC_ACIDURIAS_INCLUDING_DISEASES": "Cerebral organic acidurias, including diseases", "WP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION": "Cell lineage map for neuronal differentiation", "WP_CELL_INTERACTIONS_OF_THE_PANCREATIC_CANCER_MICROENVIRONMENT": "", "WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES": "Cholesterol biosynthesis pathway in hepatocytes", "WP_CHEMOKINE_SIGNALING": "Chemokine signaling", "WP_CHOLESTEROL_BIOSYNTHESIS_WITH_SKELETAL_DYSPLASIAS": "Cholesterol biosynthesis with skeletal dysplasias", "WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY": "Cholesterol biosynthesis pathway", "WP_CHOLESTASIS": "Cholestasis", "WP_CHOLESTEROL_METABOLISM": "Cholesterol metabolism", "WP_CHOLESTEROL_SYNTHESIS_DISORDERS": "Cholesterol synthesis disorders", "WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS": "Cholesterol metabolism with Bloch and Kandutsch-Russell pathways", "WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER": "Chromosomal and microsatellite instability in colorectal cancer", "WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM": "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION": "Chronic hyperglycemia impairment of neuron function", "WP_CIRCADIAN_RHYTHM_GENES": "Circadian rhythm genes", "WP_CODEINE_AND_MORPHINE_METABOLISM": "Codeine and morphine metabolism", "WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS": "Clear cell renal cell carcinoma pathways", "WP_CILIOPATHIES": "Ciliopathies", "WP_CILIARY_LANDSCAPE": "Ciliary landscape", "WP_CLOCKCONTROLLED_AUTOPHAGY_IN_BONE_METABOLISM": "Clock-controlled autophagy in bone metabolism", "WP_COHESIN_COMPLEX_CORNELIA_DE_LANGE_SYNDROME": "Cohesin complex - Cornelia de Lange syndrome", "WP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION": "Common pathways underlying drug addiction", "WP_COMPLEMENTMEDIATED_INFLAMMATION_OF_PULMONARY_ALVEOLUS_IN_COVID19_HYPOTHETICAL_PATHWAY": "Complement-mediated inflammation of pulmonary alveolus in COVID-19 (hypothetical pathway)", "WP_COMPLEMENT_ACTIVATION": "Complement activation", "WP_COMPLEMENT_AND_COAGULATION_CASCADES": "Complement and coagulation cascades", "WP_COMPLEMENT_SYSTEM": "Complement system", "WP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY": "Complement system in neuronal development and plasticity", "WP_CONGENITAL_GENERALIZED_LIPODYSTROPHY": "Congenital generalized lipodystrophy", "WP_CONTROL_OF_IMMUNE_TOLERANCE_BY_VASOACTIVE_INTESTINAL_PEPTIDE": "Control of immune tolerance by vasoactive intestinal peptide", "WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY": "Constitutive androstane receptor pathway", "WP_CONVERSION_OF_ANGIOTENSINOGEN_TO_ANGIOTENSIN_II": "Conversion of angiotensinogen to angiotensin II", "WP_CORI_CYCLE": "Cori cycle", "WP_CORTICOTROPINRELEASING_HORMONE_SIGNALING": "Corticotropin-releasing hormone signaling", "WP_COPPER_HOMEOSTASIS": "Copper homeostasis", "WP_COVID19_AND_ENDOTHELIAL_CELL_SENESCENCE": "COVID-19 and endothelial cell senescence", "WP_COVID19_ADVERSE_OUTCOME_PATHWAY": "COVID-19 adverse outcome pathway", "WP_COVID19_THROMBOSIS_AND_ANTICOAGULATION": "COVID-19, thrombosis and anticoagulation", "WP_CREATINE_PATHWAY": "Creatine pathway", "WP_CYSTEINE_AND_METHIONINE_CATABOLISM": "Cysteine and methionine catabolism", "WP_COVID19_STRUCTURAL_COVERAGE_MAP": "COVID-19 structural coverage map", "WP_CYTOKINES_AND_INFLAMMATORY_RESPONSE": "Cytokines and inflammatory response", "WP_CYTOSINE_METHYLATION": "Cytosine methylation", "WP_CYTOPLASMIC_RIBOSOMAL_PROTEINS": "Cytoplasmic ribosomal proteins", "WP_DDX1_AS_A_REGULATORY_COMPONENT_OF_THE_DROSHA_MICROPROCESSOR": "DDX1 as a regulatory component of the Drosha microprocessor", "WP_CYTOSOLIC_DNASENSING_PATHWAY": "Cytosolic DNA-sensing pathway", "WP_CYTOKINECYTOKINE_RECEPTOR_INTERACTION": "Cytokine-cytokine receptor interaction", "WP_DEGRADATION_PATHWAY_OF_SPHINGOLIPIDS_INCLUDING_DISEASES": "Degradation pathway of sphingolipids, including diseases", "WP_DEVELOPMENT_AND_HETEROGENEITY_OF_THE_ILC_FAMILY": "Development and heterogeneity of the ILC family", "WP_DEREGULATION_OF_RAB_AND_RAB_EFFECTOR_GENES_IN_BLADDER_CANCER": "Deregulation of Rab and Rab effector genes in bladder cancer", "WP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES": "Dengue-2 interactions with complement and coagulation cascades", "WP_DEVELOPMENT_OF_PULMONARY_DENDRITIC_CELLS_AND_MACROPHAGE_SUBSETS": "Development of pulmonary dendritic cells and macrophage subsets", "WP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM": "", "WP_DIFFERENTIATION_OF_WHITE_AND_BROWN_ADIPOCYTE": "Differentiation of white and brown adipocyte", "WP_DISORDERS_IN_KETOLYSIS": "Disorders in ketolysis", "WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT": "Disorders of bile acid synthesis and biliary transport", "WP_DISORDERS_OF_FOLATE_METABOLISM_AND_TRANSPORT": "Disorders of folate metabolism and transport", "WP_DISORDERS_OF_FRUCTOSE_METABOLISM": "Disorders of fructose metabolism", "WP_DISORDERS_IN_KETONE_BODY_SYNTHESIS": "Disorders in ketone body synthesis", "WP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV": "Disruption of postsynaptic signaling by CNV", "WP_DISORDERS_OF_GALACTOSE_METABOLISM": "Disorders of galactose metabolism", "WP_DNA_DAMAGE_RESPONSE": "DNA damage response", "WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT": "DNA damage response (only ATM dependent)", "WP_DNA_MISMATCH_REPAIR": "DNA mismatch repair", "WP_DNA_IRDAMAGE_AND_CELLULAR_RESPONSE_VIA_ATR": "DNA IR-damage and cellular response via ATR", "WP_DNA_IRDOUBLE_STRAND_BREAKS_AND_CELLULAR_RESPONSE_VIA_ATM": "DNA IR-double strand breaks and cellular response via ATM", "WP_DNA_REPAIR_PATHWAYS_FULL_NETWORK": "DNA repair pathways, full network", "WP_DOPAMINERGIC_NEUROGENESIS": "Dopaminergic neurogenesis", "WP_DRAVET_SYNDROME": "Dravet syndrome", "WP_DOPAMINE_METABOLISM": "Dopamine metabolism", "WP_DNA_REPLICATION": "DNA replication", "WP_DUAL_HIJACK_MODEL_OF_VIF_IN_HIV_INFECTION": "Dual hijack model of Vif in HIV infection", "WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY": "Drug induction of bile acid pathway", "WP_EBSTEINBARR_VIRUS_LMP1_SIGNALING": "Ebstein-Barr virus LMP1 signaling", "WP_EBOLA_VIRUS_INFECTION_IN_HOST": "Ebola virus infection in host", "WP_DYRK1A_INVOLVEMENT_REGARDING_CELL_PROLIFERATION_IN_BRAIN_DEVELOPMENT": "DYRK1A involvement regarding cell proliferation in brain development", "WP_EDA_SIGNALING_IN_HAIR_FOLLICLE_DEVELOPMENT": "EDA signaling in hair follicle development", "WP_EFFECTS_OF_MFN2_MUTATION": "Effects of MFN2 mutation", "WP_EFFECTS_OF_NITRIC_OXIDE": "Effects of nitric oxide", "WP_EFFECT_OF_INTESTINAL_MICROBIOME_ON_ANTICOAGULANT_RESPONSE_OF_VITAMIN_K_ANTAGONISTS": "Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists", "WP_ECTODERM_DIFFERENTIATION": "Ectoderm differentiation", "WP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA": "Effect of progerin on genes involved in progeria", "WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS": "Effect of omega-3 PUFA on Huntington's disease pathways", "WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE": "EGFR tyrosine kinase inhibitor resistance", "WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY": "Eicosanoid metabolism via cytochrome P450 monooxygenases pathway", "WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX": "Eicosanoid metabolism via cyclooxygenases (COX)", "WP_EGFEGFR_SIGNALING": "EGF/EGFR signaling", "WP_EICOSANOID_METABOLISM_VIA_LIPOOXYGENASES_LOX": "Eicosanoid metabolism via lipooxygenases (LOX)", "WP_EICOSANOID_SYNTHESIS": "Eicosanoid synthesis", "WP_ELECTRON_TRANSPORT_CHAIN_OXPHOS_SYSTEM_IN_MITOCHONDRIA": "Electron transport chain: OXPHOS system in mitochondria", "WP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS": "Embryonic stem cell pluripotency pathways", "WP_ENDOCHONDRAL_OSSIFICATION": "Endochondral ossification", "WP_ENDOCHONDRAL_OSSIFICATION_WITH_SKELETAL_DYSPLASIAS": "Endochondral ossification with skeletal dysplasias", "WP_ENDOMETRIAL_CANCER": "Endometrial cancer", "WP_ENDODERM_DIFFERENTIATION": "Endoderm differentiation", "WP_ENDOPLASMIC_RETICULUM_STRESS_RESPONSE_IN_CORONAVIRUS_INFECTION": "Endoplasmic reticulum stress response in coronavirus infection", "WP_ENDOTHELIN_PATHWAYS": "Endothelin pathways", "WP_ENTEROCYTE_CHOLESTEROL_METABOLISM": "Enterocyte cholesterol metabolism", "WP_ENERGY_METABOLISM": "Energy metabolism", "WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS": "Enterohepatic circulation of bile acids", "WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY": "Envelope proteins and their potential roles in EDMD physiopathology", "WP_EPAC1_AND_PKA_REDUCTION_OF_RETINAL_INFLAMMATION": "EPAC1 and PKA reduction of retinal inflammation", "WP_EPO_RECEPTOR_SIGNALING": "EPO receptor signaling", "WP_ERK_PATHWAY_IN_HUNTINGTONS_DISEASE": "ERK pathway in Huntington's disease", "WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER": "Epithelial to mesenchymal transition in colorectal cancer", "WP_ESTRADIOL_REGULATION_IN_PORTOSINUSOIDAL_VASCULAR_DISEASE": "Estradiol regulation in porto-sinusoidal vascular disease", "WP_ERBB_SIGNALING": "ErbB signaling", "WP_ESTROGEN_METABOLISM_WP697": "Estrogen metabolism", "WP_ESTROGEN_RECEPTOR_PATHWAY": "Estrogen receptor pathway", "WP_ESTROGEN_METABOLISM_WP5276": "Estrogen metabolism", "WP_ESTROGEN_SIGNALING": "Estrogen signaling", "WP_ETHANOL_EFFECTS_ON_HISTONE_MODIFICATIONS": "Ethanol effects on histone modifications", "WP_ETHANOL_METABOLISM_PRODUCTION_OF_ROS_BY_CYP2E1": "Ethanol metabolism production of ROS by CYP2E1", "WP_ETHER_LIPID_BIOSYNTHESIS": "Ether lipid biosynthesis", "WP_EV_RELEASE_FROM_CARDIAC_CELLS_AND_THEIR_FUNCTIONAL_EFFECTS": "EV release from cardiac cells and their functional effects", "WP_EXERCISEINDUCED_CIRCADIAN_REGULATION": "Exercise-induced circadian regulation", "WP_EUKARYOTIC_TRANSCRIPTION_INITIATION": "Eukaryotic transcription initiation", "WP_EXRNA_MECHANISM_OF_ACTION_AND_BIOGENESIS": "exRNA mechanism of action and biogenesis", "WP_EXTRACELLULAR_VESICLES_IN_THE_CROSSTALK_OF_CARDIAC_CELLS": "Extracellular vesicles in the crosstalk of cardiac cells", "WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS": "Extracellular vesicle-mediated signaling in recipient cells", "WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_1": "Familial  hyperlipidemia type 1", "WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING": "Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling", "WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_2": "Familial hyperlipidemia type 2", "WP_EXTRAFOLLICULAR_AND_FOLLICULAR_B_CELL_ACTIVATION_BY_SARSCOV2": "Extrafollicular and follicular B cell activation by SARS-CoV-2", "WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_3": "Familial hyperlipidemia type 3", "WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_5": "Familial hyperlipidemia type 5", "WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_4": "Familial hyperlipidemia type 4", "WP_FAMILIAL_PARTIAL_LIPODYSTROPHY": "Familial partial lipodystrophy", "WP_FARNESOID_X_RECEPTOR_PATHWAY": "Farnesoid X receptor pathway", "WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES": "", "WP_FATTY_ACID_BETAOXIDATION": "Fatty acid beta-oxidation", "WP_FAS_LIGAND_PATHWAY_AND_STRESS_INDUCTION_OF_HEAT_SHOCK_PROTEINS": "Fas ligand pathway and stress induction of heat shock proteins", "WP_FATTY_ACID_OMEGAOXIDATION": "Fatty acid omega-oxidation", "WP_FATTY_ACID_BIOSYNTHESIS": "Fatty acid biosynthesis", "WP_FATTY_ACID_TRANSPORTERS": "Fatty acid transporters", "WP_FEMALE_STEROID_HORMONES_IN_CARDIOMYOCYTE_ENERGY_METABOLISM": "Female steroid hormones in cardiomyocyte energy metabolism", "WP_FGF23_SIGNALING_IN_HYPOPHOSPHATEMIC_RICKETS_AND_RELATED_DISORDERS": "FGF23 signaling in hypophosphatemic rickets and related disorders", "WP_FBXL10_ENHANCEMENT_OF_MAPERK_SIGNALING_IN_DIFFUSE_LARGE_BCELL_LYMPHOMA": "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma", "WP_FERROPTOSIS": "Ferroptosis", "WP_FGFR3_SIGNALING_IN_CHONDROCYTE_PROLIFERATION_AND_TERMINAL_DIFFERENTIATION": "FGFR3 signaling in chondrocyte proliferation and terminal differentiation", "WP_FLUOROACETIC_ACID_TOXICITY": "Fluoroacetic acid toxicity", "WP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING": "Fibrin complement receptor 3 signaling", "WP_FLUOROPYRIMIDINE_ACTIVITY": "Fluoropyrimidine activity", "WP_FOCAL_ADHESION": "Focal adhesion", "WP_FOLATEALCOHOL_AND_CANCER_PATHWAY_HYPOTHESES": "Folate-alcohol and cancer pathway hypotheses", "WP_FOXA2_PATHWAY": "FOXA2 pathway", "WP_FOLLICLE_STIMULATING_HORMONE_FSH_SIGNALING": "Follicle stimulating hormone (FSH) signaling", "WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING": "Focal adhesion: PI3K-Akt-mTOR-signaling", "WP_FOLATE_METABOLISM": "Folate metabolism", "WP_FOXP3_IN_COVID19": "FOXP3 in COVID-19", "WP_FRAGILE_X_SYNDROME": "Fragile X syndrome", "WP_FTO_OBESITY_VARIANT_MECHANISM": "FTO obesity variant mechanism", "WP_G13_SIGNALING": "G13 signaling", "WP_GABA_METABOLISM_AKA_GHB": "GABA metabolism (aka GHB)", "WP_GABA_RECEPTOR_SIGNALING": "GABA receptor signaling", "WP_GALANIN_RECEPTOR_PATHWAY": "Galanin receptor pathway", "WP_G1_TO_S_CELL_CYCLE_CONTROL": "G1 to S cell cycle control", "WP_GANGLIO_SERIES_SPHINGOLIPID_METABOLISM": "Ganglio series sphingolipid metabolism", "WP_GAMMAGLUTAMYL_CYCLE_FOR_THE_BIOSYNTHESIS_AND_DEGRADATION_OF_GLUTATHIONE_INCLUDING_DISEASES": "", "WP_GANGLIO_SPHINGOLIPID_METABOLISM": "Ganglio sphingolipid metabolism", "WP_GASTRIC_ACID_PRODUCTION": "Gastric acid production", "WP_GASTRIC_CANCER_NETWORK_1": "Gastric cancer network 1", "WP_GASTRIC_CANCER_NETWORK_2": "Gastric cancer network 2", "WP_GASTRIN_SIGNALING": "Gastrin signaling", "WP_GENES_ASSOCIATED_WITH_THE_DEVELOPMENT_OF_RHEUMATOID_ARTHRITIS": "Genes associated with the development of rheumatoid arthritis", "WP_GDNFRET_SIGNALING_AXIS": "GDNF/RET signaling axis", "WP_GENES_TARGETED_BY_MIRNAS_IN_ADIPOCYTES": "Genes targeted by miRNAs in adipocytes", "WP_GENES_RELATED_TO_PRIMARY_CILIUM_DEVELOPMENT_BASED_ON_CRISPR": "Genes related to primary cilium development (based on CRISPR)", "WP_GENES_CONTROLLING_NEPHROGENESIS": "Genes controlling nephrogenesis", "WP_GENE_REGULATORY_NETWORK_MODELING_SOMITOGENESIS": "Gene regulatory network modeling somitogenesis", "WP_GENETIC_CAUSES_OF_PORTOSINUSOIDAL_VASCULAR_DISEASE": "Genetic causes of porto-sinusoidal vascular disease", "WP_GLIAL_CELL_DIFFERENTIATION": "Glial cell differentiation", "WP_GLIOBLASTOMA_SIGNALING": "Glioblastoma signaling", "WP_GLP1_FROM_INTESTINE_AND_PANCREAS_AND_ROLE_IN_GLUCOSE_HOMEOSTASIS": "GLP-1 from intestine and pancreas and role in glucose homeostasis", "WP_GLP1_IN_PANCREATIC_ISLET_CELLS": "GLP-1 in pancreatic islet cells", "WP_GLP1_SECRETION_FROM_INTESTINE_TO_PORTAL_VEIN": "GLP-1 secretion from intestine to portal vein", "WP_GLUCOCORTICOID_BIOSYNTHESIS": "Glucocorticoid biosynthesis", "WP_GLUCOSE_METABOLISM_IN_TRIPLENEGATIVE_BREAST_CANCER_CELLS": "Glucose metabolism in triple-negative breast cancer cells", "WP_GLUCURONIDATION": "Glucuronidation", "WP_GLUTATHIONE_METABOLISM": "Glutathione metabolism", "WP_GLUCOCORTICOID_RECEPTOR_PATHWAY": "Glucocorticoid receptor pathway", "WP_GLYCEROLIPIDS_AND_GLYCEROPHOSPHOLIPIDS": "Glycerolipids and glycerophospholipids", "WP_GLYCINE_METABOLISM_INCLUDING_IMDS": "Glycine metabolism, including IMDs", "WP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PATHWAY": "Glycerophospholipid biosynthetic pathway", "WP_GLYCOLYSIS_IN_SENESCENCE": "Glycolysis in senescence", "WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION": "Glycogen synthesis and degradation", "WP_GLYCOLYSIS_AND_GLUCONEOGENESIS": "Glycolysis and gluconeogenesis", "WP_GLYCOSAMINOGLYCAN_DEGRADATION": "Glycosaminoglycan degradation", "WP_GLYCOSPHINGOLIPID_METABOLISM": "Glycosphingolipid metabolism", "WP_GLYCOSYLATION_AND_RELATED_CONGENITAL_DEFECTS": "Glycosylation and related congenital defects", "WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS": "Glycosaminoglycan synthesis in fibroblasts", "WP_GNAQ_PATHWAYS_IN_PORTWINE_STAIN": "GNAQ pathways in port-wine stain", "WP_GLYOXYLATE_METABOLISM": "Glyoxylate metabolism", "WP_GPCRS_CLASS_B_SECRETINLIKE": "GPCRs, class B secretin-like", "WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE": "GPCRs, class C metabotropic glutamate, pheromone", "WP_GPCRS_CLASS_A_RHODOPSINLIKE": "GPCRs, class A rhodopsin-like", "WP_GPR40_PATHWAY": "", "WP_GPCRS_OTHER": "GPCRs, other", "WP_GROWTH_FACTORS_AND_HORMONES_IN_BETA_CELL_PROLIFERATION": "Growth factors and hormones in beta cell proliferation", "WP_GPR143_IN_MELANOCYTES_AND_RETINAL_PIGMENT_EPITHELIUM_CELLS": "GPR143 in melanocytes and retinal pigment epithelium cells", "WP_G_PROTEIN_SIGNALING": "G protein signaling", "WP_H19_RBE2F1_AND_CDKBETACATENIN_IN_COLORECTAL_CANCER": "H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer", "WP_HAIR_FOLLICLE_DEVELOPMENT_CYTODIFFERENTIATION_STAGE_3_OF_3": "Hair follicle development: cytodifferentiation - stage 3 of 3", "WP_HAIR_FOLLICLE_DEVELOPMENT_ORGANOGENESIS_STAGE_2_OF_3": "Hair follicle development: organogenesis - stage 2 of 3", "WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM": "HDAC6 interactions in the central nervous system", "WP_HEDGEHOG_SIGNALING_WP47": "Hedgehog signaling", "WP_HEAD_AND_NECK_SQUAMOUS_CELL_CARCINOMA": "Head and neck squamous cell carcinoma", "WP_HEART_DEVELOPMENT": "Heart development", "WP_HEDGEHOG_SIGNALING_WP4249": "Hedgehog signaling", "WP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX": "Hematopoietic stem cell gene regulation by GABP alpha/beta complex", "WP_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION": "Hematopoietic stem cell differentiation", "WP_HEMESYNTHESIS_DEFECTS_AND_PORPHYRIAS": "Hemesynthesis defects and porphyrias", "WP_HEME_BIOSYNTHESIS": "Heme biosynthesis", "WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA": "Hepatitis C and hepatocellular carcinoma", "WP_HEREDITARY_LEIOMYOMATOSIS_AND_RENAL_CELL_CARCINOMA_PATHWAY": "Hereditary leiomyomatosis and renal cell carcinoma pathway", "WP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING": "Hepatocyte growth factor receptor signaling", "WP_HFE_EFFECT_ON_HEPCIDIN_PRODUCTION": "Hfe effect on hepcidin production", "WP_HIF1A_AND_PPARG_REGULATION_OF_GLYCOLYSIS": "", "WP_HEPATITIS_B_INFECTION": "Hepatitis B infection", "WP_HIPPOYAP_SIGNALING": "Hippo-YAP signaling", "WP_HIJACK_OF_UBIQUITINATION_BY_SARSCOV2": "Hijack of ubiquitination by SARS-CoV-2", "WP_HIPPOCAMPAL_SYNAPTOGENESIS_AND_NEUROGENESIS": "Hippocampal synaptogenesis and neurogenesis", "WP_HIPPOMERLIN_SIGNALING_DYSREGULATION": "Hippo-Merlin signaling dysregulation", "WP_HOMOLOGOUS_RECOMBINATION": "Homologous recombination", "WP_HIPPO_SIGNALING_REGULATION": "Hippo signaling regulation", "WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_APOPTOSIS": "Host-pathogen interaction of human coronaviruses - apoptosis", "WP_HORMONAL_CONTROL_OF_PUBERTAL_GROWTH_SPURT": "Hormonal control of pubertal growth spurt", "WP_HISTONE_MODIFICATIONS": "Histone modifications", "WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_AUTOPHAGY": "Host-pathogen interaction of human coronaviruses - autophagy", "WP_HUNGER_AND_SATIETY": "Hunger and satiety", "WP_HYPERTROPHY_MODEL": "", "WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING": "Host-pathogen interaction of human coronaviruses - MAPK signaling", "WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_INTERFERON_INDUCTION": "Host-pathogen interaction of human coronaviruses - interferon induction", "WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE": "Hypothesized pathways in pathogenesis of cardiovascular disease", "WP_HYPOTHETICAL_CRANIOFACIAL_DEVELOPMENT_PATHWAY": "Hypothetical craniofacial development pathway", "WP_IDO_METABOLIC_PATHWAY": "IDO metabolic pathway", "WP_ID_SIGNALING": "ID signaling", "WP_IL10_ANTIINFLAMMATORY_SIGNALING": "IL10 anti-inflammatory signaling", "WP_IL11_SIGNALING": "IL11 signaling", "WP_IL17_SIGNALING": "IL17 signaling", "WP_IL1_AND_MEGAKARYOCYTES_IN_OBESITY": "IL1 and megakaryocytes in obesity", "WP_IL19_SIGNALING": "IL19 signaling", "WP_IL26_SIGNALING": "IL26 signaling", "WP_IL18_SIGNALING": "IL18 signaling", "WP_IL1_SIGNALING": "IL1 signaling", "WP_IL3_SIGNALING": "IL3 signaling", "WP_IL2_SIGNALING": "IL2 signaling", "WP_IL4_SIGNALING": "IL4 signaling", "WP_IL5_SIGNALING": "IL5 signaling", "WP_IL9_SIGNALING": "IL9 signaling", "WP_IL6_SIGNALING": "IL6 signaling", "WP_IL7_SIGNALING": "IL7 signaling", "WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA": "Imatinib and chronic myeloid leukemia", "WP_IMMUNE_RESPONSE_TO_TUBERCULOSIS": "", "WP_IMMUNE_INFILTRATION_IN_PANCREATIC_CANCER": "Immune infiltration in pancreatic cancer", "WP_INDUCTION_OF_AUTOPHAGY_AND_TOLLLIKE_RECEPTOR_SIGNALING_BY_GRAPHENE_OXIDE": "Induction of autophagy and toll-like receptor signaling by graphene oxide", "WP_INCLUSION_BODY_MYOSITIS": "Inclusion body myositis", "WP_INFLAMMATORY_RESPONSE_PATHWAY": "Inflammatory response pathway", "WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING": "Inflammatory bowel disease signaling", "WP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS": "Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells", "WP_INFLUENCE_OF_LAMINOPATHIES_ON_WNT_SIGNALING": "Influence of laminopathies on Wnt signaling", "WP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR": "Initiation of transcription and translation elongation at the HIV-1 LTR", "WP_INSULIN_SIGNALING_IN_ADIPOCYTES_DIABETIC_CONDITION": "Insulin signaling in adipocytes (diabetic condition)", "WP_INSULIN_SIGNALING_IN_ADIPOCYTES_NORMAL_CONDITION": "Insulin signaling in adipocytes (normal condition)", "WP_INSULIN_SIGNALING": "Insulin signaling", "WP_INTEGRINMEDIATED_CELL_ADHESION": "Integrin-mediated cell adhesion", "WP_INTERACTIONS_BETWEEN_LOXL4_AND_OXIDATIVE_STRESS_PATHWAY": "Interactions between LOXL4 and oxidative stress pathway", "WP_INTERACTIONS_OF_NATURAL_KILLER_CELLS_IN_PANCREATIC_CANCER": "Interactions of natural killer cells in pancreatic cancer", "WP_INTEGRATED_CANCER_PATHWAY": "Integrated cancer pathway", "WP_INTERACTIONS_BETWEEN_IMMUNE_CELLS_AND_MICRORNAS_IN_TUMOR_MICROENVIRONMENT": "Interactions between immune cells and microRNAs in tumor microenvironment", "WP_INTERACTOME_OF_POLYCOMB_REPRESSIVE_COMPLEX_2_PRC2": "Interactome of polycomb repressive complex 2 (PRC2)", "WP_INTERFERONMEDIATED_SIGNALING": "Interferon-mediated signaling", "WP_INTERFERON_TYPE_I_SIGNALING": "Interferon type I signaling", "WP_INTERLEUKIN1_INDUCED_ACTIVATION_OF_NFKB": "Interleukin-1 induced activation of NF-kB", "WP_INTRAFLAGELLAR_TRANSPORT_PROTEINS_BINDING_TO_DYNEIN": "Intraflagellar transport proteins binding to dynein", "WP_INTRACELLULAR_TRAFFICKING_PROTEINS_INVOLVED_IN_CMT_NEUROPATHY": "Intracellular trafficking proteins involved in CMT neuropathy", "WP_INTERLEUKIN1_IL1_STRUCTURAL_PATHWAY": "Interleukin-1 (IL-1) structural pathway", "WP_IRINOTECAN_PATHWAY": "Irinotecan pathway", "WP_IRONSULFUR_CLUSTER_BIOGENESIS": "Iron-sulfur cluster biogenesis", "WP_INVOLVEMENT_OF_SECRETASE_IN_NEURODEGENERATIVE_DISEASES": "Involvement of ?-secretase in neurodegenerative diseases", "WP_IRON_METABOLISM_IN_PLACENTA": "Iron metabolism in placenta", "WP_IRON_METABOLISM_DISORDERS": "Iron metabolism disorders", "WP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS": "JAK-STAT signaling in the regulation of beta cells", "WP_JOUBERT_SYNDROME": "Joubert syndrome", "WP_KALLMANN_SYNDROME": "Kallmann syndrome", "WP_KENNEDY_PATHWAY_FROM_SPHINGOLIPIDS": "Kennedy pathway from sphingolipids", "WP_KCNQ2RELATED_EPILEPSIES": "KCNQ2-related epilepsies", "WP_KININKALLIKREIN_PATHWAY": "Kinin-Kallikrein pathway", "WP_KETOGENESIS_AND_KETOLYSIS": "Ketogenesis and ketolysis", "WP_KREBS_CYCLE_DISORDERS": "Krebs cycle disorders", "WP_KLEEFSTRA_SYNDROME": "Kleefstra syndrome", "WP_KISSPEPTINKISSPEPTIN_RECEPTOR_SYSTEM_IN_THE_OVARY": "Kisspeptin/kisspeptin receptor system in the ovary", "WP_KIT_RECEPTOR_SIGNALING": "Kit receptor signaling", "WP_KYNURENINE_PATHWAY_AND_LINKS_TO_CELL_SENESCENCE": "Kynurenine pathway and links to cell senescence", "WP_LACTATE_SHUTTLE_IN_GLIAL_CELLS": "Lactate shuttle in glial cells", "WP_LACTO_SERIES_SPHINGOLIPID_METABOLISM": "Lacto series sphingolipid metabolism", "WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT": "", "WP_LEPTININSULIN_SIGNALING_OVERLAP": "Leptin-insulin signaling overlap", "WP_LDL_INFLUENCE_ON_CD14_AND_TLR4": "LDL- influence on CD14 and TLR4", "WP_LEPTIN_AND_ADIPONECTIN": "Leptin and adiponectin", "WP_LEPTIN_SIGNALING": "Leptin signaling", "WP_LET7_INHIBITION_OF_ES_CELL_REPROGRAMMING": "let-7 inhibition of ES cell reprogramming", "WP_LEUCINE_ISOLEUCINE_AND_VALINE_METABOLISM": "Leucine, isoleucine and valine metabolism", "WP_LEUKOTRIENE_METABOLIC_PATHWAY": "Leukotriene metabolic pathway", "WP_LEUKOCYTEINTRINSIC_HIPPO_PATHWAY_FUNCTIONS": "Leukocyte-intrinsic Hippo pathway functions", "WP_LIPID_METABOLISM_IN_SENESCENT_CELLS": "Lipid metabolism in senescent cells", "WP_LINOLEIC_ACID_METABOLISM_AFFECTED_BY_SARSCOV2": "Linoleic acid metabolism affected by SARS-CoV-2", "WP_LIPID_METABOLISM_PATHWAY": "Lipid metabolism pathway", "WP_LIPID_PARTICLES_COMPOSITION": "Lipid particles composition", "WP_LIVER_X_RECEPTOR_PATHWAY": "Liver X receptor pathway", "WP_LTF_DANGER_SIGNAL_RESPONSE_PATHWAY": "LTF danger signal response pathway", "WP_LNCRNAMEDIATED_MECHANISMS_OF_THERAPEUTIC_RESISTANCE": "lncRNA-mediated mechanisms of therapeutic resistance", "WP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER": "lncRNA in canonical Wnt signaling and colorectal cancer", "WP_LUNG_PATHOLOGY_OF_COVID19": "Lung pathology of COVID-19", "WP_LUNG_FIBROSIS": "Lung fibrosis", "WP_MACROPHAGE_MARKERS": "Macrophage markers", "WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE": "Major receptors targeted by epinephrine and norepinephrine", "WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING": "Macrophage-stimulating protein (MSP) signaling", "WP_MALE_STEROID_HORMONES_IN_CARDIOMYOCYTE_ENERGY_METABOLISM": "Male steroid hormones in cardiomyocyte energy metabolism", "WP_MALE_INFERTILITY": "Male infertility", "WP_MAMMALIAN_DISORDER_OF_SEXUAL_DEVELOPMENT": "Mammalian disorder of sexual development", "WP_MAMMARY_GLAND_DEVELOPMENT_EMBRYONIC_DEVELOPMENT_STAGE_1_OF_4": "Mammary gland development: embryonic development - stage 1 of 4", "WP_MAMMARY_GLAND_DEVELOPMENT_INVOLUTION_STAGE_4_OF_4": "Mammary gland development: involution - stage 4 of 4", "WP_MAP3K1_ROLE_IN_PROMOTING_AND_BLOCKING_GONADAL_DETERMINATION": "MAP3K1 role in promoting and blocking gonadal determination", "WP_MAMMARY_GLAND_DEVELOPMENT_PUBERTY_STAGE_2_OF_4": "Mammary gland development: puberty - stage 2 of 4", "WP_MAMMARY_GLAND_DEVELOPMENT_PREGNANCY_AND_LACTATION_STAGE_3_OF_4": "Mammary gland development: pregnancy and lactation - stage 3 of 4", "WP_MAPK_AND_NFKB_SIGNALING_INHIBITED_BY_YERSINIA_YOPJ": "MAPK and NFkB signaling inhibited by Yersinia YopJ", "WP_MAPK_CASCADE": "MAPK cascade", "WP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER": "MAPK pathway in congenital thyroid cancer", "WP_MARKERS_OF_KIDNEY_CELL_LINEAGE": "Markers of kidney cell lineage", "WP_MATRIX_METALLOPROTEINASES": "Matrix metalloproteinases", "WP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION": "mBDNF and proBDNF regulation of GABA neurotransmission", "WP_MAPK_SIGNALING": "MAPK signaling", "WP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS": "Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms", "WP_MEASLES_VIRUS_INFECTION": "Measles virus infection", "WP_MECP2_AND_ASSOCIATED_RETT_SYNDROME": "MECP2 and associated Rett syndrome", "WP_MELANOMA": "Melanoma", "WP_MELATONIN_METABOLISM_AND_EFFECTS": "Melatonin metabolism and effects", "WP_MESODERMAL_COMMITMENT_PATHWAY": "Mesodermal commitment pathway", "WP_METABOLIC_EPILEPTIC_DISORDERS": "Metabolic epileptic disorders", "WP_METABOLIC_PATHWAY_OF_LDL_HDL_AND_TG_INCLUDING_DISEASES": "Metabolic pathway of LDL, HDL and TG, including diseases", "WP_METABOLIC_PATHWAYS_OF_FIBROBLASTS": "Metabolic pathways of fibroblasts", "WP_METABOLIC_REPROGRAMMING_IN_COLON_CANCER": "Metabolic reprogramming in colon cancer", "WP_METABOLISM_OF_ALPHALINOLENIC_ACID": "Metabolism of alpha-linolenic acid", "WP_METABOLISM_OF_SPHINGOLIPIDS_IN_ER_AND_GOLGI_APPARATUS": "Metabolism of sphingolipids in ER and Golgi apparatus", "WP_METASTATIC_BRAIN_TUMOR": "Metastatic brain tumor", "WP_METABOLIC_REPROGRAMMING_IN_PANCREATIC_CANCER": "Metabolic reprogramming in pancreatic cancer", "WP_METHIONINE_DE_NOVO_AND_SALVAGE_PATHWAY": "Methionine de novo and salvage pathway", "WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II": "Metapathway biotransformation Phase I and II", "WP_METHIONINE_METABOLISM_LEADING_TO_SULFUR_AMINO_ACIDS_AND_RELATED_DISORDERS": "Methionine metabolism leading to sulfur amino acids and related disorders", "WP_METHYLATION_PATHWAYS": "Methylation pathways", "WP_MEVALONATE_ARM_OF_CHOLESTEROL_BIOSYNTHESIS_PATHWAY": "Mevalonate arm of cholesterol biosynthesis pathway", "WP_MFAP5MEDIATED_OVARIAN_CANCER_CELL_MOTILITY_AND_INVASIVENESS": "MFAP5-mediated ovarian cancer cell motility and invasiveness", "WP_MEVALONATE_PATHWAY": "Mevalonate pathway", "WP_MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA": "MET in type 1 papillary renal cell carcinoma", "WP_MFAP5_EFFECT_ON_PERMEABILITY_AND_MOTILITY_OF_ENDOTHELIAL_CELLS_VIA_CYTOSKELETON_REARRANGEMENT": "MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "WP_MICRORNA_FOR_TARGETING_CANCER_GROWTH_AND_VASCULARIZATION_IN_GLIOBLASTOMA": "MicroRNA for targeting cancer growth and vascularization in glioblastoma", "WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY": "MicroRNAs in cardiomyocyte hypertrophy", "WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY": "Microglia pathogen phagocytosis pathway", "WP_MICRORNA_NETWORK_ASSOCIATED_WITH_CHRONIC_LYMPHOCYTIC_LEUKEMIA": "MicroRNA network associated with chronic lymphocytic leukemia", "WP_MINERALOCORTICOID_BIOSYNTHESIS": "Mineralocorticoid biosynthesis", "WP_MICROTUBULE_CYTOSKELETON_REGULATION": "Microtubule cytoskeleton regulation", "WP_MIR124_PREDICTED_INTERACTIONS_WITH_CELL_CYCLE_AND_DIFFERENTIATION": "mir-124 predicted interactions with cell cycle and differentiation", "WP_MIR5093P_ALTERATION_OF_YAP1ECM_AXIS": "miR-509-3p alteration of YAP1/ECM axis", "WP_MIR517_RELATIONSHIP_WITH_ARCN1_AND_USP1": "miR-517 relationship with ARCN1 and USP1", "WP_MIRNAS_INVOLVED_IN_DNA_DAMAGE_RESPONSE": "miRNAs involved in DNA damage response", "WP_MIRNA_BIOGENESIS": "miRNA biogenesis", "WP_MIRNA_REGULATION_OF_P53_PATHWAY_IN_PROSTATE_CANCER": "miRNA regulation of p53 pathway in prostate cancer", "WP_MIRNA_REGULATION_OF_DNA_DAMAGE_RESPONSE": "miRNA regulation of DNA damage response", "WP_MITOCHONDRIAL_BETAOXIDATION": "Mitochondrial beta-oxidation", "WP_MIRNA_ROLE_IN_IMMUNE_RESPONSE_IN_SEPSIS": "miRNA role in immune response in sepsis", "WP_MIRNA_REGULATION_OF_PROSTATE_CANCER_SIGNALING": "miRNA regulation of prostate cancer signaling", "WP_MITOCHONDRIAL_COMPLEX_III_ASSEMBLY": "Mitochondrial complex III assembly", "WP_MITOCHONDRIAL_COMPLEX_II_ASSEMBLY": "Mitochondrial complex II assembly", "WP_MIRNA_TARGETS_IN_ECM_AND_MEMBRANE_RECEPTORS": "miRNA targets in ECM and membrane receptors", "WP_MITOCHONDRIAL_COMPLEX_IV_ASSEMBLY": "Mitochondrial complex IV assembly", "WP_MITOCHONDRIAL_COMPLEX_I_ASSEMBLY_MODEL_OXPHOS_SYSTEM": "Mitochondrial complex I assembly model OXPHOS system", "WP_MITOCHONDRIAL_FATTY_ACID_OXIDATION_DISORDERS": "Mitochondrial fatty acid oxidation disorders", "WP_MITOCHONDRIAL_FATTY_ACID_SYNTHESIS_AND_RESPIRATION": "", "WP_MITOCHONDRIAL_FATTY_ACID_SYNTHESIS_PATHWAY": "Mitochondrial fatty acid synthesis pathway", "WP_MITOCHONDRIAL_GENE_EXPRESSION": "Mitochondrial gene expression", "WP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION": "Mitochondrial long chain fatty acid beta-oxidation", "WP_MODULATION_OF_PI3KAKTMTOR_SIGNALING_BY_BIOACTIVE_SPHINGOLIPIDS": "Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids", "WP_MITOCHONDRIAL_IMMUNE_RESPONSE_TO_SARSCOV2": "Mitochondrial immune response to SARS-CoV-2", "WP_MODULATORS_OF_TCR_SIGNALING_AND_T_CELL_ACTIVATION": "Modulators of TCR signaling and T cell activation", "WP_MOLYBDENUM_COFACTOR_MOCO_BIOSYNTHESIS": "Molybdenum cofactor (Moco) biosynthesis", "WP_MONOAMINE_TRANSPORT": "Monoamine transport", "WP_MONOAMINE_GPCRS": "Monoamine GPCRs", "WP_MRNA_PROTEIN_AND_METABOLITE_INDUCATION_PATHWAY_BY_CYCLOSPORIN_A": "", "WP_MRNA_PROCESSING": "mRNA processing", "WP_MRNA_VACCINE_ACTIVATION_OF_DENDRITIC_CELL_AND_INDUCTION_OF_IFN1": "mRNA vaccine activation of dendritic cell and induction of IFN-1", "WP_MTHFR_DEFICIENCY": "MTHFR deficiency", "WP_MULTIPLE_EPIPHYSEAL_DYSPLASIA_AND_PSEUDOACHONDROPLASIA_GENES": "Multiple epiphyseal dysplasia and pseudoachondroplasia genes", "WP_MYD88_DISTINCT_INPUTOUTPUT_PATHWAY": "MYD88 distinct input-output pathway", "WP_NAD_BIOSYNTHETIC_PATHWAYS": "NAD+ biosynthetic pathways", "WP_NAD_BIOSYNTHESIS_II_FROM_TRYPTOPHAN": "NAD biosynthesis II from tryptophan", "WP_NAD_METABOLISM": "NAD+ metabolism", "WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS": "Myometrial relaxation and contraction pathways", "WP_NAD_METABOLISM_IN_ONCOGENEINDUCED_SENESCENCE_AND_MITOCHONDRIAL_DYSFUNCTIONASSOCIATED_SENESCENCE": "NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence", "WP_NAD_METABOLISM_SIRTUINS_AND_AGING": "NAD metabolism, sirtuins and aging", "WP_NANOMATERIALINDUCED_INFLAMMASOME_ACTIVATION": "Nanomaterial-induced inflammasome activation", "WP_NANOMATERIAL_INDUCED_APOPTOSIS": "Nanomaterial induced apoptosis", "WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING": "Nanoparticle-mediated activation of receptor signaling", "WP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH": "Nanoparticle triggered autophagic cell death", "WP_NANOPARTICLE_TRIGGERED_REGULATED_NECROSIS": "Nanoparticle triggered regulated necrosis", "WP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA": "", "WP_NEOLACTO_SERIES_SPHINGOLIPID_METABOLISM": "Neolacto series sphingolipid metabolism", "WP_NCRNAS_INVOLVED_IN_STAT3_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA": "ncRNAs involved in STAT3 signaling in hepatocellular carcinoma", "WP_NEPHROGENESIS": "Nephrogenesis", "WP_NEOVASCULARIZATION_PROCESSES": "Neovascularization processes", "WP_NETRINUNC5B_SIGNALING": "Netrin-UNC5B signaling", "WP_NEPHROTIC_SYNDROME": "Nephrotic syndrome", "WP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT": "Neural crest cell migration during development", "WP_NEURAL_CREST_CELL_MIGRATION_IN_CANCER": "Neural crest cell migration in cancer", "WP_NETWORK_MAP_OF_SARSCOV2_SIGNALING": "Network map of SARS-CoV-2 signaling", "WP_NEUROINFLAMMATION": "Neuroinflammation", "WP_NEURAL_CREST_DIFFERENTIATION": "Neural crest differentiation", "WP_NEURODEGENERATION_WITH_BRAIN_IRON_ACCUMULATION_NBIA_SUBTYPES_PATHWAY": "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway", "WP_NEUROGENESIS_REGULATION_IN_THE_OLFACTORY_EPITHELIUM": "Neurogenesis regulation in the olfactory epithelium", "WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING": "Neuroinflammation and glutamatergic signaling", "WP_NEUROTRANSMITTER_DISORDERS": "Neurotransmitter disorders", "WP_NICOTINE_METABOLISM_IN_LIVER_CELLS": "Nicotine metabolism in liver cells", "WP_NF1_COPY_NUMBER_VARIATION_SYNDROME": "NF1 copy number variation syndrome", "WP_NGLYCAN_BIOSYNTHESIS": "N-glycan biosynthesis", "WP_NICOTINE_EFFECT_ON_DOPAMINERGIC_NEURONS": "Nicotine effect on dopaminergic neurons", "WP_NIPBL_ROLE_IN_DNA_DAMAGE_CORNELIA_DE_LANGE_SYNDROME": "NIPBL role in DNA damage - Cornelia de Lange syndrome", "WP_NITRIC_OXIDE_METABOLISM_IN_CYSTIC_FIBROSIS": "Nitric oxide metabolism in cystic fibrosis", "WP_NODLIKE_RECEPTOR_NLR_SIGNALING": "Nod-like receptor (NLR) signaling", "WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION": "NO/cGMP/PKG mediated neuroprotection", "WP_NONCLASSICAL_ROLE_OF_VITAMIN_D": "Non-classical role of vitamin D", "WP_NONHOMOLOGOUS_END_JOINING": "Non-homologous end joining", "WP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3": "", "WP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION": "NOTCH1 regulation of endothelial cell calcification", "WP_NONALCOHOLIC_FATTY_LIVER_DISEASE": "Nonalcoholic fatty liver disease", "WP_NONSMALL_CELL_LUNG_CANCER": "Non-small cell lung cancer", "WP_NOTCH_SIGNALING_WP61": "Notch signaling", "WP_NOTCH_SIGNALING_WP268": "Notch signaling", "WP_NRF2ARE_REGULATION": "NRF2-ARE regulation", "WP_NPHP1_DELETION_SYNDROME": "NPHP1 deletion syndrome", "WP_NOVEL_INTRACELLULAR_COMPONENTS_OF_RIGILIKE_RECEPTOR_PATHWAY": "Novel intracellular components of RIG-I-like receptor pathway", "WP_NRXN1_DELETION_SYNDROME": "NRXN1 deletion syndrome", "WP_NSP1_FROM_SARSCOV2_INHIBITS_TRANSLATION_INITIATION_IN_THE_HOST_CELL": "nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell", "WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER": "NRP1-triggered signaling in pancreatic cancer", "WP_NRF2_PATHWAY": "NRF2 pathway", "WP_NUCLEAR_RECEPTORS": "Nuclear receptors", "WP_NUCLEOTIDE_EXCISION_REPAIR": "Nucleotide excision repair", "WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY": "Nuclear receptors in lipid metabolism and toxicity", "WP_NUCLEOTIDE_GPCRS": "Nucleotide GPCRs", "WP_NUCLEOTIDEBINDING_OLIGOMERIZATION_DOMAIN_NOD_PATHWAY": "Nucleotide-binding oligomerization domain (NOD) pathway", "WP_NUCLEAR_RECEPTORS_METAPATHWAY": "Nuclear receptors meta-pathway", "WP_NUCLEOTIDE_EXCISION_REPAIR_IN_XERODERMA_PIGMENTOSUM": "Nucleotide excision repair in xeroderma pigmentosum", "WP_OCTADECANOID_FORMATION_FROM_LINOLEIC_ACID": "Octadecanoid formation from linoleic acid", "WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS": "Omega-3 / omega-6 fatty acid synthesis", "WP_OLIGODENDROCYTE_SPECIFICATION_AND_DIFFERENTIATION_LEADING_TO_MYELIN_COMPONENTS_FOR_CNS": "Oligodendrocyte specification and differentiation, leading to myelin components for CNS", "WP_OMEGA6FATTY_ACIDS_IN_SENESCENCE": "Omega-6-fatty acids in senescence", "WP_OMEGA9_FATTY_ACID_SYNTHESIS": "Omega-9 fatty acid synthesis", "WP_ONECARBON_METABOLISM": "One-carbon metabolism", "WP_ONCOSTATIN_M_SIGNALING": "Oncostatin M signaling", "WP_OPIOID_RECEPTOR_PATHWAYS": "Opioid receptor pathways", "WP_OSTEOARTHRITIC_CHONDROCYTE_HYPERTROPHY": "Osteoarthritic chondrocyte hypertrophy", "WP_OSTEOBLAST_SIGNALING": "Osteoblast signaling", "WP_OREXIN_RECEPTOR_PATHWAY": "Orexin receptor pathway", "WP_OSTEOCLAST_SIGNALING": "Osteoclast signaling", "WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES": "Osteoblast differentiation and related diseases", "WP_OSTEOPONTIN_SIGNALING": "Osteopontin signaling", "WP_OSX_AND_MIRNAS_IN_TOOTH_DEVELOPMENT": "OSX and miRNAs in tooth development", "WP_OVERVIEW_OF_NANOPARTICLE_EFFECTS": "Overview of nanoparticle effects", "WP_OVARIAN_INFERTILITY": "Ovarian infertility", "WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES": "Overlap between signal transduction pathways contributing to LMNA laminopathies", "WP_OVERVIEW_OF_PROINFLAMMATORY_AND_PROFIBROTIC_MEDIATORS": "Overview of proinflammatory and profibrotic mediators", "WP_OXIDATION_BY_CYTOCHROME_P450": "Oxidation by cytochrome P450", "WP_OXIDATIVE_PHOSPHORYLATION": "Oxidative phosphorylation", "WP_OXIDATIVE_STRESS_RESPONSE": "Oxidative stress response", "WP_OXIDATIVE_DAMAGE_RESPONSE": "Oxidative damage response", "WP_OXYSTEROLS_DERIVED_FROM_CHOLESTEROL": "Oxysterols derived from cholesterol", "WP_P38_MAPK_SIGNALING": "p38 MAPK signaling", "WP_PAFAH1B1_COPY_NUMBER_VARIATION": "PAFAH1B1 copy number variation", "WP_P53_TRANSCRIPTIONAL_GENE_NETWORK": "p53 transcriptional gene network", "WP_PANCREATIC_ADENOCARCINOMA_PATHWAY": "Pancreatic adenocarcinoma pathway", "WP_PATHOGENESIS_OF_SARSCOV2_MEDIATED_BY_NSP9NSP10_COMPLEX": "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex", "WP_PANCREATIC_CANCER_SUBTYPES": "Pancreatic cancer subtypes", "WP_PARKINSONS_DISEASE_PATHWAY": "Parkinson's disease pathway", "WP_PATHOPHYSIOLOGICAL_ROLES_OF_DUX4_IN_FSHD1": "Pathophysiological roles of DUX4 in FSHD1", "WP_PATHOGENIC_ESCHERICHIA_COLI_INFECTION": "Pathogenic Escherichia coli infection", "WP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA": "Pathways affected in adenoid cystic carcinoma", "WP_PARKINUBIQUITIN_PROTEASOMAL_SYSTEM_PATHWAY": "Parkin-ubiquitin proteasomal system pathway", "WP_PDGFRBETA_PATHWAY": "PDGFR-beta pathway", "WP_PATHWAYS_OF_NUCLEIC_ACID_METABOLISM_AND_INNATE_IMMUNE_SENSING": "Pathways of nucleic acid metabolism and innate immune sensing", "WP_PDGF_PATHWAY": "PDGF pathway", "WP_PENTOSE_PHOSPHATE_METABOLISM": "Pentose phosphate metabolism", "WP_PENTOSE_PHOSPHATE_PATHWAY_IN_SENESCENT_CELLS": "Pentose phosphate pathway in senescent cells", "WP_PEROXIREDOXIN_2_INDUCED_OVARIAN_FAILURE": "Peroxiredoxin 2 induced ovarian failure", "WP_PEPTIDE_GPCRS": "Peptide GPCRs", "WP_PGK1_PKM2_KHKCKHKA_ACTING_AS_PROTEIN_KINASES": "PGK1, PKM2, KHKC/KHKA acting as protein kinases", "WP_PHASE_I_BIOTRANSFORMATIONS_NONP450": "Phase I biotransformations, non-P450", "WP_PERTURBATIONS_TO_HOSTCELL_AUTOPHAGY_INDUCED_BY_SARSCOV2_PROTEINS": "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins", "WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY": "Phosphatidyl inositol phosphate pathway", "WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING": "Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling", "WP_PHOSPHOINOSITIDES_METABOLISM": "Phosphoinositides metabolism", "WP_PHOTODYNAMIC_THERAPYINDUCED_HIF1_SURVIVAL_SIGNALING": "Photodynamic therapy-induced HIF-1 survival signaling", "WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION": "Phosphodiesterases in neuronal function", "WP_PHOTODYNAMIC_THERAPYINDUCED_AP1_SURVIVAL_SIGNALING": "Photodynamic therapy-induced AP-1 survival signaling", "WP_PHOTODYNAMIC_THERAPYINDUCED_UNFOLDED_PROTEIN_RESPONSE": "Photodynamic therapy-induced unfolded protein response", "WP_PHOTODYNAMIC_THERAPYINDUCED_NFKB_SURVIVAL_SIGNALING": "Photodynamic therapy-induced NF-kB survival signaling", "WP_PHYSIOLOGICAL_AND_PATHOLOGICAL_HYPERTROPHY_OF_THE_HEART": "Physiological and pathological hypertrophy of the heart", "WP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS": "Physico-chemical features and toxicity-associated pathways", "WP_PI3KAKTMTOR_SIGNALING_AND_THERAPEUTIC_OPPORTUNITIES_IN_PROSTATE_CANCER": "PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer", "WP_PI3KAKTMTOR_VITAMIN_D3_SIGNALING": "PI3K/AKT/mTOR - vitamin D3 signaling", "WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA": "PKC-gamma calcium signaling in ataxia", "WP_PILOCYTIC_ASTROCYTOMA": "Pilocytic astrocytoma", "WP_PLATELETMEDIATED_INTERACTIONS_WITH_VASCULAR_AND_CIRCULATING_CELLS": "Platelet-mediated interactions with vascular and circulating cells", "WP_PI3KAKT_SIGNALING": "PI3K-Akt signaling", "WP_PLURIPOTENT_STEM_CELL_DIFFERENTIATION_PATHWAY": "Pluripotent stem cell differentiation pathway", "WP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY": "Polycystic kidney disease pathway", "WP_PPARALPHA_PATHWAY": "PPAR-alpha pathway", "WP_POSTCOVID_NEUROINFLAMMATION": "Post-COVID neuroinflammation", "WP_PLEURAL_MESOTHELIOMA": "Pleural mesothelioma", "WP_PREGNANE_X_RECEPTOR_PATHWAY": "Pregnane X receptor pathway", "WP_PRADERWILLI_AND_ANGELMAN_SYNDROME": "Prader-Willi and Angelman syndrome", "WP_PREIMPLANTATION_EMBRYO": "Pre-implantation embryo", "WP_PPAR_SIGNALING": "PPAR signaling", "WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS": "Primary focal segmental glomerulosclerosis (FSGS)", "WP_PRION_DISEASE_PATHWAY": "Prion disease pathway", "WP_PROGERIAASSOCIATED_LIPODYSTROPHY": "Progeria-associated lipodystrophy", "WP_PROLACTIN_SIGNALING": "Prolactin signaling", "WP_PRIMARY_OVARIAN_INSUFFICIENCY": "Primary ovarian insufficiency", "WP_PROLINE_AND_HYDROXYPROLINE_PATHWAYS": "Proline and hydroxyproline pathways", "WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5122": "", "WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5321": "", "WP_PROSTAGLANDIN_SIGNALING": "Prostaglandin signaling", "WP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION": "Prostaglandin synthesis and regulation", "WP_PROSURVIVAL_SIGNALING_OF_NEUROPROTECTIN_D1": "Pro-survival signaling of neuroprotectin D1", "WP_PROTEOGLYCAN_BIOSYNTHESIS": "Proteoglycan biosynthesis", "WP_PROTEASOME_DEGRADATION": "Proteasome degradation", "WP_PTF1A_RELATED_REGULATORY_PATHWAY": "PTF1A related regulatory pathway", "WP_PTDINS45P2_IN_CYTOKINESIS_PATHWAY": "PtdIns(4,5)P2 in cytokinesis pathway", "WP_PURINERGIC_SIGNALING": "Purinergic signaling", "WP_PURINE_METABOLISM": "Purine metabolism", "WP_PROXIMAL_TUBULE_TRANSPORT": "Proximal tubule transport", "WP_PURINE_METABOLISM_AND_RELATED_DISORDERS": "Purine metabolism and related disorders", "WP_PYRIMIDINE_METABOLISM": "Pyrimidine metabolism", "WP_PYRIMIDINE_METABOLISM_AND_RELATED_DISEASES": "Pyrimidine metabolism and related diseases", "WP_QUERCETIN_AND_NFKB_AP1_INDUCED_APOPTOSIS": "Quercetin and Nf-kB / AP-1 induced apoptosis", "WP_RALA_DOWNSTREAM_REGULATED_GENES": "RalA downstream regulated genes", "WP_RAC1PAK1P38MMP2_PATHWAY": "RAC1/PAK1/p38/MMP2 pathway", "WP_RAS_AND_BRADYKININ_PATHWAYS_IN_COVID19": "", "WP_RANKLRANK_SIGNALING": "RANKL/RANK signaling", "WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS": "Regucalcin in proximal tubule epithelial kidney cells", "WP_REGULATION_OF_APOPTOSIS_BY_PARATHYROID_HORMONERELATED_PROTEIN": "", "WP_RAS_SIGNALING": "Ras signaling", "WP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS": "Regulation of Wnt / B-catenin signaling by small molecule compounds", "WP_REGULATION_OF_SISTER_CHROMATID_SEPARATION_AT_THE_METAPHASEANAPHASE_TRANSITION": "Regulation of sister chromatid separation at the metaphase-anaphase transition", "WP_REGULATION_OF_ACTIN_CYTOSKELETON": "Regulation of actin cytoskeleton", "WP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR": "Relationship between inflammation, COX-2 and EGFR", "WP_REGULATORY_CIRCUITS_OF_STAT3_SIGNALING": "Regulatory circuits of STAT3 signaling", "WP_RESOLVIN_E1_AND_RESOLVIN_D1_SIGNALING_DECREASE_INFLAMMATION": "Resolvin E1 and resolvin D1 signaling decrease inflammation", "WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION": "Resistin as a regulator of inflammation", "WP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS": "Renin-angiotensin-aldosterone system (RAAS)", "WP_RETINOL_METABOLISM": "Retinol metabolism", "WP_RIBOFLAVIN_AND_COQ_DISORDERS": "Riboflavin and CoQ disorders", "WP_RETINOBLASTOMA_GENE_IN_CANCER": "Retinoblastoma gene in cancer", "WP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS": "RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis", "WP_RETT_SYNDROME": "Rett syndrome", "WP_ROBO4_AND_VEGF_SIGNALING_CROSSTALK": "ROBO4 and VEGF signaling crosstalk", "WP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION": "S1P receptor signal transduction", "WP_ROLES_OF_CERAMIDES_IN_DEVELOPMENT_OF_INSULIN_RESISTANCE": "Roles of ceramides in development of insulin resistance", "WP_ROS_IN_COVID19_ENDOTHELIAL_DYSFUNCTION": "ROS in COVID-19 endothelial dysfunction", "WP_RUBINSTEINTAYBI_SYNDROME_1": "Rubinstein-Taybi syndrome 1", "WP_SARSCOV2_AND_ACE2_RECEPTOR_MOLECULAR_MECHANISMS": "SARS-CoV-2 and ACE2 receptor: molecular mechanisms", "WP_SARSCOV2_ALTERING_ANGIOGENESIS_VIA_NRP1": "SARS-CoV-2 altering angiogenesis via NRP1", "WP_SARSCOV2_AND_COVID19_PATHWAY": "SARS-CoV-2 and COVID-19 pathway", "WP_SARSCOV2_B117_VARIANT_ANTAGONISES_INNATE_IMMUNE_ACTIVATION": "SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation", "WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE": "SARS-CoV-2 innate immunity evasion and cell-specific immune response", "WP_SARSCOV2_MITOCHONDRIAL_CHRONIC_OXIDATIVE_STRESS_AND_ENDOTHELIAL_DYSFUNCTION": "SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction", "WP_SEBALEIC_ACID_FORMATION_AND_METABOLISM": "Sebaleic acid formation and metabolism", "WP_SARS_CORONAVIRUS_AND_INNATE_IMMUNITY": "SARS coronavirus and innate immunity", "WP_SECRETION_OF_HYDROCHLORIC_ACID_IN_PARIETAL_CELLS": "Secretion of hydrochloric acid in parietal cells", "WP_SCFA_AND_SKELETAL_MUSCLE_SUBSTRATE_METABOLISM": "SCFA and skeletal muscle substrate metabolism", "WP_SELECTIVE_EXPRESSION_OF_CHEMOKINE_RECEPTORS_DURING_TCELL_POLARIZATION": "Selective expression of chemokine receptors during T-cell polarization", "WP_SELENIUM_METABOLISM_AND_SELENOPROTEINS": "Selenium metabolism and selenoproteins", "WP_SELENIUM_MICRONUTRIENT_NETWORK": "Selenium micronutrient network", "WP_SENESCENCEASSOCIATED_SECRETORY_PHENOTYPE_SASP": "Senescence-associated secretory phenotype (SASP)", "WP_SERINE_METABOLISM": "Serine metabolism", "WP_SEROTONIN_AND_ANXIETY": "Serotonin and anxiety", "WP_SEROTONIN_AND_ANXIETYRELATED_EVENTS": "Serotonin and anxiety-related events", "WP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING": "Serotonin receptor 2 and ELK-SRF/GATA4 signaling", "WP_SEROTONIN_TRANSPORTER_ACTIVITY": "Serotonin transporter activity", "WP_SEROTONIN_RECEPTOR_467_AND_NR3C_SIGNALING": "Serotonin receptor 4/6/7 and NR3C signaling", "WP_SEROTONIN_HTR1_GROUP_AND_FOS_PATHWAY": "Serotonin HTR1 group and FOS pathway", "WP_SILDENAFIL_TREATMENT": "Sildenafil treatment", "WP_SIGNAL_TRANSDUCTION_THROUGH_IL1R": "Signal transduction through IL1R", "WP_SMALL_LIGAND_GPCRS": "Small ligand GPCRs", "WP_SLEEP_REGULATION": "Sleep regulation", "WP_SMC1SMC3_ROLE_IN_DNA_DAMAGE_CORNELIA_DE_LANGE_SYNDROME": "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome", "WP_SMALL_CELL_LUNG_CANCER": "Small cell lung cancer", "WP_SOMATIC_SEX_DETERMINATION": "Somatic sex determination", "WP_SOMATROPH_AXIS_GH_AND_ITS_RELATIONSHIP_TO_DIETARY_RESTRICTION_AND_AGING": "Somatroph axis (GH) and its relationship to dietary restriction and aging", "WP_SOMITOGENESIS_IN_THE_CONTEXT_OF_SPONDYLOCOSTAL_DYSOSTOSIS": "Somitogenesis in the context of spondylocostal dysostosis", "WP_SPHINGOLIPID_METABOLISM_IN_SENESCENCE": "Sphingolipid metabolism in senescence", "WP_SMITHMAGENIS_AND_POTOCKILUPSKI_SYNDROME_COPY_NUMBER_VARIATION": "Smith-Magenis and Potocki-Lupski syndrome copy number variation", "WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY": "Sphingolipid metabolism: integrated pathway", "WP_SPHINGOLIPID_METABOLISM_OVERVIEW": "Sphingolipid metabolism overview", "WP_SPHINGOLIPID_PATHWAY": "Sphingolipid pathway", "WP_SPINA_BIFIDA": "Spina bifida", "WP_SPINAL_CORD_INJURY": "Spinal cord injury", "WP_SPLICING_FACTOR_NOVA_REGULATED_SYNAPTIC_PROTEINS": "Splicing factor NOVA regulated synaptic proteins", "WP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS": "SREBF and miR33 in cholesterol and lipid homeostasis", "WP_SRF_AND_MIRS_IN_SMOOTH_MUSCLE_DIFFERENTIATION_AND_PROLIFERATION": "SRF and miRs in smooth muscle differentiation and proliferation", "WP_STEROID_BIOSYNTHESIS": "Steroid biosynthesis", "WP_STEROID_HORMONE_PRECURSOR_BIOSYNTHESIS": "Steroid hormone precursor biosynthesis", "WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION": "Statin inhibition of cholesterol production", "WP_STING_PATHWAY_IN_KAWASAKILIKE_DISEASE_AND_COVID19": "STING pathway in Kawasaki-like disease and COVID-19", "WP_STEROL_REGULATORY_ELEMENTBINDING_PROTEINS_SREBP_SIGNALING": "Sterol regulatory element-binding proteins (SREBP) signaling", "WP_STRIATED_MUSCLE_CONTRACTION_PATHWAY": "Striated muscle contraction pathway", "WP_SULFATASE_AND_AROMATASE_PATHWAY": "Sulfatase and aromatase pathway", "WP_SULFATION_BIOTRANSFORMATION_REACTION": "Sulfation biotransformation reaction", "WP_SUDDEN_INFANT_DEATH_SYNDROME_SIDS_SUSCEPTIBILITY_PATHWAYS": "Sudden infant death syndrome (SIDS) susceptibility pathways", "WP_SULINDAC_METABOLIC_PATHWAY": "Sulindac metabolic pathway", "WP_SUPPRESSION_OF_HMGB1MEDIATED_INFLAMMATION_BY_THBD": "Suppression of HMGB1-mediated inflammation by THBD", "WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES": "Synthesis of ceramides and 1-deoxyceramides", "WP_SYNAPTIC_VESICLE_PATHWAY": "Synaptic vesicle pathway", "WP_TAMOXIFEN_METABOLISM": "Tamoxifen metabolism", "WP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER": "Synaptic signaling associated with autism spectrum disorder", "WP_TARGET_OF_RAPAMYCIN_SIGNALING": "Target of rapamycin signaling", "WP_TCA_CYCLE_AND_DEFICIENCY_OF_PYRUVATE_DEHYDROGENASE_COMPLEX_PDHC": "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)", "WP_TCA_CYCLE_AKA_KREBS_OR_CITRIC_ACID_CYCLE": "TCA cycle (aka Krebs or citric acid cycle)", "WP_TAR_SYNDROME": "TAR syndrome", "WP_TCA_CYCLE_IN_SENESCENCE": "TCA cycle in senescence", "WP_TCA_CYCLE_NUTRIENT_USE_AND_INVASIVENESS_OF_OVARIAN_CANCER": "TCA cycle nutrient use and invasiveness of ovarian cancer", "WP_TCELL_ANTIGEN_RECEPTOR_TCR_PATHWAY_DURING_STAPHYLOCOCCUS_AUREUS_INFECTION": "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection", "WP_TCELL_RECEPTOR_SIGNALING": "T-cell receptor signaling", "WP_TCELL_ACTIVATION_SARSCOV2": "T-cell activation SARS-CoV-2", "WP_TGFBETA_RECEPTOR_SIGNALING": "TGF-beta receptor signaling", "WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION": "TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition", "WP_TGFB_SMAD_SIGNALING": "TGFB / Smad signaling", "WP_TGIF_DISRUPTION_OF_SHH_SIGNALING": "Tgif disruption of Shh signaling", "WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS": "TGF-beta receptor signaling in skeletal dysplasias", "WP_TH17_CELL_DIFFERENTIATION_PATHWAY": "Th17 cell differentiation pathway", "WP_THERMOGENESIS": "Thermogenesis", "WP_THIAMINE_METABOLIC_PATHWAYS": "Thiamine metabolic pathways", "WP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING": "Thymic stromal lymphopoietin (TSLP) signaling", "WP_THYROID_STIMULATING_HORMONE_TSH_SIGNALING": "Thyroid stimulating hormone (TSH) signaling", "WP_THYROXINE_THYROID_HORMONE_PRODUCTION": "Thyroxine (thyroid hormone) production", "WP_TLR4_SIGNALING_AND_TOLERANCE": "TLR4 signaling and tolerance", "WP_THYROID_HORMONES_PRODUCTION_AND_PERIPHERAL_DOWNSTREAM_SIGNALING_EFFECTS": "Thyroid hormones production and peripheral downstream signaling effects", "WP_TNFALPHA_SIGNALING": "TNF-alpha signaling", "WP_TNFRELATED_WEAK_INDUCER_OF_APOPTOSIS_TWEAK_SIGNALING": "TNF-related weak inducer of apoptosis (TWEAK) signaling", "WP_TOLLLIKE_RECEPTOR_SIGNALING_RELATED_TO_MYD88": "Toll-like receptor signaling related to MyD88", "WP_TP53_NETWORK": "TP53 network", "WP_TOLLLIKE_RECEPTOR_SIGNALING": "Toll-like receptor signaling", "WP_TRANSCRIPTION_COFACTORS_SKI_AND_SKIL_PROTEIN_PARTNERS": "Transcription co-factors SKI and SKIL protein partners", "WP_TRANSCRIPTIONAL_ACTIVATION_BY_NRF2_IN_RESPONSE_TO_PHYTOCHEMICALS": "Transcriptional activation by NRF2 in response to phytochemicals", "WP_TRANSCRIPTIONAL_CASCADE_REGULATING_ADIPOGENESIS": "Transcriptional cascade regulating adipogenesis", "WP_TRANSCRIPTION_FACTORS_REGULATE_MIRNAS_RELATED_TO_CARDIAC_HYPERTROPHY": "Transcription factors regulate miRNAs related to cardiac hypertrophy", "WP_TRANSCRIPTION_FACTOR_REGULATION_IN_ADIPOGENESIS": "Transcription factor regulation in adipogenesis", "WP_TRANSLATION_FACTORS": "Translation factors", "WP_TRANSSULFURATION_PATHWAY": "Trans-sulfuration pathway", "WP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS": "Translation inhibitors in chronically activated PDGFRA cells", "WP_TRANSSULFURATION_ONECARBON_METABOLISM_AND_RELATED_PATHWAYS": "Trans-sulfuration, one-carbon metabolism and related pathways", "WP_TRIACYLGLYCERIDE_SYNTHESIS": "Triacylglyceride synthesis", "WP_TRYPTOPHAN_CATABOLISM_LEADING_TO_NAD_PRODUCTION": "Tryptophan catabolism leading to NAD+ production", "WP_TRYPTOPHAN_METABOLISM": "Tryptophan metabolism", "WP_TROP2_REGULATORY_SIGNALING": "TROP2 regulatory signaling", "WP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA": "Type 2 papillary renal cell carcinoma", "WP_TUMOR_SUPPRESSOR_ACTIVITY_OF_SMARCB1": "Tumor suppressor activity of SMARCB1", "WP_TYPE_III_INTERFERON_SIGNALING": "Type III interferon signaling", "WP_TYPE_II_DIABETES_MELLITUS": "Type II diabetes mellitus", "WP_TYPE_I_COLLAGEN_SYNTHESIS_IN_THE_CONTEXT_OF_OSTEOGENESIS_IMPERFECTA": "Type I collagen synthesis in the context of osteogenesis imperfecta", "WP_TYPE_II_INTERFERON_SIGNALING": "Type II interferon signaling", "WP_T_CELL_MODULATION_IN_PANCREATIC_CANCER": "", "WP_TYROSINE_METABOLISM_AND_RELATED_DISORDERS": "Tyrosine metabolism and related disorders", "WP_TYROBP_CAUSAL_NETWORK_IN_MICROGLIA": "TYROBP causal network in microglia", "WP_TYPE_I_INTERFERON_INDUCTION_AND_SIGNALING_DURING_SARSCOV2_INFECTION": "Type I interferon induction and signaling during SARS-CoV-2 infection", "WP_UDPDERIVED_SUGARS_SYNTHESIS_IN_FIBROBLASTS": "UDP-derived sugars synthesis in fibroblasts", "WP_T_CELL_RECEPTOR_AND_COSTIMULATORY_SIGNALING": "T cell receptor and co-stimulatory signaling", "WP_ULCERATIVE_COLITIS_SIGNALING": "Ulcerative colitis signaling", "WP_UNFOLDED_PROTEIN_RESPONSE": "Unfolded protein response", "WP_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS": "Urea cycle and metabolism of amino groups", "WP_UREA_CYCLE_AND_ASSOCIATED_PATHWAYS": "Urea cycle and associated pathways", "WP_UREA_CYCLE_AND_RELATED_DISEASES": "Urea cycle and related diseases", "WP_VALPROIC_ACID_PATHWAY": "Valproic acid pathway", "WP_VITAMIN_A1_AND_A5X_PATHWAYS": "Vitamin A1 and A5/X pathways", "WP_VASOPRESSINREGULATED_WATER_REABSORPTION": "Vasopressin-regulated water reabsorption", "WP_UROTENSINIIMEDIATED_SIGNALING": "Urotensin-II-mediated signaling", "WP_VITAMIN_A_AND_CAROTENOID_METABOLISM": "Vitamin A and carotenoid metabolism", "WP_VITAMIN_B12_DISORDERS": "Vitamin B12 disorders", "WP_VITAMIN_B6DEPENDENT_AND_RESPONSIVE_DISORDERS": "Vitamin B6-dependent and responsive disorders", "WP_VEGFAVEGFR2_SIGNALING": "VEGFA-VEGFR2 signaling", "WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES": "Vitamin D in inflammatory diseases", "WP_VITAMIN_B12_METABOLISM": "Vitamin B12 metabolism", "WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION": "Vitamin D-sensitive calcium signaling in depression", "WP_VITAMIN_D_METABOLISM": "Vitamin D metabolism", "WP_VITAMIN_K_METABOLISM_AND_ACTIVATION_OF_DEPENDENT_PROTEINS": "Vitamin K metabolism and activation of dependent proteins", "WP_WARBURG_EFFECT_MODULATED_BY_DEUBIQUITINATING_ENZYMES_AND_THEIR_SUBSTRATES": "Warburg effect modulated by deubiquitinating enzymes and their substrates", "WP_WHITE_FAT_CELL_DIFFERENTIATION": "White fat cell differentiation", "WP_VITAMIN_D_RECEPTOR_PATHWAY": "Vitamin D receptor pathway", "WP_WNTBETACATENIN_SIGNALING_INHIBITORS_IN_CURRENT_AND_PAST_CLINICAL_TRIALS": "Wnt/Beta-catenin signaling inhibitors in current and past clinical trials", "WP_WNTBETACATENIN_SIGNALING_IN_LEUKEMIA": "Wnt/beta-catenin signaling in leukemia", "WP_WNT_SIGNALING_AND_PLURIPOTENCY": "Wnt signaling and pluripotency", "WP_WNT_SIGNALING_WP363": "", "WP_WNT_SIGNALING_IN_KIDNEY_DISEASE": "Wnt signaling in kidney disease", "WP_WNT_SIGNALING_WP428": "", "WP_ZINC_HOMEOSTASIS": "Zinc homeostasis", "LET_7B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7A_5P_LET_7C_5P_LET_7E_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7a-5p, hsa-let-7c-5p, hsa-let-7e-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7A_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7a-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7E_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7e-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7D_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7d-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7D_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7d-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7F_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7f-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7F_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7f-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7I_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7i-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7G_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7g-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7F_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7f-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7G_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7g-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR100_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-100-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR100_5P_MIR99A_5P_MIR99B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-100-5p, hsa-miR-99a-5p, hsa-miR-99b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "LET_7I_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-let-7i-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR101_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-101-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR101_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-101-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10392_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10392-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR101_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-101-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10226": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10226 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10393_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10393-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10394_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10394-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10393_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10393-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10396A_3P_MIR10396B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10396a-3p, hsa-miR-10396b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10395_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10395-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10395_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10395-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10396A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10396a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10396B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10396b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10397_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10397-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10397_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10397-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10399_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10399-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10398_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10398-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10398_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10398-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR103A_1_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-103a-1-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10399_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10399-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR103A_3P_MIR107": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-103a-3p, hsa-miR-107 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR103A_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-103a-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR103B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-103b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10400_3P_MIR4674": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10400-3p, hsa-miR-4674 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10401_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10401-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10401_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10401-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10522_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10522-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10524_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10524-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10523_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10523-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10526_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10526-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10525_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10525-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR105_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-105-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10527_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10527-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR106A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-106a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR105_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-105-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10A_5P_MIR10B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10a-5p, hsa-miR-10b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR10B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-10b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR106A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-106a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR11181_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-11181-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR11181_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-11181-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR106B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-106b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR11399": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-11399 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR11400": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-11400 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR11401": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-11401 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1178_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1178-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1178_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1178-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1179": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1179 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1182": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1182 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1180_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1180-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1180_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1180-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1183": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1183 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1185_1_3P_MIR1185_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1185-1-3p, hsa-miR-1185-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1184": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1184 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1185_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1185-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1193": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1193 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1199_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1199-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1197": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1197 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1200": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1200 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1203": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1203 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1202": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1202 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1204": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1204 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1206": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1206 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1207_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1207-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1205": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1205 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1207_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1207-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12113": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12113 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1208": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1208 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12115": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12115 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12114": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12114 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12116": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12116 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12117": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12117 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12119": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12119 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12118": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12118 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12120": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12120 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12121": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12121 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12122": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12122 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12123": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12123 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12126": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12126 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12125": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12125 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12124": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12124 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12127": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12127 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12129": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12129 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12128": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12128 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12130": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12130 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12131": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12131 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12132": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12132 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12133": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12133 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1224_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1224-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1225_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1225-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12135": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12135 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1225_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1225-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1226_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1226-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1226_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1226-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR12136": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-12136 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1224_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1224-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1227_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1227-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1227_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1227-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1228_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1228-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1229_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1229-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1229_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1229-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR122_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-122-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR122B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-122b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR122B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-122b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1231": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1231 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR122_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-122-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1233_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1233-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1233_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1233-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1236_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1236-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1236_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1236-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1237_5P_MIR4488": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1237-5p, hsa-miR-4488 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1238_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1238-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1237_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1237-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1238_5P_MIR4758_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1238-5p, hsa-miR-4758-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1243": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1243 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1244": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1244 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1245A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1245a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1245B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1245b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1245B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1245b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1246": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1246 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1247_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1247-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1248": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1248 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1249_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1249-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1250_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1250-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR124_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-124-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR124_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-124-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1251_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1251-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1250_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1250-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1252_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1252-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1255A_MIR1255B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1255a, hsa-miR-1255b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1252_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1252-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1251_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1251-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1253": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1253 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1255B_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1255b-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1256": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1256 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1257": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1257 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR125A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-125a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1258": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1258 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1262": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1262 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1261": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1261 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1260A_MIR1260B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1260a, hsa-miR-1260b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR125B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-125b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR125B_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-125b-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR125A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-125a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1263": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1263 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1264": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1264 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1266_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1266-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1265": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1265 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1267": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1267 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1270": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1270 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1268A_MIR1268B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1268a, hsa-miR-1268b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1269A_MIR1269B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1269a, hsa-miR-1269b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1266_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1266-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR126_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-126-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1271_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1271-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1271_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1271-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1273C": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1273c in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1272": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1272 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1273H_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1273h-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1273H_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1273h-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1276": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1276 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1275": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1275 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR127_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-127-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1277_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1277-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1279": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1279 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1278": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1278 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1277_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1277-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR127_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-127-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1281": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1281 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1282": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1282 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1284": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1284 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1287_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1287-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1285_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1285-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1288_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1288-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1283": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1283 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1286": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1286 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1285_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1285-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1287_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1287-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1288_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1288-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1289": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1289 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR128_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-128-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR128_1_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-128-1-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1292_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1292-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1291": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1291 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1290": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1290 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1294": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1294 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR128_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-128-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1295B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1295b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1293": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1293 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1295B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1295b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1296_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1296-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1296_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1296-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1298_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1298-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1297": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1297 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1298_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1298-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR129_1_3P_MIR129_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-129-1-3p, hsa-miR-129-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1301_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1301-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1299": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1299 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1301_3P_MIR5047": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1301-3p, hsa-miR-5047 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR129_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-129-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1302": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1302 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1303": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1303 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1304_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1304-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1304_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1304-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR130A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-130a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1306_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1306-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR130A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-130a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR130B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-130b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1305": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1305 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1322": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1322 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR130B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-130b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1321": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1321 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1323": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1323 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1324": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1324 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1343_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1343-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR132_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-132-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR133A_3P_MIR133B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-133a-3p, hsa-miR-133b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR132_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-132-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR133A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-133a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR134_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-134-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1343_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1343-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR134_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-134-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR135A_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-135a-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR135A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-135a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR135B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-135b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR135A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-135a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR136_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-136-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR136_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-136-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR135B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-135b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR138_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-138-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR137_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-137-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR138_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-138-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR138_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-138-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR139_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-139-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR140_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-140-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR139_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-139-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR142_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-142-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR141_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-141-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR140_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-140-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR143_3P_MIR4770": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-143-3p, hsa-miR-4770 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR141_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-141-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR142_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-142-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR143_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-143-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR144_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-144-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR144_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-144-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR145_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-145-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR146A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-146a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1468_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1468-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR145_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-145-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR146B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-146b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1468_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1468-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR146A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-146a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR146B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-146b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1470": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1470 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR147A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-147a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR147B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-147b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR148A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-148a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR148A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-148a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR147B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-147b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR149_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-149-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR148B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-148b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR149_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-149-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR150_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-150-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR148B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-148b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR150_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-150-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR151A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-151a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR151A_5P_MIR151B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-151a-5p, hsa-miR-151b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR152_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-152-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR152_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-152-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1537_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1537-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR153_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-153-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1539": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1539 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1537_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1537-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR154_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-154-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR154_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-154-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR155_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-155-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR153_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-153-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR155_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-155-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR15A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-15a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1587": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1587 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR15B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-15b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR15A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-15a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR16_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-16-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR15B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-15b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR16_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-16-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR16_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-16-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR181A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-181a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR17_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-17-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR181A_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-181a-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR17_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-17-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR181B_2_3P_MIR181B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-181b-2-3p, hsa-miR-181b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR181A_5P_MIR181B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-181a-5p, hsa-miR-181b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR181C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-181c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR181C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-181c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1825": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1825 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR182_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-182-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR181D_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-181d-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR183_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-183-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1827": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1827 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR182_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-182-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR184": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-184 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR183_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-183-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1843": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1843 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR185_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-185-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR185_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-185-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR186_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-186-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR186_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-186-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR188_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-188-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR187_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-187-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR18A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-18a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR188_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-188-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR18A_5P_MIR18B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-18a-5p, hsa-miR-18b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR18B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-18b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1908_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1908-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1909_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1909-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1909_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1909-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR190B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-190b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR190A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-190a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1911_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1911-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1910_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1910-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1910_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1910-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR190B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-190b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1911_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1911-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1912_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1912-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1912_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1912-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1913": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1913 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1914_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1914-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1914_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1914-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1915_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1915-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR191_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-191-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1915_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1915-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR192_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-192-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR192_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-192-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR193A_3P_MIR193B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-193a-3p, hsa-miR-193b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR193A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-193a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR193B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-193b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR194_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-194-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR194_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-194-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR195_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-195-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR195_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-195-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR196A_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-196a-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR196A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-196a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1972": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1972 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1973": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1973 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR196A_5P_MIR196B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-196a-5p, hsa-miR-196b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR196B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-196b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1976": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1976 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR197_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-197-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR197_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-197-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR199A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-199a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR198": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-198 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR199A_3P_MIR199B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-199a-3p, hsa-miR-199b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR199B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-199b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR19A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-19a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR19A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-19a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR19B_1_5P_MIR19B_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-19b-1-5p, hsa-miR-19b-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR19B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-19b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR1_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-1-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR200A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-200a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR200A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-200a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR200B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-200b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR200B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-200b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR200C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-200c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR200C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-200c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR202_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-202-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR203A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-203a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR202_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-202-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR203B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-203b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR203A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-203a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR203B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-203b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR204_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-204-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR204_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-204-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2052": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2052 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2053": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2053 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2054": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2054 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR205_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-205-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR205_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-205-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR208A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-208a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR208A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-208a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR206": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-206 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR208B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-208b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR20B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-20b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR208B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-208b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR20A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-20a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR210_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-210-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR20A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-20a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR210_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-210-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR20B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-20b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2110": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2110 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2113": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2113 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2114_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2114-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2115_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2115-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2114_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2114-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2115_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2115-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2116_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2116-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2116_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2116-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR211_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-211-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2117": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2117 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR211_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-211-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR212_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-212-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR212_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-212-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR214_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-214-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR214_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-214-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR215_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-215-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR216A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-216a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR215_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-215-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR216A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-216a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR216B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-216b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR216B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-216b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR217_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-217-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR217_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-217-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR218_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-218-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR218_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-218-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR219A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-219a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR219A_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-219a-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR218_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-218-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR219A_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-219a-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR219B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-219b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR219B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-219b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR21_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-21-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR21_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-21-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR221_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-221-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR221_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-221-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR222_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-222-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR222_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-222-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR223_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-223-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR224_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-224-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR224_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-224-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2276_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2276-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR223_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-223-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2276_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2276-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2278": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2278 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2277_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2277-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR22_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-22-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR22_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-22-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2355_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2355-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2392": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2392 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2355_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2355-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR23B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-23b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR23A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-23a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR23A_3P_MIR23B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-23a-3p, hsa-miR-23b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2467_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2467-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR23C": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-23c in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR24_1_5P_MIR24_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-24-1-5p, hsa-miR-24-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR25_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-25-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2467_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2467-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR24_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-24-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR25_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-25-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2682_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2682-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2681_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2681-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2682_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2682-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR26A_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-26a-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR26A_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-26a-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2681_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2681-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR26B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-26b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR26A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-26a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR26B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-26b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR27A_3P_MIR27B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-27a-3p, hsa-miR-27b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR27A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-27a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR27B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-27b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2861": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2861 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR28_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-28-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR28_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-28-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR2909": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-2909 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR296_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-296-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR296_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-296-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR298": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-298 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR297": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-297 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR299_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-299-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR299_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-299-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR29A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-29a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR29A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-29a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR29B_1_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-29b-1-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR29B_3P_MIR29C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-29b-3p, hsa-miR-29c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR29B_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-29b-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR301A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-301a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR300": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-300 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR301A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-301a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR301B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-301b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR302A_3P_MIR302B_3P_MIR302C_3P_MIR302D_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-302a-3p, hsa-miR-302b-3p, hsa-miR-302c-3p, hsa-miR-302d-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR301B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-301b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR302B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-302b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR302A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-302a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR302D_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-302d-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR302C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-302c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR302F": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-302f in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR302E": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-302e in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3059_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3059-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3059_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3059-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3064_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3064-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3064_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3064-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3065_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3065-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3065_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3065-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3074_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3074-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3074_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3074-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3085_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3085-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3085_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3085-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30B_5P_MIR30C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30b-5p, hsa-miR-30c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30C_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30c-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30C_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30c-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30D_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30d-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30D_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30d-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30E_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30e-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR30E_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-30e-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3115": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3115 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3116": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3116 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3117_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3117-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3117_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3117-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3119": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3119 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3120_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3120-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3118": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3118 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3121_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3121-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3121_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3121-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3120_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3120-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3122": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3122 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3124_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3124-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3123": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3123 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3125": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3125 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3126_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3126-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3126_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3126-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3127_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3127-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3127_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3127-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3130_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3130-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3129_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3129-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3130_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3130-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3129_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3129-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3128": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3128 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3132": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3132 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3133": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3133 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3134": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3134 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3135A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3135a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3135B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3135b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3136_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3136-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3136_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3136-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3137": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3137 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3139": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3139 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3138": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3138 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3140_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3140-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3142": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3142 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3140_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3140-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3143": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3143 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3144_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3144-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3144_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3144-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3145_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3145-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3147": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3147 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3146": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3146 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3145_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3145-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3149": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3149 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3150A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3150a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3150B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3150b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3151_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3151-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3151_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3151-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3152_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3152-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3154": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3154 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3155A_MIR3155B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3155a, hsa-miR-3155b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3152_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3152-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3153": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3153 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3156_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3156-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3156_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3156-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3157_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3157-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3157_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3157-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3158_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3158-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3158_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3158-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3159": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3159 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3160_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3160-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3161": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3161 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3160_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3160-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3162_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3162-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3166": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3166 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3162_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3162-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3164": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3164 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3165": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3165 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3167": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3167 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3168": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3168 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3170": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3170 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3173_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3173-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3171": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3171 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3176": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3176 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3173_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3173-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3169": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3169 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3174": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3174 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3175": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3175 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3177_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3177-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3177_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3177-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3179": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3179 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3180_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3180-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3184_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3184-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3182": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3182 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3184_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3184-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3180_MIR3180_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3180, hsa-miR-3180-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3183": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3183 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3185": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3185 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3187_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3187-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3186_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3186-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3187_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3187-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3188": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3188 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3189_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3189-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3190_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3190-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3190_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3190-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3189_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3189-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3191_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3191-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3191_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3191-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3192_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3192-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3192_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3192-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3193": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3193 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3194_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3194-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3194_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3194-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3196": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3196 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3198": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3198 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3197": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3197 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR31_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-31-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3199": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3199 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR31_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-31-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3200_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3200-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3200_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3200-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3201": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3201 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3202": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3202 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR320A_3P_MIR320B_MIR320C_MIR320D": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-320a-3p, hsa-miR-320b, hsa-miR-320c, hsa-miR-320d in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR320A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-320a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR320E": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-320e in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR323A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-323a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR323A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-323a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR323B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-323b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR323B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-323b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR324_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-324-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR324_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-324-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR325": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-325 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR328_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-328-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR326": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-326 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR328_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-328-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR329_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-329-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR329_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-329-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR32_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-32-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR32_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-32-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR330_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-330-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR331_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-331-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR330_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-330-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR331_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-331-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR335_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-335-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR335_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-335-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR337_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-337-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR339_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-339-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR33A_5P_MIR33B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-33a-5p, hsa-miR-33b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR338_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-338-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR33A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-33a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR338_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-338-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR340_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-340-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR33B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-33b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR339_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-339-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR340_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-340-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR342_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-342-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR342_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-342-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR345_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-345-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR345_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-345-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR346": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-346 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR34A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-34a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR34A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-34a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR34B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-34b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR34B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-34b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR34C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-34c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3529_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3529-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR34C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-34c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3529_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3529-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3605_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3605-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3606_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3606-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3606_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3606-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3611": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3611 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3609": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3609 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3612": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3612 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3613_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3613-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3614_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3614-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3615": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3615 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3614_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3614-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3616_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3616-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3616_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3616-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3617_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3617-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3618": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3618 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3617_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3617-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3619_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3619-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3619_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3619-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3620_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3620-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR361_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-361-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3622A_3P_MIR3622B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3622a-3p, hsa-miR-3622b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3622A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3622a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3620_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3620-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR361_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-361-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3622B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3622b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR362_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-362-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR363_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-363-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR362_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-362-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3646": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3646 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3652": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3652 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3649": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3649 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR363_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-363-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3654": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3654 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3651": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3651 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3650": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3650 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3657": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3657 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3659": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3659 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR365A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-365a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3658": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3658 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR365B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-365b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR365A_3P_MIR365B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-365a-3p, hsa-miR-365b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3662": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3662 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3663_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3663-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3660": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3660 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3663_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3663-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3661": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3661 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3664_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3664-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3665": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3665 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3664_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3664-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3666": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3666 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3667_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3667-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3667_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3667-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3670": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3670 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3668": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3668 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3671": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3671 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3672": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3672 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3675_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3675-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3677_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3677-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3674": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3674 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3675_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3675-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3677_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3677-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3678_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3678-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3679_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3679-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3678_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3678-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3679_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3679-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR367_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-367-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR367_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-367-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3680_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3680-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3681_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3681-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3680_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3680-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3681_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3681-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3683": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3683 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3682_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3682-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3682_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3682-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3684": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3684 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3685": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3685 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3688_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3688-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3686": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3686 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3688_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3688-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3689A_3P_MIR3689B_3P_MIR3689C": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3689a-3p, hsa-miR-3689b-3p, hsa-miR-3689c in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3689D": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3689d in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3689A_5P_MIR3689B_5P_MIR3689E_MIR3689F": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3689a-5p, hsa-miR-3689b-5p, hsa-miR-3689e, hsa-miR-3689f in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3691_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3691-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3690": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3690 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3691_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3691-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3692_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3692-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3692_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3692-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR370_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-370-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR369_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-369-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR370_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-370-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR371A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-371a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR371B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-371b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3714": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3714 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR371A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-371a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR371B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-371b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR372_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-372-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR373_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-373-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR372_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-372-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR374A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-374a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR373_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-373-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR374B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-374b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR374A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-374a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR374C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-374c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR374B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-374b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR375_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-375-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR374C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-374c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR376A_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-376a-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR376A_3P_MIR376B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-376a-3p, hsa-miR-376b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR376A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-376a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR378A_3P_MIR378C_MIR378D_MIR378I": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-378a-3p, hsa-miR-378c, hsa-miR-378d, hsa-miR-378i in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR377_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-377-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR376B_5P_MIR376C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-376b-5p, hsa-miR-376c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR376C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-376c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR378A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-378a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR377_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-377-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR378B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-378b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR378F": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-378f in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR378E": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-378e in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR378G": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-378g in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR378H": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-378h in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR379_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-379-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR378J": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-378j in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR379_3P_MIR411_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-379-3p, hsa-miR-411-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR380_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-380-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR381_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-381-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR380_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-380-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR382_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-382-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR381_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-381-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR382_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-382-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR384": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-384 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR383_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-383-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR383_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-383-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3908": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3908 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3907": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3907 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3909": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3909 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3911": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3911 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3910": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3910 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3912_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3912-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3912_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3912-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3913_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3913-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3914": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3914 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3913_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3913-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3915": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3915 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3916": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3916 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3919": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3919 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3918": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3918 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3920": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3920 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3921": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3921 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3922_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3922-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3923": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3923 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3922_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3922-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3924": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3924 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3925_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3925-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3925_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3925-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3926": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3926 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3927_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3927-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3927_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3927-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3928_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3928-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3929": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3929 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3928_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3928-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3934_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3934-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3934_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3934-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3935": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3935 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3936": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3936 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3938": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3938 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3940_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3940-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3941": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3941 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3942_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3942-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3943": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3943 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3945": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3945 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3942_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3942-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3972": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3972 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3944_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3944-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3975": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3975 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3960_MIR8072": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3960, hsa-miR-8072 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3974": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3974 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3973": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3973 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3976": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3976 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3978": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3978 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR3977": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-3977 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR409_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-409-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR409_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-409-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR410_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-410-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR412_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-412-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR411_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-411-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR410_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-410-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR412_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-412-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR422A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-422a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR421": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-421 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR423_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-423-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR424_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-424-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR424_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-424-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4252": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4252 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4253": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4253 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4251": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4251 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4257": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4257 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4254": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4254 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4256": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4256 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4258": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4258 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4255": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4255 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR425_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-425-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4259": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4259 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4260": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4260 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4261": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4261 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4263": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4263 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4264": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4264 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4262": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4262 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4265": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4265 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4266": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4266 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4267": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4267 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4268": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4268 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4269": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4269 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4270": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4270 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4271": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4271 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4274": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4274 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4273": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4273 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4275": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4275 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4276": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4276 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4272": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4272 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4277": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4277 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4278": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4278 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4279": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4279 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4281": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4281 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4280": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4280 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4284": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4284 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4286": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4286 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4288": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4288 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4283": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4283 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4287": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4287 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4289": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4289 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4290": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4290 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR429": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-429 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4291": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4291 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4293": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4293 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4292": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4292 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4294": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4294 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4296": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4296 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4295": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4295 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4297": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4297 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4300": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4300 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4298": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4298 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4299": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4299 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4302": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4302 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4301": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4301 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4305": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4305 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4303": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4303 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4307": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4307 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4308": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4308 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4309": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4309 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4306": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4306 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4311": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4311 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4310": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4310 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4312": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4312 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4313": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4313 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4314": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4314 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4315": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4315 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4317": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4317 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4319": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4319 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4316": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4316 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4318": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4318 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4320": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4320 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4322": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4322 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4323": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4323 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR431_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-431-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4321": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4321 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4327": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4327 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4325": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4325 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4328": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4328 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4324": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4324 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4326": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4326 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4329": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4329 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR432_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-432-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4330": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4330 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR432_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-432-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR433_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-433-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR433_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-433-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4421": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4421 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4420": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4420 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4418": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4418 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4422": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4422 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4423_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4423-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4423_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4423-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4424": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4424 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4425": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4425 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4426": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4426 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4427": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4427 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4428": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4428 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4429": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4429 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4430": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4430 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4432": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4432 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4433A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4433a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4433A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4433a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4433B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4433b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4433B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4433b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4434": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4434 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4435": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4435 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4436A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4436a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4436B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4436b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4439": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4439 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4438": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4438 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4440": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4440 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4437": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4437 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4436B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4436b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4442": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4442 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4441": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4441 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4443": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4443 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4446_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4446-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4445_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4445-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4444": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4444 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4445_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4445-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4447": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4447 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4448": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4448 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4451": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4451 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4446_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4446-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4450": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4450 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4452": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4452 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4455": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4455 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4457": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4457 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4453": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4453 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4456": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4456 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4460": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4460 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4458": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4458 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4463": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4463 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4462": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4462 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4464": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4464 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4465": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4465 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4468": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4468 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4469": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4469 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4471": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4471 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4473": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4473 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4470": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4470 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4472": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4472 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4474_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4474-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4474_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4474-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4475": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4475 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4476": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4476 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4477B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4477b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4480": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4480 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4477A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4477a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4478": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4478 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4481": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4481 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4482_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4482-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4482_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4482-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4483": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4483 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR448": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-448 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4484": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4484 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4486": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4486 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4485_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4485-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4487": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4487 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4491": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4491 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4489": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4489 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4490": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4490 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4493": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4493 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4494": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4494 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4495": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4495 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4492": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4492 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4497": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4497 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4496": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4496 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4499": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4499 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR449B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-449b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4498": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4498 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR449A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-449a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR449C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-449c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR449B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-449b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR449C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-449c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4500": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4500 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4502": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4502 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4501": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4501 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4504": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4504 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4503": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4503 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4506": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4506 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4505": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4505 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4507": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4507 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4509": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4509 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR450A_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-450a-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR450B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-450b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR450B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-450b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR450A_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-450a-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4510": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4510 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4512": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4512 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4511": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4511 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4513": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4513 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4514": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4514 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4515": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4515 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4516": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4516 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4517": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4517 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4519": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4519 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4518": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4518 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR451A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-451a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR451B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-451b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4520_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4520-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4520_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4520-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4520_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4520-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4521": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4521 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4524A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4524a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4524B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4524b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4522": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4522 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4524A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4524a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4524B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4524b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4525": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4525 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4527": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4527 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4526": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4526 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4528": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4528 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4529_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4529-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR452_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-452-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4529_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4529-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR452_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-452-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4530": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4530 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4535": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4535 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4534": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4534 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4533": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4533 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4531": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4531 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4536_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4536-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4536_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4536-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4538": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4538 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4537": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4537 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4540": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4540 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4539": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4539 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR454_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-454-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR454_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-454-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR455_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-455-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR455_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-455-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4633_3P_MIR6500_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4633-3p, hsa-miR-6500-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4632_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4632-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4633_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4633-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4635": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4635 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4636": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4636 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4637": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4637 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4638_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4638-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4639_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4639-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4639_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4639-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4640_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4640-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4638_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4638-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4640_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4640-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4641": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4641 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4642": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4642 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4643": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4643 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4645_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4645-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4644": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4644 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4645_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4645-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4646_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4646-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4649_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4649-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4649_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4649-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4646_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4646-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4647_MIR4662B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4647, hsa-miR-4662b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4648": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4648 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4650_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4650-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4650_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4650-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4651": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4651 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4652_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4652-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4652_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4652-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4653_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4653-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4653_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4653-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4656": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4656 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4654": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4654 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4658": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4658 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4659A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4659a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4657": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4657 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4659A_3P_MIR4659B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4659a-3p, hsa-miR-4659b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4659B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4659b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4660": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4660 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR466": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-466 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4661_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4661-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4662A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4662a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4664_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4664-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4661_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4661-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4663": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4663 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4662A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4662a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4665_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4665-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4666A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4666a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4666B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4666b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4666A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4666a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4667_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4667-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4668_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4668-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4668_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4668-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4667_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4667-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4669": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4669 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4670_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4670-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4671_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4671-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4671_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4671-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4673": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4673 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4672": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4672 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4675": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4675 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4676_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4676-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4677_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4677-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4676_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4676-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4678": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4678 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4677_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4677-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4679": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4679 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4681": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4681 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4680_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4680-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4680_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4680-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4682": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4682 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4684_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4684-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4683": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4683 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4684_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4684-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4685_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4685-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4687_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4687-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4686": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4686 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4685_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4685-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4687_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4687-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4688": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4688 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4689": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4689 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4690_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4690-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4690_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4690-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4692": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4692 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4691_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4691-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4693_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4693-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4691_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4691-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4693_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4693-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4694_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4694-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4694_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4694-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4695_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4695-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4695_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4695-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4696": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4696 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4697_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4697-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4697_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4697-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4699_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4699-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4698": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4698 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4699_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4699-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4700_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4700-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4701_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4701-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4700_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4700-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4701_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4701-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4703_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4703-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4703_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4703-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4704_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4704-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4704_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4704-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4705": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4705 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4707_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4707-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4709_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4709-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4708_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4708-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4708_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4708-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4710": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4710 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4711_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4711-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4709_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4709-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4711_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4711-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4712_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4712-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4713_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4713-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4712_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4712-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4714_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4714-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4713_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4713-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4714_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4714-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4715_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4715-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4716_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4716-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4715_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4715-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4717_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4717-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4716_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4716-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4718": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4718 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4717_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4717-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4720_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4720-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4720_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4720-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4719": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4719 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4721": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4721 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4722_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4722-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4722_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4722-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4724_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4724-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4724_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4724-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4723_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4723-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4723_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4723-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4725_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4725-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4725_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4725-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4726_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4726-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4726_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4726-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4727_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4727-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4727_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4727-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4728_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4728-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4730": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4730 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4729": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4729 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4731_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4731-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4728_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4728-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4732_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4732-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4733_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4733-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4731_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4731-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4732_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4732-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4733_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4733-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4735_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4735-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4735_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4735-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4737": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4737 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4736": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4736 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4739": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4739 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4738_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4738-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4740_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4740-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4741": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4741 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4740_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4740-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4742_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4742-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4743_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4743-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4742_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4742-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4744": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4744 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4745_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4745-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4747_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4747-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4749_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4749-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4746_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4746-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4748": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4748 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4749_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4749-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4750_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4750-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4752": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4752 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4753_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4753-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4751": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4751 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4753_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4753-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4755_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4755-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4755_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4755-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4756_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4756-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4756_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4756-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4757_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4757-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4758_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4758-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4759": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4759 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4760_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4760-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4761_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4761-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4760_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4760-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4762_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4762-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4761_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4761-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4762_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4762-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4763_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4763-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4763_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4763-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4764_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4764-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4764_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4764-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4765": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4765 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4766_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4766-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4766_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4766-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4768_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4768-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4768_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4768-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4771": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4771 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4769_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4769-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4772_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4772-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4769_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4769-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4773": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4773 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4772_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4772-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4774_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4774-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4774_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4774-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4776_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4776-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4777_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4777-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4776_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4776-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4777_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4777-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4778_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4778-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4778_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4778-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4779": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4779 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4780": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4780 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4781_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4781-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4781_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4781-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4782_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4782-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4782_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4782-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4784": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4784 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4786_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4786-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4787_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4787-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4786_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4786-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4789_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4789-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4789_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4789-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4790_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4790-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4790_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4790-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4793_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4793-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4791": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4791 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4794": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4794 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4793_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4793-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4795_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4795-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4797_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4797-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4797_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4797-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4796_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4796-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4795_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4795-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4796_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4796-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4799_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4799-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4798_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4798-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4800_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4800-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4799_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4799-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4804_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4804-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4802_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4802-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4802_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4802-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4803": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4803 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4804_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4804-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4801": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4801 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR483_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-483-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR484": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-484 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR483_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-483-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR485_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-485-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR487A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-487a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR486_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-486-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR487A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-487a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR485_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-485-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR486_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-486-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR487B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-487b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR488_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-488-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR487B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-487b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR489_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-489-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR488_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-488-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR490_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-490-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR490_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-490-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR491_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-491-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR491_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-491-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR493_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-493-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR492": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-492 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR494_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-494-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR493_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-493-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR494_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-494-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR495_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-495-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR495_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-495-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR496": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-496 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR498_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-498-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR497_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-497-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR497_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-497-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4999_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4999-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR498_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-498-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR499A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-499a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR499A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-499a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR4999_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-4999-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR499B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-499b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR499B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-499b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5000_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5000-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5001_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5001-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5000_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5000-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5001_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5001-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5002_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5002-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5003_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5003-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5004_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5004-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5002_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5002-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5003_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5003-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5004_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5004-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5006_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5006-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5006_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5006-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5007_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5007-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5007_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5007-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5008_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5008-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5008_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5008-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5009_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5009-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR500A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-500a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR500A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-500a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5009_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5009-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR500B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-500b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR500B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-500b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5010_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5010-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5010_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5010-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR501_3P_MIR502_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-501-3p, hsa-miR-502-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5011_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5011-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR501_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-501-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR503_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-503-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR502_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-502-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR503_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-503-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR504_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-504-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR504_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-504-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR505_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-505-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR506_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-506-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR506_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-506-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR505_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-505-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5087": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5087 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5088_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5088-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5088_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5088-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR507": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-507 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5089_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5089-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5089_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5089-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR508_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-508-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR508_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-508-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5092": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5092 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5093": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5093 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR509_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-509-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5094": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5094 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR509_3_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-509-3-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR509_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-509-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR510_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-510-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5100": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5100 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR510_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-510-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR511_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-511-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR511_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-511-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR512_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-512-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR512_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-512-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR513A_3P_MIR513C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-513a-3p, hsa-miR-513c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR513B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-513b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR513A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-513a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR513B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-513b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR513C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-513c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR514A_3P_MIR514B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-514a-3p, hsa-miR-514b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR514A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-514a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR514B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-514b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR515_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-515-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR515_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-515-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR516A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-516a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR516B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-516b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR516A_3P_MIR516B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-516a-3p, hsa-miR-516b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5186": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5186 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR517A_3P_MIR517B_3P_MIR517C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-517a-3p, hsa-miR-517b-3p, hsa-miR-517c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR517_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-517-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5187_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5187-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5187_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5187-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR518A_5P_MIR527": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-518a-5p, hsa-miR-527 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR518C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-518c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR518A_3P_MIR518B_MIR518C_3P_MIR518D_3P_MIR518F_3P_MIR526A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-518a-3p, hsa-miR-518b, hsa-miR-518c-3p, hsa-miR-518d-3p, hsa-miR-518f-3p, hsa-miR-526a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5189_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5189-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR518E_5P_MIR519A_5P_MIR519B_5P_MIR519C_5P_MIR522_5P_MIR523_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-518e-5p, hsa-miR-519a-5p, hsa-miR-519b-5p, hsa-miR-519c-5p, hsa-miR-522-5p, hsa-miR-523-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5189_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5189-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR518D_5P_MIR518F_5P_MIR520C_5P_MIR526A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-518d-5p, hsa-miR-518f-5p, hsa-miR-520c-5p, hsa-miR-526a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5190": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5190 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5191": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5191 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5192": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5192 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5193": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5193 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5194": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5194 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5196_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5196-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5196_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5196-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5195_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5195-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5197_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5197-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5195_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5195-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5197_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5197-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR519A_2_5P_MIR520B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-519a-2-5p, hsa-miR-520b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR519C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-519c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR519A_3P_MIR519B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-519a-3p, hsa-miR-519b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR519E_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-519e-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR519E_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-519e-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR519D_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-519d-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR519D_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-519d-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520B_3P_MIR520C_3P_MIR520E_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520b-3p, hsa-miR-520c-3p, hsa-miR-520e-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520D_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520d-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520E_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520e-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520F_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520f-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520D_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520d-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520G_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520g-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520F_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520f-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR524_3P_MIR525_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-524-3p, hsa-miR-525-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR520G_3P_MIR520H": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-520g-3p, hsa-miR-520h in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR524_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-524-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR525_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-525-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR522_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-522-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR526B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-526b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR526B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-526b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR532_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-532-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR539_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-539-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR539_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-539-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR541_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-541-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR532_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-532-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR541_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-541-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR542_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-542-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR543": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-543 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR544A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-544a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR545_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-545-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR544B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-544b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR545_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-545-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AC": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ac in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AD_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ad-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AB": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ab in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AA_MIR548AP_3P_MIR548T_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548aa, hsa-miR-548ap-3p, hsa-miR-548t-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AG": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ag in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AE_3P_MIR548AQ_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ae-3p, hsa-miR-548aq-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AD_5P_MIR548AE_5P_MIR548AY_5P_MIR548B_5P_MIR548D_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ad-5p, hsa-miR-548ae-5p, hsa-miR-548ay-5p, hsa-miR-548b-5p, hsa-miR-548d-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AH_3P_MIR548AM_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ah-3p, hsa-miR-548am-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AL": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548al in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AK_MIR548AM_5P_MIR548C_5P_MIR548H_5P_MIR548O_5P_MIR548AU_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ak, hsa-miR-548am-5p, hsa-miR-548c-5p, hsa-miR-548h-5p, hsa-miR-548o-5p, hsa-miR-548au-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AI_MIR570_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ai, hsa-miR-570-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AO_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ao-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AJ_5P_MIR548G_5P_MIR548X_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548aj-5p, hsa-miR-548g-5p, hsa-miR-548x-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AO_5P_MIR548AX": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ao-5p, hsa-miR-548ax in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AN": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548an in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AH_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ah-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AP_5P_MIR548J_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ap-5p, hsa-miR-548j-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AJ_3P_MIR548X_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548aj-3p, hsa-miR-548x-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AQ_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548aq-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AR_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ar-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AR_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ar-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AT_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548at-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AS_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548as-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AS_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548as-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AU_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548au-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AV_5P_MIR548K": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548av-5p, hsa-miR-548k in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AV_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548av-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AT_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548at-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AW": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548aw in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AY_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ay-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AZ_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548az-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548AZ_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548az-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548BA": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548ba in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548BC": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548bc in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548BB_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548bb-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548BB_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548bb-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548D_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548d-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548E_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548e-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548E_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548e-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548F_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548f-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548G_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548g-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548F_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548f-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548H_3P_MIR548Z": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548h-3p, hsa-miR-548z in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548L": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548l in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548I": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548i in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548M": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548m in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548J_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548j-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548O_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548o-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548N": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548n in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548O_5P_MIR548W": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548o-5p, hsa-miR-548w in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548S": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548s in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548Q": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548q in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548T_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548t-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548U": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548u in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548Y": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548y in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR548V": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-548v in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR549A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-549a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR549A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-549a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR550A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-550a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR550A_3_5P_MIR550A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-550a-3-5p, hsa-miR-550a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR551A_MIR551B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-551a, hsa-miR-551b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR550B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-550b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR550B_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-550b-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR551B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-551b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR553": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-553 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR552_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-552-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR552_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-552-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR554": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-554 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR556_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-556-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR555": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-555 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR557": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-557 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR556_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-556-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5571_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5571-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5571_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5571-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5579_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5579-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5572": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5572 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5579_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5579-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR558": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-558 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5580_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5580-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5580_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5580-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5581_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5581-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5581_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5581-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5582_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5582-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5582_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5582-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5583_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5583-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5583_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5583-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5584_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5584-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5584_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5584-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5585_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5585-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5585_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5585-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5588_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5588-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5586_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5586-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5586_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5586-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5588_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5588-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5587_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5587-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5589_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5589-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5589_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5589-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR559": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-559 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5590_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5590-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5590_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5590-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5591_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5591-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5591_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5591-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR563": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-563 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR561_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-561-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR564": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-564 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR562": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-562 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR561_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-561-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR567": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-567 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR568": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-568 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5680": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5680 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5681B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5681b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5682": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5682 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5681A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5681a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5687": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5687 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5683": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5683 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5684": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5684 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5685": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5685 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5688": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5688 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR569": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-569 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5690": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5690 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5689": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5689 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5692B_MIR5692C": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5692b, hsa-miR-5692c in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5693": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5693 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5691_MIR6805_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5691, hsa-miR-6805-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5694": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5694 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5695": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5695 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5697": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5697 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5696": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5696 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5698": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5698 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5699_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5699-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5699_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5699-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5702": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5702 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5700": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5700 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5703": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5703 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5704": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5704 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5701": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5701 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5705": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5705 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5706": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5706 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR570_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-570-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR571": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-571 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR573": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-573 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5739": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5739 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR575": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-575 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR576_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-576-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR574_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-574-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR574_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-574-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR576_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-576-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR577": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-577 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR578": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-578 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR580_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-580-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR5787": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-5787 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR580_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-580-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR579_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-579-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR581": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-581 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR582_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-582-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR582_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-582-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR584_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-584-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR583": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-583 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR584_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-584-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR585_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-585-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR586": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-586 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR589_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-589-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR588": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-588 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR587": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-587 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR589_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-589-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR590_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-590-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR591": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-591 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR592": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-592 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR593_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-593-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR596": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-596 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR593_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-593-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR597_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-597-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR595": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-595 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR598_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-598-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR597_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-597-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR598_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-598-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR600": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-600 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR599": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-599 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR601": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-601 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR603": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-603 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR602": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-602 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR605_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-605-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR604": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-604 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR606": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-606 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR605_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-605-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6069": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6069 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6071": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6071 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR607": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-607 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6072": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6072 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6073": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6073 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6076": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6076 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6079": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6079 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6074": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6074 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR608": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-608 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6077": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6077 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6080": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6080 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6081": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6081 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6082": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6082 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6085": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6085 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6083": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6083 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6086": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6086 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6088": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6088 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6089": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6089 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR610": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-610 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR612": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-612 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR609": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-609 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6090": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6090 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6124": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6124 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6125": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6125 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6126": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6126 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6127": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6127 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6128": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6128 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6129": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6129 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6130": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6130 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6133": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6133 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6131": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6131 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6132": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6132 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR613": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-613 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6134": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6134 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6165": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6165 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR615_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-615-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR615_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-615-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR616_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-616-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR617": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-617 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR616_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-616-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR618": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-618 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR619_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-619-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR620": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-620 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR619_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-619-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR621": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-621 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR622": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-622 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR623": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-623 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR624_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-624-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR624_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-624-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR625_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-625-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR626": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-626 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR625_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-625-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR627_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-627-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR628_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-628-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR628_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-628-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR627_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-627-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR629_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-629-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR629_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-629-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR630": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-630 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR631": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-631 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR633": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-633 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR632": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-632 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR634": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-634 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR635": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-635 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR636": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-636 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR637": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-637 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR640": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-640 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR642A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-642a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR642A_3P_MIR642B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-642a-3p, hsa-miR-642b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR642B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-642b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR644A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-644a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR641": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-641 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR643": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-643 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR645": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-645 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR646": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-646 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR647": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-647 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR649": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-649 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR648": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-648 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6499_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6499-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6500_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6500-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR650": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-650 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6501_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6501-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6501_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6501-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6502_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6502-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6502_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6502-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6503_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6503-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6503_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6503-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6504_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6504-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6504_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6504-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6505_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6505-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6506_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6506-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6505_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6505-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6506_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6506-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6507_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6507-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6507_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6507-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6508_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6508-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6508_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6508-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6509_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6509-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6509_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6509-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6510_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6510-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6511A_3P_MIR6511B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6511a-3p, hsa-miR-6511b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6511B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6511b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6511A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6511a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6512_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6512-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6512_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6512-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6513_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6513-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6513_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6513-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6514_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6514-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6514_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6514-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6515_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6515-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6515_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6515-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6516_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6516-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6516_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6516-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR651_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-651-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR651_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-651-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR652_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-652-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6529_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6529-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR652_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-652-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6529_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6529-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR653_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-653-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR653_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-653-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR654_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-654-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR654_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-654-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR655_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-655-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR655_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-655-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR659_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-659-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR656_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-656-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR656_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-656-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR657": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-657 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR659_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-659-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR661": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-661 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR660_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-660-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR660_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-660-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR662": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-662 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR663A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-663a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR663B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-663b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR664A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-664a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR664B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-664b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR664A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-664a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR664B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-664b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR665": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-665 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR670_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-670-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR668_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-668-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6715A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6715a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR670_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-670-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6715B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6715b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6715B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6715b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6717_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6717-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6718_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6718-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6719_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6719-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6716_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6716-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6720_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6720-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR671_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-671-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6722_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6722-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6721_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6721-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6724_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6724-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6726_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6726-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6729_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6729-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6728_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6728-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6727_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6727-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6730_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6730-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6728_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6728-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6729_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6729-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6731_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6731-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6730_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6730-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6731_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6731-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6732_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6732-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6732_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6732-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6733_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6733-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6734_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6734-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6735_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6735-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6733_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6733-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6734_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6734-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6735_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6735-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6736_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6736-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6736_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6736-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6737_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6737-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6737_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6737-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6738_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6738-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6738_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6738-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6739_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6739-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6740_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6740-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6739_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6739-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6740_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6740-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6741_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6741-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6741_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6741-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6742_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6742-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6742_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6742-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6744_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6744-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6744_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6744-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6743_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6743-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6746_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6746-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6745": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6745 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6747_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6747-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6747_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6747-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6748_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6748-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6748_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6748-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6749_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6749-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6750_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6750-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6751_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6751-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6750_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6750-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6751_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6751-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6753_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6753-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6752_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6752-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6753_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6753-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6754_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6754-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6752_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6752-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6754_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6754-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6755_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6755-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6755_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6755-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6756_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6756-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6757_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6757-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6756_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6756-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6758_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6758-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6757_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6757-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6759_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6759-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6758_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6758-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6759_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6759-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR675_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-675-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6760_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6760-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6760_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6760-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6763_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6763-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6762_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6762-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6761_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6761-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6762_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6762-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6764_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6764-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6765_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6765-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6764_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6764-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6765_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6765-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6766_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6766-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6769A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6769a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6767_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6767-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6768_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6768-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6766_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6766-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6768_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6768-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6769A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6769a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6769B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6769b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6769B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6769b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6771_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6771-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR676_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-676-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6770_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6770-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6773_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6773-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6774_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6774-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR676_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-676-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6770_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6770-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6772_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6772-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6772_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6772-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6773_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6773-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6774_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6774-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6775_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6775-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6776_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6776-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6775_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6775-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6777_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6777-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6776_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6776-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6777_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6777-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6779_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6779-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6778_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6778-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6778_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6778-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6779_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6779-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6780B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6780b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6780A_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6780a-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6780A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6780a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6780B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6780b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6781_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6781-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6782_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6782-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6783_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6783-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6782_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6782-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6784_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6784-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6783_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6783-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6787_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6787-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6787_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6787-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6785_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6785-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6788_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6788-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6789_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6789-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6788_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6788-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6790_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6790-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6790_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6790-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6791_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6791-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6791_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6791-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6792_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6792-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6793_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6793-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6794_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6794-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6794_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6794-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6795_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6795-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6792_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6792-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6793_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6793-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6795_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6795-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6796_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6796-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6796_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6796-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6797_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6797-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6798_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6798-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6797_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6797-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6799_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6799-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6798_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6798-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6800_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6800-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6799_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6799-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6800_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6800-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6801_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6801-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6801_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6801-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6802_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6802-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6802_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6802-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6804_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6804-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6803_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6803-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6804_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6804-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6805_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6805-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6806_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6806-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6806_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6806-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6807_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6807-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6807_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6807-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6808_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6808-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6808_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6808-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6809_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6809-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6809_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6809-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6810_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6810-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6810_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6810-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6811_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6811-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6813_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6813-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6811_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6811-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6812_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6812-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6814_3P_MIR6872_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6814-3p, hsa-miR-6872-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6813_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6813-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6814_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6814-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6815_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6815-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6815_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6815-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6816_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6816-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6816_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6816-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6817_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6817-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6818_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6818-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6817_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6817-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6818_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6818-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6819_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6819-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6820_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6820-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6819_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6819-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6820_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6820-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6822_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6822-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6822_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6822-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6821_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6821-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6823_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6823-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6823_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6823-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6824_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6824-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6824_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6824-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6825_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6825-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6826_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6826-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6826_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6826-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6827_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6827-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6828_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6828-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6827_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6827-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6829_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6829-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6828_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6828-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6829_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6829-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6830_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6830-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6831_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6831-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6830_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6830-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6831_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6831-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6832_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6832-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6832_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6832-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6833_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6833-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6834_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6834-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6833_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6833-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6834_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6834-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6835_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6835-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6835_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6835-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6836_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6836-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6837_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6837-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6836_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6836-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6838_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6838-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6837_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6837-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6838_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6838-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6839_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6839-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6839_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6839-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6841_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6841-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6840_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6840-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6841_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6841-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6842_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6842-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6842_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6842-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6843_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6843-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6844": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6844 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6845_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6845-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6845_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6845-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6846_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6846-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6846_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6846-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6847_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6847-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6847_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6847-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6848_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6848-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6849_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6849-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6849_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6849-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6848_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6848-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6851_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6851-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6852_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6852-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6851_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6851-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6852_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6852-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6853_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6853-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6853_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6853-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6854_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6854-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6855_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6855-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6856_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6856-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6854_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6854-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6855_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6855-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6857_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6857-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6856_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6856-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6857_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6857-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6858_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6858-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6858_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6858-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6859_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6859-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6859_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6859-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6860": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6860 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6861_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6861-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6862_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6862-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6861_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6861-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6862_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6862-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6863": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6863 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6865_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6865-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6864_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6864-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6864_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6864-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6865_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6865-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6866_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6866-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6866_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6866-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6867_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6867-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6869_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6869-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6868_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6868-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6868_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6868-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6867_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6867-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6870_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6870-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6870_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6870-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6871_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6871-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6871_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6871-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6872_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6872-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6873_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6873-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6873_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6873-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6874_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6874-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6874_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6874-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6875_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6875-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6875_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6875-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6877_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6877-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6876_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6876-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6876_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6876-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6878_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6878-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6879_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6879-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6879_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6879-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6878_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6878-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6882_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6882-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6881_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6881-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6881_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6881-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6880_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6880-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6883_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6883-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6882_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6882-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6884_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6884-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6883_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6883-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6884_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6884-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6885_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6885-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6885_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6885-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6886_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6886-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6886_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6886-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6888_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6888-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6887_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6887-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6887_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6887-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6888_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6888-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6889_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6889-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6889_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6889-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6890_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6890-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6890_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6890-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6891_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6891-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6891_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6891-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6892_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6892-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6892_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6892-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6893_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6893-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6894_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6894-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6894_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6894-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6893_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6893-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6895_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6895-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR6895_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-6895-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR708_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-708-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR708_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-708-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7107_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7107-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7106_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7106-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7108_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7108-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7106_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7106-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7108_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7108-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR711": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-711 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7109_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7109-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7109_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7109-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7110_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7110-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7110_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7110-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7111_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7111-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7111_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7111-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7112_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7112-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7112_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7112-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7113_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7113-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7114_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7114-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7114_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7114-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7150": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7150 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7113_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7113-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7151_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7151-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7151_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7151-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7153_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7153-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7152_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7152-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7153_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7153-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7152_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7152-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7154_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7154-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7155_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7155-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7155_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7155-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7154_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7154-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7156_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7156-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7156_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7156-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7158_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7158-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7157_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7157-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7158_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7158-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7157_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7157-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7160_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7160-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7159_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7159-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7159_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7159-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7160_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7160-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7161_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7161-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7161_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7161-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7162_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7162-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7162_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7162-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR744_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-744-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR744_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-744-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7515": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7515 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR758_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-758-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR758_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-758-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR759": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-759 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR761": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-761 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR760": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-760 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR764": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-764 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR762": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-762 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR766_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-766-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR765": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-765 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR767_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-767-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR766_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-766-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR767_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-767-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR769_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-769-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR769_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-769-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7702": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7702 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7706": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7706 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7703": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7703 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7704": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7704 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7843_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7843-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7705": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7705 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR770_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-770-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7843_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7843-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7844_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7844-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7847_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7847-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7845_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7845-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7848_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7848-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7850_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7850-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7849_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7849-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7852_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7852-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7855_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7855-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7973": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7973 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7851_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7851-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7856_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7856-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7854_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7854-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7853_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7853-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7974": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7974 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7975": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7975 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7976": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7976 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7977": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7977 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7978": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7978 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR802": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-802 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7_1_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7-1-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8053": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8053 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8052": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8052 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR7_2_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-7-2-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8056": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8056 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8055": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8055 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8054": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8054 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8057": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8057 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8058": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8058 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8059": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8059 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8060": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8060 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8062": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8062 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8064": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8064 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8061": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8061 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8063": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8063 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8068": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8068 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8065": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8065 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8069": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8069 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8066": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8066 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8067": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8067 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8071": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8071 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8070": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8070 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8074": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8074 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8073": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8073 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8075": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8075 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8079": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8079 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8078": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8078 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8077": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8077 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8076": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8076 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8080": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8080 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8081": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8081 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8082": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8082 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8083": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8083 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8084": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8084 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8085": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8085 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8087": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8087 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8086": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8086 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8088": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8088 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8089": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8089 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR873_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-873-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR8485": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-8485 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR873_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-873-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR874_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-874-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR874_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-874-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR875_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-875-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR876_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-876-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR875_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-875-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR877_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-877-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR876_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-876-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR877_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-877-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR885_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-885-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR887_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-887-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR885_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-885-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR887_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-887-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR888_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-888-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR888_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-888-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR891A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-891a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR890": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-890 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR889_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-889-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR889_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-889-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR891B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-891b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR892B": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-892b in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR892A": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-892a in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR892C_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-892c-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR920": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-920 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR892C_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-892c-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR924": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-924 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR921": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-921 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR922": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-922 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR92A_1_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-92a-1-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR92A_2_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-92a-2-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR92A_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-92a-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR92B_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-92b-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR92B_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-92b-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR933": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-933 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR934": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-934 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR935": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-935 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR938": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-938 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR936": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-936 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR937_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-937-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR939_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-939-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR93_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-93-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR939_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-939-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR940": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-940 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR942_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-942-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR943": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-943 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR942_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-942-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR95_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-95-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR93_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-93-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR944": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-944 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9500": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9500 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR96_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-96-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR95_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-95-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9718": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9718 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR96_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-96-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9899": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9899 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9851_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9851-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9851_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9851-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9898": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9898 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR98_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-98-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR98_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-98-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9900": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9900 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9902": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9902 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9903": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9903 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9983_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9983-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "AAACCAC_MIR140": "Genes having at least one occurence of the motif AAACCAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-140 (v7.1 miRBase).", "MIR9_3P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9-3p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9985": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9985 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "AAAGGAT_MIR501": "Genes having at least one occurence of the motif AAAGGAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-501 (v7.1 miRBase).", "MIR9986": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9986 in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "MIR9_5P": "Genes predicted to be targets of miRBase v22 microRNA hsa-miR-9-5p in miRDB v6.0 with MirTarget v4 prediction scores > 80 (high confidence targets).", "AAAGACA_MIR511": "Genes having at least one occurence of the motif AAAGACA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-511 (v7.1 miRBase).", "AAAGGGA_MIR204_MIR211": "Genes having at least one occurence of the motif AAAGGGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-204 and hsa-miR-211 (v7.1 miRBase).", "AACGGTT_MIR451": "Genes having at least one occurence of the motif AACGGTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-451 (v7.1 miRBase).", "AACATTC_MIR4093P": "Genes having at least one occurence of the motif AACATTC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-409-3p (v7.1 miRBase).", "AACTGAC_MIR223": "Genes having at least one occurence of the motif AACTGAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-223 (v7.1 miRBase).", "AACTGGA_MIR145": "Genes having at least one occurence of the motif AACTGGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-145 (v7.1 miRBase).", "AAGCACT_MIR520F": "Genes having at least one occurence of the motif AAGCACT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-520f (v7.1 miRBase).", "AAGCAAT_MIR137": "Genes having at least one occurence of the motif AAGCAAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-137 (v7.1 miRBase).", "AAGGGAT_MIR188": "Genes having at least one occurence of the motif AAGGGAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-188 (v7.1 miRBase).", "AAGTCCA_MIR422B_MIR422A": "Genes having at least one occurence of the motif AAGTCCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-422b and hsa-miR-422a (v7.1 miRBase).", "AAGCACA_MIR218": "Genes having at least one occurence of the motif AAGCACA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-218 (v7.1 miRBase).", "AATGGAG_MIR136": "Genes having at least one occurence of the motif AATGGAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-136 (v7.1 miRBase).", "AAGCCAT_MIR135A_MIR135B": "Genes having at least one occurence of the motif AAGCCAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-135a and hsa-miR-135b (v7.1 miRBase).", "AATGTGA_MIR23A_MIR23B": "Genes having at least one occurence of the motif AATGTGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-23a and hsa-miR-23b (v7.1 miRBase).", "ACAACTT_MIR382": "Genes having at least one occurence of the motif ACAACTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-382 (v7.1 miRBase).", "ACAACCT_MIR453": "Genes having at least one occurence of the motif ACAACCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-453 (v7.1 miRBase).", "ACACTAC_MIR1423P": "Genes having at least one occurence of the motif ACACTAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-142-3p (v7.1 miRBase).", "ACAGGGT_MIR10A_MIR10B": "Genes having at least one occurence of the motif ACAGGGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-10a and hsa-miR-10b (v7.1 miRBase).", "ACACTCC_MIR122A": "Genes having at least one occurence of the motif ACACTCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-122a (v7.1 miRBase).", "ACATATC_MIR190": "Genes having at least one occurence of the motif ACATATC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-190 (v7.1 miRBase).", "ACACTGG_MIR199A_MIR199B": "Genes having at least one occurence of the motif ACACTGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-199a and hsa-miR-199b (v7.1 miRBase).", "ACATTCC_MIR1_MIR206": "Genes having at least one occurence of the motif ACATTCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-1 and hsa-miR-206 (v7.1 miRBase).", "ACCAATC_MIR509": "Genes having at least one occurence of the motif ACCAATC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-509 (v7.1 miRBase).", "ACCGAGC_MIR423": "Genes having at least one occurence of the motif ACCGAGC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-423 (v7.1 miRBase).", "ACCAAAG_MIR9": "Genes having at least one occurence of the motif ACCAAAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-9 (v7.1 miRBase).", "ACGCACA_MIR210": "Genes having at least one occurence of the motif ACGCACA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-210 (v7.1 miRBase).", "ACCATTT_MIR522": "Genes having at least one occurence of the motif ACCATTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-522 (v7.1 miRBase).", "ACTACCT_MIR196A_MIR196B": "Genes having at least one occurence of the motif ACTACCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-196a and hsa-miR-196b (v7.1 miRBase).", "ACTGCAG_MIR173P": "Genes having at least one occurence of the motif ACTGCAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-17-3p (v7.1 miRBase).", "ACTGAAA_MIR30A3P_MIR30E3P": "Genes having at least one occurence of the motif ACTGAAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-30a-3p and hsa-miR-30e-3p (v7.1 miRBase).", "ACTGTAG_MIR139": "Genes having at least one occurence of the motif ACTGTAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-139 (v7.1 miRBase).", "ACTGCCT_MIR34B": "Genes having at least one occurence of the motif ACTGCCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-34b (v7.1 miRBase).", "ACTTTAT_MIR1425P": "Genes having at least one occurence of the motif ACTTTAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-142-5p (v7.1 miRBase).", "AGCATTA_MIR155": "Genes having at least one occurence of the motif AGCATTA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-155 (v7.1 miRBase).", "AGCGCAG_MIR191": "Genes having at least one occurence of the motif AGCGCAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-191* (v7.1 miRBase).", "AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D": "Genes having at least one occurence of the motif AGCACTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-93, hsa-miR-302a, hsa-miR-302b, hsa-miR-302c, hsa-miR-302d, hsa-miR-372, hsa-miR-373, hsa-miR-520e, hsa-miR-520a, hsa-miR-526b*, hsa-miR-520b, hsa-miR-520c and hsa-miR-520d (v7.1 miRBase).", "AGCGCTT_MIR518F_MIR518E_MIR518A": "Genes having at least one occurence of the motif AGCGCTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-518f, hsa-miR-518e and hsa-miR-518a (v7.1 miRBase).", "ACTGTGA_MIR27A_MIR27B": "Genes having at least one occurence of the motif ACTGTGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-27a and hsa-miR-27b (v7.1 miRBase).", "AGCTCCT_MIR28": "Genes having at least one occurence of the motif AGCTCCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-28 (v7.1 miRBase).", "AGGAAGC_MIR5163P": "Genes having at least one occurence of the motif AGGAAGC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-516-3p (v7.1 miRBase).", "AGGCACT_MIR5153P": "Genes having at least one occurence of the motif AGGCACT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-515-3p (v7.1 miRBase).", "AGGAGTG_MIR483": "Genes having at least one occurence of the motif AGGAGTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-483 (v7.1 miRBase).", "AGGGCAG_MIR18A": "Genes having at least one occurence of the motif AGGGCAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-18a* (v7.1 miRBase).", "AGGGCCA_MIR328": "Genes having at least one occurence of the motif AGGGCCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-328 (v7.1 miRBase).", "AGTCTAG_MIR151": "Genes having at least one occurence of the motif AGTCTAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-151 (v7.1 miRBase).", "AGGTGCA_MIR500": "Genes having at least one occurence of the motif AGGTGCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-500 (v7.1 miRBase).", "AGTCAGC_MIR345": "Genes having at least one occurence of the motif AGTCAGC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-345 (v7.1 miRBase).", "AGTCTTA_MIR499": "Genes having at least one occurence of the motif AGTCTTA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-499 (v7.1 miRBase).", "AGTGCGT_MIR521": "Genes having at least one occurence of the motif AGTGCGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-521 (v7.1 miRBase).", "AGTTCTC_MIR146A_MIR146B": "Genes having at least one occurence of the motif AGTTCTC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-146a and hsa-miR-146b (v7.1 miRBase).", "ATAAGCT_MIR21": "Genes having at least one occurence of the motif ATAAGCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-21 (v7.1 miRBase).", "ATAACCT_MIR154": "Genes having at least one occurence of the motif ATAACCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-154 (v7.1 miRBase).", "ATACTGT_MIR144": "Genes having at least one occurence of the motif ATACTGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-144 (v7.1 miRBase).", "ATACCTC_MIR202": "Genes having at least one occurence of the motif ATACCTC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-202 (v7.1 miRBase).", "ATAGGAA_MIR202": "Genes having at least one occurence of the motif ATAGGAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-202* (v7.1 miRBase).", "ATATGCA_MIR448": "Genes having at least one occurence of the motif ATATGCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-448 (v7.1 miRBase).", "ATCTTGC_MIR31": "Genes having at least one occurence of the motif ATCTTGC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-31 (v7.1 miRBase).", "ATCATGA_MIR433": "Genes having at least one occurence of the motif ATCATGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-433 (v7.1 miRBase).", "ATGCACG_MIR517B": "Genes having at least one occurence of the motif ATGCACG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-517b (v7.1 miRBase).", "ATGAAGG_MIR205": "Genes having at least one occurence of the motif ATGAAGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-205 (v7.1 miRBase).", "ATGCAGT_MIR217": "Genes having at least one occurence of the motif ATGCAGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-217 (v7.1 miRBase).", "ATGCTGC_MIR103_MIR107": "Genes having at least one occurence of the motif ATGCTGC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-103 and hsa-miR-107 (v7.1 miRBase).", "ATGCTGG_MIR338": "Genes having at least one occurence of the motif ATGCTGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-338 (v7.1 miRBase).", "ATGTAGC_MIR221_MIR222": "Genes having at least one occurence of the motif ATGTAGC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-221 and hsa-miR-222 (v7.1 miRBase).", "ATGTACA_MIR493": "Genes having at least one occurence of the motif ATGTACA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-493 (v7.1 miRBase).", "ATGTCAC_MIR489": "Genes having at least one occurence of the motif ATGTCAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-489 (v7.1 miRBase).", "ATGTTAA_MIR302C": "Genes having at least one occurence of the motif ATGTTAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-302c* (v7.1 miRBase).", "ATTACAT_MIR3803P": "Genes having at least one occurence of the motif ATTACAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-380-3p (v7.1 miRBase).", "ATGTTTC_MIR494": "Genes having at least one occurence of the motif ATGTTTC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-494 (v7.1 miRBase).", "CAAGGAT_MIR362": "Genes having at least one occurence of the motif CAAGGAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-362 (v7.1 miRBase).", "ATTCTTT_MIR186": "Genes having at least one occurence of the motif ATTCTTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-186 (v7.1 miRBase).", "CAATGCA_MIR33": "Genes having at least one occurence of the motif CAATGCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-33 (v7.1 miRBase).", "CACGTTT_MIR302A": "Genes having at least one occurence of the motif CACGTTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-302a* (v7.1 miRBase).", "CACCAGC_MIR138": "Genes having at least one occurence of the motif CACCAGC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-138 (v7.1 miRBase).", "CACTGCC_MIR34A_MIR34C_MIR449": "Genes having at least one occurence of the motif CACTGCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-34a, hsa-miR-34c and hsa-miR-449 (v7.1 miRBase).", "CAGCACT_MIR5123P": "Genes having at least one occurence of the motif CAGCACT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-512-3p (v7.1 miRBase).", "CACTGTG_MIR128A_MIR128B": "Genes having at least one occurence of the motif CACTGTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-128a and hsa-miR-128b (v7.1 miRBase).", "CAGCCTC_MIR4855P": "Genes having at least one occurence of the motif CAGCCTC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-485-5p (v7.1 miRBase).", "CAGCAGG_MIR370": "Genes having at least one occurence of the motif CAGCAGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-370 (v7.1 miRBase).", "CACTTTG_MIR520G_MIR520H": "Genes having at least one occurence of the motif CACTTTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-520g and hsa-miR-520h (v7.1 miRBase).", "CAGGGTC_MIR504": "Genes having at least one occurence of the motif CAGGGTC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-504 (v7.1 miRBase).", "CAGCTTT_MIR320": "Genes having at least one occurence of the motif CAGCTTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-320 (v7.1 miRBase).", "CAGGTCC_MIR492": "Genes having at least one occurence of the motif CAGGTCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-492 (v7.1 miRBase).", "CAGTCAC_MIR134": "Genes having at least one occurence of the motif CAGTCAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-134 (v7.1 miRBase).", "CAGTATT_MIR200B_MIR200C_MIR429": "Genes having at least one occurence of the motif CAGTATT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-200b, hsa-miR-200c and hsa-miR-429 (v7.1 miRBase).", "CCAGGGG_MIR331": "Genes having at least one occurence of the motif CCAGGGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-331 (v7.1 miRBase).", "CATGTAA_MIR496": "Genes having at least one occurence of the motif CATGTAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-496 (v7.1 miRBase).", "CAGTGTT_MIR141_MIR200A": "Genes having at least one occurence of the motif CAGTGTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-141 and hsa-miR-200a (v7.1 miRBase).", "CCACACA_MIR147": "Genes having at least one occurence of the motif CCACACA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-147 (v7.1 miRBase).", "CATTTCA_MIR203": "Genes having at least one occurence of the motif CATTTCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-203 (v7.1 miRBase).", "CCCACAT_MIR2993P": "Genes having at least one occurence of the motif CCCACAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-299-3p (v7.1 miRBase).", "CCATCCA_MIR432": "Genes having at least one occurence of the motif CCATCCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-432* (v7.1 miRBase).", "CCAGGTT_MIR490": "Genes having at least one occurence of the motif CCAGGTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-490 (v7.1 miRBase).", "CCCAGAG_MIR326": "Genes having at least one occurence of the motif CCCAGAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-326 (v7.1 miRBase).", "CCTGAGT_MIR510": "Genes having at least one occurence of the motif CCTGAGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-510 (v7.1 miRBase).", "CGCAAAA_MIR450": "Genes having at least one occurence of the motif CGCAAAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-450 (v7.1 miRBase).", "CCTGCTG_MIR214": "Genes having at least one occurence of the motif CCTGCTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-214 (v7.1 miRBase).", "CGCTGCT_MIR503": "Genes having at least one occurence of the motif CGCTGCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-503 (v7.1 miRBase).", "CCTGTGA_MIR513": "Genes having at least one occurence of the motif CCTGTGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-513 (v7.1 miRBase).", "CGGTGTG_MIR220": "Genes having at least one occurence of the motif CGGTGTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-220 (v7.1 miRBase).", "CGTCTTA_MIR208": "Genes having at least one occurence of the motif CGTCTTA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-208 (v7.1 miRBase).", "CTACTAG_MIR325": "Genes having at least one occurence of the motif CTACTAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-325 (v7.1 miRBase).", "CTAGGAA_MIR384": "Genes having at least one occurence of the motif CTAGGAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-384 (v7.1 miRBase).", "CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I": "Genes having at least one occurence of the motif CTACCTC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f, hsa-miR-98, hsa-let-7g and hsa-let-7i (v7.1 miRBase).", "CTACTGT_MIR199A": "Genes having at least one occurence of the motif CTACTGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-199a* (v7.1 miRBase).", "CTATGCA_MIR153": "Genes having at least one occurence of the motif CTATGCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-153 (v7.1 miRBase).", "CTCAAGA_MIR526B": "Genes having at least one occurence of the motif CTCAAGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-526b (v7.1 miRBase).", "CTCTAGA_MIR526C_MIR518F_MIR526A": "Genes having at least one occurence of the motif CTCTAGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-526c, hsa-miR-518f* and hsa-miR-526a (v7.1 miRBase).", "CTCTATG_MIR368": "Genes having at least one occurence of the motif CTCTATG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-368 (v7.1 miRBase).", "CTCCAAG_MIR432": "Genes having at least one occurence of the motif CTCCAAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-432 (v7.1 miRBase).", "CTCTGGA_MIR520A_MIR525": "Genes having at least one occurence of the motif CTCTGGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-520a* and hsa-miR-525 (v7.1 miRBase).", "CTGTTAC_MIR194": "Genes having at least one occurence of the motif CTGTTAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-194 (v7.1 miRBase).", "CTCAGGG_MIR125B_MIR125A": "Genes having at least one occurence of the motif CTCAGGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-125b and hsa-miR-125a (v7.1 miRBase).", "CTGAGCC_MIR24": "Genes having at least one occurence of the motif CTGAGCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-24 (v7.1 miRBase).", "CTTGTAT_MIR381": "Genes having at least one occurence of the motif CTTGTAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-381 (v7.1 miRBase).", "CTTTGCA_MIR527": "Genes having at least one occurence of the motif CTTTGCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-527 (v7.1 miRBase).", "GACAGGG_MIR339": "Genes having at least one occurence of the motif GACAGGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-339 (v7.1 miRBase).", "GACTGTT_MIR212_MIR132": "Genes having at least one occurence of the motif GACTGTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-212 and hsa-miR-132 (v7.1 miRBase).", "GACAATC_MIR219": "Genes having at least one occurence of the motif GACAATC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-219 (v7.1 miRBase).", "GAGCCAG_MIR149": "Genes having at least one occurence of the motif GAGCCAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-149 (v7.1 miRBase).", "GAGACTG_MIR452": "Genes having at least one occurence of the motif GAGACTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-452* (v7.1 miRBase).", "GAGCCTG_MIR484": "Genes having at least one occurence of the motif GAGCCTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-484 (v7.1 miRBase).", "CTTTGTA_MIR524": "Genes having at least one occurence of the motif CTTTGTA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-524* (v7.1 miRBase).", "GAGCTGG_MIR337": "Genes having at least one occurence of the motif GAGCTGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-337 (v7.1 miRBase).", "GCAAGAC_MIR431": "Genes having at least one occurence of the motif GCAAGAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-431 (v7.1 miRBase).", "GCAAAAA_MIR129": "Genes having at least one occurence of the motif GCAAAAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-129 (v7.1 miRBase).", "GCAAGGA_MIR502": "Genes having at least one occurence of the motif GCAAGGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-502 (v7.1 miRBase).", "GCACCTT_MIR18A_MIR18B": "Genes having at least one occurence of the motif GCACCTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-18a and hsa-miR-18b (v7.1 miRBase).", "GCGCCTT_MIR525_MIR524": "Genes having at least one occurence of the motif GCGCCTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-525* and hsa-miR-524 (v7.1 miRBase).", "GCGCTTT_MIR518B_MIR518C_MIR518D": "Genes having at least one occurence of the motif GCGCTTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-518b, hsa-miR-518c and hsa-miR-518d (v7.1 miRBase).", "GCATTTG_MIR105": "Genes having at least one occurence of the motif GCATTTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-105 (v7.1 miRBase).", "GCTGAGT_MIR5125P": "Genes having at least one occurence of the motif GCTGAGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-512-5p (v7.1 miRBase).", "GGATCCG_MIR127": "Genes having at least one occurence of the motif GGATCCG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-127 (v7.1 miRBase).", "GCTCTTG_MIR335": "Genes having at least one occurence of the motif GCTCTTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-335 (v7.1 miRBase).", "GCTTGAA_MIR498": "Genes having at least one occurence of the motif GCTTGAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-498 (v7.1 miRBase).", "GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D": "Genes having at least one occurence of the motif GCACTTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-17-5p, hsa-miR-20a, hsa-miR-106a, hsa-miR-106b, hsa-miR-20b and hsa-miR-519d (v7.1 miRBase).", "GGCACTT_MIR519E": "Genes having at least one occurence of the motif GGCACTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-519e (v7.1 miRBase).", "GGCACAT_MIR455": "Genes having at least one occurence of the motif GGCACAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-455 (v7.1 miRBase).", "GGCAGAC_MIR346": "Genes having at least one occurence of the motif GGCAGAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-346 (v7.1 miRBase).", "GGCAGTG_MIR3243P": "Genes having at least one occurence of the motif GGCAGTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-324-3p (v7.1 miRBase).", "GGCGGCA_MIR371": "Genes having at least one occurence of the motif GGCGGCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-371 (v7.1 miRBase).", "GGCAGCT_MIR22": "Genes having at least one occurence of the motif GGCAGCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-22 (v7.1 miRBase).", "GGCCAGT_MIR193A_MIR193B": "Genes having at least one occurence of the motif GGCCAGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-193a and hsa-miR-193b (v7.1 miRBase).", "GGGATGC_MIR3245P": "Genes having at least one occurence of the motif GGGATGC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-324-5p (v7.1 miRBase).", "GGGGCCC_MIR296": "Genes having at least one occurence of the motif GGGGCCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-296 (v7.1 miRBase).", "GGTAACC_MIR4095P": "Genes having at least one occurence of the motif GGTAACC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-409-5p (v7.1 miRBase).", "GGGCATT_MIR365": "Genes having at least one occurence of the motif GGGCATT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-365 (v7.1 miRBase).", "GGGACCA_MIR133A_MIR133B": "Genes having at least one occurence of the motif GGGACCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-133a and hsa-miR-133b (v7.1 miRBase).", "GGTGAAG_MIR412": "Genes having at least one occurence of the motif GGTGAAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-412 (v7.1 miRBase).", "GGTGTGT_MIR329": "Genes having at least one occurence of the motif GGTGTGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-329 (v7.1 miRBase).", "GTAAGAT_MIR200A": "Genes having at least one occurence of the motif GTAAGAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-200a* (v7.1 miRBase).", "GTAAACC_MIR2995P": "Genes having at least one occurence of the motif GTAAACC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-299-5p (v7.1 miRBase).", "GTACAGG_MIR486": "Genes having at least one occurence of the motif GTACAGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-486 (v7.1 miRBase).", "GTACTGT_MIR101": "Genes having at least one occurence of the motif GTACTGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-101 (v7.1 miRBase).", "GTAGGCA_MIR189": "Genes having at least one occurence of the motif GTAGGCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-189 (v7.1 miRBase).", "GTCAACC_MIR3805P": "Genes having at least one occurence of the motif GTCAACC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-380-5p (v7.1 miRBase).", "GTCGATC_MIR3695P": "Genes having at least one occurence of the motif GTCGATC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-369-5p (v7.1 miRBase).", "GTATGAT_MIR154_MIR487": "Genes having at least one occurence of the motif GTATGAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-154* and hsa-miR-487 (v7.1 miRBase).", "GTCAGGA_MIR378": "Genes having at least one occurence of the motif GTCAGGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-378 (v7.1 miRBase).", "GTATTAT_MIR3693P": "Genes having at least one occurence of the motif GTATTAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-369-3p (v7.1 miRBase).", "GTCTACC_MIR379": "Genes having at least one occurence of the motif GTCTACC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-379 (v7.1 miRBase).", "GTCTTCC_MIR7": "Genes having at least one occurence of the motif GTCTTCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-7 (v7.1 miRBase).", "GTGCAAA_MIR507": "Genes having at least one occurence of the motif GTGCAAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-507 (v7.1 miRBase).", "GTGACTT_MIR224": "Genes having at least one occurence of the motif GTGACTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-224 (v7.1 miRBase).", "GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367": "Genes having at least one occurence of the motif GTGCAAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-25, hsa-miR-32, hsa-miR-92, hsa-miR-363 and hsa-miR-367 (v7.1 miRBase).", "GTGGTGA_MIR197": "Genes having at least one occurence of the motif GTGGTGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-197 (v7.1 miRBase).", "GTGTCAA_MIR514": "Genes having at least one occurence of the motif GTGTCAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-514 (v7.1 miRBase).", "GTGCCAA_MIR96": "Genes having at least one occurence of the motif GTGCCAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-96 (v7.1 miRBase).", "GTGTGAG_MIR342": "Genes having at least one occurence of the motif GTGTGAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-342 (v7.1 miRBase).", "GTGCCAT_MIR183": "Genes having at least one occurence of the motif GTGCCAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-183 (v7.1 miRBase).", "GTGTTGA_MIR505": "Genes having at least one occurence of the motif GTGTTGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-505 (v7.1 miRBase).", "GTGCCTT_MIR506": "Genes having at least one occurence of the motif GTGCCTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-506 (v7.1 miRBase).", "GTTAAAG_MIR302B": "Genes having at least one occurence of the motif GTTAAAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-302b* (v7.1 miRBase).", "GTTATAT_MIR410": "Genes having at least one occurence of the motif GTTATAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-410 (v7.1 miRBase).", "GTTTGTT_MIR495": "Genes having at least one occurence of the motif GTTTGTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-495 (v7.1 miRBase).", "TACAATC_MIR508": "Genes having at least one occurence of the motif TACAATC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-508 (v7.1 miRBase).", "TACGGGT_MIR99A_MIR100_MIR99B": "Genes having at least one occurence of the motif TACGGGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-99a, hsa-miR-100 and hsa-miR-99b (v7.1 miRBase).", "TACTTGA_MIR26A_MIR26B": "Genes having at least one occurence of the motif TACTTGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-26a and hsa-miR-26b (v7.1 miRBase).", "TAATGTG_MIR323": "Genes having at least one occurence of the motif TAATGTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-323 (v7.1 miRBase).", "TAATAAT_MIR126": "Genes having at least one occurence of the motif TAATAAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-126* (v7.1 miRBase).", "TAGAACC_MIR182": "Genes having at least one occurence of the motif TAGAACC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-182* (v7.1 miRBase).", "TATCTGG_MIR488": "Genes having at least one occurence of the motif TATCTGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-488 (v7.1 miRBase).", "TAGGTCA_MIR192_MIR215": "Genes having at least one occurence of the motif TAGGTCA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-192 and hsa-miR-215 (v7.1 miRBase).", "TAGCTTT_MIR9": "Genes having at least one occurence of the motif TAGCTTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-9* (v7.1 miRBase).", "TCATCTC_MIR143": "Genes having at least one occurence of the motif TCATCTC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-143 (v7.1 miRBase).", "TCCGTCC_MIR184": "Genes having at least one occurence of the motif TCCGTCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-184 (v7.1 miRBase).", "TCCAGAT_MIR5165P": "Genes having at least one occurence of the motif TCCAGAT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-516-5p (v7.1 miRBase).", "TCGATGG_MIR213": "Genes having at least one occurence of the motif TCGATGG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-213 (v7.1 miRBase).", "TCCCCAC_MIR491": "Genes having at least one occurence of the motif TCCCCAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-491 (v7.1 miRBase).", "TCCAGAG_MIR518C": "Genes having at least one occurence of the motif TCCAGAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-518c* (v7.1 miRBase).", "TATTATA_MIR374": "Genes having at least one occurence of the motif TATTATA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-374 (v7.1 miRBase).", "TCTAGAG_MIR517": "Genes having at least one occurence of the motif TCTAGAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-517* (v7.1 miRBase).", "TCTATGA_MIR376A_MIR376B": "Genes having at least one occurence of the motif TCTATGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-376a and hsa-miR-376b (v7.1 miRBase).", "TCTCTCC_MIR185": "Genes having at least one occurence of the motif TCTCTCC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-185 (v7.1 miRBase).", "TCTGATC_MIR383": "Genes having at least one occurence of the motif TCTGATC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-383 (v7.1 miRBase).", "TCTGATA_MIR361": "Genes having at least one occurence of the motif TCTGATA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-361 (v7.1 miRBase).", "TGCACGA_MIR517A_MIR517C": "Genes having at least one occurence of the motif TGCACGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-517a and hsa-miR-517c (v7.1 miRBase).", "TGAGATT_MIR216": "Genes having at least one occurence of the motif TGAGATT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-216 (v7.1 miRBase).", "TGCAAAC_MIR452": "Genes having at least one occurence of the motif TGCAAAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-452 (v7.1 miRBase).", "TCTGGAC_MIR198": "Genes having at least one occurence of the motif TCTGGAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-198 (v7.1 miRBase).", "TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D": "Genes having at least one occurence of the motif TGAATGT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-181a, hsa-miR-181b, hsa-miR-181c and hsa-miR-181d (v7.1 miRBase).", "TGCACTG_MIR148A_MIR152_MIR148B": "Genes having at least one occurence of the motif TGCACTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-148a, hsa-miR-152 and hsa-miR-148b (v7.1 miRBase).", "TGCCTTA_MIR124A": "Genes having at least one occurence of the motif TGCCTTA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-124a (v7.1 miRBase).", "TGCACTT_MIR519C_MIR519B_MIR519A": "Genes having at least one occurence of the motif TGCACTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-519c, hsa-miR-519b and hsa-miR-519a (v7.1 miRBase).", "TGTATGA_MIR4853P": "Genes having at least one occurence of the motif TGTATGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-485-3p (v7.1 miRBase).", "TGCTTTG_MIR330": "Genes having at least one occurence of the motif TGCTTTG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-330 (v7.1 miRBase).", "TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497": "Genes having at least one occurence of the motif TGCTGCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-15a, hsa-miR-16, hsa-miR-15b, hsa-miR-195, hsa-miR-424 and hsa-miR-497 (v7.1 miRBase).", "TTCCGTT_MIR191": "Genes having at least one occurence of the motif TTCCGTT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-191 (v7.1 miRBase).", "TGTGTGA_MIR377": "Genes having at least one occurence of the motif TGTGTGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-377 (v7.1 miRBase).", "TGGTGCT_MIR29A_MIR29B_MIR29C": "Genes having at least one occurence of the motif TGGTGCT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-29a, hsa-miR-29b and hsa-miR-29c (v7.1 miRBase).", "TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P": "Genes having at least one occurence of the motif TGTTTAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-30a-5p, hsa-miR-30c, hsa-miR-30d, hsa-miR-30b and hsa-miR-30e-5p (v7.1 miRBase).", "TTGCACT_MIR130A_MIR301_MIR130B": "Genes having at least one occurence of the motif TTGCACT in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-130a, hsa-miR-301 and hsa-miR-130b (v7.1 miRBase).", "TTGGAGA_MIR5155P_MIR519E": "Genes having at least one occurence of the motif TTGGAGA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-515-5p and hsa-miR-519e* (v7.1 miRBase).", "TTGGGAG_MIR150": "Genes having at least one occurence of the motif TTGGGAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-150 (v7.1 miRBase).", "TTGCCAA_MIR182": "Genes having at least one occurence of the motif TTGCCAA in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-182 (v7.1 miRBase).", "TTTGCAG_MIR518A2": "Genes having at least one occurence of the motif TTTGCAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-518a-2* (v7.1 miRBase).", "TTTGTAG_MIR520D": "Genes having at least one occurence of the motif TTTGTAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-520d* (v7.1 miRBase).", "TTTGCAC_MIR19A_MIR19B": "Genes having at least one occurence of the motif TTTGCAC in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNAs hsa-miR-19a and hsa-miR-19b (v7.1 miRBase).", "TTTTGAG_MIR373": "Genes having at least one occurence of the motif TTTTGAG in their 3' untranslated region. The motif represents putative target (that is, seed match) of human mature miRNA hsa-miR-373* (v7.1 miRBase).", "ADCYAP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P18509 (ADCYAP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ADNP_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9H2P0 (ADNP) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ALX4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9H161 (ALX4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ARHGAP35_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NRY4 (ARHGAP35) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "AEBP2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6ZN18 (AEBP2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ALKBH3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96Q83 (ALKBH3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ADA2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NZK5 (ADA2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "AHRR_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A9YTQ3 (AHRR) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ARID3B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IVW6 (ARID3B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ARNT2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9HBZ2 (ARNT2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ARID5B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14865 (ARID5B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ASXL2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q76L83 (ASXL2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ATM_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13315 (ATM) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ATOH8_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96SQ7 (ATOH8) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ASH1L_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NR48 (ASH1L) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ATF5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y2D1 (ATF5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BAHD1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TBE0 (BAHD1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ATF6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P18850 (ATF6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ATXN7L3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14CW9 (ATXN7L3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "AUTS2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8WXX7 (AUTS2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BANP_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N9N5 (BANP) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BARHL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BZE3 (BARHL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BCL6B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N143 (BCL6B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BARX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9HBU1 (BARX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BRF2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9HAW0 (BRF2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BRF1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q92994 (BRF1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BDP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A6H8Y1 (BDP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BARX2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UMQ3 (BARX2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BPTF_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q12830 (BPTF) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CASP3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P42574 (CASP3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CARM1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q86X55 (CARM1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "BRCA2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P51587 (BRCA2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CASP8AP2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UKL3 (CASP8AP2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CAVIN1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6NZI2 (CAVIN1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CBX5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P45973 (CBX5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CDX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P47902 (CDX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CDH4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P55283 (CDH4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CDC73_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6P1J9 (CDC73) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CBX7_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O95931 (CBX7) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CEBPE_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15744 (CEBPE) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CC2D1A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6P1N0 (CC2D1A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CDC5L_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q99459 (CDC5L) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CENPT_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96BT3 (CENPT) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CEBPZ_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q03701 (CEBPZ) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CHAF1A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13111 (CHAF1A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "COBLL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q53SF7 (COBLL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "COIL_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P38432 (COIL) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CHAMP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96JM3 (CHAMP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CIC_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96RK0 (CIC) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CREB3L2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q70SY1 (CREB3L2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CHAF1B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13112 (CHAF1B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CIITA_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P33076 (CIITA) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CREBL2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O60519 (CREBL2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CREB3L4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TEY5 (CREB3L4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CREB3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O43889 (CREB3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CSHL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14406 (CSHL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CTR9_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6PD62 (CTR9) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "CUX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P39880 (CUX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DICER1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UPY3 (DICER1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DLX2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q07687 (DLX2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DACH1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UI36 (DACH1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DBP_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q10586 (DBP) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DLX6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P56179 (DLX6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DLX4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q92988 (DLX4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DIDO1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BTC0 (DIDO1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DMRT1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y5R6 (DMRT1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DNMT1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P26358 (DNMT1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DPPA3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6W0C5 (DPPA3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DNMT3A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y6K1 (DNMT3A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DROSHA_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NRR4 (DROSHA) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "DYRK1A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13627 (DYRK1A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "EGFR_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P00533 (EGFR) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "EMX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q04741 (EMX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "EBNA1BP2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q99848 (EBNA1BP2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "E2F5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15329 (E2F5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "E2F2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14209 (E2F2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ELF5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UKW6 (ELF5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ERCC8_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13216 (ERCC8) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "EPC1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9H2F5 (EPC1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ELF2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15723 (ELF2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "F2RL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P55085 (F2RL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "F10_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P00742 (F10) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "EWSR1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q01844 (EWSR1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXC1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q12948 (FOXC1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXD3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UJU5 (FOXD3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXF2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q12947 (FOXF2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXF1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q12946 (FOXF1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXD2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O60548 (FOXD2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FEV_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q99581 (FEV) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXE1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O00358 (FOXE1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXJ2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9P0K8 (FOXJ2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXO4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P98177 (FOXO4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXG1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P55316 (FOXG1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXQ1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9C009 (FOXQ1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXR2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6PJQ5 (FOXR2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FOXN3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O00409 (FOXN3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GLI1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P08151 (GLI1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "FXR1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P51114 (FXR1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GLI3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P10071 (GLI3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GTF3A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q92664 (GTF3A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GLI4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P10075 (GLI4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GTF2A2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P52657 (GTF2A2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GTF3C1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q12789 (GTF3C1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GREB1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q4ZG55 (GREB1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GTF2E2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P29084 (GTF2E2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "GUCY1B1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q02153 (GUCY1B1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HAND1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O96004 (HAND1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "H1_6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P22492 (H1-6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HDAC8_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BY41 (HDAC8) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HDAC4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P56524 (HDAC4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HBZ_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P02008 (HBZ) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HEY2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UBP5 (HEY2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HES4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9HCC6 (HES4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HDGF_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P51858 (HDGF) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HES2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y543 (HES2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HJURP_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NCD3 (HJURP) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HHEX_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q03014 (HHEX) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HMCES_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96FZ2 (HMCES) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HMG20B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9P0W2 (HMG20B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXA13_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P31271 (HOXA13) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXA10_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P31260 (HOXA10) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXA7_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P31268 (HOXA7) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HMGA1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17096 (HMGA1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HMGB2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P26583 (HMGB2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXB7_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P09629 (HOXB7) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXA1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P49639 (HOXA1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXB4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17483 (HOXB4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXB6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17509 (HOXB6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXC13_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P31276 (HOXC13) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXD11_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P31277 (HOXD11) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXC11_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O43248 (HOXC11) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXD1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9GZZ0 (HOXD1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HOXC6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P09630 (HOXC6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HSD17B8_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q92506 (HSD17B8) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HSF2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q03933 (HSF2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "HSF4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9ULV5 (HSF4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "IGF1R_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P08069 (IGF1R) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ID2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q02363 (ID2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ILK_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13418 (ILK) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ID1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P41134 (ID1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "IGLV5_37_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A0A075B6J1 (IGLV5-37) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "IRX3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P78415 (IRX3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "IRX2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BZI1 (IRX2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "INSM2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96T92 (INSM2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "KAT2A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q92830 (KAT2A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "IRF5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13568 (IRF5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "KDM1B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NB78 (KDM1B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "KLF14_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TD94 (KLF14) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "KAT5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q92993 (KAT5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LAMB3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13751 (LAMB3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LAMTOR5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O43504 (LAMTOR5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "KLF7_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O75840 (KLF7) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "KMT2D_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O14686 (KMT2D) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LHX3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UBR4 (LHX3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LCORL_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N3X6 (LCORL) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LHX4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q969G2 (LHX4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LMNB2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q03252 (LMNB2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LMX1B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O60663 (LMX1B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LHX2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P50458 (LHX2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LHX9_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NQ69 (LHX9) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MAP2K1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q02750 (MAP2K1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "LMTK3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96Q04 (LMTK3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MCM2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P49736 (MCM2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MAPK3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P27361 (MAPK3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MAML1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q92585 (MAML1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MAFG_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O15525 (MAFG) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MCM5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P33992 (MCM5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MCM3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P25205 (MCM3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MCRS1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96EZ8 (MCRS1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MDM2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q00987 (MDM2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MED25_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q71SY5 (MED25) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MED16_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y2X0 (MED16) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "METTL14_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9HCE5 (METTL14) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "METHYLCYTOSINE_DIOXYGENASE_TET_UNIPROT_A0A023HHK9_UNREVIEWED_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A0A023HHK9 (METHYLCYTOSINE_DIOXYGENASE_TET_UNIPROT_A0A023HHK9_UNREVIEWED) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MEF2C_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q06413 (MEF2C) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MNX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P50219 (MNX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MEF2D_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14814 (MEF2D) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MPHOSPH8_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q99549 (MPHOSPH8) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MIER1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N108 (MIER1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MSX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P28360 (MSX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MSX2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P35548 (MSX2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MTHFD1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P11586 (MTHFD1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MYBL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P10243 (MYBL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MYF6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P23409 (MYF6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MXD1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q05195 (MXD1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NEUROD2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15784 (NEUROD2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NCOA2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15596 (NCOA2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MYOCD_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IZQ8 (MYOCD) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NCOA6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14686 (NCOA6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NAB2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15742 (NAB2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "MZF1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P28698 (MZF1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NCOA4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13772 (NCOA4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NEUROG3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y4Z2 (NEUROG3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NFE2L3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y4A8 (NFE2L3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NFE2L1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14494 (NFE2L1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NKX2_8_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O15522 (NKX2-8) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NKX6_1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P78426 (NKX6-1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NFXL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6ZNB6 (NFXL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NFKBIA_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P25963 (NFKBIA) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NKX2_2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O95096 (NKX2-2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NME2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P22392 (NME2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NKX2_3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TAU0 (NKX2-3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NKX2_5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P52952 (NKX2-5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NOTCH3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UM47 (NOTCH3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NPAT_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14207 (NPAT) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NR1D1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P20393 (NR1D1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NR4A2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P43354 (NR4A2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NPM1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P06748 (NPM1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NR1I2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O75469 (NR1I2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NR5A1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13285 (NR5A1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NR2E3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y5X4 (NR2E3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NR1H4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96RI1 (NR1H4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NUFIP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UHK0 (NUFIP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NUP214_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P35658 (NUP214) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "NR0B1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P51843 (NR0B1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PAF1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N7H5 (PAF1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "OVOL3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O00110 (OVOL3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PBRM1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q86U86 (PBRM1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PAX8_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q06710 (PAX8) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PAX3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P23760 (PAX3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PBXIP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96AQ6 (PBXIP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PCGF6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BYE7 (PCGF6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PCGF1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BSM1 (PCGF1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PER1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O15534 (PER1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PAX7_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P23759 (PAX7) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PAX6_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P26367 (PAX6) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PGBD5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N414 (PGBD5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PHB2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q99623 (PHB2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PGM3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O95394 (PGM3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PHF21A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96BD5 (PHF21A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PIAS4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N2W9 (PIAS4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PPARA_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q07869 (PPARA) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PPARGC1A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UBK2 (PPARGC1A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PITX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P78337 (PITX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PRDM12_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9H4Q4 (PRDM12) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PRDM5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NQX1 (PRDM5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PRMT5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O14744 (PRMT5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "POU2AF1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q16633 (POU2AF1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PRDM4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UKN5 (PRDM4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PTTG1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O95997 (PTTG1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PSIP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O75475 (PSIP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PSMB5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P28074 (PSMB5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RARB_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P10826 (RARB) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PRKDC_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P78527 (PRKDC) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "PTPRA_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P18433 (PTPRA) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RBL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P28749 (RBL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RAX2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96IS3 (RAX2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RAG1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P15918 (RAG1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RBM15_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96T37 (RBM15) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RBM17_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96I25 (RBM17) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RBMX_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P38159 (RBMX) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "REPIN1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BWE0 (REPIN1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RPA2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P15927 (RPA2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RFX7_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q2KHR2 (RFX7) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RLF_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13129 (RLF) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RPA1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P27694 (RPA1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RORA_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P35398 (RORA) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RBM34_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P42696 (RBM34) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RUVBL2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y230 (RUVBL2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RUVBL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y265 (RUVBL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SAFB2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14151 (SAFB2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SIGMAR1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q99720 (SIGMAR1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SETBP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y6X0 (SETBP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SIRT3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NTG7 (SIRT3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SIPA1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96FS4 (SIPA1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "RYBP_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N488 (RYBP) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SALL4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UJQ4 (SALL4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SETD7_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8WTS6 (SETD7) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SETD1A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O15047 (SETD1A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SFMBT1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UHJ3 (SFMBT1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SIX4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UIU6 (SIX4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SIX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15475 (SIX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SKP2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13309 (SKP2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SMARCA1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P28370 (SMARCA1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SKIL_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P12757 (SKIL) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SMCHD1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A6NHR9 (SMCHD1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SNAPC2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13487 (SNAPC2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SNAPC4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q5SXM2 (SNAPC4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SNAI1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O95863 (SNAI1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SMN1_SMN2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q16637 (SMN1 or SMN2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SOD1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P00441 (SOD1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SNIP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TAD8 (SNIP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SNRNP70_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P08621 (SNRNP70) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SOX10_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P56693 (SOX10) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SOX11_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P35716 (SOX11) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SOX15_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O60248 (SOX15) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SQSTM1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13501 (SQSTM1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SRPK2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P78362 (SRPK2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SOX3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P41225 (SOX3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SRPK1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96SB4 (SRPK1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SRSF9_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13242 (SRSF9) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "STN1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9H668 (STN1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SS18_SSX1_FUSION_UNIPROT_Q8IZH1_UNREVIEWED_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IZH1 (SS18_SSX1 FUSION_UNIPROT_Q8IZH1_UNREVIEWED) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SVIL_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O95425 (SVIL) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SYNCRIP_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O60506 (SYNCRIP) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SUMO1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P63165 (SUMO1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SUPT20H_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NEM7 (SUPT20H) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "SUPT16H_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y5B9 (SUPT16H) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TAF9B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9HBM6 (TAF9B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TAFAZZIN_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q16635 (TAFAZZIN) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TASOR_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UK61 (TASOR) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TBPL1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P62380 (TBPL1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TDRD3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9H7E2 (TDRD3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TBX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O43435 (TBX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TCOF1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13428 (TCOF1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TBX3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O15119 (TBX3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TERF2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15554 (TERF2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TERT_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O14746 (TERT) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TFCP2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q12800 (TFCP2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TFDP2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14188 (TFDP2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TFAM_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q00059 (TFAM) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TERF1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P54274 (TERF1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TET1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NFU7 (TET1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "THRAP3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y2W1 (THRAP3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TEAD2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15562 (TEAD2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TFEB_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P19484 (TFEB) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "THRA_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P10827 (THRA) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TRIP13_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15645 (TRIP13) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TOP2B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q02880 (TOP2B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TUBG1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P23258 (TUBG1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TOX4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O94842 (TOX4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "TSHZ1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6ZSZ6 (TSHZ1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "UBE2I_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P63279 (UBE2I) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "VRTN_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9H8Y1 (VRTN) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "WIZ_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O95785 (WIZ) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "WDHD1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O75717 (WDHD1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "WRN_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14191 (WRN) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "XPO1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O14980 (XPO1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "YBX3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P16989 (YBX3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZA_UNIPROT_Q9UM89_UNREVIEWED_GENES_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UM89 (ZA_UNIPROT_Q9UM89_UNREVIEWED_GENES) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "UBN1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NPG3 (UBN1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "YBX1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P67809 (YBX1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "WRNIP1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96S55 (WRNIP1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZBED4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O75132 (ZBED4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZBTB1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y2K1 (ZBTB1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZBED5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q49AG3 (ZBED5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZBTB12_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y330 (ZBTB12) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZBTB18_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q99592 (ZBTB18) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZBTB49_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6ZSB9 (ZBTB49) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZBTB5_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O15062 (ZBTB5) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZFHX3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15911 (ZFHX3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZBTB44_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NCP5 (ZBTB44) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZFP28_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NHY6 (ZFP28) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZFP82_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N141 (ZFP82) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZFP36L1_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q07352 (ZFP36L1) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZFP37_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y6Q3 (ZFP37) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZC3H11A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O75152 (ZC3H11A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZFP3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96NJ6 (ZFP3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZMYM2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UBW7 (ZMYM2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZMYND11_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15326 (ZMYND11) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZFP91_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96JP5 (ZFP91) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF112_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UJU3 (ZNF112) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZIM3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96PE6 (ZIM3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF101_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IZC7 (ZNF101) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF133_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P52736 (ZNF133) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF136_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P52737 (ZNF136) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF134_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P52741 (ZNF134) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF10_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P21506 (ZNF10) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF138_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P52744 (ZNF138) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF157_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P51786 (ZNF157) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF165_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P49910 (ZNF165) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF140_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P52738 (ZNF140) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF169_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q14929 (ZNF169) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF146_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q15072 (ZNF146) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF16_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17020 (ZNF16) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF19_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17023 (ZNF19) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF175_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y473 (ZNF175) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF202_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O95125 (ZNF202) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF20_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17024 (ZNF20) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF211_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q13398 (ZNF211) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF197_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O14709 (ZNF197) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF214_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UL59 (ZNF214) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF184_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q99676 (ZNF184) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF213_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O14771 (ZNF213) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF223_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UK11 (ZNF223) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF23_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17027 (ZNF23) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF236_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UL36 (ZNF236) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF224_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NZL3 (ZNF224) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF239_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q16600 (ZNF239) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF248_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NDW4 (ZNF248) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF22_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17026 (ZNF22) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF250_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P15622 (ZNF250) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF257_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y2Q1 (ZNF257) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF260_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q3ZCT1 (ZNF260) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF26_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17031 (ZNF26) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF292_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O60281 (ZNF292) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF302_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NR11 (ZNF302) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF274_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96GC6 (ZNF274) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF282_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UDV7 (ZNF282) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BSG1 (ZNF2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF30_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17039 (ZNF30) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF318_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q5VUA4 (ZNF318) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF322_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6U7Q0 (ZNF322) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF331_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NQX6 (ZNF331) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF329_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q86UD4 (ZNF329) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF33A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q06730 (ZNF33A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF34_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IZ26 (ZNF34) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF354A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O60765 (ZNF354A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF320_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A2RRD8 (ZNF320) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF354C_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q86Y25 (ZNF354C) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF354B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96LW1 (ZNF354B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF350_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9GZX5 (ZNF350) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF37A_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17032 (ZNF37A) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF362_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q5T0B9 (ZNF362) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF404_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q494X3 (ZNF404) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF391_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9UJN7 (ZNF391) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF394_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q53GI3 (ZNF394) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF416_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BWM5 (ZNF416) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF418_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TF45 (ZNF418) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF410_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q86VK4 (ZNF410) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF419_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96HQ0 (ZNF419) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF407_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9C0G0 (ZNF407) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF41_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P51814 (ZNF41) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF433_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N7K0 (ZNF433) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF426_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BUY5 (ZNF426) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF445_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P59923 (ZNF445) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF436_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9C0F3 (ZNF436) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF454_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N9F8 (ZNF454) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF423_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q2M1K9 (ZNF423) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF488_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96MN9 (ZNF488) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF491_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N8L2 (ZNF491) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF486_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96H40 (ZNF486) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF490_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9ULM2 (ZNF490) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF493_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6ZR52 (ZNF493) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF501_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96CX3 (ZNF501) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF502_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TBZ5 (ZNF502) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF510_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y2H8 (ZNF510) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF514_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96K75 (ZNF514) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF507_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TCN5 (ZNF507) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF512_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96ME7 (ZNF512) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF512B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96KM6 (ZNF512B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF530_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6P9A1 (ZNF530) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF529_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6P280 (ZNF529) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF513_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N8E2 (ZNF513) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF524_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96C55 (ZNF524) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF544_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6NX49 (ZNF544) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF532_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9HCE3 (ZNF532) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF528_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q3MIS6 (ZNF528) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF548_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NEK5 (ZNF548) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF547_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IVP9 (ZNF547) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF560_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96MR9 (ZNF560) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF555_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NEP9 (ZNF555) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF558_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96NG5 (ZNF558) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF549_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6P9A3 (ZNF549) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF563_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TA94 (ZNF563) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF561_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N587 (ZNF561) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF577_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9BSK1 (ZNF577) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF579_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NAF0 (ZNF579) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF581_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9P0T4 (ZNF581) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF582_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96NG8 (ZNF582) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF585B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q52M93 (ZNF585B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF586_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9NXT0 (ZNF586) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF584_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IVC4 (ZNF584) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF595_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IYB9 (ZNF595) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF589_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q86UQ0 (ZNF589) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF596_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TC21 (ZNF596) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF622_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q969S3 (ZNF622) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF597_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96LX8 (ZNF597) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF592_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q92610 (ZNF592) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF610_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N9Z0 (ZNF610) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF626_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q68DY1 (ZNF626) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF618_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q5T7W0 (ZNF618) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF623_TARGET_GENES": "Genes containing one or more binding sites for UniProt:O75123 (ZNF623) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF660_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6AZW8 (ZNF660) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF667_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q5HYK9 (ZNF667) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF669_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96BR6 (ZNF669) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF664_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N3J9 (ZNF664) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF677_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q86XU0 (ZNF677) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF704_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6ZNC4 (ZNF704) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF707_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96C28 (ZNF707) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF697_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q5TEC3 (ZNF697) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF680_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NEM1 (ZNF680) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF708_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17019 (ZNF708) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF746_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6NUN9 (ZNF746) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF711_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y462 (ZNF711) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF776_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q68DI1 (ZNF776) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF774_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q6NX45 (ZNF774) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF740_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NDX6 (ZNF740) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF777_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9ULD5 (ZNF777) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF768_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9H5H4 (ZNF768) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF781_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N8C0 (ZNF781) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF785_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A8K8V0 (ZNF785) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF784_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NCA9 (ZNF784) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF766_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q5HY98 (ZNF766) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF791_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q3KP31 (ZNF791) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF837_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96EG3 (ZNF837) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF816_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q0VGE8 (ZNF816) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF7_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17097 (ZNF7) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF830_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96NB3 (ZNF830) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF85_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q03923 (ZNF85) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN18_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8TBC5 (ZSCAN18) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF843_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8N446 (ZNF843) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN23_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q3MJ62 (ZSCAN23) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF8_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P17098 (ZNF8) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN26_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q16670 (ZSCAN26) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZNF92_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q03936 (ZNF92) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN21_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q9Y5A6 (ZSCAN21) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN5B_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A6NJL1 (ZSCAN5B) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN2_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q7Z7L9 (ZSCAN2) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN31_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q96LW9 (ZSCAN31) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN30_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q86W11 (ZSCAN30) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN5C_TARGET_GENES": "Genes containing one or more binding sites for UniProt:A6NGD5 (ZSCAN5C) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "AAANWWTGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M144 AAANWWTGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "ZZZ3_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8IYH5 (ZZZ3) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN5DP_TARGET_GENES": "Genes containing one or more binding sites for UniProt:P0CG00 (ZSCAN5DP) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "ZSCAN4_TARGET_GENES": "Genes containing one or more binding sites for UniProt:Q8NAM6 (ZSCAN4) in their promoter regions (TSS -1000,+100 bp) as identified by GTRD version 20.06 ChIP-seq harmonization.", "AAAYRNCTG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M77 AAAYRNCTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "AAAYWAACM_HFH4_01": "Genes having at least one occurrence of the highly conserved motif M139 AAAYWAACM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXJ1 [GeneSymbol=FOXJ1] transcription factor binding site V$HFH4_01 (v7.4 TRANSFAC).", "AACWWCAANK_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M108 AACWWCAANK in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "AACYNNNNTTCCS_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M113 AACYNNNNTTCCS in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "AAGWWRNYGGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M63 AAGWWRNYGGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "ACAWYAAAG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M142 ACAWYAAAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "AACTTT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M17 AACTTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "ACTAYRNNNCCCR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M4 ACTAYRNNNCCCR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "ACTWSNACTNY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M105 ACTWSNACTNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "ACAWNRNSRCGG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M103 ACAWNRNSRCGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "ACCTGTTG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M57 ACCTGTTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "AHRARNT_02": "Genes having at least one occurrence of the motif GRGKATYGCGTGMCWNSCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AHR [GeneSymbol=AHR] transcription factor binding site V$AHRARNT_02 (v7.4 TRANSFAC).", "AGCYRWTTC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M135 AGCYRWTTC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "AFP1_Q6": "Genes having at least one occurrence of the motif ATTAAYTRCAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZHX2 [GeneSymbol=ZHX2] transcription factor binding site V$AFP1_Q6 (v7.4 TRANSFAC).", "AHRARNT_01": "Genes having at least one occurrence of the motif KNNKNNTYGCGTGCMS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AHR [GeneSymbol=AHR] transcription factor binding site V$AHRARNT_01 (v7.4 TRANSFAC).", "AHR_01": "Genes having at least one occurrence of the motif CCYCNRRSTNGCGTGASA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AHR [GeneSymbol=AHR] transcription factor binding site V$AHR_01 (v7.4 TRANSFAC).", "AHR_Q5": "Genes having at least one occurrence of the motif NTNGCGTGNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AHR [GeneSymbol=AHR] transcription factor binding site V$AHR_Q5 (v7.4 TRANSFAC).", "ALX4_01": "Genes having at least one occurrence of the motif CCTGAGAATAATC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ALX4 [GeneSymbol=ALX4] transcription factor binding site V$ALX4_01 (v7.4 TRANSFAC).", "ALPHACP1_01": "Genes having at least one occurrence of the motif CAGCCAATGAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PCBP1 [GeneSymbol=PCBP1] transcription factor binding site V$ALPHACP1_01 (v7.4 TRANSFAC).", "AMEF2_Q6": "Genes having at least one occurrence of the motif CKGDYTAAAAATAACYMM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$AMEF2_Q6 (v7.4 TRANSFAC).", "AML1_01": "Genes having at least one occurrence of the motif TGTGGT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RUNX1 [GeneSymbol=RUNX1] transcription factor binding site V$AML1_01 (v7.4 TRANSFAC).", "AP1FJ_Q2": "Genes having at least one occurrence of the motif RSTGACTNMNW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1FJ_Q2 (v7.4 TRANSFAC).", "AML1_Q6": "Genes having at least one occurrence of the motif TGTGGT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RUNX1 [GeneSymbol=RUNX1] transcription factor binding site V$AML1_Q6 (v7.4 TRANSFAC).", "AML_Q6": "Genes having at least one occurrence of the motif NNGKNTGTGGTTWNC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RUNX1 [GeneSymbol=RUNX1] transcription factor binding site V$AML_Q6 (v7.4 TRANSFAC).", "AP1_C": "Genes having at least one occurrence of the motif NTGASTCAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_C (v7.4 TRANSFAC).", "AP1_01": "Genes having at least one occurrence of the motif NNNTGAGTCAKCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_01 (v7.4 TRANSFAC).", "AP1_Q2_01": "Genes having at least one occurrence of the motif TGACTCANNSKN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_Q2_01 (v7.4 TRANSFAC).", "AP1_Q2": "Genes having at least one occurrence of the motif RSTGACTNANW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_Q2 (v7.4 TRANSFAC).", "AP1_Q4_01": "Genes having at least one occurrence of the motif TGAGTCAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_Q4_01 (v7.4 TRANSFAC).", "AP1_Q6": "Genes having at least one occurrence of the motif NNTGACTCANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_Q6 (v7.4 TRANSFAC).", "AP1_Q4": "Genes having at least one occurrence of the motif RGTGACTMANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_Q4 (v7.4 TRANSFAC).", "AP1_Q6_01": "Genes having at least one occurrence of the motif NTGACTCAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_Q6_01 (v7.4 TRANSFAC).", "AP2ALPHA_01": "Genes having at least one occurrence of the motif GCCNNNRGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFAP2A [GeneSymbol=TFAP2A] transcription factor binding site V$AP2ALPHA_01 (v7.4 TRANSFAC).", "AP2GAMMA_01": "Genes having at least one occurrence of the motif GCCYNNGGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFAP2C [GeneSymbol=TFAP2C] transcription factor binding site V$AP2GAMMA_01 (v7.4 TRANSFAC).", "AP2_Q3": "Genes having at least one occurrence of the motif GSCCSCRGGCNRNRNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GTF3A [GeneSymbol=GTF3A] transcription factor binding site V$AP2_Q3 (v7.4 TRANSFAC).", "AP2REP_01": "Genes having at least one occurrence of the motif CAGTGGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the KLF12 [GeneSymbol=KLF12] transcription factor binding site V$AP2REP_01 (v7.4 TRANSFAC).", "AP2_Q6": "Genes having at least one occurrence of the motif MKCCCSCNGGCG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GTF3A [GeneSymbol=GTF3A] transcription factor binding site V$AP2_Q6 (v7.4 TRANSFAC).", "AP2_Q6_01": "Genes having at least one occurrence of the motif SNNNCCNCAGGCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GTF3A [GeneSymbol=GTF3A] transcription factor binding site V$AP2_Q6_01 (v7.4 TRANSFAC).", "AP3_Q6": "Genes having at least one occurrence of the motif TCYMMATT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$AP3_Q6 (v7.4 TRANSFAC).", "AP4_Q6": "Genes having at least one occurrence of the motif CWCAGCTGGN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFAP4 [GeneSymbol=TFAP4] transcription factor binding site V$AP4_Q6 (v7.4 TRANSFAC).", "AP4_Q5": "Genes having at least one occurrence of the motif VDCAGCTGNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFAP4 [GeneSymbol=TFAP4] transcription factor binding site V$AP4_Q5 (v7.4 TRANSFAC).", "AP4_01": "Genes having at least one occurrence of the motif WGARYCAGCTGYGGNCNK in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFAP4 [GeneSymbol=TFAP4] transcription factor binding site V$AP4_01 (v7.4 TRANSFAC).", "AREB6_01": "Genes having at least one occurrence of the motif NNYNYACCTGWVT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF8 [GeneSymbol=TCF8] transcription factor binding site V$AREB6_01 (v7.4 TRANSFAC).", "AREB6_02": "Genes having at least one occurrence of the motif WNWCACCTGWNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF8 [GeneSymbol=TCF8] transcription factor binding site V$AREB6_02 (v7.4 TRANSFAC).", "AP4_Q6_01": "Genes having at least one occurrence of the motif RNCAGCTGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFAP4 [GeneSymbol=TFAP4] transcription factor binding site V$AP4_Q6_01 (v7.4 TRANSFAC).", "AREB6_03": "Genes having at least one occurrence of the motif VNRCACCTGKNC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF8 [GeneSymbol=TCF8] transcription factor binding site V$AREB6_03 (v7.4 TRANSFAC).", "ARGGGTTAA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M65 ARGGGTTAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "AREB6_04": "Genes having at least one occurrence of the motif CBGTTTSNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF8 [GeneSymbol=TCF8] transcription factor binding site V$AREB6_04 (v7.4 TRANSFAC).", "ARNT_02": "Genes having at least one occurrence of the motif NNNNNRTCACGTGAYNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ARNT [GeneSymbol=ARNT] transcription factor binding site V$ARNT_02 (v7.4 TRANSFAC).", "ARNT_01": "Genes having at least one occurrence of the motif NDDNNCACGTGNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ARNT [GeneSymbol=ARNT] transcription factor binding site V$ARNT_01 (v7.4 TRANSFAC).", "AR_01": "Genes having at least one occurrence of the motif GGTACANNRTGTTCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AR [GeneSymbol=AR] transcription factor binding site V$AR_01 (v7.4 TRANSFAC).", "ARP1_01": "Genes having at least one occurrence of the motif TGARCCYTTGAMCCCW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PITX2 [GeneSymbol=PITX2] transcription factor binding site V$ARP1_01 (v7.4 TRANSFAC).", "AR_03": "Genes having at least one occurrence of the motif NNNNNNRGNACRNNGTGTTCTNNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AR [GeneSymbol=AR] transcription factor binding site V$AR_03 (v7.4 TRANSFAC).", "AR_02": "Genes having at least one occurrence of the motif NNNGNRRGNACANNGTGTTCTNNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AR [GeneSymbol=AR] transcription factor binding site V$AR_02 (v7.4 TRANSFAC).", "AR_Q2": "Genes having at least one occurrence of the motif AGWACATNWTGTTCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AR [GeneSymbol=AR] transcription factor binding site V$AR_Q2 (v7.4 TRANSFAC).", "AR_Q6": "Genes having at least one occurrence of the motif WGAGCANRN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the AR [GeneSymbol=AR] transcription factor binding site V$AR_Q6 (v7.4 TRANSFAC).", "ATCMNTCCGY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M99 ATCMNTCCGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "ATF1_Q6": "Genes having at least one occurrence of the motif CYYTGACGTCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ATF1 [GeneSymbol=ATF1] transcription factor binding site V$ATF1_Q6 (v7.4 TRANSFAC).", "ATF6_01": "Genes having at least one occurrence of the motif TGACGTGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ATF6 [GeneSymbol=ATF6] transcription factor binding site V$ATF6_01 (v7.4 TRANSFAC).", "ATF4_Q2": "Genes having at least one occurrence of the motif CVTGACGYMABG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ATF4 [GeneSymbol=ATF4] transcription factor binding site V$ATF4_Q2 (v7.4 TRANSFAC).", "ATF3_Q6": "Genes having at least one occurrence of the motif CBCTGACGTCANCS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ATF3 [GeneSymbol=ATF3] transcription factor binding site V$ATF3_Q6 (v7.4 TRANSFAC).", "ATF_01": "Genes having at least one occurrence of the motif CNSTGACGTNNNYC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$ATF_01 (v7.4 TRANSFAC).", "ATF_B": "Genes having at least one occurrence of the motif NTGACGTCANYS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$ATF_B (v7.4 TRANSFAC).", "BACH1_01": "Genes having at least one occurrence of the motif NNSATGAGTCATGNT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the BACH1 [GeneSymbol=BACH1] transcription factor binding site V$BACH1_01 (v7.4 TRANSFAC).", "ATGGYGGA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M102 ATGGYGGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "BACH2_01": "Genes having at least one occurrence of the motif SRTGAGTCANC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the BACH2 [GeneSymbol=BACH2] transcription factor binding site V$BACH2_01 (v7.4 TRANSFAC).", "CACBINDINGPROTEIN_Q6": "Genes having at least one occurrence of the motif GRGGSTGGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$CACBINDINGPROTEIN_Q6 (v7.4 TRANSFAC).", "BRN2_01": "Genes having at least one occurrence of the motif NNCATNSRWAATNMRN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU3F2 [GeneSymbol=POU3F2] transcription factor binding site V$BRN2_01 (v7.4 TRANSFAC).", "CACCCBINDINGFACTOR_Q6": "Genes having at least one occurrence of the motif CANCCNNWGGGTGDGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$CACCCBINDINGFACTOR_Q6 (v7.4 TRANSFAC).", "CACGTG_MYC_Q2": "Genes having at least one occurrence of the highly conserved motif M2 CACGTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYC [GeneSymbol=MYC] transcription factor binding site V$MYC_Q2 (v7.4 TRANSFAC).", "CAGNYGKNAAA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M160 CAGNYGKNAAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CAGNWMCNNNGAC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M143 CAGNWMCNNNGAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CATRRAGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M134 CATRRAGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CART1_01": "Genes having at least one occurrence of the motif NNNTAATTNNCATTANCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CART1 [GeneSymbol=CART1] transcription factor binding site V$CART1_01 (v7.4 TRANSFAC).", "CAGCTG_AP4_Q5": "Genes having at least one occurrence of the highly conserved motif M15 CAGCTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the REPIN1 [GeneSymbol=REPIN1] transcription factor binding site V$AP4_Q5 (v7.4 TRANSFAC).", "CAGGTA_AREB6_01": "Genes having at least one occurrence of the highly conserved motif M76 CAGGTA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF8 [GeneSymbol=TCF8] transcription factor binding site V$AREB6_01 (v7.4 TRANSFAC).", "CCAATNNSNNNGCG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M104 CCAATNNSNNNGCG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CCANNAGRKGGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M45 CCANNAGRKGGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CATTGTYY_SOX9_B1": "Genes having at least one occurrence of the highly conserved motif M49 CATTGTYY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SOX9 [GeneSymbol=SOX9] transcription factor binding site V$SOX9_B1 (v7.4 TRANSFAC).", "CCAWNWWNNNGGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M165 CCAWNWWNNNGGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CCAWWNAAGG_SRF_Q4": "Genes having at least one occurrence of the highly conserved motif M121 CCAWWNAAGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SRF [GeneSymbol=SRF] transcription factor binding site V$SRF_Q4 (v7.4 TRANSFAC).", "CCCNNNNNNAAGWT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M158 CCCNNNNNNAAGWT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CCAWYNNGAAR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M124 CCAWYNNGAAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CCGNMNNTNACG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M106 CCGNMNNTNACG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CCCNNGGGAR_OLF1_01": "Genes having at least one occurrence of the highly conserved motif M130 CCCNNGGGAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EBF2 [GeneSymbol=EBF2] transcription factor binding site V$OLF1_01 (v7.4 TRANSFAC).", "CDPCR1_01": "Genes having at least one occurrence of the motif NATCGATCGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CUTL1 [GeneSymbol=CUTL1] transcription factor binding site V$CDPCR1_01 (v7.4 TRANSFAC).", "CCTNTMAGA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M167 CCTNTMAGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CDC5_01": "Genes having at least one occurrence of the motif GATTTAACATAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CDC5L [GeneSymbol=CDC5L] transcription factor binding site V$CDC5_01 (v7.4 TRANSFAC).", "CDPCR3_01": "Genes having at least one occurrence of the motif CACCRATANNTATBG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CUTL1 [GeneSymbol=CUTL1] transcription factor binding site V$CDPCR3_01 (v7.4 TRANSFAC).", "CDPCR3HD_01": "Genes having at least one occurrence of the motif NATYGATSSS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CUTL1 [GeneSymbol=CUTL1] transcription factor binding site V$CDPCR3HD_01 (v7.4 TRANSFAC).", "CDP_02": "Genes having at least one occurrence of the motif NWNATCGATTANYNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CUTL1 [GeneSymbol=CUTL1] transcription factor binding site V$CDP_02 (v7.4 TRANSFAC).", "CDP_01": "Genes having at least one occurrence of the motif CCAATAATCGAT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CUTL1 [GeneSymbol=CUTL1] transcription factor binding site V$CDP_01 (v7.4 TRANSFAC).", "CEBPA_01": "Genes having at least one occurrence of the motif NNATTRCNNAANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPA [GeneSymbol=CEBPA] transcription factor binding site V$CEBPA_01 (v7.4 TRANSFAC).", "CDX2_Q5": "Genes having at least one occurrence of the motif ANANTTTTATKRCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CDX2 [GeneSymbol=CDX2] transcription factor binding site V$CDX2_Q5 (v7.4 TRANSFAC).", "CEBPB_02": "Genes having at least one occurrence of the motif NKNTTGCNYAAYNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPB [GeneSymbol=CEBPB] transcription factor binding site V$CEBPB_02 (v7.4 TRANSFAC).", "CEBPB_01": "Genes having at least one occurrence of the motif RNRTKDNGMAAKNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPB [GeneSymbol=CEBPB] transcription factor binding site V$CEBPB_01 (v7.4 TRANSFAC).", "CEBPGAMMA_Q6": "Genes having at least one occurrence of the motif CTBATTTCARAAW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPG [GeneSymbol=CEBPG] transcription factor binding site V$CEBPGAMMA_Q6 (v7.4 TRANSFAC).", "CEBPDELTA_Q6": "Genes having at least one occurrence of the motif MATTKCNTMAYY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPD [GeneSymbol=CEBPD] transcription factor binding site V$CEBPDELTA_Q6 (v7.4 TRANSFAC).", "CEBP_C": "Genes having at least one occurrence of the motif NGWVTKNKGYAAKNSAYA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPA [GeneSymbol=CEBPA] transcription factor binding site V$CEBP_C (v7.4 TRANSFAC).", "CEBP_01": "Genes having at least one occurrence of the motif NNTKTGGWNANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPA [GeneSymbol=CEBPA] transcription factor binding site V$CEBP_01 (v7.4 TRANSFAC).", "CEBP_Q2": "Genes having at least one occurrence of the motif NNATTGCNNAANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPA [GeneSymbol=CEBPA] transcription factor binding site V$CEBP_Q2 (v7.4 TRANSFAC).", "CEBP_Q2_01": "Genes having at least one occurrence of the motif NTTRCNNAANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPA [GeneSymbol=CEBPA] transcription factor binding site V$CEBP_Q2_01 (v7.4 TRANSFAC).", "CETS1P54_01": "Genes having at least one occurrence of the motif NCMGGAWGYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ETS1 [GeneSymbol=ETS1] transcription factor binding site V$CETS1P54_01 (v7.4 TRANSFAC).", "CEBP_Q3": "Genes having at least one occurrence of the motif NNNTKNNGNAAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPA [GeneSymbol=CEBPA] transcription factor binding site V$CEBP_Q3 (v7.4 TRANSFAC).", "CGGAARNGGCNG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M81 CGGAARNGGCNG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CHX10_01": "Genes having at least one occurrence of the motif NNNTAATTAGCNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the VSX1 [GeneSymbol=VSX1] transcription factor binding site V$CHX10_01 (v7.4 TRANSFAC).", "CHOP_01": "Genes having at least one occurrence of the motif NNRTGCAATMCCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the DDIT3 [GeneSymbol=DDIT3], CEBPA DIFF GENES transcription factor binding site V$CHOP_01 (v7.4 TRANSFAC).", "CIZ_01": "Genes having at least one occurrence of the motif SAAAAANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZNF384 [GeneSymbol=ZNF384] transcription factor binding site V$CIZ_01 (v7.4 TRANSFAC).", "CGTSACG_PAX3_B": "Genes having at least one occurrence of the highly conserved motif M70 CGTSACG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX3 [GeneSymbol=PAX3] transcription factor binding site V$PAX3_B (v7.4 TRANSFAC).", "COMP1_01": "Genes having at least one occurrence of the motif NVTNWTGATTGACNACAAVARRBN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYOG [GeneSymbol=MYOG] transcription factor binding site V$COMP1_01 (v7.4 TRANSFAC).", "CMYB_01": "Genes having at least one occurrence of the motif NCNRNNGRCNGTTGGKGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYB [GeneSymbol=MYB] transcription factor binding site V$CMYB_01 (v7.4 TRANSFAC).", "COREBINDINGFACTOR_Q6": "Genes having at least one occurrence of the motif TGTGGTTW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CBFA2T2 [GeneSymbol=CBFA2T2], CBFA2T3 [GeneSymbol=CBFA2T3] transcription factor binding site V$COREBINDINGFACTOR_Q6 (v7.4 TRANSFAC).", "COUP_DR1_Q6": "Genes having at least one occurrence of the motif TGACCTTTGACCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PITX2 [GeneSymbol=PITX2] transcription factor binding site V$COUP_DR1_Q6 (v7.4 TRANSFAC).", "CP2_02": "Genes having at least one occurrence of the motif GCTGGNTNGNNCYNG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFCP2 [GeneSymbol=TFCP2] transcription factor binding site V$CP2_02 (v7.4 TRANSFAC).", "CP2_01": "Genes having at least one occurrence of the motif GCHCDAMCCAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TFCP2 [GeneSymbol=TFCP2] transcription factor binding site V$CP2_01 (v7.4 TRANSFAC).", "COUP_01": "Genes having at least one occurrence of the motif TGAMCTTTGMMCYT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HNF4A [GeneSymbol=HNF4A] transcription factor binding site V$COUP_01 (v7.4 TRANSFAC).", "CREBP1CJUN_01": "Genes having at least one occurrence of the motif TGACGTYA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN], ATF2 [GeneSymbol=ATF2] transcription factor binding site V$CREBP1CJUN_01 (v7.4 TRANSFAC).", "CREBP1_Q2": "Genes having at least one occurrence of the motif VGTGACGTMACN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ATF2 [GeneSymbol=ATF2] transcription factor binding site V$CREBP1_Q2 (v7.4 TRANSFAC).", "CREBP1_01": "Genes having at least one occurrence of the motif TTACGTAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ATF2 [GeneSymbol=ATF2] transcription factor binding site V$CREBP1_01 (v7.4 TRANSFAC).", "CREB_01": "Genes having at least one occurrence of the motif TGACGTMA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CREB1 [GeneSymbol=CREB1] transcription factor binding site V$CREB_01 (v7.4 TRANSFAC).", "CREB_Q2": "Genes having at least one occurrence of the motif NSTGACGTAANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CREB1 [GeneSymbol=CREB1] transcription factor binding site V$CREB_Q2 (v7.4 TRANSFAC).", "CREB_02": "Genes having at least one occurrence of the motif NNGNTGACGTNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CREB1 [GeneSymbol=CREB1] transcription factor binding site V$CREB_02 (v7.4 TRANSFAC).", "CREB_Q2_01": "Genes having at least one occurrence of the motif NNTKACGTCANNNS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CREB1 [GeneSymbol=CREB1] transcription factor binding site V$CREB_Q2_01 (v7.4 TRANSFAC).", "CREB_Q4": "Genes having at least one occurrence of the motif NSTGACGTMANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CREB1 [GeneSymbol=CREB1] transcription factor binding site V$CREB_Q4 (v7.4 TRANSFAC).", "CREB_Q3": "Genes having at least one occurrence of the motif CGTCAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CREB1 [GeneSymbol=CREB1] transcription factor binding site V$CREB_Q3 (v7.4 TRANSFAC).", "CREL_01": "Genes having at least one occurrence of the motif SGGRNTTTCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the REL [GeneSymbol=REL] transcription factor binding site V$CREL_01 (v7.4 TRANSFAC).", "CREB_Q4_01": "Genes having at least one occurrence of the motif CNNTGACGTMA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CREB1 [GeneSymbol=CREB1] transcription factor binding site V$CREB_Q4_01 (v7.4 TRANSFAC).", "CRX_Q4": "Genes having at least one occurrence of the motif YNNNTAATCYCMN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CRX [GeneSymbol=CRX] transcription factor binding site V$CRX_Q4 (v7.4 TRANSFAC).", "CRGAARNNNNCGA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M100 CRGAARNNNNCGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CTCNANGTGNY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M171 CTCNANGTGNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CTAWWWATA_RSRFC4_Q2": "Genes having at least one occurrence of the highly conserved motif M28 CTAWWWATA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEF2A [GeneSymbol=MEF2A] transcription factor binding site V$RSRFC4_Q2 (v7.4 TRANSFAC).", "CTGRYYYNATT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M153 CTGRYYYNATT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CTGCAGY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M101 CTGCAGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CTGYNNCTYTAA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M82 CTGYNNCTYTAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "CYTAGCAAY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M34 CYTAGCAAY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "DR1_Q3": "Genes having at least one occurrence of the motif RGGNCAAAGGTCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR2F2 [GeneSymbol=NR2F2] transcription factor binding site V$DR1_Q3 (v7.4 TRANSFAC).", "DBP_Q6": "Genes having at least one occurrence of the motif AGCAHAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the DBP [GeneSymbol=DBP] transcription factor binding site V$DBP_Q6 (v7.4 TRANSFAC).", "DR3_Q4": "Genes having at least one occurrence of the motif RRTGNMCYTNNTGAMCCNYNT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the VDR [GeneSymbol=VDR] transcription factor binding site V$DR3_Q4 (v7.4 TRANSFAC).", "DR4_Q2": "Genes having at least one occurrence of the motif YGAMCTNNASTRACCYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RXRB [GeneSymbol=RXRB] transcription factor binding site V$DR4_Q2 (v7.4 TRANSFAC).", "E12_Q6": "Genes having at least one occurrence of the motif RRCAGGTGNCV in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF3 [GeneSymbol=TCF3] transcription factor binding site V$E12_Q6 (v7.4 TRANSFAC).", "CTTTGA_LEF1_Q2": "Genes having at least one occurrence of the highly conserved motif M73 CTTTGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the LEF1 [GeneSymbol=LEF1] transcription factor binding site V$LEF1_Q2 (v7.4 TRANSFAC).", "E2A_Q2": "Genes having at least one occurrence of the motif NCACCTGYYNCNKN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF3 [GeneSymbol=TCF3] transcription factor binding site V$E2A_Q2 (v7.4 TRANSFAC).", "CTTTAAR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M29 CTTTAAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "E2F1DP1RB_01": "Genes having at least one occurrence of the motif TTTSGCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1], TFDP1 [GeneSymbol=TFDP1], RB1 [GeneSymbol=RB1] transcription factor binding site V$E2F1DP1RB_01 (v7.4 TRANSFAC).", "E2F1DP1_01": "Genes having at least one occurrence of the motif TTTCSCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1], TFDP1 [GeneSymbol=TFDP1] transcription factor binding site V$E2F1DP1_01 (v7.4 TRANSFAC).", "E2F1_Q3": "Genes having at least one occurrence of the motif NKTSSCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1] transcription factor binding site V$E2F1_Q3 (v7.4 TRANSFAC).", "E2F1DP2_01": "Genes having at least one occurrence of the motif TTTSSCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1], TFDP2 [GeneSymbol=TFDP2] transcription factor binding site V$E2F1DP2_01 (v7.4 TRANSFAC).", "E2F1_Q3_01": "Genes having at least one occurrence of the motif TTGGCGCGRAANNGNM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1] transcription factor binding site V$E2F1_Q3_01 (v7.4 TRANSFAC).", "E2F1_Q4": "Genes having at least one occurrence of the motif NTTSGCGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1] transcription factor binding site V$E2F1_Q4 (v7.4 TRANSFAC).", "E2F1_Q4_01": "Genes having at least one occurrence of the motif TTTSGCGSG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F [GeneSymbol=E2F], TFDP1 [GeneSymbol=TFDP1] transcription factor binding site V$E2F1_Q4_01 (v7.4 TRANSFAC).", "E2F1_Q6": "Genes having at least one occurrence of the motif TTTSGCGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1] transcription factor binding site V$E2F1_Q6 (v7.4 TRANSFAC).", "E2F4DP1_01": "Genes having at least one occurrence of the motif TTTSGCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F4 [GeneSymbol=E2F4], TFDP1 [GeneSymbol=TFDP1] transcription factor binding site V$E2F4DP1_01 (v7.4 TRANSFAC).", "E2F1_Q6_01": "Genes having at least one occurrence of the motif NTTTCGCGCS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1] transcription factor binding site V$E2F1_Q6_01 (v7.4 TRANSFAC).", "E2F_01": "Genes having at least one occurrence of the motif TWSGCGCGAAAAYKR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$E2F_01 (v7.4 TRANSFAC).", "E2F4DP2_01": "Genes having at least one occurrence of the motif TTTCSCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F4 [GeneSymbol=E2F4], TFDP2 [GeneSymbol=TFDP2] transcription factor binding site V$E2F4DP2_01 (v7.4 TRANSFAC).", "E2F_02": "Genes having at least one occurrence of the motif TTTSGCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$E2F_02 (v7.4 TRANSFAC).", "E2F_03": "Genes having at least one occurrence of the motif TTTSGCGCGMNR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$E2F_03 (v7.4 TRANSFAC).", "E2F_Q2": "Genes having at least one occurrence of the motif GGCGSG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F [GeneSymbol=E2F], TFDP1 [GeneSymbol=TFDP1] transcription factor binding site V$E2F_Q2 (v7.4 TRANSFAC).", "E2F_Q3": "Genes having at least one occurrence of the motif TTTCGCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$E2F_Q3 (v7.4 TRANSFAC).", "E2F_Q4": "Genes having at least one occurrence of the motif TTTSGCGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$E2F_Q4 (v7.4 TRANSFAC).", "E2F_Q3_01": "Genes having at least one occurrence of the motif TTTSGCGSG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F [GeneSymbol=E2F], TFDP1 [GeneSymbol=TFDP1] transcription factor binding site V$E2F_Q3_01 (v7.4 TRANSFAC).", "E2F_Q6": "Genes having at least one occurrence of the motif TTTSGCGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$E2F_Q6 (v7.4 TRANSFAC).", "E2F_Q4_01": "Genes having at least one occurrence of the motif NCSCGCSAAAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F [GeneSymbol=E2F], TFDP1 [GeneSymbol=TFDP1] transcription factor binding site V$E2F_Q4_01 (v7.4 TRANSFAC).", "E2F_Q6_01": "Genes having at least one occurrence of the motif NKCGCGCSAAAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F [GeneSymbol=E2F], TFDP1 [GeneSymbol=TFDP1] transcription factor binding site V$E2F_Q6_01 (v7.4 TRANSFAC).", "E47_01": "Genes having at least one occurrence of the motif VSNGCAGGTGKNCNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF3 [GeneSymbol=TCF3] transcription factor binding site V$E47_01 (v7.4 TRANSFAC).", "E4BP4_01": "Genes having at least one occurrence of the motif NRTTAYGTAAYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFIL3 [GeneSymbol=NFIL3] transcription factor binding site V$E4BP4_01 (v7.4 TRANSFAC).", "E47_02": "Genes having at least one occurrence of the motif NNNMRCAGGTGTTMNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF3 [GeneSymbol=TCF3] transcription factor binding site V$E47_02 (v7.4 TRANSFAC).", "EFC_Q6": "Genes having at least one occurrence of the motif MGTTACYAGGCAAM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RFX1 [GeneSymbol=RFX1] transcription factor binding site V$EFC_Q6 (v7.4 TRANSFAC).", "E4F1_Q6": "Genes having at least one occurrence of the motif SYTACGTCAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E4F1 [GeneSymbol=E4F1] transcription factor binding site V$E4F1_Q6 (v7.4 TRANSFAC).", "EGR3_01": "Genes having at least one occurrence of the motif NTGCGTGGGCGK in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EGR3 [GeneSymbol=EGR3] transcription factor binding site V$EGR3_01 (v7.4 TRANSFAC).", "ELK1_01": "Genes having at least one occurrence of the motif NAAACMGGAAGTNCVH in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ELK1 [GeneSymbol=ELK1] transcription factor binding site V$ELK1_01 (v7.4 TRANSFAC).", "EGR_Q6": "Genes having at least one occurrence of the motif GTGGGSGCRRS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EGR1 [GeneSymbol=EGR1], EGR2 [GeneSymbol=EGR2], EGR3 [GeneSymbol=EGR3] transcription factor binding site V$EGR_Q6 (v7.4 TRANSFAC).", "EGR2_01": "Genes having at least one occurrence of the motif NTGCGTRGGCGK in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EGR2 [GeneSymbol=EGR2] transcription factor binding site V$EGR2_01 (v7.4 TRANSFAC).", "EN1_01": "Genes having at least one occurrence of the motif GTANTNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EN1 [GeneSymbol=EN1] transcription factor binding site V$EN1_01 (v7.4 TRANSFAC).", "ELF1_Q6": "Genes having at least one occurrence of the motif RNWMBAGGAART in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ELF1 [GeneSymbol=ELF1] transcription factor binding site V$ELF1_Q6 (v7.4 TRANSFAC).", "EGR1_01": "Genes having at least one occurrence of the motif WTGCGTGGGCGK in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EGR1 [GeneSymbol=EGR1] transcription factor binding site V$EGR1_01 (v7.4 TRANSFAC).", "ELK1_02": "Genes having at least one occurrence of the motif NNNNCCGGAARTNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ELK1 [GeneSymbol=ELK1] transcription factor binding site V$ELK1_02 (v7.4 TRANSFAC).", "ER_Q6": "Genes having at least one occurrence of the motif NNARGNCANNNTGACCYNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ESR1 [GeneSymbol=ESR1] transcription factor binding site V$ER_Q6 (v7.4 TRANSFAC).", "ERR1_Q2": "Genes having at least one occurrence of the motif NNNTNAAGGTCANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ESRRA [GeneSymbol=ESRRA] transcription factor binding site V$ERR1_Q2 (v7.4 TRANSFAC).", "ETF_Q6": "Genes having at least one occurrence of the motif GVGGMGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$ETF_Q6 (v7.4 TRANSFAC).", "ER_Q6_02": "Genes having at least one occurrence of the motif NAGGTCANNNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ESR1 [GeneSymbol=ESR1] transcription factor binding site V$ER_Q6_02 (v7.4 TRANSFAC).", "ER_Q6_01": "Genes having at least one occurrence of the motif KDMAYYNTGACCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ESR1 [GeneSymbol=ESR1] transcription factor binding site V$ER_Q6_01 (v7.4 TRANSFAC).", "EVI1_01": "Genes having at least one occurrence of the motif WGAYAAGATAAGATAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EVI1 [GeneSymbol=EVI1] transcription factor binding site V$EVI1_01 (v7.4 TRANSFAC).", "ETS1_B": "Genes having at least one occurrence of the motif RCAGGAAGTGNNTNS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ETS1 [GeneSymbol=ETS1] transcription factor binding site V$ETS1_B (v7.4 TRANSFAC).", "ETS_Q4": "Genes having at least one occurrence of the motif ANNCACTTCCTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ETS1 [GeneSymbol=ETS1] transcription factor binding site V$ETS_Q4 (v7.4 TRANSFAC).", "EVI1_03": "Genes having at least one occurrence of the motif AGATAAGATAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EVI1 [GeneSymbol=EVI1] transcription factor binding site V$EVI1_03 (v7.4 TRANSFAC).", "EVI1_02": "Genes having at least one occurrence of the motif AGAYAAGATAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EVI1 [GeneSymbol=EVI1] transcription factor binding site V$EVI1_02 (v7.4 TRANSFAC).", "ETS2_B": "Genes having at least one occurrence of the motif KRCAGGAARTRNKT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ETS2 [GeneSymbol=ETS2] transcription factor binding site V$ETS2_B (v7.4 TRANSFAC).", "EVI1_04": "Genes having at least one occurrence of the motif DGATADGAHWAGATA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EVI1 [GeneSymbol=EVI1] transcription factor binding site V$EVI1_04 (v7.4 TRANSFAC).", "EVI1_06": "Genes having at least one occurrence of the motif ACAAGATAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EVI1 [GeneSymbol=EVI1] transcription factor binding site V$EVI1_06 (v7.4 TRANSFAC).", "FOXD3_01": "Genes having at least one occurrence of the motif NAWTGTTTRTTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXD3 [GeneSymbol=FOXD3] transcription factor binding site V$FOXD3_01 (v7.4 TRANSFAC).", "FAC1_01": "Genes having at least one occurrence of the motif NNNCAMAACACRNA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FALZ [GeneSymbol=FALZ] transcription factor binding site V$FAC1_01 (v7.4 TRANSFAC).", "EVI1_05": "Genes having at least one occurrence of the motif AGATAAGATAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EVI1 [GeneSymbol=EVI1] transcription factor binding site V$EVI1_05 (v7.4 TRANSFAC).", "FOXJ2_01": "Genes having at least one occurrence of the motif NNNWAAAYAAAYANNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXJ2 [GeneSymbol=FOXJ2] transcription factor binding site V$FOXJ2_01 (v7.4 TRANSFAC).", "FOXJ2_02": "Genes having at least one occurrence of the motif AYMATAATATTTKN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXJ2 [GeneSymbol=FOXJ2] transcription factor binding site V$FOXJ2_02 (v7.4 TRANSFAC).", "FOXO1_01": "Genes having at least one occurrence of the motif NRWAAACAAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXO1A [GeneSymbol=FOXO1A] transcription factor binding site V$FOXO1_01 (v7.4 TRANSFAC).", "FOXO3_01": "Genes having at least one occurrence of the motif TNNTTGTTTACNTW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXO3A [GeneSymbol=FOXO3A] transcription factor binding site V$FOXO3_01 (v7.4 TRANSFAC).", "FOXO1_02": "Genes having at least one occurrence of the motif GNNTTGTTTACNTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXO1A [GeneSymbol=FOXO1A] transcription factor binding site V$FOXO1_02 (v7.4 TRANSFAC).", "FOXM1_01": "Genes having at least one occurrence of the motif ARATKGAST in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXM1 [GeneSymbol=FOXM1] transcription factor binding site V$FOXM1_01 (v7.4 TRANSFAC).", "FOXO4_01": "Genes having at least one occurrence of the motif RWAAACAANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MLLT7 [GeneSymbol=MLLT7] transcription factor binding site V$FOXO4_01 (v7.4 TRANSFAC).", "FREAC2_01": "Genes having at least one occurrence of the motif NNANNGTAAACAANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXF2 [GeneSymbol=FOXF2] transcription factor binding site V$FREAC2_01 (v7.4 TRANSFAC).", "FOXO4_02": "Genes having at least one occurrence of the motif NNGTTGTTTACNTN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MLLT7 [GeneSymbol=MLLT7] transcription factor binding site V$FOXO4_02 (v7.4 TRANSFAC).", "FOX_Q2": "Genes having at least one occurrence of the motif KATTGTTTRTTTW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXF2 [GeneSymbol=FOXF2] transcription factor binding site V$FOX_Q2 (v7.4 TRANSFAC).", "FREAC4_01": "Genes having at least one occurrence of the motif CTWAWGTAAACANWGN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXD1 [GeneSymbol=FOXD1] transcription factor binding site V$FREAC4_01 (v7.4 TRANSFAC).", "FREAC3_01": "Genes having at least one occurrence of the motif NNNNNGTAAATAAACA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXC1 [GeneSymbol=FOXC1] transcription factor binding site V$FREAC3_01 (v7.4 TRANSFAC).", "FREAC7_01": "Genes having at least one occurrence of the motif WNNANATAAAYANNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXL1 [GeneSymbol=FOXL1] transcription factor binding site V$FREAC7_01 (v7.4 TRANSFAC).", "FXR_IR1_Q6": "Genes having at least one occurrence of the motif GGGTBAATRACCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RXRA [GeneSymbol=RXRA] transcription factor binding site V$FXR_IR1_Q6 (v7.4 TRANSFAC).", "FXR_Q3": "Genes having at least one occurrence of the motif CARGKTSAWTRACC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR1H4 [GeneSymbol=NR1H4] transcription factor binding site V$FXR_Q3 (v7.4 TRANSFAC).", "GAANYNYGACNY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M137 GAANYNYGACNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GABP_B": "Genes having at least one occurrence of the motif VCCGGAAGNGCR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GABPA [GeneSymbol=GABPA], GABPB2 [GeneSymbol=GABPB2] transcription factor binding site V$GABP_B (v7.4 TRANSFAC).", "GATA1_01": "Genes having at least one occurrence of the motif SNNGATNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA1 [GeneSymbol=GATA1] transcription factor binding site V$GATA1_01 (v7.4 TRANSFAC).", "GATA1_02": "Genes having at least one occurrence of the motif NNNNNGATANKGNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA1 [GeneSymbol=GATA1] transcription factor binding site V$GATA1_02 (v7.4 TRANSFAC).", "GATA1_03": "Genes having at least one occurrence of the motif ANGNDGATAANNGN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA1 [GeneSymbol=GATA1] transcription factor binding site V$GATA1_03 (v7.4 TRANSFAC).", "GATA1_04": "Genes having at least one occurrence of the motif NNCWGATARNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA1 [GeneSymbol=GATA1] transcription factor binding site V$GATA1_04 (v7.4 TRANSFAC).", "GATA2_01": "Genes having at least one occurrence of the motif NNNGATRNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA2 [GeneSymbol=GATA2] transcription factor binding site V$GATA2_01 (v7.4 TRANSFAC).", "GATA1_05": "Genes having at least one occurrence of the motif NCWGATAACA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA1 [GeneSymbol=GATA1] transcription factor binding site V$GATA1_05 (v7.4 TRANSFAC).", "GATA3_01": "Genes having at least one occurrence of the motif NNGATARNG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA3 [GeneSymbol=GATA3] transcription factor binding site V$GATA3_01 (v7.4 TRANSFAC).", "GATA4_Q3": "Genes having at least one occurrence of the motif AGATADMAGGGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA4 [GeneSymbol=GATA4] transcription factor binding site V$GATA4_Q3 (v7.4 TRANSFAC).", "GATA6_01": "Genes having at least one occurrence of the motif NNNGATWANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA6 [GeneSymbol=GATA6] transcription factor binding site V$GATA6_01 (v7.4 TRANSFAC).", "GATAAGR_GATA_C": "Genes having at least one occurrence of the highly conserved motif M131 GATAAGR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$GATA_C (v7.4 TRANSFAC).", "GATGKMRGCG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M148 GATGKMRGCG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GATA_C": "Genes having at least one occurrence of the motif NGATAAGNMNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA1 [GeneSymbol=GATA1] transcription factor binding site V$GATA_C (v7.4 TRANSFAC).", "GATA_Q6": "Genes having at least one occurrence of the motif WGATARN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GATA1 [GeneSymbol=GATA1] transcription factor binding site V$GATA_Q6 (v7.4 TRANSFAC).", "GCCNNNWTAAR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M95 GCCNNNWTAAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GCGNNANTTCC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M48 GCGNNANTTCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GATTGGY_NFY_Q6_01": "Genes having at least one occurrence of the highly conserved motif M5 GATTGGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFY_Q6_01 (v7.4 TRANSFAC).", "GCGSCMNTTT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M164 GCGSCMNTTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GCCATNTTG_YY1_Q6": "Genes having at least one occurrence of the highly conserved motif M10 GCCATNTTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the YY1 [GeneSymbol=YY1] transcription factor binding site V$YY1_Q6 (v7.4 TRANSFAC).", "GCANCTGNY_MYOD_Q6": "Genes having at least one occurrence of the highly conserved motif M35 GCANCTGNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYOD1 [GeneSymbol=MYOD1] transcription factor binding site V$MYOD_Q6 (v7.4 TRANSFAC).", "GCNF_01": "Genes having at least one occurrence of the motif NTCAAGKTCAAGKTCANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR6A1 [GeneSymbol=NR6A1] transcription factor binding site V$GNCF_01 (v7.4 TRANSFAC).", "GFI1_01": "Genes having at least one occurrence of the motif NNNNNNNAAATCACWGYNNNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GFI1 [GeneSymbol=GFI1] transcription factor binding site V$GFI1_01 (v7.4 TRANSFAC).", "GCM_Q2": "Genes having at least one occurrence of the motif CNNRCCCGCATD in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GCM1 [GeneSymbol=GCM1] transcription factor binding site V$GCM_Q2 (v7.4 TRANSFAC).", "GCTNWTTGK_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M78 GCTNWTTGK in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGAANCGGAANY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M21 GGAANCGGAANY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGAMTNNNNNTCCY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M74 GGAMTNNNNNTCCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGARNTKYCCA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M163 GGARNTKYCCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGCKCATGS_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M159 GGCKCATGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGCNKCCATNK_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M88 GGCNKCCATNK in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGCNNMSMYNTTG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M123 GGCNNMSMYNTTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGATTA_PITX2_Q2": "Genes having at least one occurrence of the highly conserved motif M93 GGATTA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PITX2 [GeneSymbol=PITX2] transcription factor binding site V$PITX2_Q2 (v7.4 TRANSFAC).", "GGCNRNWCTTYS_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M118 GGCNRNWCTTYS in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGGNNTTTCC_NFKB_Q6_01": "Genes having at least one occurrence of the highly conserved motif M86 GGGNNTTTCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFKB_Q6_01 (v7.4 TRANSFAC).", "GGGNRMNNYCAT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M119 GGGNRMNNYCAT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GRE_C": "Genes having at least one occurrence of the motif GGTACAANNTGTYCTK in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR3C1 [GeneSymbol=NR3C1] transcription factor binding site V$GRE_C (v7.4 TRANSFAC).", "GKCGCNNNNNNNTGAYG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M19 GKCGCNNNNNNNTGAYG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GR_01": "Genes having at least one occurrence of the motif NNNNNNNGKACNNNNTGTTCTNNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR3C1 [GeneSymbol=NR3C1] transcription factor binding site V$GR_01 (v7.4 TRANSFAC).", "GGGYGTGNY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M31 GGGYGTGNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GR_Q6": "Genes having at least one occurrence of the motif NNNNNNCNNTNTGTNCTNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR3C1 [GeneSymbol=NR3C1] transcription factor binding site V$GR_Q6 (v7.4 TRANSFAC).", "GR_Q6_01": "Genes having at least one occurrence of the motif NNTGTYCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR3C1 [GeneSymbol=NR3C1] transcription factor binding site V$GR_Q6_01 (v7.4 TRANSFAC).", "GTCNYYATGR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M98 GTCNYYATGR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GGGTGGRR_PAX4_03": "Genes having at least one occurrence of the highly conserved motif M56 GGGTGGRR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX4 [GeneSymbol=PAX4] transcription factor binding site V$PAX4_03 (v7.4 TRANSFAC).", "GTGGGTGK_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M91 GTGGGTGK in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GTGACGY_E4F1_Q6": "Genes having at least one occurrence of the highly conserved motif M20 GTGACGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E4F1 [GeneSymbol=E4F1] transcription factor binding site V$E4F1_Q6 (v7.4 TRANSFAC).", "GTTGNYNNRGNAAC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M43 GTTGNYNNRGNAAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "GTTNYYNNGGTNA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M89 GTTNYYNNGGTNA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "HEB_Q6": "Genes having at least one occurrence of the motif RCCWGCTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF12 [GeneSymbol=TCF12] transcription factor binding site V$HEB_Q6 (v7.4 TRANSFAC).", "HAND1E47_01": "Genes having at least one occurrence of the motif NNNNGNRTCTGGMWTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HAND1 [GeneSymbol=HAND1] transcription factor binding site V$HAND1E47_01 (v7.4 TRANSFAC).", "GTTRYCATRR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M37 GTTRYCATRR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "HEN1_01": "Genes having at least one occurrence of the motif NNNGGNCNCAGCTGCGNCCCNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NHLH1 [GeneSymbol=NHLH1] transcription factor binding site V$HEN1_01 (v7.4 TRANSFAC).", "HFH1_01": "Genes having at least one occurrence of the motif NATTGTTTATWT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXQ1 [GeneSymbol=FOXQ1] transcription factor binding site V$HFH1_01 (v7.4 TRANSFAC).", "HEN1_02": "Genes having at least one occurrence of the motif NNGGGNCGCAGCTGCGNCCCNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NHLH1 [GeneSymbol=NHLH1] transcription factor binding site V$HEN1_02 (v7.4 TRANSFAC).", "HFH4_01": "Genes having at least one occurrence of the motif AWKTGTTTGTTTA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXJ1 [GeneSymbol=FOXJ1] transcription factor binding site V$HFH4_01 (v7.4 TRANSFAC).", "HFH3_01": "Genes having at least one occurrence of the motif KNNTRTTTRTTTA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXI1 [GeneSymbol=FOXI1] transcription factor binding site V$HFH3_01 (v7.4 TRANSFAC).", "HIF1_Q3": "Genes having at least one occurrence of the motif GNNKACGTGCGGNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HIF1A [GeneSymbol=HIF1A] transcription factor binding site V$HIF1_Q3 (v7.4 TRANSFAC).", "HFH8_01": "Genes having at least one occurrence of the motif NNNTGTTTATNTR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXJ1 [GeneSymbol=FOXJ1] transcription factor binding site V$HFH8_01 (v7.4 TRANSFAC).", "HLF_01": "Genes having at least one occurrence of the motif GTTACRYAAT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HLF [GeneSymbol=HLF] transcription factor binding site V$HLF_01 (v7.4 TRANSFAC).", "HIF1_Q5": "Genes having at least one occurrence of the motif CGTACGTGCNGB in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HIF1A [GeneSymbol=HIF1A] transcription factor binding site V$HIF1_Q5 (v7.4 TRANSFAC).", "HMEF2_Q6": "Genes having at least one occurrence of the motif SKYTAAAAATAACYCH in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$HMEF2_Q6 (v7.4 TRANSFAC).", "HMGIY_Q6": "Genes having at least one occurrence of the motif GGAAAWT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HMGA1 [GeneSymbol=HMGA1] transcription factor binding site V$HMGIY_Q6 (v7.4 TRANSFAC).", "HMX1_01": "Genes having at least one occurrence of the motif CAAGTGCGTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HMX1 [GeneSymbol=HMX1] transcription factor binding site V$HMX1_01 (v7.4 TRANSFAC).", "HNF1_Q6": "Genes having at least one occurrence of the motif WRGTTAATNATTAACNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF1 [GeneSymbol=TCF1] transcription factor binding site V$HNF1_Q6 (v7.4 TRANSFAC).", "HNF1_01": "Genes having at least one occurrence of the motif GGTTAATNWTTAMCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF1 [GeneSymbol=TCF1] transcription factor binding site V$HNF1_01 (v7.4 TRANSFAC).", "HNF1_C": "Genes having at least one occurrence of the motif DGTTAATKAWTNACCAM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF1 [GeneSymbol=TCF1] transcription factor binding site V$HNF1_C (v7.4 TRANSFAC).", "HNF3ALPHA_Q6": "Genes having at least one occurrence of the motif TRTTTGYTYWN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXA1 [GeneSymbol=FOXA1] transcription factor binding site V$HNF3ALPHA_Q6 (v7.4 TRANSFAC).", "HNF3B_01": "Genes having at least one occurrence of the motif KGNANTRTTTRYTTW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXA2 [GeneSymbol=FOXA2] transcription factor binding site V$HNF3B_01 (v7.4 TRANSFAC).", "HNF4_01_B": "Genes having at least one occurrence of the motif NRGGNCAAAGGTCAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HNF4A [GeneSymbol=HNF4A] transcription factor binding site V$HNF4_01_B (v7.4 TRANSFAC).", "HNF3_Q6": "Genes having at least one occurrence of the motif NWRARYAAAYANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXA1 [GeneSymbol=FOXA1] transcription factor binding site V$HNF3_Q6 (v7.4 TRANSFAC).", "HNF4ALPHA_Q6": "Genes having at least one occurrence of the motif VTGAACTTTGMMB in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HNF4A [GeneSymbol=HNF4A] transcription factor binding site V$HNF4ALPHA_Q6 (v7.4 TRANSFAC).", "HNF4_01": "Genes having at least one occurrence of the motif NNNRGGNCAAAGKTCANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HNF4A [GeneSymbol=HNF4A] transcription factor binding site V$HNF4_01 (v7.4 TRANSFAC).", "HOXA3_01": "Genes having at least one occurrence of the motif CNTANNNKN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HOXA3 [GeneSymbol=HOXA3] transcription factor binding site V$HOXA3_01 (v7.4 TRANSFAC).", "HOX13_01": "Genes having at least one occurrence of the motif TGCNHNCWYCCYCATTAKTNNDCNMNHYCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HOXA5 [GeneSymbol=HOXA5] transcription factor binding site V$HOX13_01 (v7.4 TRANSFAC).", "HNF4_Q6": "Genes having at least one occurrence of the motif AARGTCCAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HNF4A [GeneSymbol=HNF4A] transcription factor binding site V$HNF4_Q6 (v7.4 TRANSFAC).", "HNF4_DR1_Q3": "Genes having at least one occurrence of the motif TGAMCTTTGNCCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HNF4A [GeneSymbol=HNF4A] transcription factor binding site V$HNF4_DR1_Q3 (v7.4 TRANSFAC).", "HNF6_Q6": "Genes having at least one occurrence of the motif HWAAATCAATAW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ONECUT1 [GeneSymbol=ONECUT1] transcription factor binding site V$HNF6_Q6 (v7.4 TRANSFAC).", "HOXA4_Q2": "Genes having at least one occurrence of the motif AWAATTRG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HOXA4 [GeneSymbol=HOXA4] transcription factor binding site V$HOXA4_Q2 (v7.4 TRANSFAC).", "HP1SITEFACTOR_Q6": "Genes having at least one occurrence of the motif AATWTTCAACAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$HP1SITEFACTOR_Q6 (v7.4 TRANSFAC).", "HSF1_01": "Genes having at least one occurrence of the motif AGAANRTTCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HSF1 [GeneSymbol=HSF1] transcription factor binding site V$HSF1_01 (v7.4 TRANSFAC).", "HSF_Q6": "Genes having at least one occurrence of the motif TTCCMGARGYTTC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$HSF_Q6 (v7.4 TRANSFAC).", "HSF2_01": "Genes having at least one occurrence of the motif NGAANNWTCK in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HSF2 [GeneSymbol=HSF2] transcription factor binding site V$HSF2_01 (v7.4 TRANSFAC).", "HTF_01": "Genes having at least one occurrence of the motif NNWWWWNGMCACGTCATYNYWNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$HTF_01 (v7.4 TRANSFAC).", "ICSBP_Q6": "Genes having at least one occurrence of the motif RAARTGAAACTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the IRF8 [GeneSymbol=IRF8] transcription factor binding site V$ICSBP_Q6 (v7.4 TRANSFAC).", "IK3_01": "Genes having at least one occurrence of the motif TNYTGGGAATACC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$IK3_01 (v7.4 TRANSFAC).", "IK1_01": "Genes having at least one occurrence of the motif NHNTGGGAATRCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$IK1_01 (v7.4 TRANSFAC).", "IK2_01": "Genes having at least one occurrence of the motif NNNTGGGAWNNC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$IK2_01 (v7.4 TRANSFAC).", "IPF1_Q4": "Genes having at least one occurrence of the motif GHNNTAATGACM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the IPF1 [GeneSymbol=IPF1] transcription factor binding site V$IPF1_Q4 (v7.4 TRANSFAC).", "IRF1_Q6": "Genes having at least one occurrence of the motif TTCACTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the IRF1 [GeneSymbol=IRF1] transcription factor binding site V$IRF1_Q6 (v7.4 TRANSFAC).", "IRF1_01": "Genes having at least one occurrence of the motif SAAAAGYGAAACC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the IRF1 [GeneSymbol=IRF1] transcription factor binding site V$IRF1_01 (v7.4 TRANSFAC).", "IRF2_01": "Genes having at least one occurrence of the motif GAAAAGYGAAASY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the IRF2 [GeneSymbol=IRF2] transcription factor binding site V$IRF2_01 (v7.4 TRANSFAC).", "IRF7_01": "Genes having at least one occurrence of the motif TNSGAAWNCGAAANTNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the IRF7 [GeneSymbol=IRF7] transcription factor binding site V$IRF7_01 (v7.4 TRANSFAC).", "IRF_Q6": "Genes having at least one occurrence of the motif BNCRSTTTCANTTYY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the IRF1 [GeneSymbol=IRF1] transcription factor binding site V$IRF_Q6 (v7.4 TRANSFAC).", "ISRE_01": "Genes having at least one occurrence of the motif CAGTTTCWCTTTYCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT1 [GeneSymbol=STAT1], STAT2 [GeneSymbol=STAT2] transcription factor binding site V$ISRE_01 (v7.4 TRANSFAC).", "KCCGNSWTTT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M157 KCCGNSWTTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "KMCATNNWGGA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M116 KMCATNNWGGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "KRCTCNNNNMANAGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M120 KRCTCNNNNMANAGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "KTGGYRSGAA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M112 KTGGYRSGAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "LEF1_Q6": "Genes having at least one occurrence of the motif SWWCAAAGGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the LEF1 [GeneSymbol=LEF1], TCF1 [GeneSymbol=TCF1] transcription factor binding site V$LEF1_Q6 (v7.4 TRANSFAC).", "LBP1_Q6": "Genes having at least one occurrence of the motif CAGCTGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the UBP1 [GeneSymbol=UBP1] transcription factor binding site V$LBP1_Q6 (v7.4 TRANSFAC).", "LFA1_Q6": "Genes having at least one occurrence of the motif GGGSTCWR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ITGAL [GeneSymbol=ITGAL] transcription factor binding site V$LFA1_Q6 (v7.4 TRANSFAC).", "LEF1_Q2": "Genes having at least one occurrence of the motif TCAAAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the LEF1 [GeneSymbol=LEF1], TCF1 [GeneSymbol=TCF1] transcription factor binding site V$LEF1_Q2 (v7.4 TRANSFAC).", "LMO2COM_01": "Genes having at least one occurrence of the motif CNNCAGGTGBNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the LMO2 [GeneSymbol=LMO2] transcription factor binding site V$LMO2COM_01 (v7.4 TRANSFAC).", "LHX3_01": "Genes having at least one occurrence of the motif AATTAATTAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the LHX3 [GeneSymbol=LHX3] transcription factor binding site V$LHX3_01 (v7.4 TRANSFAC).", "LXR_DR4_Q3": "Genes having at least one occurrence of the motif TGACCGNNAGTRACCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR1H3 [GeneSymbol=NR1H3] transcription factor binding site V$LXR_DR4_Q3 (v7.4 TRANSFAC).", "LXR_Q3": "Genes having at least one occurrence of the motif TGGGGTYACTNNCGGTCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR1H3 [GeneSymbol=NR1H3] transcription factor binding site V$LXR_Q3 (v7.4 TRANSFAC).", "LMO2COM_02": "Genes having at least one occurrence of the motif NMGATANSG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the LMO2 [GeneSymbol=LMO2] transcription factor binding site V$LMO2COM_02 (v7.4 TRANSFAC).", "LYF1_01": "Genes having at least one occurrence of the motif TTTGGGAGR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$LYF1_01 (v7.4 TRANSFAC).", "MAX_01": "Genes having at least one occurrence of the motif NNANCACGTGNTNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MAX [GeneSymbol=MAX] transcription factor binding site V$MAX_01 (v7.4 TRANSFAC).", "MAF_Q6": "Genes having at least one occurrence of the motif TRGRRGGAAGTKKSST in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MAF [GeneSymbol=MAF] transcription factor binding site V$MAF_Q6 (v7.4 TRANSFAC).", "MAZR_01": "Genes having at least one occurrence of the motif NSGGGGGGGGMCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MAZR_01 (v7.4 TRANSFAC).", "MAZ_Q6": "Genes having at least one occurrence of the motif GGGGAGGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MAZ [GeneSymbol=MAZ] transcription factor binding site V$MAZ_Q6 (v7.4 TRANSFAC).", "MEF2_01": "Genes having at least one occurrence of the motif CTCTAAAAATAACYCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MEF2_01 (v7.4 TRANSFAC).", "MCAATNNNNNGCG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M110 MCAATNNNNNGCG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "MEF2_04": "Genes having at least one occurrence of the motif NNTGTTACTAAAAATAGAAMNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MEF2_04 (v7.4 TRANSFAC).", "MEF2_02": "Genes having at least one occurrence of the motif NNNNNNKCTAWAAATAGMNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MEF2_02 (v7.4 TRANSFAC).", "MEF2_03": "Genes having at least one occurrence of the motif NNNNNWKCTAWAAATAGMNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MEF2_03 (v7.4 TRANSFAC).", "MEF2_Q6_01": "Genes having at least one occurrence of the motif RGCTATWTTTAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MEF2_Q6_01 (v7.4 TRANSFAC).", "MEIS1BHOXA9_01": "Genes having at least one occurrence of the motif TGACAGTTTTAYGR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEIS1 [GeneSymbol=MEIS1], HOXA9 [GeneSymbol=HOXA9] transcription factor binding site V$MEIS1BHOXA9_01 (v7.4 TRANSFAC).", "MEIS1AHOXA9_01": "Genes having at least one occurrence of the motif TGACAGKTTTAYGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEIS1 [GeneSymbol=MEIS1], HOXA9 [GeneSymbol=HOXA9] transcription factor binding site V$MEIS1AHOXA9_01 (v7.4 TRANSFAC).", "MEIS1_01": "Genes having at least one occurrence of the motif NNNTGACAGNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEIS1 [GeneSymbol=MEIS1] transcription factor binding site V$MEIS1_01 (v7.4 TRANSFAC).", "MIF1_01": "Genes having at least one occurrence of the motif NNGTTGCWWGGYAACNGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MIF [GeneSymbol=MIF] transcription factor binding site V$MIF1_01 (v7.4 TRANSFAC).", "MMEF2_Q6": "Genes having at least one occurrence of the motif CKSNYTAAAAAWRMCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MMEF2_Q6 (v7.4 TRANSFAC).", "MSX1_01": "Genes having at least one occurrence of the motif CNGTAWNTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MSX1 [GeneSymbol=MSX1] transcription factor binding site V$MSX1_01 (v7.4 TRANSFAC).", "MTF1_Q4": "Genes having at least one occurrence of the motif TBTGCACHCGGCCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MTF1 [GeneSymbol=MTF1] transcription factor binding site V$MTF1_Q4 (v7.4 TRANSFAC).", "MYAATNNNNNNNGGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M138 MYAATNNNNNNNGGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "MYB_Q3": "Genes having at least one occurrence of the motif NNNGNCAGTTN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYB [GeneSymbol=MYB] transcription factor binding site V$MYB_Q3 (v7.4 TRANSFAC).", "MGGAAGTG_GABP_B": "Genes having at least one occurrence of the highly conserved motif M11 MGGAAGTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GABPA [GeneSymbol=GABPA], GABPB2 [GeneSymbol=GABPB2] transcription factor binding site V$GABP_B (v7.4 TRANSFAC).", "MYB_Q6": "Genes having at least one occurrence of the motif NNNAACTGNC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYB [GeneSymbol=MYB] transcription factor binding site V$MYB_Q6 (v7.4 TRANSFAC).", "MYB_Q5_01": "Genes having at least one occurrence of the motif NAACNGNCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYB [GeneSymbol=MYB] transcription factor binding site V$MYB_Q5_01 (v7.4 TRANSFAC).", "MYCMAX_01": "Genes having at least one occurrence of the motif NNACCACGTGGTNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYC [GeneSymbol=MYC], MAX [GeneSymbol=MAX] transcription factor binding site V$MYCMAX_01 (v7.4 TRANSFAC).", "MYCMAX_02": "Genes having at least one occurrence of the motif NANCACGTGNNW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYC [GeneSymbol=MYC], MAX [GeneSymbol=MAX] transcription factor binding site V$MYCMAX_02 (v7.4 TRANSFAC).", "MYCMAX_03": "Genes having at least one occurrence of the motif NNNNNNNCACGTGNNNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYC [GeneSymbol=MYC], MAX [GeneSymbol=MAX] transcription factor binding site V$MYCMAX_03 (v7.4 TRANSFAC).", "MYCMAX_B": "Genes having at least one occurrence of the motif GCCAYGYGSN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYC [GeneSymbol=MYC], MAX [GeneSymbol=MAX] transcription factor binding site V$MYCMAX_B (v7.4 TRANSFAC).", "MYC_Q2": "Genes having at least one occurrence of the motif CACGTGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYC [GeneSymbol=MYC] transcription factor binding site V$MYC_Q2 (v7.4 TRANSFAC).", "MYOD_Q6_01": "Genes having at least one occurrence of the motif CNGNRNCAGGTGNNGNAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYOD1 [GeneSymbol=MYOD1] transcription factor binding site V$MYOD_Q6_01 (v7.4 TRANSFAC).", "MYOD_Q6": "Genes having at least one occurrence of the motif NNCACCTGNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYOD1 [GeneSymbol=MYOD1] transcription factor binding site V$MYOD_Q6 (v7.4 TRANSFAC).", "MYOD_01": "Genes having at least one occurrence of the motif SRACAGGTGKYG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYOD1 [GeneSymbol=MYOD1] transcription factor binding site V$MYOD_01 (v7.4 TRANSFAC).", "MYOGENIN_Q6": "Genes having at least one occurrence of the motif RGCAGSTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYOG [GeneSymbol=MYOG] transcription factor binding site V$MYOGENIN_Q6 (v7.4 TRANSFAC).", "MYOGNF1_01": "Genes having at least one occurrence of the motif CRSCTGTBBNNTTTGGCACBSNGCCARCH in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NF1 [GeneSymbol=NF1] transcription factor binding site V$MYOGNF1_01 (v7.4 TRANSFAC).", "MZF1_01": "Genes having at least one occurrence of the motif NGNGGGGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MZF1_01 (v7.4 TRANSFAC).", "MZF1_02": "Genes having at least one occurrence of the motif KNNNKAGGGGNAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$MZF1_02 (v7.4 TRANSFAC).", "NCX_01": "Genes having at least one occurrence of the motif NNGTAAKTNG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TLX2 [GeneSymbol=TLX2] transcription factor binding site V$NCX_01 (v7.4 TRANSFAC).", "NERF_Q2": "Genes having at least one occurrence of the motif YRNCAGGAAGYRNSTBDS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ELF2 [GeneSymbol=ELF2] transcription factor binding site V$NERF_Q2 (v7.4 TRANSFAC).", "NF1_Q6": "Genes having at least one occurrence of the motif NNTTGGCNNNNNNCCNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NF1 [GeneSymbol=NF1] transcription factor binding site V$NF1_Q6 (v7.4 TRANSFAC).", "NFAT_Q4_01": "Genes having at least one occurrence of the motif NWGGAAANWN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFAT [GeneSymbol=NFAT], NFATC [GeneSymbol=NFATC] transcription factor binding site V$NFAT_Q4_01 (v7.4 TRANSFAC).", "NF1_Q6_01": "Genes having at least one occurrence of the motif NTGGNNNNNNGCCAANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NF1 [GeneSymbol=NF1] transcription factor binding site V$NF1_Q6_01 (v7.4 TRANSFAC).", "NFAT_Q6": "Genes having at least one occurrence of the motif NANWGGAAAANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFAT [GeneSymbol=NFAT], NFATC [GeneSymbol=NFATC] transcription factor binding site V$NFAT_Q6 (v7.4 TRANSFAC).", "NFKAPPAB65_01": "Genes having at least one occurrence of the motif GGGRATTTCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RELA [GeneSymbol=RELA] transcription factor binding site V$NFKAPPAB65_01 (v7.4 TRANSFAC).", "NFE2_01": "Genes having at least one occurrence of the motif TGCTGAGTCAY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFE2 [GeneSymbol=NFE2] transcription factor binding site V$NFE2_01 (v7.4 TRANSFAC).", "NFKAPPAB_01": "Genes having at least one occurrence of the motif GGGAMTTYCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFKB [GeneSymbol=NFKB], RELA [GeneSymbol=RELA] transcription factor binding site V$NFKAPPAB_01 (v7.4 TRANSFAC).", "NFKB_C": "Genes having at least one occurrence of the motif NGGGACTTTCCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFKB_C (v7.4 TRANSFAC).", "NFKB_Q6": "Genes having at least one occurrence of the motif NGGGGAMTTTCCNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFKB_Q6 (v7.4 TRANSFAC).", "NFKB_Q6_01": "Genes having at least one occurrence of the motif NNNNKGGRAANTCCCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFKB_Q6_01 (v7.4 TRANSFAC).", "NFMUE1_Q6": "Genes having at least one occurrence of the motif CGGCCATCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFMUE1_Q6 (v7.4 TRANSFAC).", "NFY_01": "Genes having at least one occurrence of the motif NNNRRCCAATSRGNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFY_01 (v7.4 TRANSFAC).", "NFY_Q6": "Genes having at least one occurrence of the motif TRRCCAATSRN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFY_Q6 (v7.4 TRANSFAC).", "NFY_C": "Genes having at least one occurrence of the motif NCTGATTGGYTASY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFY_C (v7.4 TRANSFAC).", "NFY_Q6_01": "Genes having at least one occurrence of the motif NNNNRRCCAATSR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$NFY_Q6_01 (v7.4 TRANSFAC).", "NGFIC_01": "Genes having at least one occurrence of the motif WTGCGTGGGYGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the EGR4 [GeneSymbol=EGR4] transcription factor binding site V$NGFIC_01 (v7.4 TRANSFAC).", "NKX25_01": "Genes having at least one occurrence of the motif TYAAGTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NKX2-5 [GeneSymbol=NKX2-5] transcription factor binding site V$NKX25_01 (v7.4 TRANSFAC).", "NKX22_01": "Genes having at least one occurrence of the motif TTAAGTRSTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NKX2-2 [GeneSymbol=NKX2-2] transcription factor binding site V$NKX22_01 (v7.4 TRANSFAC).", "NKX25_02": "Genes having at least one occurrence of the motif CWTAATTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NKX2-5 [GeneSymbol=NKX2-5] transcription factor binding site V$NKX25_02 (v7.4 TRANSFAC).", "NKX3A_01": "Genes having at least one occurrence of the motif NWATAAGTATWT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NKX3-1 [GeneSymbol=NKX3-1] transcription factor binding site V$NKX3A_01 (v7.4 TRANSFAC).", "NKX61_01": "Genes having at least one occurrence of the motif TWTTTAATTGGTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NKX6-1 [GeneSymbol=NKX6-1] transcription factor binding site V$NKX61_01 (v7.4 TRANSFAC).", "NKX62_Q2": "Genes having at least one occurrence of the motif NWADTAAWTANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NKX6-2 [GeneSymbol=NKX6-2] transcription factor binding site V$NKX62_Q2 (v7.4 TRANSFAC).", "NRF2_01": "Genes having at least one occurrence of the motif ACCGGAAGNG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GABPB1 [GeneSymbol=GABPB1] transcription factor binding site V$NRF2_01 (v7.4 TRANSFAC).", "NRF2_Q4": "Genes having at least one occurrence of the motif NTGCTGAGTCAKN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFE2L2 [GeneSymbol=NFE2L2] transcription factor binding site V$NRF2_Q4 (v7.4 TRANSFAC).", "NRF1_Q6": "Genes having at least one occurrence of the motif CGCATGCGCR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NRF1 [GeneSymbol=NRF1] transcription factor binding site V$NRF1_Q6 (v7.4 TRANSFAC).", "NRSF_01": "Genes having at least one occurrence of the motif TTCAGCACCACGGACAGMGCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the REST [GeneSymbol=REST] transcription factor binding site V$NRSF_01 (v7.4 TRANSFAC).", "NMYC_01": "Genes having at least one occurrence of the motif NNCCACGTGNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MYCN [GeneSymbol=MYCN] transcription factor binding site V$NMYC_01 (v7.4 TRANSFAC).", "OCT1_01": "Genes having at least one occurrence of the motif NNNNWTATGCAAATNTNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_01 (v7.4 TRANSFAC).", "OCT1_03": "Genes having at least one occurrence of the motif NNNRTAATNANNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_03 (v7.4 TRANSFAC).", "OCT1_02": "Genes having at least one occurrence of the motif NNGAATATKCANNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_02 (v7.4 TRANSFAC).", "OCT1_04": "Genes having at least one occurrence of the motif NNNNNNNWATGCAAATNNNWNNA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_04 (v7.4 TRANSFAC).", "OCT1_05": "Genes having at least one occurrence of the motif MKVATTTGCATATT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_05 (v7.4 TRANSFAC).", "OCT1_06": "Genes having at least one occurrence of the motif CWNAWTKWSATRYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_06 (v7.4 TRANSFAC).", "OCT1_07": "Genes having at least one occurrence of the motif TNTATGBTAATT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_07 (v7.4 TRANSFAC).", "OCT1_Q5_01": "Genes having at least one occurrence of the motif TNATTTGCATW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_Q5_01 (v7.4 TRANSFAC).", "OCT1_B": "Genes having at least one occurrence of the motif TATGCAAATN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_B (v7.4 TRANSFAC).", "OCT_C": "Genes having at least one occurrence of the motif CTNATTTGCATAY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$OCT_C (v7.4 TRANSFAC).", "OCT1_Q6": "Genes having at least one occurrence of the motif NNNNATGCAAATNAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU2F1 [GeneSymbol=POU2F1] transcription factor binding site V$OCT1_Q6 (v7.4 TRANSFAC).", "OLF1_01": "Genes having at least one occurrence of the motif NNCDABTCCCYAGRGARBNKGN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the OLF1 [GeneSymbol=OLF1], OR5I1 [GeneSymbol=OR5I1] transcription factor binding site V$OLF1_01 (v7.4 TRANSFAC).", "OCT_Q6": "Genes having at least one occurrence of the motif TNATTTGCATN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$OCT_Q6 (v7.4 TRANSFAC).", "OSF2_Q6": "Genes having at least one occurrence of the motif ACCACANM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RUNX2 [GeneSymbol=RUNX2] transcription factor binding site V$OSF2_Q6 (v7.4 TRANSFAC).", "P300_01": "Genes having at least one occurrence of the motif NNNGGGAGTNNNNS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PCAF [GeneSymbol=PCAF] transcription factor binding site V$P300_01 (v7.4 TRANSFAC).", "PAX2_01": "Genes having at least one occurrence of the motif NNNNGTCANGNRTKANNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX2 [GeneSymbol=PAX2] transcription factor binding site V$PAX2_01 (v7.4 TRANSFAC).", "P53_DECAMER_Q2": "Genes having at least one occurrence of the motif RGRCAWGNCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TP53 [GeneSymbol=TP53] transcription factor binding site V$P53_DECAMER_Q2 (v7.4 TRANSFAC).", "PAX3_01": "Genes having at least one occurrence of the motif TCGTCACRCTTHM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX3 [GeneSymbol=PAX3] transcription factor binding site V$PAX3_01 (v7.4 TRANSFAC).", "PAX2_02": "Genes having at least one occurrence of the motif NNNAAASNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX2 [GeneSymbol=PAX2] transcription factor binding site V$PAX2_02 (v7.4 TRANSFAC).", "P53_02": "Genes having at least one occurrence of the motif NGRCWTGYCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TP53 [GeneSymbol=TP53] transcription factor binding site V$P53_02 (v7.4 TRANSFAC).", "PAX3_B": "Genes having at least one occurrence of the motif NNNNNNCGTCACGSTYNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX3 [GeneSymbol=PAX3] transcription factor binding site V$PAX3_B (v7.4 TRANSFAC).", "PAX4_01": "Genes having at least one occurrence of the motif NGNVGTCANGCGTGNNSNNYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX4 [GeneSymbol=PAX4] transcription factor binding site V$PAX4_01 (v7.4 TRANSFAC).", "PAX4_02": "Genes having at least one occurrence of the motif NAAWAATTANS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX4 [GeneSymbol=PAX4] transcription factor binding site V$PAX4_02 (v7.4 TRANSFAC).", "PAX4_04": "Genes having at least one occurrence of the motif RAAAAWTANNNNNNNNNNNNNNNYCACNCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX4 [GeneSymbol=PAX4] transcription factor binding site V$PAX4_04 (v7.4 TRANSFAC).", "PAX4_03": "Genes having at least one occurrence of the motif NNNNNYCACCCB in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX4 [GeneSymbol=PAX4] transcription factor binding site V$PAX4_03 (v7.4 TRANSFAC).", "PAX5_02": "Genes having at least one occurrence of the motif RRMSWGANWYCTNRAGCGKRACSRYNSM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX5 [GeneSymbol=PAX5] transcription factor binding site V$PAX5_02 (v7.4 TRANSFAC).", "PAX5_01": "Genes having at least one occurrence of the motif BCNNNRNGCANBGNTGNRTAGCSGCHNB in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX5 [GeneSymbol=PAX5] transcription factor binding site V$PAX5_01 (v7.4 TRANSFAC).", "PAX6_01": "Genes having at least one occurrence of the motif NNNNTTCACGCWTGANTKNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX6 [GeneSymbol=PAX6] transcription factor binding site V$PAX6_01 (v7.4 TRANSFAC).", "PAX8_01": "Genes having at least one occurrence of the motif NNNTNNNGNGTGANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX8 [GeneSymbol=PAX8] transcription factor binding site V$PAX8_01 (v7.4 TRANSFAC).", "PAX8_B": "Genes having at least one occurrence of the motif NCNNTNNTGCRTGANNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX8 [GeneSymbol=PAX8] transcription factor binding site V$PAX8_B (v7.4 TRANSFAC).", "PBX1_02": "Genes having at least one occurrence of the motif NNCATCAATCAANNW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PBX1 [GeneSymbol=PBX1] transcription factor binding site V$PBX1_02 (v7.4 TRANSFAC).", "PBX1_01": "Genes having at least one occurrence of the motif ANCAATCAW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PBX1 [GeneSymbol=PBX1] transcription factor binding site V$PBX1_01 (v7.4 TRANSFAC).", "PAX_Q6": "Genes having at least one occurrence of the motif CTGGAACTMAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PAX2 [GeneSymbol=PAX2] transcription factor binding site V$PAX_Q6 (v7.4 TRANSFAC).", "PEA3_Q6": "Genes having at least one occurrence of the motif ACWTCCK in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ETV4 [GeneSymbol=ETV4] transcription factor binding site V$PEA3_Q6 (v7.4 TRANSFAC).", "PIT1_Q6": "Genes having at least one occurrence of the motif NMTTCATAAWTATWNMNA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU1F1 [GeneSymbol=POU1F1] transcription factor binding site V$PIT1_Q6 (v7.4 TRANSFAC).", "PITX2_Q2": "Genes having at least one occurrence of the motif WNTAATCCCAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PITX2 [GeneSymbol=PITX2] transcription factor binding site V$PITX2_Q2 (v7.4 TRANSFAC).", "POU1F1_Q6": "Genes having at least one occurrence of the motif ATGAATAAWT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU1F1 [GeneSymbol=POU1F1] transcription factor binding site V$POU1F1_Q6 (v7.4 TRANSFAC).", "POU3F2_01": "Genes having at least one occurrence of the motif ATGMATWWATTCAT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU3F2 [GeneSymbol=POU3F2] transcription factor binding site V$POU3F2_01 (v7.4 TRANSFAC).", "POU3F2_02": "Genes having at least one occurrence of the motif TTATGYTAAT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU3F2 [GeneSymbol=POU3F2] transcription factor binding site V$POU3F2_02 (v7.4 TRANSFAC).", "PPARA_01": "Genes having at least one occurrence of the motif CARAACTAGGNCAAAGGTCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PPARA [GeneSymbol=PPARA] transcription factor binding site V$PPARA_01 (v7.4 TRANSFAC).", "POU6F1_01": "Genes having at least one occurrence of the motif GCATAAWTTAT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU6F1 [GeneSymbol=POU6F1] transcription factor binding site V$POU6F1_01 (v7.4 TRANSFAC).", "PPARA_02": "Genes having at least one occurrence of the motif NNRGGTCATWGGGGTSANG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PPARA [GeneSymbol=PPARA] transcription factor binding site V$PPARA_02 (v7.4 TRANSFAC).", "PPARG_01": "Genes having at least one occurrence of the motif NNWGRGGTCAAAGGTCANNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PPARG [GeneSymbol=PPARG] transcription factor binding site V$PPARG_01 (v7.4 TRANSFAC).", "PR_01": "Genes having at least one occurrence of the motif NNNNNNGGNACRNNNTGTTCTNNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PGR [GeneSymbol=PGR] transcription factor binding site V$PR_01 (v7.4 TRANSFAC).", "PR_02": "Genes having at least one occurrence of the motif NNNNNNRGNACNNKNTGTTCTNNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PGR [GeneSymbol=PGR] transcription factor binding site V$PR_02 (v7.4 TRANSFAC).", "PPAR_DR1_Q2": "Genes having at least one occurrence of the motif TGACCTTTGNCCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PPARA [GeneSymbol=PPARA] transcription factor binding site V$PPAR_DR1_Q2 (v7.4 TRANSFAC).", "PR_Q2": "Genes having at least one occurrence of the motif NWNAGRACAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR3C1 [GeneSymbol=NR3C1] transcription factor binding site V$PR_Q2 (v7.4 TRANSFAC).", "PTF1BETA_Q6": "Genes having at least one occurrence of the motif GRGAAAMBBWCAGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PTF1A [GeneSymbol=PTF1A] transcription factor binding site V$PTF1BETA_Q6 (v7.4 TRANSFAC).", "PU1_Q6": "Genes having at least one occurrence of the motif WGAGGAAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SPI1 [GeneSymbol=SPI1] transcription factor binding site V$PU1_Q6 (v7.4 TRANSFAC).", "RAAGNYNNCTTY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M125 RAAGNYNNCTTY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "PXR_Q2": "Genes having at least one occurrence of the motif RRGGTYANTRNM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NR1H4 [GeneSymbol=NR1H4] transcription factor binding site V$PXR_Q2 (v7.4 TRANSFAC).", "RACTNNRTTTNC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M66 RACTNNRTTTNC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RACCACAR_AML_Q6": "Genes having at least one occurrence of the highly conserved motif M111 RACCACAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RUNX1 [GeneSymbol=RUNX1] transcription factor binding site V$AML_Q6 (v7.4 TRANSFAC).", "RFX1_01": "Genes having at least one occurrence of the motif NNGTNRCNWRGYAACNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RFX1 [GeneSymbol=RFX1] transcription factor binding site V$RFX1_01 (v7.4 TRANSFAC).", "RFX1_02": "Genes having at least one occurrence of the motif NNGTNRCNATRGYAACNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RFX1 [GeneSymbol=RFX1] transcription factor binding site V$RFX1_02 (v7.4 TRANSFAC).", "RCGCANGCGY_NRF1_Q6": "Genes having at least one occurrence of the highly conserved motif M1 RCGCANGCGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NRF1 [GeneSymbol=NRF1] transcription factor binding site V$NRF1_Q6 (v7.4 TRANSFAC).", "RGTTAMWNATT_HNF1_01": "Genes having at least one occurrence of the highly conserved motif M84 RGTTAMWNATT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF1 [GeneSymbol=TCF1] transcription factor binding site V$HNF1_01 (v7.4 TRANSFAC).", "ROAZ_01": "Genes having at least one occurrence of the motif GCACCCAWGGGTGM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZNF423 [GeneSymbol=ZNF423] transcription factor binding site V$ROAZ_01 (v7.4 TRANSFAC).", "RGAGGAARY_PU1_Q6": "Genes having at least one occurrence of the highly conserved motif M50 RGAGGAARY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SPI1 [GeneSymbol=SPI1] transcription factor binding site V$PU1_Q6 (v7.4 TRANSFAC).", "RNCTGNYNRNCTGNY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M154 RNCTGNYNRNCTGNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RGAANNTTC_HSF1_01": "Genes having at least one occurrence of the highly conserved motif M68 RGAANNTTC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HSF1 [GeneSymbol=HSF1] transcription factor binding site V$HSF1_01 (v7.4 TRANSFAC).", "RNTCANNRNNYNATTW_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M122 RNTCANNRNNYNATTW in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RNGTGGGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M140 RNGTGGGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RORA1_01": "Genes having at least one occurrence of the motif NWAWNNAGGTCAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RORA [GeneSymbol=RORA] transcription factor binding site V$RORA1_01 (v7.4 TRANSFAC).", "RP58_01": "Genes having at least one occurrence of the motif NNAACATCTGGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZNF238 [GeneSymbol=ZNF238] transcription factor binding site V$RP58_01 (v7.4 TRANSFAC).", "RRAGTTGT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M129 RRAGTTGT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RRCCGTTA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M146 RRCCGTTA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RSRFC4_Q2": "Genes having at least one occurrence of the motif ANKCTAWAAATAGMHNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEF2A [GeneSymbol=MEF2A] transcription factor binding site V$RSRFC4_Q2 (v7.4 TRANSFAC).", "RSRFC4_01": "Genes having at least one occurrence of the motif RNKCTATTTWTAGMWN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEF2A [GeneSymbol=MEF2A] transcription factor binding site V$RSRFC4_01 (v7.4 TRANSFAC).", "RREB1_01": "Genes having at least one occurrence of the motif CCCCAAACMMCCCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RREB1 [GeneSymbol=RREB1] transcription factor binding site V$RREB1_01 (v7.4 TRANSFAC).", "RORA2_01": "Genes having at least one occurrence of the motif NWAWNTAGGTCAN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the RORA [GeneSymbol=RORA] transcription factor binding site V$RORA2_01 (v7.4 TRANSFAC).", "RTTTNNNYTGGM_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M107 RTTTNNNYTGGM in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RTAAACA_FREAC2_01": "Genes having at least one occurrence of the highly conserved motif M36 RTAAACA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXF2 [GeneSymbol=FOXF2] transcription factor binding site V$FREAC2_01 (v7.4 TRANSFAC).", "RYAAAKNNNNNNTTGW_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M151 RYAAAKNNNNNNTTGW in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RYCACNNRNNRNCAG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M128 RYCACNNRNNRNCAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RYTAAWNNNTGAY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M133 RYTAAWNNNTGAY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "RYTGCNNRGNAAC_MIF1_01": "Genes having at least one occurrence of the highly conserved motif M53 RYTGCNNRGNAAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MIF [GeneSymbol=MIF] transcription factor binding site V$MIF1_01 (v7.4 TRANSFAC).", "SEF1_C": "Genes having at least one occurrence of the motif AACACGGATATCTGTGGTY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$SEF1_C (v7.4 TRANSFAC).", "RYTGCNWTGGNR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M87 RYTGCNWTGGNR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "S8_01": "Genes having at least one occurrence of the motif WNNANYYAATTANCNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the PRRX2 [GeneSymbol=PRRX2] transcription factor binding site V$S8_01 (v7.4 TRANSFAC).", "SF1_Q6": "Genes having at least one occurrence of the motif TGRCCTTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SF1 [GeneSymbol=SF1] transcription factor binding site V$SF1_Q6 (v7.4 TRANSFAC).", "RYTTCCTG_ETS2_B": "Genes having at least one occurrence of the highly conserved motif M16 RYTTCCTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ETS2 [GeneSymbol=ETS2] transcription factor binding site V$ETS2_B (v7.4 TRANSFAC).", "SCGGAAGY_ELK1_02": "Genes having at least one occurrence of the highly conserved motif M3 SCGGAAGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ELK1 [GeneSymbol=ELK1] transcription factor binding site V$ELK1_02 (v7.4 TRANSFAC).", "SGCGSSAAA_E2F1DP2_01": "Genes having at least one occurrence of the highly conserved motif M69 SGCGSSAAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the E2F1 [GeneSymbol=E2F1], TFDP1 [GeneSymbol=TFDP1], RB1 [GeneSymbol=RB1] transcription factor binding site V$E2F1DP2_01 (v7.4 TRANSFAC).", "SMAD3_Q6": "Genes having at least one occurrence of the motif TGTCTGTCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SMAD3 [GeneSymbol=SMAD3] transcription factor binding site V$SMAD3_Q6 (v7.4 TRANSFAC).", "SMAD_Q6": "Genes having at least one occurrence of the motif AGACNBCNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SMAD1 [GeneSymbol=SMAD1] transcription factor binding site V$SMAD_Q6 (v7.4 TRANSFAC).", "SMAD4_Q6": "Genes having at least one occurrence of the motif GKSRKKCAGMCANCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SMAD4 [GeneSymbol=SMAD4] transcription factor binding site V$SMAD4_Q6 (v7.4 TRANSFAC).", "SNACANNNYSYAGA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M80 SNACANNNYSYAGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "SMTTTTGT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M62 SMTTTTGT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "SOX9_B1": "Genes having at least one occurrence of the motif NNNNAACAATRGNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SOX9 [GeneSymbol=SOX9] transcription factor binding site V$SOX9_B1 (v7.4 TRANSFAC).", "SOX5_01": "Genes having at least one occurrence of the motif NNAACAATNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SOX5 [GeneSymbol=SOX5] transcription factor binding site V$SOX5_01 (v7.4 TRANSFAC).", "SP1_01": "Genes having at least one occurrence of the motif GGGGCGGGGT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SP1 [GeneSymbol=SP1] transcription factor binding site V$SP1_01 (v7.4 TRANSFAC).", "SP1_Q2_01": "Genes having at least one occurrence of the motif CCCCGCCCCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SP1 [GeneSymbol=SP1] transcription factor binding site V$SP1_Q2_01 (v7.4 TRANSFAC).", "SP1_Q4_01": "Genes having at least one occurrence of the motif NNGGGGCGGGGNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SP1 [GeneSymbol=SP1] transcription factor binding site V$SP1_Q4_01 (v7.4 TRANSFAC).", "SP1_Q6": "Genes having at least one occurrence of the motif NGGGGGCGGGGYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SP1 [GeneSymbol=SP1] transcription factor binding site V$SP1_Q6 (v7.4 TRANSFAC).", "SP3_Q3": "Genes having at least one occurrence of the motif ASMCTTGGGSRGGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SP3 [GeneSymbol=SP3] transcription factor binding site V$SP3_Q3 (v7.4 TRANSFAC).", "SP1_Q6_01": "Genes having at least one occurrence of the motif GGGGCGGGGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SP1 [GeneSymbol=SP1] transcription factor binding site V$SP1_Q6_01 (v7.4 TRANSFAC).", "SPZ1_01": "Genes having at least one occurrence of the motif DNNGGRGGGWWNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SPZ1 [GeneSymbol=SPZ1] transcription factor binding site V$SPZ1_01 (v7.4 TRANSFAC).", "SREBP1_02": "Genes having at least one occurrence of the motif KATCACCCCAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SREBF1 [GeneSymbol=SREBF1] transcription factor binding site V$SREBP1_02 (v7.4 TRANSFAC).", "SREBP1_01": "Genes having at least one occurrence of the motif NATCACGTGAY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SREBF1 [GeneSymbol=SREBF1] transcription factor binding site V$SREBP1_01 (v7.4 TRANSFAC).", "SRF_01": "Genes having at least one occurrence of the motif ATGCCCATATATGGWNNT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SRF [GeneSymbol=SRF] transcription factor binding site V$SRF_01 (v7.4 TRANSFAC).", "SREBP1_Q6": "Genes having at least one occurrence of the motif CACSCCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SREBF1 [GeneSymbol=SREBF1] transcription factor binding site V$SREBP1_Q6 (v7.4 TRANSFAC).", "SREBP_Q3": "Genes having at least one occurrence of the motif VNNVTCACCCYA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$SREBP_Q3 (v7.4 TRANSFAC).", "SRF_Q4": "Genes having at least one occurrence of the motif SCCAWATAWGGMNMNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SRF [GeneSymbol=SRF] transcription factor binding site V$SRF_Q4 (v7.4 TRANSFAC).", "SRF_C": "Genes having at least one occurrence of the motif DCCWTATATGGNCWN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SRF [GeneSymbol=SRF] transcription factor binding site V$SRF_C (v7.4 TRANSFAC).", "SRF_Q6": "Genes having at least one occurrence of the motif GNCCAWATAWGGMN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SRF [GeneSymbol=SRF] transcription factor binding site V$SRF_Q6 (v7.4 TRANSFAC).", "SRF_Q5_01": "Genes having at least one occurrence of the motif CCAWATAWGGMNMNG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SRF [GeneSymbol=SRF] transcription factor binding site V$SRF_Q5_01 (v7.4 TRANSFAC).", "SRY_01": "Genes having at least one occurrence of the motif AAACWAM in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SRY [GeneSymbol=SRY] transcription factor binding site V$SRY_01 (v7.4 TRANSFAC).", "SRY_02": "Genes having at least one occurrence of the motif NWWAACAAWANN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SRY [GeneSymbol=SRY] transcription factor binding site V$SRY_02 (v7.4 TRANSFAC).", "STAT1_01": "Genes having at least one occurrence of the motif NNNSANTTCCGGGAANTGNSN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT1 [GeneSymbol=STAT1] transcription factor binding site V$STAT1_01 (v7.4 TRANSFAC).", "STAT3_01": "Genes having at least one occurrence of the motif NGNNATTTCCSGGAARTGNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT3 [GeneSymbol=STAT3] transcription factor binding site V$STAT3_01 (v7.4 TRANSFAC).", "STAT1_02": "Genes having at least one occurrence of the motif CANTTCCS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT1 [GeneSymbol=STAT1] transcription factor binding site V$STAT1_02 (v7.4 TRANSFAC).", "STAT1_03": "Genes having at least one occurrence of the motif NNTTTCCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT1 [GeneSymbol=STAT1] transcription factor binding site V$STAT1_03 (v7.4 TRANSFAC).", "STAT3_02": "Genes having at least one occurrence of the motif NNNTTCCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT3 [GeneSymbol=STAT3] transcription factor binding site V$STAT3_02 (v7.4 TRANSFAC).", "STAT4_01": "Genes having at least one occurrence of the motif SNWTTCNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT4 [GeneSymbol=STAT4] transcription factor binding site V$STAT4_01 (v7.4 TRANSFAC).", "STAT5A_02": "Genes having at least one occurrence of the motif TTCCNRGAANNNNNNTTCCNNGRR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT5A [GeneSymbol=STAT5A] transcription factor binding site V$STAT5A_02 (v7.4 TRANSFAC).", "STAT5A_01": "Genes having at least one occurrence of the motif NAWTTCYNGGAANYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT5A [GeneSymbol=STAT5A] transcription factor binding site V$STAT5A_01 (v7.4 TRANSFAC).", "STAT5A_03": "Genes having at least one occurrence of the motif NAWTTCYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT5A [GeneSymbol=STAT5A] transcription factor binding site V$STAT5A_03 (v7.4 TRANSFAC).", "STAT5A_04": "Genes having at least one occurrence of the motif NNNTTCYN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT5A [GeneSymbol=STAT5A] transcription factor binding site V$STAT5A_04 (v7.4 TRANSFAC).", "STAT6_01": "Genes having at least one occurrence of the motif NAWTTCCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT6 [GeneSymbol=STAT6] transcription factor binding site V$STAT6_01 (v7.4 TRANSFAC).", "STAT5B_01": "Genes having at least one occurrence of the motif NAWTTCYNGGAAWTN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT5B [GeneSymbol=STAT5B] transcription factor binding site V$STAT5B_01 (v7.4 TRANSFAC).", "STAT6_02": "Genes having at least one occurrence of the motif NNYTTCCY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT6 [GeneSymbol=STAT6] transcription factor binding site V$STAT6_02 (v7.4 TRANSFAC).", "STAT_01": "Genes having at least one occurrence of the motif TTCCCGKAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$STAT_01 (v7.4 TRANSFAC).", "STAT_Q6": "Genes having at least one occurrence of the motif NNNNNTTCTKGGA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$STAT_Q6 (v7.4 TRANSFAC).", "STTTCRNTTT_IRF_Q6": "Genes having at least one occurrence of the highly conserved motif M85 STTTCRNTTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$IRF_Q6 (v7.4 TRANSFAC).", "T3R_Q6": "Genes having at least one occurrence of the motif MNTGWCCTN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$T3R_Q6 (v7.4 TRANSFAC).", "TAANNYSGCG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M162 TAANNYSGCG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TAAYNRNNTCC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M136 TAAYNRNNTCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "SYATTGTG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M71 SYATTGTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TAAWWATAG_RSRFC4_Q2": "Genes having at least one occurrence of the highly conserved motif M54 TAAWWATAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEF2A [GeneSymbol=MEF2A] transcription factor binding site V$RSRFC4_Q2 (v7.4 TRANSFAC).", "TAL1BETAE47_01": "Genes having at least one occurrence of the motif NNNAACAGATGKTNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TAL1 [GeneSymbol=TAL1], TCF3 [GeneSymbol=TCF3] transcription factor binding site V$TAL1BETAE47_01 (v7.4 TRANSFAC).", "TAATTA_CHX10_01": "Genes having at least one occurrence of the highly conserved motif M23 TAATTA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the VSX1 [GeneSymbol=VSX1] transcription factor binding site V$CHX10_01 (v7.4 TRANSFAC).", "TAL1BETAITF2_01": "Genes having at least one occurrence of the motif NNNAACAGATGKTNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TAL1 [GeneSymbol=TAL1], TCF4 [GeneSymbol=TCF4] transcription factor binding site V$TAL1BETAITF2_01 (v7.4 TRANSFAC).", "TAL1ALPHAE47_01": "Genes having at least one occurrence of the motif NNNAACAGATGKTNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TAL1 [GeneSymbol=TAL1], TCF3 [GeneSymbol=TCF3] transcription factor binding site V$TAL1ALPHAE47_01 (v7.4 TRANSFAC).", "TAXCREB_02": "Genes having at least one occurrence of the motif RTGACGCATAYCCCC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$TAXCREB_02 (v7.4 TRANSFAC).", "TATA_01": "Genes having at least one occurrence of the motif STATAAAWRNNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TAF [GeneSymbol=TAF], TATA [GeneSymbol=TATA] transcription factor binding site V$TATA_01 (v7.4 TRANSFAC).", "TAXCREB_01": "Genes having at least one occurrence of the motif GGGGGTTGACGYANA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$TAXCREB_01 (v7.4 TRANSFAC).", "TATA_C": "Genes having at least one occurrence of the motif NCTATAAAAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TAF [GeneSymbol=TAF], TATA [GeneSymbol=TATA] transcription factor binding site V$TATA_C (v7.4 TRANSFAC).", "TATAAA_TATA_01": "Genes having at least one occurrence of the highly conserved motif M51 TATAAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TAF [GeneSymbol=TAF], TATA [GeneSymbol=TATA] transcription factor binding site V$TATA_01 (v7.4 TRANSFAC).", "TBP_01": "Genes having at least one occurrence of the motif TATAAATW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TBP [GeneSymbol=TBP] transcription factor binding site V$TBP_01 (v7.4 TRANSFAC).", "TCCCRNNRTGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M39 TCCCRNNRTGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TCF11MAFG_01": "Genes having at least one occurrence of the motif NNNNNATGACTCAGCANTTNNG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF11 [GeneSymbol=TCF11], MAFG [GeneSymbol=MAFG] transcription factor binding site V$TCF11MAFG_01 (v7.4 TRANSFAC).", "TCANNTGAY_SREBP1_01": "Genes having at least one occurrence of the highly conserved motif M18 TCANNTGAY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SREBF1 [GeneSymbol=SREBF1] transcription factor binding site V$SREBP1_01 (v7.4 TRANSFAC).", "TCCATTKW_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M132 TCCATTKW in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TCF11_01": "Genes having at least one occurrence of the motif GTCATNNWNNNNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFE2L1 [GeneSymbol=NFE2L1] transcription factor binding site V$TCF11_01 (v7.4 TRANSFAC).", "TCF4_Q5": "Genes having at least one occurrence of the motif SCTTTGAW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF4 [GeneSymbol=TCF4] transcription factor binding site V$TCF4_Q5 (v7.4 TRANSFAC).", "TCF1P_Q6": "Genes having at least one occurrence of the motif GKCRGKTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TCF1 [GeneSymbol=TCF1] transcription factor binding site V$TCF1P_Q6 (v7.4 TRANSFAC).", "TEF_Q6": "Genes having at least one occurrence of the motif ATGTTWAYATAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TEF [GeneSymbol=TEF] transcription factor binding site V$TEF_Q6 (v7.4 TRANSFAC).", "TEF1_Q6": "Genes having at least one occurrence of the motif GRRATG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$TEF1_Q6 (v7.4 TRANSFAC).", "TEL2_Q6": "Genes having at least one occurrence of the motif YTACTTCCTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ETV7 [GeneSymbol=ETV7] transcription factor binding site V$TEL2_Q6 (v7.4 TRANSFAC).", "TFIIA_Q6": "Genes having at least one occurrence of the motif TMTRWRAGGRSS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GTF2A1 [GeneSymbol=GTF2A1], GTF2A2 [GeneSymbol=GTF2A2] transcription factor binding site V$TFIIA_Q6 (v7.4 TRANSFAC).", "TFIII_Q6": "Genes having at least one occurrence of the motif RGAGGKAGG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GTF2A1 [GeneSymbol=GTF2A1], GTF2A2 [GeneSymbol=GTF2A2] transcription factor binding site V$TFIII_Q6 (v7.4 TRANSFAC).", "TGACCTTG_SF1_Q6": "Genes having at least one occurrence of the highly conserved motif M38 TGACCTTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the SF1 [GeneSymbol=SF1] transcription factor binding site V$SF1_Q6 (v7.4 TRANSFAC).", "TGACATY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M42 TGACATY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TGACGTCA_ATF3_Q6": "Genes having at least one occurrence of the highly conserved motif M14 TGACGTCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ATF3 [GeneSymbol=ATF3] transcription factor binding site V$ATF3_Q6 (v7.4 TRANSFAC).", "TGACCTY_ERR1_Q2": "Genes having at least one occurrence of the highly conserved motif M25 TGACCTY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ESRRA [GeneSymbol=ESRRA] transcription factor binding site V$ERR1_Q2 (v7.4 TRANSFAC).", "TGANNYRGCA_TCF11MAFG_01": "Genes having at least one occurrence of the highly conserved motif M67 TGANNYRGCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFE2L1 [GeneSymbol=NFE2L1], MAFG [GeneSymbol=MAFG] transcription factor binding site V$TCF11MAFG_01 (v7.4 TRANSFAC).", "TGACAGNY_MEIS1_01": "Genes having at least one occurrence of the highly conserved motif M41 TGACAGNY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEIS1 [GeneSymbol=MEIS1] transcription factor binding site V$MEIS1_01 (v7.4 TRANSFAC).", "TGASTMAGC_NFE2_01": "Genes having at least one occurrence of the highly conserved motif M32 TGASTMAGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFE2 [GeneSymbol=NFE2] transcription factor binding site V$NFE2_01 (v7.4 TRANSFAC).", "TGANTCA_AP1_C": "Genes having at least one occurrence of the highly conserved motif M7 TGANTCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the JUN [GeneSymbol=JUN] transcription factor binding site V$AP1_C (v7.4 TRANSFAC).", "TGATTTRY_GFI1_01": "Genes having at least one occurrence of the highly conserved motif M94 TGATTTRY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the GFI1 [GeneSymbol=GFI1] transcription factor binding site V$GFI1_01 (v7.4 TRANSFAC).", "TGAYRTCA_ATF3_Q6": "Genes having at least one occurrence of the highly conserved motif M9 TGAYRTCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ATF3 [GeneSymbol=ATF3] transcription factor binding site V$ATF3_Q6 (v7.4 TRANSFAC).", "TGCCAAR_NF1_Q6": "Genes having at least one occurrence of the highly conserved motif M47 TGCCAAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NF1 [GeneSymbol=NF1] transcription factor binding site V$NF1_Q6 (v7.4 TRANSFAC).", "TGCTGAY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M92 TGCTGAY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TGGNNNNNNKCCAR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M27 TGGNNNNNNKCCAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TGIF_01": "Genes having at least one occurrence of the motif AGCTGTCANNA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TGIF [GeneSymbol=TGIF] transcription factor binding site V$TGIF_01 (v7.4 TRANSFAC).", "TGCGCANK_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M22 TGCGCANK in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TITF1_Q3": "Genes having at least one occurrence of the motif WCTCAAGTGT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TITF1 [GeneSymbol=TITF1] transcription factor binding site V$TITF1_Q3 (v7.4 TRANSFAC).", "TGTYNNNNNRGCARM_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M117 TGTYNNNNNRGCARM in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TGTTTGY_HNF3_Q6": "Genes having at least one occurrence of the highly conserved motif M83 TGTTTGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXA1 [GeneSymbol=FOXA1] transcription factor binding site V$HNF3_Q6 (v7.4 TRANSFAC).", "TGGAAA_NFAT_Q4_01": "Genes having at least one occurrence of the highly conserved motif M55 TGGAAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFAT [GeneSymbol=NFAT], NFATC [GeneSymbol=NFATC] transcription factor binding site V$NFAT_Q4_01 (v7.4 TRANSFAC).", "TMTCGCGANR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M8 TMTCGCGANR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TNCATNTCCYR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M75 TNCATNTCCYR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TTANWNANTGGM_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M161 TTANWNANTGGM in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TST1_01": "Genes having at least one occurrence of the motif NNKGAATTAVAVTDN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the POU3F1 [GeneSymbol=POU3F1] transcription factor binding site V$TST1_01 (v7.4 TRANSFAC).", "TTANTCA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M64 TTANTCA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TTAYRTAA_E4BP4_01": "Genes having at least one occurrence of the highly conserved motif M26 TTAYRTAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the NFIL3 [GeneSymbol=NFIL3] transcription factor binding site V$E4BP4_01 (v7.4 TRANSFAC).", "TTCNRGNNNNTTC_HSF_Q6": "Genes having at least one occurrence of the highly conserved motif M141 TTCNRGNNNNTTC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$HSF_Q6 (v7.4 TRANSFAC).", "TTF1_Q6": "Genes having at least one occurrence of the motif NNNNCAAGNRNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TITF1 [GeneSymbol=TITF1] transcription factor binding site V$TTF1_Q6 (v7.4 TRANSFAC).", "TTCYNRGAA_STAT5B_01": "Genes having at least one occurrence of the highly conserved motif M40 TTCYNRGAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the STAT5B [GeneSymbol=STAT5B] transcription factor binding site V$STAT5B_01 (v7.4 TRANSFAC).", "TTCYRGAA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M72 TTCYRGAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "TTGCWCAAY_CEBPB_02": "Genes having at least one occurrence of the highly conserved motif M172 TTGCWCAAY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the CEBPB [GeneSymbol=CEBPB] transcription factor binding site V$CEBPB_02 (v7.4 TRANSFAC).", "TTTNNANAGCYR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M169 TTTNNANAGCYR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "USF2_Q6": "Genes having at least one occurrence of the motif CASGYG in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$USF2_Q6 (v7.4 TRANSFAC).", "USF_01": "Genes having at least one occurrence of the motif NNRYCACGTGRYNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$USF_01 (v7.4 TRANSFAC).", "USF_C": "Genes having at least one occurrence of the motif NCACGTGN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$USF_C (v7.4 TRANSFAC).", "USF_02": "Genes having at least one occurrence of the motif NNRNCACGTGNYNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$USF_02 (v7.4 TRANSFAC).", "USF_Q6": "Genes having at least one occurrence of the motif GYCACGTGNC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$USF_Q6 (v7.4 TRANSFAC).", "USF_Q6_01": "Genes having at least one occurrence of the motif NRCCACGTGASN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$USF_Q6_01 (v7.4 TRANSFAC).", "VDR_Q3": "Genes having at least one occurrence of the motif GGGKNARNRRGGWSA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the VDR [GeneSymbol=VDR] transcription factor binding site V$VDR_Q3 (v7.4 TRANSFAC).", "VDR_Q6": "Genes having at least one occurrence of the motif CNSNNTGAACCN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the VDR [GeneSymbol=VDR] transcription factor binding site V$VDR_Q6 (v7.4 TRANSFAC).", "WCTCNATGGY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M59 WCTCNATGGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "WCAANNNYCAG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M152 WCAANNNYCAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "WHN_B": "Genes having at least one occurrence of the motif ANNGACGCTNN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the FOXN1 [GeneSymbol=FOXN1] transcription factor binding site V$WHN_B (v7.4 TRANSFAC).", "WGTTNNNNNAAA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M155 WGTTNNNNNAAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "WGGAATGY_TEF1_Q6": "Genes having at least one occurrence of the highly conserved motif M79 WGGAATGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the TEAD1 [GeneSymbol=TEAD1] transcription factor binding site V$TEF1_Q6 (v7.4 TRANSFAC).", "WWTAAGGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M127 WWTAAGGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "WTTGKCTG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M46 WTTGKCTG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "XBP1_01": "Genes having at least one occurrence of the motif NNGNTGACGTGKNNNWT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the XBP1 [GeneSymbol=XBP1] transcription factor binding site V$XBP1_01 (v7.4 TRANSFAC).", "WTGAAAT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M174 WTGAAAT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "WYAAANNRNNNGCG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M126 WYAAANNRNNNGCG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YAATNRNNNYNATT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M90 YAATNRNNNYNATT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YAATNANRNNNCAG_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M147 YAATNANRNNNCAG in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YATGNWAAT_OCT_C": "Genes having at least one occurrence of the highly conserved motif M44 YATGNWAAT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$OCT_C (v7.4 TRANSFAC).", "YGACNNYACAR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M149 YGACNNYACAR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YATTNATC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M97 YATTNATC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YGCGYRCGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M30 YGCGYRCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YGCANTGCR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M96 YGCANTGCR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YGTCCTTGR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M109 YGTCCTTGR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YCATTAA_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M58 YCATTAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YKACATTT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M145 YKACATTT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YNTTTNNNANGCARM_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M166 YNTTTNNNANGCARM in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YRCCAKNNGNCGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M156 YRCCAKNNGNCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YRTCANNRCGC_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M115 YRTCANNRCGC in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YNGTTNNNATT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M170 YNGTTNNNATT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YTAAYNGCT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M168 YTAAYNGCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YTTCCNNNGGAMR_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M150 YTTCCNNNGGAMR in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YTCCCRNNAGGY_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M114 YTCCCRNNAGGY in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YWATTWNNRGCT_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M173 YWATTWNNRGCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "YTAATTAA_LHX3_01": "Genes having at least one occurrence of the highly conserved motif M61 YTAATTAA in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the LHX3 [GeneSymbol=LHX3] transcription factor binding site V$LHX3_01 (v7.4 TRANSFAC).", "YY1_01": "Genes having at least one occurrence of the motif NNNNNCCATNTWNNNWN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the YY1 [GeneSymbol=YY1] transcription factor binding site V$YY1_01 (v7.4 TRANSFAC).", "YTATTTTNR_MEF2_02": "Genes having at least one occurrence of the highly conserved motif M33 YTATTTTNR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the MEF2A [GeneSymbol=MEF2A] transcription factor binding site V$MEF2_02 (v7.4 TRANSFAC).", "YY1_02": "Genes having at least one occurrence of the motif NNNCGGCCATCTTGNCTSNW in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the YY1 [GeneSymbol=YY1] transcription factor binding site V$YY1_02 (v7.4 TRANSFAC).", "YY1_Q6": "Genes having at least one occurrence of the motif GCCATNTTN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the YY1 [GeneSymbol=YY1] transcription factor binding site V$YY1_Q6 (v7.4 TRANSFAC).", "YYCATTCAWW_UNKNOWN": "Genes having at least one occurrence of the highly conserved motif M52 YYCATTCAWW in the regions spanning 4 kb centered on their transcription starting sites [-2kb,+2kb].  The motif does not match any known transcription factor binding site.", "ZF5_B": "Genes having at least one occurrence of the motif NRNGNGCGCGCWN in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZFP161 [GeneSymbol=ZFP161] transcription factor binding site V$ZF5_B (v7.4 TRANSFAC).", "ZF5_01": "Genes having at least one occurrence of the motif GSGCGCGR in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZFP161 [GeneSymbol=ZFP161] transcription factor binding site V$ZF5_01 (v7.4 TRANSFAC).", "ZIC2_01": "Genes having at least one occurrence of the motif KGGGTGGTC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZIC2 [GeneSymbol=ZIC2] transcription factor binding site V$ZIC2_01 (v7.4 TRANSFAC).", "ZIC1_01": "Genes having at least one occurrence of the motif KGGGTGGTC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZIC1 [GeneSymbol=ZIC1] transcription factor binding site V$ZIC1_01 (v7.4 TRANSFAC).", "ZID_01": "Genes having at least one occurrence of the motif NGGCTCYATCAYC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the transcription factor binding site V$ZID_01 (v7.4 TRANSFAC).", "ZIC3_01": "Genes having at least one occurrence of the motif NGGGKGGTC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ZIC3 [GeneSymbol=ZIC3] transcription factor binding site V$ZIC3_01 (v7.4 TRANSFAC).", "GAVISH_3CA_MALIGNANT_METAPROGRAM_10_PROTEIN_MATURATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_11_TRANSLATION_INITIATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_12_EMT_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_13_EMT_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_14_EMT_3": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_15_EMT_4": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_17_INTERFERON_MHC_II_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_16_MES_GLIOMA": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_18_INTERFERON_MHC_II_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_19_EPITHELIAL_SENESCENCE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_20_MYC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_21_RESPIRATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_22_SECRETED_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_23_SECRETED_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_24_CILIA": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_25_ASTROCYTES": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_26_NPC_GLIOMA": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_27_OLIGO_PROGENITOR": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_28_OLIGO_NORMAL": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_29_NPC_OPC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_2_CELL_CYCLE_G1_S": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_30_PDAC_CLASSICAL": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_32_SKIN_PIGMENTATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_31_ALVEOLAR": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_33_RBCS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_36_IG": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_35_HEMATO_RELATED_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_34_PLATELET_ACTIVATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_39_METAL_RESPONSE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_3_CELL_CYLCE_HMG_RICH": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_37_HEMATO_RELATED_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_38_GLUTATHIONE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_41_UNASSIGNED": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_40_PDAC_RELATED": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_5_STRESS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_8_PROTEASOMAL_DEGRADATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_7_STRESS_IN_VITRO": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_CELL_CYCLE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_METAPROGRAM_6_HYPOXIA": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_MALIGNANT_METAPROGRAM_9_UNFOLDED_PROTEIN_RESPONSE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_GERMINAL_CENTER": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_B_CELLS_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_HSP_STRESS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_INTERFERON": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_MEMORY": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_METABOLISM_MYC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_MHC_II": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_STRESS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_PLASMA": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_PROGENITOR": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_B_CELLS_RESPIRATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_CELL_CYCLE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_CYTOTOXIC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_GLYCOLYSIS_MYC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_DYSFUNCTION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_INTERFERON": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_NAIVE_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_STRESS_HSP": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_T_REG": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_NAIVE_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_UNASSIGNED": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CELL_CYCLE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CYTOTOXIC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_DYSFUNCTION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_HEAT_SHOCK": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_NAIVE_3": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_MEMORY_NAIVE_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_NAIVE_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_GLYCOLYSIS_MYC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_INTERFERON": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_UNASSIGNED_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_COAGULATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_UNASSIGNED_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_CELL_CYCLE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_3": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_4": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_6": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_5": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_7": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_HEV_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_HEV_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_INTERFERON": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_NF_KB": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_NOTCH_SIGNALING": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_STRESS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_ALVEOLAR": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_ANDROGEN_PROSTATE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_CELL_CYCLE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_COLON_RELATED": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_CILIA": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_EMT_LIKE_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_EMT_LIKE_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPI3": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPI4": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPISEN": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPI_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_INTERFERON_MHC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_METABOLISM_KIDNEY_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPI_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_METABOLISM_KIDNEY_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_NEUROENDOCRINE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_MYC": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_PDAC_RELATED_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_PDAC_RELATED_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_RESPIRATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_PDAC_RELATED_3": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_SECRETED": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_STRESS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_EPITHELIAL_V_ATPASE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_10": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_3": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_5": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_6": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_9": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_8": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_7": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_HYPOXIA": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_COMPLEMENT": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CELL_CYCLE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_LIPID_METABOLISM": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_INTERFERON": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_METAL_RESPONSE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_MHC_II": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_PERICYTE_LIKE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_MYOFIBROBLASTS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_MHC_II_CYTOKINE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_PI16_POS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_CELL_CYCLE": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_FIBROBLASTS_STRESS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_LIPID_ASSOCIATED": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_INTERFERON": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_MAC_2": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_MAC_1": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_MAC_3": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_MONOCYTE_SECRETED": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_MES_GLYCOLYSIS": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_RESPIRATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_MYC_MITOCHONDRIA": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_PROTEASOMAL_DEGRADATION": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_STRESS_HSP": "Genes upregulated in subsets of cells of a given type within various tumors", "GAVISH_3CA_METAPROGRAM_MACROPHAGES_UNFOLDED_PROTEIN_RESPONSE": "Genes upregulated in subsets of cells of a given type within various tumors", "CAR_IGFBP1": "Neighborhood of IGFBP1", "CAR_HPX": "Neighborhood of HPX", "CAR_MYST2": "Neighborhood of MYST2", "CAR_MLANA": "Neighborhood of MLANA", "CAR_WBSCR22": "Neighborhood of WBSCR22", "CAR_TNFRSF25": "Neighborhood of TNFRSF25", "GCM_AIP": "Neighborhood of AIP", "GCM_ACTG1": "Neighborhood of ACTG1", "GCM_ANP32B": "Neighborhood of ANP32B", "GCM_APEX1": "Neighborhood of APEX1", "GCM_ATM": "Neighborhood of ATM", "GCM_AQP4": "Neighborhood of AQP4", "GCM_BAG5": "Neighborhood of BAG5", "GCM_BCL2L1": "Neighborhood of BCL2L1", "GCM_BECN1": "Neighborhood of BECN1", "GCM_BMPR2": "Neighborhood of BMPR2", "GCM_CASP2": "Neighborhood of CASP2", "GCM_BNIP1": "Neighborhood of BNIP1", "GCM_CALM1": "Neighborhood of CALM1", "GCM_CBFB": "Neighborhood of CBFB", "GCM_CDH5": "Neighborhood of CDH5", "GCM_CHUK": "Neighborhood of CHUK", "GCM_CRKL": "Neighborhood of CRKL", "GCM_CSNK1A1": "Neighborhood of CSNK1A1", "GCM_CSNK1D": "Neighborhood of CSNK1D", "GCM_DEAF1": "Neighborhood of DEAF1", "GCM_CSNK2B": "Neighborhood of CSNK2B", "GCM_DDX11": "Neighborhood of DDX11", "GCM_DDX5": "Neighborhood of DDX5", "GCM_DENR": "Neighborhood of DENR", "GCM_DPF2": "Neighborhood of DPF2", "GCM_DFFA": "Neighborhood of DFFA", "GCM_DLG1": "Neighborhood of DLG1", "GCM_ERBB2IP": "Neighborhood of ERBB2IP", "GCM_ERCC4": "Neighborhood of ERCC4", "GCM_FANCL": "Neighborhood of FANCL", "GCM_FCGR2B": "Neighborhood of FCGR2B", "GCM_FANCC": "Neighborhood of FANCC", "GCM_GSPT1": "Neighborhood of GSPT1", "GCM_HDAC1": "Neighborhood of HDAC1", "GCM_HMGA2": "Neighborhood of HMGA2", "GCM_GSTA4": "Neighborhood of GSTA4", "GCM_HBP1": "Neighborhood of HBP1", "GCM_IL6ST": "Neighborhood of IL6ST", "GCM_ING1": "Neighborhood of ING1", "GCM_LTK": "Neighborhood of LTK", "GCM_MAP1B": "Neighborhood of MAP1B", "GCM_MAP4K4": "Neighborhood of MAP4K4", "GCM_MAX": "Neighborhood of MAX", "GCM_MAPK10": "Neighborhood of MAPK10", "GCM_MSN": "Neighborhood of MSN", "GCM_MLL": "Neighborhood of MLL", "GCM_MYCL1": "Neighborhood of MYCL1", "GCM_NUMA1": "Neighborhood of NUMA1", "GCM_NPM1": "Neighborhood of NPM1", "GCM_NCAM1": "Neighborhood of NCAM1", "GCM_PPM1D": "Neighborhood of PPM1D", "GCM_NF2": "Neighborhood of NF2", "GCM_MYST2": "Neighborhood of MYST2", "GCM_PFN1": "Neighborhood of PFN1", "GCM_PPP1CC": "Neighborhood of PPP1CC", "GCM_PRKAG1": "Neighborhood of PRKAG1", "GCM_PRKCG": "Neighborhood of PRKCG", "GCM_PSME1": "Neighborhood of PSME1", "GCM_PTK2": "Neighborhood of PTK2", "GCM_PTPRD": "Neighborhood of PTPRD", "GCM_RAD21": "Neighborhood of RAD21", "GCM_PTPRU": "Neighborhood of PTPRU", "GCM_RAF1": "Neighborhood of RAF1", "GCM_RAP2A": "Neighborhood of RAP2A", "GCM_RAB10": "Neighborhood of RAB10", "GCM_RBM8A": "Neighborhood of RBM8A", "GCM_RAN": "Neighborhood of RAN", "GCM_RING1": "Neighborhood of RING1", "GCM_SIRT2": "Neighborhood of SIRT2", "GCM_SMARCC1": "Neighborhood of SMARCC1", "GCM_SMARCD1": "Neighborhood of SMARCD1", "GCM_SMO": "Neighborhood of SMO", "GCM_TEC": "Neighborhood of TEC", "GCM_SUPT4H1": "Neighborhood of SUPT4H1", "GCM_SUFU": "Neighborhood of SUFU", "GCM_TPR": "Neighborhood of TPR", "GCM_TINF2": "Neighborhood of TINF2", "GCM_TPT1": "Neighborhood of TPT1", "GCM_USP6": "Neighborhood of USP6", "GCM_VAV1": "Neighborhood of VAV1", "GNF2_AF1Q": "Neighborhood of AF1Q", "GCM_UBE2N": "Neighborhood of UBE2N", "GCM_ZNF198": "Neighborhood of ZNF198", "GNF2_ANP32B": "Neighborhood of ANP32B", "GNF2_ATM": "Neighborhood of ATM", "GNF2_ANK1": "Neighborhood of ANK1", "GNF2_APEX1": "Neighborhood of APEX1", "GNF2_BNIP2": "Neighborhood of BNIP2", "GNF2_BUB1": "Neighborhood of BUB1", "GNF2_BUB3": "Neighborhood of BUB3", "GNF2_BNIP3L": "Neighborhood of BNIP3L", "GNF2_BUB1B": "Neighborhood of BUB1B", "GNF2_CASP1": "Neighborhood of CASP1", "GNF2_CASP4": "Neighborhood of CASP4", "GNF2_CASP8": "Neighborhood of CASP8", "GNF2_CARD15": "Neighborhood of CARD15", "GNF2_CBFB": "Neighborhood of CBFB", "GNF2_CCNA1": "Neighborhood of CCNA1", "GNF2_CD14": "Neighborhood of CD14", "GNF2_CCNA2": "Neighborhood of CCNA2", "GNF2_CCNB2": "Neighborhood of CCNB2", "GNF2_CD1D": "Neighborhood of CD1D", "GNF2_CD48": "Neighborhood of CD48", "GNF2_CD7": "Neighborhood of CD7", "GNF2_CD33": "Neighborhood of CD33", "GNF2_CD97": "Neighborhood of CD97", "GNF2_CD53": "Neighborhood of CD53", "GNF2_CDC2": "Neighborhood of CDC2", "GNF2_CDH11": "Neighborhood of CDH11", "GNF2_CDC20": "Neighborhood of CDC20", "GNF2_CDH3": "Neighborhood of CDH3", "GNF2_CDC27": "Neighborhood of CDC27", "GNF2_CDKN1C": "Neighborhood of CDKN1C", "GNF2_CEBPA": "Neighborhood of CEBPA", "GNF2_CENPF": "Neighborhood of CENPF", "GNF2_CENPE": "Neighborhood of CENPE", "GNF2_CKS1B": "Neighborhood of CKS1B", "GNF2_CKS2": "Neighborhood of CKS2", "GNF2_CYP2B6": "Neighborhood of CYP2B6", "GNF2_DAP3": "Neighborhood of DAP3", "GNF2_DEK": "Neighborhood of DEK", "GNF2_DDX5": "Neighborhood of DDX5", "GNF2_DENR": "Neighborhood of DENR", "GNF2_EGFR": "Neighborhood of EGFR", "GNF2_DNM1": "Neighborhood of DNM1", "GNF2_ESPL1": "Neighborhood of ESPL1", "GNF2_EIF3S6": "Neighborhood of EIF3S6", "GNF2_ELAC2": "Neighborhood of ELAC2", "GNF2_FBL": "Neighborhood of FBL", "GNF2_FGR": "Neighborhood of FGR", "GNF2_FEN1": "Neighborhood of FEN1", "GNF2_FOS": "Neighborhood of FOS", "GNF2_G22P1": "Neighborhood of G22P1", "GNF2_GLTSCR2": "Neighborhood of GLTSCR2", "GNF2_H2AFX": "Neighborhood of H2AFX", "GNF2_GSTM1": "Neighborhood of GSTM1", "GNF2_HAT1": "Neighborhood of HAT1", "GNF2_HCK": "Neighborhood of HCK", "GNF2_HDAC1": "Neighborhood of HDAC1", "GNF2_HLA_C": "Neighborhood of HLA-C", "GNF2_HMMR": "Neighborhood of HMMR", "GNF2_HPN": "Neighborhood of HPN", "GNF2_ICAM3": "Neighborhood of ICAM3", "GNF2_IGF1": "Neighborhood of IGF1", "GNF2_HPX": "Neighborhood of HPX", "GNF2_IGFBP1": "Neighborhood of IGFBP1", "GNF2_IL2RB": "Neighborhood of IL2RB", "GNF2_INPP5D": "Neighborhood of INPP5D", "GNF2_JAK1": "Neighborhood of JAK1", "GNF2_ITGAL": "Neighborhood of ITGAL", "GNF2_ITGB2": "Neighborhood of ITGB2", "GNF2_LYN": "Neighborhood of LYN", "GNF2_KISS1": "Neighborhood of KISS1", "GNF2_KPNB1": "Neighborhood of KPNB1", "GNF2_LCAT": "Neighborhood of LCAT", "GNF2_MAP2K3": "Neighborhood of MAP2K3", "GNF2_MATK": "Neighborhood of MATK", "GNF2_MAPT": "Neighborhood of MAPT", "GNF2_MBD4": "Neighborhood of MBD4", "GNF2_MCL1": "Neighborhood of MCL1", "GNF2_MCM4": "Neighborhood of MCM4", "GNF2_MKI67": "Neighborhood of MKI67", "GNF2_MCM5": "Neighborhood of MCM5", "GNF2_MMP1": "Neighborhood of MMP1", "GNF2_MLF1": "Neighborhood of MLF1", "GNF2_MLH1": "Neighborhood of MLH1", "GNF2_MSH2": "Neighborhood of MSH2", "GNF2_MMP11": "Neighborhood of MMP11", "GNF2_MSH6": "Neighborhood of MSH6", "GNF2_MSN": "Neighborhood of MSN", "GNF2_MYL3": "Neighborhood of MYL3", "GNF2_MYD88": "Neighborhood of MYD88", "GNF2_MYL2": "Neighborhood of MYL2", "GNF2_NPM1": "Neighborhood of NPM1", "GNF2_PAK2": "Neighborhood of PAK2", "GNF2_NS": "Neighborhood of NS", "GNF2_PA2G4": "Neighborhood of PA2G4", "GNF2_PCAF": "Neighborhood of PCAF", "GNF2_PCNA": "Neighborhood of PCNA", "GNF2_PECAM1": "Neighborhood of PECAM1", "GNF2_PRDX2": "Neighborhood of PRDX2", "GNF2_PPP6C": "Neighborhood of PPP6C", "GNF2_PTPN4": "Neighborhood of PTPN4", "GNF2_PTX3": "Neighborhood of PTX3", "GNF2_PTPN6": "Neighborhood of PTPN6", "GNF2_PTPRC": "Neighborhood of PTPRC", "GNF2_RAB7L1": "Neighborhood of RAB7L1", "GNF2_RAB3A": "Neighborhood of RAB3A", "GNF2_RAD23A": "Neighborhood of RAD23A", "GNF2_RAN": "Neighborhood of RAN", "GNF2_RAP1B": "Neighborhood of RAP1B", "GNF2_RBBP6": "Neighborhood of RBBP6", "GNF2_RPA1": "Neighborhood of RPA1", "GNF2_RFC4": "Neighborhood of RFC4", "GNF2_RFC3": "Neighborhood of RFC3", "GNF2_RRM1": "Neighborhood of RRM1", "GNF2_RRM2": "Neighborhood of RRM2", "GNF2_RTN1": "Neighborhood of RTN1", "GNF2_SELL": "Neighborhood of SELL", "GNF2_S100A4": "Neighborhood of S100A4", "GNF2_SERPINB5": "Neighborhood of SERPINB5", "GNF2_SERPINI2": "Neighborhood of SERPINI2", "GNF2_SMC2L1": "Neighborhood of SMC2L1", "GNF2_SMC1L1": "Neighborhood of SMC1L1", "GNF2_SNRK": "Neighborhood of SNRK", "GNF2_SPINK1": "Neighborhood of SPINK1", "GNF2_SMC4L1": "Neighborhood of SMC4L1", "GNF2_SPI1": "Neighborhood of SPI1", "GNF2_SPRR1B": "Neighborhood of SPRR1B", "GNF2_SPTA1": "Neighborhood of SPTA1", "GNF2_ST13": "Neighborhood of ST13", "GNF2_SPTB": "Neighborhood of SPTB", "GNF2_TAL1": "Neighborhood of TAL1", "GNF2_TDG": "Neighborhood of TDG", "GNF2_STAT6": "Neighborhood of STAT6", "GNF2_TM4SF2": "Neighborhood of TM4SF2", "GNF2_TIMP2": "Neighborhood of TIMP2", "GNF2_TNFRSF1B": "Neighborhood of TNFRSF1B", "GNF2_TNFSF10": "Neighborhood of TNFSF10", "GNF2_TPT1": "Neighborhood of TPT1", "GNF2_TST": "Neighborhood of TST", "GNF2_TTK": "Neighborhood of TTK", "GNF2_TYK2": "Neighborhood of TYK2", "GNF2_TTN": "Neighborhood of TTN", "GNF2_VAV1": "Neighborhood of VAV1", "GNF2_UBE2I": "Neighborhood of UBE2I", "GNF2_ZAP70": "Neighborhood of ZAP70", "GNF2_XRCC5": "Neighborhood of XRCC5", "MORF_ACP1": "Neighborhood of ACP1", "MORF_AATF": "Neighborhood of AATF", "MORF_AP3D1": "Neighborhood of AP3D1", "MORF_ACTG1": "Neighborhood of ACTG1", "MORF_ARAF1": "Neighborhood of ARAF1", "MORF_AP2M1": "Neighborhood of AP2M1", "MORF_ANP32B": "Neighborhood of ANP32B", "MORF_ATOX1": "Neighborhood of ATOX1", "MORF_BAG5": "Neighborhood of BAG5", "MORF_ARL3": "Neighborhood of ARL3", "MORF_ATRX": "Neighborhood of ATRX", "MORF_ATF2": "Neighborhood of ATF2", "MORF_BMI1": "Neighborhood of BMI1", "MORF_BCL2": "Neighborhood of BCL2", "MORF_BCL2L11": "Neighborhood of BCL2L11", "MORF_BMPR2": "Neighborhood of BMPR2", "MORF_BECN1": "Neighborhood of BECN1", "MORF_BNIP1": "Neighborhood of BNIP1", "MORF_BRCA1": "Neighborhood of BRCA1", "MORF_BUB1": "Neighborhood of BUB1", "MORF_BUB1B": "Neighborhood of BUB1B", "MORF_BUB3": "Neighborhood of BUB3", "MORF_CASP10": "Neighborhood of CASP10", "MORF_CCNF": "Neighborhood of CCNF", "MORF_CAMK4": "Neighborhood of CAMK4", "MORF_CASP2": "Neighborhood of CASP2", "MORF_CCNI": "Neighborhood of CCNI", "MORF_CD8A": "Neighborhood of CD8A", "MORF_CDC10": "Neighborhood of CDC10", "MORF_CDC16": "Neighborhood of CDC16", "MORF_CDC2L5": "Neighborhood of CDC2L5", "MORF_CDH4": "Neighborhood of CDH4", "MORF_CSNK2B": "Neighborhood of CSNK2B", "MORF_CDK2": "Neighborhood of CDK2", "MORF_CSNK1D": "Neighborhood of CSNK1D", "MORF_CNTN1": "Neighborhood of CNTN1", "MORF_CUL1": "Neighborhood of CUL1", "MORF_CTSB": "Neighborhood of CTSB", "MORF_CTBP1": "Neighborhood of CTBP1", "MORF_DCC": "Neighborhood of DCC", "MORF_DAP": "Neighborhood of DAP", "MORF_DAP3": "Neighborhood of DAP3", "MORF_DEAF1": "Neighborhood of DEAF1", "MORF_DDX11": "Neighborhood of DDX11", "MORF_DDB1": "Neighborhood of DDB1", "MORF_DNMT1": "Neighborhood of DNMT1", "MORF_DMPK": "Neighborhood of DMPK", "MORF_DEK": "Neighborhood of DEK", "MORF_EI24": "Neighborhood of EI24", "MORF_EIF3S6": "Neighborhood of EIF3S6", "MORF_EIF3S2": "Neighborhood of EIF3S2", "MORF_EIF4A2": "Neighborhood of EIF4A2", "MORF_EPHA7": "Neighborhood of EPHA7", "MORF_ERCC2": "Neighborhood of ERCC2", "MORF_EIF4E": "Neighborhood of EIF4E", "MORF_ESPL1": "Neighborhood of ESPL1", "MORF_ETV3": "Neighborhood of ETV3", "MORF_ERH": "Neighborhood of ERH", "MORF_FBL": "Neighborhood of FBL", "MORF_ERCC4": "Neighborhood of ERCC4", "MORF_ESR1": "Neighborhood of ESR1", "MORF_FANCG": "Neighborhood of FANCG", "MORF_FEN1": "Neighborhood of FEN1", "MORF_FLT1": "Neighborhood of FLT1", "MORF_FDXR": "Neighborhood of FDXR", "MORF_FOSL1": "Neighborhood of FOSL1", "MORF_FRK": "Neighborhood of FRK", "MORF_GMPS": "Neighborhood of GMPS", "MORF_FSHR": "Neighborhood of FSHR", "MORF_G22P1": "Neighborhood of G22P1", "MORF_GPX4": "Neighborhood of GPX4", "MORF_GNB1": "Neighborhood of GNB1", "MORF_GSPT1": "Neighborhood of GSPT1", "MORF_HAT1": "Neighborhood of HAT1", "MORF_HDAC1": "Neighborhood of HDAC1", "MORF_HEAB": "Neighborhood of HEAB", "MORF_HDAC2": "Neighborhood of HDAC2", "MORF_IKBKG": "Neighborhood of IKBKG", "MORF_IFNA1": "Neighborhood of IFNA1", "MORF_IL13": "Neighborhood of IL13", "MORF_IL4": "Neighborhood of IL4", "MORF_IL16": "Neighborhood of IL16", "MORF_IL9": "Neighborhood of IL9", "MORF_ITGA2": "Neighborhood of ITGA2", "MORF_JAG1": "Neighborhood of JAG1", "MORF_JAK3": "Neighborhood of JAK3", "MORF_JUND": "Neighborhood of JUND", "MORF_KDR": "Neighborhood of KDR", "MORF_LCAT": "Neighborhood of LCAT", "MORF_LMO1": "Neighborhood of LMO1", "MORF_MAP2K2": "Neighborhood of MAP2K2", "MORF_LTK": "Neighborhood of LTK", "MORF_MAGEA8": "Neighborhood of MAGEA8", "MORF_MAP3K14": "Neighborhood of MAP3K14", "MORF_MAGEA9": "Neighborhood of MAGEA9", "MORF_MDM2": "Neighborhood of MDM2", "MORF_MBD4": "Neighborhood of MBD4", "MORF_MSH2": "Neighborhood of MSH2", "MORF_MAP2K7": "Neighborhood of MAP2K7", "MORF_MLLT10": "Neighborhood of MLLT10", "MORF_MTA1": "Neighborhood of MTA1", "MORF_MYC": "Neighborhood of MYC", "MORF_MT4": "Neighborhood of MT4", "MORF_MSH3": "Neighborhood of MSH3", "MORF_MYST2": "Neighborhood of MYST2", "MORF_MYL3": "Neighborhood of MYL3", "MORF_NME2": "Neighborhood of NME2", "MORF_NF1": "Neighborhood of NF1", "MORF_ORC1L": "Neighborhood of ORC1L", "MORF_NOS2A": "Neighborhood of NOS2A", "MORF_NPM1": "Neighborhood of NPM1", "MORF_PAPSS1": "Neighborhood of PAPSS1", "MORF_PCNA": "Neighborhood of PCNA", "MORF_PAX7": "Neighborhood of PAX7", "MORF_PDPK1": "Neighborhood of PDPK1", "MORF_PDCD1": "Neighborhood of PDCD1", "MORF_PML": "Neighborhood of PML", "MORF_PHB": "Neighborhood of PHB", "MORF_PPP2CA": "Neighborhood of PPP2CA", "MORF_PPP2R4": "Neighborhood of PPP2R4", "MORF_PPP1CA": "Neighborhood of PPP1CA", "MORF_PPP1CC": "Neighborhood of PPP1CC", "MORF_PPP2R5E": "Neighborhood of PPP2R5E", "MORF_PPP5C": "Neighborhood of PPP5C", "MORF_PPP2R5B": "Neighborhood of PPP2R5B", "MORF_PPP6C": "Neighborhood of PPP6C", "MORF_PRDX3": "Neighborhood of PRDX3", "MORF_PRKACA": "Neighborhood of PRKACA", "MORF_PRKAR1A": "Neighborhood of PRKAR1A", "MORF_PRKAG1": "Neighborhood of PRKAG1", "MORF_PRKDC": "Neighborhood of PRKDC", "MORF_PRKCA": "Neighborhood of PRKCA", "MORF_PSMC2": "Neighborhood of PSMC2", "MORF_PTEN": "Neighborhood of PTEN", "MORF_PSMC1": "Neighborhood of PSMC1", "MORF_PSMF1": "Neighborhood of PSMF1", "MORF_PTPN9": "Neighborhood of PTPN9", "MORF_PTPN11": "Neighborhood of PTPN11", "MORF_PTPRB": "Neighborhood of PTPRB", "MORF_PTPRR": "Neighborhood of PTPRR", "MORF_RAB11A": "Neighborhood of RAB11A", "MORF_RAB5A": "Neighborhood of RAB5A", "MORF_RAB3A": "Neighborhood of RAB3A", "MORF_RAB1A": "Neighborhood of RAB1A", "MORF_RAB6A": "Neighborhood of RAB6A", "MORF_RAC1": "Neighborhood of RAC1", "MORF_RAD21": "Neighborhood of RAD21", "MORF_RAD23A": "Neighborhood of RAD23A", "MORF_RAF1": "Neighborhood of RAF1", "MORF_RAD54L": "Neighborhood of RAD54L", "MORF_RAD51L3": "Neighborhood of RAD51L3", "MORF_RAD23B": "Neighborhood of RAD23B", "MORF_RAGE": "Neighborhood of RAGE", "MORF_RAN": "Neighborhood of RAN", "MORF_RBBP8": "Neighborhood of RBBP8", "MORF_RBM8A": "Neighborhood of RBM8A", "MORF_RAP1A": "Neighborhood of RAP1A", "MORF_REV3L": "Neighborhood of REV3L", "MORF_RFC4": "Neighborhood of RFC4", "MORF_RFC1": "Neighborhood of RFC1", "MORF_RFC5": "Neighborhood of RFC5", "MORF_RPA1": "Neighborhood of RPA1", "MORF_RPA2": "Neighborhood of RPA2", "MORF_RUNX1": "Neighborhood of RUNX1", "MORF_RRM1": "Neighborhood of RRM1", "MORF_SMC1L1": "Neighborhood of SMC1L1", "MORF_SART1": "Neighborhood of SART1", "MORF_SKP1A": "Neighborhood of SKP1A", "MORF_SNRP70": "Neighborhood of SNRP70", "MORF_SP3": "Neighborhood of SP3", "MORF_SOD1": "Neighborhood of SOD1", "MORF_SS18": "Neighborhood of SS18", "MORF_STK17A": "Neighborhood of STK17A", "MORF_TERF1": "Neighborhood of TERF1", "MORF_TERF2IP": "Neighborhood of TERF2IP", "MORF_THPO": "Neighborhood of THPO", "MORF_TFDP2": "Neighborhood of TFDP2", "MORF_SUPT3H": "Neighborhood of SUPT3H", "MORF_THRA": "Neighborhood of THRA", "MORF_TPR": "Neighborhood of TPR", "MORF_TNFRSF6": "Neighborhood of TNFRSF6", "MORF_TNFRSF25": "Neighborhood of TNFRSF25", "MORF_TPT1": "Neighborhood of TPT1", "MORF_TTN": "Neighborhood of TTN", "MORF_UBE2A": "Neighborhood of UBE2A", "MORF_UNG": "Neighborhood of UNG", "MORF_UBE2N": "Neighborhood of UBE2N", "MORF_USP5": "Neighborhood of USP5", "MORF_UBE2I": "Neighborhood of UBE2I", "MORF_WNT1": "Neighborhood of WNT1", "MORF_XPC": "Neighborhood of XPC", "MORF_ZNF10": "Neighborhood of ZNF10", "MORF_XRCC5": "Neighborhood of XRCC5", "MODULE_101": "Genes in the cancer module 101.", "MODULE_102": "Nucleotide (purine) biosynthesis.", "MODULE_103": "Genes in the cancer module 103.", "MODULE_1": "Ovary genes.", "MODULE_106": "Cytochrome P450.", "MODULE_105": "Genes in the cancer module 105.", "MODULE_104": "Genes in the cancer module 104.", "MODULE_100": "Genes in the cancer module 100.", "MODULE_107": "Genes in the cancer module 107.", "MODULE_108": "Genes in the cancer module 108.", "MODULE_110": "Genes in the cancer module 110.", "MODULE_109": "Serine proteases.", "MODULE_111": "Genes in the cancer module 111.", "MODULE_115": "Genes in the cancer module 115.", "MODULE_112": "Genes in the cancer module 112.", "MODULE_11": "Genes in the cancer module 11.", "MODULE_116": "Genes in the cancer module 116.", "MODULE_113": "Genes in the cancer module 113.", "MODULE_119": "Genes in the cancer module 119.", "MODULE_114": "Protein biosynthesis and ribosomes.", "MODULE_118": "cell line expressed genes.", "MODULE_120": "Genes in the cancer module 120.", "MODULE_121": "Genes in the cancer module 121.", "MODULE_117": "Signaling.", "MODULE_123": "Genes in the cancer module 123.", "MODULE_12": "Spinal cord (neuro-development) genes.", "MODULE_122": "Adhesion molecules.", "MODULE_124": "Transcription.", "MODULE_125": "Genes in the cancer module 125.", "MODULE_127": "Genes in the cancer module 127.", "MODULE_126": "Lymphoma and immune response expression clusters.", "MODULE_128": "Genes in the cancer module 128.", "MODULE_129": "Signaling.", "MODULE_130": "Complement.", "MODULE_132": "Genes in the cancer module 132.", "MODULE_134": "Genes in the cancer module 134.", "MODULE_131": "Blood coagulation factors.", "MODULE_133": "Genes in the cancer module 133.", "MODULE_135": "Genes in the cancer module 135.", "MODULE_13": "Genes in the cancer module 12.", "MODULE_139": "Genes in the cancer module 139.", "MODULE_136": "Genes in the cancer module 136.", "MODULE_14": "Genes in the cancer module 13.", "MODULE_137": "CNS genes.", "MODULE_138": "Genes in the cancer module 138.", "MODULE_143": "Genes in the cancer module 143.", "MODULE_141": "Genes in the cancer module 141.", "MODULE_145": "Genes in the cancer module 145.", "MODULE_146": "Genes in the cancer module 146.", "MODULE_148": "Genes in the cancer module 148.", "MODULE_149": "Translation factors.", "MODULE_147": "GPCR.", "MODULE_150": "Ttranslation elongation.", "MODULE_153": "Genes in the cancer module 153.", "MODULE_152": "Oxidative phosphorylation and ATP synthesis.", "MODULE_155": "Genes in the cancer module 155.", "MODULE_15": "Genes in the cancer module 14.", "MODULE_154": "Intermediate filaments.", "MODULE_151": "Genes in the cancer module 151.", "MODULE_156": "Genes in the cancer module 156.", "MODULE_158": "DNA replication.", "MODULE_157": "Genes in the cancer module 157.", "MODULE_159": "Translation regulation.", "MODULE_160": "tRNA synthesis.", "MODULE_162": "Genes in the cancer module 162.", "MODULE_164": "Enzyme inhibitors (esp serine proteases).", "MODULE_165": "Genes in the cancer module 165.", "MODULE_16": "Genes in the cancer module 15.", "MODULE_168": "Genes in the cancer module 168.", "MODULE_166": "Genes in the cancer module 166.", "MODULE_163": "Genes in the cancer module 163.", "MODULE_169": "Immune response.", "MODULE_170": "Immune response.", "MODULE_17": "Genes in the cancer module 17.", "MODULE_171": "Genes in the cancer module 171.", "MODULE_173": "Genes in the cancer module 173.", "MODULE_172": "Genes in the cancer module 172.", "MODULE_175": "Genes in the cancer module 175.", "MODULE_174": "Genes in the cancer module 174.", "MODULE_178": "Genes in the cancer module 178.", "MODULE_177": "Genes in the cancer module 177.", "MODULE_176": "Signaling.", "MODULE_180": "Genes in the cancer module 180.", "MODULE_18": "Genes in the cancer module 18.", "MODULE_182": "Genes in the cancer module 182.", "MODULE_184": "Genes in the cancer module 184.", "MODULE_181": "Genes in the cancer module 181.", "MODULE_183": "RNA splicing.", "MODULE_179": "Blood cells and cancer expression cancer.", "MODULE_186": "Genes in the cancer module 186.", "MODULE_189": "Genes in the cancer module 189.", "MODULE_188": "Genes in the cancer module 188.", "MODULE_191": "Genes in the cancer module 191.", "MODULE_190": "IGFBPs.", "MODULE_19": "Adrenal gland - metabolic genes.", "MODULE_194": "Genes in the cancer module 194.", "MODULE_196": "Genes in the cancer module 196.", "MODULE_192": "Genes in the cancer module 192.", "MODULE_195": "Breast cancer expression clusters.", "MODULE_198": "Genes in the cancer module 198.", "MODULE_199": "Genes in the cancer module 199.", "MODULE_197": "Genes in the cancer module 197.", "MODULE_200": "Genes in the cancer module 200.", "MODULE_20": "Genes in the cancer module 20.", "MODULE_202": "Genes in the cancer module 202.", "MODULE_2": "DRG (dorsal root ganglia) genes.", "MODULE_203": "Genes in the cancer module 203.", "MODULE_201": "Genes in the cancer module 201.", "MODULE_204": "Genes in the cancer module 204.", "MODULE_21": "Genes in the cancer module 21.", "MODULE_206": "Genes in the cancer module 206.", "MODULE_205": "Genes in the cancer module 205.", "MODULE_211": "Genes in the cancer module 211.", "MODULE_207": "Genes in the cancer module 207.", "MODULE_210": "Genes in the cancer module 210.", "MODULE_208": "Genes in the cancer module 208.", "MODULE_209": "Catabolic peptidases.", "MODULE_213": "NCI cell lines expression clusters.", "MODULE_212": "Catalytic activities / metabolism.", "MODULE_214": "Ion channels.", "MODULE_215": "Neurotransmitter (GABA) receptor.", "MODULE_218": "Genes in the cancer module 218.", "MODULE_219": "Genes in the cancer module 219.", "MODULE_22": "Genes in the cancer module 22.", "MODULE_221": "Fatty acid metabolism.", "MODULE_222": "Genes in the cancer module 222.", "MODULE_226": "Genes in the cancer module 226.", "MODULE_223": "Immune (defense) response.", "MODULE_220": "Developmental processes.", "MODULE_229": "Genes in the cancer module 229.", "MODULE_227": "Genes in the cancer module 227.", "MODULE_233": "Genes in the cancer module 233.", "MODULE_236": "Genes in the cancer module 236.", "MODULE_234": "Bone remodeling.", "MODULE_235": "AA and sulfur metabolism.", "MODULE_237": "Genes in the cancer module 237.", "MODULE_240": "Genes in the cancer module 240.", "MODULE_239": "Genes in the cancer module 239.", "MODULE_23": "Liver genes - metabolism and xenobiotics.", "MODULE_238": "Genes in the cancer module 238.", "MODULE_241": "Genes in the cancer module 241.", "MODULE_242": "Genes in the cancer module 242.", "MODULE_243": "Genes in the cancer module 243.", "MODULE_24": "Fetal liver genes - metabolism and xenobiotics.", "MODULE_245": "Genes in the cancer module 245.", "MODULE_244": "Response to DNA damage.", "MODULE_249": "Genes in the cancer module 249.", "MODULE_247": "Xenobiotic metabolism.", "MODULE_25": "Genes in the cancer module 25.", "MODULE_248": "Genes in the cancer module 248.", "MODULE_253": "Intracellular transport (MT cytoskeleton and motors).", "MODULE_254": "Genes in the cancer module 254.", "MODULE_252": "TFs and nuclear.", "MODULE_256": "Genes in the cancer module 256.", "MODULE_259": "RTK signaling.", "MODULE_262": "Cell ion homeostasis / chemokines.", "MODULE_261": "Genes in the cancer module 262.", "MODULE_255": "Genes in the cancer module 255.", "MODULE_257": "Genes in the cancer module 257.", "MODULE_26": "Genes in the cancer module 26.", "MODULE_263": "Chemotaxis (chemokines).", "MODULE_265": "Caner module 265: IL receptors.", "MODULE_264": "Genes in the cancer module 264.", "MODULE_267": "Genes in the cancer module 267.", "MODULE_272": "Genes in the cancer module 272.", "MODULE_273": "Phosphate metabolism.", "MODULE_275": "Genes in the cancer module 275.", "MODULE_274": "Vesicular transport / synapse genes.", "MODULE_278": "Ubiquitin ligases.", "MODULE_277": "Genes in the cancer module 277.", "MODULE_27": "Genes in the cancer module 27.", "MODULE_28": "Genes in the cancer module 28.", "MODULE_279": "Genes in the cancer module 279.", "MODULE_281": "Phosphatase regulators.", "MODULE_280": "Metal ion (zinc) binding.", "MODULE_284": "Genes in the cancer module 284.", "MODULE_285": "Genes in the cancer module 285.", "MODULE_286": "Genes in the cancer module 286", "MODULE_29": "Genes in the cancer module 29.", "MODULE_287": "Genes in the cancer module 287.", "MODULE_289": "Genes in the cancer module 289.", "MODULE_288": "Genes in the cancer module 288.", "MODULE_293": "Genes in the cancer module 293.", "MODULE_291": "B-cell malignancies expression clusters.", "MODULE_292": "Genes in the cancer module 292.", "MODULE_294": "Genes in the cancer module 294.", "MODULE_298": "Keratin.", "MODULE_295": "Genes in the cancer module 295.", "MODULE_297": "Genes in the cancer module 297.", "MODULE_300": "Programmed cell death.", "MODULE_299": "Genes in the cancer module 299.", "MODULE_305": "CoA and fatty acid metabolism.", "MODULE_303": "Genes in the cancer module 303.", "MODULE_301": "Genes in the cancer module 301.", "MODULE_306": "Glycolysis and TCA cycle.", "MODULE_3": "Genes in the cancer module 3.", "MODULE_307": "Oxidative phosphorylation (COX and ATPases).", "MODULE_310": "ROS metabolism.", "MODULE_308": "Pol II transcription.", "MODULE_311": "Genes in the cancer module 311.", "MODULE_313": "Genes in the cancer module 313.", "MODULE_315": "Spindle and kinetochore.", "MODULE_312": "Viral anti-apoptotic evasion mechanisms.", "MODULE_316": "Ion channels.", "MODULE_318": "Genes in the cancer module 318.", "MODULE_320": "Cancer module 320: M phase.", "MODULE_317": "Genes in the cancer module 317.", "MODULE_32": "Genes in the cancer module 32.", "MODULE_321": "Genes in the cancer module 321.", "MODULE_322": "Genes in the cancer module 322.", "MODULE_323": "Genes in the cancer module 323.", "MODULE_325": "Genes in the cancer module 325.", "MODULE_324": "Metal / Ca ion binding.", "MODULE_326": "Genes in the cancer module 326.", "MODULE_327": "Genes in the cancer module 327.", "MODULE_328": "AcetylCholine receptors.", "MODULE_330": "Genes in the cancer module 330.", "MODULE_329": "Genes in the cancer module 329.", "MODULE_333": "Genes in the cancer module 333.", "MODULE_332": "Genes in the cancer module 332.", "MODULE_331": "Genes in the cancer module 331.", "MODULE_335": "Genes in the cancer module 335.", "MODULE_33": "Immune / stress response genes.", "MODULE_334": "Genes in the cancer module 334.", "MODULE_337": "Nucleotide metabolism.", "MODULE_340": "Genes in the cancer module 340.", "MODULE_341": "Genes in the cancer module 341.", "MODULE_342": "Genes in the cancer module 342.", "MODULE_343": "Nitrogen metabolism.", "MODULE_346": "Genes in the cancer module 346.", "MODULE_345": "Immune response and Ag processing and presentation.", "MODULE_349": "Genes in the cancer module 349.", "MODULE_35": "Genes in the cancer module 35.", "MODULE_352": "Nuclear pore complex.", "MODULE_355": "Protein folding.", "MODULE_354": "AA biosynthesis.", "MODULE_350": "Genes in the cancer module 350.", "MODULE_356": "Genes in the cancer module 356.", "MODULE_357": "Intermediate filaments and keratins.", "MODULE_36": "Genes in the cancer module 36.", "MODULE_358": "B lymphoma expression clusters.", "MODULE_360": "Genes in the cancer module 360.", "MODULE_366": "Breast cancer expression clusters.", "MODULE_362": "Angiogenesis.", "MODULE_367": "Genes in the cancer module 367.", "MODULE_361": "B lymphoma expression clusters.", "MODULE_363": "Genes in the cancer module 363.", "MODULE_368": "Peptide and AA transporters.", "MODULE_372": "Genes in the cancer module 372.", "MODULE_371": "Genes in the cancer module 371.", "MODULE_373": "Oxidoreductases.", "MODULE_377": "Energy pathways and carbohydrate metabolism.", "MODULE_375": "GPCR signaling pathways (immune and neuro).", "MODULE_37": "Genes in the cancer module 37.", "MODULE_379": "Genes in the cancer module 379.", "MODULE_381": "Genes in the cancer module 381.", "MODULE_385": "Heparin binding.", "MODULE_382": "Peptide hormones.", "MODULE_38": "Placenta genes.", "MODULE_388": "Spliceosome.", "MODULE_387": "Genes in the cancer module 387.", "MODULE_378": "Genes in the cancer module 378.", "MODULE_39": "Genes in the cancer module 39.", "MODULE_389": "Breast cancer expression clusters.", "MODULE_392": "rRNA processing and DNA repair.", "MODULE_395": "Genes in the cancer module 395.", "MODULE_396": "Genes in the cancer module 396.", "MODULE_397": "Genes in the cancer module 397.", "MODULE_4": "Genes in the cancer module 4.", "MODULE_399": "Genes in the cancer module 399.", "MODULE_400": "Genes in the cancer module 400.", "MODULE_40": "Organic acid metabolism.", "MODULE_401": "Genes in the cancer module 401.", "MODULE_402": "Genes in the cancer module 402.", "MODULE_404": "Steroid hormone receptors and binding proteins.", "MODULE_407": "Growth suppressors.", "MODULE_403": "DNA damage response.", "MODULE_408": "Genes in the cancer module 408.", "MODULE_410": "Cell adhesion.", "MODULE_411": "Genes in the cancer module 411.", "MODULE_414": "Genes in the cancer module 414.", "MODULE_412": "Genes in the cancer module 412.", "MODULE_416": "Genes in the cancer module 416.", "MODULE_415": "Genes in the cancer module 415.", "MODULE_417": "Genes in the cancer module 417.", "MODULE_418": "Genes in the cancer module 418.", "MODULE_42": "Genes in the cancer module 42.", "MODULE_419": "Genes in the cancer module 419.", "MODULE_41": "Genes in the cancer module 41.", "MODULE_424": "Genes in the cancer module 424.", "MODULE_421": "Chromatin.", "MODULE_426": "Genes in the cancer module 426.", "MODULE_429": "Genes in the cancer module 429.", "MODULE_43": "Energy pathways.", "MODULE_427": "Genes in the cancer module 427.", "MODULE_431": "Eicosanoid metabolism.", "MODULE_433": "Cytokines and GFs.", "MODULE_439": "Genes in the cancer module 439.", "MODULE_432": "Genes in the cancer module 432.", "MODULE_440": "Urea cycle metabolism.", "MODULE_438": "Intermediate filaments and MT.", "MODULE_430": "Genes in the cancer module 430.", "MODULE_444": "Genes in the cancer module 444.", "MODULE_436": "Genes in the cancer module 436.", "MODULE_44": "Thymus genes.", "MODULE_445": "Genes in the cancer module 445.", "MODULE_447": "Genes in the cancer module 447.", "MODULE_448": "Genes in the cancer module 448.", "MODULE_451": "Genes in the cancer module 451.", "MODULE_453": "Genes in the cancer module 453.", "MODULE_454": "Genes in the cancer module 454.", "MODULE_45": "Whole blood genes.", "MODULE_455": "Genes in the cancer module 455.", "MODULE_457": "Genes in the cancer module 457.", "MODULE_458": "Genes in the cancer module 458.", "MODULE_456": "B lymphoma expression clusters.", "MODULE_462": "Eicosanoid metabolism (and related carboxylic acid biosynthesis).", "MODULE_464": "Oxidoreductases.", "MODULE_465": "Genes in the cancer module 465.", "MODULE_459": "Genes in the cancer module 459.", "MODULE_470": "Genes in the cancer module 470.", "MODULE_474": "Genes in the cancer module 474.", "MODULE_471": "Genes in the cancer module 471.", "MODULE_46": "Genes in the cancer module 46.", "MODULE_478": "Genes in the cancer module 478.", "MODULE_47": "ECM and collagens.", "MODULE_481": "Genes in the cancer module 481.", "MODULE_480": "Breast cancer expression clusters.", "MODULE_484": "Genes in the cancer module 484.", "MODULE_48": "Genes in the cancer module 48.", "MODULE_485": "Genes in the cancer module 485.", "MODULE_489": "Genes in the cancer module 489.", "MODULE_488": "Growth inhibitory genes.", "MODULE_486": "Genes in the cancer module 486.", "MODULE_491": "Genes in the cancer module 491.", "MODULE_49": "Genes in the cancer module 49.", "MODULE_492": "Genes in the cancer module 492.", "MODULE_495": "Genes in the cancer module 495.", "MODULE_493": "Genes in the cancer module 493.", "MODULE_497": "CNS development.", "MODULE_50": "Genes in the cancer module 50.", "MODULE_500": "Genes in the cancer module 500.", "MODULE_501": "Genes in the cancer module 501.", "MODULE_505": "Steroid hormone and heme metabolism.", "MODULE_509": "Genes in the cancer module 509.", "MODULE_503": "Genes in the cancer module 503.", "MODULE_5": "Lung genes.", "MODULE_51": "Genes in the cancer module 51.", "MODULE_512": "Muscle genes.", "MODULE_514": "Genes in the cancer module 514.", "MODULE_516": "Genes in the cancer module 516.", "MODULE_511": "Genes in the cancer module 511.", "MODULE_519": "Oxidoreductases.", "MODULE_521": "T-cell proliferation genes.", "MODULE_524": "Actin cytoskeleton binding.", "MODULE_522": "Immune response genes.", "MODULE_528": "Genes in the cancer module 528.", "MODULE_525": "Genes in the cancer module 525.", "MODULE_52": "Cell line expressed genes.", "MODULE_530": "ROS (glutathione, ox stress).", "MODULE_533": "Genes in the cancer module 533.", "MODULE_537": "Anti-apoptosis.", "MODULE_539": "Genes in the cancer module 539.", "MODULE_534": "Genes in the cancer module 534.", "MODULE_532": "Blood cells and cancer expression clusters.", "MODULE_53": "Cell line expressed genes.", "MODULE_540": "Iron ion homeostasis.", "MODULE_543": "Annexin, MHCII, and lectins.", "MODULE_54": "Cell cycle (expression cluster).", "MODULE_544": "Genes in the cancer module 544.", "MODULE_545": "IL-1 signaling.", "MODULE_547": "Genes in the cancer module 547.", "MODULE_557": "Genes in the cancer module 557.", "MODULE_552": "Chromatin and nucleosomes.", "MODULE_56": "Cell cycle (KEGG, GenMapp).", "MODULE_560": "Genes in the cancer module 560.", "MODULE_562": "MMPs.", "MODULE_563": "Genes in the cancer module 563.", "MODULE_55": "Genes in the cancer module 55.", "MODULE_568": "Genes in the cancer module 568.", "MODULE_571": "Genes in the cancer module 571.", "MODULE_567": "Genes in the cancer module 567.", "MODULE_573": "Cell cycle regulators and carbohydrate transporters.", "MODULE_57": "Genes in the cancer module 57.", "MODULE_575": "Complement and cAMP signaling.", "MODULE_58": "Genes in the cancer module 58.", "MODULE_59": "Genes in the cancer module 59.", "MODULE_576": "Genes in the cancer module 576.", "MODULE_61": "Genes in the cancer module 61.", "MODULE_62": "Genes in the cancer module 62.", "MODULE_65": "Genes in the cancer module 65.", "MODULE_6": "Trachea genes.", "MODULE_68": "Genes in the cancer module 68.", "MODULE_63": "Porins / transporters.", "MODULE_60": "Heart genes.", "MODULE_67": "Genes in the cancer module 67.", "MODULE_64": "Membranal receptors.", "MODULE_66": "Genes in the cancer module 66.", "MODULE_71": "Genes in the cancer module 71.", "MODULE_70": "Genes in the cancer module 70.", "MODULE_73": "Genes in the cancer module 73.", "MODULE_7": "Genes in the cancer module 7.", "MODULE_77": "Genes in the cancer module 77.", "MODULE_76": "Inflammatory response.", "MODULE_72": "Testis genes.", "MODULE_78": "AA metabolism.", "MODULE_75": "Immune response.", "MODULE_69": "Genes in the cancer module 69.", "MODULE_80": "Genes in the cancer module 80.", "MODULE_79": "Genes in the cancer module 79.", "MODULE_81": "Genes in the cancer module 81.", "MODULE_82": "Genes in the cancer module 82.", "MODULE_8": "Genes in the cancer module 8.", "MODULE_86": "Small monomeric GTPases.", "MODULE_89": "Genes in the cancer module 89.", "MODULE_85": "Genes in the cancer module 85.", "MODULE_83": "Genes in the cancer module 83.", "MODULE_87": "Genes in the cancer module 87.", "MODULE_84": "Immune (humoral) and inflammatory response.", "MODULE_90": "Genes in the cancer module 90.", "MODULE_9": "Genes in the cancer module 9.", "MODULE_91": "Proteasome.", "MODULE_88": "Heart, liver, kidney and pancreas metabolic and xenobiotic response genes.", "MODULE_92": "Secreted signaling molecules.", "MODULE_93": "Oxidoreductases.", "MODULE_96": "Genes in the cancer module 96.", "MODULE_97": "Genes in the cancer module 97.", "MODULE_94": "Signaling.", "GOBP_10_FORMYLTETRAHYDROFOLATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. [GOC:ai]", "GOBP_2FE_2S_CLUSTER_ASSEMBLY": "The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]", "MODULE_95": "Genes in the cancer module 95.", "MODULE_99": "Genes in the cancer module 99.", "MODULE_98": "Genes in the cancer module 98.", "GOBP_2_OXOGLUTARATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. [ISBN:0198506732]", "GOBP_3_PHOSPHOADENOSINE_5_PHOSPHOSULFATE_METABOLIC_PROCESS": "", "GOBP_3_UTR_MEDIATED_MRNA_DESTABILIZATION": "An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. [GOC:dph, GOC:jh]", "GOBP_3_UTR_MEDIATED_MRNA_STABILIZATION": "An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. [GOC:mah, PMID:19029303]", "GOBP_4FE_4S_CLUSTER_ASSEMBLY": "The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster. [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]", "GOBP_4_HYDROXYPROLINE_METABOLIC_PROCESS": "", "GOBP_5S_CLASS_RRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_III": "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter. [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659]", "GOBP_5_PHOSPHORIBOSE_1_DIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. [GOC:ai]", "GOBP_7_METHYLGUANOSINE_CAP_HYPERMETHYLATION": "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation. [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984]", "GOBP_7_METHYLGUANOSINE_RNA_CAPPING": "", "GOBP_ABSCISSION": "", "GOBP_ACETATE_ESTER_METABOLIC_PROCESS": "", "GOBP_ACETYLCHOLINE_SECRETION": "The regulated release of acetylcholine by a cell. [GOC:dph]", "GOBP_ACETATE_ESTER_TRANSPORT": "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie]", "GOBP_ACETYL_COA_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. [GOC:go_curators]", "GOBP_ACETYL_COA_BIOSYNTHETIC_PROCESS_FROM_PYRUVATE": "", "GOBP_ACIDIC_AMINO_ACID_TRANSPORT": "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_ACINAR_CELL_DIFFERENTIATION": "", "GOBP_ACETYL_COA_METABOLIC_PROCESS": "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. [ISBN:0198547684]", "GOBP_ACROSOMAL_VESICLE_EXOCYTOSIS": "The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction. [GOC:dph]", "GOBP_ACID_SECRETION": "The controlled release of acid by a cell or a tissue. [GOC:ai]", "GOBP_ACTIN_CROSSLINK_FORMATION": "The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. [GOC:ai]", "GOBP_ACROSOME_ASSEMBLY": "The formation of the acrosome from the spermatid Golgi. [GOC:dph, GOC:hjd, GOC:tb]", "GOBP_ACROSOME_REACTION": "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida. [GOC:dph, PMID:11175768, PMID:21042299, PMID:3886029]", "GOBP_ACTIN_FILAMENT_BASED_MOVEMENT": "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. [GOC:BHF, GOC:mah]", "GOBP_ACTIN_FILAMENT_BASED_TRANSPORT": "The transport of organelles or other particles from one location in the cell to another along actin filaments. [GOC:dos, GOC:dph, GOC:mah, GOC:tb]", "GOBP_ACTIN_FILAMENT_NETWORK_FORMATION": "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments. [GOC:ai]", "GOBP_ACTIN_FILAMENT_SEVERING": "The process in which an actin filament is broken down into smaller filaments. [GOC:ai, PMID:14657234]", "GOBP_ACTIN_FILAMENT_DEPOLYMERIZATION": "Disassembly of actin filaments by the removal of actin monomers from a filament. [GOC:mah]", "GOBP_ACTIN_FILAMENT_BUNDLE_ORGANIZATION": "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. [GOC:dph]", "GOBP_ACTIN_MODIFICATION": "", "GOBP_ACTIN_FILAMENT_BASED_PROCESS": "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. [GOC:mah]", "GOBP_ACTIN_MEDIATED_CELL_CONTRACTION": "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. [GOC:mah]", "GOBP_ACTIN_FILAMENT_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. [GOC:mah]", "GOBP_ACTIN_POLYMERIZATION_DEPENDENT_CELL_MOTILITY": "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell. [GOC:mah, PMID:15773977]", "GOBP_ACTIN_NUCLEATION": "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. [ISBN:0815316194]", "GOBP_ACTIN_MYOSIN_FILAMENT_SLIDING": "The sliding movement of actin thin filaments and myosin thick filaments past each other. [GOC:pf]", "GOBP_ACTIVATED_T_CELL_PROLIFERATION": "The expansion of a T cell population following activation by an antigenic stimulus. [GOC:add, GOC:dph]", "GOBP_ACTIVATION_INDUCED_CELL_DEATH_OF_T_CELLS": "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196, PMID:12414721, PMID:12752672]", "GOBP_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY": "Any process that initiates the activity of the inactive enzyme adenylate cyclase. [GOC:ai]", "GOBP_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION": "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. [GOC:mah]", "GOBP_ACTION_POTENTIAL": "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]", "GOBP_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY": "", "GOBP_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS": "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]", "GOBP_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS_BY_CYTOCHROME_C": "", "GOBP_ACTIVATION_OF_GTPASE_ACTIVITY": "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. [GOC:dph, GOC:mah, GOC:tb]", "GOBP_ACTIVATION_OF_MEIOSIS": "Any process that starts the inactive process of meiosis. [GOC:dph, GOC:tb]", "GOBP_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY": "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. [GOC:jl, PMID:12773372]", "GOBP_ACTIVATION_OF_JANUS_KINASE_ACTIVITY": "", "GOBP_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY": "The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand. [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]", "GOBP_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY": "Any process that initiates the activity of the inactive enzyme protein kinase B. [GOC:pg]", "GOBP_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE": "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]", "GOBP_ACTIVATION_OF_PROTEIN_KINASE_C_ACTIVITY": "", "GOBP_ACTIVATION_OF_IMMUNE_RESPONSE": "Any process that initiates an immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY": "", "GOBP_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY": "Any process that initiates the activity of an inactive protein kinase. [GOC:mah]", "GOBP_ACTOMYOSIN_CONTRACTILE_RING_ORGANIZATION": "A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring. [GOC:mtg_cell_cycle]", "GOBP_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:rl, GOC:signaling]", "GOBP_ACUTE_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS": "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_ACUTE_INFLAMMATORY_RESPONSE": "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_ACTOMYOSIN_STRUCTURE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_ADAPTIVE_IMMUNE_MEMORY_RESPONSE": "An immune response directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response. [GOC:add, PMID:26831526]", "GOBP_ACYLGLYCEROL_TRANSPORT": "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids. [GOC:BHF, GOC:rl]", "GOBP_ACYL_COA_METABOLIC_PROCESS": "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. [ISBN:0198506732]", "GOBP_ACUTE_PHASE_RESPONSE": "An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. [ISBN:0198506732]", "GOBP_ACYLGLYCEROL_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. [GOC:BHF, GOC:rl]", "GOBP_ADENINE_TRANSPORT": "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]", "GOBP_ADAPTIVE_THERMOGENESIS": "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. [PMID:17260010, PMID:20363363]", "GOBP_ADENOHYPOPHYSIS_DEVELOPMENT": "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_ADENOSINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. [GOC:go_curators]", "GOBP_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS": "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831]", "GOBP_ADENOSINE_TRANSPORT": "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_ADENOSINE_TO_INOSINE_EDITING": "The conversion of an adenosine residue to inosine in an RNA molecule by deamination. [PMID:11092837]", "GOBP_ADAPTIVE_IMMUNE_RESPONSE": "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY": "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling]", "GOBP_ADENYLATE_CYCLASE_ACTIVATING_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY": "An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. [GOC:BHF, GOC:mah, GOC:signaling]", "GOBP_ADENYLATE_CYCLASE_INHIBITING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]", "GOBP_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]", "GOBP_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]", "GOBP_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]", "GOBP_ADENYLATE_CYCLASE_INHIBITING_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY": "An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]", "GOBP_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]", "GOBP_ADHERENS_JUNCTION_MAINTENANCE": "The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:mah]", "GOBP_ADHERENS_JUNCTION_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:mah]", "GOBP_ADHERENS_JUNCTION_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah]", "GOBP_ADHESION_OF_SYMBIONT_TO_HOST_CELL": "The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly. [GOC:jl]", "GOBP_ADHESION_OF_SYMBIONT_TO_HOST": "The attachment of a symbiont to its host via either adhesion molecules, general stickiness, or other mechanisms. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:bf, GOC:cc, GOC:dos, GOC:jl]", "GOBP_ADIPONECTIN_ACTIVATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:20536390]", "GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). [GOC:mah, GOC:signaling, ISBN:0815316194]", "GOBP_ADIPOSE_TISSUE_DEVELOPMENT": "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. [GOC:dph]", "GOBP_ADP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate. [GOC:ai]", "GOBP_ADP_TRANSPORT": "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:BHF]", "GOBP_ADRENAL_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. [GOC:dgh]", "GOBP_ADULT_FEEDING_BEHAVIOR": "Feeding behavior in a fully developed and mature organism. [GOC:mah]", "GOBP_ADULT_HEART_DEVELOPMENT": "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. [GOC:bf]", "GOBP_ADULT_BEHAVIOR": "Behavior in a fully developed and mature organism. [GOC:mah, ISBN:0877797099]", "GOBP_AGGREPHAGY": "The selective degradation of protein aggregates by macroautophagy. [GOC:autophagy, GOC:kmv, PMID:18508269, PMID:25062811]", "GOBP_AGGRESOME_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein. [GOC:BHF, GOC:rl, PMID:14675537]", "GOBP_ADULT_LOCOMOTORY_BEHAVIOR": "Locomotory behavior in a fully developed and mature organism. [GOC:ai]", "GOBP_AGGRESSIVE_BEHAVIOR": "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual. [GOC:hjd]", "GOBP_ALANINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. [GOC:go_curators]", "GOBP_AEROBIC_RESPIRATION": "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590]", "GOBP_ALANINE_TRANSPORT": "The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_AIM2_INFLAMMASOME_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form the AIM2 inflammasome complex. [PMID:33467177]", "GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [GOC:ai]", "GOBP_ALCOHOL_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [GOC:ai]", "GOBP_ALDEHYDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. [GOC:ai]", "GOBP_ALDEHYDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O. [GOC:ai]", "GOBP_ALDITOL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. [ISBN:0198506732]", "GOBP_ALCOHOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [ISBN:0198506732]", "GOBP_ALDITOL_PHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. [PMID:30240188]", "GOBP_ALDITOL_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. [ISBN:0198506732]", "GOBP_ALDITOL_METABOLIC_PROCESS": "", "GOBP_ALKALOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). [GOC:lr, ISBN:0122146743]", "GOBP_ALKANESULFONATE_TRANSMEMBRANE_TRANSPORT": "The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical. [PMID:31802112]", "GOBP_ALLANTOIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. [GOC:mah, ISBN:0198547684]", "GOBP_ALPHA_BETA_T_CELL_ACTIVATION": "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:add]", "GOBP_ALPHA_KETOGLUTARATE_TRANSPORT": "The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving an alpha-amino acid. [GOC:TermGenie]", "GOBP_ALPHA_BETA_T_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. [CL:0000789, GOC:ai]", "GOBP_ALPHA_BETA_T_CELL_PROLIFERATION": "The expansion of an alpha-beta T cell population by cell division. [GOC:ai]", "GOBP_AMACRINE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons. [CL:0000561, GOC:bf]", "GOBP_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. [PMID:15538555]", "GOBP_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME": "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. [GOC:krc, PMID:12110900]", "GOBP_AMELOBLAST_DIFFERENTIATION": "", "GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION": "Cell migration that is accomplished by extension and retraction of a pseudopodium. [GOC:dph]", "GOBP_AMELOGENESIS": "The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]", "GOBP_AMIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:curators]", "GOBP_AMIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:curators]", "GOBP_AMINE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]", "GOBP_AMINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]", "GOBP_AMIDE_TRANSPORT": "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, ISBN:0198506732]", "GOBP_AMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]", "GOBP_AMINE_TRANSPORT": "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, ISBN:0198506732]", "GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY": "Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation. [GOC:hjd]", "GOBP_AMINOGLYCAN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. [GOC:ai, ISBN:0198506732]", "GOBP_AMINOGLYCAN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. [GOC:ai, ISBN:0198506732]", "GOBP_AMIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. [GOC:curators]", "GOBP_AMINOGLYCAN_METABOLIC_PROCESS": "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. [GOC:ai, ISBN:0198506732]", "GOBP_AMINOGLYCOSIDE_ANTIBIOTIC_METABOLIC_PROCESS": "", "GOBP_AMINOPHOSPHOLIPID_TRANSLOCATION": "The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. [GOC:pg]", "GOBP_AMINOPHOSPHOLIPID_TRANSPORT": "The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. [GOC:ai]", "GOBP_AMINO_ACID_BETAINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid. [GOC:mah, ISBN:0198506732]", "GOBP_AMINO_ACID_BETAINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. [GOC:mah, ISBN:0198506732]", "GOBP_AMINO_ACID_BETAINE_TRANSPORT": "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_AMINO_ACID_ACTIVATION": "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. [GOC:jl]", "GOBP_AMINO_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. [ISBN:0198506732]", "GOBP_AMINO_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. [GOC:ai]", "GOBP_AMINO_ACID_NEUROTRANSMITTER_REUPTAKE": "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]", "GOBP_AMINO_ACID_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]", "GOBP_AMINO_ACID_SALVAGE": "Any process which produces an amino acid from derivatives of it, without de novo synthesis. [GOC:jl]", "GOBP_AMINO_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. [ISBN:0198506732]", "GOBP_AMINO_ACID_TRANSMEMBRANE_TRANSPORT": "The process in which an amino acid is transported across a membrane. [GOC:dph, GOC:tb]", "GOBP_AMINO_SUGAR_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. [GOC:curators]", "GOBP_AMINO_SUGAR_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. [GOC:curators]", "GOBP_AMINO_ACID_TRANSPORT": "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_AMINO_SUGAR_METABOLIC_PROCESS": "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. [GOC:jl, ISBN:0192801023]", "GOBP_AMMONIUM_HOMEOSTASIS": "Any biological process involved in the maintenance of an internal steady state of ammonium. [GOC:yaf, PMID:12695560]", "GOBP_AMMONIUM_TRANSMEMBRANE_TRANSPORT": "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. [GOC:mah]", "GOBP_AMMONIUM_ION_METABOLIC_PROCESS": "", "GOBP_AMPA_GLUTAMATE_RECEPTOR_CLUSTERING": "The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane. [GOC:BHF, GOC:pr, GOC:sjp, PMID:12796785]", "GOBP_AMP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate. [GOC:go_curators, ISBN:0198506732]", "GOBP_AMP_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate. [ISBN:0198506732]", "GOBP_AMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving AMP, adenosine monophosphate. [GOC:go_curators]", "GOBP_AMP_SALVAGE": "", "GOBP_AMYGDALA_DEVELOPMENT": "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]", "GOBP_AMYLOID_BETA_CLEARANCE_BY_CELLULAR_CATABOLIC_PROCESS": "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation. [GOC:aruk, GOC:bc, PMID:18289866]", "GOBP_AMYLOID_BETA_CLEARANCE_BY_TRANSCYTOSIS": "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:26005850]", "GOBP_AMYLOID_BETA_CLEARANCE": "The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors. [GOC:aruk, GOC:bc, GOC:BHF, PMID:18289866, PMID:19098903, PMID:26005850]", "GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators]", "GOBP_AMYLOID_BETA_METABOLIC_PROCESS": "The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). [GOC:ai]", "GOBP_AMYLOID_FIBRIL_FORMATION": "The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159]", "GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators]", "GOBP_ANAGEN": "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair. [PMID:12230507]", "GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators]", "GOBP_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. [GOC:mah, PMID:15380083, PMID:15840442]", "GOBP_ANATOMICAL_STRUCTURE_ARRANGEMENT": "The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GOC:go_curators]", "GOBP_ANATOMICAL_STRUCTURE_REGRESSION": "The developmental process in which an anatomical structure is destroyed as a part of its normal progression. [GOC:dph]", "GOBP_ANDROGEN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]", "GOBP_ANDROGEN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]", "GOBP_ANDROGEN_METABOLIC_PROCESS": "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]", "GOBP_ANATOMICAL_STRUCTURE_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. [GOC:mah]", "GOBP_ANGIOGENESIS_INVOLVED_IN_CORONARY_VASCULAR_MORPHOGENESIS": "", "GOBP_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY": "A nuclear receptor-mediated signaling pathway initiated by an androgen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription. [GOC:mah]", "GOBP_ANGIOTENSIN_ACTIVATED_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869]", "GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS": "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GOC:dph, GOC:jid, GOC:tb]", "GOBP_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING": "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. [GOC:dph, PMID:15039218]", "GOBP_ANIMAL_ORGAN_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. [GOC:curators]", "GOBP_ANIMAL_ORGAN_FORMATION": "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. [GOC:dph, GOC:jid]", "GOBP_ANIMAL_ORGAN_REGENERATION": "The regrowth of a lost or destroyed animal organ. [GOC:mah]", "GOBP_ANOIKIS": "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix. [GOC:jl, PMID:37667281]", "GOBP_ANTERIOR_COMMISSURE_MORPHOGENESIS": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]", "GOBP_ANTERIOR_HEAD_DEVELOPMENT": "The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure. [GOC:yaf, PMID:14695376, PMID:15857913]", "GOBP_ANTERIOR_POSTERIOR_AXON_GUIDANCE": "The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:dph, GOC:kmv, GOC:tb]", "GOBP_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION": "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION": "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]", "GOBP_ANTEROGRADE_AXONAL_TRANSPORT": "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. [ISBN:0815316194]", "GOBP_ANTEROGRADE_AXONAL_TRANSPORT_OF_MITOCHONDRION": "", "GOBP_ANIMAL_ORGAN_MORPHOGENESIS": "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]", "GOBP_ANTEROGRADE_DENDRITIC_TRANSPORT_OF_NEUROTRANSMITTER_RECEPTOR_COMPLEX": "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse. [GOC:dos]", "GOBP_ANTEROGRADE_DENDRITIC_TRANSPORT": "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites. [ISBN:0815316194]", "GOBP_ANTEROGRADE_NEURONAL_DENSE_CORE_VESICLE_TRANSPORT": "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse. [GOC:kmv, PMID:23358451]", "GOBP_ANTIBACTERIAL_PEPTIDE_PRODUCTION": "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]", "GOBP_ANTIBACTERIAL_INNATE_IMMUNE_RESPONSE": "An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [PMID:16177355, PMID:23006328]", "GOBP_ANTIBACTERIAL_HUMORAL_RESPONSE": "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster. [GOC:go_curators, GOC:mtg_sensu]", "GOBP_ANTIFUNGAL_INNATE_IMMUNE_RESPONSE": "An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [GOC:dph, PMID:22470487]", "GOBP_ANTIFUNGAL_HUMORAL_RESPONSE": "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster. [GOC:go_curators, GOC:mtg_sensu]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_ENDOGENOUS_LIPID_ANTIGEN_VIA_MHC_CLASS_IB": "The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN": "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN": "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. [GOC:add, ISBN:0781735149]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION": "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_ANTIGEN": "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. [GOC:add, ISBN:0781735149, PMID:15771591]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_LIPID_ANTIGEN_VIA_MHC_CLASS_IB": "The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN": "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. [GOC:add, ISBN:0781735149]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN": "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. [GOC:add, ISBN:0781735149, PMID:15771591]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_IB": "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family. [GOC:add, PMID:15928678]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I": "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB": "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. [GOC:add, PMID:15928678, PMID:15928680]", "GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II": "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]", "GOBP_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. [GOC:add]", "GOBP_ANTIMICROBIAL_PEPTIDE_PRODUCTION": "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]", "GOBP_ANTIMICROBIAL_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_ANTIMICROBIAL_PEPTIDE": "An immune response against microbes mediated by anti-microbial peptides in body fluid. [PMID:15761415, PMID:24287494]", "GOBP_ANTRAL_OVARIAN_FOLLICLE_GROWTH": "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "GOBP_ANTIVIRAL_INNATE_IMMUNE_RESPONSE": "A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. [PMID:31006531]", "GOBP_ANTIMICROBIAL_HUMORAL_RESPONSE": "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. [GOC:go_curators, GOC:mtg_sensu]", "GOBP_AORTA_SMOOTH_MUSCLE_TISSUE_MORPHOGENESIS": "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta]", "GOBP_AORTA_DEVELOPMENT": "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]", "GOBP_AORTA_MORPHOGENESIS": "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]", "GOBP_AORTIC_VALVE_MORPHOGENESIS": "The process in which the structure of the aortic valve is generated and organized. [GOC:mtg_heart]", "GOBP_APICAL_PROTEIN_LOCALIZATION": "Any process in which a protein is transported to, or maintained in, apical regions of the cell. [GOC:bf]", "GOBP_APOLIPOPROTEIN_A_I_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, PMID:16443932]", "GOBP_APICAL_JUNCTION_ASSEMBLY": "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]", "GOBP_APOPTOTIC_CELL_CLEARANCE": "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. [GOC:rk, PMID:14685684]", "GOBP_APOPTOTIC_CHROMOSOME_CONDENSATION": "The compaction of chromatin during apoptosis. [GOC:mah]", "GOBP_APOPTOTIC_DNA_FRAGMENTATION": "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]", "GOBP_APOPTOTIC_PROCESS": "", "GOBP_APOPTOTIC_PROCESS_INVOLVED_IN_HEART_MORPHOGENESIS": "Any apoptotic process that contributes to the shaping of the heart. [GOC:mtg_apoptosis, GOC:mtg_heart]", "GOBP_APOPTOTIC_MITOCHONDRIAL_CHANGES": "The morphological and physiological alterations undergone by mitochondria during apoptosis. [GOC:mah, GOC:mtg_apoptosis]", "GOBP_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT": "Any apoptotic process that is involved in anatomical structure development. [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie]", "GOBP_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS": "Any apoptotic process that contributes to the shaping of an anatomical structure. [GOC:dph, GOC:mtg_apoptosis]", "GOBP_APOPTOTIC_PROCESS_IN_BONE_MARROW_CELL": "The apoptotic process in cells in the bone marrow. [GOC:mah, GOC:mtg_apoptosis, PMID:17063141]", "GOBP_ARACHIDONIC_ACID_METABOLIC_PROCESS": "", "GOBP_ARACHIDONIC_ACID_SECRETION": "", "GOBP_ARF_PROTEIN_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette in which a small monomeric GTPase of the ARF subfamily relays a signal. [GOC:mah]", "GOBP_APPENDAGE_DEVELOPMENT": "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. [GOC:jid, GOC:rc]", "GOBP_APPENDAGE_MORPHOGENESIS": "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. [ISBN:0582227089]", "GOBP_ARGININE_CATABOLIC_PROCESS": "", "GOBP_ARGININE_BIOSYNTHETIC_PROCESS": "", "GOBP_APOPTOTIC_SIGNALING_PATHWAY": "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis]", "GOBP_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). [GOC:go_curators]", "GOBP_ARGININE_METABOLIC_PROCESS": "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:go_curators]", "GOBP_AROMATIC_AMINO_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). [GOC:go_curators]", "GOBP_AROMATIC_AMINO_ACID_TRANSPORT": "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_ARTERIAL_ENDOTHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION": "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. [GOC:mah, PMID:16959963, PMID:18640983]", "GOBP_ARTERY_DEVELOPMENT": "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. [GOC:ai]", "GOBP_ASCENDING_AORTA_DEVELOPMENT": "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]", "GOBP_ARTICULAR_CARTILAGE_DEVELOPMENT": "The process whose specific outcome is the progression of articular cartilage over time, from its formation to the mature structure. [PMID:20097540, PMID:20679519]", "GOBP_ARTERY_MORPHOGENESIS": "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. [GOC:dsf, PMID:16740480]", "GOBP_ASPARAGINE_METABOLIC_PROCESS": "", "GOBP_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS": "", "GOBP_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS": "", "GOBP_ASPARTATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. [GOC:go_curators, ISBN:0198506732]", "GOBP_ASPARTATE_TRANSMEMBRANE_TRANSPORT": "The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:go_curators, ISBN:0198506732]", "GOBP_ASSOCIATIVE_LEARNING": "Learning by associating a stimulus (the cause) with a particular outcome (the effect). [ISBN:0582227089]", "GOBP_ASTRAL_MICROTUBULE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. [GOC:mah]", "GOBP_ASTROCYTE_CELL_MIGRATION": "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord. [CL:0000127, GOC:go_curators]", "GOBP_ASTROCYTE_ACTIVATION": "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813]", "GOBP_ASTROCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. [GOC:vp, PMID:15139015]", "GOBP_ASTROCYTE_DEVELOPMENT": "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. [GOC:dgh, GOC:ef]", "GOBP_ASYMMETRIC_CELL_DIVISION": "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. [PMID:11672519]", "GOBP_ASYMMETRIC_NEUROBLAST_DIVISION": "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. [GOC:dph]", "GOBP_ATF6_MEDIATED_UNFOLDED_PROTEIN_RESPONSE": "The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. [GOC:bf, GOC:PARL, PMID:22013210]", "GOBP_ATP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators, ISBN:0198506732]", "GOBP_ATP_EXPORT": "The directed movement of ATP out of a cell or organelle. [GO_REF:0000074, GOC:TermGenie, PMID:24286344]", "GOBP_ATP_TRANSPORT": "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_ATP_SYNTHESIS_COUPLED_ELECTRON_TRANSPORT": "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. [ISBN:0716731363]", "GOBP_ATP_METABOLIC_PROCESS": "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]", "GOBP_ATRIAL_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION": "The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF]", "GOBP_ATRIAL_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT": "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_ATRIAL_CARDIAC_MUSCLE_CELL_TO_AV_NODE_CELL_COMMUNICATION": "The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_ATRIAL_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS": "The process in which the anatomical structure of cardiac atrium muscle is generated and organized. [GOC:devbiol]", "GOBP_ATRIAL_SEPTUM_DEVELOPMENT": "The progression of the atrial septum over time, from its initial formation to the mature structure. [GOC:mtg_heart]", "GOBP_ATRIAL_SEPTUM_MORPHOGENESIS": "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. [GOC:dph, GOC:mtg_heart]", "GOBP_ATRIOVENTRICULAR_NODE_DEVELOPMENT": "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. [GOC:mtg_heart]", "GOBP_ATRIOVENTRICULAR_CANAL_DEVELOPMENT": "The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle. [GOC:BHF, GOC:gr, PMID:14701881, UBERON:0002087, ZFA:0001315]", "GOBP_ATRIOVENTRICULAR_VALVE_FORMATION": "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]", "GOBP_ATRIOVENTRICULAR_VALVE_DEVELOPMENT": "The progression of the atrioventricular valve over time, from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_ATTACHMENT_OF_GPI_ANCHOR_TO_PROTEIN": "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain. [ISBN:0879695595]", "GOBP_ATTACHMENT_OF_MITOTIC_SPINDLE_MICROTUBULES_TO_KINETOCHORE": "The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in mitosis. [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]", "GOBP_AUDITORY_RECEPTOR_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph]", "GOBP_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS": "Any process that alters the size or shape of an auditory receptor cell. [GOC:dph, GOC:tb]", "GOBP_AUTOCRINE_SIGNALING": "Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type. [GOC:bf, ISBN:3527303782]", "GOBP_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE": "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. [GOC:vw, PMID:10322137]", "GOBP_AUTOPHAGIC_CELL_DEATH": "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells. [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517]", "GOBP_AUTOPHAGOSOME_LYSOSOME_FUSION": "The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome. [PMID:28077293]", "GOBP_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. [FMA:9905, GOC:jid, GOC:sr]", "GOBP_AUTOPHAGOSOME_MATURATION": "Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. [GOC:autophagy, GOC:lf, PMID:28077293]", "GOBP_AUTOPHAGOSOME_MEMBRANE_DOCKING": "The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. [GOC:autophagy, GOC:mah]", "GOBP_AUTOPHAGY_OF_PEROXISOME": "The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions. [GOC:autophagy, PMID:10547367, PMID:20083110]", "GOBP_AUTOPHAGOSOME_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024]", "GOBP_AUTOPHAGY_OF_MITOCHONDRION": "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]", "GOBP_AV_NODE_CELL_TO_BUNDLE_OF_HIS_CELL_COMMUNICATION": "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_AUTOSOME_GENOMIC_IMPRINTING": "The establishment of epigenetic modifications (imprints) in autosomal (non-sexual) chromosomes during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation. [PMID:31782494]", "GOBP_AV_NODE_CELL_TO_BUNDLE_OF_HIS_CELL_SIGNALING": "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_AXIAL_MESODERM_DEVELOPMENT": "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. [GOC:dgh]", "GOBP_AXIS_ELONGATION": "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_AXIS_SPECIFICATION": "The establishment, maintenance and elaboration of a pattern along a line or around a point. [GOC:dph, GOC:go_curators, GOC:isa_complete]", "GOBP_AXONAL_FASCICULATION": "The collection of axons into a bundle of rods, known as a fascicle. [GOC:dgh]", "GOBP_AXONAL_TRANSPORT_OF_MITOCHONDRION": "The directed movement of mitochondria along microtubules in nerve cell axons. [GOC:ai]", "GOBP_AXONEMAL_CENTRAL_APPARATUS_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus. [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:9295136]", "GOBP_AXONAL_TRANSPORT": "The directed movement of organelles or molecules along microtubules in axons. [ISBN:0815316194]", "GOBP_AXONOGENESIS_INVOLVED_IN_INNERVATION": "The neurite development process that generates a long process of a neuron, as it invades a target tissue. [GOC:dph, GOC:sart]", "GOBP_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. [GOC:cilia, GOC:mah, PMID:19052621]", "GOBP_AXONEME_ASSEMBLY": "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]", "GOBP_AXON_CHOICE_POINT_RECOGNITION": "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth. [PMID:10218152]", "GOBP_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM": "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. [GOC:dgh]", "GOBP_AXON_MIDLINE_CHOICE_POINT_RECOGNITION": "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline. [PMID:11376484]", "GOBP_AXON_EXTENSION": "Long distance growth of a single axon process involved in cellular development. [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]", "GOBP_AXO_DENDRITIC_PROTEIN_TRANSPORT": "The directed movement of proteins along microtubules in neuron projections. [ISBN:0815316194]", "GOBP_AXON_DEVELOPMENT": "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation). [GOC:dph, GOC:pg, GOC:pr]", "GOBP_BARBED_END_ACTIN_FILAMENT_CAPPING": "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. [ISBN:071673706X]", "GOBP_AZOLE_TRANSMEMBRANE_TRANSPORT": "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]", "GOBP_AXO_DENDRITIC_TRANSPORT": "The directed movement of organelles or molecules along microtubules in neuron projections. [ISBN:0815316194]", "GOBP_BASEMENT_MEMBRANE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. [GOC:mah]", "GOBP_BASE_CONVERSION_OR_SUBSTITUTION_EDITING": "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s). [PMID:11092837]", "GOBP_BASEMENT_MEMBRANE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. [GOC:mah]", "GOBP_BASE_EXCISION_REPAIR_AP_SITE_FORMATION": "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. [ISBN:0815316194]", "GOBP_BASE_EXCISION_REPAIR": "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. [ISBN:0815316194]", "GOBP_BASE_EXCISION_REPAIR_GAP_FILLING": "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template. [ISBN:1550091131]", "GOBP_BASIC_AMINO_ACID_TRANSPORT": "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_BASOLATERAL_PROTEIN_SECRETION": "The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base. [GOC:ha, PMID:27404358]", "GOBP_BEHAVIORAL_RESPONSE_TO_COCAINE": "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. [GOC:jid]", "GOBP_BEHAVIORAL_RESPONSE_TO_ETHANOL": "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus. [GOC:jid]", "GOBP_BEHAVIORAL_RESPONSE_TO_PAIN": "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid]", "GOBP_BEHAVIORAL_RESPONSE_TO_NICOTINE": "Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. [GOC:bf, ISBN:0198506732]", "GOBP_BICARBONATE_TRANSPORT": "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_BERGMANN_GLIAL_CELL_DIFFERENTIATION": "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph, PMID:10375501]", "GOBP_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. [GOC:jl]", "GOBP_BEHAVIOR": "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]", "GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT": "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]", "GOBP_BILE_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC:go_curators]", "GOBP_BILE_ACID_SECRETION": "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. [GOC:ecd]", "GOBP_BILE_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:go_curators]", "GOBP_BILE_ACID_SIGNALING_PATHWAY": "The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:12016314, PMID:36409000]", "GOBP_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA": "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. [GOC:dph, ISBN:0878932437]", "GOBP_BIOLOGICAL_PHASE": "A distinct period or stage in a biological process or cycle. [GOC:jl]", "GOBP_BIOGENIC_AMINE_METABOLIC_PROCESS": "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. [GOC:jl, ISBN:0395825172]", "GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERACTION_WITH_HOST": "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. [GOC:cc]", "GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERACTION_WITH_SYMBIONT": "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. [GOC:cc]", "GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS": "Any process in which an organism has an effect on an organism of the same species. [GOC:ai]", "GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_SYMBIOTIC_INTERACTION": "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts. [GOC:cc, PMID:31257129]", "GOBP_BLASTOCYST_DEVELOPMENT": "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence. [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "GOBP_BIOMINERAL_TISSUE_DEVELOPMENT": "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. [PMID:15132736]", "GOBP_BLASTOCYST_FORMATION": "The initial formation of a blastocyst from a solid ball of cells known as a morula. [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "GOBP_BLASTOCYST_GROWTH": "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "GOBP_BLASTODERM_SEGMENTATION": "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]", "GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS": "Any process evolved to enable an interaction with an organism of a different species. [GOC:cc]", "GOBP_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION": "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. [GOC:add, GOC:mah, GOC:pde, PMID:26018600]", "GOBP_BLEB_ASSEMBLY": "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]", "GOBP_BLOOD_COAGULATION_INTRINSIC_PATHWAY": "A protein activation cascade that initiates blood coagulation, triggered when Factor XII, prekallikrein (PK) and high-molecular-weight kininogen  (HK) assemble on a suitable surface or polymer. This results in the reciprocal activation of factor XII to Factor XIIa by kallikrein, and PK to kallikrein by Factor XIIa. The resulting generation of Factor XIIa activates Factor XI to Factor XIa, which then converts Factor IX to Factor IXa. Factor IXa converts Factor X to Xa. Factor Xa then initiates the common pathway. [GOC:add, GOC:mah, GOC:pde, PMID:26018600]", "GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_PROLIFERATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS": "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis. [GOC:dph, GOC:tb, PMID:16391003]", "GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION": "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. [PMID:11166264]", "GOBP_BLOOD_VESSEL_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. [GOC:dph]", "GOBP_BODY_FLUID_SECRETION": "The controlled release of a fluid by a cell or tissue in an animal. [GOC:ai, GOC:dph, GOC:mah, GOC:tb]", "GOBP_BLOOD_VESSEL_REMODELING": "The reorganization or renovation of existing blood vessels. [GOC:hjd]", "GOBP_BONE_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dos]", "GOBP_BODY_MORPHOGENESIS": "The process in which the anatomical structures of the soma are generated and organized. [GOC:ems, ISBN:0140512888]", "GOBP_BLOOD_VESSEL_MORPHOGENESIS": "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. [GOC:jid]", "GOBP_BONE_MARROW_DEVELOPMENT": "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. [GOC:add, ISBN:0781735149]", "GOBP_BONE_GROWTH": "The increase in size or mass of a bone that contributes to the shaping of that bone. [GOC:dos]", "GOBP_BONE_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. [GOC:dph, GOC:mah]", "GOBP_BONE_DEVELOPMENT": "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. [GOC:dph]", "GOBP_BONE_MINERALIZATION_INVOLVED_IN_BONE_MATURATION": "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state. [GOC:bf, GOC:BHF]", "GOBP_BONE_MINERALIZATION": "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354]", "GOBP_BONE_MORPHOGENESIS": "The process in which bones are generated and organized. [GOC:dph]", "GOBP_BONE_REMODELING": "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. [GOC:curators]", "GOBP_BONE_TRABECULA_FORMATION": "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]", "GOBP_BONE_TRABECULA_MORPHOGENESIS": "The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:BHF, GOC:dph, GOC:vk]", "GOBP_BONE_RESORPTION": "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. [GOC:mah, PMID:10968780]", "GOBP_BOX_C_D_SNORNP_ASSEMBLY": "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. [GOC:krc]", "GOBP_BRADYKININ_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin. [GOC:BHF, GOC:rl]", "GOBP_BRAINSTEM_DEVELOPMENT": "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. [GOC:dph]", "GOBP_BRAIN_DERIVED_NEUROTROPHIC_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands. [GOC:mah]", "GOBP_BRAIN_MORPHOGENESIS": "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dgh, GOC:jid]", "GOBP_BRANCHED_CHAIN_AMINO_ACID_BIOSYNTHETIC_PROCESS": "", "GOBP_BRANCHED_CHAIN_AMINO_ACID_CATABOLIC_PROCESS": "", "GOBP_BRANCHED_CHAIN_AMINO_ACID_TRANSPORT": "The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. [GOC:ai, GOC:bf]", "GOBP_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. [GOC:ai]", "GOBP_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS": "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. [GOC:dph, PMID:16916377]", "GOBP_BRANCHING_INVOLVED_IN_PROSTATE_GLAND_MORPHOGENESIS": "The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. [GOC:dph]", "GOBP_BRANCHING_INVOLVED_IN_BLOOD_VESSEL_MORPHOGENESIS": "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. [GOC:dph]", "GOBP_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS": "The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph]", "GOBP_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS": "The process in which the branching structure of the salivary gland is generated and organized. [GOC:dph]", "GOBP_BRANCHIOMOTOR_NEURON_AXON_GUIDANCE": "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587]", "GOBP_BRANCH_ELONGATION_OF_AN_EPITHELIUM": "The growth process in which a branch increases in length from its base to its tip. [GOC:dph]", "GOBP_BRANCH_ELONGATION_INVOLVED_IN_MAMMARY_GLAND_DUCT_BRANCHING": "The developmental growth process in which a branch of a mammary gland duct elongates. [GOC:dph]", "GOBP_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE": "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. [GOC:dgh, GOC:dph, GOC:jid]", "GOBP_BRANCHING_MORPHOGENESIS_OF_A_NERVE": "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). [GOC:dgh, GOC:dph, GOC:jid]", "GOBP_BRONCHUS_DEVELOPMENT": "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs. [GOC:dph]", "GOBP_BRONCHIOLE_DEVELOPMENT": "", "GOBP_BRUSH_BORDER_ASSEMBLY": "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border. [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409]", "GOBP_BROWN_FAT_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [PMID:12588810]", "GOBP_BUD_ELONGATION_INVOLVED_IN_LUNG_BRANCHING": "The process in which a bud in the lung grows out from the point where it is formed. [GOC:dph, GOC:mtg_lung]", "GOBP_B_1_B_CELL_DIFFERENTIATION": "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. [GOC:add, ISBN:0781735149]", "GOBP_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_SIGNALING": "Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION": "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_B_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]", "GOBP_B_CELL_CHEMOTAXIS": "The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [CL:0000236, GOC:BHF]", "GOBP_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:jal]", "GOBP_B_CELL_ACTIVATION": "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]", "GOBP_B_CELL_LINEAGE_COMMITMENT": "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell. [GOC:add, ISBN:0781735149]", "GOBP_B_CELL_HOMEOSTASIS": "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, ISBN:0781735149, PMID:12956429]", "GOBP_B_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah]", "GOBP_B_CELL_PROLIFERATION_INVOLVED_IN_IMMUNE_RESPONSE": "The expansion of a B cell population by cell division following B cell activation during an immune response. [GOC:jal]", "GOBP_B_CELL_PROLIFERATION": "The expansion of a B cell population by cell division. Follows B cell activation. [GOC:jl]", "GOBP_B_CELL_MEDIATED_IMMUNITY": "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. [GOC:ai]", "GOBP_B_CELL_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. [GOC:add]", "GOBP_CADMIUM_ION_TRANSMEMBRANE_TRANSPORT": "A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_C4_DICARBOXYLATE_TRANSPORT": "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. [GOC:krc, GOC:mah]", "GOBP_CALCITONIN_FAMILY_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]", "GOBP_C21_STEROID_HORMONE_METABOLIC_PROCESS": "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. [GOC:ai]", "GOBP_CALCINEURIN_MEDIATED_SIGNALING": "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]", "GOBP_CALCIUM_ACTIVATED_PHOSPHOLIPID_SCRAMBLING": "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. [GOC:krc, PMID:23532839]", "GOBP_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES": "", "GOBP_CALCIUM_IMPORT_INTO_THE_MITOCHONDRION": "A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix. [GOC:vw]", "GOBP_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES": "", "GOBP_CALCIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:mah, PMID:2145281]", "GOBP_CALCIUM_ION_IMPORT": "The directed movement of calcium ions into a cell or organelle. [GOC:mah]", "GOBP_CALCIUM_ION_IMPORT_INTO_SARCOPLASMIC_RETICULUM": "The directed movement of calcium ions into a sarcoplasmic reticulum. [GOC:BHF, PMID:17286271]", "GOBP_CALCIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]", "GOBP_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER": "The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. [GOC:curators]", "GOBP_CALCIUM_ION_REGULATED_EXOCYTOSIS": "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. [GOC:go_curators]", "GOBP_CALCIUM_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. [GOC:ceb, GOC:jid, GOC:mah]", "GOBP_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT_VIA_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL": "A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel. [GOC:dph]", "GOBP_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL": "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. [GOC:vw]", "GOBP_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL": "The directed movement of calcium ions (Ca2+) into the cytosol. [GOC:dph, GOC:tb]", "GOBP_CALMODULIN_DEPENDENT_KINASE_SIGNALING_PATHWAY": "", "GOBP_CALCIUM_ION_TRANSPORT": "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT": "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_CALCIUM_MEDIATED_SIGNALING": "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]", "GOBP_CAMERA_TYPE_EYE_MORPHOGENESIS": "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. [GOC:jid, GOC:mtg_sensu]", "GOBP_CAMKK_AMPK_SIGNALING_CASCADE": "The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity. [GOC:dph, GOC:pad, GOC:PARL, PMID:23010169, PMID:24709372]", "GOBP_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_CAMP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [ISBN:0198506732]", "GOBP_CAMP_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [ISBN:0198506732]", "GOBP_CAMP_MEDIATED_SIGNALING": "An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]", "GOBP_CAMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [GOC:go_curators]", "GOBP_CANNABINOID_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. [GOC:bf, GOC:jc, GOC:signaling, Wikipedia:Cannabinoid]", "GOBP_CAMP_PKA_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell. [PMID:23209152]", "GOBP_CAP_DEPENDENT_TRANSLATIONAL_INITIATION": "The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation. [PMID:17284590, PMID:19604130]", "GOBP_CARBOHYDRATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [ISBN:0198506732]", "GOBP_CARBOHYDRATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [ISBN:0198506732]", "GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT": "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:bf, GOC:jl, GOC:TermGenie]", "GOBP_CANONICAL_WNT_SIGNALING_PATHWAY": "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [PMID:11532397, PMID:19619488]", "GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of carbohydrate derivative. [GOC:TermGenie]", "GOBP_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs). [GOC:bf, PMID:12773372, PMID:34659217]", "GOBP_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. [GOC:TermGenie]", "GOBP_CARBOHYDRATE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]", "GOBP_CARBOHYDRATE_HOMEOSTASIS": "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. [GOC:mah]", "GOBP_CARBOHYDRATE_MEDIATED_SIGNALING": "The series of molecular signals mediated by the detection of carbohydrate. [GOC:sm]", "GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS": "The chemical reactions and pathways involving carbohydrate derivative. [GOC:TermGenie]", "GOBP_CARBOHYDRATE_PHOSPHORYLATION": "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. [ISBN:0198506732]", "GOBP_CARBON_CATABOLITE_REGULATION_OF_TRANSCRIPTION": "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. [GOC:go_curators, GOC:mah, PMID:18359269, PMID:9618445]", "GOBP_CARBOHYDRATE_TRANSPORT": "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. [GOC:ai]", "GOBP_CARBON_DIOXIDE_TRANSPORT": "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_CARDIAC_ATRIUM_MORPHOGENESIS": "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. [GOC:mtg_heart]", "GOBP_CARBOHYDRATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]", "GOBP_CARDIAC_ATRIUM_DEVELOPMENT": "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. [GOC:mtg_heart]", "GOBP_CARDIAC_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. [GOC:devbiol]", "GOBP_CARDIAC_CELL_FATE_COMMITMENT": "The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. [GOC:mtg_heart]", "GOBP_CARDIAC_CHAMBER_FORMATION": "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. [GOC:mtg_heart]", "GOBP_CARDIAC_CHAMBER_DEVELOPMENT": "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. [GOC:mtg_heart]", "GOBP_CARDIAC_CHAMBER_MORPHOGENESIS": "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. [GOC:mtg_heart]", "GOBP_CARDIAC_CONDUCTION": "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. [GOC:dph]", "GOBP_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. [GOC:mtg_heart]", "GOBP_CARDIAC_FIBROBLAST_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]", "GOBP_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION": "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351]", "GOBP_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS": "The process in which the left cardiac ventricle is generated and organized. [GOC:mtg_heart]", "GOBP_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "An action potential that occurs in a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_CARDIAC_MUSCLE_CELL_CARDIAC_MUSCLE_CELL_ADHESION": "The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL_INVOLVED_IN_CONTRACTION": "An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_CARDIAC_MUSCLE_CELL_CONTRACTION": "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_CARDIAC_MUSCLE_CELL_DIFFERENTIATION": "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. [GOC:devbiol, GOC:mtg_heart]", "GOBP_CARDIAC_MUSCLE_CELL_FATE_COMMITMENT": "The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. [GOC:mtg_heart]", "GOBP_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION": "The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF]", "GOBP_CARDIAC_MUSCLE_CELL_MYOBLAST_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. [GOC:dph, GOC:tb]", "GOBP_CARDIAC_MUSCLE_MYOBLAST_PROLIFERATION": "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]", "GOBP_CARDIAC_MUSCLE_CELL_PROLIFERATION": "The expansion of a cardiac muscle cell population by cell division. [GOC:dph, GOC:rph, PMID:11161571]", "GOBP_CARDIAC_MUSCLE_TISSUE_REGENERATION": "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. [GOC:dph]", "GOBP_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS": "The process in which the anatomical structures of cardiac muscle tissue are generated and organized. [GOC:devbiol]", "GOBP_CARDIAC_MUSCLE_CONTRACTION": "Muscle contraction of cardiac muscle tissue. [GOC:dph]", "GOBP_CARDIAC_MYOFIBRIL_ASSEMBLY": "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. [GOC:devbiol]", "GOBP_CARDIAC_NEURAL_CREST_CELL_DEVELOPMENT_INVOLVED_IN_OUTFLOW_TRACT_MORPHOGENESIS": "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. [GOC:dph, GOC:mtg_heart]", "GOBP_CARDIAC_NEURAL_CREST_CELL_DIFFERENTIATION_INVOLVED_IN_HEART_DEVELOPMENT": "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. [GOC:dph, GOC:mtg_heart, PMID:19705442]", "GOBP_CARDIAC_NEURAL_CREST_CELL_MIGRATION_INVOLVED_IN_OUTFLOW_TRACT_MORPHOGENESIS": "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. [GOC:mtg_heart]", "GOBP_CARDIAC_PACEMAKER_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]", "GOBP_CARDIAC_PACEMAKER_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]", "GOBP_CARDIAC_SEPTUM_CELL_DIFFERENTIATION": "The process in which an endocardial cushion cell becomes a cell of a cardiac septum. [GOC:mtg_heart]", "GOBP_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS": "The process in which the right cardiac ventricle is generated and organized. [GOC:mtg_heart]", "GOBP_CARDIAC_SEPTUM_DEVELOPMENT": "The progression of a cardiac septum over time, from its initial formation to the mature structure. [GOC:mtg_heart]", "GOBP_CARDIAC_SEPTUM_MORPHOGENESIS": "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. [GOC:dph, GOC:mtg_heart]", "GOBP_CARDIAC_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers. [GOC:mtg_heart]", "GOBP_CARDIAC_VENTRICLE_FORMATION": "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]", "GOBP_CARDIAC_VENTRICLE_DEVELOPMENT": "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]", "GOBP_CARDIOBLAST_PROLIFERATION": "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:mtg_heart]", "GOBP_CARDIOBLAST_DIFFERENTIATION": "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:go_curators]", "GOBP_CARDIAC_VENTRICLE_MORPHOGENESIS": "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]", "GOBP_CARDIOLIPIN_ACYL_CHAIN_REMODELING": "", "GOBP_CARDIOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. [GOC:bf]", "GOBP_CARDIOLIPIN_BIOSYNTHETIC_PROCESS": "", "GOBP_CARDIOLIPIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. [GOC:mah]", "GOBP_CARNITINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732]", "GOBP_CARTILAGE_CONDENSATION": "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. [ISBN:0878932437]", "GOBP_CARNITINE_TRANSMEMBRANE_TRANSPORT": "", "GOBP_CARNITINE_TRANSPORT": "The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:ai]", "GOBP_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS": "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. [GOC:dph]", "GOBP_CARTILAGE_MORPHOGENESIS": "The process in which the anatomical structures of cartilage are generated and organized. [GOC:dph]", "GOBP_CARTILAGE_DEVELOPMENT": "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:cjm, PMID:23251424]", "GOBP_CATECHOLAMINE_SECRETION": "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:ai, GOC:ef]", "GOBP_CATECHOLAMINE_UPTAKE_INVOLVED_IN_SYNAPTIC_TRANSMISSION": "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]", "GOBP_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. [GOC:go_curators]", "GOBP_CATECHOLAMINE_UPTAKE": "The directed movement of catecholamine into a cell. [GOC:dph, GOC:tb]", "GOBP_CATECHOL_CONTAINING_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. [GOC:go_curators]", "GOBP_CATECHOLAMINE_TRANSPORT": "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:ai, ISBN:0198506732]", "GOBP_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. [GOC:sm, ISBN:0198547684]", "GOBP_CAVEOLA_ASSEMBLY": "", "GOBP_CAVEOLIN_MEDIATED_ENDOCYTOSIS": "An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers. [GOC:BHF, GOC:mah, PMID:17318224, PMID:18498251, PMID:8970738, PMID:9234965]", "GOBP_CD40_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mtg_signal, GOC:signaling, PMID:11348017]", "GOBP_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION": "", "GOBP_CD4_POSITIVE_ALPHA_BETA_T_CELL_PROLIFERATION": "The expansion of a CD4-positive, alpha-beta T cell population by cell division. [CL:0000624, GOC:BHF]", "GOBP_CD4_POSITIVE_ALPHA_BETA_T_CELL_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell. [CL:0000624, GOC:BHF]", "GOBP_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION": "The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [CL:0000624, GOC:BHF]", "GOBP_CD4_POSITIVE_CD25_POSITIVE_ALPHA_BETA_REGULATORY_T_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell. [GOC:add, PMID:15207821]", "GOBP_CD8_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell. [ISBN:0781735149]", "GOBP_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION": "The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [CL:0000625, GOC:yaf]", "GOBP_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT": "The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. [ISBN:0781735149]", "GOBP_CD8_POSITIVE_ALPHA_BETA_T_CELL_PROLIFERATION": "The expansion of a CD8-positive, alpha-beta T cell population by cell division. [CL:0000625, GOC:BHF]", "GOBP_CDC42_PROTEIN_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal. [GOC:mah, PMID:18558478]", "GOBP_CDP_CHOLINE_PATHWAY": "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. [ISBN:0471331309, MetaCyc:PWY3O-450]", "GOBP_CDP_DIACYLGLYCEROL_BIOSYNTHETIC_PROCESS": "", "GOBP_CELLULAR_ALDEHYDE_METABOLIC_PROCESS": "", "GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS": "The cellular component assembly that is part of the initial shaping of the component during its developmental progression. [GOC:dph, GOC:tb]", "GOBP_CELLULAR_DETOXIFICATION_OF_ALDEHYDE": "Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:vw, PMID:25656103]", "GOBP_CELLULAR_DEFENSE_RESPONSE": "A defense response that is mediated by cells. [GOC:ebc]", "GOBP_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS": "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb]", "GOBP_CELLULAR_COMPONENT_MAINTENANCE": "The organization process that preserves a cellular component in a stable functional or structural state. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_CELLULAR_GLUCURONIDATION": "", "GOBP_CELLULAR_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. [GOC:jl]", "GOBP_CELLULAR_COMPONENT_DISASSEMBLY": "A cellular process that results in the breakdown of a cellular component. [GOC:isa_complete]", "GOBP_CELLULAR_HYPEROSMOTIC_RESPONSE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. [GOC:mah]", "GOBP_CELLULAR_EXTRAVASATION": "The migration of a leukocyte from the blood vessels into the surrounding tissue. [GOC:jl]", "GOBP_CELLULAR_HYPOTONIC_RESPONSE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. [GOC:mah]", "GOBP_CELLULAR_LIPID_BIOSYNTHETIC_PROCESS": "", "GOBP_CELLULAR_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state at the level of the cell. [GOC:isa_complete, GOC:jl, ISBN:0395825172]", "GOBP_CELLULAR_KETONE_METABOLIC_PROCESS": "", "GOBP_CELLULAR_LIPID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. [GOC:jl]", "GOBP_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS": "", "GOBP_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS": "", "GOBP_CELLULAR_LIPID_METABOLIC_PROCESS": "", "GOBP_CELLULAR_METABOLIC_COMPOUND_SALVAGE": "", "GOBP_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS": "", "GOBP_CELLULAR_PIGMENTATION": "The deposition or aggregation of coloring matter in a cell. [GOC:mtg_MIT_16mar07]", "GOBP_CELLULAR_OXIDANT_DETOXIFICATION": "Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. [GOC:dos, GOC:vw]", "GOBP_CELLULAR_RESPIRATION": "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). [GOC:das, ISBN:0140513590, ISBN:0198506732]", "GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM": "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. [GOC:isa_complete]", "GOBP_CELLULAR_RESPONSE_TO_ACIDIC_PH": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:go_curators, GOC:mah, Wikipedia:PH]", "GOBP_CELLULAR_RESPONSE_TO_ALDEHYDE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus. [GOC:vw, PMID:25656103]", "GOBP_CELLULAR_RESPONSE_TO_ALDOSTERONE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17644563]", "GOBP_CELLULAR_RESPONSE_TO_ACID_CHEMICAL": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. [GOC:go_curators, GOC:mah, Wikipedia:Acid]", "GOBP_CELLULAR_RESPONSE_TO_ALCOHOL": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. [GOC:pr]", "GOBP_CELLULAR_RESPONSE_TO_AMMONIUM_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23509267]", "GOBP_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ALKALOID": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_AMYLOID_BETA": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]", "GOBP_CELLULAR_RESPONSE_TO_ANTIBIOTIC": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ANGIOTENSIN": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. [GO_REF:0000071, GOC:TermGenie, PMID:22982863]", "GOBP_CELLULAR_RESPONSE_TO_ATP": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_BRAIN_DERIVED_NEUROTROPHIC_FACTOR_STIMULUS": "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus. [PMID:21958434]", "GOBP_CELLULAR_RESPONSE_TO_CADMIUM_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_CAFFEINE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_CALCIUM_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_CGMP": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_CAMP": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_COCAINE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_CHOLESTEROL": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_COLD": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:jp]", "GOBP_CELLULAR_RESPONSE_TO_COPPER_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress. [PMID:26653712]", "GOBP_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. [GOC:mah, GOC:yaf]", "GOBP_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_DSRNA": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. [GOC:BHF, GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ETHANOL": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ETHER": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_FATTY_ACID": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_FRUCTOSE_STIMULUS": "", "GOBP_CELLULAR_RESPONSE_TO_GAMMA_RADIATION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_GLUCOCORTICOID_STIMULUS": "", "GOBP_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. [GOC:jl]", "GOBP_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_HISTAMINE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_HEAT": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_HYDROPEROXIDE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [CHEBI:16240, GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_INCREASED_OXYGEN_LEVELS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. [GOC:al]", "GOBP_CELLULAR_RESPONSE_TO_HYPEROXIA": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_INDOLE_3_METHANOL": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus. [GOC:mah, GOC:yaf]", "GOBP_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE": "", "GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_INSULIN_LIKE_GROWTH_FACTOR_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. [PMID:20042609]", "GOBP_CELLULAR_RESPONSE_TO_INTERFERON_ALPHA": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. [GOC:sl]", "GOBP_CELLULAR_RESPONSE_TO_INTERFERON_BETA": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. [GOC:sl]", "GOBP_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]", "GOBP_CELLULAR_RESPONSE_TO_IRON_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_IONIZING_RADIATION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_INTERLEUKIN_1": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_KETONE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. [GOC:pr, GOC:TermGenie]", "GOBP_CELLULAR_RESPONSE_TO_LEAD_ION": "", "GOBP_CELLULAR_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS": "", "GOBP_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. [GOC:yaf]", "GOBP_CELLULAR_RESPONSE_TO_LEUCINE_STARVATION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine. [PMID:19033384]", "GOBP_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_L_GLUTAMATE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25962137]", "GOBP_CELLULAR_RESPONSE_TO_LUTEINIZING_HORMONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_MAGNESIUM_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_L_LEUCINE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_LIPID": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_MACROPHAGE_COLONY_STIMULATING_FACTOR_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. [GOC:yaf, PMID:14687666]", "GOBP_CELLULAR_RESPONSE_TO_MINERALOCORTICOID_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_MANGANESE_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_MURAMYL_DIPEPTIDE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. [GOC:jl]", "GOBP_CELLULAR_RESPONSE_TO_NICOTINE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_NITROSATIVE_STRESS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND": "", "GOBP_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE": "", "GOBP_CELLULAR_RESPONSE_TO_NUTRIENT": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_NUTRIENT_LEVELS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_OXIDISED_LOW_DENSITY_LIPOPROTEIN_PARTICLE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus. [GOC:aruk, GOC:BHF, PMID:20037584, PMID:27607416]", "GOBP_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. [GOC:pr, GOC:TermGenie]", "GOBP_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_PEPTIDE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. [GOC:pr, GOC:TermGenie]", "GOBP_CELLULAR_RESPONSE_TO_PARATHYROID_HORMONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_PEPTIDOGLYCAN": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_PH": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:mah, Wikipedia:PH]", "GOBP_CELLULAR_RESPONSE_TO_POTASSIUM_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. [GOC:yaf]", "GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. [GOC:pr, GOC:TermGenie]", "GOBP_CELLULAR_RESPONSE_TO_PROGESTERONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_PEPTIDE_HORMONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_PURINE_CONTAINING_COMPOUND": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. [GOC:sl, GOC:TermGenie, PMID:22504638]", "GOBP_CELLULAR_RESPONSE_TO_RADIATION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_RETINOIC_ACID": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_SALT_STRESS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_SALT": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. [GOC:mls, GOC:TermGenie, PMID:16666921]", "GOBP_CELLULAR_RESPONSE_TO_SODIUM_ARSENITE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18674524]", "GOBP_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_STEROL": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. [GOC:bf]", "GOBP_CELLULAR_RESPONSE_TO_STARVATION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. [GOC:jl]", "GOBP_CELLULAR_RESPONSE_TO_STEROL_DEPLETION": "", "GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_TESTOSTERONE_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_TEMPERATURE_STIMULUS": "", "GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. [GOC:bf]", "GOBP_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS": "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. [GOC:sjw, PMID:9916872]", "GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:pr]", "GOBP_CELLULAR_RESPONSE_TO_TYPE_II_INTERFERON": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_UV": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_UV_A": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_UV_B": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_STRESS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_UV_C": "", "GOBP_CELLULAR_RESPONSE_TO_VITAMIN": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_VITAMIN_D": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, PMID:18440775]", "GOBP_CELLULAR_RESPONSE_TO_VIRUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:dos]", "GOBP_CELLULAR_RESPONSE_TO_WATER_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_X_RAY": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_ZINC_ION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. [GOC:mah]", "GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:krc, GOC:mah]", "GOBP_CELLULAR_SENESCENCE": "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. [GOC:BHF, PMID:28682291]", "GOBP_CELL_ADHESION_INVOLVED_IN_HEART_MORPHOGENESIS": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart. [GOC:dph, GOC:mtg_heart, PMID:16860783]", "GOBP_CELL_ADHESION_MOLECULE_PRODUCTION": "The appearance of a cell adhesion molecule due to biosynthesis or secretion. [GOC:BHF, GOC:rl]", "GOBP_CELL_AGGREGATION": "The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. [GOC:dos]", "GOBP_CELL_ADHESION_MEDIATED_BY_INTEGRIN": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. [GOC:add, PMID:12213832, PMID:14754902]", "GOBP_CELL_CELL_ADHESION_INVOLVED_IN_GASTRULATION": "The attachment of one cell to another cell affecting gastrulation. [GOC:dsf, PMID:19091770]", "GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_CELL_CELL_ADHESION": "The attachment of one cell to another cell via adhesion molecules. [GOC:dos]", "GOBP_CELL_CELL_ADHESION_MEDIATED_BY_INTEGRIN": "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. [GOC:add, PMID:12213832, PMID:14754902]", "GOBP_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN": "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains. [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970]", "GOBP_CELL_ADHESION": "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]", "GOBP_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES": "", "GOBP_CELL_CELL_JUNCTION_DISASSEMBLY": "The disaggregation of a cell-cell junction into its constituent components. [GOC:aruk, PMID:25490267]", "GOBP_CELL_CELL_JUNCTION_MAINTENANCE": "The maintenance of junctions between cells. [GOC:ai]", "GOBP_CELL_CELL_JUNCTION_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a junction between cells. [GOC:ai]", "GOBP_CELL_CELL_RECOGNITION": "Cell recognition between cells. May involve the formation of specialized cell junctions. [ISBN:0824072820]", "GOBP_CELL_CELL_JUNCTION_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]", "GOBP_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION": "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING_INVOLVED_IN_CARDIAC_CONDUCTION": "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_CELL_ACTIVATION": "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell. [GOC:mgi_curators]", "GOBP_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING": "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]", "GOBP_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION": "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_CELL_CHEMOTAXIS": "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]", "GOBP_CELL_CELL_SIGNALING": "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]", "GOBP_CELL_CYCLE_DNA_REPLICATION_INITIATION": "Any DNA replication initiation that is involved in cell cycle DNA replication. [GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_CELL_CYCLE_CHECKPOINT_SIGNALING": "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. [GOC:mtg_cell_cycle]", "GOBP_CELL_CYCLE_DNA_REPLICATION": "The DNA-dependent DNA replication that takes place as part of the cell cycle. [GOC:mtg_cell_cycle]", "GOBP_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT": "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. [GOC:dph]", "GOBP_CELL_CYCLE_G2_M_PHASE_TRANSITION": "The cell cycle process by which a cell in G2 phase commits to M phase. [GOC:jl, GOC:mtg_cell_cycle]", "GOBP_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]", "GOBP_CELL_CYCLE": "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. [GOC:go_curators, GOC:mtg_cell_cycle]", "GOBP_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. [GOC:mah, GOC:mtg_kidney_jan10]", "GOBP_CELL_CYCLE_PHASE_TRANSITION": "The cell cycle process by which a cell commits to entering the next cell cycle phase. [GOC:mtg_cell_cycle]", "GOBP_CELL_DIFFERENTIATION_INVOLVED_IN_PHENOTYPIC_SWITCHING": "A cell differentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. [GOC:curators]", "GOBP_CELL_DIFFERENTIATION_IN_HINDBRAIN": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CELL_CYCLE_G1_S_PHASE_TRANSITION": "The cell cycle process by which a cell in G1 phase commits to S phase. [GOC:mtg_cell_cycle]", "GOBP_CELL_CYCLE_PROCESS": "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. [GOC:isa_complete, GOC:mtg_cell_cycle]", "GOBP_CELL_DIFFERENTIATION_IN_SPINAL_CORD": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]", "GOBP_CELL_FATE_COMMITMENT_INVOLVED_IN_PATTERN_SPECIFICATION": "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. [GOC:dph]", "GOBP_CELL_DIVISION": "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]", "GOBP_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION": "", "GOBP_CELL_FATE_DETERMINATION": "The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division. [ISBN:0878932437]", "GOBP_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER": "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_CELL_FATE_SPECIFICATION": "The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate. [GOC:go_curators]", "GOBP_CELL_FATE_COMMITMENT": "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. [ISBN:0716731185]", "GOBP_CELL_JUNCTION_DISASSEMBLY": "The disaggregation of a cell junction into its constituent components. [GOC:aruk, PMID:25490267]", "GOBP_CELL_GROWTH": "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. [GOC:ai]", "GOBP_CELL_JUNCTION_MAINTENANCE": "The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_CELL_JUNCTION_ASSEMBLY": "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. [GOC:mah]", "GOBP_CELL_MIGRATION_INVOLVED_IN_GASTRULATION": "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). [GOC:jl, PMID:16099638]", "GOBP_CELL_MATRIX_ADHESION": "The binding of a cell to the extracellular matrix via adhesion molecules. [GOC:hb]", "GOBP_CELL_MIGRATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]", "GOBP_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT": "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. [GOC:mtg_heart]", "GOBP_CELL_MATURATION": "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. [GOC:go_curators]", "GOBP_CELL_MIGRATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT": "", "GOBP_CELL_KILLING": "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. [GOC:add]", "GOBP_CELL_JUNCTION_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_CELL_MIGRATION_IN_HINDBRAIN": "The orderly movement of a cell that will reside in the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS": "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. [PMID:16391003]", "GOBP_CELL_MOTILITY_INVOLVED_IN_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION": "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS": "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. [GOC:dph, GOC:mtg_heart]", "GOBP_CELL_MORPHOGENESIS": "The developmental process in which the size or shape of a cell is generated and organized. [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_CELL_PROLIFERATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT": "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION": "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. [GOC:dph, GOC:tb]", "GOBP_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney. [GOC:mtg_kidney_jan10]", "GOBP_CELL_PROJECTION_ASSEMBLY": "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, PMID:18391171]", "GOBP_CELL_MOTILITY": "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]", "GOBP_CELL_PROLIFERATION_IN_BONE_MARROW": "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow. [GOC:mah, GOC:yaf, PMID:17063141]", "GOBP_CELL_PROLIFERATION_IN_HINDBRAIN": "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CELL_PROJECTION_MORPHOGENESIS": "The process in which the anatomical structures of a cell projection are generated and organized. [GO_REF:0000021]", "GOBP_CELL_PROLIFERATION_IN_FOREBRAIN": "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CELL_PROJECTION_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, PMID:16318917]", "GOBP_CELL_PROLIFERATION_IN_MIDBRAIN": "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. [GO_REF:0000021, GOC:dgf]", "GOBP_CELL_REDOX_HOMEOSTASIS": "Any process that maintains the redox environment of a cell or compartment within a cell. [GOC:ai, GOC:dph, GOC:tb, PMID:38689066]", "GOBP_CELL_RECOGNITION": "The process in which a cell in an organism interprets its surroundings. [GOC:go_curators]", "GOBP_CELL_SUBSTRATE_JUNCTION_DISASSEMBLY": "The disaggregation of a cell-substrate junction into its constituent components. [GOC:aruk, GOC:bc, PMID:25490267]", "GOBP_CELL_SUBSTRATE_JUNCTION_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix. [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]", "GOBP_CELL_SUBSTRATE_ADHESION": "The attachment of a cell to the underlying substrate via adhesion molecules. [GOC:mah, GOC:pf]", "GOBP_CELL_SURFACE_RECEPTOR_PROTEIN_TYROSINE_PHOSPHATASE_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]", "GOBP_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT": "", "GOBP_CELL_SURFACE_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]", "GOBP_CELL_SURFACE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]", "GOBP_CELL_VOLUME_HOMEOSTASIS": "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_CELL_SURFACE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]", "GOBP_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT": "An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. [GOC:rjd, PMID:21534947, PMID:24587195]", "GOBP_CEMENTUM_MINERALIZATION": "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum. [GOC:sl, PMID:17043865]", "GOBP_CENP_A_CONTAINING_CHROMATIN_ASSEMBLY": "The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]", "GOBP_CENTRAL_NERVOUS_SYSTEM_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]", "GOBP_CENTRAL_NERVOUS_SYSTEM_MYELIN_MAINTENANCE": "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state. [GOC:dgh]", "GOBP_CENTRAL_NERVOUS_SYSTEM_MYELIN_FORMATION": "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system. [GOC:dgh]", "GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT": "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS": "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS": "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CENTRIOLE_CENTRIOLE_COHESION": "The cell cycle process in which the two centrioles within a centrosome remain tightly paired. [GOC:dph, GOC:tb]", "GOBP_CENTRIOLE_ASSEMBLY": "A cellular process that results in the assembly of one or more centrioles. [GOC:dos, PMID:24075808]", "GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GOC:bf, GOC:jid, ISBN:0582227089]", "GOBP_CENTRIOLE_ELONGATION": "The centrosome organization process by which a centriole increases in length as part of the process of replication. [GOC:dph, PMID:21576394]", "GOBP_CENTROMERE_COMPLEX_ASSEMBLY": "", "GOBP_CENTROMERIC_SISTER_CHROMATID_COHESION": "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome. [GOC:mah]", "GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CENTROSOME_SEPARATION": "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. [GOC:ai]", "GOBP_CERAMIDE_1_PHOSPHATE_TRANSPORT": "The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:TermGenie, PMID:23863933]", "GOBP_CERAMIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. [GOC:ai]", "GOBP_CENTROSOME_DUPLICATION": "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. [GOC:ai]", "GOBP_CERAMIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. [GOC:ai]", "GOBP_CERAMIDE_TRANSPORT": "The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid. [GOC:bf, GOC:sart]", "GOBP_CEREBELLAR_CORTEX_FORMATION": "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CEREBELLAR_CORTEX_MORPHOGENESIS": "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CERAMIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. [ISBN:0198547684]", "GOBP_CEREBELLAR_CORTEX_DEVELOPMENT": "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT": "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CEREBELLAR_GRANULAR_LAYER_MORPHOGENESIS": "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CEREBELLAR_GRANULAR_LAYER_FORMATION": "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT": "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION": "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS": "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CEREBRAL_CORTEX_CELL_MIGRATION": "The orderly movement of cells from one site to another in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DEVELOPMENT": "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_MIGRATION": "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_CEREBRAL_CORTEX_DEVELOPMENT": "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION": "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_CEREBRAL_CORTEX_TANGENTIAL_MIGRATION": "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_CEREBRAL_CORTEX_REGIONALIZATION": "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CEREBROSPINAL_FLUID_CIRCULATION": "The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional. [GOC:mgi_curators, PMID:22100360, PMID:24229449]", "GOBP_CGAS_STING_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING. [PMID:27648547, PMID:34261127, PMID:34261128]", "GOBP_CGMP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. [ISBN:0198506732]", "GOBP_CGMP_CATABOLIC_PROCESS": "", "GOBP_CGMP_MEDIATED_SIGNALING": "", "GOBP_CGMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. [GOC:go_curators]", "GOBP_CHAPERONE_MEDIATED_AUTOPHAGY": "The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded. [GOC:pad, GOC:PARL, PMID:22743996, PMID:23434281]", "GOBP_CHAPERONE_COFACTOR_DEPENDENT_PROTEIN_REFOLDING": "", "GOBP_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. [GOC:ai]", "GOBP_CHAPERONE_MEDIATED_PROTEIN_FOLDING": "", "GOBP_CHEMOKINE_C_C_MOTIF_LIGAND_5_PRODUCTION": "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]", "GOBP_CHEMOKINE_C_X_C_MOTIF_LIGAND_12_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, Wikipedia:Stromal_cell-derived_factor-1]", "GOBP_CHEMOKINE_C_X_C_MOTIF_LIGAND_1_PRODUCTION": "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah]", "GOBP_CHEMOKINE_C_X_C_MOTIF_LIGAND_2_PRODUCTION": "The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:mah]", "GOBP_CHEMICAL_SYNAPTIC_TRANSMISSION_POSTSYNAPTIC": "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol. [GOC:dos]", "GOBP_CHEMOREPULSION_OF_AXON": "The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. [GOC:dph, GOC:krc]", "GOBP_CHEMOKINE_PRODUCTION": "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, ISBN:0198506732, PMID:12183377, Wikipedia:Chemokine]", "GOBP_CHEMOSENSORY_BEHAVIOR": "Behavior that is dependent upon the sensation of chemicals. [GOC:go_curators]", "GOBP_CHIASMA_ASSEMBLY": "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids. [PMID:23396135]", "GOBP_CHITIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]", "GOBP_CHOLESTEROL_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai]", "GOBP_CHLORIDE_TRANSPORT": "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_CHOLANGIOCYTE_PROLIFERATION": "", "GOBP_CHOLESTEROL_IMPORT": "The directed movement of cholesterol into a cell or organelle. [GOC:BHF, GOC:rl]", "GOBP_CHEMICAL_HOMEOSTASIS": "Any biological process involved in the maintenance of an internal steady state of a chemical. [GOC:isa_complete]", "GOBP_CHOLESTEROL_EFFLUX": "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:sart]", "GOBP_CHOLESTEROL_STORAGE": "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_CHOLINE_TRANSPORT": "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:ai]", "GOBP_CHOLINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:jl, ISBN:0192801023]", "GOBP_CHONDROBLAST_DIFFERENTIATION": "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. [GOC:dph]", "GOBP_CHONDROCYTE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS": "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_CHONDROCYTE_DEVELOPMENT": "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. [GOC:dph]", "GOBP_CHONDROCYTE_DIFFERENTIATION_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS": "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_CHONDROCYTE_HYPERTROPHY": "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_CHONDROCYTE_PROLIFERATION": "The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. [CL:0000138, GOC:yaf, PMID:21484705]", "GOBP_CHONDROCYTE_DIFFERENTIATION": "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. [GOC:dph]", "GOBP_CHONDROITIN_SULFATE_METABOLIC_PROCESS": "", "GOBP_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycans, which consist of a core protein linked to a chondroitin sulfate glycosaminoglycan. The chondroitin sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-glucuronic acid-beta-(1,3)-N-acetyl-D-galactosamine, the latter of which can be O-sulfated. Chondroitin sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate). [PMID:17239763]", "GOBP_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS": "", "GOBP_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS": "The chemical reactions and pathways involving chondroitin sulfate proteoglycans, which consist of a core protein linked to a chondroitin sulfate glycosaminoglycan. The chondroitin sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-glucuronic acid-beta-(1,3)-N-acetyl-D-galactosamine, the latter of which can be O-sulfated. [PMID:17239763]", "GOBP_CHORIONIC_TROPHOBLAST_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer. [CL:0011101, GOC:dph, PMID:16983341]", "GOBP_CHORION_DEVELOPMENT": "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane. [GOC:dph]", "GOBP_CHORIONIC_TROPHOBLAST_CELL_PROLIFERATION": "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population. [CL:0011101, GOC:BHF, PMID:15150278]", "GOBP_CHORIO_ALLANTOIC_FUSION": "The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois. [GOC:dph]", "GOBP_CHROMATIN_LOOPING": "A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome. [PMID:32213323]", "GOBP_CHROMOSOME_ATTACHMENT_TO_THE_NUCLEAR_ENVELOPE": "The process in which chromatin is anchored to the nuclear envelope. [GOC:vw, PMID:31635174]", "GOBP_CHROMOSOME_MOVEMENT_TOWARDS_SPINDLE_POLE": "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes. [GOC:ai]", "GOBP_CHROMOSOME_CONDENSATION": "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. [GOC:mah, ISBN:0815316194]", "GOBP_CHROMOSOME_LOCALIZATION": "Any process in which a chromosome is transported to, or maintained in, a specific location. [GOC:ai]", "GOBP_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE": "A process of chromosome organization that is involved in a meiotic cell cycle. [GOC:mah]", "GOBP_CHROMATIN_REMODELING": "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]", "GOBP_CHROMOSOME_SEPARATION": "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243]", "GOBP_CHRONIC_INFLAMMATORY_RESPONSE": "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. [GO_REF:0000022, GOC:jal, ISBN:0781735149]", "GOBP_CILIARY_BASAL_BODY_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum). [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124]", "GOBP_CHROMOSOME_ORGANIZATION": "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]", "GOBP_CHROMOSOME_SEGREGATION": "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]", "GOBP_CILIARY_NEUROTROPHIC_FACTOR_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah]", "GOBP_CILIUM_DISASSEMBLY": "A cellular process that results in the breakdown of a cilium. [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441]", "GOBP_CILIUM_MOVEMENT": "The directed, self-propelled movement of a cilium. [GOC:dph, GOC:jl]", "GOBP_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION": "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah]", "GOBP_CIRCADIAN_SLEEP_WAKE_CYCLE": "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. [GOC:jl, PMID:26947521, PMID:33537937]", "GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY": "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. [GOC:cilia, GOC:hjd, GOC:krc]", "GOBP_CILIUM_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. [GOC:cilia, GOC:jl]", "GOBP_CIRCADIAN_SLEEP_WAKE_CYCLE_SLEEP": "The part of the circadian sleep/wake cycle where the organism is asleep. [GOC:ai]", "GOBP_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP": "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions. [GOC:jl, PMID:33537937]", "GOBP_CIRCADIAN_RHYTHM": "Any biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:bf, GOC:go_curators]", "GOBP_CITRATE_METABOLIC_PROCESS": "", "GOBP_CITRULLINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. [ISBN:0198506732]", "GOBP_CITRULLINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. [ISBN:0198506732]", "GOBP_CLATHRIN_COATED_VESICLE_CARGO_LOADING": "Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle. [GOC:lb, PMID:16162817]", "GOBP_CIRCULATORY_SYSTEM_PROCESS": "An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. [GOC:mtg_cardio]", "GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. [GOC:mah, UBERON:0001009]", "GOBP_CLATHRIN_COAT_ASSEMBLY": "The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]", "GOBP_CLEARANCE_OF_FOREIGN_INTRACELLULAR_NUCLEIC_ACIDS": "A defense process that protects an organism from DNA or RNA from an invading organism. [GO:dos]", "GOBP_CLATHRIN_DEPENDENT_ENDOCYTOSIS": "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]", "GOBP_CLEAVAGE_FURROW_FORMATION": "Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell. [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590]", "GOBP_CMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving CMP, cytidine monophosphate. [GOC:go_curators]", "GOBP_CLUSTERING_OF_VOLTAGE_GATED_SODIUM_CHANNELS": "The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization. [PMID:11456440]", "GOBP_COBALAMIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. [GOC:go_curators]", "GOBP_COBALT_ION_TRANSPORT": "The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_COBALAMIN_TRANSPORT": "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_COCHLEA_MORPHOGENESIS": "The process in which the cochlea is generated and organized. [GOC:dph, GOC:tb]", "GOBP_COCHLEA_DEVELOPMENT": "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. [GOC:dph, GOC:tb]", "GOBP_COENZYME_A_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [ISBN:0198547684]", "GOBP_COENZYME_A_METABOLIC_PROCESS": "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [ISBN:0198547684]", "GOBP_COLLAGEN_ACTIVATED_TYROSINE_KINASE_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, PMID:15888913, PMID:16626936]", "GOBP_COLLAGEN_ACTIVATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, PMID:21568710]", "GOBP_COLLAGEN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:mah, ISBN:0198506732]", "GOBP_COGNITION": "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. [ISBN:0721619908]", "GOBP_COLLAGEN_CATABOLIC_PROCESS": "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194]", "GOBP_COLLAGEN_FIBRIL_ORGANIZATION": "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. [GOC:mah, ISBN:0815316194]", "GOBP_COLLATERAL_SPROUTING": "The process in which outgrowths develop from the shafts of existing axons. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]", "GOBP_COLLATERAL_SPROUTING_IN_ABSENCE_OF_INJURY": "The process in which outgrowths develop from the axons of intact undamaged neurons. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]", "GOBP_COLLAGEN_METABOLIC_PROCESS": "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:mah, ISBN:0198506732]", "GOBP_COLLECTING_DUCT_DEVELOPMENT": "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. [GOC:mtg_kidney_jan10]", "GOBP_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. [GOC:dph]", "GOBP_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. [GOC:dph]", "GOBP_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_MATURATION": "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. [GOC:dph]", "GOBP_COMMISSURAL_NEURON_AXON_GUIDANCE": "The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:mah]", "GOBP_COMMA_SHAPED_BODY_MORPHOGENESIS": "The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron. [GOC:mtg_kidney_jan10]", "GOBP_COMMON_MYELOID_PROGENITOR_CELL_PROLIFERATION": "The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage. [CL:0000049, GOC:BHF]", "GOBP_COMPARTMENT_PATTERN_SPECIFICATION": "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]", "GOBP_COMMON_BILE_DUCT_DEVELOPMENT": "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. [PMID:20614624]", "GOBP_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY": "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. [GOC:add, ISBN:0781735149]", "GOBP_COMPLEMENT_ACTIVATION": "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_COMPLEMENT_DEPENDENT_CYTOTOXICITY": "Cell killing caused by the membrane attack complex formed following complement activation. [GOC:add, GOC:rv]", "GOBP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY": "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. [GOC:add, ISBN:0781735149]", "GOBP_COMPLEMENT_ACTIVATION_LECTIN_PATHWAY": "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. [GOC:add, ISBN:0781735149]", "GOBP_CONDITIONED_PLACE_PREFERENCE": "The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug. [PMID:21549821]", "GOBP_COMPLEMENT_RECEPTOR_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_CONNECTIVE_TISSUE_REPLACEMENT": "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:25590961]", "GOBP_CONNECTIVE_TISSUE_REPLACEMENT_INVOLVED_IN_INFLAMMATORY_RESPONSE_WOUND_HEALING": "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared, as part of an inflammatory response. [GOC:jal, PMID:9639571]", "GOBP_CONSTITUTIVE_HETEROCHROMATIN_FORMATION": "The compaction of chromatin into heterochromatin, a conformation that is refractory to transcription. Constitutive heterochromatin cannot be converted back to euchromatin, the transcriptionally-active conformation. In metazoa, this involves the methylation of histone H3K9. [PMID:17936700]", "GOBP_CONVERGENT_EXTENSION": "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. [GOC:dgf, GOC:dph, PMID:12062082]", "GOBP_CONSTITUTIVE_SECRETORY_PATHWAY": "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space. [GOC:mah, ISBN:0716731363]", "GOBP_CONVERGENT_EXTENSION_INVOLVED_IN_GASTRULATION": "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. [GOC:dph, PMID:12062082]", "GOBP_CONVERGENT_EXTENSION_INVOLVED_IN_AXIS_ELONGATION": "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism. [GOC:dph, PMID:12062082]", "GOBP_CONNECTIVE_TISSUE_DEVELOPMENT": "The progression of a connective tissue over time, from its formation to the mature structure. [GOC:BHF]", "GOBP_COP9_SIGNALOSOME_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome. [PMID:17307927]", "GOBP_CONVERGENT_EXTENSION_INVOLVED_IN_ORGANOGENESIS": "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ. [GOC:dph, PMID:12062082]", "GOBP_COPII_COATED_VESICLE_CARGO_LOADING": "The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi. [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]", "GOBP_COPII_COATED_VESICLE_BUDDING": "The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_COPI_COATED_VESICLE_BUDDING": "The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle. [GOC:br, PMID:10052452, PMID:17041781]", "GOBP_COPPER_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]", "GOBP_COPPER_ION_TRANSMEMBRANE_TRANSPORT": "The directed movement of copper cation across a membrane. [GOC:vw]", "GOBP_COPPER_ION_IMPORT": "The directed movement of copper ions into a cell or organelle. [GOC:ai]", "GOBP_COPPER_ION_TRANSPORT": "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_COPULATION": "The act of sexual union between male and female, involving the transfer of sperm. [ISBN:0721662544]", "GOBP_CORNEA_DEVELOPMENT_IN_CAMERA_TYPE_EYE": "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. [GOC:dph]", "GOBP_CORNIFICATION": "A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability). [GOC:krc, PMID:18846107]", "GOBP_CORNIFIED_ENVELOPE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a cornified envelope. [GO_REF:0000079, GOC:pm, GOC:TermGenie, PMID:22226963, PMID:24794495]", "GOBP_CORONARY_ARTERY_MORPHOGENESIS": "The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle. [GOC:mtg_heart]", "GOBP_CORONARY_VASCULATURE_DEVELOPMENT": "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_CORPUS_CALLOSUM_DEVELOPMENT": "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_CORPUS_CALLOSUM_MORPHOGENESIS": "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CORONARY_VASCULATURE_MORPHOGENESIS": "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. [GOC:mtg_heart]", "GOBP_CORTICAL_ACTIN_CYTOSKELETON_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. [GOC:dph, GOC:jl, GOC:mah, GOC:pf]", "GOBP_CORTICOSPINAL_TRACT_MORPHOGENESIS": "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731]", "GOBP_CORTICOSTEROID_HORMONE_SECRETION": "The regulated release of any corticosteroid hormone into the circulatory system. [GOC:sl]", "GOBP_CORTICAL_CYTOSKELETON_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_CORTICOTROPIN_SECRETION": "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus. [GOC:cjm, PMID:11027914]", "GOBP_CORTICOSTERONE_SECRETION": "The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. [GOC:sl]", "GOBP_CORTISOL_BIOSYNTHETIC_PROCESS": "", "GOBP_CORTISOL_SECRETION": "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. [PMID:11027914]", "GOBP_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE": "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. [ISBN:0716731363, PMID:10512867, PMID:16896215]", "GOBP_CORTISOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties. [GOC:BHF, GOC:mah, GOC:rl]", "GOBP_CRANIAL_GANGLION_DEVELOPMENT": "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. [GOC:dph]", "GOBP_CO_TRANSCRIPTIONAL_RNA_3_END_PROCESSING_CLEAVAGE_AND_POLYADENYLATION_PATHWAY": "Any process involved in transcription termination-coupled 3' processing of RNA polymerase II RNA transcripts by 3' end cleavage and addition of a poly(A) tail. [PMID:31499460]", "GOBP_CRANIAL_NERVE_STRUCTURAL_ORGANIZATION": "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CRANIAL_NERVE_MORPHOGENESIS": "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CRANIAL_NERVE_DEVELOPMENT": "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CRANIAL_NERVE_FORMATION": "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_CRD_MEDIATED_MRNA_STABILIZATION": "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). [GOC:mah, PMID:19029303]", "GOBP_CRANIAL_SUTURE_MORPHOGENESIS": "The process in which any suture between cranial bones is generated and organized. [GOC:dph, GOC:pr, GOC:sl]", "GOBP_CRANIOFACIAL_SUTURE_MORPHOGENESIS": "The process in which any suture between cranial and/or facial bones is generated and organized. [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]", "GOBP_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227]", "GOBP_CRISTAE_FORMATION": "The assembly of cristae, the inwards folds of the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732]", "GOBP_CUT_METABOLIC_PROCESS": "", "GOBP_CXCL12_ACTIVATED_CXCR4_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn]", "GOBP_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:go_curators, ISBN:0198506732]", "GOBP_CYCLIC_GMP_AMP_TRANSMEMBRANE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol. [PMID:31126740]", "GOBP_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:go_curators, ISBN:0198506732]", "GOBP_CYCLIC_NUCLEOTIDE_TRANSPORT": "The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell. [GOC:mah, ISBN:0198506732]", "GOBP_CYSTEINE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]", "GOBP_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:go_curators, ISBN:0198506732]", "GOBP_CYCLOOXYGENASE_PATHWAY": "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. [PMID:19854273]", "GOBP_CYSTEINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]", "GOBP_CYTIDINE_METABOLIC_PROCESS": "", "GOBP_CYTIDINE_TO_URIDINE_EDITING": "The conversion of a cytosine residue to uridine in an RNA molecule by deamination. [PMID:11092837]", "GOBP_CYTOCHROME_METABOLIC_PROCESS": "The chemical reactions and pathways involving a cytochrome. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088]", "GOBP_CYTOCHROME_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. [GOC:jl, GOC:mah]", "GOBP_CYTOKINETIC_PROCESS": "A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). [GOC:bf, GOC:isa_complete, GOC:mah]", "GOBP_CYTOKINESIS": "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. [GOC:mtg_cell_cycle]", "GOBP_CYTOLYSIS": "The rupture of cell membranes and the loss of cytoplasm. [UniProtKB-KW:KW-0204]", "GOBP_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE": "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_CYTOLYSIS_BY_HOST_OF_SYMBIONT_CELLS": "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:add]", "GOBP_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE": "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]", "GOBP_CYTOKINE_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629]", "GOBP_CYTOPLASMIC_MICROTUBULE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. [GOC:mah]", "GOBP_CYTOKINE_PRODUCTION": "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]", "GOBP_CYTOPLASMIC_SEQUESTERING_OF_NF_KAPPAB": "", "GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438]", "GOBP_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN": "", "GOBP_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR": "", "GOBP_CYTOPLASMIC_TRANSLATIONAL_ELONGATION": "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm. [GOC:hjd]", "GOBP_CYTOPLASM_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [GOC:curators, GOC:dph, GOC:jl, GOC:mah]", "GOBP_CYTOPLASMIC_TRANSLATIONAL_INITIATION": "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [GOC:hjd]", "GOBP_CYTOPLASMIC_TRANSLATION": "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]", "GOBP_CYTOSKELETON_DEPENDENT_CYTOKINESIS": "A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. [GOC:dph]", "GOBP_CYTOSOLIC_RIBOSOME_ASSEMBLY": "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol. [GOC:ma, PMID:30467428]", "GOBP_CYTOSOL_TO_ENDOPLASMIC_RETICULUM_TRANSPORT": "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell. [GOC:ai]", "GOBP_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION": "The alteration of the C-terminal amino acid residue in a protein. [GOC:mah]", "GOBP_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT": "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. [GOC:mah]", "GOBP_CYTOSOLIC_TRANSPORT": "The directed movement of substances or organelles within the cytosol. [GOC:ai]", "GOBP_C_TERMINAL_PROTEIN_LIPIDATION": "", "GOBP_C_X_C_CHEMOKINE_RECEPTOR_CXCR4_SIGNALING_PATHWAY": "The series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]", "GOBP_DAMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). [GOC:go_curators]", "GOBP_DCMP_CATABOLIC_PROCESS": "", "GOBP_DEADENYLATION_DEPENDENT_DECAPPING_OF_NUCLEAR_TRANSCRIBED_MRNA": "", "GOBP_DECIDUALIZATION": "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. [ISBN:0721662544, PMID:11133685]", "GOBP_CYTOSKELETON_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_DEDIFFERENTIATION": "The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors. [GOC:dph, GOC:pg]", "GOBP_DEFENSE_RESPONSE_TO_FUNGUS": "", "GOBP_DEFENSE_RESPONSE_TO_TUMOR_CELL": "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism. [GOC:add, ISBN:0781735149, PMID:16730260]", "GOBP_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM": "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. [GOC:ai]", "GOBP_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM": "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai]", "GOBP_DEFENSE_RESPONSE_TO_BACTERIUM": "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]", "GOBP_DEHYDROASCORBIC_ACID_TRANSPORT": "The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C. [GOC:sl]", "GOBP_DEFINITIVE_HEMOPOIESIS": "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continuously provide erythroid, myeloid and lymphoid lineages throughout adulthood. [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]", "GOBP_DEFENSE_RESPONSE": "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. [GOC:go_curators]", "GOBP_DELAMINATION": "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet. [GOC:dph, PMID:16962574, PMID:18343170]", "GOBP_DEFENSE_RESPONSE_TO_VIRUS": "Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]", "GOBP_DEMETHYLATION": "The process of removing one or more methyl groups from a molecule. [GOC:BHF, GOC:rl]", "GOBP_DENDRITE_ARBORIZATION": "The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches. [GOC:aruk, GOC:bc, PMID:23270857]", "GOBP_DENDRITE_EXTENSION": "Long distance growth of a single dendrite involved in cellular development. [GOC:BHF, GOC:rl]", "GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM": "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. [GOC:dos]", "GOBP_DENDRITE_DEVELOPMENT": "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]", "GOBP_DENDRITE_SELF_AVOIDANCE": "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell. [GOC:sart, PMID:17482551]", "GOBP_DENDRITE_MORPHOGENESIS": "The process in which the anatomical structures of a dendrite are generated and organized. [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]", "GOBP_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION": "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]", "GOBP_DENDRITIC_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845]", "GOBP_DENDRITIC_CELL_CHEMOTAXIS": "The movement of a dendritic cell in response to an external stimulus. [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]", "GOBP_DENDRITIC_CELL_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a dendritic cell. [GOC:add, ISBN:0781735149]", "GOBP_DENDRITIC_CELL_MIGRATION": "The movement of a dendritic cell within or between different tissues and organs of the body. [CL:0000451, GOC:nhn, PMID:19339990]", "GOBP_DENDRITIC_SPINE_MAINTENANCE": "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. [GOC:BHF, PMID:20410104]", "GOBP_DENDRITIC_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. [CL:0000451, GOC:pr]", "GOBP_DENDRITIC_SPINE_DEVELOPMENT": "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]", "GOBP_DENDRITIC_TRANSPORT": "The directed movement of organelles or molecules along microtubules in dendrites. [ISBN:0815316194]", "GOBP_DENDRITIC_TRANSPORT_OF_RIBONUCLEOPROTEIN_COMPLEX": "", "GOBP_DENDRITIC_SPINE_MORPHOGENESIS": "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]", "GOBP_DENSE_CORE_GRANULE_EXOCYTOSIS": "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels. [GOC:kmv, PMID:17553987, PMID:24653208]", "GOBP_DENSE_CORE_GRANULE_TRANSPORT": "The directed movement a dense core granule within a cell. [GOC:kmv, GOC:TermGenie, PMID:23358451]", "GOBP_DENTATE_GYRUS_DEVELOPMENT": "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_DENTINOGENESIS": "The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin. [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]", "GOBP_DEOXYRIBONUCLEOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:jl, ISBN:0140512713]", "GOBP_DEOXYRIBONUCLEOSIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]", "GOBP_DEOXYRIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS": "", "GOBP_DEOXYRIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_DEOXYRIBONUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS": "", "GOBP_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_DEOXYRIBONUCLEOSIDE_MONOPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_DEOXYRIBONUCLEOTIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_DEPYRIMIDINATION": "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar. [GOC:ai]", "GOBP_DERMATAN_SULFATE_BIOSYNTHETIC_PROCESS": "", "GOBP_DERMATAN_SULFATE_METABOLIC_PROCESS": "", "GOBP_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_DERMATAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycans, which consist of a core protein linked to a dermatan sulfate glycosaminoglycan. The dermatan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-hexuronic acid-beta-(1,3)-N-acetyl-D-galactosamine. Tthe former can be a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter can be O-sulfated. Dermatan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate). [PMID:17239763]", "GOBP_DEPHOSPHORYLATION": "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732]", "GOBP_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS": "The chemical reactions and pathways involving dermatan sulfate proteoglycans, which consist of a core protein linked to a dermatan sulfate glycosaminoglycan. The dermatan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-hexuronic acid-beta-(1,3)-N-acetyl-D-galactosamine. The former can be a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter can be O-sulfated. [PMID:17239763]", "GOBP_DESMOSOME_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. [GOC:hjd]", "GOBP_DETECTION_OF_BACTERIUM": "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal. [GOC:hb]", "GOBP_DETECTION_OF_ABIOTIC_STIMULUS": "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. [GOC:hb]", "GOBP_DETECTION_OF_CALCIUM_ION": "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. [GOC:pg]", "GOBP_DETECTION_OF_BIOTIC_STIMULUS": "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. [GOC:hb]", "GOBP_DETECTION_OF_CELL_DENSITY": "The series of events in which information about the density of cells in a population is received and converted into a molecular signal. [GOC:dph]", "GOBP_DETECTION_OF_EXTERNAL_BIOTIC_STIMULUS": "The series of events in which an external biotic stimulus is detected and converted into a molecular signal. An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated. [GOC:dos]", "GOBP_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE": "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. [GOC:ai]", "GOBP_DETECTION_OF_LIGHT_STIMULUS": "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. [GOC:go_curators]", "GOBP_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION": "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. [GOC:ai, GOC:dos]", "GOBP_DETECTION_OF_LIPOPOLYSACCHARIDE": "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, PMID:15998797]", "GOBP_DETECTION_OF_MECHANICAL_STIMULUS": "The series of events by which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]", "GOBP_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN": "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]", "GOBP_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION": "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. [GOC:ai, GOC:dos]", "GOBP_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN": "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. [GOC:add, GOC:rl]", "GOBP_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND": "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. [GOC:ai]", "GOBP_DETECTION_OF_MUSCLE_STRETCH": "The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal. [PMID:14583192]", "GOBP_DETECTION_OF_OTHER_ORGANISM": "The series of events in which a stimulus from another organism is received and converted into a molecular signal. [GOC:dos]", "GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN": "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. [PMID:19837031]", "GOBP_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN": "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]", "GOBP_DETECTION_OF_TEMPERATURE_STIMULUS": "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. [GOC:hb]", "GOBP_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_THERMOCEPTION": "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception. [GOC:ai, GOC:dos]", "GOBP_DETECTION_OF_VIRUS": "", "GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION": "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos, GOC:dph]", "GOBP_DETERMINATION_OF_DIGESTIVE_TRACT_LEFT_RIGHT_ASYMMETRY": "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:cvs]", "GOBP_DETECTION_OF_VISIBLE_LIGHT": "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. [GOC:go_curators, ISBN:0198506732]", "GOBP_DETERMINATION_OF_ADULT_LIFESPAN": "The pathways that regulate the duration of the adult phase of the life-cycle of an animal. [PMID:25561524, PMID:273723695, PMID:3424805]", "GOBP_DETECTION_OF_STIMULUS": "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. [GOC:add, GOC:ai, GOC:dph, GOC:mah]", "GOBP_DETERMINATION_OF_LEFT_RIGHT_ASYMMETRY_IN_LATERAL_MESODERM": "The establishment of the lateral mesoderm with respect to the left and right halves. [GOC:mtg_heart]", "GOBP_DETERMINATION_OF_DORSAL_VENTRAL_ASYMMETRY": "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis. [GOC:jid]", "GOBP_DETERMINATION_OF_LIVER_LEFT_RIGHT_ASYMMETRY": "Determination of the asymmetric location of the liver with respect to the left and right halves of the organism. [GOC:cvs]", "GOBP_DETERMINATION_OF_PANCREATIC_LEFT_RIGHT_ASYMMETRY": "Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism. [GOC:dgh, PMID:12702646]", "GOBP_DETOXIFICATION_OF_INORGANIC_COMPOUND": "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds. [GOC:vw]", "GOBP_DETOXIFICATION_OF_COPPER_ION": "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion. [GOC:kmv, PMID:16367966]", "GOBP_DETOXIFICATION_OF_NITROGEN_COMPOUND": "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. [GOC:ai]", "GOBP_DETOXIFICATION": "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:dos]", "GOBP_DEVELOPMENTAL_CELL_GROWTH": "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. [GOC:go_curators, GOC:isa_complete]", "GOBP_DEVELOPMENTAL_INDUCTION": "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535]", "GOBP_DEVELOPMENTAL_PIGMENTATION": "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. [ISBN:0582227089]", "GOBP_DEVELOPMENT_OF_SECONDARY_FEMALE_SEXUAL_CHARACTERISTICS": "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion. [GOC:ai]", "GOBP_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS": "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. [GOC:dph]", "GOBP_DEVELOPMENT_OF_PRIMARY_FEMALE_SEXUAL_CHARACTERISTICS": "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. [GOC:ai]", "GOBP_DEVELOPMENTAL_GROWTH": "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. [GOC:go_curators]", "GOBP_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS": "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. [GOC:ai]", "GOBP_DEVELOPMENTAL_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_DE_NOVO_AMP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). [GOC:ecd, PMID:10888601]", "GOBP_DEVELOPMENT_OF_SECONDARY_SEXUAL_CHARACTERISTICS": "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion. [GOC:ai]", "GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION": "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. [GOC:dph, GOC:isa_complete]", "GOBP_DE_NOVO_CENTRIOLE_ASSEMBLY": "Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects. [GOC:cilia, PMID:25047614, PMID:25291643]", "GOBP_DE_NOVO_CENTRIOLE_ASSEMBLY_INVOLVED_IN_MULTI_CILIATED_EPITHELIAL_CELL_DIFFERENTIATION": "Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation. [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997]", "GOBP_DE_NOVO_NAD_BIOSYNTHETIC_PROCESS": "", "GOBP_DE_NOVO_PROTEIN_FOLDING": "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. [GOC:mb]", "GOBP_DE_NOVO_PYRIMIDINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. [GOC:mah, ISBN:0716720094]", "GOBP_DIACYLGLYCEROL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [GOC:curators]", "GOBP_DGMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). [GOC:go_curators]", "GOBP_DIACYLGLYCEROL_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [PMID:11717312]", "GOBP_DIACYLGLYCEROL_METABOLIC_PROCESS": "The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [PMID:11481335]", "GOBP_DIADENOSINE_POLYPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. [GOC:ai]", "GOBP_DIADENOSINE_POLYPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. [GOC:ai]", "GOBP_DIAPEDESIS": "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]", "GOBP_DIAPHRAGM_DEVELOPMENT": "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. [GOC:dph]", "GOBP_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. [ISBN:0198506732]", "GOBP_DICARBOXYLIC_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. [ISBN:0198506732]", "GOBP_DICHOTOMOUS_SUBDIVISION_OF_AN_EPITHELIAL_TERMINAL_UNIT": "The process in which an epithelial cord, rod or tube bifurcates at its end. [GOC:dph]", "GOBP_DICARBOXYLIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). [ISBN:0198506732]", "GOBP_DICARBOXYLIC_ACID_TRANSPORT": "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_DIET_INDUCED_THERMOGENESIS": "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signaling in the sympathetic nervous system. [PMID:12161655]", "GOBP_DIENCEPHALON_DEVELOPMENT": "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_DIGESTION": "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732]", "GOBP_DIOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. [GOC:curators]", "GOBP_DIOL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms. [GOC:mah]", "GOBP_DIGESTIVE_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:jid]", "GOBP_DIGESTIVE_TRACT_MORPHOGENESIS": "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:dph, GOC:go_curators, PMID:12618131]", "GOBP_DIGESTIVE_SYSTEM_PROCESS": "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]", "GOBP_DIPHOSPHOINOSITOL_POLYPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached. [GOC:mah, PMID:12387729]", "GOBP_DIPEPTIDE_TRANSMEMBRANE_TRANSPORT": "The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. [GOC:vw]", "GOBP_DISACCHARIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units. [GOC:jl, ISBN:0192800981]", "GOBP_DIRECT_OSSIFICATION": "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. [GO_REF:0000034]", "GOBP_DISRUPTION_OF_ANATOMICAL_STRUCTURE_IN_ANOTHER_ORGANISM": "The disruption of an anatomical structure of another organism, leading to damage or temporary subversion of that structure. [GOC:pg]", "GOBP_DISRUPTION_OF_CELLULAR_ANATOMICAL_STRUCTURE_IN_ANOTHER_ORGANISM": "The disruption of a cellular component of another organism, leading to damage or temporary subversion of that structure. In some cases this can cause malfunctioning of the cells and death of the target organism. [GOC:pg]", "GOBP_DITERPENOID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units. [GOC:mah, ISBN:0198547684]", "GOBP_DISTAL_CONVOLUTED_TUBULE_DEVELOPMENT": "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. [GOC:mtg_kidney_jan10]", "GOBP_DISTAL_TUBULE_DEVELOPMENT": "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. [GOC:mtg_kidney_jan10]", "GOBP_DNA_ALKYLATION_REPAIR": "The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases. [PMID:10946226, PMID:35543797]", "GOBP_DITERPENOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units. [ISBN:0198547684]", "GOBP_DNA_CONFORMATION_CHANGE": "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. [GOC:mah]", "GOBP_DNA_CATABOLIC_PROCESS": "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. [GOC:go_curators, ISBN:0198506732]", "GOBP_DNA_BIOSYNTHETIC_PROCESS": "The biosynthetic process resulting in the formation of DNA. [GOC:mah]", "GOBP_DNA_CYTOSINE_DEAMINATION": "The removal of an amino group from a cytosine residue in DNA, forming a uracil residue. [GOC:mah]", "GOBP_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR_RESULTING_IN_CELL_CYCLE_ARREST": "", "GOBP_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR": "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:go_curators]", "GOBP_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION": "", "GOBP_DNA_DEMETHYLATION": "", "GOBP_DNA_DOUBLE_STRAND_BREAK_PROCESSING": "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. [PMID:10357855]", "GOBP_DNA_DEAMINATION": "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil. [GOC:ai]", "GOBP_DNA_DAMAGE_RESPONSE": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]", "GOBP_DNA_INTEGRATION": "The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. [GOC:mah]", "GOBP_DNA_LIGATION": "", "GOBP_DNA_INTEGRITY_CHECKPOINT_SIGNALING": "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. [GOC:mtg_cell_cycle]", "GOBP_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR": "", "GOBP_DNA_METHYLATION_DEPENDENT_HETEROCHROMATIN_FORMATION": "", "GOBP_DNA_MODIFICATION": "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. [GOC:jl, GOC:ma]", "GOBP_DNA_PROTECTION": "Any process in which DNA is protected from damage by, for example, oxidative stress. [GOC:jl]", "GOBP_DNA_METABOLIC_PROCESS": "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. [ISBN:0198506732]", "GOBP_DNA_REPLICATION_DEPENDENT_CHROMATIN_ASSEMBLY": "The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation. [GOC:mah, PMID:28053344]", "GOBP_DNA_REPLICATION_CHECKPOINT_SIGNALING": "A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518]", "GOBP_DNA_REPAIR_DEPENDENT_CHROMATIN_REMODELING": "A chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions. [PMID:15528408, PMID:28053344, PMID:29095668, PMID:35689883]", "GOBP_DNA_REPLICATION_SYNTHESIS_OF_PRIMER": "The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer. [PMID:11395402, PMID:38203225, PMID:38492718]", "GOBP_DNA_RECOMBINATION": "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. [ISBN:0198506732]", "GOBP_DNA_REPLICATION_INITIATION": "The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. [PMID:28209641]", "GOBP_DNA_STRAND_ELONGATION": "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. [GOC:isa_complete, GOC:mah]", "GOBP_DNA_REPLICATION": "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. [GOC:mah]", "GOBP_DNA_REPAIR": "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]", "GOBP_DNA_STRAND_INVASION": "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. [GOC:elh, PMID:10357855]", "GOBP_DNA_STRAND_RESECTION_INVOLVED_IN_REPLICATION_FORK_PROCESSING": "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing. [GOC:mah, PMID:28475874]", "GOBP_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION": "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. [GOC:mah, ISBN:071673706X, ISBN:0815316194]", "GOBP_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR": "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. [PMID:10357855]", "GOBP_DNA_TEMPLATED_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY": "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. [GOC:mah, GOC:vw]", "GOBP_DNA_TEMPLATED_DNA_REPLICATION": "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. [GOC:mah, ISBN:0198506732]", "GOBP_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION": "The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template. [GOC:txnOH, PMID:15020047, PMID:18280161, PMID:30978344]", "GOBP_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION": "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]", "GOBP_DNA_TOPOLOGICAL_CHANGE": "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. [ISBN:071673706X, ISBN:0935702490]", "GOBP_DNA_UNWINDING_INVOLVED_IN_DNA_REPLICATION": "", "GOBP_DOLICHYL_DIPHOSPHATE_METABOLIC_PROCESS": "", "GOBP_DNA_TEMPLATED_TRANSCRIPTION_INITIATION": "The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. [GOC:jid, GOC:txnOH, PMID:18280161]", "GOBP_DOPAMINERGIC_NEURON_AXON_GUIDANCE": "The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues. [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]", "GOBP_DOPAMINERGIC_NEURON_DIFFERENTIATION": "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. [GOC:rph]", "GOBP_DOPAMINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732]", "GOBP_DOPAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732]", "GOBP_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_DOPAMINE_SECRETION": "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone. [GOC:ef]", "GOBP_DORSAL_ROOT_GANGLION_DEVELOPMENT": "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure. [PMID:18583150]", "GOBP_DORSAL_AORTA_DEVELOPMENT": "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]", "GOBP_DOPAMINE_TRANSPORT": "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:ai]", "GOBP_DORSAL_SPINAL_CORD_DEVELOPMENT": "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11179871]", "GOBP_DORSAL_AORTA_MORPHOGENESIS": "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]", "GOBP_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING": "The process in which the neural tube is regionalized in the dorsoventral axis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]", "GOBP_DORSAL_VENTRAL_AXIS_SPECIFICATION": "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_DORSAL_VENTRAL_PATTERN_FORMATION": "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]", "GOBP_DOUBLE_STRAND_BREAK_REPAIR_VIA_ALTERNATIVE_NONHOMOLOGOUS_END_JOINING": "An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment. [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining]", "GOBP_DOUBLE_STRAND_BREAK_REPAIR": "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh]", "GOBP_DOUBLE_STRAND_BREAK_REPAIR_INVOLVED_IN_MEIOTIC_RECOMBINATION": "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. [GOC:mah, PMID:15238514]", "GOBP_DOUBLE_STRAND_BREAK_REPAIR_VIA_BREAK_INDUCED_REPLICATION": "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. [GOC:elh, PMID:10357855]", "GOBP_DOUBLE_STRAND_BREAK_REPAIR_VIA_CLASSICAL_NONHOMOLOGOUS_END_JOINING": "An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining). [GOC:rph, PMID:18584027]", "GOBP_DOUBLE_STRAND_BREAK_REPAIR_VIA_SYNTHESIS_DEPENDENT_STRAND_ANNEALING": "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. [PMID:10357855]", "GOBP_DRINKING_BEHAVIOR": "The specific behavior of an organism relating to the intake of liquids, especially water. [GOC:curators, GOC:pr]", "GOBP_DOUBLE_STRAND_BREAK_REPAIR_VIA_SINGLE_STRAND_ANNEALING": "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats. [PMID:11606529]", "GOBP_DOUBLE_STRAND_BREAK_REPAIR_VIA_NONHOMOLOGOUS_END_JOINING": "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. [GOC:rph, PMID:10827453, PMID:24837021]", "GOBP_DTMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). [GOC:go_curators]", "GOBP_DTTP_METABOLIC_PROCESS": "", "GOBP_DUMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate). [GOC:go_curators]", "GOBP_DUCTUS_ARTERIOSUS_CLOSURE": "The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs. [GOC:hw]", "GOBP_D_ASPARTATE_TRANSMEMBRANE_TRANSPORT": "The process in which D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid  is transported across a lipid bilayer, from one side of a membrane to the other, by means of some agent such as a transporter or pore. [GOC:mah, GOC:rph]", "GOBP_D_AMINO_ACID_TRANSPORT": "The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, GOC:jsg, GOC:mah]", "GOBP_EARLY_ENDOSOME_TO_RECYCLING_ENDOSOME_TRANSPORT": "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes. [GOC:dph, GOC:kmv, PMID:21474295]", "GOBP_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT": "The directed movement of substances from early endosomes to the Golgi. [GOC:rb]", "GOBP_ECTODERMAL_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph, GOC:tb]", "GOBP_EATING_BEHAVIOR": "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. [GOC:jl, GOC:pr, PMID:19361967]", "GOBP_EAR_MORPHOGENESIS": "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. [GOC:jl, ISBN:0192801023]", "GOBP_ECTODERM_DEVELOPMENT": "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. [GOC:dph, GOC:tb]", "GOBP_EAR_DEVELOPMENT": "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. [GOC:jl, ISBN:0192801023]", "GOBP_ECTODERMAL_PLACODE_DEVELOPMENT": "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. [GOC:mah]", "GOBP_ECTOPIC_GERM_CELL_PROGRAMMED_CELL_DEATH": "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. [PMID:12814944]", "GOBP_EGG_ACTIVATION": "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. [GOC:bf, PMID:9630751]", "GOBP_ELASTIC_FIBER_ASSEMBLY": "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. [GOC:jid, PMID:10841810, PMID:12615674]", "GOBP_ELASTIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_ELASTIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue. [GOC:curators]", "GOBP_EMBRYONIC_BODY_MORPHOGENESIS": "The process in which the anatomical structures of the embryonic soma are generated and organized. [GOC:ems]", "GOBP_ELECTRON_TRANSPORT_CHAIN": "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. [GOC:mtg_electron_transport]", "GOBP_EMBRYONIC_APPENDAGE_MORPHOGENESIS": "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. [ISBN:0582227089]", "GOBP_EMBRYONIC_AXIS_SPECIFICATION": "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]", "GOBP_EMBRYONIC_BRAIN_DEVELOPMENT": "The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. [PMID:15918910]", "GOBP_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION": "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_EMBRYONIC_CLEAVAGE": "The first few specialized divisions of an activated animal egg. [GOC:clt, ISBN:0070524300]", "GOBP_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS": "The process in which the anatomical structures of the eye are generated and organized during embryonic development. [GOC:jid, GOC:mtg_sensu]", "GOBP_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT": "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. [GOC:mah, GOC:mtg_sensu]", "GOBP_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS": "The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. [GOC:dsf, GOC:jid, PMID:16049113]", "GOBP_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS": "The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:go_curators]", "GOBP_EMBRYONIC_FORELIMB_MORPHOGENESIS": "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. [ISBN:0198612001]", "GOBP_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT": "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. [GOC:go_curators]", "GOBP_EMBRYONIC_DIGIT_MORPHOGENESIS": "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. [GOC:bf, GOC:jl, UBERON:0002544]", "GOBP_EMBRYONIC_EYE_MORPHOGENESIS": "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. [GOC:jid]", "GOBP_EMBRYONIC_HEART_TUBE_LEFT_RIGHT_PATTERN_FORMATION": "The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place. [GOC:mtg_heart]", "GOBP_EMBRYONIC_HEMOPOIESIS": "The stages of blood cell formation that take place within the embryo. [GOC:bf]", "GOBP_EMBRYONIC_HEART_TUBE_DEVELOPMENT": "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. [GOC:go_curators]", "GOBP_EMBRYONIC_HEART_TUBE_MORPHOGENESIS": "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. [GOC:mtg_heart]", "GOBP_EMBRYONIC_HINDLIMB_MORPHOGENESIS": "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. [ISBN:0198612001]", "GOBP_EMBRYONIC_NEUROCRANIUM_MORPHOGENESIS": "The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain. [GOC:dsf, GOC:jid, PMID:16049113]", "GOBP_EMBRYONIC_PATTERN_SPECIFICATION": "The process that results in the patterns of cell differentiation that will arise in an embryo. [GOC:go_curators, ISBN:0521436125]", "GOBP_EMBRYONIC_MORPHOGENESIS": "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. [GOC:jid, GOC:mtg_sensu]", "GOBP_EMBRYONIC_PLACENTA_DEVELOPMENT": "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]", "GOBP_EMBRYONIC_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY": "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. [GOC:dph]", "GOBP_EMBRYONIC_PLACENTA_MORPHOGENESIS": "The process in which the embryonic placenta is generated and organized. [GOC:dph]", "GOBP_EMBRYONIC_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE": "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage. [GOC:dgh, GOC:dph]", "GOBP_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT": "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. [GOC:BHF, GOC:vk]", "GOBP_EMBRYONIC_ORGAN_MORPHOGENESIS": "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:jid]", "GOBP_EMBRYONIC_ORGAN_DEVELOPMENT": "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:jid]", "GOBP_EMBRYONIC_SKELETAL_JOINT_MORPHOGENESIS": "The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton. [GOC:bf, GOC:BHF, GOC:dph, UBERON:0000982]", "GOBP_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS": "The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]", "GOBP_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT": "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]", "GOBP_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS": "The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. [GOC:dsf, GOC:jid, PMID:16049113]", "GOBP_ENDOCARDIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:mtg_heart]", "GOBP_ENAMEL_MINERALIZATION": "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. [GOC:BHF, GOC:mah, GOC:sl, PMID:10206335, PMID:16931858, PMID:21196346]", "GOBP_ENDOCARDIAL_CUSHION_FORMATION": "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_heart, PMID:15797462]", "GOBP_EMBRYO_IMPLANTATION": "Attachment of the blastocyst to the uterine lining. [GOC:isa_complete, PMID:10882512]", "GOBP_ENDOCARDIAL_CUSHION_DEVELOPMENT": "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_heart]", "GOBP_ENDOCARDIAL_CUSHION_FUSION": "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping. [GOC:mtg_heart]", "GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING": "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]", "GOBP_EMBRYO_DEVELOPMENT": "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]", "GOBP_ENDOCARDIAL_CUSHION_TO_MESENCHYMAL_TRANSITION": "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:dph, GOC:tb]", "GOBP_ENDOCARDIAL_CUSHION_MORPHOGENESIS": "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. [GOC:mtg_heart]", "GOBP_ENDOCARDIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:mtg_heart]", "GOBP_ENDOCARDIUM_MORPHOGENESIS": "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:mtg_heart]", "GOBP_ENDOCHONDRAL_BONE_MORPHOGENESIS": "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. [GOC:dph, PMID:11680679]", "GOBP_ENDOCRINE_HORMONE_SECRETION": "The regulated release of a hormone into the circulatory system. [GOC:dph]", "GOBP_ENDOCRINE_PROCESS": "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. [ISBN:0721662544]", "GOBP_ENDOCRINE_PANCREAS_DEVELOPMENT": "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. [GOC:cvs]", "GOBP_ENDOCRINE_SYSTEM_DEVELOPMENT": "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. [GOC:bf, Wikipedia:Development_of_the_endocrine_system]", "GOBP_ENDOCYTOSIS_INVOLVED_IN_VIRAL_ENTRY_INTO_HOST_CELL": "Any endocytosis that is involved in the uptake of a virus into a host cell. [GOC:bf, GOC:jl, VZ:977]", "GOBP_ENDODERMAL_CELL_FATE_COMMITMENT": "The cell differentiation process that results in commitment of a cell to become part of the endoderm. [GOC:go_curators, ISBN:0878932437]", "GOBP_ENDODERMAL_CELL_FATE_SPECIFICATION": "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:go_curators]", "GOBP_ENDOCYTIC_RECYCLING": "The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. [PMID:16473635, PMID:23563491]", "GOBP_ENDODERM_DEVELOPMENT": "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. [GOC:dph, GOC:tb]", "GOBP_ENDOCYTOSIS": "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]", "GOBP_ENDODERM_FORMATION": "The formation of the endoderm during gastrulation. [GOC:go_curators]", "GOBP_ENDOLYSOSOMAL_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to an endolysosomal pattern recognition receptor (PRR) of the toll-like family. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. [PMID:29679565]", "GOBP_ENDONUCLEOLYTIC_CLEAVAGE_IN_5_ETS_OF_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA": "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. [GOC:curators, PMID:10690410, PMID:15282326]", "GOBP_ENDONUCLEOLYTIC_CLEAVAGE_IN_ITS1_TO_SEPARATE_SSU_RRNA_FROM_5_8S_RRNA_AND_LSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA": "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators, PMID:10690410]", "GOBP_ENDONUCLEOLYTIC_CLEAVAGE_OF_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA": "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae. [GOC:curators, PMID:10690410]", "GOBP_ENDOPLASMIC_RETICULUM_LOCALIZATION": "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]", "GOBP_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. [GOC:mah]", "GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. [GOC:mah, GOC:sm]", "GOBP_ENDOPLASMIC_RETICULUM_MEMBRANE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT": "The directed movement of substances from endoplasmic reticulum to cytosol. [GO_REF:0000076, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]", "GOBP_ENDOPLASMIC_RETICULUM_PLASMA_MEMBRANE_TETHERING": "The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684]", "GOBP_ENDOPLASMIC_RETICULUM_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK_FORMATION": "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. [GOC:mah, GOC:vw, PMID:16469703, PMID:20434336]", "GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT": "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]", "GOBP_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section. [GOC:vw, PMID:16469703, PMID:20434336]", "GOBP_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE": "", "GOBP_ENDOSOMAL_LUMEN_ACIDIFICATION": "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion. [GOC:jid]", "GOBP_ENDOSOMAL_VESICLE_FUSION": "The homotypic fusion of endocytic vesicles to form or add to an early endosome. [PMID:11964142, PMID:9422733]", "GOBP_ENDOSOMAL_TRANSPORT": "The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. [ISBN:0198506732]", "GOBP_ENDOSOME_TO_LYSOSOME_TRANSPORT_VIA_MULTIVESICULAR_BODY_SORTING_PATHWAY": "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome. [GOC:mah, PMID:12461556, PMID:16689637]", "GOBP_ENDOSOME_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_ENDOSOME_TRANSPORT_VIA_MULTIVESICULAR_BODY_SORTING_PATHWAY": "", "GOBP_ENDOSOME_TO_LYSOSOME_TRANSPORT": "The directed movement of substances from endosomes to lysosomes. [GOC:ai, ISBN:0716731363]", "GOBP_ENDOSOME_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT": "The directed movement of proteins from the endosome to the plasma membrane in transport vesicles. [GOC:dos]", "GOBP_ENDOTHELIAL_CELL_CHEMOTAXIS": "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [CL:0000115, GOC:BHF]", "GOBP_ENDOTHELIAL_CELL_ACTIVATION": "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484]", "GOBP_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]", "GOBP_ENDOTHELIAL_CELL_DEVELOPMENT": "The progression of an endothelial cell over time, from its formation to the mature structure. [GOC:dph]", "GOBP_ENDOTHELIAL_CELL_FATE_COMMITMENT": "The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_ENDOTHELIAL_CELL_MATRIX_ADHESION": "The binding of an endothelial cell to the extracellular matrix via adhesion molecules. [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962]", "GOBP_ENDOTHELIN_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10977869]", "GOBP_ENDOTHELIAL_CELL_MORPHOGENESIS": "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_ENERGY_COUPLED_PROTON_TRANSMEMBRANE_TRANSPORT_AGAINST_ELECTROCHEMICAL_GRADIENT": "", "GOBP_ENDOTHELIAL_CELL_MIGRATION": "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:go_curators]", "GOBP_ENGULFMENT_OF_APOPTOTIC_CELL": "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte. [GOC:rk, PMID:15536015]", "GOBP_ENDOTHELIAL_CELL_PROLIFERATION": "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. [GOC:add, ISBN:0781735149]", "GOBP_ENDOTHELIUM_DEVELOPMENT": "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. [GOC:mtg_heart]", "GOBP_ENERGY_HOMEOSTASIS": "Any process involved in the balance between food intake (energy input) and energy expenditure. [GOC:yaf, PMID:15919751]", "GOBP_ENERGY_RESERVE_METABOLIC_PROCESS": "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. [GOC:mah]", "GOBP_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS": "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. [GOC:mah]", "GOBP_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. [FMA:66070, GOC:jid, GOC:sr]", "GOBP_ENTEROENDOCRINE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. [CL:0000164, GOC:bf]", "GOBP_ENTRAINMENT_OF_CIRCADIAN_CLOCK": "The synchronization of a circadian rhythm to environmental time cues such as light. [GOC:jid]", "GOBP_ENSHEATHMENT_OF_NEURONS": "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. [GOC:dgh, GOC:dph, GOC:tb]", "GOBP_ENUCLEATE_ERYTHROCYTE_DEVELOPMENT": "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:devbiol]", "GOBP_ENTRY_OF_BACTERIUM_INTO_HOST_CELL": "", "GOBP_ENUCLEATE_ERYTHROCYTE_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. [GOC:go_curators]", "GOBP_ENUCLEATE_ERYTHROCYTE_DIFFERENTIATION": "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus. [GOC:go_curators]", "GOBP_EOSINOPHIL_ACTIVATION": "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:add, ISBN:0781735149]", "GOBP_EOSINOPHIL_MEDIATED_IMMUNITY": "Any process involved in the carrying out of an immune response by an eosinophil. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_EOSINOPHIL_DIFFERENTIATION": "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil. [GOC:add, GOC:mah]", "GOBP_EOSINOPHIL_MIGRATION": "The movement of an eosinophil within or between different tissues and organs of the body. [CL:0000771, GOC:BHF, GOC:mah]", "GOBP_EPHRIN_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]", "GOBP_EPIDERMAL_CELL_FATE_SPECIFICATION": "", "GOBP_EPIBOLY": "The expansion of one cell sheet over other cells or yolk. [GOC:dph, GOC:tb]", "GOBP_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]", "GOBP_EPIDERMAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]", "GOBP_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, ISBN:0815316194]", "GOBP_EPIDIDYMIS_DEVELOPMENT": "", "GOBP_EPIDERMIS_MORPHOGENESIS": "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:jid, UBERON:0001003]", "GOBP_EPIDERMIS_DEVELOPMENT": "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:go_curators, UBERON:0001003]", "GOBP_EPIGENETIC_PROGRAMING_OF_MALE_PRONUCLEUS": "", "GOBP_EPIGENETIC_PROGRAMMING_IN_THE_ZYGOTIC_PRONUCLEI": "The global programming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process. [GOC:sp, PMID:22868271]", "GOBP_EPINEPHRINE_SECRETION": "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system. [GOC:ef, GOC:jid]", "GOBP_EPIGENETIC_PROGRAMMING_OF_GENE_EXPRESSION": "A epigenetic process that happens during embryonic development that modulates gene expression potential at later stages of development of the organism, including the adult. Epigenetic regulation takes place via chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine DNA methylation. [GOC:go_curators, PMID:12138111, PMID:22868271]", "GOBP_EPINEPHRINE_TRANSPORT": "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jid]", "GOBP_EPITHELIAL_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in an epithelial cell. [GO_REF:0000085, GOC:TermGenie, PMID:19137015]", "GOBP_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION": "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]", "GOBP_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT": "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. [GOC:dph]", "GOBP_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236]", "GOBP_EPITHELIAL_CELL_CELL_ADHESION": "The attachment of an epithelial cell to another epithelial cell via adhesion molecules. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_EPITHELIAL_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. [GOC:dph]", "GOBP_EPITHELIAL_CELL_FATE_COMMITMENT": "The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. [GOC:mtg_kidney_jan10]", "GOBP_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_LUNG_MORPHOGENESIS": "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. [GOC:dph]", "GOBP_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751]", "GOBP_EPITHELIAL_CELL_MATURATION": "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. [GOC:dph]", "GOBP_EPITHELIAL_CELL_MORPHOGENESIS": "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT": "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time. [GOC:dph]", "GOBP_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS": "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland. [GOC:dph, PMID:17336109]", "GOBP_EPITHELIAL_CILIUM_MOVEMENT_INVOLVED_IN_DETERMINATION_OF_LEFT_RIGHT_ASYMMETRY": "The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves. [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579]", "GOBP_EPITHELIAL_FLUID_TRANSPORT": "The directed movement of fluid across epithelia. [GOC:jl, PMID:11390830]", "GOBP_EPITHELIAL_CELL_PROLIFERATION": "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. [ISBN:0721662544]", "GOBP_EPITHELIAL_MESENCHYMAL_CELL_SIGNALING": "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. [GOC:dph]", "GOBP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION": "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. [GOC:mtg_heart]", "GOBP_EPITHELIAL_STRUCTURE_MAINTENANCE": "A tissue homeostatic process required for the maintenance of epithelial structure. [GOC:dph, GOC:tb]", "GOBP_EPITHELIAL_TUBE_FORMATION": "", "GOBP_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS": "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. [GOC:dph, GOC:mtg_lung]", "GOBP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION": "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:dph, PMID:14701881]", "GOBP_EPOXIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers. [GOC:rs, PMID:15822179]", "GOBP_EPOXYGENASE_P450_PATHWAY": "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. [GOC:mah, PMID:17979511]", "GOBP_EQUILIBRIOCEPTION": "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion. [PMID:29303967]", "GOBP_ERBB2_EGFR_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. [GOC:signaling, PMID:16460914]", "GOBP_EPITHELIAL_TUBE_MORPHOGENESIS": "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. [GOC:dph]", "GOBP_ERAD_PATHWAY": "The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]", "GOBP_ERBB2_ERBB4_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4. [GOC:signaling, PMID:16460914]", "GOBP_ERBB2_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. [GOC:jc, PMID:16460914]", "GOBP_EPITHELIUM_DEVELOPMENT": "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:dph, GOC:mtg_lung]", "GOBP_ERBB3_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission. [GOC:jc, PMID:16460914]", "GOBP_ERBB4_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:16460914]", "GOBP_ERBB4_ERBB4_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:16460914]", "GOBP_ERBB_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:16460914, Wikipedia:ErbB]", "GOBP_ERROR_FREE_TRANSLESION_SYNTHESIS": "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. [GOC:elh]", "GOBP_ERK5_CASCADE": "A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development. [PMID:16376520, PMID:16880823, PMID:20811974, PMID:23125017, PMID:28903453]", "GOBP_ERK1_AND_ERK2_CASCADE": "A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development. [PMID:20811974, PMID:23125017, PMID:28903453]", "GOBP_ERROR_PRONE_TRANSLESION_SYNTHESIS": "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. [GOC:elh, GOC:jl, PMID:11485998]", "GOBP_ERYTHROCYTE_DEVELOPMENT": "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. [GOC:devbiol]", "GOBP_ERYTHROCYTE_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. [GOC:devbiol, GOC:jl]", "GOBP_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS": "", "GOBP_ER_NUCLEUS_SIGNALING_PATHWAY": "The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. [GOC:mah]", "GOBP_ERYTHROCYTE_HOMEOSTASIS": "Any process of regulating the production and elimination of erythrocytes within an organism. [GOC:add, PMID:10694114, PMID:14754397]", "GOBP_ER_OVERLOAD_RESPONSE": "The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB. [PMID:10390516]", "GOBP_ESCRT_COMPLEX_DISASSEMBLY": "The disaggregation of an ESCRT complex into its constituent components. [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109]", "GOBP_ESTABLISHMENT_OF_BLOOD_BRAIN_BARRIER": "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. [GOC:aruk, GOC:dph, GOC:sart, PMID:20080302, PMID:30280653]", "GOBP_ESTABLISHMENT_OF_BLOOD_RETINAL_BARRIER": "Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type. [PMID:25053619]", "GOBP_ESTABLISHMENT_OF_CENTROSOME_LOCALIZATION": "The directed movement of the centrosome to a specific location. [GOC:ai]", "GOBP_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER": "The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:krc, PMID:22155109]", "GOBP_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER": "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:dph]", "GOBP_ESTABLISHMENT_OF_CELL_POLARITY": "The specification and formation of anisotropic intracellular organization or cell growth patterns. [GOC:mah]", "GOBP_ESTABLISHMENT_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY": "The specification and formation of the apicobasal polarity of an epithelial cell. [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]", "GOBP_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY": "The specification and formation of anisotropic intracellular organization of an epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_ESTABLISHMENT_OF_GOLGI_LOCALIZATION": "The directed movement of the Golgi to a specific location. [GOC:ai]", "GOBP_ESTABLISHMENT_OF_LEFT_RIGHT_ASYMMETRY": "The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves. [GOC:BHF, PMID:18629866]", "GOBP_ESTABLISHMENT_OF_LYMPHOCYTE_POLARITY": "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. [GOC:mgi_curators, PMID:11244041, PMID:12615889]", "GOBP_ESTABLISHMENT_OF_MEIOTIC_SPINDLE_LOCALIZATION": "The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs. [GOC:ai]", "GOBP_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION": "The directed movement of the mitochondrion to a specific location. [GOC:ai]", "GOBP_ESTABLISHMENT_OF_MITOTIC_SISTER_CHROMATID_COHESION": "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle. [GOC:mah]", "GOBP_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION": "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. [GOC:ai]", "GOBP_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE": "", "GOBP_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION_MICROTUBULE_MEDIATED": "The directed movement of the mitochondrion to a specific location, by a process involving microtubules. [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220]", "GOBP_ESTABLISHMENT_OF_PIGMENT_GRANULE_LOCALIZATION": "The directed movement of a pigment granule to a specific location. [GOC:ai]", "GOBP_ESTABLISHMENT_OF_PLANAR_POLARITY_OF_EMBRYONIC_EPITHELIUM": "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates. [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb]", "GOBP_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL": "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]", "GOBP_ESTABLISHMENT_OF_ORGANELLE_LOCALIZATION": "The directed movement of an organelle to a specific location. [GOC:ai]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMATIN": "The directed movement of a protein to a part of a chromosome that is organized into chromatin. [GOC:mah]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME": "The directed movement of a protein to a specific location on a chromosome. [GOC:BHF, GOC:mah]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM": "The directed movement of a protein to a specific location in the endoplasmic reticulum. [GOC:mah]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRIAL_MEMBRANE": "The directed movement of a protein to a specific location in the mitochondrial membrane. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PEROXISOME": "The directed movement of a protein to a specific location in a peroxisome. [GOC:mah]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION": "The directed movement of a protein to a specific location. [GOC:bf]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE": "The directed movement of a protein to a specific location in a membrane. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_TELOMERE": "The directed movement of a protein to a specific location in the telomeric region of a chromosome. [GOC:BHF, GOC:mah]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE": "The directed movement of a protein to a specific location in a vacuole. [GOC:mah]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE": "The directed movement of a protein to a specific location in a plasma membrane. [GOC:dph, GOC:vw]", "GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE": "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. [GOC:mah]", "GOBP_ESTABLISHMENT_OF_SERTOLI_CELL_BARRIER": "Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions. [GOC:sl, PMID:19509333, Wikipedia:Blood-testis_barrier]", "GOBP_ESTABLISHMENT_OF_RNA_LOCALIZATION": "The directed movement of RNA to a specific location. [GOC:ai]", "GOBP_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION": "The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase. [GOC:jh, GOC:mah, PMID:14623866]", "GOBP_ESTABLISHMENT_OF_SKIN_BARRIER": "Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability. [GOC:dph]", "GOBP_ESTABLISHMENT_OF_TISSUE_POLARITY": "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. [GOC:jid]", "GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY": "Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. [GOC:dph, GOC:vw]", "GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_CYTOSKELETON_POLARITY": "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. [GOC:mah]", "GOBP_ESTABLISHMENT_OF_SPINDLE_ORIENTATION": "Any process that set the alignment of spindle relative to other cellular structures. [GOC:ai]", "GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT": "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. [GOC:mah, GOC:sm]", "GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY": "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. [GOC:dph, GOC:vw]", "GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY": "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. [GOC:mah]", "GOBP_ESTROGEN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]", "GOBP_ESTROGEN_METABOLIC_PROCESS": "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]", "GOBP_ESTROUS_CYCLE": "A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. [GOC:jl, Wikipedia:Estrous_cycle]", "GOBP_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "", "GOBP_ETHANOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732]", "GOBP_ETHER_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of ether. [GOC:pr, GOC:TermGenie]", "GOBP_ETHER_METABOLIC_PROCESS": "", "GOBP_EXCRETION": "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. [ISBN:0192801023]", "GOBP_EXCITATORY_CHEMICAL_SYNAPTIC_TRANSMISSION": "Synaptic transmission that results in an excitatory postsynaptic potential. [GOC:dos]", "GOBP_EXCITATORY_SYNAPSE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302]", "GOBP_EXECUTION_PHASE_OF_APOPTOSIS": "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:mtg_apoptosis, PMID:21760595]", "GOBP_EXOCRINE_PANCREAS_DEVELOPMENT": "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. [GOC:cvs]", "GOBP_EXIT_FROM_MITOSIS": "The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. [GOC:dph, GOC:tb]", "GOBP_EXOCYST_LOCALIZATION": "Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. [GOC:ai]", "GOBP_EXOCRINE_SYSTEM_DEVELOPMENT": "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. [GOC:bf, Wikipedia:Exocrine_gland]", "GOBP_EXOCYTIC_PROCESS": "The cellular processes that contribute to exocytosis. [Wikipedia:Exocytosis]", "GOBP_EXPLORATION_BEHAVIOR": "The specific behavior of an organism in response to a novel environment or stimulus. [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169]", "GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:pg]", "GOBP_EXOCYTOSIS": "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. [GOC:mah, ISBN:0716731363, PMID:22323285]", "GOBP_EXTRACELLULAR_EXOSOME_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458]", "GOBP_EXTRACELLULAR_MATRIX_CONSTITUENT_SECRETION": "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell. [GOC:mah]", "GOBP_EXTRACELLULAR_MATRIX_CELL_SIGNALING": "Any process that mediates the transfer of information between the extracellular matrix and a cell. [GOC:bf]", "GOBP_EXTRACELLULAR_MATRIX_ASSEMBLY": "The aggregation, arrangement and bonding together of the extracellular matrix. [GOC:jl]", "GOBP_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION": "Any regulation of signal transduction that takes place in the extracellular region. [GOC:signaling, GOC:TermGenie]", "GOBP_EXTRACELLULAR_MATRIX_DISASSEMBLY": "A process that results in the breakdown of the extracellular matrix. [GOC:jid]", "GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]", "GOBP_EXTRACELLULAR_VESICLE_BIOGENESIS": "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. [PMID:28736435]", "GOBP_EXTRACELLULAR_TRANSPORT": "The transport of substances that occurs outside cells. [GOC:go_curators]", "GOBP_EXTRAEMBRYONIC_MEMBRANE_DEVELOPMENT": "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584]", "GOBP_EXPORT_FROM_CELL": "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. [GOC:pg]", "GOBP_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE": "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. [GOC:dph, GOC:yaf]", "GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS": "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. [GOC:mah, GOC:mtg_apoptosis]", "GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]", "GOBP_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT": "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. [GOC:jl, ISBN:0192800981]", "GOBP_EYE_PIGMENTATION": "Establishment of a pattern of pigment in the eye of an organism. [GOC:jid]", "GOBP_FACE_MORPHOGENESIS": "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. [GOC:dph]", "GOBP_EYE_MORPHOGENESIS": "The process in which the anatomical structures of the eye are generated and organized. [GOC:jid, GOC:mtg_sensu]", "GOBP_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. [GOC:go_curators]", "GOBP_FACE_DEVELOPMENT": "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. [GOC:dph]", "GOBP_FACIAL_NERVE_MORPHOGENESIS": "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_FACIAL_NERVE_STRUCTURAL_ORGANIZATION": "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_FACULTATIVE_HETEROCHROMATIN_FORMATION": "The compaction of chromatin into a conformation that is refractory to transcription but that can be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression). In metazoa, this involves the methylation of histone H3K27. [PMID:17936700]", "GOBP_FARNESYL_DIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation. [GOC:go_curators]", "GOBP_FAS_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily. [GOC:nhn, PMID:12040174, Wikipedia:Fas_receptor]", "GOBP_FATTY_ACID_ALPHA_OXIDATION": "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway. [PMID:10198260]", "GOBP_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE": "A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:FAO-PWY]", "GOBP_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE": "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, MetaCyc:PWY-5136]", "GOBP_FATTY_ACID_BETA_OXIDATION": "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). [GOC:mah, ISBN:0198506732]", "GOBP_FATTY_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:mah, ISBN:0198506732]", "GOBP_FATTY_ACID_DERIVATIVE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of fatty acid derivative. [GOC:pr, GOC:TermGenie]", "GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS": "The chemical reactions and pathways involving fatty acid derivative. [GOC:pr, GOC:TermGenie]", "GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of fatty acid derivative. [GOC:pr, GOC:TermGenie]", "GOBP_FATTY_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:go_curators]", "GOBP_FATTY_ACID_ELONGATION": "The elongation of a fatty acid chain by the sequential addition of two-carbon units. [ISBN:0716720094]", "GOBP_FATTY_ACID_ELONGATION_SATURATED_FATTY_ACID": "Elongation of a saturated fatty acid chain. [GOC:mah]", "GOBP_FATTY_ACID_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. [GOC:BHF, GOC:rl]", "GOBP_FATTY_ACID_OMEGA_OXIDATION": "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation. [MetaCyc:PWY-2724, PMID:16404574]", "GOBP_FATTY_ACID_TRANSMEMBRANE_TRANSPORT": "The process in which a fatty acid is transported across a membrane. [GOC:rb, GOC:TermGenie, PMID:9395310]", "GOBP_FATTY_ACYL_COA_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. [ISBN:0198506732]", "GOBP_FATTY_ACID_TRANSPORT": "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [GOC:ai]", "GOBP_FATTY_ACYL_COA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. [PMID:10578051]", "GOBP_FAT_CELL_PROLIFERATION": "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. [GOC:mah, GOC:sl]", "GOBP_FATTY_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]", "GOBP_FATTY_ACYL_COA_METABOLIC_PROCESS": "The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. [ISBN:0198506732]", "GOBP_FAT_PAD_DEVELOPMENT": "The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue. [GOC:dph]", "GOBP_FAT_SOLUBLE_VITAMIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. [GOC:jl, ISBN:0198506732]", "GOBP_FAT_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. [CL:0000136, GOC:go_curators]", "GOBP_FAT_SOLUBLE_VITAMIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. [GOC:jl, ISBN:0198506732]", "GOBP_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS": "", "GOBP_FC_RECEPTOR_MEDIATED_INHIBITORY_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:add, ISBN:0781735149]", "GOBP_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:phg, PMID:12413516, PMID:15048725]", "GOBP_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:phg, PMID:11244038]", "GOBP_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_FC_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:phg, Wikipedia:Fc_receptor]", "GOBP_FEAR_RESPONSE": "The response of an organism to a perceived external threat. [GOC:go_curators]", "GOBP_FEMALE_GENITALIA_DEVELOPMENT": "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. [GOC:mah]", "GOBP_FEEDING_BEHAVIOR": "Behavior associated with the intake of food. [GOC:mah]", "GOBP_FEMALE_MEIOSIS_CHROMOSOME_SEGREGATION": "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. [GOC:ai]", "GOBP_FEMALE_GAMETE_GENERATION": "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. [GOC:dph, ISBN:0198506732]", "GOBP_FEMALE_MEIOSIS_I": "The cell cycle process in which the first meiotic division occurs in the female germline. [GOC:mah]", "GOBP_FEMALE_MEIOTIC_NUCLEAR_DIVISION": "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. [GOC:dph, GOC:ems, GOC:mah, GOC:vw]", "GOBP_FERMENTATION": "The metabolic process that uses oxidation-reduction reactions of organic compounds and substrate-level phosphorylation for the generation of adenosine triphosphate (ATP), without consuming oxygen and is independent of electron transport chains. [PMID:25617754, PMID:38821505]", "GOBP_FEMALE_SEX_DIFFERENTIATION": "The establishment of the sex of a female organism by physical differentiation. [GOC:bf]", "GOBP_FIBRINOLYSIS": "A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. [GOC:jl, PMID:15842654]", "GOBP_FERROPTOSIS": "A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes. [GOC:mtg_apoptosis, PMID:25236395, PMID:26794443]", "GOBP_FEVER_GENERATION": "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection. [GOC:dph, GOC:jl]", "GOBP_FIBROBLAST_ACTIVATION": "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. [CL:0000057, GOC:BHF, GOC:mah]", "GOBP_FERTILIZATION": "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). [GOC:tb, ISBN:0198506732]", "GOBP_FIBROBLAST_APOPTOTIC_PROCESS": "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]", "GOBP_FIBROBLAST_GROWTH_FACTOR_PRODUCTION": "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]", "GOBP_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GOC:ceb]", "GOBP_FIBROBLAST_MIGRATION": "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_FIBROBLAST_PROLIFERATION": "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. [GOC:jid]", "GOBP_FLAVIN_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. [GOC:jl, GOC:mah]", "GOBP_FILOPODIUM_ASSEMBLY": "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]", "GOBP_FLAVONE_METABOLIC_PROCESS": "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). [PMID:18567791]", "GOBP_FLOOR_PLATE_DEVELOPMENT": "The progression of the floor plate over time from its initial formation until its mature state. [GOC:dh]", "GOBP_FLAVONOID_GLUCURONIDATION": "", "GOBP_FLAVONOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. [GOC:tair_curators, ISBN:0198547684]", "GOBP_FOAM_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]", "GOBP_FOLATE_TRANSMEMBRANE_TRANSPORT": "", "GOBP_FLUID_TRANSPORT": "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_FOCAL_ADHESION_ASSEMBLY": "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. [GOC:jid, GOC:mah]", "GOBP_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. [GOC:ai]", "GOBP_FOLIC_ACID_CONTAINING_COMPOUND_CATABOLIC_PROCESS": "", "GOBP_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. [GOC:ai, GOC:mah]", "GOBP_FOLIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [ISBN:0198506732]", "GOBP_FOLIC_ACID_TRANSPORT": "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:ai]", "GOBP_FOLLICLE_STIMULATING_HORMONE_SECRETION": "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. [ISBN:0198506732]", "GOBP_FOREBRAIN_CELL_MIGRATION": "The orderly movement of a cell from one site to another at least one of which is located in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_FOREBRAIN_DORSAL_VENTRAL_PATTERN_FORMATION": "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_FOREBRAIN_MORPHOGENESIS": "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_FOREBRAIN_NEUROBLAST_DIVISION": "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_FOREBRAIN_GENERATION_OF_NEURONS": "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_FOREBRAIN_NEURON_DIFFERENTIATION": "", "GOBP_FOREBRAIN_NEURON_DEVELOPMENT": "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_FOREBRAIN_NEURON_FATE_COMMITMENT": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]", "GOBP_FOREBRAIN_RADIAL_GLIAL_CELL_DIFFERENTIATION": "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]", "GOBP_FOREBRAIN_DEVELOPMENT": "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). [PMID:4975589, PMID:4992177]", "GOBP_FOREBRAIN_VENTRICULAR_ZONE_PROGENITOR_CELL_DIVISION": "The mitotic division of a basal progenitor giving rise to two neurons. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]", "GOBP_FOREBRAIN_REGIONALIZATION": "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:16226447]", "GOBP_FOREGUT_MORPHOGENESIS": "The process in which the anatomical structures of the foregut are generated and organized. [GOC:jid]", "GOBP_FORMATION_OF_ANATOMICAL_BOUNDARY": "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GO_REF:0000021]", "GOBP_FORMATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. [ISBN:0198506732]", "GOBP_FORELIMB_MORPHOGENESIS": "The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. [GOC:go_curators]", "GOBP_FORMATION_OF_CYTOPLASMIC_TRANSLATION_INITIATION_COMPLEX": "Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. [GOC:hjd, PMID:29735639]", "GOBP_FORMATION_OF_EXTRACHROMOSOMAL_CIRCULAR_DNA": "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats. [GOC:jh, PMID:12044938]", "GOBP_FORMATION_OF_QUADRUPLE_SL_U4_U5_U6_SNRNP": "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA. [GOC:krc, ISBN:0879695897]", "GOBP_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX": "The joining of the small ribosomal subunit, ternary complex, and mRNA. [GOC:hjd]", "GOBP_FORMATION_OF_PRIMARY_GERM_LAYER": "The formation of the ectoderm, mesoderm and endoderm during gastrulation. [GOC:go_curators]", "GOBP_FREE_UBIQUITIN_CHAIN_POLYMERIZATION": "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_FRUCTOSE_2_6_BISPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. [ISBN:0198506732]", "GOBP_FRUCTOSE_1_6_BISPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. [ISBN:0198506732]", "GOBP_FRUCTOSE_6_PHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. [ISBN:0198506732]", "GOBP_FRUCTOSE_METABOLIC_PROCESS": "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [ISBN:0198506732]", "GOBP_FUCOSE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose). [GOC:jl]", "GOBP_FRUCTOSE_TRANSMEMBRANE_TRANSPORT": "The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [GOC:ai]", "GOBP_FUCOSE_METABOLIC_PROCESS": "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. [ISBN:0198506732]", "GOBP_FUCOSYLATION": "", "GOBP_FUNGIFORM_PAPILLA_MORPHOGENESIS": "The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue. [GOC:dph]", "GOBP_FUSED_ANTRUM_STAGE": "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space. [GOC:jid, GOC:mtg_sensu, ISBN:0198542771]", "GOBP_FUNGIFORM_PAPILLA_DEVELOPMENT": "The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue. [GOC:dph]", "GOBP_G0_TO_G1_TRANSITION": "The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. [GOC:mtg_cell_cycle, ISBN:0716731363]", "GOBP_G1_TO_G0_TRANSITION": "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence. [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194]", "GOBP_G1_TO_G0_TRANSITION_INVOLVED_IN_CELL_DIFFERENTIATION": "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation. [GOC:mah, ISBN:0815316194]", "GOBP_G2_MI_TRANSITION_OF_MEIOTIC_CELL_CYCLE": "The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I. [PMID:15084480]", "GOBP_GABAERGIC_NEURON_DIFFERENTIATION": "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. [GOC:kmv, PMID:11517269]", "GOBP_GALACTOLIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. [ISBN:0198506732]", "GOBP_GALACTOSE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose. [ISBN:0198506732]", "GOBP_GALACTOSE_METABOLIC_PROCESS": "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. [ISBN:0198506732]", "GOBP_GALACTOSE_TRANSMEMBRANE_TRANSPORT": "The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. [GOC:ai]", "GOBP_GALACTOSYLCERAMIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of galactosylceramides, any composed of a ceramide backbone covalently linked to a galactose. The galactose can be sulfated or further elongated with one more monosaccharide often a sialic acid. [PMID:34071409]", "GOBP_GALACTOSE_CATABOLIC_PROCESS_VIA_UDP_GALACTOSE": "", "GOBP_GAMETE_GENERATION": "", "GOBP_GAMMA_AMINOBUTYRIC_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [GOC:ai]", "GOBP_GAMMA_AMINOBUTYRIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [ISBN:0198506732]", "GOBP_GAMMA_AMINOBUTYRIC_ACID_IMPORT": "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle. [GOC:ai]", "GOBP_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY": "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell. [GOC:mah]", "GOBP_GAMMA_AMINOBUTYRIC_ACID_SECRETION": "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues. [GOC:ef]", "GOBP_GAMMA_AMINOBUTYRIC_ACID_TRANSPORT": "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]", "GOBP_GAMMA_DELTA_T_CELL_ACTIVATION": "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:add]", "GOBP_GANGLION_DEVELOPMENT": "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. [GOC:dph]", "GOBP_GAMMA_DELTA_T_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex. [CL:0000798, GOC:jl]", "GOBP_GANGLIOSIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of gangliosides that begins with the synthesis of a tetrasaccharide core Gal-beta-1,3-GalNAc-beta-1,4-Gal-beta-1,4-Glc-ceramide. This core can be further elongated with the sequential addition of various carbohydrate units including the addition of one or more sialic acid residues. [PMID:35536927]", "GOBP_GANGLIOSIDE_BIOSYNTHETIC_PROCESS_VIA_LACTOSYLCERAMIDE": "", "GOBP_GANGLIOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. [ISBN:0198506732]", "GOBP_GANGLIOSIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. [ISBN:0198547684]", "GOBP_GAP_JUNCTION_ASSEMBLY": "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids. [GOC:jid, ISBN:0716731363]", "GOBP_GAP_JUNCTION_MEDIATED_INTERCELLULAR_TRANSPORT": "The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells. [GOC:hjd, PMID:14506308, PMID:23261543, Wikipedia:Gap_junction]", "GOBP_GASTRIC_MOTILITY": "The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum. [GOC:cy, ISBN:9781416032458, PMID:16139031]", "GOBP_GASTRIC_ACID_SECRETION": "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. [GOC:hjd]", "GOBP_GASTRO_INTESTINAL_SYSTEM_SMOOTH_MUSCLE_CONTRACTION": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). [GOC:mtg_muscle, MA:0001523, MSH:D041981]", "GOBP_GAS_TRANSPORT": "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_GASTRULATION_WITH_MOUTH_FORMING_SECOND": "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. [GOC:go_curators, GOC:mtg_sensu]", "GOBP_GASTRULATION": "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. [GOC:curators, ISBN:9780878933846]", "GOBP_GDP_METABOLIC_PROCESS": "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. [GOC:ai]", "GOBP_GDP_MANNOSE_METABOLIC_PROCESS": "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. [GOC:ai]", "GOBP_GENERAL_ADAPTATION_SYNDROME": "General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses. [PMID:14847556, Wikipedia:General_adaptation_syndrome]", "GOBP_GENERAL_ADAPTATION_SYNDROME_BEHAVIORAL_PROCESS": "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus. [GOC:ai]", "GOBP_GENITALIA_MORPHOGENESIS": "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. [GOC:bf]", "GOBP_GENITALIA_DEVELOPMENT": "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. [GOC:jid]", "GOBP_GENOMIC_IMPRINTING": "The establishment of epigenetic modifications (imprints) during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation. [PMID:24492710, PMID:31896690, PMID:31965998]", "GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY": "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. [GOC:jl]", "GOBP_GEPHYRIN_CLUSTERING_INVOLVED_IN_POSTSYNAPTIC_DENSITY_ASSEMBLY": "The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses. [GOC:BHF, GOC:sjp, PMID:15620359, PMID:24552784, PMID:25772192]", "GOBP_GERMINAL_CENTER_FORMATION": "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation. [GO_REF:0000022, GOC:jal, ISBN:081533642X]", "GOBP_GERMINAL_CENTER_B_CELL_DIFFERENTIATION": "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). [GOC:jal, ISBN:0781735149]", "GOBP_GERM_CELL_PROLIFERATION": "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. [CL:0000586, GOC:kmv]", "GOBP_GERM_CELL_MIGRATION": "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. [GOC:bf, GOC:jl]", "GOBP_GENERATION_OF_NEURONS": "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. [GOC:nln]", "GOBP_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT": "", "GOBP_GLANDULAR_EPITHELIAL_CELL_MATURATION": "", "GOBP_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. [GOC:dph]", "GOBP_GLIAL_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. [CL:0000125, GOC:mtg_apoptosis, GOC:sart]", "GOBP_GLAND_MORPHOGENESIS": "The process in which the anatomical structures of a gland are generated and organized. [GOC:isa_complete]", "GOBP_GLIAL_CELL_DERIVED_NEUROTROPHIC_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a glial cell-derived neurotrophic factor receptor. [GOC:yaf, PMID:12953054, PMID:29245123]", "GOBP_GLIAL_CELL_ACTIVATION": "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:aruk, GOC:bc, PMID:18723082]", "GOBP_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. [GOC:jid]", "GOBP_GLIAL_CELL_DEVELOPMENT": "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_GLIAL_CELL_FATE_COMMITMENT": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_GLIAL_CELL_FATE_SPECIFICATION": "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_GLIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. [GOC:go_curators, GOC:mtg_sensu]", "GOBP_GLIAL_CELL_MIGRATION": "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. [GOC:jl, GOC:mtg_sensu]", "GOBP_GLOMERULAR_MESANGIAL_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]", "GOBP_GLOMERULAR_MESANGIAL_CELL_PROLIFERATION": "The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population. [GOC:mtg_kidney_jan10]", "GOBP_GLOMERULAR_MESANGIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus. [GOC:mtg_kidney_jan10]", "GOBP_GLIOGENESIS": "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. [GOC:dgh, GOC:jid]", "GOBP_GLOMERULAR_EPITHELIAL_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. [GOC:mtg_kidney_jan10]", "GOBP_GLOMERULAR_BASEMENT_MEMBRANE_DEVELOPMENT": "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration. [GOC:sr]", "GOBP_GLOMERULAR_ENDOTHELIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus. [GOC:mtg_kidney_jan10]", "GOBP_GLOMERULAR_EPITHELIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_GLIAL_CELL_PROLIFERATION": "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. [GOC:ef, ISBN:0878932585]", "GOBP_GLOMERULUS_DEVELOPMENT": "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. [GOC:mah, GOC:mtg_kidney_jan10]", "GOBP_GLOMERULUS_MORPHOGENESIS": "The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. [GOC:mtg_kidney_jan10]", "GOBP_GLOMERULUS_VASCULATURE_MORPHOGENESIS": "The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus. [GOC:mtg_kidney_jan10]", "GOBP_GLOSSOPHARYNGEAL_NERVE_DEVELOPMENT": "", "GOBP_GLUCOCORTICOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [ISBN:0198506732]", "GOBP_GLUCAN_METABOLIC_PROCESS": "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. [GOC:jl]", "GOBP_GLUCAN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. [GOC:go_curators]", "GOBP_GLUCOCORTICOID_SECRETION": "The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood. [GOC:sl]", "GOBP_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "", "GOBP_GLUCOSAMINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines). [GOC:TermGenie]", "GOBP_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]", "GOBP_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. [GOC:ai]", "GOBP_GLUCOSE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. [GOC:ai]", "GOBP_GLUCOSE_IMPORT": "", "GOBP_GLUCOSE_IMPORT_ACROSS_PLASMA_MEMBRANE": "", "GOBP_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS": "The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus. [GOC:BHF, PMID:19079291]", "GOBP_GLUCOSYLCERAMIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. [GOC:ai]", "GOBP_GLUCOSE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732]", "GOBP_GLUTAMATE_CATABOLIC_PROCESS": "", "GOBP_GLUCURONATE_CATABOLIC_PROCESS_TO_XYLULOSE_5_PHOSPHATE": "", "GOBP_GLUCOSYLCERAMIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative. [ISBN:0198506732]", "GOBP_GLUTAMATERGIC_NEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron. [GO_REF:0000086, GOC:TermGenie, PMID:24030726]", "GOBP_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:9131252]", "GOBP_GLUTAMATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. [GOC:go_curators]", "GOBP_GLUTAMATE_SECRETION": "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. [GOC:ef]", "GOBP_GLUTAMATE_REUPTAKE": "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387, Wikipedia:Glutamate_transporter]", "GOBP_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. [GOC:ai]", "GOBP_GLUTAMATE_SECRETION_NEUROTRANSMISSION": "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter. [GOC:dph]", "GOBP_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS": "", "GOBP_GLUTAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. [GOC:ai]", "GOBP_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. [GOC:ai]", "GOBP_GLUTATHIONE_TRANSMEMBRANE_TRANSPORT": "A process in which glutathione is transported across a membrane. [GOC:mah]", "GOBP_GLUTAMINE_TRANSPORT": "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_GLUTATHIONE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. [GOC:ai, ISBN:0198506732]", "GOBP_GLUTATHIONE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. [ISBN:0198506732]", "GOBP_GLUTATHIONE_TRANSPORT": "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. [GOC:ai, ISBN:0198506732]", "GOBP_GLYCEROLIPID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. [GOC:ai]", "GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. [GOC:ai]", "GOBP_GLYCEROL_3_PHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. [GOC:go_curators, ISBN:0198506732]", "GOBP_GLYCEROL_ETHER_METABOLIC_PROCESS": "", "GOBP_GLYCEROL_TRANSMEMBRANE_TRANSPORT": "The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:ai]", "GOBP_GLYCINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. [GOC:go_curators]", "GOBP_GLYCEROLIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. [GOC:ai, PMID:8906569]", "GOBP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. [ISBN:0198506732]", "GOBP_GLYCINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycine, aminoethanoic acid. [GOC:go_curators]", "GOBP_GLYCINE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]", "GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. [ISBN:0198506732]", "GOBP_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. [ISBN:0198506732]", "GOBP_GLYCINE_TRANSPORT": "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_GLYCOLIPID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). [GOC:go_curators]", "GOBP_GLYCOLIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). [GOC:go_curators]", "GOBP_GLYCOLYTIC_PROCESS_THROUGH_FRUCTOSE_6_PHOSPHATE": "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH. [GOC:dph, ISBN:0201090910, ISBN:0879010479]", "GOBP_GLYCOLIPID_TRANSPORT": "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_GLYCOPHAGY": "The selective degradation of glycogen by macroautophagy. [GOC:autophagy, PMID:21893048]", "GOBP_GLYCOLYTIC_PROCESS_THROUGH_GLUCOSE_6_PHOSPHATE": "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP. [GOC:dph, ISBN:0201090910, ISBN:0879010479]", "GOBP_GLYCOSAMINOGLYCAN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units. [PMID:38500384]", "GOBP_GLYCOPROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]", "GOBP_GLYCOSIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. [GOC:go_curators]", "GOBP_GLYCOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. [ISBN:0198547684]", "GOBP_GLYCOSIDE_TRANSPORT": "The directed movement of a glycoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:pr, GOC:TermGenie]", "GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [PMID:35536965]", "GOBP_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a glycosphingolipid, a compound composed of a ceramide backbone covalently linked to at least one carbohydrate moiety. [PMID:35536927]", "GOBP_GLYCOPROTEIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]", "GOBP_GLYCOSYLATION": "", "GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. [ISBN:0198547684]", "GOBP_GLYCOSYLCERAMIDE_BIOSYNTHETIC_PROCESS": "", "GOBP_GLYCOSYLCERAMIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. [GOC:ai]", "GOBP_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of glycosyl compound. [GOC:pr, GOC:TermGenie]", "GOBP_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of glycosyl compound. [GOC:pr, GOC:TermGenie]", "GOBP_GLYCOSYLCERAMIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. [GOC:ai, ISBN:0198506732]", "GOBP_GMP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. [ISBN:0198506732]", "GOBP_GLYOXYLATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. [ISBN:0198506732]", "GOBP_GLYCOSYL_COMPOUND_METABOLIC_PROCESS": "", "GOBP_GMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving GMP, guanosine monophosphate. [GOC:go_curators]", "GOBP_GOLGI_DISASSEMBLY": "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_GOLGI_LOCALIZATION": "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]", "GOBP_GMP_SALVAGE": "", "GOBP_GOLGI_LUMEN_ACIDIFICATION": "Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion. [GOC:dph, PMID:23447592]", "GOBP_GOLGI_RIBBON_FORMATION": "The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_GOLGI_TO_ENDOSOME_TRANSPORT": "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. [GOC:jl, ISBN:0716731363, PMID:10873832]", "GOBP_GOLGI_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_GOLGI_TO_LYSOSOME_TRANSPORT": "The directed movement of substances from the Golgi to lysosomes. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_GOLGI_TO_VACUOLE_TRANSPORT": "The directed movement of substances from the Golgi to the vacuole. [GOC:ai]", "GOBP_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT": "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. [ISBN:0716731363]", "GOBP_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT": "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. [ISBN:0716731363]", "GOBP_GOLGI_VESICLE_BUDDING": "The evagination of the Golgi membrane, resulting in formation of a vesicle. [GOC:jid, ISBN:0716731363, PMID:10219233]", "GOBP_GONADAL_MESODERM_DEVELOPMENT": "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. [GOC:ai]", "GOBP_GONADOTROPIN_SECRETION": "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone. [GOC:mah, ISBN:0721662544]", "GOBP_GOLGI_VESICLE_TRANSPORT": "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. [GOC:jid, ISBN:0716731363, PMID:10219233]", "GOBP_GRANULOCYTE_ACTIVATION": "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [CL:0000094, GOC:nhn]", "GOBP_GPI_ANCHOR_METABOLIC_PROCESS": "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. [ISBN:0198506732]", "GOBP_GRANULOCYTE_COLONY_STIMULATING_FACTOR_PRODUCTION": "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]", "GOBP_GRANULOCYTE_COLONY_STIMULATING_FACTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R). [GOC:nhn, GOC:signaling]", "GOBP_GRANULOCYTE_CHEMOTAXIS": "The movement of a granulocyte in response to an external stimulus. [GOC:rph]", "GOBP_GRANULOCYTE_DIFFERENTIATION": "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm]", "GOBP_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION": "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, ISBN:0198506732]", "GOBP_GRANZYME_MEDIATED_PROGRAMMED_CELL_DEATH_SIGNALING_PATHWAY": "The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells. [PMID:32299851]", "GOBP_GRANULOCYTE_MIGRATION": "The movement of a granulocyte within or between different tissues and organs of the body. [GOC:cvs, PMID:24163421, PMID:24193336]", "GOBP_GROOMING_BEHAVIOR": "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. [GOC:jl, GOC:pr]", "GOBP_GROWTH_HORMONE_RECEPTOR_SIGNALING_PATHWAY_VIA_JAK_STAT": "The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. [GOC:BHF, GOC:dph, PMID:11445442]", "GOBP_GROWTH_INVOLVED_IN_HEART_MORPHOGENESIS": "Developmental growth that contributes to the shaping of the heart. [GOC:mtg_heart]", "GOBP_GROWTH_PLATE_CARTILAGE_CHONDROCYTE_DEVELOPMENT": "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_GROWTH_HORMONE_SECRETION": "The regulated release of growth hormone from secretory granules into the blood. [GOC:mah]", "GOBP_GROWTH_PLATE_CARTILAGE_CHONDROCYTE_DIFFERENTIATION": "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_GTP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. [ISBN:0198506732]", "GOBP_GROWTH_PLATE_CARTILAGE_DEVELOPMENT": "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_GTP_METABOLIC_PROCESS": "The chemical reactions and pathways involving GTP, guanosine triphosphate. [GOC:go_curators]", "GOBP_GUANINE_NUCLEOTIDE_TRANSPORT": "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mcc]", "GOBP_GUANINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. [GOC:go_curators]", "GOBP_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription. [GOC:mah, ISBN:0815316194]", "GOBP_GROWTH": "The increase in size or mass of an entire organism, a part of an organism or a cell. [GOC:bf, GOC:ma]", "GOBP_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling, PMID:9131252]", "GOBP_G_PROTEIN_COUPLED_OPIOID_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bf, PMID:20494127]", "GOBP_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, PMID:9755289]", "GOBP_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by an extracellular purine or purine derivative binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, PMID:9755289]", "GOBP_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION": "The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle. [PMID:8396717]", "GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_PROCESS": "", "GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]", "GOBP_G_PROTEIN_COUPLED_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands. [GOC:mah]", "GOBP_HAIR_CYCLE_PHASE": "", "GOBP_G_QUADRUPLEX_DNA_UNWINDING": "", "GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]", "GOBP_HAIR_FOLLICLE_PLACODE_FORMATION": "The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_HAIR_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a hair cell. [GOC:bf]", "GOBP_HAIR_FOLLICLE_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state. [GOC:devbiol]", "GOBP_HARD_PALATE_DEVELOPMENT": "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes. [GOC:dph, ISBN:0721662544]", "GOBP_HEAD_MORPHOGENESIS": "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. [GOC:dph]", "GOBP_HEAD_DEVELOPMENT": "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. [GOC:dph]", "GOBP_HEART_FORMATION": "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. [GOC:mtg_heart]", "GOBP_HEART_FIELD_SPECIFICATION": "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop. [GOC:mtg_heart]", "GOBP_HEART_DEVELOPMENT": "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]", "GOBP_HEART_TRABECULA_FORMATION": "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]", "GOBP_HEART_GROWTH": "The increase in size or mass of the heart. [GOC:dph, GOC:tb]", "GOBP_HEART_TRABECULA_MORPHOGENESIS": "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. [GOC:dph]", "GOBP_HEART_MORPHOGENESIS": "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:dph, GOC:isa_complete]", "GOBP_HEART_PROCESS": "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:mtg_cardio]", "GOBP_HEART_VALVE_FORMATION": "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. [GOC:mtg_heart]", "GOBP_HEART_VALVE_DEVELOPMENT": "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. [GOC:mtg_heart]", "GOBP_HEAT_ACCLIMATION": "Any process that increases heat tolerance of an organism in response to high temperatures. [GOC:tair_curators]", "GOBP_HEART_VALVE_MORPHOGENESIS": "The process in which the structure of a heart valve is generated and organized. [GOC:mtg_heart]", "GOBP_HEAT_GENERATION": "Any homeostatic process in which an organism produces heat, thereby raising its internal temperature. [GOC:mah]", "GOBP_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION": "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]", "GOBP_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083]", "GOBP_HEMATOPOIETIC_OR_LYMPHOID_ORGAN_DEVELOPMENT": "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. [GOC:add, GOC:rl, ISBN:0781735149]", "GOBP_HEMATOPOIETIC_STEM_CELL_HOMEOSTASIS": "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. [GOC:dph, PMID:21508411]", "GOBP_HEMATOPOIETIC_STEM_CELL_MIGRATION": "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. [CL:0000037, GOC:BHF, PMID:20234092]", "GOBP_HEMATOPOIETIC_STEM_CELL_MIGRATION_TO_BONE_MARROW": "The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. [CL:0000037, GOC:yaf, PMID:17368745]", "GOBP_HEME_A_METABOLIC_PROCESS": "", "GOBP_HEME_TRANSPORT": "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_HEME_B_METABOLIC_PROCESS": "", "GOBP_HEMATOPOIETIC_STEM_CELL_PROLIFERATION": "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl]", "GOBP_HEMOGLOBIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:jl]", "GOBP_HEMIDESMOSOME_ASSEMBLY": "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. [GOC:dgh, PMID:15983403]", "GOBP_HEMOGLOBIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. [GOC:go_curators, GOC:jl]", "GOBP_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS_ENZYMATIC_MODIFICATION": "", "GOBP_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate). [PMID:27241222]", "GOBP_HEMOSTASIS": "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. [ISBN:0198506732]", "GOBP_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS_POLYSACCHARIDE_CHAIN_BIOSYNTHETIC_PROCESS": "", "GOBP_HEPARAN_SULFATE_PROTEOGLYCAN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. [PMID:35536982]", "GOBP_HEMOPOIESIS": "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. [GOC:dgh, ISBN:0198506732]", "GOBP_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS": "The chemical reactions and pathways involving heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. [PMID:27241222]", "GOBP_HEPARIN_METABOLIC_PROCESS": "", "GOBP_HEPARIN_BIOSYNTHETIC_PROCESS": "", "GOBP_HEPATIC_STELLATE_CELL_ACTIVATION": "A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor. [CL:0000632, GOC:bf]", "GOBP_HEPATICOBILIARY_SYSTEM_DEVELOPMENT": "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. [GOC:dph]", "GOBP_HEPATOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. [CL:0000182, PMID:7588884]", "GOBP_HEPATOCYTE_APOPTOTIC_PROCESS": "Any apoptotic process in a hepatocyte, the main structural component of the liver. [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020]", "GOBP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]", "GOBP_HEPOXILIN_METABOLIC_PROCESS": "", "GOBP_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES": "", "GOBP_HETEROCHROMATIN_FORMATION": "", "GOBP_HETEROTYPIC_CELL_CELL_ADHESION": "The attachment of a cell to a cell of a different type via adhesion molecules. [GOC:add]", "GOBP_HEXOSE_PHOSPHATE_TRANSPORT": "The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY": "The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. [GOC:BHF, GOC:mah]", "GOBP_HETEROCHROMATIN_ORGANIZATION": "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. [GOC:mah]", "GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING": "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]", "GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE": "The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:mah]", "GOBP_HINDBRAIN_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_HINDBRAIN_DEVELOPMENT": "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). [PMID:4975589, PMID:4992177]", "GOBP_HINDBRAIN_RADIAL_GLIA_GUIDED_CELL_MIGRATION": "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]", "GOBP_HINDBRAIN_TANGENTIAL_CELL_MIGRATION": "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_HINDBRAIN_MORPHOGENESIS": "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_HINDGUT_DEVELOPMENT": "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. [GOC:dph]", "GOBP_HIPPOCAMPAL_NEURON_APOPTOTIC_PROCESS": "Any apoptotic process that occurs in a hippocampal neuron. [GOC:sl, PMID:18940801]", "GOBP_HINDLIMB_MORPHOGENESIS": "The process in which the anatomical structures of the hindlimb are generated and organized. [GOC:go_curators]", "GOBP_HISTAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:jl, ISBN:0395825172]", "GOBP_HIPPO_SIGNALING": "An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation. [PMID:17318211, PMID:18328423, PMID:36347846]", "GOBP_HIPPOCAMPUS_DEVELOPMENT": "The progression of the hippocampus over time from its initial formation until its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421]", "GOBP_HISTAMINE_SECRETION": "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems. [GOC:mah, ISBN:0198506732, ISBN:0781735149]", "GOBP_HISTAMINE_TRANSPORT": "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]", "GOBP_HISTIDINE_METABOLIC_PROCESS": "", "GOBP_HISTONE_MRNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving an mRNA encoding a histone. [GOC:krc, GOC:mah, PMID:17855393]", "GOBP_HISTONE_MRNA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393]", "GOBP_HIS_PURKINJE_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. [GOC:mtg_heart]", "GOBP_HOMOCYSTEINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. [ISBN:0198506732]", "GOBP_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE": "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. [GOC:isa_complete]", "GOBP_HOMOLOGOUS_CHROMOSOME_PAIRING_AT_MEIOSIS": "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]", "GOBP_HOMEOSTASIS_OF_NUMBER_OF_CELLS": "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. [GOC:isa_complete]", "GOBP_HOMOLOGOUS_CHROMOSOME_SEGREGATION": "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. [GOC:ai, ISBN:0815316194]", "GOBP_HOMOSERINE_METABOLIC_PROCESS": "", "GOBP_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES": "", "GOBP_HOMEOSTATIC_PROCESS": "Any biological process involved in the maintenance of an internal steady state. [GOC:jl, ISBN:0395825172]", "GOBP_HOMOTYPIC_CELL_CELL_ADHESION": "The attachment of a cell to a second cell of the identical type via adhesion molecules. [GOC:add]", "GOBP_HOMOLOGOUS_RECOMBINATION": "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules. [GOC:mah, PMID:11139492, PMID:17304215]", "GOBP_HORMONE_MEDIATED_APOPTOTIC_SIGNALING_PATHWAY": "The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered. [GOC:bf, GOC:mtg_apoptosis]", "GOBP_HORMONE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl]", "GOBP_HORMONE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl]", "GOBP_HORMONE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl]", "GOBP_HOST_MEDIATED_REGULATION_OF_INTESTINAL_MICROBIOTA_COMPOSITION": "", "GOBP_HORMONE_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals mediated by the detection of a hormone. [GOC:sm]", "GOBP_HRI_MEDIATED_SIGNALING": "A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. [PMID:27629041]", "GOBP_HORMONE_TRANSPORT": "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:tb]", "GOBP_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN": "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_HYALOID_VASCULAR_PLEXUS_REGRESSION": "The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression. [GOC:hjd, PMID:18841878]", "GOBP_HYALURONAN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine. [PMID:33171800, PMID:35536932]", "GOBP_HYALURONAN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine. [PMID:33171800, PMID:35536932]", "GOBP_HUMORAL_IMMUNE_RESPONSE": "An immune response mediated through a body fluid. [GOC:hb, ISBN:0198506732]", "GOBP_HYDROCARBON_METABOLIC_PROCESS": "The chemical reactions and pathways involving a hydrocarbon, a compound consisting of carbon and hydrogen only. [GOC:krc, Wikipedia:Hydrocarbon]", "GOBP_HYDROGEN_PEROXIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:ai]", "GOBP_HYALURONAN_METABOLIC_PROCESS": "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine. [PMID:33171800, PMID:35536932]", "GOBP_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). [GOC:jl]", "GOBP_HYDROGEN_SULFIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving hydrogen sulfide, H2S. [GOC:mah]", "GOBP_HYPEROSMOTIC_RESPONSE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. [GOC:jl, PMID:12142009]", "GOBP_HYDROGEN_PEROXIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:jl, PMID:21734470]", "GOBP_HYPEROSMOTIC_SALINITY_RESPONSE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:jl]", "GOBP_HYPERSENSITIVITY": "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system. [GOC:jal, ISBN:0781735149]", "GOBP_HYPOTHALAMUS_CELL_DIFFERENTIATION": "The differentiation of cells that will contribute to the structure and function of the hypothalamus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators]", "GOBP_HYPOTHALAMUS_CELL_MIGRATION": "The directed movement of a cell into the hypothalamus region of the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_HYPOTHALAMUS_DEVELOPMENT": "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_HYPOTHALAMUS_GONADOTROPHIN_RELEASING_HORMONE_NEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_HYPOTONIC_RESPONSE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. [GOC:jl, PMID:12598593]", "GOBP_HYPOXIA_INDUCIBLE_FACTOR_1ALPHA_SIGNALING_PATHWAY": "The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. [GOC:bf, GOC:jc, PMID:16887934, PMID:26579469]", "GOBP_ICOSANOID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of icosanoid. [GOC:pr, GOC:TermGenie]", "GOBP_ICOSANOID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. [ISBN:0198506732]", "GOBP_IMMATURE_T_CELL_PROLIFERATION": "The expansion of an immature T cell population by cell division. [GOC:add, ISBN:0781735149]", "GOBP_IMMATURE_B_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of an immature B cell. [GOC:jal, ISBN:0781735149, PMID:16551251]", "GOBP_ICOSANOID_SECRETION": "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue. [GOC:mah]", "GOBP_ICOSANOID_TRANSPORT": "The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. [GOC:mah]", "GOBP_ICOSANOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. [GOC:ma]", "GOBP_IMMUNE_COMPLEX_CLEARANCE": "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. [GO_REF:0000022, GOC:add, ISBN:068340007X]", "GOBP_IMMUNE_RESPONSE_INHIBITING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_IMMUNE_RESPONSE_INHIBITING_SIGNAL_TRANSDUCTION": "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_IMMUNE_EFFECTOR_PROCESS": "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_PHAGOCYTOSIS": "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. [GO_REF:0000022, GOC:add, GOC:bf, ISBN:0781735149]", "GOBP_IMMUNE_RESPONSE_TO_TUMOR_CELL": "An immune system process that functions in the response of an organism to a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]", "GOBP_IMMUNOGLOBULIN_V_D_J_RECOMBINATION": "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined. [GOC:add, ISBN:0781735149]", "GOBP_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]", "GOBP_IMMUNOGLOBULIN_PRODUCTION": "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]", "GOBP_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE": "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149, PMID:9185563]", "GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY": "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]", "GOBP_IMMUNOLOGICAL_MEMORY_FORMATION_PROCESS": "Any immunological memory process that can contribute to the formation of immunological memory. [GOC:add, PMID:26086132, PMID:26831526]", "GOBP_IMMUNE_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. [GOC:add, GOC:dph]", "GOBP_IMMUNOLOGICAL_MEMORY_PROCESS": "Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory. [GOC:add, PMID:26086132, PMID:26831526]", "GOBP_IMMUNOLOGICAL_SYNAPSE_FORMATION": "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376330]", "GOBP_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]", "GOBP_IMPORT_INTO_THE_MITOCHONDRION": "The directed movement of substances from the cytosol into the mitochondrion. [GOC:ew]", "GOBP_IMP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. [ISBN:0198506732]", "GOBP_IMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving IMP, inosine monophosphate. [GOC:go_curators]", "GOBP_IMPORT_INTO_NUCLEUS": "The directed movement of substances into the nucleus. [GOC:ai]", "GOBP_IMP_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate. [ISBN:0198506732]", "GOBP_IMP_SALVAGE": "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. [GOC:mah]", "GOBP_INCLUSION_BODY_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an inclusion body. [GOC:BHF, GOC:mah]", "GOBP_INDOLALKYLAMINE_METABOLIC_PROCESS": "", "GOBP_IMPORT_INTO_CELL": "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. [GOC:dos]", "GOBP_INDOLE_CONTAINING_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. [GOC:jl]", "GOBP_INDOLE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. [GOC:jl]", "GOBP_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. [GOC:jl, GOC:mah]", "GOBP_INDUCTION_OF_POSITIVE_CHEMOTAXIS": "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]", "GOBP_INDUCTION_OF_BACTERIAL_AGGLUTINATION": "Any process in which infecting bacteria are clumped together by a host organism. [GOC:jl]", "GOBP_INFLAMMATORY_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. [GOC:jl, GOC:mtg_apoptosis]", "GOBP_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY": "An intracellular signal transduction pathway that starts with a ligand binding to a pattern recognition receptor (PRR), assembly of the inflammasome complex, leading to the activation of CASP1 and inducing an inflammatory response. In some cases, inflammasome-mediated signal transduction can lead to programmed cell death, such as pyroptosis. [PMID:35883561]", "GOBP_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS": "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. [GOC:add, ISBN:0781735149]", "GOBP_INHIBITORY_POSTSYNAPTIC_POTENTIAL": "A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. [GOC:dph, GOC:ef]", "GOBP_INFLAMMATORY_RESPONSE_TO_WOUNDING": "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. [GOC:add]", "GOBP_INHIBITORY_SYNAPSE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie]", "GOBP_INHIBITION_OF_NEUROEPITHELIAL_CELL_DIFFERENTIATION": "", "GOBP_INNERVATION": "The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. [GOC:dph, GOC:sart]", "GOBP_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a cell surface receptor that leads to the activation of an innate immune response. [GOC:add, ISBN:0781735149, PMID:15199967]", "GOBP_INNATE_IMMUNE_RESPONSE_IN_MUCOSA": "Any process of the innate immune response that takes place in the mucosal tissues. [GOC:add, PMID:10719665, PMID:15971105]", "GOBP_INNER_CELL_MASS_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "GOBP_INFLAMMATORY_RESPONSE": "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]", "GOBP_INNER_CELL_MASS_CELL_PROLIFERATION": "The proliferation of cells in the inner cell mass. [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]", "GOBP_INNER_DYNEIN_ARM_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. [GOC:BHF, GOC:vk, PMID:19944400]", "GOBP_INNATE_IMMUNE_RESPONSE": "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]", "GOBP_INNER_EAR_MORPHOGENESIS": "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. [GOC:jl, ISBN:0192801023]", "GOBP_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph]", "GOBP_INNER_EAR_RECEPTOR_CELL_FATE_COMMITMENT": "The process in which a cell becomes committed to become an inner ear receptor cell. [GOC:dph]", "GOBP_INNER_EAR_RECEPTOR_CELL_STEREOCILIUM_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. [GOC:dph]", "GOBP_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORT": "", "GOBP_INOSINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. [GOC:go_curators]", "GOBP_INOSITOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. [ISBN:0198547684]", "GOBP_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]", "GOBP_INORGANIC_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]", "GOBP_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:mah]", "GOBP_INORGANIC_ANION_TRANSPORT": "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. [GOC:krc]", "GOBP_INOSITOL_PHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:jl]", "GOBP_INOSITOL_TRISPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. [GOC:mah]", "GOBP_INORGANIC_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell. [GOC:dos]", "GOBP_INOSITOL_TRISPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. [GOC:mah]", "GOBP_INSULIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving insulin. [GOC:TermGenie]", "GOBP_INSEMINATION": "The introduction of semen or sperm into the genital tract of a female. [ISBN:0582227089]", "GOBP_INSULIN_PROCESSING": "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges. [ISBN:0198506732]", "GOBP_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]", "GOBP_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS": "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. [GOC:bf, GOC:yaf, PMID:8492079]", "GOBP_INSULIN_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. [GOC:ceb]", "GOBP_INTEGRIN_ACTIVATION": "The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands. [GOC:add, PMID:12213832, PMID:14754902]", "GOBP_INTEGRIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules. [GOC:go_curators, ISBN:0198506732]", "GOBP_INSULIN_SECRETION": "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. [GOC:mah, ISBN:0198506732]", "GOBP_INTEGRATED_STRESS_RESPONSE_SIGNALING": "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. [PMID:27629041]", "GOBP_INTERCELLULAR_TRANSPORT": "The movement of substances between cells. [GOC:dhl]", "GOBP_INTERFERON_ALPHA_PRODUCTION": "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:15546383]", "GOBP_INTEGRIN_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]", "GOBP_INTERFERON_BETA_PRODUCTION": "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, PMID:15546383]", "GOBP_INTERLEUKIN_10_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [PMID:11244051]", "GOBP_INTERKINETIC_NUCLEAR_MIGRATION": "", "GOBP_INTERLEUKIN_12_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling]", "GOBP_INTERFERON_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by type II interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type II interferon is also known as interferon-gamma. [GOC:add, GOC:dph, GOC:signaling, PMID:32464097]", "GOBP_INTERLEUKIN_11_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of interleukin-11 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]", "GOBP_INTERLEUKIN_10_PRODUCTION": "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_13_PRODUCTION": "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_17_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ic, PMID:21602493]", "GOBP_INTERLEUKIN_17A_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-17A binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, GOC:signaling]", "GOBP_INTERLEUKIN_12_PRODUCTION": "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_18_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:BHF, GOC:signaling]", "GOBP_INTERLEUKIN_17_PRODUCTION": "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah, GOC:rv, Wikipedia:Interleukin_17]", "GOBP_INTERLEUKIN_1_ALPHA_PRODUCTION": "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_18_PRODUCTION": "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, GOC:signaling]", "GOBP_INTERLEUKIN_21_PRODUCTION": "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_1_PRODUCTION": "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_23_PRODUCTION": "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_27_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-27 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]", "GOBP_INTERLEUKIN_2_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]", "GOBP_INTERLEUKIN_33_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-33 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, GOC:signaling]", "GOBP_INTERLEUKIN_3_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling]", "GOBP_INTERLEUKIN_4_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-4 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling]", "GOBP_INTERLEUKIN_2_PRODUCTION": "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_5_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]", "GOBP_INTERLEUKIN_4_PRODUCTION": "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_5_PRODUCTION": "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERLEUKIN_6_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:add, GOC:BHF, GOC:mah, GOC:signaling]", "GOBP_INTERLEUKIN_8_PRODUCTION": "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERMEDIATE_FILAMENT_BUNDLE_ASSEMBLY": "The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs. [ISBN:0716731363]", "GOBP_INTERLEUKIN_6_PRODUCTION": "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_INTERMEDIATE_FILAMENT_BASED_PROCESS": "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. [GOC:ai]", "GOBP_INTERMEDIATE_FILAMENT_ORGANIZATION": "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. [GOC:ai]", "GOBP_INTERNAL_PROTEIN_AMINO_ACID_ACETYLATION": "The addition of an acetyl group to a non-terminal amino acid in a protein. [GOC:mah]", "GOBP_INTERMEMBRANE_LIPID_TRANSFER": "The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]", "GOBP_INTERNAL_PEPTIDYL_LYSINE_ACETYLATION": "", "GOBP_INTERNEURON_MIGRATION": "The orderly movement of an interneuron from one site to another. [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]", "GOBP_INTERNEURON_MIGRATION_FROM_THE_SUBPALLIUM_TO_THE_CORTEX": "The directed movement of interneurons from the subpallium to the cortex during forebrain development. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_INTESTINAL_CHOLESTEROL_ABSORPTION": "Uptake of cholesterol into the blood by absorption from the small intestine. [GOC:mah]", "GOBP_INTERSTRAND_CROSS_LINK_REPAIR": "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. [GOC:vw, PMID:16464006, PMID:22064477]", "GOBP_INTESTINAL_ABSORPTION": "A process in which nutrients are taken up from the contents of the intestine. [GOC:ai, GOC:dph]", "GOBP_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. [GOC:dph]", "GOBP_INTESTINAL_EPITHELIAL_STRUCTURE_MAINTENANCE": "A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_INTESTINAL_HEXOSE_ABSORPTION": "Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine. [GOC:hjd]", "GOBP_INTESTINAL_EPITHELIAL_CELL_MATURATION": "", "GOBP_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. [GOC:dph]", "GOBP_INTESTINAL_LIPID_ABSORPTION": "A process in which lipids are taken up from the contents of the intestine. [GOC:dos, GOC:sl, PMID:18768481]", "GOBP_INTESTINAL_STEM_CELL_HOMEOSTASIS": "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells. [GOC:nhn, PMID:22042863, PMID:22608824]", "GOBP_INTESTINE_SMOOTH_MUSCLE_CONTRACTION": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. [GOC:mtg_muscle, MA:0001539, MSH:D007422]", "GOBP_INTRACELLULAR_AMINO_ACID_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of amino acids within a cell. [PMID:19955263]", "GOBP_INTRACELLULAR_DISTRIBUTION_OF_MITOCHONDRIA": "Any process that establishes the spatial arrangement of mitochondria within the cell. [GOC:jid]", "GOBP_INTRACELLULAR_CORTICOSTEROID_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_INTRACELLULAR_GLUTAMATE_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of glutamate within a cell. [GOC:tb]", "GOBP_INTRACELLULAR_IRON_ION_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. [GOC:ai, GOC:mah]", "GOBP_INTRACELLULAR_MAGNESIUM_ION_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of magnesium ions within a cell. [GOC:dph, GOC:tb]", "GOBP_INTRACELLULAR_GLUCOSE_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_INTRACELLULAR_LIPID_TRANSPORT": "The directed movement of lipids within cells. [GOC:mah]", "GOBP_INTRACELLULAR_MRNA_LOCALIZATION": "Any process in which mRNA is transported to, or maintained in, a specific location within the cell. [GOC:ai]", "GOBP_INTRACELLULAR_MONOATOMIC_ANION_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of monoatomic anions within a cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom. [GOC:ceb, GOC:mah]", "GOBP_INTRACELLULAR_PHOSPHATE_ION_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell. [GOC:mah]", "GOBP_INTRACELLULAR_OXYGEN_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell. [GOC:rph]", "GOBP_INTRACELLULAR_PH_ELEVATION": "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai]", "GOBP_INTRACELLULAR_POTASSIUM_ION_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah]", "GOBP_INTRACELLULAR_PH_REDUCTION": "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai]", "GOBP_INTRACELLULAR_PROTEIN_TRANSMEMBRANE_TRANSPORT": "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. [GOC:isa_complete]", "GOBP_INTRACELLULAR_SIGNALING_CASSETTE": "", "GOBP_INTRACELLULAR_SODIUM_ION_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah]", "GOBP_INTRACELLULAR_SPHINGOLIPID_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of sphingolipids within a cell. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_INTRACELLULAR_STEROL_TRANSPORT": "The directed movement of sterols within cells. [GOC:mah]", "GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a receptor located within a cell. [GOC:bf, GOC:mah]", "GOBP_INTRACELLULAR_TRANSPORT_OF_VIRUS": "", "GOBP_INTRACELLULAR_TRIGLYCERIDE_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell. [GOC:BHF]", "GOBP_INTRACELLULAR_PROTEIN_TRANSPORT": "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. [GOC:mah]", "GOBP_INTRACELLULAR_WATER_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of water within a cell. [GOC:dph, GOC:tb]", "GOBP_INTRACILIARY_ANTEROGRADE_TRANSPORT": "The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins. [GOC:BHF, GOC:cilia, PMID:17895364]", "GOBP_INTRACELLULAR_ZINC_ION_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell. [GOC:ai, GOC:mah]", "GOBP_INTRACELLULAR_TRANSPORT": "The directed movement of substances within a cell. [GOC:ai]", "GOBP_INTRACILIARY_RETROGRADE_TRANSPORT": "The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins. [GOC:BHF, GOC:cilia]", "GOBP_INTRACILIARY_TRANSPORT": "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]", "GOBP_INTRACILIARY_TRANSPORT_INVOLVED_IN_CILIUM_ASSEMBLY": "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. [GOC:bf, GOC:cilia]", "GOBP_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT": "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). [ISBN:0716731363]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. [GOC:mah, GOC:mtg_apoptosis]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_HYDROGEN_PEROXIDE": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2). [GOC:bf, GOC:PARL]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_HYPOXIA": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OSMOTIC_STRESS": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:11454444, PMID:16483738]", "GOBP_IODIDE_TRANSPORT": "The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OXIDATIVE_STRESS": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. [GOC:ai, GOC:mtg_apoptosis]", "GOBP_IN_UTERO_EMBRYONIC_DEVELOPMENT": "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]", "GOBP_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_ION_CHANNEL_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_IP_10_PRODUCTION": "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]", "GOBP_IRIS_MORPHOGENESIS": "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. [GOC:dph]", "GOBP_IRON_COORDINATION_ENTITY_TRANSPORT": "The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:pr, GOC:TermGenie]", "GOBP_IRES_DEPENDENT_VIRAL_TRANSLATIONAL_INITIATION": "Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation. [GOC:bf, GOC:jl, PMID:19632368, VZ:867]", "GOBP_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE": "The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. [GOC:bf, GOC:PARL, PMID:22013210]", "GOBP_IRON_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:mah, PMID:8321236]", "GOBP_IRON_IMPORT_INTO_CELL": "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. [PMID:18622392, PMID:23192658, Wikipedia:Human_iron_metabolism]", "GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT": "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah, PMID:11390404]", "GOBP_ISG15_PROTEIN_CONJUGATION": "The covalent addition to a protein of ISG15, a ubiquitin-like protein. [GOC:mah]", "GOBP_IRON_ION_TRANSPORT": "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_ISOCITRATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. [ISBN:0198506732]", "GOBP_ISOLEUCINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. [GOC:ai]", "GOBP_ISOLEUCINE_TRANSPORT": "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_ISOPENTENYL_DIPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids. [GOC:jl, ISBN:0198506732]", "GOBP_ISOPRENOID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198506732]", "GOBP_ISOPRENOID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198506732]", "GOBP_ISOPRENOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198547684]", "GOBP_ISOTYPE_SWITCHING_TO_IGA_ISOTYPES": "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus. [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]", "GOBP_ISOPRENOID_TRANSPORT": "", "GOBP_ISOTYPE_SWITCHING_TO_IGG_ISOTYPES": "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus. [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]", "GOBP_I_KAPPAB_PHOSPHORYLATION": "", "GOBP_KERATAN_SULFATE_METABOLIC_PROCESS": "", "GOBP_KERATINOCYTE_APOPTOTIC_PROCESS": "Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. [CL:0000312, GOC:jc, GOC:mtg_apoptosis, PMID:10201527]", "GOBP_KERATINOCYTE_DEVELOPMENT": "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure. [GOC:dph]", "GOBP_JNK_CASCADE": "A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. [PMID:11790549, PMID:20811974, PMID:23125017]", "GOBP_KERATINIZATION": "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]", "GOBP_KERATINOCYTE_MIGRATION": "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another. [ISBN:0721662544]", "GOBP_KERATINOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]", "GOBP_KERATINOCYTE_PROLIFERATION": "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. [CL:0000311]", "GOBP_KETONE_BODY_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA. [ISBN:0198506732]", "GOBP_KETONE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. [GOC:go_curators]", "GOBP_KETONE_BODY_METABOLIC_PROCESS": "The chemical reactions and pathways involving ketone body. [GOC:pr, GOC:TermGenie]", "GOBP_KETONE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. [GOC:go_curators]", "GOBP_KIDNEY_MESENCHYME_DEVELOPMENT": "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. [GOC:mtg_kidney_jan10]", "GOBP_KILLING_BY_HOST_OF_SYMBIONT_CELLS": "", "GOBP_KIDNEY_EPITHELIUM_DEVELOPMENT": "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:mtg_kidney_jan10]", "GOBP_KIDNEY_MORPHOGENESIS": "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10]", "GOBP_KYNURENINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine. [CHEBI:28683, GOC:mah, GOC:rph]", "GOBP_KINETOCHORE_ASSEMBLY": "", "GOBP_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT": "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. [GOC:dph]", "GOBP_KINETOCHORE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]", "GOBP_LABYRINTHINE_LAYER_MORPHOGENESIS": "", "GOBP_LACTATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving lactate, the anion of lactic acid. [ISBN:0198547684]", "GOBP_LACRIMAL_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. [GOC:ln]", "GOBP_LACTATE_TRANSMEMBRANE_TRANSPORT": "The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. [GOC:mcc, ISBN:0198506732]", "GOBP_LABYRINTHINE_LAYER_DEVELOPMENT": "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. [GOC:dph]", "GOBP_LACTONE_METABOLIC_PROCESS": "The chemical reactions and pathways involving lactone. [GOC:TermGenie]", "GOBP_LAMELLIPODIUM_MORPHOGENESIS": "A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized. [GOC:BHF, GOC:mah]", "GOBP_LACTATION": "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. [ISBN:0198506732]", "GOBP_LAMELLIPODIUM_ASSEMBLY": "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:mah, ISBN:0815316194]", "GOBP_LAMELLIPODIUM_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. [GOC:als, PMID:16054028]", "GOBP_LATERAL_MESODERM_MORPHOGENESIS": "The process in which the anatomical structures of the lateral mesoderm are generated and organized. [GOC:go_curators]", "GOBP_LATERAL_SPROUTING_FROM_AN_EPITHELIUM": "The process in which a branch forms along the side of an epithelium. [GOC:dph]", "GOBP_LATERAL_MESODERM_DEVELOPMENT": "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. [GOC:go_curators]", "GOBP_LATE_ENDOSOME_TO_GOLGI_TRANSPORT": "The directed movement of substances from late endosomes to the Golgi. [GOC:rb]", "GOBP_LATERAL_VENTRICLE_DEVELOPMENT": "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_LATE_ENDOSOME_TO_LYSOSOME_TRANSPORT": "The directed movement of substances from late endosome to lysosome. [GO_REF:0000076, GOC:TermGenie, PMID:23949442]", "GOBP_LAYER_FORMATION_IN_CEREBRAL_CORTEX": "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_LATE_ENDOSOME_TO_VACUOLE_TRANSPORT_VIA_MULTIVESICULAR_BODY_SORTING_PATHWAY": "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. [GOC:mah, PMID:12461556, PMID:16689637]", "GOBP_LATE_ENDOSOME_TO_VACUOLE_TRANSPORT": "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. [PMID:11872141]", "GOBP_LEARNED_VOCALIZATION_BEHAVIOR_OR_VOCAL_LEARNING": "Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned. [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]", "GOBP_LEFT_RIGHT_AXIS_SPECIFICATION": "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). [GOC:dph, GOC:gvg, GOC:mah]", "GOBP_LENS_FIBER_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. [GOC:mah, PMID:7693735]", "GOBP_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE": "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. [GOC:dph, ISBN:0582064333]", "GOBP_LENS_FIBER_CELL_MORPHOGENESIS": "The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. [GOC:mah, PMID:7693735]", "GOBP_LEARNING": "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. [ISBN:0582227089, ISBN:0721662544]", "GOBP_LENS_FIBER_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. [GOC:mah, PMID:7693735]", "GOBP_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE": "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. [GOC:dph, GOC:mtg_sensu]", "GOBP_LEPTIN_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. [GOC:mah, GOC:signaling, GOC:yaf]", "GOBP_LEUKOCYTE_ADHESION_TO_ARTERIAL_ENDOTHELIAL_CELL": "The attachment of a leukocyte to an arterial endothelial cell via adhesion molecules. [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22267480]", "GOBP_LEUKOCYTE_ACTIVATION_INVOLVED_IN_INFLAMMATORY_RESPONSE": "", "GOBP_LEUKOCYTE_AGGREGATION": "The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules. [GOC:sl, PMID:12972508]", "GOBP_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL": "The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:23897866]", "GOBP_LEUKOCYTE_CHEMOTAXIS_INVOLVED_IN_INFLAMMATORY_RESPONSE": "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response. [GOC:add, ISBN:0781735149]", "GOBP_LEUKOCYTE_APOPTOTIC_PROCESS": "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]", "GOBP_LEUKOCYTE_CHEMOTAXIS": "The movement of a leukocyte in response to an external stimulus. [GOC:add, GOC:jl]", "GOBP_LEUKOCYTE_DEGRANULATION": "The regulated exocytosis of secretory granules by a leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_LEUKOCYTE_HOMEOSTASIS": "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, ISBN:0781735149]", "GOBP_LEUKOCYTE_MEDIATED_CYTOTOXICITY": "The directed killing of a target cell by a leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:11911826]", "GOBP_LEUKOCYTE_CELL_CELL_ADHESION": "The attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators]", "GOBP_LEUKOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. [CL:0000738, GOC:add, PMID:16551264]", "GOBP_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE": "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]", "GOBP_LEUKOCYTE_MIGRATION": "The movement of a leukocyte within or between different tissues and organs of the body. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]", "GOBP_LEUKOTRIENE_B4_METABOLIC_PROCESS": "The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. [GOC:bf]", "GOBP_LEUKOCYTE_TETHERING_OR_ROLLING": "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). [GOC:bf, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538, Wikipedia:Leukocyte_extravasation]", "GOBP_LEUKOCYTE_MEDIATED_IMMUNITY": "Any process involved in the carrying out of an immune response by a leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_LEUKOTRIENE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:go_curators]", "GOBP_LEUKOCYTE_PROLIFERATION": "The expansion of a leukocyte population by cell division. [GOC:add]", "GOBP_LEUKOTRIENE_D4_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of leukotriene D4. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00880]", "GOBP_LEUKOTRIENE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:yaf]", "GOBP_LEUKOTRIENE_D4_METABOLIC_PROCESS": "", "GOBP_LEUKOTRIENE_METABOLIC_PROCESS": "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:ma]", "GOBP_LEUKOTRIENE_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:dph, PMID:21771892]", "GOBP_LEYDIG_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. [GOC:ln, PMID:12050120]", "GOBP_LEUKOTRIENE_TRANSPORT": "The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups. [GOC:mah]", "GOBP_LIGAND_GATED_ION_CHANNEL_SIGNALING_PATHWAY": "The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription. [GOC:bhm, PMID:25869137]", "GOBP_LIMBIC_SYSTEM_DEVELOPMENT": "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]", "GOBP_LIMB_JOINT_MORPHOGENESIS": "The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner. [GOC:bf]", "GOBP_LIMB_BUD_FORMATION": "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable. [GOC:dgh, GOC:dph]", "GOBP_LINOLEIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. [Wikipedia:Linoleic_Acid]", "GOBP_LIPID_DIGESTION": "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. [GOC:go_curators]", "GOBP_LIPID_DROPLET_FORMATION": "A process that results in the assembly, arrangement of constituent parts of a lipid droplet. [PMID:28011631]", "GOBP_LIPID_DROPLET_DISASSEMBLY": "The disaggregation of a lipid particle into its constituent components. [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]", "GOBP_LIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]", "GOBP_LIPID_DROPLET_FUSION": "The process by which a single lipid droplet is created from the fusion of two or more lipid droplets. [PMID:34508658, PMID:36477540]", "GOBP_LIPID_GLYCOSYLATION": "", "GOBP_LIPID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]", "GOBP_LIPID_DROPLET_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]", "GOBP_LIPID_EXPORT_FROM_CELL": "The directed movement of a lipid from a cell, into the extracellular region. [GOC:pg]", "GOBP_LIPID_HYDROXYLATION": "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid. [GOC:hjd, PMID:15658937]", "GOBP_LIPID_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl]", "GOBP_LIPID_IMPORT_INTO_CELL": "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. [GOC:pg]", "GOBP_LIPID_PHOSPHORYLATION": "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. [GOC:bf, ISBN:0198506732]", "GOBP_LIPID_LOCALIZATION": "Any process in which a lipid is transported to, or maintained in, a specific location. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_LIPID_STORAGE": "", "GOBP_LIPID_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER": "The directed movement of lipid molecules passing through the blood-brain barrier. [GOC:sjp, PMID:24345162]", "GOBP_LIPID_OXIDATION": "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. [GOC:BHF, GOC:mah]", "GOBP_LIPID_MODIFICATION": "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. [GOC:mah]", "GOBP_LIPOPHAGY": "The selective degradation of lipid droplets by macroautophagy. [GOC:autophagy, PMID:23708524, PMID:26076903]", "GOBP_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. [GOC:mah, GOC:signaling, PMID:15379975]", "GOBP_LIPOPROTEIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. [ISBN:0198506732]", "GOBP_LIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]", "GOBP_LIPOPROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. [ISBN:0198506732]", "GOBP_LIPOPROTEIN_LOCALIZATION": "Any process in which a lipoprotein is transported to, or maintained in, a specific location. [GOC:jl]", "GOBP_LIPOXIN_METABOLIC_PROCESS": "", "GOBP_LIPOPROTEIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. [ISBN:0198506732]", "GOBP_LIVER_MORPHOGENESIS": "The process in which the anatomical structures of the liver are generated and organized. [GOC:mah]", "GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving liposaccharide. [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:9452964]", "GOBP_LIPOXYGENASE_PATHWAY": "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. [GOC:mah, PMID:17163881]", "GOBP_LNCRNA_MEDIATED_POST_TRANSCRIPTIONAL_GENE_SILENCING": "A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs or mRNAs. [PMID:34454184, PMID:35055152]", "GOBP_LIVER_REGENERATION": "The regrowth of lost or destroyed liver. [GOC:gap, PMID:19447520]", "GOBP_LOBAR_BRONCHUS_EPITHELIUM_DEVELOPMENT": "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus. [GOC:dph, GOC:mtg_lung]", "GOBP_LOBAR_BRONCHUS_DEVELOPMENT": "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi. [GOC:dph, GOC:mtg_lung]", "GOBP_LOCALIZATION_OF_CELL": "Any process in which a cell is transported to, and/or maintained in, a specific location. [GOC:ai]", "GOBP_LOCOMOTION_INVOLVED_IN_LOCOMOTORY_BEHAVIOR": "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. [GOC:mah]", "GOBP_LOCOMOTORY_EXPLORATION_BEHAVIOR": "The specific movement from place to place of an organism in response to a novel environment. [GOC:sart, PMID:17151232]", "GOBP_LONG_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [PMID:18390550]", "GOBP_LONG_CHAIN_FATTY_ACID_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ai]", "GOBP_LOCOMOTOR_RHYTHM": "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle. [GOC:go_curators]", "GOBP_LOCOMOTORY_BEHAVIOR": "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]", "GOBP_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [PMID:20043225]", "GOBP_LOCALIZATION_WITHIN_MEMBRANE": "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. [GOC:ai]", "GOBP_LOCOMOTION": "Self-propelled movement of a cell or organism from one location to another. [GOC:dgh]", "GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ajp]", "GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT": "The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ai]", "GOBP_LONG_CHAIN_FATTY_ACYL_COA_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [ISBN:0198506732]", "GOBP_LONG_CHAIN_FATTY_ACYL_COA_METABOLIC_PROCESS": "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [ISBN:0198506732]", "GOBP_LOOP_OF_HENLE_DEVELOPMENT": "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. [GOC:mtg_kidney_jan10]", "GOBP_LONG_TERM_MEMORY": "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]", "GOBP_LONG_TERM_SYNAPTIC_DEPRESSION": "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph]", "GOBP_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE": "The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:mah]", "GOBP_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING": "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]", "GOBP_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_PARTICLE_METABOLIC_PROCESS": "The chemical reactions and pathways involving low-density lipoprotein receptors. [GOC:vk]", "GOBP_LONG_TERM_SYNAPTIC_POTENTIATION": "A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph]", "GOBP_LUNG_ALVEOLUS_DEVELOPMENT": "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. [GOC:mtg_lung, PMID:9751757]", "GOBP_LUNG_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph, GOC:mtg_lung]", "GOBP_LUNG_ASSOCIATED_MESENCHYME_DEVELOPMENT": "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung. [GOC:dph, GOC:mtg_lung]", "GOBP_LUNG_GROWTH": "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. [GOC:dph]", "GOBP_LUNG_EPITHELIUM_DEVELOPMENT": "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. [GOC:dph, GOC:mtg_lung]", "GOBP_LUNG_LOBE_DEVELOPMENT": "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. [GOC:dph]", "GOBP_LUNG_SECRETORY_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. [GOC:dph]", "GOBP_LUNG_SACCULE_DEVELOPMENT": "The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells. [GOC:dph, GOC:mtg_lung]", "GOBP_LUNG_VASCULATURE_DEVELOPMENT": "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. [GOC:dph, GOC:mtg_lung]", "GOBP_LUNG_MORPHOGENESIS": "The process in which the anatomical structures of the lung are generated and organized. [GOC:dph]", "GOBP_LUTEINIZATION": "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "GOBP_LUTEOLYSIS": "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy. [PMID:10617764]", "GOBP_LUTEINIZING_HORMONE_SECRETION": "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. [ISBN:0198506732]", "GOBP_LYMPHANGIOGENESIS": "", "GOBP_LYMPHATIC_ENDOTHELIAL_CELL_DIFFERENTIATION": "The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_LYMPHOCYTE_AGGREGATION": "The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules. [GOC:sl]", "GOBP_LYMPHOCYTE_ANERGY": "Any process contributing to lymphocyte anergy, a state of functional inactivation. [GOC:add]", "GOBP_LYMPHOCYTE_APOPTOTIC_PROCESS": "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_LYMPHOCYTE_CHEMOTAXIS": "The directed movement of a lymphocyte in response to an external stimulus. [GOC:hjd, GOC:jid, PMID:12391252]", "GOBP_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_LYMPHOCYTE_COSTIMULATION": "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. [ISBN:0781735149]", "GOBP_LYMPHOCYTE_ACTIVATION": "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]", "GOBP_LYMPHOCYTE_HOMEOSTASIS": "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]", "GOBP_LYMPHOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. [CL:0000542, GOC:go_curators]", "GOBP_LYMPHOCYTE_MIGRATION_INTO_LYMPHOID_ORGANS": "The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. [GOC:BHF, GOC:pr, PMID:18379575]", "GOBP_LYMPHOCYTE_MEDIATED_IMMUNITY": "Any process involved in the carrying out of an immune response by a lymphocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. [GOC:add, PMID:16551251, PMID:16551264]", "GOBP_LYMPH_NODE_DEVELOPMENT": "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. [GOC:add, ISBN:068340007X, ISBN:0781735149]", "GOBP_LYMPHOCYTE_MIGRATION": "The movement of a lymphocyte within or between different tissues and organs of the body. [CL:0000542, GOC:BHF, GOC:mah]", "GOBP_LYMPH_VESSEL_DEVELOPMENT": "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. [GOC:dph, UBERON:0001473]", "GOBP_LYMPH_VESSEL_MORPHOGENESIS": "The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. [GOC:BHF, GOC:gr, PMID:18093989]", "GOBP_LYSOSOMAL_LUMEN_ACIDIFICATION": "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. [GOC:jid]", "GOBP_LYSINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. [GOC:go_curators]", "GOBP_LYSOSOMAL_PROTEIN_CATABOLIC_PROCESS": "", "GOBP_LYSOSOMAL_MEMBRANE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:yaf, PMID:20544854]", "GOBP_L_ALANINE_TRANSPORT": "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah]", "GOBP_LYTIC_VACUOLE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. [PMID:20729380]", "GOBP_L_ALANINE_TRANSMEMBRANE_TRANSPORT": "The directed movement of L-alanine across a membrane by means of some agent such as a transporter or a pore. [GO_REF:0000069, GOC:kmv, GOC:TermGenie]", "GOBP_LYSOSOMAL_TRANSPORT": "The directed movement of substances into, out of or within a lysosome. [GOC:ai]", "GOBP_L_AMINO_ACID_BIOSYNTHETIC_PROCESS": "", "GOBP_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT": "The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore. [GOC:kmv, GOC:TermGenie, PMID:14668347]", "GOBP_L_ARGININE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186]", "GOBP_L_AMINO_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of an L-amino acid. [GOC:edw]", "GOBP_L_AMINO_ACID_TRANSPORT": "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai, GOC:jsg, GOC:mah]", "GOBP_L_AMINO_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving an L-amino acid. [GOC:edw]", "GOBP_L_ASCORBIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:jl, ISBN:0198506732]", "GOBP_L_ASPARTATE_TRANSMEMBRANE_TRANSPORT": "The directed movement of L-aspartate across a membrane by means of some agent such as a transporter or a pore. [PMID:21307582]", "GOBP_L_ARGININE_TRANSMEMBRANE_TRANSPORT": "The directed movement of L-arginine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:18357653, PMID:22822152, PMID:8195186]", "GOBP_L_ASPARTATE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000069, PMID:7914198]", "GOBP_L_CYSTINE_TRANSPORT": "The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]", "GOBP_L_GLUTAMATE_IMPORT": "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle. [GOC:ai, GOC:jsg, GOC:mah]", "GOBP_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT": "The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. [PMID:21307582]", "GOBP_L_GLUTAMATE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]", "GOBP_L_GLUTAMINE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]", "GOBP_L_HISTIDINE_TRANSMEMBRANE_TRANSPORT": "The directed movement of L-histidine across a membrane. [PMID:21307582]", "GOBP_L_LEUCINE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of L-leucine from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000075, GOC:TermGenie, PMID:23895341]", "GOBP_L_KYNURENINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). [GOC:yaf]", "GOBP_L_LEUCINE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid. [GOC:ai]", "GOBP_L_LEUCINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving L-leucine, 2-amino-4-methylpentanoic acid. [GOC:ai]", "GOBP_L_LEUCINE_TRANSPORT": "The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_L_LYSINE_TRANSMEMBRANE_TRANSPORT": "", "GOBP_L_PHENYLALANINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. [GOC:jsg, GOC:mah]", "GOBP_L_PROLINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. [GOC:ecd]", "GOBP_L_METHIONINE_SALVAGE_FROM_METHYLTHIOADENOSINE": "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. [GOC:jl, MetaCyc:PWY-4361, PMID:19946895]", "GOBP_L_PROLINE_TRANSMEMBRANE_TRANSPORT": "The directed movement of L-proline across a membrane. [GO_REF:0000069, GOC:kmv, GOC:TermGenie]", "GOBP_L_SERINE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg]", "GOBP_L_SERINE_BIOSYNTHETIC_PROCESS": "", "GOBP_L_SERINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg]", "GOBP_MACROMOLECULE_DEACYLATION": "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. [GOC:dos]", "GOBP_MACROMOLECULE_DEPALMITOYLATION": "The removal of palymitoyl groups from a macromolecule. [GOC:dos]", "GOBP_MACROMOLECULE_METHYLATION": "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. [GOC:go_curators]", "GOBP_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_MACROPHAGE_APOPTOTIC_PROCESS": "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]", "GOBP_MACROPHAGE_ACTIVATION": "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]", "GOBP_MACROPHAGE_CHEMOTAXIS": "The movement of a macrophage in response to an external stimulus. [GOC:jid]", "GOBP_MACROAUTOPHAGY": "The autophagic process that proceeds via the formation of an autophagosome. [PMID:24366339]", "GOBP_MACROMOLECULE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah]", "GOBP_MACROPHAGE_COLONY_STIMULATING_FACTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor]", "GOBP_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION": "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:vk]", "GOBP_MACROPHAGE_CYTOKINE_PRODUCTION": "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]", "GOBP_MACROPHAGE_FUSION": "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell. [GOC:sl]", "GOBP_MACROPHAGE_INFLAMMATORY_PROTEIN_1_ALPHA_PRODUCTION": "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]", "GOBP_MACROPHAGE_DIFFERENTIATION": "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. [GOC:add, ISBN:0781735149]", "GOBP_MACROPHAGE_PROLIFERATION": "The expansion of a macrophage population by cell division. [GOC:dph, PMID:12614284, PMID:19466391]", "GOBP_MACROPINOCYTOSIS": "An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. [PMID:14732047]", "GOBP_MACROPHAGE_MIGRATION": "The orderly movement of a macrophage from one site to another. [GO_REF:0000091, GOC:TermGenie, PMID:25749876]", "GOBP_MAGNESIUM_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell. [GOC:dph, GOC:tb]", "GOBP_MAINTENANCE_OF_ANIMAL_ORGAN_IDENTITY": "The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tb]", "GOBP_MAGNESIUM_ION_TRANSPORT": "The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY": "Retaining the established polarization of a cell along its apical/basal axis. [GOC:bf]", "GOBP_MAINTENANCE_OF_BLOOD_BRAIN_BARRIER": "Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation. [GOC:aruk, GOC:bc, GOC:bf, GOC:sl, PMID:20080302, PMID:30280653]", "GOBP_MAINTENANCE_OF_CELL_POLARITY": "The maintenance of established anisotropic intracellular organization or cell growth patterns. [GOC:mah]", "GOBP_MAINTENANCE_OF_CENTROSOME_LOCATION": "Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_MAINTENANCE_OF_DNA_REPEAT_ELEMENTS": "Any process involved in sustaining the fidelity and copy number of DNA repeat elements. [GOC:jl]", "GOBP_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM": "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. [GOC:mah]", "GOBP_MAINTENANCE_OF_CELL_NUMBER": "Any process by which the numbers of cells of a particular type or in a tissue are maintained. [GOC:dos]", "GOBP_MAINTENANCE_OF_LENS_TRANSPARENCY": "A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina. [GOC:nhn, PMID:22095752]", "GOBP_MAINTENANCE_OF_LOCATION_IN_CELL": "", "GOBP_MAINTENANCE_OF_ORGANELLE_LOCATION": "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_MAINTENANCE_OF_POSTSYNAPTIC_SPECIALIZATION_STRUCTURE": "A process which maintains the organization and the arrangement of proteins in the presynaptic specialization. [GOC:dos]", "GOBP_MAINTENANCE_OF_LOCATION": "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_MAINTENANCE_OF_PRESYNAPTIC_ACTIVE_ZONE_STRUCTURE": "A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters. [GOC:curators, GOC:dph, GOC:pr]", "GOBP_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ENDOPLASMIC_RETICULUM": "Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. [GOC:bf, GOC:vw]", "GOBP_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE": "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. [GOC:mah]", "GOBP_MAINTENANCE_OF_PROTEIN_LOCATION_IN_EXTRACELLULAR_REGION": "Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere. [GOC:mah]", "GOBP_MAINTENANCE_OF_PROTEIN_LOCATION_IN_CELL": "", "GOBP_MAINTENANCE_OF_PROTEIN_LOCATION": "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. [GOC:bf]", "GOBP_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS": "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. [GOC:ai]", "GOBP_MAINTENANCE_OF_PROTEIN_LOCATION_IN_MITOCHONDRION": "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere. [GOC:mah]", "GOBP_MAINTENANCE_OF_SISTER_CHROMATID_COHESION": "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate. [GOC:mah, PMID:14623866]", "GOBP_MALATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. [ISBN:0198506732]", "GOBP_MAINTENANCE_OF_SYNAPSE_STRUCTURE": "A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. [GOC:dos, PMID:24449494, PMID:25611509]", "GOBP_MALE_MATING_BEHAVIOR": "The specific behavior of a male organism that is associated with reproduction. [GOC:dph, GOC:pr, GOC:tb]", "GOBP_MALE_GENITALIA_DEVELOPMENT": "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. [GOC:ems, ISBN:0140512888]", "GOBP_MALE_MEIOSIS_I": "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. [GOC:dph, GOC:mah]", "GOBP_MALE_SEX_DETERMINATION": "The specification of male sex of an individual organism. [GOC:mah]", "GOBP_MALONYL_COA_METABOLIC_PROCESS": "The chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A. [GOC:yaf, PMID:11902724, PMID:15726818, PMID:18981598]", "GOBP_MALE_MEIOTIC_NUCLEAR_DIVISION": "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. [GOC:dph, GOC:mah, GOC:vw]", "GOBP_MALE_GAMETE_GENERATION": "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. [GOC:dph, GOC:jid]", "GOBP_MALE_SEX_DIFFERENTIATION": "The establishment of the sex of a male organism by physical differentiation. [GOC:bf]", "GOBP_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT": "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. [GOC:dph]", "GOBP_MAMMARY_GLAND_BRANCHING_INVOLVED_IN_PREGNANCY": "The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy. [GOC:dph, PMID:19261859]", "GOBP_MAMMALIAN_OOGENESIS_STAGE": "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell. [GOC:isa_complete, GOC:mtg_sensu]", "GOBP_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. [GOC:dph]", "GOBP_MAMMARY_GLAND_DUCT_MORPHOGENESIS": "The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. [GOC:dph, PMID:17120154]", "GOBP_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION": "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:mah]", "GOBP_MAMMARY_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. [PMID:9576833]", "GOBP_MAMMARY_GLAND_FORMATION": "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme. [GOC:dph, PMID:16168142, PMID:17120154]", "GOBP_MAMMARY_GLAND_INVOLUTION": "The tissue remodeling that removes differentiated mammary epithelia during weaning. [GOC:dph, PMID:15282149]", "GOBP_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:yaf]", "GOBP_MAMMARY_GLAND_MORPHOGENESIS": "The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph]", "GOBP_MANCHETTE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a manchette. [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866]", "GOBP_MANGANESE_ION_TRANSPORT": "The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_MANNOSE_METABOLIC_PROCESS": "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. [ISBN:0198506732]", "GOBP_MANNOSYLATION": "", "GOBP_MARGINAL_ZONE_B_CELL_DIFFERENTIATION": "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). [GOC:jal, ISBN:0781735149]", "GOBP_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_MAST_CELL_ACTIVATION": "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. [GOC:mgi_curators, ISBN:0781735149]", "GOBP_MAST_CELL_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a mast cell. [GOC:mah]", "GOBP_MAST_CELL_CHEMOTAXIS": "", "GOBP_MAST_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. [GOC:dph, GOC:tb]", "GOBP_MAST_CELL_MIGRATION": "The movement of a mast cell within or between different tissues and organs of the body. [GOC:cvs, PMID:24152847]", "GOBP_MAST_CELL_PROLIFERATION": "", "GOBP_MATERNAL_PLACENTA_DEVELOPMENT": "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]", "GOBP_MAPK_CASCADE": "An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267]", "GOBP_MATERNAL_PROCESS_INVOLVED_IN_PARTURITION": "A reproductive process occurring in the mother that results in birth. [GOC:dph]", "GOBP_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY": "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. [GOC:dph]", "GOBP_MATING_BEHAVIOR": "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. [GOC:ai, GOC:dph]", "GOBP_MATURATION_OF_5_8S_RRNA": "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. [GOC:curators]", "GOBP_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA": "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. [GOC:curators, PMID:10690410]", "GOBP_MATURATION_OF_LSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA": "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. [GOC:curators]", "GOBP_MATURATION_OF_LSU_RRNA": "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. [GOC:curators]", "GOBP_MATURATION_OF_SSU_RRNA": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. [GOC:curators]", "GOBP_MATURE_B_CELL_DIFFERENTIATION": "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. [GOC:jal, ISBN:0781735149]", "GOBP_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA": "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. [GOC:curators]", "GOBP_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE": "", "GOBP_MDA_5_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines. [GOC:bf, PMID:19620789, PMID:33087405]", "GOBP_MATURE_CONVENTIONAL_DENDRITIC_CELL_DIFFERENTIATION": "The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells. [GOC:BHF, PMID:15845453]", "GOBP_MECHANORECEPTOR_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. [CL:0000199, GOC:jl]", "GOBP_MEDIUM_CHAIN_FATTY_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [Wikipedia:Fatty_acid_metabolism]", "GOBP_MEDIUM_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [Wikipedia:Fatty_acid_metabolism]", "GOBP_MECHANOSENSORY_BEHAVIOR": "Behavior that is dependent upon the sensation of a mechanical stimulus. [GOC:go_curators]", "GOBP_MEDIUM_CHAIN_FATTY_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [Wikipedia:Fatty_acid_metabolisms]", "GOBP_MEGAKARYOCYTE_DEVELOPMENT": "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. [CL:0000556, GOC:BHF, GOC:vk]", "GOBP_MEDIUM_CHAIN_FATTY_ACYL_COA_METABOLIC_PROCESS": "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [GOC:pm]", "GOBP_MEGAKARYOCYTE_DIFFERENTIATION": "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. [GOC:mah]", "GOBP_MEIOTIC_ATTACHMENT_OF_TELOMERE_TO_NUCLEAR_ENVELOPE": "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation. [GOC:jp, GOC:pr, GOC:vw, PMID:18818742]", "GOBP_MEIOSIS_I_CELL_CYCLE_PROCESS": "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs. [PMID:29385397]", "GOBP_MEIOTIC_CELL_CYCLE_CHECKPOINT_SIGNALING": "A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage. [GOC:mtg_cell_cycle]", "GOBP_MEIOTIC_CELL_CYCLE_PHASE_TRANSITION": "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase. [GOC:mtg_cell_cycle]", "GOBP_MEIOTIC_CELL_CYCLE_PROCESS_INVOLVED_IN_OOCYTE_MATURATION": "Any meiotic cell cycle process that is involved in oocyte maturation. [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395]", "GOBP_MEIOTIC_CHROMOSOME_CONDENSATION": "Compaction of chromatin structure prior to meiosis in eukaryotic cells. [PMID:10072401]", "GOBP_MEIOTIC_CELL_CYCLE_PROCESS": "A process that is part of the meiotic cell cycle. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_MEIOTIC_CELL_CYCLE": "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. [GOC:ai]", "GOBP_MEIOTIC_CHROMOSOME_SEGREGATION": "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. [GOC:ai, GOC:mah]", "GOBP_MEIOTIC_CYTOKINESIS": "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells. [GOC:mtg_cell_cycle]", "GOBP_MEIOTIC_CHROMOSOME_SEPARATION": "The process in which chromosomes are physically detached from each other during meiosis. [GOC:ai]", "GOBP_MEIOTIC_DNA_DOUBLE_STRAND_BREAK_FORMATION": "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. [GOC:elh, GOC:jl, PMID:11529427]", "GOBP_MEIOTIC_METAPHASE_CHROMOSOME_ALIGNMENT": "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during meiotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. [GOC:vw]", "GOBP_MEIOTIC_SISTER_CHROMATID_COHESION": "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis. [GOC:ai]", "GOBP_MEIOTIC_SPINDLE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis. [GOC:tb, GOC:vw]", "GOBP_MEIOTIC_SPINDLE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle. [GOC:go_curators, GOC:mah]", "GOBP_MELANOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. [GOC:mah]", "GOBP_MELANOCYTE_PROLIFERATION": "The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. [CL:0000148, GOC:uh, PMID:22637532]", "GOBP_MELANOSOME_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22511774]", "GOBP_MEMBRANE_BIOGENESIS": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. [GOC:jl]", "GOBP_MEMBRANE_DEPOLARIZATION_DURING_AV_NODE_CELL_ACTION_POTENTIAL": "The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_MEMBRANE_DEPOLARIZATION": "The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dh, Wikipedia:Depolarization]", "GOBP_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL": "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_MEMBRANE_DEPOLARIZATION_DURING_SA_NODE_CELL_ACTION_POTENTIAL": "The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_MEMBRANE_DISASSEMBLY": "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. [GOC:mah]", "GOBP_MEMBRANE_DOCKING": "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. [GOC:isa_complete, PMID:27875684]", "GOBP_MEMBRANE_FUSION_INVOLVED_IN_VIRAL_ENTRY_INTO_HOST_CELL": "", "GOBP_MEMBRANE_FISSION": "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_MEMBRANE_HYPERPOLARIZATION": "The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. [GOC:dph]", "GOBP_MEMBRANE_FUSION": "The membrane organization process that joins two lipid bilayers to form a single membrane. [GOC:dph, GOC:tb]", "GOBP_MEMBRANE_INVAGINATION": "The infolding of a membrane. [GOC:tb]", "GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. [GOC:ai]", "GOBP_MEMBRANE_LIPID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. [GOC:ai]", "GOBP_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS": "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:jl, PMID:24227200]", "GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. [GOC:ai]", "GOBP_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS": "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. [PMID:12808018]", "GOBP_MEMBRANE_RAFT_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes. [PMID:12648772, PMID:12803918, PMID:16645198]", "GOBP_MEMBRANE_RAFT_LOCALIZATION": "Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. [GOC:ai, PMID:16645198]", "GOBP_MEMBRANE_PROTEIN_PROTEOLYSIS": "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. [GOC:pde]", "GOBP_MEMBRANE_RAFT_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_MEMBRANE_ORGANIZATION": "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. [GOC:dph, GOC:tb]", "GOBP_MEMBRANE_REPOLARIZATION": "The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_MEMBRANE_REPOLARIZATION_DURING_ATRIAL_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]", "GOBP_MEMBRANE_REPOLARIZATION_DURING_ACTION_POTENTIAL": "The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_MEMBRANE_REPOLARIZATION_DURING_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]", "GOBP_MEMBRANE_TO_MEMBRANE_DOCKING": "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere. [GOC:isa_complete]", "GOBP_MEMBRANOUS_SEPTUM_MORPHOGENESIS": "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. [GOC:mtg_heart]", "GOBP_MEMBRANE_TUBULATION": "A membrane organization process resulting in the formation of a tubular projection. This may face inwardly (as in tubular membrane invaginations) or outwardly (as in endosomal tubules). [GOC:pr]", "GOBP_MESANGIAL_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]", "GOBP_MEMORY": "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). [GOC:curators, ISBN:0582227089]", "GOBP_MESANGIAL_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]", "GOBP_MESENCHYMAL_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833]", "GOBP_MESENCHYMAL_CELL_DEVELOPMENT": "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. [GOC:dh, GOC:ef]", "GOBP_MESENCHYMAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]", "GOBP_MESENCHYMAL_CELL_MIGRATION": "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism. [GOC:dph, GOC:tb]", "GOBP_MESENCHYMAL_CELL_PROLIFERATION_INVOLVED_IN_LUNG_DEVELOPMENT": "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:dph]", "GOBP_MESENCHYMAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. [GOC:dph, GOC:jid]", "GOBP_MESENCHYMAL_CELL_PROLIFERATION": "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:dph, GOC:tb]", "GOBP_MESENCHYMAL_EPITHELIAL_CELL_SIGNALING": "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. [GOC:dph]", "GOBP_MESENCHYMAL_STEM_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [CL:0002452, GOC:BHF]", "GOBP_MESENCHYMAL_STEM_CELL_MAINTENANCE_INVOLVED_IN_NEPHRON_MORPHOGENESIS": "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [GOC:mtg_kidney_jan10]", "GOBP_MESENCHYMAL_STEM_CELL_PROLIFERATION": "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. [CL:0000134, GOC:yaf, PMID:20626275]", "GOBP_MESENCHYMAL_TO_EPITHELIAL_TRANSITION": "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_MESENCHYMAL_TO_EPITHELIAL_TRANSITION_INVOLVED_IN_METANEPHROS_MORPHOGENESIS": "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. [GOC:dph, GOC:yaf]", "GOBP_MESENCHYME_MIGRATION": "The process in which the population of cells that make up a mesenchyme undergo directed movement. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_MESODERMAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. [GOC:dgh]", "GOBP_MESENCHYME_MORPHOGENESIS": "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. [GOC:mtg_kidney_jan10]", "GOBP_MESODERMAL_CELL_FATE_COMMITMENT": "The cell differentiation process that results in commitment of a cell to become part of the mesoderm. [GOC:go_curators, ISBN:0878932437]", "GOBP_MESENCHYME_DEVELOPMENT": "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. [GOC:dph]", "GOBP_MESENDODERM_DEVELOPMENT": "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues. [GOC:jid]", "GOBP_MESODERMAL_CELL_MIGRATION": "The orderly movement of mesodermal cells from one site to another. [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047]", "GOBP_MESODERMAL_CELL_FATE_SPECIFICATION": "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. [GOC:go_curators]", "GOBP_MESODERM_MORPHOGENESIS": "The process in which the anatomical structures of the mesoderm are generated and organized. [GOC:go_curators]", "GOBP_MESODERM_DEVELOPMENT": "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. [GOC:dph, GOC:tb]", "GOBP_MESONEPHRIC_DUCT_DEVELOPMENT": "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros. [GOC:mtg_kidney_jan10]", "GOBP_MESONEPHRIC_TUBULE_FORMATION": "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros. [GOC:mtg_kidney_jan10]", "GOBP_MESONEPHRIC_TUBULE_MORPHOGENESIS": "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_EPITHELIUM_DEVELOPMENT": "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_COLLECTING_DUCT_DEVELOPMENT": "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder. [GOC:mtg_kidney_jan10]", "GOBP_METALLO_SULFUR_CLUSTER_ASSEMBLY": "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. [GOC:jl, GOC:mah, GOC:pde, GOC:vw]", "GOBP_METANEPHRIC_DISTAL_TUBULE_DEVELOPMENT": "The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule. [GOC:mtg_kidney_jan10]", "GOBP_MESONEPHROS_DEVELOPMENT": "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314]", "GOBP_METANEPHRIC_GLOMERULAR_MESANGIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_GLOMERULUS_DEVELOPMENT": "The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros. [GOC:mah]", "GOBP_METANEPHRIC_GLOMERULUS_VASCULATURE_DEVELOPMENT": "The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_LOOP_OF_HENLE_DEVELOPMENT": "The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_MESENCHYME_DEVELOPMENT": "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_MESENCHYMAL_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_NEPHRON_MORPHOGENESIS": "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_NEPHRON_DEVELOPMENT": "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_NEPHRON_TUBULE_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_NEPHRON_TUBULE_MORPHOGENESIS": "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS": "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_PART_OF_URETERIC_BUD_DEVELOPMENT": "The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_S_SHAPED_BODY_MORPHOGENESIS": "The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_PROXIMAL_TUBULE_DEVELOPMENT": "The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_TUBULE_FORMATION": "The developmental process pertaining to the initial formation of a metanephric tubule. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHRIC_TUBULE_DEVELOPMENT": "", "GOBP_METANEPHRIC_TUBULE_MORPHOGENESIS": "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros. [GOC:mtg_kidney_jan10]", "GOBP_METANEPHROS_MORPHOGENESIS": "The process in which the anatomical structures of the metanephros are generated and organized. [GOC:dph, GOC:yaf]", "GOBP_METAPHASE_ANAPHASE_TRANSITION_OF_MEIOTIC_CELL_CYCLE": "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis. [GOC:mtg_cell_cycle]", "GOBP_METANEPHROS_DEVELOPMENT": "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:bf, ISBN:0192800752]", "GOBP_METHIONINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]", "GOBP_METENCEPHALON_DEVELOPMENT": "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_METHIONINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]", "GOBP_METHYLGLYOXAL_METABOLIC_PROCESS": "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. [GOC:ai]", "GOBP_MHC_CLASS_II_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II. [GOC:go_curators]", "GOBP_METAPHASE_CHROMOSOME_ALIGNMENT": "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. [GOC:vw]", "GOBP_MHC_CLASS_I_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I. [GOC:go_curators]", "GOBP_MICROAUTOPHAGY": "A type of autophagy where cytosolic components are ingested by late endosomes, lysosomes or yeast-type lytic vacuoles by direct invagination of the compartment membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964]", "GOBP_MICROGLIAL_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_METHYLATION": "The process in which a methyl group is covalently attached to a molecule. [GOC:mah]", "GOBP_MICROGLIAL_CELL_MEDIATED_CYTOTOXICITY": "The directed killing of a target cell by a microglial cell. [GOC:BHF, GOC:nc, PMID:19100238]", "GOBP_MICROGLIAL_CELL_MIGRATION": "The orderly movement of a microglial cell from one site to another. [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]", "GOBP_MICROGLIAL_CELL_PROLIFERATION": "The expansion of a microglial cell population by cell division. [GOC:dph, PMID:17344397]", "GOBP_MICROGLIA_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system. [GOC:ef]", "GOBP_MICROTUBULE_ANCHORING": "Any process in which a microtubule is maintained in a specific location in a cell. [GOC:mah]", "GOBP_MICROTUBULE_ANCHORING_AT_MICROTUBULE_ORGANIZING_CENTER": "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center. [GOC:BHF, PMID:19825938]", "GOBP_MICROTUBULE_BASED_PROTEIN_TRANSPORT": "", "GOBP_MICROTUBULE_BUNDLE_FORMATION": "A process that results in a parallel arrangement of microtubules. [GOC:dph]", "GOBP_MICROTUBULE_BASED_TRANSPORT": "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. [GOC:cjm, ISBN:0815316194]", "GOBP_MICROTUBULE_BASED_MOVEMENT": "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. [GOC:cjm, ISBN:0815316194]", "GOBP_MICROTUBULE_DEPOLYMERIZATION": "The removal of tubulin heterodimers from one or both ends of a microtubule. [ISBN:0815316194]", "GOBP_MICROTUBULE_NUCLEATION_BY_MICROTUBULE_ORGANIZING_CENTER": "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center. [GOC:ai]", "GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS": "Any microtubule cytoskeleton organization that is involved in mitosis. [GO_REF:0000060, GOC:TermGenie, PMID:18799626]", "GOBP_MICROTUBULE_NUCLEATION": "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). [GOC:go_curators, ISBN:0815316194, PMID:12517712]", "GOBP_MICROTUBULE_BASED_PROCESS": "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. [GOC:mah]", "GOBP_MICROTUBULE_ORGANIZING_CENTER_LOCALIZATION": "Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell. [PMID:21281821]", "GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah]", "GOBP_MICROTUBULE_POLYMERIZATION": "The addition of tubulin heterodimers to one or both ends of a microtubule. [GOC:ai, GOC:go_curators]", "GOBP_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION": "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. [GOC:mah]", "GOBP_MICROTUBULE_SEVERING": "The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends. [GOC:ai, PMID:27037673]", "GOBP_MICROVILLUS_ASSEMBLY": "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. [GOC:mah, ISBN:0815316194]", "GOBP_MICROVILLUS_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. [GOC:mah]", "GOBP_MICTURITION": "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body. [GOC:dph]", "GOBP_MIDBODY_ABSCISSION": "The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells. [PMID:12737809, PMID:29903934]", "GOBP_MIDBRAIN_DOPAMINERGIC_NEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron. [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665]", "GOBP_MIDBRAIN_DEVELOPMENT": "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). [PMID:4975589, PMID:4992177]", "GOBP_MIDBRAIN_HINDBRAIN_BOUNDARY_DEVELOPMENT": "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. [GOC:dgh]", "GOBP_MIDDLE_EAR_MORPHOGENESIS": "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). [GOC:jl, ISBN:0192801023]", "GOBP_MIDGUT_DEVELOPMENT": "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. [GOC:jid, UBERON:0001045]", "GOBP_MINERALOCORTICOID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]", "GOBP_MIGRACYTOSIS": "A cell migration-dependent mechanism for releasing cellular contents. [PMID:25342562]", "GOBP_MINERALOCORTICOID_SECRETION": "", "GOBP_MIRNA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. [PMID:17993620]", "GOBP_MINERALOCORTICOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance. [ISBN:0198506732]", "GOBP_MIRNA_MEDIATED_GENE_SILENCING_BY_INHIBITION_OF_TRANSLATION": "An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. [PMID:14744438, PMID:15196554]", "GOBP_MIRNA_MEDIATED_GENE_SILENCING_BY_MRNA_DESTABILIZATION": "An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554, PMID:21118121, PMID:23209154]", "GOBP_MISMATCH_REPAIR": "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. [ISBN:0198506732, PMID:11687886]", "GOBP_MIRNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. [PMID:17993620]", "GOBP_MITOCHONDRIAL_ATP_TRANSMEMBRANE_TRANSPORT": "The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:18485069]", "GOBP_MIRNA_PROCESSING": "A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts. [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604]", "GOBP_MITOCHONDRIAL_ADP_TRANSMEMBRANE_TRANSPORT": "The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion. [PMID:2541251]", "GOBP_MITOCHONDRIAL_DEPOLARIZATION": "The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level. [Wikipedia:Depolarization, Wikipedia:Mitochondrion]", "GOBP_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. [GOC:ai, GOC:mah]", "GOBP_MITOCHONDRIAL_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT": "The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:ai]", "GOBP_MITOCHONDRIAL_DNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving mitochondrial DNA. [GOC:mah]", "GOBP_MITOCHONDRIAL_DNA_REPLICATION": "The process in which new strands of DNA are synthesized in the mitochondrion. [GOC:ai]", "GOBP_MITOCHONDRIAL_ELECTRON_TRANSPORT_SUCCINATE_TO_UBIQUINONE": "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II. [ISBN:0716731363]", "GOBP_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN": "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. [ISBN:0716731363]", "GOBP_MITOCHONDRIAL_DNA_REPAIR": "The process of restoring mitochondrial DNA after damage. [PMID:12565799, PMID:15189144, PMID:16050976]", "GOBP_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE": "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. [ISBN:0716731363]", "GOBP_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C": "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. [ISBN:0716731363]", "GOBP_MITOCHONDRIAL_FISSION": "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [PMID:11038192]", "GOBP_MITOCHONDRIAL_FRAGMENTATION_INVOLVED_IN_APOPTOTIC_PROCESS": "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form. [GOC:mtg_apoptosis, GOC:rk, PMID:12867994]", "GOBP_MITOCHONDRIAL_FUSION": "Merging of two or more mitochondria within a cell to form a single compartment. [PMID:11038192, PMID:12052774]", "GOBP_MITOCHONDRIAL_GENE_EXPRESSION": "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. [PMID:27058308]", "GOBP_MITOCHONDRIAL_GENOME_MAINTENANCE": "", "GOBP_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION": "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309]", "GOBP_MITOCHONDRIAL_MEMBRANE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]", "GOBP_MITOCHONDRIAL_PROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure. [GOC:sp, PMID:21264221, PMID:21264228]", "GOBP_MITOCHONDRIAL_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane. [GOC:mah]", "GOBP_MITOCHONDRIAL_PROTEIN_PROCESSING": "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. [GOC:curators]", "GOBP_MITOCHONDRIAL_RESPIRASOME_ASSEMBLY": "The aggregation, arrangement and bonding together of respiratory enzyme complexes I, III and IV of the mitochondrial inner membrane to form a large supercomplex. [PMID:30030361, PMID:32311046]", "GOBP_MITOCHONDRIAL_RIBOSOME_ASSEMBLY": "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits. [GOC:dph]", "GOBP_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex or between respiratory chain complexes to form high-order structures. [GOC:mah]", "GOBP_MITOCHONDRIAL_RNA_3_END_PROCESSING": "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion. [GOC:krc, GOC:mah]", "GOBP_MITOCHONDRIAL_RNA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. [GOC:krc, GOC:mah]", "GOBP_MITOCHONDRIAL_RNA_MODIFICATION": "Any RNA modification that takes place in mitochondrion. [GOC:TermGenie]", "GOBP_MITOCHONDRIAL_RNA_PROCESSING": "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. [GOC:krc, GOC:mah]", "GOBP_MITOCHONDRIAL_TRANSCRIPTION": "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. [GOC:jl, PMID:23632312]", "GOBP_MITOCHONDRIAL_RNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. [GOC:krc, GOC:mah]", "GOBP_MITOCHONDRIAL_TRANSLATIONAL_ELONGATION": "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion. [GOC:mah]", "GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT": "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. [PMID:20533899]", "GOBP_MITOCHONDRIAL_TRANSLATION": "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. [GOC:go_curators]", "GOBP_MITOCHONDRIAL_TRNA_PROCESSING": "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion. [GOC:vw]", "GOBP_MITOCHONDRION_DISTRIBUTION": "Any process that establishes the spatial arrangement of mitochondria between and within cells. [GOC:jid]", "GOBP_MITOCHONDRIAL_TRANSPORT": "Transport of substances into, out of or within a mitochondrion. [GOC:ai]", "GOBP_MITOCHONDRION_ENDOPLASMIC_RETICULUM_MEMBRANE_TETHERING": "The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. [PMID:19556461, PMID:27875684]", "GOBP_MITOCHONDRION_LOCALIZATION": "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. [GOC:ai]", "GOBP_MITOPHAGY": "The selective autophagy process in which a mitochondrion is degraded by macroautophagy. [PMID:15798367]", "GOBP_MITOCHONDRION_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]", "GOBP_MITOTIC_CHROMOSOME_CONDENSATION": "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. [GOC:mah, ISBN:0815316194]", "GOBP_MITOTIC_CELL_CYCLE_CHECKPOINT_SIGNALING": "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. [GOC:mtg_cell_cycle]", "GOBP_MITOTIC_CYTOKINESIS": "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. [GOC:mtg_cell_cycle]", "GOBP_MITOTIC_CELL_CYCLE_PHASE_TRANSITION": "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. [GOC:mtg_cell_cycle]", "GOBP_MITOTIC_CYTOKINETIC_PROCESS": "Any cytokinetic process that is involved in mitotic cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_MITOTIC_CELL_CYCLE": "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194]", "GOBP_MITOTIC_DNA_REPLICATION": "Any nuclear DNA replication that is involved in a mitotic cell cycle. [GO_REF:0000060, GOC:TermGenie]", "GOBP_MITOTIC_DNA_INTEGRITY_CHECKPOINT_SIGNALING": "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. [GOC:mtg_cell_cycle]", "GOBP_MITOTIC_DNA_REPLICATION_CHECKPOINT_SIGNALING": "A signal transduction process that contributes to a mitotic DNA replication checkpoint. [GOC:mtg_cell_cycle]", "GOBP_MITOTIC_CELL_CYCLE_PROCESS": "A process that is part of the mitotic cell cycle. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_MITOTIC_G1_S_TRANSITION_CHECKPOINT_SIGNALING": "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]", "GOBP_MITOTIC_INTRA_S_DNA_DAMAGE_CHECKPOINT_SIGNALING": "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. [GOC:vw]", "GOBP_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT_SIGNALING": "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. [GOC:mtg_cell_cycle, PMID:16299494]", "GOBP_MITOTIC_G2_M_TRANSITION_CHECKPOINT": "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]", "GOBP_MITOTIC_METAPHASE_CHROMOSOME_ALIGNMENT": "A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. [ISBN:0815316194]", "GOBP_MITOTIC_NUCLEAR_MEMBRANE_DISASSEMBLY": "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. [GOC:bf, PMID:32848252]", "GOBP_MITOTIC_RECOMBINATION": "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles. [GOC:elh]", "GOBP_MITOTIC_NUCLEAR_MEMBRANE_ORGANIZATION": "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. [GOC:vw, PMID:15147872]", "GOBP_MITOTIC_SISTER_CHROMATID_COHESION_CENTROMERIC": "The cell cycle process in which centromeres of sister chromatids are joined during mitosis. [GOC:mah]", "GOBP_MITOTIC_SISTER_CHROMATID_COHESION": "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]", "GOBP_MITOTIC_NUCLEAR_DIVISION": "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. [ISBN:0198547684]", "GOBP_MITOTIC_SISTER_CHROMATID_SEPARATION": "The process in which sister chromatids are physically detached from each other during mitosis. [GOC:ai]", "GOBP_MITOTIC_SPINDLE_ELONGATION": "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B. [GOC:mtg_cell_cycle, GOC:vw, PMID:19686686]", "GOBP_MITOTIC_SPINDLE_ASSEMBLY": "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. [GOC:tb, GOC:vw]", "GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION": "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. [GOC:ai, GOC:jl]", "GOBP_MITRAL_VALVE_DEVELOPMENT": "The progression of the mitral valve over time, from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_MODIFICATION_OF_POSTSYNAPTIC_ACTIN_CYTOSKELETON": "Any process that modifies the structure of a postsynaptic actin cytoskeleton. [GOC:dos]", "GOBP_MITOTIC_SPINDLE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. [GOC:go_curators, GOC:mah]", "GOBP_MODIFICATION_OF_POSTSYNAPTIC_STRUCTURE": "Any process that modifies the structure of a postsynapse. [GOC:dos]", "GOBP_MODIFICATION_OF_SYNAPTIC_STRUCTURE": "Any process that modifies the structure/morphology of a synapse. [GOC:dos]", "GOBP_MODULATION_BY_HOST_OF_SYMBIONT_PROCESS": "", "GOBP_MODIFIED_AMINO_ACID_TRANSPORT": "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_MODULATION_BY_HOST_OF_VIRAL_GENOME_REPLICATION": "", "GOBP_MODULATION_BY_HOST_OF_VIRAL_PROCESS": "", "GOBP_MODULATION_BY_HOST_OF_VIRAL_RNA_GENOME_REPLICATION": "", "GOBP_MODIFICATION_DEPENDENT_MACROMOLECULE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule. [GOC:jl]", "GOBP_MODULATION_BY_SYMBIONT_OF_ENTRY_INTO_HOST": "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]", "GOBP_MODULATION_BY_VIRUS_OF_HOST_PROCESS": "", "GOBP_MODULATION_OF_INHIBITORY_POSTSYNAPTIC_POTENTIAL": "Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. [GOC:dos]", "GOBP_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL": "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dos]", "GOBP_MODULATION_OF_MICROTUBULE_CYTOSKELETON_INVOLVED_IN_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION": "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_MODULATION_OF_PROCESS_OF_ANOTHER_ORGANISM": "A process in which an organism effects a change in a biological process in another organism. [GOC:bf]", "GOBP_MONOACYLGLYCEROL_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [PMID:25290914]", "GOBP_MONOACYLGLYCEROL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [ISBN:0198506732]", "GOBP_MOLTING_CYCLE": "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. [GOC:jl, ISBN:0198506732]", "GOBP_MONOACYLGLYCEROL_METABOLIC_PROCESS": "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [ISBN:0198506732]", "GOBP_MOLTING_CYCLE_PROCESS": "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin. [GOC:isa_complete]", "GOBP_MONOATOMIC_ANION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of monoatomic anions within an organism or cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom. [GOC:ceb, GOC:jid, GOC:mah]", "GOBP_MONOAMINE_TRANSPORT": "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT": "", "GOBP_MONOATOMIC_ANION_TRANSPORT": "The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. [GOC:ai]", "GOBP_MONOCYTE_ACTIVATION": "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]", "GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. [GOC:mah]", "GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. [GOC:mah]", "GOBP_MONOCYTE_AGGREGATION": "The adhesion of one monocyte to one or more other monocytes via adhesion molecules. [GOC:sl, PMID:12972508]", "GOBP_MONOATOMIC_ION_TRANSPORT": "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]", "GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT": "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah]", "GOBP_MONOATOMIC_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]", "GOBP_MONOCARBOXYLIC_ACID_TRANSPORT": "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_MONOATOMIC_CATION_TRANSPORT": "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. [GOC:ai]", "GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). [GOC:vk]", "GOBP_MONOCYTE_CHEMOTACTIC_PROTEIN_1_PRODUCTION": "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:rv]", "GOBP_MONOCYTE_EXTRAVASATION": "The migration of a monocyte from the blood vessels into the surrounding tissue. [CL:0000576, GOC:BHF, PMID:10657654]", "GOBP_MONOCYTE_CHEMOTAXIS": "The movement of a monocyte in response to an external stimulus. [GOC:add, PMID:11696603, PMID:15173832]", "GOBP_MONOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah]", "GOBP_MONOSACCHARIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. [ISBN:0198506732]", "GOBP_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. [ISBN:0198506732]", "GOBP_MONONUCLEAR_CELL_MIGRATION": "The movement of a mononuclear cell within or between different tissues and organs of the body. [GOC:mah]", "GOBP_MONOTERPENOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton. [ISBN:0198547684]", "GOBP_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORT": "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. [GO_REF:0000069, GOC:TermGenie, GOC:vw]", "GOBP_MONONUCLEAR_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]", "GOBP_MONOSACCHARIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. [ISBN:0198506732]", "GOBP_MONOUBIQUITINATED_PROTEIN_DEUBIQUITINATION": "The removal of the ubiquitin group from a monoubiquitinated protein. [GOC:bf]", "GOBP_MORPHOGENESIS_OF_AN_ENDOTHELIUM": "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. [GOC:mtg_heart]", "GOBP_MORPHOGENESIS_OF_AN_EPITHELIAL_BUD": "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. [GOC:dph]", "GOBP_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD": "The morphogenetic process in which an epithelial sheet bends along a linear axis. [GOC:dph]", "GOBP_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET": "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. [GOC:jl]", "GOBP_MOTOR_NEURON_APOPTOTIC_PROCESS": "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086]", "GOBP_MOTOR_BEHAVIOR": "The specific neuromuscular movement of a single organism in response to external or internal stimuli. [GOC:bf, GOC:PARL, PMID:25318560]", "GOBP_MOTOR_LEARNING": "Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience. [GOC:bf, GOC:PARL, Wikipedia:Motor_learning]", "GOBP_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM": "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. [GOC:dph]", "GOBP_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE": "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. [ISBN:0721662544]", "GOBP_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM": "The process in which the anatomical structures of embryonic epithelia are generated and organized. [GOC:jl]", "GOBP_MOTILE_CILIUM_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a motile cilium. [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]", "GOBP_MOTOR_NEURON_MIGRATION": "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. [CL:0000100, GOC:yaf, PMID:20711475]", "GOBP_MOTOR_NEURON_AXON_GUIDANCE": "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. [CL:0000100, GOC:pr, ISBN:0878932437]", "GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM": "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]", "GOBP_MRNA_3_END_PROCESSING_BY_STEM_LOOP_BINDING_AND_CLEAVAGE": "Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine. [GOC:mah, GOC:tb, PMID:17998288]", "GOBP_MRNA_3_END_PROCESSING": "Any process involved in forming the mature 3' end of an mRNA molecule. [GOC:mah]", "GOBP_MRNA_5_SPLICE_SITE_RECOGNITION": "Recognition of the intron 5'-splice site by components of the assembling spliceosome. [GOC:krc, ISBN:0879695897]", "GOBP_MRNA_3_SPLICE_SITE_RECOGNITION": "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome. [GOC:krc, ISBN:0879695897]", "GOBP_MRNA_METHYLGUANOSINE_CAP_DECAPPING": "Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA. [PMID:23287066]", "GOBP_MRNA_MODIFICATION": "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. [GOC:curators]", "GOBP_MRNA_CIS_SPLICING_VIA_SPLICEOSOME": "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. [GOC:krc, ISBN:0879695897, PMID:18458335]", "GOBP_MRNA_EXPORT_FROM_NUCLEUS": "The directed movement of mRNA from the nucleus to the cytoplasm. [GOC:ma]", "GOBP_MRNA_PSEUDOURIDINE_SYNTHESIS": "The intramolecular conversion of uridine to pseudouridine in an mRNA molecule. [PMID:25192136]", "GOBP_MRNA_SPLICE_SITE_RECOGNITION": "Selection of a splice site by components of the assembling spliceosome. [GOC:krc, ISBN:0879695897]", "GOBP_MRNA_TRANSCRIPTION": "The cellular synthesis of messenger RNA (mRNA) from a DNA template. [GOC:jl]", "GOBP_MRNA_TRANSPORT": "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_MRNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. [ISBN:0198506732]", "GOBP_MRNA_PROCESSING": "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. [GOC:mah]", "GOBP_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS": "", "GOBP_MUCOCILIARY_CLEARANCE": "The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways. [GOC:krc, PMID:24119105, PMID:27864314]", "GOBP_MUCOSA_ASSOCIATED_LYMPHOID_TISSUE_DEVELOPMENT": "The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes. [GOC:add, ISBN:0781735149]", "GOBP_MUCUS_SECRETION": "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. [GOC:add, ISBN:068340007X, ISBN:0721662544]", "GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_CHEMICAL_HOMEOSTASIS": "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. [GOC:curators]", "GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_IRON_ION_HOMEOSTASIS": "A chemical homeostatic process involved in the maintenance of a steady state level of iron within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. [PMID:31431773]", "GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_WATER_HOMEOSTASIS": "A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. [GOC:dph, GOC:tb]", "GOBP_MULTICELLULAR_ORGANISMAL_MOVEMENT": "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. [GOC:dph, GOC:mtg_muscle, GOC:tb]", "GOBP_MULTINUCLEAR_OSTEOCLAST_DIFFERENTIATION": "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000779, GOC:mah, PMID:12713016]", "GOBP_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS": "Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mah]", "GOBP_MULTIVESICULAR_BODY_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. [GOC:sart, PMID:11566881]", "GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. [GOC:isa_complete]", "GOBP_MULTICELLULAR_ORGANISM_GROWTH": "The increase in size or mass of an entire multicellular organism, as opposed to cell growth. [GOC:bf, GOC:curators, GOC:dph, GOC:tb]", "GOBP_MULTICELLULAR_ORGANISMAL_REPRODUCTIVE_PROCESS": "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. [GOC:dph, GOC:jid, GOC:tb]", "GOBP_MULTIVESICULAR_BODY_SORTING_PATHWAY": "A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. [GOC:mah, PMID:17603537]", "GOBP_MULTI_CILIATED_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224]", "GOBP_MULTI_PASS_TRANSMEMBRANE_PROTEIN_INSERTION_INTO_ER_MEMBRANE": "A process of protein insertion of multi-pass membrane proteins into the endoplasmic reticulum (ER) membrane. Insertion of multi-pass membrane proteins is mediated by the multi-pass translocon complex and takes place following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex to promote insertion of subsequent transmembrane regions. [PMID:36261522, PMID:36261528]", "GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS": "A multicellular organism process which involves another multicellular organism of the same or different species. [GOC:jl]", "GOBP_MUSCLE_ADAPTATION": "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]", "GOBP_MUSCLE_ATROPHY": "A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. [GOC:mtg_muscle]", "GOBP_MUSCLE_CELL_CELLULAR_HOMEOSTASIS": "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. [GOC:mah, PMID:3091429, PMID:7781901]", "GOBP_MUSCLE_CELL_APOPTOTIC_PROCESS": "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_MUSCLE_CELL_FATE_COMMITMENT": "The process in which the cellular identity of muscle cells is acquired and determined. [CL:0000187, GOC:go_curators]", "GOBP_MUSCLE_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. [CL:0000187, GOC:devbiol]", "GOBP_MUSCLE_CELL_MIGRATION": "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. [CL:0000187, GOC:mtg_muscle]", "GOBP_MUSCLE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. [CL:0000187, GOC:go_curators]", "GOBP_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS": "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. [GOC:mtg_heart]", "GOBP_MUSCLE_CELL_PROLIFERATION": "The expansion of a muscle cell population by cell division. [CL:0000187, GOC:mah]", "GOBP_MUSCLE_HYPERTROPHY": "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. [GOC:mtg_muscle]", "GOBP_MUSCLE_ORGAN_MORPHOGENESIS": "The process in which the anatomical structures of muscle are generated and organized. [GOC:jid]", "GOBP_MUSCLE_CONTRACTION": "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]", "GOBP_MUSCLE_ORGAN_DEVELOPMENT": "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. [GOC:jid, ISBN:0198506732]", "GOBP_MUSCULAR_SEPTUM_MORPHOGENESIS": "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. [GOC:mtg_heart]", "GOBP_MUSCLE_STRUCTURE_DEVELOPMENT": "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. [GOC:dph]", "GOBP_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY": "A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]", "GOBP_MYCOTOXIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus. [GOC:jl]", "GOBP_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY": "A toll-like receptor signaling pathway not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate an immune response. [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]", "GOBP_MYELIN_ASSEMBLY": "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. [GOC:dgh, GOC:dph, GOC:tb]", "GOBP_MYELIN_MAINTENANCE": "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. [GOC:dgh]", "GOBP_MUSCLE_TISSUE_DEVELOPMENT": "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. [GOC:dph]", "GOBP_MUSCLE_SYSTEM_PROCESS": "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. [GOC:mtg_cardio]", "GOBP_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_MYELOID_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. [GOC:dph]", "GOBP_MYELOID_DENDRITIC_CELL_ACTIVATION": "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]", "GOBP_MYELOID_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093]", "GOBP_MYELOID_DENDRITIC_CELL_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a myeloid dendritic cell. [GOC:add, ISBN:0781735149]", "GOBP_MYELOID_CELL_HOMEOSTASIS": "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [CL:0000763, GOC:add]", "GOBP_MYELOID_DENDRITIC_CELL_DIFFERENTIATION": "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. [CL:0000782, GOC:jl]", "GOBP_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a myeloid cell. [GOC:dph]", "GOBP_MYELOID_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. [GOC:add, ISBN:0781735149]", "GOBP_MYELOID_LEUKOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. [GOC:add, PMID:16551251]", "GOBP_MYELOID_LEUKOCYTE_ACTIVATION": "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:add, ISBN:0781735149]", "GOBP_MYELOID_PROGENITOR_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. [GOC:add, PMID:16551264]", "GOBP_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY": "Any process involved in the carrying out of an immune response by a myeloid leukocyte. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_MYOBLAST_FATE_COMMITMENT": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:dph, GOC:mtg_muscle]", "GOBP_MYOBLAST_FUSION_INVOLVED_IN_SKELETAL_MUSCLE_REGENERATION": "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]", "GOBP_MYELOID_LEUKOCYTE_MIGRATION": "The movement of a myeloid leukocyte within or between different tissues and organs of the body. [GOC:cvs, PMID:22342843, PMID:24157461]", "GOBP_MYOBLAST_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]", "GOBP_MYOBLAST_FUSION": "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]", "GOBP_MYOBLAST_MIGRATION": "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ai, GOC:mtg_muscle]", "GOBP_MYOFIBROBLAST_DIFFERENTIATION": "The process in which an undifferentiated cell acquires the features of a myofibroblast cell. [CL:0000186, GOC:nhn]", "GOBP_MYOBLAST_PROLIFERATION": "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:ai, GOC:mtg_muscle]", "GOBP_MYOSIN_FILAMENT_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules. [GOC:mah]", "GOBP_MYOTUBE_DIFFERENTIATION_INVOLVED_IN_SKELETAL_MUSCLE_REGENERATION": "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]", "GOBP_MYOTUBE_CELL_DEVELOPMENT": "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]", "GOBP_NADH_METABOLIC_PROCESS": "", "GOBP_NADPH_OXIDATION": "", "GOBP_NADH_OXIDATION": "", "GOBP_NADPH_REGENERATION": "A metabolic process that generates a pool of NADPH by the reduction of NADP+. [GOC:mah]", "GOBP_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. [GOC:sm]", "GOBP_MYOTUBE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]", "GOBP_NADP_METABOLIC_PROCESS": "", "GOBP_NAD_BIOSYNTHESIS_VIA_NICOTINAMIDE_RIBOSIDE_SALVAGE_PATHWAY": "", "GOBP_NAD_CATABOLIC_PROCESS": "", "GOBP_NAD_METABOLIC_PROCESS": "", "GOBP_NAD_TRANSMEMBRANE_TRANSPORT": "The process in which a nicotinamide adenine dinucleotide is transported across a membrane; transport may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:bf]", "GOBP_NAD_TRANSPORT": "The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:jl]", "GOBP_NAIL_DEVELOPMENT": "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it. [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)]", "GOBP_NATURAL_KILLER_CELL_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a natural killer cell. [GOC:add, ISBN:0781735149]", "GOBP_NATURAL_KILLER_CELL_CHEMOTAXIS": "The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [CL:0000623, GOC:BHF]", "GOBP_NATURAL_KILLER_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. [GOC:add, ISBN:0781735149]", "GOBP_NATURAL_KILLER_CELL_DEGRANULATION": "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell. [ISBN:0781735149]", "GOBP_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, PMID:15032583]", "GOBP_NATURAL_KILLER_CELL_ACTIVATION": "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]", "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL": "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]", "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY": "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_NATURAL_KILLER_CELL_PROLIFERATION": "The expansion of a natural killer cell population by cell division. [GOC:add, ISBN:0781735149]", "GOBP_NECROPTOTIC_PROCESS": "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153]", "GOBP_NECROPTOTIC_SIGNALING_PATHWAY": "The series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered. [GOC:mtg_apoptosis, PMID:20823910]", "GOBP_NEGATIVE_ADAPTATION_OF_SIGNALING_PATHWAY": "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. [GOC:isa_complete]", "GOBP_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_GENOME_REPLICATION": "", "GOBP_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS": "", "GOBP_NEGATIVE_CHEMOTAXIS": "The directed movement of a motile cell or organism towards a lower concentration of a chemical. [GOC:ai, GOC:bf, GOC:isa_complete]", "GOBP_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION": "", "GOBP_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_ACTIN_NUCLEATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_ACTION_POTENTIAL": "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl]", "GOBP_NEGATIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. [GOC:BHF, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]", "GOBP_NEGATIVE_REGULATION_OF_ADIPOSE_TISSUE_DEVELOPMENT": "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]", "GOBP_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]", "GOBP_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_AMINE_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_AMINO_ACID_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_AMYLOID_BETA_CLEARANCE": "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_AMYLOID_FIBRIL_FORMATION": "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]", "GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY": "Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_ANOIKIS": "Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]", "GOBP_NEGATIVE_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. [GO_REF:0000058, GOC:TermGenie, PMID:22801495]", "GOBP_NEGATIVE_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. [GOC:mah, PMID:16959963]", "GOBP_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_ASTROCYTE_ACTIVATION": "Any process that decreases the frequency, rate or extent of astrocyte activation. [GOC:aruk, GOC:bc, PMID:20005821]", "GOBP_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. [GOC:vp, PMID:15139015]", "GOBP_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_ATP_DEPENDENT_ACTIVITY": "Any process that stops or reduces the rate of an ATP-dependent activity. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY": "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly. [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012]", "GOBP_NEGATIVE_REGULATION_OF_AUTOPHAGOSOME_MATURATION": "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation. [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]", "GOBP_NEGATIVE_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy. [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]", "GOBP_NEGATIVE_REGULATION_OF_AUTOPHAGY": "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE": "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. [GOC:devbiol]", "GOBP_NEGATIVE_REGULATION_OF_AXONOGENESIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_BEHAVIOR": "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. [GOC:jid, GOC:pr]", "GOBP_NEGATIVE_REGULATION_OF_AXON_EXTENSION": "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY": "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly. [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]", "GOBP_NEGATIVE_REGULATION_OF_BINDING": "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT": "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION": "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]", "GOBP_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE": "Any process in which the force of blood traveling through the circulatory system is decreased. [GOC:go_curators, GOC:mtg_cardio]", "GOBP_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_PROLIFERATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS": "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23388056]", "GOBP_NEGATIVE_REGULATION_OF_BONE_MINERALIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_BONE_REMODELING": "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:23977283]", "GOBP_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_B_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the rate or extent of B cell proliferation. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CALCINEURIN_MEDIATED_SIGNALING": "Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signaling. [PMID:25081204]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT": "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT_VIA_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel. [GO_REF:0000058, GOC:TermGenie, PMID:23071515]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT": "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]", "GOBP_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING": "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. [GOC:ai, PMID:11696592]", "GOBP_NEGATIVE_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING": "", "GOBP_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_ADAPTATION": "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY": "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]", "GOBP_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. [GOC:vk]", "GOBP_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. [GOC:ecd]", "GOBP_NEGATIVE_REGULATION_OF_CARDIOCYTE_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]", "GOBP_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT": "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY": "Any process that stops or reduces the activity of an enzyme. [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]", "GOBP_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. [GOC:add, GOC:pr, ISBN:0781735149]", "GOBP_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPIRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration. [GOC:TermGenie, GOC:yaf, PMID:23150719]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_EXTRAVASATION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia. [GOC:TermGenie, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS": "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. [GOC:mah, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. [GOC:TermGenie, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE": "Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN": "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION_MOLECULE_PRODUCTION": "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. [GOC:BHF, GOC:rl]", "GOBP_NEGATIVE_REGULATION_OF_CELL_ACTIVATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CELL_CHEMOTAXIS_TO_FIBROBLAST_GROWTH_FACTOR": "Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]", "GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION": "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. [GOC:isa_complete]", "GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION": "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION": "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. [GO_REF:0000058, GOC:jl, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE": "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CELL_DIVISION": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CELL_FATE_COMMITMENT": "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CELL_GROWTH_INVOLVED_IN_CARDIAC_MUSCLE_CELL_DEVELOPMENT": "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS": "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT": "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CELL_GROWTH": "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CELL_KILLING": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY": "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION": "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. [GOC:hjd]", "GOBP_NEGATIVE_REGULATION_OF_CELL_MATURATION": "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. [GO_REF:0000058, GOC:TermGenie, PMID:17459944]", "GOBP_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development. [GOC:TermGenie, PMID:18182616]", "GOBP_NEGATIVE_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS": "Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CELL_SIZE": "Any process that reduces cell size. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CELL_VOLUME": "Any process that decreases cell volume. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION": "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. [GOC:dph, GOC:pf, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_JUNCTION_ORGANIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization. [GOC:aruk]", "GOBP_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CENTRIOLE_REPLICATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CENTROSOME_DUPLICATION": "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION": "Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CGAS_STING_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway. [PMID:29875158]", "GOBP_NEGATIVE_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process. [GOC:TermGenie, PMID:15302821]", "GOBP_NEGATIVE_REGULATION_OF_CHEMOKINE_C_C_MOTIF_LIGAND_5_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CGMP_MEDIATED_SIGNALING": "", "GOBP_NEGATIVE_REGULATION_OF_CHEMOKINE_C_X_C_MOTIF_LIGAND_2_PRODUCTION": "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. [GOC:BHF, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY": "Any process that decreases the rate, frequency or extent of a chemokine-mediated signaling pathway. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CHEMOTAXIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_EFFLUX": "Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:dph, GOC:tb, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS": "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_STORAGE": "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_CHROMATIN_ORGANIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]", "GOBP_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION": "", "GOBP_NEGATIVE_REGULATION_OF_CILIUM_ASSEMBLY": "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]", "GOBP_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_CHONDROCYTE_PROLIFERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]", "GOBP_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM": "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_COLLATERAL_SPROUTING": "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]", "GOBP_NEGATIVE_REGULATION_OF_COLD_INDUCED_THERMOGENESIS": "Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis. [PMID:27876809]", "GOBP_NEGATIVE_REGULATION_OF_COAGULATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_COMPLEMENT_ACTIVATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_CYCLASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY": "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]", "GOBP_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY": "", "GOBP_NEGATIVE_REGULATION_OF_CYTOKINESIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSLATION": "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE": "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway. [GOC:bf, GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION": "Any process that decreases the concentration of calcium ions in the cytosol. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION": "Any process that stops, prevents, or reduces the rate of production of a cytokine. [GOC:add, ISBN:0781735149]", "GOBP_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM": "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749]", "GOBP_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS": "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT": "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_DENDRITIC_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT": "Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS": "Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION": "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH": "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS": "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_DNA_BINDING": "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_DNA_CATABOLIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR": "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_DNA_REPLICATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_DNA_REPAIR": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS": "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_DNA_REPLICATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation. [GOC:mah, GOC:txnOH]", "GOBP_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]", "GOBP_NEGATIVE_REGULATION_OF_DOPAMINE_SECRETION": "", "GOBP_NEGATIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_NONHOMOLOGOUS_END_JOINING": "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination. [GOC:vw]", "GOBP_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_CALCIUM_ION_CONCENTRATION": "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]", "GOBP_NEGATIVE_REGULATION_OF_ENDOCYTOSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE": "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY": "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION": "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_EPINEPHRINE_SECRETION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine. [GOC:vk]", "GOBP_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT": "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19137015]", "GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT": "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_ERAD_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22590560]", "GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION": "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]", "GOBP_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. [GO_REF:0000058, GOC:TermGenie, PMID:22761445]", "GOBP_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION": "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:16857185]", "GOBP_NEGATIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS": "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. [GOC:mtg_apoptosis, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL": "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY": "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY": "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_EXOCYTOSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]", "GOBP_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_FATTY_ACID_BETA_OXIDATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS": "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. [GOC:TermGenie, PMID:17245429]", "GOBP_NEGATIVE_REGULATION_OF_FATTY_ACID_OXIDATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_FATTY_ACID_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_FAT_CELL_PROLIFERATION": "Any process that stops or decreases the rate or extent of fat cell proliferation. [GOC:mah, GOC:sl]", "GOBP_NEGATIVE_REGULATION_OF_FEEDING_BEHAVIOR": "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_FERROPTOSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis. [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465]", "GOBP_NEGATIVE_REGULATION_OF_FERTILIZATION": "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_PRODUCTION": "Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_FIBRINOLYSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_FIBROBLAST_MIGRATION": "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]", "GOBP_NEGATIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_G0_TO_G1_TRANSITION": "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_VIA_CHROMOSOMAL_CPG_ISLAND_METHYLATION": "An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes. [PMID:11898023, Wikipedia:Cpg_island]", "GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_APOPTOTIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_MIGRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]", "GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC": "An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. [PMID:22243696]", "GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION": "Any process that stops or decreases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_GLUCOCORTICOID_METABOLIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_GLIOGENESIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. [GOC:ef]", "GOBP_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION": "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]", "GOBP_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT": "", "GOBP_NEGATIVE_REGULATION_OF_GLUTAMATE_SECRETION": "", "GOBP_NEGATIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT": "", "GOBP_NEGATIVE_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS": "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_GONADOTROPIN_SECRETION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]", "GOBP_NEGATIVE_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY": "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649]", "GOBP_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT": "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. [GOC:BHF, GOC:rl, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_GROWTH": "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_HEART_RATE": "Any process that stops, prevents or reduces the frequency or rate of heart contraction. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_STEM_CELL_PROLIFERATION": "", "GOBP_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. [GOC:TermGenie, PMID:23403623]", "GOBP_NEGATIVE_REGULATION_OF_HEPATOCYTE_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:8649852]", "GOBP_NEGATIVE_REGULATION_OF_HIPPO_SIGNALING": "Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_HETEROCHROMATIN_FORMATION": "", "GOBP_NEGATIVE_REGULATION_OF_HEMOPOIESIS": "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]", "GOBP_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_HORMONE_SECRETION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_HYDROGEN_PEROXIDE_MEDIATED_PROGRAMMED_CELL_DEATH": "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_HYPOXIA_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24553947]", "GOBP_NEGATIVE_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. [GOC:dph, GOC:hjd, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY": "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_IMMATURE_T_CELL_PROLIFERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation. [GOC:add, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_INCLUSION_BODY_ASSEMBLY": "Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of an inflammasome-mediated signaling pathway. [PMID:33467177]", "GOBP_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_WOUNDING": "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821]", "GOBP_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS": "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:BHF, GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]", "GOBP_NEGATIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_ALPHA_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY": "", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_18_PRODUCTION": "", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_21_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production. [GOC:mah, PMID:29778524]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_5_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_MEDIATED_SIGNALING_PATHWAY": "Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway. [GOC:BHF, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT": "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. [GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]", "GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION": "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OSMOTIC_STRESS": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]", "GOBP_NEGATIVE_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE": "Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]", "GOBP_NEGATIVE_REGULATION_OF_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE": "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]", "GOBP_NEGATIVE_REGULATION_OF_JNK_CASCADE": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY": "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION": "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT": "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:tb, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY": "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL": "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]", "GOBP_NEGATIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY": "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]", "GOBP_NEGATIVE_REGULATION_OF_LENS_FIBER_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]", "GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION": "Any process that stops, prevents, or reduces the rate of leukocyte degranulation. [GOC:add, ISBN:0781735149]", "GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION": "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]", "GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. [GOC:add, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. [GO_REF:0000058, GOC:TermGenie, PMID:17564681]", "GOBP_NEGATIVE_REGULATION_OF_LIPID_STORAGE": "Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE": "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE": "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY": "", "GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_ACTIVATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY": "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS": "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION": "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:BHF, GOC:rl]", "GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION": "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_MIGRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]", "GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY": "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MAST_CELL_DEGRANULATION": "Any process that stops, prevents, or reduces the rate of mast cell degranulation. [ISBN:0781735149]", "GOBP_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MATRIX_METALLOPEPTIDASE_SECRETION": "Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion. [GO_REF:0000058, GOC:TermGenie, PMID:8679543]", "GOBP_NEGATIVE_REGULATION_OF_MAPK_CASCADE": "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE": "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE_PHASE_TRANSITION": "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "GOBP_NEGATIVE_REGULATION_OF_MEIOTIC_CHROMOSOME_SEPARATION": "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645]", "GOBP_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION": "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization. [GO_REF:0000058, GOC:TermGenie, PMID:20826763]", "GOBP_NEGATIVE_REGULATION_OF_MEMBRANE_PERMEABILITY": "Any process that stops, prevents or reduces the frequency, rate or extent of the passage or uptake of molecules by a membrane. [PMID:27482894]", "GOBP_NEGATIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_MEMBRANE_POTENTIAL": "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION": "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:mtg_kidney_jan10]", "GOBP_NEGATIVE_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_METALLOENDOPEPTIDASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_METALLOPEPTIDASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MICROGLIAL_CELL_ACTIVATION": "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]", "GOBP_NEGATIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_MIRNA_PROCESSING": "Any process that stops, prevents or reduces the frequency, rate or extent of microRNA processing. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]", "GOBP_NEGATIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_MITOCHONDRIAL_FUSION": "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_MIRNA_METABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE_PHASE_TRANSITION": "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "GOBP_NEGATIVE_REGULATION_OF_MONOATOMIC_ION_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE": "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_MONOCYTE_CHEMOTACTIC_PROTEIN_1_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION": "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GO:jl]", "GOBP_NEGATIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS": "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_MONOCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION": "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_MORPHOGENESIS_OF_AN_EPITHELIUM": "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]", "GOBP_NEGATIVE_REGULATION_OF_MOTOR_NEURON_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. [GOC:mtg_apoptosis, GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_MRNA_PROCESSING": "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH": "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. [GOC:dph, GOC:ems, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_MUSCLE_ADAPTATION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. [GOC:mtg_muscle]", "GOBP_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. [CL:0000187, GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT": "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. [GOC:mtg_muscle]", "GOBP_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT": "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. [GOC:TermGenie, GOC:yaf, PMID:23150719]", "GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_MYELINATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_MYOBLAST_PROLIFERATION": "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]", "GOBP_NEGATIVE_REGULATION_OF_MYOFIBROBLAST_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]", "GOBP_NEGATIVE_REGULATION_OF_MYOSIN_LIGHT_CHAIN_PHOSPHATASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION": "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. [GOC:dph, GOC:mah, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT": "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_NEUROINFLAMMATORY_RESPONSE": "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423]", "GOBP_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. [GOC:dph, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_NEURON_MIGRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_NEURON_PROJECTION_REGENERATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT": "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]", "GOBP_NEGATIVE_REGULATION_OF_NEUTROPHIL_MIGRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration. [GO_REF:0000058, GOC:TermGenie, PMID:1826836]", "GOBP_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. [GOC:dph, GOC:rl, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_NODAL_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway. [GOC:BHF, GOC:TermGenie, GOC:vk]", "GOBP_NEGATIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway. [GOC:obol, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_NOREPINEPHRINE_SECRETION": "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_NON_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION": "Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical NF-kappaB signaling cascade. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY": "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION": "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY": "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_NUCLEASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. [GOC:vp, PMID:15139015]", "GOBP_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY": "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. [GOC:pr, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION": "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_ORGAN_GROWTH": "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. [GOC:bf, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION": "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_OSTEOCLAST_DEVELOPMENT": "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_OSSIFICATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595]", "GOBP_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]", "GOBP_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY": "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_P38MAPK_CASCADE": "Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade. [GO_REF:0000058, GOC:TermGenie, PMID:18681888]", "GOBP_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY": "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PANCREATIC_JUICE_SECRETION": "Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PEPTIDYL_CYSTEINE_S_NITROSYLATION": "", "GOBP_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION": "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE": "Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]", "GOBP_NEGATIVE_REGULATION_OF_PHAGOCYTOSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_PROTEIN_KINASE_B_SIGNAL_TRANSDUCTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10657240]", "GOBP_NEGATIVE_REGULATION_OF_PLASMINOGEN_ACTIVATION": "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PINOCYTOSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_PHOTORECEPTOR_CELL_DIFFERENTIATION": "", "GOBP_NEGATIVE_REGULATION_OF_PLATELET_AGGREGATION": "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_PHOSPHORYLATION": "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION": "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PLASMA_MEMBRANE_BOUNDED_CELL_PROJECTION_ASSEMBLY": "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. [GOC:krc]", "GOBP_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_POST_TRANSCRIPTIONAL_GENE_SILENCING": "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT": "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_POST_TRANSLATIONAL_PROTEIN_MODIFICATION": "Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification. [GOC:TermGenie, GOC:yaf, PMID:21209915]", "GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_NECROTIC_CELL_DEATH": "Any process that decreases the frequency, rate or extent of programmed necrotic cell death. [GOC:aruk, GOC:rph, PMID:27258785]", "GOBP_NEGATIVE_REGULATION_OF_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION": "", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION": "", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_BINDING": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS_IN_THE_VACUOLE": "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]", "GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH": "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_DEPHOSPHORYLATION": "", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_K63_LINKED_UBIQUITINATION": "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_ACTIVITY_BY_REGULATION_OF_PROTEIN_PHOSPHORYLATION": "The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY": "", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMATIN": "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. [PMID:20889714, PMID:29899453]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION": "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MICROTUBULE": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS": "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. [GOC:mah, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_POLYUBIQUITINATION": "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_SUMOYLATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY": "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:BHF, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION": "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE": "Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY": "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_PROTEOLYSIS_INVOLVED_IN_PROTEIN_CATABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]", "GOBP_NEGATIVE_REGULATION_OF_PROTEIN_UBIQUITINATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]", "GOBP_NEGATIVE_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_PROTEOLYSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization. [GOC:hjd]", "GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING": "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. [GOC:signaling, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS": "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_RECYCLING": "Any process that stops, prevents, or reduces the rate of receptor recycling. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_SIGNALING_PATHWAY_VIA_JAK_STAT": "Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY": "Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]", "GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT": "Any process that stops, prevents or reduces the frequency, rate or extent of receptor signaling via STAT. [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]", "GOBP_NEGATIVE_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells. [ISBN:0781735149]", "GOBP_NEGATIVE_REGULATION_OF_RELAXATION_OF_MUSCLE": "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA": "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_RESPIRATORY_BURST": "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_RESPIRATORY_BURST_INVOLVED_IN_INFLAMMATORY_RESPONSE": "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS": "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS": "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_TYPE_II_INTERFERON": "Any process that decreases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. [GOC:dgh]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING": "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]", "GOBP_NEGATIVE_REGULATION_OF_RIG_I_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway. [GOC:bf, GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS": "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. [GOC:jid]", "GOBP_NEGATIVE_REGULATION_OF_RNA_CATABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. [GOC:bf, GOC:TermGenie, PMID:16640457]", "GOBP_NEGATIVE_REGULATION_OF_RUFFLE_ASSEMBLY": "Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly. [GOC:TermGenie, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_RNA_SPLICING": "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_SATELLITE_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]", "GOBP_NEGATIVE_REGULATION_OF_SCHWANN_CELL_PROLIFERATION": "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. [GOC:di, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE": "", "GOBP_NEGATIVE_REGULATION_OF_RNA_BIOSYNTHETIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. [GO:jl, GO_REF:0000058, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_SECRETION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_SIGNALING": "", "GOBP_NEGATIVE_REGULATION_OF_SIGNALING_RECEPTOR_ACTIVITY": "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_SINGLE_STRANDED_VIRAL_RNA_REPLICATION_VIA_DOUBLE_STRANDED_DNA_INTERMEDIATE": "Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND": "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_SISTER_CHROMATID_COHESION": "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR": "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION": "", "GOBP_NEGATIVE_REGULATION_OF_SMAD_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. [GOC:vw]", "GOBP_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. [CL:0000192, GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]", "GOBP_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT": "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]", "GOBP_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]", "GOBP_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]", "GOBP_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE": "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]", "GOBP_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT": "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE": "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]", "GOBP_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS": "Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958]", "GOBP_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_STEROID_HORMONE_BIOSYNTHETIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. [CL:0000737, GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING": "Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. [GOC:TermGenie, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_SYNAPSE_ASSEMBLY": "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]", "GOBP_NEGATIVE_REGULATION_OF_SYNAPSE_ORGANIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]", "GOBP_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC": "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION": "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]", "GOBP_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC": "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION": "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS": "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE": "The process that reduces the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]", "GOBP_NEGATIVE_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION": "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TELOMERE_CAPPING": "Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "GOBP_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE": "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE": "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TISSUE_REMODELING": "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING": "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "GOBP_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_NEGATIVE_REGULATION_OF_TORC1_SIGNALING": "Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]", "GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_I": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_COMPETITIVE_PROMOTER_BINDING": "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site. [GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_TOR_SIGNALING": "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING": "", "GOBP_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA1_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TRANSLATIONAL_ELONGATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II": "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]", "GOBP_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE": "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TRANSLATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:isa_complete]", "GOBP_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY": "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY": "Any process that stops or reduces the activity of a transporter. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS": "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. [GOC:rn, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS": "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. [GOC:BHF, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS": "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_TROPHOBLAST_CELL_MIGRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_TRANSPORT": "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_TUBULIN_DEACETYLATION": "", "GOBP_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY": "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION": "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]", "GOBP_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_TYPE_B_PANCREATIC_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]", "GOBP_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY": "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_TYPE_II_INTERFERON_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION": "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN": "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS": "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus. [GOC:add, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY": "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION": "", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY": "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_MIGRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE": "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]", "GOBP_NEGATIVE_REGULATION_OF_T_HELPER_17_TYPE_IMMUNE_RESPONSE": "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response. [GOC:BHF, GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process. [GOC:BHF]", "GOBP_NEGATIVE_REGULATION_OF_UBIQUITIN_PROTEIN_TRANSFERASE_ACTIVITY": "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. [GOC:ai, GOC:tb]", "GOBP_NEGATIVE_REGULATION_OF_URINE_VOLUME": "Any process that decreases the amount of urine excreted from the body over a unit of time. [GOC:mtg_25march11, GOC:yaf]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_MIGRATION": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. [GOC:dgh]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_CELL_PROLIFERATION": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_PERMEABILITY": "Any process that reduces the extent to which blood vessels can be pervaded by fluid. [GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION": "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production. [GO_REF:0000058, GOC:TermGenie, PMID:19404486]", "GOBP_NEGATIVE_REGULATION_OF_VASCULAR_WOUND_HEALING": "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:BHF, GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_VASOCONSTRICTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL": "", "GOBP_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT": "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. [GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION": "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. [GOC:go_curators]", "GOBP_NEGATIVE_REGULATION_OF_VIRAL_LIFE_CYCLE": "Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle. [GO_REF:0000058, GOC:TermGenie, PMID:18005716]", "GOBP_NEGATIVE_REGULATION_OF_VITAMIN_D_BIOSYNTHETIC_PROCESS": "", "GOBP_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION": "Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. [GOC:mah]", "GOBP_NEGATIVE_REGULATION_OF_VIRAL_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. [GOC:bf, GOC:jl]", "GOBP_NEGATIVE_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY": "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie]", "GOBP_NEGATIVE_REGULATION_OF_VITAMIN_METABOLIC_PROCESS": "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]", "GOBP_NEGATIVE_REGULATION_OF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY": "", "GOBP_NEGATIVE_REGULATION_OF_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS": "Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]", "GOBP_NEGATIVE_T_CELL_SELECTION": "The process of elimination of immature T cells which react strongly with self-antigens. [ISBN:0781735149, PMID:12414722]", "GOBP_NEPHRIC_DUCT_DEVELOPMENT": "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. [GOC:mtg_kidney_jan10]", "GOBP_NEGATIVE_REGULATION_OF_WOUND_HEALING": "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:dph]", "GOBP_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY": "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_NEPHRIC_DUCT_FORMATION": "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney. [GOC:mtg_kidney_jan10]", "GOBP_NEPHRIC_DUCT_MORPHOGENESIS": "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. [GOC:mtg_kidney_jan10]", "GOBP_NEPHRON_EPITHELIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. [GOC:mtg_kidney_jan10]", "GOBP_NEPHRON_DEVELOPMENT": "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. [GOC:mtg_kidney_jan10]", "GOBP_NEPHRON_TUBULE_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10]", "GOBP_NEPHRON_MORPHOGENESIS": "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney. [GOC:mtg_kidney_jan10]", "GOBP_NEPHRON_TUBULE_FORMATION": "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. [GOC:mtg_kidney_jan10]", "GOBP_NERVE_DEVELOPMENT": "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_NERVE_GROWTH_FACTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:11520933]", "GOBP_NERVOUS_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE": "The regulation of blood pressure mediated by detection of stimuli and a neurological response. [GOC:mtg_cardio, ISBN:0721643949]", "GOBP_NETRIN_ACTIVATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]", "GOBP_NEURAL_CREST_CELL_FATE_COMMITMENT": "The process in which a cell becomes committed to become a neural crest cell. [GOC:dh, GOC:ef]", "GOBP_NEURAL_CREST_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. [GOC:dh, GOC:ef]", "GOBP_NEURAL_CREST_FORMATION": "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. [GOC:dh, GOC:ef]", "GOBP_NEURAL_CREST_CELL_MIGRATION_INVOLVED_IN_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT": "Any neural crest cell migration that is involved in autonomic nervous system development. [GOC:BHF, GOC:TermGenie]", "GOBP_NERVOUS_SYSTEM_PROCESS": "An organ system process carried out by any of the organs or tissues of the neurological system. [GOC:ai, GOC:mtg_cardio]", "GOBP_NEURAL_FOLD_FORMATION": "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. [GOC:dph, ISBN:0878932437]", "GOBP_NEURAL_PLATE_MORPHOGENESIS": "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. [GOC:dph, ISBN:0878932437]", "GOBP_NEURAL_PLATE_PATTERN_SPECIFICATION": "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_NEURAL_PLATE_DEVELOPMENT": "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]", "GOBP_NEURAL_NUCLEUS_DEVELOPMENT": "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. [GO_REF:0000021]", "GOBP_NEURAL_PLATE_REGIONALIZATION": "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_NEURAL_RETINA_DEVELOPMENT": "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_NEURAL_TUBE_DEVELOPMENT": "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_NEURAL_PRECURSOR_CELL_PROLIFERATION": "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. [GOC:dph, GOC:yaf]", "GOBP_NEURAL_TUBE_FORMATION": "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. [GOC:dph, ISBN:0878932437]", "GOBP_NEUROBLAST_DIFFERENTIATION": "", "GOBP_NEURAL_TUBE_PATTERNING": "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_NEUROBLAST_MIGRATION": "", "GOBP_NEUROBLAST_DIVISION": "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. [PMID:11163136, PMID:11250167]", "GOBP_NEUROENDOCRINE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. [GOC:dph]", "GOBP_NEUROBLAST_PROLIFERATION": "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. [GOC:ai, GOC:mtg_sensu, GOC:sart]", "GOBP_NEUROFILAMENT_CYTOSKELETON_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins. [GOC:dph]", "GOBP_NEUROEPITHELIAL_CELL_DIFFERENTIATION": "The process in which epiblast cells acquire specialized features of neuroepithelial cells. [GOC:dph, GOC:tb]", "GOBP_NEUROINFLAMMATORY_RESPONSE": "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]", "GOBP_NEUROMUSCULAR_JUNCTION_DEVELOPMENT": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. [GOC:mtg_OBO2OWL_2013]", "GOBP_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE": "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. [GOC:dph, GOC:tb]", "GOBP_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE": "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. [GOC:ai, GOC:dph]", "GOBP_NEUROMUSCULAR_PROCESS": "Any process pertaining to the functions of the nervous and muscular systems of an organism. [GOC:ai]", "GOBP_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION": "The process of synaptic transmission from a neuron to a muscle, across a synapse. [GOC:dos, GOC:jl, MeSH:D009435]", "GOBP_NEURONAL_ACTION_POTENTIAL_PROPAGATION": "", "GOBP_NEURONAL_DENSE_CORE_VESICLE_EXOCYTOSIS": "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels. [GOC:kmv, PMID:17553987, PMID:24653208]", "GOBP_NEURONAL_ACTION_POTENTIAL": "An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb]", "GOBP_NEURONAL_ION_CHANNEL_CLUSTERING": "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. [PMID:11456440]", "GOBP_NEUROGENESIS": "Generation of cells within the nervous system. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_NEURONAL_SIGNAL_TRANSDUCTION": "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular. [GOC:mtg_signal]", "GOBP_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE": "Any process in by an organism or tissue maintains a population of neuronal stem cells. [CL:0000047, GOC:dos, GOC:yaf, PMID:11399758]", "GOBP_NEURON_CELL_CELL_ADHESION": "The attachment of a neuron to another cell via adhesion molecules. [GOC:go_curators]", "GOBP_NEURON_CELLULAR_HOMEOSTASIS": "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. [GOC:BHF, GOC:mah]", "GOBP_NEURON_FATE_DETERMINATION": "The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:dph]", "GOBP_NEURON_APOPTOTIC_PROCESS": "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis]", "GOBP_NEURON_FATE_COMMITMENT": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. [GOC:dph]", "GOBP_NEURON_FATE_SPECIFICATION": "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. [GOC:dph]", "GOBP_NEURON_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OXIDATIVE_STRESS": "The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. [GOC:bf, GOC:PARL, PMID:23858059]", "GOBP_NEURON_GLIAL_CELL_SIGNALING": "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368]", "GOBP_NEURON_DEVELOPMENT": "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dph]", "GOBP_NEURON_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. [GOC:dph, GOC:jl]", "GOBP_NEURON_NEURON_SYNAPTIC_TRANSMISSION": "The process of synaptic transmission from a neuron to another neuron across a synapse. [GOC:add, GOC:dos, GOC:jl, MeSH:D009435]", "GOBP_NEURON_MIGRATION": "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. [CL:0000540, GOC:go_curators]", "GOBP_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE": "Any neuron projection extension that is involved in neuron projection guidance. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]", "GOBP_NEURON_PROJECTION_ARBORIZATION": "The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites. [GOC:aruk, GOC:bc, PMID:17114044, PMID:23270857, PMID:23764288]", "GOBP_NEURON_PROJECTION_MAINTENANCE": "The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:kmv, PMID:25359212]", "GOBP_NEURON_PROJECTION_EXTENSION": "Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:BHF, GOC:rl, PMID:22790009]", "GOBP_NEURON_PROJECTION_GUIDANCE": "The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:rl, PMID:22790009]", "GOBP_NEURON_PROJECTION_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. [GOC:aruk, GOC:bc, PMID:11585923]", "GOBP_NEURON_REMODELING": "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. [GOC:hb]", "GOBP_NEURON_PROJECTION_REGENERATION": "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. [GOC:dgh, GOC:dph, GOC:tb]", "GOBP_NEURON_RECOGNITION": "The process in which a neuronal cell in a multicellular organism interprets its surroundings. [GOC:go_curators]", "GOBP_NEUROTRANSMITTER_GATED_ION_CHANNEL_CLUSTERING": "The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane. [GOC:dsf, PMID:20843816]", "GOBP_NEUROTRANSMITTER_LOADING_INTO_SYNAPTIC_VESICLE": "The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps. [GOC:bf, GOC:pad, GOC:PARL, PMID:10099709, PMID:15217342]", "GOBP_NEUROPEPTIDE_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]", "GOBP_NEUROTRANSMITTER_RECEPTOR_INTERNALIZATION": "", "GOBP_NEUROTRANSMITTER_RECEPTOR_TRANSPORT": "The directed movement of neurotransmitter receptors. [GOC:dos]", "GOBP_NEUROTRANSMITTER_RECEPTOR_TRANSPORT_ENDOSOME_TO_POSTSYNAPTIC_MEMBRANE": "The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. [GOC:dos]", "GOBP_NEUROTRANSMITTER_RECEPTOR_LOCALIZATION_TO_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE": "A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). [GOC:dos]", "GOBP_NEUROTRANSMITTER_RECEPTOR_TRANSPORT_POSTSYNAPTIC_ENDOSOME_TO_LYSOSOME": "", "GOBP_NEUROTRANSMITTER_REUPTAKE": "The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol. [GOC:dos]", "GOBP_NEUROTRANSMITTER_RECEPTOR_TRANSPORT_TO_PLASMA_MEMBRANE": "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles. [GOC:dos]", "GOBP_NEUROTRANSMITTER_TRANSPORT": "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai]", "GOBP_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor]", "GOBP_NEUROTRANSMITTER_SECRETION": "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. [GOC:dph]", "GOBP_NEUROTRANSMITTER_UPTAKE": "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]", "GOBP_NEUROTROPHIN_SIGNALING_PATHWAY": "The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, Wikipedia:Neurotrophin]", "GOBP_NEUTRAL_AMINO_ACID_TRANSPORT": "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. [GOC:ai]", "GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. [GOC:ai]", "GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. [ISBN:0198547684]", "GOBP_NEUTROPHIL_DEGRANULATION": "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil. [ISBN:0781735149]", "GOBP_NEUTROPHIL_APOPTOTIC_PROCESS": "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266]", "GOBP_NEUTROPHIL_DIFFERENTIATION": "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil. [GOC:mah]", "GOBP_NEUTROPHIL_CHEMOTAXIS": "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732]", "GOBP_NEUTROPHIL_HOMEOSTASIS": "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, GOC:pr, PMID:12752675, PMID:12960266]", "GOBP_NEUTROPHIL_EXTRAVASATION": "The migration of a neutrophil from the blood vessels into the surrounding tissue. [CL:0000775, GOC:BHF]", "GOBP_NEUTROPHIL_CLEARANCE": "The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms. [GOC:BHF, PMID:21957127]", "GOBP_NEUTROPHIL_MEDIATED_CYTOTOXICITY": "The directed killing of a target cell by a neutrophil. [GOC:add, ISBN:0781765196]", "GOBP_NEUTROPHIL_MEDIATED_KILLING_OF_GRAM_NEGATIVE_BACTERIUM": "The directed killing of a gram-negative bacterium by a neutrophil. [GOC:add, ISBN:0781765196]", "GOBP_NEUTROPHIL_MEDIATED_IMMUNITY": "Any process involved in the carrying out of an immune response by a neutrophil. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_NEUTROPHIL_MEDIATED_KILLING_OF_SYMBIONT_CELL": "", "GOBP_NEUTROPHIL_MIGRATION": "The movement of a neutrophil within or between different tissues and organs of the body. [PMID:1826836]", "GOBP_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. [GOC:jl, PMID:21549190]", "GOBP_NITROGEN_CYCLE_METABOLIC_PROCESS": "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle]", "GOBP_NITRIC_OXIDE_TRANSPORT": "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_NITRIC_OXIDE_CGMP_MEDIATED_SIGNALING": "An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP. [GOC:signaling, PMID:21549190, PMID:22019632]", "GOBP_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS": "", "GOBP_NK_T_CELL_ACTIVATION": "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [ISBN:0781735149, PMID:12154375, PMID:9133426]", "GOBP_NITROGEN_UTILIZATION": "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. [GOC:mah, GOC:mlg]", "GOBP_NK_T_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of a NK T cell. [GOC:add, ISBN:0781735149, PMID:10704459]", "GOBP_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS": "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope. [GOC:ai]", "GOBP_NK_T_CELL_PROLIFERATION": "The expansion of a NK T cell population by cell division. [GOC:add, ISBN:0781735149, PMID:10704459]", "GOBP_NONASSOCIATIVE_LEARNING": "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment. [ISBN:0582227089]", "GOBP_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS": "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. [ISBN:0198506732]", "GOBP_NITROGEN_COMPOUND_TRANSPORT": "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_NON_LYTIC_VIRAL_RELEASE": "The exit of a viral particle from a host cell that does not involve cell lysis. [GOC:bf, GOC:jl, ISBN:0072370319]", "GOBP_NODAL_SIGNALING_PATHWAY": "The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:vk, PMID:17287255]", "GOBP_NON_MEMBRANE_BOUNDED_ORGANELLE_ASSEMBLY": "", "GOBP_NON_CANONICAL_WNT_SIGNALING_PATHWAY": "A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin. [PMID:37804416]", "GOBP_NON_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]", "GOBP_NON_PROTEINOGENIC_AMINO_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids. [GOC:ew]", "GOBP_NON_MOTILE_CILIUM_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium. [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]", "GOBP_NON_PROTEINOGENIC_AMINO_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids. [GOC:ew]", "GOBP_NORADRENERGIC_NEURON_DEVELOPMENT": "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dph]", "GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving non-proteingenic amino acids. [GOC:ew]", "GOBP_NOREPINEPHRINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. [GOC:jl, ISBN:0198506732]", "GOBP_NORADRENERGIC_NEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline. [GOC:dph]", "GOBP_NOREPINEPHRINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. [GOC:jl, ISBN:0198506732]", "GOBP_NOREPINEPHRINE_UPTAKE": "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. [GOC:ai]", "GOBP_NOREPINEPHRINE_SECRETION": "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. [GOC:ef, GOC:jid]", "GOBP_NOREPINEPHRINE_TRANSPORT": "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. [GOC:ai, ISBN:0198506732]", "GOBP_NOSE_DEVELOPMENT": "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). [GOC:jl]", "GOBP_NOTCH_RECEPTOR_PROCESSING": "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. [PMID:12651094, PMID:14986688]", "GOBP_NOTOCHORD_DEVELOPMENT": "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. [GOC:dgh]", "GOBP_NOTOCHORD_MORPHOGENESIS": "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. [GOC:jid]", "GOBP_NOTCH_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:go_curators, GOC:signaling]", "GOBP_NUCLEAR_BODY_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_NUCLEAR_MEMBRANE_REASSEMBLY": "The reformation of the nuclear membranes following their breakdown in the context of a normal process. [GOC:mah]", "GOBP_NUCLEAR_ENVELOPE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. [GOC:dph, GOC:ems, GOC:jl, GOC:mah]", "GOBP_NUCLEAR_MEMBRANE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. [GOC:mah]", "GOBP_NUCLEAR_MIGRATION": "", "GOBP_NUCLEAR_CHROMOSOME_SEGREGATION": "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. [GOC:dos]", "GOBP_NUCLEAR_EXPORT": "The directed movement of substances out of the nucleus. [GOC:ai]", "GOBP_NUCLEAR_MIGRATION_ALONG_MICROTUBULE": "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. [GOC:mah, GOC:sgd_curators]", "GOBP_NUCLEAR_PORE_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. [GOC:ai, GOC:mah]", "GOBP_NUCLEAR_MRNA_SURVEILLANCE": "A process that identifies and degrades defective or aberrant mRNAs within the nucleus. [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728, PMID:14718167, PMID:18644474]", "GOBP_NUCLEAR_PORE_LOCALIZATION": "Any process in which nuclear pores are transported to, or maintained in, a specific location. [GOC:ai]", "GOBP_NUCLEAR_PORE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. [GOC:dph, GOC:jid, GOC:jl, GOC:mah]", "GOBP_NUCLEAR_RNA_SURVEILLANCE": "", "GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_INDEPENDENT_DECAY": "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability. [GOC:krc, PMID:15225542, PMID:15225544]", "GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY": "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. [GOC:jp, GOC:krc]", "GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. [GOC:krc]", "GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY": "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. [GOC:krc, GOC:ma, PMID:10025395]", "GOBP_NUCLEOBASE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. [GOC:ai]", "GOBP_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING": "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. [GOC:krc]", "GOBP_NUCLEOBASE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. [GOC:ai]", "GOBP_NUCLEAR_TRANSPORT": "The directed movement of substances into, out of, or within the nucleus. [GOC:ai]", "GOBP_NUCLEIC_ACID_CATABOLIC_PROCESS": "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid. [GOC:curators]", "GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. [GOC:mah]", "GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION": "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. [GOC:mah, ISBN:0306444747, ISBN:0471394831]", "GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS": "", "GOBP_NUCLEOBASE_TRANSPORT": "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732]", "GOBP_NUCLEOLAR_CHROMATIN_ORGANIZATION": "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin. [PMID:18362178]", "GOBP_NUCLEOBASE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. [GOC:ma]", "GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT": "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_NUCLEOLUS_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. [GOC:dph, GOC:jid, GOC:jl, GOC:mah]", "GOBP_NUCLEOLAR_LARGE_RRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_I": "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I. [GOC:jl, GOC:txnOH, ISBN:0321000382]", "GOBP_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS": "", "GOBP_NUCLEOPHAGY": "A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. [GOC:autophagy, GOC:jl, PMID:24013549]", "GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS": "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. [GOC:vw]", "GOBP_NUCLEOSIDE_BISPHOSPHATE_CATABOLIC_PROCESS": "", "GOBP_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS": "", "GOBP_NUCLEOSIDE_DIPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOSIDE_DIPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). [GOC:ma]", "GOBP_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOSIDE_MONOPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOSIDE_MONOPHOSPHATE_PHOSPHORYLATION": "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside. [GOC:ai]", "GOBP_NUCLEOSIDE_SALVAGE": "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. [GOC:jl]", "GOBP_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT": "The directed movement of nucleoside across a membrane. [GOC:pr, GOC:TermGenie]", "GOBP_NUCLEOSIDE_TRANSPORT": "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. [GOC:TermGenie]", "GOBP_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. [GOC:TermGenie]", "GOBP_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOTIDE_BINDING_OLIGOMERIZATION_DOMAIN_CONTAINING_2_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process. [GOC:add, PMID:17944960, PMID:18585455]", "GOBP_NUCLEOTIDE_BINDING_OLIGOMERIZATION_DOMAIN_CONTAINING_1_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process. [GOC:add, PMID:17944960, PMID:18585455]", "GOBP_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. [GOC:sj, PMID:18280719, PMID:32838963, PMID:36973360]", "GOBP_NUCLEOSOME_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. [GOC:mah]", "GOBP_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING": "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. [ISBN:0815316194]", "GOBP_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_NUCLEOTIDE_EXCISION_REPAIR": "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). [PMID:10197977]", "GOBP_NUCLEOTIDE_SALVAGE": "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. [GOC:jl]", "GOBP_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ISBN:0198506732]", "GOBP_NUCLEOTIDE_SUGAR_TRANSMEMBRANE_TRANSPORT": "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ISBN:0198506732]", "GOBP_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT": "The directed movement of nucleotide across a membrane. [GOC:pr, GOC:TermGenie]", "GOBP_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS": "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ISBN:0198506732]", "GOBP_NUCLEUS_LOCALIZATION": "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]", "GOBP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. [ISBN:0198506732]", "GOBP_N_ACETYLNEURAMINATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. [ISBN:0198506732]", "GOBP_NUCLEOTIDE_TRANSPORT": "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. [ISBN:0198506732]", "GOBP_N_ACETYLNEURAMINATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. [ISBN:0198506732]", "GOBP_N_ACYLETHANOLAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group. [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693]", "GOBP_NUCLEUS_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. [GOC:dph, GOC:ems, GOC:jl, GOC:mah]", "GOBP_N_GLYCAN_PROCESSING": "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. [PMID:12736198, PMID:35536965]", "GOBP_N_ACYLPHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group. [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693]", "GOBP_N_TERMINAL_PEPTIDYL_METHIONINE_ACETYLATION": "", "GOBP_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION": "The acetylation of the N-terminal amino acid of proteins. [GOC:ai]", "GOBP_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION": "The alteration of the N-terminal amino acid residue in a protein. [GOC:mah]", "GOBP_OBSERVATIONAL_LEARNING": "Learning that occurs through observing the behavior of others. [GOC:dos, Wikipedia:Observational_learning&oldid=603524137]", "GOBP_N_TERMINAL_PROTEIN_LIPIDATION": "The covalent attachment of a lipid group to the amino terminus of a protein. [GOC:jl]", "GOBP_ODONTOBLAST_DIFFERENTIATION": "The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin. [GOC:sl, PMID:20425127]", "GOBP_ODONTOGENESIS": "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. [GOC:jl, GOC:mah]", "GOBP_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH": "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]", "GOBP_OLFACTORY_BEHAVIOR": "The behavior of an organism in response to an odor. [GOC:jid, GOC:pr]", "GOBP_OLEFINIC_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). [GOC:krc]", "GOBP_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT": "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION": "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C). [GOC:krc]", "GOBP_OLFACTORY_NERVE_DEVELOPMENT": "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_OLIGODENDROCYTE_APOPTOTIC_PROCESS": "", "GOBP_OLFACTORY_LOBE_DEVELOPMENT": "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_OLIGOPEPTIDE_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol. [PMID:22226946]", "GOBP_OLIGODENDROCYTE_PROGENITOR_PROLIFERATION": "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system. [GOC:mah, GOC:sl, PMID:15504915]", "GOBP_OLIGODENDROCYTE_DEVELOPMENT": "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. [GOC:dgh, GOC:ef]", "GOBP_OLIGODENDROCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. [GOC:vp, PMID:15139015]", "GOBP_OLIGOPEPTIDE_TRANSPORT": "The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [ISBN:0198506732]", "GOBP_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]", "GOBP_OLIGOSACCHARIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]", "GOBP_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS": "", "GOBP_OMEGA_HYDROXYLASE_P450_PATHWAY": "The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. [GOC:mw, PMID:10681399]", "GOBP_OLIGOSACCHARIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]", "GOBP_ONE_CARBON_METABOLIC_PROCESS": "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde]", "GOBP_ONE_CARBON_COMPOUND_TRANSPORT": "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_OOCYTE_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION": "", "GOBP_OOCYTE_CONSTRUCTION": "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732]", "GOBP_ONCOGENE_INDUCED_CELL_SENESCENCE": "A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family. [GOC:BHF]", "GOBP_OOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. [GOC:go_curators, GOC:mtg_sensu]", "GOBP_OPTIC_CUP_MORPHOGENESIS_INVOLVED_IN_CAMERA_TYPE_EYE_DEVELOPMENT": "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]", "GOBP_OPSONIZATION": "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149]", "GOBP_OOGENESIS": "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. [GOC:kmv, GOC:mtg_sensu, GOC:pr]", "GOBP_OOCYTE_MATURATION": "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "GOBP_OPTIC_NERVE_MORPHOGENESIS": "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_OPTIC_NERVE_DEVELOPMENT": "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_ORGANELLE_DISASSEMBLY": "The disaggregation of an organelle into its constituent components. [GO_REF:0000079, GOC:TermGenie]", "GOBP_ORGANELLE_INHERITANCE": "The partitioning of organelles between daughter cells at cell division. [GOC:jid]", "GOBP_ORGANELLE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:mah]", "GOBP_ORGANELLE_FUSION": "The creation of a single organelle from two or more organelles. [GOC:jid]", "GOBP_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE": "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. [GOC:mah]", "GOBP_ORGANELLE_FISSION": "The creation of two or more organelles by division of one organelle. [GOC:jid]", "GOBP_ORGANELLE_MEMBRANE_FUSION": "The joining of two lipid bilayers to form a single organelle membrane. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_ORGANELLE_LOCALIZATION": "Any process in which an organelle is transported to, and/or maintained in, a specific location. [GOC:ai]", "GOBP_ORGANIC_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. [ISBN:0198506732]", "GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT": "", "GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. [ISBN:0198506732]", "GOBP_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS": "", "GOBP_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS": "", "GOBP_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS": "", "GOBP_ORGANIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. [ISBN:0198506732]", "GOBP_ORGANIC_CATION_TRANSPORT": "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. [GOC:ai]", "GOBP_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS": "", "GOBP_ORGANIC_ANION_TRANSPORT": "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc]", "GOBP_ORGANIC_ACID_TRANSPORT": "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732]", "GOBP_ORGANISM_EMERGENCE_FROM_PROTECTIVE_STRUCTURE": "The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case. [GOC:mah]", "GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT": "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. [GOC:ai]", "GOBP_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS": "", "GOBP_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS": "", "GOBP_ORGAN_INDUCTION": "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. [ISBN:0878932437]", "GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT": "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. [GOC:mcc]", "GOBP_ORGANOPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. [GOC:ai]", "GOBP_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE": "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. [GO_REF:0000022, GOC:jal]", "GOBP_ORNITHINE_TRANSPORT": "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. [GOC:chem_mtg]", "GOBP_ORGAN_GROWTH": "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. [GOC:bf, ISBN:0471245208, ISBN:0721662544]", "GOBP_ORNITHINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. [GOC:jl, ISBN:0192801023]", "GOBP_OSMOSENSORY_SIGNALING_PATHWAY": "The series of molecular signals initiated in response to osmotic change. [GOC:jl]", "GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. [ISBN:0198506732]", "GOBP_OSTEOBLAST_DEVELOPMENT": "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. [GOC:dph]", "GOBP_OSTEOBLAST_PROLIFERATION": "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. [GOC:mah]", "GOBP_OSTEOCLAST_PROLIFERATION": "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. [CL:0000092, GOC:hjd]", "GOBP_OTIC_VESICLE_DEVELOPMENT": "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. [GOC:mah]", "GOBP_OSTEOBLAST_DIFFERENTIATION": "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid]", "GOBP_OSTEOCLAST_FUSION": "The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast. [CL:0000092, CL:0000779, GOC:BHF, GOC:mah, PMID:12713016]", "GOBP_OTIC_VESICLE_FORMATION": "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear. [GOC:dgh]", "GOBP_OSTEOCLAST_DIFFERENTIATION": "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]", "GOBP_OSSIFICATION": "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:mtg_mpo, PMID:17572649]", "GOBP_OTIC_VESICLE_MORPHOGENESIS": "The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. [GOC:mah]", "GOBP_OTOLITH_DEVELOPMENT": "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure. [GOC:sr]", "GOBP_OUTER_DYNEIN_ARM_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. [GOC:BHF, GOC:vk, PMID:19944400]", "GOBP_OTOLITH_MORPHOGENESIS": "The process in which the anatomical structures of an otolith are generated and organized. [GOC:dgh]", "GOBP_OVARIAN_FOLLICLE_DEVELOPMENT": "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "GOBP_OVIDUCT_DEVELOPMENT": "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. [GOC:dph, GOC:ebc, PMID:22918811, PMID:27875265]", "GOBP_OVULATION_CYCLE_PROCESS": "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. [GOC:isa_complete]", "GOBP_OVULATION_CYCLE": "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. [ISBN:0721662544]", "GOBP_OVULATION": "The release of a mature ovum/oocyte from an ovary. [GOC:bf, ISBN:0878932437]", "GOBP_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS": "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. [GOC:mtg_heart]", "GOBP_OXALATE_TRANSPORT": "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. [ISBN:0198506732]", "GOBP_OVULATION_FROM_OVARIAN_FOLLICLE": "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus. [GOC:mtg_sensu, https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "GOBP_OUTER_EAR_MORPHOGENESIS": "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull. [GOC:jl, ISBN:0192801023]", "GOBP_OUTFLOW_TRACT_MORPHOGENESIS": "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_heart, UBERON:0004145]", "GOBP_OXIDATIVE_DEMETHYLATION": "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. [GOC:BHF, GOC:mah, GOC:rl]", "GOBP_OXALOACETATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. [ISBN:0198506732]", "GOBP_OXYGEN_METABOLIC_PROCESS": "The chemical reactions and pathways involving diatomic oxygen (O2). [GOC:mah]", "GOBP_OXIDATIVE_PHOSPHORYLATION": "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. [ISBN:0198506732, ISBN:0471331309]", "GOBP_O_GLYCAN_PROCESSING": "", "GOBP_OXYGEN_TRANSPORT": "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_PANCREATIC_A_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. [GOC:dph, PMID:11076772]", "GOBP_P38MAPK_CASCADE": "A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. [PMID:20811974, PMID:23125017, PMID:32794416]", "GOBP_PALLIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_PANTOTHENATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. [GOC:ai, ISBN:0721662544]", "GOBP_PANCREATIC_JUICE_SECRETION": "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. [GOC:mah, ISBN:0198506732]", "GOBP_PANCREAS_DEVELOPMENT": "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. [GOC:cvs]", "GOBP_PARACRINE_SIGNALING": "The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other. [GOC:mtg_signaling_feb11, ISBN:3527303782]", "GOBP_PARALLEL_ACTIN_FILAMENT_BUNDLE_ASSEMBLY": "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity. [GOC:mah, ISBN:0815316194]", "GOBP_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. [FMA:9907, GOC:jid, GOC:sr]", "GOBP_PARANODAL_JUNCTION_ASSEMBLY": "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier. [PMID:14715942]", "GOBP_PARAXIAL_MESODERM_DEVELOPMENT": "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. [GOC:dgh]", "GOBP_PARATHYROID_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone. [GOC:dph, ISBN:0721662544]", "GOBP_PARAXIAL_MESODERM_MORPHOGENESIS": "The process in which the anatomical structures of the paraxial mesoderm are generated and organized. [GOC:go_curators]", "GOBP_PARENTAL_BEHAVIOR": "A reproductive behavior in which a parent cares for and rears offspring. [GOC:dph]", "GOBP_PARAXIAL_MESODERM_FORMATION": "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:dgh]", "GOBP_PARKIN_MEDIATED_STIMULATION_OF_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION": "", "GOBP_PARTURITION": "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. [ISBN:0198506732]", "GOBP_PATTERN_SPECIFICATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate. [GOC:dph, GOC:mtg_kidney_jan10]", "GOBP_PENETRATION_OF_ZONA_PELLUCIDA": "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. [GOC:jl, PMID:21755679]", "GOBP_PENTOSE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. [ISBN:0198506732]", "GOBP_PENILE_ERECTION": "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. [GOC:jl, Wikipedia:Penile_erection]", "GOBP_PEPTIDE_ANTIGEN_ASSEMBLY_WITH_MHC_CLASS_II_PROTEIN_COMPLEX": "The binding of a peptide to the antigen binding groove of an MHC class II protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]", "GOBP_PENTOSE_PHOSPHATE_SHUNT_NON_OXIDATIVE_BRANCH": "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]", "GOBP_PEPTIDE_ANTIGEN_ASSEMBLY_WITH_MHC_CLASS_I_PROTEIN_COMPLEX": "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591]", "GOBP_PEPTIDE_ANTIGEN_ASSEMBLY_WITH_MHC_PROTEIN_COMPLEX": "The binding of a peptide to the antigen binding groove of an MHC protein complex. [GOC:add, ISBN:0781735149, PMID:15771591]", "GOBP_PATTERN_SPECIFICATION_PROCESS": "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]", "GOBP_PEPTIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:jl]", "GOBP_PEPTIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. [GOC:dph, GOC:jl]", "GOBP_PEPTIDE_CROSS_LINKING": "The formation of a covalent cross-link between or within protein chains. [GOC:jsg]", "GOBP_PEPTIDE_MODIFICATION": "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide. [GOC:mah]", "GOBP_PEPTIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:go_curators]", "GOBP_PEPTIDOGLYCAN_METABOLIC_PROCESS": "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. [PMID:33139480]", "GOBP_PEPTIDYL_ARGININE_METHYLATION": "The addition of a methyl group to an arginine residue in a protein. [GOC:mah]", "GOBP_PEPTIDYL_ARGININE_METHYLATION_TO_ASYMMETRICAL_DIMETHYL_ARGININE": "", "GOBP_PEPTIDE_TRANSPORT": "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_PEPTIDYL_CYSTEINE_MODIFICATION": "The modification of peptidyl-cysteine. [GOC:go_curators]", "GOBP_PEPTIDYL_ARGININE_MODIFICATION": "The modification of peptidyl-arginine. [GOC:go_curators]", "GOBP_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION": "The modification of peptidyl-glutamic acid. [GOC:go_curators]", "GOBP_PEPTIDYL_HISTIDINE_MODIFICATION": "The modification of peptidyl-histidine. [GOC:ma]", "GOBP_PEPTIDYL_AMINO_ACID_MODIFICATION": "The alteration of an amino acid residue in a peptide. [GOC:mah]", "GOBP_PEPTIDYL_LYSINE_ACETYLATION": "The acetylation of peptidyl-lysine. [GOC:mah]", "GOBP_PEPTIDYL_LYSINE_DEACETYLATION": "", "GOBP_PEPTIDYL_LYSINE_DIMETHYLATION": "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. [RESID:AA0075]", "GOBP_PEPTIDYL_LYSINE_HYDROXYLATION": "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine. [GOC:ai]", "GOBP_PEPTIDYL_LYSINE_MODIFICATION": "The modification of peptidyl-lysine. [GOC:go_curators]", "GOBP_PEPTIDYL_LYSINE_TRIMETHYLATION": "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. [RESID:AA0074]", "GOBP_PEPTIDYL_L_CYSTEINE_S_PALMITOYLATION": "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine. [RESID:AA0106]", "GOBP_PEPTIDYL_LYSINE_MONOMETHYLATION": "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. [RESID:AA0076]", "GOBP_PEPTIDYL_LYSINE_OXIDATION": "", "GOBP_PEPTIDYL_LYSINE_METHYLATION": "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. [GOC:ai]", "GOBP_PEPTIDYL_PROLINE_HYDROXYLATION": "", "GOBP_PEPTIDYL_METHIONINE_MODIFICATION": "", "GOBP_PEPTIDYL_PROLINE_MODIFICATION": "The modification of peptidyl-proline. [GOC:go_curators]", "GOBP_PEPTIDYL_PROLINE_HYDROXYLATION_TO_4_HYDROXY_L_PROLINE": "", "GOBP_PEPTIDYL_SERINE_AUTOPHOSPHORYLATION": "The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein. [GOC:pm]", "GOBP_PEPTIDYL_SERINE_DEPHOSPHORYLATION": "", "GOBP_PEPTIDYL_SERINE_MODIFICATION": "The modification of peptidyl-serine. [GOC:go_curators]", "GOBP_PEPTIDYL_THREONINE_DEPHOSPHORYLATION": "The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. [GOC:bf]", "GOBP_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION": "The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. [PMID:10037737, PMID:10068444, PMID:10940390]", "GOBP_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION_INVOLVED_IN_INACTIVATION_OF_PROTEIN_KINASE_ACTIVITY": "", "GOBP_PEPTIDYL_THREONINE_MODIFICATION": "", "GOBP_PERICARDIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438]", "GOBP_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION": "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf]", "GOBP_PEPTIDYL_TYROSINE_MODIFICATION": "The modification of peptidyl-tyrosine. [GOC:go_curators]", "GOBP_PERICARDIUM_MORPHOGENESIS": "The process in which the anatomical structure of the pericardium is generated and organized. [GOC:dph, PMID:18722343]", "GOBP_PERICENTRIC_HETEROCHROMATIN_FORMATION": "", "GOBP_PERIPHERAL_NERVOUS_SYSTEM_AXON_REGENERATION": "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury. [GOC:ef]", "GOBP_PERICYTE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830]", "GOBP_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT": "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. [GOC:dgh]", "GOBP_PERIPHERAL_NERVOUS_SYSTEM_MYELIN_MAINTENANCE": "The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state. [GOC:dgh]", "GOBP_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. [GOC:go_curators, UBERON:0000010]", "GOBP_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. [GOC:dgh]", "GOBP_PEROXISOMAL_TRANSPORT": "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. [GOC:jl]", "GOBP_PERISTALSIS": "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. [ISBN:0198506732]", "GOBP_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE": "The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. [GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041]", "GOBP_PEROXISOME_FISSION": "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. [GOC:mah, PMID:11687502, PMID:14754507]", "GOBP_PEXOPHAGY": "", "GOBP_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY": "A nuclear receptor-mediated signaling pathway initiated by a ligand binding to an intracellular peroxisome proliferator activated receptor (alpha, beta or gamma) of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription. [PMID:18221086]", "GOBP_PEROXISOME_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. [GOC:mah]", "GOBP_PHAGOCYTOSIS_ENGULFMENT": "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. [GOC:curators, ISBN:0781735149]", "GOBP_PHAGOLYSOSOME_ASSEMBLY": "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. [GOC:add, ISBN:0781735149]", "GOBP_PHAGOSOME_ACIDIFICATION": "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. [GOC:kmv, GOC:tb]", "GOBP_PHAGOCYTOSIS_RECOGNITION": "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. [GOC:curators, ISBN:0781735149]", "GOBP_PHAGOCYTOSIS": "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. [ISBN:0198506732]", "GOBP_PHAGOSOME_LYSOSOME_FUSION": "The creation of a phagolysosome from a phagosome and a lysosome. [GOC:kmv, GOC:tb]", "GOBP_PHAGOSOME_MATURATION": "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. [GOC:kmv, GOC:tb]", "GOBP_PHARYNGEAL_ARCH_ARTERY_MORPHOGENESIS": "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. [GOC:BHF, GOC:dph, PMID:20122914]", "GOBP_PHARYNGEAL_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. [GOC:dph]", "GOBP_PHASIC_SMOOTH_MUSCLE_CONTRACTION": "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. [GOC:mtg_muscle]", "GOBP_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. [GOC:ai]", "GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. [ISBN:0198506732]", "GOBP_PHENOL_CONTAINING_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. [ISBN:0198506732]", "GOBP_PHENYLPROPANOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. [GOC:jl]", "GOBP_PHENOTYPIC_SWITCHING": "A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues. [GOC:bf, GOC:di, PMID:12443899, PMID:22406749, PMID:8456504, Wikipedia:Phenotypic_switching]", "GOBP_PHOSPHAGEN_METABOLIC_PROCESS": "", "GOBP_PHOSPHATE_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. [GOC:jid, GOC:mah]", "GOBP_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORT": "The process in which a phosphate is transported across a membrane. [GOC:vw]", "GOBP_PHOSPHATE_ION_TRANSPORT": "The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING": "Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18195019, PMID:18458083]", "GOBP_PHOSPHATIDIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLCHOLINE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:jp]", "GOBP_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. [GOC:curators, ISBN:0198506732]", "GOBP_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING": "Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18287005, PMID:18458083]", "GOBP_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING": "Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. [GOC:mw, PMID:15485873, PMID:18458083]", "GOBP_PHOSPHATIDYLGLYCEROL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS": "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. [GOC:al, GOC:vw]", "GOBP_PHOSPHATIDYLINOSITOL_ACYL_CHAIN_REMODELING": "Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains. [GOC:mw, PMID:18094042, PMID:18772128]", "GOBP_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION": "The process of removing one or more phosphate groups from a phosphatidylinositol. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLINOSITOL_3_KINASE_PROTEIN_KINASE_B_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway. [PMID:20517722, PMID:22952397]", "GOBP_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING": "Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18287005, PMID:18458083]", "GOBP_PHOSPHATIDYLINOSITOL_MEDIATED_SIGNALING": "The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, GOC:ceb, ISBN:0198506732]", "GOBP_PHOSPHATIDYLINOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLSERINE_EXPOSURE_ON_APOPTOTIC_CELL_SURFACE": "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity. [GOC:mah, GOC:mtg_apoptosis, GOC:rk, PMID:11536005]", "GOBP_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]", "GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. [ISBN:0198506732]", "GOBP_PHOSPHOLIPASE_C_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY": "A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914]", "GOBP_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY": "A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]", "GOBP_PHOSPHOLIPID_DEPHOSPHORYLATION": "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. [ISBN:0198506732]", "GOBP_PHOSPHOLIPID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]", "GOBP_PHOSPHOLIPID_EFFLUX": "The directed movement of a phospholipid out of a cell or organelle. [GOC:mah]", "GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]", "GOBP_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]", "GOBP_PHOSPHOLIPID_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell. [GOC:BHF, GOC:rl]", "GOBP_PHOTOPERIODISM": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]", "GOBP_PHOSPHOLIPID_TRANSPORT": "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. [GOC:ai]", "GOBP_PHOSPHOLIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]", "GOBP_PHOTORECEPTOR_CELL_MORPHOGENESIS": "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. [GOC:jid, GOC:mah]", "GOBP_PHOTORECEPTOR_CELL_DIFFERENTIATION": "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. [GOC:ai, ISBN:0198506732]", "GOBP_PHOTORECEPTOR_CELL_OUTER_SEGMENT_ORGANIZATION": "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials. [ISBN:0824072820, PMID:14507858]", "GOBP_PHOTORECEPTOR_CELL_DEVELOPMENT": "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. [GOC:go_curators]", "GOBP_PHOTORECEPTOR_CELL_MAINTENANCE": "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. [CL:0000210, GOC:bf, GOC:rl]", "GOBP_PHOSPHORYLATION": "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732]", "GOBP_PHOTOTRANSDUCTION": "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. [GOC:go_curators]", "GOBP_PHOTOTRANSDUCTION_VISIBLE_LIGHT": "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. [GOC:go_curators, ISBN:0198506732]", "GOBP_PHYSIOLOGICAL_CARDIAC_MUSCLE_HYPERTROPHY": "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]", "GOBP_PH_REDUCTION": "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. [GOC:go_curators]", "GOBP_PIECEMEAL_MICROAUTOPHAGY_OF_THE_NUCLEUS": "Degradation of a cell nucleus by microautophagy. [GOC:autophagy, GOC:jp, PMID:18701704]", "GOBP_PIGMENT_ACCUMULATION": "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. [GOC:jl]", "GOBP_PIGMENTATION": "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. [GOC:jl]", "GOBP_PIGMENT_CATABOLIC_PROCESS": "", "GOBP_PIGMENT_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. [ISBN:0198506732]", "GOBP_PIGMENT_GRANULE_LOCALIZATION": "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. [GOC:ai]", "GOBP_PIGMENT_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. [GOC:dgh]", "GOBP_PIGMENT_GRANULE_MATURATION": "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state. [GOC:dgh, GOC:jid, GOC:mh]", "GOBP_PIGMENT_GRANULE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. [GOC:rc]", "GOBP_PIGMENT_METABOLIC_PROCESS": "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. [GOC:jl, ISBN:0198506732]", "GOBP_PINOCYTOSIS": "An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. [ISBN:0198506732]", "GOBP_PIRNA_MEDIATED_RETROTRANSPOSON_SILENCING_BY_HETEROCHROMATIN_FORMATION": "", "GOBP_PIRNA_PROCESSING": "A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]", "GOBP_PLACENTA_BLOOD_VESSEL_DEVELOPMENT": "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. [GOC:dph, PMID:16916377]", "GOBP_PITUITARY_GLAND_DEVELOPMENT": "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_PLANAR_CELL_POLARITY_PATHWAY_INVOLVED_IN_AXIS_ELONGATION": "", "GOBP_PLASMA_CELL_DIFFERENTIATION": "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. [GOC:jal]", "GOBP_PLANAR_CELL_POLARITY_PATHWAY_INVOLVED_IN_NEURAL_TUBE_CLOSURE": "", "GOBP_PLACENTA_DEVELOPMENT": "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]", "GOBP_PLASMA_MEMBRANE_FUSION": "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. [GOC:elh, GOC:mtg_muscle]", "GOBP_PLASMA_MEMBRANE_PHOSPHOLIPID_SCRAMBLING": "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). [GOC:cjm, PMID:20043909, PMID:20302864]", "GOBP_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE": "The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:mah, GOC:tb]", "GOBP_PLASMA_MEMBRANE_RAFT_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft. [GOC:jl]", "GOBP_PLASMA_MEMBRANE_RAFT_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts. [GOC:jl]", "GOBP_PLASMA_MEMBRANE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_PLASMA_MEMBRANE_TO_ENDOSOME_TRANSPORT": "Transport of a vesicle from the plasma membrane to the endosome. [GOC:jid]", "GOBP_PLASMA_MEMBRANE_REPAIR": "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. [GOC:add, PMID:12925704]", "GOBP_PLASMA_MEMBRANE_TUBULATION": "A membrane tubulation process occurring in a plasma membrane. [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]", "GOBP_PLASMINOGEN_ACTIVATION": "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide. [PMID:9548733]", "GOBP_PLATELET_ACTIVATING_FACTOR_METABOLIC_PROCESS": "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. [ISBN:0198547684]", "GOBP_PLATELET_ACTIVATION": "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. [PMID:27403440]", "GOBP_PLATELET_AGGREGATION": "The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk]", "GOBP_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_ALPHA_SIGNALING_PATHWAY": "The series of molecular signals initiated a ligand binding to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:yaf, PMID:10372961]", "GOBP_PLATELET_DEGRANULATION": "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. [GOC:add]", "GOBP_PLATELET_DENSE_GRANULE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. [GOC:dph, PMID:11487378]", "GOBP_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BETA_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961]", "GOBP_PLUS_END_DIRECTED_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE": "The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. [GOC:BHF, GOC:mah]", "GOBP_PLATELET_MORPHOGENESIS": "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. [CL:0000233, GOC:BHF, GOC:vk]", "GOBP_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]", "GOBP_PML_BODY_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia). [GOC:mah, PMID:10806078]", "GOBP_PODOCYTE_CELL_MIGRATION": "The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell. [GOC:pm, PMID:21402783]", "GOBP_POINTED_END_ACTIN_FILAMENT_CAPPING": "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. [ISBN:071673706X]", "GOBP_PODOSOME_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. [GOC:mah, GOC:sl]", "GOBP_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. [GOC:mah]", "GOBP_POLAR_BODY_EXTRUSION_AFTER_MEIOTIC_DIVISIONS": "The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes. [GOC:ems, ISBN:0198506732]", "GOBP_POLYAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]", "GOBP_POLYOL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. [GOC:curators]", "GOBP_POLYKETIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. [GOC:mah, ISBN:0198506732]", "GOBP_POLYAMINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]", "GOBP_POLYOL_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. [GOC:curators]", "GOBP_POLYAMINE_TRANSPORT": "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc, ISBN:0198506732]", "GOBP_POLYOL_TRANSMEMBRANE_TRANSPORT": "The directed movement of polyols, any polyhydric alcohol, across a membrane. [GOC:ai]", "GOBP_POLYPRENOL_METABOLIC_PROCESS": "", "GOBP_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:go_curators]", "GOBP_POLYOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. [PMID:30240188]", "GOBP_POLYSACCHARIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [PMID:33139480]", "GOBP_POLY_N_ACETYLLACTOSAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. [GOC:mah, PMID:9405606]", "GOBP_POLY_A_DEPENDENT_SNORNA_3_END_PROCESSING": "Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA. [GOC:dgf, GOC:krc, PMID:18951092]", "GOBP_POLY_A_PLUS_MRNA_EXPORT_FROM_NUCLEUS": "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. [GOC:ai]", "GOBP_PONS_DEVELOPMENT": "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_POLYSACCHARIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [ISBN:0198547684]", "GOBP_PORE_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. [GOC:jl, GOC:mah]", "GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]", "GOBP_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS": "", "GOBP_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_GENOME_REPLICATION": "", "GOBP_POSITIVE_CHEMOTAXIS": "The directed movement of a motile cell or organism towards a higher concentration of a chemical. [GOC:ai, GOC:bf, GOC:isa_complete]", "GOBP_POSITIVE_REGULATION_OF_3_UTR_MEDIATED_MRNA_STABILIZATION": "Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization. [GO_REF:0000058, GOC:TermGenie, PMID:19737525]", "GOBP_POSITIVE_REGULATION_BY_SYMBIONT_OF_ENTRY_INTO_HOST": "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. [GOC:pamgo_curators]", "GOBP_POSITIVE_REGULATION_OF_ACROSOME_REACTION": "Any process that activates or increases the frequency, rate or extent of the acrosome reaction. [GOC:obol]", "GOBP_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION": "", "GOBP_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION": "Any process that activates or increases the frequency, rate or extent of actin depolymerization. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION": "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION": "Any process that activates or increases the rate or extent of activated T cell proliferation. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_ACTION_POTENTIAL": "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION": "Any process that activates or increases the frequency, rate or extent of actin polymerization. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE": "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl]", "GOBP_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS": "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]", "GOBP_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE": "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_AGGREPHAGY": "Any process that activates or increases the frequency, rate or extent of aggrephagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]", "GOBP_POSITIVE_REGULATION_OF_ADIPOSE_TISSUE_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]", "GOBP_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]", "GOBP_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_AMINE_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT": "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_FORMATION": "Any process that activates or increases the frequency, rate or extent of amyloid-beta formation. [GOC:dph, GOC:TermGenie, PMID:17098871]", "GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_CLEARANCE": "Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance. [GOC:BHF, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_AMINE_TRANSPORT": "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_AMYLOID_FIBRIL_FORMATION": "Any process that activates or increases the frequency, rate or extent of amyloid fibril formation. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]", "GOBP_POSITIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]", "GOBP_POSITIVE_REGULATION_OF_ANOIKIS": "Any process that activates or increases the frequency, rate or extent of anoikis. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION": "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_ANIMAL_ORGAN_MORPHOGENESIS": "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. [GOC:kmv]", "GOBP_POSITIVE_REGULATION_OF_ANTIBACTERIAL_PEPTIDE_PRODUCTION": "", "GOBP_POSITIVE_REGULATION_OF_ANTIMICROBIAL_HUMORAL_RESPONSE": "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. [GO_REF:0000058, GOC:TermGenie, PMID:22801495]", "GOBP_POSITIVE_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS": "", "GOBP_POSITIVE_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE": "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_POSITIVE_REGULATION_OF_ARTERY_MORPHOGENESIS": "Any process that activates or increases the frequency, rate or extent of artery morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]", "GOBP_POSITIVE_REGULATION_OF_ASPARTIC_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. [GOC:vp, PMID:15139015]", "GOBP_POSITIVE_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION": "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation. [PMID:21454476]", "GOBP_POSITIVE_REGULATION_OF_ATP_BIOSYNTHETIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_ATP_DEPENDENT_ACTIVITY": "Any process that activates or increases the rate of an ATP-dependent activity. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE": "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_AUTOPHAGOSOME_MATURATION": "Any process that activates or increases the frequency, rate or extent of autophagosome maturation. [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]", "GOBP_POSITIVE_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly. [GOC:autophagy, GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION": "Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy. [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002]", "GOBP_POSITIVE_REGULATION_OF_AXON_EXTENSION": "Any process that activates or increases the frequency, rate or extent of axon extension. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_AXONOGENESIS": "Any process that activates or increases the frequency, rate or extent of axonogenesis. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE": "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance. [GOC:devbiol]", "GOBP_POSITIVE_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of tight junction assembly. [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]", "GOBP_POSITIVE_REGULATION_OF_BEHAVIOR": "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. [GOC:jid, GOC:pr]", "GOBP_POSITIVE_REGULATION_OF_AUTOPHAGY": "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_BASEMENT_MEMBRANE_ASSEMBLY_INVOLVED_IN_EMBRYONIC_BODY_MORPHOGENESIS": "", "GOBP_POSITIVE_REGULATION_OF_BINDING": "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_BLOOD_BRAIN_BARRIER_PERMEABILITY": "Any process that increases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653]", "GOBP_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION": "Any process that activates or increases the frequency, rate or extent of blood circulation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]", "GOBP_POSITIVE_REGULATION_OF_BLOOD_PRESSURE": "Any process in which the force of blood traveling through the circulatory system is increased. [GOC:go_curators, GOC:mtg_cardio]", "GOBP_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION": "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_BLOOD_VESSEL_REMODELING": "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_PROLIFERATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS": "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:23388056]", "GOBP_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_BONE_MINERALIZATION": "Any process that activates or increases the frequency, rate or extent of bone mineralization. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION": "Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_BONE_RESORPTION": "Any process that activates or increases the frequency, rate or extent of bone resorption. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of B cell activation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of B cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CALCINEURIN_MEDIATED_SIGNALING": "Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling. [PMID:25081204]", "GOBP_POSITIVE_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY": "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION": "Any process that activates or increases the rate or extent of B cell proliferation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT": "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]", "GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS": "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:22910094]", "GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL": "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING": "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING": "", "GOBP_POSITIVE_REGULATION_OF_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION": "Any process that starts or increases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:rph, PMID:20951801]", "GOBP_POSITIVE_REGULATION_OF_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION": "Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_ADAPTATION": "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY": "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]", "GOBP_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION": "Any process that increases the frequency, rate or extent of cardiac muscle contraction. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CARDIOCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]", "GOBP_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT": "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of cation channel activity. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION": "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation. [GOC:add, GOC:pr, ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY": "Any process that activates or increases the activity of an enzyme. [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]", "GOBP_POSITIVE_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation. [GOC:add, ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_PH_REDUCTION": "", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION": "Any process that activates or increases the frequency, rate, or extent of cellular extravasation. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS": "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. [GOC:TermGenie, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS": "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_RESPIRATION": "Any process that activates or increases the frequency, rate or extent of cellular respiration. [GOC:TermGenie, GOC:yaf, PMID:23150719]", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS": "Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_SENESCENCE": "Any process that activates or increases the frequency, rate or extent of cellular senescence. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION": "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN": "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION_MOLECULE_PRODUCTION": "", "GOBP_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_INTEGRIN": "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of activation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN": "Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION": "Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_CHECKPOINT": "Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]", "GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION": "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION": "Any process that activates or increases the rate or extent of cell adhesion to another cell. [GOC:isa_complete]", "GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION": "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. [GO_REF:0000058, GOC:jl, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE": "Any process that activates or increases the rate or extent of progression through the cell cycle. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION": "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "GOBP_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT": "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS": "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT": "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CELL_DIVISION": "Any process that activates or increases the frequency, rate or extent of cell division. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_CELL_GROWTH_INVOLVED_IN_CARDIAC_MUSCLE_CELL_DEVELOPMENT": "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_CELL_GROWTH": "Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of cell junction assembly. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CELL_KILLING": "Any process that activates or increases the frequency, rate or extent of cell killing. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CELL_MATURATION": "Any process that activates or increases the frequency, rate or extent of cell maturation. [GO_REF:0000058, GOC:TermGenie, PMID:17459944]", "GOBP_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION": "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. [GOC:hjd]", "GOBP_POSITIVE_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS": "Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS": "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS": "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CELL_PROLIFERATION_IN_BONE_MARROW": "A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow. [GOC:mah, GOC:yaf, PMID:17063141]", "GOBP_POSITIVE_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development. [GOC:TermGenie, PMID:18182616]", "GOBP_POSITIVE_REGULATION_OF_CELL_SIZE": "Any process that increases cell size. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION": "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION": "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. [GOC:dph, GOC:pf, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_JUNCTION_ORGANIZATION": "Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization. [GOC:aruk]", "GOBP_POSITIVE_REGULATION_OF_CENTRIOLE_ELONGATION": "Any process that activates or increases the frequency, rate or extent of centriole elongation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]", "GOBP_POSITIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION": "Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CENTRIOLE_REPLICATION": "Any process that activates or increases the frequency, rate or extent of centriole replication. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_CEREBELLAR_GRANULE_CELL_PRECURSOR_PROLIFERATION": "The process that activates or increases the rate or extent of granule cell precursor proliferation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]", "GOBP_POSITIVE_REGULATION_OF_CGMP_MEDIATED_SIGNALING": "", "GOBP_POSITIVE_REGULATION_OF_CHEMOKINE_C_X_C_MOTIF_LIGAND_1_PRODUCTION": "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CHEMOKINE_C_C_MOTIF_LIGAND_5_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CHEMOKINE_C_X_C_MOTIF_LIGAND_2_PRODUCTION": "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS": "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX": "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CHROMATIN_BINDING": "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:bf, PMID:20404130]", "GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_STORAGE": "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CHONDROCYTE_PROLIFERATION": "Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]", "GOBP_POSITIVE_REGULATION_OF_CHEMOTAXIS": "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_CHROMATIN_ORGANIZATION": "", "GOBP_POSITIVE_REGULATION_OF_CHROMOSOME_CONDENSATION": "Any process that activates or increases the frequency, rate or extent of chromosome condensation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547]", "GOBP_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION": "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION": "Any process that activates or increases the frequency, rate or extent of chromosome organization. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_CILIUM_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of the formation of a cilium. [GOC:cilia, GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM": "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CILIUM_MOVEMENT": "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_CHROMOSOME_SEPARATION": "Any process that activates or increases the frequency, rate or extent of chromosome separation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393]", "GOBP_POSITIVE_REGULATION_OF_COA_TRANSFERASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_COAGULATION": "Any process that activates or increases the frequency, rate or extent of coagulation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_COLD_INDUCED_THERMOGENESIS": "Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]", "GOBP_POSITIVE_REGULATION_OF_COLLATERAL_SPROUTING": "Any process that activates or increases the frequency, rate or extent of collateral sprouting. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]", "GOBP_POSITIVE_REGULATION_OF_COMPLEMENT_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of complement activation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_CONNECTIVE_TISSUE_REPLACEMENT": "Any process that activates or increases the frequency, rate or extent of connective tissue replacement. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]", "GOBP_POSITIVE_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION": "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion. [GOC:sl]", "GOBP_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY": "Any process that activates or increases the activity of a cyclase. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. [GOC:dph, GOC:ecd, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY": "", "GOBP_POSITIVE_REGULATION_OF_CYTOKINESIS": "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE": "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY": "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. [GOC:dph, GOC:krc, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE": "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSLATIONAL_INITIATION": "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation. [GO_REF:0000058, GOC:TermGenie, PMID:12242291]", "GOBP_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSLATION": "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION": "Any process that activates or increases the frequency, rate or extent of production of a cytokine. [GOC:add, ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION": "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM": "Any process that activates or increases the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749]", "GOBP_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION": "Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of dendrite development. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST": "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication. [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_DENDRITIC_CELL_CYTOKINE_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION": "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE": "Any process that activates or increases the frequency, rate or extent of a defense response. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT": "Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS": "Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MAINTENANCE": "Any process that activates or increases the frequency, rate or extent of dendritic spine maintenance. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]", "GOBP_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION": "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_DEOXYRIBONUCLEASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION": "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. [GOC:dph, GOC:jid, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_DNA_BINDING": "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS": "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH": "Any process that activates, maintains or increases the rate of developmental growth. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_DNA_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of DNA catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:2001740]", "GOBP_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR": "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_DNA_DAMAGE_CHECKPOINT": "Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_DNA_LIGATION": "", "GOBP_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR_RESULTING_IN_TRANSCRIPTION_OF_P21_CLASS_MEDIATOR": "", "GOBP_POSITIVE_REGULATION_OF_DNA_METHYLATION_DEPENDENT_HETEROCHROMATIN_FORMATION": "", "GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS": "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_DNA_TEMPLATED_DNA_REPLICATION": "Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_DNA_REPAIR": "Any process that activates or increases the frequency, rate or extent of DNA repair. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_DNA_RECOMBINATION": "Any process that activates or increases the frequency, rate or extent of DNA recombination. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_DNA_REPLICATION": "Any process that activates or increases the frequency, rate or extent of DNA replication. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_DOPAMINE_SECRETION": "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine. [GOC:sl]", "GOBP_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION": "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]", "GOBP_POSITIVE_REGULATION_OF_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION": "Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. [GOC:mah, GOC:txnOH]", "GOBP_POSITIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR": "Any process that activates or increases the frequency, rate or extent of double-strand break repair. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION": "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination. [GO_REF:0000058, GOC:TermGenie, PMID:12023299]", "GOBP_POSITIVE_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_NONHOMOLOGOUS_END_JOINING": "Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of embryonic development. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_ENAMEL_MINERALIZATION": "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ENDOCYTIC_RECYCLING": "Any process that activates or increases the frequency, rate or extent of endocytic recycling. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE": "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]", "GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS": "Any process that activates or increases the frequency, rate or extent of endocytosis. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS": "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]", "GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of endothelial cell development. [GOC:pr, GOC:TermGenie, PMID:19470579]", "GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MATRIX_ADHESION_VIA_FIBRONECTIN": "", "GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION": "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION": "Any process that activates or increases the rate or extent of endothelial cell proliferation. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19137015]", "GOBP_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of epidermis development. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development. [GOC:mtg_kidney_jan10, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_LUNG_MORPHOGENESIS": "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION": "Any process that activates or increases the frequency, rate or extent of epithelial cell migration. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_WOUND_HEALING": "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION": "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION": "Any process that activates or increases the rate or extent of epithelial cell proliferation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_ERAD_PATHWAY": "Any process that activates or increases the frequency, rate or extent of ERAD pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_TUBE_FORMATION": "Any process that activates or increases the frequency, rate or extent of epithelial tube formation. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]", "GOBP_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. [GOC:BHF, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_TELOMERE": "", "GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION": "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:16857185]", "GOBP_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS": "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. [GOC:mtg_apoptosis, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION": "Any process that activates or increases the frequency, rate or extent of establishment of protein localization. [GO_REF:0000058, GOC:TermGenie, PMID:22761445]", "GOBP_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL": "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:bf, GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_EXIT_FROM_MITOSIS": "", "GOBP_POSITIVE_REGULATION_OF_EXOCYTOSIS": "Any process that activates or increases the frequency, rate or extent of exocytosis. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_EXOSOMAL_SECRETION": "Any process that activates or increases the frequency, rate or extent of exosomal secretion. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]", "GOBP_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. [GOC:BHF, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY": "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION": "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]", "GOBP_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND": "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]", "GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BETA_OXIDATION": "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS": "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. [GOC:TermGenie, PMID:17245429]", "GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION": "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_FATTY_ACID_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of fatty acid transport. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY": "Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_FEEDING_BEHAVIOR": "Any process that activates or increases the frequency, rate or extent of feeding behavior. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_FEAR_RESPONSE": "Any process that activates or increases the frequency, rate or extent of fear response. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]", "GOBP_POSITIVE_REGULATION_OF_FERTILIZATION": "Any process that activates or increases the frequency, rate or extent of fertilization. [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576]", "GOBP_POSITIVE_REGULATION_OF_FEVER_GENERATION": "Any process that activates or increases the frequency, rate, or extent of fever generation. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION": "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]", "GOBP_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_FOCAL_ADHESION_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_G0_TO_G1_TRANSITION": "A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_GAMMA_DELTA_T_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_GAMMA_DELTA_T_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE": "Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]", "GOBP_POSITIVE_REGULATION_OF_GAP_JUNCTION_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of gap junction assembly. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]", "GOBP_POSITIVE_REGULATION_OF_GASTRO_INTESTINAL_SYSTEM_SMOOTH_MUSCLE_CONTRACTION": "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. [GO_REF:0000058, GOC:TermGenie, PMID:10821044]", "GOBP_POSITIVE_REGULATION_OF_GASTRULATION": "Any process that activates or increases the frequency, rate or extent of gastrulation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION_VIA_CHROMOSOMAL_CPG_ISLAND_DEMETHYLATION": "An epigenetic gene regulation mechanism that positively regulates gene expression by demethylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. [PMID:36150101, Wikipedia:Cpg_island]", "GOBP_POSITIVE_REGULATION_OF_GLIAL_CELL_MIGRATION": "Any process that activates or increases the frequency, rate or extent of glial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]", "GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC": "An epigenetic process that increases gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA demethylation. [PMID:36618446]", "GOBP_POSITIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION": "Any process that activates or increases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of glia cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_GLOMERULUS_DEVELOPMENT": "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. [GOC:dph, GOC:tb, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_GLOMERULAR_MESANGIAL_CELL_PROLIFERATION": "Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation. [GOC:mtg_kidney_jan10]", "GOBP_POSITIVE_REGULATION_OF_GLIOGENESIS": "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. [GOC:ef]", "GOBP_POSITIVE_REGULATION_OF_GLUCONEOGENESIS": "Any process that activates or increases the frequency, rate or extent of gluconeogenesis. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION": "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]", "GOBP_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT": "", "GOBP_POSITIVE_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT": "", "GOBP_POSITIVE_REGULATION_OF_GLYCOGEN_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_GLUTAMATE_SECRETION": "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]", "GOBP_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS": "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. [GOC:BHF, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]", "GOBP_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_GONADOTROPIN_SECRETION": "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_GONAD_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of gonad development. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]", "GOBP_POSITIVE_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS": "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION": "", "GOBP_POSITIVE_REGULATION_OF_GROWTH_HORMONE_SECRETION": "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_GROWTH": "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of hair follicle development. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_HAIR_FOLLICLE_MATURATION": "Any process that activates or increases the frequency, rate or extent of hair follicle maturation. [GOC:devbiol]", "GOBP_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_GTPASE_ACTIVITY": "Any process that activates or increases the activity of a GTPase. [GOC:jl, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_HEART_RATE": "Any process that activates or increases the frequency or rate of heart contraction. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_HEART_GROWTH": "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_HEAT_GENERATION": "Any process that activates or increases the rate or extent of heat generation. [GOC:dph, GOC:mah, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_HELICASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. [GOC:BHF, GOC:rl, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_HEMOGLOBIN_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_HEMATOPOIETIC_STEM_CELL_PROLIFERATION": "", "GOBP_POSITIVE_REGULATION_OF_HEPATIC_STELLATE_CELL_ACTIVATION": "", "GOBP_POSITIVE_REGULATION_OF_HEPATOCYTE_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION": "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_HIPPO_SIGNALING": "Any process that activates or increases the frequency, rate or extent of hippo signaling. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE": "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_HEMOPOIESIS": "Any process that activates or increases the frequency, rate or extent of hemopoiesis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]", "GOBP_POSITIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION": "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE": "Any process that activates or increases the frequency, rate, or extent of a humoral immune response. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN": "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION": "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_IMMATURE_T_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation. [GOC:add, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_HYPERSENSITIVITY": "", "GOBP_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS": "Any process that activates or increases the frequency, rate, or extent of an immune effector process. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS": "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of an inflammasome-mediated signaling pathway. [PMID:33467177]", "GOBP_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE": "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE": "Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS": "Any process that activates or increases the frequency, rate, or extent of an immune system process. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS": "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION": "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTEGRIN_ACTIVATION": "Any process that activates or increases the frequency, rate, or extent of integrin activation. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_INTEGRIN_MEDIATED_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]", "GOBP_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_1_ALPHA_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_18_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION": "", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_23_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_5_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT": "", "GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. [GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]", "GOBP_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE": "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]", "GOBP_POSITIVE_REGULATION_OF_ISOTYPE_SWITCHING": "Any process that activates or increases the frequency, rate or extent of isotype switching. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE": "Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]", "GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION": "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_ISOTYPE_SWITCHING_TO_IGG_ISOTYPES": "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes. [GOC:jid]", "GOBP_POSITIVE_REGULATION_OF_I_KAPPAB_PHOSPHORYLATION": "", "GOBP_POSITIVE_REGULATION_OF_JNK_CASCADE": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of JUN kinase activity. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_KERATINOCYTE_APOPTOTIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION": "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT": "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:tb, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY": "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_KINASE_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_LAMELLIPODIUM_MORPHOGENESIS": "Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION": "Any process that activates or increases the frequency, rate or extent of lamellipodium organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL": "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION": "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. [GOC:add, ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS": "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY": "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_TETHERING_OR_ROLLING": "Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]", "GOBP_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY": "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION": "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION": "Any process that activates or increases the frequency, rate, or extent of leukocyte migration. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. [GOC:add, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION": "Any process that activates or increases the frequency, rate or extent of lipid localization. [GO_REF:0000058, GOC:TermGenie, PMID:17564681]", "GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_LIPID_STORAGE": "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE": "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY": "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. [GOC:jid, PMID:11891290]", "GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION": "Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_DEPRESSION": "Any process that activates or increases the frequency, rate or extent of long term synaptic depression. [GOC:BHF, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_LYASE_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_POSITIVE_REGULATION_OF_LOCOMOTION": "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_ANERGY": "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS": "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis. [PMID:19255442]", "GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_LYSOSOMAL_PROTEIN_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION": "Any process that activates or increases the frequency, rate or extent of lymphocyte migration. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS": "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MACROAUTOPHAGY": "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. [GOC:go_curators, PMID:9412464]", "GOBP_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION": "Any process that stimulates, induces or increases the rate of macrophage activation. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION": "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of macrophage differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION": "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MACROPHAGE_MIGRATION": "Any process that activates or increases the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]", "GOBP_POSITIVE_REGULATION_OF_MAINTENANCE_OF_SISTER_CHROMATID_COHESION": "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained. [GOC:mah, GOC:vw]", "GOBP_POSITIVE_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION": "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MAPKKK_CASCADE_BY_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate, or extent of mast cell activation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MAST_CELL_CHEMOTAXIS": "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION": "Any process that activates or increases the frequency, rate or extent of mast cell degranulation. [ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE": "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION": "Any process that activates or increases the frequency, rate or extent of meiosis. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MELANOCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION": "Any process that activates or increases the frequency, rate or extent of membrane depolarization. [GO_REF:0000058, GOC:TermGenie, PMID:20826763]", "GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE": "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MEMBRANE_POTENTIAL": "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS": "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_MEMORY_T_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation. [ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_MEMBRANE_PERMEABILITY": "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane. [PMID:27482894]", "GOBP_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION": "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_MESENCHYMAL_STEM_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell proliferation. [GOC:pm, GOC:TermGenie, PMID:18672106]", "GOBP_POSITIVE_REGULATION_OF_METALLOENDOPEPTIDASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_METALLOPEPTIDASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE": "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. [GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MICROGLIAL_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of microglial cell activation. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]", "GOBP_POSITIVE_REGULATION_OF_MHC_CLASS_I_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MICROTUBULE_NUCLEATION": "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION": "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MIRNA_PROCESSING": "Any process that activates or increases the frequency, rate or extent of microRNA processing. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]", "GOBP_POSITIVE_REGULATION_OF_MIRNA_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_MIRNA_TRANSCRIPTION": "", "GOBP_POSITIVE_REGULATION_OF_MITOCHONDRIAL_CALCIUM_ION_CONCENTRATION": "Any process that increases the concentration of calcium ions in mitochondria. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION": "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION": "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FUSION": "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL": "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY": "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. [GOC:bf, PMID:12546810]", "GOBP_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_MITOCHONDRIAL_TRANSLATION": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION": "Any process that activates or increases the frequency, rate or extent of mitosis. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MITOPHAGY": "", "GOBP_POSITIVE_REGULATION_OF_MITOTIC_CYTOKINESIS": "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis. [GO_REF:0000058, GOC:TermGenie, PMID:24920823]", "GOBP_POSITIVE_REGULATION_OF_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION": "", "GOBP_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION": "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. [GOC:TermGenie, PMID:1846086]", "GOBP_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEGREGATION": "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. [PMID:12773390]", "GOBP_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE": "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS": "Any process that increases the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTACTIC_PROTEIN_1_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MONOATOMIC_ION_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION": "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GO:jl]", "GOBP_POSITIVE_REGULATION_OF_MONOCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of monocyte differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION": "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MONOCYTE_EXTRAVASATION": "Any process that activates or increases the frequency, rate or extent of monocyte extravasation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_MRNA_CATABOLIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_MORPHOGENESIS_OF_AN_EPITHELIUM": "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]", "GOBP_POSITIVE_REGULATION_OF_MUCUS_SECRETION": "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_MRNA_PROCESSING": "Any process that activates or increases the frequency, rate or extent of mRNA processing. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_POSITIVE_REGULATION_OF_MUSCLE_ADAPTATION": "Any process that activates or increases the frequency, rate or extent of muscle adaptation. [GOC:mtg_muscle]", "GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH": "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION": "Any process that activates or increases the frequency, rate or extent of muscle contraction. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. [CL:0000187, GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY": "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. [GOC:mtg_muscle]", "GOBP_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT": "", "GOBP_POSITIVE_REGULATION_OF_MYELINATION": "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS": "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]", "GOBP_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE": "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. [GOC:BHF, GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY": "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_MYOBLAST_FUSION": "Any process that activates or increases the frequency, rate or extent of myoblast fusion. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]", "GOBP_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION": "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_MYOBLAST_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of myoblast proliferation. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]", "GOBP_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_CHEMOTAXIS": "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of natural killer cell activation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY": "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL": "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY": "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_PROLIFERATION": "", "GOBP_POSITIVE_REGULATION_OF_NECROPTOTIC_PROCESS": "Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION": "Any process that activates or increases the rate of neuroblast proliferation. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_NEUROEPITHELIAL_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506]", "GOBP_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_PROCESS": "Any process that activates or increases the frequency, rate or extent of a neurophysiological process. [GOC:dph, GOC:mah, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. [GOC:dph, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_NEUROINFLAMMATORY_RESPONSE": "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc]", "GOBP_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT": "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_NEUROGENESIS": "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_NEURON_MIGRATION": "Any process that activates or increases the frequency, rate or extent of neuron migration. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]", "GOBP_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of neuron differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_NEURON_PROJECTION_ARBORIZATION": "Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. [GOC:aruk, GOC:bc, PMID:17114044]", "GOBP_POSITIVE_REGULATION_OF_NEURON_PROJECTION_REGENERATION": "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION": "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. [GOC:hjd]", "GOBP_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_UPTAKE": "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT": "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION": "Any process that activates or increases the frequency, rate or extent of neutrophil migration. [GO_REF:0000058, GOC:TermGenie, PMID:1826836]", "GOBP_POSITIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]", "GOBP_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_NK_T_CELL_ACTIVATION": "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation. [ISBN:0781735149, PMID:12154375, PMID:9133426]", "GOBP_POSITIVE_REGULATION_OF_NON_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION": "Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. [GOC:obol, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_NON_MOTILE_CILIUM_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly. [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208]", "GOBP_POSITIVE_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION": "Any process that activates or increases the frequency, rate or extent of the DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. [GOC:mtg_cell_cycle]", "GOBP_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY": "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION": "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_NUCLEOTIDE_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ODONTOGENESIS": "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. [GOC:vp, PMID:15139015]", "GOBP_POSITIVE_REGULATION_OF_OPSONIZATION": "", "GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of organelle assembly. [GOC:pr, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION": "Any process that activates or increases the rate or extent of osteoblast proliferation. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION": "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]", "GOBP_POSITIVE_REGULATION_OF_ORGAN_GROWTH": "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. [GOC:bf, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_OSSIFICATION": "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_P38MAPK_CASCADE": "Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY": "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY": "Any process that decreases the rate, frequency or extent of a pattern recognition receptor signaling pathway. [PMID:30610168]", "GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION": "Any process that activates or increases the frequency, rate, or extent of peptide secretion. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_PEPTIDYL_LYSINE_ACETYLATION": "", "GOBP_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION": "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION": "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION": "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_PHAGOCYTOSIS": "Any process that activates or increases the frequency, rate or extent of phagocytosis. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10657240]", "GOBP_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_PROTEIN_KINASE_B_SIGNAL_TRANSDUCTION": "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSLOCATION": "", "GOBP_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_PINOCYTOSIS": "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_PHOSPHORYLATION": "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_PLASMINOGEN_ACTIVATION": "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PLATELET_ACTIVATION": "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PLASMA_MEMBRANE_BOUNDED_CELL_PROJECTION_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. [GOC:krc]", "GOBP_POSITIVE_REGULATION_OF_PLATELET_AGGREGATION": "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:fj, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PODOSOME_ASSEMBLY": "Any process that activates or increases the rate or extent of podosome assembly. [GOC:mah, GOC:sl]", "GOBP_POSITIVE_REGULATION_OF_POST_TRANSCRIPTIONAL_GENE_SILENCING": "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_POST_TRANSLATIONAL_PROTEIN_MODIFICATION": "Any process that activates or increases the frequency, rate or extent of post-translational protein modification. [GOC:TermGenie, GOC:yaf, PMID:21209915]", "GOBP_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. [GOC:BHF, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE": "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_PROGRAMMED_NECROTIC_CELL_DEATH": "Any process that increases the frequency, rate or extent of programmed necrotic cell death. [GOC:aruk, GOC:rph, PMID:27258785]", "GOBP_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]", "GOBP_POSITIVE_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION": "Any process that activates or increases the frequency, rate or extent of protein acetylation. [GOC:TermGenie, PMID:22117195]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION": "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_BINDING": "Any process that activates or increases the frequency, rate or extent of protein binding. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH": "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS_IN_THE_VACUOLE": "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_DEPHOSPHORYLATION": "", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY": "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION": "", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION": "Any process that activates or increases the frequency, rate or extent of protein depolymerization. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of protein complex assembly. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM": "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_DEUBIQUITINATION": "Any process that activates or increases the frequency, rate or extent of protein deubiquitination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS": "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS": "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_GLYCOSYLATION": "", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_K63_LINKED_UBIQUITINATION": "Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination. [GOC:TermGenie, PMID:21931591]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING": "", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING": "", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_KINASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE": "Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_CORTEX": "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CENTROSOME": "Any process that activates or increases the frequency, rate or extent of protein localization to centrosome. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CILIUM": "Any process that activates or increases the frequency, rate or extent of protein localization to cilium. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY": "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_EARLY_ENDOSOME": "Any process that activates or increases the frequency, rate or extent of protein localization to early endosome. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION": "Any process that activates or increases the frequency, rate or extent of a protein localization. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEOLUS": "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE": "Any process that activates or increases the frequency, rate or extent of protein localization to membrane. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS": "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_SYNAPSE": "Any process that activates or increases the frequency, rate or extent of protein localization to synapse. [GOC:kmv, GOC:TermGenie, PMID:22588719]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE": "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_MONOUBIQUITINATION": "Any process that activates or increases the frequency, rate or extent of protein monoubiquitination. [GOC:TermGenie, PMID:21931591]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_MATURATION": "Any process that activates or increases the frequency, rate or extent of protein maturation. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_NEDDYLATION": "Any process that activates or increases the frequency, rate or extent of protein neddylation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_POLYUBIQUITINATION": "Any process that activates or increases the frequency, rate or extent of protein polyubiquitination. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION": "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS": "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. [GOC:mah, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY": "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION": "Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION": "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE": "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY": "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_PROTEIN_UBIQUITINATION": "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_PROTEOLYSIS_INVOLVED_IN_PROTEIN_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]", "GOBP_POSITIVE_REGULATION_OF_PYROPTOSIS": "", "GOBP_POSITIVE_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. [GOC:pg]", "GOBP_POSITIVE_REGULATION_OF_PROTEOLYSIS": "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]", "GOBP_POSITIVE_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_RECEPTOR_BINDING": "", "GOBP_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of receptor catabolic process. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION": "Any process that activates or increases the frequency, rate or extent of receptor internalization. [GOC:hjd]", "GOBP_POSITIVE_REGULATION_OF_RECEPTOR_CLUSTERING": "Any process that activates or increases the frequency, rate or extent of receptor clustering. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]", "GOBP_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS": "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING": "Any process that activates or increases the frequency, rate or extent of receptor recycling. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. [ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY": "Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]", "GOBP_POSITIVE_REGULATION_OF_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT": "Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT. [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]", "GOBP_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA": "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL": "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_RESPIRATORY_BURST": "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS": "Any process that activates or increases the frequency, rate or extent of reproductive process. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS": "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]", "GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS": "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL": "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_TYPE_II_INTERFERON": "Any process that increases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_RIG_I_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity. [GOC:dgh]", "GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS": "Any process that activates, maintains or increases the rate of a response to an external stimulus. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING": "Any process that activates or increases the frequency, rate or extent of response to wounding. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535]", "GOBP_POSITIVE_REGULATION_OF_RNA_EXPORT_FROM_NUCLEUS": "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm. [GOC:bf]", "GOBP_POSITIVE_REGULATION_OF_RNA_BINDING": "", "GOBP_POSITIVE_REGULATION_OF_RRNA_PROCESSING": "Any process that activates or increases the frequency, rate or extent of rRNA processing. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_RNA_SPLICING": "Any process that activates or increases the frequency, rate or extent of RNA splicing. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_RUFFLE_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of ruffle assembly. [GOC:TermGenie, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. [GOC:di, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_SARCOMERE_ORGANIZATION": "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION": "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE": "", "GOBP_POSITIVE_REGULATION_OF_SIGNALING_RECEPTOR_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_SECRETION": "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_SISTER_CHROMATID_COHESION": "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR": "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_FIBER_DEVELOPMENT": "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]", "GOBP_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_REGENERATION": "Any process that activates or increase the rate of skeletal muscle regeneration. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT": "", "GOBP_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_GROWTH": "Any process that activates, maintains or increases the rate of skeletal muscle growth. [GOC:lm, PMID:15726494, PMID:15907921]", "GOBP_POSITIVE_REGULATION_OF_SIGNALING": "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. [GOC:mtg_signal]", "GOBP_POSITIVE_REGULATION_OF_SMAD_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that increases the rate, frequency or extent of SMAD protein signal transduction. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION": "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]", "GOBP_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of smoothened signaling. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. [CL:0000192, GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION": "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. [GOC:vw]", "GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION": "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]", "GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION": "Any process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]", "GOBP_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]", "GOBP_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_SPINDLE_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of spindle assembly. [GO_REF:0000058, GOC:TermGenie, PMID:27689799]", "GOBP_POSITIVE_REGULATION_OF_SPINDLE_CHECKPOINT": "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT": "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_SODIUM_PROTON_ANTIPORTER_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS": "Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958]", "GOBP_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of stem cell differentiation. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_STEROID_HORMONE_SECRETION": "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. [GOC:sl]", "GOBP_POSITIVE_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE": "Any process that activates or increases the frequency, rate or extent of stem cell population maintenance. [GOC:hjd, GOC:TermGenie, PMID:22969033]", "GOBP_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of stem cell proliferation. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE": "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_STRESS_GRANULE_ASSEMBLY": "", "GOBP_POSITIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY": "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION": "Any process that activates or increases the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. [CL:0000737, GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING": "Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. [GOC:TermGenie, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_SULFUR_METABOLIC_PROCESS": "", "GOBP_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION": "Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_PLASTICITY": "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY": "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]", "GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_CHOLINERGIC": "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC": "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC": "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION": "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_ENDOCYTOSIS": "", "GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING": "Any process that activates or increases the frequency, rate or extent of synaptic vesicle recycling. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]", "GOBP_POSITIVE_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION": "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE": "The process that increases the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]", "GOBP_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY": "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]", "GOBP_POSITIVE_REGULATION_OF_TELOMERE_CAPPING": "Any process that activates or increases the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "GOBP_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING": "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "GOBP_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE": "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION": "Any process that increases the force of heart muscle contraction. [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280]", "GOBP_POSITIVE_REGULATION_OF_THYROID_HORMONE_GENERATION": "", "GOBP_POSITIVE_REGULATION_OF_TISSUE_REMODELING": "Any process that activates or increases the frequency, rate, or extent of tissue remodeling. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_TOLERANCE_INDUCTION": "Any process that activates or increases the frequency, rate, or extent of tolerance induction. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_3_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_7_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_POSITIVE_REGULATION_OF_TOOTH_MINERALIZATION": "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_TOR_SIGNALING": "Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_TORC1_SIGNALING": "Any process that activates or increases the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]", "GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_GLUCOSE": "", "GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_I": "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. [GOC:go_curators, GOC:txnOH]", "GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_III": "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III. [GOC:go_curators, GOC:txnOH]", "GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_OF_NOTCH_RECEPTOR_TARGET": "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain. [PMID:12651094]", "GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_BY_RNA_POLYMERASE_II": "", "GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_OF_NUCLEOLAR_LARGE_RRNA_BY_RNA_POLYMERASE_I": "Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I. [GOC:sart, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING": "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA1_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II": "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]", "GOBP_POSITIVE_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL]", "GOBP_POSITIVE_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS": "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION": "Any process that activates or increases the frequency, rate or extent of translational initiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_TRANSLATION": "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY": "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. [GOC:dph, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE": "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY": "Any process that activates or increases the activity of a transporter. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS": "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. [GOC:rn, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS": "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. [GOC:BHF, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS": "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_TROPHOBLAST_CELL_MIGRATION": "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration. [GOC:BHF, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807]", "GOBP_POSITIVE_REGULATION_OF_TRANSPORT": "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE": "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY": "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]", "GOBP_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION": "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]", "GOBP_POSITIVE_REGULATION_OF_TYPE_II_INTERFERON_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]", "GOBP_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN": "", "GOBP_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION": "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS": "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. [GOC:add, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL": "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY": "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY": "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_MIGRATION": "Any process that activates or increases the frequency, rate or extent of T cell migration. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_T_HELPER_17_CELL_LINEAGE_COMMITMENT": "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION": "Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION": "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_T_HELPER_17_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_T_HELPER_17_TYPE_IMMUNE_RESPONSE": "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_T_HELPER_1_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE": "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]", "GOBP_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_T_HELPER_2_CELL_CYTOKINE_PRODUCTION": "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity. [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882]", "GOBP_POSITIVE_REGULATION_OF_UBIQUITIN_PROTEIN_TRANSFERASE_ACTIVITY": "Any process that activates, maintains or increases the rate of ubiquitin transferase activity. [GOC:ai, GOC:tb]", "GOBP_POSITIVE_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process. [GO:0006636]", "GOBP_POSITIVE_REGULATION_OF_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_URINE_VOLUME": "Any process that increases the amount of urine excreted from the body over a unit of time. [GOC:mtg_25march11, GOC:yaf]", "GOBP_POSITIVE_REGULATION_OF_UTERINE_SMOOTH_MUSCLE_CONTRACTION": "Any process that increases the frequency, rate or extent of uterine smooth muscle contraction. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION": "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. [GOC:jl, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_MIGRATION": "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_CELL_PROLIFERATION": "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION": "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. [GOC:BHF, GOC:rl]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway. [GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. [GOC:dgh]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_WOUND_HEALING": "Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:rph]", "GOBP_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY": "Any process that increases the extent to which blood vessels can be pervaded by fluid. [GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_VESICLE_FUSION": "Any process that activates or increases the frequency, rate or extent of vesicle fusion. [GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_VASCULOGENESIS": "Any process that activates or increases the frequency, rate or extent of vasculogenesis. [GOC:obol]", "GOBP_POSITIVE_REGULATION_OF_VASOCONSTRICTION": "Any process that activates or increases the frequency, rate or extent of vasoconstriction. [GOC:go_curators]", "GOBP_POSITIVE_REGULATION_OF_VESICLE_TRANSPORT_ALONG_MICROTUBULE": "", "GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT": "Any process that activates or increases the frequency, rate or extent of vasculature development. [GO_REF:0000058, GOC:TermGenie, PMID:21472453]", "GOBP_POSITIVE_REGULATION_OF_VIRAL_LIFE_CYCLE": "Any process that activates or increases the frequency, rate or extent of viral life cycle. [GO_REF:0000058, GOC:TermGenie, PMID:18005716]", "GOBP_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION": "Any process that activates or increases the frequency, rate or extent of viral genome replication. [GOC:ai]", "GOBP_POSITIVE_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY": "Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie]", "GOBP_POSITIVE_REGULATION_OF_VITAMIN_D_RECEPTOR_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity. [GOC:BHF, GOC:mah]", "GOBP_POSITIVE_REGULATION_OF_VIRAL_PROCESS": "Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. [GOC:bf, GOC:jl]", "GOBP_POSITIVE_REGULATION_OF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY": "", "GOBP_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY": "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. [GOC:BHF]", "GOBP_POSITIVE_REGULATION_OF_WOUND_HEALING": "", "GOBP_POSITIVE_REGULATION_OF_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS": "Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]", "GOBP_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY": "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_POSITIVE_THYMIC_T_CELL_SELECTION": "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. [ISBN:0781735149, PMID:12414722]", "GOBP_POSTREPLICATION_REPAIR": "", "GOBP_POSITIVE_T_CELL_SELECTION": "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. [ISBN:0781735149, PMID:12414722]", "GOBP_POSTSYNAPSE_TO_NUCLEUS_SIGNALING_PATHWAY": "The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). [GOC:dos, PMID:24317321, PMID:25652077]", "GOBP_POSTSYNAPSE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a postsynapse. [GOC:bf, GOC:dos, GOCL:PARL]", "GOBP_POSTSYNAPTIC_DENSITY_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. [GOC:BHF, GOC:sjp, PMID:21525273]", "GOBP_POSTSYNAPTIC_CYTOSKELETON_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. [GOC:dos]", "GOBP_POSTSYNAPTIC_MEMBRANE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). [GOC:BHF, GOC:sjp, PMID:21424692]", "GOBP_POSTSYNAPTIC_DENSITY_PROTEIN_95_CLUSTERING": "The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. [GOC:BHF, GOC:sjp, PMID:10433269]", "GOBP_POSTSYNAPSE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. [GOC:dos]", "GOBP_POSTSYNAPTIC_MODULATION_OF_CHEMICAL_SYNAPTIC_TRANSMISSION": "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. [GOC:dos]", "GOBP_POSTSYNAPTIC_MEMBRANE_ORGANIZATION": "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). [GOC:dph, GOC:pr]", "GOBP_POSTSYNAPTIC_SIGNAL_TRANSDUCTION": "Signal transduction in which the initial step occurs in a postsynapse. [GOC:dos]", "GOBP_POSTSYNAPTIC_NEUROTRANSMITTER_RECEPTOR_INTERNALIZATION": "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle. [GOC:dos]", "GOBP_POSTSYNAPTIC_SPECIALIZATION_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane. [GOC:dos]", "GOBP_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY": "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors. [PMID:10542094]", "GOBP_POST_ANAL_TAIL_MORPHOGENESIS": "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. [GOC:bf, GOC:kmv, Wikipedia:Chordate]", "GOBP_POSTSYNAPTIC_SPECIALIZATION_ORGANIZATION": "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane. [GOC:BHF, GOC:sjp, PMID:21525273, PMID:26834556]", "GOBP_POST_EMBRYONIC_ANIMAL_MORPHOGENESIS": "The process, occurring after animal embryonic development, by which anatomical structures are generated and organized. [GOC:go_curators]", "GOBP_POST_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT": "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. [GOC:mah, GOC:mtg_sensu]", "GOBP_POST_EMBRYONIC_EYE_MORPHOGENESIS": "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight. [GOC:jid, GOC:sensu]", "GOBP_POST_EMBRYONIC_DEVELOPMENT": "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. [GOC:go_curators]", "GOBP_POST_EMBRYONIC_HEMOPOIESIS": "The stages of blood cell formation that take place after completion of embryonic development. [GOC:bf]", "GOBP_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT": "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. [GOC:ai, GOC:mah]", "GOBP_POST_TRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE_TRANSLOCATION": "The process in which a protein translocates through the ER membrane posttranslationally. [PMID:12518317, PMID:8707814]", "GOBP_POTASSIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:11932440]", "GOBP_POST_TRANSLATIONAL_PROTEIN_TARGETING_TO_ENDOPLASMIC_RETICULUM_MEMBRANE": "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. [ISBN:0716731363]", "GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION": "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. [GOC:dph, GOC:tb]", "GOBP_POTASSIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]", "GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION": "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. [GOC:jsg]", "GOBP_PRENYLATION": "The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added. [GOC:di, PMID:18029206, PMID:21351751, PMID:22123822, PMID:22642693, PMID:22660767]", "GOBP_POTASSIUM_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. [GOC:jid, GOC:mah]", "GOBP_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE": "", "GOBP_PREPULSE_INHIBITION": "The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. [GOC:dph, PMID:10341260]", "GOBP_PRESYNAPTIC_ACTIVE_ZONE_ORGANIZATION": "A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone. [GOC:pr, PMID:16865347, PMID:17068967]", "GOBP_PRESYNAPSE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. [GOC:dos]", "GOBP_POTASSIUM_ION_TRANSPORT": "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_PRESYNAPTIC_MEMBRANE_ORGANIZATION": "A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. [GOC:BHF, GOC:pr, GOC:sjp, PMID:19730411]", "GOBP_PRE_MIRNA_PROCESSING": "A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. [GOC:sl, PMID:15211354]", "GOBP_PRIMARY_ALCOHOL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. [GOC:mah]", "GOBP_PRESYNAPTIC_MODULATION_OF_CHEMICAL_SYNAPTIC_TRANSMISSION": "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. [GOC:dos]", "GOBP_PRIMARY_ALCOHOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. [GOC:mah]", "GOBP_PRIMARY_ALCOHOL_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. [GOC:mah]", "GOBP_PRIMARY_MIRNA_PROCESSING": "A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. [GOC:sl, PMID:15211354, PMID:25799998]", "GOBP_PRIMARY_AMINO_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of primary amino compound. [GOC:TermGenie]", "GOBP_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS": "", "GOBP_PRIMITIVE_ERYTHROCYTE_DIFFERENTIATION": "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis. [GOC:add, GOC:BHF, GOC:dph]", "GOBP_PRIMITIVE_HEMOPOIESIS": "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells. [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]", "GOBP_PRIMITIVE_STREAK_FORMATION": "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_PROGESTERONE_METABOLIC_PROCESS": "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, PMID:11392024]", "GOBP_PROGESTERONE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, PMID:14613534]", "GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE": "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]", "GOBP_PROGRAMMED_CELL_DEATH_INVOLVED_IN_CELL_DEVELOPMENT": "The activation of endogenous cellular processes that result in the death of a cell as part of its development. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_PROGESTERONE_RECEPTOR_SIGNALING_PATHWAY": "A nuclear receptor-mediated signaling pathway initiated by a progesterone binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription. [PMID:14744870]", "GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE": "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_PROCESS_UTILIZING_AUTOPHAGIC_MECHANISM": "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway. [PMID:21997368, PMID:22966490, PMID:28596378]", "GOBP_PROLACTIN_SECRETION": "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary. [GOC:mah, ISBN:0198506732]", "GOBP_PROGRAMMED_CELL_DEATH_IN_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES": "Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:mtg_apoptosis]", "GOBP_PROLINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]", "GOBP_PROGRAMMED_NECROTIC_CELL_DEATH": "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. [GOC:mtg_apoptosis, PMID:21760595]", "GOBP_PROLINE_TRANSMEMBRANE_TRANSPORT": "The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore. [GOC:vw]", "GOBP_PROLINE_TRANSPORT": "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_PROPIONATE_METABOLIC_PROCESS": "", "GOBP_PRONEPHROS_DEVELOPMENT": "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151]", "GOBP_PROSTAGLANDIN_SECRETION": "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue. [GOC:mah]", "GOBP_PROPRIOCEPTION": "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors. [ISBN:072168677X]", "GOBP_PROSTAGLANDIN_TRANSPORT": "The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_PROSTANOID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. [GOC:ai]", "GOBP_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT": "The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. [GOC:dph, PMID:18977204]", "GOBP_PROSTATE_GLANDULAR_ACINUS_MORPHOGENESIS": "The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland. [GOC:dph]", "GOBP_PROSTANOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. [ISBN:0198506732]", "GOBP_PROSTATE_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. [PMID:11839751]", "GOBP_PROSTATE_GLAND_MORPHOGENESIS": "The process in which the anatomical structures of a prostate gland are generated and organized. [GOC:dph, PMID:18977204]", "GOBP_PROSTATE_GLAND_GROWTH": "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. [GOC:dph]", "GOBP_PROSTATIC_BUD_FORMATION": "The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. [GOC:dph, PMID:18977204]", "GOBP_PROSTHETIC_GROUP_METABOLIC_PROCESS": "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. [GOC:ai]", "GOBP_PROTEASOME_ASSEMBLY": "The aggregation, arrangement and bonding together of a mature, active proteasome complex. [GOC:go_curators, PMID:10872471]", "GOBP_PROTECTION_FROM_NON_HOMOLOGOUS_END_JOINING_AT_TELOMERE": "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse. [GOC:mah]", "GOBP_PROTECTION_FROM_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY": "The process of protecting a cell from natural killer cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]", "GOBP_PROTEIN_ACYLATION": "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. [GOC:jl]", "GOBP_PROTEIN_ACETYLATION": "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]", "GOBP_PROTEASOME_MEDIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:go_curators]", "GOBP_PROTEIN_ACTIVATION_CASCADE": "A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events. [GOC:add, GOC:mah, GOC:pde]", "GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. [GOC:tb]", "GOBP_PROTEIN_AUTOPROCESSING": "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. [GOC:ai, PMID:9335337]", "GOBP_PROTEIN_AUTOPHOSPHORYLATION": "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]", "GOBP_PROTEIN_AUTOUBIQUITINATION": "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. [GOC:ai]", "GOBP_PROTEIN_AUTO_ADP_RIBOSYLATION": "The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl]", "GOBP_PROTEIN_CATABOLIC_PROCESS_IN_THE_VACUOLE": "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. [GOC:mah, GOC:vw]", "GOBP_PROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]", "GOBP_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY": "", "GOBP_PROTEIN_DEGLUTAMYLATION": "The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation. [GOC:sp, PMID:21074048]", "GOBP_PROTEIN_C_LINKED_GLYCOSYLATION": "", "GOBP_PROTEIN_DEACETYLATION": "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]", "GOBP_PROTEIN_CONTAINING_COMPLEX_LOCALIZATION": "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. [GOC:mah]", "GOBP_PROTEIN_COMPLEX_OLIGOMERIZATION": "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai, PMID:18293929]", "GOBP_PROTEIN_CONTAINING_COMPLEX_REMODELING": "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. [GOC:BHF, GOC:mah, GOC:mtg_mpo, GOC:rl]", "GOBP_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY": "The disaggregation of a protein-containing macromolecular complex into its constituent components. [GOC:mah]", "GOBP_PROTEIN_DEGLYCOSYLATION": "The removal of sugar residues from a glycosylated protein. [GOC:mah]", "GOBP_PROTEIN_DENEDDYLATION": "The removal of a ubiquitin-like protein of the NEDD8 type from a protein. [GOC:krc]", "GOBP_PROTEIN_DELIPIDATION": "The breakage of covalent bonds to detach lipid groups from a protein. [GOC:ai]", "GOBP_PROTEIN_DEMETHYLATION": "", "GOBP_PROTEIN_DEPALMITOYLATION": "The removal of palymitoyl groups from a lipoprotein. [GOC:hjd]", "GOBP_PROTEIN_DESUMOYLATION": "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. [GOC:jl, PMID:11265250]", "GOBP_PROTEIN_DEPHOSPHORYLATION": "The process of removing one or more phosphoric residues from a protein. [GOC:hb]", "GOBP_PROTEIN_DESTABILIZATION": "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. [GOC:mah]", "GOBP_PROTEIN_DEUBIQUITINATION": "", "GOBP_PROTEIN_DEUBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism. [GOC:mah]", "GOBP_PROTEIN_DEPOLYMERIZATION": "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. [GOC:ai]", "GOBP_PROTEIN_DE_ADP_RIBOSYLATION": "The process of removing one or more ADP-ribose residues from a protein. [GOC:ai]", "GOBP_PROTEIN_DNA_COMPLEX_DISASSEMBLY": "The disaggregation of a protein-DNA complex into its constituent components. [GOC:mah]", "GOBP_PROTEIN_DNA_COMPLEX_ASSEMBLY": "", "GOBP_PROTEIN_DNA_COVALENT_CROSS_LINKING_REPAIR": "The removal of covalent cross-link between DNA and a protein. [PMID:31921408]", "GOBP_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM": "The directed movement of proteins from the endoplasmic reticulum. [GOC:rb]", "GOBP_PROTEIN_EXPORT_FROM_NUCLEUS": "The directed movement of a protein from the nucleus into the cytoplasm. [GOC:jl]", "GOBP_PROTEIN_DNA_COMPLEX_ORGANIZATION": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. [GOC:mah]", "GOBP_PROTEIN_HETEROOLIGOMERIZATION": "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai]", "GOBP_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM": "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). [GOC:mah, GOC:vw]", "GOBP_PROTEIN_GERANYLGERANYLATION": "The covalent attachment of a geranylgeranyl group to a protein. [GOC:jl]", "GOBP_PROTEIN_HEXAMERIZATION": "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. [GOC:ecd]", "GOBP_PROTEIN_HISTIDYL_MODIFICATION_TO_DIPHTHAMIDE": "", "GOBP_PROTEIN_HETEROTETRAMERIZATION": "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. [GOC:go_curators]", "GOBP_PROTEIN_FOLDING": "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb]", "GOBP_PROTEIN_HYDROXYLATION": "The addition of a hydroxy group to a protein amino acid. [GOC:ai]", "GOBP_PROTEIN_HOMOTETRAMERIZATION": "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators]", "GOBP_PROTEIN_HOMOOLIGOMERIZATION": "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai]", "GOBP_PROTEIN_IMPORT": "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. [GOC:ai]", "GOBP_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX": "", "GOBP_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX": "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. [ISBN:0716731363]", "GOBP_PROTEIN_IMPORT_INTO_PEROXISOME_MEMBRANE": "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import. [ISBN:0716731363, PMID:11687502]", "GOBP_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX_RECEPTOR_RECYCLING": "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol. [PMID:11687502]", "GOBP_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX_SUBSTRATE_RELEASE": "The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane. [PMID:21976670]", "GOBP_PROTEIN_INSERTION_INTO_ER_MEMBRANE": "The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. [ISBN:0716731363]", "GOBP_PROTEIN_INSERTION_INTO_ER_MEMBRANE_BY_STOP_TRANSFER_MEMBRANE_ANCHOR_SEQUENCE": "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix. [ISBN:0716731363]", "GOBP_PROTEIN_INSERTION_INTO_MEMBRANE": "The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. [GOC:ai]", "GOBP_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_INNER_MEMBRANE": "The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane. [GOC:mcc, GOC:vw, PMID:18672008]", "GOBP_PROTEIN_INSERTION_INTO_MEMBRANE_FROM_INNER_SIDE": "", "GOBP_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE": "", "GOBP_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_OUTER_MEMBRANE": "", "GOBP_PROTEIN_K27_LINKED_UBIQUITINATION": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein. [PMID:19345326]", "GOBP_PROTEIN_K11_LINKED_DEUBIQUITINATION": "A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein. [GOC:sp, PMID:21596315]", "GOBP_PROTEIN_K29_LINKED_DEUBIQUITINATION": "", "GOBP_PROTEIN_K11_LINKED_UBIQUITINATION": "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]", "GOBP_PROTEIN_K29_LINKED_UBIQUITINATION": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation. [PMID:17028573]", "GOBP_PROTEIN_K48_LINKED_DEUBIQUITINATION": "A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. [GOC:mah]", "GOBP_PROTEIN_K48_LINKED_UBIQUITINATION": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. [GOC:cvs, PMID:15556404]", "GOBP_PROTEIN_K63_LINKED_DEUBIQUITINATION": "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. [GOC:mah, PMID:19202061, PMID:19214193]", "GOBP_PROTEIN_K6_LINKED_UBIQUITINATION": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair. [GOC:sp]", "GOBP_PROTEIN_KINASE_A_SIGNALING": "", "GOBP_PROTEIN_K63_LINKED_UBIQUITINATION": "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. [GOC:mah, PMID:15556404]", "GOBP_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_PROTEIN_KINASE_C_SIGNALING": "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. [GOC:BHF, GOC:mah]", "GOBP_PROTEIN_LIPID_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. [GOC:jl]", "GOBP_PROTEIN_LINEAR_POLYUBIQUITINATION": "A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein. [GOC:jsg, GOC:sp, PMID:21455173, PMID:21455180, PMID:21455181, PMID:31998699]", "GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. [GOC:mah]", "GOBP_PROTEIN_LIPOYLATION": "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. [RESID:AA0118]", "GOBP_PROTEIN_LOCALIZATION_TO_ADHERENS_JUNCTION": "Any process in which a protein is transported to, and/or maintained at the adherens junction. [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237]", "GOBP_PROTEIN_LOCALIZATION_TO_AXON": "A process in which a protein is transported to or maintained in a location within an axon. [GOC:dos, PMID:26157139]", "GOBP_PROTEIN_LOCALIZATION_TO_BICELLULAR_TIGHT_JUNCTION": "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction. [GOC:TermGenie, PMID:18332111]", "GOBP_PROTEIN_LOCALIZATION_TO_CELL_CORTEX": "A process in which a protein is transported to, or maintained in, the cell cortex. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_CELL_CELL_JUNCTION": "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. [GOC:aruk, GOC:bc, PMID:26706435]", "GOBP_PROTEIN_LOCALIZATION_TO_BASOLATERAL_PLASMA_MEMBRANE": "", "GOBP_PROTEIN_LOCALIZATION_TO_CELL_LEADING_EDGE": "A process in which a protein is transported to, or maintained in, a location within a cell leading edge. [GOC:lb, GOC:TermGenie, PMID:21543326]", "GOBP_PROTEIN_LOCALIZATION_TO_CELL_JUNCTION": "A process in which a protein is transported to, or maintained in, a location within a cell junction. [GOC:TermGenie, PMID:18332111]", "GOBP_PROTEIN_LOCALIZATION_TO_CENP_A_CONTAINING_CHROMATIN": "Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin. [GOC:dph, GOC:vw]", "GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE": "A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_CHROMATIN": "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY": "A process in which a protein is transported to, or maintained in, the cell periphery. [PMID:18216290]", "GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION": "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. [GOC:BHF, GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION": "Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_CILIARY_MEMBRANE": "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371]", "GOBP_PROTEIN_LOCALIZATION_TO_CILIARY_TRANSITION_ZONE": "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230]", "GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME": "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_CONDENSED_CHROMOSOME": "A process in which a protein is transported to, or maintained in, a location within a condensed chromosome. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:12707312]", "GOBP_PROTEIN_LOCALIZATION_TO_CYTOPLASMIC_STRESS_GRANULE": "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule. [GO_REF:0000087, GOC:TermGenie, PMID:24755092]", "GOBP_PROTEIN_LOCALIZATION_TO_CILIUM": "A process in which a protein is transported to, or maintained in, a location within a cilium. [GOC:dph]", "GOBP_PROTEIN_LOCALIZATION_TO_CYTOSKELETON": "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. [GOC:jl]", "GOBP_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM_EXIT_SITE": "A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_EARLY_ENDOSOME": "A process in which a protein is transported to, or maintained in, a location within an early endosome. [GO_REF:0000087, GOC:sjp, GOC:TermGenie, PMID:22621900]", "GOBP_PROTEIN_LOCALIZATION_TO_ENDOSOME": "A process in which a protein is transported to, or maintained in, a location within an endosome. [GOC:yaf]", "GOBP_PROTEIN_LOCALIZATION_TO_GOLGI_MEMBRANE": "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. [GO_REF:0000087, GOC:TermGenie, PMID:11378902]", "GOBP_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM": "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_MEMBRANE_RAFT": "A process in which a protein is transported to, or maintained in, a location within a membrane raft. [GO_REF:0000087, GOC:dl, GOC:TermGenie, PMID:19414744]", "GOBP_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS": "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION": "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_LYSOSOME": "A process in which a protein is transported to, or maintained in, a location within a lysosome. [GOC:dph]", "GOBP_PROTEIN_LOCALIZATION_TO_MICROTUBULE": "A process in which a protein is transported to, or maintained at, a microtubule. [GOC:bf, GOC:lb]", "GOBP_PROTEIN_LOCALIZATION_TO_MICROTUBULE_ORGANIZING_CENTER": "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center. [GO_REF:0000087, GOC:TermGenie, PMID:19001497]", "GOBP_PROTEIN_LOCALIZATION_TO_MITOCHONDRION": "A process in which a protein is transported to, or maintained in, a location within the mitochondrion. [GOC:ecd]", "GOBP_PROTEIN_LOCALIZATION_TO_MOTILE_CILIUM": "A process in which a protein is transported to, or maintained in, a location within a motile cilium. [GOC:krc, PMID:27486780]", "GOBP_PROTEIN_LOCALIZATION_TO_NON_MOTILE_CILIUM": "A process in which a protein is transported to, or maintained in, a location within a non-motile cilium. [GOC:cilia, GOC:kmv, PMID:23128241]", "GOBP_PROTEIN_LOCALIZATION_TO_NUCLEAR_BODY": "", "GOBP_PROTEIN_LOCALIZATION_TO_NUCLEOLUS": "A process in which a protein is transported to, or maintained in, a location within a nucleolus. [GOC:TermGenie, PMID:22809626]", "GOBP_PROTEIN_LOCALIZATION_TO_NUCLEAR_ENVELOPE": "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. [GOC:tb]", "GOBP_PROTEIN_LOCALIZATION_TO_NUCLEOPLASM": "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm. [GOC:mah, PMID:22918952]", "GOBP_PROTEIN_LOCALIZATION_TO_PERINUCLEAR_REGION_OF_CYTOPLASM": "A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm. [GO_REF:0000087, GOC:TermGenie, PMID:15177031]", "GOBP_PROTEIN_LOCALIZATION_TO_PHOTORECEPTOR_OUTER_SEGMENT": "A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment. [GO_REF:0000087, GOC:TermGenie, PMID:11481257, PMID:21867699]", "GOBP_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE_RAFT": "A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft. [GOC:jl]", "GOBP_PROTEIN_LOCALIZATION_TO_PHAGOPHORE_ASSEMBLY_SITE": "Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS). [GOC:rb]", "GOBP_PROTEIN_LOCALIZATION_TO_NUCLEUS": "A process in which a protein transports or maintains the localization of another protein to the nucleus. [GOC:ecd]", "GOBP_PROTEIN_LOCALIZATION_TO_PRESYNAPSE": "A process in which a protein is transported to, or maintained in, a location within a presynapse. [GO_REF:0000087, GOC:TermGenie, PMID:24449494]", "GOBP_PROTEIN_LOCALIZATION_TO_POSTSYNAPSE": "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. [PMID:31189538]", "GOBP_PROTEIN_LOCALIZATION_TO_SITE_OF_DOUBLE_STRAND_BREAK": "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred. [GOC:mah, PMID:23080121]", "GOBP_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE": "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE": "A process in which a protein is transported to, or maintained in, a location within an organelle. [GOC:mah]", "GOBP_PROTEIN_LOCALIZATION_TO_SYNAPSE": "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:bf]", "GOBP_PROTEIN_MATURATION_BY_4FE_4S_CLUSTER_TRANSFER": "", "GOBP_PROTEIN_MATURATION_BY_IRON_SULFUR_CLUSTER_TRANSFER": "", "GOBP_PROTEIN_LOCALIZATION_TO_VACUOLE": "A process in which a protein is transported to, or maintained at, a location in a vacuole. [GOC:ecd]", "GOBP_PROTEIN_MATURATION_BY_PROTEIN_FOLDING": "", "GOBP_PROTEIN_MATURATION": "Any process leading to the attainment of the full functional capacity of a protein. [GOC:ai]", "GOBP_PROTEIN_METHYLATION": "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. [GOC:ai]", "GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL": "A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. [GOC:mah]", "GOBP_PROTEIN_NITROSYLATION": "", "GOBP_PROTEIN_NEDDYLATION": "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. [PMID:11698580]", "GOBP_PROTEIN_N_LINKED_GLYCOSYLATION_VIA_ASPARAGINE": "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. [GOC:jsg]", "GOBP_PROTEIN_OXIDATION": "The modification of a protein amino acid by oxidation. [GOC:ai]", "GOBP_PROTEIN_MONOUBIQUITINATION": "Addition of a single ubiquitin group to a protein. [GOC:ai]", "GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION": "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. [GOC:mah]", "GOBP_PROTEIN_N_LINKED_GLYCOSYLATION": "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of an asparagine residue. [PMID:35536965]", "GOBP_PROTEIN_O_LINKED_FUCOSYLATION": "", "GOBP_PROTEIN_O_LINKED_GLYCOSYLATION_VIA_SERINE": "", "GOBP_PROTEIN_O_LINKED_GLYCOSYLATION_VIA_THREONINE": "", "GOBP_PROTEIN_O_LINKED_GLYCOSYLATION": "A glycoprotein biosynthetic process starting with the covalent linkage of carbohydrate or carbohydrate derivative unit via a glycosidic bond to the oxygen atom of a serine, threonine, hydroxylysine, hydroxyproline or tyrosine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan. [PMID:33775405]", "GOBP_PROTEIN_O_LINKED_MANNOSYLATION": "", "GOBP_PROTEIN_PALMITOYLATION": "The covalent attachment of a palmitoyl group to a protein. [GOC:jl, PMID:15520806]", "GOBP_PROTEIN_POLYGLUTAMYLATION": "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. [RESID:AA0202]", "GOBP_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION": "", "GOBP_PROTEIN_POLYUFMYLATION": "Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain. [PMID:25219498]", "GOBP_PROTEIN_POLY_ADP_RIBOSYLATION": "The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]", "GOBP_PROTEIN_POLYUBIQUITINATION": "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. [PMID:26906419]", "GOBP_PROTEIN_PROCESSING_INVOLVED_IN_PROTEIN_TARGETING_TO_MITOCHONDRION": "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. [GOC:mcc, PMID:12191769]", "GOBP_PROTEIN_POLYMERIZATION": "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. [GOC:ai]", "GOBP_PROTEIN_REFOLDING": "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. [GOC:mb]", "GOBP_PROTEIN_QUALITY_CONTROL_FOR_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEINS": "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. [GOC:jl]", "GOBP_PROTEIN_RETENTION_IN_ER_LUMEN": "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. [ISBN:0716731363, PMID:12972550]", "GOBP_PROTEIN_REPAIR": "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. [GOC:mlg]", "GOBP_PROTEIN_PROCESSING": "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]", "GOBP_PROTEIN_RETENTION_IN_GOLGI_APPARATUS": "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known. [ISBN:0716731363]", "GOBP_PROTEIN_RNA_COMPLEX_DISASSEMBLY": "The disaggregation of a protein-RNA complex into its constituent components. [GOC:mah]", "GOBP_PROTEIN_SIDE_CHAIN_DEGLUTAMYLATION": "", "GOBP_PROTEIN_SULFATION": "The addition of a sulfate group as an ester to a protein amino acid. [GOC:curators]", "GOBP_PROTEIN_STABILIZATION": "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]", "GOBP_PROTEIN_SUMOYLATION": "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. [GOC:jl, PMID:11265250]", "GOBP_PROTEIN_TARGETING_TO_LYSOSOME": "The process of directing proteins towards the lysosome using signals contained within the protein. [GOC:curators]", "GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION": "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. [GOC:mah]", "GOBP_PROTEIN_TARGETING_TO_PEROXISOME": "The process of directing proteins towards the peroxisome, usually using signals contained within the protein. [GOC:ai]", "GOBP_PROTEIN_TARGETING_TO_MEMBRANE": "The process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:curators]", "GOBP_PROTEIN_TARGETING_TO_MITOCHONDRION": "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. [GOC:mcc, ISBN:0716731363]", "GOBP_PROTEIN_TARGETING": "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. [GOC:ma]", "GOBP_PROTEIN_TARGETING_TO_VACUOLE_INVOLVED_IN_AUTOPHAGY": "The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm. [GOC:mah]", "GOBP_PROTEIN_TARGETING_TO_VACUOLE": "The process of directing proteins towards the vacuole, usually using signals contained within the protein. [GOC:curators]", "GOBP_PROTEIN_TO_MEMBRANE_DOCKING": "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere. [GOC:isa_complete]", "GOBP_PROTEIN_TETRAMERIZATION": "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. [GOC:ecd]", "GOBP_PROTEIN_TRANSPORT_INTO_MEMBRANE_RAFT": "The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. [GOC:mah]", "GOBP_PROTEIN_TRANSMEMBRANE_IMPORT_INTO_INTRACELLULAR_ORGANELLE": "The directed movement of proteins into an intracellular organelle, across a membrane. [GOC:jl]", "GOBP_PROTEIN_TRANSMEMBRANE_TRANSPORT": "The process in which a protein is transported across a membrane. [GOC:mah, GOC:vw]", "GOBP_PROTEIN_TRANSPORT_WITHIN_LIPID_BILAYER": "The directed movement of a protein from one location to another within a lipid bilayer. [GOC:mah]", "GOBP_PROTEIN_TRANSPORT_TO_VACUOLE_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY": "The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. [GOC:jl, PMID:11511343]", "GOBP_PROTEIN_TRIMERIZATION": "The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. [GOC:hjd]", "GOBP_PROTEIN_UFMYLATION": "Covalent attachment of the ubiquitin-like protein UFM1 to another protein. [GOC:vw, PMID:20018847]", "GOBP_PROTEIN_UNFOLDING": "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. [GOC:mlg]", "GOBP_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [PMID:35536939]", "GOBP_PROTEIN_TRANSPORT": "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_PROTEOGLYCAN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [PMID:35536982]", "GOBP_PROTEOGLYCAN_METABOLIC_PROCESS": "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [PMID:35536939]", "GOBP_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. [GOC:mah]", "GOBP_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. [GOC:mah]", "GOBP_PROTOPORPHYRINOGEN_IX_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. [GOC:go_curators]", "GOBP_PROTON_MOTIVE_FORCE_DRIVEN_ATP_SYNTHESIS": "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). [GOC:vw]", "GOBP_PROTOPORPHYRINOGEN_IX_METABOLIC_PROCESS": "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation. [ISBN:0198506732]", "GOBP_PROTON_TRANSMEMBRANE_TRANSPORT": "The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]", "GOBP_PROXIMAL_DISTAL_PATTERN_FORMATION_INVOLVED_IN_NEPHRON_DEVELOPMENT": "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end). [GOC:mtg_kidney_jan10]", "GOBP_PROTEOLYSIS": "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]", "GOBP_PROXIMAL_DISTAL_PATTERN_FORMATION": "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). [GOC:dph, GOC:go_curators, GOC:isa_complete]", "GOBP_PROXIMAL_TUBULE_DEVELOPMENT": "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology. [GOC:mtg_kidney_jan10]", "GOBP_PRO_B_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed. [GOC:jal, ISBN:0781735149]", "GOBP_PROTEOLYSIS_INVOLVED_IN_PROTEIN_CATABOLIC_PROCESS": "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_PSEUDOPODIUM_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. [GOC:pg]", "GOBP_PSEUDOURIDINE_SYNTHESIS": "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. [GOC:hjd, GOC:mah]", "GOBP_PSYCHOMOTOR_BEHAVIOR": "The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument. [GOC:nhn, GOC:pr, PMID:17159989, Wikipedia:Psychomotor_learning]", "GOBP_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. [GOC:jl, ISBN:0198506732]", "GOBP_PULMONARY_ARTERY_MORPHOGENESIS": "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. [GOC:dph, GOC:yaf]", "GOBP_PULMONARY_VALVE_DEVELOPMENT": "The progression of the pulmonary valve over time, from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_PULMONARY_VALVE_MORPHOGENESIS": "The process in which the structure of the pulmonary valve is generated and organized. [GOC:mtg_heart]", "GOBP_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. [GOC:jl, ISBN:0198506732]", "GOBP_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, PMID:9755289]", "GOBP_PURINE_CONTAINING_COMPOUND_SALVAGE": "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. [GOC:jl]", "GOBP_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. [GOC:mah]", "GOBP_PURINE_DEOXYRIBONUCLEOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]", "GOBP_PURINE_DEOXYRIBONUCLEOSIDE_MONOPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_DEOXYRIBONUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT": "The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof. [GOC:mah]", "GOBP_PURINE_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. [GOC:mah]", "GOBP_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_DEOXYRIBONUCLEOTIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_NUCLEOBASE_METABOLIC_PROCESS": "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. [GOC:go_curators]", "GOBP_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. [ISBN:0198506732]", "GOBP_PURINE_NUCLEOBASE_TRANSMEMBRANE_TRANSPORT": "The process in which a purine nucleobase is transported across a membrane. [GO_REF:0000069, GOC:TermGenie]", "GOBP_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:go_curators]", "GOBP_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:go_curators]", "GOBP_PURINE_NUCLEOSIDE_DIPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_NUCLEOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:jl, ISBN:0140512713]", "GOBP_PURINE_NUCLEOSIDE_MONOPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT": "The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. [GOC:ai, GOC:vw]", "GOBP_PURINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:ai]", "GOBP_PURINE_NUCLEOTIDE_SALVAGE": "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis. [GOC:jp]", "GOBP_PURINE_RIBONUCLEOSIDE_METABOLIC_PROCESS": "", "GOBP_PURINE_RIBONUCLEOTIDE_SALVAGE": "Any process which produces a purine ribonucleotide from derivatives of it, without de novo synthesis. [PMID:8864750]", "GOBP_PURINE_NUCLEOTIDE_TRANSPORT": "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. [GOC:ai]", "GOBP_PURINE_RIBONUCLEOSIDE_SALVAGE": "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. [GOC:jl]", "GOBP_PURKINJE_MYOCYTE_TO_VENTRICULAR_CARDIAC_MUSCLE_CELL_COMMUNICATION": "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_PUTRESCINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine. [GOC:ai]", "GOBP_PUTRESCINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRAMIDAL_NEURON_DEVELOPMENT": "The progression of a pyramidal neuron from its initial formation to its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_PYRAMIDAL_NEURON_DIFFERENTIATION": "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. [GOC:mah]", "GOBP_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS": "", "GOBP_PYRIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. [GOC:mah]", "GOBP_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]", "GOBP_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE": "Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. [GOC:jl]", "GOBP_PYRIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. [GOC:mah]", "GOBP_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT": "The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]", "GOBP_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]", "GOBP_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]", "GOBP_PYRIMIDINE_DEOXYRIBONUCLEOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). [GOC:ai]", "GOBP_PYRIMIDINE_DEOXYRIBONUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_DIMER_REPAIR": "The repair of UV-induced T-T, C-T and C-C dimers. [ISBN:0815316194]", "GOBP_PYRIMIDINE_NUCLEOBASE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. [GOC:go_curators]", "GOBP_PYRIMIDINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. [GOC:go_curators]", "GOBP_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. [GOC:go_curators]", "GOBP_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:ai]", "GOBP_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS": "", "GOBP_PYRIMIDINE_NUCLEOSIDE_DIPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:jl, ISBN:0140512713]", "GOBP_PYRIMIDINE_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS": "", "GOBP_PYRIMIDINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_RIBONUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_RIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRIMIDINE_RIBONUCLEOTIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYROPTOSIS": "", "GOBP_PYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS": "", "GOBP_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_PYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS": "", "GOBP_PYRUVATE_TRANSPORT": "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_PYRUVATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. [GOC:go_curators]", "GOBP_P_BODY_ASSEMBLY": "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. [GOC:mah, PMID:17429074]", "GOBP_QUINOLINATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. [GOC:ai]", "GOBP_QUATERNARY_AMMONIUM_GROUP_TRANSPORT": "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [GOC:ai, ISBN:0198506732]", "GOBP_QUINONE_METABOLIC_PROCESS": "The chemical reactions and pathways involving quinone. [GOC:go_curators, GOC:pr, GOC:TermGenie]", "GOBP_RAB_PROTEIN_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal. [GOC:mah]", "GOBP_RADIAL_GLIAL_CELL_DIFFERENTIATION": "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph]", "GOBP_RAC_PROTEIN_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette in which a small monomeric GTPase of the Rac subfamily relays a signal. [GOC:bf]", "GOBP_RADIAL_GLIA_GUIDED_PYRAMIDAL_NEURON_MIGRATION": "", "GOBP_RANDOM_INACTIVATION_OF_X_CHROMOSOME": "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex. [GOC:dph, GOC:sdb_2009, GOC:tb, PMID:32189388]", "GOBP_RAP_PROTEIN_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette in which a small monomeric GTPase of the Rap subfamily relays a signal. [GOC:mah]", "GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]", "GOBP_REACTIVE_GLIOSIS": "A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells. [GOC:aruk, GOC:bc, PMID:24462092]", "GOBP_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS": "The chemical reactions and pathways involving a reactive nitrogen species. [GOC:obol]", "GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]", "GOBP_RECEPTOR_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:mah]", "GOBP_RECEPTOR_DIFFUSION_TRAPPING": "The process by which a membrane receptor, diffusing freely within the plasma membeane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix. [PMID:18832033]", "GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS": "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. [GOC:mah]", "GOBP_RECEPTOR_GUANYLYL_CYCLASE_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and converts GTP to cGMP upon activation, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:16815030]", "GOBP_RECEPTOR_CLUSTERING": "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]", "GOBP_RECEPTOR_LOCALIZATION_TO_NON_MOTILE_CILIUM": "A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium. [GOC:cilia, GOC:kmv, PMID:23128241]", "GOBP_RECEPTOR_INTERNALIZATION": "A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]", "GOBP_RECEPTOR_LOCALIZATION_TO_SYNAPSE": "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:BHF, GOC:sjp, PMID:21525273]", "GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS_OF_VIRUS_BY_HOST_CELL": "Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell. [GOC:bf, GOC:jl, ISBN:0781702534]", "GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS_INVOLVED_IN_CHOLESTEROL_TRANSPORT": "A receptor-mediated endocytosis process involved in intracellular cholesterol transport. [GOC:ascb_2009, GOC:dph, GOC:pr, GOC:tb]", "GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS": "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. [GOC:mah, ISBN:0716731363]", "GOBP_RECEPTOR_MEDIATED_VIRION_ATTACHMENT_TO_HOST_CELL": "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface. [ISBN:0879694971]", "GOBP_RECOGNITION_OF_APOPTOTIC_CELL": "The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis. [GOC:rk, PMID:15536015]", "GOBP_RECEPTOR_METABOLIC_PROCESS": "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:jl]", "GOBP_REDUCTION_OF_FOOD_INTAKE_IN_RESPONSE_TO_DIETARY_EXCESS": "An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients. [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200]", "GOBP_RECEPTOR_RECYCLING": "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal. [GOC:dph]", "GOBP_REELIN_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:12827279, PMID:20223215]", "GOBP_REFLEX": "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. [GOC:dph, ISBN:0877797099]", "GOBP_RECOMBINATIONAL_REPAIR": "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. [GOC:elh]", "GOBP_REGULATED_EXOCYTOSIS": "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. [GOC:mah, ISBN:0716731363]", "GOBP_REGENERATION": "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass). [GOC:mah, GOC:pr]", "GOBP_REGULATION_OF_3_UTR_MEDIATED_MRNA_STABILIZATION": "Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization. [GO_REF:0000058, GOC:TermGenie, PMID:19737525]", "GOBP_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL": "Any virus-mediated process that modulates the levels of viral proteins in a cell. [GOC:ai]", "GOBP_REGULATION_OF_ACROSOME_REACTION": "Any process that modulates the frequency, rate or extent of the acrosome reaction. [GOC:dph]", "GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT": "Any process that modulates the frequency, rate or extent of actin filament-based movement. [GO_REF:0000058, GOC:TermGenie, PMID:24798735]", "GOBP_REGULATION_OF_ACTIN_FILAMENT_LENGTH": "Any process that controls the length of actin filaments in a cell. [GOC:dph, GOC:mah]", "GOBP_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY": "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. [GOC:mah]", "GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS": "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. [GOC:mah]", "GOBP_REGULATION_OF_ACTIN_FILAMENT_ORGANIZATION": "Any process that modulates the frequency, rate or extent of actin filament organization. [GOC:kmv]", "GOBP_REGULATION_OF_ACTION_POTENTIAL": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]", "GOBP_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl]", "GOBP_REGULATION_OF_ACTIN_NUCLEATION": "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. [GOC:ai]", "GOBP_REGULATION_OF_ACTIVATION_OF_JANUS_KINASE_ACTIVITY": "", "GOBP_REGULATION_OF_ACTOMYOSIN_STRUCTURE_ORGANIZATION": "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. [GOC:lf, PMID:22790195]", "GOBP_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. [GOC:ai]", "GOBP_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE": "Any process that modulates the frequency, rate, or extent of an acute inflammatory response. [GOC:add]", "GOBP_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS": "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add]", "GOBP_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]", "GOBP_REGULATION_OF_ADIPOSE_TISSUE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]", "GOBP_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]", "GOBP_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION": "Any process that modulates the frequency, rate or extent of adherens junction organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]", "GOBP_REGULATION_OF_ADIPONECTIN_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell. [GOC:mah]", "GOBP_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate, or extent of an adaptive immune response. [GOC:add]", "GOBP_REGULATION_OF_AEROBIC_RESPIRATION": "Any process that modulates the frequency, rate or extent of aerobic respiration. [GO_REF:0000058, GOC:TermGenie, PMID:19266076]", "GOBP_REGULATION_OF_AGGREPHAGY": "Any process that modulates the frequency, rate or extent of aggrephagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]", "GOBP_REGULATION_OF_ALDOSTERONE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. [GOC:mah]", "GOBP_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]", "GOBP_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. [GOC:ai]", "GOBP_REGULATION_OF_AMACRINE_CELL_DIFFERENTIATION": "", "GOBP_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. [GOC:ai]", "GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. [GOC:mah]", "GOBP_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME": "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. [GOC:krc]", "GOBP_REGULATION_OF_AMINE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. [GOC:mah]", "GOBP_REGULATION_OF_AMINO_ACID_TRANSMEMBRANE_TRANSPORT": "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport. [GO_REF:0000058, GOC:TermGenie, PMID:16115814]", "GOBP_REGULATION_OF_AMYLOID_BETA_CLEARANCE": "Any process that modulates the frequency, rate or extent of amyloid-beta clearance. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_AMINO_ACID_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_REGULATION_OF_AMPA_RECEPTOR_ACTIVITY": "Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity. [GOC:BHF]", "GOBP_REGULATION_OF_AMYLOID_FIBRIL_FORMATION": "Any process that modulates the frequency, rate or extent of amyloid fibril formation. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]", "GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]", "GOBP_REGULATION_OF_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10921876]", "GOBP_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph]", "GOBP_REGULATION_OF_ANIMAL_ORGAN_FORMATION": "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. [GOC:dph, GOC:mtg_heart, GOC:tb]", "GOBP_REGULATION_OF_ANGIOTENSIN_LEVELS_IN_BLOOD": "The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation. [GOC:rl, PMID:21951628, Wikipedia:Angiotensin]", "GOBP_REGULATION_OF_ANION_CHANNEL_ACTIVITY": "", "GOBP_REGULATION_OF_ANOIKIS": "Any process that modulates the frequency, rate or extent of anoikis. [GOC:mah]", "GOBP_REGULATION_OF_ANIMAL_ORGAN_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of animal organ morphogenesis. [GOC:obol]", "GOBP_REGULATION_OF_ANTIBACTERIAL_PEPTIDE_PRODUCTION": "", "GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE": "Any process that modulates the size of an anatomical structure. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_ANTIFUNGAL_INNATE_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate or extent of an antifungal innate immune response. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487]", "GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. [GOC:mah]", "GOBP_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation. [GOC:add]", "GOBP_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. [GOC:add]", "GOBP_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN": "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. [GOC:add]", "GOBP_REGULATION_OF_ANTIMICROBIAL_HUMORAL_RESPONSE": "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response. [GOC:add]", "GOBP_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. [GOC:ai]", "GOBP_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE": "Any process that modulates the frequency, rate or extent of apoptotic cell clearance. [GOC:obol]", "GOBP_REGULATION_OF_ANTIMICROBIAL_PEPTIDE_PRODUCTION": "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production. [GOC:add]", "GOBP_REGULATION_OF_APOPTOTIC_DNA_FRAGMENTATION": "", "GOBP_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of apoptotic process involved in development. [GO_REF:0000058, GOC:TermGenie, PMID:22801495]", "GOBP_REGULATION_OF_APOPTOTIC_PROCESS_IN_BONE_MARROW_CELL": "Any process that modulates the occurrence or rate of cell death by apoptotic process in the bone marrow. [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141]", "GOBP_REGULATION_OF_APPETITE": "Any process which modulates appetite, the desire or physical craving for food. [GOC:add]", "GOBP_REGULATION_OF_ARACHIDONIC_ACID_SECRETION": "", "GOBP_REGULATION_OF_ARTERY_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of artery morphogenesis. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]", "GOBP_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION": "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. [GOC:mah]", "GOBP_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY": "", "GOBP_REGULATION_OF_ASTROCYTE_ACTIVATION": "Any process that modulates the frequency, rate or extent of astrocyte activation. [GOC:aruk, GOC:bc, PMID:20005821]", "GOBP_REGULATION_OF_ASTROCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of astrocyte differentiation. [GOC:vp, PMID:15139015]", "GOBP_REGULATION_OF_ASPARTIC_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS": "", "GOBP_REGULATION_OF_ATPASE_COUPLED_CALCIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Any process that modulates the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]", "GOBP_REGULATION_OF_ASYMMETRIC_CELL_DIVISION": "Any process that modulates the frequency, rate or extent of asymmetric cell division. [GOC:lr]", "GOBP_REGULATION_OF_ATP_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]", "GOBP_REGULATION_OF_ATP_DEPENDENT_ACTIVITY": "Any process that modulates the rate of an ATP-dependent activity. [GOC:jl]", "GOBP_REGULATION_OF_ATP_METABOLIC_PROCESS": "", "GOBP_REGULATION_OF_ATRIAL_CARDIAC_MUSCLE_CELL_MEMBRANE_DEPOLARIZATION": "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_ATRIAL_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION": "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_ATTACHMENT_OF_MITOTIC_SPINDLE_MICROTUBULES_TO_KINETOCHORE": "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. [GOC:TermGenie, GOC:vw, PMID:22065639]", "GOBP_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE": "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. [GOC:ai]", "GOBP_REGULATION_OF_AUTOPHAGOSOME_MATURATION": "Any process that modulates the frequency, rate or extent of autophagosome maturation. [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]", "GOBP_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION": "", "GOBP_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY": "Any process that modulates the frequency, rate or extent of autophagosome assembly. [GOC:autophagy, GOC:BHF]", "GOBP_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION": "Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process. [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]", "GOBP_REGULATION_OF_AUTOPHAGY": "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE": "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. [GOC:devbiol]", "GOBP_REGULATION_OF_AXON_GUIDANCE": "Any process that modulates the frequency, rate or extent of axon guidance. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775]", "GOBP_REGULATION_OF_AXON_EXTENSION": "Any process that modulates the rate, direction or extent of axon extension. [GOC:go_curators]", "GOBP_REGULATION_OF_BARBED_END_ACTIN_FILAMENT_CAPPING": "Any process that modulates the frequency, rate or extent of barbed-end actin filament capping. [GOC:BHF]", "GOBP_REGULATION_OF_AXONOGENESIS": "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. [GOC:ai]", "GOBP_REGULATION_OF_BASEMENT_MEMBRANE_ORGANIZATION": "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. [GOC:ha, PMID:27404358]", "GOBP_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY": "Any process that modulates the frequency, rate or extent of tight junction assembly. [GOC:BHF]", "GOBP_REGULATION_OF_BILE_ACID_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_BILE_ACID_METABOLIC_PROCESS": "", "GOBP_REGULATION_OF_BEHAVIOR": "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. [GOC:go_curators, GOC:pr]", "GOBP_REGULATION_OF_BILE_ACID_SECRETION": "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]", "GOBP_REGULATION_OF_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA": "Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida. [GOC:obol]", "GOBP_REGULATION_OF_BINDING": "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. [GOC:ai]", "GOBP_REGULATION_OF_BLOOD_BRAIN_BARRIER_PERMEABILITY": "Any process that modulates blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653]", "GOBP_REGULATION_OF_BIOLOGICAL_PROCESS_INVOLVED_IN_SYMBIOTIC_INTERACTION": "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. [GOC:jl]", "GOBP_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. [GOC:mah]", "GOBP_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN": "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]", "GOBP_REGULATION_OF_BLOOD_VESSEL_REMODELING": "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_BLOOD_CIRCULATION": "Any process that modulates the frequency, rate or extent of blood circulation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]", "GOBP_REGULATION_OF_BLOOD_PRESSURE": "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]", "GOBP_REGULATION_OF_BONE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of bone development. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]", "GOBP_REGULATION_OF_BMP_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. [GOC:mah]", "GOBP_REGULATION_OF_BONE_MINERALIZATION": "Any process that modulates the frequency, rate or extent of bone mineralization. [GOC:go_curators]", "GOBP_REGULATION_OF_BONE_MINERALIZATION_INVOLVED_IN_BONE_MATURATION": "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_BONE_REMODELING": "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. [GOC:ai]", "GOBP_REGULATION_OF_BODY_FLUID_LEVELS": "Any process that modulates the levels of body fluids. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS": "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. [GOC:dph, GOC:yaf]", "GOBP_REGULATION_OF_BONE_RESORPTION": "", "GOBP_REGULATION_OF_BRANCHING_INVOLVED_IN_PROSTATE_GLAND_MORPHOGENESIS": "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. [GOC:dph]", "GOBP_REGULATION_OF_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS": "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. [GOC:dph, GOC:tb, GOC:yaf]", "GOBP_REGULATION_OF_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS": "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium. [GOC:dph]", "GOBP_REGULATION_OF_BRANCHING_MORPHOGENESIS_OF_A_NERVE": "", "GOBP_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION": "Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [GOC:tb]", "GOBP_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS": "Any process that modulates the frequency, rate, or extent of B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. [GOC:ai]", "GOBP_REGULATION_OF_B_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of B cell activation. [GOC:ai]", "GOBP_REGULATION_OF_B_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of B cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_B_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of B cell proliferation. [GOC:mah]", "GOBP_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY": "Any process that modulates the frequency, rate, or extent of B cell mediated immunity. [GOC:add]", "GOBP_REGULATION_OF_CALCIDIOL_1_MONOOXYGENASE_ACTIVITY": "", "GOBP_REGULATION_OF_CALCIUM_IMPORT_INTO_THE_MITOCHONDRION": "Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion. [GOC:sl, PMID:24085037]", "GOBP_REGULATION_OF_CALCINEURIN_MEDIATED_SIGNALING": "Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling. [PMID:25081204]", "GOBP_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS": "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. [GOC:go_curators]", "GOBP_REGULATION_OF_CALCIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE": "Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515]", "GOBP_REGULATION_OF_CALCIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]", "GOBP_REGULATION_OF_CALCIUM_ION_IMPORT": "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]", "GOBP_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL": "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOBP_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "", "GOBP_REGULATION_OF_CAMP_MEDIATED_SIGNALING": "", "GOBP_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING": "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. [GOC:ai]", "GOBP_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT": "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]", "GOBP_REGULATION_OF_CALCIUM_ION_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. [GOC:mlg]", "GOBP_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. [GOC:jl]", "GOBP_REGULATION_OF_CARDIAC_CONDUCTION": "Any process that modulates the frequency, rate or extent of cardiac conduction. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_ADAPTATION": "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION": "Any process that modulates the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:rph, PMID:20951801]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL_INVOLVED_IN_REGULATION_OF_CONTRACTION": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. [GOC:go_curators]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:dos, GOC:mtg_cardiac_conduct_nov11]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_POTENTIAL": "Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION": "Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. [GOC:BHF, GOC:dos, GOC:rl]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION": "Any process that modulates the frequency, rate or extent of cardiac muscle contraction. [GOC:ecd]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING": "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. [GOC:vk]", "GOBP_REGULATION_OF_CARDIOBLAST_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. [GOC:ai]", "GOBP_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION": "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CARDIOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of cardiocyte differentiation. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]", "GOBP_REGULATION_OF_CARTILAGE_DEVELOPMENT": "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]", "GOBP_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. [GOC:go_curators]", "GOBP_REGULATION_OF_CATECHOLAMINE_UPTAKE_INVOLVED_IN_SYNAPTIC_TRANSMISSION": "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. [GOC:ai]", "GOBP_REGULATION_OF_CATION_CHANNEL_ACTIVITY": "", "GOBP_REGULATION_OF_CAVEOLIN_MEDIATED_ENDOCYTOSIS": "Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis. [GOC:obol]", "GOBP_REGULATION_OF_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. [GOC:go_curators]", "GOBP_REGULATION_OF_CD40_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway. [GOC:mah]", "GOBP_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. [GOC:obol]", "GOBP_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. [GOC:add, GOC:pr, ISBN:0781735149]", "GOBP_REGULATION_OF_CD4_POSITIVE_CD25_POSITIVE_ALPHA_BETA_REGULATORY_T_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. [GOC:mah]", "GOBP_REGULATION_OF_CATALYTIC_ACTIVITY": "Any process that modulates the activity of an enzyme. [GOC:ai, GOC:ebc, GOC:vw]", "GOBP_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]", "GOBP_REGULATION_OF_CD8_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation. [GOC:add, ISBN:0781735149]", "GOBP_REGULATION_OF_CDC42_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction. [GOC:mah]", "GOBP_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS": "", "GOBP_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS": "", "GOBP_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS": "", "GOBP_REGULATION_OF_CELLULAR_PH_REDUCTION": "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell. [GOC:mah]", "GOBP_REGULATION_OF_CELLULAR_EXTRAVASATION": "Any process that modulates the frequency, rate, or extent of cellular extravasation. [GOC:add]", "GOBP_REGULATION_OF_CELLULAR_COMPONENT_SIZE": "A process that modulates the size of a cellular component. [GOC:mah]", "GOBP_REGULATION_OF_CELLULAR_RESPIRATION": "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. [GOC:jl]", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT": "Any process that modulates the frequency, rate or extent of cellular response to heat. [GOC:TermGenie, GOC:yaf]", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA": "Any process that modulates the frequency, rate or extent of cellular response to hypoxia. [GOC:TermGenie, GOC:yaf]", "GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS": "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. [GOC:jl]", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS": "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:tb]", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_MACROPHAGE_COLONY_STIMULATING_FACTOR_STIMULUS": "", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS": "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. [GOC:TermGenie, GOC:yaf]", "GOBP_REGULATION_OF_CELLULAR_LOCALIZATION": "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS": "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress. [GOC:mah, GOC:TermGenie]", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS": "", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS": "Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370]", "GOBP_REGULATION_OF_CELLULAR_SENESCENCE": "Any process that modulates the frequency, rate or extent of cellular senescence. [GOC:BHF]", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS": "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]", "GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS": "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:dhl]", "GOBP_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN": "Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. [GOC:obol]", "GOBP_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_INTEGRIN": "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin. [GOC:add]", "GOBP_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN": "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]", "GOBP_REGULATION_OF_CELL_CHEMOTAXIS_TO_FIBROBLAST_GROWTH_FACTOR": "Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752]", "GOBP_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING": "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. [GOC:dph, GOC:kmv, GOC:tb]", "GOBP_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING_INVOLVED_IN_CARDIAC_CONDUCTION": "Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]", "GOBP_REGULATION_OF_CELL_ADHESION": "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. [GOC:mah]", "GOBP_REGULATION_OF_CELL_CELL_ADHESION": "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. [GOC:isa_complete]", "GOBP_REGULATION_OF_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:ai]", "GOBP_REGULATION_OF_CELL_CYCLE_CHECKPOINT": "Any process that modulates the frequency, rate or extent of cell cycle checkpoint. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]", "GOBP_REGULATION_OF_CELL_CYCLE": "Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION": "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION": "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle. [GO_REF:0000058, GOC:jl, GOC:TermGenie]", "GOBP_REGULATION_OF_CELL_DIVISION": "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. [GOC:go_curators]", "GOBP_REGULATION_OF_CELL_FATE_COMMITMENT": "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION": "Any process that modulates the frequency, rate or extent of cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "GOBP_REGULATION_OF_CELL_CYCLE_PROCESS": "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CELL_FATE_SPECIFICATION": "Any process that mediates the adoption of a specific fate by a cell. [GOC:go_curators]", "GOBP_REGULATION_OF_CELL_DEVELOPMENT": "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CELL_GROWTH_INVOLVED_IN_CARDIAC_MUSCLE_CELL_DEVELOPMENT": "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. [GOC:dph]", "GOBP_REGULATION_OF_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. [GOC:go_curators]", "GOBP_REGULATION_OF_CELL_GROWTH": "Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]", "GOBP_REGULATION_OF_CELL_JUNCTION_ASSEMBLY": "Any process that modulates the frequency, rate or extent of cell junction assembly. [GOC:TermGenie]", "GOBP_REGULATION_OF_CELL_MATURATION": "Any process that modulates the frequency, rate or extent of cell maturation. [GO_REF:0000058, GOC:TermGenie, PMID:17459944]", "GOBP_REGULATION_OF_CELL_KILLING": "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. [GOC:mah]", "GOBP_REGULATION_OF_CELL_MATRIX_ADHESION": "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. [GOC:hjd]", "GOBP_REGULATION_OF_CELL_PROJECTION_ASSEMBLY": "Any process that modulates the rate, frequency, or extent of cell projection assembly. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CELL_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. [GOC:isa_complete]", "GOBP_REGULATION_OF_CELL_PROJECTION_SIZE": "A process that modulates the size of a cell projection. [GOC:mah]", "GOBP_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. [GOC:TermGenie, PMID:18182616]", "GOBP_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS": "Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]", "GOBP_REGULATION_OF_CELL_PROLIFERATION_IN_BONE_MARROW": "A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow. [GOC:mah, GOC:yaf, PMID:17063141]", "GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. [GOC:mah]", "GOBP_REGULATION_OF_CELL_SHAPE": "Any process that modulates the surface configuration of a cell. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_REGULATION_OF_CELL_SIZE": "Any process that modulates the size of a cell. [GOC:go_curators]", "GOBP_REGULATION_OF_CENTRIOLE_REPLICATION": "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. [GOC:ai]", "GOBP_REGULATION_OF_CELL_SUBSTRATE_JUNCTION_ORGANIZATION": "Any process that modulates the frequency, rate or extent of cell-substrate junction organization. [GOC:aruk]", "GOBP_REGULATION_OF_CENTROMERE_COMPLEX_ASSEMBLY": "", "GOBP_REGULATION_OF_CENTROMERIC_SISTER_CHROMATID_COHESION": "Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome. [GOC:mah]", "GOBP_REGULATION_OF_CELL_SUBSTRATE_ADHESION": "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. [GOC:dph, GOC:pf, GOC:tb]", "GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION": "Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]", "GOBP_REGULATION_OF_CENTROSOME_CYCLE": "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. [GOC:ai]", "GOBP_REGULATION_OF_CEREBELLAR_GRANULE_CELL_PRECURSOR_PROLIFERATION": "The process that modulates the frequency, rate or extent of granule cell precursor proliferation. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]", "GOBP_REGULATION_OF_CGMP_MEDIATED_SIGNALING": "", "GOBP_REGULATION_OF_CHAPERONE_MEDIATED_AUTOPHAGY": "Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]", "GOBP_REGULATION_OF_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency or extent of a chemokine-mediated signaling pathway. [GOC:mah]", "GOBP_REGULATION_OF_CHLORIDE_TRANSPORT": "", "GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX": "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CHEMOTAXIS": "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]", "GOBP_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. [GOC:go_curators]", "GOBP_REGULATION_OF_CHOLESTEROL_STORAGE": "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CHONDROCYTE_DEVELOPMENT": "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. [GOC:BHF, GOC:dph]", "GOBP_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS": "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CHROMATIN_BINDING": "", "GOBP_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]", "GOBP_REGULATION_OF_CHROMOSOME_CONDENSATION": "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_CHROMATIN_ORGANIZATION": "Any process that modulates the frequency, rate or extent of chromatin organization. [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879]", "GOBP_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE": "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. [GOC:add]", "GOBP_REGULATION_OF_CILIUM_BEAT_FREQUENCY": "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium. [GOC:dph]", "GOBP_REGULATION_OF_CHROMOSOME_SEGREGATION": "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. [GOC:ai]", "GOBP_REGULATION_OF_CILIUM_ASSEMBLY": "Any process that modulates the frequency, rate or extent of cilium assembly. [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]", "GOBP_REGULATION_OF_CHROMOSOME_ORGANIZATION": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. [GOC:mah]", "GOBP_REGULATION_OF_CILIUM_BEAT_FREQUENCY_INVOLVED_IN_CILIARY_MOTILITY": "Any process that modulates the frequency of cilium beating involved in ciliary motility. [GOC:BHF, GOC:cilia, GOC:dph, GOC:krc, GOC:tb]", "GOBP_REGULATION_OF_CILIUM_DEPENDENT_CELL_MOTILITY": "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. [GOC:cilia, GOC:jl, GOC:TermGenie]", "GOBP_REGULATION_OF_CILIUM_MOVEMENT": "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. [GOC:dph]", "GOBP_REGULATION_OF_CIRCADIAN_RHYTHM": "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb]", "GOBP_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP": "", "GOBP_REGULATION_OF_CIRCULATING_FIBRINOGEN_LEVELS": "Any process that modulates the quantity of fibrinogen circulating in the bloodstream. [GOC:jl]", "GOBP_REGULATION_OF_CLATHRIN_DEPENDENT_ENDOCYTOSIS": "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. [GOC:mah]", "GOBP_REGULATION_OF_COLLAGEN_FIBRIL_ORGANIZATION": "Any process that modulates the frequency, rate or extent of collagen fibril organization. [GO_REF:0000058, GOC:TermGenie, PMID:25451920]", "GOBP_REGULATION_OF_COAGULATION": "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. [GOC:ai]", "GOBP_REGULATION_OF_COLLATERAL_SPROUTING": "Any process that modulates the frequency, rate or extent of collateral sprouting. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]", "GOBP_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY": "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation. [GOC:go_curators]", "GOBP_REGULATION_OF_COA_TRANSFERASE_ACTIVITY": "", "GOBP_REGULATION_OF_COMPLEMENT_ACTIVATION": "Any process that modulates the frequency, rate or extent of complement activation. [GOC:go_curators]", "GOBP_REGULATION_OF_COMPLEMENT_DEPENDENT_CYTOTOXICITY": "Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity. [GO_REF:0000058, GOC:TermGenie, PMID:24280217]", "GOBP_REGULATION_OF_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY": "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation. [GOC:go_curators]", "GOBP_REGULATION_OF_CONNECTIVE_TISSUE_REPLACEMENT": "Any process that modulates the frequency, rate or extent of connective tissue replacement. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]", "GOBP_REGULATION_OF_COPII_VESICLE_COATING": "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]", "GOBP_REGULATION_OF_CORE_PROMOTER_BINDING": "", "GOBP_REGULATION_OF_CORTICOTROPIN_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell. [GOC:ai, GOC:dph]", "GOBP_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION": "", "GOBP_REGULATION_OF_CORTISOL_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of cortisol biosynthetic process. [GOC:obol, GOC:yaf]", "GOBP_REGULATION_OF_CYCLASE_ACTIVITY": "", "GOBP_REGULATION_OF_CRISTAE_FORMATION": "", "GOBP_REGULATION_OF_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY": "", "GOBP_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "", "GOBP_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY": "", "GOBP_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS": "", "GOBP_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY": "", "GOBP_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS": "", "GOBP_REGULATION_OF_CYTOKINETIC_PROCESS": "Any process that modulates the frequency, rate or extent of a cytokinetic process. [GOC:mah]", "GOBP_REGULATION_OF_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY": "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. [GOC:dph, GOC:krc, GOC:tb]", "GOBP_REGULATION_OF_CYTOKINESIS": "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. [GOC:mah]", "GOBP_REGULATION_OF_CYTOPLASMIC_TRANSLATIONAL_INITIATION": "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation. [GO_REF:0000058, GOC:TermGenie, PMID:12242291]", "GOBP_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway. [GOC:bf, GOC:jl]", "GOBP_REGULATION_OF_CYTOPLASMIC_TRANSLATION": "Any process that modulates the frequency, rate or extent of cytoplasmic translation. [GOC:obol]", "GOBP_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM": "Any process that modulates the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749]", "GOBP_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION": "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. [GOC:ai, GOC:mah, GOC:rph]", "GOBP_REGULATION_OF_DEFENSE_RESPONSE_TO_FUNGUS": "Any process that modulates the frequency, rate or extent of defense response to fungus. [GOC:dhl, GOC:TermGenie, PMID:22242006]", "GOBP_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS": "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. [GOC:ai]", "GOBP_REGULATION_OF_CYTOSKELETON_ORGANIZATION": "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:ai]", "GOBP_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST": "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. [GOC:ai, GOC:dph]", "GOBP_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY": "Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204]", "GOBP_REGULATION_OF_DENDRITE_EXTENSION": "Any process that modulates the frequency, rate or extent of dendrite extension. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]", "GOBP_REGULATION_OF_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION": "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]", "GOBP_REGULATION_OF_DENDRITE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of dendrite development. [GOC:ai]", "GOBP_REGULATION_OF_DEFENSE_RESPONSE": "Any process that modulates the frequency, rate or extent of a defense response. [GOC:mah]", "GOBP_REGULATION_OF_DENDRITIC_CELL_CHEMOTAXIS": "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis. [GOC:obol]", "GOBP_REGULATION_OF_DENDRITE_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]", "GOBP_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of dendritic cell differentiation. [GOC:obol]", "GOBP_REGULATION_OF_DENDRITIC_SPINE_MAINTENANCE": "Any process that modulates the frequency, rate or extent of dendritic spine maintenance. [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732]", "GOBP_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT": "Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. [GOC:dph]", "GOBP_REGULATION_OF_DEOXYRIBONUCLEASE_ACTIVITY": "", "GOBP_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS": "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]", "GOBP_REGULATION_OF_DEPHOSPHORYLATION": "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. [GOC:bf]", "GOBP_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC": "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. [PMID:9442909]", "GOBP_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS": "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:jl]", "GOBP_REGULATION_OF_DNA_BINDING": "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:ai, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_DEVELOPMENTAL_GROWTH": "Any process that modulates the frequency, rate or extent of developmental growth. [GOC:go_curators]", "GOBP_REGULATION_OF_DNA_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of DNA catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:2001740]", "GOBP_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY": "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]", "GOBP_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of DNA biosynthetic process. [GOC:obol]", "GOBP_REGULATION_OF_DNA_DAMAGE_CHECKPOINT": "Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. [GOC:obol]", "GOBP_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR": "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl]", "GOBP_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR_RESULTING_IN_TRANSCRIPTION_OF_P21_CLASS_MEDIATOR": "", "GOBP_REGULATION_OF_DNA_DEMETHYLATION": "", "GOBP_REGULATION_OF_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY": "", "GOBP_REGULATION_OF_DNA_LIGATION": "", "GOBP_REGULATION_OF_DNA_METHYLATION_DEPENDENT_HETEROCHROMATIN_FORMATION": "", "GOBP_REGULATION_OF_DNA_RECOMBINATION": "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. [GOC:go_curators, ISBN:0198506732]", "GOBP_REGULATION_OF_DNA_STRAND_ELONGATION": "Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. [GOC:mah]", "GOBP_REGULATION_OF_DNA_TEMPLATED_DNA_REPLICATION_INITIATION": "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. [GOC:mah]", "GOBP_REGULATION_OF_DNA_REPAIR": "Any process that modulates the frequency, rate or extent of DNA repair. [GOC:go_curators]", "GOBP_REGULATION_OF_DNA_REPLICATION": "Any process that modulates the frequency, rate or extent of DNA replication. [GOC:go_curators]", "GOBP_REGULATION_OF_DNA_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. [GOC:ai]", "GOBP_REGULATION_OF_DNA_TEMPLATED_DNA_REPLICATION": "Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION": "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]", "GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION": "Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. [GOC:mah, GOC:txnOH]", "GOBP_REGULATION_OF_DNA_TOPOISOMERASE_ATP_HYDROLYZING_ACTIVITY": "", "GOBP_REGULATION_OF_DOPAMINERGIC_NEURON_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:15522889]", "GOBP_REGULATION_OF_DOPAMINE_SECRETION": "", "GOBP_REGULATION_OF_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. [GOC:dph]", "GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION": "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. [GOC:dph, GOC:jp, GOC:tb]", "GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_NONHOMOLOGOUS_END_JOINING": "Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining. [GOC:obol]", "GOBP_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT": "Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. [GOC:BHF]", "GOBP_REGULATION_OF_EATING_BEHAVIOR": "Any process that modulates the frequency, rate or extent of eating behavior. [GO_REF:0000058, GOC:TermGenie, PMID:11961051]", "GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR": "Any process that modulates the frequency, rate or extent of double-strand break repair. [GOC:BHF]", "GOBP_REGULATION_OF_ELECTRON_TRANSFER_ACTIVITY": "", "GOBP_REGULATION_OF_ENAMEL_MINERALIZATION": "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_EMBRYONIC_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of embryonic development. [GOC:go_curators]", "GOBP_REGULATION_OF_ENDOCYTIC_RECYCLING": "Any process that modulates the frequency, rate or extent of endocytic recycling. [GOC:obol]", "GOBP_REGULATION_OF_ENDOCRINE_PROCESS": "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. [GOC:jl]", "GOBP_REGULATION_OF_ENDODEOXYRIBONUCLEASE_ACTIVITY": "", "GOBP_REGULATION_OF_ENDODERMAL_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of endodermal cell differentiation. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]", "GOBP_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352]", "GOBP_REGULATION_OF_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK_ORGANIZATION": "Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604]", "GOBP_REGULATION_OF_ENDOSOME_ORGANIZATION": "Any process that modulates the frequency, rate or extent of endosome organization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594]", "GOBP_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE": "Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. [GOC:TermGenie]", "GOBP_REGULATION_OF_ENDOSOME_SIZE": "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. [GOC:ai]", "GOBP_REGULATION_OF_ENDOCYTOSIS": "Any process that modulates the frequency, rate or extent of endocytosis. [GOC:go_curators]", "GOBP_REGULATION_OF_ENDOSOME_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT": "Any process that modulates the frequency, rate or extent of endosome to plasma membrane protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:22869721]", "GOBP_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS": "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. [GOC:BHF]", "GOBP_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of endothelial cell development. [GOC:pr, GOC:TermGenie, PMID:19470579]", "GOBP_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of endothelial cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_ENDOTHELIAL_TUBE_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. [GOC:dph, GOC:TermGenie]", "GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION": "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_ENTRY_OF_BACTERIUM_INTO_HOST_CELL": "Any process that modulates the frequency, rate or extent of entry of bacterium into host cell. [GOC:obol]", "GOBP_REGULATION_OF_EOSINOPHIL_MIGRATION": "Any process that modulates the frequency, rate or extent of eosinophil migration. [GOC:mah]", "GOBP_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY": "", "GOBP_REGULATION_OF_EPIDERMIS_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of epidermis development. [GOC:go_curators]", "GOBP_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS": "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19137015]", "GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of epithelial cell differentiation. [GOC:mah]", "GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. [GOC:mtg_kidney_jan10, GOC:yaf]", "GOBP_REGULATION_OF_EPITHELIAL_CELL_MIGRATION": "Any process that modulates the frequency, rate or extent of epithelial cell migration. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION": "Any process that modulates the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]", "GOBP_REGULATION_OF_ERAD_PATHWAY": "Any process that modulates the frequency, rate or extent of ERAD pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]", "GOBP_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION_INVOLVED_IN_LUNG_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. [PMID:21513708]", "GOBP_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of epithelial cell proliferation. [GOC:ai]", "GOBP_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION": "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT": "Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_ERBB_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of ERBB signaling pathway. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY": "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME": "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_ESTABLISHMENT_OF_T_CELL_POLARITY": "Any process that modulates the frequency, rate or extent of establishment of T cell polarity. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]", "GOBP_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY": "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. [GOC:mah]", "GOBP_REGULATION_OF_EXCITATORY_SYNAPSE_ASSEMBLY": "Any process that modulates the frequency, rate or extent of excitatory synapse assembly. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]", "GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION": "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:16857185]", "GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION": "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_EXCRETION": "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. [GOC:jl]", "GOBP_REGULATION_OF_EXIT_FROM_MITOSIS": "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. [GOC:rn]", "GOBP_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS": "Any process that modulates the frequency, rate or extent of execution phase of apoptosis. [GOC:mtg_apoptosis, GOC:TermGenie]", "GOBP_REGULATION_OF_EXOSOMAL_SECRETION": "Any process that modulates the frequency, rate or extent of exosomal secretion. [GO_REF:0000058, GOC:TermGenie, PMID:24105262]", "GOBP_REGULATION_OF_EXOCYTOSIS": "Any process that modulates the frequency, rate or extent of exocytosis. [GOC:go_curators]", "GOBP_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY": "Any process that modulates the frequency, rate or extent of extracellular matrix assembly. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_EXTENT_OF_CELL_GROWTH": "Any process that modulates the extent of cell growth. [GOC:mah, GOC:vw]", "GOBP_REGULATION_OF_EXTRACELLULAR_MATRIX_CONSTITUENT_SECRETION": "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY": "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION": "Any process that modulates the frequency, rate or extent of extracellular matrix organization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]", "GOBP_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND": "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS": "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. [GOC:TermGenie, PMID:17245429]", "GOBP_REGULATION_OF_FAS_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of Fas signaling pathway. [GOC:TermGenie, PMID:17245429]", "GOBP_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_FATTY_ACID_BETA_OXIDATION": "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. [GOC:mah]", "GOBP_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. [GOC:go_curators, GOC:jl]", "GOBP_REGULATION_OF_FATTY_ACID_OXIDATION": "Any process that modulates the frequency, rate or extent of fatty acid oxidation. [GOC:ai]", "GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]", "GOBP_REGULATION_OF_FATTY_ACID_TRANSPORT": "Any process that modulates the frequency, rate or extent of fatty acid transport. [GOC:BHF]", "GOBP_REGULATION_OF_FAT_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of fat cell proliferation. [GOC:mah, GOC:sl]", "GOBP_REGULATION_OF_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway.. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_FEAR_RESPONSE": "Any process that modulates the frequency, rate or extent of fear response. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262]", "GOBP_REGULATION_OF_FAT_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_FEEDING_BEHAVIOR": "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of female gonad development. [GOC:obol]", "GOBP_REGULATION_OF_FEMALE_RECEPTIVITY": "", "GOBP_REGULATION_OF_FEVER_GENERATION": "Any process that modulates the rate or extent of fever generation. [GOC:add, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_FIBRINOLYSIS": "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. [GOC:ai]", "GOBP_REGULATION_OF_FERTILIZATION": "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). [GOC:DHL, PMID:20478994]", "GOBP_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS": "", "GOBP_REGULATION_OF_FIBROBLAST_PROLIFERATION": "", "GOBP_REGULATION_OF_FIBROBLAST_MIGRATION": "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. [GOC:go_curators]", "GOBP_REGULATION_OF_FOCAL_ADHESION_DISASSEMBLY": "Any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components. [PMID:25490267]", "GOBP_REGULATION_OF_FLAGELLATED_SPERM_MOTILITY": "Any process that modulates the frequency, rate or extent of flagellated sperm motility. [GOC:cilia, GOC:krc, GOC:TermGenie]", "GOBP_REGULATION_OF_FILOPODIUM_ASSEMBLY": "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_G2_MI_TRANSITION_OF_MEIOTIC_CELL_CYCLE": "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. [GOC:vw]", "GOBP_REGULATION_OF_GAMMA_AMINOBUTYRIC_ACID_SECRETION": "", "GOBP_REGULATION_OF_FOREBRAIN_NEURON_DIFFERENTIATION": "", "GOBP_REGULATION_OF_GAMMA_DELTA_T_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation. [GOC:ai]", "GOBP_REGULATION_OF_GAMMA_DELTA_T_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_GAP_JUNCTION_ASSEMBLY": "Any process that modulates the frequency, rate or extent of gap junction assembly. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399]", "GOBP_REGULATION_OF_GASTRIC_ACID_SECRETION": "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_GASTRULATION": "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_GENE_SILENCING_BY_REGULATORY_NCRNA": "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. [GOC:jl]", "GOBP_REGULATION_OF_GERM_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of germ cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]", "GOBP_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of glia cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_GERMINAL_CENTER_FORMATION": "Any process that modulates the frequency, rate, or extent of germinal center formation. [GOC:add]", "GOBP_REGULATION_OF_GLIAL_CELL_APOPTOTIC_PROCESS": "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. [GOC:mah, GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_GLIAL_CELL_MIGRATION": "Any process that modulates the frequency, rate or extent of glial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]", "GOBP_REGULATION_OF_GLIOGENESIS": "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. [GOC:ef]", "GOBP_REGULATION_OF_GLIAL_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of glial cell proliferation. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_GLOMERULAR_FILTRATION": "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. [GOC:mtg_cardio]", "GOBP_REGULATION_OF_GLUCAGON_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of glucagon. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_GLOMERULUS_DEVELOPMENT": "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. [GOC:dph, GOC:tb, GOC:yaf]", "GOBP_REGULATION_OF_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS": "", "GOBP_REGULATION_OF_GLUCOCORTICOID_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. [GOC:mah]", "GOBP_REGULATION_OF_GLUCOCORTICOID_RECEPTOR_SIGNALING_PATHWAY": "", "GOBP_REGULATION_OF_GLUCOCORTICOID_SECRETION": "", "GOBP_REGULATION_OF_GLUCOKINASE_ACTIVITY": "", "GOBP_REGULATION_OF_GLUCOSE_IMPORT": "", "GOBP_REGULATION_OF_GLUCONEOGENESIS": "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. [GOC:go_curators]", "GOBP_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS": "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. [GOC:BHF, GOC:tb]", "GOBP_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT": "", "GOBP_REGULATION_OF_GLUCOSYLCERAMIDE_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process. [GOC:BHF]", "GOBP_REGULATION_OF_GLUTAMATE_RECEPTOR_CLUSTERING": "Any process that modulates the frequency, rate or extent of glutamate receptor clustering. [GOC:ha, PMID:28455372]", "GOBP_REGULATION_OF_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_GLUTAMATE_SECRETION_NEUROTRANSMISSION": "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission. [GO_REF:0000058, GOC:TermGenie, PMID:16782817]", "GOBP_REGULATION_OF_GLUTAMATE_SECRETION": "Any process that modulates the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]", "GOBP_REGULATION_OF_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS": "", "GOBP_REGULATION_OF_GLYCOGEN_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. [GOC:go_curators]", "GOBP_REGULATION_OF_GLYCOGEN_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. [GOC:go_curators]", "GOBP_REGULATION_OF_GLYCOGEN_STARCH_SYNTHASE_ACTIVITY": "", "GOBP_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. [GOC:mah]", "GOBP_REGULATION_OF_GOLGI_ORGANIZATION": "Any process that modulates the frequency, rate or extent of Golgi organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]", "GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]", "GOBP_REGULATION_OF_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT": "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. [GOC:jl]", "GOBP_REGULATION_OF_GONAD_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of gonad development. [GO_REF:0000058, GOC:TermGenie, PMID:15342467]", "GOBP_REGULATION_OF_GONADOTROPIN_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. [GOC:mah]", "GOBP_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS": "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. [GOC:mah]", "GOBP_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of granulocyte differentiation. [GOC:mah]", "GOBP_REGULATION_OF_GROWTH_HORMONE_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. [GOC:BHF, GOC:dph]", "GOBP_REGULATION_OF_GTP_BINDING": "", "GOBP_REGULATION_OF_GTPASE_ACTIVITY": "Any process that modulates the rate of GTP hydrolysis by a GTPase. [GOC:jl, GOC:mah]", "GOBP_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY": "", "GOBP_REGULATION_OF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY": "", "GOBP_REGULATION_OF_GROWTH_RATE": "Any process that modulates the rate of growth of all or part of an organism. [GOC:mah]", "GOBP_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of hair follicle development. [GOC:ai]", "GOBP_REGULATION_OF_HAIR_CYCLE": "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. [GOC:go_curators, PMID:12230507]", "GOBP_REGULATION_OF_GROWTH": "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. [GOC:ems, GOC:mah]", "GOBP_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. [GOC:go_curators]", "GOBP_REGULATION_OF_HEART_CONTRACTION": "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_REGULATION_OF_HEART_GROWTH": "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_HEART_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of heart morphogenesis. [GOC:BHF]", "GOBP_REGULATION_OF_HEART_RATE": "Any process that modulates the frequency or rate of heart contraction. [GOC:dph, GOC:tb, PMID:10358008]", "GOBP_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION": "A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_REGULATION_OF_HEART_RATE_BY_CHEMICAL_SIGNAL": "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine. [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb]", "GOBP_REGULATION_OF_HELICASE_ACTIVITY": "", "GOBP_REGULATION_OF_HEAT_GENERATION": "Any process that modulates the rate or extent of heat generation. [GOC:dph, GOC:mah, GOC:tb]", "GOBP_REGULATION_OF_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. [GOC:TermGenie, PMID:23403623]", "GOBP_REGULATION_OF_HEMATOPOIETIC_STEM_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. [GOC:TermGenie, PMID:23403623]", "GOBP_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. [GOC:BHF, GOC:rl, GOC:TermGenie]", "GOBP_REGULATION_OF_HEMOGLOBIN_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:ai]", "GOBP_REGULATION_OF_HEPATIC_STELLATE_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation. [GOC:obol]", "GOBP_REGULATION_OF_HEPATOCYTE_PROLIFERATION": "Any process that modulates the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_HEPATOCYTE_APOPTOTIC_PROCESS": "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:8649852]", "GOBP_REGULATION_OF_HETEROCHROMATIN_FORMATION": "", "GOBP_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION": "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. [GOC:add]", "GOBP_REGULATION_OF_HEXOKINASE_ACTIVITY": "", "GOBP_REGULATION_OF_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE": "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_HEMOPOIESIS": "Any process that modulates the frequency, rate or extent of hemopoiesis. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]", "GOBP_REGULATION_OF_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY": "", "GOBP_REGULATION_OF_HIPPOCAMPAL_NEURON_APOPTOTIC_PROCESS": "", "GOBP_REGULATION_OF_HISTAMINE_SECRETION_BY_MAST_CELL": "Any process that modulates the frequency, rate or extent of histamine secretion by mast cell. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931]", "GOBP_REGULATION_OF_HIPPO_SIGNALING": "Any process that modulates the frequency, rate or extent of hippo signaling. [GOC:bf]", "GOBP_REGULATION_OF_HOMOPHILIC_CELL_ADHESION": "Any process that modulates the frequency, rate or extent of homophilic cell adhesion. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833]", "GOBP_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. [GOC:ai]", "GOBP_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION": "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. [GOC:add]", "GOBP_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN": "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. [GOC:add]", "GOBP_REGULATION_OF_HORMONE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. [GOC:mah]", "GOBP_REGULATION_OF_HYALURONAN_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. [GOC:TermGenie, GOC:yaf]", "GOBP_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate, or extent of a humoral immune response. [GOC:add]", "GOBP_REGULATION_OF_HYDROGEN_PEROXIDE_BIOSYNTHETIC_PROCESS": "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. [GOC:dph, GOC:hjd, GOC:tb]", "GOBP_REGULATION_OF_HORMONE_LEVELS": "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. [PMID:14765119]", "GOBP_REGULATION_OF_HYDROGEN_PEROXIDE_MEDIATED_PROGRAMMED_CELL_DEATH": "Any process that modulates the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_HORMONE_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai]", "GOBP_REGULATION_OF_HYDROLASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. [GOC:ai]", "GOBP_REGULATION_OF_HYPERSENSITIVITY": "Any process that modulates the frequency, rate, or extent of hypersensitivity. [GOC:add]", "GOBP_REGULATION_OF_ICOSANOID_SECRETION": "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. [GOC:mah]", "GOBP_REGULATION_OF_INCLUSION_BODY_ASSEMBLY": "Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS": "Any process that modulates the frequency, rate, or extent of an immune effector process. [GOC:add]", "GOBP_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION": "Any process that modulates the frequency, rate, or extent of immunoglobulin production. [GOC:add]", "GOBP_REGULATION_OF_INFLAMMASOME_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of an inflammasome-mediated signaling pathway. [PMID:33467177]", "GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_WOUNDING": "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821]", "GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS": "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add]", "GOBP_REGULATION_OF_INNER_EAR_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE": "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai]", "GOBP_REGULATION_OF_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]", "GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS": "Any process that modulates the frequency, rate, or extent of an immune system process. [GOC:add]", "GOBP_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS": "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_INOSITOL_1_4_5_TRISPHOSPHATE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY": "", "GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc]", "GOBP_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]", "GOBP_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of insulin receptor signaling. [GOC:bf]", "GOBP_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS": "", "GOBP_REGULATION_OF_INTEGRIN_BIOSYNTHETIC_PROCESS": "", "GOBP_REGULATION_OF_INTEGRIN_ACTIVATION": "Any process that modulates the frequency, rate, or extent of integrin activation. [GOC:add]", "GOBP_REGULATION_OF_INSULIN_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of insulin. [GOC:ai]", "GOBP_REGULATION_OF_INTEGRIN_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway. [GOC:obol]", "GOBP_REGULATION_OF_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway. [GOC:obol]", "GOBP_REGULATION_OF_INTESTINAL_ABSORPTION": "Any process that modulates the frequency, rate or extent of intestinal absorption. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120]", "GOBP_REGULATION_OF_INTERLEUKIN_6_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency or extent of an interleukin-6-mediated signaling pathway. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_INTESTINAL_LIPID_ABSORPTION": "", "GOBP_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. [GOC:mah]", "GOBP_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. [GOC:mah]", "GOBP_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. [GOC:mah]", "GOBP_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. [GOC:mah]", "GOBP_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION": "", "GOBP_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_HYDROGEN_PEROXIDE": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. [GO_REF:0000058, GOC:TermGenie, PMID:18681888]", "GOBP_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. [GOC:TermGenie, PMID:17719541]", "GOBP_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]", "GOBP_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]", "GOBP_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OSMOTIC_STRESS": "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]", "GOBP_REGULATION_OF_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY": "", "GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. [GOC:mah]", "GOBP_REGULATION_OF_IRON_ION_TRANSMEMBRANE_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE": "Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]", "GOBP_REGULATION_OF_IRON_ION_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_REGULATION_OF_ISOMERASE_ACTIVITY": "", "GOBP_REGULATION_OF_ISOTYPE_SWITCHING_TO_IGE_ISOTYPES": "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes. [GOC:jid]", "GOBP_REGULATION_OF_I_KAPPAB_PHOSPHORYLATION": "", "GOBP_REGULATION_OF_ISOTYPE_SWITCHING": "Any process that modulates the frequency, rate or extent of isotype switching. [GOC:ai]", "GOBP_REGULATION_OF_JUN_KINASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of JUN kinase activity. [GOC:jl]", "GOBP_REGULATION_OF_JNK_CASCADE": "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]", "GOBP_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of keratinocyte differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_KERATINOCYTE_MIGRATION": "Any process that modulates the frequency, rate or extent of keratinocyte migration. [GOC:ai]", "GOBP_REGULATION_OF_KERATINOCYTE_PROLIFERATION": "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_KETONE_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_KIDNEY_SIZE": "Any process that modulates the size of a kidney. [GOC:bf]", "GOBP_REGULATION_OF_KIDNEY_DEVELOPMENT": "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:tb, GOC:yaf]", "GOBP_REGULATION_OF_KILLING_OF_CELLS_OF_ANOTHER_ORGANISM": "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism. [GOC:ai]", "GOBP_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY": "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_LAMELLIPODIUM_MORPHOGENESIS": "Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis. [GOC:mah]", "GOBP_REGULATION_OF_KINASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:bf]", "GOBP_REGULATION_OF_LENS_FIBER_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of lens fiber cell differentiation. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637]", "GOBP_REGULATION_OF_LEUKOCYTE_ADHESION_TO_ARTERIAL_ENDOTHELIAL_CELL": "", "GOBP_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION": "Any process that modulates the frequency, rate or extent of lamellipodium organization. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028]", "GOBP_REGULATION_OF_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL": "Any process that modulates the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866]", "GOBP_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS": "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_LEUKOCYTE_DEGRANULATION": "Any process that modulates the frequency, rate, or extent of leukocyte degranulation. [GOC:add, ISBN:0781735149]", "GOBP_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS": "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]", "GOBP_REGULATION_OF_LIGASE_ACTIVITY": "", "GOBP_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY": "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. [GOC:add]", "GOBP_REGULATION_OF_LEUKOCYTE_TETHERING_OR_ROLLING": "Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860]", "GOBP_REGULATION_OF_LIPASE_ACTIVITY": "", "GOBP_REGULATION_OF_LEUKOCYTE_PROLIFERATION": "Any process that modulates the frequency, rate or extent of leukocyte proliferation. [GOC:add, GOC:mah]", "GOBP_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of leukocyte differentiation. [GOC:add, GOC:TermGenie]", "GOBP_REGULATION_OF_LEUKOCYTE_MIGRATION": "Any process that modulates the frequency, rate, or extent of leukocyte migration. [GOC:add]", "GOBP_REGULATION_OF_LIPID_KINASE_ACTIVITY": "", "GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]", "GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. [GOC:ai]", "GOBP_REGULATION_OF_LIPID_LOCALIZATION": "Any process that modulates the frequency, rate or extent of lipid localization. [GO_REF:0000058, GOC:TermGenie, PMID:17564681]", "GOBP_REGULATION_OF_LIPID_TRANSPORT": "", "GOBP_REGULATION_OF_LIPOPHAGY": "Any process that modulates the frequency, rate or extent of lipophagy. [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]", "GOBP_REGULATION_OF_LIPID_STORAGE": "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY": "", "GOBP_REGULATION_OF_LIPID_TRANSPORTER_ACTIVITY": "", "GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. [GOC:go_curators]", "GOBP_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. [GOC:ai]", "GOBP_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. [GOC:mah]", "GOBP_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE": "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_LOCOMOTION_INVOLVED_IN_LOCOMOTORY_BEHAVIOR": "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. [GOC:dph, GOC:kmv, GOC:tb]", "GOBP_REGULATION_OF_LONG_CHAIN_FATTY_ACID_IMPORT_INTO_CELL": "Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell. [PMID:28178239]", "GOBP_REGULATION_OF_LONG_CHAIN_FATTY_ACID_IMPORT_ACROSS_PLASMA_MEMBRANE": "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY": "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. [GOC:jid, PMID:11891290]", "GOBP_REGULATION_OF_LONG_TERM_SYNAPTIC_DEPRESSION": "Any process that modulates the frequency, rate or extent of long term synaptic depression. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION": "Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_LUNG_BLOOD_PRESSURE": "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:mtg_cardio]", "GOBP_REGULATION_OF_LUTEINIZING_HORMONE_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone. [GOC:mah]", "GOBP_REGULATION_OF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE": "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_LOCOMOTION": "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. [GOC:ems]", "GOBP_REGULATION_OF_LYMPHANGIOGENESIS": "Any process that modulates the frequency, rate or extent of lymphangiogenesis. [GOC:dph, GOC:TermGenie, PMID:20133819]", "GOBP_REGULATION_OF_LYASE_ACTIVITY": "", "GOBP_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS": "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. [GOC:TermGenie]", "GOBP_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS": "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_REGULATION_OF_LYMPHOCYTE_ACTIVATION": "Any process that modulates the frequency, rate or extent of lymphocyte activation. [GOC:ai]", "GOBP_REGULATION_OF_LYMPHOCYTE_MIGRATION": "Any process that modulates the frequency, rate or extent of lymphocyte migration. [GOC:mah]", "GOBP_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of lymphocyte differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY": "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. [GOC:add]", "GOBP_REGULATION_OF_LYSOSOME_SIZE": "Any process that modulates the size of a lysosome. [PMID:31314175]", "GOBP_REGULATION_OF_LYSOSOMAL_LUMEN_PH": "Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. [GOC:rph]", "GOBP_REGULATION_OF_LYSOSOME_ORGANIZATION": "Any process that modulates the frequency, rate or extent of lysosome organization. [GO_REF:0000058, GOC:TermGenie, PMID:25561470]", "GOBP_REGULATION_OF_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:27010503]", "GOBP_REGULATION_OF_L_GLUTAMATE_IMPORT_ACROSS_PLASMA_MEMBRANE": "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell. [GOC:TermGenie]", "GOBP_REGULATION_OF_MACROAUTOPHAGY": "Any process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc]", "GOBP_REGULATION_OF_MACROPHAGE_APOPTOTIC_PROCESS": "Any process that modulates the frequency, rate or extent of macrophage apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_MACROPHAGE_CHEMOTAXIS": "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MACROPHAGE_ACTIVATION": "Any process that modulates the frequency or rate of macrophage activation. [GOC:jl]", "GOBP_REGULATION_OF_MACROPHAGE_FUSION": "Any process that modulates the frequency, rate or extent of macrophage fusion. [GOC:mah]", "GOBP_REGULATION_OF_MACROPHAGE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of macrophage differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION": "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MACROPHAGE_PROLIFERATION": "Any process that modulates the frequency, rate or extent of macrophage proliferation. [GOC:BHF, GOC:BHF_miRNA, GOC:rph]", "GOBP_REGULATION_OF_MAINTENANCE_OF_SISTER_CHROMATID_COHESION": "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained. [GOC:mah, GOC:vw]", "GOBP_REGULATION_OF_MALE_GONAD_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of male gonad development. [GOC:obol, GOC:yaf]", "GOBP_REGULATION_OF_MACROPHAGE_MIGRATION": "Any process that modulates the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]", "GOBP_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. [GOC:mah]", "GOBP_REGULATION_OF_MAST_CELL_ACTIVATION": "Any process that modulates the frequency, rate, or extent of mast cell activation. [GOC:mah]", "GOBP_REGULATION_OF_MAP_KINASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]", "GOBP_REGULATION_OF_MAST_CELL_CHEMOTAXIS": "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. [GOC:mah]", "GOBP_REGULATION_OF_MAST_CELL_DEGRANULATION": "Any process that modulates the frequency, rate, or extent of mast cell degranulation. [ISBN:0781735149]", "GOBP_REGULATION_OF_MATRIX_METALLOPEPTIDASE_SECRETION": "Any process that modulates the frequency, rate or extent of matrix metallopeptidase secretion. [GO_REF:0000058, GOC:TermGenie, PMID:8679543]", "GOBP_REGULATION_OF_MDA_5_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. [GOC:bf, GOC:jl]", "GOBP_REGULATION_OF_MEIOSIS_I": "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_MEIOTIC_CELL_CYCLE_PHASE_TRANSITION": "Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "GOBP_REGULATION_OF_MEIOTIC_CELL_CYCLE": "Any process that modulates the rate or extent of progression through the meiotic cell cycle. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION": "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. [GOC:ems, GOC:ma]", "GOBP_REGULATION_OF_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL": "Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential. [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8]", "GOBP_REGULATION_OF_MELANOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of melanocyte differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_MEMBRANE_INVAGINATION": "Any process that modulates the frequency, rate or extent of membrane invagination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]", "GOBP_REGULATION_OF_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie]", "GOBP_REGULATION_OF_MEMBRANE_DEPOLARIZATION": "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:25954280]", "GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION": "Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. [GOC:mah, PMID:18441123, PMID:20823909]", "GOBP_REGULATION_OF_MEMBRANE_PERMEABILITY": "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. [GOC:kmv, PMID:22677064]", "GOBP_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS": "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:ai]", "GOBP_REGULATION_OF_MEMBRANE_REPOLARIZATION_DURING_ACTION_POTENTIAL": "Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential. [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8]", "GOBP_REGULATION_OF_MEMBRANE_REPOLARIZATION": "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]", "GOBP_REGULATION_OF_MEMBRANE_REPOLARIZATION_DURING_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "Any process that modulates the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015]", "GOBP_REGULATION_OF_MEMBRANE_REPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812]", "GOBP_REGULATION_OF_MEMBRANE_TUBULATION": "Any process that modulates the frequency, rate or extent of membrane tubulation. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313]", "GOBP_REGULATION_OF_MESENCHYMAL_STEM_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation. [GOC:obol]", "GOBP_REGULATION_OF_MEMBRANE_POTENTIAL": "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]", "GOBP_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MESENCHYMAL_TO_EPITHELIAL_TRANSITION_INVOLVED_IN_METANEPHROS_MORPHOGENESIS": "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. [GOC:dph]", "GOBP_REGULATION_OF_MESODERMAL_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]", "GOBP_REGULATION_OF_MESODERM_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of mesoderm development. [GOC:BHF]", "GOBP_REGULATION_OF_MESODERMAL_CELL_FATE_SPECIFICATION": "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification. [GOC:go_curators]", "GOBP_REGULATION_OF_METALLOENDOPEPTIDASE_ACTIVITY": "", "GOBP_REGULATION_OF_MESONEPHROS_DEVELOPMENT": "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]", "GOBP_REGULATION_OF_METALLOPEPTIDASE_ACTIVITY": "", "GOBP_REGULATION_OF_METANEPHROS_DEVELOPMENT": "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. [GOC:mtg_kidney_jan10]", "GOBP_REGULATION_OF_METAPHASE_PLATE_CONGRESSION": "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MICROGLIAL_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of microglial cell activation. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]", "GOBP_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT": "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MICROTUBULE_BINDING": "", "GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS": "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. [GOC:mah]", "GOBP_REGULATION_OF_MICROTUBULE_NUCLEATION": "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MICROTUBULE_CYTOSKELETON_ORGANIZATION": "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah]", "GOBP_REGULATION_OF_MICROTUBULE_DEPOLYMERIZATION": "Any process that modulates the frequency, rate or extent of microtubule depolymerization. [GOC:mah]", "GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION": "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. [GOC:mah]", "GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION": "Any process that modulates the frequency, rate or extent of microtubule polymerization. [GOC:mah]", "GOBP_REGULATION_OF_MICROVILLUS_LENGTH": "A process that modulates the length of a microvillus. [GOC:mah]", "GOBP_REGULATION_OF_MICROVILLUS_ASSEMBLY": "A process that modulates the formation of a microvillus. [GOC:mah]", "GOBP_REGULATION_OF_MICROVILLUS_ORGANIZATION": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. [GOC:mah]", "GOBP_REGULATION_OF_MIRNA_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of miRNA catabolic process. [GOC:dph]", "GOBP_REGULATION_OF_MIRNA_TRANSCRIPTION": "", "GOBP_REGULATION_OF_MIRNA_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of miRNA metabolic process. [GOC:dph]", "GOBP_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION": "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai]", "GOBP_REGULATION_OF_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_ELECTRON_TRANSPORT": "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074]", "GOBP_REGULATION_OF_MITOCHONDRIAL_DNA_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process. [GOC:TermGenie, GOC:yaf, PMID:23150719]", "GOBP_REGULATION_OF_MITOCHONDRIAL_FISSION": "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MITOCHONDRIAL_FUSION": "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE": "Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]", "GOBP_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY": "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. [GOC:bf]", "GOBP_REGULATION_OF_MITOCHONDRIAL_GENE_EXPRESSION": "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [PMID:28285835]", "GOBP_REGULATION_OF_MITOCHONDRIAL_MRNA_STABILITY": "Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs. [GOC:al, GOC:jl]", "GOBP_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL": "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:ai]", "GOBP_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie]", "GOBP_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS": "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]", "GOBP_REGULATION_OF_MITOCHONDRIAL_RNA_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome. [GOC:krc, GOC:mah]", "GOBP_REGULATION_OF_MITOCHONDRIAL_TRANSCRIPTION": "Any process that modulates the frequency, rate or extent of transcription occurring in the mitochondrion. [GO_REF:0000058, GOC:TermGenie, PMID:21357609]", "GOBP_REGULATION_OF_MITOCHONDRIAL_TRANSLATION": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. [GOC:mah]", "GOBP_REGULATION_OF_MITOPHAGY": "", "GOBP_REGULATION_OF_MITOCHONDRION_ORGANIZATION": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MITOTIC_CENTROSOME_SEPARATION": "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis. [GOC:ai]", "GOBP_REGULATION_OF_MITOTIC_CYTOKINESIS": "Any process that modulates the frequency, rate or extent of mitotic cytokinesis. [GOC:mtg_cell_cycle, GOC:TermGenie]", "GOBP_REGULATION_OF_MITOTIC_RECOMBINATION": "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. [GOC:go_curators]", "GOBP_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION": "Any process that modulates the frequency, rate or extent of mitosis. [GOC:go_curators]", "GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE": "Any process that modulates the rate or extent of progress through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_REGULATION_OF_MITOTIC_SPINDLE_ASSEMBLY": "Any process that modulates the frequency, rate or extent of mitotic spindle assembly. [GOC:TermGenie]", "GOBP_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEGREGATION": "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. [GOC:mah]", "GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE_PHASE_TRANSITION": "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "GOBP_REGULATION_OF_MODIFICATION_OF_POSTSYNAPTIC_ACTIN_CYTOSKELETON": "Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton. [GO_REF:0000058, GOC:TermGenie, PMID:21068295]", "GOBP_REGULATION_OF_MODIFICATION_OF_POSTSYNAPTIC_STRUCTURE": "Any process that modulates the frequency, rate or extent of modification of postsynaptic structure. [GOC:dos]", "GOBP_REGULATION_OF_MODIFICATION_OF_SYNAPTIC_STRUCTURE": "Any process that modulates the frequency, rate or extent of modification of synaptic structure. [GO_REF:0000058, GOC:TermGenie, PMID:25164660]", "GOBP_REGULATION_OF_MONOATOMIC_ANION_TRANSMEMBRANE_TRANSPORT": "", "GOBP_REGULATION_OF_MONOATOMIC_ANION_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "GOBP_REGULATION_OF_MONOCYTE_CHEMOTAXIS": "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MONOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of monocyte differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_MONOCYTE_EXTRAVASATION": "Any process that modulates the frequency, rate or extent of monocyte extravasation. [GOC:obol]", "GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. [GOC:mah]", "GOBP_REGULATION_OF_MONOOXYGENASE_ACTIVITY": "", "GOBP_REGULATION_OF_MOLECULAR_FUNCTION": "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GOC:isa_complete]", "GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "GOBP_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION": "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. [GOC:mah]", "GOBP_REGULATION_OF_MORPHOGENESIS_OF_AN_EPITHELIUM": "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]", "GOBP_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE": "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. [GOC:dph]", "GOBP_REGULATION_OF_MOTOR_NEURON_APOPTOTIC_PROCESS": "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. [GOC:mtg_apoptosis, GOC:obol]", "GOBP_REGULATION_OF_MRNA_3_END_PROCESSING": "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. [GOC:mah]", "GOBP_REGULATION_OF_MRNA_CIS_SPLICING_VIA_SPLICEOSOME": "", "GOBP_REGULATION_OF_MRNA_EXPORT_FROM_NUCLEUS": "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS": "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MUCUS_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. [GOC:add]", "GOBP_REGULATION_OF_MRNA_PROCESSING": "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. [GOC:ai]", "GOBP_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME": "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. [GOC:jid]", "GOBP_REGULATION_OF_MRNA_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of mRNA metabolic process. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH": "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. [GOC:dph, GOC:ems, GOC:tb]", "GOBP_REGULATION_OF_MUSCLE_ADAPTATION": "Any process that modulates the frequency, rate or extent of muscle adaptation. [GOC:go_curators, GOC:mtg_muscle]", "GOBP_REGULATION_OF_MUSCLE_CONTRACTION": "Any process that modulates the frequency, rate or extent of muscle contraction. [GOC:go_curators]", "GOBP_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of muscle cell differentiation. [CL:0000187, GOC:ai]", "GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of multicellular organismal development. [GOC:obol]", "GOBP_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT": "", "GOBP_REGULATION_OF_MUSCLE_HYPERTROPHY": "Any process that modulates the frequency, rate or extent of muscle hypertrophy. [GOC:mtg_muscle]", "GOBP_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of muscle development. [GOC:go_curators]", "GOBP_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS": "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_MYELINATION": "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]", "GOBP_REGULATION_OF_MUSCLE_SYSTEM_PROCESS": "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_MYELOID_DENDRITIC_CELL_ACTIVATION": "Any process that modulates the frequency or rate of myeloid dendritic cell activation. [GOC:mah]", "GOBP_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of myeloid cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_MYOBLAST_PROLIFERATION": "Any process that modulates the frequency, rate or extent of myoblast proliferation. [GOC:mah]", "GOBP_REGULATION_OF_MYOBLAST_FUSION": "", "GOBP_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. [GOC:add]", "GOBP_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY": "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. [GOC:add]", "GOBP_REGULATION_OF_MYOBLAST_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]", "GOBP_REGULATION_OF_MYOFIBROBLAST_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of myofibroblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]", "GOBP_REGULATION_OF_MYOSIN_LIGHT_CHAIN_PHOSPHATASE_ACTIVITY": "", "GOBP_REGULATION_OF_MYOTUBE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_NAD_P_H_OXIDASE_ACTIVITY": "", "GOBP_REGULATION_OF_NADP_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of NADP metabolic process. [GOC:TermGenie, PMID:23334421]", "GOBP_REGULATION_OF_NATURAL_KILLER_CELL_CHEMOTAXIS": "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis. [GOC:BHF]", "GOBP_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL": "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. [GOC:add]", "GOBP_REGULATION_OF_NATURAL_KILLER_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of natural killer cell differentiation. [GOC:mah]", "GOBP_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of natural killer cell activation. [GOC:mah]", "GOBP_REGULATION_OF_NATURAL_KILLER_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of natural killer cell proliferation. [GOC:mah]", "GOBP_REGULATION_OF_NERVOUS_SYSTEM_PROCESS": "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. [GOC:dph, GOC:mah, GOC:tb]", "GOBP_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY": "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. [GOC:add]", "GOBP_REGULATION_OF_NEUROBLAST_PROLIFERATION": "Any process that modulates the frequency, rate or extent of neuroblast proliferation. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496]", "GOBP_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. [GOC:dph, GOC:yaf]", "GOBP_REGULATION_OF_NEUROMUSCULAR_JUNCTION_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of neuromuscular junction development. [GO_REF:0000058, GOC:TermGenie, PMID:7722643]", "GOBP_REGULATION_OF_NEUROINFLAMMATORY_RESPONSE": "Any process that modulates the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]", "GOBP_REGULATION_OF_NEURONAL_ACTION_POTENTIAL": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:dph, GOC:isa_complete, GOC:tb]", "GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. [GOC:ai]", "GOBP_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY": "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:jid, PMID:11891290]", "GOBP_REGULATION_OF_NEUROGENESIS": "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. [GOC:ai]", "GOBP_REGULATION_OF_NEURON_MATURATION": "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. [GOC:ef]", "GOBP_REGULATION_OF_NEURON_APOPTOTIC_PROCESS": "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]", "GOBP_REGULATION_OF_NEURON_MIGRATION": "Any process that modulates the frequency, rate or extent of neuron migration. [GOC:obol]", "GOBP_REGULATION_OF_NEURON_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of neuron differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_NEURON_PROJECTION_ARBORIZATION": "Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. [GOC:aruk, GOC:bc, PMID:17114044]", "GOBP_REGULATION_OF_NEURON_PROJECTION_REGENERATION": "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. [GOC:mah]", "GOBP_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_LOCALIZATION_TO_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE": "Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. [GOC:dos]", "GOBP_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY": "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors. [GOC:dos]", "GOBP_REGULATION_OF_NEUROTRANSMITTER_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. [GOC:ai]", "GOBP_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT": "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. [GOC:ai]", "GOBP_REGULATION_OF_NEUTROPHIL_ACTIVATION": "Any process that modulates the frequency, rate or extent of neutrophil activation. [GOC:TermGenie, PMID:17588661]", "GOBP_REGULATION_OF_NEUROTRANSMITTER_UPTAKE": "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. [GOC:ai]", "GOBP_REGULATION_OF_NEUTROPHIL_DEGRANULATION": "Any process that modulates the frequency, rate, or extent of neutrophil degranulation. [ISBN:0781735149]", "GOBP_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS": "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_NEUTROPHIL_EXTRAVASATION": "Any process that modulates the frequency, rate or extent of neutrophil extravasation. [GOC:mah]", "GOBP_REGULATION_OF_NEUTROPHIL_MEDIATED_CYTOTOXICITY": "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil. [GOC:add, GOC:mah]", "GOBP_REGULATION_OF_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION": "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_NEUTROPHIL_MIGRATION": "Any process that modulates the frequency, rate or extent of neutrophil migration. [GO_REF:0000058, GOC:TermGenie, PMID:1826836]", "GOBP_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:DHL]", "GOBP_REGULATION_OF_NK_T_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation. [ISBN:0781735149, PMID:12154375, PMID:9133426]", "GOBP_REGULATION_OF_NK_T_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of natural killer T cell activation. [ISBN:0781735149, PMID:12154375, PMID:9133426]", "GOBP_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY": "Any process that modulates the activity of the enzyme nitric-oxide synthase. [GOC:ai]", "GOBP_REGULATION_OF_NODAL_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of nodal signaling pathway. [GOC:BHF, GOC:TermGenie, GOC:vk]", "GOBP_REGULATION_OF_NK_T_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation. [ISBN:0781735149, PMID:12154375, PMID:9133426]", "GOBP_REGULATION_OF_NMDA_RECEPTOR_ACTIVITY": "", "GOBP_REGULATION_OF_NON_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION": "Any process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade. [GOC:TermGenie]", "GOBP_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. [GOC:obol, GOC:yaf]", "GOBP_REGULATION_OF_NON_MOTILE_CILIUM_ASSEMBLY": "Any process that modulates the frequency, rate or extent of non-motile cilium assembly. [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208]", "GOBP_REGULATION_OF_NOTCH_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]", "GOBP_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY": "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. [GOC:obol]", "GOBP_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION": "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. [GOC:mtg_cell_cycle]", "GOBP_REGULATION_OF_NUCLEASE_ACTIVITY": "", "GOBP_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING": "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_NUCLEAR_DIVISION": "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. [GOC:ai]", "GOBP_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY": "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie]", "GOBP_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_REGULATION_OF_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway. [GOC:add]", "GOBP_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. [GOC:bf]", "GOBP_REGULATION_OF_NUCLEOTIDE_BINDING_OLIGOMERIZATION_DOMAIN_CONTAINING_2_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway. [GOC:add]", "GOBP_REGULATION_OF_NUCLEOTIDE_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. [GOC:mah]", "GOBP_REGULATION_OF_NUCLEOTIDE_EXCISION_REPAIR": "Any process that modulates the frequency, rate or extent of nucleotide-excision repair. [GOC:jp, PMID:18836076]", "GOBP_REGULATION_OF_ODONTOGENESIS": "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. [GOC:jl]", "GOBP_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS": "", "GOBP_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. [GOC:go_curators]", "GOBP_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH": "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. [GOC:jl, GOC:mtg_sensu, PMID:15355794]", "GOBP_REGULATION_OF_ODONTOBLAST_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of odontoblast differentiation. [GOC:TermGenie]", "GOBP_REGULATION_OF_OPSIN_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of opsin-mediated signaling. [GOC:mah]", "GOBP_REGULATION_OF_OOCYTE_MATURATION": "Any process that modulates the frequency, rate or extent of oocyte maturation. [GOC:kmv, GOC:TermGenie]", "GOBP_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. [GOC:vp, PMID:15139015]", "GOBP_REGULATION_OF_OPSONIZATION": "Any process that modulates the frequency, rate or extent of opsonization. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221]", "GOBP_REGULATION_OF_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE": "Any process that modulates the frequency, rate or extent of organelle transport along microtubule. [GOC:dph, GOC:TermGenie, PMID:21147087]", "GOBP_REGULATION_OF_ORGANELLE_ASSEMBLY": "Any process that modulates the frequency, rate or extent of organelle assembly. [GOC:pr, GOC:TermGenie]", "GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_REGULATION_OF_ORGAN_GROWTH": "Any process that modulates the frequency, rate or extent of growth of an organ of an organism. [GOC:bf, GOC:tb]", "GOBP_REGULATION_OF_OSTEOBLAST_PROLIFERATION": "Any process that modulates the frequency, rate or extent of osteoblast proliferation. [GOC:mah]", "GOBP_REGULATION_OF_OSTEOCLAST_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of osteoclast development. [GOC:obol]", "GOBP_REGULATION_OF_OSSIFICATION": "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]", "GOBP_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_OSTEOCLAST_PROLIFERATION": "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. [GOC:tb]", "GOBP_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_ORGANELLE_ORGANIZATION": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:mah]", "GOBP_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. [GOC:dph]", "GOBP_REGULATION_OF_OVARIAN_FOLLICLE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of ovarian follicle development. [GOC:obol]", "GOBP_REGULATION_OF_PANCREATIC_JUICE_SECRETION": "Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]", "GOBP_REGULATION_OF_PEPTIDASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:ai]", "GOBP_REGULATION_OF_PENTOSE_PHOSPHATE_SHUNT": "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis. [GOC:jl]", "GOBP_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:ai]", "GOBP_REGULATION_OF_P38MAPK_CASCADE": "Any process that modulates the frequency, rate or extent of p38MAPK cascade. [GOC:TermGenie]", "GOBP_REGULATION_OF_PEPTIDYL_LYSINE_ACETYLATION": "", "GOBP_REGULATION_OF_PEPTIDYL_CYSTEINE_S_NITROSYLATION": "", "GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway. [PMID:30610168]", "GOBP_REGULATION_OF_PEPTIDE_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PEPTIDYL_SERINE_DEPHOSPHORYLATION": "", "GOBP_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION": "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]", "GOBP_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION": "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE": "Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210]", "GOBP_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION": "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]", "GOBP_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. [GOC:bf]", "GOBP_REGULATION_OF_PHENOTYPIC_SWITCHING": "Any process that modulates the frequency, rate or extent of phenotypic switching. [GOC:di, GOC:TermGenie]", "GOBP_REGULATION_OF_PHAGOCYTOSIS": "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. [GOC:ai]", "GOBP_REGULATION_OF_PH": "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. [GOC:dph, GOC:go_curators, GOC:tb]", "GOBP_REGULATION_OF_PHOSPHATE_TRANSPORT": "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PHOSPHATASE_ACTIVITY": "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing phosphate. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process. [GOC:obol]", "GOBP_REGULATION_OF_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. [GOC:dph, GOC:tb, GOC:vw]", "GOBP_REGULATION_OF_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process. [GOC:aruk, GOC:bc, PMID:30074985]", "GOBP_REGULATION_OF_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION": "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY": "", "GOBP_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY": "", "GOBP_REGULATION_OF_PHOSPHOLIPID_CATABOLIC_PROCESS": "Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. [GOC:mah]", "GOBP_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY": "", "GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of phospholipid metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10657240]", "GOBP_REGULATION_OF_PHOSPHOLIPID_TRANSLOCATION": "Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. [GOC:dph, GOC:jh, GOC:tb, PMID:19966303]", "GOBP_REGULATION_OF_PHOSPHOLIPID_TRANSPORT": "", "GOBP_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY": "", "GOBP_REGULATION_OF_PIGMENTATION": "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. [GOC:krc]", "GOBP_REGULATION_OF_PINOCYTOSIS": "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]", "GOBP_REGULATION_OF_PIGMENT_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of pigmented cell differentiation. [GOC:ai]", "GOBP_REGULATION_OF_PLASMA_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of plasma cell differentiation. [GOC:TermGenie]", "GOBP_REGULATION_OF_PHOSPHORYLATION": "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. [GOC:jl]", "GOBP_REGULATION_OF_PLASMA_MEMBRANE_REPAIR": "Any process that modulates the frequency, rate or extent of plasma membrane repair. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]", "GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS": "Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. [GOC:BHF]", "GOBP_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION": "Any process that modulates the frequency, rate or extent of plasma membrane organization. [GO_REF:0000058, GOC:TermGenie, PMID:24514900]", "GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. [GOC:ai]", "GOBP_REGULATION_OF_PLASMINOGEN_ACTIVATION": "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PLATELET_ACTIVATION": "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PLATELET_AGGREGATION": "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_ALPHA_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway. [GOC:obol]", "GOBP_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BETA_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. [GOC:obol]", "GOBP_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb]", "GOBP_REGULATION_OF_POLYAMINE_TRANSMEMBRANE_TRANSPORT": "Any process that modulates the frequency, rate or extent of polyamine transmembrane transport. [GOC:TermGenie, PMID:23755272]", "GOBP_REGULATION_OF_PODOSOME_ASSEMBLY": "Any process that modulates the frequency, rate or extent of podosome assembly. [GOC:mah, GOC:sl]", "GOBP_REGULATION_OF_POSITIVE_CHEMOTAXIS": "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]", "GOBP_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. [GOC:mah]", "GOBP_REGULATION_OF_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. [GOC:mah]", "GOBP_REGULATION_OF_POSTSYNAPSE_ASSEMBLY": "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854]", "GOBP_REGULATION_OF_POSTSYNAPTIC_DENSITY_ASSEMBLY": "Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density. [GOC:dos]", "GOBP_REGULATION_OF_POSTSYNAPTIC_CYTOSOLIC_CALCIUM_ION_CONCENTRATION": "Any process that regulates the concentration of calcium in the postsynaptic cytosol. [GOC:dos]", "GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION": "Any process that modulates the physical form of a postsynapse. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_POSTSYNAPTIC_DENSITY_ORGANIZATION": "Any process that modulates the frequency, rate or extent of postsynaptic density organization. [GO_REF:0000058, GOC:TermGenie, PMID:21887379]", "GOBP_REGULATION_OF_POSTSYNAPTIC_NEUROTRANSMITTER_RECEPTOR_ACTIVITY": "", "GOBP_REGULATION_OF_POSTSYNAPTIC_NEUROTRANSMITTER_RECEPTOR_INTERNALIZATION": "Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse. [GOC:ai]", "GOBP_REGULATION_OF_POSTSYNAPTIC_SPECIALIZATION_ASSEMBLY": "Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization. [GOC:dos]", "GOBP_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_NEUROTRANSMITTER_RECEPTOR_LEVELS": "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane. [GOC:dos]", "GOBP_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL": "Any process that modulates the potential difference across a post-synaptic membrane. [GOC:dph, GOC:ef]", "GOBP_REGULATION_OF_POTASSIUM_ION_IMPORT": "Any process that modulates the frequency, rate or extent of potassium ion import. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900]", "GOBP_REGULATION_OF_POTASSIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE": "Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]", "GOBP_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOBP_REGULATION_OF_POST_TRANSLATIONAL_PROTEIN_MODIFICATION": "Any process that modulates the frequency, rate or extent of post-translational protein modification. [GOC:TermGenie, GOC:yaf, PMID:21209915]", "GOBP_REGULATION_OF_POTASSIUM_ION_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "GOBP_REGULATION_OF_PRESYNAPTIC_CYTOSOLIC_CALCIUM_ION_CONCENTRATION": "Any process that regulates the concentration of calcium in the presynaptic cytosol. [GOC:dos]", "GOBP_REGULATION_OF_PRESYNAPSE_ORGANIZATION": "Any process that modulates the physical form of a presynapse. [GOC:ai, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PRESYNAPTIC_MEMBRANE_POTENTIAL": "Any process that modulates the potential difference across a presynaptic membrane. [GOC:dph, GOC:ef]", "GOBP_REGULATION_OF_PRE_MIRNA_PROCESSING": "Any process that modulates the frequency, rate or extent of pre-microRNA processing. [GOC:dph, GOC:sl]", "GOBP_REGULATION_OF_PRIMARY_MIRNA_PROCESSING": "Any process that modulates the frequency, rate or extent of primary microRNA processing. [GOC:dph, GOC:sl]", "GOBP_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. [GOC:add]", "GOBP_REGULATION_OF_PROGRAMMED_NECROTIC_CELL_DEATH": "Any process that modulates the frequency, rate or extent of programmed necrotic cell death. [GOC:aruk, GOC:rph, PMID:27258785]", "GOBP_REGULATION_OF_PROSTATIC_BUD_FORMATION": "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. [GOC:dph]", "GOBP_REGULATION_OF_PROSTAGLANDIN_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:mah]", "GOBP_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS": "", "GOBP_REGULATION_OF_PROTEIN_ADP_RIBOSYLATION": "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PROTEIN_ACETYLATION": "Any process that modulates the frequency, rate or extent of protein acetylation. [GOC:TermGenie, PMID:22117195]", "GOBP_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]", "GOBP_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION": "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. [GOC:mah]", "GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH": "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. [GOC:jl]", "GOBP_REGULATION_OF_PROTEIN_AUTOUBIQUITINATION": "Any process that modulates the frequency, rate or extent of protein autoubiquitination. [GOC:rb, GOC:TermGenie, PMID:24069405]", "GOBP_REGULATION_OF_PROTEIN_COMPLEX_STABILITY": "Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly. [GOC:dph]", "GOBP_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS_IN_THE_VACUOLE": "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]", "GOBP_REGULATION_OF_PROTEIN_BINDING": "Any process that modulates the frequency, rate or extent of protein binding. [GOC:go_curators]", "GOBP_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators, GOC:jl]", "GOBP_REGULATION_OF_PROTEIN_DEPHOSPHORYLATION": "", "GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY": "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. [GOC:jl]", "GOBP_REGULATION_OF_PROTEIN_DEACETYLATION": "Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:tb]", "GOBP_REGULATION_OF_PROTEIN_DEUBIQUITINATION": "Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY": "Any process that modulates the frequency, rate or extent of protein complex assembly. [GOC:jl]", "GOBP_REGULATION_OF_PROTEIN_DEPOLYMERIZATION": "Any process that modulates the frequency, rate or extent of protein depolymerization. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]", "GOBP_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS": "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. [GOC:bf]", "GOBP_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM": "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. [GOC:mah]", "GOBP_REGULATION_OF_PROTEIN_FOLDING": "Any process that modulates the frequency, rate or extent of protein folding. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_REGULATION_OF_PROTEIN_GLYCOSYLATION": "", "GOBP_REGULATION_OF_PROTEIN_K48_LINKED_UBIQUITINATION": "Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. [PMID:23460740]", "GOBP_REGULATION_OF_PROTEIN_K63_LINKED_UBIQUITINATION": "Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination. [GOC:TermGenie]", "GOBP_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS": "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. [GOC:jl]", "GOBP_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING": "", "GOBP_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING": "Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PROTEIN_KINASE_C_ACTIVITY": "", "GOBP_REGULATION_OF_PROTEIN_LIPIDATION": "Any process that modulates the frequency, rate or extent of protein lipidation. [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_CORTEX": "Any process that modulates the frequency, rate or extent of protein localization to cell cortex. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CENTROSOME": "Any process that modulates the frequency, rate or extent of protein localization to centrosome. [GO_REF:0000058, GOC:TermGenie, PMID:17115027]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE": "Any process that modulates the frequency, rate or extent of protein localization to the cell surface. [GOC:obol]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMATIN": "Any process that modulates the frequency, rate or extent of protein localization to chromatin. [GO_REF:0000058, GOC:TermGenie, PMID:20889714]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY": "Any process that modulates the frequency, rate or extent of protein localization to cell periphery. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CILIUM": "Any process that modulates the frequency, rate or extent of protein localization to cilium. [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION": "", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_ENDOSOME": "Any process that modulates the frequency, rate or extent of protein localization to endosome. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_LYSOSOME": "Any process that modulates the frequency, rate or extent of protein localization to lysosome. [GOC:aruk, GOC:bc, PMID:24305806]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEOLUS": "Any process that modulates the frequency, rate or extent of protein localization to nucleolus. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_SYNAPSE": "Any process that modulates the frequency, rate or extent of protein localization to synapse. [GOC:kmv, GOC:TermGenie, PMID:22588719]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE": "Any process that modulates the frequency, rate or extent of protein localization to membrane. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]", "GOBP_REGULATION_OF_PROTEIN_MATURATION": "Any process that modulates the frequency, rate or extent of protein maturation. [GO_REF:0000058, GOC:TermGenie, GOC:vw]", "GOBP_REGULATION_OF_PROTEIN_MONOUBIQUITINATION": "Any process that modulates the frequency, rate or extent of protein monoubiquitination. [GOC:TermGenie, PMID:21931591]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE": "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]", "GOBP_REGULATION_OF_PROTEIN_NEDDYLATION": "Any process that modulates the frequency, rate or extent of protein neddylation. [GOC:obol]", "GOBP_REGULATION_OF_PROTEIN_OLIGOMERIZATION": "Any process that modulates the frequency, rate or extent of protein oligomerization. [GOC:mah]", "GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS": "Any process that modulates the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]", "GOBP_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS": "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. [GOC:mah, GOC:tb]", "GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION": "Any process that modulates the frequency, rate or extent of the process of creating protein polymers. [GOC:mah]", "GOBP_REGULATION_OF_PROTEIN_POLYUBIQUITINATION": "Any process that modulates the frequency, rate or extent of protein polyubiquitination. [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667]", "GOBP_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY": "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:mah]", "GOBP_REGULATION_OF_PROTEIN_SUMOYLATION": "Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. [GOC:mah]", "GOBP_REGULATION_OF_PROTEIN_SECRETION": "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai]", "GOBP_REGULATION_OF_PROTEIN_TARGETING": "Any process that modulates the frequency, rate or extent of protein targeting. [GO_REF:0000058, GOC:TermGenie]", "GOBP_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE": "Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb]", "GOBP_REGULATION_OF_PROTEIN_STABILITY": "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. [GOC:dph, GOC:mah, GOC:tb]", "GOBP_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY": "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_PROTEIN_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_REGULATION_OF_PROTON_TRANSPORT": "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:sm]", "GOBP_REGULATION_OF_PROTEIN_UBIQUITINATION": "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]", "GOBP_REGULATION_OF_PRO_B_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of pro-B cell differentiation. [GOC:obol]", "GOBP_REGULATION_OF_RAB_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that modulates the frequency, rate or extent of Rab protein signal transduction. [GOC:mah]", "GOBP_REGULATION_OF_PROTEOLYSIS_INVOLVED_IN_PROTEIN_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]", "GOBP_REGULATION_OF_PROTEOLYSIS": "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:mah]", "GOBP_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that modulates the frequency, rate or extent of Rac protein signal transduction. [GOC:bf]", "GOBP_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that modulates the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]", "GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]", "GOBP_REGULATION_OF_RECEPTOR_BINDING": "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. [GOC:signaling, GOC:TermGenie]", "GOBP_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of receptor catabolic process. [GOC:BHF]", "GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]", "GOBP_REGULATION_OF_RECEPTOR_CLUSTERING": "Any process that modulates the frequency, rate or extent of receptor clustering. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]", "GOBP_REGULATION_OF_RECEPTOR_LOCALIZATION_TO_SYNAPSE": "Any process that modulates the frequency, rate or extent of receptor localization to synapse. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]", "GOBP_REGULATION_OF_RECEPTOR_INTERNALIZATION": "Any process that modulates the frequency, rate or extent of receptor internalization. [GOC:hjd]", "GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS": "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators, GOC:tb]", "GOBP_REGULATION_OF_RECEPTOR_RECYCLING": "Any process that modulates the frequency, rate, or extent of receptor recycling. [GOC:add]", "GOBP_REGULATION_OF_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT": "Any process that modulates the frequency, rate or extent of receptor signaling via STAT. [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195]", "GOBP_REGULATION_OF_REGULATORY_NCRNA_PROCESSING": "Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing. [GOC:mah]", "GOBP_REGULATION_OF_RELAXATION_OF_CARDIAC_MUSCLE": "Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]", "GOBP_REGULATION_OF_REGULATED_SECRETORY_PATHWAY": "Any process that modulates the frequency, rate or extent of regulated secretory pathway. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]", "GOBP_REGULATION_OF_RELAXATION_OF_MUSCLE": "Any process that modulates the frequency, rate or extent of relaxation of muscle. [GOC:TermGenie]", "GOBP_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS": "Any process that modulates the frequency, rate or extent of removal of superoxide radicals. [GOC:obol]", "GOBP_REGULATION_OF_RENAL_SODIUM_EXCRETION": "Any process that modulates the amount of sodium excreted in urine over a unit of time. [GOC:mtg_25march11, GOC:yaf]", "GOBP_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL": "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai, GOC:tb]", "GOBP_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA": "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM": "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_RENAL_SYSTEM_PROCESS": "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. [GOC:dos]", "GOBP_REGULATION_OF_RESPIRATORY_BURST": "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE": "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. [GOC:jl]", "GOBP_REGULATION_OF_RESPIRATORY_BURST_INVOLVED_IN_INFLAMMATORY_RESPONSE": "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]", "GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS": "Any process that modulates the frequency, rate or extent of reproductive process. [GOC:mah]", "GOBP_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NERVOUS_SYSTEM_PROCESS": "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. [GOC:dph, GOC:tb, PMID:12458206]", "GOBP_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS": "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. [GOC:jl]", "GOBP_REGULATION_OF_RESPONSE_TO_DRUG": "Any process that modulates the frequency, rate or extent of response to drug. [GOC:obol]", "GOBP_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450]", "GOBP_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS": "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_RESPONSE_TO_FOOD": "Any process that modulates the frequency, rate or extent of a response to a food stimulus. [GOC:add]", "GOBP_REGULATION_OF_RESPONSE_TO_OSMOTIC_STRESS": "Any process that modulates the rate or extent of the response to osmotic stress. [GOC:ai]", "GOBP_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS": "Any process that modulates the frequency, rate or extent of a response to nutrient levels. [GOC:mah]", "GOBP_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES": "Any process that modulates the frequency, rate or extent of response to reactive oxygen species. [GOC:kmv, GOC:TermGenie]", "GOBP_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS": "Any process that modulates the frequency, rate or extent of response to oxidative stress. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]", "GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS": "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. [GOC:add]", "GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS": "Any process that modulates the frequency, rate or extent of a response to an external stimulus. [GOC:mah]", "GOBP_REGULATION_OF_RESPONSE_TO_TYPE_II_INTERFERON": "Any process that modulates the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. [GOC:dph]", "GOBP_REGULATION_OF_RESPONSE_TO_TUMOR_CELL": "Any process that modulates the frequency, rate, or extent of a response to tumor cell. [GOC:add]", "GOBP_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. [GOC:dgh]", "GOBP_REGULATION_OF_RESTING_MEMBRANE_POTENTIAL": "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized. [GOC:dph, GOC:ef, ISBN:0195088433]", "GOBP_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL": "Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783]", "GOBP_REGULATION_OF_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI": "Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23395371]", "GOBP_REGULATION_OF_RESPONSE_TO_WOUNDING": "Any process that modulates the frequency, rate or extent of response to wounding. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535]", "GOBP_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that modulates the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]", "GOBP_REGULATION_OF_RESPONSE_TO_STRESS": "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:dhl]", "GOBP_REGULATION_OF_RIBONUCLEASE_ACTIVITY": "", "GOBP_REGULATION_OF_RIBOSOME_BIOGENESIS": "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_RIG_I_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway. [GOC:bf, GOC:jl]", "GOBP_REGULATION_OF_RNA_BINDING": "", "GOBP_REGULATION_OF_RNA_EXPORT_FROM_NUCLEUS": "", "GOBP_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION_PREINITIATION_COMPLEX_ASSEMBLY": "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. [GOC:go_curators]", "GOBP_REGULATION_OF_RNA_POLYMERASE_II_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING": "", "GOBP_REGULATION_OF_RRNA_PROCESSING": "Any process that modulates the frequency, rate or extent of rRNA processing. [GOC:mah]", "GOBP_REGULATION_OF_RUFFLE_ASSEMBLY": "Any process that modulates the frequency, rate or extent of ruffle assembly. [GOC:TermGenie, GOC:yaf]", "GOBP_REGULATION_OF_RNA_SPLICING": "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. [GOC:jl]", "GOBP_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY": "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SARCOMERE_ORGANIZATION": "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SALIVA_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue. [GOC:ai]", "GOBP_REGULATION_OF_SECONDARY_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. [GOC:jl]", "GOBP_REGULATION_OF_SECONDARY_HEART_FIELD_CARDIOBLAST_PROLIFERATION": "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract). [GOC:mtg_heart, GOC:rl, PMID:17276708]", "GOBP_REGULATION_OF_SENSORY_PERCEPTION": "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. [GOC:ai]", "GOBP_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE": "", "GOBP_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY": "", "GOBP_REGULATION_OF_SEROTONIN_SECRETION": "Any process that modulates the frequency, rate or extent of the regulated release of serotonin. [GOC:ef]", "GOBP_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY": "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. [GOC:jid, PMID:11891290]", "GOBP_REGULATION_OF_SECRETION": "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. [GOC:ai]", "GOBP_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR": "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]", "GOBP_REGULATION_OF_SIGNALING_RECEPTOR_ACTIVITY": "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SISTER_CHROMATID_COHESION": "Any process that modulates the frequency, rate or extent of sister chromatid cohesion. [GOC:go_curators]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_ACETYLCHOLINE_GATED_CHANNEL_CLUSTERING": "Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering. [GO_REF:0000058, GOC:TermGenie, PMID:7722643]", "GOBP_REGULATION_OF_SISTER_CHROMATID_SEGREGATION": "Any process that modulates the frequency, rate or extent of sister chromatid segregation. [GOC:mah]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION": "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. [GOC:obol]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. [CL:0000188, GOC:ef, GOC:mtg_muscle]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction. [GOC:ef, GOC:mtg_muscle]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction. [GOC:mtg_muscle]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION_BY_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION": "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:mtg_muscle]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_SATELLITE_CELL_PROLIFERATION": "", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. [GOC:go_curators]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_FIBER_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_GROWTH": "Any process that modulates the frequency, rate or extent of skeletal muscle growth. [GOC:lm, PMID:15726494, PMID:15907921]", "GOBP_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_REGENERATION": "Any process that modulates the frequency, rate or extent of skeletal muscle. [GOC:jl]", "GOBP_REGULATION_OF_SMAD_PROTEIN_SIGNAL_TRANSDUCTION": "Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of smoothened signaling. [GOC:go_curators]", "GOBP_REGULATION_OF_SMOOTH_MUSCLE_CELL_CHEMOTAXIS": "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis. [GOC:mah]", "GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION": "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:go_curators]", "GOBP_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. [CL:0000192, GOC:ai]", "GOBP_REGULATION_OF_SNARE_COMPLEX_ASSEMBLY": "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb]", "GOBP_REGULATION_OF_SODIUM_DEPENDENT_PHOSPHATE_TRANSPORT": "Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport. [GOC:BHF]", "GOBP_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION": "Any process that modulates the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators]", "GOBP_REGULATION_OF_SNRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_II": "Any process that modulates the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900]", "GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS": "Any process that modulates the rate, frequency or extent of a small molecule metabolic process. [GOC:vw]", "GOBP_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT": "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]", "GOBP_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]", "GOBP_REGULATION_OF_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE": "Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]", "GOBP_REGULATION_OF_SODIUM_ION_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph]", "GOBP_REGULATION_OF_SPERM_CAPACITATION": "Any process that modulates the frequency, rate or extent of sperm capacitation. [GOC:hjd, GOC:TermGenie, PMID:22539676]", "GOBP_REGULATION_OF_SOMITOGENESIS": "Any process that modulates the frequency, rate or extent of somitogenesis. [GOC:mtg_muscle]", "GOBP_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS": "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SPINDLE_ASSEMBLY": "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SPINDLE_CHECKPOINT": "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SPONTANEOUS_SYNAPTIC_TRANSMISSION": "Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission. [GOC:aruk, GOC:bc, PMID:15457210]", "GOBP_REGULATION_OF_SPINDLE_ORGANIZATION": "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SPROUTING_ANGIOGENESIS": "Any process that modulates the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958]", "GOBP_REGULATION_OF_SREBP_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the SREBP signaling pathway. [GOC:BHF]", "GOBP_REGULATION_OF_STEM_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of stem cell differentiation. [GOC:obol]", "GOBP_REGULATION_OF_STEM_CELL_DIVISION": "Any process that modulates the frequency, rate or extent of stem cell division. [GOC:obol]", "GOBP_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE": "Any process that modulates the frequency, rate or extent of stem cell population maintenance. [GOC:obol]", "GOBP_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:ai]", "GOBP_REGULATION_OF_STEROID_HORMONE_SECRETION": "Any process that modulates the frequency, rate or extent of steroid hormone secretion. [GOC:sl]", "GOBP_REGULATION_OF_STEM_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [GOC:mtg_kidney_jan10]", "GOBP_REGULATION_OF_STEROID_HORMONE_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY": "Any process that modulates the frequency, rate or extent of store-operated calcium channel activity. [GOC:TermGenie]", "GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators]", "GOBP_REGULATION_OF_STORE_OPERATED_CALCIUM_ENTRY": "Any process that modulates the frequency, rate or extent of store-operated calcium entry. [GOC:BHF]", "GOBP_REGULATION_OF_STEROL_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE": "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. [GOC:mah]", "GOBP_REGULATION_OF_STRESS_GRANULE_ASSEMBLY": "Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. [PMID:20180778]", "GOBP_REGULATION_OF_STRIATED_MUSCLE_TISSUE_DEVELOPMENT": "", "GOBP_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION": "Any process that modulates the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]", "GOBP_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING": "Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. [GOC:TermGenie, GOC:yaf]", "GOBP_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. [CL:0000737, GOC:ai]", "GOBP_REGULATION_OF_SULFUR_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. [GOC:go_curators]", "GOBP_REGULATION_OF_SUPEROXIDE_ANION_GENERATION": "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. [GOC:mah]", "GOBP_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS": "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. [GOC:tb]", "GOBP_REGULATION_OF_SYNAPSE_MATURATION": "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION": "Any process that modulates the frequency, rate or extent of supramolecular fiber organization. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]", "GOBP_REGULATION_OF_SYNAPSE_ASSEMBLY": "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]", "GOBP_REGULATION_OF_SYNAPSE_STRUCTURAL_PLASTICITY": "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane. [PMID:11063967, PMID:14976517, PMID:9884123]", "GOBP_REGULATION_OF_SYNAPSE_PRUNING": "Any process that modulates the frequency, rate or extent of synapse pruning. [GO_REF:0000058, GOC:TermGenie, PMID:27779093]", "GOBP_REGULATION_OF_SYNAPTIC_ASSEMBLY_AT_NEUROMUSCULAR_JUNCTION": "Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions. [GOC:go_curators]", "GOBP_REGULATION_OF_SYNAPTIC_TRANSMISSION_CHOLINERGIC": "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. [GOC:mah]", "GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY": "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai]", "GOBP_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC": "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. [GOC:mah]", "GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY": "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]", "GOBP_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC": "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]", "GOBP_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC": "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]", "GOBP_REGULATION_OF_SYNAPTIC_VESICLE_ENDOCYTOSIS": "Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_SYNAPTIC_VESICLE_CLUSTERING": "Any process that modulates the frequency, rate or extent of synaptic vesicle clustering. [PMID:21513708]", "GOBP_REGULATION_OF_SYNAPTIC_VESICLE_CYCLE": "Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. [GOC:dos]", "GOBP_REGULATION_OF_SYNAPTIC_VESICLE_MEMBRANE_ORGANIZATION": "Any process that modulates the frequency, rate or extent of synaptic vesicle membrane organization. [GOC:TermGenie, PMID:22426000]", "GOBP_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS": "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol]", "GOBP_REGULATION_OF_SYNAPTIC_VESICLE_PRIMING": "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511]", "GOBP_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING": "Any process that modulates the frequency, rate or extent of synaptic vesicle recycling. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]", "GOBP_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT": "Any process that modulates the frequency, rate or extent of synaptic vesicle transport. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112]", "GOBP_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION": "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. [GOC:dph]", "GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN": "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. [ISBN:0721643949]", "GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_ENDOTHELIN": "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor. [GOC:mtg_cardio]", "GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE": "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:mtg_cardio]", "GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_NOREPINEPHRINE_EPINEPHRINE": "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system. [ISBN:0721643949]", "GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE": "", "GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN": "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. [GOC:mtg_cardio]", "GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_VASOPRESSIN": "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. [GOC:mtg_cardio, ISBN:0721643949]", "GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL": "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. [GOC:mtg_cardio]", "GOBP_REGULATION_OF_TAU_PROTEIN_KINASE_ACTIVITY": "", "GOBP_REGULATION_OF_TELOMERASE_ACTIVITY": "", "GOBP_REGULATION_OF_TELOMERE_CAPPING": "Any process that modulates the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "GOBP_REGULATION_OF_TELOMERE_MAINTENANCE_IN_RESPONSE_TO_DNA_DAMAGE": "Any process that modulates the frequency, rate or extent of telomere maintenance in response to DNA damage. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]", "GOBP_REGULATION_OF_TELOMERE_MAINTENANCE": "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. [GOC:mah]", "GOBP_REGULATION_OF_SYSTEM_PROCESS": "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. [GOC:jl]", "GOBP_REGULATION_OF_TERMINATION_OF_DNA_TEMPLATED_TRANSCRIPTION": "Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. [GOC:mlg, GOC:txnOH]", "GOBP_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING": "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "GOBP_REGULATION_OF_TESTOSTERONE_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process. [GOC:obol, GOC:yaf]", "GOBP_REGULATION_OF_TETRAPYRROLE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process. [GOC:mengo_curators, GOC:TermGenie]", "GOBP_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION": "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. [GOC:dph, GOC:tb, PMID:10358008]", "GOBP_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION_BY_CHEMICAL_SIGNAL": "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. [GOC:mtg_cardio, GOC:rl]", "GOBP_REGULATION_OF_THYROID_HORMONE_GENERATION": "Any process that modulates the frequency, rate or extent of thyroid hormone generation. [GOC:obol]", "GOBP_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS": "Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_REGULATION_OF_TOLERANCE_INDUCTION": "Any process that modulates the frequency, rate, or extent of tolerance induction. [GOC:add]", "GOBP_REGULATION_OF_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_REGULATION_OF_TOLL_LIKE_RECEPTOR_3_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_REGULATION_OF_TISSUE_REMODELING": "Any process that modulates the frequency, rate, or extent of tissue remodeling. [GOC:add]", "GOBP_REGULATION_OF_TOLL_LIKE_RECEPTOR_7_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_REGULATION_OF_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_REGULATION_OF_TOOTH_MINERALIZATION": "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_TOLL_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the Tl signaling pathway. [GOC:go_curators]", "GOBP_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_REGULATION_OF_TORC2_SIGNALING": "Any process that modulates the frequency, rate or extent of TORC2 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:24247430]", "GOBP_REGULATION_OF_TRANSCRIPTION_BY_GLUCOSE": "Any process involving glucose that modulates the frequency, rate or extent or transcription. [GOC:go_curators]", "GOBP_REGULATION_OF_TRANSCRIPTION_OF_NUCLEOLAR_LARGE_RRNA_BY_RNA_POLYMERASE_I": "Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I. [GOC:sart, GOC:TermGenie]", "GOBP_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_I": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I. [GOC:go_curators]", "GOBP_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_III": "Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III. [GOC:go_curators]", "GOBP_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING": "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. [GOC:obol]", "GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY": "Any process that modulates the ability of the translational apparatus to interpret the genetic code. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_TRANSLATIONAL_ELONGATION": "Any process that modulates the frequency, rate, extent or accuracy of translational elongation. [GOC:go_curators]", "GOBP_REGULATION_OF_TRANSLATIONAL_INITIATION_BY_EIF2_ALPHA_PHOSPHORYLATION": "", "GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [GOC:ai]", "GOBP_REGULATION_OF_TRANSLATIONAL_INITIATION": "Any process that modulates the frequency, rate or extent of translational initiation. [GOC:go_curators]", "GOBP_REGULATION_OF_TRANSLATION": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:isa_complete]", "GOBP_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS": "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. [GOC:jl]", "GOBP_REGULATION_OF_TRANSLATIONAL_TERMINATION": "Any process that modulates the frequency, rate or extent of translational termination. [GOC:go_curators]", "GOBP_REGULATION_OF_TRANSLATION_AT_SYNAPSE": "Any process that regulates translation occurring at the synapse. [PMID:20427644]", "GOBP_REGULATION_OF_TRANSLATION_AT_POSTSYNAPSE": "", "GOBP_REGULATION_OF_TRANSLATION_INITIATION_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "", "GOBP_REGULATION_OF_TRANSLATION_AT_SYNAPSE_MODULATING_SYNAPTIC_TRANSMISSION": "", "GOBP_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]", "GOBP_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS": "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:jl]", "GOBP_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE": "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. [GOC:ai]", "GOBP_REGULATION_OF_TRANSPORTER_ACTIVITY": "", "GOBP_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS": "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. [GOC:BHF, GOC:tb]", "GOBP_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. [GOC:rn, GOC:tb]", "GOBP_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_TRANSMEMBRANE_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. [GOC:mah]", "GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. [GOC:dph, GOC:sl, GOC:tb]", "GOBP_REGULATION_OF_TRANS_SYNAPTIC_SIGNALING": "Any process that modulates the frequency, rate or extent of trans-synaptic signaling. [GOC:dos]", "GOBP_REGULATION_OF_TUBE_SIZE": "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes. [PMID:10887083]", "GOBP_REGULATION_OF_TRANSPORT": "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate, or extent of a type 2 immune response. [GOC:add]", "GOBP_REGULATION_OF_TYPE_B_PANCREATIC_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. [GOC:dph]", "GOBP_REGULATION_OF_TYPE_B_PANCREATIC_CELL_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of pancreatic B cell development. [GOC:obol, GOC:yaf]", "GOBP_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY": "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]", "GOBP_REGULATION_OF_T_CELL_ACTIVATION_VIA_T_CELL_RECEPTOR_CONTACT_WITH_ANTIGEN_BOUND_TO_MHC_MOLECULE_ON_ANTIGEN_PRESENTING_CELL": "Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. [GOC:obol]", "GOBP_REGULATION_OF_T_CELL_CHEMOTAXIS": "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS": "Any process that modulates the occurrence or rate of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_REGULATION_OF_T_CELL_EXTRAVASATION": "Any process that modulates the frequency, rate or extent of T cell extravasation. [GOC:mah]", "GOBP_REGULATION_OF_T_CELL_ACTIVATION": "Any process that modulates the frequency, rate or extent of T cell activation. [GOC:ai]", "GOBP_REGULATION_OF_T_CELL_COSTIMULATION": "Any process that modulates the frequency, rate or extent of T cell costimulation. [GOC:obol]", "GOBP_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS": "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. [GOC:add, GOC:mah]", "GOBP_REGULATION_OF_T_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL": "", "GOBP_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY": "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149]", "GOBP_REGULATION_OF_T_CELL_MIGRATION": "Any process that modulates the frequency, rate or extent of T cell migration. [GOC:mah]", "GOBP_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY": "Any process that modulates the frequency, rate, or extent of T cell mediated immunity. [GOC:add]", "GOBP_REGULATION_OF_T_CIRCLE_FORMATION": "Any process that modulates the frequency, rate or extent of t-circle formation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]", "GOBP_REGULATION_OF_T_CELL_PROLIFERATION": "Any process that modulates the frequency, rate or extent of T cell proliferation. [GOC:jl]", "GOBP_REGULATION_OF_T_HELPER_17_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]", "GOBP_REGULATION_OF_T_HELPER_17_TYPE_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_T_HELPER_17_CELL_LINEAGE_COMMITMENT": "Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_T_HELPER_1_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE": "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]", "GOBP_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of T-helper cell differentiation. [GOC:go_curators]", "GOBP_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882]", "GOBP_REGULATION_OF_UBIQUITIN_PROTEIN_TRANSFERASE_ACTIVITY": "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity. [GOC:ai, GOC:tb]", "GOBP_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS": "Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process. [GO:0006636]", "GOBP_REGULATION_OF_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process. [GOC:BHF]", "GOBP_REGULATION_OF_URINE_VOLUME": "Any process that modulates the amount of urine excreted from the body over a unit of time. [GOC:mtg_25march11, GOC:yaf]", "GOBP_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_DEDIFFERENTIATION": "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]", "GOBP_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]", "GOBP_REGULATION_OF_VACUOLE_ORGANIZATION": "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. [GOC:jl, GOC:mah]", "GOBP_REGULATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CONTRACTION": "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction. [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl]", "GOBP_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. [GOC:dgh]", "GOBP_REGULATION_OF_VASCULAR_WOUND_HEALING": "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:dph]", "GOBP_REGULATION_OF_VASCULAR_PERMEABILITY": "Any process that modulates the extent to which blood vessels can be pervaded by fluid. [GOC:jl]", "GOBP_REGULATION_OF_VASCULOGENESIS": "Any process that modulates the frequency, rate or extent of vasculogenesis. [GOC:obol]", "GOBP_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_MEMBRANE_DEPOLARIZATION": "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION": "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb]", "GOBP_REGULATION_OF_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE": "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT": "Any process that modulates the frequency, rate or extent of vasculature development. [GOC:TermGenie]", "GOBP_REGULATION_OF_VASOCONSTRICTION": "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. [GOC:jl]", "GOBP_REGULATION_OF_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING": "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid. [GOC:tb]", "GOBP_REGULATION_OF_VESICLE_FUSION": "Any process that modulates the frequency, rate or extent of vesicle fusion. [GOC:mah]", "GOBP_REGULATION_OF_VESICLE_SIZE": "Any process that modulates the size of a vesicle. [GOC:pm, PMID:20007772]", "GOBP_REGULATION_OF_VIRAL_GENOME_REPLICATION": "Any process that modulates the frequency, rate or extent of viral genome replication. [GOC:ai]", "GOBP_REGULATION_OF_VIRAL_TRANSCRIPTION": "Any process that modulates the frequency, rate or extent of the transcription of the viral genome. [GOC:ai]", "GOBP_REGULATION_OF_VIRAL_PROCESS": "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts. [GOC:go_curators, GOC:tb]", "GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT": "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. [GOC:dph, GOC:tb]", "GOBP_REGULATION_OF_VITAMIN_D_BIOSYNTHETIC_PROCESS": "Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]", "GOBP_REGULATION_OF_VITAMIN_METABOLIC_PROCESS": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:mah]", "GOBP_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY": "Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie]", "GOBP_REGULATION_OF_VITAMIN_D_RECEPTOR_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity. [GOC:BHF, GOC:mah]", "GOBP_REGULATION_OF_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY": "", "GOBP_REGULATION_OF_WNT_PROTEIN_SECRETION": "Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell. [GOC:bf, PMID:19223472]", "GOBP_REGULATION_OF_XENOPHAGY": "Any process that modulates the frequency, rate or extent of xenophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041]", "GOBP_REGULATION_OF_XENOBIOTIC_DETOXIFICATION_BY_TRANSMEMBRANE_EXPORT_ACROSS_THE_PLASMA_MEMBRANE": "", "GOBP_REGULATION_OF_WOUND_HEALING": "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:BHF, GOC:dph]", "GOBP_REGULATORY_NCRNA_MEDIATED_HETEROCHROMATIN_FORMATION": "A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginning of trancription. [PMID:19239886, PMID:21420348]", "GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY": "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. [GOC:dph, GOC:mah, GOC:tb]", "GOBP_REGULATION_OF_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS": "Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]", "GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY": "Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. [GOC:BHF]", "GOBP_REGULATION_PROTEIN_CATABOLIC_PROCESS_AT_SYNAPSE": "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. [PMID:23083742]", "GOBP_REGULATORY_NCRNA_PROCESSING": "A process leading to the generation of a functional regulatory non-coding RNA. [GOC:mah, PMID:15196465, PMID:19239886]", "GOBP_RELAXATION_OF_CARDIAC_MUSCLE": "The process in which the extent of cardiac muscle contraction is reduced. [GOC:ecd]", "GOBP_REGULATORY_T_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types. [ISBN:0781735149]", "GOBP_REGULATORY_NCRNA_MEDIATED_GENE_SILENCING": "A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. [PMID:15020054]", "GOBP_RELAXATION_OF_MUSCLE": "A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. [GOC:BHF, GOC:rl, PMID:19996365]", "GOBP_RELAXATION_OF_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE": "A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:dph, GOC:rph, GOC:TermGenie, PMID:15867178, PMID:19996365, PMID:27389411]", "GOBP_RELAXATION_OF_SMOOTH_MUSCLE": "A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:jl]", "GOBP_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_ENDOPLASMIC_RETICULUM": "The directed movement of calcium ion from endoplasmic reticulum to cytosol. [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920]", "GOBP_RENAL_ALBUMIN_ABSORPTION": "A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. [GOC:yaf, PMID:18431508]", "GOBP_RENAL_ABSORPTION": "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). [GOC:dph, GOC:mah, GOC:yaf]", "GOBP_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA": "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217]", "GOBP_RENAL_CONTROL_OF_PERIPHERAL_VASCULAR_RESISTANCE_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE": "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature. [GOC:mtg_cardio]", "GOBP_RENAL_PROTEIN_ABSORPTION": "A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). [GOC:yaf, PMID:18431508]", "GOBP_RENAL_RESPONSE_TO_BLOOD_FLOW_INVOLVED_IN_CIRCULATORY_RENIN_ANGIOTENSIN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE": "The physiological response of the kidneys to a decrease in blood flow. [GOC:dph]", "GOBP_RENAL_FILTRATION": "A renal system process in which fluid circulating through the body is filtered through a barrier system. [GOC:pr, GOC:sart]", "GOBP_RENAL_SODIUM_EXCRETION": "The elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. [GOC:mtg_25march11, GOC:yaf, PMID:25287933]", "GOBP_RENAL_SODIUM_ION_TRANSPORT": "The directed movement of sodium ions (Na+) by the renal system. [GOC:mtg_cardio]", "GOBP_RENAL_SODIUM_ION_ABSORPTION": "", "GOBP_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME": "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. [GOC:dph, GOC:tb, ISBN:0721643949]", "GOBP_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE": "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, GOC:tb]", "GOBP_RENAL_SYSTEM_VASCULATURE_MORPHOGENESIS": "The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form. [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]", "GOBP_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT": "The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]", "GOBP_RENAL_SYSTEM_PROCESS": "An organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]", "GOBP_RENAL_TUBULAR_SECRETION": "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion]", "GOBP_RENAL_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. [GOC:mtg_kidney_jan10, GOC:yaf, PMID:6996269]", "GOBP_RENAL_TUBULE_DEVELOPMENT": "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. [GOC:dph, GOC:mtg_kidney_jan10]", "GOBP_RENAL_VESICLE_DEVELOPMENT": "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10]", "GOBP_RENAL_VESICLE_FORMATION": "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10]", "GOBP_RENAL_WATER_ABSORPTION": "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:dph, GOC:mah]", "GOBP_RENAL_WATER_HOMEOSTASIS": "Renal process involved in the maintenance of an internal steady state of water in the body. [GOC:mtg_cardio]", "GOBP_RENAL_WATER_TRANSPORT": "The directed movement of water (H2O) by the renal system. [GOC:mtg_cardio]", "GOBP_REPLICATION_BORN_DOUBLE_STRAND_BREAK_REPAIR_VIA_SISTER_CHROMATID_EXCHANGE": "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks. [GOC:rb, PMID:12820977, PMID:16888651]", "GOBP_REPLACEMENT_OSSIFICATION": "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. [GO_REF:0000034]", "GOBP_REPLICATIVE_SENESCENCE": "The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening. [PMID:17014937, PMID:23061726]", "GOBP_REPRODUCTIVE_BEHAVIOR": "The specific behavior of an organism that is associated with reproduction. [GOC:jl, GOC:pr]", "GOBP_RESOLUTION_OF_DNA_RECOMBINATION_INTERMEDIATES": "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged. [GOC:elh, GOC:mah, GOC:vw]", "GOBP_RESCUE_OF_STALLED_RIBOSOME": "A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex. [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543]", "GOBP_RESOLUTION_OF_MEIOTIC_RECOMBINATION_INTERMEDIATES": "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged. [GOC:elh, PMID:11733053]", "GOBP_RESPIRATORY_BURST_INVOLVED_IN_DEFENSE_RESPONSE": "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:add, ISBN:0781735149, PMID:12789499]", "GOBP_RESPIRATORY_BURST": "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [ISBN:0198506732]", "GOBP_RESPIRATORY_BURST_INVOLVED_IN_INFLAMMATORY_RESPONSE": "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels. [GOC:add, ISBN:0781735149]", "GOBP_RESPIRATORY_CHAIN_COMPLEX_III_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents. [GOC:jl, PMID:12833641, PMID:20116362]", "GOBP_REPRODUCTIVE_SYSTEM_DEVELOPMENT": "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. [GOC:dph]", "GOBP_RESPIRATORY_GASEOUS_EXCHANGE_BY_RESPIRATORY_SYSTEM": "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. [ISBN:0198506732]", "GOBP_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. [GOC:jl, PMID:32311046]", "GOBP_REPRODUCTIVE_PROCESS": "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. [GOC:dph, GOC:isa_complete]", "GOBP_RESPONSE_TO_2_3_7_8_TETRACHLORODIBENZODIOXINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23196670]", "GOBP_RESPIRATORY_SYSTEM_PROCESS": "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. [GOC:dph, GOC:mtg_cardio, GOC:tb]", "GOBP_RESPIRATORY_SYSTEM_DEVELOPMENT": "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. [GOC:dph]", "GOBP_RESPONSE_TO_ACIDIC_PH": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:go_curators, GOC:tb, Wikipedia:PH]", "GOBP_RESPONSE_TO_ACETYLCHOLINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497]", "GOBP_RESPONSE_TO_ACTINOMYCIN_D": "", "GOBP_RESPONSE_TO_ACID_CHEMICAL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. [GOC:go_curators, GOC:rn]", "GOBP_RESPONSE_TO_ACTIVITY": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. [GOC:mtg_muscle]", "GOBP_RESPONSE_TO_ALDOSTERONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17644563]", "GOBP_RESPONSE_TO_ABIOTIC_STIMULUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. [GOC:hb]", "GOBP_RESPONSE_TO_ALKALOID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. [GOC:jl]", "GOBP_RESPONSE_TO_AMINO_ACID_STARVATION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. [PMID:7765311]", "GOBP_RESPONSE_TO_AMINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. [GOC:ef]", "GOBP_RESPONSE_TO_AMMONIUM_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23509267]", "GOBP_RESPONSE_TO_ALCOHOL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. [GOC:pr, PMID:24014527]", "GOBP_RESPONSE_TO_AMPHETAMINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef]", "GOBP_RESPONSE_TO_AMYLOID_BETA": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]", "GOBP_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:hjd, ISBN:0721662544]", "GOBP_RESPONSE_TO_ANGIOTENSIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. [PMID:22982863]", "GOBP_RESPONSE_TO_ANTIBIOTIC": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. [GOC:ai, GOC:ef]", "GOBP_RESPONSE_TO_ATP": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_BACTERIAL_LIPOPROTEIN": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus. [GOC:add, PMID:12077222]", "GOBP_RESPONSE_TO_AUDITORY_STIMULUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]", "GOBP_RESPONSE_TO_BILE_ACID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]", "GOBP_RESPONSE_TO_AXON_INJURY": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]", "GOBP_RESPONSE_TO_BLUE_LIGHT": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. [GOC:ai, GOC:mtg_far_red]", "GOBP_RESPONSE_TO_CAFFEINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. [GOC:ef, GOC:mah]", "GOBP_RESPONSE_TO_BACTERIUM": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb]", "GOBP_RESPONSE_TO_CADMIUM_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. [GOC:ai]", "GOBP_RESPONSE_TO_BMP": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. [GOC:mah, GOC:yaf]", "GOBP_RESPONSE_TO_CALCIUM_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:ai]", "GOBP_RESPONSE_TO_CAMP": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:ai]", "GOBP_RESPONSE_TO_CATECHOLAMINE": "", "GOBP_RESPONSE_TO_CGMP": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_CELL_CYCLE_CHECKPOINT_SIGNALING": "A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling. [GOC:mtg_cell_cycle]", "GOBP_RESPONSE_TO_CARBOHYDRATE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. [GOC:jl]", "GOBP_RESPONSE_TO_COBALT_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion (Co2+) stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_COCAINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:ef, GOC:jl]", "GOBP_RESPONSE_TO_CHEMOKINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. [PMID:11113082]", "GOBP_RESPONSE_TO_COLD": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:lr]", "GOBP_RESPONSE_TO_CORTICOSTERONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. [PMID:15240347]", "GOBP_RESPONSE_TO_CORTISOL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions. [ISBN:0721662544, PMID:11276391]", "GOBP_RESPONSE_TO_CORTICOTROPIN_RELEASING_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone]", "GOBP_RESPONSE_TO_COPPER_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. [GOC:ai]", "GOBP_RESPONSE_TO_CYCLOHEXIMIDE": "", "GOBP_RESPONSE_TO_CORTICOSTEROID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. [GOC:mah, PMID:11027914]", "GOBP_RESPONSE_TO_CYTOKINE": "", "GOBP_RESPONSE_TO_DEXAMETHASONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. [GOC:mah, GOC:yaf]", "GOBP_RESPONSE_TO_DSRNA": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. [GOC:jl]", "GOBP_RESPONSE_TO_DISACCHARIDE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus. [GOC:sart]", "GOBP_RESPONSE_TO_DIACYL_BACTERIAL_LIPOPEPTIDE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]", "GOBP_RESPONSE_TO_EPINEPHRINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. [GOC:BHF, GOC:mah]", "GOBP_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. [GOC:BHF, GOC:mah]", "GOBP_RESPONSE_TO_ELECTRICAL_STIMULUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. [GOC:ai]", "GOBP_RESPONSE_TO_DIETARY_EXCESS": "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. [GOC:pg, GOC:pr, PMID:12161655]", "GOBP_RESPONSE_TO_ERYTHROPOIETIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis. [GOC:yaf]", "GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:cjm, GOC:mah]", "GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. [GOC:sm]", "GOBP_RESPONSE_TO_ESTRADIOL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]", "GOBP_RESPONSE_TO_ETHER": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. [GOC:go_curators]", "GOBP_RESPONSE_TO_ESTROGEN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:jl, ISBN:0198506732]", "GOBP_RESPONSE_TO_ETHANOL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]", "GOBP_RESPONSE_TO_FOLIC_ACID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. [GOC:ai]", "GOBP_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_FLUID_SHEAR_STRESS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. [GOC:sl]", "GOBP_RESPONSE_TO_FATTY_ACID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:lp]", "GOBP_RESPONSE_TO_FORSKOLIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:15937517]", "GOBP_RESPONSE_TO_FOOD": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. [GOC:add, ISBN:0721601464]", "GOBP_RESPONSE_TO_FRUCTOSE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. [GOC:jl]", "GOBP_RESPONSE_TO_FUNGICIDE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. [GOC:dph]", "GOBP_RESPONSE_TO_GLUCAGON": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_FUNGUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. [GOC:hb]", "GOBP_RESPONSE_TO_GONADOTROPIN_RELEASING_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. [GOC:yaf, PMID:15976007]", "GOBP_RESPONSE_TO_GLYCOPROTEIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:14597422]", "GOBP_RESPONSE_TO_GONADOTROPIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. [GOC:BHF, GOC:vk]", "GOBP_RESPONSE_TO_GAMMA_RADIATION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:tair_curators]", "GOBP_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium. [PMID:23664307]", "GOBP_RESPONSE_TO_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus. [GOC:pr]", "GOBP_RESPONSE_TO_GRAVITY": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. [GOC:hb]", "GOBP_RESPONSE_TO_HEPARIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus. [GOC:mah, GOC:yaf]", "GOBP_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. [GOC:bf]", "GOBP_RESPONSE_TO_HEAT": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:lr]", "GOBP_RESPONSE_TO_GROWTH_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. [GOC:BHF, GOC:dph]", "GOBP_RESPONSE_TO_HISTAMINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. [GOC:BHF, GOC:mah, GOC:vk]", "GOBP_RESPONSE_TO_HUMAN_CHORIONIC_GONADOTROPIN": "", "GOBP_RESPONSE_TO_HYDROPEROXIDE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. [GOC:mah]", "GOBP_RESPONSE_TO_HYDROGEN_PEROXIDE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [GOC:jl]", "GOBP_RESPONSE_TO_GROWTH_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. [GOC:BHF, GOC:mah]", "GOBP_RESPONSE_TO_HYDROSTATIC_PRESSURE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. [Wikipedia:Hydrostatic_pressure]", "GOBP_RESPONSE_TO_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:jl]", "GOBP_RESPONSE_TO_HYDROXYUREA": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_IMMOBILIZATION_STRESS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. [GOC:bf, PMID:17683801, PMID:19893991]", "GOBP_RESPONSE_TO_HYPEROXIA": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. [GOC:kmv]", "GOBP_RESPONSE_TO_INCREASED_OXYGEN_LEVELS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. [GOC:al]", "GOBP_RESPONSE_TO_INACTIVITY": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. [GOC:mtg_muscle]", "GOBP_RESPONSE_TO_INDOLE_3_METHANOL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus. [GOC:mah, GOC:yaf]", "GOBP_RESPONSE_TO_INORGANIC_SUBSTANCE": "", "GOBP_RESPONSE_TO_INSECTICIDE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. [GOC:curators]", "GOBP_RESPONSE_TO_INTERFERON_ALPHA": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. [GOC:sl, PMID:11356686]", "GOBP_RESPONSE_TO_INTERFERON_BETA": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. [GOC:sl, PMID:9561374]", "GOBP_RESPONSE_TO_INSULIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]", "GOBP_RESPONSE_TO_INTERLEUKIN_15": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_INTERLEUKIN_12": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_INTERLEUKIN_13": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. [GOC:sjw, PMID:20100461]", "GOBP_RESPONSE_TO_INTERLEUKIN_17": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus. [GOC:pr]", "GOBP_RESPONSE_TO_INTERLEUKIN_18": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_INTERLEUKIN_2": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_INTERLEUKIN_1": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:BHF, GOC:mah]", "GOBP_RESPONSE_TO_INTERLEUKIN_3": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus. [GOC:yaf]", "GOBP_RESPONSE_TO_INTERLEUKIN_9": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus. [GOC:mah, GOC:yaf]", "GOBP_RESPONSE_TO_INTERLEUKIN_7": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus. [GOC:BHF, GOC:mah]", "GOBP_RESPONSE_TO_INTERLEUKIN_4": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_INTERLEUKIN_6": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_IRON_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. [GOC:sm]", "GOBP_RESPONSE_TO_IRON_II_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. [GOC:sm]", "GOBP_RESPONSE_TO_ISOQUINOLINE_ALKALOID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. [GOC:ef]", "GOBP_RESPONSE_TO_ISCHEMIA": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. [GOC:hjd]", "GOBP_RESPONSE_TO_IONIZING_RADIATION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. [PMID:12509526]", "GOBP_RESPONSE_TO_LECTIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. [PMID:25996210, PMID:26306444]", "GOBP_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. [GOC:ecd]", "GOBP_RESPONSE_TO_KETONE": "A response that results in a state of tolerance to ketone. [GOC:mengo_curators, PMID:23356676]", "GOBP_RESPONSE_TO_LEPTIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. [GOC:yaf]", "GOBP_RESPONSE_TO_LEAD_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. [GOC:tair_curators, PMID:16461380]", "GOBP_RESPONSE_TO_LIGHT_INTENSITY": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus. [GOC:go_curators]", "GOBP_RESPONSE_TO_LEUKEMIA_INHIBITORY_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]", "GOBP_RESPONSE_TO_LIPOTEICHOIC_ACID": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. [GOC:add, PMID:14665680, PMID:16020688]", "GOBP_RESPONSE_TO_LITHIUM_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. [GOC:tb]", "GOBP_RESPONSE_TO_LUTEINIZING_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. [GOC:BHF, GOC:vk]", "GOBP_RESPONSE_TO_L_ASCORBIC_ACID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_L_LEUCINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus. [GOC:mlg]", "GOBP_RESPONSE_TO_L_GLUTAMATE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus. [GOC:TermGenie, PMID:23574009]", "GOBP_RESPONSE_TO_LIGHT_STIMULUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. [GOC:go_curators, ISBN:0582227089]", "GOBP_RESPONSE_TO_L_PHENYLALANINE_DERIVATIVE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12112407]", "GOBP_RESPONSE_TO_LIPID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_MACROPHAGE_COLONY_STIMULATING_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. [GOC:yaf, PMID:14687666]", "GOBP_RESPONSE_TO_MAGNESIUM_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_MANGANESE_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. [GOC:sm]", "GOBP_RESPONSE_TO_MERCURY_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. [GOC:ai]", "GOBP_RESPONSE_TO_METHIONINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17716000]", "GOBP_RESPONSE_TO_MISFOLDED_PROTEIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. [GOC:go_curators]", "GOBP_RESPONSE_TO_MECHANICAL_STIMULUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:hb]", "GOBP_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION": "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. [GOC:dos]", "GOBP_RESPONSE_TO_MINERALOCORTICOID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. [GOC:ai, PMID:9884123]", "GOBP_RESPONSE_TO_MOLECULE_OF_FUNGAL_ORIGIN": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. [GOC:rl, GOC:sm]", "GOBP_RESPONSE_TO_MURAMYL_DIPEPTIDE": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. [GOC:add]", "GOBP_RESPONSE_TO_MUSCLE_INACTIVITY": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. [GOC:mtg_muscle]", "GOBP_RESPONSE_TO_MUSCLE_ACTIVITY": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. [GOC:mtg_muscle]", "GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. [GOC:rl, GOC:sm]", "GOBP_RESPONSE_TO_METAL_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. [GOC:sm]", "GOBP_RESPONSE_TO_MUSCLE_STRETCH": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. [GOC:BHF, GOC:vk, PMID:14583192]", "GOBP_RESPONSE_TO_NEMATODE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. [GOC:hb]", "GOBP_RESPONSE_TO_NERVE_GROWTH_FACTOR": "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. [PMID:22399805]", "GOBP_RESPONSE_TO_NICOTINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]", "GOBP_RESPONSE_TO_NITRIC_OXIDE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. [GOC:mah, GOC:yaf]", "GOBP_RESPONSE_TO_NITROSATIVE_STRESS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. [PMID:15925705]", "GOBP_RESPONSE_TO_ODORANT": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell. [PMID:11268007]", "GOBP_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND": "", "GOBP_RESPONSE_TO_NUTRIENT": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators]", "GOBP_RESPONSE_TO_NITROGEN_COMPOUND": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. [GOC:pr, GOC:TermGenie]", "GOBP_RESPONSE_TO_ORGANOPHOSPHORUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. [ISBN:0721662544]", "GOBP_RESPONSE_TO_OSMOTIC_STRESS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:jl]", "GOBP_RESPONSE_TO_NUTRIENT_LEVELS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah]", "GOBP_RESPONSE_TO_OXYGEN_GLUCOSE_DEPRIVATION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. [GOC:sl, PMID:21525936]", "GOBP_RESPONSE_TO_OXYGEN_RADICAL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. [GOC:krc, ISBN:0124325653]", "GOBP_RESPONSE_TO_OXIDATIVE_STRESS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]", "GOBP_RESPONSE_TO_OZONE": "", "GOBP_RESPONSE_TO_PARATHYROID_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. [GOC:mah, GOC:yaf]", "GOBP_RESPONSE_TO_PAIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]", "GOBP_RESPONSE_TO_OXYGEN_LEVELS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. [GOC:BHF, GOC:mah]", "GOBP_RESPONSE_TO_PEPTIDOGLYCAN": "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. [GOC:add, ISBN:0721601464]", "GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. [GOC:pr, GOC:TermGenie]", "GOBP_RESPONSE_TO_PHENYLPROPANOID": "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. [GOC:tb]", "GOBP_RESPONSE_TO_PEPTIDE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. [GOC:pr, GOC:TermGenie]", "GOBP_RESPONSE_TO_PHORBOL_13_ACETATE_12_MYRISTATE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:2200903]", "GOBP_RESPONSE_TO_PHEROMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. [GOC:jl]", "GOBP_RESPONSE_TO_PH": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. [GOC:jl, Wikipedia:PH]", "GOBP_RESPONSE_TO_PEPTIDE_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]", "GOBP_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. [GOC:yaf]", "GOBP_RESPONSE_TO_POTASSIUM_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. [GOC:yaf]", "GOBP_RESPONSE_TO_PROGESTERONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_PROSTAGLANDIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. [GOC:BHF, GOC:vk]", "GOBP_RESPONSE_TO_PROSTAGLANDIN_E": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. [GOC:BHF, GOC:vk]", "GOBP_RESPONSE_TO_PROSTAGLANDIN_D": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_PROTOZOAN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. [GOC:ai]", "GOBP_RESPONSE_TO_RAPAMYCIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus. [GOC:TermGenie]", "GOBP_RESPONSE_TO_PURINE_CONTAINING_COMPOUND": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. [GOC:ef]", "GOBP_RESPONSE_TO_REDOX_STATE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. [GOC:mah, PMID:15131240, PMID:16987039]", "GOBP_RESPONSE_TO_RADIATION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. [GOC:jl, Wikipedia:Electromagnetic_radiation]", "GOBP_RESPONSE_TO_SALT": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. [GOC:mls, GOC:TermGenie, PMID:16666921]", "GOBP_RESPONSE_TO_SALT_STRESS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:jl]", "GOBP_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:krc]", "GOBP_RESPONSE_TO_SELENIUM_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. [GOC:mg]", "GOBP_RESPONSE_TO_RETINOIC_ACID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_SODIUM_ARSENITE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18674524]", "GOBP_RESPONSE_TO_SORBITOL": "", "GOBP_RESPONSE_TO_SODIUM_PHOSPHATE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24625659]", "GOBP_RESPONSE_TO_STARVATION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. [GOC:go_curators]", "GOBP_RESPONSE_TO_STEROL_DEPLETION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:bf, ISBN:0198506732]", "GOBP_RESPONSE_TO_STILBENOID": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. [GOC:yaf, Wikipedia:Stilbenoid]", "GOBP_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]", "GOBP_RESPONSE_TO_SYMBIONT": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:hb, ISBN:0198506732]", "GOBP_RESPONSE_TO_STEROL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. [GOC:bf]", "GOBP_RESPONSE_TO_STEROID_HORMONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. [GOC:go_curators]", "GOBP_RESPONSE_TO_THYROGLOBULIN_TRIIODOTHYRONINE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:7531505]", "GOBP_RESPONSE_TO_THYROID_HORMONE": "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. [GOC:sjw, PMID:9916872]", "GOBP_RESPONSE_TO_TESTOSTERONE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_TEMPERATURE_STIMULUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. [GOC:hb]", "GOBP_RESPONSE_TO_THYROXINE": "", "GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. [GOC:bf]", "GOBP_RESPONSE_TO_TUMOR_CELL": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]", "GOBP_RESPONSE_TO_TYPE_III_INTERFERON": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]", "GOBP_RESPONSE_TO_TOXIC_SUBSTANCE": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr]", "GOBP_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]", "GOBP_RESPONSE_TO_TYPE_I_INTERFERON": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]", "GOBP_RESPONSE_TO_TYPE_II_INTERFERON": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. [GOC:add, ISBN:0126896631, PMID:15546383]", "GOBP_RESPONSE_TO_UV_A": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. [GOC:BHF, GOC:mah]", "GOBP_RESPONSE_TO_UV": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:hb]", "GOBP_RESPONSE_TO_UV_B": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. [GOC:tb]", "GOBP_RESPONSE_TO_VASOPRESSIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22811487]", "GOBP_RESPONSE_TO_UV_C": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. [GOC:tb]", "GOBP_RESPONSE_TO_VITAMIN_A": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_VITAMIN": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_VITAMIN_E": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_VITAMIN_D": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_VITAMIN_K": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus. [GOC:sl]", "GOBP_RESPONSE_TO_WATER": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. [GOC:jl]", "GOBP_RESPONSE_TO_VIRUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb]", "GOBP_RESPONSE_TO_WATER_DEPRIVATION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. [GOC:lr]", "GOBP_RESPONSE_TO_X_RAY": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). [GOC:sm, Wikipedia:X-ray]", "GOBP_RESPONSE_TO_YEAST": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. [PMID:14707091]", "GOBP_RESPONSE_TO_ZINC_ION_STARVATION": "", "GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]", "GOBP_RETICULOPHAGY": "The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]", "GOBP_RETINAL_BIPOLAR_NEURON_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina. [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]", "GOBP_RESPONSE_TO_ZINC_ION": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. [GOC:sm]", "GOBP_RESPONSE_TO_WOUNDING": "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. [GOC:go_curators]", "GOBP_RETINAL_BLOOD_VESSEL_MORPHOGENESIS": "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. [GOC:BHF, GOC:dph]", "GOBP_RETINAL_CELL_APOPTOTIC_PROCESS": "", "GOBP_RETINAL_CONE_CELL_DEVELOPMENT": "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. [ISBN:0198506732]", "GOBP_RETINAL_CELL_PROGRAMMED_CELL_DEATH": "Programmed cell death that occurs in the developing retina. [GOC:bf]", "GOBP_RETINAL_CONE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. [GOC:go_curators]", "GOBP_RETINAL_GANGLION_CELL_AXON_GUIDANCE": "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:ejs]", "GOBP_RETINAL_PIGMENT_EPITHELIUM_DEVELOPMENT": "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_RETINAL_METABOLIC_PROCESS": "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. [ISBN:0198506732]", "GOBP_RETINAL_ROD_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. [GOC:dph]", "GOBP_RETINAL_ROD_CELL_DEVELOPMENT": "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. [ISBN:0198506732]", "GOBP_RETINA_HOMEOSTASIS": "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]", "GOBP_RETINA_LAYER_FORMATION": "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266]", "GOBP_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE": "The process in which the anatomical structure of the retina is generated and organized. [GOC:bf, GOC:dph, GOC:mtg_sensu]", "GOBP_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE": "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. [GOC:bf, GOC:dph, ISBN:0815340729]", "GOBP_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE": "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. [GOC:BHF, GOC:dph]", "GOBP_RETINA_VASCULATURE_MORPHOGENESIS_IN_CAMERA_TYPE_EYE": "The process in which the vasculature of the retina is generated and organized. [GOC:BHF, GOC:dph]", "GOBP_RETINOIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, PMID:12570742]", "GOBP_RETROGRADE_AXONAL_TRANSPORT": "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons. [ISBN:0815316194]", "GOBP_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY": "A nuclear receptor-mediated signaling pathway initiated by a retinoic acid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription. [GOC:dgh]", "GOBP_RETINOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, PMID:1924551]", "GOBP_RETROGRADE_NEURONAL_DENSE_CORE_VESICLE_TRANSPORT": "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body. [GOC:kmv, PMID:23358451, PMID:24762653]", "GOBP_RETROGRADE_TRANS_SYNAPTIC_SIGNALING": "Cell-cell signaling from post to pre-synapse, across the synaptic cleft. [GOC:dos]", "GOBP_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI": "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. [GOC:jl, PMID:10873832, PMID:16936697]", "GOBP_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI": "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. [ISBN:0716731363]", "GOBP_RETROGRADE_TRANS_SYNAPTIC_SIGNALING_BY_LIPID": "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. [GOC:dos]", "GOBP_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ENDOPLASMIC_RETICULUM": "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. [ISBN:0716731363, PMID:16510524]", "GOBP_REVERSE_CHOLESTEROL_TRANSPORT": "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. [GOC:ecd, PMID:7751809]", "GOBP_RETROTRANSPOSON_SILENCING_BY_HETEROCHROMATIN_FORMATION": "", "GOBP_REVERSIBLE_DIFFERENTIATION": "A phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another. [GOC:curators]", "GOBP_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY": "", "GOBP_RHOMBOMERE_DEVELOPMENT": "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_RIBOFLAVIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). [GOC:jl, PMID:11153262, PMID:24764086]", "GOBP_RHYTHMIC_BEHAVIOR": "The specific behavior of an organism that recur with measured regularity. [GOC:jl, GOC:pr]", "GOBP_RHO_PROTEIN_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal. [GOC:bf]", "GOBP_RIBOFLAVIN_TRANSPORT": "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. [GOC:rn, PMID:16204239]", "GOBP_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION": "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. [GOC:mah]", "GOBP_RHYTHMIC_PROCESS": "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. [GOC:jid]", "GOBP_RIBONUCLEOSIDE_DIPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_RIBONUCLEOSIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:jl]", "GOBP_RIBONUCLEOSIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. [GOC:jl]", "GOBP_RIBONUCLEOSIDE_MONOPHOSPHATE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_RIBONUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS": "", "GOBP_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]", "GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. [GOC:isa_complete, GOC:mah]", "GOBP_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428]", "GOBP_RIBOSE_PHOSPHATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar. [GOC:ai]", "GOBP_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY": "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. [GOC:jl, PMID:30467428]", "GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl]", "GOBP_RIBOSE_PHOSPHATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar. [GOC:ai]", "GOBP_RIBOSOMAL_LARGE_SUBUNIT_EXPORT_FROM_NUCLEUS": "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. [GOC:mah]", "GOBP_RIBOSOMAL_SMALL_SUBUNIT_EXPORT_FROM_NUCLEUS": "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. [GOC:mah]", "GOBP_RIBOSOMAL_SUBUNIT_EXPORT_FROM_NUCLEUS": "", "GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl]", "GOBP_RIBOSOME_ASSEMBLY": "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. [GOC:ma, PMID:30467428]", "GOBP_RIBOSOME_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein. [GOC:dgf, PMID:23358411]", "GOBP_RIGHTING_REFLEX": "A reflex process in which an animal immediately tries to turn over after being placed in a supine position. [GOC:dph, PMID:8635460]", "GOBP_RIG_I_SIGNALING_PATHWAY": "The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines. [GOC:bf, PMID:17328678, PMID:19620789, PMID:21435580, PMID:25579795]", "GOBP_RISC_COMPLEX_ASSEMBLY": "The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing complement complex that mediates gene silencing by small RNA. [PMID:14512631, PMID:14744438, PMID:19239886, PMID:22233755, PMID:27184117]", "GOBP_RNA_3_URIDYLATION": "", "GOBP_RIBOSOME_DISASSEMBLY": "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. [GOC:mah, GOC:vk]", "GOBP_RNA_3_END_PROCESSING": "Any process involved in forming the mature 3' end of an RNA molecule. [GOC:mah]", "GOBP_RNA_CAPPING": "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts. [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673]", "GOBP_RNA_5_END_PROCESSING": "Any process involved in forming the mature 5' end of an RNA molecule. [GOC:krc]", "GOBP_RIBOSOME_BIOGENESIS": "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]", "GOBP_RNA_DECAPPING": "Cleavage of the 5'-cap of an RNA. [GOC:sp, PMID:25533955, PMID:31101919]", "GOBP_RNA_EXPORT_FROM_NUCLEUS": "The directed movement of RNA from the nucleus to the cytoplasm. [GOC:ma]", "GOBP_RNA_GUANINE_N7_METHYLATION": "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule. [GOC:BHF, GOC:rl]", "GOBP_RNA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. [ISBN:0198506732]", "GOBP_RNA_IMPORT_INTO_MITOCHONDRION": "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix. [GOC:ans, PMID:20691904]", "GOBP_RNA_LOCALIZATION": "A process in which RNA is transported to, or maintained in, a specific location. [GOC:ai]", "GOBP_RNA_POLYMERASE_I_PREINITIATION_COMPLEX_ASSEMBLY": "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which includes including UBF, SL1, RRN3 and TBP in human). The PIC engages RNA polymerase I on its DNA template strand and sparks polymerization of the first few RNA nucleotides. [GOC:txnOH, PMID:14969726]", "GOBP_RNA_METHYLATION": "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. [GOC:hjd, PMID:21823225]", "GOBP_RNA_MODIFICATION": "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. [GOC:go_curators, ISBN:1555811337]", "GOBP_RNA_POLYMERASE_II_PREINITIATION_COMPLEX_ASSEMBLY": "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA. [GOC:txnOH, PMID:15020047, PMID:31300188]", "GOBP_RNA_SECONDARY_STRUCTURE_UNWINDING": "", "GOBP_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION": "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. [GOC:krc, ISBN:0879695897]", "GOBP_RNA_STABILIZATION": "", "GOBP_RNA_SPLICING": "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. [GOC:krc, GOC:mah]", "GOBP_RNA_PROCESSING": "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. [GOC:mah]", "GOBP_RNA_TEMPLATED_DNA_BIOSYNTHETIC_PROCESS": "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. [GOC:mah, ISBN:0198506732]", "GOBP_RNA_SURVEILLANCE": "A process that identifies and degrades defective or aberrant RNAs. [GOC:dgf, GOC:krc, PMID:18644474]", "GOBP_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING": "The process in which the neural tube is divided into specific regions along the rostrocaudal axis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]", "GOBP_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS": "Splicing of RNA via a series of two transesterification reactions. [GOC:krc]", "GOBP_ROOF_OF_MOUTH_DEVELOPMENT": "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. [GOC:dph, ISBN:0721662544]", "GOBP_ROUNDABOUT_SIGNALING_PATHWAY": "The series of molecular signals initiated by a SLIT protein binding to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:signaling]", "GOBP_RRNA_3_END_PROCESSING": "Any process involved in forming the mature 3' end of an rRNA molecule. [GOC:mah]", "GOBP_RRNA_BASE_METHYLATION": "The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. [GOC:mah]", "GOBP_RRNA_5_END_PROCESSING": "Any process involved in forming the mature 5' end of an rRNA molecule. [GOC:krc]", "GOBP_RRNA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. [GOC:ai]", "GOBP_RRNA_METHYLATION": "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. [GOC:mah]", "GOBP_RRNA_MODIFICATION": "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. [GOC:curators]", "GOBP_RRNA_PSEUDOURIDINE_SYNTHESIS": "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule. [GOC:mah]", "GOBP_RUFFLE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. [GOC:yaf, PMID:12556481, Wikipedia:Membrane_ruffling]", "GOBP_RRNA_TRANSCRIPTION": "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. [GOC:jl, ISBN:0198506732]", "GOBP_RRNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. [ISBN:0198506732]", "GOBP_R_LOOP_PROCESSING": "A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability. [PMID:27252122, PMID:28790157, PMID:33986538]", "GOBP_RUFFLE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. [GOC:mah, PMID:10036235]", "GOBP_RRNA_PROCESSING": "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. [GOC:curators]", "GOBP_SALIVA_SECRETION": "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. [GOC:curators, UBERON:0001836]", "GOBP_SALIVARY_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. [GOC:jid, UBERON:0001044]", "GOBP_SARCOMERE_ORGANIZATION": "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:bf]", "GOBP_SATELLITE_CELL_ACTIVATION_INVOLVED_IN_SKELETAL_MUSCLE_REGENERATION": "The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. [GOC:mtg_muscle]", "GOBP_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT": "The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. [GOC:BHF, GOC:vk]", "GOBP_SA_NODE_CELL_TO_ATRIAL_CARDIAC_MUSCLE_CELL_COMMUNICATION": "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_SCARNA_LOCALIZATION_TO_CAJAL_BODY": "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]", "GOBP_SA_NODE_CELL_TO_ATRIAL_CARDIAC_MUSCLE_CELL_SIGNALING": "", "GOBP_SCHWANN_CELL_MIGRATION": "", "GOBP_SCHWANN_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. [GOC:ef]", "GOBP_SCHWANN_CELL_PROLIFERATION": "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. [GOC:ef, ISBN:0878932585]", "GOBP_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. [PMID:15380083]", "GOBP_SEBACEOUS_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure. [GOC:jid]", "GOBP_SECONDARY_HEART_FIELD_SPECIFICATION": "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). [GOC:mtg_heart, GOC:rl, PMID:17276708]", "GOBP_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. [GOC:jl]", "GOBP_SECONDARY_METABOLIC_PROCESS": "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. [GOC:go_curators]", "GOBP_SECONDARY_PALATE_DEVELOPMENT": "The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences. [PMID:28784960]", "GOBP_SECRETORY_GRANULE_LOCALIZATION": "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. [GOC:mah]", "GOBP_SECRETION_OF_LYSOSOMAL_ENZYMES": "The controlled release of lysosomal enzymes by a cell. [GOC:mah]", "GOBP_SECRETORY_GRANULE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. [GOC:mah]", "GOBP_SEGMENT_SPECIFICATION": "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]", "GOBP_SECRETION": "The controlled release of a substance by a cell or a tissue. [GOC:ai]", "GOBP_SECRETION_BY_TISSUE": "The controlled release of a substance by a tissue. [GOC:mah]", "GOBP_SELF_PROTEOLYSIS": "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. [GOC:yaf, PMID:18676612, PMID:19144634]", "GOBP_SEGMENTATION": "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. [PMID:10611687, PMID:9706689]", "GOBP_SEMICIRCULAR_CANAL_DEVELOPMENT": "The progression of the semicircular canal from its initial formation to the mature structure. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]", "GOBP_SEMICIRCULAR_CANAL_MORPHOGENESIS": "The process in which the anatomical structures of the semicircular canals are generated and organized. [GOC:dgh, GOC:dph, GOC:jid]", "GOBP_SEMI_LUNAR_VALVE_DEVELOPMENT": "The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure. [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19409885]", "GOBP_SEMINIFEROUS_TUBULE_DEVELOPMENT": "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa. [GOC:BHF, GOC:mah, UBERON:0001343]", "GOBP_SENSORY_PERCEPTION_OF_BITTER_TASTE": "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_ORGAN_DEVELOPMENT": "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. [GOC:go_curators]", "GOBP_SENSORY_ORGAN_MORPHOGENESIS": "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:kmv, ISBN:978-0199210893]", "GOBP_SENSORY_PERCEPTION_OF_PAIN": "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. A painful stimulus is any physical or chemical event that has the potential to cause tissue damage (actual or perceived) and activates the nociceptive system. [GOC:curators]", "GOBP_SENSORY_PERCEPTION_OF_SOUR_TASTE": "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS": "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS": "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_PERCEPTION": "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai, GOC:dph]", "GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS": "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_PERCEPTION_OF_SWEET_TASTE": "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_PERCEPTION_OF_TASTE": "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_PERCEPTION_OF_SMELL": "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_PERCEPTION_OF_TOUCH": "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). [GOC:ai]", "GOBP_SENSORY_PERCEPTION_OF_UMAMI_TASTE": "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process. [GOC:ai]", "GOBP_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS": "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai]", "GOBP_SEPTUM_PRIMUM_DEVELOPMENT": "The progression of the septum primum over time, from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_SEQUESTERING_OF_ACTIN_MONOMERS": "", "GOBP_SEQUESTERING_OF_BMP_IN_EXTRACELLULAR_MATRIX": "Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins. [GOC:BHF, PMID:20855508]", "GOBP_SEQUESTERING_OF_CALCIUM_ION": "The process of binding or confining calcium ions such that they are separated from other components of a biological system. [GOC:ai]", "GOBP_SENSORY_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. [GOC:dgh]", "GOBP_SEQUESTERING_OF_EXTRACELLULAR_LIGAND_FROM_RECEPTOR": "The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor. [GOC:BHF, GOC:signaling]", "GOBP_SEQUESTERING_OF_IRON_ION": "", "GOBP_SEQUESTERING_OF_METAL_ION": "", "GOBP_SEQUESTERING_OF_TRIGLYCERIDE": "", "GOBP_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. [GOC:ai]", "GOBP_SERINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS": "", "GOBP_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN": "", "GOBP_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS": "", "GOBP_SERINE_TRANSPORT": "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_SEROTONERGIC_NEURON_AXON_GUIDANCE": "The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues. [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]", "GOBP_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. [GOC:mah]", "GOBP_SEROTONIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:jl, ISBN:0198506732]", "GOBP_SEROTONIN_TRANSPORT": "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. [GOC:ai]", "GOBP_SEROTONIN_SECRETION": "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. [GOC:ef, ISBN:0198506732, ISBN:0781735149]", "GOBP_SERTOLI_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. [GOC:dph]", "GOBP_SEROTONIN_UPTAKE": "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. [GOC:ai]", "GOBP_SERTOLI_CELL_PROLIFERATION": "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. [GOC:dph]", "GOBP_SERTOLI_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. [GOC:dph]", "GOBP_SEX_CHROMOSOME_DOSAGE_COMPENSATION": "", "GOBP_SEX_DETERMINATION": "Any process that establishes and transmits the specification of sexual status of an individual organism. [ISBN:0198506732]", "GOBP_SHORT_CHAIN_FATTY_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons. [ISBN:0198506732]", "GOBP_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons. [Wikipedia:Fatty_acid_metabolism]", "GOBP_SEX_DIFFERENTIATION": "The establishment of the sex of an organism by physical differentiation. [GOC:ai]", "GOBP_SIALYLATION": "The covalent attachment of sialic acid to a substrate molecule. [GOC:cjm]", "GOBP_SHORT_TERM_MEMORY": "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]", "GOBP_SIGNAL_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. [GOC:bf, GOC:signaling, PMID:9646862]", "GOBP_SIGNALING_RECEPTOR_LIGAND_PRECURSOR_PROCESSING": "The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand. [PMID:29247995]", "GOBP_SIGNAL_PEPTIDE_PROCESSING": "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. [GOC:mah, PMID:31214988]", "GOBP_SEXUAL_REPRODUCTION": "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). [Wikipedia:Sexual_reproduction]", "GOBP_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION": "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. [GOC:mtg_signal]", "GOBP_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND": "The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. [GOC:al, GOC:ppm, GOC:pr, PMID:15044679]", "GOBP_SINGLE_STRANDED_VIRAL_RNA_REPLICATION_VIA_DOUBLE_STRANDED_DNA_INTERMEDIATE": "A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II. [GOC:bf, GOC:jl, ISBN:0198506732, VZ:1937]", "GOBP_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR": "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. [GOC:mah]", "GOBP_SINGLE_STRAND_BREAK_REPAIR": "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. [PMID:18626472]", "GOBP_SINOATRIAL_NODE_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. [GOC:mtg_heart]", "GOBP_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE": "A cascade of processes induced by the detection of DNA damage within a cell. [GOC:go_curators]", "GOBP_SINGLE_FERTILIZATION": "The union of male and female gametes to form a zygote. [GOC:ems, GOC:mtg_sensu]", "GOBP_SINOATRIAL_NODE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. [GOC:mtg_heart]", "GOBP_SIGNAL_RELEASE": "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. [GOC:mtg_signal]", "GOBP_SINOATRIAL_NODE_DEVELOPMENT": "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. [GOC:mtg_heart]", "GOBP_SIRNA_PROCESSING": "A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase. [GOC:mah, PMID:11524674, PMID:19239886, PMID:20687832]", "GOBP_SIRNA_MEDIATED_RETROTRANSPOSON_SILENCING_BY_HETEROCHROMATIN_FORMATION": "", "GOBP_SKELETAL_MUSCLE_ACETYLCHOLINE_GATED_CHANNEL_CLUSTERING": "The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals. [GOC:bf, GOC:dsf, PMID:19285469]", "GOBP_SISTER_CHROMATID_COHESION": "The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. [GOC:jh, GOC:mah, ISBN:0815316194]", "GOBP_SKELETAL_MUSCLE_ADAPTATION": "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]", "GOBP_SISTER_CHROMATID_SEGREGATION": "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. [GOC:ai, GOC:elh]", "GOBP_SKELETAL_MUSCLE_ATROPHY": "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. [GOC:mtg_muscle]", "GOBP_SKELETAL_MUSCLE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. [CL:0000188, GOC:BHF, GOC:vk]", "GOBP_SKELETAL_MUSCLE_CELL_PROLIFERATION": "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. [CL:0000188, GOC:ef, GOC:mtg_muscle]", "GOBP_SKELETAL_MUSCLE_CONTRACTION": "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. [GOC:mtg_cardio, GOC:mtg_muscle]", "GOBP_SKELETAL_MUSCLE_FIBER_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. [GOC:dos]", "GOBP_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT": "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. [GOC:dph]", "GOBP_SKELETAL_MUSCLE_SATELLITE_CELL_ACTIVATION": "The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. [GOC:mtg_muscle, PMID:23303905]", "GOBP_SKELETAL_MUSCLE_SATELLITE_CELL_MAINTENANCE_INVOLVED_IN_SKELETAL_MUSCLE_REGENERATION": "Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells. [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:23303905]", "GOBP_SKELETAL_MUSCLE_SATELLITE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell. [GOC:ef, GOC:mtg_muscle, PMID:16607119]", "GOBP_SKELETAL_MUSCLE_SATELLITE_CELL_PROLIFERATION": "", "GOBP_SKELETAL_MUSCLE_THIN_FILAMENT_ASSEMBLY": "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle. [GOC:ef, GOC:mah, GOC:mtg_muscle]", "GOBP_SKELETAL_MUSCLE_TISSUE_GROWTH": "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. [GOC:lm, PMID:15726494, PMID:15907921]", "GOBP_SKELETAL_MYOFIBRIL_ASSEMBLY": "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. [GOC:ef, GOC:mtg_muscle]", "GOBP_SKELETAL_MUSCLE_TISSUE_REGENERATION": "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119]", "GOBP_SKELETAL_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). [GOC:dph, GOC:jid, GOC:tb]", "GOBP_SKIN_MORPHOGENESIS": "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. [GOC:jl, UBERON:0002097]", "GOBP_SLEEP": "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. [ISBN:0192800981]", "GOBP_SKIN_EPIDERMIS_DEVELOPMENT": "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. [GOC:dos]", "GOBP_SKELETAL_SYSTEM_MORPHOGENESIS": "The process in which the anatomical structures of the skeleton are generated and organized. [GOC:dph, GOC:dsf, GOC:jid, GOC:tb]", "GOBP_SKIN_DEVELOPMENT": "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. [GOC:jl, UBERON:0002097]", "GOBP_SMAD_PROTEIN_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes. [GOC:BHF]", "GOBP_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex. [GOC:krc]", "GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION": "An intracellular signaling cassette in which a small monomeric GTPase relays a signal. [GOC:mah]", "GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:vw]", "GOBP_SMOOTHENED_SIGNALING_PATHWAY_INVOLVED_IN_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING": "", "GOBP_SMOOTH_MUSCLE_ADAPTATION": "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle]", "GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:pde, GOC:vw]", "GOBP_SMOOTH_MUSCLE_CELL_CHEMOTAXIS": "The directed movement of a smooth muscle cell in response to an external stimulus. [GOC:mah]", "GOBP_SMOOTHENED_SIGNALING_PATHWAY": "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. [GOC:mah, PMID:15057936, PMID:15205520]", "GOBP_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]", "GOBP_SMALL_MOLECULE_METABOLIC_PROCESS": "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:pde, GOC:vw]", "GOBP_SMOOTH_MUSCLE_CELL_MATRIX_ADHESION": "The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules. [GOC:BHF, GOC:dph, PMID:8837777]", "GOBP_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. [CL:0000192, GOC:ai]", "GOBP_SMOOTH_MUSCLE_CELL_MIGRATION": "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. [CL:0000192, GOC:mtg_muscle]", "GOBP_SMOOTH_MUSCLE_CONTRACTION": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]", "GOBP_SNARE_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb, PMID:10872468]", "GOBP_SNO_S_RNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. [GOC:krc]", "GOBP_SNORNA_LOCALIZATION": "Any process in which small nucleolar RNA is transported to, or maintained in, a specific location. [ISBN:0716731363]", "GOBP_SMOOTH_MUSCLE_CELL_PROLIFERATION": "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. [CL:0000192, GOC:ebc, PMID:1840698]", "GOBP_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT": "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. [GOC:dph, GOC:jid, GOC:lm]", "GOBP_SNO_S_RNA_PROCESSING": "Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea). [GOC:go_curators, GOC:krc, PMID:12773397]", "GOBP_SNRNA_3_END_PROCESSING": "Any process involved in forming the mature 3' end of an snRNA molecule. [GOC:mah]", "GOBP_SNRNA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. [ISBN:0198506732]", "GOBP_SNRNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. [ISBN:0198506732]", "GOBP_SNRNA_MODIFICATION": "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA. [GOC:jl]", "GOBP_SNRNA_PROCESSING": "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres. [PMID:15196465, PMID:31815536]", "GOBP_SNRNA_TRANSCRIPTION": "The synthesis of small nuclear RNA (snRNA) from a DNA template. [GOC:jl, ISBN:0321000382]", "GOBP_SNRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_II": "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. [GOC:jl, ISBN:0321000382]", "GOBP_SODIUM_DEPENDENT_PHOSPHATE_TRANSPORT": "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions. [GOC:BHF, GOC:jl]", "GOBP_SNRNA_TRANSCRIPTION_BY_RNA_POLYMERASE_III": "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. [GOC:jl, ISBN:0321000382]", "GOBP_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT": "The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]", "GOBP_SODIUM_ION_EXPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689]", "GOBP_SNRNA_TRANSPORT": "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_SODIUM_ION_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]", "GOBP_SODIUM_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]", "GOBP_SOFT_PALATE_DEVELOPMENT": "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate. [GOC:dph, ISBN:0721662544]", "GOBP_SODIUM_ION_TRANSMEMBRANE_TRANSPORT": "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]", "GOBP_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION": "The process in which immune receptor genes are diversified through somatic mutation. [ISBN:0781735149, PMID:16102575]", "GOBP_SODIUM_ION_TRANSPORT": "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_SOMATIC_MOTOR_NEURON_DIFFERENTIATION": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]", "GOBP_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS": "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]", "GOBP_SOMATIC_STEM_CELL_DIVISION": "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. [GOC:jid, ISBN:0582227089]", "GOBP_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS": "The somatic process that results in the generation of sequence diversity of immunoglobulins. [GOC:add, GOC:ma, ISBN:0781735149]", "GOBP_SOMATOSTATIN_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:jc, PMID:18006219, PMID:8769369]", "GOBP_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE": "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. [GOC:bf, ISBN:0582227089]", "GOBP_SOMATOTROPIN_SECRETING_CELL_DIFFERENTIATION": "", "GOBP_SOMITE_ROSTRAL_CAUDAL_AXIS_SPECIFICATION": "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary. [GOC:bf, PMID:16326386, PMID:17360776]", "GOBP_SOMITE_SPECIFICATION": "The process in which individual somites establish identity during embryogenesis. [GOC:dph]", "GOBP_SOMITE_DEVELOPMENT": "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. [GOC:dph]", "GOBP_SPECIFICATION_OF_ANIMAL_ORGAN_IDENTITY": "The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. [GOC:tb]", "GOBP_SOMITOGENESIS": "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. [ISBN:0721662544]", "GOBP_SPERMATID_NUCLEUS_DIFFERENTIATION": "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. [GOC:bf, GOC:dph, GOC:jl, GOC:mah]", "GOBP_SPERMIDINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]", "GOBP_SPECIFICATION_OF_SYMMETRY": "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. [GOC:go_curators]", "GOBP_SPERMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. [GOC:curators]", "GOBP_SPERMIDINE_TRANSPORT": "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc, ISBN:0198506732]", "GOBP_SPERMATID_DIFFERENTIATION": "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. [GOC:dph, GOC:jid]", "GOBP_SPERM_AXONEME_ASSEMBLY": "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. [GOC:bf, GOC:cilia, ISBN:0198547684]", "GOBP_SPERM_DNA_CONDENSATION": "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication. [GOC:bf, PMID:11735001]", "GOBP_SPERM_CAPACITATION": "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]", "GOBP_SPERM_EJACULATION": "", "GOBP_SPERM_EGG_RECOGNITION": "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. [GOC:bf]", "GOBP_SPERM_MITOCHONDRIAL_SHEATH_ASSEMBLY": "The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. [GOC:krc, PMID:32791035]", "GOBP_SPERM_MOTILITY": "", "GOBP_SPHINGOID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. [ISBN:0198506732]", "GOBP_SPERM_FLAGELLUM_ASSEMBLY": "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium). [GOC:krc, PMID:32791035]", "GOBP_SPHINGOID_METABOLIC_PROCESS": "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. [ISBN:0198506732]", "GOBP_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals mediated by a sphingolipid. [PMID:9525917]", "GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732]", "GOBP_SPHINGOMYELIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]", "GOBP_SPHINGOMYELIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]", "GOBP_SPHINGOMYELIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. [ISBN:0198506732]", "GOBP_SPHINGOSINE_1_PHOSPHATE_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186]", "GOBP_SPHINGOLIPID_METABOLIC_PROCESS": "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732]", "GOBP_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]", "GOBP_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION": "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_SPINAL_CORD_DEVELOPMENT": "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION": "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]", "GOBP_SPINAL_CORD_OLIGODENDROCYTE_CELL_DIFFERENTIATION": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_SPINAL_CORD_PATTERNING": "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_SPINDLE_ASSEMBLY_INVOLVED_IN_FEMALE_MEIOSIS": "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. [GOC:mah]", "GOBP_SPINDLE_ELONGATION": "The cell cycle process in which the distance is lengthened between poles of the spindle. [GOC:ai]", "GOBP_SPINDLE_LOCALIZATION": "Any process in which is the spindle is transported to, and/or maintained in, a specific location. [GOC:ai]", "GOBP_SPINDLE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]", "GOBP_SPINDLE_MIDZONE_ASSEMBLY": "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. [GOC:ai, PMID:15296749]", "GOBP_SPLEEN_DEVELOPMENT": "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. [GOC:add, ISBN:0781735149]", "GOBP_SPINDLE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. [GOC:go_curators, GOC:mah]", "GOBP_SPLICEOSOMAL_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. [PMID:9476892]", "GOBP_SPLICEOSOMAL_SNRNP_ASSEMBLY": "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. [GOC:krc, GOC:mah, ISBN:0879695897]", "GOBP_SPLICEOSOMAL_CONFORMATIONAL_CHANGES_TO_GENERATE_CATALYTIC_CONFORMATION": "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. [GOC:krc]", "GOBP_SPONTANEOUS_NEUROTRANSMITTER_SECRETION": "Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential. [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]", "GOBP_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY": "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. [ISBN:0879695897, PMID:9452384]", "GOBP_SPONTANEOUS_SYNAPTIC_TRANSMISSION": "The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential. [PMID:20200227]", "GOBP_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE_SIGNAL_SEQUENCE_RECOGNITION": "The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting. [ISBN:0815316194]", "GOBP_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE": "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. [ISBN:0716731363]", "GOBP_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE_TRANSLOCATION": "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. [ISBN:0716731363]", "GOBP_STABILIZATION_OF_MEMBRANE_POTENTIAL": "", "GOBP_SPROUTING_ANGIOGENESIS": "The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. [PMID:16391003, PMID:23031691]", "GOBP_STARTLE_RESPONSE": "An action or movement due to the application of a sudden unexpected stimulus. [GOC:dph]", "GOBP_STEM_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. [CL:0000034, GOC:isa_complete]", "GOBP_STEM_CELL_DIVISION": "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. [GOC:jid, ISBN:0582227089]", "GOBP_STEM_CELL_FATE_COMMITMENT": "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell. [CL:0000034, GOC:isa_complete]", "GOBP_STEM_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [CL:0000034, GOC:isa_complete]", "GOBP_STEM_CELL_FATE_SPECIFICATION": "", "GOBP_STEROID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:go_curators]", "GOBP_STEM_CELL_PROLIFERATION": "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [GOC:mtg_kidney_jan10]", "GOBP_STEROID_HORMONE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:krc, GOC:nln]", "GOBP_STEROID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators]", "GOBP_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY": "", "GOBP_STEROID_HORMONE_SECRETION": "The regulated release of any steroid that acts as a hormone into the circulatory system. [GOC:sl]", "GOBP_STEROL_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:go_curators]", "GOBP_STEROID_METABOLIC_PROCESS": "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]", "GOBP_STEROL_HOMEOSTASIS": "Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. [GOC:BHF, GOC:rl]", "GOBP_STOMACH_DEVELOPMENT": "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. [PMID:11967278]", "GOBP_STORE_OPERATED_CALCIUM_ENTRY": "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. [GOC:hjd, PMID:11120592, PMID:17956991]", "GOBP_STEROL_METABOLIC_PROCESS": "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [ISBN:0198547684]", "GOBP_STEROL_TRANSPORT": "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:ai]", "GOBP_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE": "The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal. [GOC:mah]", "GOBP_STRESS_FIBER_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. [GOC:go_curators, GOC:mah, PMID:16651381]", "GOBP_STRESS_GRANULE_ASSEMBLY": "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. [GOC:mah, PMID:17392519]", "GOBP_STRESS_GRANULE_DISASSEMBLY": "The disaggregation of a stress granule into its constituent protein and RNA parts. [GOC:BHF, PMID:19825938]", "GOBP_STRESS_INDUCED_PREMATURE_SENESCENCE": "A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays. [GOC:BHF]", "GOBP_STRIATED_MUSCLE_ATROPHY": "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. [GOC:mtg_muscle]", "GOBP_STRIATED_MUSCLE_ADAPTATION": "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. [GOC:mtg_muscle]", "GOBP_STRIATED_MUSCLE_CELL_DEVELOPMENT": "", "GOBP_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS": "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "GOBP_STRIATED_MUSCLE_CELL_PROLIFERATION": "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. [CL:0000737, GOC:ef, GOC:mtg_muscle]", "GOBP_STRIATUM_DEVELOPMENT": "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]", "GOBP_SUBPALLIUM_DEVELOPMENT": "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_STRIATED_MUSCLE_TISSUE_DEVELOPMENT": "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. [CL:0000737, GOC:dph, GOC:mtg_muscle]", "GOBP_STRIATED_MUSCLE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. [CL:0000737, GOC:ai]", "GOBP_STRIATED_MUSCLE_CONTRACTION": "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. [GOC:jl, GOC:mtg_muscle, ISBN:0198506732]", "GOBP_SUBSTANTIA_NIGRA_DEVELOPMENT": "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420]", "GOBP_SUBSTRATE_DEPENDENT_CELL_MIGRATION": "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. [ISBN:0815316194, PMID:11944043, PMID:14657486]", "GOBP_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING": "The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. [GOC:mah, GOC:pf, PMID:17050732]", "GOBP_SUBSTRATE_DEPENDENT_CELL_MIGRATION_CELL_EXTENSION": "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. [ISBN:0815316194, PMID:11944043, PMID:14657486]", "GOBP_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION": "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_SUBTELOMERIC_HETEROCHROMATIN_FORMATION": "The compaction of chromatin into heterochromatin at the subtelomeric region. [GOC:mah, PMID:10219245, PMID:26205977]", "GOBP_SUCCINATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle. [ISBN:0198506732]", "GOBP_SUCCINATE_TRANSMEMBRANE_TRANSPORT": "The process in which succinate is transported across a membrane. [GOC:mah]", "GOBP_SUCCINYL_COA_METABOLIC_PROCESS": "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A. [GOC:ai]", "GOBP_SUCCINYL_COA_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of succinyl-CoA. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929]", "GOBP_SUGAR_MEDIATED_SIGNALING_PATHWAY": "The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes. [PMID:9014361]", "GOBP_SUCKLING_BEHAVIOR": "Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. [GOC:dph, GOC:pr]", "GOBP_SULFATE_TRANSPORT": "", "GOBP_SULFATION": "The addition of a sulfate group to a molecule. [Wikipedia:Sulfation]", "GOBP_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. [GOC:ai]", "GOBP_SULFUR_AMINO_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. [GOC:ai]", "GOBP_SULFUR_AMINO_ACID_TRANSPORT": "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_SULFUR_COMPOUND_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. [GOC:jl]", "GOBP_SULFUR_AMINO_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. [GOC:ai]", "GOBP_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. [GOC:jl]", "GOBP_SULFUR_COMPOUND_TRANSPORT": "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_SUPPRESSION_OF_VIRAL_RELEASE_BY_HOST": "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells. [GOC:jl, PMID:18305167]", "GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. [GOC:ai]", "GOBP_SUPEROXIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. [GOC:jl]", "GOBP_SUPEROXIDE_ANION_GENERATION": "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. [GOC:jl, PMID:12359750]", "GOBP_SURFACTANT_HOMEOSTASIS": "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid. [PMID:23708874, PMID:9751757]", "GOBP_SYMPATHETIC_GANGLION_DEVELOPMENT": "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. [GOC:BHF, GOC:rl]", "GOBP_SYMBIONT_ENTRY_INTO_HOST": "Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:vw]", "GOBP_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. [FMA:9906, GOC:jid, GOC:sr]", "GOBP_SYMPATHETIC_NEURON_PROJECTION_EXTENSION": "Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:BHF, GOC:rl, PMID:22790009]", "GOBP_SUPRAMOLECULAR_FIBER_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:pr]", "GOBP_SYNAPSE_MATURATION": "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development. [GOC:dph, GOC:ef]", "GOBP_SYNAPSE_PRUNING": "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190]", "GOBP_SYNAPTIC_ASSEMBLY_AT_NEUROMUSCULAR_JUNCTION": "The assembly of a synapse at a neuromuscular junction. [PMID:20215342]", "GOBP_SYNAPSE_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). [GOC:mah]", "GOBP_SYNAPTIC_MEMBRANE_ADHESION": "The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. [GOC:dos]", "GOBP_SYNAPTIC_SIGNALING_VIA_NEUROPEPTIDE": "Cell-cell signaling to or from a synapse, mediated by a peptide. [GOC:dos]", "GOBP_SYNAPSE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai, GOC:pr]", "GOBP_SYNAPTIC_TRANSMISSION_CHOLINERGIC": "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, Wikipedia:Cholinergic]", "GOBP_SYNAPTIC_TRANSMISSION_DOPAMINERGIC": "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, GOC:dph]", "GOBP_SYNAPTIC_TRANSMISSION_GLYCINERGIC": "The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos]", "GOBP_SYNAPTIC_TRANSMISSION_GABAERGIC": "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos, ISBN:0126603030]", "GOBP_SYNAPTIC_SIGNALING": "Cell-cell signaling to, from or within a synapse. [GOC:dos]", "GOBP_SYNAPTIC_VESICLE_BUDDING": "Evagination of a membrane to form a synaptic vesicle. [GOC:mah]", "GOBP_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC": "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos]", "GOBP_SYNAPTIC_VESICLE_CLUSTERING": "The process that results in grouping synaptic vesicles in presynaptic structures. [GOC:ans, GOC:pr, PMID:19900895, PMID:7568108]", "GOBP_SYNAPTIC_VESICLE_COATING": "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles. [GOC:curators, PMID:10099709, PMID:20448150]", "GOBP_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT": "The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. [GOC:dos]", "GOBP_SYNAPTIC_VESICLE_DOCKING": "The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process. [PMID:15217342]", "GOBP_SYNAPTIC_VESICLE_ENDOSOMAL_PROCESSING": "The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. [GOC:aruk, GOC:bc, GOC:dos]", "GOBP_SYNAPTIC_VESICLE_EXOCYTOSIS": "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. [GOC:jid, GOC:lmg]", "GOBP_SYNAPTIC_VESICLE_MATURATION": "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle. [GOC:curators, PMID:10099709]", "GOBP_SYNAPTIC_VESICLE_LUMEN_ACIDIFICATION": "The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading. [GOC:dsf, PMID:21172605, PMID:22875945]", "GOBP_SYNAPTIC_VESICLE_LOCALIZATION": "Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. [GOC:pr]", "GOBP_SYNAPTIC_VESICLE_PRIMING": "A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. [GOC:mah, PMID:15217342, PMID:23060190]", "GOBP_SYNAPTIC_VESICLE_RECYCLING_VIA_ENDOSOME": "Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate. [GOC:aruk, GOC:bc, GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342]", "GOBP_SYNAPTIC_VESICLE_MEMBRANE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle. [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]", "GOBP_SYNAPTIC_VESICLE_UNCOATING": "", "GOBP_SYNAPTIC_VESICLE_RECYCLING": "The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane. [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]", "GOBP_SYNAPTIC_VESICLE_TRANSPORT": "The directed movement of synaptic vesicles. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr]", "GOBP_SYNAPTONEMAL_COMPLEX_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. [GOC:mah]", "GOBP_SYNCYTIUM_FORMATION": "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. [ISBN:0198506732]", "GOBP_SYNOVIOCYTE_PROLIFERATION": "The multiplication or reproduction of type B synoviocytes by cell division, resulting in the expansion of their population. A type B synoviocyte is a fibroblast-like cell found in synovial tissues. [PMID:10770586, PMID:9546370]", "GOBP_S_ADENOSYLMETHIONINE_CYCLE": "", "GOBP_S_SHAPED_BODY_MORPHOGENESIS": "The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron. [GOC:mtg_kidney_jan10]", "GOBP_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. [GOC:go_curators, ISBN:0198506732]", "GOBP_TACHYKININ_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2). [GOC:mah, PMID:14723970]", "GOBP_TAIL_ANCHORED_MEMBRANE_PROTEIN_INSERTION_INTO_ER_MEMBRANE": "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region. [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]", "GOBP_TANGENTIAL_MIGRATION_FROM_THE_SUBVENTRICULAR_ZONE_TO_THE_OLFACTORY_BULB": "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_TAURINE_METABOLIC_PROCESS": "", "GOBP_TELOMERASE_RNA_LOCALIZATION": "Any process in which telomerase RNA is transported to, or maintained in, a specific location. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444]", "GOBP_TELENCEPHALON_REGIONALIZATION": "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators]", "GOBP_TELENCEPHALON_GLIAL_CELL_MIGRATION": "The orderly movement of glial cells through the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_TELOMERASE_HOLOENZYME_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form a telomerase holoenzyme complex. [GO_REF:0000079, GOC:TermGenie, PMID:26305931]", "GOBP_TELENCEPHALON_DEVELOPMENT": "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]", "GOBP_TELOMERE_CAPPING": "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]", "GOBP_TELOMERE_LOCALIZATION": "Any process in which a telomere is transported to, and/or maintained in, a specific location. [GOC:mah, GOC:vw]", "GOBP_TELOMERE_MAINTENANCE": "", "GOBP_TAXIS": "The directed movement of a motile cell or organism in response to an external stimulus. [GOC:jl, ISBN:0192801023]", "GOBP_TELOMERE_MAINTENANCE_IN_RESPONSE_TO_DNA_DAMAGE": "Any process that occur in response to the presence of critically short or damaged telomeres. [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784]", "GOBP_TELOMERE_MAINTENANCE_VIA_SEMI_CONSERVATIVE_REPLICATION": "The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication. [GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:vw, PMID:16598261]", "GOBP_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING": "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. [GOC:dph, GOC:tb]", "GOBP_TELOMERE_TETHERING_AT_NUCLEAR_PERIPHERY": "The process in which a telomere is maintained in a specific location at the nuclear periphery. [GOC:mah]", "GOBP_TELOMERE_MAINTENANCE_VIA_RECOMBINATION": "Any recombinational process that contributes to the maintenance of proper telomeric length. [GOC:elh, PMID:11850777]", "GOBP_TELOMERIC_D_LOOP_DISASSEMBLY": "A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:10338204, PMID:24012755]", "GOBP_TENDON_DEVELOPMENT": "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. [GOC:yaf, PMID:21412429, UBERON:0000043]", "GOBP_TELOMERIC_LOOP_DISASSEMBLY": "The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:22579284]", "GOBP_TERMINAL_BUTTON_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. [GOC:BHF, GOC:mah]", "GOBP_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION": "A transcription termination process that completes the production of a primary RNA polymerase II transcript. [GOC:mah, GOC:txnOH, PMID:27371117]", "GOBP_TELOMERE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_TERPENOID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. [GOC:ai]", "GOBP_TEMPERATURE_HOMEOSTASIS": "A homeostatic process in which an organism modulates its internal body temperature. [GOC:jl]", "GOBP_TERPENOID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. [GOC:ai]", "GOBP_TERTIARY_ALCOHOL_METABOLIC_PROCESS": "The chemical reactions and pathways involving tertiary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]", "GOBP_TERPENOID_METABOLIC_PROCESS": "", "GOBP_TETRAHYDROBIOPTERIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. [PMID:21871890]", "GOBP_TETRAHYDROFOLATE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. [ISBN:0198506732]", "GOBP_TESTOSTERONE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5. [GOC:dph, GOC:yaf]", "GOBP_TETRAHYDROFOLATE_INTERCONVERSION": "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules. [GOC:yaf, PMID:1825999]", "GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. [GOC:mah]", "GOBP_TETRAPYRROLE_CATABOLIC_PROCESS": "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. [GOC:mah]", "GOBP_TETRAHYDROFOLATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. [ISBN:0198506732]", "GOBP_TETRAPYRROLE_METABOLIC_PROCESS": "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. [GOC:mah]", "GOBP_THELARCHE": "The beginning of development of the breasts in the female. [GOC:curators, PMID:19117864]", "GOBP_THALAMUS_DEVELOPMENT": "The process in which the thalamus changes over time, from its initial formation to its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_THERMOCEPTION": "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). [GOC:ai, Wikipedia:Thermoception]", "GOBP_THIAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS": "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it. [GOC:jl]", "GOBP_THIAMINE_DIPHOSPHATE_METABOLIC_PROCESS": "", "GOBP_THIAMINE_TRANSPORT": "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:ai]", "GOBP_THIOESTER_BIOSYNTHETIC_PROCESS": "", "GOBP_THORAX_AND_ANTERIOR_ABDOMEN_DETERMINATION": "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]", "GOBP_THREONINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]", "GOBP_THROMBIN_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY": "A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, PMID:1672265]", "GOBP_THROMBOPOIETIN_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by thrombopoietin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:19630807]", "GOBP_THYMOCYTE_MIGRATION": "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development. [CL:0000893, GOC:BHF, GOC:mah]", "GOBP_THYMOCYTE_APOPTOTIC_PROCESS": "Any apoptotic process in a thymocyte, an immature T cell located in the thymus. [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_THYMIC_T_CELL_SELECTION": "The process of T cell selection that occurs in the thymus. [ISBN:0781735149, PMID:12414722]", "GOBP_THYROID_GLAND_DEVELOPMENT": "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. [GOC:dgh]", "GOBP_THYMUS_DEVELOPMENT": "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. [GOC:add, ISBN:0781735149]", "GOBP_THYROID_HORMONE_GENERATION": "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. [GOC:jl, ISBN:0716720094]", "GOBP_THYROID_HORMONE_TRANSPORT": "The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:rph]", "GOBP_THYROID_HORMONE_METABOLIC_PROCESS": "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:jl, ISBN:0198506732]", "GOBP_THYROID_HORMONE_MEDIATED_SIGNALING_PATHWAY": "", "GOBP_THYROID_STIMULATING_HORMONE_SECRETING_CELL_DIFFERENTIATION": "", "GOBP_TIGHT_JUNCTION_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. [GOC:krc, GOC:rl]", "GOBP_TISSUE_MIGRATION": "The process in which the population of cells that make up a tissue undergo directed movement. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_TISSUE_REGENERATION": "The regrowth of lost or destroyed tissues. [GOC:curators]", "GOBP_TOLERANCE_INDUCTION_DEPENDENT_UPON_IMMUNE_RESPONSE": "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation. [GO_REF:0000022, GOC:jal, ISBN:0781735149]", "GOBP_TISSUE_HOMEOSTASIS": "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. [GOC:add, GOC:isa_complete]", "GOBP_TOLERANCE_INDUCTION_TO_SELF_ANTIGEN": "Tolerance induction directed at self antigens. [GO_REF:0000022, GOC:jal, ISBN:0781735149]", "GOBP_TOLERANCE_INDUCTION": "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. [GO_REF:0000022, GOC:jal, ISBN:0781735149]", "GOBP_TISSUE_REMODELING": "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. [GOC:ebc]", "GOBP_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to toll-like receptor 2. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_TISSUE_MORPHOGENESIS": "The process in which the anatomical structures of a tissue are generated and organized. [GOC:dph, GOC:jid]", "GOBP_TOLL_LIKE_RECEPTOR_3_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY": "", "GOBP_TOLL_LIKE_RECEPTOR_7_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 7. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 9. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_TOLL_LIKE_RECEPTOR_8_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 8. [GOC:add, PMID:16551253, PMID:17328678]", "GOBP_TOLL_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:go_curators, PMID:11135568, PMID:19126860]", "GOBP_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]", "GOBP_TONGUE_MORPHOGENESIS": "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. [GOC:jl, UBERON:0001723]", "GOBP_TONGUE_DEVELOPMENT": "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. [GOC:jl, UBERON:0001723]", "GOBP_TOOTH_ERUPTION": "The tooth development process in which the teeth enter the mouth and become visible. [Wikipedia:Tooth_eruption]", "GOBP_TONIC_SMOOTH_MUSCLE_CONTRACTION": "A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction. [GOC:mtg_muscle]", "GOBP_TOOTH_MINERALIZATION": "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. [GOC:mah, MP:0002817, MSH:D014074]", "GOBP_TORC2_SIGNALING": "A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. [GOC:lb]", "GOBP_TORC1_SIGNALING": "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. [GOC:lb]", "GOBP_TOR_SIGNALING": "The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. [PMID:12372295]", "GOBP_TRABECULA_FORMATION": "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. [GOC:dph]", "GOBP_TOXIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [GOC:cab2]", "GOBP_TRACHEA_DEVELOPMENT": "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. [GOC:dph]", "GOBP_TRACHEA_CARTILAGE_DEVELOPMENT": "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]", "GOBP_TRACHEA_FORMATION": "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. [GOC:dph]", "GOBP_TRABECULA_MORPHOGENESIS": "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. [GOC:dph]", "GOBP_TRACHEA_MORPHOGENESIS": "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. [GOC:dph]", "GOBP_TRAIL_ACTIVATED_APOPTOTIC_SIGNALING_PATHWAY": "An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface. [GOC:bf, GOC:PARL, PMID:21785459]", "GOBP_TRANSCRIPTION_BY_RNA_POLYMERASE_I": "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. [GOC:jl, GOC:txnOH]", "GOBP_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR": "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. [PMID:10197977, PMID:11900249]", "GOBP_TRANSCRIPTION_BY_RNA_POLYMERASE_III": "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. [GOC:jl, GOC:txnOH, PMID:12381659]", "GOBP_TRANSCRIPTION_ELONGATION_COUPLED_CHROMATIN_REMODELING": "A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation. [PMID:22922743, PMID:28053344]", "GOBP_TRANSCRIPTION_DEPENDENT_TETHERING_OF_RNA_POLYMERASE_II_GENE_DNA_AT_NUCLEAR_PERIPHERY": "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript. [GOC:krc, PMID:18614049]", "GOBP_TRANSCRIPTION_ELONGATION_BY_RNA_POLYMERASE_I": "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I. [GOC:mah, GOC:txnOH]", "GOBP_TRANSCRIPTION_INITIATION_AT_RNA_POLYMERASE_III_PROMOTER": "A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III. [GOC:mah, GOC:txnOH]", "GOBP_TRANSCRIPTION_INITIATION_AT_RNA_POLYMERASE_I_PROMOTER": "A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I. [GOC:txnOH]", "GOBP_TRANSCYTOSIS": "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. [ISBN:0716731363]", "GOBP_TRANSCRIPTION_PREINITIATION_COMPLEX_ASSEMBLY": "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides. [GOC:txnOH]", "GOBP_TRANSCRIPTION_INITIATION_AT_RNA_POLYMERASE_II_PROMOTER": "A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II. [GOC:mah, GOC:txnOH]", "GOBP_TRANSDIFFERENTIATION": "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate. [GOC:dph, GOC:kmv]", "GOBP_TRANSEPITHELIAL_CHLORIDE_TRANSPORT": "The directed movement of chloride ions from one side of an epithelium to the other. [GOC:mah]", "GOBP_TRANSFORMING_GROWTH_FACTOR_BETA1_PRODUCTION": "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_TRANSFERRIN_TRANSPORT": "The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mlg]", "GOBP_TRANSEPITHELIAL_TRANSPORT": "The directed movement of a substance from one side of an epithelium to the other. [GOC:mah, GOC:yaf, ISBN:0716731363]", "GOBP_TRANSFORMING_GROWTH_FACTOR_BETA2_PRODUCTION": "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:mah]", "GOBP_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION": "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3. [GOC:add, GOC:rv, PMID:16891311, PMID:2022183]", "GOBP_TRANSITION_BETWEEN_FAST_AND_SLOW_FIBER": "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. [GOC:ef, GOC:mtg_muscle]", "GOBP_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, GOC:signaling]", "GOBP_TRANSITION_METAL_ION_TRANSPORT": "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732]", "GOBP_TRANSLATIONAL_READTHROUGH": "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons. [GOC:jsg, PMID:11179232]", "GOBP_TRANSLATIONAL_INITIATION": "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [ISBN:019879276X]", "GOBP_TRANSLATIONAL_TERMINATION": "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). [GOC:hjd, ISBN:019879276X]", "GOBP_TRANSLATIONAL_ELONGATION": "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. [GOC:ems]", "GOBP_TRANSLATION": "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]", "GOBP_TRANSLESION_SYNTHESIS": "", "GOBP_TRANSMISSION_OF_NERVE_IMPULSE": "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. [GOC:curators, ISBN:0815316194]", "GOBP_TRANSPORT_OF_VIRUS": "The directed movement of a virus, or part of a virus, into, out of, or within a host cell. [GOC:ai]", "GOBP_TRANSPOSITION": "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site. [ISBN:1555812090, PMID:14682279, PMID:25893143]", "GOBP_TRANS_SYNAPTIC_SIGNALING_MODULATING_SYNAPTIC_TRANSMISSION": "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. [GOC:dos]", "GOBP_TRANS_SYNAPTIC_SIGNALING_BY_TRANS_SYNAPTIC_COMPLEX": "Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex. [GOC:dos]", "GOBP_TRANS_SYNAPTIC_SIGNALING_BY_LIPID": "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. [GOC:dos]", "GOBP_TRANS_SYNAPTIC_SIGNALING_BY_BDNF": "", "GOBP_TRANSMEMBRANE_TRANSPORT": "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]", "GOBP_TRICARBOXYLIC_ACID_CYCLE": "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. [ISBN:0198506732]", "GOBP_TRICARBOXYLIC_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). [GOC:mah]", "GOBP_TRICARBOXYLIC_ACID_TRANSPORT": "The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_TRIF_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GOC:BHF, PMID:12855817]", "GOBP_TRICUSPID_VALVE_DEVELOPMENT": "The progression of the tricuspid valve over time, from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_TRIGEMINAL_NERVE_DEVELOPMENT": "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_TRIGLYCERIDE_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. [ISBN:0198506732]", "GOBP_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS": "", "GOBP_TRIPARTITE_REGIONAL_SUBDIVISION": "", "GOBP_TRIGLYCERIDE_METABOLIC_PROCESS": "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. [ISBN:0198506732]", "GOBP_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_REMODELING": "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]", "GOBP_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_CLEARANCE": "The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF]", "GOBP_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORT": "The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds. [GOC:vw]", "GOBP_TRNA_3_END_PROCESSING": "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA. [GOC:go_curators]", "GOBP_TRIPEPTIDE_TRANSPORT": "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]", "GOBP_TRNA_5_END_PROCESSING": "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA. [GOC:dos, GOC:pf, PMID:27484477]", "GOBP_TRNA_5_LEADER_REMOVAL": "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. [PMID:11592395]", "GOBP_TRNA_AMINOACYLATION_FOR_MITOCHONDRIAL_PROTEIN_TRANSLATION": "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion. [GOC:mah]", "GOBP_TRNA_DECAY": "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. [GOC:ai]", "GOBP_TRNA_MODIFICATION": "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. [GOC:curators]", "GOBP_TRNA_METHYLATION": "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. [GOC:mah]", "GOBP_TRNA_PSEUDOURIDINE_SYNTHESIS": "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. [GOC:mah]", "GOBP_TRNA_PROCESSING": "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. [GOC:jl, PMID:12533506]", "GOBP_TRNA_SURVEILLANCE": "The set of processes involved in identifying and degrading defective or aberrant tRNAs. [GOC:mah, PMID:32841241]", "GOBP_TRNA_METABOLIC_PROCESS": "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. [ISBN:0198506732]", "GOBP_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. [GOC:imk, GOC:mah, PMID:19287007]", "GOBP_TRNA_THIO_MODIFICATION": "The addition a sulfur atom to a nucleotide in a tRNA molecule. [GOC:mcc, PMID:12549933, PMID:14722066]", "GOBP_TRNA_THREONYLCARBAMOYLADENOSINE_MODIFICATION": "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). [GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]", "GOBP_TRNA_TRANSCRIPTION": "The synthesis of transfer RNA (tRNA) from a DNA template. [GOC:jl]", "GOBP_TRNA_TRANSPORT": "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_TRNA_WOBBLE_BASE_MODIFICATION": "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence  (position 34) corresponds to the first position of the anticodon. [PMID:28812932]", "GOBP_TROPHECTODERMAL_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "GOBP_TROPHOBLAST_CELL_MIGRATION": "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst. [GOC:dph]", "GOBP_TRYPTOPHAN_METABOLIC_PROCESS": "", "GOBP_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. [GOC:dph, PMID:16269175]", "GOBP_TRYPTOPHAN_CATABOLIC_PROCESS_TO_KYNURENINE": "", "GOBP_TRYPTOPHAN_TRANSPORT": "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_TRUNK_SEGMENTATION": "", "GOBP_TUBE_LUMEN_CAVITATION": "The formation of a lumen by hollowing out a solid rod or cord. [GOC:dph]", "GOBP_TUBULIN_COMPLEX_ASSEMBLY": "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. [GOC:mah]", "GOBP_TUBE_FORMATION": "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. [GOC:bf]", "GOBP_TUBULIN_DEACETYLATION": "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:BHF, GOC:dph, GOC:tb]", "GOBP_TUBE_DEVELOPMENT": "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. [PMID:12526790]", "GOBP_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]", "GOBP_TYPE_B_PANCREATIC_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305]", "GOBP_TYPE_2_IMMUNE_RESPONSE": "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects. [GOC:add, ISBN:0781735149, PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518]", "GOBP_TYPE_B_PANCREATIC_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. [CL:0000169, GOC:dph]", "GOBP_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION": "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add]", "GOBP_TYPE_B_PANCREATIC_CELL_DIFFERENTIATION": "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. [CL:0000169, GOC:dph, PMID:11076772]", "GOBP_TUBE_MORPHOGENESIS": "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. [GOC:bf, PMID:14624839]", "GOBP_TYPE_B_PANCREATIC_CELL_PROLIFERATION": "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. [GOC:jl, GOC:yaf]", "GOBP_TYPE_II_HYPERSENSITIVITY": "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors. [GOC:add, ISBN:0781735149]", "GOBP_TYPE_III_INTERFERON_PRODUCTION": "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]", "GOBP_TYPE_II_INTERFERON_MEDIATED_SIGNALING_PATHWAY": "The series of molecular signals initiated by interferon-gamma binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. [GOC:add, GOC:dph, GOC:signaling, PMID:28901902]", "GOBP_TYPE_II_PNEUMOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. [GOC:dph, GOC:mtg_lung, ISBN:0721662544]", "GOBP_TYPE_II_INTERFERON_PRODUCTION": "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]", "GOBP_TYPE_I_PNEUMOCYTE_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. [GOC:dph, GOC:mtg_lung, ISBN:0721662544]", "GOBP_TYPE_I_INTERFERON_PRODUCTION": "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]", "GOBP_TYROSINE_CATABOLIC_PROCESS": "", "GOBP_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN": "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:10918594]", "GOBP_T_CELL_ACTIVATION_VIA_T_CELL_RECEPTOR_CONTACT_WITH_ANTIGEN_BOUND_TO_MHC_MOLECULE_ON_ANTIGEN_PRESENTING_CELL": "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_T_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION": "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, PMID:11417857, PMID:15120183]", "GOBP_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE": "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]", "GOBP_T_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "GOBP_T_CELL_ACTIVATION": "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]", "GOBP_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE": "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. [GOC:add, ISBN:0781735149]", "GOBP_T_CELL_CHEMOTAXIS": "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. [GOC:dph, GOC:tb]", "GOBP_T_CELL_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a T cell. [GOC:add, ISBN:0781735149]", "GOBP_T_CELL_EXTRAVASATION": "The migration of a T cell from the blood vessels into the surrounding tissue. [CL:0000084, GOC:BHF, GOC:mah]", "GOBP_T_CELL_DIFFERENTIATION_IN_THYMUS": "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. [GOC:add, ISBN:0781735149]", "GOBP_T_CELL_MEDIATED_IMMUNE_RESPONSE_TO_TUMOR_CELL": "An immune response mediated by a T cell triggered in response to the presence of a tumor cell. [GOC:add, ISBN:0781735149, PMID:16730260]", "GOBP_T_CELL_HOMEOSTASIS": "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:mgi_curators, ISBN:0781735149]", "GOBP_T_CELL_LINEAGE_COMMITMENT": "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. [GOC:add, ISBN:0781735149]", "GOBP_T_CELL_MEDIATED_CYTOTOXICITY": "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826]", "GOBP_T_CELL_DIFFERENTIATION": "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. [GO_REF:0000022, GOC:jid, GOC:mah]", "GOBP_T_CELL_MEDIATED_IMMUNITY": "Any process involved in the carrying out of an immune response by a T cell. [GO_REF:0000022, GOC:add, ISBN:0781735149]", "GOBP_T_CELL_MIGRATION": "The movement of a T cell within or between different tissues and organs of the body. [CL:0000084, GOC:BHF, GOC:mah]", "GOBP_T_CELL_PROLIFERATION_INVOLVED_IN_IMMUNE_RESPONSE": "", "GOBP_T_CELL_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. [GOC:add]", "GOBP_T_FOLLICULAR_HELPER_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell. [GOC:dph, PMID:21572431]", "GOBP_T_CELL_SELECTION": "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. [ISBN:0781735149, PMID:12414722]", "GOBP_T_CELL_TOLERANCE_INDUCTION": "A process involving any mechanism for tolerance induction in T cells. [GOC:jal, ISBN:0781735149, PMID:16551263]", "GOBP_T_HELPER_17_CELL_LINEAGE_COMMITMENT": "", "GOBP_T_CELL_PROLIFERATION": "The expansion of a T cell population by cell division. Follows T cell activation. [GOC:jl]", "GOBP_T_HELPER_17_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. [CL:0000899, GOC:BHF, GOC:ebc]", "GOBP_T_HELPER_1_CELL_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a T-helper 1 cell. [CL:0000545, GOC:BHF]", "GOBP_T_HELPER_17_TYPE_IMMUNE_RESPONSE": "An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22. [GOC:BHF, GOC:ebc]", "GOBP_T_HELPER_1_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. [CL:0000545, GOC:ebc]", "GOBP_T_HELPER_1_TYPE_IMMUNE_RESPONSE": "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. [GOC:add, ISBN:0781735149]", "GOBP_T_HELPER_2_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4. [CL:0000546, GOC:ebc]", "GOBP_T_TUBULE_ORGANIZATION": "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. [GOC:dph, GOC:jl, GOC:mah]", "GOBP_U2_TYPE_PRESPLICEOSOME_ASSEMBLY": "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome. [GO_REF:0000079, GOC:TermGenie, PMID:12374752]", "GOBP_T_HELPER_2_CELL_CYTOKINE_PRODUCTION": "Any process that contributes to cytokine production by a T-helper 2 cell. [CL:0000546, GOC:BHF]", "GOBP_T_HELPER_CELL_LINEAGE_COMMITMENT": "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes. [GOC:add, ISBN:0781735149]", "GOBP_U4_SNRNA_3_END_PROCESSING": "Any process involved in forming the mature 3' end of a U4 snRNA molecule. [GOC:mah]", "GOBP_UBIQUINONE_METABOLIC_PROCESS": "", "GOBP_UBIQUITIN_DEPENDENT_ENDOCYTOSIS": "Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded. [GOC:jp, GOC:mah, PMID:9409540]", "GOBP_UBIQUITIN_DEPENDENT_GLYCOPROTEIN_ERAD_PATHWAY": "", "GOBP_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_C_END_DEGRON_RULE_PATHWAY": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. [PMID:29775578, PMID:29779948]", "GOBP_UBIQUITIN_INDEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination. [PMID:22547407]", "GOBP_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY": "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. [GOC:jl, PMID:11511343]", "GOBP_UBIQUITIN_RECYCLING": "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates. [GOC:BHF, GOC:dph, GOC:tb, PMID:19410548]", "GOBP_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]", "GOBP_UDP_N_ACETYLGLUCOSAMINE_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai]", "GOBP_UDP_N_ACETYLGLUCOSAMINE_TRANSMEMBRANE_TRANSPORT": "The process in which UDP-N-acetylglucosamine is transported across a membrane. [PMID:10788474]", "GOBP_UDP_GLUCOSE_METABOLIC_PROCESS": "", "GOBP_UMP_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate. [GOC:go_curators]", "GOBP_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]", "GOBP_URATE_METABOLIC_PROCESS": "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. [ISBN:0198506732]", "GOBP_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. [GOC:mah]", "GOBP_URATE_TRANSPORT": "The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]", "GOBP_UREA_CYCLE": "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. [GOC:pde, GOC:vw, ISBN:0198506732]", "GOBP_UREA_TRANSPORT": "The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2. [GOC:ai, ISBN:0198506732]", "GOBP_URETERIC_BUD_FORMATION": "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud. [GOC:dph, PMID:16916378]", "GOBP_UREA_TRANSMEMBRANE_TRANSPORT": "The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]", "GOBP_URETERIC_BUD_ELONGATION": "The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated. [GOC:dph, PMID:16916378]", "GOBP_URETER_DEVELOPMENT": "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. [GOC:mtg_kidney_jan10]", "GOBP_URIDINE_TRANSMEMBRANE_TRANSPORT": "The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore. [GOC:go_curators]", "GOBP_URETER_MORPHOGENESIS": "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder. [GOC:mtg_kidney_jan10]", "GOBP_URINARY_TRACT_SMOOTH_MUSCLE_CONTRACTION": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra. [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551]", "GOBP_URINARY_BLADDER_SMOOTH_MUSCLE_CONTRACTION": "", "GOBP_UROGENITAL_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. [GOC:go_curators]", "GOBP_URONIC_ACID_METABOLIC_PROCESS": "", "GOBP_UTERINE_SMOOTH_MUSCLE_CONTRACTION": "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth. [GOC:sl]", "GOBP_UTERUS_MORPHOGENESIS": "The process in which anatomical structures of the uterus are generated and organized. [GOC:BHF, GOC:dph]", "GOBP_UTERUS_DEVELOPMENT": "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. [GOC:dph, GOC:ebc]", "GOBP_UTP_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. [ISBN:0198506732]", "GOBP_UV_DAMAGE_EXCISION_REPAIR": "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). [GOC:mah, PMID:9619100]", "GOBP_UTP_METABOLIC_PROCESS": "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. [GOC:go_curators]", "GOBP_UV_PROTECTION": "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. [GOC:jl, GOC:ml]", "GOBP_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX_ASSEMBLY": "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane. [GOC:BHF, GOC:mah]", "GOBP_VACUOLAR_ACIDIFICATION": "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. [GOC:jid]", "GOBP_VACUOLAR_TRANSMEMBRANE_TRANSPORT": "The process in which a solute is transported from one side of the vacuolar membrane to the other. [GOC:mah]", "GOBP_VACUOLAR_LOCALIZATION": "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. [PMID:26283797]", "GOBP_VACUOLE_FUSION": "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. [GOC:pr, GOC:vw, Wikipedia:Vacuole]", "GOBP_VAGINA_DEVELOPMENT": "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure. [GOC:dph, GOC:ebc]", "GOBP_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS": "Any apoptotic process in a vascular associated smooth muscle cell. [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]", "GOBP_VALINE_METABOLIC_PROCESS": "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. [GOC:ai]", "GOBP_VACUOLAR_TRANSPORT": "The directed movement of substances into, out of or within a vacuole. [GOC:ai]", "GOBP_VACUOLE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. [GOC:mah]", "GOBP_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_DEVELOPMENT": "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. [GOC:BHF]", "GOBP_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. [GOC:sl, PMID:16151017, PMID:18267954]", "GOBP_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_MIGRATION": "The orderly movement of a vascular associated smooth muscle cell from one site to another. [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]", "GOBP_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_PROLIFERATION": "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. [PMID:23246467]", "GOBP_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CONTRACTION": "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. [GOC:mtg_muscle, MA:0002718]", "GOBP_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_2_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-2 (VEGFR-2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:uh, PMID:12967471, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]", "GOBP_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION": "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:rl]", "GOBP_VASCULAR_ENDOTHELIAL_CELL_PROLIFERATION": "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774]", "GOBP_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]", "GOBP_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY": "The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:17470632]", "GOBP_VASCULAR_WOUND_HEALING": "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:BHF, GOC:dph]", "GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM": "A circulatory process that occurs at the level of the vasculature. [GOC:mtg_cardio]", "GOBP_VASCULAR_TRANSPORT": "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane. [GOC:sm]", "GOBP_VASCULOGENESIS_INVOLVED_IN_CORONARY_VASCULAR_MORPHOGENESIS": "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. [GOC:mtg_heart]", "GOBP_VASCULOGENESIS": "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. [PMID:8999798]", "GOBP_VASOCONSTRICTION": "A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. [GOC:pr, ISBN:0192800752]", "GOBP_VENOUS_BLOOD_VESSEL_DEVELOPMENT": "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. [GOC:dph, GOC:sdb_2009, GOC:tb]", "GOBP_VASODILATION": "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. [GOC:pr, ISBN:0192800981]", "GOBP_VENOUS_BLOOD_VESSEL_MORPHOGENESIS": "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. [GOC:dsf, PMID:16740480]", "GOBP_VENTRAL_MIDLINE_DEVELOPMENT": "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate. [GOC:bf, GOC:go_curators, PMID:12075342]", "GOBP_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION": "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]", "GOBP_VENTRAL_SPINAL_CORD_DEVELOPMENT": "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]", "GOBP_VASCULATURE_DEVELOPMENT": "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. [GOC:dph, UBERON:0002409]", "GOBP_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT": "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. [GOC:devbiol, GOC:mtg_muscle]", "GOBP_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "An action potential that occurs in a ventricular cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_VENTRICULAR_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION": "The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOBP_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. [GOC:devbiol, GOC:mtg_heart]", "GOBP_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT": "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS": "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. [GOC:devbiol]", "GOBP_VENTRICULAR_COMPACT_MYOCARDIUM_MORPHOGENESIS": "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized. [GOC:mtg_heart]", "GOBP_VENTRICULAR_SEPTUM_DEVELOPMENT": "The progression of the ventricular septum over time from its formation to the mature structure. [GOC:mtg_heart]", "GOBP_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS": "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. [GOC:mtg_heart]", "GOBP_VENTRICULAR_SYSTEM_DEVELOPMENT": "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_VENTRICULAR_SEPTUM_MORPHOGENESIS": "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. [GOC:dph]", "GOBP_VERY_LONG_CHAIN_FATTY_ACID_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. [PMID:7744868]", "GOBP_VERY_LONG_CHAIN_FATTY_ACID_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. [PMID:7744868]", "GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS": "The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. [GOC:hjd]", "GOBP_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY": "The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle. [GOC:BHF, GOC:mah]", "GOBP_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE": "The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:rl]", "GOBP_VESICLE_BUDDING_FROM_MEMBRANE": "The evagination of a membrane, resulting in formation of a vesicle. [GOC:jid, GOC:tb]", "GOBP_VESICLE_CARGO_LOADING": "The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle. [GOC:bf, GOC:lb]", "GOBP_VESICLE_COATING": "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. [GOC:jid]", "GOBP_VESICLE_CYTOSKELETAL_TRAFFICKING": "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. [GOC:ecd, GOC:rl]", "GOBP_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS": "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]", "GOBP_VESICLE_DOCKING": "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. [GOC:ai, GOC:jid]", "GOBP_VESICLE_FUSION_WITH_GOLGI_APPARATUS": "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. [GOC:jid]", "GOBP_VESICLE_MEDIATED_CHOLESTEROL_TRANSPORT": "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles. [GOC:ascb_2009, GOC:dph, GOC:tb]", "GOBP_VESICLE_FUSION_TO_PLASMA_MEMBRANE": "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]", "GOBP_VESICLE_LOCALIZATION": "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. [GOC:ai]", "GOBP_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS": "A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. [GOC:dos, PMID:10930469]", "GOBP_VESICLE_MEDIATED_TRANSPORT_IN_SYNAPSE": "Any vesicle-mediated transport that occurs in a synapse. [GOC:dos]", "GOBP_VESICLE_TARGETING": "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. [GOC:mah, PMID:17335816]", "GOBP_VESICLE_MEDIATED_TRANSPORT_TO_THE_PLASMA_MEMBRANE": "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. [GOC:dos]", "GOBP_VESICLE_TARGETING_TO_FROM_OR_WITHIN_GOLGI": "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]", "GOBP_VESICLE_TARGETING_ROUGH_ER_TO_CIS_GOLGI": "The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi. [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]", "GOBP_VESICLE_MEDIATED_TRANSPORT": "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. [GOC:ai, GOC:mah, ISBN:08789310662000]", "GOBP_VESICLE_TETHERING_INVOLVED_IN_EXOCYTOSIS": "The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]", "GOBP_VESICLE_TETHERING": "The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion. [PMID:27243008]", "GOBP_VESICLE_ORGANIZATION": "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. [GOC:mah]", "GOBP_VESICLE_TETHERING_TO_GOLGI": "The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion. [PMID:27243008]", "GOBP_VESICLE_TRANSPORT_ALONG_ACTIN_FILAMENT": "Movement of a vesicle along an actin filament, mediated by motor proteins. [GOC:mah]", "GOBP_VESICLE_UNCOATING": "A protein depolymerization process that results in the disassembly of vesicle coat proteins. [GOC:mah]", "GOBP_VESTIBULOCOCHLEAR_NERVE_DEVELOPMENT": "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_VESICLE_TRANSPORT_ALONG_MICROTUBULE": "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. [GOC:ecd, GOC:rl]", "GOBP_VESTIBULOCOCHLEAR_NERVE_FORMATION": "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_VIRAL_BUDDING": "A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. [ISBN:0781718325, VZ:1947]", "GOBP_VESTIBULOCOCHLEAR_NERVE_MORPHOGENESIS": "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]", "GOBP_VIRAL_GENOME_REPLICATION": "Any process involved directly in viral genome replication, including viral nucleotide metabolism. [ISBN:0781702534]", "GOBP_VIRAL_GENE_EXPRESSION": "A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation. [GOC:bf, GOC:jl, ISBN:0121585336]", "GOBP_VIRAL_RELEASE_FROM_HOST_CELL": "The dissemination of mature viral particles from a host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane. [GOC:jl]", "GOBP_VIRAL_PROTEIN_PROCESSING": "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein. [GOC:bf, GOC:jl, ISBN:0781702534]", "GOBP_VIRAL_LIFE_CYCLE": "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. [ISBN:1555811272]", "GOBP_VIRAL_RNA_GENOME_REPLICATION": "The replication of a viral RNA genome. [GOC:bf, GOC:jl]", "GOBP_VIRAL_TRANSCRIPTION": "The process by which a viral genome, or part of a viral genome, is transcribed within the host cell. [GOC:jl, ISBN:0781702534]", "GOBP_VIRAL_PROCESS": "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. [GOC:bf, GOC:jl, GOC:mah]", "GOBP_VIRAL_TRANSLATIONAL_TERMINATION_REINITIATION": "A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF. [GOC:bf, GOC:ch, GOC:jl, PMID:18631147, PMID:18824510, VZ:858]", "GOBP_VIRAL_TRANSLATION": "A process by which viral mRNA is translated into viral protein, using the host cellular machinery. [GOC:bf, GOC:jl, ISBN:0781702534]", "GOBP_VITAMIN_B6_METABOLIC_PROCESS": "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. [GOC:jl, PMID:30037155, PMID:30671974]", "GOBP_VISUAL_BEHAVIOR": "The behavior of an organism in response to a visual stimulus. [GOC:jid, GOC:pr]", "GOBP_VIRION_ASSEMBLY": "A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. [ISBN:0121585336]", "GOBP_VITAMIN_A_METABOLIC_PROCESS": "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene. [GOC:jl, PMID:1503811]", "GOBP_VITAMIN_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body, carried out by individual cells. [GOC:ai]", "GOBP_VITAMIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:go_curators, ISBN:0198506732]", "GOBP_VITAMIN_D3_METABOLIC_PROCESS": "The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol. [GOC:BHF, GOC:mah]", "GOBP_VITAMIN_D_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]", "GOBP_VITAMIN_D_METABOLIC_PROCESS": "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]", "GOBP_VITAMIN_D_RECEPTOR_SIGNALING_PATHWAY": "A nuclear receptor-mediated signaling pathway initiated by vitamin D binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, PMID:12637589]", "GOBP_VITAMIN_E_METABOLIC_PROCESS": "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. [GOC:jl, ISBN:0198506732]", "GOBP_VITAMIN_TRANSMEMBRANE_TRANSPORT": "The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:bf]", "GOBP_VITAMIN_K_METABOLIC_PROCESS": "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule. [GOC:jl, https://en.wikipedia.org/wiki/Vitamin_K, PMID:24489112]", "GOBP_VITAMIN_METABOLIC_PROCESS": "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. [GOC:ai]", "GOBP_VOCALIZATION_BEHAVIOR": "The behavior in which an organism produces sounds by a mechanism involving its respiratory system. [GOC:mah]", "GOBP_VOLUNTARY_SKELETAL_MUSCLE_CONTRACTION": "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control. [GOC:mtg_cardio, GOC:mtg_muscle]", "GOBP_VOLUNTARY_MUSCULOSKELETAL_MOVEMENT": "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will. [GOC:dph]", "GOBP_V_D_J_RECOMBINATION": "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). [GOC:add, ISBN:0781700221, ISBN:0781735149]", "GOBP_VITAMIN_TRANSPORT": "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]", "GOBP_WALKING_BEHAVIOR": "The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. [GOC:tb]", "GOBP_WATER_SOLUBLE_VITAMIN_BIOSYNTHETIC_PROCESS": "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water. [GOC:jl]", "GOBP_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS": "", "GOBP_WATER_TRANSPORT": "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_WHITE_FAT_CELL_DIFFERENTIATION": "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. [PMID:12508945]", "GOBP_WNT_PROTEIN_SECRETION": "The controlled release of a Wnt protein from a cell. [GOC:bf, PMID:19223472]", "GOBP_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY": "A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface of a target cell leads to an increase in intracellular calcium and activation of protein kinase C (PKC). [PMID:11532397, PMID:37804416]", "GOBP_WOUND_HEALING_INVOLVED_IN_INFLAMMATORY_RESPONSE": "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response. [GOC:jal, ISBN:0721601871]", "GOBP_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY": "A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton. [PMID:11532397, PMID:25349257, PMID:28293032, PMID:37804416]", "GOBP_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS": "The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. [GOC:bf, PMID:15269788]", "GOBP_WNT_SIGNALING_PATHWAY": "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397]", "GOBP_WYBUTOSINE_METABOLIC_PROCESS": "", "GOBP_XENOBIOTIC_EXPORT_FROM_CELL": "The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]", "GOBP_XENOBIOTIC_CATABOLIC_PROCESS": "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organism exposed to it, carried out by individual cells. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]", "GOBP_XENOBIOTIC_GLUCURONIDATION": "", "GOBP_WOUND_HEALING": "The series of events that restore integrity to a damaged tissue, following an injury. [GOC:bf, PMID:15269788]", "GOBP_XENOBIOTIC_METABOLIC_PROCESS": "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]", "GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER": "The directed movement of a xenobiotic through the blood-brain barrier. [PMID:25053619]", "GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT": "The process in which a xenobiotic, a compound foreign to the organism exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:ai, GOC:bf, GOC:krc]", "GOBP_XENOPHAGY": "The selective degradation of intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) by macroautophagy. [GOC:autophagy, GOC:pad, GOC:PARL, PMID:19802565, PMID:20159618, PMID:25497060]", "GOBP_XMP_METABOLIC_PROCESS": "The chemical reactions and pathways involving XMP, xanthosine monophosphate. [GOC:yaf]", "GOBP_XENOBIOTIC_TRANSPORT": "The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]", "GOBP_ZINC_ION_IMPORT_ACROSS_PLASMA_MEMBRANE": "The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:vw, PMID:18637840]", "GOBP_ZINC_ION_IMPORT_INTO_ORGANELLE": "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into the organelle. [PMID:29529046]", "GOBP_XYLULOSE_5_PHOSPHATE_METABOLIC_PROCESS": "", "GOBP_ZINC_ION_TRANSPORT": "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]", "GOBP_ZYGOTIC_DETERMINATION_OF_ANTERIOR_POSTERIOR_AXIS_EMBRYO": "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]", "GOBP_ZYMOGEN_INHIBITION": "", "GOCC_90S_PRERIBOSOME": "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]", "GOBP_ZYMOGEN_ACTIVATION": "The proteolytic processing of an inactive enzyme to an active form. [GOC:hjd]", "GOCC_3M_COMPLEX": "A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity. [PMID:24793695, PMID:24793696]", "GOCC_9PLUS0_MOTILE_CILIUM": "A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). [GOC:cilia, PMID:10330409, PMID:22118931]", "GOCC_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX": "A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]", "GOCC_9PLUS0_NON_MOTILE_CILIUM": "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). [GOC:cilia, PMID:22118931]", "GOCC_ACROSOMAL_MEMBRANE": "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. [GOC:dph]", "GOCC_9PLUS2_MOTILE_CILIUM": "A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme). [GOC:cilia, PMID:22118931]", "GOCC_ACETYLTRANSFERASE_COMPLEX": "A protein complex which is capable of acetyltransferase activity. [GOC:bhm, GOC:TermGenie, PMID:8077207]", "GOCC_ACTIN_BASED_CELL_PROJECTION": "A cell projection supported by an assembly of actin filaments, and which lacks microtubules. [PMID:15661519]", "GOCC_ACTIN_FILAMENT": "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. [GOC:mah, ISBN:0198506732, PMID:10666339]", "GOCC_ACTIVIN_RECEPTOR_COMPLEX": "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed. [PMID:8307945, PMID:8622651]", "GOCC_ACROSOMAL_VESICLE": "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. [ISBN:0124325653, ISBN:0198506732]", "GOCC_ACTIN_FILAMENT_BUNDLE": "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. [GOC:mah]", "GOCC_AGGRESOME": "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. [PMID:11121744]", "GOCC_ACTOMYOSIN": "Any complex of actin, myosin, and accessory proteins. [GOC:go_curators]", "GOCC_ALPHA_BETA_T_CELL_RECEPTOR_COMPLEX": "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein. [GOC:mah, ISBN:0781735149]", "GOCC_ADHERENS_JUNCTION": "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]", "GOCC_ACTIN_CYTOSKELETON": "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]", "GOCC_ALPHA_KETOACID_DEHYDROGENASE_COMPLEX": "A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present. [GOC:mah, PMID:10745006]", "GOCC_ALPHA_DNA_POLYMERASE_PRIMASE_COMPLEX": "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. [GOC:mah, PMID:11395402, PMID:26975377]", "GOCC_AMINOACYL_TRNA_SYNTHETASE_MULTIENZYME_COMPLEX": "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates. [GOC:jl, PMID:16169847]", "GOCC_AMPA_GLUTAMATE_RECEPTOR_COMPLEX": "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. [GOC:ef]", "GOCC_ALVEOLAR_LAMELLAR_BODY": "A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. [GOC:cjm, Wikipedia:Lamellar_granule]", "GOCC_ANAPHASE_PROMOTING_COMPLEX": "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]", "GOCC_ANNULATE_LAMELLAE": "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER. [PMID:12631728]", "GOCC_AMPHISOME": "Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes. [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]", "GOCC_ANKYRIN_1_COMPLEX": "A complex composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1, that functions in the stability and shape of the erythrocyte membrane in human. [PMID:35835865]", "GOCC_APICAL_DENDRITE": "A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. [NIF_Subcellular:sao273773228]", "GOCC_APICAL_CORTEX": "The region that lies just beneath the plasma membrane on the apical edge of a cell. [GOC:bf]", "GOCC_APICOLATERAL_PLASMA_MEMBRANE": "The apical end of the lateral plasma membrane of epithelial cells. [GOC:hb]", "GOCC_APOLIPOPROTEIN_B_MRNA_EDITING_ENZYME_COMPLEX": "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP). [PMID:10781591, PMID:12683974]", "GOCC_ANCHORING_JUNCTION": "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. [ISBN:0815332181]", "GOCC_APICAL_JUNCTION_COMPLEX": "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]", "GOCC_AP_2_ADAPTOR_COMPLEX": "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426]", "GOCC_AP_1_ADAPTOR_COMPLEX": "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). [GOC:mah, PMID:10611976, PMID:21097499]", "GOCC_AP_3_ADAPTOR_COMPLEX": "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). [GOC:mah, PMID:10611976, PMID:21097499]", "GOCC_APICAL_PART_OF_CELL": "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. [GOC:mah, ISBN:0815316194]", "GOCC_ARP2_3_PROTEIN_COMPLEX": "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. [GOC:jl, GOC:vw, PMID:12479800]", "GOCC_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX": "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). [GOC:mah, PMID:10611976, PMID:15473838]", "GOCC_ARYL_HYDROCARBON_RECEPTOR_COMPLEX": "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR. [GOC:mah, PMID:7598497]", "GOCC_ASTER": "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores. [GOC:clt]", "GOCC_ASTROCYTE_END_FOOT": "Terminal process of astrocyte abutting non-neuronal surfaces in the brain. [NIF_Subcellular:sao388182739]", "GOCC_ASYMMETRIC_GLUTAMATERGIC_EXCITATORY_SYNAPSE": "A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials. [GOC:dos]", "GOCC_ASTROCYTE_PROJECTION": "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. [NIF_Subcellular:sao1630537580]", "GOCC_ATG12_ATG5_ATG16_COMPLEX": "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p. [GOC:rb, PMID:17986448]", "GOCC_ATAC_COMPLEX": "A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation. [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424]", "GOCC_ATG1_ULK1_KINASE_COMPLEX": "A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]", "GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX": "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]", "GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX": "A transmembrane protein complex that functions in ATPase dependent active transport across a membrane. [GOC:dos]", "GOCC_ATPASE_COMPLEX": "A protein complex which is capable of ATPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181]", "GOCC_AUTOLYSOSOME": "A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome or amphisome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases. [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921, PMID:24657946]", "GOCC_AXOLEMMA": "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. [PMID:9527135]", "GOCC_AUTOPHAGOSOME": "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. [GOC:autophagy, ISBN:0198547684, PMID:11099404]", "GOCC_AXONAL_GROWTH_CONE": "The migrating motile tip of a growing nerve cell axon. [GOC:jl, NIF_Subcellular:sao203987954]", "GOCC_AUTOPHAGOSOME_MEMBRANE": "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. [GOC:autophagy, GOC:isa_complete]", "GOCC_AXONEMAL_A_TUBULE_INNER_SHEATH": "A structural network of microtubule inner proteins (MIPs) located inside the lumen of the A tubule of the axonemal microtubule doublet that helps stabilize the A tubule. [GOC:krc, PMID:29430673, PMID:37295417]", "GOCC_AXONEMAL_B_TUBULE_INNER_SHEATH": "A structural network of microtubule inner proteins (MIPs) located inside the lumen of the B tubule of the axonemal microtubule doublet that helps stabilize the B tubule. [GOC:krc, PMID:29430673, PMID:37295417]", "GOCC_AXONEMAL_DYNEIN_COMPLEX": "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]", "GOCC_AXONEMAL_OUTER_DOUBLET": "", "GOCC_AXONEMAL_MICROTUBULE": "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. [GOC:cilia, ISBN:0815316194]", "GOCC_AXON_HILLOCK": "Portion of the neuronal cell soma from which the axon originates. [GOC:nln]", "GOCC_AXON_CYTOPLASM": "Any cytoplasm that is part of a axon. [GO_REF:0000064, GOC:TermGenie, PMID:18667152]", "GOCC_AXON_INITIAL_SEGMENT": "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097]", "GOCC_AXON": "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]", "GOCC_AZUROPHIL_GRANULE_LUMEN": "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]", "GOCC_AZUROPHIL_GRANULE": "Primary lysosomal granule readily stainable with a Romanowsky stain. [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule]", "GOCC_AZUROPHIL_GRANULE_MEMBRANE": "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]", "GOCC_A_BAND": "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. [ISBN:0321204131]", "GOCC_BARR_BODY": "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. [GOC:hjd, GOC:mr, NIF_Subcellular:sao1571698684]", "GOCC_BASAL_CORTEX": "The region that lies just beneath the plasma membrane on the basal edge of a cell. [GOC:bf]", "GOCC_BASAL_DENDRITE": "A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon. [GOC:aruk, GOC:bc, NIF_Subcellular:sao1079900774, PMID:17046728, PMID:22683681]", "GOCC_BASEMENT_MEMBRANE_COLLAGEN_TRIMER": "", "GOCC_BASEMENT_MEMBRANE": "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. [PMID:22505934, PMID:33605520, PMID:39223427]", "GOCC_BBAF_COMPLEX": "A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180. [GOC:bhm, PMID:12368262, PMID:12620226, PMID:15525990, PMID:17640523, PMID:17920018, PMID:8804307, PMID:8895581]", "GOCC_BCL_2_FAMILY_PROTEIN_COMPLEX": "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. [GOC:so, PMID:14634621]", "GOCC_BBSOME": "A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B. [GOC:BHF, GOC:cilia, PMID:15231740, PMID:17574030, PMID:26498262]", "GOCC_BASOLATERAL_PLASMA_MEMBRANE": "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]", "GOCC_BASAL_PART_OF_CELL": "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. [GOC:mah, ISBN:0815316194]", "GOCC_BETA_CATENIN_TCF_COMPLEX": "A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]", "GOCC_BETA_CATENIN_DESTRUCTION_COMPLEX": "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. [PMID:14600025]", "GOCC_BLEB": "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]", "GOCC_BLOC_1_COMPLEX": "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. [PMID:15102850]", "GOCC_BLOC_COMPLEX": "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. [PMID:15102850, PMID:15261680]", "GOCC_BLOOD_MICROPARTICLE": "A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. [GOC:BHF, GOC:mah, PMID:16373184]", "GOCC_BOX_C_D_RNP_COMPLEX": "A ribonucleoprotein complex consisting of a box C/D type snRNA and three (Archaea) or four (Eukaryotes) core proteins that have diverse functions, including site-specific methylation of rRNA and processing rRNA. [PMID:28505386, PMID:30254138]", "GOCC_BORC_COMPLEX": "A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors. [GOC:dos, GOC:li, PMID:25898167]", "GOCC_BOX_H_ACA_RNP_COMPLEX": "A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex. [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:krc, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365, PMID:25590339]", "GOCC_BOX_H_ACA_TELOMERASE_RNP_COMPLEX": "A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell. [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:22527283]", "GOCC_BRAHMA_COMPLEX": "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof. [GOC:bhm, PMID:10809665, PMID:12482982]", "GOCC_BRCA1_A_COMPLEX": "A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. [GOC:mah, PMID:19261749]", "GOCC_BRISC_COMPLEX": "A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains. [GOC:mah, PMID:19214193]", "GOCC_BRCA1_C_COMPLEX": "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint. [GOC:mah, PMID:15485915, PMID:16391231]", "GOCC_B_CELL_RECEPTOR_COMPLEX": "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. [GOC:add, ISBN:0781735149]", "GOCC_B_WICH_COMPLEX": "A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself. [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184]", "GOCC_BRUSH_BORDER": "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. [GOC:sl, ISBN:0815316194]", "GOCC_BRUSH_BORDER_MEMBRANE": "The portion of the plasma membrane surrounding the brush border. [GOC:mah]", "GOCC_CALCINEURIN_COMPLEX": "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. [PMID:26794871]", "GOCC_CAJAL_BODY": "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]", "GOCC_CALCITONIN_FAMILY_RECEPTOR_COMPLEX": "A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416]", "GOCC_CALYX_OF_HELD": "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. [NIF_Subcellular:sao1684283879, PMID:11823805]", "GOCC_CALCIUM_AND_CALMODULIN_DEPENDENT_PROTEIN_KINASE_COMPLEX": "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins. [PMID:20668654]", "GOCC_CALCIUM_CHANNEL_COMPLEX": "An ion channel complex through which calcium ions pass. [GOC:mah]", "GOCC_CARDIAC_MYOFIBRIL": "A cardiac myofibril is a myofibril specific to cardiac muscle cells. [GOC:cjm, GOC:devbiol]", "GOCC_CANONICAL_INFLAMMASOME_COMPLEX": "A cytosolic protein complex that is capable of activating caspase-1. [GOC:dph, PMID:17599095]", "GOCC_CAMP_DEPENDENT_PROTEIN_KINASE_COMPLEX": "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. [PMID:18178622]", "GOCC_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX": "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. [PMID:15047695, PMID:16721054, PMID:17079683]", "GOCC_CASPASE_COMPLEX": "A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes. [GOC:cna, GOC:mtg_apoptosis, PMID:15569692]", "GOCC_CATALYTIC_COMPLEX": "", "GOCC_CATALYTIC_STEP_1_SPLICEOSOME": "A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]", "GOCC_CATALYTIC_STEP_2_SPLICEOSOME": "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]", "GOCC_CATENIN_COMPLEX": "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. [ISBN:0198599323]", "GOCC_CATION_TRANSPORTING_ATPASE_COMPLEX": "", "GOCC_CATSPER_COMPLEX": "A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits. [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039]", "GOCC_CATION_CHANNEL_COMPLEX": "An ion channel complex through which cations pass. [GOC:mah]", "GOCC_CBM_COMPLEX": "A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation. [PMID:12909454, PMID:30467369]", "GOCC_CAVEOLA": "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198]", "GOCC_CCAAT_BINDING_FACTOR_COMPLEX": "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. [GOC:bhm, PMID:7828851]", "GOCC_CCR4_NOT_COMPLEX": "The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]", "GOCC_CCR4_NOT_CORE_COMPLEX": "The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. [GOC:sart, PMID:11113136]", "GOCC_CD40_RECEPTOR_COMPLEX": "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. [GOC:BHF, PMID:20614026, PMID:9221764]", "GOCC_CD95_DEATH_INDUCING_SIGNALING_COMPLEX": "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor. [PMID:12628743, PMID:12655293]", "GOCC_CDC73_PAF1_COMPLEX": "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. [PMID:11884586]", "GOCC_CELL_BODY_FIBER": "A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches. [GOC:dos, GOC:mah]", "GOCC_CELL_BODY_MEMBRANE": "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections. [GOC:ecd]", "GOCC_CELL_CELL_CONTACT_ZONE": "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. [NIF_Subcellular:sao1299635018]", "GOCC_CELL_BODY": "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. [GOC:go_curators]", "GOCC_CELL_CORTEX_REGION": "The complete extent of cell cortex that underlies some some region of the plasma membrane. [GOC:dos]", "GOCC_CELL_DIVISION_SITE": "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]", "GOCC_CELL_POLE": "Either of two different areas at opposite ends of an axis of a cell. [GOC:dph]", "GOCC_CELL_CORTEX": "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. [GOC:mah, ISBN:0815316194]", "GOCC_CELL_CELL_JUNCTION": "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]", "GOCC_CELL_LEADING_EDGE": "The area of a motile cell closest to the direction of movement. [GOC:pg]", "GOCC_CELL_TIP": "The region at the end of the longest axis of a cylindrical or elongated cell. [GOC:ai, GOC:mah]", "GOCC_CENTRAL_ELEMENT": "A structural unit of the synaptonemal complex found between the lateral elements. [GOC:elh]", "GOCC_CELL_PROJECTION_MEMBRANE": "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. [GOC:krc, GOC:mah]", "GOCC_CELL_TRAILING_EDGE": "The area of a motile cell opposite to the direction of movement. [GOC:pg]", "GOCC_CELL_SUBSTRATE_JUNCTION": "A cell junction that forms a connection between a cell and the extracellular matrix. [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]", "GOCC_CENTRIOLAR_SUBDISTAL_APPENDAGE": "A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68. [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092]", "GOCC_CENTRIOLAR_SATELLITE": "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. [GOC:BHF, PMID:10579718, PMID:12403812]", "GOCC_CELL_SURFACE": "The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]", "GOCC_CENTRIOLE": "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. [ISBN:0198547684]", "GOCC_CEREBELLAR_CLIMBING_FIBER_TO_PURKINJE_CELL_SYNAPSE": "A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. [GOC:aruk, GOC:bc, PMID:19597563, PMID:23811844, PMID:5044254]", "GOCC_CHECKPOINT_CLAMP_COMPLEX": "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. [PMID:12531008]", "GOCC_CEREBELLAR_MOSSY_FIBER": "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations. [NIF_Subcellular:nlx_subcell_20090209]", "GOCC_CHAPERONIN_CONTAINING_T_COMPLEX": "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor. [GOC:sgd_curators, PMID:11580267]", "GOCC_CHITOSOME": "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum. [ISBN:0198506732, PMID:8970154]", "GOCC_CENTROSOME": "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]", "GOCC_CHLORIDE_CHANNEL_COMPLEX": "An ion channel complex through which chloride ions pass. [GOC:mah]", "GOCC_CHOLINERGIC_SYNAPSE": "A synapse that uses acetylcholine as a neurotransmitter. [GOC:dos]", "GOCC_CHROMAFFIN_GRANULE": "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. [GOC:jl, PMID:19158310, PMID:1961743]", "GOCC_CHROMAFFIN_GRANULE_MEMBRANE": "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. [GOC:jl]", "GOCC_CHROMATIN_SILENCING_COMPLEX": "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing. [GOC:mah]", "GOCC_CHROMOCENTER": "A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure. [PMID:12384572, PMID:15053486, PMID:16831888]", "GOCC_CHROMATOID_BODY": "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). [PMID:17183363]", "GOCC_CHROMOSOME_CENTROMERIC_CORE_DOMAIN": "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it. [GOC:mah, GOC:vw]", "GOCC_CHROMOSOME_PASSENGER_COMPLEX": "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. [GOC:vw, PMID:16824200, PMID:19570910]", "GOCC_CHROMOSOME_TELOMERIC_REPEAT_REGION": "A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop. [PMID:11352055, PMID:30208292]", "GOCC_CHROMOSOMAL_REGION": "Any subdivision of a chromosome along its length. [GOC:dos]", "GOCC_CHYLOMICRON": "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. [GOC:jl, GOC:rl, PMID:10580165]", "GOCC_CHROMOSOME_CENTROMERIC_REGION": "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]", "GOCC_CIA_COMPLEX": "", "GOCC_CHROMOSOME_TELOMERIC_REGION": "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh]", "GOCC_CILIARY_BASE": "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. [GOC:cilia, GOC:krc, PMID:22653444]", "GOCC_CILIARY_PLASM": "", "GOCC_CILIARY_BASAL_BODY": "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. [GOC:cilia, GOC:clt, PMID:21750193]", "GOCC_CILIARY_MEMBRANE": "The portion of the plasma membrane surrounding a cilium. [GOC:cilia, GOC:dph, GOC:rph]", "GOCC_CILIARY_ROOTLET": "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm. [GOC:cilia, PMID:12427867]", "GOCC_CILIARY_TIP": "Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. [GOC:cilia, PMID:23970417]", "GOCC_CILIARY_TRANSITION_FIBER": "A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium). [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827]", "GOCC_CILIARY_TRANSITION_ZONE": "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. [GOC:cilia, GOC:kmv, PMID:21422230]", "GOCC_CIS_GOLGI_NETWORK": "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. [ISBN:0198506732, ISBN:0815316194, PMID:23543640, PMID:9695800]", "GOCC_CIS_GOLGI_NETWORK_MEMBRANE": "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network. [GOC:mah]", "GOCC_CLATHRIN_ADAPTOR_COMPLEX": "A membrane coat adaptor complex that links clathrin to a membrane. [GOC:mah]", "GOCC_CKM_COMPLEX": "Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8. [GOC:bhm, PMID:12200444]", "GOCC_CLATHRIN_COAT": "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. [GOC:mah, PMID:11252894, PMID:9531549]", "GOCC_CILIUM": "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]", "GOCC_CLATHRIN_COATED_ENDOCYTIC_VESICLE": "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. [GOC:go_curators]", "GOCC_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE": "The lipid bilayer surrounding a clathrin-coated endocytic vesicle. [GOC:mah]", "GOCC_CLATHRIN_COATED_PIT": "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]", "GOCC_CLATHRIN_COMPLEX": "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. [GOC:mah, PMID:16493411]", "GOCC_CLATHRIN_SCULPTED_GAMMA_AMINOBUTYRIC_ACID_TRANSPORT_VESICLE": "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle. [GOC:dph]", "GOCC_CLATHRIN_COAT_OF_COATED_PIT": "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. [GOC:mah]", "GOCC_CLATHRIN_COATED_VESICLE": "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. [GOC:mah, PMID:11252894]", "GOCC_CLATHRIN_COATED_VESICLE_MEMBRANE": "The lipid bilayer surrounding a clathrin-coated vesicle. [GOC:mah]", "GOCC_CLATHRIN_SCULPTED_MONOAMINE_TRANSPORT_VESICLE": "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines. [GOC:mg2]", "GOCC_CLATHRIN_SCULPTED_VESICLE": "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. [GOC:dph]", "GOCC_CLATHRIN_VESICLE_COAT": "A clathrin coat found on a vesicle. [GOC:mah]", "GOCC_CLEAVAGE_FURROW": "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm. [GOC:vw, ISBN:0805319409]", "GOCC_CLOCK_BMAL_TRANSCRIPTION_COMPLEX": "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms. [GOC:bhm, PMID:23229515]", "GOCC_CMG_COMPLEX": "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. [GOC:rb, PMID:19228417]", "GOCC_COHESIN_COMPLEX": "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]", "GOCC_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS": "A cell part consisting of multiple, closely packed actin-based cell projections. [GOC:dos]", "GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX": "", "GOCC_COATED_VESICLE": "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. [ISBN:0815316194]", "GOCC_COATED_VESICLE_MEMBRANE": "The lipid bilayer surrounding a coated vesicle. [GOC:mah]", "GOCC_COLLAGEN_TRIMER": "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. [GOC:dos, GOC:mah, PMID:19693541, PMID:21421911]", "GOCC_COLLAGEN_TYPE_IV_TRIMER": "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. [PMID:19693541, PMID:21421911]", "GOCC_COMMITMENT_COMPLEX": "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. [GOC:krc, ISBN:0879695897, PMID:9150140]", "GOCC_COMPACT_MYELIN": "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. [GOC:dgh, NIF_Subcellular:sao1123256993]", "GOCC_COMPLEX_OF_COLLAGEN_TRIMERS": "A complex of collagen trimers such as a fibril or collagen network. [GOC:dos]", "GOCC_CONDENSIN_COMPLEX": "A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis. [GOC:elh, PMID:17268547, PMID:21795393]", "GOCC_CONDENSED_CHROMOSOME": "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. [GOC:elh]", "GOCC_CONDENSED_NUCLEAR_CHROMOSOME": "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. [GOC:elh]", "GOCC_CONDENSED_CHROMOSOME_CENTROMERIC_REGION": "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. [GOC:elh, GOC:kmv]", "GOCC_CONNEXIN_COMPLEX": "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. [PMID:11146276]", "GOCC_CONE_PHOTORECEPTOR_OUTER_SEGMENT": "The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]", "GOCC_CONTRACTILE_RING": "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles. [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]", "GOCC_COP9_SIGNALOSOME": "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. [PMID:11019806, PMID:12186635, PMID:14570571]", "GOCC_CONTRACTILE_MUSCLE_FIBER": "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. [GOC:go_curators, ISBN:0815316194]", "GOCC_COPII_COATED_ER_TO_GOLGI_TRANSPORT_VESICLE": "A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport). [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]", "GOCC_COPI_COATED_VESICLE_MEMBRANE": "The lipid bilayer surrounding a COPI-coated vesicle. [GOC:mah]", "GOCC_COPII_VESICLE_COAT": "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]", "GOCC_COPI_VESICLE_COAT": "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. [GOC:mah, PMID:11252894]", "GOCC_COPI_COATED_VESICLE": "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. [GOC:mah, PMID:11252894]", "GOCC_CORE_MEDIATOR_COMPLEX": "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. [PMID:11454195, PMID:16168358, PMID:17870225]", "GOCC_CORNIFIED_ENVELOPE": "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139]", "GOCC_CORTICAL_ACTIN_CYTOSKELETON": "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. [GOC:mah]", "GOCC_CORTICAL_GRANULE": "A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy. [GOC:dph]", "GOCC_CORTICAL_CYTOSKELETON": "The portion of the cytoskeleton that lies just beneath the plasma membrane. [GOC:mah]", "GOCC_CORTICAL_ENDOPLASMIC_RETICULUM": "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. [GOC:se, PMID:10931860, PMID:17686782]", "GOCC_COSTAMERE": "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378]", "GOCC_CORVET_COMPLEX": "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p. [PMID:17488625]", "GOCC_CTF18_RFC_LIKE_COMPLEX": "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. [PMID:14614842]", "GOCC_CRD_MEDIATED_MRNA_STABILITY_COMPLEX": "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9. [GOC:mah, PMID:19029303]", "GOCC_CUL2_RING_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. [PMID:15571813, PMID:15688063]", "GOCC_CUL4B_RING_E3_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits. [PMID:15571813, PMID:15688063]", "GOCC_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. [PMID:15571813, PMID:15688063]", "GOCC_CUL4A_RING_E3_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. [PMID:15571813, PMID:15688063]", "GOCC_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. [PMID:16792691, PMID:18223036, PMID:18552200]", "GOCC_CUL5_RING_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. [PMID:15571813, PMID:15688063]", "GOCC_CUTICULAR_PLATE": "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted. [PMID:12485990, PMID:2592408, PMID:8071151]", "GOCC_CYCLIN_CDK_POSITIVE_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX": "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473]", "GOCC_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX": "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261]", "GOCC_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX": "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. [PMID:15571813, PMID:15688063]", "GOCC_CYTOLYTIC_GRANULE": "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. [GOC:jl, PMID:11052265, PMID:12766758]", "GOCC_CYTOPLASMIC_DYNEIN_COMPLEX": "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]", "GOCC_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX": "A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. [PMID:17174896, PMID:20531386, PMID:26726035]", "GOCC_CYTOCHROME_COMPLEX": "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. [GOC:mah]", "GOCC_CYTOPLASMIC_SIDE_OF_ENDOSOME_MEMBRANE": "The side (leaflet) of the endosome membrane that faces the cytoplasm. [GOC:lr]", "GOCC_CYTOPLASMIC_SIDE_OF_ENDOPLASMIC_RETICULUM_MEMBRANE": "The side (leaflet) of the plasma membrane that faces the cytoplasm. [GOC:ab, GOC:dos]", "GOCC_CYTOPLASMIC_MICROTUBULE": "Any microtubule in the cytoplasm of a cell. [GOC:mah]", "GOCC_CYTOPLASMIC_SIDE_OF_LYSOSOMAL_MEMBRANE": "The side (leaflet) of the lysosomal membrane that faces the cytoplasm. [GOC:ab, GOC:dos]", "GOCC_CYTOPLASMIC_REGION": "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. [GOC:dos]", "GOCC_CYTOPLASMIC_SIDE_OF_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE": "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm. [GOC:ab, GOC:dos]", "GOCC_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex found in the cytoplasm. [GOC:mah]", "GOCC_CYTOPLASMIC_SIDE_OF_MEMBRANE": "The side of a membrane that faces the cytoplasm. [GOC:dos]", "GOCC_CYTOPLASMIC_STRESS_GRANULE": "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]", "GOCC_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE": "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]", "GOCC_CYTOSKELETON_OF_PRESYNAPTIC_ACTIVE_ZONE": "", "GOCC_CYTOSOLIC_PROTEASOME_COMPLEX": "", "GOCC_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT": "The large subunit of a ribosome located in the cytosol. [GOC:mtg_sensu]", "GOCC_CYTOSOLIC_REGION": "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol. [GOC:dos]", "GOCC_DEATH_INDUCING_SIGNALING_COMPLEX": "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815]", "GOCC_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT": "The small subunit of a ribosome located in the cytosol. [GOC:mtg_sensu]", "GOCC_DENDRITE_TERMINUS": "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole. [GOC:jl, NIF_Subcellular:sao28175134]", "GOCC_CYTOSOLIC_RIBOSOME": "A ribosome located in the cytosol. [GOC:mtg_sensu]", "GOCC_DENDRITE_CYTOPLASM": "All of the contents of a dendrite, excluding the surrounding plasma membrane. [GOC:mah]", "GOCC_DENDRITIC_GROWTH_CONE": "The migrating motile tip of a growing nerve cell dendrite. [GOC:jl]", "GOCC_DENDRITE_MEMBRANE": "The portion of the plasma membrane surrounding a dendrite. [GOC:mah]", "GOCC_DENDRITIC_SHAFT": "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. [GOC:nln]", "GOCC_DENDRITIC_SPINE_HEAD": "Distal part of the dendritic spine, that carries the post-synaptic density. [GOC:BHF, GOC:nln, GOC:rl]", "GOCC_DENDRITIC_SPINE_MEMBRANE": "The portion of the plasma membrane surrounding a dendritic spine. [GOC:mah]", "GOCC_DENSE_BODY": "An electron dense body which may contain granules. [ISBN:0195065719, NIF_Subcellular:sao730872736]", "GOCC_DENSE_CORE_GRANULE_MEMBRANE": "The lipid bilayer surrounding a dense core granule. [GOC:mah]", "GOCC_DENSE_CORE_GRANULE": "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. [NIF_Subcellular:sao772007592, PMID:14690495]", "GOCC_DESMOSOME": "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. [GOC:mah, GOC:mtg_muscle, ISBN:0815332181]", "GOCC_DERLIN_1_RETROTRANSLOCATION_COMPLEX": "A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]", "GOCC_DEUTEROSOME": "A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles. [GOC:cilia, GOC:dos, PMID:24075808, PMID:25047614, PMID:5661997]", "GOCC_DNA_DEPENDENT_PROTEIN_KINASE_DNA_LIGASE_4_COMPLEX": "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889]", "GOCC_DENDRITIC_TREE": "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches. [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]", "GOCC_DNA_DEPENDENT_PROTEIN_KINASE_COMPLEX": "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku. [GOC:mah, PMID:10854421, PMID:12235392]", "GOCC_DNA_POLYMERASE_COMPLEX": "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. [GOC:jl, PMID:12045093]", "GOCC_DNA_RECOMBINASE_MEDIATOR_COMPLEX": "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange. [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992, PMID:32414915]", "GOCC_DISTAL_AXON": "That part of an axon close to and including the growth cone or the axon terminus. [GOC:aruk, GOC:bc, PMID:17202468]", "GOCC_DNA_REPLICATION_FACTOR_A_COMPLEX": "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. [PMID:9242902]", "GOCC_DNA_REPAIR_COMPLEX": "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]", "GOCC_DNA_REPLICATION_FACTOR_C_COMPLEX": "A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides. [PMID:14614842, PMID:14646196, PMID:16172520]", "GOCC_DNA_REPLICATION_PREINITIATION_COMPLEX": "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184]", "GOCC_DOPAMINERGIC_SYNAPSE": "A synapse that uses dopamine as a neurotransmitter. [GOC:dos]", "GOCC_DYNACTIN_COMPLEX": "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach. [ISBN:0198506732]", "GOCC_DYNEIN_AXONEMAL_PARTICLE": "An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm. [GOC:krc, PMID:30561330, PMID:32898505, PMID:33263282]", "GOCC_DYSTROGLYCAN_COMPLEX": "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin. [PMID:15117830, PMID:16710609]", "GOCC_DYNEIN_COMPLEX": "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. [ISBN:0815316194]", "GOCC_DYSTROPHIN_ASSOCIATED_GLYCOPROTEIN_COMPLEX": "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase. [PMID:15117830, PMID:16710609]", "GOCC_EARLY_ENDOSOME_LUMEN": "The volume enclosed by the membrane of an early endosome. [GOC:mah]", "GOCC_EARLY_PHAGOSOME": "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis. [GOC:mah, PMID:12388753]", "GOCC_EGG_COAT": "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. [PMID:16944418, PMID:17163408]", "GOCC_EARP_COMPLEX": "A quatrefoil tethering complex required for endocytic recycling. [PMID:25799061]", "GOCC_EARLY_ENDOSOME_MEMBRANE": "The lipid bilayer surrounding an early endosome. [GOC:pz]", "GOCC_ELASTIC_FIBER": "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. [GOC:BHF, GOC:mah, PMID:20236620]", "GOCC_EKC_KEOPS_COMPLEX": "A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p. [GOC:elh, GOC:vw, PMID:16564010, PMID:16874308, PMID:21183954, PMID:23945934]", "GOCC_EARLY_ENDOSOME": "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]", "GOCC_ELONGATOR_HOLOENZYME_COMPLEX": "A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA. [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]", "GOCC_ELONGIN_COMPLEX": "A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits. [PMID:12676794]", "GOCC_EMC_COMPLEX": "A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. [PMID:29242231, PMID:30415835, PMID:32459176]", "GOCC_ENDOLYSOSOME": "An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. [GOC:pde, PMID:21878991]", "GOCC_ENDOCYTIC_VESICLE_LUMEN": "The volume enclosed by the membrane of an endocytic vesicle. [GOC:pde]", "GOCC_ENDODEOXYRIBONUCLEASE_COMPLEX": "A protein complex which is capable of endodeoxyribonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]", "GOCC_ENDOCYTIC_VESICLE": "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. [GOC:go_curators, PMID:19696797]", "GOCC_ENDOLYSOSOME_LUMEN": "The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. [GOC:pde]", "GOCC_ENDOCYTIC_VESICLE_MEMBRANE": "The lipid bilayer surrounding an endocytic vesicle. [GOC:mah]", "GOCC_ENDOLYSOSOME_MEMBRANE": "The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. [GOC:pde]", "GOCC_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX": "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. [PMID:12475965]", "GOCC_ENDOPEPTIDASE_COMPLEX": "A protein complex which is capable of endopeptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]", "GOCC_ENDONUCLEASE_COMPLEX": "A protein complex which is capable of endonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]", "GOCC_ENDOPLASMIC_RETICULUM_EXIT_SITE": "An endoplasmic reticulum part at which COPII-coated vesicles are produced. [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]", "GOCC_ENDOPLASMIC_RETICULUM_PALMITOYLTRANSFERASE_COMPLEX": "", "GOCC_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE": "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. [GOC:mah, GOC:pr, PMID:16723730]", "GOCC_ENDOPLASMIC_RETICULUM_PLASMA_MEMBRANE_CONTACT_SITE": "A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes. [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]", "GOCC_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT": "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. [GOC:pr, PMID:16723730]", "GOCC_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT": "A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. [PMID:11408579]", "GOCC_ENDOPLASMIC_RETICULUM_PROTEIN_CONTAINING_COMPLEX": "A protein complex that is part of an endoplasmic reticulum. [GOC:pg]", "GOCC_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK": "A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. [GOC:vw, PMID:16469703, PMID:20434336]", "GOCC_ENDOPLASMIC_RETICULUM_LUMEN": "The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]", "GOCC_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK_MEMBRANE": "The membrane of the endoplasmic reticulum tubular network. [PMID:16469703]", "GOCC_ENZYME_ACTIVATOR_COMPLEX": "A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active. [GOC:bhm, PMID:16244137, PMID:28710280]", "GOCC_EPSILON_DNA_POLYMERASE_COMPLEX": "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair. [PMID:15814431, PMID:9745046]", "GOCC_ENDOSOME_LUMEN": "The volume enclosed by the membrane of an endosome. [GOC:mah]", "GOCC_ENDOSOME": "A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]", "GOCC_EQUATORIAL_MICROTUBULE_ORGANIZING_CENTER": "", "GOCC_ER_MEMBRANE_INSERTION_COMPLEX": "A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast. [GOC:mah, PMID:20676083, PMID:20850366]", "GOCC_ER_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex found in the ER. [GOC:elh]", "GOCC_ENDOSOME_MEMBRANE": "The lipid bilayer surrounding an endosome. [GOC:mah]", "GOCC_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE": "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]", "GOCC_ESCRT_COMPLEX": "An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes. [PMID:16689637, VZ:1536]", "GOCC_ESCRT_I_COMPLEX": "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. [GOC:rb, PMID:12892785, PMID:12900393]", "GOCC_ESC_E_Z_COMPLEX": "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. [GOC:bf, GOC:krc, GOC:sp, PMID:12408863, PMID:12408864, PMID:17107999, PMID:20064375, PMID:31123059, PMID:33232890]", "GOCC_EUCHROMATIN": "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. [PMID:32017156]", "GOCC_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_2B_COMPLEX": "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. [PMID:9438375]", "GOCC_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_2_COMPLEX": "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. [PMID:10216940]", "GOCC_EUKARYOTIC_48S_PREINITIATION_COMPLEX": "The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC. [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639]", "GOCC_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX": "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. [PMID:15904532]", "GOCC_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_4F_COMPLEX": "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. [GOC:hb, PMID:32883864, PMID:8449919]", "GOCC_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX_EIF3M": "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. [PMID:15904532, PMID:19061185]", "GOCC_EXOCYST": "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]", "GOCC_EXCITATORY_SYNAPSE": "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. [GOC:dph, GOC:ef]", "GOCC_EXORIBONUCLEASE_COMPLEX": "A protein complex which is capable of exoribonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17174896]", "GOCC_EXON_EXON_JUNCTION_COMPLEX": "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. [PMID:11532962, PMID:11743026]", "GOCC_EXOCYTIC_VESICLE": "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. [GOC:kad, GOC:mah]", "GOCC_EXTERNAL_SIDE_OF_APICAL_PLASMA_MEMBRANE": "The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:ab, GOC:dos]", "GOCC_EXTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE": "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]", "GOCC_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE": "The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]", "GOCC_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE": "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. [GOC:mah]", "GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE": "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. [GOC:go_curators]", "GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE": "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]", "GOCC_EXTRINSIC_COMPONENT_OF_MEMBRANE": "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos, GOC:jl, GOC:mah]", "GOCC_EXTRINSIC_COMPONENT_OF_POSTSYNAPTIC_MEMBRANE": "The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]", "GOCC_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE": "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:curators, GOC:dos]", "GOCC_EXTRINSIC_COMPONENT_OF_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE": "", "GOCC_EXTRINSIC_COMPONENT_OF_PRESYNAPTIC_MEMBRANE": "The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]", "GOCC_EXTRINSIC_COMPONENT_OF_SYNAPTIC_MEMBRANE": "The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]", "GOCC_EXTRINSIC_COMPONENT_OF_SYNAPTIC_VESICLE_MEMBRANE": "The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]", "GOCC_FACIT_COLLAGEN_TRIMER": "A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences. [PMID:21421911]", "GOCC_FANCONI_ANAEMIA_NUCLEAR_COMPLEX": "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. [GOC:jl, PMID:12093742]", "GOCC_FASCIA_ADHERENS": "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes. [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910]", "GOCC_FC_RECEPTOR_COMPLEX": "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin. [GOC:add, ISBN:0781735149]", "GOCC_FAR_SIN_STRIPAK_COMPLEX": "A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body. [GOC:vw, PMID:21561862, PMID:22119525]", "GOCC_FEMALE_GERM_CELL_NUCLEUS": "The nucleus of the female germ cell, a reproductive cell in females. [CL:0000021, GOC:hjd]", "GOCC_FHF_COMPLEX": "A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex). [GOC:ab, GOC:mah, PMID:18799622]", "GOCC_FEMALE_PRONUCLEUS": "The pronucleus originating from the ovum that is being fertilized. [GOC:hjd, ISBN:0198506732]", "GOCC_FIBRILLAR_COLLAGEN_TRIMER": "Any triple helical collagen trimer that forms fibrils. [PMID:21421911]", "GOCC_FIBRINOGEN_COMPLEX": "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. [ISBN:0198547684]", "GOCC_FIBRILLAR_CENTER": "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]", "GOCC_FILAMENTOUS_ACTIN": "A two-stranded helical polymer of the protein actin. [GOC:mah]", "GOCC_FICOLIN_1_RICH_GRANULE_MEMBRANE": "The lipid bilayer surrounding a ficolin-1-rich granule. [GOC:mec, PMID:23650620]", "GOCC_FICOLIN_1_RICH_GRANULE": "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry. [GOC:mec, PMID:19741154]", "GOCC_FICOLIN_1_RICH_GRANULE_LUMEN": "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]", "GOCC_FILOPODIUM_MEMBRANE": "The portion of the plasma membrane surrounding a filopodium. [GOC:mah]", "GOCC_FILOPODIUM": "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. [GOC:mah, GOC:pr, ISBN:0815316194]", "GOCC_FILOPODIUM_TIP": "The end of a filopodium distal to the body of the cell. [GOC:mah]", "GOCC_FILTRATION_DIAPHRAGM": "A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph. [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]", "GOCC_FLEMMING_BODY": "A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge. [GOC:pm, PMID:18641129, PMID:22522702]", "GOCC_FLOTILLIN_COMPLEX": "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae. [PMID:17206938, PMID:17600709]", "GOCC_F_ACTIN_CAPPING_PROTEIN_COMPLEX": "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. [GOC:go_curators, ISBN:0198599560]", "GOCC_GABA_ERGIC_SYNAPSE": "A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. [GOC:dos]", "GOCC_GAMMA_SECRETASE_COMPLEX": "A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein. [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437]", "GOCC_GAMMA_TUBULIN_RING_COMPLEX": "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe. [GOC:mtg_sensu, PMID:12134075, PMID:17021256]", "GOCC_GABA_RECEPTOR_COMPLEX": "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]", "GOCC_GAMMA_DELTA_T_CELL_RECEPTOR_COMPLEX": "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein. [GOC:mah, ISBN:0781735149]", "GOCC_GAMMA_TUBULIN_COMPLEX": "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. [GOC:clt, PMID:12134075]", "GOCC_GAP_JUNCTION": "A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins. [GOC:mah, GOC:mtg_muscle, ISBN:0815332181, PMID:22366062, Wikipedia:Gap_junction]", "GOCC_GATOR1_COMPLEX": "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]", "GOCC_GARP_COMPLEX": "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles. [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]", "GOCC_GATOR2_COMPLEX": "A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700]", "GOCC_GBAF_COMPLEX": "A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM. [PMID:29374058]", "GOCC_GEMINI_OF_COILED_BODIES": "", "GOCC_GINS_COMPLEX": "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]", "GOCC_GID_COMPLEX": "A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species. [PMID:12686616, PMID:18508925, PMID:35682545]", "GOCC_GERM_CELL_NUCLEUS": "The nucleus of a germ cell, a reproductive cell in multicellular organisms. [CL:0000586, GOC:go_curators]", "GOCC_GLYCINERGIC_SYNAPSE": "A synapse that uses glycine as a neurotransmitter. [GOC:dos]", "GOCC_GLYCOGEN_GRANULE": "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. [GOC:jl, PMID:12179957]", "GOCC_GLYCOPROTEIN_COMPLEX": "A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. [GOC:pf, PMID:7693675, PMID:8662961]", "GOCC_GLIAL_CELL_PROJECTION": "A prolongation or process extending from a glial cell. [GOC:mc]", "GOCC_GLYCOPROTEIN_IB_IX_V_COMPLEX": "A transmembrane signaling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation. [GOC:bhm, PMID:1730602, PMID:23336709, PMID:25297919]", "GOCC_GLYCOSYLPHOSPHATIDYLINOSITOL_N_ACETYLGLUCOSAMINYLTRANSFERASE_GPI_GNT_COMPLEX": "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411]", "GOCC_GLUTAMATERGIC_SYNAPSE": "A synapse that uses glutamate as a neurotransmitter. [GOC:dos]", "GOCC_GOLGI_APPARATUS_SUBCOMPARTMENT": "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus. [GOC:dos]", "GOCC_GOLGI_ASSOCIATED_VESICLE": "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. [GOC:mah]", "GOCC_GOLGI_CISTERNA_MEMBRANE": "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. [GOC:ecd, GOC:mah]", "GOCC_GOLGI_ASSOCIATED_VESICLE_MEMBRANE": "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. [GOC:mah]", "GOCC_GOLGI_CISTERNA": "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. [GOC:mah]", "GOCC_GOLGI_MEDIAL_CISTERNA": "The middle Golgi cisterna (or cisternae). [ISBN:0815316194]", "GOCC_GOLGI_LUMEN": "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. [GOC:mah]", "GOCC_GOLGI_APPARATUS": "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732, PMID:9695800]", "GOCC_GOLGI_CIS_CISTERNA": "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. [ISBN:0815316194]", "GOCC_GOLGI_TRANSPORT_COMPLEX": "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8. [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]", "GOCC_GOLGI_MEMBRANE": "The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]", "GOCC_GRANULAR_COMPONENT": "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm. [PMID:10754561]", "GOCC_GPI_ANCHOR_TRANSAMIDASE_COMPLEX": "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor. [GOC:jl, GOC:rb, PMID:12802054]", "GOCC_GOLGI_TRANS_CISTERNA": "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. [ISBN:0815316194]", "GOCC_GOLGI_STACK": "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. [GOC:mah, ISBN:0815316194]", "GOCC_GROWTH_CONE_MEMBRANE": "The portion of the plasma membrane surrounding a growth cone. [GOC:mah]", "GOCC_GROWTH_FACTOR_COMPLEX": "A protein complex that has growth factor activity. [GOC:bhm]", "GOCC_GTPASE_ACTIVATOR_COMPLEX": "A protein complex which is capable of GTPase activator activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16449187]", "GOCC_GTPASE_COMPLEX": "A protein complex which is capable of GTPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006]", "GOCC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_COMPLEX": "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. [GOC:mah]", "GOCC_G_PROTEIN_COUPLED_RECEPTOR_COMPLEX": "A protein complex that contains G protein-coupled receptors. [GOC:bhm]", "GOCC_G_PROTEIN_COUPLED_RECEPTOR_DIMERIC_COMPLEX": "A protein complex that contains two G protein-coupled receptors. [GOC:al, GOC:bf, PMID:10713101]", "GOCC_H3_HISTONE_ACETYLTRANSFERASE_COMPLEX": "A multisubunit complex that catalyzes the acetylation of histone H3. [GOC:mah]", "GOCC_H4_H2A_HISTONE_ACETYLTRANSFERASE_COMPLEX": "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A. [GOC:mah, GOC:rb]", "GOCC_HAPTOGLOBIN_HEMOGLOBIN_COMPLEX": "A protein complex formed by the stable binding of a haptoglobin to hemoglobin. [GOC:mah]", "GOCC_HAUS_COMPLEX": "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex. [PMID:19427217]", "GOCC_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX": "A protein complex which is capable of H4 histone acetyltransferase activity. [GOC:bhm, GOC:TermGenie, PMID:23775086]", "GOCC_HEMIDESMOSOME": "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces. [GOC:kmv, ISBN:0815316208, PMID:20205195]", "GOCC_HEMOGLOBIN_COMPLEX": "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. [GOC:jl, ISBN:0198506732]", "GOCC_HETEROCHROMATIN": "A compact and highly condensed form of chromatin that is refractory to transcription. [PMID:32017156]", "GOCC_HFE_TRANSFERRIN_RECEPTOR_COMPLEX": "A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription. [GOC:BHF, GOC:kom, PMID:25147378]", "GOCC_HIGH_DENSITY_LIPOPROTEIN_PARTICLE": "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl]", "GOCC_HIPPOCAMPAL_MOSSY_FIBER": "An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal. [NIF_Subcellular:nlx_subcell_100312, PMID:17765709, PMID:20554881, PMID:24336151]", "GOCC_HIPPOCAMPAL_MOSSY_FIBER_TO_CA3_SYNAPSE": "One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762]", "GOCC_HISTONE_PRE_MRNA_3_END_PROCESSING_COMPLEX": "A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1. [GOC:mah, PMID:19470752]", "GOCC_HOPS_COMPLEX": "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. [PMID:10944212, PMID:23645161]", "GOCC_HISTONE_METHYLTRANSFERASE_COMPLEX": "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. [GOC:bf]", "GOCC_HISTONE_DEACETYLASE_COMPLEX": "A protein complex that possesses histone deacetylase activity. [GOC:mah]", "GOCC_HOST_CELLULAR_COMPONENT": "Any cellular component of a host cell. The host is an organism in which another organism, for instance a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. [ISBN:0198506732]", "GOCC_IGA_IMMUNOGLOBULIN_COMPLEX": "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]", "GOCC_IGD_IMMUNOGLOBULIN_COMPLEX": "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:11282392]", "GOCC_IGA_IMMUNOGLOBULIN_COMPLEX_CIRCULATING": "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]", "GOCC_IGG_IMMUNOGLOBULIN_COMPLEX": "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]", "GOCC_IGE_IMMUNOGLOBULIN_COMPLEX": "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]", "GOCC_IGM_IMMUNOGLOBULIN_COMPLEX": "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:20176268]", "GOCC_IMMUNOGLOBULIN_COMPLEX_CIRCULATING": "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. [GOC:add, ISBN:0781735149]", "GOCC_IKAPPAB_KINASE_COMPLEX": "A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203]", "GOCC_INHIBITORY_SYNAPSE": "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. [GOC:dph, GOC:ef]", "GOCC_IMMUNOGLOBULIN_COMPLEX": "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, GOC:jl, ISBN:0781765196]", "GOCC_INNER_ACROSOMAL_MEMBRANE": "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane. [GOC:dph, PMID:3899643, PMID:8936405]", "GOCC_INNER_DYNEIN_ARM": "Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. [GOC:BHF, GOC:vk, PMID:19347929, PMID:2557057, PMID:7962092]", "GOCC_INCLUSION_BODY": "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. [GOC:mah, PMID:11121744]", "GOCC_IMMUNOLOGICAL_SYNAPSE": "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376300]", "GOCC_INNER_KINETOCHORE": "The region of a kinetochore closest to centromeric DNA which contains many CENP proteins organized in various subcomplexes including CENP-C, CENP-LN, CENP-HIKM, CENP-OPQUR and CENP-TWSX, but excluding the CENP-A containing heterochromatin. [GOC:clt, PMID:10619130, PMID:11483983, PMID:32516549]", "GOCC_INO80_COMPLEX": "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity. [GOC:jh, GOC:rb, PMID:19355820]", "GOCC_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX": "Any protein complex that is part of the inner mitochondrial membrane. [GOC:dos]", "GOCC_INO80_TYPE_COMPLEX": "A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. [GOC:rb, PMID:19355820]", "GOCC_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEIN_COMPLEX": "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development. [GOC:jl]", "GOCC_INTEGRATOR_COMPLEX": "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. [PMID:16239144]", "GOCC_INTEGRIN_COMPLEX": "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. [PMID:17543136]", "GOCC_INTERCELLULAR_CANALICULUS": "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates. [ISBN:0721662544]", "GOCC_INSULIN_RESPONSIVE_COMPARTMENT": "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2. [PMID:17644329]", "GOCC_INTERCELLULAR_BRIDGE": "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. [PMID:9635420]", "GOCC_INTERPHOTORECEPTOR_MATRIX": "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance. [PMID:1862095, PMID:2194288]", "GOCC_INTERCALATED_DISC": "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. [GOC:mtg_muscle, PMID:11732910]", "GOCC_INTERSTITIAL_MATRIX": "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. [PMID:33605520, PMID:39223427, PMID:8450001]", "GOCC_INTERCHROMATIN_GRANULE": "", "GOCC_INTERMEDIATE_FILAMENT_CYTOSKELETON": "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. [ISBN:0716731363]", "GOCC_INTRACELLULAR_CYCLIC_NUCLEOTIDE_ACTIVATED_CATION_CHANNEL_COMPLEX": "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. [GOC:mah]", "GOCC_INTRACILIARY_TRANSPORT_PARTICLE": "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]", "GOCC_INTRACILIARY_TRANSPORT_PARTICLE_A": "", "GOCC_INTRACILIARY_TRANSPORT_PARTICLE_B": "The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. [GOC:cilia, GOC:kmv, PMID:14570576, PMID:19253336]", "GOCC_ISWI_TYPE_COMPLEX": "Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair. [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]", "GOCC_IRON_SULFUR_CLUSTER_ASSEMBLY_COMPLEX": "A protein complex capable of assembling an iron-sulfur (Fe-S) cluster. [GOC:bhm, PMID:17350958]", "GOCC_JUNCTIONAL_MEMBRANE_COMPLEX": "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules). [PMID:11535622]", "GOCC_JUNCTIONAL_SARCOPLASMIC_RETICULUM_MEMBRANE": "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane. [GOC:mtg_muscle]", "GOCC_JUXTAPARANODE_REGION_OF_AXON": "A region of an axon near a node of Ranvier that is between the paranode and internode regions. [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]", "GOCC_I_BAND": "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. [ISBN:0321204131]", "GOCC_KAINATE_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX": "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits. [GOC:bf, PMID:18655795]", "GOCC_INTRACELLULAR_PROTEIN_CONTAINING_COMPLEX": "A protein-containing complex located intracellularly. [GOC:pg]", "GOCC_KATANIN_COMPLEX": "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa). [PMID:10910766]", "GOCC_KINETOCHORE_MICROTUBULE": "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. [ISBN:0815316194]", "GOCC_KERATIN_FILAMENT": "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. [ISBN:0716731363]", "GOCC_KINOCILIUM": "A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia. [GOC:cilia, GOC:dph, PMID:15882574]", "GOCC_KINESIN_COMPLEX": "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. [GOC:mah, PMID:32842864]", "GOCC_LAMELLAR_BODY": "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. [GOC:cjm, GOC:jl, PMID:12243725, Wikipedia:Lamellar_granule]", "GOCC_LAMELLIPODIUM_MEMBRANE": "The portion of the plasma membrane surrounding a lamellipodium. [GOC:mah]", "GOCC_LAMININ_COMPLEX": "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes. [GOC:jl, PMID:10842354]", "GOCC_LAMIN_FILAMENT": "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C. [ISBN:0198547684]", "GOCC_LAMELLIPODIUM": "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194]", "GOCC_LATERAL_PART_OF_CELL": "The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells. [GOC:pr]", "GOCC_LATERAL_ELEMENT": "A proteinaceous core found between sister chromatids during meiotic prophase. [GOC:elh]", "GOCC_LARGE_RIBOSOMAL_SUBUNIT": "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). [ISBN:0198506732]", "GOCC_LATE_ENDOSOME_LUMEN": "The volume enclosed by the membrane of a late endosome. [GOC:mah]", "GOCC_LATERAL_PLASMA_MEMBRANE": "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr]", "GOCC_LEWY_BODY": "Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein. [NIF_Subcellular:sao4933778419]", "GOCC_LATE_ENDOSOME_MEMBRANE": "The lipid bilayer surrounding a late endosome. [GOC:pz]", "GOCC_LATE_ENDOSOME": "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]", "GOCC_LIPID_DROPLET": "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb]", "GOCC_LEADING_EDGE_MEMBRANE": "The portion of the plasma membrane surrounding the leading edge of a motile cell. [GOC:mah]", "GOCC_LOW_DENSITY_LIPOPROTEIN_PARTICLE": "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]", "GOCC_LIPOPOLYSACCHARIDE_RECEPTOR_COMPLEX": "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens. [PMID:11706042, PMID:9665271]", "GOCC_LSM2_8_COMPLEX": "A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus. [GOC:bhm, GOC:krc, PMID:19121818, PMID:23221597, PMID:27627834, PMID:28768202]", "GOCC_LSM1_7_PAT1_COMPLEX": "A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway. [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]", "GOCC_LUMENAL_SIDE_OF_ENDOPLASMIC_RETICULUM_MEMBRANE": "The side (leaflet) of the plasma membrane that faces the lumen. [GOC:ab, GOC:dos]", "GOCC_LUMENAL_SIDE_OF_MEMBRANE": "Any side (leaflet) of a membrane that faces the lumen of an organelle. [GOC:dos]", "GOCC_L_TYPE_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX": "A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. [GOC:ame, PMID:12946355]", "GOCC_MALE_GERM_CELL_NUCLEUS": "", "GOCC_MANCHETTE": "A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments. [GOC:krc, PMID:15018141, PMID:22319670, PMID:24440897, PMID:26792866]", "GOCC_MAIN_AXON": "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. [NIF_Subcellular:sao1596975044]", "GOCC_LYSOSOMAL_LUMEN": "The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228]", "GOCC_MALE_PRONUCLEUS": "The pronucleus originating from the spermatozoa that was involved in fertilization. [GOC:hjd, ISBN:0198506732]", "GOCC_MATRIX_SIDE_OF_MITOCHONDRIAL_INNER_MEMBRANE": "The side (leaflet) of the mitochondrial inner membrane that faces the matrix. [GOC:dos]", "GOCC_MANNOSYLTRANSFERASE_COMPLEX": "A complex that possesses mannosyltransferase activity. [GOC:mah]", "GOCC_MCRD_MEDIATED_MRNA_STABILITY_COMPLEX": "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP. [GOC:bhm, PMID:11051545]", "GOCC_MCM_COMPLEX": "A hexameric protein complex required for the initiation and regulation of DNA replication. [GOC:jl, PMID:11282021]", "GOCC_MEIOTIC_COHESIN_COMPLEX": "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. [GOC:mah, PMID:12750522]", "GOCC_MEDIATOR_COMPLEX": "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. [PMID:11454195, PMID:16168358, PMID:17870225]", "GOCC_MEMBRANE_ATTACK_COMPLEX": "", "GOCC_MEIOTIC_SPINDLE": "A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]", "GOCC_MESSENGER_RIBONUCLEOPROTEIN_COMPLEX": "", "GOCC_METHYLOSOME": "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. [PMID:11713266, PMID:11756452]", "GOCC_MEMBRANE_COAT": "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. [GOC:mah]", "GOCC_METHYLTRANSFERASE_COMPLEX": "A protein complex that possesses methyltransferase activity. [GOC:mah]", "GOCC_MHC_CLASS_I_PEPTIDE_LOADING_COMPLEX": "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. [GOC:jl, PMID:10631934]", "GOCC_MHC_CLASS_II_PROTEIN_COMPLEX": "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]", "GOCC_MHC_CLASS_I_PROTEIN_COMPLEX": "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]", "GOCC_MEMBRANE_MICRODOMAIN": "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. [PMID:20044567, PMID:26253820]", "GOCC_MHC_PROTEIN_COMPLEX": "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]", "GOCC_MIB_COMPLEX": "A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1. [PMID:26477565]", "GOCC_MICOS_COMPLEX": "Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60. [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]", "GOCC_MEMBRANE_PROTEIN_COMPLEX": "Any protein complex that is part of a membrane. [GOC:dos]", "GOCC_MICROBODY_LUMEN": "The volume enclosed by the membranes of a microbody. [GOC:mah]", "GOCC_MICROFIBRIL": "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins. [PMID:27026396]", "GOCC_MICROBODY_MEMBRANE": "The lipid bilayer surrounding a microbody. [GOC:mah]", "GOCC_MICROBODY": "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). [ISBN:0198506732]", "GOCC_MICROTUBULE_BUNDLE": "An arrangement of closely apposed microtubules running parallel to each other. [NIF_Subcellular:sao1872343973]", "GOCC_MICROTUBULE_ASSOCIATED_COMPLEX": "Any multimeric complex connected to a microtubule. [GOC:jl]", "GOCC_MICROTUBULE_MINUS_END": "The end of a microtubule that does not preferentially grow (polymerize). [GOC:lb, PMID:23169647]", "GOCC_MICROTUBULE_END": "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. [GOC:pr]", "GOCC_MICROTUBULE_ORGANIZING_CENTER_ATTACHMENT_SITE": "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope. [GOC:mah, PMID:18692466]", "GOCC_MICROTUBULE": "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568]", "GOCC_MICROTUBULE_PLUS_END": "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]", "GOCC_MICROVESICLE": "An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm. [GOC:vesicles, PMID:22418571, PMID:24009894, Wikipedia:Microvesicles]", "GOCC_MICROVILLUS": "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. [ISBN:0815316194]", "GOCC_MICROTUBULE_CYTOSKELETON": "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172]", "GOCC_MIGRASOME": "A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration. [PMID:25342562, PMID:31371827]", "GOCC_MICROTUBULE_ORGANIZING_CENTER": "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]", "GOCC_MICROVILLUS_MEMBRANE": "The portion of the plasma membrane surrounding a microvillus. [GOC:mah]", "GOCC_MISMATCH_REPAIR_COMPLEX": "Any complex formed of proteins that act in mismatch repair. [GOC:mah]", "GOCC_MITOCHONDRIAL_CRISTA": "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria. [ISBN:0198506732]", "GOCC_MITOCHONDRIAL_CRISTA_JUNCTION": "A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane. [GOC:mcc, PMID:21944719, PMID:21987634, PMID:22009199]", "GOCC_MIDBODY": "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. [ISBN:0815316194]", "GOCC_MITOCHONDRIAL_INTERMEMBRANE_SPACE_PROTEIN_TRANSPORTER_COMPLEX": "", "GOCC_MITOCHONDRIAL_LARGE_RIBOSOMAL_SUBUNIT": "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). [GOC:mcc]", "GOCC_MITOCHONDRIAL_PERMEABILITY_TRANSITION_PORE_COMPLEX": "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D). [PMID:10393078]", "GOCC_MITOCHONDRIAL_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O": "", "GOCC_MITOCHONDRIAL_ENVELOPE": "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. [GOC:ai, GOC:pz]", "GOCC_MITOCHONDRIA_ASSOCIATED_ENDOPLASMIC_RETICULUM_MEMBRANE_CONTACT_SITE": "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange. [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109]", "GOCC_MITOCHONDRIAL_PROTEIN_CONTAINING_COMPLEX": "A protein complex that is part of a mitochondrion. [GOC:dos]", "GOCC_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_III": "", "GOCC_MITOCHONDRIAL_MATRIX": "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]", "GOCC_MITOCHONDRIAL_SMALL_RIBOSOMAL_SUBUNIT": "The smaller of the two subunits of a mitochondrial ribosome. [GOC:mcc]", "GOCC_MITOTIC_COHESIN_COMPLEX": "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. [GOC:mah, PMID:12750522]", "GOCC_MITOTIC_SPINDLE_MICROTUBULE": "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole. [GOC:vw]", "GOCC_MITOTIC_SPINDLE_ASTRAL_MICROTUBULE": "Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. [GOC:dph]", "GOCC_MITOTIC_SPINDLE": "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]", "GOCC_MITOTIC_SPINDLE_MIDZONE": "The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner. [GOC:mtg_cell_cycle, GOC:vw]", "GOCC_MKS_COMPLEX": "A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. [GOC:cilia, GOC:sp, PMID:21422230, PMID:21565611, PMID:21725307, PMID:22179047, PMID:25869670, PMID:26595381, PMID:26982032]", "GOCC_MITOTIC_SPINDLE_POLE": "Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:vw]", "GOCC_MLL1_2_COMPLEX": "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. [GOC:sart, PMID:21875999]", "GOCC_MLL3_4_COMPLEX": "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species. [GOC:sart, PMID:21875999]", "GOCC_MITOCHONDRION": "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]", "GOCC_MMXD_COMPLEX": "A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation. [GOC:sp, PMID:20797633]", "GOCC_MON1_CCZ1_COMPLEX": "A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p. [GOC:rb, PMID:20797862]", "GOCC_MPP7_DLG1_LIN7_COMPLEX": "A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions. [GOC:BHF, PMID:17237226]", "GOCC_MRE11_COMPLEX": "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]", "GOCC_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX": "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. [PMID:14749727]", "GOCC_MRNA_CLEAVAGE_FACTOR_COMPLEX": "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. [GOC:mah, PMID:10357856]", "GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX": "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient. [GOC:mah, ISBN:071673706X]", "GOCC_MRNA_EDITING_COMPLEX": "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes. [PMID:11564867, PMID:12139607, PMID:24316715]", "GOCC_MOTILE_CILIUM": "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]", "GOCC_MSL_COMPLEX": "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3. [PMID:16227571, PMID:20018852]", "GOCC_MULTIMERIC_RIBONUCLEASE_P_COMPLEX": "", "GOCC_MULTIVESICULAR_BODY": "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. [PMID:11566881, PMID:16533950]", "GOCC_MULTIVESICULAR_BODY_INTERNAL_VESICLE": "A membrane-bounded vesicle wholly contained within a multivesicular body. [GOC:pde, PMID:21183070]", "GOCC_MULTIVESICULAR_BODY_MEMBRANE": "The lipid bilayer surrounding a multivesicular body. [GOC:mah]", "GOCC_MULTIVESICULAR_BODY_LUMEN": "The volume enclosed by the outermost membrane of a multivesicular body. [GOC:pde, PMID:21183070]", "GOCC_MULTI_PASS_TRANSLOCON_COMPLEX": "A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47). [PMID:36261522, PMID:36261528]", "GOCC_MUSCLE_MYOSIN_COMPLEX": "A filament of myosin found in a muscle cell of any type. [GOC:mah]", "GOCC_MYELIN_SHEATH_ABAXONAL_REGION": "The region of the myelin sheath furthest from the axon. [GOC:BHF, PMID:20237282]", "GOCC_MYOFILAMENT": "Any of the smallest contractile units of a myofibril (striated muscle fiber). [Wikipedia:Myofilament]", "GOCC_MYELIN_SHEATH_ADAXONAL_REGION": "The region of the myelin sheath nearest to the axon. [GOC:BHF, PMID:20237282]", "GOCC_MYELIN_SHEATH": "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. [GOC:cjm, GOC:jl, NIF_Subcellular:sao593830697, Wikipedia:Myelin]", "GOCC_MYOSIN_FILAMENT": "A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. [GOC:mah]", "GOCC_MYOSIN_II_COMPLEX": "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. [Wikipedia:Myosin]", "GOCC_MYOSIN_COMPLEX": "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. [GOC:mah, Wikipedia:Myosin]", "GOCC_M_BAND": "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]", "GOCC_NADPH_OXIDASE_COMPLEX": "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires the cytosolic regulatory subunits at least NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. [GOC:jl, PMID:11483596, PMID:12440767]", "GOCC_NASCENT_POLYPEPTIDE_ASSOCIATED_COMPLEX": "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. [PMID:12475173, PMID:7568149]", "GOCC_NADH_DEHYDROGENASE_COMPLEX": "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. [GOC:mah]", "GOCC_NATA_COMPLEX": "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins. [PMID:12890471]", "GOCC_NBAF_COMPLEX": "A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [GOC:mah, GOC:ss, PMID:17640523]", "GOCC_NETWORK_FORMING_COLLAGEN_TRIMER": "A collagen trimer that forms networks. [PMID:21421911]", "GOCC_NEUROFIBRILLARY_TANGLE": "Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926]", "GOCC_NEUROFILAMENT": "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter. [ISBN:0198506732, ISBN:0716731363, ISBN:0815316194]", "GOCC_NEURONAL_DENSE_CORE_VESICLE": "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176]", "GOCC_NEUROMUSCULAR_JUNCTION": "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. [GOC:nln]", "GOCC_NEURONAL_DENSE_CORE_VESICLE_MEMBRANE": "The lipid bilayer surrounding a neuronal dense core vesicle. [GOC:dos]", "GOCC_NEURONAL_RIBONUCLEOPROTEIN_GRANULE": "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli. [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989]", "GOCC_NEURON_PROJECTION_MEMBRANE": "The portion of the plasma membrane surrounding a neuron projection. [GOC:mah]", "GOCC_NEURON_PROJECTION_CYTOPLASM": "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. [GOC:ha]", "GOCC_NEURON_PROJECTION_TERMINUS": "The specialized, terminal region of a neuron projection such as an axon or a dendrite. [GOC:jl]", "GOCC_NEUROTRANSMITTER_RECEPTOR_COMPLEX": "Any protein complex that is capable of functioning as a neurotransmitter receptor. [GOC:dos]", "GOCC_NF_KAPPAB_COMPLEX": "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression. [ISBN:0849327946]", "GOCC_NLRP3_INFLAMMASOME_COMPLEX": "An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]", "GOCC_NLRP1_INFLAMMASOME_COMPLEX": "An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential. [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]", "GOCC_NEURON_SPINE": "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. [ISBN:0198504888, NIF_Subcellular:sao1145756102]", "GOCC_NEURON_TO_NEURON_SYNAPSE": "A synapse in which pre and post-synaptic cells are neurons. [GOC:dos]", "GOCC_NLS_DEPENDENT_PROTEIN_NUCLEAR_IMPORT_COMPLEX": "A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore. [GOC:jl, PMID:9323123, PMID:9323134, Wikipedia:Importin]", "GOCC_NEURON_PROJECTION": "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, PMID:3077060]", "GOCC_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX": "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. [PMID:8294079]", "GOCC_NODE_OF_RANVIER": "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. [GOC:mh]", "GOCC_NONHOMOLOGOUS_END_JOINING_COMPLEX": "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends. [GOC:mah, PMID:17072889, PMID:17938628]", "GOCC_NPBAF_COMPLEX": "A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. [GOC:mah, GOC:ss, PMID:17640523]", "GOCC_NSL_COMPLEX": "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1. [GOC:lb, PMID:20018852]", "GOCC_NON_MOTILE_CILIUM": "A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]", "GOCC_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX": "Cyclin-dependent protein kinase (CDK) complex found in the nucleus. [GOC:krc]", "GOCC_NUCLEAR_EXOSOME_RNASE_COMPLEX": "A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. [PMID:17174896, PMID:20531386, PMID:26726035]", "GOCC_NUCLEAR_INCLUSION_BODY": "An intranuclear focus at which aggregated proteins have been sequestered. [GOC:jl]", "GOCC_NUCLEAR_CHROMOSOME": "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. [GOC:dph, GOC:mah]", "GOCC_NUCLEAR_ENVELOPE_LUMEN": "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. [GOC:ai]", "GOCC_NUCLEAR_LAMINA": "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane. [ISBN:0198506732, ISBN:0716731363]", "GOCC_NUCLEAR_BODY": "Membraneless organelle present in the nucleoplasm and usually visible by confocal microscopy. [PMID:28577509]", "GOCC_NUCLEAR_INNER_MEMBRANE": "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. [GOC:ma]", "GOCC_NUCLEAR_OUTER_MEMBRANE": "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. [ISBN:0198547684]", "GOCC_NUCLEAR_ENVELOPE": "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport. [ISBN:0198547684, PMID:16164970]", "GOCC_NUCLEAR_PERIPHERY": "The portion of the nuclear lumen proximal to the inner nuclear membrane. [GOC:krc, GOC:mah]", "GOCC_NUCLEAR_MEMBRANE": "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]", "GOCC_NUCLEAR_PORE_CENTRAL_TRANSPORT_CHANNEL": "The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153. [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]", "GOCC_NUCLEAR_PORE_OUTER_RING": "A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates). [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]", "GOCC_NUCLEAR_PORE_NUCLEAR_BASKET": "A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component. [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]", "GOCC_NUCLEAR_PORE": "A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. [ISBN:0198547684]", "GOCC_NUCLEAR_RNA_EXPORT_FACTOR_COMPLEX": "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. [PMID:11780633]", "GOCC_NUCLEAR_REPLICATION_FORK": "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. [GOC:jl, GOC:mtg_sensu]", "GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK": "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]", "GOCC_NUCLEAR_STRESS_GRANULE": "A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:10359787, PMID:12865437]", "GOCC_NUCLEOCYTOPLASMIC_TRANSPORT_COMPLEX": "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores. [GOC:mah]", "GOCC_NUCLEOLAR_EXOSOME_RNASE_COMPLEX": "A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. [PMID:17174896, PMID:20531386, PMID:26726035]", "GOCC_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex found in the nucleus. [GOC:mah]", "GOCC_NUCLEAR_SPECK": "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [PMID:28977640]", "GOCC_NUCLEOID": "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. [GOC:bm, GOC:ma, ISBN:3540076689]", "GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX": "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. [GOC:pg]", "GOCC_NUCLEOLAR_RIBONUCLEASE_P_COMPLEX": "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. [GOC:mah, PMID:12045094]", "GOCC_NUCLEOSOME": "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:elh]", "GOCC_NUCLEOTIDE_ACTIVATED_PROTEIN_KINASE_COMPLEX": "A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae). [GOC:bhm, GOC:mah, GOC:vw]", "GOCC_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX": "Any complex formed of proteins that act in nucleotide-excision repair. [PMID:10915862]", "GOCC_NURF_COMPLEX": "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters. [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]", "GOCC_OLIGOSACCHARYLTRANSFERASE_COMPLEX": "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. The complex includes at least eight non-identical subunits. Different forms of the complex containing distinct subunits have been detected in mammals. [PMID:15835887, PMID:31810196, PMID:32316603]", "GOCC_NURD_COMPLEX": "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. [PMID:10589671, PMID:11743021, PMID:17289569]", "GOCC_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX": "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. [GOC:mah]", "GOCC_OMEGASOME": "Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites. [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649]", "GOCC_NUCLEOLUS": "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]", "GOCC_ORGANELLAR_RIBOSOME": "A ribosome contained within a subcellular membrane-bounded organelle. [GOC:mah, GOC:mcc]", "GOCC_ORGANELLE_ENVELOPE_LUMEN": "The region between the inner and outer lipid bilayers of an organelle envelope. [GOC:mah]", "GOCC_ORIGIN_RECOGNITION_COMPLEX": "A multisubunit complex that is located at the replication origins of a chromosome. [GOC:elh]", "GOCC_ORGANELLE_ENVELOPE": "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. [GOC:mah, GOC:pz]", "GOCC_OUTER_DENSE_FIBER": "A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins. [GOC:cilia, GOC:krc, ISBN:0824072820, PMID:10381817, PMID:21586547, PMID:25361759]", "GOCC_ORGANELLE_MEMBRANE_CONTACT_SITE": "A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. [GOC:jl, PMID:16806880]", "GOCC_OUTER_DYNEIN_ARM": "Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. [GOC:BHF, GOC:vk, PMID:2557057, PMID:6218174]", "GOCC_OUTER_KINETOCHORE": "The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. [GOC:clt, PMID:11483983]", "GOCC_OTHER_ORGANISM_PART": "Any constituent part of a secondary organism with which the first organism is interacting. [GOC:jl]", "GOCC_OUTER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX": "Any protein complex that is part of the outer mitochondrial membrane. [GOC:dos]", "GOCC_ORGANELLE_INNER_MEMBRANE": "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. [GOC:mah]", "GOCC_OUTER_MEMBRANE": "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. [GOC:go_curators]", "GOCC_ORGANELLE_SUBCOMPARTMENT": "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. [GOC:mah, GOC:pz]", "GOCC_OXOGLUTARATE_DEHYDROGENASE_COMPLEX": "A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. [PMID:10672230]", "GOCC_OXIDOREDUCTASE_COMPLEX": "Any protein complex that possesses oxidoreductase activity. [GOC:bhm, PMID:18982432]", "GOCC_PARANODAL_JUNCTION": "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. [PMID:11395001, PMID:14630217]", "GOCC_PALMITOYLTRANSFERASE_COMPLEX": "A protein complex with palmitoyltransferase activity. [GOC:hjd]", "GOCC_PARALLEL_FIBER_TO_PURKINJE_CELL_SYNAPSE": "An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. [PMID:16623829, PMID:3209740]", "GOCC_PAM_COMPLEX_TIM23_ASSOCIATED_IMPORT_MOTOR": "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix. [GOC:mcc, GOC:vw, PMID:14517234, PMID:14638855]", "GOCC_PARASPECKLES": "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. [GOC:jl, PMID:11790299]", "GOCC_PARANODE_REGION_OF_AXON": "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858]", "GOCC_PAR_POLARITY_COMPLEX": "A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. [GOC:lnp, PMID:11113154, PMID:18005931, PMID:22500799, PMID:28682236]", "GOCC_PEPTIDASE_INHIBITOR_COMPLEX": "A protein complex which is capable of peptidase inhibitor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624]", "GOCC_PCG_PROTEIN_COMPLEX": "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. [PMID:9372908]", "GOCC_PERICENTRIC_HETEROCHROMATIN": "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). [PMID:12019236, PMID:20206496, PMID:21437270, PMID:22729156, PMID:9413993]", "GOCC_PERICENTRIOLAR_MATERIAL": "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. [GOC:clt, ISBN:0815316194]", "GOCC_PERICHROMATIN_FIBRILS": "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts. [PMID:14731598]", "GOCC_PERICILIARY_MEMBRANE_COMPARTMENT": "A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis. [GOC:cilia, GOC:dr, GOC:krc, PMID:22342749]", "GOCC_PEPTIDASE_COMPLEX": "A protein complex which is capable of peptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]", "GOCC_PERINEURONAL_NET": "A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain. [GOC:sl, PMID:18364019]", "GOCC_PERINUCLEAR_ENDOPLASMIC_RETICULUM": "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]", "GOCC_PERINUCLEAR_THECA": "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins. [PMID:17289678, PMID:8025156]", "GOCC_PERIKARYON": "The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]", "GOCC_PERINUCLEOLAR_COMPARTMENT": "The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC. [GOC:vw, PMID:21385875, Wikipedia:Perinucleolar_compartment]", "GOCC_PHAGOCYTIC_CUP": "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. [PMID:10358769]", "GOCC_PHAGOCYTIC_VESICLE_LUMEN": "The volume enclosed by the membrane of a phagocytic vesicle. [GOC:rs]", "GOCC_PHAGOCYTIC_VESICLE": "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. [GOC:go_curators, ISBN:0198506732]", "GOCC_PHAGOCYTIC_VESICLE_MEMBRANE": "The lipid bilayer surrounding a phagocytic vesicle. [GOC:mah]", "GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM": "Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]", "GOCC_PHAGOLYSOSOME": "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes. [GOC:mah, PMID:12388753, PMID:14733906]", "GOCC_PHAGOPHORE_ASSEMBLY_SITE": "Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]", "GOCC_PHAGOPHORE_ASSEMBLY_SITE_MEMBRANE": "A cellular membrane associated with the phagophore assembly site. [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324]", "GOCC_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX": "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. [GOC:bf, PMID:24587488]", "GOCC_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX_CLASS_I": "A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast. [GOC:ha, PMID:24587488]", "GOCC_PHOSPHATASE_COMPLEX": "A protein complex which is capable of phosphatase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807]", "GOCC_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX_CLASS_III": "A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI). [GOC:bf, PMID:9255069]", "GOCC_PHOSPHOLIPID_TRANSLOCATING_ATPASE_COMPLEX": "A protein complex that functions as a phospholipid-translocating P-Type ATPase. [GOC:dph, GOC:rb, PMID:15090616]", "GOCC_PHOSPHORYLASE_KINASE_COMPLEX": "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. [PMID:1370475]", "GOCC_PHOTORECEPTOR_CONNECTING_CILIUM": "The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone. [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680]", "GOCC_PHOTORECEPTOR_DISC_MEMBRANE": "Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane. [GOC:bj, GOC:krc, GOC:pde, PMID:11826267, PMID:19501669, PMID:2537204, PMID:26574505, PMID:6771304, PMID:7507907]", "GOCC_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE": "The membrane surrounding the outer segment of a vertebrate photoreceptor. [GOC:jl]", "GOCC_PHOTORECEPTOR_INNER_SEGMENT": "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. [GOC:add, PMID:12019563]", "GOCC_PHOTORECEPTOR_OUTER_SEGMENT": "The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304]", "GOCC_PHOTORECEPTOR_RIBBON_SYNAPSE": "A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. [PMID:15626493]", "GOCC_PICLN_SM_PROTEIN_COMPLEX": "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG. [GOC:mah, PMID:11713266]", "GOCC_PINOSOME": "A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis. [PMID:14731589, PMID:14732047]", "GOCC_PIGMENT_GRANULE": "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. [GOC:jid, GOC:mh]", "GOCC_PIP_BODY": "A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway. [GOC:sp, PMID:20011505]", "GOCC_PI_BODY": "A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes. [GOC:sp, PMID:20011505]", "GOCC_PLASMA_MEMBRANE_RAFT": "A membrane raft that is part of the plasma membrane. [GOC:jl]", "GOCC_PLATELET_ALPHA_GRANULE_LUMEN": "The volume enclosed by the membrane of the platelet alpha granule. [GOC:mah, PMID:8467233]", "GOCC_PLATELET_ALPHA_GRANULE": "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). [PMID:8467233]", "GOCC_PLATELET_ALPHA_GRANULE_MEMBRANE": "The lipid bilayer surrounding the platelet alpha granule. [GOC:mah, PMID:8467233]", "GOCC_PLATELET_DENSE_GRANULE": "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. [GOC:jl, PMID:10403682, PMID:11487378]", "GOCC_PLATELET_DENSE_GRANULE_LUMEN": "The volume enclosed by the membrane of the platelet dense granule. [GOC:mah]", "GOCC_PLATELET_DENSE_GRANULE_MEMBRANE": "The lipid bilayer surrounding the platelet dense granule. [GOC:mah]", "GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX": "Any protein complex that is part of the plasma membrane. [GOC:dos]", "GOCC_PLASMA_MEMBRANE_SIGNALING_RECEPTOR_COMPLEX": "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor. [GOC:dos]", "GOCC_PLATELET_DENSE_TUBULAR_NETWORK": "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. [PMID:1322202]", "GOCC_PLASMA_MEMBRANE_REGION": "A membrane that is a (regional) part of the plasma membrane. [GOC:dos]", "GOCC_PLATELET_DENSE_TUBULAR_NETWORK_MEMBRANE": "The lipid bilayer surrounding the platelet dense tubular network. [GOC:mah, PMID:1322202]", "GOCC_PODOSOME": "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. [PMID:12837608, PMID:15890982]", "GOCC_POLAR_MICROTUBULE": "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart. [ISBN:0815316194]", "GOCC_PML_BODY": "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. [GOC:ma, PMID:10944585]", "GOCC_POLE_PLASM": "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. [GOC:kmv, PMID:17113380]", "GOCC_POLYPRENYL_DIPHOSPHATE_SYNTHASE_COMPLEX": "", "GOCC_PORE_COMPLEX": "A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. [ISBN:0198506732]", "GOCC_POSTSYNAPTIC_CYTOSKELETON": "The portion of the cytoskeleton contained within the postsynapse. [GOC:dos, PMID:19889835]", "GOCC_POSTSYNAPTIC_ACTIN_CYTOSKELETON": "The actin cytoskeleton that is part of a postsynapse. [GOC:dos]", "GOCC_POSTSYNAPTIC_CYTOSOL": "The region of the cytosol consisting of all cytosol that is part of the postsynapse. [GOC:dos]", "GOCC_POLYMERIC_CYTOSKELETAL_FIBER": "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. [GOC:dos]", "GOCC_POSTSYNAPTIC_DENSITY_MEMBRANE": "The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]", "GOCC_POSTSYNAPTIC_ENDOSOME": "An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse. [PMID:20820847]", "GOCC_POSTSYNAPTIC_ENDOCYTIC_ZONE": "A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins. [PMID:17880892]", "GOCC_POSTSYNAPTIC_ENDOSOME_MEMBRANE": "The lipid bilayer surrounding a postsynaptic endosome. [GOC:pz]", "GOCC_POSTSYNAPTIC_RECYCLING_ENDOSOME": "A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation. [PMID:20820847]", "GOCC_POSTSYNAPSE": "The part of a synapse that is part of the post-synaptic cell. [GOC:dos]", "GOCC_POSTSYNAPTIC_MEMBRANE": "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]", "GOCC_POSTSYNAPTIC_SPECIALIZATION_INTRACELLULAR_COMPONENT": "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:dos]", "GOCC_POSTSYNAPTIC_SPECIALIZATION": "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [PMID:22046028]", "GOCC_PRC1_COMPLEX": "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. [GOC:bf, PMID:10412979]", "GOCC_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE": "The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]", "GOCC_PRECATALYTIC_SPLICEOSOME": "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]", "GOCC_POST_MRNA_RELEASE_SPLICEOSOMAL_COMPLEX": "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]", "GOCC_POTASSIUM_CHANNEL_COMPLEX": "An ion channel complex through which potassium ions pass. [GOC:mah]", "GOCC_PREFOLDIN_COMPLEX": "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics. [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]", "GOCC_PRERIBOSOME_SMALL_SUBUNIT_PRECURSOR": "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. [PMID:10567516]", "GOCC_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR": "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. [PMID:10567516]", "GOCC_PRERIBOSOME": "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. [PMID:10567516]", "GOCC_PRESPLICEOSOME": "A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]", "GOCC_PRESYNAPTIC_ACTIVE_ZONE_CYTOPLASMIC_COMPONENT": "A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles. [GOC:dos]", "GOCC_PRESYNAPTIC_CYTOSKELETON": "", "GOCC_PRESYNAPTIC_ACTIVE_ZONE": "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]", "GOCC_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE": "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. [PMID:12812759, PMID:12923177, PMID:3152289]", "GOCC_PRESYNAPTIC_ENDOCYTIC_ZONE": "A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity. [PMID:17455288]", "GOCC_PRESYNAPTIC_CYTOSOL": "The region of the cytosol consisting of all cytosol that is part of the presynapse. [GOC:dos]", "GOCC_PRE_SNORNP_COMPLEX": "A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390]", "GOCC_PRESYNAPSE": "The part of a synapse that is part of the presynaptic cell. [GOC:dos]", "GOCC_PROCENTRIOLE_REPLICATION_COMPLEX": "A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates. [GOC:bhm, PMID:17576815, PMID:18207742, PMID:21059844, PMID:22020124, PMID:24997597]", "GOCC_PRESYNAPTIC_MEMBRANE": "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]", "GOCC_PRONUCLEUS": "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. [ISBN:0198506732]", "GOCC_PROTEASE_INHIBITOR_COMPLEX": "A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity. [GOC:ans, PMID:6323392]", "GOCC_PROTEASOME_ACCESSORY_COMPLEX": "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. [GOC:mtg_sensu]", "GOCC_PROTEASOME_CORE_COMPLEX": "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. [GOC:rb, PMID:10806206]", "GOCC_PROTEASOME_CORE_COMPLEX_BETA_SUBUNIT_COMPLEX": "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus. [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]", "GOCC_PROTEASOME_CORE_COMPLEX_ALPHA_SUBUNIT_COMPLEX": "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]", "GOCC_PROTEASOME_COMPLEX": "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. [GOC:rb, Wikipedia:Proteasome]", "GOCC_PROTEASOME_REGULATORY_PARTICLE_LID_SUBCOMPLEX": "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. [GOC:rb]", "GOCC_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX": "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. [GOC:mtg_sensu, GOC:rb]", "GOCC_PROTEIN_COMPLEX_INVOLVED_IN_CELL_CELL_ADHESION": "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. [GOC:dos]", "GOCC_PROTEIN_COMPLEX_INVOLVED_IN_CELL_MATRIX_ADHESION": "Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion. [GOC:dos]", "GOCC_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION": "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. [GOC:dos]", "GOCC_PROTEIN_FOLDING_CHAPERONE_COMPLEX": "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. [GOC:bhm, PMID:21855797]", "GOCC_PROTEIN_PHOSPHATASE_4_COMPLEX": "A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits. [GOC:bhm, PMID:10026142]", "GOCC_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX": "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. [GOC:mah, GOC:ssd]", "GOCC_PROTEIN_DNA_COMPLEX": "A macromolecular complex containing both protein and DNA molecules. [GOC:mah]", "GOCC_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX": "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. [GOC:mah, ISBN:0198547684, PMID:17245430]", "GOCC_PROTEIN_LIPID_COMPLEX": "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. [GOC:mah]", "GOCC_PROTEIN_KINASE_COMPLEX": "A protein complex which is capable of protein kinase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]", "GOCC_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_CATALYTIC_CORE_F_1": "", "GOCC_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX": "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. [ISBN:0198547684, ISBN:0716743663]", "GOCC_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O": "", "GOCC_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN": "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. [GOC:mah, PMID:10838056]", "GOCC_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX": "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. [GOC:mah, ISBN:0716743663, PMID:16691483]", "GOCC_PROTON_TRANSPORTING_V_TYPE_ATPASE_V0_DOMAIN": "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. [GOC:mah, ISBN:0716743663, PMID:16449553]", "GOCC_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX": "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. [GOC:mah, ISBN:0716743663, PMID:16449553]", "GOCC_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN": "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. [GOC:mah, PMID:10838056]", "GOCC_PROTON_TRANSPORTING_V_TYPE_ATPASE_V1_DOMAIN": "", "GOCC_PRP19_COMPLEX": "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. [GOC:krc, PMID:16540691, PMID:19239890]", "GOCC_PROXIMAL_DENDRITE": "The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma). [GOC:aruk, GOC:bc, PMID:16899232]", "GOCC_PSEUDOPODIUM": "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. [ISBN:0198506732]", "GOCC_PTW_PP1_PHOSPHATASE_COMPLEX": "A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. [GOC:mah, PMID:20516061]", "GOCC_PYRUVATE_DEHYDROGENASE_COMPLEX": "A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. [PMID:36863425]", "GOCC_PWP2P_CONTAINING_SUBCOMPLEX_OF_90S_PRERIBOSOME": "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. [GOC:krc, PMID:15231838]", "GOCC_R2TP_COMPLEX": "A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. [GOC:mcc, PMID:15766533, PMID:21925213]", "GOCC_P_BODY": "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. [GOC:clt, PMID:12730603]", "GOCC_RADIAL_SPOKE": "Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules. [GOC:krc, ISBN:0124325653, PMID:22118931, PMID:25694453, PMID:34871179, PMID:9450971]", "GOCC_RAGULATOR_COMPLEX": "A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]", "GOCC_RADIAL_SPOKE_HEAD": "Protein complex forming portion of the radial spoke that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary or flagellum axoneme. [GOC:cilia, GOC:hjd, GOC:krc, PMID:22754630, PMID:34871179]", "GOCC_RDNA_HETEROCHROMATIN": "A region of heterochromatin located at the rDNA repeats in a chromosome. [GOC:mah, PMID:20661445]", "GOCC_RECYCLING_ENDOSOME": "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]", "GOCC_REPLICATION_FORK": "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. [GOC:mah, ISBN:0198547684]", "GOCC_REPLISOME": "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. [GOC:mah, GOC:vw]", "GOCC_RECYCLING_ENDOSOME_MEMBRANE": "The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]", "GOCC_RESPIRATORY_CHAIN_COMPLEX_IV": "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). [ISBN:0198547684]", "GOCC_RESPIRASOME": "", "GOCC_RIBBON_SYNAPSE": "Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm. [NIF_Subcellular:sao1884931180, PMID:15626493]", "GOCC_RECEPTOR_COMPLEX": "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]", "GOCC_RETROMER_COMPLEX": "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157]", "GOCC_RIBONUCLEASE_MRP_COMPLEX": "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714]", "GOCC_RIBONUCLEASE_P_COMPLEX": "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. [GOC:mah, PMID:12045094]", "GOCC_RIBOSE_PHOSPHATE_DIPHOSPHOKINASE_COMPLEX": "", "GOCC_RIPOPTOSOME": "A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400]", "GOCC_RIBONUCLEOPROTEIN_GRANULE": "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]", "GOCC_RISC_LOADING_COMPLEX": "A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]", "GOCC_RIBOSOMAL_SUBUNIT": "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. [GOC:jl]", "GOCC_RNA_CAP_BINDING_COMPLEX": "A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation. [GOC:mah]", "GOCC_RIBOSOME": "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. [ISBN:0198506732]", "GOCC_RNA_N6_METHYLADENOSINE_METHYLTRANSFERASE_COMPLEX": "A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715, PMID:24407421, PMID:29507755, PMID:29535189, PMID:29547716]", "GOCC_RNAI_EFFECTOR_COMPLEX": "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. [GOC:mah, PMID:14704433]", "GOCC_RIBONUCLEOPROTEIN_COMPLEX": "A macromolecular complex that contains both RNA and protein molecules. [GOC:krc, GOC:vesicles]", "GOCC_RNA_POLYMERASE_III_COMPLEX": "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. [GOC:krc, GOC:mtg_sensu]", "GOCC_RNA_POLYMERASE_COMPLEX": "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. [GOC:mah]", "GOCC_RNA_POLYMERASE_II_CORE_COMPLEX": "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. [GOC:krc, GOC:mtg_sensu]", "GOCC_RNA_POLYMERASE_III_TRANSCRIPTION_REGULATOR_COMPLEX": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III. [GOC:tb]", "GOCC_RNA_POLYMERASE_II_HOLOENZYME": "", "GOCC_RNA_POLYMERASE_I_COMPLEX": "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. [GOC:krc, GOC:mtg_sensu]", "GOCC_RNA_POLYMERASE_I_TRANSCRIPTION_REGULATOR_COMPLEX": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I. [GOC:mah]", "GOCC_RNA_POLYMERASE_II_TRANSCRIPTION_REPRESSOR_COMPLEX": "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter. [GOC:tb]", "GOCC_RNA_POLYMERASE_TRANSCRIPTION_FACTOR_SL1_COMPLEX": "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48. [PMID:15691654]", "GOCC_ROD_PHOTORECEPTOR_OUTER_SEGMENT": "The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]", "GOCC_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATOR_COMPLEX": "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]", "GOCC_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE": "The lipid bilayer surrounding the rough endoplasmic reticulum. [GOC:mah]", "GOCC_ROUGH_ENDOPLASMIC_RETICULUM": "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. [ISBN:0198506732]", "GOCC_RPAP3_R2TP_PREFOLDIN_LIKE_COMPLEX": "A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846]", "GOCC_RSC_TYPE_COMPLEX": "A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231]", "GOCC_RUFFLE": "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. [ISBN:0124325653]", "GOCC_RUFFLE_MEMBRANE": "The portion of the plasma membrane surrounding a ruffle. [GOC:mah]", "GOCC_SAGA_COMPLEX": "A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]", "GOCC_SARCOPLASMIC_RETICULUM": "", "GOCC_SAGA_TYPE_COMPLEX": "A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs). [GOC:mah, PMID:10637607, PMID:17337012]", "GOCC_SARCOPLASM": "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. [ISBN:0198547684]", "GOCC_SARCOPLASMIC_RETICULUM_LUMEN": "The volume enclosed by the membranes of the sarcoplasmic reticulum. [GOC:rph]", "GOCC_SARCOLEMMA": "The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732]", "GOCC_SCAR_COMPLEX": "A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction. [GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101]", "GOCC_SARCOPLASMIC_RETICULUM_MEMBRANE": "The lipid bilayer surrounding the sarcoplasmic reticulum. [GOC:rph]", "GOCC_SCHMIDT_LANTERMAN_INCISURE": "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. [GOC:dgh]", "GOCC_SCF_UBIQUITIN_LIGASE_COMPLEX": "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). [PMID:15571813, PMID:15688063]", "GOCC_SEC61_TRANSLOCON_COMPLEX": "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events. [GOC:mah, PMID:18166647, PMID:32820719, PMID:33960686]", "GOCC_SECONDARY_LYSOSOME": "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome. [GOC:jl, ISBN:0815316194]", "GOCC_SCHAFFER_COLLATERAL_CA1_SYNAPSE": "A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689]", "GOCC_SEH1_ASSOCIATED_COMPLEX": "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p. [GOC:jh, PMID:21454883, PMID:23974112]", "GOCC_SEMAPHORIN_RECEPTOR_COMPLEX": "A stable binary complex of a semaphorin and a plexin, together forming a functional semaphorin receptor. [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544]", "GOCC_SEPTIN_CYTOSKELETON": "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes. [GOC:mah]", "GOCC_SECRETORY_GRANULE": "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. [GOC:mah, ISBN:0198506732]", "GOCC_SECRETORY_GRANULE_MEMBRANE": "The lipid bilayer surrounding a secretory granule. [GOC:mah]", "GOCC_SERINE_TYPE_ENDOPEPTIDASE_COMPLEX": "", "GOCC_SERINE_PROTEASE_INHIBITOR_COMPLEX": "A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity. [GOC:ans, PMID:6323392]", "GOCC_SEROTONIN_RECEPTOR_COMPLEX": "A protein complex that is capable of serotonin receptor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]", "GOCC_SET1C_COMPASS_COMPLEX": "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]", "GOCC_SERINE_TYPE_PEPTIDASE_COMPLEX": "A protein complex which is capable of serine-type peptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18640965]", "GOCC_SECRETORY_VESICLE": "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. [GOC:dos]", "GOCC_SEX_CHROMATIN": "Chromatin that is part of a sex chromosome. [GOC:dos, ISBN:0198506732]", "GOCC_SEX_CHROMOSOME": "A chromosome involved in sex determination. [GOC:elh]", "GOCC_SIGNAL_PEPTIDASE_COMPLEX": "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. [GOC:sgd_curators, PMID:1846444, PMID:7615509]", "GOCC_SHELTERIN_COMPLEX": "A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1. [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880]", "GOCC_SIGNAL_RECOGNITION_PARTICLE": "A complex of protein and RNA which facilitates translocation of proteins across membranes. [GOC:mlg]", "GOCC_SIN3_TYPE_COMPLEX": "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. [PMID:15565322, PMID:18292778]", "GOCC_SMAD_PROTEIN_COMPLEX": "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven. [GOC:bhm, GOC:mah, PMID:9670020]", "GOCC_SITE_OF_DNA_DAMAGE": "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:pg]", "GOCC_SITE_OF_DOUBLE_STRAND_BREAK": "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]", "GOCC_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX": "A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. [GOC:krc, GOC:mah, ISBN:0879695897]", "GOCC_SITE_OF_POLARIZED_GROWTH": "Any part of a cell where non-isotropic growth takes place. [GOC:mah]", "GOCC_SIDE_OF_MEMBRANE": "A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos]", "GOCC_SMC5_SMC6_COMPLEX": "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]", "GOCC_SMALL_RIBOSOMAL_SUBUNIT": "The smaller of the two subunits of a ribosome. [GOC:mah]", "GOCC_SMN_COMPLEX": "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. [PMID:16434402, PMID:17023415]", "GOCC_SMALL_SUBUNIT_PROCESSOME": "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]", "GOCC_SMN_SM_PROTEIN_COMPLEX": "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. [GOC:vw, PMID:11522829, PMID:17401408]", "GOCC_SMOOTH_ENDOPLASMIC_RETICULUM_MEMBRANE": "The lipid bilayer surrounding the smooth endoplasmic reticulum. [GOC:mah]", "GOCC_SMOOTH_ENDOPLASMIC_RETICULUM": "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. [ISBN:0198506732]", "GOCC_SNARE_COMPLEX": "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]", "GOCC_SODIUM_CHANNEL_COMPLEX": "An ion channel complex through which sodium ions pass. [GOC:mah]", "GOCC_SM_LIKE_PROTEIN_FAMILY_COMPLEX": "A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles. [GOC:bhm, GOC:krc, PMID:19121818, PMID:27627834]", "GOCC_SNO_S_RNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX": "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA. [GOC:krc, GOC:mah, ISBN:0879695897, PMID:17284456]", "GOCC_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX": "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732]", "GOCC_SORTING_ENDOSOME": "A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles. [NIF_Subcellular:sao1028571114]", "GOCC_SPECIFIC_GRANULE_LUMEN": "The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]", "GOCC_SPECIFIC_GRANULE_MEMBRANE": "The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]", "GOCC_SPECIFIC_GRANULE": "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:jl, ISBN:0721662544, PMID:7334549]", "GOCC_SOMATODENDRITIC_COMPARTMENT": "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. [GOC:pad, GOC:PARL]", "GOCC_SPECTRIN": "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. [GOC:curators, ISBN:0815316194]", "GOCC_SPERMATOPROTEASOME_COMPLEX": "A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity. [GOC:sp, PMID:23706739]", "GOCC_SPECTRIN_ASSOCIATED_CYTOSKELETON": "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. [GOC:mtg_muscle, PMID:15970557]", "GOCC_SPERM_ANNULUS": "The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity. [GOC:cjm, MP:0009834]", "GOCC_SPERM_CONNECTING_PIECE": "", "GOCC_SPERM_FIBROUS_SHEATH": "A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat. [GOC:BHF, GOC:cilia, GOC:krc, PMID:20731842, PMID:3282552]", "GOCC_SPERM_HEAD": "The part of the late spermatid or spermatozoon that contains the nucleus and acrosome. [PMID:22797892, PMID:24665388]", "GOCC_SPERM_HEAD_PLASMA_MEMBRANE": "The plasma membrane that is part of the head section of a sperm cell. [PMID:24478030]", "GOCC_SPERM_PLASMA_MEMBRANE": "A plasma membrane that is part of a sperm cell. [GOC:cjm]", "GOCC_SPERM_MITOCHONDRIAL_SHEATH": "The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. [GOC:cjm, MP:0009832, PMID:32791035]", "GOCC_SPERM_MIDPIECE": "The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. [GOC:cjm, MP:0009831]", "GOCC_SPHERICAL_HIGH_DENSITY_LIPOPROTEIN_PARTICLE": "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]", "GOCC_SPERM_PRINCIPAL_PIECE": "The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. [GOC:cjm, MP:0009836]", "GOCC_SPINDLE_MIDZONE": "The area in the center of the spindle where the spindle microtubules from opposite poles overlap. [GOC:ai, PMID:15296749]", "GOCC_SPINDLE_MICROTUBULE": "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. [ISBN:0815316194]", "GOCC_SPINDLE_POLE_CENTROSOME": "A centrosome from which one pole of a mitotic or meiotic spindle is organized. [GOC:mah]", "GOCC_SPINDLE": "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. [ISBN:0198547684]", "GOCC_SPINDLE_POLE": "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:clt]", "GOCC_STEREOCILIA_COUPLING_LINK": "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle. [PMID:16775142]", "GOCC_STEREOCILIA_ANKLE_LINK_COMPLEX": "", "GOCC_SPLICEOSOMAL_TRI_SNRNP_COMPLEX": "A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP. [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]", "GOCC_SPLICEOSOMAL_COMPLEX": "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]", "GOCC_STEREOCILIUM_BASE": "The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium. [GOC:krc, PMID:20170899]", "GOCC_STEREOCILIUM_MEMBRANE": "The portion of the plasma membrane surrounding a stereocilium. [GOC:dph, GOC:rph]", "GOCC_STEREOCILIUM_TIP": "A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation. [GOC:ecd, GOC:krc, PMID:17021180, PMID:27565685]", "GOCC_STEREOCILIUM_BUNDLE": "A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. [GOC:ecd, PMID:15661519, PMID:7840137]", "GOCC_SUMO_LIGASE_COMPLEX": "A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex. [PMID:16847351]", "GOCC_STRIATED_MUSCLE_THIN_FILAMENT": "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils. [ISBN:0815316194]", "GOCC_SUPER_ELONGATION_COMPLEX": "A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae. [PMID:17150956, PMID:30102332]", "GOCC_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX": "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]", "GOCC_SWI_SNF_COMPLEX": "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. [GOC:bhm, PMID:12672490]", "GOCC_SWR1_COMPLEX": "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820]", "GOCC_SYMMETRIC_SYNAPSE": "A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typically inhibitory. [GOC:dgh, GOC:ef]", "GOCC_SYNAPSE_ASSOCIATED_EXTRACELLULAR_MATRIX": "The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. [GOC:dos]", "GOCC_SYNAPTIC_CLEFT": "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. [GOC:jl, PMID:30784960]", "GOCC_SUPRAMOLECULAR_COMPLEX": "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. [GOC:dos]", "GOCC_SYNAPTIC_MEMBRANE": "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:BHF, PMID:20410104]", "GOCC_SYNAPTOBREVIN_2_SNAP_25_SYNTAXIN_1A_COMPLEX": "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof). [PMID:10336434]", "GOCC_SYNAPTONEMAL_STRUCTURE": "A proteinaceous scaffold found between homologous chromosomes during meiosis. [GOC:elh, GOC:vw]", "GOCC_SUPRAMOLECULAR_POLYMER": "A polymeric supramolecular structure. [GOC:dos]", "GOCC_SYNAPSE": "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]", "GOCC_TERMINAL_BOUTON": "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]", "GOCC_TELOMERASE_HOLOENZYME_COMPLEX": "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. [PMID:11884619]", "GOCC_SYNAPTIC_VESICLE_MEMBRANE": "The lipid bilayer surrounding a synaptic vesicle. [GOC:mah]", "GOCC_TERTIARY_GRANULE": "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]", "GOCC_TERTIARY_GRANULE_LUMEN": "Any membrane-enclosed lumen that is part of a tertiary granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]", "GOCC_TETRASPANIN_ENRICHED_MICRODOMAIN": "A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities. [GOC:ans, PMID:19709882, PMID:21930792]", "GOCC_THO_COMPLEX": "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]", "GOCC_TERTIARY_GRANULE_MEMBRANE": "The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]", "GOCC_TIGHT_JUNCTION": "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. [ISBN:0815332181]", "GOCC_TIM22_MITOCHONDRIAL_IMPORT_INNER_MEMBRANE_INSERTION_COMPLEX": "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12. [PMID:12191765, PMID:27554484]", "GOCC_TIM23_MITOCHONDRIAL_IMPORT_INNER_MEMBRANE_TRANSLOCASE_COMPLEX": "The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. [PMID:27554484, PMID:8851659]", "GOCC_TOM_COMPLEX": "A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane. [PMID:33035511]", "GOCC_TORC1_COMPLEX": "A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p. [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]", "GOCC_TORC2_COMPLEX": "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p. [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]", "GOCC_TRAMP_COMPLEX": "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control. [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137]", "GOCC_TOR_COMPLEX": "A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. [Wikipedia:MTORC1, Wikipedia:MTORC2]", "GOCC_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX": "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. [GOC:jl]", "GOCC_TRANSCRIPTION_EXPORT_COMPLEX_2": "A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p. [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829]", "GOCC_TRANSCRIPTION_EXPORT_COMPLEX": "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. [GOC:krc, PMID:11979277]", "GOCC_TRANSCRIPTION_FACTOR_TFIIH_HOLO_COMPLEX": "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]", "GOCC_TRANSCRIPTION_FACTOR_TFIIA_COMPLEX": "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). [GOC:jl, PMID:17560669]", "GOCC_TRANSCRIPTION_FACTOR_AP_1_COMPLEX": "A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. [GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor]", "GOCC_TRANSCRIPTION_FACTOR_TFIIIC_COMPLEX": "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions. [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097]", "GOCC_TRANSCRIPTION_FACTOR_TFIID_COMPLEX": "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]", "GOCC_TRANSCRIPTION_FACTOR_TFTC_COMPLEX": "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. [PMID:10373431, PMID:9603525]", "GOCC_TRANSCRIPTION_PREINITIATION_COMPLEX": "A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. [GOC:di, PMID:22751016]", "GOCC_TRANSCRIPTION_REPRESSOR_COMPLEX": "A protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah]", "GOCC_TRANSCRIPTION_REGULATOR_COMPLEX": "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]", "GOCC_TRANSLOCON_COMPLEX": "A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins. [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571]", "GOCC_TRANSLATION_PREINITIATION_COMPLEX": "", "GOCC_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS": "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). [GOC:bhm, GOC:dph]", "GOCC_TRANSFERASE_COMPLEX": "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). [GOC:bhm, PMID:16540464]", "GOCC_TRANS_GOLGI_NETWORK_MEMBRANE": "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. [GOC:mah]", "GOCC_TRANSPORTER_COMPLEX": "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. [GOC:bhm, PMID:15449578]", "GOCC_TRANS_GOLGI_NETWORK": "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194, PMID:9695800]", "GOCC_TRANSPORT_VESICLE_MEMBRANE": "The lipid bilayer surrounding a transport vesicle. [GOC:mah]", "GOCC_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE": "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. [GOC:mah]", "GOCC_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE": "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. [GOC:ai]", "GOCC_TRAPPIII_PROTEIN_COMPLEX": "A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins. [GOC:bhm, PMID:20375281, PMID:22669257]", "GOCC_TRANSPORT_VESICLE": "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. [GOC:mah, PMID:22160157]", "GOCC_TRAPPII_PROTEIN_COMPLEX": "A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. [GOC:bhm, PMID:20375281, PMID:22669257]", "GOCC_TRAPP_COMPLEX": "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active. [GOC:bhm, GOC:vw, PMID:22669257]", "GOCC_TRICARBOXYLIC_ACID_CYCLE_HETEROMERIC_ENZYME_COMPLEX": "Any of the heteromeric enzymes that act in the TCA cycle. [GOC:mah]", "GOCC_TRNA_METHYLTRANSFERASE_COMPLEX": "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA. [GOC:jl, PMID:24904644, PMID:9851972]", "GOCC_TRIGLYCERIDE_RICH_PLASMA_LIPOPROTEIN_PARTICLE": "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood. [GOC:BHF, GOC:mah, GOC:rl]", "GOCC_TRNA_SPLICING_LIGASE_COMPLEX": "A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. [GOC:sp, PMID:21311021]", "GOCC_TROPONIN_COMPLEX": "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. [ISBN:0815316194]", "GOCC_TUBULAR_ENDOSOME": "A network of fine tubules in the vicinity of the Golgi complex and around the centriole. [NIF_Subcellular:sao1570660411, NIF_Subcellular:sao694815499, PMID:11896161]", "GOCC_T_TUBULE": "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194]", "GOCC_T_CELL_RECEPTOR_COMPLEX": "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. [GOC:mah, ISBN:0781735149]", "GOCC_U2AF_COMPLEX": "A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point. [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]", "GOCC_U12_TYPE_SPLICEOSOMAL_COMPLEX": "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]", "GOCC_U1_SNRNP": "A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "GOCC_U2_SNRNP": "A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "GOCC_U2_TYPE_CATALYTIC_STEP_2_SPLICEOSOME": "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]", "GOCC_U4_SNRNP": "A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "GOCC_U2_TYPE_SPLICEOSOMAL_COMPLEX": "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. [GOC:krc, GOC:mah, PMID:11343900]", "GOCC_U5_SNRNP": "A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "GOCC_U6_SNRNP": "A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]", "GOCC_U7_SNRNP": "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs. [PMID:12872004]", "GOCC_UBIQUINONE_BIOSYNTHESIS_COMPLEX": "A protein complex composed of enzymes and accessory factors of the ubiquinone (CoQ) biosynthesis pathway. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. In eukaryotes, the complex is located on the matrix face of the inner mitochondrial membrane and includes COQ3, COQ4, COQ5, COQ6, COQ7, COQ9. [GOC:imk, PMID:27060254, PMID:28927698, PMID:30686758]", "GOCC_UBIQUITIN_CONJUGATING_ENZYME_COMPLEX": "Any complex that possesses ubiquitin conjugating enzyme activity. [GOC:mah]", "GOCC_UNCONVENTIONAL_MYOSIN_COMPLEX": "A portmanteau term for myosins other than myosin II. [GOC:ma]", "GOCC_UNIPLEX_COMPLEX": "A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE. [PMID:24231807]", "GOCC_UBIQUITIN_LIGASE_COMPLEX": "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. [GOC:jh2, PMID:9529603]", "GOCC_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_V0_DOMAIN": "", "GOCC_VCP_NPL4_UFD1_AAA_ATPASE_COMPLEX": "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). [PMID:11813000, PMID:16179952]", "GOCC_VARICOSITY": "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. [GOC:nln]", "GOCC_VACUOLAR_LUMEN": "The volume enclosed within the vacuolar membrane. [ISBN:0198506732]", "GOCC_VACUOLAR_MEMBRANE": "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. [GOC:ai]", "GOCC_VESICLE_COAT": "A membrane coat found on a coated vesicle. [GOC:mah]", "GOCC_VACUOLE": "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. [GOC:mtg_sensu, ISBN:0198506732]", "GOCC_VESICLE_LUMEN": "The volume enclosed by the membrane or protein that forms a vesicle. [GOC:mah, GOC:vesicles]", "GOCC_VOLTAGE_GATED_SODIUM_CHANNEL_COMPLEX": "A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732]", "GOCC_VESICLE_TETHERING_COMPLEX": "Any protein complex that plays a role in vesicle tethering. [GOC:dos, GOC:vw, PMID:27243008]", "GOCC_WEIBEL_PALADE_BODY": "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. [PMID:11935287, PMID:16087708]", "GOCC_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX": "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]", "GOCC_WNT_SIGNALOSOME": "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]", "GOCC_WASH_COMPLEX": "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. [GOC:sp, PMID:19922875]", "GOCC_XY_BODY": "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. [GOC:hjd, GOC:mr, PMID:20622855, Wikipedia:XY_sex-determination_system]", "GOCC_X_CHROMOSOME": "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males. [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system]", "GOCC_ZONA_PELLUCIDA_RECEPTOR_COMPLEX": "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction. [GOC:hjd, PMID:21880732]", "GOCC_VESICLE_MEMBRANE": "The lipid bilayer surrounding any membrane-bounded vesicle in the cell. [GOC:mah, GOC:vesicle]", "GOCC_ZYMOGEN_GRANULE": "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. [GOC:jl, ISBN:0198506732]", "GOCC_ZONULA_ADHERENS": "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. [ISBN:0815316208]", "GOMF_14_3_3_PROTEIN_BINDING": "Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580]", "GOMF_11_CIS_RETINAL_BINDING": "Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A. [PMID:24403072]", "GOMF_1_4_ALPHA_OLIGOGLUCAN_PHOSPHORYLASE_ACTIVITY": "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. [RHEA:41732]", "GOMF_1_ACYLGLYCEROPHOSPHOCHOLINE_O_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]", "GOMF_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY": "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+. [EC:2.7.1.137, RHEA:12709]", "GOMF_1_ALKYL_2_ACETYLGLYCEROPHOSPHOCHOLINE_ESTERASE_ACTIVITY": "Catalysis of the reaction: a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+. [RHEA:17777]", "GOMF_1_PHOSPHATIDYLINOSITOL_3_KINASE_REGULATOR_ACTIVITY": "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. [GOC:ai]", "GOMF_1_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_5_KINASE_ACTIVITY": "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+. [EC:2.7.1.68, RHEA:14425]", "GOMF_1_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_3_KINASE_ACTIVITY": "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + H+. [EC:2.7.1.153, RHEA:21292]", "GOMF_1_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_3_KINASE_ACTIVITY": "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + H+. [EC:2.7.1.154, RHEA:18373]", "GOMF_2_ACYLGLYCEROL_3_PHOSPHATE_O_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA. [GOC:ab, RHEA:14233]", "GOMF_1_PHOSPHATIDYLINOSITOL_BINDING": "Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]", "GOMF_2_IRON_2_SULFUR_CLUSTER_BINDING": "Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]", "GOMF_2_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. [PMID:4016575, RHEA:16741]", "GOMF_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY": "", "GOMF_2_OXOGLUTARATE_DEPENDENT_DIOXYGENASE_ACTIVITY": "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. [GOC:mah]", "GOMF_3_5_DNA_EXONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. [GOC:mah]", "GOMF_3_5_DNA_HELICASE_ACTIVITY": "Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. [EC:5.6.2.4, GOC:jl]", "GOMF_3_5_RNA_HELICASE_ACTIVITY": "Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis. [GOC:jp]", "GOMF_3_5_EXONUCLEASE_ACTIVITY": "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. [GOC:ai]", "GOMF_3_HYDROXYACYL_COA_DEHYDROGENASE_ACTIVITY": "", "GOMF_3_HYDROXYACYL_COA_DEHYDRATASE_ACTIVITY": "Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O. [RHEA:33767]", "GOMF_3_CHLOROALLYL_ALDEHYDE_DEHYDROGENASE_ACTIVITY": "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. [GOC:curators]", "GOMF_3_BETA_HYDROXY_DELTA5_STEROID_DEHYDROGENASE_ACTIVITY": "", "GOMF_3_PHOSPHOADENOSINE_5_PHOSPHOSULFATE_BINDING": "Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai]", "GOMF_4_GALACTOSYL_N_ACETYLGLUCOSAMINIDE_3_ALPHA_L_FUCOSYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.152, RHEA:14257]", "GOMF_3_KETO_STEROL_REDUCTASE_ACTIVITY": "", "GOMF_5S_RRNA_BINDING": "Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. [GOC:jl, ISBN:0321000382]", "GOMF_5ALPHA_ANDROSTANE_3BETA_17BETA_DIOL_DEHYDROGENASE_ACTIVITY": "", "GOMF_4_IRON_4_SULFUR_CLUSTER_BINDING": "Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]", "GOMF_5_3_DNA_HELICASE_ACTIVITY": "Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis. [EC:5.6.2.3, GOC:jl]", "GOMF_5_3_DNA_EXONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. [ISBN:0198547684]", "GOMF_5_3_EXONUCLEASE_ACTIVITY": "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. [GOC:ai]", "GOMF_5_DEOXYRIBOSE_5_PHOSPHATE_LYASE_ACTIVITY": "Catalysis of the reaction: a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+. [PMID:11251121, PMID:16120966, PMID:9614142, RHEA:76255]", "GOMF_5_N_7_METHYLGUANOSINE_5_TRIPHOSPHO_MRNA_HYDROLASE_ACTIVITY": "Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+. [PMID:18820299, PMID:29483298]", "GOMF_7SK_SNRNA_BINDING": "Binding to a 7SK small nuclear RNA (7SK snRNA). [GOC:nhn, PMID:21853533]", "GOMF_7S_RNA_BINDING": "Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). [GOC:jl, PMID:6181418]", "GOMF_ABC_TYPE_GLUTATHIONE_S_CONJUGATE_TRANSPORTER_ACTIVITY": "Catalysis of the reaction: an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H+. [PMID:1455517, RHEA:19121]", "GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY": "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). [EC:7.6.2.2]", "GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY": "Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. [PMID:26517899]", "GOMF_ACETYLCHOLINE_BINDING": "Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]", "GOMF_ACETYLATION_DEPENDENT_PROTEIN_BINDING": "", "GOMF_ACETYLCHOLINE_RECEPTOR_ACTIVITY": "Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "GOMF_ACETYLCHOLINE_GATED_MONOATOMIC_CATION_SELECTIVE_CHANNEL_ACTIVITY": "Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. [GOC:mah, PMID:2466967]", "GOMF_ACETYLCHOLINE_RECEPTOR_BINDING": "Binding to an acetylcholine receptor. [GOC:mah]", "GOMF_ACETYLCHOLINE_RECEPTOR_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of an acetylcholine receptor. [GOC:mah]", "GOMF_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. [ISBN:0198506732]", "GOMF_ACETYLESTERASE_ACTIVITY": "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. [EC:3.1.1.6]", "GOMF_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. [ISBN:0198506732]", "GOMF_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acetyl group to an acceptor molecule. [GOC:ai]", "GOMF_ACETYL_COA_C_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. [RHEA:21564]", "GOMF_ACID_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. [EC:3.1.3.2]", "GOMF_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_ACID_AMINO_ACID_LIGASE_ACTIVITY": "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:jl, GOC:mah]", "GOMF_ACID_THIOL_LIGASE_ACTIVITY": "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.2.1.-, GOC:mah]", "GOMF_ACROSIN_BINDING": "Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. [GOC:mah, PMID:12398221]", "GOMF_ACTININ_BINDING": "Binding to actinin, any member of a family of proteins that crosslink F-actin. [GOC:jl, ISBN:0198506732]", "GOMF_ACTIN_MONOMER_BINDING": "Binding to monomeric actin, also known as G-actin. [GOC:ai]", "GOMF_ACTIVIN_RECEPTOR_ACTIVITY": "Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. [GOC:mah, GOC:signaling, ISBN:0198506732]", "GOMF_ACTIVIN_BINDING": "Binding to activin, a dimer of inhibin-beta subunits. [GOC:jid, GOC:mah]", "GOMF_ACTIN_BINDING": "Binding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]", "GOMF_ACTIN_FILAMENT_BINDING": "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732]", "GOMF_ACTIVE_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_ACTIVIN_RECEPTOR_ACTIVITY_TYPE_I": "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. [GOC:mah, PMID:8622651]", "GOMF_ACTIVIN_RECEPTOR_BINDING": "Binding to an activin receptor. [GOC:BHF, GOC:vk]", "GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_ACYLGLYCEROL_LIPASE_ACTIVITY": "", "GOMF_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. [GOC:ai]", "GOMF_ACYLTRANSFERASE_ACTIVITY_ACYL_GROUPS_CONVERTED_INTO_ALKYL_ON_TRANSFER": "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. [GOC:jl]", "GOMF_ACYL_COA_OXIDASE_ACTIVITY": "Catalysis of the reaction: a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2. [RHEA:38959]", "GOMF_ACYL_COA_BINDING": "Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid. [GOC:krc]", "GOMF_ACYL_COA_HYDROLASE_ACTIVITY": "Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+. [RHEA:70423]", "GOMF_ADENINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. [GOC:go_curators]", "GOMF_ADENOSINE_3_5_BISPHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS": "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). [EC:2.3.1.-]", "GOMF_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). [EC:2.3.-.-]", "GOMF_ADENOSINE_DEAMINASE_ACTIVITY": "Catalysis of the reaction: adenosine + H2O = inosine + NH3. [RHEA:24408]", "GOMF_ADENOSINE_RECEPTOR_BINDING": "Binding to an adenosine receptor. [GOC:mah, GOC:nln]", "GOMF_ADENYLATE_CYCLASE_ACTIVITY": "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. [EC:4.6.1.1]", "GOMF_ADENYLATE_CYCLASE_BINDING": "Binding to an adenylate cyclase. [GOC:jl]", "GOMF_ADENYLATE_CYCLASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of adenylate cyclase. [GOC:dph, GOC:tb]", "GOMF_ADENYLYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an adenylyl group to an acceptor. [GOC:mah]", "GOMF_ADENYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY": "Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. [GOC:kd]", "GOMF_ADENYLATE_KINASE_ACTIVITY": "", "GOMF_ADP_BINDING": "Binding to ADP, adenosine 5'-diphosphate. [GOC:jl]", "GOMF_ADP_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+. [PMID:1470606, RHEA:61436]", "GOMF_ADP_D_RIBOSE_MODIFICATION_DEPENDENT_PROTEIN_BINDING": "Binding to a protein upon ADP-ribosylation of the target protein. [PMID:26673700]", "GOMF_ADP_RIBOSE_DIPHOSPHATASE_ACTIVITY": "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. [EC:3.6.1.13]", "GOMF_ADP_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other. [GOC:ai]", "GOMF_ADRENERGIC_RECEPTOR_ACTIVITY": "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]", "GOMF_ADRENERGIC_RECEPTOR_BINDING": "Binding to an adrenergic receptor. [GOC:mah, GOC:nln]", "GOMF_ADENYL_NUCLEOTIDE_BINDING": "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate. [ISBN:0198506732]", "GOMF_ALANINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_ALDEHYDE_DEHYDROGENASE_NAD_P_PLUS_ACTIVITY": "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. [EC:1.2.1.5]", "GOMF_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. [ISBN:0198506732]", "GOMF_ALCOHOL_DEHYDROGENASE_NADPLUS_ACTIVITY_ZINC_DEPENDENT": "", "GOMF_ALCOHOL_DEHYDROGENASE_NADPPLUS_ACTIVITY": "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or ketone + NADPH + H+. [EC:1.1.1.2]", "GOMF_ALDEHYDE_LYASE_ACTIVITY": "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. [GOC:curators]", "GOMF_ALCOHOL_BINDING": "Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group. [GOC:jl, ISBN:0198506732]", "GOMF_ALCOHOL_DEHYDROGENASE_NAD_P_PLUS_ACTIVITY": "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde or ketone + NAD(P)H + H+. [GOC:curators]", "GOMF_ALDOSE_REDUCTASE_NADPH_ACTIVITY": "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]", "GOMF_ALDO_KETO_REDUCTASE_NADPH_ACTIVITY": "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. [GOC:ai]", "GOMF_ALKALINE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [EC:3.1.3.1]", "GOMF_ALKALI_METAL_ION_BINDING": "Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. [GOC:mah]", "GOMF_ALKANE_1_MONOOXYGENASE_ACTIVITY": "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. [RHEA:19341]", "GOMF_ALL_TRANS_RETINAL_BINDING": "Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A. [GOC:curators]", "GOMF_ALPHA_1_3_FUCOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage. [GOC:ai]", "GOMF_ALPHA_1_4_GLUCOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. [EC:3.2.1.20]", "GOMF_ALL_TRANS_RETINOL_DEHYDROGENASE_NADPPLUS_ACTIVITY": "Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. [RHEA:25033]", "GOMF_ALPHA_2A_ADRENERGIC_RECEPTOR_BINDING": "Binding to an alpha-2A adrenergic receptor. [GOC:mah, GOC:nln]", "GOMF_ALPHA_ACTININ_BINDING": "Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. [PMID:10984498, PMID:11699871, PMID:15014165]", "GOMF_ALPHA_AMYLASE_ACTIVITY": "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. [PMID:12527308]", "GOMF_ALPHA_ADRENERGIC_RECEPTOR_ACTIVITY": "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]", "GOMF_ALPHA_CATENIN_BINDING": "Binding to catenin complex alpha subunit. [GOC:bf]", "GOMF_ALPHA_GLUCOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. [GOC:tb]", "GOMF_ALPHA_KETOGLUTARATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. [GOC:ai, ISBN:0198547684]", "GOMF_ALPHA_N_ACETYLNEURAMINATE_ALPHA_2_8_SIALYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. [EC:2.4.3.8]", "GOMF_ALPHA_N_ACETYLGALACTOSAMINIDE_ALPHA_2_6_SIALYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. [EC:2.4.3.3]", "GOMF_AMIDINE_LYASE_ACTIVITY": "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. [GOC:krc]", "GOMF_AMIDE_BINDING": "Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:mah]", "GOMF_ALPHA_TUBULIN_BINDING": "Binding to the microtubule constituent protein alpha-tubulin. [GOC:jl]", "GOMF_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. [GOC:jl, ISBN:0198506732]", "GOMF_AMINOACYLASE_ACTIVITY": "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. [EC:3.5.1.14]", "GOMF_AMINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]", "GOMF_AMINE_BINDING": "Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group. [GOC:jl]", "GOMF_AMINOACYL_TRNA_HYDROLASE_ACTIVITY": "", "GOMF_AMINOACYL_TRNA_EDITING_ACTIVITY": "", "GOMF_AMINOACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). [GOC:jl]", "GOMF_AMINOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]", "GOMF_AMINOPHOSPHOLIPID_FLIPPASE_ACTIVITY": "Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. [GOC:pg]", "GOMF_AMINO_ACID_MONOATOMIC_CATION_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc. [GOC:curators]", "GOMF_AMINO_ACID_MONOATOMIC_CATION_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). [GOC:ai]", "GOMF_AMINO_ACID_BINDING": "Binding to an amino acid, organic acids containing one or more amino substituents. [GOC:ai]", "GOMF_AMINO_ACID_PROTON_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). [GOC:ai]", "GOMF_AMINO_ACID_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). [GOC:ai]", "GOMF_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_AMMONIA_LYASE_ACTIVITY": "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. [GOC:krc]", "GOMF_AMP_BINDING": "Binding to AMP, adenosine monophosphate. [GOC:go_curators]", "GOMF_AMP_ACTIVATED_PROTEIN_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. [GOC:mah]", "GOMF_AMYLASE_ACTIVITY": "Catalysis of the hydrolysis of amylose or an amylose derivative. [GOC:ai]", "GOMF_ANDROGEN_BINDING": "Binding to an androgen, a male sex hormone. [GOC:jl]", "GOMF_ANAPHASE_PROMOTING_COMPLEX_BINDING": "Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. [GOC:BHF, GOC:dph, GOC:tb]", "GOMF_AMYLOID_BETA_BINDING": "Binding to an amyloid-beta peptide/protein. [GOC:hjd]", "GOMF_ANDROSTAN_3_ALPHA_17_BETA_DIOL_DEHYDROGENASE_ACTIVITY": "", "GOMF_ANKYRIN_BINDING": "Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732]", "GOMF_ANGIOTENSIN_RECEPTOR_ACTIVITY": "", "GOMF_ANGIOTENSIN_RECEPTOR_BINDING": "Binding to an angiotensin receptor. [GOC:mah, GOC:nln]", "GOMF_ANNEALING_ACTIVITY": "An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule. [PMID:22888405]", "GOMF_ANKYRIN_REPEAT_BINDING": "Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure. [GOC:mah, InterPro:IPR002110]", "GOMF_APOLIPOPROTEIN_A_I_BINDING": "Binding to apolipoprotein A-I. [GOC:BHF, GOC:rl]", "GOMF_ANTIPORTER_ACTIVITY": "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]", "GOMF_APOLIPOPROTEIN_BINDING": "Binding to an apolipoprotein, the protein component of a lipoprotein complex. [GOC:BHF, GOC:rl]", "GOMF_ANTIGEN_BINDING": "Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell. [GOC:jl, ISBN:0198506732, ISBN:0721662544]", "GOMF_ANTIOXIDANT_ACTIVITY": "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. [ISBN:0198506732]", "GOMF_APOLIPOPROTEIN_RECEPTOR_BINDING": "Binding to an apolipoprotein receptor. [GOC:BHF, GOC:rl]", "GOMF_AP_1_ADAPTOR_COMPLEX_BINDING": "Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). [PMID:21097499]", "GOMF_AP_2_ADAPTOR_COMPLEX_BINDING": "Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499]", "GOMF_ARACHIDONATE_COA_LIGASE_ACTIVITY": "Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+. [RHEA:19713]", "GOMF_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY": "", "GOMF_ARGININE_BINDING": "Binding to 2-amino-5-(carbamimidamido)pentanoic acid. [GOC:BHF, GOC:rl]", "GOMF_ARMADILLO_REPEAT_DOMAIN_BINDING": "Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation. [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225]", "GOMF_AROMATASE_ACTIVITY": "", "GOMF_ARP2_3_COMPLEX_BINDING": "Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). [GOC:mah]", "GOMF_AROMATIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_ARRESTIN_FAMILY_PROTEIN_BINDING": "Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors. [PMID:23911909]", "GOMF_ARYLSULFATASE_ACTIVITY": "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. [EC:3.1.6.1]", "GOMF_ARYLESTERASE_ACTIVITY": "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. [EC:3.1.1.2]", "GOMF_ARYL_SULFOTRANSFERASE_ACTIVITY": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. [EC:2.8.2.1]", "GOMF_ARYL_HYDROCARBON_RECEPTOR_BINDING": "Binding to an aryl hydrocarbon receptor. [GOC:ai]", "GOMF_ASPARTIC_ENDOPEPTIDASE_ACTIVITY_INTRAMEMBRANE_CLEAVING": "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. [GOC:jl, ISBN:0198506732]", "GOMF_ASPARTIC_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases. [GOC:ai]", "GOMF_ATPASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp]", "GOMF_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]", "GOMF_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]", "GOMF_ATPASE_COUPLED_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY": "Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases. [PMID:16828084]", "GOMF_ATPASE_BINDING": "Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]", "GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out). [GOC:BHF, GOC:rl]", "GOMF_ATPASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces an ATP hydrolysis activity. [GOC:jl]", "GOMF_ATPASE_COUPLED_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). [GOC:ai]", "GOMF_ATP_ACTIVATED_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. [GOC:cb, GOC:mah]", "GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_ATPASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of an ATP hydrolysis activity. [GOC:dph, GOC:tb]", "GOMF_ATP_ADP_ANTIPORTER_ACTIVITY": "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). [TC:2.A.29.1.1]", "GOMF_ATP_DEPENDENT_CHROMATIN_REMODELER_ACTIVITY": "An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]", "GOMF_ATP_DEPENDENT_ACTIVITY_ACTING_ON_RNA": "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. [GOC:jl]", "GOMF_ATP_DEPENDENT_ACTIVITY_ACTING_ON_DNA": "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. [GOC:pdt]", "GOMF_ATP_DEPENDENT_DIACYLGLYCEROL_KINASE_ACTIVITY": "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+. [GOC:elh, RHEA:10272]", "GOMF_ATP_DEPENDENT_DNA_DNA_ANNEALING_ACTIVITY": "An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule. [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634, PMID:22888405]", "GOMF_ATP_DEPENDENT_DNA_DAMAGE_SENSOR_ACTIVITY": "A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. [PMID:33302090, PMID:33510387]", "GOMF_ATP_DEPENDENT_PEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. [GOC:mah]", "GOMF_ATP_DEPENDENT_PROTEIN_BINDING": "Binding to a protein or protein complex using energy from ATP hydrolysis. [GOC:jl]", "GOMF_ATP_DEPENDENT_ACTIVITY": "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient. [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]", "GOMF_ATP_DEPENDENT_PROTEIN_DISAGGREGASE_ACTIVITY": "An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates. [PMID:26312418]", "GOMF_ATP_GATED_ION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. [GOC:bf]", "GOMF_ATP_DEPENDENT_PROTEIN_FOLDING_CHAPERONE": "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. [PMID:27365453]", "GOMF_ATP_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other. [GOC:ai]", "GOMF_AXON_GUIDANCE_RECEPTOR_ACTIVITY": "Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666]", "GOMF_AZOLE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]", "GOMF_BASIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_BENZODIAZEPINE_RECEPTOR_ACTIVITY": "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. [GOC:jl]", "GOMF_ATP_HYDROLYSIS_ACTIVITY": "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]", "GOMF_BENZODIAZEPINE_RECEPTOR_BINDING": "Binding to a peripheral benzodiazepine receptor (PBR). [GOC:ceb, GOC:mah, PMID:9915832]", "GOMF_BASAL_TRANSCRIPTION_MACHINERY_BINDING": "Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. [GOC:txnOH]", "GOMF_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. [PMID:11551958]", "GOMF_BETA_2_ADRENERGIC_RECEPTOR_BINDING": "Binding to a beta-2 adrenergic receptor. [GOC:mah, GOC:nln]", "GOMF_BETA_2_MICROGLOBULIN_BINDING": "Binding to beta-2-microglobulin. [GOC:mah]", "GOMF_BETA_GALACTOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. [EC:3.2.1.23]", "GOMF_BETA_CATENIN_BINDING": "Binding to a catenin beta subunit. [GOC:bf]", "GOMF_BETA_GLUCOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. [EC:3.2.1.21, PMID:12594539]", "GOMF_BETA_GALACTOSIDE_CMP_ALPHA_2_3_SIALYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. [EC:2.4.3.4]", "GOMF_BETA_N_ACETYLHEXOSAMINIDASE_ACTIVITY": "", "GOMF_BETA_TUBULIN_BINDING": "Binding to the microtubule constituent protein beta-tubulin. [GOC:krc]", "GOMF_BH3_DOMAIN_BINDING": "", "GOMF_BICARBONATE_MONOATOMIC_ANION_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in). [PMID:12440690]", "GOMF_BH_DOMAIN_BINDING": "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]", "GOMF_BHLH_TRANSCRIPTION_FACTOR_BINDING": "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. [PMID:9144210]", "GOMF_BILE_ACID_BINDING": "Binding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph]", "GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:ai]", "GOMF_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. [GOC:ai]", "GOMF_BILE_ACID_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). [TC:2.A.28.-.-]", "GOMF_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY": "Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770]", "GOMF_BIOTIN_BINDING": "", "GOMF_BIS_5_ADENOSYL_PENTAPHOSPHATASE_ACTIVITY": "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. [PMID:10085096, PMID:9450008]", "GOMF_BITTER_TASTE_RECEPTOR_ACTIVITY": "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. [GOC:mah]", "GOMF_BMP_BINDING": "Binding to a member of the bone morphogenetic protein (BMP) family. [GOC:BHF, PMID:9660951]", "GOMF_BMP_RECEPTOR_ACTIVITY": "Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity. [GOC:BHF, GOC:dos]", "GOMF_BMP_RECEPTOR_BINDING": "Binding to a BMP receptor. [GOC:BHF, GOC:vk]", "GOMF_BRANCHED_CHAIN_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. [GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729]", "GOMF_BUBBLE_DNA_BINDING": "Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. [GOC:elh, GOC:vw, PMID:16781730]", "GOMF_C2H2_ZINC_FINGER_DOMAIN_BINDING": "Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. [GOC:BHF, GOC:mah, Pfam:PF00096]", "GOMF_C4_DICARBOXYLATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. [GOC:krc]", "GOMF_C3HC4_TYPE_RING_FINGER_DOMAIN_BINDING": "Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. [GOC:amm, InterPro:IPR001841, InterPro:IPR018957]", "GOMF_CADMIUM_ION_BINDING": "Binding to a cadmium ion (Cd). [GOC:ai]", "GOMF_CALCITONIN_FAMILY_RECEPTOR_ACTIVITY": "Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity. [GOC:bhm, InterPro:IPR003287, PMID:10871296, PMID:12037140, PMID:18687416]", "GOMF_CADHERIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION": "Any cadherin binding that occurs as part of the process of cell-cell adhesion. [GOC:dos]", "GOMF_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a potassium cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts. [GOC:dph, GOC:mtg_transport]", "GOMF_CALCIUM_CHANNEL_INHIBITOR_ACTIVITY": "Binds to and stops, prevents, or reduces the activity of a calcium channel. [GOC:mah]", "GOMF_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. [GOC:mah]", "GOMF_CADHERIN_BINDING": "Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]", "GOMF_CALCIUM_CHANNEL_REGULATOR_ACTIVITY": "Modulates the activity of a calcium channel. [GOC:mah]", "GOMF_CALCIUM_DEPENDENT_PHOSPHOLIPASE_A2_ACTIVITY": "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [PMID:34831185]", "GOMF_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING": "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. [GOC:jl]", "GOMF_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "", "GOMF_CALCIUM_DEPENDENT_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY": "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. [GOC:mah]", "GOMF_CALCIUM_DEPENDENT_PROTEIN_SERINE_THREONINE_PHOSPHATASE_REGULATOR_ACTIVITY": "Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. [GOC:ai]", "GOMF_CALCIUM_DEPENDENT_PROTEIN_BINDING": "Binding to a protein or protein complex in the presence of calcium. [GOC:jid, PMID:10485905]", "GOMF_CALCIUM_INDEPENDENT_PHOSPHOLIPASE_A2_ACTIVITY": "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. [PMID:34831185]", "GOMF_CALCIUM_INDUCED_CALCIUM_RELEASE_ACTIVITY": "Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration. [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752]", "GOMF_CALCIUM_MONOATOMIC_CATION_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). [TC:2.A.19.-.-]", "GOMF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. [GOC:dgf]", "GOMF_CALCIUM_SODIUM_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). [GOC:curators, PMID:16371597]", "GOMF_CALCIUM_SENSITIVE_GUANYLATE_CYCLASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. [GOC:mah]", "GOMF_CALCIUM_POTASSIUM_SODIUM_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). [TC:2.A.19.4.1]", "GOMF_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "", "GOMF_CALMODULIN_DEPENDENT_PROTEIN_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. [GOC:mah, PMID:15359118]", "GOMF_CAMP_BINDING": "Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). [GOC:ai]", "GOMF_CALMODULIN_BINDING": "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]", "GOMF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [PMID:32935175, PMID:35053423, PMID:35805104]", "GOMF_CAMP_DEPENDENT_PROTEIN_KINASE_INHIBITOR_ACTIVITY": "", "GOMF_CALCIUM_ION_BINDING": "Binding to a calcium ion (Ca2+). [GOC:ai]", "GOMF_CAMP_DEPENDENT_PROTEIN_KINASE_REGULATOR_ACTIVITY": "Modulation of the activity of the enzyme cAMP-dependent protein kinase. [GOC:ai]", "GOMF_CAMP_RESPONSE_ELEMENT_BINDING": "Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. [PMID:2875459, PMID:2900470]", "GOMF_CAMP_RESPONSE_ELEMENT_BINDING_PROTEIN_BINDING": "Binding to a cAMP response element binding protein (a CREB protein). [GOC:mah]", "GOMF_CARBOHYDRATE_BINDING": "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]", "GOMF_CARBOHYDRATE_DERIVATIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of carbohydrate derivative from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]", "GOMF_CARBOHYDRATE_KINASE_ACTIVITY": "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. [GOC:jl]", "GOMF_CARBOHYDRATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. [GOC:mah]", "GOMF_CARBOHYDRATE_MONOATOMIC_CATION_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). [GOC:ai]", "GOMF_CARBOHYDRATE_PROTON_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). [TC:2.A.1.1]", "GOMF_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of carbohydrate from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]", "GOMF_CARBONYL_REDUCTASE_NADPH_ACTIVITY": "Catalysis of the reaction: a secondary alcohol + NADP+ = a ketone + H+ + NADPH. [RHEA:19257]", "GOMF_CARBONATE_DEHYDRATASE_ACTIVITY": "Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1]", "GOMF_CARBON_CARBON_LYASE_ACTIVITY": "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]", "GOMF_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR": "Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen. [PMID:12360532]", "GOMF_CARBON_NITROGEN_LYASE_ACTIVITY": "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). [EC:4.3.-.-]", "GOMF_CARBON_OXYGEN_LYASE_ACTIVITY": "Catalysis of the breakage of a carbon-oxygen bond. [EC:4.2.-.-]", "GOMF_CARBOXYLESTERASE_ACTIVITY": "Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. [RHEA:21164]", "GOMF_CARBON_SULFUR_LYASE_ACTIVITY": "Catalysis of the elimination of hydrogen sulfide or substituted H2S. [EC:4.4.-.-]", "GOMF_CARBOXY_LYASE_ACTIVITY": "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. [GOC:curators]", "GOMF_CARDIOLIPIN_BINDING": "Binding to cardiolipin. [GOC:kmv, GOC:TermGenie]", "GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY": "Catalysis of the hydrolysis of a carboxylic ester bond. [GOC:curators]", "GOMF_CARD_DOMAIN_BINDING": "Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. [PMID:12054670]", "GOMF_CARGO_ADAPTOR_ACTIVITY": "Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery. [PMID:25795254]", "GOMF_CARBOXYPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]", "GOMF_CARNITINE_O_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule. [GOC:ai]", "GOMF_CARGO_RECEPTOR_ACTIVITY": "Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles. [PMID:15239958, PMID:27903609]", "GOMF_CASPASE_BINDING": "Binding to a caspase family protein. [GOC:dos, GOC:ha]", "GOMF_CARNITINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:ai]", "GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_GLYCOPROTEIN": "Catalysis of a biochemical reaction in which one of the substrates is a glycoprotein. [GOC:molecular_function_refactoring, GOC:pdt]", "GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_RRNA": "Catalytic activity that acts to modify a ribosomal RNA. [GOC:molecular_function_refactoring, GOC:pdt]", "GOMF_CATECHOLAMINE_BINDING": "Binding to catecholamine. [GOC:TermGenie]", "GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA": "Catalytic activity that acts to modify a tRNA. [GOC:molecular_function_refactoring, GOC:pdt]", "GOMF_CCR1_CHEMOKINE_RECEPTOR_BINDING": "Binding to a CCR1 chemokine receptor. [GOC:mah, GOC:nln]", "GOMF_CATALYTIC_ACTIVITY_ACTING_ON_DNA": "Catalytic activity that acts to modify DNA. [GOC:molecular_function_refactoring, GOC:pdt]", "GOMF_CCR2_CHEMOKINE_RECEPTOR_BINDING": "Binding to a CCR2 chemokine receptor. [GOC:mah, GOC:nln]", "GOMF_CCR3_CHEMOKINE_RECEPTOR_BINDING": "Binding to a CCR3 chemokine receptor. [GOC:mah, GOC:nln]", "GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA": "Catalytic activity that acts to modify RNA. [GOC:molecular_function_refactoring, GOC:pdt]", "GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID": "Catalytic activity that acts to modify a nucleic acid. [GOC:pg]", "GOMF_CCR5_CHEMOKINE_RECEPTOR_BINDING": "Binding to a CCR5 chemokine receptor. [GOC:mah, GOC:nln]", "GOMF_CCR6_CHEMOKINE_RECEPTOR_BINDING": "Binding to a CCR6 chemokine receptor. [GOC:mah, GOC:nln]", "GOMF_CDP_ALCOHOL_PHOSPHATIDYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. [GOC:ai]", "GOMF_CD4_RECEPTOR_BINDING": "Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages. [GOC:jl, MSH:D015704]", "GOMF_CCR_CHEMOKINE_RECEPTOR_BINDING": "Binding to a CCR chemokine receptor. [GOC:ai]", "GOMF_CELL_MATRIX_ADHESION_MEDIATOR_ACTIVITY": "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix. [Wikipedia:Cell_adhesion]", "GOMF_CERAMIDE_1_PHOSPHATE_BINDING": "Binding to ceramide 1-phosphate. [GOC:TermGenie, PMID:23863933]", "GOMF_CENTROMERIC_DNA_BINDING": "Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. [GOC:jl, SO:0000577]", "GOMF_CELL_ADHESIVE_PROTEIN_BINDING_INVOLVED_IN_BUNDLE_OF_HIS_CELL_PURKINJE_MYOCYTE_COMMUNICATION": "Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOMF_CELL_ADHESION_MEDIATOR_ACTIVITY": "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell. [GOC:vw, Wikipedia:Cell_adhesion]", "GOMF_CELL_CELL_ADHESION_MEDIATOR_ACTIVITY": "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell. [Wikipedia:Cell_adhesion]", "GOMF_CERAMIDE_BINDING": "Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes. [GOC:sart]", "GOMF_CGMP_BINDING": "Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). [GOC:ai]", "GOMF_CERAMIDE_1_PHOSPHATE_TRANSFER_ACTIVITY": "", "GOMF_CELL_ADHESION_MOLECULE_BINDING": "Binding to a cell adhesion molecule. [GOC:ai]", "GOMF_CHEMOATTRACTANT_ACTIVITY": "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. [GOC:go_curators, ISBN:0198506732]", "GOMF_CHEMOKINE_BINDING": "Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:ai, GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]", "GOMF_CHEMOKINE_ACTIVITY": "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]", "GOMF_CHEMOREPELLENT_ACTIVITY": "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. [GOC:ai]", "GOMF_CHEMOKINE_RECEPTOR_BINDING": "Binding to a chemokine receptor. [GOC:ai]", "GOMF_CHITINASE_ACTIVITY": "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. [GOC:bf, GOC:kah, GOC:pde, PMID:11468293]", "GOMF_CHITIN_BINDING": "Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]", "GOMF_CHLORIDE_CHANNEL_INHIBITOR_ACTIVITY": "Binds to and stops, prevents, or reduces the activity of a chloride channel. [GOC:mah]", "GOMF_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a chloride channel. [GOC:mah]", "GOMF_CHLORIDE_CHANNEL_ACTIVITY": "Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "GOMF_CHLORIDE_ION_BINDING": "Binding to a chloride ion (Cl-). [GOC:mah]", "GOMF_CHOLESTEROL_BINDING": "Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]", "GOMF_CHONDROITIN_SULFATE_BINDING": "Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). [GOC:kmv, ISBN:0198506732]", "GOMF_CHLORIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of chloride ions from one side of a membrane to the other. [GOC:ai]", "GOMF_CHONDROITIN_SULFOTRANSFERASE_ACTIVITY": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate. [GOC:curators]", "GOMF_CHOLINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:ai]", "GOMF_CHROMATIN_INSULATOR_SEQUENCE_BINDING": "", "GOMF_CHROMATIN_DNA_BINDING": "Binding to DNA that is assembled into chromatin. [GOC:mah]", "GOMF_CHROMO_SHADOW_DOMAIN_BINDING": "Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093]", "GOMF_CHROMATIN_PROTEIN_ADAPTOR_ACTIVITY": "An adaptor activity that brings together a protein and a region of the chromatin, such as a nucleosome, to establish or maintain the chromatin localization of the protein, or the complex to which it belongs. [PMID:32277274]", "GOMF_CHROMATIN_BINDING": "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]", "GOMF_CILIARY_NEUROTROPHIC_FACTOR_RECEPTOR_BINDING": "Binding to a ciliary neurotrophic factor receptor. [GOC:ai]", "GOMF_CLASS_I_DNA_APURINIC_OR_APYRIMIDINIC_SITE_ENDONUCLEASE_ACTIVITY": "Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. [PMID:1698278, RHEA:66592]", "GOMF_CIS_TRANS_ISOMERASE_ACTIVITY": "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. [GOC:mah, ISBN:0198506732]", "GOMF_CLATHRIN_BINDING": "Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. [GOC:jl, GOC:mah, ISBN:0198506732]", "GOMF_CLATHRIN_HEAVY_CHAIN_BINDING": "Binding to a clathrin heavy chain. [GOC:mah]", "GOMF_COA_LIGASE_ACTIVITY": "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. [GOC:ai]", "GOMF_CLATHRIN_LIGHT_CHAIN_BINDING": "Binding to a clathrin light chain. [GOC:mah]", "GOMF_COBALAMIN_BINDING": "Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. [GOC:mah]", "GOMF_COA_TRANSFERASE_ACTIVITY": "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). [GOC:jl]", "GOMF_CIS_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING": "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. [GOC:txnOH-2018]", "GOMF_COENZYME_A_DIPHOSPHATASE_ACTIVITY": "Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate. [PMID:10922370, PMID:16185196]", "GOMF_COLLAGEN_BINDING_INVOLVED_IN_CELL_MATRIX_ADHESION": "Any collagen binding that occurs as part of cell-matrix adhesion. [GOC:dos]", "GOMF_COLLAGEN_BINDING": "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732]", "GOMF_COLLAGEN_RECEPTOR_ACTIVITY": "Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:uh, PMID:21568710]", "GOMF_COMPLEMENT_BINDING": "Binding to a component or product of the complement cascade. [GOC:add, ISBN:0781735149]", "GOMF_COMPLEMENT_COMPONENT_C1Q_COMPLEX_BINDING": "Binding to a C1q complex, a component of the classical complement cascade. [GOC:add, ISBN:0781735149]", "GOMF_COMPLEMENT_RECEPTOR_ACTIVITY": "Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:ai, GOC:pg, GOC:signaling, ISBN:0781735149, PMID:11884446]", "GOMF_COMPLEMENT_COMPONENT_C3B_BINDING": "Binding to a C3b product of the complement cascade. [GOC:add, ISBN:0781735149]", "GOMF_CONNEXIN_BINDING": "Binding to a connexin, any of a group of related proteins that assemble to form gap junctions. [GOC:mah, PMID:19864490]", "GOMF_COPPER_CHAPERONE_ACTIVITY": "Directly binding to and delivering copper ions to a target protein. [PMID:10790544, PMID:11739376]", "GOMF_COPPER_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of copper (Cu) ions from one side of a membrane to the other. [GOC:ai]", "GOMF_COPPER_ION_BINDING": "Binding to a copper (Cu) ion. [GOC:ai]", "GOMF_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING": "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. [GOC:pg, GOC:txnOH]", "GOMF_CO_RECEPTOR_BINDING": "Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell. [GOC:bf, GOC:jl]", "GOMF_CORECEPTOR_ACTIVITY": "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]", "GOMF_CORTICOTROPIN_RELEASING_HORMONE_RECEPTOR_BINDING": "Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. [GOC:ai]", "GOMF_CO_SMAD_BINDING": "Binding to a common mediator SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]", "GOMF_CROSSOVER_JUNCTION_DNA_ENDONUCLEASE_ACTIVITY": "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). [EC:3.1.21.10]", "GOMF_CTPASE_ACTIVITY": "Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction. [RHEA:29387]", "GOMF_CULLIN_FAMILY_PROTEIN_BINDING": "Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). [GOC:ha, InterPro:IPR016158, PMID:18698375]", "GOMF_CUPRIC_ION_BINDING": "Binding to a cupric ion, copper(2+). [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]", "GOMF_CUPROUS_ION_BINDING": "Binding to a cuprous ion, copper(1+). [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]", "GOMF_CXCR_CHEMOKINE_RECEPTOR_BINDING": "Binding to a chemokine receptor in the CXCR family. [GOC:ceb, PMID:11910892]", "GOMF_CYCLASE_ACTIVITY": "Catalysis of a ring closure reaction. [ISBN:0198547684]", "GOMF_CXCR3_CHEMOKINE_RECEPTOR_BINDING": "Binding to a CXCR3 chemokine receptor. [GOC:jid, PMID:10556837]", "GOMF_CYCLASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]", "GOMF_CYCLASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]", "GOMF_CYCLASE_INHIBITOR_ACTIVITY": "Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]", "GOMF_CYCLIC_NUCLEOTIDE_ACTIVATED_MONOATOMIC_ION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. [GOC:jl]", "GOMF_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY": "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. [GOC:mah]", "GOMF_CYCLIC_NUCLEOTIDE_BINDING": "Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:ai]", "GOMF_CYCLIC_NUCLEOTIDE_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. [GOC:mah]", "GOMF_CYCLIN_BINDING": "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. [GOC:ai]", "GOMF_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810]", "GOMF_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:mah, GOC:pr]", "GOMF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY": "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:pr]", "GOMF_CYCLOSPORIN_A_BINDING": "Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. [GOC:mb]", "GOMF_CYCLOHYDROLASE_ACTIVITY": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring. [GOC:mah]", "GOMF_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY": "", "GOMF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a cysteine-type endopeptidase. [PMID:32558991]", "GOMF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS": "", "GOMF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]", "GOMF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS": "", "GOMF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY": "", "GOMF_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS": "Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]", "GOMF_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS": "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]", "GOMF_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. [GOC:dph, GOC:tb]", "GOMF_CYSTEINE_TYPE_EXOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]", "GOMF_CYTIDINE_DEAMINASE_ACTIVITY": "Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+. [EC:3.5.4.5]", "GOMF_CYTIDYLYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a cytidylyl group to an acceptor. [GOC:mah]", "GOMF_CYTOCHROME_B5_REDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H": "Catalysis of the reaction: 2 Fe(III)-[cytochrome b5] + NAD(P)H = 2 Fe(II)-[cytochrome b5] + NAD(P)+ + H+. [GOC:curators]", "GOMF_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]", "GOMF_CYTOKINE_BINDING": "Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. [GOC:ai, GOC:bf, ISBN:0198599471]", "GOMF_CYTOKINE_ACTIVITY": "The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]", "GOMF_CYTOSKELETAL_ANCHOR_ACTIVITY": "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07, PMID:30323238]", "GOMF_CYTOKINE_RECEPTOR_ACTIVITY": "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:mah]", "GOMF_CYTOKINE_RECEPTOR_BINDING": "Binding to a cytokine receptor. [GOC:mah, GOC:vw]", "GOMF_CYTOSKELETON_NUCLEAR_MEMBRANE_ANCHOR_ACTIVITY": "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane. [PMID:16237665]", "GOMF_CYTOSKELETAL_MOTOR_ACTIVITY": "Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]", "GOMF_C_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. [GOC:ai]", "GOMF_C_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. [GOC:ai]", "GOMF_C_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. [GOC:ai]", "GOMF_C_C_CHEMOKINE_BINDING": "Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]", "GOMF_C_X3_C_CHEMOKINE_BINDING": "Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]", "GOMF_CYTOSKELETAL_PROTEIN_BINDING": "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). [GOC:mah]", "GOMF_C_PALMITOYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. [GOC:ai]", "GOMF_C_X_C_CHEMOKINE_BINDING": "Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:ai]", "GOMF_D1_DOPAMINE_RECEPTOR_BINDING": "Binding to a D1 dopamine receptor. [GOC:mah, GOC:nln]", "GOMF_C_X_C_CHEMOKINE_RECEPTOR_ACTIVITY": "Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:signaling, PMID:8662823]", "GOMF_DAMAGED_DNA_BINDING": "Binding to damaged DNA. [GOC:jl]", "GOMF_DEACETYLASE_ACTIVITY": "Catalysis of the hydrolysis of an acetyl group from a substrate molecule. [GOC:jl]", "GOMF_DEAD_H_BOX_RNA_HELICASE_BINDING": "Binding to a DEAD/H-box RNA helicase. [GOC:jl]", "GOMF_DEAMINASE_ACTIVITY": "Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R). [GOC:jl]", "GOMF_DEATH_RECEPTOR_ACTIVITY": "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]", "GOMF_DEATH_DOMAIN_BINDING": "Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB. [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]", "GOMF_DEATH_RECEPTOR_BINDING": "Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). [GOC:ceb, GOC:rl, PMID:15654015]", "GOMF_DEHYDROASCORBIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other. [GOC:go_curators]", "GOMF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513]", "GOMF_DELTA_CATENIN_BINDING": "Binding to the delta subunit of the catenin complex. [GOC:rph]", "GOMF_DENEDDYLASE_ACTIVITY": "An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. [GOC:mah, PMID:25628956]", "GOMF_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a substrate. [GOC:mah]", "GOMF_DEOXYNUCLEOSIDE_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. [EC:2.7.1.145]", "GOMF_DESUMOYLASE_ACTIVITY": "An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated. [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250, PMID:23746258]", "GOMF_DEOXYRIBONUCLEASE_I_ACTIVITY": "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. [EC:3.1.21.1]", "GOMF_DEUBIQUITINASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a deubiquitinase. [GOC:sart, ISBN:0120793709]", "GOMF_DIACYLGLYCEROL_BINDING": "Binding to a diacylglycerol, a diester of glycerol and two fatty acids. [GOC:ma]", "GOMF_DEUBIQUITINASE_ACTIVITY": "An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:mec, PMID:30783221]", "GOMF_DIACYLGLYCEROL_DEPENDENT_SERINE_THREONINE_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. [EC:2.7.11.13]", "GOMF_DIACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. [EC:2.3.1.20]", "GOMF_DIHYDROPYRIMIDINASE_ACTIVITY": "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. [EC:3.5.2.2]", "GOMF_DINUCLEOTIDE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. [PMID:2848456, PMID:4405504]", "GOMF_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. [GOC:ai]", "GOMF_DIPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a dipeptide. [EC:3.4.13.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]", "GOMF_DIPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. [GOC:mah]", "GOMF_DIOXYGENASE_ACTIVITY": "Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. [PMID:1444267]", "GOMF_DIPEPTIDYL_PEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]", "GOMF_DIPHOSPHOTRANSFERASE_ACTIVITY": "", "GOMF_DISORDERED_DOMAIN_SPECIFIC_BINDING": "Binding to a disordered domain of a protein. [GOC:gg, PMID:11746698]", "GOMF_DISACCHARIDE_BINDING": "Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units. [GOC:jid]", "GOMF_DNA_APURINIC_OR_APYRIMIDINIC_SITE_ENDONUCLEASE_ACTIVITY": "Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). [Wikipedia:AP_endonuclease]", "GOMF_DISULFIDE_OXIDOREDUCTASE_ACTIVITY": "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. [GOC:curators]", "GOMF_DNA_BINDING_BENDING": "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]", "GOMF_DNA_CLAMP_LOADER_ACTIVITY": "Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis. [GOC:mah, GOC:vw, PMID:16082778]", "GOMF_DNA_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule. [GOC:bf]", "GOMF_DNA_DAMAGE_SENSOR_ACTIVITY": "A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response. [PMID:31995034]", "GOMF_DNA_BINDING_TRANSCRIPTION_REPRESSOR_ACTIVITY": "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. [GOC:txnOH-2018]", "GOMF_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY": "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. [EC:2.7.7.7, GOC:vw]", "GOMF_DNA_DNA_ANNEALING_ACTIVITY": "An activity that facilitates the formation of a complementary double-stranded DNA molecule. [PMID:22888405, PMID:25520186]", "GOMF_DNA_BINDING_TRANSCRIPTION_ACTIVATOR_ACTIVITY": "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. [GOC:txnOH-2018]", "GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY": "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]", "GOMF_DNA_BINDING_TRANSCRIPTION_FACTOR_BINDING": "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]", "GOMF_DNA_DNA_TETHERING_ACTIVITY": "Bridging together two regions of a DNA molecule. [PMID:29358048, PMID:30626735]", "GOMF_DNA_ENDONUCLEASE_ACTIVITY_PRODUCING_3_PHOSPHOMONOESTERS": "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. [GOC:ai]", "GOMF_DNA_EXONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. [GOC:mah, ISBN:0198547684]", "GOMF_DNA_ENDONUCLEASE_ACTIVITY": "Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks. [GOC:mah, ISBN:0198547684]", "GOMF_DNA_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group to a DNA molecule. [GOC:jl, ISBN:0198506732, PMID:7862522]", "GOMF_DNA_INSERTION_OR_DELETION_BINDING": "Binding to a double-stranded DNA region containing an insertion or a deletion. [GOC:vk]", "GOMF_DNA_N_GLYCOSYLASE_ACTIVITY": "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. [GOC:elh, PMID:11554296]", "GOMF_DNA_HELICASE_ACTIVITY": "Unwinding of a DNA helix, driven by ATP hydrolysis. [GOC:jl]", "GOMF_DNA_NUCLEASE_ACTIVITY": "Catalysis of the cleavage of ester linkages within deoxyribonucleic acid. [GOC:mah, ISBN:0198547684]", "GOMF_DNA_POLYMERASE_ACTIVITY": "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1). [RHEA:22508]", "GOMF_DNA_POLYMERASE_BINDING": "Binding to a DNA polymerase. [GOC:BHF, GOC:mah]", "GOMF_DNA_REPLICATION_ORIGIN_BINDING": "Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. [GOC:curators]", "GOMF_DNA_RNA_HYBRID_BINDING": "Binding to a RNA/DNA hybrid. [GOC:ecd]", "GOMF_DNA_TOPOISOMERASE_ACTIVITY": "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. [GOC:mah, PMID:8811192]", "GOMF_DNA_TRANSLOCASE_ACTIVITY": "Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis. [GOC:mah, PMID:16428451, PMID:17631491]", "GOMF_DNA_SECONDARY_STRUCTURE_BINDING": "Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction. [GOC:krc]", "GOMF_DOLICHYL_PHOSPHATE_MANNOSE_PROTEIN_MANNOSYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. [EC:2.4.1.109, GOC:pr]", "GOMF_DOPAMINE_BINDING": "Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. [ISBN:0198506732]", "GOMF_DOPAMINE_NEUROTRANSMITTER_RECEPTOR_ACTIVITY": "Combining with the neurotransmitter dopamine to initiate a change in cell activity. [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983]", "GOMF_DOUBLE_STRANDED_DNA_3_5_DNA_EXONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. [GOC:mah, PMID:22562358]", "GOMF_DOUBLE_STRANDED_DNA_EXODEOXYRIBONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. [GOC:mah]", "GOMF_DOPAMINE_RECEPTOR_BINDING": "Binding to a dopamine receptor. [GOC:ai]", "GOMF_DOUBLE_STRANDED_METHYLATED_DNA_BINDING": "Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. [GOC:imk, PMID:17242155]", "GOMF_DOUBLE_STRANDED_RNA_ADENOSINE_DEAMINASE_ACTIVITY": "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. [GOC:mah, RHEA:10120]", "GOMF_DYNACTIN_BINDING": "Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity. [GOC:BHF, GOC:mah]", "GOMF_DOUBLE_STRANDED_TELOMERIC_DNA_BINDING": "Binding to double-stranded telomere-associated DNA. [GOC:jl, ISBN:0321000382]", "GOMF_DOUBLE_STRANDED_RNA_BINDING": "Binding to double-stranded RNA. [GOC:jl]", "GOMF_DYNEIN_COMPLEX_BINDING": "Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. [GOC:bf, GOC:BHF, GOC:mah]", "GOMF_DYNEIN_HEAVY_CHAIN_BINDING": "Binding to a heavy chain of the dynein complex. [GOC:bf]", "GOMF_DYNEIN_INTERMEDIATE_CHAIN_BINDING": "Binding to an intermediate chain of the dynein complex. [GOC:bf]", "GOMF_DYNEIN_LIGHT_INTERMEDIATE_CHAIN_BINDING": "Binding to a light intermediate chain of the dynein complex. [GOC:bf]", "GOMF_DYNEIN_LIGHT_CHAIN_BINDING": "Binding to a light chain of the dynein complex. [GOC:bf]", "GOMF_DYSTROGLYCAN_BINDING": "Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal). [GOC:hjd]", "GOMF_D_LOOP_DNA_BINDING": "Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind. [PMID:20924116]", "GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_ELECTRON_TRANSFER_ACTIVITY": "A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer]", "GOMF_ENDONUCLEASE_ACTIVITY": "Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. [GOC:mah, ISBN:0198547684]", "GOMF_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS": "", "GOMF_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS": "", "GOMF_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS": "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. [GOC:mah]", "GOMF_ENDOPEPTIDASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of an endopeptidase. [GOC:dph, GOC:tb]", "GOMF_ENDOPOLYPHOSPHATASE_ACTIVITY": "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. [EC:3.6.1.10]", "GOMF_ENONE_REDUCTASE_ACTIVITY": "Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+. [GOC:kad, PMID:17945329, PMID:19166903]", "GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. [GOC:dph, GOC:tb]", "GOMF_ENOYL_COA_HYDRATASE_ACTIVITY": "Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O. [EC:4.2.1.17]", "GOMF_ENDOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]", "GOMF_EPHRIN_RECEPTOR_ACTIVITY": "Combining with an ephrin receptor ligand to initiate a change in cell activity. [GOC:mah, PMID:9530499]", "GOMF_EPHRIN_RECEPTOR_BINDING": "Binding to an ephrin receptor. [GOC:ai]", "GOMF_ENZYME_ACTIVATOR_ACTIVITY": "A molecular function regulator that increases a catalytic activity. [GOC:pdt]", "GOMF_ENZYME_SUBSTRATE_ADAPTOR_ACTIVITY": "An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity. [PMID:16250895, PMID:34358446]", "GOMF_EPINEPHRINE_BINDING": "Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:ai]", "GOMF_EPOXIDE_HYDROLASE_ACTIVITY": "Catalysis of the reaction: an epoxide + H2O = an ethanediol. [EC:3.3.2.10]", "GOMF_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to an epidermal growth factor receptor. [GOC:ai]", "GOMF_ENZYME_INHIBITOR_ACTIVITY": "A molecular function regulator that reduces a catalytic activity. [GOC:ai, GOC:ebc]", "GOMF_ERBB_3_CLASS_RECEPTOR_BINDING": "Binding to the protein-tyrosine kinase receptor ErbB-3/HER3. [GOC:jl]", "GOMF_ER_RETENTION_SEQUENCE_BINDING": "Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. [GOC:ai]", "GOMF_ENZYME_REGULATOR_ACTIVITY": "A molecular function regulator that modulates a catalytic activity. [GOC:pdt]", "GOMF_ESTRADIOL_17_BETA_DEHYDROGENASE_NAD_P_ACTIVITY": "", "GOMF_ESTROGEN_RESPONSE_ELEMENT_BINDING": "Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005]", "GOMF_ESTROGEN_16_ALPHA_HYDROXYLASE_ACTIVITY": "Catalysis of the reaction: estrogen + reduced [NADPH--hemoprotein reductase] + O2 = 16-alpha-hydroxyestrogen + oxidized [NADPH--hemoprotein reductase] + H2O. [GOC:BHF]", "GOMF_ESTROGEN_2_HYDROXYLASE_ACTIVITY": "Catalysis of the reaction: estrogen + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxyestrogen + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:BHF, GOC:rl, PMID:14559847]", "GOMF_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_2ALPHA_KINASE_ACTIVITY": "", "GOMF_EUKARYOTIC_INITIATION_FACTOR_4E_BINDING": "Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. [ISBN:0198506732]", "GOMF_EXOGENOUS_PROTEIN_BINDING": "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein. [PMID:28861068]", "GOMF_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_MONOATOMIC_ION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. [GOC:mah, ISBN:0323037070]", "GOMF_EXONUCLEASE_ACTIVITY": "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. [GOC:mah, ISBN:0198547684]", "GOMF_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS": "", "GOMF_EXTRACELLULARLY_ATP_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:bf, GOC:mah, PMID:9755289]", "GOMF_EXOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. [https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]", "GOMF_EXTRACELLULAR_LIGAND_GATED_MONOATOMIC_ION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_EXTRACELLULAR_MATRIX_CONSTITUENT_CONFERRING_ELASTICITY": "A component of the extracellular matrix that enables the matrix to recoil after transient stretching. [GOC:mah, ISBN:0815316194]", "GOMF_EXTRACELLULAR_MATRIX_PROTEIN_BINDING": "Binding to a protein that is part of an extracellular matrix. [PMID:22355679]", "GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT_CONFERRING_COMPRESSION_RESISTANCE": "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. [GOC:mah, ISBN:0815316194]", "GOMF_EXTRACELLULAR_MATRIX_BINDING": "Binding to a component of the extracellular matrix. [GOC:ai]", "GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT": "The action of a molecule that contributes to the structural integrity of the extracellular matrix. [GOC:mah]", "GOMF_E_BOX_BINDING": "Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. [GOC:BHF, GOC:vk, PMID:11812799]", "GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT_CONFERRING_TENSILE_STRENGTH": "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress. [GOC:mah, ISBN:0815316194]", "GOMF_FAD_BINDING": "Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]", "GOMF_FATTY_ACID_BINDING": "Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]", "GOMF_FATTY_ACID_ELONGASE_ACTIVITY": "Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. [PMID:16564093, PMID:19763486, RHEA:32727]", "GOMF_FATTY_ACID_OMEGA_HYDROXYLASE_ACTIVITY": "Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:krc, RHEA:39023]", "GOMF_FATTY_ACID_DERIVATIVE_BINDING": "Binding to fatty acid derivative. [GOC:pr, GOC:TermGenie]", "GOMF_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]", "GOMF_FATTY_ACYL_COA_SYNTHASE_ACTIVITY": "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. [EC:2.3.1.86]", "GOMF_FATZ_BINDING": "Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. [PMID:10984498, PMID:11699871]", "GOMF_FERRIC_IRON_BINDING": "Binding to a ferric iron ion, Fe(III). [GOC:ai]", "GOMF_FERROUS_IRON_BINDING": "Binding to a ferrous iron ion, Fe(II). [GOC:ai]", "GOMF_FERROUS_IRON_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. [ISBN:0198506732]", "GOMF_FIBRINOGEN_BINDING": "Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade. [GOC:BHF, GOC:mah, GOC:vk]", "GOMF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_ACTIVITY": "Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]", "GOMF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to a fibroblast growth factor receptor (FGFR). [GOC:ceb]", "GOMF_FIBROBLAST_GROWTH_FACTOR_BINDING": "Binding to a fibroblast growth factor. [PMID:9806903]", "GOMF_FIBRONECTIN_BINDING": "Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. [GOC:hjd]", "GOMF_FILAMIN_BINDING": "Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. [GOC:mah, PMID:11336782]", "GOMF_FLAP_ENDONUCLEASE_ACTIVITY": "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. [GOC:jid]", "GOMF_FK506_BINDING": "Binding to a 23-membered macrolide lactone FK506. [GOC:jl]", "GOMF_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING": "Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]", "GOMF_FLIPPASE_ACTIVITY": "Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. [PMID:20043909, PMID:25284293, Wikipedia:Flippase]", "GOMF_FLOPPASE_ACTIVITY": "Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP. [PMID:20043909, PMID:25284293, Wikipedia:Flippase]", "GOMF_FMN_BINDING": "Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:tb]", "GOMF_FOLIC_ACID_BINDING": "Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:jl, ISBN:0198506732]", "GOMF_FOLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:ai]", "GOMF_FOUR_WAY_JUNCTION_DNA_BINDING": "Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. [GOC:krc, ISBN:0815332181, PMID:15563464]", "GOMF_FOUR_WAY_JUNCTION_HELICASE_ACTIVITY": "Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. [GOC:al, PMID:22723423, PMID:9442895]", "GOMF_FRUCTOSE_6_PHOSPHATE_BINDING": "", "GOMF_FRUCTOSE_BINDING": "Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose. [CHEBI:28757, GOC:BHF, GOC:mah]", "GOMF_FRIZZLED_BINDING": "Binding to a frizzled (fz) receptor. [GOC:ceb]", "GOMF_FRUCTOSE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_FRUCTOSE_2_6_BISPHOSPHATE_2_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. [EC:3.1.3.46]", "GOMF_GABA_A_RECEPTOR_ACTIVITY": "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. [PMID:8974333]", "GOMF_FUCOSE_BINDING": "Binding to fucose, the pentose 6-deoxygalactose. [ISBN:0582227089]", "GOMF_FUCOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]", "GOMF_GABA_RECEPTOR_BINDING": "Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. [GOC:ai]", "GOMF_GABA_RECEPTOR_ACTIVITY": "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. [GOC:jl, GOC:signaling, PMID:10637650]", "GOMF_GALACTOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. [GOC:ai]", "GOMF_GALACTOSIDE_BINDING": "Binding to a glycoside in which the sugar group is galactose. [GOC:jl, ISBN:0198506732]", "GOMF_GALACTOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [ISBN:0198506732]", "GOMF_GAMMA_AMINOBUTYRIC_ACID_SODIUM_CHLORIDE_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). [PMID:7589472, PMID:7861179]", "GOMF_GALACTOSYLCERAMIDASE_ACTIVITY": "", "GOMF_GAMMA_CATENIN_BINDING": "Binding to catenin complex gamma subunit. [GOC:bf]", "GOMF_GAMMA_AMINOBUTYRIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]", "GOMF_GANGLIOSIDE_BINDING": "Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues. [GOC:yaf]", "GOMF_GAMMA_TUBULIN_BINDING": "Binding to the microtubule constituent protein gamma-tubulin. [GOC:jl]", "GOMF_GAP_JUNCTION_CHANNEL_ACTIVITY_INVOLVED_IN_CARDIAC_CONDUCTION_ELECTRICAL_COUPLING": "A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOMF_GAP_JUNCTION_CHANNEL_ACTIVITY": "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]", "GOMF_GAP_JUNCTION_CHANNEL_ACTIVITY_INVOLVED_IN_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING": "Any gap junction channel activity that is involved in cell communication by electrical coupling. [GO_REF:0000061, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:24587307]", "GOMF_GAP_JUNCTION_HEMI_CHANNEL_ACTIVITY": "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. [GOC:dgh]", "GOMF_GDP_BINDING": "Binding to GDP, guanosine 5'-diphosphate. [GOC:ai]", "GOMF_GDP_DISSOCIATION_INHIBITOR_ACTIVITY": "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. [GOC:mah]", "GOMF_GDP_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: GDP + H2O = GMP + phosphate. [PMID:2989286, RHEA:22156]", "GOMF_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_BINDING": "Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation. [GOC:txnOH-2018]", "GOMF_GLUCOSE_BINDING": "", "GOMF_GATED_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. [GOC:mtg_transport]", "GOMF_GLIAL_CELL_DERIVED_NEUROTROPHIC_FACTOR_RECEPTOR_ACTIVITY": "Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]", "GOMF_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY": "A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. [GOC:txnOH-2018]", "GOMF_GLUCOSE_SODIUM_SYMPORTER_ACTIVITY": "", "GOMF_GLUCOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. [ISBN:0198506732]", "GOMF_GLUCOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [ISBN:0198506732]", "GOMF_GLUCURONOSYL_N_ACETYLGALACTOSAMINYL_PROTEOGLYCAN_4_BETA_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. [EC:2.4.1.175]", "GOMF_GLUCURONOSYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H+ + UDP. [RHEA:21032]", "GOMF_GLUTAMATE_BINDING": "Binding to glutamate, the anion of 2-aminopentanedioic acid. [GOC:ai]", "GOMF_GLUTAMATE_GATED_CALCIUM_ION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_GLUTAMATE_RECEPTOR_ACTIVITY": "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]", "GOMF_GLUTATHIONE_DISULFIDE_OXIDOREDUCTASE_ACTIVITY": "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. [GOC:mah]", "GOMF_GLUTAMATE_GATED_RECEPTOR_ACTIVITY": "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [ISBN:0198506732]", "GOMF_GLUTAMATE_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). [TC:2.A.27.1.1]", "GOMF_GLUTATHIONE_HYDROLASE_ACTIVITY": "Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. [EC:3.4.19.13, GOC:imk]", "GOMF_GLUTAMATE_RECEPTOR_BINDING": "Binding to a glutamate receptor. [GOC:bf]", "GOMF_GLUTATHIONE_PEROXIDASE_ACTIVITY": "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. [EC:1.11.1.9, PMID:36771108]", "GOMF_GLUTATHIONE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other. [GOC:mah]", "GOMF_GLUTATHIONE_TRANSFERASE_ACTIVITY": "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. [EC:2.5.1.18]", "GOMF_GLYCEROL_3_PHOSPHATE_O_ACYLTRANSFERASE_ACTIVITY": "", "GOMF_GLYCERALDEHYDE_3_PHOSPHATE_DEHYDROGENASE_NADPLUS_NON_PHOSPHORYLATING_ACTIVITY": "", "GOMF_GLYCEROL_CHANNEL_ACTIVITY": "Enables the energy-independent facilitated diffusion of glycerol through a transmembrane aqueous pore or channel. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_GLYCEROL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:ai]", "GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY": "Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. [PMID:26212235]", "GOMF_GLYCEROPHOSPHODIESTER_PHOSPHODIESTERASE_ACTIVITY": "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. [EC:3.1.4.46]", "GOMF_GLYCOGEN_BINDING": "Binding to glycogen. [GOC:mengo_curators]", "GOMF_GLYCINE_N_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN]", "GOMF_GLYCINE_BINDING": "Binding to glycine, aminoethanoic acid. [GOC:ai]", "GOMF_GLYCINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. [GOC:ai]", "GOMF_GLYCOLIPID_BINDING": "Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. [PMID:19635802]", "GOMF_GLYCOLIPID_MANNOSYLTRANSFERASE_ACTIVITY": "", "GOMF_GLYCOSPHINGOLIPID_BINDING": "Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:jl]", "GOMF_GPI_ANCHOR_BINDING": "Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. [GOC:vw]", "GOMF_GLYCOSAMINOGLYCAN_BINDING": "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. [GOC:jl, ISBN:0198506732]", "GOMF_GPI_LINKED_EPHRIN_RECEPTOR_ACTIVITY": "Combining with a GPI-anchored ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]", "GOMF_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to a growth factor receptor. [GOC:mah, GOC:vw]", "GOMF_GLYCOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]", "GOMF_GTPASE_ACTIVATING_PROTEIN_BINDING": "Binding to a GTPase activating protein. [GOC:nln]", "GOMF_GROWTH_HORMONE_RECEPTOR_BINDING": "Binding to a growth hormone receptor. [GOC:ai]", "GOMF_GROWTH_FACTOR_BINDING": "Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. [GOC:curators]", "GOMF_GROWTH_FACTOR_ACTIVITY": "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]", "GOMF_GTPASE_INHIBITOR_ACTIVITY": "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. [GOC:ai]", "GOMF_GTPASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]", "GOMF_GTP_DEPENDENT_PROTEIN_BINDING": "Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state. [GOC:go_curators, GOC:krc]", "GOMF_GUANYLATE_CYCLASE_ACTIVITY": "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. [EC:4.6.1.2]", "GOMF_GTPASE_ACTIVITY": "Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. [PMID:26832457, PMID:27218782]", "GOMF_GTPASE_BINDING": "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP. [GOC:ai]", "GOMF_GUANYLATE_CYCLASE_REGULATOR_ACTIVITY": "Modulates the activity of guanylate cyclase. [GOC:mah]", "GOMF_GUANINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other. [GOC:mcc]", "GOMF_GUANYLYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a guanylyl group to an acceptor. [GOC:mah]", "GOMF_GUANYLATE_KINASE_ACTIVITY": "", "GOMF_GUANYL_RIBONUCLEOTIDE_BINDING": "", "GOMF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY": "Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]", "GOMF_G_PROTEIN_ACTIVITY": "A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). [PMID:16923326, PMID:24470015]", "GOMF_G_PROTEIN_ALPHA_SUBUNIT_BINDING": "Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. [GOC:hjd]", "GOMF_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_ACTIVITY": "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:fj, GOC:mah]", "GOMF_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING": "Binding to a complex of G-protein beta/gamma subunits. [GOC:nln, GOC:vw]", "GOMF_G_PROTEIN_BETA_SUBUNIT_BINDING": "Binding to a G-protein beta subunit. [GOC:mah]", "GOMF_G_PROTEIN_COUPLED_ADENOSINE_RECEPTOR_ACTIVITY": "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah, PMID:9755289]", "GOMF_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY": "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah]", "GOMF_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY": "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph]", "GOMF_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_ACTIVITY": "Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity. [GOC:dos]", "GOMF_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_BINDING": "Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor). [GOC:bf, ISBN:0198506732, PMID:9069287]", "GOMF_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY": "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:fj, GOC:mah]", "GOMF_G_PROTEIN_COUPLED_OPIOID_RECEPTOR_ACTIVITY": "Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:ai, GOC:bf, PMID:20494127]", "GOMF_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_ACTIVITY": "Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, PMID:9755289]", "GOMF_G_PROTEIN_COUPLED_RECEPTOR_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate. [GOC:dph]", "GOMF_G_QUADRUPLEX_DNA_BINDING": "Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. [PMID:16142245, PMID:9512530]", "GOMF_G_PROTEIN_COUPLED_SEROTONIN_RECEPTOR_ACTIVITY": "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai]", "GOMF_G_QUADRUPLEX_RNA_BINDING": "Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. [PMID:18294969, PMID:18568163, PMID:19330720]", "GOMF_G_RICH_STRAND_TELOMERIC_DNA_BINDING": "Binding to G-rich, single-stranded, telomere-associated DNA. [PMID:11349150]", "GOMF_G_PROTEIN_COUPLED_RECEPTOR_BINDING": "Binding to a G protein-coupled receptor. [GOC:ceb, GOC:dph]", "GOMF_HAPTOGLOBIN_BINDING": "", "GOMF_HELICASE_ACTIVITY": "", "GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY": "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, Wikipedia:GPCR]", "GOMF_HEAT_SHOCK_PROTEIN_BINDING": "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. [GOC:mah, GOC:vw]", "GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of heme from one side of a membrane to the other. [PMID:29549126]", "GOMF_HEMOGLOBIN_BINDING": "Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:jl]", "GOMF_HEPARAN_SULFATE_BINDING": "Binding to heparan sulfate. [GO_REF:0000067, GOC:TermGenie, PMID:8567685]", "GOMF_HEMOGLOBIN_ALPHA_BINDING": "Binding to a hemoglobin alpha chain. [GOC:mah]", "GOMF_HEPARAN_SULFATE_GLUCOSAMINE_3_SULFOTRANSFERASE_1_ACTIVITY": "", "GOMF_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING": "Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. [ISBN:0198506732]", "GOMF_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. [GOC:mah]", "GOMF_HEXOKINASE_ACTIVITY": "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. [EC:2.7.1.1]", "GOMF_HEXOSAMINIDASE_ACTIVITY": "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. [ISBN:0721662544]", "GOMF_HETEROTRIMERIC_G_PROTEIN_BINDING": "Binding to a heterotrimeric G-protein. [GOC:nln]", "GOMF_HEPARIN_BINDING": "Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]", "GOMF_HEXOSE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]", "GOMF_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_BINDING": "Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. [GOC:mah]", "GOMF_HISTONE_ACETYLTRANSFERASE_BINDING": "Binding to an histone acetyltransferase. [GOC:bf]", "GOMF_HISTAMINE_RECEPTOR_ACTIVITY": "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]", "GOMF_HISTONE_CHAPERONE_ACTIVITY": "Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone). [PMID:26459557]", "GOMF_HEXOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). [EC:2.4.1.-]", "GOMF_HISTONE_DEACETYLASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of histone deacetylase. [GOC:bf]", "GOMF_HISTONE_DEACETYLASE_BINDING": "Binding to histone deacetylase. [GOC:jl]", "GOMF_HISTONE_BINDING": "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]", "GOMF_HISTONE_DECROTONYLASE_ACTIVITY": "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]. [PMID:28497810]", "GOMF_HISTONE_DEUBIQUITINASE_ACTIVITY": "A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated. [PMID:18206972, PMID:18226187]", "GOMF_HISTONE_H2A_UBIQUITIN_LIGASE_ACTIVITY": "Catalysis of the transfer of ubiquitin to a histone H2A substrate. [PMID:25303536]", "GOMF_HISTONE_H2A_DEUBIQUITINASE_ACTIVITY": "A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated. [PMID:18226187, PMID:20436459]", "GOMF_HISTONE_H2AX_KINASE_ACTIVITY": "Catalysis of the transfer of a phosphate group to a histone variant H2AX. [GOC:bf]", "GOMF_HISTONE_H3K14_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14). [GOC:vw, PMID:18552846, PMID:19056256, PMID:21289066]", "GOMF_HISTONE_H3K27ME2_H3K27ME3_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [GOC:sp, PMID:20622853]", "GOMF_HISTONE_H3K27_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein. [GOC:ai]", "GOMF_HISTONE_H3K36_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16362057]", "GOMF_HISTONE_H3K36_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein. [GOC:ai]", "GOMF_HISTONE_H3K36_TRIMETHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3. [RHEA:60324]", "GOMF_HISTONE_H3K4ME_H3K4ME2_H3K4ME3_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17550896, PMID:22473470]", "GOMF_HISTONE_H3K4_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein. [PMID:12086618]", "GOMF_HISTONE_H3K4_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein. [GOC:mah]", "GOMF_HISTONE_H3K4_MONOMETHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me. [RHEA:60264]", "GOMF_HISTONE_H3K4_TRIMETHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3. [PMID:18375658, RHEA:60260]", "GOMF_HISTONE_H3K9ME2_H3K9ME3_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:20208542, PMID:20531378]", "GOMF_HISTONE_H3K9ME2_METHYLTRANSFERASE_ACTIVITY": "", "GOMF_HISTONE_H3K9ME_H3K9ME2_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16603238]", "GOMF_HISTONE_H3K9_MONOMETHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me. [RHEA:60280]", "GOMF_HISTONE_H3K9_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein. [PMID:16362057]", "GOMF_HISTONE_H3K9_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein. [GOC:ai]", "GOMF_HISTONE_H3K9_TRIMETHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3. [RHEA:60276]", "GOMF_HISTONE_H3_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3. [PMID:19056256]", "GOMF_HISTONE_H3_KINASE_ACTIVITY": "Catalysis of the transfer of a phosphate group to a histone H3. [PMID:25303536]", "GOMF_HISTONE_H4K12_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). [PMID:18552846, PMID:19056256]", "GOMF_HISTONE_H3_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue. [PMID:28450737]", "GOMF_HISTONE_H4K16_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4. [PMID:18552846, PMID:19056256]", "GOMF_HISTONE_H4K20_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein. [PMID:12086618]", "GOMF_HISTONE_H4K5_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5). [PMID:18552846, PMID:19056256]", "GOMF_HISTONE_H4K20_MONOMETHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-lysyl20-[histone H4] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me. [RHEA:60344]", "GOMF_HISTONE_H4_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. [PMID:19056256]", "GOMF_HISTONE_H4_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17947579]", "GOMF_HISTONE_H4_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue. [PMID:28450737]", "GOMF_HISTONE_KINASE_ACTIVITY": "Catalysis of the transfer of a phosphate group to a histone. [GOC:bf]", "GOMF_HISTONE_METHYLTRANSFERASE_BINDING": "Binding to a histone methyltransferase enzyme. [GOC:ame, GOC:BHF, PMID:19486527]", "GOMF_HISTONE_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue. [GOC:curators]", "GOMF_HISTONE_UBIQUITIN_LIGASE_ACTIVITY": "Catalysis of the transfer of ubiquitin to a histone substrate. [GOC:curators]", "GOMF_HMG_BOX_DOMAIN_BINDING": "Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. [GOC:yaf, InterPro:IPR009071, PMID:18445004]", "GOMF_HISTONE_READER_ACTIVITY": "A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. [PMID:11498575, PMID:25688442, PMID:31082667, PMID:34726351]", "GOMF_HORMONE_ACTIVITY": "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. [GOC:dph, GOC:mah, ISBN:0198506732]", "GOMF_HISTONE_MODIFYING_ACTIVITY": "A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression. [GOC:pg]", "GOMF_HORMONE_RECEPTOR_BINDING": "Binding to a receptor for a hormone. [GOC:ai]", "GOMF_HORMONE_BINDING": "Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor. [GOC:jl]", "GOMF_HYALURONIC_ACID_BINDING": "Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. [GOC:jl]", "GOMF_HSP90_PROTEIN_BINDING": "Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. [GOC:ai]", "GOMF_HYALURONONGLUCOSAMINIDASE_ACTIVITY": "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. [EC:3.2.1.35]", "GOMF_HSP70_PROTEIN_BINDING": "Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDES": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. [EC:3.5.2.-]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS": "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. [EC:3.5.-.-]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. [EC:3.5.3.-]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. [EC:3.5.4.-]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES": "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. [EC:3.5.1.-]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS": "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. [GOC:ai, GOC:jl]", "GOMF_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS": "Catalysis of the hydrolysis of any N-glycosyl bond. [GOC:jl]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES": "Catalysis of the hydrolysis of any acid anhydride. [GOC:jl]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS": "Catalysis of the hydrolysis of any glycosyl bond. [GOC:jl]", "GOMF_HYDROPEROXY_ICOSATETRAENOATE_DEHYDRATASE_ACTIVITY": "A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O. [PMID:12881489, RHEA:55556]", "GOMF_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS": "Catalysis of the hydrolysis of any O-glycosyl bond. [GOC:mah]", "GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS": "Catalysis of the hydrolysis of any ester bond. [GOC:jl]", "GOMF_ICOSANOID_BINDING": "Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids. [ISBN:0198506732]", "GOMF_HYDROXYMETHYL_FORMYL_AND_RELATED_TRANSFERASE_ACTIVITY": "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). [EC:2.1.2.-, GOC:mah]", "GOMF_HYDRO_LYASE_ACTIVITY": "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. [EC:4.2.1.-]", "GOMF_ICOSANOID_RECEPTOR_ACTIVITY": "Combining with an icosanoid to initiate a change in cell activity. [GOC:dph]", "GOMF_ICOSANOID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of icosanoids from one side of a membrane to the other. [GOC:sl]", "GOMF_IGE_BINDING": "Binding to an immunoglobulin of the IgE isotype. [GOC:add, ISBN:0781735149]", "GOMF_IGG_BINDING": "Binding to an immunoglobulin of an IgG isotype. [GOC:add, ISBN:0781735149]", "GOMF_IGG_RECEPTOR_ACTIVITY": "Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]", "GOMF_IMMUNOGLOBULIN_BINDING": "Binding to an immunoglobulin. [GOC:ma]", "GOMF_IMMUNOGLOBULIN_RECEPTOR_ACTIVITY": "Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, ISBN:0198547684]", "GOMF_IMMUNOGLOBULIN_RECEPTOR_BINDING": "Binding to one or more specific sites on an immunoglobulin receptor molecule. [GOC:BHF, GOC:vk]", "GOMF_IMPORTIN_ALPHA_FAMILY_PROTEIN_BINDING": "Binding to a member of the importin-alpha family. [PMID:15350979, PMID:17170104, PMID:23734157]", "GOMF_IMMUNE_RECEPTOR_ACTIVITY": "Receiving a signal and transmitting it in a cell to initiate an immune response. [PMID:31415752, Wikipedia:Immune_receptor]", "GOMF_INITIATOR_METHIONYL_AMINOPEPTIDASE_ACTIVITY": "Catalysis of the release of N-terminal initiator methionine from peptides. [EC:3.4.11.18]", "GOMF_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_INORGANIC_DIPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. [EC:3.6.1.1, RHEA:24576]", "GOMF_INHIBITORY_MHC_CLASS_I_RECEPTOR_ACTIVITY": "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134]", "GOMF_INORGANIC_MOLECULAR_ENTITY_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_INOSITOL_1_3_4_5_6_PENTAKISPHOSPHATE_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. [GOC:elh, PMID:11311242]", "GOMF_INOSITOL_1_3_4_5_TETRAKISPHOSPHATE_BINDING": "Binding to inositol 1,3,4,5 tetrakisphosphate. [GOC:go_curators]", "GOMF_INOSITOL_1_4_5_TRISPHOSPHATE_5_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. [RHEA:19797]", "GOMF_INOSITOL_1_4_5_TRISPHOSPHATE_BINDING": "Binding to inositol 1,4,5 trisphosphate. [GOC:BHF, GOC:mah]", "GOMF_INOSITOL_BISPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate. [GOC:hb]", "GOMF_INOSITOL_PHOSPHATE_KINASE_ACTIVITY": "Catalysis of the reaction: inositol phosphate + ATP = inositol phosphate + ADP. [PMID:35536002]", "GOMF_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. [GOC:ai]", "GOMF_INOSITOL_POLYPHOSPHATE_5_PHOSPHATASE_ACTIVITY": "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56]", "GOMF_INOSITOL_TETRAKISPHOSPHATE_KINASE_ACTIVITY": "", "GOMF_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. [GOC:ai]", "GOMF_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. [GOC:bf]", "GOMF_INSULIN_BINDING": "Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [ISBN:0198506732]", "GOMF_INSULIN_LIKE_GROWTH_FACTOR_II_BINDING": "Binding to insulin-like growth factor II. [GOC:mah]", "GOMF_INSULIN_LIKE_GROWTH_FACTOR_BINDING": "Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. [ISBN:0198506732]", "GOMF_INSULIN_LIKE_GROWTH_FACTOR_I_BINDING": "Binding to insulin-like growth factor I. [GOC:mah]", "GOMF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to an insulin-like growth factor receptor. [GOC:jl]", "GOMF_INSULIN_RECEPTOR_BINDING": "Binding to an insulin receptor. [GOC:ai]", "GOMF_INSULIN_RECEPTOR_SUBSTRATE_BINDING": "Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. [PMID:12829233]", "GOMF_INTEGRIN_BINDING_INVOLVED_IN_CELL_MATRIX_ADHESION": "Any integrin binding that occurs as part of the process of cell-matrix adhesion. [GOC:dos]", "GOMF_INTERLEUKIN_12_RECEPTOR_BINDING": "Binding to an interleukin-12 receptor. [GOC:ai]", "GOMF_INTERFERON_RECEPTOR_ACTIVITY": "Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling, PMID:9607096]", "GOMF_INTERLEUKIN_17_RECEPTOR_ACTIVITY": "Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:jl, GOC:signaling]", "GOMF_INTERLEUKIN_1_BINDING": "Binding to interleukin-1. [GOC:jl, ISBN:0198506732]", "GOMF_INTEGRIN_BINDING": "Binding to an integrin. [GOC:ceb]", "GOMF_INTERLEUKIN_1_RECEPTOR_BINDING": "Binding to an interleukin-1 receptor. [GOC:go_curators]", "GOMF_INTERLEUKIN_1_RECEPTOR_ACTIVITY": "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. [GOC:jl]", "GOMF_INTERLEUKIN_6_RECEPTOR_BINDING": "Binding to an interleukin-6 receptor. [GOC:ai]", "GOMF_INTERLEUKIN_2_RECEPTOR_BINDING": "Binding to an interleukin-2 receptor. [GOC:ai]", "GOMF_INTERMEDIATE_FILAMENT_BINDING": "Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. [ISBN:0198506732]", "GOMF_INTRACELLULARLY_CALCIUM_GATED_CHLORIDE_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, PMID:29236691]", "GOMF_INTRACELLULARLY_CAMP_ACTIVATED_CATION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]", "GOMF_INTRACELLULARLY_CGMP_ACTIVATED_CATION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]", "GOMF_INTRACELLULARLY_GATED_CALCIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]", "GOMF_INTRACELLULARLY_LIGAND_GATED_MONOATOMIC_ION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_INTRACILIARY_TRANSPORT_PARTICLE_B_BINDING": "Binding to an intraciliary transport particle B (IFT B) complex. [PMID:20889716]", "GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY": "Enables the transport of a lipid from a region of a membrane to a different region on the same membrane. [PMID:16828084]", "GOMF_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES": "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. [EC:5.3.1.-, GOC:jl]", "GOMF_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS": "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. [EC:5.3.3.-, GOC:mah]", "GOMF_INTRAMOLECULAR_PHOSPHOTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a phosphate group from one position to another within a single molecule. [GOC:mah]", "GOMF_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY": "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. [EC:5.3.-.-, GOC:curators]", "GOMF_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING": "Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within. [GOC:txnOH]", "GOMF_INTRAMOLECULAR_TRANSFERASE_ACTIVITY": "Catalysis of the transfer of a functional group from one position to another within a single molecule. [GOC:mah]", "GOMF_IODIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of iodide ions from one side of a membrane to the other. [GOC:ai]", "GOMF_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. [GOC:cb, GOC:mah, PMID:14977398]", "GOMF_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING": "Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. [GOC:bf, ISBN:0198506732]", "GOMF_IRON_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of iron (Fe) ions from one side of a membrane to the other. [GOC:ai]", "GOMF_ISOCITRATE_DEHYDROGENASE_NAD_P_PLUS_ACTIVITY": "Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H. [GOC:curators]", "GOMF_IRON_ION_BINDING": "Binding to an iron (Fe) ion. [GOC:ai]", "GOMF_JUN_KINASE_BINDING": "Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. [GOC:jl]", "GOMF_I_SMAD_BINDING": "Binding to an inhibitory SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]", "GOMF_JUN_KINASE_KINASE_KINASE_ACTIVITY": "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). [GOC:bf]", "GOMF_K48_LINKED_DEUBIQUITINASE_ACTIVITY": "Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin. [GOC:bf, GOC:PARL, PMID:22970133]", "GOMF_K48_LINKED_POLYUBIQUITIN_MODIFICATION_DEPENDENT_PROTEIN_BINDING": "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein. [GOC:al, PMID:20739285]", "GOMF_ISOPRENOID_BINDING": "Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [GOC:jl]", "GOMF_K63_LINKED_DEUBIQUITINASE_ACTIVITY": "Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin. [GOC:dph, GOC:pg, PMID:18313383]", "GOMF_K63_LINKED_POLYUBIQUITIN_MODIFICATION_DEPENDENT_PROTEIN_BINDING": "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein. [GOC:mah, PMID:15556404, PMID:17525341]", "GOMF_ISOMERASE_ACTIVITY": "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [ISBN:0198506732]", "GOMF_KAINATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY": "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. [GOC:mah, PMID:10049997, PMID:8804111]", "GOMF_KETOSTEROID_MONOOXYGENASE_ACTIVITY": "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN]", "GOMF_KERATIN_FILAMENT_BINDING": "Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. [GOC:krc, PMID:6170061]", "GOMF_KINASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a kinase. [GOC:mah]", "GOMF_KINASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]", "GOMF_KINESIN_BINDING": "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. [GOC:curators, PMID:8606779]", "GOMF_KINETOCHORE_BINDING": "Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached. [GOC:jl]", "GOMF_LACTATE_DEHYDROGENASE_ACTIVITY": "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. [GOC:ai, GOC:bf]", "GOMF_LAMININ_1_BINDING": "Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. [GOC:go_curators]", "GOMF_KINASE_BINDING": "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]", "GOMF_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. [GOC:ai, ISBN:0198506732]", "GOMF_KINASE_REGULATOR_ACTIVITY": "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]", "GOMF_KINASE_ACTIVITY": "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732]", "GOMF_LAMININ_BINDING": "Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells. [GOC:ecd]", "GOMF_LAMIN_BINDING": "Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. [GOC:jl, ISBN:0198506732]", "GOMF_LBD_DOMAIN_BINDING": "Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. [PMID:9682036]", "GOMF_LARGE_RIBOSOMAL_SUBUNIT_RRNA_BINDING": "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. [GOC:elh]", "GOMF_LEUCINE_ZIPPER_DOMAIN_BINDING": "Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. [GOC:jl, InterPro:IPR002158]", "GOMF_LEUKOTRIENE_C4_SYNTHASE_ACTIVITY": "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). [EC:4.4.1.20, RHEA:17617]", "GOMF_LEUKOTRIENE_C4_GAMMA_GLUTAMYL_TRANSFERASE_ACTIVITY": "Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. [GOC:pz, PMID:1676842, PMID:9139674]", "GOMF_LIGAND_ACTIVATED_TRANSCRIPTION_FACTOR_ACTIVITY": "", "GOMF_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:dos]", "GOMF_LIGAND_GATED_MONOATOMIC_ANION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_LIGAND_GATED_SODIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]", "GOMF_LIGAND_GATED_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_LIGAND_GATED_MONOATOMIC_ION_CHANNEL_ACTIVITY_INVOLVED_IN_REGULATION_OF_PRESYNAPTIC_MEMBRANE_POTENTIAL": "Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. [GOC:dos, PMID:15145529, PMID:19558451]", "GOMF_LIGAND_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_LIGASE_ACTIVITY_FORMING_CARBON_CARBON_BONDS": "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.4.-.-]", "GOMF_LIGASE_ACTIVITY": "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. [EC:6.-.-.-]", "GOMF_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS": "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.3.-.-]", "GOMF_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS": "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.2.-.-]", "GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS": "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.1.-.-]", "GOMF_LIGASE_ACTIVITY_FORMING_PHOSPHORIC_ESTER_BONDS": "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.5.-.-]", "GOMF_LIPASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. [GOC:BHF, GOC:dph, GOC:tb]", "GOMF_LIM_DOMAIN_BINDING": "Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. [GOC:go_curators, Pfam:PF00412]", "GOMF_LIPASE_BINDING": "Binding to a lipase. [GOC:BHF]", "GOMF_LIPASE_ACTIVITY": "Catalysis of the hydrolysis of a lipid. [GOC:mah, ISBN:0198506732]", "GOMF_LIPASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. [GOC:BHF, GOC:rl]", "GOMF_LIPID_ANTIGEN_BINDING": "Binding to a lipid antigen. [PMID:14500461]", "GOMF_LIPID_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. [GOC:jl]", "GOMF_LIPID_TRANSFER_ACTIVITY": "Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]", "GOMF_LIPID_KINASE_ACTIVITY": "Catalysis of the phosphorylation of a simple or complex lipid. [GOC:hjd]", "GOMF_LIPOPEPTIDE_BINDING": "Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]", "GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a lipid from one side of a membrane to the other. [GOC:curators]", "GOMF_LIPID_TRANSPORTER_ACTIVITY": "Enables the directed movement of lipids into, out of or within a cell, or between cells. [GOC:ai]", "GOMF_LIPID_BINDING": "Binding to a lipid. [GOC:ai]", "GOMF_LIPOPOLYSACCHARIDE_IMMUNE_RECEPTOR_ACTIVITY": "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. [PMID:14609719, PMID:15379975]", "GOMF_LIPOPROTEIN_LIPASE_ACTIVITY": "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. May also hydrolyze diacylglycerol and phospholipids present in lipoproteins. [EC:3.1.1.34, GOC:bf]", "GOMF_LIPOPOLYSACCHARIDE_BINDING": "Binding to a lipopolysaccharide. [PMID:11079463]", "GOMF_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY": "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. [GOC:bf, GOC:mah, PMID:12827279]", "GOMF_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING": "Binding to a lipoprotein particle receptor. [GOC:BHF, GOC:rl]", "GOMF_LIPOTEICHOIC_ACID_BINDING": "Binding to lipoteichoic acid. [GOC:add, PMID:14665680]", "GOMF_LONG_CHAIN_FATTY_ACID_BINDING": "Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:pm, PMID:12641450]", "GOMF_LNCRNA_BINDING": "Binding to a long noncoding RNA (lncRNA). [PMID:25578728]", "GOMF_LONG_CHAIN_FATTY_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [ISBN:0198506732]", "GOMF_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY": "Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [RHEA:15421]", "GOMF_LONG_CHAIN_FATTY_ACYL_COA_HYDROLASE_ACTIVITY": "Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [RHEA:67680]", "GOMF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING": "Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. [GOC:mah]", "GOMF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY": "Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis. [GOC:bf, ISBN:0198506732]", "GOMF_LRR_DOMAIN_BINDING": "Binding to a LRR domain (leucine rich repeats) of a protein. [GOC:go_curators, Pfam:PF00560]", "GOMF_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING": "Binding to a low-density lipoprotein receptor. [GOC:ai]", "GOMF_LYSINE_N_ACETYLTRANSFERASE_ACTIVITY_ACTING_ON_ACETYL_PHOSPHATE_AS_DONOR": "", "GOMF_LYASE_ACTIVITY": "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [EC:4.-.-.-]", "GOMF_LYSINE_N_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. [GOC:mah]", "GOMF_LYSOPHOSPHATIDIC_ACID_BINDING": "Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors. [GOC:curators]", "GOMF_LYSOPHOSPHATIDIC_ACID_RECEPTOR_ACTIVITY": "Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, GOC:mah, PMID:15755723]", "GOMF_LYSOZYME_ACTIVITY": "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. [EC:3.2.1.17, PMID:22748813]", "GOMF_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. [GOC:cjk]", "GOMF_L_ALANINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]", "GOMF_LYSOPHOSPHOLIPASE_ACTIVITY": "Catalysis of the hydrolysis of a lysophospholipid (a phospholipid missing one fatty acid), removing the remaining acyl chain to yield a glycerophospho-compound and a free fatty acid. [GOC:curators]", "GOMF_LYSOPHOSPHATIDIC_ACID_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol. [PMID:20045079, PMID:7966317]", "GOMF_L_ARGININE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-arginine from one side of a membrane to the other. [GOC:dph]", "GOMF_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]", "GOMF_L_ASCORBIC_ACID_BINDING": "Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:mah]", "GOMF_L_ASPARTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]", "GOMF_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_L_GLUTAMINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_L_HISTIDINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_L_LEUCINE_BINDING": "Binding to L-leucine, 2-amino-4-methylpentanoic acid. [GOC:BHF, GOC:mah]", "GOMF_L_LEUCINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_L_LACTATE_DEHYDROGENASE_ACTIVITY": "", "GOMF_L_LYSINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_L_ORNITHINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_L_SERINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport]", "GOMF_L_PROLINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_MACROLIDE_BINDING": "Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. [GOC:jl, ISBN:0198506732]", "GOMF_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a macromolecule from one side of a membrane to the other. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. [GOC:dgf]", "GOMF_MALATE_DEHYDROGENASE_ACTIVITY": "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. [GOC:mah, ISBN:0582227089]", "GOMF_MANGANESE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. [GOC:dgf]", "GOMF_MANNOSE_BINDING": "", "GOMF_MAGNESIUM_ION_BINDING": "Binding to a magnesium (Mg) ion. [GOC:ai]", "GOMF_MANGANESE_ION_BINDING": "Binding to a manganese ion (Mn). [GOC:ai]", "GOMF_MANNOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai, GOC:cjm]", "GOMF_MANNOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. [GOC:ai]", "GOMF_MANNOSYL_OLIGOSACCHARIDE_1_2_ALPHA_MANNOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. [GOC:bf, PMID:25092655]", "GOMF_MANNOSYL_OLIGOSACCHARIDE_MANNOSIDASE_ACTIVITY": "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. [GOC:ai]", "GOMF_MAP_KINASE_ACTIVITY": "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. [GOC:ma, ISBN:0198547684]", "GOMF_MAP_KINASE_KINASE_ACTIVITY": "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a T-X-Y motif in the activation loop of a MAP kinase (MAPK) substrate. [PMID:12623839, PMID:38270553]", "GOMF_MAP_KINASE_KINASE_KINASE_KINASE_ACTIVITY": "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. [GOC:bf, PMID:11790549]", "GOMF_MAP_KINASE_KINASE_KINASE_ACTIVITY": "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. [PMID:9561267]", "GOMF_MAP_KINASE_SCAFFOLD_ACTIVITY": "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. [PMID:12511654, PMID:15213240, PMID:9405336]", "GOMF_MAP_KINASE_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. [GOC:mah, PMID:12184814]", "GOMF_MDM2_MDM4_FAMILY_PROTEIN_BINDING": "Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53. [InterPro:IPR016495]", "GOMF_MAP_KINASE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. [GOC:mah, PMID:12184814, PMID:17208316]", "GOMF_MECHANOSENSITIVE_MONOATOMIC_CATION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress. [GOC:ha, PMID:22343900]", "GOMF_MECHANOSENSITIVE_MONOATOMIC_ION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_MEDIUM_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY": "Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [RHEA:48340]", "GOMF_MELANOCORTIN_RECEPTOR_ACTIVITY": "Combining with melanocortin to initiate a change in cell activity. [GOC:ai]", "GOMF_MELANOCORTIN_RECEPTOR_BINDING": "Binding to a melanocortin receptor. [GOC:mah, GOC:nln]", "GOMF_MEMBRANE_INSERTASE_ACTIVITY": "Binds transmembrane domain-containing proteins and mediates their integration into a membrane. [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]", "GOMF_MEMBRANE_POTENTIAL_DRIVEN_UNIPORTER_ACTIVITY": "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_METALLOAMINOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]", "GOMF_METALLOCHAPERONE_ACTIVITY": "Binding to and delivering metal ions to a target protein. [PMID:11739376]", "GOMF_METALLOCARBOXYPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]", "GOMF_METALLODIPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]", "GOMF_METALLOENDOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]", "GOMF_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. [GOC:ai]", "GOMF_METALLOEXOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]", "GOMF_METAL_CATION_PROTON_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). [GOC:mlg]", "GOMF_METAL_CATION_MONOATOMIC_CATION_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out). [GOC:pg]", "GOMF_METALLOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]", "GOMF_METAL_CLUSTER_BINDING": "Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. [GOC:jsg]", "GOMF_METAL_DEPENDENT_DEUBIQUITINASE_ACTIVITY": "An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [PMID:19489724]", "GOMF_METAL_ION_SENSOR_ACTIVITY": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion. [GOC:pg]", "GOMF_METAL_ION_SEQUESTERING_ACTIVITY": "Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:12050156]", "GOMF_METHYLATION_DEPENDENT_PROTEIN_BINDING": "", "GOMF_MHC_CLASS_IB_PROTEIN_BINDING": "Binding to a major histocompatibility complex class Ib molecules. [GOC:mtg_signal, GOC:vw]", "GOMF_METHYL_CPG_BINDING": "Binding to a methylated cytosine/guanine dinucleotide. [GOC:jl, PMID:11746232]", "GOMF_MHC_CLASS_IB_RECEPTOR_ACTIVITY": "Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. [GOC:add, GOC:signaling, ISBN:0781735149]", "GOMF_MHC_CLASS_II_PROTEIN_BINDING": "Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]", "GOMF_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING": "Binding to a class II major histocompatibility complex. [GOC:mtg_signal, GOC:vw]", "GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of metal ions from one side of a membrane to the other. [GOC:ai]", "GOMF_MHC_CLASS_I_PROTEIN_BINDING": "Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]", "GOMF_MHC_CLASS_II_RECEPTOR_ACTIVITY": "Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]", "GOMF_MHC_CLASS_I_RECEPTOR_ACTIVITY": "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149]", "GOMF_MHC_CLASS_I_PROTEIN_COMPLEX_BINDING": "Binding to a class I major histocompatibility complex. [GOC:mtg_signal, GOC:vw]", "GOMF_MICROFIBRIL_BINDING": "Binding to a microfibril, any small fibril occurring in biological material. [GOC:ai]", "GOMF_MHC_PROTEIN_BINDING": "Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]", "GOMF_MHC_PROTEIN_COMPLEX_BINDING": "Binding to a major histocompatibility complex. [GOC:mtg_signal, GOC:vw]", "GOMF_MICROTUBULE_MINUS_END_BINDING": "Binding to the minus end of a microtubule. [GOC:ai, PMID:14557818, PMID:14614826]", "GOMF_MICROFILAMENT_MOTOR_ACTIVITY": "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. [PMID:29716949]", "GOMF_MICROTUBULE_PLUS_END_BINDING": "Binding to the plus end of a microtubule. [GOC:ai, PMID:14557818, PMID:14614826]", "GOMF_MICROTUBULE_SEVERING_ATPASE_ACTIVITY": "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. [PMID:10910766]", "GOMF_MICROTUBULE_BINDING": "Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc]", "GOMF_MINOR_GROOVE_OF_ADENINE_THYMINE_RICH_DNA_BINDING": "Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins. [GOC:jl, PMID:10545119, PMID:15802641, PMID:26223912, PMID:2670564]", "GOMF_MICROTUBULE_MOTOR_ACTIVITY": "A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. [PMID:19686686, PMID:32684327, PMID:32842864]", "GOMF_MINUS_END_DIRECTED_MICROTUBULE_MOTOR_ACTIVITY": "A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis. [GOC:mah, GOC:vw, PMID:15659646, PMID:32842864]", "GOMF_MIRNA_BINDING": "Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. [PMID:15066283]", "GOMF_MIRNA_INHIBITOR_ACTIVITY_VIA_BASE_PAIRING": "Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs). [PMID:34454184]", "GOMF_MISFOLDED_PROTEIN_BINDING": "Binding to a misfolded protein. [GOC:ai]", "GOMF_MISMATCHED_DNA_BINDING": "Binding to a double-stranded DNA region containing one or more mismatches. [GOC:mah]", "GOMF_MISMATCH_REPAIR_COMPLEX_BINDING": "Binding to a mismatch repair complex. [GOC:vk]", "GOMF_MITOCHONDRIAL_RIBOSOME_BINDING": "Binding to a mitochondrial ribosome. [GOC:ans, PMID:20739282]", "GOMF_MITOCHONDRION_TARGETING_SEQUENCE_BINDING": "Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion. [GOC:mah]", "GOMF_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING": "Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase. [GOC:mah]", "GOMF_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING": "Binding to a mitogen-activated protein kinase. [GOC:ai]", "GOMF_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING": "Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. [GOC:bf]", "GOMF_MITOGEN_ACTIVATED_PROTEIN_KINASE_P38_BINDING": "Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. [GOC:curators, PMID:17827184]", "GOMF_MODIFICATION_DEPENDENT_PROTEIN_BINDING": "Binding to a protein upon post-translation modification of the target protein. [PMID:26060076]", "GOMF_MODIFIED_AMINO_ACID_BINDING": "Binding to a modified amino acid. [GOC:mah]", "GOMF_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of modified amino acids from one side of a membrane to the other. [GOC:mah]", "GOMF_MOLECULAR_CARRIER_ACTIVITY": "Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. [GOC:molecular_function_refactoring, GOC:pdt]", "GOMF_MOLECULAR_CONDENSATE_SCAFFOLD_ACTIVITY": "Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. [PMID:28225081]", "GOMF_MOLECULAR_TAG_ACTIVITY": "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another molecule (for example a protein or a lipid) where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. [PMID:17632063]", "GOMF_MOLECULAR_ADAPTOR_ACTIVITY": "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]", "GOMF_MOLYBDOPTERIN_COFACTOR_BINDING": "Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. [ISSN:09498257]", "GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY": "A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators]", "GOMF_MOLECULAR_SEQUESTERING_ACTIVITY": "Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:13130076]", "GOMF_MONOAMINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. [GOC:mah]", "GOMF_MOLECULAR_FUNCTION_ACTIVATOR_ACTIVITY": "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators]", "GOMF_MONOATOMIC_ANION_MONOATOMIC_CATION_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). [TC:2.A.1.14.-]", "GOMF_MONOATOMIC_ANION_CHANNEL_ACTIVITY": "Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel. [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "GOMF_MONOATOMIC_ANION_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in). [TC:2.A.21.5.-]", "GOMF_MONOATOMIC_CATION_BICARBONATE_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in). [PMID:27166256]", "GOMF_MOLECULAR_TRANSDUCER_ACTIVITY": "A compound molecular function in which an effector function is controlled by one or more regulatory components. [GOC:dos, GOC:pdt]", "GOMF_MONOATOMIC_ION_GATED_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. [GOC:mtg_transport]", "GOMF_MONOATOMIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a negatively charged ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]", "GOMF_MONOCARBOXYLATE_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in). [GOC:ln, PMID:15322102]", "GOMF_MONOCARBOXYLIC_ACID_BINDING": "Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). [GOC:mah]", "GOMF_MONOATOMIC_CATION_CHANNEL_ACTIVITY": "Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel. [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. [GOC:ai]", "GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of cation from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]", "GOMF_MONOOXYGENASE_ACTIVITY": "Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. [PMID:1444267]", "GOMF_MONOSACCHARIDE_BINDING": "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. [GOC:jid]", "GOMF_MORPHOGEN_ACTIVITY": "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. [GOC:go_curators]", "GOMF_MRF_BINDING": "Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. [PMID:10966875]", "GOMF_MRNA_3_UTR_AU_RICH_REGION_BINDING": "Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]", "GOMF_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of an ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]", "GOMF_MRNA_5_UTR_BINDING": "Binding to an mRNA molecule at its 5' untranslated region. [GOC:jid]", "GOMF_MRNA_CDS_BINDING": "Binding to an mRNA molecule coding sequence (CDS). [GOC:kmv, PMID:25805859, SO:0000316]", "GOMF_MRNA_3_UTR_BINDING": "Binding to a 3' untranslated region of an mRNA molecule. [GOC:mah]", "GOMF_MUSCLE_ALPHA_ACTININ_BINDING": "Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. [PMID:10984498, PMID:11699871, PMID:15014165]", "GOMF_MRNA_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. [GOC:mah]", "GOMF_MRNA_REGULATORY_ELEMENT_BINDING_TRANSLATION_REPRESSOR_ACTIVITY": "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid. [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370]", "GOMF_MUTSALPHA_COMPLEX_BINDING": "Binding to a MutSalpha mismatch repair complex. [GOC:vk]", "GOMF_MUTLALPHA_COMPLEX_BINDING": "Binding to a MutLalpha mismatch repair complex. [GOC:vk]", "GOMF_MRNA_BINDING": "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234]", "GOMF_MYOSIN_HEAVY_CHAIN_BINDING": "Binding to a heavy chain of a myosin complex. [GOC:mah]", "GOMF_MYOSIN_II_BINDING": "Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. [GOC:mah, PMID:27697842]", "GOMF_MYOSIN_BINDING": "Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. [GOC:mah]", "GOMF_MYOSIN_LIGHT_CHAIN_BINDING": "Binding to a light chain of a myosin complex. [GOC:mah]", "GOMF_MYOSIN_PHOSPHATASE_ACTIVITY": "", "GOMF_MYOSIN_V_BINDING": "Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. [GOC:mah, PMID:11212351, PMID:33541831]", "GOMF_MYRISTOYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. [GOC:ai]", "GOMF_NAADP_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts. [PMID:19387438, PMID:19557428]", "GOMF_N6_METHYLADENOSINE_CONTAINING_RNA_READER_ACTIVITY": "A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. [PMID:22575960, PMID:24284625]", "GOMF_NADH_DEHYDROGENASE_ACTIVITY": "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. [RHEA:11356]", "GOMF_NADPH_BINDING": "Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]", "GOMF_NADH_DEHYDROGENASE_UBIQUINONE_ACTIVITY": "Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). [RHEA:29091]", "GOMF_NADPH_OXIDASE_H202_FORMING_ACTIVITY": "", "GOMF_NADPLUS_BINDING": "Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]", "GOMF_NADPLUS_NUCLEOSIDASE_ACTIVITY": "", "GOMF_NADPLUS_NUCLEOTIDASE_CYCLIC_ADP_RIBOSE_GENERATING": "", "GOMF_NADPLUS_PROTEIN_ADP_RIBOSYLTRANSFERASE_ACTIVITY": "", "GOMF_NADPLUS_PROTEIN_ASPARTATE_ADP_RIBOSYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:54424]", "GOMF_NADPLUS_PROTEIN_ARGININE_ADP_RIBOSYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. [RHEA:19149]", "GOMF_NADPLUS_PROTEIN_CYSTEINE_ADP_RIBOSYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]. [PMID:25043379, RHEA:56612]", "GOMF_NADPLUS_PROTEIN_LYSINE_ADP_RIBOSYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide. [PMID:25043379, RHEA:58220]", "GOMF_NADP_BINDING": "Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai]", "GOMF_NAD_BINDING": "Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai]", "GOMF_NAD_DEPENDENT_HISTONE_DEACETYLASE_ACTIVITY": "", "GOMF_NAD_DEPENDENT_PROTEIN_LYSINE_DEACETYLASE_ACTIVITY": "", "GOMF_NAD_P_H_DEHYDROGENASE_QUINONE_ACTIVITY": "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. [EC:1.6.5.2]", "GOMF_NAD_P_H_OXIDASE_H2O2_FORMING_ACTIVITY": "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. [EC:1.6.3.1, PMID:10401672, PMID:10601291, PMID:11822874]", "GOMF_NARROW_PORE_CHANNEL_ACTIVITY": "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_NATURAL_KILLER_CELL_LECTIN_LIKE_RECEPTOR_BINDING": "Binding to a lectin-like natural killer cell receptor. [GOC:ai]", "GOMF_NEDD8_TRANSFERASE_ACTIVITY": "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. [GOC:mah]", "GOMF_NAD_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of NAD from one side of a membrane to the other. [GOC:TermGenie]", "GOMF_NERVE_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to a nerve growth factor receptor. [GOC:ai, PMID:15654015]", "GOMF_NERVE_GROWTH_FACTOR_BINDING": "Binding to nerve growth factor (NGF). [GOC:dgh]", "GOMF_NETRIN_RECEPTOR_ACTIVITY": "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:dph, GOC:signaling, PMID:15960985]", "GOMF_NEUREGULIN_BINDING": "Binding to a neuregulin, a member of the EGF family of growth factors. [GOC:bf, GOC:signaling]", "GOMF_NEUROLIGIN_FAMILY_PROTEIN_BINDING": "Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692]", "GOMF_NEUREXIN_FAMILY_PROTEIN_BINDING": "Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. [GOC:curators, GOC:pr, PMID:18923512]", "GOMF_NEUROPEPTIDE_BINDING": "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [PMID:10414961, PMID:38337033]", "GOMF_NEUROPEPTIDE_ACTIVITY": "The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron. [PMID:18806786, PMID:21922398]", "GOMF_NEUROPEPTIDE_Y_RECEPTOR_ACTIVITY": "Combining with neuropeptide Y to initiate a change in cell activity. [PMID:9315606]", "GOMF_NEUROPEPTIDE_RECEPTOR_BINDING": "Binding to a neuropeptide receptor. [GOC:kmv, GOC:mah]", "GOMF_NEUROPEPTIDE_RECEPTOR_ACTIVITY": "Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai]", "GOMF_NEUROTRANSMITTER_RECEPTOR_REGULATOR_ACTIVITY": "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing. [GOC:dos, PMID:12740117, PMID:18387948]", "GOMF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY": "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "GOMF_NEUROTRANSMITTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai, ISBN:0198506732]", "GOMF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY_INVOLVED_IN_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL": "Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel). [GOC:dos]", "GOMF_NEUROTROPHIN_BINDING": "Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. [GOC:jl]", "GOMF_NEUROTROPHIN_RECEPTOR_ACTIVITY": "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]", "GOMF_NEUROTROPHIN_RECEPTOR_BINDING": "Binding to a neurotrophin receptor. [GOC:ai]", "GOMF_NEUROTROPHIN_TRK_RECEPTOR_BINDING": "Binding to a neurotrophin TRK receptor. [GOC:ai]", "GOMF_NEUTRAL_L_AMINO_ACID_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in). [TC:2.A.23.3.1]", "GOMF_NFAT_PROTEIN_BINDING": "Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. [PMID:15928679]", "GOMF_NITRIC_OXIDE_SYNTHASE_BINDING": "Binding to nitric-oxide synthase. [GOC:ai]", "GOMF_NF_KAPPAB_BINDING": "Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. [GOC:ai]", "GOMF_NEUTRAL_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_NITRITE_REDUCTASE_ACTIVITY": "Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor. [GOC:dos, GOC:jh]", "GOMF_NITRIC_OXIDE_SYNTHASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of nitric oxide synthase. [GOC:mah]", "GOMF_NMDA_GLUTAMATE_RECEPTOR_ACTIVITY": "A cation channel that opens in response to binding by extracellular glutmate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages. [GOC:mah, PMID:10049997, PMID:7790891]", "GOMF_NODAL_BINDING": "Binding to a nodal protein, a member of the transforming growth factor-beta superfamily. [GOC:bf, PMID:20629020]", "GOMF_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [PMID:34353440]", "GOMF_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. [EC:2.7.10.2]", "GOMF_NOTCH_BINDING": "Binding to a Notch (N) protein, a surface receptor. [GOC:ceb]", "GOMF_NUCLEAR_ANDROGEN_RECEPTOR_BINDING": "Binding to a nuclear androgen receptor. [GOC:ai]", "GOMF_NUCLEAR_EXPORT_SIGNAL_RECEPTOR_ACTIVITY": "Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein. [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]", "GOMF_NUCLEAR_IMPORT_SIGNAL_RECEPTOR_ACTIVITY": "Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]", "GOMF_NUCLEAR_GLUCOCORTICOID_RECEPTOR_BINDING": "Binding to a nuclear glucocorticoid receptor. [GOC:bf]", "GOMF_NUCLEAR_ESTROGEN_RECEPTOR_BINDING": "Binding to a nuclear estrogen receptor. [GOC:ai]", "GOMF_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING": "Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. [GOC:ai]", "GOMF_NUCLEAR_RECEPTOR_COACTIVATOR_ACTIVITY": "", "GOMF_NUCLEAR_RETINOIC_ACID_RECEPTOR_BINDING": "Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. [GOC:jl, PMID:12476796]", "GOMF_NUCLEAR_RECEPTOR_BINDING": "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. [PMID:7776974]", "GOMF_NUCLEAR_RETINOID_X_RECEPTOR_BINDING": "Binding to a nuclear retinoid X receptor. [GOC:ai]", "GOMF_NUCLEAR_STEROID_RECEPTOR_ACTIVITY": "A nuclear receptor activity regulated by steroid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:signaling, PMID:14708019]", "GOMF_NUCLEAR_VITAMIN_D_RECEPTOR_BINDING": "Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. [GOC:jl, PMID:12637589]", "GOMF_NUCLEAR_THYROID_HORMONE_RECEPTOR_BINDING": "Binding to a nuclear thyroid hormone receptor. [GOC:ai]", "GOMF_NUCLEASE_INHIBITOR_ACTIVITY": "Binds to and modulates the activity of a nuclease. [PMID:28785032, PMID:29554913, PMID:30046034]", "GOMF_NUCLEASE_ACTIVITY": "Catalysis of the cleavage of ester linkages within nucleic acids. [ISBN:0198547684]", "GOMF_NUCLEOBASE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. [ISBN:0198506732]", "GOMF_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY": "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. [GOC:jl]", "GOMF_NUCLEOCYTOPLASMIC_CARRIER_ACTIVITY": "Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein. [GOC:pg]", "GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. [GOC:ai]", "GOMF_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. [EC:2.7.4.6]", "GOMF_NUCLEOSIDE_BINDING": "Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. [GOC:hjd]", "GOMF_NUCLEOSIDE_DIPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. [EC:3.6.1.6]", "GOMF_NUCLEOSIDE_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. [GOC:ai]", "GOMF_NUCLEOSIDE_MONOPHOSPHATE_KINASE_ACTIVITY": "Catalysis of the reaction: a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP. [RHEA:24036]", "GOMF_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. [GOC:ai]", "GOMF_NUCLEOSIDE_TRIPHOSPHATE_DIPHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. [EC:3.6.1.9]", "GOMF_NUCLEOSOMAL_DNA_BINDING": "Binding to the DNA portion of a nucleosome. [GOC:mah]", "GOMF_NUCLEOSOME_BINDING": "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:mah]", "GOMF_NUCLEOTIDE_RECEPTOR_ACTIVITY": "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. [GOC:signaling, ISBN:0198506732]", "GOMF_NUCLEOTIDASE_ACTIVITY": "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. [RHEA:22140]", "GOMF_NUCLEOTIDE_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]", "GOMF_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of an NTPase. [GOC:dph, GOC:tb]", "GOMF_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. [ISBN:0198506732]", "GOMF_N_ACETYLGALACTOSAMINE_4_O_SULFOTRANSFERASE_ACTIVITY": "", "GOMF_N_ACETYLGLUCOSAMINE_6_O_SULFOTRANSFERASE_ACTIVITY": "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. [GOC:ai, GOC:hjd]", "GOMF_NUCLEOTIDYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). [EC:2.7.7.-]", "GOMF_N_ACETYLLACTOSAMINE_SYNTHASE_ACTIVITY": "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. [EC:2.4.1.90]", "GOMF_N_ACETYLLACTOSAMINIDE_BETA_1_3_N_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H+ + UDP. [RHEA:14389]", "GOMF_N_ACYLSPHINGOSINE_AMIDOHYDROLASE_ACTIVITY": "Catalysis of the reaction: an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine. [RHEA:20856]", "GOMF_N_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. [GOC:ai]", "GOMF_N_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. [GOC:ai]", "GOMF_N_FORMYL_PEPTIDE_RECEPTOR_ACTIVITY": "Combining with an N-formyl peptide to initiate a change in cell activity. [GOC:ai]", "GOMF_N_N_DIMETHYLANILINE_MONOOXYGENASE_ACTIVITY": "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. [RHEA:24468]", "GOMF_N_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. [GOC:ai]", "GOMF_OLEATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_ODORANT_BINDING": "Binding to an odorant, any substance capable of stimulating the sense of smell. [GOC:jl, ISBN:0721662544]", "GOMF_OLIGOPEPTIDE_BINDING": "Binding to an oligopeptide. [GOC:TermGenie, PMID:21854595]", "GOMF_OLFACTORY_RECEPTOR_BINDING": "Binding to an olfactory receptor. [GOC:mah, GOC:nln]", "GOMF_OLIGOPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [GOC:vw, ISBN:0198506732]", "GOMF_OLIGOSACCHARIDE_BINDING": "Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [GOC:mah]", "GOMF_OLIGOSACCHARYL_TRANSFERASE_ACTIVITY": "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]", "GOMF_OMEGA_PEPTIDASE_ACTIVITY": "Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes. [EC:3.4.19.-, PMID:20157488, PMID:9920379]", "GOMF_OLFACTORY_RECEPTOR_ACTIVITY": "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]", "GOMF_OPIOID_RECEPTOR_BINDING": "Binding to an opioid receptor. [GOC:nln]", "GOMF_OPSIN_BINDING": "Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. [GOC:hjd]", "GOMF_OPSONIN_BINDING": "Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. [GOC:add, ISBN:0781735149]", "GOMF_OPSONIN_RECEPTOR_ACTIVITY": "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]", "GOMF_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). [TC:2.A.28.1.1]", "GOMF_ORGANIC_ACID_BINDING": "Binding to an organic acid, any acidic compound containing carbon in covalent linkage. [GOC:jl, ISBN:0198506732]", "GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_ORGANOPHOSPHATE_PHOSPHATE_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + phosphate(in) = organophosphate(in) +  phosphate(out). [TC:2.A.1.4.-]", "GOMF_ORNITHINE_DECARBOXYLASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of the enzyme ornithine decarboxylase. [GOC:jl]", "GOMF_OSMOSENSOR_ACTIVITY": "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. [GOC:dph, GOC:tb]", "GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. [GOC:mcc]", "GOMF_OUTWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. [GOC:mah]", "GOMF_OXIDATIVE_PHOSPHORYLATION_UNCOUPLER_ACTIVITY": "Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. [PMID:15738989, PMID:16179945]", "GOMF_OXIDATIVE_RNA_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. [PMID:12594517, PMID:16482161, PMID:18775698]", "GOMF_OXALATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. [ISBN:0198506732]", "GOMF_OXIDIZED_DNA_BINDING": "Binding to a DNA region containing an oxidized residue. [GOC:vk]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS": "", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_NAD_P_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. [GOC:jl]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [EC:1.8.-.-, GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OR_CH2_GROUPS_DISULFIDE_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OR_CH2_GROUPS": "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY": "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [EC:1.-.-.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_DIPHENOLS_AND_RELATED_SUBSTANCES_AS_DONORS": "", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_METAL_IONS": "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. [GOC:mah]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR": "Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor. [GOC:mah]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_HEME_PROTEIN_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_METAL_IONS_OXYGEN_AS_ACCEPTOR": "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor. [GOC:mah]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_OTHER_NITROGENOUS_COMPOUNDS_AS_DONORS": "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [EC:1.7.-.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. [EC:1.6.3.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_OTHER_NITROGENOUS_COMPOUNDS_AS_DONORS_CYTOCHROME_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome. [EC:1.7.2.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_ANOTHER_COMPOUND_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. [EC:1.14.18.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. [EC:1.14.13.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_ASCORBATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. [EC:1.14.17.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. [EC:1.14.-.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_IRON_SULFUR_PROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. [EC:1.14.15.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. [EC:1.14.14.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_PTERIDINE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. [EC:1.14.16.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_OXIDATION_OF_A_PAIR_OF_DONORS_RESULTING_IN_THE_REDUCTION_OF_MOLECULAR_OXYGEN_TO_TWO_MOLECULES_OF_WATER": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. [EC:1.14.19.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN": "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. [EC:1.13.-.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. [EC:1.11.-.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. [GOC:jl]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. [EC:1.3.3.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_WITH_A_FLAVIN_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin. [EC:1.3.8.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [EC:1.3.-.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [EC:1.4.-.-, GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. [GOC:ai]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. [EC:1.3.1.-]", "GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]", "GOMF_OXYGEN_CARRIER_ACTIVITY": "Binding to oxygen and delivering it to an acceptor molecule or a specific location. [GOC:ai]", "GOMF_OXYSTEROL_BINDING": "Binding to oxysterol, an oxidized form of cholesterol. [GOC:curators]", "GOMF_OXYGEN_SENSOR_ACTIVITY": "Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). [GOC:mah]", "GOMF_OXO_ACID_LYASE_ACTIVITY": "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. [EC:4.1.3.-, GOC:jl]", "GOMF_OXIDOREDUCTION_DRIVEN_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]", "GOMF_OXYGEN_BINDING": "Binding to oxygen (O2). [GOC:jl]", "GOMF_O_ACETYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. [GOC:ai]", "GOMF_O_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. [GOC:ai]", "GOMF_O_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. [GOC:ai]", "GOMF_O_PALMITOYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule. [GOC:ai]", "GOMF_PALMITOYL_HYDROLASE_ACTIVITY": "Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate. [GOC:dos, GOC:pg]", "GOMF_P53_BINDING": "Binding to one of the p53 family of proteins. [GOC:hjd]", "GOMF_PALMITOYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. [GOC:ai]", "GOMF_PATCHED_BINDING": "Binding to a patched (ptc) protein, a receptor for hedgehog proteins. [GOC:ceb, PMID:11731473]", "GOMF_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS": "Binds to and increases the activity of a peptidase that is involved in the apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]", "GOMF_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY": "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response. [GOC:ar, GOC:bf]", "GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_PENTOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). [GOC:jl]", "GOMF_PDZ_DOMAIN_BINDING": "Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]", "GOMF_PEPTIDASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a peptidase. [GOC:ai]", "GOMF_PEPTIDE_ALPHA_N_ACETYLTRANSFERASE_ACTIVITY": "", "GOMF_PEPTIDASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. [GOC:dph, GOC:tb]", "GOMF_PEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [EC:3.4.-.-, GOC:jl]", "GOMF_PEPTIDE_ANTIGEN_BINDING": "Binding to an antigen peptide. [GOC:add, GOC:jl, GOC:rv]", "GOMF_PEPTIDE_HORMONE_BINDING": "Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]", "GOMF_PEPTIDE_LYSINE_N_ACETYLTRANSFERASE_ACTIVITY": "", "GOMF_PEPTIDE_HORMONE_RECEPTOR_BINDING": "Binding to a receptor for a peptide hormone. [GOC:ai]", "GOMF_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY": "", "GOMF_PEPTIDE_BINDING": "Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl]", "GOMF_PEPTIDE_RECEPTOR_ACTIVITY": "Combining with an extracellular or intracellular peptide to initiate a change in cell activity. [GOC:jl]", "GOMF_PEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a peptide from one side of a membrane to the other. [GO_REF:0000070, GOC:TermGenie, GOC:vw]", "GOMF_PEPTIDOGLYCAN_BINDING": "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. [GOC:go_curators, PMID:14698226]", "GOMF_PEPTIDOGLYCAN_IMMUNE_RECEPTOR_ACTIVITY": "Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response. [PMID:14698226]", "GOMF_PEPTIDOGLYCAN_MURALYTIC_ACTIVITY": "A catalytic activity that contributes to the degradation of peptidoglycan. [GOC:dph, GOC:jh, PMID:22748813]", "GOMF_PEPTIDYL_PROLINE_4_DIOXYGENASE_ACTIVITY": "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2. [GOC:mah]", "GOMF_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY": "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]", "GOMF_PEROXIREDOXIN_ACTIVITY": "Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. [RHEA:10008]", "GOMF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING": "Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma. [GOC:jl, PMID:12769781]", "GOMF_PEROXISOME_TARGETING_SEQUENCE_BINDING": "Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome. [GOC:mah, ISBN:0879693568]", "GOMF_PHEROMONE_RECEPTOR_ACTIVITY": "", "GOMF_PHOSPHATASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a phosphatase. [GOC:ai]", "GOMF_PHOSPHATASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a phosphatase. [GOC:ai]", "GOMF_PHOSPHATASE_ACTIVITY": "Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. [GOC:curators, GOC:pg]", "GOMF_PHOSPHATE_ION_BINDING": "Binding to a phosphate ion. [GOC:jl]", "GOMF_PHOSPHATASE_BINDING": "Binding to a phosphatase. [GOC:jl]", "GOMF_PHOSPHATASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. [GOC:ai]", "GOMF_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. [GOC:pr, PMID:25814022, RHEA:27429]", "GOMF_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]", "GOMF_PHOSPHATIDIC_ACID_BINDING": "Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [CHEBI:16337, GOC:jp, ISBN:0198506732]", "GOMF_PHOSPHATIDYLCHOLINE_BINDING": "Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:mah, ISBN:0198506732]", "GOMF_PHOSPHATIDIC_ACID_TRANSFER_ACTIVITY": "Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3. [PMID:23042293]", "GOMF_PHOSPHATIDYLCHOLINE_FLIPPASE_ACTIVITY": "Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. [PMID:11870854]", "GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY": "Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, RHEA:38583]", "GOMF_PHOSPHATIDYLCHOLINE_STEROL_O_ACYLTRANSFERASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase. [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615]", "GOMF_PHOSPHATIDYLCHOLINE_TRANSFER_ACTIVITY": "Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]", "GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY": "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:ai, ISBN:0198506732]", "GOMF_PHOSPHATIDYLETHANOLAMINE_FLIPPASE_ACTIVITY": "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, PMID:20043909]", "GOMF_PHOSPHATIDYLETHANOLAMINE_BINDING": "Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732]", "GOMF_PHOSPHATIDYLGLYCEROL_BINDING": "Binding to phosphatidylglycerol. [GOC:kmv, GOC:TermGenie]", "GOMF_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_3_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. [EC:3.1.3.67]", "GOMF_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_5_PHOSPHATASE_ACTIVITY": "1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate. [EC:3.1.3.86, GOC:pf]", "GOMF_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING": "Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. [GOC:bf, GOC:jl]", "GOMF_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. [PMID:19901554, RHEA:39019]", "GOMF_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING": "Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. [GOC:bf, GOC:go_curators]", "GOMF_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING": "Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. [GOC:bf, PMID:18397324]", "GOMF_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_5_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate. [PMID:10806194, PMID:16607019, RHEA:32955]", "GOMF_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. [GOC:hjd]", "GOMF_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING": "Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. [PMID:10209156, PMID:9255069]", "GOMF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K). [PMID:31686003]", "GOMF_PHOSPHATIDYLINOSITOL_3_KINASE_INHIBITOR_ACTIVITY": "Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K). [PMID:31686003]", "GOMF_PHOSPHATIDYLINOSITOL_3_KINASE_REGULATORY_SUBUNIT_BINDING": "Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. [GOC:bf, PMID:20505341]", "GOMF_PHOSPHATIDYLINOSITOL_3_KINASE_REGULATOR_ACTIVITY": "Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. [GOC:bf, PMID:9255069]", "GOMF_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. [GOC:hjd]", "GOMF_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_5_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. [RHEA:22764]", "GOMF_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING": "Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]", "GOMF_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING": "Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. [GOC:bf, GOC:jl]", "GOMF_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING": "Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. [GOC:bf, GOC:tair_curators]", "GOMF_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING": "Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. [GOC:bf, GOC:mah]", "GOMF_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate. [GOC:ai]", "GOMF_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. [GOC:ai]", "GOMF_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING": "Binding to phosphatidylinositol bisphosphate. [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]", "GOMF_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY": "Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. [GOC:elh]", "GOMF_PHOSPHATIDYLINOSITOL_PHOSPHATE_4_PHOSPHATASE_ACTIVITY": "Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. [GOC:mah]", "GOMF_PHOSPHATIDYLINOSITOL_BINDING": "Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417]", "GOMF_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. [GOC:ai]", "GOMF_PHOSPHATIDYLINOSITOL_TRANSFER_ACTIVITY": "Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]", "GOMF_PHOSPHATIDYLINOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate. [GOC:mah]", "GOMF_PHOSPHATIDYLSERINE_1_ACYLHYDROLASE_ACTIVITY": "", "GOMF_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING": "Binding to phosphatidylinositol phosphate. [GOC:TermGenie, PMID:23445487]", "GOMF_PHOSPHATIDYLSERINE_FLIPPASE_ACTIVITY": "Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. [PMID:11870854]", "GOMF_PHOSPHATIDYLSERINE_BINDING": "Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. [ISBN:0198506732, PMID:12000961]", "GOMF_PHOSPHODIESTERASE_I_ACTIVITY": "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. [EC:3.1.4.1]", "GOMF_PHOSPHATIDYLSERINE_FLOPPASE_ACTIVITY": "Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, PMID:20224745, RHEA:38567]", "GOMF_PHOSPHATIDYL_PHOSPHOLIPASE_B_ACTIVITY": "", "GOMF_PHOSPHOFRUCTOKINASE_ACTIVITY": "Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. [GOC:jl]", "GOMF_PHOSPHOLIPASE_A1_ACTIVITY": "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+. [RHEA:18689]", "GOMF_PHOSPHOLIPASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. [GOC:ai]", "GOMF_PHOSPHOLIPASE_A2_ACTIVITY": "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801]", "GOMF_PHOSPHOLIPASE_ACTIVITY": "Catalysis of the hydrolysis of a glycerophospholipid. [ISBN:0198506732]", "GOMF_PHOSPHOLIPASE_D_ACTIVITY": "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. [EC:3.1.4.4]", "GOMF_PHOSPHOLIPASE_BINDING": "Binding to a phospholipase. [GOC:jl]", "GOMF_PHOSPHOLIPASE_C_ACTIVITY": "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. [GOC:mah]", "GOMF_PHOSPHOLIPASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. [GOC:ai, GOC:rl]", "GOMF_PHOSPHOLIPID_TRANSFER_ACTIVITY": "Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]", "GOMF_PHOSPHOLIPID_SCRAMBLASE_ACTIVITY": "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. [GOC:cjm, PMID:20043909, PMID:20302864]", "GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY": "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. [GOC:ai, ISBN:0198506732]", "GOMF_PHOSPHOLIPID_BINDING": "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732]", "GOMF_PHOSPHOPROTEIN_BINDING": "Binding to a phosphorylated protein. [GOC:ai]", "GOMF_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY": "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. [EC:3.1.4.-]", "GOMF_PHOSPHORUS_OXYGEN_LYASE_ACTIVITY": "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]", "GOMF_PHOSPHORYLATION_DEPENDENT_PROTEIN_BINDING": "Binding to a protein upon phosphorylation of the target protein. [PMID:26060076]", "GOMF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. [ISBN:0198547684]", "GOMF_PHOSPHOSERINE_RESIDUE_BINDING": "Binding to a phosphorylated serine residue within a protein. [GOC:ai]", "GOMF_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS": "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). [EC:2.7.8.-]", "GOMF_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR": "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). [EC:2.7.3.-]", "GOMF_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY": "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. [GOC:jl]", "GOMF_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR": "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). [EC:2.7.4.-]", "GOMF_PHOSPHOTYROSINE_RESIDUE_BINDING": "Binding to a phosphorylated tyrosine residue within a protein. [PMID:14636584]", "GOMF_PHOTORECEPTOR_ACTIVITY": "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. [GOC:ai, GOC:go_curators]", "GOMF_PIRNA_BINDING": "Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. [GOC:kmv]", "GOMF_PH_DOMAIN_BINDING": "Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. [GOC:jl, Pfam:PF00169]", "GOMF_PLATELET_DERIVED_GROWTH_FACTOR_BINDING": "Binding to platelet-derived growth factor. [GOC:dgh]", "GOMF_PLUS_END_DIRECTED_MICROTUBULE_MOTOR_ACTIVITY": "A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. [GOC:vw, PMID:32842864]", "GOMF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to a platelet-derived growth factor receptor. [GOC:ai]", "GOMF_POLYAMINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other. [GOC:ai]", "GOMF_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol. [ISBN:0198506732]", "GOMF_POLYSACCHARIDE_BINDING": "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:mah]", "GOMF_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. [EC:2.4.1.41, ISBN:0879695595]", "GOMF_POLY_ADP_D_RIBOSE_BINDING": "Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. [GOC:mah, GOC:sart, PMID:20088964]", "GOMF_POLY_ADP_D_RIBOSE_MODIFICATION_DEPENDENT_PROTEIN_BINDING": "Binding to a protein upon poly-ADP-ribosylation of the target protein. [PMID:26673700]", "GOMF_POLYUBIQUITIN_MODIFICATION_DEPENDENT_PROTEIN_BINDING": "Binding to a protein upon poly-ubiquitination of the target protein. [GOC:pg]", "GOMF_POLY_A_BINDING": "Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. [GOC:jl]", "GOMF_POLY_A_RNA_POLYMERASE_ACTIVITY": "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. [PMID:13965521, RHEA:11332]", "GOMF_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY": "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. [EC:3.1.13.4, ISBN:0198547684]", "GOMF_POLY_G_BINDING": "Binding to a sequence of guanine residues in an RNA molecule. [GOC:mah]", "GOMF_POLY_PYRIMIDINE_TRACT_BINDING": "Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule. [GOC:jl]", "GOMF_POLY_PURINE_TRACT_BINDING": "Binding to a stretch of purines (adenine or guanine) in an RNA molecule. [GOC:mah]", "GOMF_PORIN_ACTIVITY": "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-]", "GOMF_POTASSIUM_CHANNEL_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a potassium channel, resulting in its opening. [GOC:dos]", "GOMF_POSTSYNAPTIC_NEUROTRANSMITTER_RECEPTOR_ACTIVITY": "Neurotransmitter receptor activity occurring in the postsynaptic membrane during synaptic transmission. [GOC:dos, GOC:signaling]", "GOMF_POTASSIUM_CHANNEL_INHIBITOR_ACTIVITY": "Binds to and stops, prevents, or reduces the activity of a potassium channel. [GOC:mah]", "GOMF_POTASSIUM_CHLORIDE_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). [TC:2.A.30.1.5]", "GOMF_POTASSIUM_CHANNEL_ACTIVITY": "Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "GOMF_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a potassium channel. [GOC:dos, GOC:mah]", "GOMF_POTASSIUM_ION_BINDING": "Binding to a potassium ion (K+). [GOC:mah]", "GOMF_POTASSIUM_ION_LEAK_CHANNEL_ACTIVITY": "Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_POTASSIUM_PROTON_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). [TC:2.A.37.-.-]", "GOMF_POU_DOMAIN_BINDING": "Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors. [GOC:mah, GOC:yaf, InterPro:IPR000327]", "GOMF_PRENYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). [GOC:mah]", "GOMF_PRERIBOSOME_BINDING": "Binding to a preribosome. [GOC:di, PMID:22735702]", "GOMF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of potassium ions (K+) from one side of a membrane to the other. [GOC:ai]", "GOMF_PRE_MIRNA_BINDING": "Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. [PMID:18951094]", "GOMF_PRE_MRNA_3_SPLICE_SITE_BINDING": "Binding to a pre-mRNA 3' splice site sequence. [GOC:jl]", "GOMF_PRE_MRNA_5_SPLICE_SITE_BINDING": "Binding to a pre-mRNA 5' splice site sequence. [GOC:jl]", "GOMF_PRE_MRNA_INTRONIC_BINDING": "Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA). [GOC:ans, PMID:16260624]", "GOMF_PRE_MRNA_BINDING": "Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]", "GOMF_PRIMARY_AMINE_OXIDASE_ACTIVITY": "", "GOMF_PRIMARY_MIRNA_BINDING": "Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. [GOC:sl, PMID:15531877, PMID:15574589]", "GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy. [GOC:mtg_transport, PMID:31613498]", "GOMF_PROCOLLAGEN_PROLINE_4_DIOXYGENASE_ACTIVITY": "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. [EC:1.14.11.2]", "GOMF_PROCOLLAGEN_PROLINE_DIOXYGENASE_ACTIVITY": "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2. [GOC:mah, PMID:4371784]", "GOMF_PROFILIN_BINDING": "Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. [ISBN:0721662544]", "GOMF_PROLINE_RICH_REGION_BINDING": "Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. [GOC:mah]", "GOMF_PROLINE_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). [TC:2.A.22.2.1]", "GOMF_PROMOTER_ENHANCER_LOOP_ANCHORING_ACTIVITY": "Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop. [PMID:32213323]", "GOMF_PROSTANOID_RECEPTOR_ACTIVITY": "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity. [ISBN:0198506732]", "GOMF_PROMOTER_SPECIFIC_CHROMATIN_BINDING": "Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]", "GOMF_PROSTAGLANDIN_E_RECEPTOR_ACTIVITY": "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. [ISBN:0198506732]", "GOMF_PROTEASOME_ACTIVATING_ACTIVITY": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. [GOC:rb, PMID:11430818]", "GOMF_PROTEINASE_ACTIVATED_RECEPTOR_ACTIVITY": "A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. [GOC:mah, PMID:11356985, PMID:33742547]", "GOMF_PROTEASOME_BINDING": "Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation. [GOC:mah]", "GOMF_PROTEASE_BINDING": "Binding to a protease or a peptidase. [GOC:hjd]", "GOMF_PROTEIN_ARGININE_DEIMINASE_ACTIVITY": "Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent. [PMID:27393304]", "GOMF_PROTEIN_ANTIGEN_BINDING": "Binding to a protein antigen. [PMID:9360996]", "GOMF_PROTEIN_ARGININE_N_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. [GOC:mah, PMID:12351636, PMID:31284549]", "GOMF_PROTEIN_BINDING_INVOLVED_IN_HETEROTYPIC_CELL_CELL_ADHESION": "Binding to a protein or protein complex contributing to the adhesion of two different types of cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOMF_PROTEIN_ARGININE_OMEGA_N_MONOMETHYLTRANSFERASE_ACTIVITY": "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine. [EC:2.1.1.321, PMID:14705965, RESID:AA0069]", "GOMF_PROTEIN_ARGININE_OMEGA_N_ASYMMETRIC_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. [PMID:14705965]", "GOMF_PROTEIN_CARBOXYL_O_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group to a carboxyl group on a protein. [GOC:ai]", "GOMF_PROTEIN_CONTAINING_COMPLEX_DESTABILIZING_ACTIVITY": "A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex. [PMID:23727094, PMID:29779865, PMID:34836783]", "GOMF_PROTEIN_CARRIER_CHAPERONE": "Binding to and carrying a protein between two different cellular components by moving along with the target protein. [PMID:7628437]", "GOMF_PROTEIN_CYSTEINE_S_STEAROYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]. [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59740]", "GOMF_PROTEIN_DEMETHYLASE_ACTIVITY": "Catalysis of the removal of a methyl group from a protein. [PMID:24498420, PMID:28360925]", "GOMF_PROTEIN_DISULFIDE_REDUCTASE_NAD_P_H_ACTIVITY": "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. [EC:1.8.1.8]", "GOMF_PROTEIN_DISULFIDE_ISOMERASE_ACTIVITY": "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]", "GOMF_PROTEIN_GERANYLGERANYLTRANSFERASE_ACTIVITY": "", "GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING": "Binding to a macromolecular complex. [GOC:jl]", "GOMF_PROTEIN_FOLDING_CHAPERONE": "Binding to a protein or a protein-containing complex to assist the protein folding process. [GOC:mtg_cambridge_2009]", "GOMF_PROTEIN_GLUTAMIC_ACID_LIGASE_ACTIVITY": "Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein. [GOC:mah, PMID:19524510]", "GOMF_PROTEIN_FOLDING_CHAPERONE_BINDING": "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]", "GOMF_PROTEIN_GLUTAMINE_GAMMA_GLUTAMYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. [EC:2.3.2.13]", "GOMF_PROTEIN_DIMERIZATION_ACTIVITY": "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. [ISBN:0198506732]", "GOMF_PROTEIN_DOMAIN_SPECIFIC_BINDING": "Binding to a specific domain of a protein. [GOC:go_curators]", "GOMF_PROTEIN_HORMONE_RECEPTOR_ACTIVITY": "Combining with a protein hormone to initiate a change in cell activity. [GOC:mah]", "GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY": "Binding to a nonidentical protein to form a heterodimer. [GOC:ai]", "GOMF_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING": "Binding to one or both of the regulatory subunits of protein kinase A. [GOC:mah]", "GOMF_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING": "Binding to one or both of the catalytic subunits of protein kinase A. [GOC:mah]", "GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY": "Binding to an identical protein to form a homodimer. [GOC:jl]", "GOMF_PROTEIN_KINASE_A_BINDING": "Binding to a protein kinase A. [GOC:ai]", "GOMF_PROTEIN_KINASE_B_BINDING": "Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. [GOC:jl, https://doi.org/10.1016/S0092-8674(02)01083-8]", "GOMF_PROTEIN_KINASE_C_BINDING": "Binding to protein kinase C. [GOC:jl]", "GOMF_PROTEIN_LIPID_COMPLEX_BINDING": "Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. [GOC:BHF, GOC:mah]", "GOMF_PROTEIN_KINASE_ACTIVITY": "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]", "GOMF_PROTEIN_LYSINE_DEACETYLASE_ACTIVITY": "Catalysis of the reaction: Removal of an acetyl group from a lysine residue in a protein. [PMID:27296530, RHEA:58108]", "GOMF_PROTEIN_LYSINE_6_OXIDASE_ACTIVITY": "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. [EC:1.4.3.13]", "GOMF_PROTEIN_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group (CH3-) to a protein. [GOC:jl]", "GOMF_PROTEIN_MEMBRANE_ADAPTOR_ACTIVITY": "The binding activity of a molecule that brings together a protein or a protein complex with a membrane, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. [GOC:go_curators]", "GOMF_PROTEIN_PHOSPHATASE_1_BINDING": "Binding to a protein phosphatase 1. [GOC:jl]", "GOMF_PROTEIN_PHOSPHATASE_2A_BINDING": "Binding to protein phosphatase 2A. [GOC:ai]", "GOMF_PROTEIN_PHOSPHATASE_2B_BINDING": "Binding to a protein phosphatase 2B. [GOC:jl]", "GOMF_PROTEIN_PRENYLTRANSFERASE_ACTIVITY": "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. [GOC:mah]", "GOMF_PROTEIN_RNA_ADAPTOR_ACTIVITY": "The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way. [PMID:24470144]", "GOMF_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING": "Binding to a phosphorylated amino acid residue within a protein. [GOC:go_curators]", "GOMF_PROTEIN_PHOSPHATASE_BINDING": "Binding to a protein phosphatase. [GOC:jl]", "GOMF_PROTEIN_SEQUESTERING_ACTIVITY": "Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:1493333]", "GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a protein serine/threonine kinase. [GOC:go_curators]", "GOMF_PROTEIN_SERINE_THREONINE_KINASE_BINDING": "Binding to a protein serine/threonine kinase. [GOC:krc, GOC:sl, PMID:28608965]", "GOMF_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. [GOC:dph, GOC:tb]", "GOMF_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase. [GOC:mah]", "GOMF_PROTEIN_SERINE_KINASE_ACTIVITY": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]", "GOMF_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. [GOC:bf]", "GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY": "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [EC:2.7.11.-, GOC:bf, PMID:2956925]", "GOMF_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY": "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [GOC:mah]", "GOMF_PROTEIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY": "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. [GOC:ai, ISBN:0198506732]", "GOMF_PROTEIN_TRANSPORTER_ACTIVITY": "Directly binding to a specific protein and delivering it to a specific cellular location. [PMID:18706423]", "GOMF_PROTEIN_TYROSINE_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]", "GOMF_PROTEIN_TYROSINE_KINASE_INHIBITOR_ACTIVITY": "Stops, prevents or reduces the activity of a protein tyrosine kinase. [GOC:mah]", "GOMF_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]", "GOMF_PROTEIN_TYROSINE_KINASE_BINDING": "Binding to protein tyrosine kinase. [PMID:25499537]", "GOMF_PROTON_CHANNEL_ACTIVITY": "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "GOMF_PROTEIN_TYROSINE_THREONINE_PHOSPHATASE_ACTIVITY": "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]", "GOMF_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY": "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]", "GOMF_PROTEOGLYCAN_BINDING": "Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [ISBN:0198506732]", "GOMF_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM": "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). [RHEA:57722]", "GOMF_PROTON_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a proton from one side of a membrane to the other. [GOC:ai]", "GOMF_PSEUDOURIDINE_SYNTHASE_ACTIVITY": "Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [GOC:mah, RHEA:48348]", "GOMF_PURINE_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. [GOC:ai]", "GOMF_PURINE_RIBONUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other. [GOC:ai]", "GOMF_PYRIMIDINE_NUCLEOBASE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. [GOC:ai]", "GOMF_PYRIMIDINE_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other. [GOC:ai]", "GOMF_PYRIMIDINE_NUCLEOTIDE_BINDING": "Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate. [GOC:ai]", "GOMF_PYRIMIDINE_NUCLEOTIDE_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_PYRUVATE_DEHYDROGENASE_ACETYL_TRANSFERRING_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]. [RHEA:23052]", "GOMF_PYRUVATE_DEHYDROGENASE_ACETYL_TRANSFERRING_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate. [EC:3.1.3.43]", "GOMF_PYRUVATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other. [GOC:ai]", "GOMF_PURINE_NUCLEOTIDE_BINDING": "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. [GOC:ai]", "GOMF_PYRUVATE_DEHYDROGENASE_ACTIVITY": "", "GOMF_P_TYPE_CALCIUM_TRANSPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). [RHEA:18105]", "GOMF_P_TYPE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. [PMID:18075584, PMID:25918123]", "GOMF_P_TYPE_POTASSIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). [RHEA:16777]", "GOMF_QUATERNARY_AMMONIUM_GROUP_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [ISBN:0198506732]", "GOMF_QUINONE_BINDING": "Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. [ISBN:0198506732]", "GOMF_QUATERNARY_AMMONIUM_GROUP_BINDING": "Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [GOC:ai]", "GOMF_RACEMASE_AND_EPIMERASE_ACTIVITY": "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. [GOC:mah, ISBN:0198506732]", "GOMF_RACEMASE_AND_EPIMERASE_ACTIVITY_ACTING_ON_CARBOHYDRATES_AND_DERIVATIVES": "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. [EC:5.1.3.-, GOC:mah]", "GOMF_RAGE_RECEPTOR_BINDING": "Binding to a RAGE receptor, the receptor for advanced glycation end-products. [GOC:ai]", "GOMF_RDNA_BINDING": "Binding to a DNA sequence encoding a ribosomal RNA. [GOC:mah]", "GOMF_RECEPTOR_ANTAGONIST_ACTIVITY": "The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. [GOC:ceb, ISBN:0198506732]", "GOMF_RECEPTOR_SIGNALING_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a receptor signaling protein tyrosine kinase. [GOC:mah]", "GOMF_RECEPTOR_SERINE_THREONINE_KINASE_BINDING": "Binding to a receptor that possesses protein serine/threonine kinase activity. [GOC:mah]", "GOMF_RECEPTOR_TYROSINE_KINASE_BINDING": "Binding to a receptor that possesses protein tyrosine kinase activity. [GOC:mah]", "GOMF_RETINAL_DEHYDROGENASE_ACTIVITY": "", "GOMF_REGULATORY_RNA_BINDING": "Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme. [PMID:14622403, PMID:23475961]", "GOMF_RETINAL_BINDING": "Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. [ISBN:0198506732]", "GOMF_RETINOIC_ACID_4_HYDROXYLASE_ACTIVITY": "Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. [PMID:19519282, PMID:9250660]", "GOMF_RETINOIC_ACID_BINDING": "Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. [GOC:hjd]", "GOMF_RETINOIC_ACID_RESPONSIVE_ELEMENT_BINDING": "Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671]", "GOMF_RETINOL_BINDING": "Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. [GOC:curators]", "GOMF_RETINYL_PALMITATE_ESTERASE_ACTIVITY": "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+. [RHEA:21508]", "GOMF_RETROMER_COMPLEX_BINDING": "Binding to a retromer complex. [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27385586]", "GOMF_RIBOFLAVIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. [GOC:rn, PMID:16204239]", "GOMF_RIBONUCLEASE_P_ACTIVITY": "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. [EC:3.1.26.5]", "GOMF_RIBONUCLEASE_P_RNA_BINDING": "Binding to RNA subunit of ribonuclease P. [GOC:pg, PMID:11455963]", "GOMF_RIBOSE_PHOSPHATE_DIPHOSPHOKINASE_ACTIVITY": "", "GOMF_RIBOSOMAL_LARGE_SUBUNIT_BINDING": "Binding to a large ribosomal subunit. [GOC:go_curators]", "GOMF_RIBOSOMAL_SMALL_SUBUNIT_BINDING": "Binding to a small ribosomal subunit. [GOC:go_curators]", "GOMF_RIBONUCLEOPROTEIN_COMPLEX_BINDING": "Binding to a complex of RNA and protein. [GOC:bf, GOC:go_curators, GOC:vk]", "GOMF_RIBOSOMAL_PROTEIN_S6_KINASE_ACTIVITY": "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. [GOC:mah, PMID:9822608]", "GOMF_RISC_COMPLEX_BINDING": "Binding to a RISC complex. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24882364]", "GOMF_RNA_CAP_BINDING": "Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. [GOC:krc]", "GOMF_RIBOSOME_BINDING": "Binding to a ribosome. [GOC:go_curators]", "GOMF_RNA_2_O_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide. [PMID:30626973, RHEA:58956]", "GOMF_RNA_7_METHYLGUANOSINE_CAP_BINDING": "Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. [GOC:krc]", "GOMF_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY": "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. [EC:2.7.7.49]", "GOMF_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY": "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. [EC:3.1.26.4]", "GOMF_RNA_ENDONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS": "", "GOMF_RNA_EXONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. [GOC:mah, ISBN:0198547684]", "GOMF_RNA_ENDONUCLEASE_ACTIVITY_PRODUCING_3_PHOSPHOMONOESTERS": "", "GOMF_RNA_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. [GOC:mah]", "GOMF_RNA_ENDONUCLEASE_ACTIVITY": "Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. [GOC:mah, ISBN:0198547684]", "GOMF_RNA_POLYMERASE_ACTIVITY": "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. [GOC:pf]", "GOMF_RNA_NUCLEASE_ACTIVITY": "Catalysis of the cleavage of phosphodiester bonds in chains of RNA. [GOC:mah, ISBN:0198547684]", "GOMF_RNA_EXONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS": "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. [GOC:ai]", "GOMF_RNA_POLYMERASE_CORE_ENZYME_BINDING": "Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. [GOC:jl, GOC:txnOH]", "GOMF_RNA_POLYMERASE_BINDING": "Binding to an RNA polymerase molecule or complex. [GOC:BHF, GOC:mah, GOC:txnOH]", "GOMF_RNA_POLYMERASE_III_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY": "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III. [GOC:txnOH-2018, PMID:12381659, PMID:17977614, PMID:20413673, PMID:27068803, Wikipedia:RNA_polymerase_III]", "GOMF_RNA_POLYMERASE_III_ACTIVITY": "", "GOMF_RNA_POLYMERASE_III_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING": "Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. [GOC:txnOH, GOC:vw, PMID:12381659]", "GOMF_RNA_POLYMERASE_III_TYPE_3_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING": "", "GOMF_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING": "Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. [GOC:pg, GOC:txnOH, PMID:12381658]", "GOMF_RNA_POLYMERASE_II_CTD_HEPTAPEPTIDE_REPEAT_MODIFYING_ACTIVITY": "A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity. [GOC:pg]", "GOMF_RNA_POLYMERASE_II_ACTIVITY": "", "GOMF_RNA_POLYMERASE_II_CTD_HEPTAPEPTIDE_REPEAT_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. [EC:2.7.11.23, GOC:mah, PMID:28248323]", "GOMF_RNA_POLYMERASE_II_CTD_HEPTAPEPTIDE_REPEAT_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate. [PMID:22622228]", "GOMF_RNA_POLYMERASE_II_C_TERMINAL_DOMAIN_BINDING": "Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function. [PMID:20889714]", "GOMF_RNA_POLYMERASE_II_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_BINDING": "Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. [GOC:txnOH, PMID:16858867]", "GOMF_RNA_POLYMERASE_II_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING": "Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. [GOC:txnOH]", "GOMF_RNA_POLYMERASE_II_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY": "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]", "GOMF_RNA_POLYMERASE_I_ACTIVITY": "", "GOMF_RNA_POLYMERASE_II_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_BINDING": "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]", "GOMF_RNA_STEM_LOOP_BINDING": "Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. [GOC:sart, PMID:16568238, PMID:20455544]", "GOMF_RNA_POLYMERASE_I_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY": "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs. [GOC:txnOH-2018, PMID:11500378, PMID:17972917, PMID:25346433, PMID:28340337, PMID:28842442, PMID:31358304]", "GOMF_RNA_POLYMERASE_I_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_DNA_BINDING": "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I. [GOC:txnOH]", "GOMF_ROUNDABOUT_BINDING": "Binding to Roundabout (ROBO) receptor, a transmembrane receptor. [GOC:ecd, PMID:10102268, PMID:10197527]", "GOMF_RRNA_ADENINE_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. [GOC:go-curators]", "GOMF_RS_DOMAIN_BINDING": "Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. [PMID:11684676, PMID:12215544]", "GOMF_RRNA_CYTOSINE_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine. [GOC:go-curators]", "GOMF_RRNA_BINDING": "Binding to a ribosomal RNA. [GOC:jl]", "GOMF_R_SMAD_BINDING": "Binding to a receptor-regulated SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]", "GOMF_SALT_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of salt from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]", "GOMF_S100_PROTEIN_BINDING": "Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]", "GOMF_SCAVENGER_RECEPTOR_ACTIVITY": "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]", "GOMF_SECONDARY_ACTIVE_MONOCARBOXYLATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. [GOC:bf, GOC:jl]", "GOMF_SECONDARY_ACTIVE_SULFATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]", "GOMF_SCAFFOLD_PROTEIN_BINDING": "Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]", "GOMF_SEMAPHORIN_RECEPTOR_ACTIVITY": "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:15239958]", "GOMF_SELENIUM_BINDING": "Binding to a selenium (Se) ion. [GOC:ai]", "GOMF_SEMAPHORIN_RECEPTOR_BINDING": "Binding to a semaphorin receptor. [GOC:ceb, PMID:12001990]", "GOMF_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]", "GOMF_SEQUENCE_SPECIFIC_SINGLE_STRANDED_DNA_BINDING": "Binding to single-stranded DNA of a specific nucleotide composition. [PMID:9531483]", "GOMF_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]", "GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. [GOC:ai]", "GOMF_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]", "GOMF_SERINE_HYDROLASE_ACTIVITY": "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [Wikipedia:Serine_hydrolase]", "GOMF_SEROTONIN_BINDING": "Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:ai]", "GOMF_SEQUENCE_SPECIFIC_MRNA_BINDING": "Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif. [PMID:11886857]", "GOMF_SEROTONIN_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, PMID:12867984]", "GOMF_SEROTONIN_RECEPTOR_ACTIVITY": "Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:dos]", "GOMF_SEQUENCE_SPECIFIC_DNA_BINDING": "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl]", "GOMF_SH3_DOMAIN_BINDING": "Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]", "GOMF_SH2_DOMAIN_BINDING": "Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. [GOC:go_curators, Pfam:PF00017]", "GOMF_SHORT_CHAIN_CARBOXYLESTERASE_ACTIVITY": "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. [GOC:jp]", "GOMF_SHORT_CHAIN_FATTY_ACYL_COA_DEHYDROGENASE_ACTIVITY": "", "GOMF_SIALYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. [GOC:cjm, PMID:26192491]", "GOMF_SIALIC_ACID_BINDING": "Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria. [GOC:add, ISBN:9780721601465]", "GOMF_SIGNALING_RECEPTOR_COMPLEX_ADAPTOR_ACTIVITY": "The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. [GOC:mah]", "GOMF_SIGNALING_RECEPTOR_INHIBITOR_ACTIVITY": "Binds to and modulates the activity of a signaling receptor. [GOC:ceb]", "GOMF_SIGNALING_ADAPTOR_ACTIVITY": "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. [GOC:bf, PMID:19104498]", "GOMF_SINGLE_STRANDED_DNA_3_5_DNA_EXONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. [GOC:mah, PMID:22562358]", "GOMF_SIGNAL_RECOGNITION_PARTICLE_BINDING": "Binding to a signal recognition particle. [ISBN:0198506732]", "GOMF_SIGNAL_SEQUENCE_BINDING": "Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. [GOC:ai]", "GOMF_SIGNALING_RECEPTOR_BINDING": "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]", "GOMF_SINGLE_STRANDED_DNA_5_3_DNA_EXONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. [GOC:ai, GOC:elh, PMID:20086101]", "GOMF_SINGLE_STRANDED_DNA_BINDING": "Binding to single-stranded DNA. [GOC:elh, GOC:vw, PMID:22976174]", "GOMF_SINGLE_STRANDED_DNA_ENDODEOXYRIBONUCLEASE_ACTIVITY": "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. [GOC:mah]", "GOMF_SINGLE_STRANDED_DNA_EXODEOXYRIBONUCLEASE_ACTIVITY": "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. [GOC:mah]", "GOMF_SINGLE_STRANDED_DNA_HELICASE_ACTIVITY": "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. [GOC:jl]", "GOMF_SIGNALING_RECEPTOR_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a receptor. [GOC:ceb]", "GOMF_SIRNA_BINDING": "Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. [PMID:15066275, PMID:15066283]", "GOMF_SINGLE_STRANDED_RNA_BINDING": "Binding to single-stranded RNA. [GOC:jl]", "GOMF_SMALL_PROTEIN_ACTIVATING_ENZYME_BINDING": "Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme. [GOC:jl]", "GOMF_SMALL_MOLECULE_SENSOR_ACTIVITY": "", "GOMF_SMAD_BINDING": "Binding to a SMAD signaling protein. [GOC:ai]", "GOMF_SMALL_RIBOSOMAL_SUBUNIT_RRNA_BINDING": "Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. [GOC:elh]", "GOMF_SNAP_RECEPTOR_ACTIVITY": "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. [GOC:mah, PMID:14570579]", "GOMF_SNORNA_BINDING": "Binding to a small nucleolar RNA. [GOC:mah]", "GOMF_SNARE_BINDING": "Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. [PMID:12642621]", "GOMF_SNRNA_BINDING": "Binding to a small nuclear RNA (snRNA). [GOC:mah]", "GOMF_SNRNP_BINDING": "Binding to a small nuclear ribonucleoprotein particle. [GOC:BHF, GOC:mah, GOC:rl]", "GOMF_SODIUM_BICARBONATE_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). [TC:2.A.31.2.1]", "GOMF_SODIUM_CHANNEL_INHIBITOR_ACTIVITY": "Binds to and stops, prevents, or reduces the activity of a sodium channel. [GOC:mah]", "GOMF_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "", "GOMF_SODIUM_CHANNEL_ACTIVITY": "Enables the energy-independent facilitated diffusion of a sodium ion through a transmembrane aqueous pore or channel. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]", "GOMF_SODIUM_CHANNEL_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a sodium channel. [GOC:mah]", "GOMF_SODIUM_ION_BINDING": "Binding to a sodium ion (Na+). [GOC:mah]", "GOMF_SODIUM_PHOSPHATE_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). [TC:2.A.1.14.6]", "GOMF_SODIUM_PROTON_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). [TC:2.A.35.1.1, TC:2.A.36.-.-]", "GOMF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. [GOC:ai, GOC:BHF]", "GOMF_SOLUTE_INORGANIC_ANION_ANTIPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). [GOC:mah]", "GOMF_SOLUTE_POTASSIUM_ANTIPORTER_ACTIVITY": "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_SOLUTE_MONOATOMIC_CATION_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). [GOC:ai]", "GOMF_SOLUTE_PROTON_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). [GOC:ai]", "GOMF_SOMATOSTATIN_RECEPTOR_ACTIVITY": "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). [GOC:ai, GOC:bf, Wikipedia:Somatostatin]", "GOMF_SOLUTE_SODIUM_SYMPORTER_ACTIVITY": "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). [GOC:ai]", "GOMF_SPECTRIN_BINDING": "Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. [GOC:mah, ISBN:0198506732]", "GOMF_SPHINGOLIPID_TRANSFER_ACTIVITY": "Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]", "GOMF_SPHINGOLIPID_BINDING": "Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [ISBN:0198506732]", "GOMF_SPHINGOMYELIN_PHOSPHODIESTERASE_ACTIVITY": "Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+. [EC:3.1.4.12, RHEA:19253]", "GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY": "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:ai, ISBN:0198506732]", "GOMF_SPHINGOSINE_1_PHOSPHATE_PHOSPHATASE_ACTIVITY": "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. [GOC:jl, PMID:8663293]", "GOMF_SPHINGOSINE_1_PHOSPHATE_RECEPTOR_ACTIVITY": "Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, PMID:12728273, Wikipedia:S1PR1]", "GOMF_SPHINGOSINE_N_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]", "GOMF_SPLICING_FACTOR_BINDING": "Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA. [PMID:11118435]", "GOMF_STAT_FAMILY_PROTEIN_BINDING": "Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses. [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978]", "GOMF_STEROID_BINDING": "Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]", "GOMF_STEROID_DEHYDROGENASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR": "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. [GOC:mah]", "GOMF_STEROID_DEHYDROGENASE_ACTIVITY": "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. [GOC:mah]", "GOMF_STEROID_HYDROXYLASE_ACTIVITY": "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. [ISBN:0721662544]", "GOMF_STEROID_HORMONE_BINDING": "Binding to a steroid hormone. [GOC:ln]", "GOMF_STEROL_ESTERASE_ACTIVITY": "", "GOMF_STEROL_BINDING": "Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. [GOC:mah]", "GOMF_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY": "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]", "GOMF_STEROL_TRANSFER_ACTIVITY": "Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]", "GOMF_STRUCTURAL_CONSTITUENT_OF_CHROMATIN": "The action of a molecule that contributes to the structural integrity of chromatin. [GOC:ai]", "GOMF_STRUCTURAL_CONSTITUENT_OF_EYE_LENS": "The action of a molecule that contributes to the structural integrity of the lens of an eye. [GOC:mah]", "GOMF_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON": "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. [GOC:mah]", "GOMF_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE": "The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules. [GOC:mah, PMID:25802992]", "GOMF_STRUCTURAL_CONSTITUENT_OF_MYELIN_SHEATH": "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. [GOC:mah]", "GOMF_STRUCTURAL_CONSTITUENT_OF_MUSCLE": "The action of a molecule that contributes to the structural integrity of a muscle fiber. [GOC:mah]", "GOMF_STRUCTURAL_CONSTITUENT_OF_POSTSYNAPSE": "The action of a molecule that contributes to the structural integrity of a postsynapse. [GOC:dos]", "GOMF_STRUCTURAL_CONSTITUENT_OF_POSTSYNAPTIC_ACTIN_CYTOSKELETON": "The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton. [GOC:dos]", "GOMF_STRUCTURAL_CONSTITUENT_OF_SKIN_EPIDERMIS": "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure. [GOC:mah]", "GOMF_STRUCTURAL_CONSTITUENT_OF_SYNAPSE": "The action of a molecule that contributes to the structural integrity of a synapse. [GOC:dos]", "GOMF_STRUCTURAL_CONSTITUENT_OF_TOOTH_ENAMEL": "The action of a molecule that contributes to the structural integrity of tooth enamel. [GOC:mah]", "GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME": "The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah]", "GOMF_STRUCTURAL_MOLECULE_ACTIVITY_CONFERRING_ELASTICITY": "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling. [GOC:BHF, GOC:rl, PMID:23283722]", "GOMF_SUCCINATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other. [ISBN:0198506732]", "GOMF_SULFATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. [GOC:ai]", "GOMF_SULFATE_BINDING": "Binding to sulfate, SO4(2-), a negatively charged small molecule. [GOC:mlg]", "GOMF_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_SULFATIDE_BINDING": "Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group. [GOC:krc, PMID:21525289, PMID:22619219, PMID:22977233, PMID:23574804, PMID:29497057, PMID:3549017, Wikipedia:Sulfatide]", "GOMF_STRUCTURAL_MOLECULE_ACTIVITY": "The action of a molecule that contributes to the structural integrity of a complex. [GOC:mah, GOC:vw]", "GOMF_SULFURIC_ESTER_HYDROLASE_ACTIVITY": "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. [GOC:ai]", "GOMF_SULFOTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [EC:2.8.2.-]", "GOMF_SULFURTRANSFERASE_ACTIVITY": "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). [EC:2.8.1.-, GOC:ai]", "GOMF_SULFUR_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_SUMO_BINDING": "Binding to the small ubiquitin-like protein SUMO. [GOC:mah]", "GOMF_SUMO_LIGASE_ACTIVITY": "Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "GOMF_SULFUR_COMPOUND_BINDING": "Binding to a sulfur compound. [GOC:pr, GOC:TermGenie]", "GOMF_SUMO_POLYMER_BINDING": "Binding to a polymer of the small ubiquitin-like protein SUMO. [GOC:mah]", "GOMF_SUPERCOILED_DNA_BINDING": "Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil]", "GOMF_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a sulfur compound from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]", "GOMF_SUPEROXIDE_DISMUTASE_ACTIVITY": "", "GOMF_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase. [GOC:ai]", "GOMF_SUMO_TRANSFERASE_ACTIVITY": "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. [GOC:rn, PMID:11031248, PMID:11265250]", "GOMF_SUPEROXIDE_GENERATING_NAD_P_H_OXIDASE_ACTIVITY": "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. [GOC:ai, PMID:10806195]", "GOMF_SYNDECAN_BINDING": "Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. [GOC:go_curators, PMID:9355727]", "GOMF_SYNTAXIN_1_BINDING": "Binding to a syntaxin-1 SNAP receptor. [GOC:ai]", "GOMF_SYMPORTER_ACTIVITY": "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]", "GOMF_SYNTAXIN_BINDING": "Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. [ISBN:0198506732]", "GOMF_S_ACYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. [GOC:ai]", "GOMF_TAP_BINDING": "Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. [PMID:11133832]", "GOMF_S_ADENOSYL_L_METHIONINE_BINDING": "Binding to S-adenosyl-L-methionine. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]", "GOMF_S_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. [GOC:ai]", "GOMF_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. [GOC:mah]", "GOMF_TASTE_RECEPTOR_ACTIVITY": "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. [GOC:dph]", "GOMF_TAT_PROTEIN_BINDING": "Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. [GOC:mah, PMID:9094689]", "GOMF_TAURINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. [GOC:ai]", "GOMF_TAU_PROTEIN_BINDING": "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]", "GOMF_TAU_PROTEIN_KINASE_ACTIVITY": "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein on serine and threonine residues. [EC:2.7.11.26]", "GOMF_TBP_CLASS_PROTEIN_BINDING": "Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). [GOC:jl, GOC:txnOH, PMID:1509519, PMID:16858867]", "GOMF_TELETHONIN_BINDING": "Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. [GOC:mah, PMID:10481174]", "GOMF_TELOMERASE_ACTIVITY": "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) using an internal RNA template that encodes the telomeric repeat sequence. [GOC:krc, PMID:11812242, PMID:28732250]", "GOMF_TELOMERASE_RNA_BINDING": "Binding to the telomerase RNA template. [GOC:krc, PMID:16884717]", "GOMF_TELOMERASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of telomerase. [GOC:dph, GOC:krc, GOC:tb]", "GOMF_TESTOSTERONE_17_BETA_DEHYDROGENASE_NADPPLUS_ACTIVITY": "", "GOMF_TESTOSTERONE_DEHYDROGENASE_NADPLUS_ACTIVITY": "", "GOMF_TELOMERIC_DNA_BINDING": "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. [GOC:jl, SO:0000624]", "GOMF_TESTOSTERONE_DEHYDROGENASE_NAD_P_ACTIVITY": "", "GOMF_TFIID_CLASS_TRANSCRIPTION_FACTOR_COMPLEX_BINDING": "Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867]", "GOMF_THIAMINE_PYROPHOSPHATE_BINDING": "Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. [GOC:mlg]", "GOMF_THIAMINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_TETRAPYRROLE_BINDING": "Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. [GOC:curators, ISBN:0198506732]", "GOMF_THIOESTERASE_BINDING": "Binding to a thioesterase. [GOC:dl]", "GOMF_THIOLESTER_HYDROLASE_ACTIVITY": "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. [EC:3.1.2.-]", "GOMF_THIOL_OXIDASE_ACTIVITY": "Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2. [RHEA:17357]", "GOMF_THIOREDOXIN_DEPENDENT_PEROXIREDOXIN_ACTIVITY": "Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O. [PMID:12707274, PMID:19820102, RHEA:62620]", "GOMF_THREONINE_TYPE_ENDOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]", "GOMF_THIOREDOXIN_DISULFIDE_REDUCTASE_NADPH_ACTIVITY": "Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. [RHEA:20345]", "GOMF_THREONINE_TYPE_PEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]", "GOMF_THYROID_HORMONE_BINDING": "Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. [GOC:rph]", "GOMF_THYROID_HORMONE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:ai]", "GOMF_TOLL_LIKE_RECEPTOR_4_BINDING": "Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. [GOC:BHF, PMID:18304834]", "GOMF_TITIN_BINDING": "Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. [GOC:mah, PMID:10481174]", "GOMF_TORC2_COMPLEX_BINDING": "Binding to a TORC2 complex. [GOC:TermGenie, PMID:20660630]", "GOMF_TOLL_LIKE_RECEPTOR_BINDING": "Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. [PMID:19076341]", "GOMF_TOXIC_SUBSTANCE_BINDING": "Binding to a toxic substance, a poisonous substance that causes damage to biological systems. [GOC:bf, GOC:curators, GOC:jl, GOC:pr]", "GOMF_TPR_DOMAIN_BINDING": "Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. [GOC:mah]", "GOMF_TOXIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [ISBN:0198506732]", "GOMF_TRAIL_BINDING": "Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. [GOC:go_curators, PMID:9082980]", "GOMF_TRACE_AMINE_RECEPTOR_ACTIVITY": "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. [GOC:mah, PMID:19325074]", "GOMF_TRANSCRIPTION_COACTIVATOR_ACTIVITY": "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]", "GOMF_TRANSCRIPTION_COACTIVATOR_BINDING": "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. [GOC:krc]", "GOMF_TRANSCRIPTION_ELONGATION_FACTOR_ACTIVITY": "A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases. [GOC:txnOH-2018, PMID:23878398, PMID:28892040]", "GOMF_TRANSCRIPTION_COREGULATOR_BINDING": "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. [GOC:krc]", "GOMF_TRANSCRIPTION_COREPRESSOR_ACTIVITY": "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]", "GOMF_TRANSCRIPTION_COREPRESSOR_BINDING": "Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc]", "GOMF_TRANSCRIPTION_COREGULATOR_ACTIVITY": "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]", "GOMF_TRANSCRIPTION_REGULATOR_ACTIVATOR_ACTIVITY": "A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification. [PMID:9597751]", "GOMF_TRANSCRIPTION_FACTOR_BINDING": "Binding to a transcription factor, a protein required to initiate or regulate transcription. [ISBN:0198506732]", "GOMF_TRANSCRIPTION_REGULATOR_INHIBITOR_ACTIVITY": "A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. [PMID:10652346]", "GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS": "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). [EC:2.5.1.-]", "GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS": "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]", "GOMF_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING": "Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. [ISBN:0198506732]", "GOMF_TRANSFERRIN_RECEPTOR_BINDING": "Binding to a transferrin receptor. [GOC:pm, PMID:9819414]", "GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_SULPHUR_CONTAINING_GROUPS": "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). [EC:2.8.-.-]", "GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS": "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]", "GOMF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_ACTIVITY": "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:mah, GOC:signaling]", "GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY": "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons. [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]", "GOMF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_ACTIVITY_TYPE_I": "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. [GOC:mah]", "GOMF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING": "Binding to a transforming growth factor beta receptor. [GOC:ai]", "GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS": "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). [EC:2.7.-.-]", "GOMF_TRANSKETOLASE_OR_TRANSALDOLASE_ACTIVITY": "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]", "GOMF_TRANSLATION_ACTIVATOR_ACTIVITY": "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai]", "GOMF_TRANSLATION_ELONGATION_FACTOR_ACTIVITY": "Functions in chain elongation during polypeptide synthesis at the ribosome. [ISBN:0198506732]", "GOMF_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732]", "GOMF_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING": "Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. [GOC:ai, GOC:vw]", "GOMF_TRANSITION_METAL_ION_BINDING": "Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732]", "GOMF_TRANSLATION_INITIATION_FACTOR_ACTIVITY": "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. [ISBN:0198506732]", "GOMF_TRANSLATION_INITIATION_FACTOR_BINDING": "Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. [GOC:mah]", "GOMF_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING": "", "GOMF_TRANSLATION_REGULATOR_ACTIVITY": "Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. [GOC:ai]", "GOMF_TRANSLATION_REPRESSOR_ACTIVITY": "Antagonizes ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai, GOC:clt]", "GOMF_TRANSMEMBRANE_EPHRIN_RECEPTOR_ACTIVITY": "Combining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]", "GOMF_TRANSLATION_TERMINATION_FACTOR_ACTIVITY": "Functions in the termination of translation. [GOC:ma]", "GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. [GOC:hjd]", "GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:mah]", "GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_BINDING": "Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity. [GOC:BHF, GOC:mah]", "GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [RHEA:18673]", "GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase. [GOC:mah]", "GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ADAPTOR_ACTIVITY": "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848]", "GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY": "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [EC:2.7.10.1, GOC:mah]", "GOMF_TRANSPORTER_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a transporter. [GOC:curators]", "GOMF_TRANSMEMBRANE_TRANSPORTER_BINDING": "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]", "GOMF_TRANSPORTER_INHIBITOR_ACTIVITY": "Binds to and stops, prevents, or reduces the activity of a transporter. [GOC:curators]", "GOMF_TRIPEPTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other. [GOC:jl]", "GOMF_TRIGLYCERIDE_LIPASE_ACTIVITY": "", "GOMF_TRANSPORTER_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a transporter. [GOC:curators]", "GOMF_TRIPLET_CODON_AMINO_ACID_ADAPTOR_ACTIVITY": "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis. [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732]", "GOMF_TRNA_CYTIDINE_5_METHYLTRANSFERASE_ACTIVITY": "", "GOMF_TRNA_BINDING": "Binding to a transfer RNA. [GOC:ai]", "GOMF_TRNA_CYTIDINE_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine. [GOC:go-curators]", "GOMF_TRANSPORTER_ACTIVITY": "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. [GOC:ai, GOC:dgf]", "GOMF_TRNA_GUANINE_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. [GOC:go-curators]", "GOMF_TRNA_PSEUDOURIDINE_SYNTHASE_ACTIVITY": "Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [PMID:11095668]", "GOMF_TRNA_SPECIFIC_ADENOSINE_DEAMINASE_ACTIVITY": "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule. [GOC:mah]", "GOMF_TRNA_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. [GOC:mah]", "GOMF_TRNA_URIDINE_METHYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. [GOC:mah]", "GOMF_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY": "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. [GOC:mah]", "GOMF_TROPOMYOSIN_BINDING": "Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. [GOC:curators, ISBN:0815316194]", "GOMF_TUMOR_NECROSIS_FACTOR_BINDING": "Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. [GOC:jl, http://lookwayup.com/]", "GOMF_TUMOR_NECROSIS_FACTOR_RECEPTOR_ACTIVITY": "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. [GOC:jl, http://lookwayup.com/]", "GOMF_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING": "Binding to a tumor necrosis factor receptor. [GOC:ai]", "GOMF_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING": "Binding to a member of the tumor necrosis factor receptor superfamily. [GOC:add]", "GOMF_TYPE_1_ANGIOTENSIN_RECEPTOR_BINDING": "Binding to a type 1 angiotensin receptor. [GOC:mah, GOC:nln]", "GOMF_TYPE_1_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to a type 1 fibroblast growth factor receptor (FGFR1). [GOC:ceb, GOC:fb_curators]", "GOMF_TUBULIN_BINDING": "Binding to monomeric or multimeric forms of tubulin, including microtubules. [GOC:clt]", "GOMF_TYPE_5_METABOTROPIC_GLUTAMATE_RECEPTOR_BINDING": "", "GOMF_TYPE_2_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to a type 2 fibroblast growth factor receptor (FGFR2). [GOC:fb_curators]", "GOMF_TYPE_I_INTERFERON_RECEPTOR_BINDING": "Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). [GOC:ai, GOC:signaling, PMID:17502368]", "GOMF_TYPE_II_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING": "Binding to a type II transforming growth factor beta receptor. [GOC:ceb, GOC:mah, PMID:11252892]", "GOMF_TYPE_I_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING": "Binding to a type I transforming growth factor beta receptor. [GOC:BHF, GOC:mah]", "GOMF_T_CELL_RECEPTOR_BINDING": "Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. [GOC:jl]", "GOMF_U1_SNRNP_BINDING": "Binding to a U1 small nuclear ribonucleoprotein particle. [PMID:14713954]", "GOMF_U2_SNRNA_BINDING": "Binding to a U2 small nuclear RNA (U2 snRNA). [GOC:jl]", "GOMF_U1_SNRNA_BINDING": "Binding to a U1 small nuclear RNA (U1 snRNA). [GOC:mah]", "GOMF_U3_SNORNA_BINDING": "Binding to a U3 small nucleolar RNA. [GOC:mah]", "GOMF_U4_SNRNA_BINDING": "Binding to a U4 small nuclear RNA (U4 snRNA). [GOC:jl]", "GOMF_UBIQUINOL_CYTOCHROME_C_REDUCTASE_ACTIVITY": "", "GOMF_U6_SNRNA_BINDING": "Binding to a U6 small nuclear RNA (U6 snRNA). [GOC:mah]", "GOMF_UBIQUITIN_CONJUGATING_ENZYME_BINDING": "Binding to a ubiquitin conjugating enzyme, any of the E2 proteins. [GOC:vp]", "GOMF_UBIQUINONE_BINDING": "Binding to ubiquinone, a quinone derivative with a tail of isoprene units. [GOC:jid, ISBN:0582227089]", "GOMF_UBIQUITIN_BINDING": "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. [GOC:ecd]", "GOMF_UBIQUITIN_LIGASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a ubiquitin ligase. [GOC:dph, PMID:25619242]", "GOMF_UBIQUITIN_LIGASE_COMPLEX_SCAFFOLD_ACTIVITY": "The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way. [PMID:27664236]", "GOMF_UBIQUITIN_LIGASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase. [GOC:dph, GOC:vw, PMID:21389117]", "GOMF_UBIQUITIN_LIKE_MODIFIER_ACTIVATING_ENZYME_ACTIVITY": "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:jl, GOC:mah]", "GOMF_UBIQUITIN_LIKE_LIGASE_SUBSTRATE_ADAPTOR_ACTIVITY": "The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins. [PMID:24658274]", "GOMF_UBIQUITIN_LIKE_PROTEIN_BINDING": "Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein. [GOC:mah]", "GOMF_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING": "Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. [GOC:jl]", "GOMF_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY": "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. [GOC:dph]", "GOMF_UBIQUITIN_LIKE_PROTEIN_READER_ACTIVITY": "A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. [PMID:26060076]", "GOMF_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_ENDOPEPTIDASE_ACTIVITY": "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO). [GOC:mah]", "GOMF_UBIQUITIN_LIKE_PROTEIN_PEPTIDASE_ACTIVITY": "An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins. [PMID:19489724]", "GOMF_UBIQUITIN_MODIFIED_HISTONE_READER_ACTIVITY": "A histone reader that recognizes a histone bearing a ubiquinated lysine residue. [PMID:24526689]", "GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY": "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]", "GOMF_UBIQUITIN_PROTEIN_TRANSFERASE_ACTIVATOR_ACTIVITY": "Binds to and increases the activity of a ubiquitin-protein transferase. [GOC:rb, PMID:18321851]", "GOMF_UBIQUITIN_PROTEIN_TRANSFERASE_INHIBITOR_ACTIVITY": "Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase. [GOC:BHF, GOC:rl]", "GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING": "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. [GOC:jl]", "GOMF_UBIQUITIN_SPECIFIC_PROTEASE_BINDING": "Binding to a ubiquitin-specific protease. [GOC:bf, GOC:PARL, PMID:24063750]", "GOMF_UBIQUITIN_PROTEIN_TRANSFERASE_REGULATOR_ACTIVITY": "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. [GOC:BHF, GOC:rl]", "GOMF_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY": "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]", "GOMF_UDP_GALACTOSE_BETA_N_ACETYLGLUCOSAMINE_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY": "", "GOMF_UDP_GLUCOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. [PMID:19858195]", "GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. [PMID:11846783]", "GOMF_UDP_XYLOSYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. [PMID:30127001]", "GOMF_UDP_N_ACETYLGLUCOSAMINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]", "GOMF_UNIPORTER_ACTIVITY": "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]", "GOMF_UREA_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2. [ISBN:0198506732]", "GOMF_UNMETHYLATED_CPG_BINDING": "Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters. [GOC:ai, PMID:10688657]", "GOMF_UNFOLDED_PROTEIN_BINDING": "Binding to an unfolded protein. [GOC:ai]", "GOMF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_BINDING": "Binding to a vascular endothelial growth factor. [PMID:17470632]", "GOMF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_2_BINDING": "Binding to a vascular endothelial growth factor receptor 2. [GOC:st]", "GOMF_URIDYLYLTRANSFERASE_ACTIVITY": "Catalysis of the transfer of an uridylyl group to an acceptor. [GOC:mah]", "GOMF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_ACTIVITY": "Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:19909239]", "GOMF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_BINDING": "Binding to a vascular endothelial growth factor receptor. [GOC:ai]", "GOMF_VASOPRESSIN_RECEPTOR_ACTIVITY": "Combining with vasopressin to initiate a change in cell activity. [GOC:ai]", "GOMF_VERY_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY": "Catalysis of the reaction: a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. [PMID:18024425, RHEA:54536]", "GOMF_VINCULIN_BINDING": "Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. [ISBN:0721662544]", "GOMF_VIRION_BINDING": "Binding to a virion, either by binding to components of the capsid or the viral envelope. [GOC:ai]", "GOMF_VITAMIN_B6_BINDING": "Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate. [GOC:mah]", "GOMF_VITAMIN_D_BINDING": "Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]", "GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of a vitamin from one side of a membrane to the other. [GOC:tb]", "GOMF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY_INVOLVED_IN_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOMF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]", "GOMF_VITAMIN_BINDING": "Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]", "GOMF_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_VOLTAGE_GATED_MONOATOMIC_ANION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:vw, ISBN:0815340729]", "GOMF_VOLTAGE_GATED_MONOATOMIC_ION_CHANNEL_ACTIVITY_INVOLVED_IN_REGULATION_OF_PRESYNAPTIC_MEMBRANE_POTENTIAL": "Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. [GOC:dos]", "GOMF_VOLTAGE_GATED_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_VOLTAGE_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY_INVOLVED_IN_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL_REPOLARIZATION": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]", "GOMF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY_INVOLVED_IN_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL_REPOLARIZATION": "", "GOMF_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY_INVOLVED_IN_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL": "", "GOMF_VOLUME_SENSITIVE_ANION_CHANNEL_ACTIVITY": "Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. [GOC:dph, GOC:tb]", "GOMF_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of water (H2O) from one side of a membrane to the other. [GOC:ai]", "GOMF_WD40_REPEAT_DOMAIN_BINDING": "Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain. [GOC:yaf, InterPro:IPR017986]", "GOMF_WNT_PROTEIN_BINDING": "Binding to a Wnt-protein, a secreted growth factor involved in signaling. [GOC:jl]", "GOMF_WNT_RECEPTOR_ACTIVITY": "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:go_curators]", "GOMF_WIDE_PORE_CHANNEL_ACTIVITY": "Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. [GOC:mtg_transport, ISBN:0815340729]", "GOMF_WW_DOMAIN_BINDING": "Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. [PMID:14531730]", "GOMF_XMP_5_NUCLEOSIDASE_ACTIVITY": "", "GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]", "GOMF_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY": "Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. [GOC:dgf]", "HP_2_3_FINGER_SYNDACTYLY": "", "HP_11_PAIRS_OF_RIBS": "11 pairs of ribs", "HP_2_3_TOE_CUTANEOUS_SYNDACTYLY": "2-3 toe cutaneous syndactyly", "HP_2_4_TOE_CUTANEOUS_SYNDACTYLY": "2-4 toe cutaneous syndactyly", "GOMF_ZINC_ION_BINDING": "Binding to a zinc ion (Zn). [GOC:ai]", "HP_2_4_FINGER_SYNDACTYLY": "", "HP_2_3_TOE_SYNDACTYLY": "2-3 toe syndactyly", "HP_2_HYDROXYGLUTARATE_ACIDURIA": "2-hydroxyglutarate aciduria", "HP_3_4_FINGER_CUTANEOUS_SYNDACTYLY": "3-4 finger cutaneous syndactyly", "HP_3_METHYLGLUTACONIC_ACIDURIA": "3-Methylglutaconic aciduria", "HP_3_METHYLGLUTARIC_ACIDURIA": "3-Methylglutaric aciduria", "HP_3_4_FINGER_SYNDACTYLY": "", "HP_3_4_TOE_SYNDACTYLY": "3-4 toe syndactyly", "HP_ABDOMINAL_AORTIC_ANEURYSM": "Abdominal aortic aneurysm", "HP_4_5_TOE_SYNDACTYLY": "4-5 toe syndactyly", "HP_4_5_FINGER_SYNDACTYLY": "", "HP_ABDOMINAL_COLIC": "Abdominal colic", "HP_ABDOMINAL_CRAMPS": "Abdominal cramps", "HP_ABDOMINAL_DISTENTION": "Abdominal distention", "HP_ABDOMINAL_SITUS_AMBIGUUS": "Abdominal situs ambiguus", "HP_ABDOMINAL_MASS": "Abdominal mass", "HP_ABDOMINAL_OBESITY": "Abdominal obesity", "HP_ABDOMINAL_SITUS_INVERSUS": "Abdominal situs inversus", "HP_ABLEPHARON": "Ablepharon", "HP_ABDOMINAL_PAIN": "Abdominal pain", "HP_ABDUCENS_PALSY": "Abducens palsy", "HP_ABDOMINAL_WALL_MUSCLE_WEAKNESS": "Abdominal wall muscle weakness", "HP_ABNORMALITIES_OF_PLACENTA_OR_UMBILICAL_CORD": "Abnormalities of placenta or umbilical cord", "HP_ABNORMALITY_OF_ABDOMINAL_SITUS": "Abnormality of abdominal situs", "HP_ABNORMALITY_OF_ALKALINE_PHOSPHATASE_LEVEL": "Abnormality of alkaline phosphatase level", "HP_ABNORMALITY_OF_ADRENAL_PHYSIOLOGY": "Abnormality of adrenal physiology", "HP_ABNORMALITY_OF_ACID_BASE_HOMEOSTASIS": "Abnormality of acid-base homeostasis", "HP_ABNORMALITY_IRIS_MORPHOLOGY": "Abnormality iris morphology", "HP_ABNORMALITY_OF_CANINE": "Abnormality of canine", "HP_ABNORMALITY_OF_AMINO_ACID_METABOLISM": "Abnormality of amino acid metabolism", "HP_ABNORMALITY_OF_BODY_MASS_INDEX": "Abnormality of body mass index", "HP_ABNORMALITY_OF_BLOOD_CIRCULATION": "Abnormality of blood circulation", "HP_ABNORMALITY_OF_CARTILAGE_OF_EXTERNAL_EAR": "", "HP_ABNORMALITY_OF_CHORIORETINAL_PIGMENTATION": "Abnormality of chorioretinal pigmentation", "HP_ABNORMALITY_OF_BONE_MINERAL_DENSITY": "Abnormality of bone mineral density", "HP_ABNORMALITY_OF_CHROMOSOME_SEGREGATION": "Abnormality of chromosome segregation", "HP_ABNORMALITY_OF_BLOOD_AND_BLOOD_FORMING_TISSUES": "Abnormality of blood and blood-forming tissues", "HP_ABNORMALITY_OF_CHROMOSOME_STABILITY": "Abnormality of chromosome stability", "HP_ABNORMALITY_OF_CARDIOVASCULAR_SYSTEM_ELECTROPHYSIOLOGY": "Abnormality of cardiovascular system electrophysiology", "HP_ABNORMALITY_OF_CIRCULATING_FIBRINOGEN": "Abnormality of circulating fibrinogen", "HP_ABNORMALITY_OF_CIRCULATING_GLUCOCORTICOID_LEVEL": "Abnormality of circulating glucocorticoid level", "HP_ABNORMALITY_OF_CENTRAL_NERVOUS_SYSTEM_ELECTROPHYSIOLOGY": "Abnormality of central nervous system electrophysiology", "HP_ABNORMALITY_OF_COAGULATION": "Abnormality of coagulation", "HP_ABNORMALITY_OF_COMPLEMENT_SYSTEM": "Abnormality of complement system", "HP_ABNORMALITY_OF_CORNEAL_THICKNESS": "", "HP_ABNORMALITY_OF_CYTOKINE_SECRETION": "Abnormality of cytokine secretion", "HP_ABNORMALITY_OF_DENTAL_COLOR": "Abnormality of dental color", "HP_ABNORMALITY_OF_CORNEAL_SIZE": "Abnormality of corneal size", "HP_ABNORMALITY_OF_COORDINATION": "Abnormality of coordination", "HP_ABNORMALITY_OF_DERMAL_MELANOSOMES": "Abnormality of dermal melanosomes", "HP_ABNORMALITY_OF_CRANIAL_SUTURES": "Abnormality of cranial sutures", "HP_ABNORMALITY_OF_CONNECTIVE_TISSUE": "Abnormality of connective tissue", "HP_ABNORMALITY_OF_DENTAL_ERUPTION": "Abnormality of dental eruption", "HP_ABNORMALITY_OF_DNA_REPAIR": "Abnormality of DNA repair", "HP_ABNORMALITY_OF_ENDOCRINE_PANCREAS_PHYSIOLOGY": "Abnormality of endocrine pancreas physiology", "HP_ABNORMALITY_OF_DENTAL_STRUCTURE": "Abnormality of dental structure", "HP_ABNORMALITY_OF_EXOCRINE_PANCREAS_PHYSIOLOGY": "", "HP_ABNORMALITY_OF_FIBRINOLYSIS": "Abnormality of fibrinolysis", "HP_ABNORMALITY_OF_FACIAL_ADIPOSE_TISSUE": "Abnormality of facial adipose tissue", "HP_ABNORMALITY_OF_FOLATE_METABOLISM": "Abnormality of folate metabolism", "HP_ABNORMALITY_OF_EXTRAPYRAMIDAL_MOTOR_FUNCTION": "Abnormality of extrapyramidal motor function", "HP_ABNORMALITY_OF_FACIAL_MUSCULATURE": "Abnormality of facial musculature", "HP_ABNORMALITY_OF_FOVEAL_PIGMENTATION": "", "HP_ABNORMALITY_OF_FRONTAL_SINUS": "Abnormality of frontal sinus", "HP_ABNORMALITY_OF_FONTANELLES": "", "HP_ABNORMALITY_OF_FACIAL_SOFT_TISSUE": "Abnormality of facial soft tissue", "HP_ABNORMALITY_OF_FLUID_REGULATION": "Abnormality of fluid regulation", "HP_ABNORMALITY_OF_FUNDUS_PIGMENTATION": "", "HP_ABNORMALITY_OF_GLYCOLIPID_METABOLISM": "Abnormality of glycolipid metabolism", "HP_ABNORMALITY_OF_HAIR_GROWTH": "Abnormality of hair growth", "HP_ABNORMALITY_OF_HAIR_PIGMENTATION": "Abnormality of hair pigmentation", "HP_ABNORMALITY_OF_HEPATOBILIARY_SYSTEM_PHYSIOLOGY": "", "HP_ABNORMALITY_OF_HAND_JOINT_MOBILITY": "Abnormality of hand joint mobility", "HP_ABNORMALITY_OF_GLOBE_LOCATION": "Abnormality of globe location", "HP_ABNORMALITY_OF_HAIR_TEXTURE": "Abnormality of hair texture", "HP_ABNORMALITY_OF_IMMUNE_SYSTEM_PHYSIOLOGY": "", "HP_ABNORMALITY_OF_INTRACRANIAL_PRESSURE": "", "HP_ABNORMALITY_OF_IRON_HOMEOSTASIS": "Abnormality of iron homeostasis", "HP_ABNORMALITY_OF_JAW_MUSCLES": "Abnormality of jaw muscles", "HP_ABNORMALITY_OF_HUMORAL_IMMUNITY": "Abnormality of humoral immunity", "HP_ABNORMALITY_OF_KREBS_CYCLE_METABOLISM": "Abnormality of Krebs cycle metabolism", "HP_ABNORMALITY_OF_LENS_SHAPE": "Abnormality of lens shape", "HP_ABNORMALITY_OF_LIMB_BONE": "", "HP_ABNORMALITY_OF_LOWER_EYELASHES": "Abnormality of lower eyelashes", "HP_ABNORMALITY_OF_LIPOPROTEIN_CHOLESTEROL_CONCENTRATION": "Abnormality of lipoprotein cholesterol concentration", "HP_ABNORMALITY_OF_LYSOSOMAL_METABOLISM": "Abnormality of lysosomal metabolism", "HP_ABNORMALITY_OF_MASSETER_MUSCLE": "Abnormality of masseter muscle", "HP_ABNORMALITY_OF_MACULAR_PIGMENTATION": "", "HP_ABNORMALITY_OF_JOINT_MOBILITY": "Abnormality of joint mobility", "HP_ABNORMALITY_OF_NAIL_COLOR": "Abnormality of nail color", "HP_ABNORMALITY_OF_MOUTH_SHAPE": "Abnormality of mouth shape", "HP_ABNORMALITY_OF_LOWER_LIMB_JOINT": "Abnormality of lower limb joint", "HP_ABNORMALITY_OF_MULTIPLE_CELL_LINEAGES_IN_THE_BONE_MARROW": "Abnormality of multiple cell lineages in the bone marrow", "HP_ABNORMALITY_OF_NEUTROPHIL_PHYSIOLOGY": "", "HP_ABNORMALITY_OF_MOUTH_SIZE": "Abnormality of mouth size", "HP_ABNORMALITY_OF_MUSCLE_SIZE": "Abnormality of muscle size", "HP_ABNORMALITY_OF_OCULAR_ABDUCTION": "Abnormality of ocular abduction", "HP_ABNORMALITY_OF_NEURONAL_MIGRATION": "Abnormality of neuronal migration", "HP_ABNORMALITY_OF_NEUTROPHILS": "Abnormality of neutrophils", "HP_ABNORMALITY_OF_OCULAR_SMOOTH_PURSUIT": "Abnormality of ocular smooth pursuit", "HP_ABNORMALITY_OF_PAIN_SENSATION": "Abnormality of pain sensation", "HP_ABNORMALITY_OF_PERIPHERAL_NERVE_CONDUCTION": "", "HP_ABNORMALITY_OF_PATTERN_VISUAL_EVOKED_POTENTIALS": "Abnormality of pattern visual evoked potentials", "HP_ABNORMALITY_OF_PREMOLAR": "", "HP_ABNORMALITY_OF_PANCREAS_PHYSIOLOGY": "Abnormality of pancreas physiology", "HP_ABNORMALITY_OF_PRIMARY_TEETH": "Abnormality of primary teeth", "HP_ABNORMALITY_OF_RADIAL_EPIPHYSES": "", "HP_ABNORMALITY_OF_PROTHROMBIN": "Abnormality of prothrombin", "HP_ABNORMALITY_OF_PULMONARY_CIRCULATION": "Abnormality of pulmonary circulation", "HP_ABNORMALITY_OF_PRENATAL_DEVELOPMENT_OR_BIRTH": "Abnormality of prenatal development or birth", "HP_ABNORMALITY_OF_RENAL_EXCRETION": "Abnormality of renal excretion", "HP_ABNORMALITY_OF_RENIN_ANGIOTENSIN_SYSTEM": "Abnormality of renin-angiotensin system", "HP_ABNORMALITY_OF_RETINAL_PIGMENTATION": "", "HP_ABNORMALITY_OF_REFRACTION": "Abnormality of refraction", "HP_ABNORMALITY_OF_SALIVATION": "Abnormality of salivation", "HP_ABNORMALITY_OF_SECONDARY_SEXUAL_HAIR": "Abnormality of secondary sexual hair", "HP_ABNORMALITY_OF_REPRODUCTIVE_SYSTEM_PHYSIOLOGY": "Abnormality of reproductive system physiology", "HP_ABNORMALITY_OF_SKELETAL_MATURATION": "Abnormality of skeletal maturation", "HP_ABNORMALITY_OF_SKELETAL_MUSCLE_FIBER_SIZE": "Abnormality of skeletal muscle fiber size", "HP_ABNORMALITY_OF_SKULL_OSSIFICATION": "Abnormality of skull ossification", "HP_ABNORMALITY_OF_SOMATOSENSORY_EVOKED_POTENTIALS": "Abnormality of somatosensory evoked potentials", "HP_ABNORMALITY_OF_SPINAL_FACET_JOINT": "Abnormality of spinal facet joint", "HP_ABNORMALITY_OF_TASTE_SENSATION": "Abnormality of taste sensation", "HP_ABNORMALITY_OF_SKIN_PIGMENTATION": "Abnormality of skin pigmentation", "HP_ABNORMALITY_OF_SUBCUTANEOUS_FAT_TISSUE": "Abnormality of subcutaneous fat tissue", "HP_ABNORMALITY_OF_THE_ABDOMINAL_WALL": "", "HP_ABNORMALITY_OF_THE_ACHILLES_TENDON": "", "HP_ABNORMALITY_OF_SKIN_PHYSIOLOGY": "Abnormality of skin physiology", "HP_ABNORMALITY_OF_TEMPERATURE_REGULATION": "Abnormality of temperature regulation", "HP_ABNORMALITY_OF_THE_ACOUSTIC_REFLEX": "Abnormality of the acoustic reflex", "HP_ABNORMALITY_OF_THE_ABDOMINAL_ORGANS": "Abnormality of the abdominal organs", "HP_ABNORMALITY_OF_THE_ADRENAL_GLANDS": "Abnormality of the adrenal glands", "HP_ABNORMALITY_OF_THE_ANTERIOR_COMMISSURE": "Abnormality of the anterior commissure", "HP_ABNORMALITY_OF_THE_ANKLE": "Abnormality of the ankle", "HP_ABNORMALITY_OF_THE_ANTERIOR_FONTANELLE": "", "HP_ABNORMALITY_OF_THE_AMNIOTIC_FLUID": "Abnormality of the amniotic fluid", "HP_ABNORMALITY_OF_THE_AXILLARY_HAIR": "Abnormality of the axillary hair", "HP_ABNORMALITY_OF_THE_ANUS": "Abnormality of the anus", "HP_ABNORMALITY_OF_THE_AUTONOMIC_NERVOUS_SYSTEM": "Abnormality of the autonomic nervous system", "HP_ABNORMALITY_OF_THE_BILIARY_SYSTEM": "Abnormality of the biliary system", "HP_ABNORMALITY_OF_THE_CALCANEUS": "Abnormality of the calcaneus", "HP_ABNORMALITY_OF_THE_BLADDER": "Abnormality of the bladder", "HP_ABNORMALITY_OF_THE_BREAST": "Abnormality of the breast", "HP_ABNORMALITY_OF_THE_CALF": "Abnormality of the calf", "HP_ABNORMALITY_OF_THE_CERVICAL_SPINE": "Abnormality of the cervical spine", "HP_ABNORMALITY_OF_THE_COMMON_COAGULATION_PATHWAY": "Abnormality of the common coagulation pathway", "HP_ABNORMALITY_OF_THE_CHIN": "Abnormality of the chin", "HP_ABNORMALITY_OF_THE_COSTOCHONDRAL_JUNCTION": "Abnormality of the costochondral junction", "HP_ABNORMALITY_OF_THE_CRUS_OF_THE_HELIX": "Abnormality of the crus of the helix", "HP_ABNORMALITY_OF_THE_COAGULATION_CASCADE": "Abnormality of the coagulation cascade", "HP_ABNORMALITY_OF_THE_DIENCEPHALON": "", "HP_ABNORMALITY_OF_THE_DIAPHRAGM": "Abnormality of the diaphragm", "HP_ABNORMALITY_OF_THE_DISTAL_PHALANGES_OF_THE_TOES": "Abnormality of the distal phalanges of the toes", "HP_ABNORMALITY_OF_THE_CURVATURE_OF_THE_CORNEA": "Abnormality of the curvature of the cornea", "HP_ABNORMALITY_OF_THE_DISTAL_PHALANX_OF_THE_2ND_FINGER": "Abnormality of the distal phalanx of the 2nd finger", "HP_ABNORMALITY_OF_THE_DISTAL_PHALANX_OF_THE_3RD_FINGER": "Abnormality of the distal phalanx of the 3rd finger", "HP_ABNORMALITY_OF_THE_DISTAL_PHALANX_OF_THE_HALLUX": "Abnormality of the distal phalanx of the hallux", "HP_ABNORMALITY_OF_THE_DISTAL_PHALANX_OF_THE_THUMB": "Abnormality of the distal phalanx of the thumb", "HP_ABNORMALITY_OF_THE_DENTITION": "Abnormality of the dentition", "HP_ABNORMALITY_OF_THE_DISTAL_PHALANX_OF_THE_5TH_FINGER": "Abnormality of the distal phalanx of the 5th finger", "HP_ABNORMALITY_OF_THE_DORSAL_COLUMN_OF_THE_SPINAL_CORD": "", "HP_ABNORMALITY_OF_THE_EPIPHYSES_OF_THE_DISTAL_PHALANX_OF_FINGER": "Abnormality of the epiphyses of the distal phalanx of finger", "HP_ABNORMALITY_OF_THE_EPIPHYSES_OF_THE_PROXIMAL_PHALANGES_OF_THE_HAND": "Abnormality of the epiphyses of the proximal phalanges of the hand", "HP_ABNORMALITY_OF_THE_EPIPHYSES_OF_THE_FEET": "Abnormality of the epiphyses of the feet", "HP_ABNORMALITY_OF_THE_EXTRAOCULAR_MUSCLES": "Abnormality of the extraocular muscles", "HP_ABNORMALITY_OF_THE_ELBOW": "Abnormality of the elbow", "HP_ABNORMALITY_OF_THE_EXTRINSIC_PATHWAY": "Abnormality of the extrinsic pathway", "HP_ABNORMALITY_OF_THE_FIFTH_METATARSAL_BONE": "Abnormality of the fifth metatarsal bone", "HP_ABNORMALITY_OF_THE_FIRST_METATARSAL_BONE": "Abnormality of the first metatarsal bone", "HP_ABNORMALITY_OF_THE_FONTANELLES_OR_CRANIAL_SUTURES": "", "HP_ABNORMALITY_OF_THE_ENDOCRINE_SYSTEM": "Abnormality of the endocrine system", "HP_ABNORMALITY_OF_THE_FOREHEAD": "", "HP_ABNORMALITY_OF_THE_FOOT_MUSCULATURE": "Abnormality of the foot musculature", "HP_ABNORMALITY_OF_THE_FEMALE_GENITALIA": "Abnormality of the female genitalia", "HP_ABNORMALITY_OF_THE_GALLBLADDER": "Abnormality of the gallbladder", "HP_ABNORMALITY_OF_THE_GLABELLA": "Abnormality of the glabella", "HP_ABNORMALITY_OF_THE_FRONTAL_HAIRLINE": "Abnormality of the frontal hairline", "HP_ABNORMALITY_OF_THE_GLENOID_FOSSA": "Abnormality of the glenoid fossa", "HP_ABNORMALITY_OF_THE_GINGIVA": "Abnormality of the gingiva", "HP_ABNORMALITY_OF_THE_HAMATE_BONE": "", "HP_ABNORMALITY_OF_THE_HUMERUS": "", "HP_ABNORMALITY_OF_THE_HEPATIC_VASCULATURE": "Abnormality of the hepatic vasculature", "HP_ABNORMALITY_OF_THE_HUMERORADIAL_JOINT": "Abnormality of the humeroradial joint", "HP_ABNORMALITY_OF_THE_HYPOTHENAR_EMINENCE": "Abnormality of the hypothenar eminence", "HP_ABNORMALITY_OF_THE_INTERNAL_AUDITORY_CANAL": "Abnormality of the internal auditory canal", "HP_ABNORMALITY_OF_THE_INCISOR": "Abnormality of the incisor", "HP_ABNORMALITY_OF_THE_INNER_EAR": "Abnormality of the inner ear", "HP_ABNORMALITY_OF_THE_HYPOTHALAMUS_PITUITARY_AXIS": "Abnormality of the hypothalamus-pituitary axis", "HP_ABNORMALITY_OF_THE_INTRINSIC_PATHWAY": "Abnormality of the intrinsic pathway", "HP_ABNORMALITY_OF_THE_LEYDIG_CELLS": "Abnormality of the Leydig cells", "HP_ABNORMALITY_OF_THE_KNEE": "Abnormality of the knee", "HP_ABNORMALITY_OF_THE_LARYNX": "Abnormality of the larynx", "HP_ABNORMALITY_OF_THE_MENSTRUAL_CYCLE": "", "HP_ABNORMALITY_OF_THE_LOWER_URINARY_TRACT": "Abnormality of the lower urinary tract", "HP_ABNORMALITY_OF_THE_METOPIC_SUTURE": "Abnormality of the metopic suture", "HP_ABNORMALITY_OF_THE_MIDDLE_EAR_OSSICLES": "Abnormality of the middle ear ossicles", "HP_ABNORMALITY_OF_THE_LIVER": "Abnormality of the liver", "HP_ABNORMALITY_OF_THE_MIDDLE_PHALANX_OF_THE_2ND_FINGER": "Abnormality of the middle phalanx of the 2nd finger", "HP_ABNORMALITY_OF_THE_MIDDLE_PHALANGES_OF_THE_TOES": "Abnormality of the middle phalanges of the toes", "HP_ABNORMALITY_OF_THE_LYMPHATIC_SYSTEM": "Abnormality of the lymphatic system", "HP_ABNORMALITY_OF_THE_MALE_GENITALIA": "Abnormality of the male genitalia", "HP_ABNORMALITY_OF_THE_MIDDLE_EAR": "Abnormality of the middle ear", "HP_ABNORMALITY_OF_THE_MUSCULATURE_OF_THE_HAND": "Abnormality of the musculature of the hand", "HP_ABNORMALITY_OF_THE_MUSCULATURE_OF_THE_UPPER_ARM": "Abnormality of the musculature of the upper arm", "HP_ABNORMALITY_OF_THE_MUSCULATURE_OF_THE_LOWER_LIMBS": "Abnormality of the musculature of the lower limbs", "HP_ABNORMALITY_OF_THE_MITOCHONDRION": "Abnormality of the mitochondrion", "HP_ABNORMALITY_OF_THE_NAIL": "", "HP_ABNORMALITY_OF_THE_MUSCULATURE_OF_THE_UPPER_LIMBS": "Abnormality of the musculature of the upper limbs", "HP_ABNORMALITY_OF_THE_ORBITAL_REGION": "", "HP_ABNORMALITY_OF_THE_MUSCULATURE_OF_THE_LIMBS": "Abnormality of the musculature of the limbs", "HP_ABNORMALITY_OF_THE_PARATHYROID_GLAND": "Abnormality of the parathyroid gland", "HP_ABNORMALITY_OF_THE_NECK": "Abnormality of the neck", "HP_ABNORMALITY_OF_THE_OVARY": "Abnormality of the ovary", "HP_ABNORMALITY_OF_THE_OUTER_EAR": "Abnormality of the outer ear", "HP_ABNORMALITY_OF_THE_PANCREAS": "Abnormality of the pancreas", "HP_ABNORMALITY_OF_THE_PERIUNGUAL_REGION": "", "HP_ABNORMALITY_OF_THE_PHALANGES_OF_THE_2ND_FINGER": "Abnormality of the phalanges of the 2nd finger", "HP_ABNORMALITY_OF_THE_PERIORBITAL_REGION": "Abnormality of the periorbital region", "HP_ABNORMALITY_OF_THE_PALPEBRAL_FISSURES": "Abnormality of the palpebral fissures", "HP_ABNORMALITY_OF_THE_PHALANGES_OF_THE_3RD_TOE": "Abnormality of the phalanges of the 3rd toe", "HP_ABNORMALITY_OF_THE_PERIPHERAL_NERVOUS_SYSTEM": "Abnormality of the peripheral nervous system", "HP_ABNORMALITY_OF_THE_PINEAL_GLAND": "Abnormality of the pineal gland", "HP_ABNORMALITY_OF_THE_PREMAXILLA": "Abnormality of the premaxilla", "HP_ABNORMALITY_OF_THE_POSTERIOR_HAIRLINE": "Abnormality of the posterior hairline", "HP_ABNORMALITY_OF_THE_PROTEIN_C_ANTICOAGULANT_PATHWAY": "Abnormality of the protein C anticoagulant pathway", "HP_ABNORMALITY_OF_THE_PHARYNX": "Abnormality of the pharynx", "HP_ABNORMALITY_OF_THE_PLANTAR_SKIN_OF_FOOT": "Abnormality of the plantar skin of foot", "HP_ABNORMALITY_OF_THE_PROXIMAL_PHALANX_OF_THE_5TH_FINGER": "Abnormality of the proximal phalanx of the 5th finger", "HP_ABNORMALITY_OF_THE_PROXIMAL_PHALANX_OF_THE_THUMB": "Abnormality of the proximal phalanx of the thumb", "HP_ABNORMALITY_OF_THE_PHILTRUM": "Abnormality of the philtrum", "HP_ABNORMALITY_OF_THE_PUBIC_HAIR": "Abnormality of the pubic hair", "HP_ABNORMALITY_OF_THE_PULMONARY_ARTERY": "Abnormality of the pulmonary artery", "HP_ABNORMALITY_OF_THE_PYLORUS": "Abnormality of the pylorus", "HP_ABNORMALITY_OF_THE_PULMONARY_VASCULATURE": "Abnormality of the pulmonary vasculature", "HP_ABNORMALITY_OF_THE_RADIAL_HEAD": "Abnormality of the radial head", "HP_ABNORMALITY_OF_THE_SENSE_OF_SMELL": "Abnormality of the sense of smell", "HP_ABNORMALITY_OF_THE_SPINOCEREBELLAR_TRACTS": "", "HP_ABNORMALITY_OF_THE_STAPES": "", "HP_ABNORMALITY_OF_THE_SUBUNGUAL_REGION": "", "HP_ABNORMALITY_OF_THE_SHOULDER_GIRDLE_MUSCULATURE": "Abnormality of the shoulder girdle musculature", "HP_ABNORMALITY_OF_THE_SUPRAORBITAL_RIDGES": "Abnormality of the supraorbital ridges", "HP_ABNORMALITY_OF_THE_TEMPOROMANDIBULAR_JOINT": "Abnormality of the temporomandibular joint", "HP_ABNORMALITY_OF_THE_SPLEEN": "Abnormality of the spleen", "HP_ABNORMALITY_OF_THE_TARSAL_BONES": "Abnormality of the tarsal bones", "HP_ABNORMALITY_OF_THE_THENAR_EMINENCE": "Abnormality of the thenar eminence", "HP_ABNORMALITY_OF_THE_THORACIC_CAVITY": "Abnormality of the thoracic cavity", "HP_ABNORMALITY_OF_THE_TESTIS_SIZE": "Abnormality of the testis size", "HP_ABNORMALITY_OF_THE_TONGUE_MUSCLE": "Abnormality of the tongue muscle", "HP_ABNORMALITY_OF_THE_UPPER_ARM": "", "HP_ABNORMALITY_OF_THE_TONSILS": "Abnormality of the tonsils", "HP_ABNORMALITY_OF_THE_UMBILICAL_CORD": "Abnormality of the umbilical cord", "HP_ABNORMALITY_OF_THE_TONGUE": "Abnormality of the tongue", "HP_ABNORMALITY_OF_THE_THYROID_GLAND": "Abnormality of the thyroid gland", "HP_ABNORMALITY_OF_THE_UPPER_RESPIRATORY_TRACT": "Abnormality of the upper respiratory tract", "HP_ABNORMALITY_OF_THE_UPPER_URINARY_TRACT": "Abnormality of the upper urinary tract", "HP_ABNORMALITY_OF_THE_UPPER_LIMB": "Abnormality of the upper limb", "HP_ABNORMALITY_OF_THE_URETER": "Abnormality of the ureter", "HP_ABNORMALITY_OF_THE_URETHRA": "Abnormality of the urethra", "HP_ABNORMALITY_OF_THE_UTERUS": "Abnormality of the uterus", "HP_ABNORMALITY_OF_THE_VERTEBRAL_ENDPLATES": "Abnormality of the vertebral endplates", "HP_ABNORMALITY_OF_THE_VESTIBULOCOCHLEAR_NERVE": "", "HP_ABNORMALITY_OF_THE_VASCULATURE_OF_THE_EYE": "Abnormality of the vasculature of the eye", "HP_ABNORMALITY_OF_THE_URINARY_SYSTEM_PHYSIOLOGY": "Abnormality of the urinary system physiology", "HP_ABNORMALITY_OF_THE_VERTEBRAL_COLUMN": "Abnormality of the vertebral column", "HP_ABNORMALITY_OF_THROMBOCYTES": "", "HP_ABNORMALITY_OF_THE_WRIST": "Abnormality of the wrist", "HP_ABNORMALITY_OF_THUMB_PHALANX": "Abnormality of thumb phalanx", "HP_ABNORMALITY_OF_TIBIAL_EPIPHYSES": "Abnormality of tibial epiphyses", "HP_ABNORMALITY_OF_TUMOR_NECROSIS_FACTOR_SECRETION": "", "HP_ABNORMALITY_OF_T_CELL_PHYSIOLOGY": "", "HP_ABNORMALITY_OF_THE_VOICE": "Abnormality of the voice", "HP_ABNORMALITY_OF_URINARY_URIC_ACID_LEVEL": "Abnormality of urinary uric acid level", "HP_ABNORMALITY_OF_THYROID_PHYSIOLOGY": "Abnormality of thyroid physiology", "HP_ABNORMALITY_OF_VENOUS_PHYSIOLOGY": "Abnormality of venous physiology", "HP_ABNORMALITY_OF_UPPER_LIMB_JOINT": "Abnormality of upper limb joint", "HP_ABNORMALITY_OF_UPPER_LIP_VERMILLION": "Abnormality of upper lip vermillion", "HP_ABNORMALITY_OF_URINE_CALCIUM_CONCENTRATION": "Abnormality of urine calcium concentration", "HP_ABNORMALITY_OF_VISUAL_EVOKED_POTENTIALS": "Abnormality of visual evoked potentials", "HP_ABNORMALITY_OF_VITAMIN_B12_METABOLISM": "Abnormality of vitamin B12 metabolism", "HP_ABNORMALITY_OF_VITAMIN_B_METABOLISM": "Abnormality of vitamin B metabolism", "HP_ABNORMALITY_OF_VITAMIN_K_METABOLISM": "Abnormality of vitamin K metabolism", "HP_ABNORMALITY_OF_VITAMIN_D_METABOLISM": "Abnormality of vitamin D metabolism", "HP_ABNORMALITY_OF_URINE_HOMEOSTASIS": "Abnormality of urine homeostasis", "HP_ABNORMALITY_OF_VON_WILLEBRAND_FACTOR": "Abnormality of von Willebrand factor", "HP_ABNORMALITY_THIGH_MUSCULATURE_MORPHOLOGY": "Abnormality thigh musculature morphology", "HP_ABNORMALITY_OF_VISION": "Abnormality of vision", "HP_ABNORMALITY_OF_VITAMIN_METABOLISM": "Abnormality of vitamin metabolism", "HP_ABNORMALITY_ON_PULMONARY_FUNCTION_TESTING": "Abnormality on pulmonary function testing", "HP_ABNORMALLY_LOW_PITCHED_VOICE": "Abnormally low-pitched voice", "HP_ABNORMALLY_LARGE_GLOBE": "Abnormally large globe", "HP_ABNORMALLY_FOLDED_HELIX": "Abnormally folded helix", "HP_ABNORMALLY_LOW_T_CELL_RECEPTOR_EXCISION_CIRCLE_LEVEL": "Abnormally low T cell receptor excision circle level", "HP_ABNORMALLY_OSSIFIED_VERTEBRAE": "Abnormally ossified vertebrae", "HP_ABNORMALLY_LAX_OR_HYPEREXTENSIBLE_SKIN": "Abnormally lax or hyperextensible skin", "HP_ABNORMALLY_SHAPED_CARPAL_BONES": "Abnormally shaped carpal bones", "HP_ABNORMAL_2ND_METACARPAL_MORPHOLOGY": "Abnormal 2nd metacarpal morphology", "HP_ABNORMAL_1ST_METACARPAL_MORPHOLOGY": "Abnormal 1st metacarpal morphology", "HP_ABNORMAL_2ND_FINGER_MORPHOLOGY": "Abnormal 2nd finger morphology", "HP_ABNORMAL_3RD_FINGER_PHALANX_MORPHOLOGY": "Abnormal 3rd finger phalanx morphology", "HP_ABNORMAL_3RD_FINGER_MORPHOLOGY": "Abnormal 3rd finger morphology", "HP_ABNORMAL_4TH_FINGER_MORPHOLOGY": "Abnormal 4th finger morphology", "HP_ABNORMAL_4TH_METACARPAL_MORPHOLOGY": "Abnormal 4th metacarpal morphology", "HP_ABNORMAL_5TH_FINGER_PHALANX_MORPHOLOGY": "Abnormal 5th finger phalanx morphology", "HP_ABNORMAL_5TH_METACARPAL_MORPHOLOGY": "Abnormal 5th metacarpal morphology", "HP_ABNORMAL_5TH_FINGER_MORPHOLOGY": "Abnormal 5th finger morphology", "HP_ABNORMAL_ACETABULUM_MORPHOLOGY": "Abnormal acetabulum morphology", "HP_ABNORMAL_ALPHA_GRANULES": "Abnormal alpha granules", "HP_ABNORMAL_ACTIVITY_OF_MITOCHONDRIAL_RESPIRATORY_CHAIN": "Abnormal activity of mitochondrial respiratory chain", "HP_ABNORMAL_ALVEOLAR_RIDGE_MORPHOLOGY": "Abnormal alveolar ridge morphology", "HP_ABNORMAL_ABDOMEN_MORPHOLOGY": "Abnormal abdomen morphology", "HP_ABNORMAL_AMPLITUDE_OF_DARK_ADAPTED_BRIGHT_FLASH_ELECTRORETINOGRAM": "Abnormal amplitude of dark-adapted bright flash electroretinogram", "HP_ABNORMAL_ADIPOSE_TISSUE_MORPHOLOGY": "Abnormal adipose tissue morphology", "HP_ABNORMAL_AMPLITUDE_OF_PATTERN_ELECTRORETINOGRAM": "", "HP_ABNORMAL_AFFECT": "Abnormal affect", "HP_ABNORMAL_ANKLE_MORPHOLOGY": "Abnormal ankle morphology", "HP_ABNORMAL_ANKLE_PHYSIOLOGY": "Abnormal ankle physiology", "HP_ABNORMAL_ANATOMIC_LOCATION_OF_THE_HEART": "Abnormal anatomic location of the heart", "HP_ABNORMAL_ANTERIOR_CHAMBER_MORPHOLOGY": "Abnormal anterior chamber morphology", "HP_ABNORMAL_ANTITRAGUS_MORPHOLOGY": "Abnormal antitragus morphology", "HP_ABNORMAL_ANTERIOR_HORN_CELL_MORPHOLOGY": "", "HP_ABNORMAL_ANTIHELIX_MORPHOLOGY": "Abnormal antihelix morphology", "HP_ABNORMAL_AORTIC_ARCH_MORPHOLOGY": "Abnormal aortic arch morphology", "HP_ABNORMAL_AORTIC_VALVE_CUSP_MORPHOLOGY": "Abnormal aortic valve cusp morphology", "HP_ABNORMAL_AORTIC_MORPHOLOGY": "Abnormal aortic morphology", "HP_ABNORMAL_ARACHNOID_MATER_MORPHOLOGY": "Abnormal arachnoid mater morphology", "HP_ABNORMAL_ARM_SPAN": "Abnormal arm span", "HP_ABNORMAL_AORTIC_VALVE_MORPHOLOGY": "Abnormal aortic valve morphology", "HP_ABNORMAL_AORTIC_VALVE_PHYSIOLOGY": "Abnormal aortic valve physiology", "HP_ABNORMAL_ANTERIOR_EYE_SEGMENT_MORPHOLOGY": "Abnormal anterior eye segment morphology", "HP_ABNORMAL_ASCENDING_AORTA_MORPHOLOGY": "Abnormal ascending aorta morphology", "HP_ABNORMAL_ARTERIAL_PHYSIOLOGY": "Abnormal arterial physiology", "HP_ABNORMAL_ASTROCYTE_MORPHOLOGY": "Abnormal astrocyte morphology", "HP_ABNORMAL_ATRIOVENTRICULAR_CONNECTION": "Abnormal atrioventricular connection", "HP_ABNORMAL_ATRIAL_ARRANGEMENT": "Abnormal atrial arrangement", "HP_ABNORMAL_ATRIOVENTRICULAR_CONDUCTION": "Abnormal atrioventricular conduction", "HP_ABNORMAL_AUDITORY_EVOKED_POTENTIALS": "Abnormal auditory evoked potentials", "HP_ABNORMAL_AUDITORY_CANAL_MORPHOLOGY": "Abnormal auditory canal morphology", "HP_ABNORMAL_ATRIOVENTRICULAR_VALVE_MORPHOLOGY": "Abnormal atrioventricular valve morphology", "HP_ABNORMAL_BASAL_GANGLIA_MRI_SIGNAL_INTENSITY": "Abnormal basal ganglia MRI signal intensity", "HP_ABNORMAL_ATRIOVENTRICULAR_VALVE_PHYSIOLOGY": "Abnormal atrioventricular valve physiology", "HP_ABNORMAL_AUTONOMIC_NERVOUS_SYSTEM_PHYSIOLOGY": "Abnormal autonomic nervous system physiology", "HP_ABNORMAL_BASOPHIL_COUNT": "", "HP_ABNORMAL_BASOPHIL_MORPHOLOGY": "Abnormal basophil morphology", "HP_ABNORMAL_BASAL_GANGLIA_MORPHOLOGY": "Abnormal basal ganglia morphology", "HP_ABNORMAL_BLADDER_MORPHOLOGY": "Abnormal bladder morphology", "HP_ABNORMAL_BLOOD_CHLORIDE_CONCENTRATION": "Abnormal blood chloride concentration", "HP_ABNORMAL_BLISTERING_OF_THE_SKIN": "Abnormal blistering of the skin", "HP_ABNORMAL_BLOOD_FOLATE_CONCENTRATION": "Abnormal blood folate concentration", "HP_ABNORMAL_BLOOD_GAS_LEVEL": "Abnormal blood gas level", "HP_ABNORMAL_BLEEDING": "Abnormal bleeding", "HP_ABNORMAL_BLOOD_INORGANIC_CATION_CONCENTRATION": "Abnormal blood inorganic cation concentration", "HP_ABNORMAL_BLOOD_GLUCOSE_CONCENTRATION": "Abnormal blood glucose concentration", "HP_ABNORMAL_BLOOD_POTASSIUM_CONCENTRATION": "", "HP_ABNORMAL_BLOOD_MONOVALENT_INORGANIC_CATION_CONCENTRATION": "Abnormal blood monovalent inorganic cation concentration", "HP_ABNORMAL_BLOOD_PHOSPHATE_CONCENTRATION": "Abnormal blood phosphate concentration", "HP_ABNORMAL_BLOOD_ION_CONCENTRATION": "Abnormal blood ion concentration", "HP_ABNORMAL_BLOOD_TRANSITION_ELEMENT_CATION_CONCENTRATION": "Abnormal blood transition element cation concentration", "HP_ABNORMAL_BLOOD_SODIUM_CONCENTRATION": "Abnormal blood sodium concentration", "HP_ABNORMAL_BLOOD_UREA_NITROGEN_CONCENTRATION": "Abnormal blood urea nitrogen concentration", "HP_ABNORMAL_BLOOD_ZINC_CONCENTRATION": "Abnormal blood zinc concentration", "HP_ABNORMAL_BOWEL_SOUNDS": "Abnormal bowel sounds", "HP_ABNORMAL_BLOOD_VESSEL_MORPHOLOGY": "Abnormal blood vessel morphology", "HP_ABNORMAL_BOWMAN_CAPSULE_MORPHOLOGY": "Abnormal Bowman capsule morphology", "HP_ABNORMAL_BONE_MARROW_CELL_MORPHOLOGY": "Abnormal bone marrow cell morphology", "HP_ABNORMAL_BRAINSTEM_WHITE_MATTER_MORPHOLOGY": "Abnormal brainstem white matter morphology", "HP_ABNORMAL_BRAINSTEM_MORPHOLOGY": "Abnormal brainstem morphology", "HP_ABNORMAL_BRAIN_EVOKED_POTENTIALS": "Abnormal brain-evoked potentials", "HP_ABNORMAL_BRAINSTEM_MRI_SIGNAL_INTENSITY": "Abnormal brainstem MRI signal intensity", "HP_ABNORMAL_BRAIN_FDG_POSITRON_EMISSION_TOMOGRAPHY": "Abnormal brain FDG positron emission tomography", "HP_ABNORMAL_BONE_STRUCTURE": "Abnormal bone structure", "HP_ABNORMAL_BRAIN_LACTATE_LEVEL_BY_MRS": "Abnormal brain lactate level by MRS", "HP_ABNORMAL_BRAIN_N_ACETYL_ASPARTATE_LEVEL_BY_MRS": "Abnormal brain N-acetyl aspartate level by MRS", "HP_ABNORMAL_BRONCHOALVEOLAR_LAVAGE_FLUID_MORPHOLOGY": "Abnormal bronchoalveolar lavage fluid morphology", "HP_ABNORMAL_BRANCHING_PATTERN_OF_THE_AORTIC_ARCH": "Abnormal branching pattern of the aortic arch", "HP_ABNORMAL_BREATH_SOUND": "Abnormal breath sound", "HP_ABNORMAL_BRONCHUS_PHYSIOLOGY": "Abnormal bronchus physiology", "HP_ABNORMAL_CALCIFICATION_OF_THE_CARPAL_BONES": "Abnormal calcification of the carpal bones", "HP_ABNORMAL_BRONCHUS_MORPHOLOGY": "Abnormal bronchus morphology", "HP_ABNORMAL_B_CELL_MORPHOLOGY": "Abnormal B cell morphology", "HP_ABNORMAL_B_CELL_SUBSET_DISTRIBUTION": "Abnormal B cell subset distribution", "HP_ABNORMAL_CALF_MUSCULATURE_MORPHOLOGY": "Abnormal calf musculature morphology", "HP_ABNORMAL_CAPILLARY_PHYSIOLOGY": "Abnormal capillary physiology", "HP_ABNORMAL_CARDIAC_BIOMARKER_TEST": "Abnormal cardiac biomarker test", "HP_ABNORMAL_CARDIAC_EXERCISE_STRESS_TEST": "Abnormal cardiac exercise stress test", "HP_ABNORMAL_CARDIAC_TEST": "Abnormal cardiac test", "HP_ABNORMAL_CARDIAC_ATRIUM_MORPHOLOGY": "Abnormal cardiac atrium morphology", "HP_ABNORMAL_CARDIAC_VENTRICULAR_FUNCTION": "Abnormal cardiac ventricular function", "HP_ABNORMAL_CALVARIA_MORPHOLOGY": "Abnormal calvaria morphology", "HP_ABNORMAL_CAROTID_ARTERY_MORPHOLOGY": "Abnormal carotid artery morphology", "HP_ABNORMAL_CARDIOMYOCYTE_MORPHOLOGY": "Abnormal cardiomyocyte morphology", "HP_ABNORMAL_CARDIAC_SEPTUM_MORPHOLOGY": "Abnormal cardiac septum morphology", "HP_ABNORMAL_CARDIAC_VENTRICLE_MORPHOLOGY": "Abnormal cardiac ventricle morphology", "HP_ABNORMAL_CARPAL_MORPHOLOGY": "Abnormal carpal morphology", "HP_ABNORMAL_CARDIOVASCULAR_SYSTEM_PHYSIOLOGY": "Abnormal cardiovascular system physiology", "HP_ABNORMAL_CAUDATE_NUCLEUS_MORPHOLOGY": "Abnormal caudate nucleus morphology", "HP_ABNORMAL_CARTILAGE_MORPHOLOGY": "Abnormal cartilage morphology", "HP_ABNORMAL_CD4_CD8_RATIO": "Abnormal CD4:CD8 ratio", "HP_ABNORMAL_CELLULAR_COMPOSITION_OF_BRONCHOALVEOLAR_FLUID": "Abnormal cellular composition of bronchoalveolar fluid", "HP_ABNORMAL_CELL_MORPHOLOGY": "Abnormal cell morphology", "HP_ABNORMAL_CENTRAL_SENSORY_FUNCTION": "Abnormal central sensory function", "HP_ABNORMAL_CEREBELLAR_CORTEX_MORPHOLOGY": "Abnormal cerebellar cortex morphology", "HP_ABNORMAL_CEREBRAL_ARTERY_MORPHOLOGY": "Abnormal cerebral artery morphology", "HP_ABNORMAL_CELLULAR_PHENOTYPE": "Abnormal cellular phenotype", "HP_ABNORMAL_CEREBRAL_VEIN_MORPHOLOGY": "Abnormal cerebral vein morphology", "HP_ABNORMAL_CEREBELLAR_VERMIS_MORPHOLOGY": "Abnormal cerebellar vermis morphology", "HP_ABNORMAL_CEREBRAL_VASCULAR_MORPHOLOGY": "Abnormal cerebral vascular morphology", "HP_ABNORMAL_CERVICAL_CURVATURE": "Abnormal cervical curvature", "HP_ABNORMAL_CERVICAL_SPINE_MORPHOLOGY": "Abnormal cervical spine morphology", "HP_ABNORMAL_CEREBRAL_CORTEX_MORPHOLOGY": "Abnormal cerebral cortex morphology", "HP_ABNORMAL_CEREBRAL_SUBCORTEX_MORPHOLOGY": "Abnormal cerebral subcortex morphology", "HP_ABNORMAL_CEREBROSPINAL_FLUID_MORPHOLOGY": "Abnormal cerebrospinal fluid morphology", "HP_ABNORMAL_CEREBRAL_VENTRICLE_MORPHOLOGY": "Abnormal cerebral ventricle morphology", "HP_ABNORMAL_CHORIORETINAL_MORPHOLOGY": "Abnormal chorioretinal morphology", "HP_ABNORMAL_CHEEK_MORPHOLOGY": "Abnormal cheek morphology", "HP_ABNORMAL_CHOROID_PLEXUS_MORPHOLOGY": "Abnormal choroid plexus morphology", "HP_ABNORMAL_CHOROID_MORPHOLOGY": "Abnormal choroid morphology", "HP_ABNORMAL_CILIARY_BODY_MORPHOLOGY": "Abnormal ciliary body morphology", "HP_ABNORMAL_CIRCLE_OF_WILLIS_MORPHOLOGY": "Abnormal circle of Willis morphology", "HP_ABNORMAL_CIRCULATING_ACYLCARNITINE_CONCENTRATION": "Abnormal circulating acylcarnitine concentration", "HP_ABNORMAL_CIRCULATING_ADRENOCORTICOTROPIN_CONCENTRATION": "Abnormal circulating adrenocorticotropin concentration", "HP_ABNORMAL_CIRCULATING_ALBUMIN_CONCENTRATION": "Abnormal circulating albumin concentration", "HP_ABNORMAL_CIRCULATING_ALDOLASE_CONCENTRATION": "Abnormal circulating aldolase concentration", "HP_ABNORMAL_CIRCULATING_ALDOSTERONE": "", "HP_ABNORMAL_CIRCULATING_AMYLASE_CONCENTRATION": "Abnormal circulating amylase concentration", "HP_ABNORMAL_CIRCULATING_ALPHA_FETOPROTEIN_CONCENTRATION": "Abnormal circulating alpha-fetoprotein concentration", "HP_ABNORMAL_CIRCULATING_ANDROSTENEDIONE_CONCENTRATION": "Abnormal circulating androstenedione concentration", "HP_ABNORMAL_CIRCULATING_ANDROGEN_LEVEL": "Abnormal circulating androgen level", "HP_ABNORMAL_CIRCULATING_ANTIMULLERIAN_HORMONE_CONCENTRATION": "Abnormal circulating antimullerian hormone concentration", "HP_ABNORMAL_CIRCULATING_AMINO_ACID_CONCENTRATION": "Abnormal circulating amino acid concentration", "HP_ABNORMAL_CIRCULATING_APOLIPOPROTEIN_CONCENTRATION": "Abnormal circulating apolipoprotein concentration", "HP_ABNORMAL_CIRCULATING_ARGININE_CONCENTRATION": "Abnormal circulating arginine concentration", "HP_ABNORMAL_CIRCULATING_AROMATIC_AMINO_ACID_CONCENTRATION": "Abnormal circulating aromatic amino acid concentration", "HP_ABNORMAL_CIRCULATING_ASPARTATE_FAMILY_AMINO_ACID_CONCENTRATION": "Abnormal circulating aspartate family amino acid concentration", "HP_ABNORMAL_CIRCULATING_ATRIAL_NATRIURETIC_PEPTIDE_PRO_HORMONE_CONCENTRATION": "", "HP_ABNORMAL_CIRCULATING_BETA_GLOBULIN_LEVEL": "", "HP_ABNORMAL_CIRCULATING_CARBOHYDRATE_CONCENTRATION": "Abnormal circulating carbohydrate concentration", "HP_ABNORMAL_CIRCULATING_BRANCHED_CHAIN_AMINO_ACID_CONCENTRATION": "Abnormal circulating branched chain amino acid concentration", "HP_ABNORMAL_CIRCULATING_CALCIUM_PHOSPHATE_REGULATING_HORMONE_CONCENTRATION": "Abnormal circulating calcium-phosphate regulating hormone concentration", "HP_ABNORMAL_CIRCULATING_BILIRUBIN_CONCENTRATION": "Abnormal circulating bilirubin concentration", "HP_ABNORMAL_CIRCULATING_CERULOPLASMIN_CONCENTRATION": "Abnormal circulating ceruloplasmin concentration", "HP_ABNORMAL_CIRCULATING_CREATINE_CONCENTRATION": "Abnormal circulating creatine concentration", "HP_ABNORMAL_CIRCULATING_COPPER_CONCENTRATION": "Abnormal circulating copper concentration", "HP_ABNORMAL_CIRCULATING_CITRULLINE_CONCENTRATION": "Abnormal circulating citrulline concentration", "HP_ABNORMAL_CIRCULATING_CHOLESTEROL_CONCENTRATION": "Abnormal circulating cholesterol concentration", "HP_ABNORMAL_CIRCULATING_CARBOXYLIC_ACID_CONCENTRATION": "Abnormal circulating carboxylic acid concentration", "HP_ABNORMAL_CIRCULATING_CREATININE_CONCENTRATION": "Abnormal circulating creatinine concentration", "HP_ABNORMAL_CIRCULATING_DEHYDROEPIANDROSTERONE_CONCENTRATION": "Abnormal circulating dehydroepiandrosterone concentration", "HP_ABNORMAL_CIRCULATING_C_PEPTIDE_CONCENTRATION": "Abnormal circulating C-peptide concentration", "HP_ABNORMAL_CIRCULATING_DICARBOXYLIC_ACID_CONCENTRATION": "Abnormal circulating dicarboxylic acid concentration", "HP_ABNORMAL_CIRCULATING_C_REACTIVE_PROTEIN_CONCENTRATION": "Abnormal circulating C-reactive protein concentration", "HP_ABNORMAL_CIRCULATING_FATTY_ACID_CONCENTRATION": "Abnormal circulating fatty-acid concentration", "HP_ABNORMAL_CIRCULATING_FREE_FATTY_ACID_CONCENTRATION": "Abnormal circulating free fatty acid concentration", "HP_ABNORMAL_CIRCULATING_FERRITIN_CONCENTRATION": "Abnormal circulating ferritin concentration", "HP_ABNORMAL_CIRCULATING_FATTY_ACID_ANION_CONCENTRATION": "Abnormal circulating fatty-acid anion concentration", "HP_ABNORMAL_CIRCULATING_FOLLICLE_STIMULATING_HORMONE_CONCENTRATION": "Abnormal circulating follicle-stimulating hormone concentration", "HP_ABNORMAL_CIRCULATING_FREE_T3_CONCENTRATION": "Abnormal circulating free T3 concentration", "HP_ABNORMAL_CIRCULATING_GABA_CONCENTRATION": "Abnormal circulating GABA concentration", "HP_ABNORMAL_CIRCULATING_FREE_T4_CONCENTRATION": "Abnormal circulating free T4 concentration", "HP_ABNORMAL_CIRCULATING_GLOBULIN_CONCENTRATION": "Abnormal circulating globulin concentration", "HP_ABNORMAL_CIRCULATING_GLUTAMINE_CONCENTRATION": "Abnormal circulating glutamine concentration", "HP_ABNORMAL_CIRCULATING_GLYCINE_CONCENTRATION": "Abnormal circulating glycine concentration", "HP_ABNORMAL_CIRCULATING_GLUTAMINE_FAMILY_AMINO_ACID_CONCENTRATION": "Abnormal circulating glutamine family amino acid concentration", "HP_ABNORMAL_CIRCULATING_HAPTOGLOBIN_CONCENTRATION": "Abnormal circulating haptoglobin concentration", "HP_ABNORMAL_CIRCULATING_HOMOCYSTEINE_CONCENTRATION": "Abnormal circulating homocysteine concentration", "HP_ABNORMAL_CIRCULATING_GONADOTROPIN_CONCENTRATION": "Abnormal circulating gonadotropin concentration", "HP_ABNORMAL_CIRCULATING_IGE_LEVEL": "", "HP_ABNORMAL_CIRCULATING_IGA_LEVEL": "", "HP_ABNORMAL_CIRCULATING_IGM_LEVEL": "", "HP_ABNORMAL_CIRCULATING_IGG_LEVEL": "", "HP_ABNORMAL_CIRCULATING_HORMONE_CONCENTRATION": "Abnormal circulating hormone concentration", "HP_ABNORMAL_CIRCULATING_INHIBIN_B_CONCENTRATION": "", "HP_ABNORMAL_CIRCULATING_INTERFERON_CONCENTRATION": "Abnormal circulating interferon concentration", "HP_ABNORMAL_CIRCULATING_INTERLEUKIN_10_CONCENTRATION": "Abnormal circulating interleukin 10 concentration", "HP_ABNORMAL_CIRCULATING_INSULIN_CONCENTRATION": "Abnormal circulating insulin concentration", "HP_ABNORMAL_CIRCULATING_INTERLEUKIN_CONCENTRATION": "Abnormal circulating interleukin concentration", "HP_ABNORMAL_CIRCULATING_LEUCINE_CONCENTRATION": "Abnormal circulating leucine concentration", "HP_ABNORMAL_CIRCULATING_LACTATE_DEHYDROGENASE_CONCENTRATION": "Abnormal circulating lactate dehydrogenase concentration", "HP_ABNORMAL_CIRCULATING_LEPTIN_CONCENTRATION": "Abnormal circulating leptin concentration", "HP_ABNORMAL_CIRCULATING_IRON_CONCENTRATION": "Abnormal circulating iron concentration", "HP_ABNORMAL_CIRCULATING_LYSINE_CONCENTRATION": "Abnormal circulating lysine concentration", "HP_ABNORMAL_CIRCULATING_LONG_CHAIN_FATTY_ACID_CONCENTRATION": "Abnormal circulating long-chain fatty-acid concentration", "HP_ABNORMAL_CIRCULATING_METHIONINE_CONCENTRATION": "Abnormal circulating methionine concentration", "HP_ABNORMAL_CIRCULATING_MONOCARBOXYLIC_ACID_CONCENTRATION": "Abnormal circulating monocarboxylic acid concentration", "HP_ABNORMAL_CIRCULATING_LIPID_CONCENTRATION": "Abnormal circulating lipid concentration", "HP_ABNORMAL_CIRCULATING_NITROGEN_COMPOUND_CONCENTRATION": "Abnormal circulating nitrogen compound concentration", "HP_ABNORMAL_CIRCULATING_OSTEOCALCIN_LEVEL": "Abnormal circulating osteocalcin level", "HP_ABNORMAL_CIRCULATING_ORNITHINE_CONCENTRATION": "Abnormal circulating ornithine concentration", "HP_ABNORMAL_CIRCULATING_NON_PROTEINOGENIC_AMINO_ACID_CONCENTRATION": "Abnormal circulating non-proteinogenic amino acid concentration", "HP_ABNORMAL_CIRCULATING_PHENYLALANINE_CONCENTRATION": "Abnormal circulating phenylalanine concentration", "HP_ABNORMAL_CIRCULATING_METABOLITE_CONCENTRATION": "Abnormal circulating metabolite concentration", "HP_ABNORMAL_CIRCULATING_NUCLEOBASE_CONCENTRATION": "Abnormal circulating nucleobase concentration", "HP_ABNORMAL_CIRCULATING_PORPHYRIN_CONCENTRATION": "Abnormal circulating porphyrin concentration", "HP_ABNORMAL_CIRCULATING_PROGESTERONE_LEVEL": "Abnormal circulating progesterone level", "HP_ABNORMAL_CIRCULATING_ORGANIC_COMPOUND_CONCENTRATION": "Abnormal circulating organic compound concentration", "HP_ABNORMAL_CIRCULATING_PROLINE_CONCENTRATION": "Abnormal circulating proline concentration", "HP_ABNORMAL_CIRCULATING_PROTEINOGENIC_AMINO_ACID_CONCENTRATION": "Abnormal circulating proteinogenic amino acid concentration", "HP_ABNORMAL_CIRCULATING_PROTEINOGENIC_AMINO_ACID_DERIVATIVE_CONCENTRATION": "Abnormal circulating proteinogenic amino acid derivative concentration", "HP_ABNORMAL_CIRCULATING_SERINE_CONCENTRATION": "Abnormal circulating serine concentration", "HP_ABNORMAL_CIRCULATING_RENIN": "", "HP_ABNORMAL_CIRCULATING_SERINE_FAMILY_AMINO_ACID_CONCENTRATION": "Abnormal circulating serine family amino acid concentration", "HP_ABNORMAL_CIRCULATING_SULFUR_AMINO_ACID_CONCENTRATION": "Abnormal circulating sulfur amino acid concentration", "HP_ABNORMAL_CIRCULATING_SEX_HORMONE_CONCENTRATION": "Abnormal circulating sex hormone concentration", "HP_ABNORMAL_CIRCULATING_T4_CONCENTRATION": "Abnormal circulating T4 concentration", "HP_ABNORMAL_CIRCULATING_PROTEIN_CONCENTRATION": "Abnormal circulating protein concentration", "HP_ABNORMAL_CIRCULATING_THYROGLOBULIN_CONCENTRATION": "Abnormal circulating thyroglobulin concentration", "HP_ABNORMAL_CIRCULATING_VITAMIN_B12_CONCENTRATION": "Abnormal circulating vitamin B12 concentration", "HP_ABNORMAL_CIRCULATING_THYROID_HORMONE_CONCENTRATION": "Abnormal circulating thyroid hormone concentration", "HP_ABNORMAL_CIRCULATING_VITAMIN_A_CONCENTRATION": "Abnormal circulating vitamin A concentration", "HP_ABNORMAL_CIRCULATING_VITAMIN_E_CONCENTRATION": "Abnormal circulating vitamin E concentration", "HP_ABNORMAL_CLAVICLE_MORPHOLOGY": "Abnormal clavicle morphology", "HP_ABNORMAL_COAGULATION_FACTOR_V_ACTIVITY": "Abnormal coagulation factor V activity", "HP_ABNORMAL_COCCYX_MORPHOLOGY": "Abnormal coccyx morphology", "HP_ABNORMAL_COCHLEA_MORPHOLOGY": "Abnormal cochlea morphology", "HP_ABNORMAL_CLITORIS_MORPHOLOGY": "Abnormal clitoris morphology", "HP_ABNORMAL_CNS_MYELINATION": "Abnormal CNS myelination", "HP_ABNORMAL_COLUMELLA_MORPHOLOGY": "Abnormal columella morphology", "HP_ABNORMAL_CORNEAL_ENDOTHELIUM_MORPHOLOGY": "Abnormal corneal endothelium morphology", "HP_ABNORMAL_CONUS_TERMINALIS_MORPHOLOGY": "Abnormal conus terminalis morphology", "HP_ABNORMAL_CONNECTION_OF_THE_CARDIAC_SEGMENTS": "Abnormal connection of the cardiac segments", "HP_ABNORMAL_CONSUMPTION_BEHAVIOR": "Abnormal consumption behavior", "HP_ABNORMAL_CONJUNCTIVA_MORPHOLOGY": "Abnormal conjunctiva morphology", "HP_ABNORMAL_CORNEAL_REFLEX": "Abnormal corneal reflex", "HP_ABNORMAL_CORNEAL_EPITHELIUM_MORPHOLOGY": "Abnormal corneal epithelium morphology", "HP_ABNORMAL_CONJUGATE_EYE_MOVEMENT": "Abnormal conjugate eye movement", "HP_ABNORMAL_CORNEAL_STROMA_MORPHOLOGY": "Abnormal corneal stroma morphology", "HP_ABNORMAL_CORONARY_ARTERY_ORIGIN": "Abnormal coronary artery origin", "HP_ABNORMAL_CORONARY_ARTERY_MORPHOLOGY": "Abnormal coronary artery morphology", "HP_ABNORMAL_CORTICAL_BONE_MORPHOLOGY": "Abnormal cortical bone morphology", "HP_ABNORMAL_CORNEA_MORPHOLOGY": "Abnormal cornea morphology", "HP_ABNORMAL_CORTICOSPINAL_TRACT_MORPHOLOGY": "Abnormal corticospinal tract morphology", "HP_ABNORMAL_CORPUS_STRIATUM_MORPHOLOGY": "Abnormal corpus striatum morphology", "HP_ABNORMAL_CRANIAL_NERVE_MORPHOLOGY": "Abnormal cranial nerve morphology", "HP_ABNORMAL_CRY": "Abnormal cry", "HP_ABNORMAL_CSF_CARBOXYLIC_ACID_CONCENTRATION": "Abnormal CSF carboxylic acid concentration", "HP_ABNORMAL_CORTICAL_GYRATION": "Abnormal cortical gyration", "HP_ABNORMAL_CSF_GLUCOSE_CONCENTRATION": "Abnormal CSF glucose concentration", "HP_ABNORMAL_CSF_GLYCINE_CONCENTRATION": "Abnormal CSF glycine concentration", "HP_ABNORMAL_CSF_HOMOVANILLIC_ACID_CONCENTRATION": "Abnormal CSF homovanillic acid concentration", "HP_ABNORMAL_CSF_PYRUVATE_FAMILY_AMINO_ACID_CONCENTRATION": "Abnormal CSF pyruvate family amino acid concentration", "HP_ABNORMAL_CSF_LACTATE_CONCENTRATION": "Abnormal CSF lactate concentration", "HP_ABNORMAL_CSF_PROTEIN_CONCENTRATION": "Abnormal CSF protein concentration", "HP_ABNORMAL_CSF_METABOLITE_CONCENTRATION": "Abnormal CSF metabolite concentration", "HP_ABNORMAL_DELAYED_HYPERSENSITIVITY_SKIN_TEST": "Abnormal delayed hypersensitivity skin test", "HP_ABNORMAL_DENSE_GRANULES": "Abnormal dense granules", "HP_ABNORMAL_DELIVERY": "Abnormal delivery", "HP_ABNORMAL_DENTAL_PULP_MORPHOLOGY": "Abnormal dental pulp morphology", "HP_ABNORMAL_DENTATE_NUCLEUS_MORPHOLOGY": "Abnormal dentate nucleus morphology", "HP_ABNORMAL_DENTIN_MORPHOLOGY": "Abnormal dentin morphology", "HP_ABNORMAL_DENTAL_MORPHOLOGY": "Abnormal dental morphology", "HP_ABNORMAL_CURVATURE_OF_THE_VERTEBRAL_COLUMN": "Abnormal curvature of the vertebral column", "HP_ABNORMAL_DERMOEPIDERMAL_JUNCTION_MORPHOLOGY": "Abnormal dermoepidermal junction morphology", "HP_ABNORMAL_DENTAL_ROOT_MORPHOLOGY": "Abnormal dental root morphology", "HP_ABNORMAL_DESCEMET_MEMBRANE_MORPHOLOGY": "Abnormal Descemet membrane morphology", "HP_ABNORMAL_DERMATOGLYPHICS": "Abnormal dermatoglyphics", "HP_ABNORMAL_DISTAL_FEMORAL_METAPHYSIS_MORPHOLOGY": "Abnormal distal femoral metaphysis morphology", "HP_ABNORMAL_DIAPHYSIS_MORPHOLOGY": "Abnormal diaphysis morphology", "HP_ABNORMAL_DURA_MATER_MORPHOLOGY": "Abnormal dura mater morphology", "HP_ABNORMAL_DIGESTIVE_SYSTEM_MORPHOLOGY": "Abnormal digestive system morphology", "HP_ABNORMAL_DUODENUM_MORPHOLOGY": "Abnormal duodenum morphology", "HP_ABNORMAL_DISTAL_PHALANX_MORPHOLOGY_OF_FINGER": "Abnormal distal phalanx morphology of finger", "HP_ABNORMAL_DRINKING_BEHAVIOR": "Abnormal drinking behavior", "HP_ABNORMAL_EARLOBE_MORPHOLOGY": "Abnormal earlobe morphology", "HP_ABNORMAL_EATING_BEHAVIOR": "Abnormal eating behavior", "HP_ABNORMAL_EKG": "Abnormal EKG", "HP_ABNORMAL_ELASTICITY_OF_SKIN": "Abnormal elasticity of skin", "HP_ABNORMAL_ELECTROPHYSIOLOGY_OF_SINOATRIAL_NODE_ORIGIN": "Abnormal electrophysiology of sinoatrial node origin", "HP_ABNORMAL_EAR_MORPHOLOGY": "Abnormal ear morphology", "HP_ABNORMAL_ENDOCRINE_MORPHOLOGY": "", "HP_ABNORMAL_EMOTION": "", "HP_ABNORMAL_ELECTRORETINOGRAM": "Abnormal electroretinogram", "HP_ABNORMAL_ENDOMETRIUM_MORPHOLOGY": "Abnormal endometrium morphology", "HP_ABNORMAL_ENDOCARDIUM_MORPHOLOGY": "Abnormal endocardium morphology", "HP_ABNORMAL_ENCHONDRAL_OSSIFICATION": "Abnormal enchondral ossification", "HP_ABNORMAL_ENERGY_EXPENDITURE": "Abnormal energy expenditure", "HP_ABNORMAL_ENZYME_ACTIVITY_IN_MUSCLE_TISSUE": "Abnormal enzyme activity in muscle tissue", "HP_ABNORMAL_ENZYME_ACTIVITY_IN_CULTURED_FIBROBLASTS": "Abnormal enzyme activity in cultured fibroblasts", "HP_ABNORMAL_EPIDERMAL_MORPHOLOGY": "Abnormal epidermal morphology", "HP_ABNORMAL_EOSINOPHIL_MORPHOLOGY": "Abnormal eosinophil morphology", "HP_ABNORMAL_EPIDIDYMIS_MORPHOLOGY": "Abnormal epididymis morphology", "HP_ABNORMAL_EPIGLOTTIS_MORPHOLOGY": "Abnormal epiglottis morphology", "HP_ABNORMAL_EPIPHYSEAL_OSSIFICATION": "Abnormal epiphyseal ossification", "HP_ABNORMAL_EPIPHYSIS_MORPHOLOGY_OF_THE_PHALANGES_OF_THE_HAND": "Abnormal epiphysis morphology of the phalanges of the hand", "HP_ABNORMAL_ERYTHROCYTE_ADENOSINE_DEAMINASE_ACTIVITY": "Abnormal erythrocyte adenosine deaminase activity", "HP_ABNORMAL_ERYTHROCYTE_ENZYME_CONCENTRATION_OR_ACTIVITY": "Abnormal erythrocyte enzyme concentration or activity", "HP_ABNORMAL_ENZYME_CONCENTRATION_OR_ACTIVITY": "Abnormal enzyme concentration or activity", "HP_ABNORMAL_EPIPHYSIS_MORPHOLOGY": "Abnormal epiphysis morphology", "HP_ABNORMAL_ERYTHROCYTE_PHYSIOLOGY": "Abnormal erythrocyte physiology", "HP_ABNORMAL_ERYTHROID_LINEAGE_CELL_MORPHOLOGY": "Abnormal erythroid lineage cell morphology", "HP_ABNORMAL_ERYTHROCYTE_SEDIMENTATION_RATE": "Abnormal erythrocyte sedimentation rate", "HP_ABNORMAL_EUSTACHIAN_TUBE_MORPHOLOGY": "Abnormal Eustachian tube morphology", "HP_ABNORMAL_ESOPHAGUS_MORPHOLOGY": "Abnormal esophagus morphology", "HP_ABNORMAL_ERYTHROCYTE_MORPHOLOGY": "Abnormal erythrocyte morphology", "HP_ABNORMAL_EXTEROCEPTIVE_SENSATION": "Abnormal exteroceptive sensation", "HP_ABNORMAL_EXPERIENCE_OF_REALITY": "Abnormal experience of reality", "HP_ABNORMAL_ESOPHAGUS_PHYSIOLOGY": "Abnormal esophagus physiology", "HP_ABNORMAL_EYELID_MORPHOLOGY": "", "HP_ABNORMAL_EYELASH_MORPHOLOGY": "Abnormal eyelash morphology", "HP_ABNORMAL_EXTERNAL_NOSE_MORPHOLOGY": "Abnormal external nose morphology", "HP_ABNORMAL_EYELID_PHYSIOLOGY": "Abnormal eyelid physiology", "HP_ABNORMAL_EYEBROW_MORPHOLOGY": "Abnormal eyebrow morphology", "HP_ABNORMAL_FACTOR_IX_ACTIVITY": "Abnormal factor IX activity", "HP_ABNORMAL_FACTOR_VIII_ACTIVITY": "Abnormal factor VIII activity", "HP_ABNORMAL_FACIAL_EXPRESSION": "Abnormal facial expression", "HP_ABNORMAL_FALLOPIAN_TUBE_MORPHOLOGY": "Abnormal fallopian tube morphology", "HP_ABNORMAL_FEAR_INDUCED_BEHAVIOR": "Abnormal fear-induced behavior", "HP_ABNORMAL_FEMALE_MEIOSIS": "Abnormal female meiosis", "HP_ABNORMAL_FACIAL_SHAPE": "Abnormal facial shape", "HP_ABNORMAL_FACIAL_SKELETON_MORPHOLOGY": "Abnormal facial skeleton morphology", "HP_ABNORMAL_FEMALE_EXTERNAL_GENITALIA_MORPHOLOGY": "Abnormal female external genitalia morphology", "HP_ABNORMAL_FEMALE_REPRODUCTIVE_SYSTEM_PHYSIOLOGY": "Abnormal female reproductive system physiology", "HP_ABNORMAL_FEMORAL_HEAD_MORPHOLOGY": "Abnormal femoral head morphology", "HP_ABNORMAL_FEMORAL_TORSION": "Abnormal femoral torsion", "HP_ABNORMAL_FEMORAL_NECK_HEAD_MORPHOLOGY": "Abnormal femoral neck/head morphology", "HP_ABNORMAL_FEMORAL_NECK_MORPHOLOGY": "Abnormal femoral neck morphology", "HP_ABNORMAL_FETAL_CENTRAL_NERVOUS_SYSTEM_MORPHOLOGY": "Abnormal fetal central nervous system morphology", "HP_ABNORMAL_FETAL_CARDIOVASCULAR_MORPHOLOGY": "Abnormal fetal cardiovascular morphology", "HP_ABNORMAL_FETAL_GASTROINTESTINAL_SYSTEM_MORPHOLOGY": "Abnormal fetal gastrointestinal system morphology", "HP_ABNORMAL_FEMUR_MORPHOLOGY": "Abnormal femur morphology", "HP_ABNORMAL_FETAL_GENITOURINARY_SYSTEM_MORPHOLOGY": "Abnormal fetal genitourinary system morphology", "HP_ABNORMAL_FETAL_PULMONARY_MORPHOLOGY": "Abnormal fetal pulmonary morphology", "HP_ABNORMAL_FETAL_SKIN_MORPHOLOGY": "Abnormal fetal skin morphology", "HP_ABNORMAL_FIBULA_MORPHOLOGY": "Abnormal fibula morphology", "HP_ABNORMAL_FETAL_PHYSIOLOGY": "Abnormal fetal physiology", "HP_ABNORMAL_FETAL_MORPHOLOGY": "Abnormal fetal morphology", "HP_ABNORMAL_FIFTH_TOE_MORPHOLOGY": "Abnormal fifth toe morphology", "HP_ABNORMAL_FINGER_FLEXION_CREASE": "Abnormal finger flexion crease", "HP_ABNORMAL_FINGERTIP_MORPHOLOGY": "Abnormal fingertip morphology", "HP_ABNORMAL_FINGERNAIL_MORPHOLOGY": "Abnormal fingernail morphology", "HP_ABNORMAL_FLASH_VISUAL_EVOKED_POTENTIALS": "Abnormal flash visual evoked potentials", "HP_ABNORMAL_FOOT_BONE_OSSIFICATION": "Abnormal foot bone ossification", "HP_ABNORMAL_FINGER_PHALANX_MORPHOLOGY": "Abnormal finger phalanx morphology", "HP_ABNORMAL_FORAMEN_MAGNUM_MORPHOLOGY": "Abnormal foramen magnum morphology", "HP_ABNORMAL_FOURTH_TOE_MORPHOLOGY": "Abnormal fourth toe morphology", "HP_ABNORMAL_FOURTH_VENTRICLE_MORPHOLOGY": "", "HP_ABNORMAL_FOREARM_MORPHOLOGY": "Abnormal forearm morphology", "HP_ABNORMAL_FOVEAL_MORPHOLOGY": "Abnormal foveal morphology", "HP_ABNORMAL_FOVEAL_MORPHOLOGY_ON_MACULAR_OCT": "Abnormal foveal morphology on macular OCT", "HP_ABNORMAL_FINGER_MORPHOLOGY": "Abnormal finger morphology", "HP_ABNORMAL_FORM_OF_THE_VERTEBRAL_BODIES": "Abnormal form of the vertebral bodies", "HP_ABNORMAL_FOOT_MORPHOLOGY": "Abnormal foot morphology", "HP_ABNORMAL_FRONTALIS_MUSCLE_PHYSIOLOGY": "", "HP_ABNORMAL_FRONTAL_BONE_MORPHOLOGY": "", "HP_ABNORMAL_FUNDUS_AUTOFLUORESCENCE_IMAGING": "Abnormal fundus autofluorescence imaging", "HP_ABNORMAL_FULL_FIELD_ELECTRORETINOGRAM": "Abnormal full-field electroretinogram", "HP_ABNORMAL_GALLBLADDER_PHYSIOLOGY": "Abnormal gallbladder physiology", "HP_ABNORMAL_GALLBLADDER_MORPHOLOGY": "Abnormal gallbladder morphology", "HP_ABNORMAL_GAMMA_GLUTAMYLTRANSFERASE_LEVEL": "Abnormal gamma-glutamyltransferase level", "HP_ABNORMAL_GASTRIC_MUCOSA_MORPHOLOGY": "Abnormal gastric mucosa morphology", "HP_ABNORMAL_GASTROINTESTINAL_VASCULAR_MORPHOLOGY": "Abnormal gastrointestinal vascular morphology", "HP_ABNORMAL_GASTROINTESTINAL_MOTILITY": "Abnormal gastrointestinal motility", "HP_ABNORMAL_GLIAL_CELL_MORPHOLOGY": "Abnormal glial cell morphology", "HP_ABNORMAL_GLOMERULAR_FILTRATION_RATE": "", "HP_ABNORMAL_GLOBUS_PALLIDUS_MORPHOLOGY": "Abnormal globus pallidus morphology", "HP_ABNORMAL_FUNDUS_MORPHOLOGY": "Abnormal fundus morphology", "HP_ABNORMAL_GLYCOSPHINGOLIPID_METABOLISM": "Abnormal glycosphingolipid metabolism", "HP_ABNORMAL_GLOMERULAR_MESANGIUM_MORPHOLOGY": "Abnormal glomerular mesangium morphology", "HP_ABNORMAL_GLYCOSYLATION": "Abnormal glycosylation", "HP_ABNORMAL_GRANULOCYTOPOIETIC_CELL_MORPHOLOGY": "Abnormal granulocytopoietic cell morphology", "HP_ABNORMAL_GLUCOSE_HOMEOSTASIS": "Abnormal glucose homeostasis", "HP_ABNORMAL_GREATER_SCIATIC_NOTCH_MORPHOLOGY": "Abnormal greater sciatic notch morphology", "HP_ABNORMAL_HAIRSHAFT_MORPHOLOGY": "Abnormal hairshaft morphology", "HP_ABNORMAL_GRANULOCYTE_COUNT": "Abnormal granulocyte count", "HP_ABNORMAL_GROWTH_HORMONE_LEVEL": "Abnormal growth hormone level", "HP_ABNORMAL_HAIR_WHORL": "Abnormal hair whorl", "HP_ABNORMAL_HAIR_PATTERN": "Abnormal hair pattern", "HP_ABNORMAL_HALLUX_PHALANX_MORPHOLOGY": "Abnormal hallux phalanx morphology", "HP_ABNORMAL_HALLUX_MORPHOLOGY": "Abnormal hallux morphology", "HP_ABNORMAL_HAND_BONE_OSSIFICATION": "Abnormal hand bone ossification", "HP_ABNORMAL_HAIR_QUANTITY": "Abnormal hair quantity", "HP_ABNORMAL_HARD_PALATE_MORPHOLOGY": "Abnormal hard palate morphology", "HP_ABNORMAL_HEAD_BLOOD_VESSEL_MORPHOLOGY": "Abnormal head blood vessel morphology", "HP_ABNORMAL_HEAD_MOVEMENTS": "Abnormal head movements", "HP_ABNORMAL_HEART_RATE_VARIABILITY": "Abnormal heart rate variability", "HP_ABNORMAL_HAND_MORPHOLOGY": "Abnormal hand morphology", "HP_ABNORMAL_HEART_SOUND": "Abnormal heart sound", "HP_ABNORMAL_HEMATOCRIT": "Abnormal hematocrit", "HP_ABNORMAL_HEART_MORPHOLOGY": "Abnormal heart morphology", "HP_ABNORMAL_HEMIDIAPHRAGM_MORPHOLOGY": "Abnormal hemidiaphragm morphology", "HP_ABNORMAL_HEART_VALVE_MORPHOLOGY": "Abnormal heart valve morphology", "HP_ABNORMAL_HEART_VALVE_PHYSIOLOGY": "Abnormal heart valve physiology", "HP_ABNORMAL_HELIX_MORPHOLOGY": "Abnormal helix morphology", "HP_ABNORMAL_HEMOGLOBIN": "Abnormal hemoglobin", "HP_ABNORMAL_HEMOGLOBIN_CONCENTRATION": "Abnormal hemoglobin concentration", "HP_ABNORMAL_HEPATIC_ECHOGENICITY": "", "HP_ABNORMAL_HUMERUS_MORPHOLOGY": "Abnormal humerus morphology", "HP_ABNORMAL_HIP_JOINT_MORPHOLOGY": "Abnormal hip joint morphology", "HP_ABNORMAL_HYPOTHALAMUS_MORPHOLOGY": "Abnormal hypothalamus morphology", "HP_ABNORMAL_HYPNAGOGIA": "", "HP_ABNORMAL_HYPOTHALAMUS_PHYSIOLOGY": "Abnormal hypothalamus physiology", "HP_ABNORMAL_ILEUM_MORPHOLOGY": "Abnormal ileum morphology", "HP_ABNORMAL_ILIAC_WING_MORPHOLOGY": "Abnormal iliac wing morphology", "HP_ABNORMAL_IMMUNE_SERUM_PROTEIN_PHYSIOLOGY": "Abnormal immune serum protein physiology", "HP_ABNORMAL_ILIUM_MORPHOLOGY": "Abnormal ilium morphology", "HP_ABNORMAL_INFERIOR_VENA_CAVA_MORPHOLOGY": "", "HP_ABNORMAL_INTERNAL_CAROTID_ARTERY_MORPHOLOGY": "Abnormal internal carotid artery morphology", "HP_ABNORMAL_INCISOR_MORPHOLOGY": "Abnormal incisor morphology", "HP_ABNORMAL_IMMUNE_SYSTEM_MORPHOLOGY": "Abnormal immune system morphology", "HP_ABNORMAL_INTRAHEPATIC_BILE_DUCT_MORPHOLOGY": "Abnormal intrahepatic bile duct morphology", "HP_ABNORMAL_INTERVERTEBRAL_DISK_MORPHOLOGY": "Abnormal intervertebral disk morphology", "HP_ABNORMAL_INTERNAL_GENITALIA": "Abnormal internal genitalia", "HP_ABNORMAL_INVOLUNTARY_EYE_MOVEMENTS": "", "HP_ABNORMAL_INTRAOCULAR_PRESSURE": "Abnormal intraocular pressure", "HP_ABNORMAL_INTONATION": "Abnormal Intonation", "HP_ABNORMAL_ISCHIUM_MORPHOLOGY": "Abnormal ischium morphology", "HP_ABNORMAL_INTESTINE_MORPHOLOGY": "Abnormal intestine morphology", "HP_ABNORMAL_IRIS_PIGMENTATION": "Abnormal iris pigmentation", "HP_ABNORMAL_ISOHEMAGGLUTININ_LEVEL": "Abnormal isohemagglutinin level", "HP_ABNORMAL_JEJUNUM_MORPHOLOGY": "Abnormal jejunum morphology", "HP_ABNORMAL_KNEE_PHYSIOLOGY": "Abnormal knee physiology", "HP_ABNORMAL_LABIA_MAJORA_MORPHOLOGY": "Abnormal labia majora morphology", "HP_ABNORMAL_JAW_MORPHOLOGY": "Abnormal jaw morphology", "HP_ABNORMAL_LACRIMAL_GLAND_MORPHOLOGY": "Abnormal lacrimal gland morphology", "HP_ABNORMAL_LACRIMAL_PUNCTUM_MORPHOLOGY": "Abnormal lacrimal punctum morphology", "HP_ABNORMAL_LABIA_MORPHOLOGY": "Abnormal labia morphology", "HP_ABNORMAL_LABIA_MINORA_MORPHOLOGY": "Abnormal labia minora morphology", "HP_ABNORMAL_LACRIMAL_DUCT_MORPHOLOGY": "Abnormal lacrimal duct morphology", "HP_ABNORMAL_JUDGMENT": "Abnormal judgment", "HP_ABNORMAL_JOINT_MORPHOLOGY": "Abnormal joint morphology", "HP_ABNORMAL_LARGE_INTESTINE_PHYSIOLOGY": "Abnormal large intestine physiology", "HP_ABNORMAL_LARYNX_MORPHOLOGY": "Abnormal larynx morphology", "HP_ABNORMAL_LARGE_INTESTINE_MORPHOLOGY": "Abnormal large intestine morphology", "HP_ABNORMAL_LARYNX_PHYSIOLOGY": "Abnormal larynx physiology", "HP_ABNORMAL_LDL_CHOLESTEROL_CONCENTRATION": "Abnormal LDL cholesterol concentration", "HP_ABNORMAL_LEFT_VENTRICULAR_OUTFLOW_TRACT_MORPHOLOGY": "Abnormal left ventricular outflow tract morphology", "HP_ABNORMAL_LATERAL_VENTRICLE_MORPHOLOGY": "Abnormal lateral ventricle morphology", "HP_ABNORMAL_LEFT_ATRIUM_MORPHOLOGY": "Abnormal left atrium morphology", "HP_ABNORMAL_LENGTH_OF_CORPUS_CALLOSUM": "", "HP_ABNORMAL_LEFT_VENTRICLE_MORPHOLOGY": "Abnormal left ventricle morphology", "HP_ABNORMAL_LEUKOCYTE_ENZYME_CONCENTRATION_OR_ACTIVITY": "Abnormal leukocyte enzyme concentration or activity", "HP_ABNORMAL_LEUKOCYTE_COUNT": "Abnormal leukocyte count", "HP_ABNORMAL_LENS_MORPHOLOGY": "Abnormal lens morphology", "HP_ABNORMAL_LIGHT_ADAPTED_ELECTRORETINOGRAM": "Abnormal light-adapted electroretinogram", "HP_ABNORMAL_LIBIDO": "", "HP_ABNORMAL_LEUKOCYTE_PHYSIOLOGY": "Abnormal leukocyte physiology", "HP_ABNORMAL_LIVER_ENZYME_ACTIVITY_OR_CONCENTRATION": "Abnormal liver enzyme activity or concentration", "HP_ABNORMAL_LIGHT_AND_DARK_ADAPTED_ELECTRORETINOGRAM": "Abnormal light- and dark-adapted electroretinogram", "HP_ABNORMAL_LIMB_EPIPHYSIS_MORPHOLOGY": "Abnormal limb epiphysis morphology", "HP_ABNORMAL_LIVER_METABOLITE_CONCENTRATION": "Abnormal liver metabolite concentration", "HP_ABNORMAL_LIP_MORPHOLOGY": "Abnormal lip morphology", "HP_ABNORMAL_LIVER_PHYSIOLOGY": "Abnormal liver physiology", "HP_ABNORMAL_LIVER_PARENCHYMA_MORPHOLOGY": "Abnormal liver parenchyma morphology", "HP_ABNORMAL_LOWER_LIMB_METAPHYSIS_MORPHOLOGY": "Abnormal lower-limb metaphysis morphology", "HP_ABNORMAL_LOCALIZATION_OF_KIDNEY": "Abnormal localization of kidney", "HP_ABNORMAL_LOWER_LIMB_EPIPHYSIS_MORPHOLOGY": "Abnormal lower limb epiphysis morphology", "HP_ABNORMAL_LIVER_MORPHOLOGY": "Abnormal liver morphology", "HP_ABNORMAL_LOWER_LIMB_MOTOR_EVOKED_POTENTIALS": "Abnormal lower-limb motor evoked potentials", "HP_ABNORMAL_LOWER_MOTOR_NEURON_MORPHOLOGY": "Abnormal lower motor neuron morphology", "HP_ABNORMAL_LONG_BONE_MORPHOLOGY": "Abnormal long bone morphology", "HP_ABNORMAL_LUMBAR_SPINE_MORPHOLOGY": "Abnormal lumbar spine morphology", "HP_ABNORMAL_LOWER_LIMB_BONE_MORPHOLOGY": "Abnormal lower limb bone morphology", "HP_ABNORMAL_LOWER_LIP_MORPHOLOGY": "Abnormal lower lip morphology", "HP_ABNORMAL_LUNG_MORPHOLOGY": "", "HP_ABNORMAL_LUNG_DEVELOPMENT": "Abnormal lung development", "HP_ABNORMAL_LYMPHOCYTE_APOPTOSIS": "", "HP_ABNORMAL_LUNG_LOBATION": "Abnormal lung lobation", "HP_ABNORMAL_LYMPHATIC_VESSEL_MORPHOLOGY": "Abnormal lymphatic vessel morphology", "HP_ABNORMAL_LYMPHOCYTE_PROLIFERATION": "Abnormal lymphocyte proliferation", "HP_ABNORMAL_MACROPHAGE_MORPHOLOGY": "Abnormal macrophage morphology", "HP_ABNORMAL_LYMPHOCYTE_MORPHOLOGY": "Abnormal lymphocyte morphology", "HP_ABNORMAL_MACROSCOPIC_URINE_APPEARANCE": "Abnormal macroscopic urine appearance", "HP_ABNORMAL_LYMPH_NODE_MORPHOLOGY": "Abnormal lymph node morphology", "HP_ABNORMAL_MAGNESIUM_CONCENTRATION": "Abnormal magnesium concentration", "HP_ABNORMAL_MACULAR_MORPHOLOGY": "Abnormal macular morphology", "HP_ABNORMAL_MALE_GERM_CELL_MORPHOLOGY": "Abnormal male germ cell morphology", "HP_ABNORMAL_MALE_INTERNAL_GENITALIA_MORPHOLOGY": "Abnormal male internal genitalia morphology", "HP_ABNORMAL_MASTOID_MORPHOLOGY": "Abnormal mastoid morphology", "HP_ABNORMAL_MAST_CELL_MORPHOLOGY": "Abnormal mast cell morphology", "HP_ABNORMAL_MALE_REPRODUCTIVE_SYSTEM_PHYSIOLOGY": "Abnormal male reproductive system physiology", "HP_ABNORMAL_MATERNAL_SERUM_SCREENING": "Abnormal maternal serum screening", "HP_ABNORMAL_MEAN_CORPUSCULAR_HEMOGLOBIN_CONCENTRATION": "Abnormal mean corpuscular hemoglobin concentration", "HP_ABNORMAL_MEAN_CORPUSCULAR_VOLUME": "Abnormal mean corpuscular volume", "HP_ABNORMAL_MAXILLA_MORPHOLOGY": "Abnormal maxilla morphology", "HP_ABNORMAL_MEGAKARYOCYTE_MORPHOLOGY": "Abnormal megakaryocyte morphology", "HP_ABNORMAL_MESENTERY_MORPHOLOGY": "Abnormal mesentery morphology", "HP_ABNORMAL_MENINGEAL_MORPHOLOGY": "Abnormal meningeal morphology", "HP_ABNORMAL_METABOLIC_BRAIN_IMAGING_BY_MRS": "Abnormal metabolic brain imaging by MRS", "HP_ABNORMAL_METACARPAL_EPIPHYSIS_MORPHOLOGY": "Abnormal metacarpal epiphysis morphology", "HP_ABNORMAL_METACARPOPHALANGEAL_JOINT_MORPHOLOGY": "Abnormal metacarpophalangeal joint morphology", "HP_ABNORMAL_METABOLISM": "Abnormal metabolism", "HP_ABNORMAL_METAPHYSEAL_TRABECULATION": "Abnormal metaphyseal trabeculation", "HP_ABNORMAL_METACARPAL_MORPHOLOGY": "Abnormal metacarpal morphology", "HP_ABNORMAL_METAPHYSIS_MORPHOLOGY": "Abnormal metaphysis morphology", "HP_ABNORMAL_MIDDLE_EAR_REFLEXES": "Abnormal middle ear reflexes", "HP_ABNORMAL_METATARSAL_MORPHOLOGY": "Abnormal metatarsal morphology", "HP_ABNORMAL_MIDDLE_PHALANX_MORPHOLOGY_OF_THE_HAND": "Abnormal middle phalanx morphology of the hand", "HP_ABNORMAL_MIDBRAIN_MORPHOLOGY": "Abnormal midbrain morphology", "HP_ABNORMAL_MITOCHONDRIAL_MORPHOLOGY": "Abnormal mitochondrial morphology", "HP_ABNORMAL_METENCEPHALON_MORPHOLOGY": "Abnormal metencephalon morphology", "HP_ABNORMAL_MITOCHONDRIAL_NUMBER": "Abnormal mitochondrial number", "HP_ABNORMAL_MIDDLE_EAR_MORPHOLOGY": "Abnormal middle ear morphology", "HP_ABNORMAL_MITOCHONDRIAL_SHAPE": "Abnormal mitochondrial shape", "HP_ABNORMAL_MITOCHONDRIA_IN_MUSCLE_TISSUE": "Abnormal mitochondria in muscle tissue", "HP_ABNORMAL_MIDFACE_MORPHOLOGY": "Abnormal midface morphology", "HP_ABNORMAL_MORPHOLOGY_OF_MUSCULATURE_OF_PHARYNX": "", "HP_ABNORMAL_MONOCYTE_COUNT": "Abnormal monocyte count", "HP_ABNORMAL_MORPHOLOGY_OF_MYOCARDIAL_TRABECULAE": "Abnormal morphology of myocardial trabeculae", "HP_ABNORMAL_MITRAL_VALVE_PHYSIOLOGY": "Abnormal mitral valve physiology", "HP_ABNORMAL_MORPHOLOGY_OF_THE_CHOROIDAL_VASCULATURE": "Abnormal morphology of the choroidal vasculature", "HP_ABNORMAL_MORPHOLOGY_OF_THE_ABDOMINAL_MUSCULATURE": "Abnormal morphology of the abdominal musculature", "HP_ABNORMAL_MORPHOLOGY_OF_THE_CONJUNCTIVAL_VASCULATURE": "Abnormal morphology of the conjunctival vasculature", "HP_ABNORMAL_MORPHOLOGY_OF_THE_LIMBIC_SYSTEM": "Abnormal morphology of the limbic system", "HP_ABNORMAL_MORPHOLOGY_OF_THE_PROXIMAL_PHALANX_OF_THE_HALLUX": "Abnormal morphology of the proximal phalanx of the hallux", "HP_ABNORMAL_MORPHOLOGY_OF_THE_MUSCULATURE_OF_THE_NECK": "Abnormal morphology of the musculature of the neck", "HP_ABNORMAL_MORPHOLOGY_OF_THE_OLFACTORY_BULB": "Abnormal morphology of the olfactory bulb", "HP_ABNORMAL_MORPHOLOGY_OF_THE_GREAT_VESSELS": "Abnormal morphology of the great vessels", "HP_ABNORMAL_MOTOR_EVOKED_POTENTIALS": "Abnormal motor evoked potentials", "HP_ABNORMAL_MORPHOLOGY_OF_THE_VESTIBULE_OF_THE_INNER_EAR": "Abnormal morphology of the vestibule of the inner ear", "HP_ABNORMAL_MOTOR_NERVE_CONDUCTION_VELOCITY": "Abnormal motor nerve conduction velocity", "HP_ABNORMAL_MORPHOLOGY_OF_ULNA": "Abnormal morphology of ulna", "HP_ABNORMAL_MUSCLE_FIBER_ALPHA_DYSTROGLYCAN": "Abnormal muscle fiber alpha dystroglycan", "HP_ABNORMAL_MUSCLE_FIBER_MEROSIN_EXPRESSION": "Abnormal muscle fiber merosin expression", "HP_ABNORMAL_MORPHOLOGY_OF_THE_NASAL_ALAE": "Abnormal morphology of the nasal alae", "HP_ABNORMAL_MUSCLE_FIBER_PROTEIN_EXPRESSION": "Abnormal muscle fiber protein expression", "HP_ABNORMAL_MUSCLE_GLYCOGEN_CONTENT": "Abnormal muscle glycogen content", "HP_ABNORMAL_MUSCLE_FIBER_MORPHOLOGY": "Abnormal muscle fiber morphology", "HP_ABNORMAL_MUSCULOSKELETAL_PHYSIOLOGY": "", "HP_ABNORMAL_MUSCLE_FIBER_TYPE_DISTRIBUTION": "Abnormal muscle fiber-type distribution", "HP_ABNORMAL_MUSCLE_TISSUE_METABOLITE_CONCENTRATION": "Abnormal muscle tissue metabolite concentration", "HP_ABNORMAL_NASAL_BASE_NORPHOLOGY": "Abnormal nasal base norphology", "HP_ABNORMAL_NASAL_BONE_MORPHOLOGY": "Abnormal nasal bone morphology", "HP_ABNORMAL_MYELOID_LEUKOCYTE_MORPHOLOGY": "Abnormal myeloid leukocyte morphology", "HP_ABNORMAL_MYELINATION": "Abnormal myelination", "HP_ABNORMAL_MYOCARDIUM_MORPHOLOGY": "Abnormal myocardium morphology", "HP_ABNORMAL_NASAL_CAVITY_MORPHOLOGY": "Abnormal nasal cavity morphology", "HP_ABNORMAL_NASAL_MUCOSA_MORPHOLOGY": "Abnormal nasal mucosa morphology", "HP_ABNORMAL_NASAL_SEPTUM_MORPHOLOGY": "Abnormal nasal septum morphology", "HP_ABNORMAL_NASAL_DORSUM_MORPHOLOGY": "Abnormal nasal dorsum morphology", "HP_ABNORMAL_NASAL_SKELETON_MORPHOLOGY": "Abnormal nasal skeleton morphology", "HP_ABNORMAL_NASOLABIAL_REGION_MORPHOLOGY": "Abnormal nasolabial region morphology", "HP_ABNORMAL_NASAL_BRIDGE_MORPHOLOGY": "Abnormal nasal bridge morphology", "HP_ABNORMAL_NASOLACRIMAL_SYSTEM_MORPHOLOGY": "Abnormal nasolacrimal system morphology", "HP_ABNORMAL_NASAL_MORPHOLOGY": "Abnormal nasal morphology", "HP_ABNORMAL_NASOPHARYNX_MORPHOLOGY": "Abnormal nasopharynx morphology", "HP_ABNORMAL_NASAL_TIP_MORPHOLOGY": "Abnormal nasal tip morphology", "HP_ABNORMAL_NATURAL_KILLER_CELL_MORPHOLOGY": "Abnormal natural killer cell morphology", "HP_ABNORMAL_NECK_PHYSIOLOGY": "", "HP_ABNORMAL_NERVE_CONDUCTION_VELOCITY": "Abnormal nerve conduction velocity", "HP_ABNORMAL_NEURON_MORPHOLOGY": "Abnormal neuron morphology", "HP_ABNORMAL_NEPHRON_MORPHOLOGY": "Abnormal nephron morphology", "HP_ABNORMAL_NEUTROPHIL_COUNT": "", "HP_ABNORMAL_NUMBER_OF_DENSE_GRANULES": "Abnormal number of dense granules", "HP_ABNORMAL_NERVOUS_SYSTEM_ELECTROPHYSIOLOGY": "Abnormal nervous system electrophysiology", "HP_ABNORMAL_NONVERBAL_COMMUNICATIVE_BEHAVIOR": "Abnormal nonverbal communicative behavior", "HP_ABNORMAL_NEUTROPHIL_MORPHOLOGY": "Abnormal neutrophil morphology", "HP_ABNORMAL_NIPPLE_MORPHOLOGY": "Abnormal nipple morphology", "HP_ABNORMAL_NUMBER_OF_ERYTHROID_PRECURSORS": "Abnormal number of erythroid precursors", "HP_ABNORMAL_NUMBER_OF_GRANULOCYTE_PRECURSORS": "Abnormal number of granulocyte precursors", "HP_ABNORMAL_NUMBER_OF_INCISORS": "Abnormal number of incisors", "HP_ABNORMAL_NUMBER_OF_PERMANENT_TEETH": "Abnormal number of permanent teeth", "HP_ABNORMAL_NOSTRIL_MORPHOLOGY": "Abnormal nostril morphology", "HP_ABNORMAL_NUMBER_OF_VERTEBRAE": "Abnormal number of vertebrae", "HP_ABNORMAL_OOCYTE_MORPHOLOGY": "Abnormal oocyte morphology", "HP_ABNORMAL_OLFACTORY_LOBE_MORPHOLOGY": "Abnormal olfactory lobe morphology", "HP_ABNORMAL_ODONTOID_PROCESS_MORPHOLOGY": "Abnormal odontoid process morphology", "HP_ABNORMAL_OCCIPITAL_BONE_MORPHOLOGY": "Abnormal occipital bone morphology", "HP_ABNORMAL_OPTICAL_COHERENCE_TOMOGRAPHY": "", "HP_ABNORMAL_OPTIC_CHIASM_MORPHOLOGY": "Abnormal optic chiasm morphology", "HP_ABNORMAL_ODONTOID_TISSUE_MORPHOLOGY": "Abnormal odontoid tissue morphology", "HP_ABNORMAL_NUMBER_OF_TEETH": "Abnormal number of teeth", "HP_ABNORMAL_ORAL_FRENULUM_MORPHOLOGY": "Abnormal oral frenulum morphology", "HP_ABNORMAL_ORAL_GLUCOSE_TOLERANCE": "Abnormal oral glucose tolerance", "HP_ABNORMAL_OSSIFICATION_INVOLVING_THE_FEMORAL_HEAD_AND_NECK": "Abnormal ossification involving the femoral head and neck", "HP_ABNORMAL_OSSIFICATION_OF_THE_PUBIC_BONE": "Abnormal ossification of the pubic bone", "HP_ABNORMAL_OPTIC_NERVE_MORPHOLOGY": "Abnormal optic nerve morphology", "HP_ABNORMAL_OVARIAN_PHYSIOLOGY": "Abnormal ovarian physiology", "HP_ABNORMAL_ORAL_PHYSIOLOGY": "Abnormal oral physiology", "HP_ABNORMAL_ORAL_MUCOSA_MORPHOLOGY": "Abnormal oral mucosa morphology", "HP_ABNORMAL_OVARIAN_MORPHOLOGY": "Abnormal ovarian morphology", "HP_ABNORMAL_PANCREAS_MORPHOLOGY": "Abnormal pancreas morphology", "HP_ABNORMAL_PALATE_MORPHOLOGY": "Abnormal palate morphology", "HP_ABNORMAL_PALMAR_DERMATOGLYPHICS": "Abnormal palmar dermatoglyphics", "HP_ABNORMAL_PARIETAL_BONE_MORPHOLOGY": "Abnormal parietal bone morphology", "HP_ABNORMAL_PARATHYROID_MORPHOLOGY": "Abnormal parathyroid morphology", "HP_ABNORMAL_PAROTID_GLAND_MORPHOLOGY": "Abnormal parotid gland morphology", "HP_ABNORMAL_PALM_MORPHOLOGY": "Abnormal palm morphology", "HP_ABNORMAL_PANCREAS_SIZE": "Abnormal pancreas size", "HP_ABNORMAL_PATELLA_MORPHOLOGY": "Abnormal patella morphology", "HP_ABNORMAL_PARANASAL_SINUS_MORPHOLOGY": "Abnormal paranasal sinus morphology", "HP_ABNORMAL_PATTERN_ELECTRORETINOGRAM": "", "HP_ABNORMAL_PEER_RELATIONSHIPS": "", "HP_ABNORMAL_PELVIS_BONE_MORPHOLOGY": "Abnormal pelvis bone morphology", "HP_ABNORMAL_PELVIS_BONE_OSSIFICATION": "Abnormal pelvis bone ossification", "HP_ABNORMAL_PERIAURICULAR_REGION_MORPHOLOGY": "Abnormal periauricular region morphology", "HP_ABNORMAL_PERICARDIUM_MORPHOLOGY": "Abnormal pericardium morphology", "HP_ABNORMAL_PERIFOLLICULAR_MORPHOLOGY": "Abnormal perifollicular morphology", "HP_ABNORMAL_PERIOSTEUM_MORPHOLOGY": "Abnormal periosteum morphology", "HP_ABNORMAL_PELVIC_GIRDLE_BONE_MORPHOLOGY": "Abnormal pelvic girdle bone morphology", "HP_ABNORMAL_PATTERN_OF_RESPIRATION": "Abnormal pattern of respiration", "HP_ABNORMAL_PERIPHERAL_ACTION_POTENTIAL_AMPLITUDE": "Abnormal peripheral action potential amplitude", "HP_ABNORMAL_PENIS_MORPHOLOGY": "Abnormal penis morphology", "HP_ABNORMAL_PERIPHERAL_MYELINATION": "Abnormal peripheral myelination", "HP_ABNORMAL_PERISTALSIS": "Abnormal peristalsis", "HP_ABNORMAL_PERITONEUM_MORPHOLOGY": "Abnormal peritoneum morphology", "HP_ABNORMAL_PERIPHERAL_NERVOUS_SYSTEM_MORPHOLOGY": "Abnormal peripheral nervous system morphology", "HP_ABNORMAL_PERIVENTRICULAR_WHITE_MATTER_MORPHOLOGY": "Abnormal periventricular white matter morphology", "HP_ABNORMAL_PHAGOCYTOSIS": "", "HP_ABNORMAL_PERIPHERAL_NERVOUS_SYSTEM_PHYSIOLOGY": "Abnormal peripheral nervous system physiology", "HP_ABNORMAL_PINEAL_MORPHOLOGY": "Abnormal pineal morphology", "HP_ABNORMAL_PIGMENTATION_OF_THE_ORAL_MUCOSA": "Abnormal pigmentation of the oral mucosa", "HP_ABNORMAL_PHALANGEAL_JOINT_MORPHOLOGY_OF_THE_HAND": "Abnormal phalangeal joint morphology of the hand", "HP_ABNORMAL_PLACENTAL_MEMBRANE_MORPHOLOGY": "Abnormal placental membrane morphology", "HP_ABNORMAL_PLACENTAL_SIZE": "Abnormal placental size", "HP_ABNORMAL_PITUITARY_GLAND_MORPHOLOGY": "Abnormal pituitary gland morphology", "HP_ABNORMAL_PLACENTA_MORPHOLOGY": "Abnormal placenta morphology", "HP_ABNORMAL_PLATELET_AGGREGATION": "Abnormal platelet aggregation", "HP_ABNORMAL_PLATELET_FUNCTION": "Abnormal platelet function", "HP_ABNORMAL_PLATELET_GRANULES": "Abnormal platelet granules", "HP_ABNORMAL_PLATELET_MEMBRANE_PROTEIN_EXPRESSION": "Abnormal platelet membrane protein expression", "HP_ABNORMAL_PLATELET_VOLUME": "Abnormal platelet volume", "HP_ABNORMAL_PONS_MORPHOLOGY": "Abnormal pons morphology", "HP_ABNORMAL_PLEURA_MORPHOLOGY": "Abnormal pleura morphology", "HP_ABNORMAL_PORTAL_VENOUS_SYSTEM_MORPHOLOGY": "Abnormal portal venous system morphology", "HP_ABNORMAL_POSTERIOR_SEGMENT_IMAGING": "Abnormal posterior segment imaging", "HP_ABNORMAL_POSTURING": "Abnormal posturing", "HP_ABNORMAL_POSTERIOR_PITUITARY_MORPHOGENESIS": "Abnormal posterior pituitary morphogenesis", "HP_ABNORMAL_PREIMPLANTATION_EMBRYONIC_DEVELOPMENT": "Abnormal preimplantation embryonic development", "HP_ABNORMAL_PROLACTIN_LEVEL": "Abnormal prolactin level", "HP_ABNORMAL_PROPORTION_OF_CD4_POSITIVE_HELPER_T_CELLS": "", "HP_ABNORMAL_PREPUTIUM_MORPHOLOGY": "Abnormal preputium morphology", "HP_ABNORMAL_PROPORTION_OF_CD4_POSITIVE_T_CELLS": "", "HP_ABNORMAL_PROPORTION_OF_CD8_POSITIVE_T_CELLS": "", "HP_ABNORMAL_PROPORTION_OF_CLASS_SWITCHED_MEMORY_B_CELLS": "", "HP_ABNORMAL_PROPORTION_OF_MEMORY_T_CELLS": "", "HP_ABNORMAL_PROTEIN_GLYCOSYLATION": "", "HP_ABNORMAL_PROPORTION_OF_NAIVE_T_CELLS": "", "HP_ABNORMAL_PROPORTION_OF_DOUBLE_NEGATIVE_ALPHA_BETA_REGULATORY_T_CELL": "", "HP_ABNORMAL_PROSODY": "Abnormal prosody", "HP_ABNORMAL_PROSTATE_MORPHOLOGY": "Abnormal prostate morphology", "HP_ABNORMAL_PROTEIN_O_LINKED_GLYCOSYLATION": "Abnormal protein O-linked glycosylation", "HP_ABNORMAL_PROXIMAL_FEMORAL_METAPHYSIS_MORPHOLOGY": "Abnormal proximal femoral metaphysis morphology", "HP_ABNORMAL_PR_INTERVAL": "Abnormal PR interval", "HP_ABNORMAL_PROXIMAL_PHALANX_MORPHOLOGY_OF_THE_HAND": "Abnormal proximal phalanx morphology of the hand", "HP_ABNORMAL_PUBIC_BONE_MORPHOLOGY": "Abnormal pubic bone morphology", "HP_ABNORMAL_PULMONARY_ALVEOLAR_SYSTEM_MORPHOLOGY": "Abnormal pulmonary alveolar system morphology", "HP_ABNORMAL_PSYCHOTIC_PATTERN": "Abnormal psychotic pattern", "HP_ABNORMAL_PULMONARY_VALVE_CUSP_MORPHOLOGY": "", "HP_ABNORMAL_PULMONARY_INTERSTITIAL_MORPHOLOGY": "Abnormal pulmonary interstitial morphology", "HP_ABNORMAL_PULMONARY_THORACIC_IMAGING_FINDING": "Abnormal pulmonary thoracic imaging finding", "HP_ABNORMAL_PULMONARY_VALVE_MORPHOLOGY": "Abnormal pulmonary valve morphology", "HP_ABNORMAL_PULSE": "Abnormal pulse", "HP_ABNORMAL_PULMONARY_VEIN_MORPHOLOGY": "Abnormal pulmonary vein morphology", "HP_ABNORMAL_PULMONARY_VALVE_PHYSIOLOGY": "Abnormal pulmonary valve physiology", "HP_ABNORMAL_PUPILLARY_LIGHT_REFLEX": "Abnormal pupillary light reflex", "HP_ABNORMAL_PUPILLARY_FUNCTION": "Abnormal pupillary function", "HP_ABNORMAL_PUTAMEN_MORPHOLOGY": "Abnormal putamen morphology", "HP_ABNORMAL_PUPIL_MORPHOLOGY": "Abnormal pupil morphology", "HP_ABNORMAL_P_WAVE": "Abnormal P wave", "HP_ABNORMAL_QRS_COMPLEX": "Abnormal QRS complex", "HP_ABNORMAL_PYRAMIDAL_SIGN": "", "HP_ABNORMAL_PYRAMIDAL_TRACT_MORPHOLOGY": "Abnormal pyramidal tract morphology", "HP_ABNORMAL_RAPID_EYE_MOVEMENT_SLEEP": "Abnormal rapid eye movement sleep", "HP_ABNORMAL_QT_INTERVAL": "Abnormal QT interval", "HP_ABNORMAL_RECTUM_MORPHOLOGY": "Abnormal rectum morphology", "HP_ABNORMAL_RELATIONSHIP": "Abnormal relationship", "HP_ABNORMAL_RENAL_COLLECTING_SYSTEM_MORPHOLOGY": "Abnormal renal collecting system morphology", "HP_ABNORMAL_RENAL_CORTICOMEDULLARY_DIFFERENTIATION": "Abnormal renal corticomedullary differentiation", "HP_ABNORMAL_RENAL_ECHOGENICITY": "Abnormal renal echogenicity", "HP_ABNORMAL_RENAL_CORTEX_MORPHOLOGY": "Abnormal renal cortex morphology", "HP_ABNORMAL_RENAL_INSTERSTITIAL_MORPHOLOGY": "Abnormal renal insterstitial morphology", "HP_ABNORMAL_RENAL_MEDULLA_MORPHOLOGY": "Abnormal renal medulla morphology", "HP_ABNORMAL_RENAL_CORPUSCLE_MORPHOLOGY": "Abnormal renal corpuscle morphology", "HP_ABNORMAL_REFLEX": "Abnormal reflex", "HP_ABNORMAL_RENAL_TUBULAR_LUMEN_MORPHOLOGY": "Abnormal renal tubular lumen morphology", "HP_ABNORMAL_RENAL_PELVIS_MORPHOLOGY": "Abnormal renal pelvis morphology", "HP_ABNORMAL_RENAL_TUBULAR_RESORPTION": "Abnormal renal tubular resorption", "HP_ABNORMAL_RENAL_PHYSIOLOGY": "Abnormal renal physiology", "HP_ABNORMAL_RENAL_VASCULAR_MORPHOLOGY": "Abnormal renal vascular morphology", "HP_ABNORMAL_RENAL_TUBULE_MORPHOLOGY": "Abnormal renal tubule morphology", "HP_ABNORMAL_RESPIRATORY_EPITHELIUM_MORPHOLOGY": "", "HP_ABNORMAL_RENAL_MORPHOLOGY": "Abnormal renal morphology", "HP_ABNORMAL_RESPIRATORY_MOTILE_CILIUM_PHYSIOLOGY": "Abnormal respiratory motile cilium physiology", "HP_ABNORMAL_RESPONSE_TO_ACTH_STIMULATION_TEST": "Abnormal response to ACTH stimulation test", "HP_ABNORMAL_RESPONSE_TO_ENDOCRINE_STIMULATION_TEST": "Abnormal response to endocrine stimulation test", "HP_ABNORMAL_RESPONSE_TO_GLUCAGON_STIMULATION_TEST": "Abnormal response to glucagon stimulation test", "HP_ABNORMAL_RESPONSE_TO_INSULIN_TOLERANCE_TEST": "Abnormal response to insulin tolerance test", "HP_ABNORMAL_REPRODUCTIVE_SYSTEM_MORPHOLOGY": "Abnormal reproductive system morphology", "HP_ABNORMAL_RESPONSE_TO_SOCIAL_NORMS": "Abnormal response to social norms", "HP_ABNORMAL_RETINAL_NERVE_FIBER_LAYER_MORPHOLOGY": "Abnormal retinal nerve fiber layer morphology", "HP_ABNORMAL_RETICULOCYTE_MORPHOLOGY": "Abnormal reticulocyte morphology", "HP_ABNORMAL_RESPIRATORY_SYSTEM_MORPHOLOGY": "Abnormal respiratory system morphology", "HP_ABNORMAL_RETINAL_VASCULAR_MORPHOLOGY": "Abnormal retinal vascular morphology", "HP_ABNORMAL_RIGHT_VENTRICULAR_FUNCTION": "Abnormal right ventricular function", "HP_ABNORMAL_RIB_OSSIFICATION": "Abnormal rib ossification", "HP_ABNORMAL_RETINAL_MORPHOLOGY": "Abnormal retinal morphology", "HP_ABNORMAL_RIB_MORPHOLOGY": "Abnormal rib morphology", "HP_ABNORMAL_SACCADIC_EYE_MOVEMENTS": "Abnormal saccadic eye movements", "HP_ABNORMAL_RIGHT_VENTRICLE_MORPHOLOGY": "Abnormal right ventricle morphology", "HP_ABNORMAL_SACROILIAC_JOINT_MORPHOLOGY": "Abnormal sacroiliac joint morphology", "HP_ABNORMAL_RIB_CAGE_MORPHOLOGY": "Abnormal rib cage morphology", "HP_ABNORMAL_SALIVARY_GLAND_MORPHOLOGY": "Abnormal salivary gland morphology", "HP_ABNORMAL_SACRUM_MORPHOLOGY": "Abnormal sacrum morphology", "HP_ABNORMAL_SARCOMERE_MORPHOLOGY": "Abnormal sarcomere morphology", "HP_ABNORMAL_SECOND_TOE_MORPHOLOGY": "Abnormal second toe morphology", "HP_ABNORMAL_SCROTAL_RUGATION": "Abnormal scrotal rugation", "HP_ABNORMAL_SCAPULA_MORPHOLOGY": "Abnormal scapula morphology", "HP_ABNORMAL_SEMICIRCULAR_CANAL_MORPHOLOGY": "Abnormal semicircular canal morphology", "HP_ABNORMAL_SCROTUM_MORPHOLOGY": "Abnormal scrotum morphology", "HP_ABNORMAL_SCLERA_MORPHOLOGY": "Abnormal sclera morphology", "HP_ABNORMAL_SENSORY_NERVE_CONDUCTION_VELOCITY": "Abnormal sensory nerve conduction velocity", "HP_ABNORMAL_SELLA_TURCICA_MORPHOLOGY": "Abnormal sella turcica morphology", "HP_ABNORMAL_SCALP_MORPHOLOGY": "Abnormal scalp morphology", "HP_ABNORMAL_SEPTUM_PELLUCIDUM_MORPHOLOGY": "Abnormal septum pellucidum morphology", "HP_ABNORMAL_SERUM_BICARBONATE_CONCENTRATION": "Abnormal serum bicarbonate concentration", "HP_ABNORMAL_SERUM_BILE_ACID_CONCENTRATION": "Abnormal serum bile acid concentration", "HP_ABNORMAL_SERUM_INSULIN_LIKE_GROWTH_FACTOR_1_LEVEL": "", "HP_ABNORMAL_SERUM_ESTRADIOL": "Abnormal serum estradiol", "HP_ABNORMAL_SEX_DETERMINATION": "Abnormal sex determination", "HP_ABNORMAL_SHAPE_OF_THE_RADIUS": "", "HP_ABNORMAL_SEXUAL_BEHAVIOR": "Abnormal sexual behavior", "HP_ABNORMAL_SHAPE_OF_THE_PALPEBRAL_FISSURE": "Abnormal shape of the palpebral fissure", "HP_ABNORMAL_SHARPEY_FIBER_MORPHOLOGY": "Abnormal Sharpey fiber morphology", "HP_ABNORMAL_SEVENTH_CRANIAL_PHYSIOLOGY": "Abnormal seventh cranial physiology", "HP_ABNORMAL_SHOULDER_PHYSIOLOGY": "Abnormal shoulder physiology", "HP_ABNORMAL_SHOULDER_MORPHOLOGY": "Abnormal shoulder morphology", "HP_ABNORMAL_SIZE_OF_PITUITARY_GLAND": "Abnormal size of pituitary gland", "HP_ABNORMAL_SIZE_OF_THE_DENTAL_ROOT": "Abnormal size of the dental root", "HP_ABNORMAL_SPACED_INCISORS": "", "HP_ABNORMAL_SKULL_BASE_MORPHOLOGY": "Abnormal skull base morphology", "HP_ABNORMAL_SPEECH_DISCRIMINATION": "Abnormal speech discrimination", "HP_ABNORMAL_SMALL_INTESTINE_MORPHOLOGY": "Abnormal small intestine morphology", "HP_ABNORMAL_SIZE_OF_THE_PALPEBRAL_FISSURES": "Abnormal size of the palpebral fissures", "HP_ABNORMAL_SOCIAL_BEHAVIOR": "Abnormal social behavior", "HP_ABNORMAL_SOFT_PALATE_MORPHOLOGY": "Abnormal soft palate morphology", "HP_ABNORMAL_SKIN_MORPHOLOGY_OF_THE_PALM": "Abnormal skin morphology of the palm", "HP_ABNORMAL_SKIN_ADNEXA_MORPHOLOGY": "Abnormal skin adnexa morphology", "HP_ABNORMAL_SPERMATOGENESIS": "Abnormal spermatogenesis", "HP_ABNORMAL_SPERM_HEAD_MORPHOLOGY": "Abnormal sperm head morphology", "HP_ABNORMAL_SPERM_AXONEME_MORPHOLOGY": "Abnormal sperm axoneme morphology", "HP_ABNORMAL_SPERM_MOTILITY": "", "HP_ABNORMAL_SPERM_TAIL_MORPHOLOGY": "Abnormal sperm tail morphology", "HP_ABNORMAL_SPINAL_MENINGEAL_MORPHOLOGY": "Abnormal spinal meningeal morphology", "HP_ABNORMAL_SPINAL_CORD_PHYSIOLOGY": "", "HP_ABNORMAL_STERNAL_OSSIFICATION": "Abnormal sternal ossification", "HP_ABNORMAL_SPUTUM": "Abnormal sputum", "HP_ABNORMAL_STOOL_COMPOSITION": "Abnormal stool composition", "HP_ABNORMAL_SPINAL_CORD_MORPHOLOGY": "Abnormal spinal cord morphology", "HP_ABNORMAL_ST_SEGMENT": "Abnormal ST segment", "HP_ABNORMAL_STOMACH_MORPHOLOGY": "Abnormal stomach morphology", "HP_ABNORMAL_STERNUM_MORPHOLOGY": "Abnormal sternum morphology", "HP_ABNORMAL_SUBCLAVIAN_ARTERY_MORPHOLOGY": "Abnormal subclavian artery morphology", "HP_ABNORMAL_SUBCUTANEOUS_FAT_TISSUE_DISTRIBUTION": "Abnormal subcutaneous fat tissue distribution", "HP_ABNORMAL_SUBARACHNOID_SPACE_MORPHOLOGY": "Abnormal subarachnoid space morphology", "HP_ABNORMAL_SUPERIOR_CEREBELLAR_PEDUNCLE_MORPHOLOGY": "Abnormal superior cerebellar peduncle morphology", "HP_ABNORMAL_SUBSTANTIA_NIGRA_MORPHOLOGY": "Abnormal substantia nigra morphology", "HP_ABNORMAL_SWEAT_GLAND_MORPHOLOGY": "Abnormal sweat gland morphology", "HP_ABNORMAL_SWEAT_HOMEOSTASIS": "Abnormal sweat homeostasis", "HP_ABNORMAL_SYNOVIAL_MEMBRANE_MORPHOLOGY": "Abnormal synovial membrane morphology", "HP_ABNORMAL_SYNAPTIC_TRANSMISSION_AT_THE_NEUROMUSCULAR_JUNCTION": "Abnormal synaptic transmission at the neuromuscular junction", "HP_ABNORMAL_TARSAL_OSSIFICATION": "Abnormal tarsal ossification", "HP_ABNORMAL_TALUS_MORPHOLOGY": "Abnormal talus morphology", "HP_ABNORMAL_TEMPORAL_BONE_MORPHOLOGY": "Abnormal temporal bone morphology", "HP_ABNORMAL_TEMPER_TANTRUMS": "Abnormal temper tantrums", "HP_ABNORMAL_SYSTEMIC_ARTERIAL_MORPHOLOGY": "Abnormal systemic arterial morphology", "HP_ABNORMAL_TEMPORAL_LOBE_MORPHOLOGY": "", "HP_ABNORMAL_SYSTEMIC_BLOOD_PRESSURE": "Abnormal systemic blood pressure", "HP_ABNORMAL_THALAMIC_MRI_SIGNAL_INTENSITY": "Abnormal thalamic MRI signal intensity", "HP_ABNORMAL_THIRD_TOE_MORPHOLOGY": "Abnormal third toe morphology", "HP_ABNORMAL_THALAMUS_MORPHOLOGY": "Abnormal thalamus morphology", "HP_ABNORMAL_THIRD_VENTRICLE_MORPHOLOGY": "", "HP_ABNORMAL_TENDON_MORPHOLOGY": "Abnormal tendon morphology", "HP_ABNORMAL_THOUGHT_PATTERN": "", "HP_ABNORMAL_THORACIC_SPINE_MORPHOLOGY": "Abnormal thoracic spine morphology", "HP_ABNORMAL_TESTIS_MORPHOLOGY": "Abnormal testis morphology", "HP_ABNORMAL_THROMBOSIS": "Abnormal thrombosis", "HP_ABNORMAL_THYMUS_MORPHOLOGY": "Abnormal thymus morphology", "HP_ABNORMAL_THUMB_MORPHOLOGY": "Abnormal thumb morphology", "HP_ABNORMAL_THORAX_MORPHOLOGY": "Abnormal thorax morphology", "HP_ABNORMAL_THYROID_MORPHOLOGY": "Abnormal thyroid morphology", "HP_ABNORMAL_TIBIA_MORPHOLOGY": "Abnormal tibia morphology", "HP_ABNORMAL_THYROID_STIMULATING_HORMONE_LEVEL": "Abnormal thyroid-stimulating hormone level", "HP_ABNORMAL_TISSUE_ENZYME_CONCENTRATION_OR_ACTIVITY": "Abnormal tissue enzyme concentration or activity", "HP_ABNORMAL_TOENAIL_MORPHOLOGY": "Abnormal toenail morphology", "HP_ABNORMAL_TISSUE_METABOLITE_CONCENTRATION": "Abnormal tissue metabolite concentration", "HP_ABNORMAL_TOE_PHALANX_MORPHOLOGY": "Abnormal toe phalanx morphology", "HP_ABNORMAL_TRABECULAR_BONE_MORPHOLOGY": "Abnormal trabecular bone morphology", "HP_ABNORMAL_TONGUE_PHYSIOLOGY": "Abnormal tongue physiology", "HP_ABNORMAL_TOE_MORPHOLOGY": "Abnormal toe morphology", "HP_ABNORMAL_TRAGUS_MORPHOLOGY": "Abnormal tragus morphology", "HP_ABNORMAL_TRACHEAL_MORPHOLOGY": "Abnormal tracheal morphology", "HP_ABNORMAL_TONGUE_MORPHOLOGY": "Abnormal tongue morphology", "HP_ABNORMAL_TRANSFERRIN_SATURATION": "Abnormal transferrin saturation", "HP_ABNORMAL_TRACHEOBRONCHIAL_MORPHOLOGY": "Abnormal tracheobronchial morphology", "HP_ABNORMAL_TRICUSPID_VALVE_MORPHOLOGY": "Abnormal tricuspid valve morphology", "HP_ABNORMAL_TRICUSPID_VALVE_PHYSIOLOGY": "Abnormal tricuspid valve physiology", "HP_ABNORMAL_TUBULAR_BASEMENT_MEMBRANE_MORPHOLOGY": "Abnormal tubular basement membrane morphology", "HP_ABNORMAL_T_CELL_ACTIVATION": "", "HP_ABNORMAL_T_CELL_PROLIFERATION": "", "HP_ABNORMAL_T_CELL_MORPHOLOGY": "Abnormal T cell morphology", "HP_ABNORMAL_T_CELL_SUBSET_DISTRIBUTION": "Abnormal T cell subset distribution", "HP_ABNORMAL_UMBILICAL_STUMP_BLEEDING": "Abnormal umbilical stump bleeding", "HP_ABNORMAL_T_WAVE": "Abnormal T-wave", "HP_ABNORMAL_ULNAR_METAPHYSIS_MORPHOLOGY": "Abnormal ulnar metaphysis morphology", "HP_ABNORMAL_UPPER_LIMB_METAPHYSIS_MORPHOLOGY": "Abnormal upper limb metaphysis morphology", "HP_ABNORMAL_UPPER_LIMB_EPIPHYSIS_MORPHOLOGY": "Abnormal upper limb epiphysis morphology", "HP_ABNORMAL_UPPER_MOTOR_NEURON_MORPHOLOGY": "Abnormal upper motor neuron morphology", "HP_ABNORMAL_UPPER_LIMB_BONE_MORPHOLOGY": "Abnormal upper limb bone morphology", "HP_ABNORMAL_UMBILICUS_MORPHOLOGY": "Abnormal umbilicus morphology", "HP_ABNORMAL_URINARY_COLOR": "Abnormal urinary color", "HP_ABNORMAL_URETER_MORPHOLOGY": "Abnormal ureter morphology", "HP_ABNORMAL_URETER_PHYSIOLOGY": "Abnormal ureter physiology", "HP_ABNORMAL_URINARY_ELECTROLYTE_CONCENTRATION": "Abnormal urinary electrolyte concentration", "HP_ABNORMAL_URINARY_NUCLEOBASE_CONCENTRATION": "Abnormal urinary nucleobase concentration", "HP_ABNORMAL_URINARY_ORGANIC_COMPOUND_LEVEL": "Abnormal urinary organic compound level", "HP_ABNORMAL_URINE_ALPHA_KETOGLUTARATE_CONCENTRATION": "Abnormal urine alpha-ketoglutarate concentration", "HP_ABNORMAL_UPPER_LIP_MORPHOLOGY": "Abnormal upper lip morphology", "HP_ABNORMAL_URINARY_PURINE_LEVEL": "Abnormal urinary purine level", "HP_ABNORMAL_URINE_CARBOHYDRATE_LEVEL": "Abnormal urine carbohydrate level", "HP_ABNORMAL_URINE_CARBOXYLIC_ACID_LEVEL": "Abnormal urine carboxylic acid level", "HP_ABNORMAL_URINE_CHLORIDE_CONCENTRATION": "", "HP_ABNORMAL_URINE_MAGNESIUM_CONCENTRATION": "Abnormal urine magnesium concentration", "HP_ABNORMAL_URINE_HORMONE_LEVEL": "Abnormal urine hormone level", "HP_ABNORMAL_URINE_OSMOLALITY": "Abnormal urine osmolality", "HP_ABNORMAL_URINE_POTASSIUM_CONCENTRATION": "Abnormal urine potassium concentration", "HP_ABNORMAL_URINE_PHOSPHATE_CONCENTRATION": "Abnormal urine phosphate concentration", "HP_ABNORMAL_URINE_SODIUM_CONCENTRATION": "Abnormal urine sodium concentration", "HP_ABNORMAL_URINE_METABOLITE_LEVEL": "Abnormal urine metabolite level", "HP_ABNORMAL_URINE_PH": "Abnormal urine pH", "HP_ABNORMAL_UTERINE_CERVIX_MORPHOLOGY": "Abnormal uterine cervix morphology", "HP_ABNORMAL_URINE_PROTEIN_LEVEL": "Abnormal urine protein level", "HP_ABNORMAL_U_WAVE": "Abnormal U wave", "HP_ABNORMAL_UTERUS_MORPHOLOGY": "Abnormal uterus morphology", "HP_ABNORMAL_UVULA_MORPHOLOGY": "Abnormal uvula morphology", "HP_ABNORMAL_UVEA_MORPHOLOGY": "Abnormal uvea morphology", "HP_ABNORMAL_VAGINA_MORPHOLOGY": "Abnormal vagina morphology", "HP_ABNORMAL_VENA_CAVA_MORPHOLOGY": "Abnormal vena cava morphology", "HP_ABNORMAL_VENTRICULAR_AXIS": "Abnormal ventricular axis", "HP_ABNORMAL_VENOUS_MORPHOLOGY": "Abnormal venous morphology", "HP_ABNORMAL_VASCULAR_PHYSIOLOGY": "Abnormal vascular physiology", "HP_ABNORMAL_VERTEBRAL_SEGMENTATION_AND_FUSION": "Abnormal vertebral segmentation and fusion", "HP_ABNORMAL_VASCULAR_MORPHOLOGY": "Abnormal vascular morphology", "HP_ABNORMAL_VESTIBULO_OCULAR_REFLEX": "Abnormal vestibulo-ocular reflex", "HP_ABNORMAL_VENTRICULAR_SEPTUM_MORPHOLOGY": "Abnormal ventricular septum morphology", "HP_ABNORMAL_VESTIBULAR_FUNCTION": "Abnormal vestibular function", "HP_ABNORMAL_VISUAL_ACCOMMODATION": "Abnormal visual accommodation", "HP_ABNORMAL_VERTEBRAL_MORPHOLOGY": "Abnormal vertebral morphology", "HP_ABNORMAL_VISUAL_FIXATION": "Abnormal visual fixation", "HP_ABNORMAL_VISUAL_FIELD_TEST": "Abnormal visual field test", "HP_ABNORMAL_VISUAL_ELECTROPHYSIOLOGY": "Abnormal visual electrophysiology", "HP_ABNORMAL_VITREOUS_HUMOR_MORPHOLOGY": "Abnormal vitreous humor morphology", "HP_ABNORMAL_Z_DISK_MORPHOLOGY": "Abnormal Z disk morphology", "HP_ABNORMAL_VOCAL_CORD_MORPHOLOGY": "Abnormal vocal cord morphology", "HP_ABSENCE_OF_LYMPH_NODE_GERMINAL_CENTER": "Absence of lymph node germinal center", "HP_ABSENCE_OF_RENAL_CORTICOMEDULLARY_DIFFERENTIATION": "Absence of renal corticomedullary differentiation", "HP_ABSENCE_OF_PUBERTAL_DEVELOPMENT": "Absence of pubertal development", "HP_ABSENCE_OF_STOMACH_BUBBLE_ON_FETAL_SONOGRAPHY": "Absence of stomach bubble on fetal sonography", "HP_ABSENCE_OF_SECONDARY_SEX_CHARACTERISTICS": "Absence of secondary sex characteristics", "HP_ABSCESS": "Abscess", "HP_ABSENCE_OF_SUBCUTANEOUS_FAT": "Absence of subcutaneous fat", "HP_ABSENCE_OF_THE_SACRUM": "Absence of the sacrum", "HP_ABNORMAL_ZYGOMATIC_BONE_MORPHOLOGY": "Abnormal zygomatic bone morphology", "HP_ABSENT_AXILLARY_HAIR": "Absent axillary hair", "HP_ABSENT_BRAINSTEM_AUDITORY_RESPONSES": "Absent brainstem auditory responses", "HP_ABSENT_CIRCULATING_B_CELLS": "Absent circulating B cells", "HP_ABSENT_DISTAL_PHALANGES": "", "HP_ABSENT_DISTAL_INTERPHALANGEAL_CREASES": "Absent distal interphalangeal creases", "HP_ABSENT_EARLOBE": "Absent earlobe", "HP_ABSENT_EYEBROW": "Absent eyebrow", "HP_ABSENT_EPIPHYSES": "Absent epiphyses", "HP_ABSENT_FOREARM_BONE": "Absent forearm bone", "HP_ABSENT_FACIAL_HAIR": "Absent facial hair", "HP_ABSENT_FINGERNAIL": "Absent fingernail", "HP_ABSENT_FOVEAL_REFLEX": "Absent foveal reflex", "HP_ABSENT_FRONTAL_SINUSES": "Absent frontal sinuses", "HP_ABSENT_INNER_AND_OUTER_DYNEIN_ARMS": "Absent inner and outer dynein arms", "HP_ABSENT_HAIR": "Absent hair", "HP_ABSENT_HYPOPLASTIC_PARANASAL_SINUSES": "Absent/hypoplastic paranasal sinuses", "HP_ABSENT_HAND": "Absent hand", "HP_ABSENT_INNER_DYNEIN_ARMS": "Absent inner dynein arms", "HP_ABSENT_NIPPLE": "Absent nipple", "HP_ABSENT_LACRIMAL_PUNCTUM": "Absent lacrimal punctum", "HP_ABSENT_OR_MINIMALLY_OSSIFIED_VERTEBRAL_BODIES": "Absent or minimally ossified vertebral bodies", "HP_ABSENT_OUTER_DYNEIN_ARMS": "Absent outer dynein arms", "HP_ABSENT_PALMAR_CREASE": "Absent palmar crease", "HP_ABSENT_PATELLAR_REFLEXES": "Absent patellar reflexes", "HP_ABSENT_PUBIC_HAIR": "Absent pubic hair", "HP_ABSENT_SKIN_PIGMENTATION": "Absent skin pigmentation", "HP_ABSENT_PHALANGEAL_CREASE": "Absent phalangeal crease", "HP_ABSENT_SEPTUM_PELLUCIDUM": "Absent septum pellucidum", "HP_ABSENT_SPERM_FLAGELLA": "Absent sperm flagella", "HP_ABSENT_STERNAL_OSSIFICATION": "Absent sternal ossification", "HP_ABSENT_TESTIS": "Absent testis", "HP_ABSENT_THUMB": "Absent thumb", "HP_ABSENT_THUMBNAIL": "Absent thumbnail", "HP_ABSENT_TIBIA": "Absent tibia", "HP_ABSENT_TOENAIL": "Absent toenail", "HP_ABSENT_TOE": "Absent toe", "HP_ABSENT_VAS_DEFERENS": "Absent vas deferens", "HP_ACANTHOCYTOSIS": "Acanthocytosis", "HP_ABULIA": "Abulia", "HP_ABSENT_SPEECH": "Absent speech", "HP_ACANTHOLYSIS": "Acantholysis", "HP_ACCELERATED_ATHEROSCLEROSIS": "Accelerated atherosclerosis", "HP_ACANTHOSIS_NIGRICANS": "Acanthosis nigricans", "HP_ACCESSORY_ORAL_FRENULUM": "Accessory oral frenulum", "HP_ACCELERATED_SKELETAL_MATURATION": "Accelerated skeletal maturation", "HP_ACCESSORY_SPLEEN": "Accessory spleen", "HP_ACEPHALIC_SPERMATOZOA": "Acephalic spermatozoa", "HP_ACETABULAR_DYSPLASIA": "Acetabular dysplasia", "HP_ACETABULAR_SPURS": "Acetabular spurs", "HP_ACHOLIC_STOOLS": "Acholic stools", "HP_ACHROMATOPSIA": "Achromatopsia", "HP_ACIDEMIA": "Acidemia", "HP_ACNE_INVERSA": "Acne inversa", "HP_ACNE": "Acne", "HP_ACRAL_ULCERATION": "", "HP_ACQUIRED_ABNORMAL_HAIR_PATTERN": "Acquired abnormal hair pattern", "HP_ACRAL_OVERGROWTH": "Acral overgrowth", "HP_ACRAL_BLISTERING": "Acral blistering", "HP_ACROMICRIA": "Acromicria", "HP_ACROMESOMELIA": "Acromesomelia", "HP_ACROPARESTHESIA": "Acroparesthesia", "HP_ACUTE_ENCEPHALOPATHY": "Acute encephalopathy", "HP_ACTION_TREMOR": "Action tremor", "HP_ACUTE_CORONARY_SYNDROME": "Acute coronary syndrome", "HP_ACUTE_INFECTIOUS_PNEUMONIA": "Acute infectious pneumonia", "HP_ACUTE_HEPATIC_FAILURE": "Acute hepatic failure", "HP_ACUTE_LEUKEMIA": "Acute leukemia", "HP_ACUTE_OTITIS_MEDIA": "Acute otitis media", "HP_ACUTE_KIDNEY_INJURY": "Acute kidney injury", "HP_ACUTE_MYELOID_LEUKEMIA": "Acute myeloid leukemia", "HP_ACUTE_LYMPHOBLASTIC_LEUKEMIA": "Acute lymphoblastic leukemia", "HP_ACUTE_PANCREATITIS": "Acute pancreatitis", "HP_ACUTE_RHABDOMYOLYSIS": "Acute rhabdomyolysis", "HP_ADDICTIVE_BEHAVIOR": "", "HP_ACUTE_PHASE_RESPONSE": "Acute phase response", "HP_ADDUCTED_THUMB": "Adducted thumb", "HP_ADENOCARCINOMA_OF_THE_COLON": "Adenocarcinoma of the colon", "HP_ADENOCARCINOMA_OF_THE_INTESTINES": "Adenocarcinoma of the intestines", "HP_ADENOMATOUS_COLONIC_POLYPOSIS": "Adenomatous colonic polyposis", "HP_ADENOCARCINOMA_OF_THE_SMALL_INTESTINE": "Adenocarcinoma of the small intestine", "HP_ADENOMA_SEBACEUM": "Adenoma sebaceum", "HP_ADIPOSE_TISSUE_LOSS": "Adipose tissue loss", "HP_ADRENAL_HYPERPLASIA": "Adrenal hyperplasia", "HP_ADRENAL_OVERACTIVITY": "Adrenal overactivity", "HP_ADRENAL_HYPOPLASIA": "Adrenal hypoplasia", "HP_ADRENAL_INSUFFICIENCY": "Adrenal insufficiency", "HP_ADRENOCORTICAL_ABNORMALITY": "Adrenocortical abnormality", "HP_ADRENOCORTICAL_ADENOMA": "Adrenocortical adenoma", "HP_ADRENOCORTICOTROPIC_HORMONE_DEFICIENCY": "Adrenocorticotropic hormone deficiency", "HP_ADRENOCORTICAL_CARCINOMA": "Adrenocortical carcinoma", "HP_ADRENOCORTICOTROPIC_HORMONE_EXCESS": "Adrenocorticotropic hormone excess", "HP_ADRENOCORTICOTROPIN_DEFICIENT_ADRENAL_INSUFFICIENCY": "Adrenocorticotropin deficient adrenal insufficiency", "HP_ADULT_ONSET_SENSORINEURAL_HEARING_IMPAIRMENT": "Adult onset sensorineural hearing impairment", "HP_ADVANCED_OSSIFICATION_OF_CARPAL_BONES": "Advanced ossification of carpal bones", "HP_ADVANCED_ERUPTION_OF_TEETH": "Advanced eruption of teeth", "HP_ADULT_ONSET": "Adult onset", "HP_AGENESIS_OF_CEREBELLAR_VERMIS": "Agenesis of cerebellar vermis", "HP_AGENESIS_OF_CENTRAL_INCISOR": "Agenesis of central incisor", "HP_AGENESIS_OF_INCISOR": "Agenesis of incisor", "HP_AGAMMAGLOBULINEMIA": "Agammaglobulinemia", "HP_AGENESIS_OF_MAXILLARY_INCISOR": "Agenesis of maxillary incisor", "HP_AGENESIS_OF_LATERAL_INCISOR": "Agenesis of lateral incisor", "HP_AGANGLIONIC_MEGACOLON": "Aganglionic megacolon", "HP_AGENESIS_OF_PERMANENT_TEETH": "Agenesis of permanent teeth", "HP_AGENESIS_OF_CORPUS_CALLOSUM": "Agenesis of corpus callosum", "HP_AGYRIA": "Agyria", "HP_AGITATION": "Agitation", "HP_AIRWAY_HYPERRESPONSIVENESS": "Airway hyperresponsiveness", "HP_ALACRIMA": "Alacrima", "HP_ALBINISM": "Albinism", "HP_AIRWAY_OBSTRUCTION": "Airway obstruction", "HP_AGGRESSIVE_BEHAVIOR": "Aggressive behavior", "HP_AKINESIA": "Akinesia", "HP_ALEXIA": "Alexia", "HP_ALBUMINURIA": "Albuminuria", "HP_ALKALOSIS": "Alkalosis", "HP_ALLERGIC_RHINITIS": "Allergic rhinitis", "HP_ALLERGY": "Allergy", "HP_ALOBAR_HOLOPROSENCEPHALY": "Alobar holoprosencephaly", "HP_ALOPECIA_TOTALIS": "Alopecia totalis", "HP_ALOPECIA_OF_SCALP": "Alopecia of scalp", "HP_ALTERNATING_ESOTROPIA": "Alternating esotropia", "HP_ALVEOLAR_RHABDOMYOSARCOMA": "Alveolar rhabdomyosarcoma", "HP_ALVEOLAR_CELL_CARCINOMA": "Alveolar cell carcinoma", "HP_ALOPECIA_UNIVERSALIS": "Alopecia universalis", "HP_ALOPECIA": "Alopecia", "HP_ALVEOLAR_RIDGE_OVERGROWTH": "Alveolar ridge overgrowth", "HP_ALZHEIMER_DISEASE": "Alzheimer disease", "HP_AMAUROSIS_FUGAX": "Amaurosis fugax", "HP_AMBIGUOUS_GENITALIA_FEMALE": "Ambiguous genitalia, female", "HP_AMBIGUOUS_GENITALIA": "Ambiguous genitalia", "HP_AMEGAKARYOCYTIC_THROMBOCYTOPENIA": "Amegakaryocytic thrombocytopenia", "HP_AMBIGUOUS_GENITALIA_MALE": "Ambiguous genitalia, male", "HP_AMNIOTIC_CONSTRICTION_RING": "Amniotic constriction ring", "HP_AMBLYOPIA": "Amblyopia", "HP_AMELOGENESIS_IMPERFECTA": "Amelogenesis imperfecta", "HP_ANAL_ATRESIA": "Anal atresia", "HP_AMINOACIDURIA": "Aminoaciduria", "HP_AMENORRHEA": "Amenorrhea", "HP_AMYLOIDOSIS": "", "HP_AMYOTROPHIC_LATERAL_SCLEROSIS": "Amyotrophic lateral sclerosis", "HP_ANAL_FISTULA": "Anal fistula", "HP_ANAL_FISSURE": "", "HP_ANAPHYLACTIC_SHOCK": "Anaphylactic shock", "HP_ANAL_STENOSIS": "Anal stenosis", "HP_ANARTHRIA": "Anarthria", "HP_ANASARCA": "Anasarca", "HP_ANDROGEN_INSUFFICIENCY": "Androgen insufficiency", "HP_ANEMIC_PALLOR": "Anemic pallor", "HP_ANENCEPHALY": "Anencephaly", "HP_ANGINA_PECTORIS": "Angina pectoris", "HP_ANEMIA_OF_INADEQUATE_PRODUCTION": "Anemia of inadequate production", "HP_ANEMIA_DUE_TO_REDUCED_LIFE_SPAN_OF_RED_CELLS": "Anemia due to reduced life span of red cells", "HP_ANGIOEDEMA": "Angioedema", "HP_ANGIOFIBROMAS": "Angiofibromas", "HP_ANGIOID_STREAKS_OF_THE_FUNDUS": "", "HP_ANGIOKERATOMA": "Angiokeratoma", "HP_ANGIOSARCOMA": "", "HP_ANGLE_CLOSURE_GLAUCOMA": "Angle closure glaucoma", "HP_ANGULAR_CHEILITIS": "Angular cheilitis", "HP_ANHIDROSIS": "Anhidrosis", "HP_ANGULATED_MUSCLE_FIBERS": "Angulated muscle fibers", "HP_ANHYDRAMNIOS": "Anhydramnios", "HP_ANISOCYTOSIS": "Anisocytosis", "HP_ANISOCORIA": "Anisocoria", "HP_ANIRIDIA": "Aniridia", "HP_ANISOPOIKILOCYTOSIS": "Anisopoikilocytosis", "HP_ANISOMETROPIA": "Anisometropia", "HP_ANKLE_PAIN": "Ankle pain", "HP_ANKLE_CONTRACTURE": "Ankle contracture", "HP_ANKLE_CLONUS": "Ankle clonus", "HP_ANKLE_SWELLING": "Ankle swelling", "HP_ANKLE_WEAKNESS": "Ankle weakness", "HP_ANKYLOSIS": "Ankylosis", "HP_ANKYLOBLEPHARON": "Ankyloblepharon", "HP_ANODONTIA": "Anodontia", "HP_ANKYLOGLOSSIA": "Ankyloglossia", "HP_ANNULAR_PANCREAS": "Annular pancreas", "HP_ANOMIC_APHASIA": "Anomic aphasia", "HP_ANOMALOUS_TRICHROMACY": "Anomalous trichromacy", "HP_ANOPHTHALMIA": "Anophthalmia", "HP_ANONYCHIA": "Anonychia", "HP_ANOTIA": "Anotia", "HP_ANTECUBITAL_PTERYGIUM": "Antecubital pterygium", "HP_ANOREXIA": "Anorexia", "HP_ANTALGIC_GAIT": "Antalgic gait", "HP_ANOSMIA": "Anosmia", "HP_ANORECTAL_ANOMALY": "Anorectal anomaly", "HP_ANTERIORLY_PLACED_ANUS": "Anteriorly placed anus", "HP_ANTERIOR_BEAKING_OF_LUMBAR_VERTEBRAE": "Anterior beaking of lumbar vertebrae", "HP_ANTENATAL_ONSET": "Antenatal onset", "HP_ANTERIOR_CHAMBER_SYNECHIAE": "Anterior chamber synechiae", "HP_ANTERIOR_OPEN_BITE_MALOCCLUSION": "Anterior open-bite malocclusion", "HP_ANTERIOR_CREASES_OF_EARLOBE": "Anterior creases of earlobe", "HP_ANTERIOR_PITUITARY_HYPOPLASIA": "Anterior pituitary hypoplasia", "HP_ANTERIOR_POLAR_CATARACT": "Anterior polar cataract", "HP_ANTERIOR_PITUITARY_AGENESIS": "Anterior pituitary agenesis", "HP_ANTERIOR_PLAGIOCEPHALY": "Anterior plagiocephaly", "HP_ANTERIOR_RIB_CUPPING": "Anterior rib cupping", "HP_ANTERIOR_UVEITIS": "Anterior uveitis", "HP_ANTERIOR_SUBCAPSULAR_CATARACT": "Anterior subcapsular cataract", "HP_ANTERIOR_SYNECHIAE_OF_THE_ANTERIOR_CHAMBER": "Anterior synechiae of the anterior chamber", "HP_ANTEVERTED_EARS": "Anteverted ears", "HP_ANTIMITOCHONDRIAL_ANTIBODY_POSITIVITY": "Antimitochondrial antibody positivity", "HP_ANTIPHOSPHOLIPID_ANTIBODY_POSITIVITY": "Antiphospholipid antibody positivity", "HP_ANTI_ACETYLCHOLINE_RECEPTOR_ANTIBODY_POSITIVITY": "Anti-acetylcholine receptor antibody positivity", "HP_ANTINUCLEAR_ANTIBODY_POSITIVITY": "Antinuclear antibody positivity", "HP_ANTINEUTROPHIL_ANTIBODY_POSITIVITY": "Antineutrophil antibody positivity", "HP_ANTI_THYROGLOBULIN_ANTIBODY_POSITIVITY": "Anti-thyroglobulin antibody positivity", "HP_ANTI_SMOOTH_MUSCLE_ANTIBODY_POSITIVITY": "Anti-smooth muscle antibody positivity", "HP_ANTI_THYROID_ANTIBODY_POSITIVITY": "Anti-thyroid antibody positivity", "HP_ANURIA": "Anuria", "HP_AORTIC_ARCH_ANEURYSM": "Aortic arch aneurysm", "HP_AORTIC_ATHEROSCLEROTIC_LESION": "Aortic atherosclerotic lesion", "HP_AORTIC_ANEURYSM": "Aortic aneurysm", "HP_AORTIC_DISSECTION": "Aortic dissection", "HP_AORTIC_ROOT_ANEURYSM": "Aortic root aneurysm", "HP_AORTIC_VALVE_CALCIFICATION": "Aortic valve calcification", "HP_AORTIC_REGURGITATION": "Aortic regurgitation", "HP_AORTIC_TORTUOSITY": "Aortic tortuosity", "HP_AORTOPULMONARY_COLLATERAL_ARTERIES": "Aortopulmonary collateral arteries", "HP_AORTIC_VALVE_STENOSIS": "Aortic valve stenosis", "HP_APHASIA": "Aphasia", "HP_APHTHOUS_ULCER": "Aphthous ulcer", "HP_APATHY": "Apathy", "HP_APLASIA_CUTIS_CONGENITA": "Aplasia cutis congenita", "HP_APLASIA_CUTIS_CONGENITA_OVER_THE_SCALP_VERTEX": "Aplasia cutis congenita over the scalp vertex", "HP_APLASIA_CUTIS_CONGENITA_ON_TRUNK_OR_LIMBS": "Aplasia cutis congenita on trunk or limbs", "HP_APLASIA_CUTIS_CONGENITA_OF_SCALP": "Aplasia cutis congenita of scalp", "HP_APLASIA_HYPOPLASIA_AFFECTING_THE_ANTERIOR_SEGMENT_OF_THE_EYE": "Aplasia/Hypoplasia affecting the anterior segment of the eye", "HP_APLASIA_HYPOPLASIA_AFFECTING_THE_EYE": "Aplasia/Hypoplasia affecting the eye", "HP_APLASIA_HYPOPLASIA_AFFECTING_BONES_OF_THE_AXIAL_SKELETON": "Aplasia/hypoplasia affecting bones of the axial skeleton", "HP_APLASIA_HYPOPLASIA_AFFECTING_THE_FUNDUS": "Aplasia/Hypoplasia affecting the fundus", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_CARPAL_BONES": "Aplasia/Hypoplasia involving the carpal bones", "HP_APLASIA_HYPOPLASIA_INVOLVING_BONES_OF_THE_THORAX": "Aplasia/Hypoplasia involving bones of the thorax", "HP_APLASIA_HYPOPLASIA_INVOLVING_BONES_OF_THE_FEET": "Aplasia/Hypoplasia involving bones of the feet", "HP_APLASIA_HYPOPLASIA_INVOLVING_BONES_OF_THE_LOWER_LIMBS": "Aplasia/hypoplasia involving bones of the lower limbs", "HP_APLASIA_HYPOPLASIA_INVOLVING_FOREARM_BONES": "Aplasia/hypoplasia involving forearm bones", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_CORTICOSPINAL_TRACTS": "", "HP_APLASIA_HYPOPLASIA_INVOLVING_BONES_OF_THE_UPPER_LIMBS": "Aplasia/hypoplasia involving bones of the upper limbs", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_FEMORAL_HEAD_AND_NECK": "Aplasia/Hypoplasia involving the femoral head and neck", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_METACARPAL_BONES": "Aplasia/Hypoplasia involving the metacarpal bones", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_MUSCULATURE_OF_THE_EXTREMITIES": "Aplasia/Hypoplasia involving the musculature of the extremities", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_NOSE": "Aplasia/Hypoplasia involving the nose", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_SHOULDER_MUSCULATURE": "", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_SINUSES": "Aplasia/Hypoplasia involving the sinuses", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_PELVIS": "Aplasia/Hypoplasia involving the pelvis", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_SKELETAL_MUSCULATURE": "Aplasia/Hypoplasia involving the skeletal musculature", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_VERTEBRAL_COLUMN": "Aplasia/Hypoplasia involving the vertebral column", "HP_APLASIA_HYPOPLASIA_OF_THE_1ST_METACARPAL": "", "HP_APLASIA_HYPOPLASIA_OF_FACIAL_BONES": "Aplasia/Hypoplasia of facial bones", "HP_APLASIA_HYPOPLASIA_OF_THE_2ND_METACARPAL": "Aplasia/Hypoplasia of the 2nd metacarpal", "HP_APLASIA_HYPOPLASIA_OF_THE_2ND_FINGER": "Aplasia/Hypoplasia of the 2nd finger", "HP_APLASIA_HYPOPLASIA_OF_METATARSAL_BONES": "Aplasia/Hypoplasia of metatarsal bones", "HP_APLASIA_HYPOPLASIA_OF_THE_3RD_FINGER": "Aplasia/Hypoplasia of the 3rd finger", "HP_APLASIA_HYPOPLASIA_OF_THE_3RD_METACARPAL": "Aplasia/Hypoplasia of the 3rd metacarpal", "HP_APLASIA_HYPOPLASIA_INVOLVING_THE_SKELETON": "Aplasia/hypoplasia involving the skeleton", "HP_APLASIA_HYPOPLASIA_OF_FINGERS": "Aplasia/Hypoplasia of fingers", "HP_APLASIA_HYPOPLASIA_OF_THE_4TH_FINGER": "Aplasia/Hypoplasia of the 4th finger", "HP_APLASIA_HYPOPLASIA_OF_THE_5TH_FINGER": "Aplasia/Hypoplasia of the 5th finger", "HP_APLASIA_HYPOPLASIA_OF_THE_5TH_METACARPAL": "Aplasia/Hypoplasia of the 5th metacarpal", "HP_APLASIA_HYPOPLASIA_OF_THE_BLADDER": "Aplasia/Hypoplasia of the bladder", "HP_APLASIA_HYPOPLASIA_OF_THE_ABDOMINAL_WALL_MUSCULATURE": "Aplasia/Hypoplasia of the abdominal wall musculature", "HP_APLASIA_HYPOPLASIA_OF_THE_CAPITAL_FEMORAL_EPIPHYSIS": "Aplasia/Hypoplasia of the capital femoral epiphysis", "HP_APLASIA_HYPOPLASIA_OF_THE_BREASTS": "Aplasia/Hypoplasia of the breasts", "HP_APLASIA_HYPOPLASIA_OF_THE_BRAINSTEM": "Aplasia/Hypoplasia of the brainstem", "HP_APLASIA_HYPOPLASIA_OF_THE_CEREBRAL_WHITE_MATTER": "Aplasia/Hypoplasia of the cerebral white matter", "HP_APLASIA_HYPOPLASIA_OF_THE_CEREBELLAR_VERMIS": "Aplasia/Hypoplasia of the cerebellar vermis", "HP_APLASIA_HYPOPLASIA_OF_THE_COLON": "Aplasia/Hypoplasia of the colon", "HP_APLASIA_HYPOPLASIA_OF_THE_DIAPHRAGM": "Aplasia/Hypoplasia of the diaphragm", "HP_APLASIA_HYPOPLASIA_OF_THE_CEREBELLUM": "Aplasia/Hypoplasia of the cerebellum", "HP_APLASIA_HYPOPLASIA_OF_THE_CLAVICLES": "Aplasia/Hypoplasia of the clavicles", "HP_APLASIA_HYPOPLASIA_OF_THE_DISTAL_PHALANGES_OF_THE_TOES": "Aplasia/Hypoplasia of the distal phalanges of the toes", "HP_APLASIA_HYPOPLASIA_OF_THE_DISTAL_PHALANGES_OF_THE_HAND": "", "HP_APLASIA_HYPOPLASIA_OF_THE_DISTAL_PHALANX_OF_THE_HALLUX": "Aplasia/Hypoplasia of the distal phalanx of the hallux", "HP_APLASIA_HYPOPLASIA_OF_THE_DISTAL_PHALANX_OF_THE_5TH_FINGER": "", "HP_APLASIA_HYPOPLASIA_OF_THE_CORPUS_CALLOSUM": "Aplasia/Hypoplasia of the corpus callosum", "HP_APLASIA_HYPOPLASIA_OF_THE_DISTAL_PHALANX_OF_THE_THUMB": "", "HP_APLASIA_HYPOPLASIA_OF_THE_EPIGLOTTIS": "Aplasia/Hypoplasia of the Epiglottis", "HP_APLASIA_HYPOPLASIA_OF_THE_EAR": "Aplasia/Hypoplasia of the ear", "HP_APLASIA_HYPOPLASIA_OF_THE_EARLOBES": "Aplasia/Hypoplasia of the earlobes", "HP_APLASIA_HYPOPLASIA_OF_THE_FALLOPIAN_TUBE": "Aplasia/Hypoplasia of the fallopian tube", "HP_APLASIA_HYPOPLASIA_OF_THE_EYELID": "Aplasia/Hypoplasia of the eyelid", "HP_APLASIA_HYPOPLASIA_OF_THE_EYEBROW": "Aplasia/Hypoplasia of the eyebrow", "HP_APLASIA_HYPOPLASIA_OF_THE_FIBULA": "Aplasia/Hypoplasia of the fibula", "HP_APLASIA_HYPOPLASIA_OF_THE_FEMUR": "Aplasia/hypoplasia of the femur", "HP_APLASIA_HYPOPLASIA_OF_THE_EXTREMITIES": "Aplasia/hypoplasia of the extremities", "HP_APLASIA_HYPOPLASIA_OF_THE_GALLBLADDER": "", "HP_APLASIA_HYPOPLASIA_OF_THE_INNER_EAR": "Aplasia/Hypoplasia of the inner ear", "HP_APLASIA_HYPOPLASIA_OF_THE_HALLUX": "Aplasia/Hypoplasia of the hallux", "HP_APLASIA_HYPOPLASIA_OF_THE_LENS": "Aplasia/Hypoplasia of the lens", "HP_APLASIA_HYPOPLASIA_OF_THE_HUMERUS": "Aplasia/hypoplasia of the humerus", "HP_APLASIA_HYPOPLASIA_OF_THE_MIDDLE_PHALANGES_OF_THE_TOES": "Aplasia/Hypoplasia of the middle phalanges of the toes", "HP_APLASIA_HYPOPLASIA_OF_THE_LUNGS": "Aplasia/Hypoplasia of the lungs", "HP_APLASIA_HYPOPLASIA_OF_THE_MUSCULATURE_OF_THE_PELVIS": "", "HP_APLASIA_HYPOPLASIA_OF_THE_MIDDLE_PHALANGES_OF_THE_HAND": "Aplasia/Hypoplasia of the middle phalanges of the hand", "HP_APLASIA_HYPOPLASIA_OF_THE_MIDDLE_PHALANX_OF_THE_5TH_FINGER": "Aplasia/Hypoplasia of the middle phalanx of the 5th finger", "HP_APLASIA_HYPOPLASIA_OF_THE_NASAL_BONE": "Aplasia/Hypoplasia of the nasal bone", "HP_APLASIA_HYPOPLASIA_OF_THE_NASAL_SEPTUM": "Aplasia/Hypoplasia of the nasal septum", "HP_APLASIA_HYPOPLASIA_OF_THE_NAILS": "Aplasia/Hypoplasia of the nails", "HP_APLASIA_HYPOPLASIA_OF_THE_NIPPLES": "Aplasia/Hypoplasia of the nipples", "HP_APLASIA_HYPOPLASIA_OF_THE_OPTIC_NERVE": "Aplasia/Hypoplasia of the optic nerve", "HP_APLASIA_HYPOPLASIA_OF_THE_OVARY": "Aplasia/Hypoplasia of the ovary", "HP_APLASIA_HYPOPLASIA_OF_THE_PATELLA": "Aplasia/Hypoplasia of the patella", "HP_APLASIA_HYPOPLASIA_OF_THE_PHALANGES_OF_THE_5TH_TOE": "Aplasia/Hypoplasia of the phalanges of the 5th toe", "HP_APLASIA_HYPOPLASIA_OF_THE_PALMAR_CREASES": "Aplasia/Hypoplasia of the palmar creases", "HP_APLASIA_HYPOPLASIA_OF_THE_PHALANGES_OF_THE_5TH_FINGER": "Aplasia/Hypoplasia of the phalanges of the 5th finger", "HP_APLASIA_HYPOPLASIA_OF_THE_PHALANGES_OF_THE_HALLUX": "Aplasia/Hypoplasia of the phalanges of the hallux", "HP_APLASIA_HYPOPLASIA_OF_THE_PHALANGES_OF_THE_THUMB": "Aplasia/Hypoplasia of the phalanges of the thumb", "HP_APLASIA_HYPOPLASIA_OF_THE_PHALANGES_OF_THE_HAND": "Aplasia/Hypoplasia of the phalanges of the hand", "HP_APLASIA_HYPOPLASIA_OF_THE_PHALANGES_OF_THE_TOES": "Aplasia/Hypoplasia of the phalanges of the toes", "HP_APLASIA_HYPOPLASIA_OF_THE_PROXIMAL_PHALANGES_OF_THE_HAND": "Aplasia/Hypoplasia of the proximal phalanges of the hand", "HP_APLASIA_HYPOPLASIA_OF_THE_PUBIC_BONE": "Aplasia/Hypoplasia of the pubic bone", "HP_APLASIA_HYPOPLASIA_OF_THE_RETINA": "Aplasia/Hypoplasia of the retina", "HP_APLASIA_HYPOPLASIA_OF_THE_RADIUS": "Aplasia/Hypoplasia of the radius", "HP_APLASIA_HYPOPLASIA_OF_THE_SACRUM": "Aplasia/Hypoplasia of the sacrum", "HP_APLASIA_HYPOPLASIA_OF_THE_SCAPULAE": "Aplasia/Hypoplasia of the scapulae", "HP_APLASIA_HYPOPLASIA_OF_THE_RIBS": "Aplasia/Hypoplasia of the ribs", "HP_APLASIA_HYPOPLASIA_OF_THE_STERNUM": "Aplasia/Hypoplasia of the sternum", "HP_APLASIA_HYPOPLASIA_OF_THE_SWEAT_GLANDS": "Aplasia/Hypoplasia of the sweat glands", "HP_APLASIA_HYPOPLASIA_OF_THE_SPLEEN": "Aplasia/Hypoplasia of the spleen", "HP_APLASIA_HYPOPLASIA_OF_THE_SKIN": "Aplasia/Hypoplasia of the skin", "HP_APLASIA_HYPOPLASIA_OF_THE_THUMB": "Aplasia/Hypoplasia of the thumb", "HP_APLASIA_HYPOPLASIA_OF_THE_THYMUS": "Aplasia/Hypoplasia of the thymus", "HP_APLASIA_HYPOPLASIA_OF_THE_THYROID_GLAND": "Aplasia/Hypoplasia of the thyroid gland", "HP_APLASIA_HYPOPLASIA_OF_THE_TRAGUS": "Aplasia/Hypoplasia of the tragus", "HP_APLASIA_HYPOPLASIA_OF_THE_TIBIA": "Aplasia/Hypoplasia of the tibia", "HP_APLASIA_HYPOPLASIA_OF_THE_TONGUE": "Aplasia/Hypoplasia of the tongue", "HP_APLASIA_HYPOPLASIA_OF_THE_UVULA": "Aplasia/Hypoplasia of the uvula", "HP_APLASIA_HYPOPLASIA_OF_THE_ULNA": "Aplasia/Hypoplasia of the ulna", "HP_APLASIA_HYPOPLASIA_OF_THE_UTERUS": "Aplasia/hypoplasia of the uterus", "HP_APLASIA_INVOLVING_BONES_OF_THE_EXTREMITIES": "Aplasia involving bones of the extremities", "HP_APLASIA_HYPOPLASIA_OF_THE_VAGINA": "Aplasia/Hypoplasia of the vagina", "HP_APLASIA_HYPOPLASIA_OF_THE_VERTEBRAE": "Aplasia/Hypoplasia of the vertebrae", "HP_APLASIA_HYPOPLASIA_OF_TOE": "Aplasia/Hypoplasia of toe", "HP_APLASIA_INVOLVING_BONES_OF_THE_LOWER_LIMBS": "Aplasia involving bones of the lower limbs", "HP_APLASIA_INVOLVING_BONES_OF_THE_UPPER_LIMBS": "Aplasia involving bones of the upper limbs", "HP_APLASIA_OF_METACARPAL_BONES": "Aplasia of metacarpal bones", "HP_APLASIA_OF_THE_BLADDER": "Aplasia of the bladder", "HP_APLASIA_OF_THE_2ND_FINGER": "Aplasia of the 2nd finger", "HP_APLASIA_OF_THE_DISTAL_PHALANGES_OF_THE_TOES": "Aplasia of the distal phalanges of the toes", "HP_APLASIA_OF_THE_LEFT_HEMIDIAPHRAGM": "Aplasia of the left hemidiaphragm", "HP_APLASIA_OF_THE_NASAL_BONE": "Aplasia of the nasal bone", "HP_APLASIA_OF_THE_MIDDLE_PHALANX_OF_THE_HAND": "Aplasia of the middle phalanx of the hand", "HP_APLASIA_OF_THE_MUSCULATURE": "Aplasia of the musculature", "HP_APLASIA_OF_THE_OVARY": "Aplasia of the ovary", "HP_APLASIA_OF_THE_OLFACTORY_BULB": "Aplasia of the olfactory bulb", "HP_APLASIA_OF_THE_PECTORALIS_MAJOR_MUSCLE": "Aplasia of the pectoralis major muscle", "HP_APLASIA_OF_THE_SEMICIRCULAR_CANAL": "Aplasia of the semicircular canal", "HP_APLASIA_OF_THE_PROXIMAL_PHALANGES_OF_THE_HAND": "Aplasia of the proximal phalanges of the hand", "HP_APLASIA_OF_THE_PHALANGES_OF_THE_TOES": "Aplasia of the phalanges of the toes", "HP_APLASIA_OF_THE_ULNA": "Aplasia of the ulna", "HP_APLASIA_OF_THE_UTERUS": "Aplasia of the uterus", "HP_APLASTIC_CLAVICLE": "Aplastic clavicle", "HP_APLASTIC_ANEMIA": "Aplastic anemia", "HP_APLASTIC_HYPOPLASTIC_LACRIMAL_GLANDS": "Aplastic/hypoplastic lacrimal glands", "HP_APLASTIC_HYPOPLASTIC_TOENAIL": "Aplastic/hypoplastic toenail", "HP_APNEIC_EPISODES_IN_INFANCY": "Apneic episodes in infancy", "HP_APPENDICULAR_HYPOTONIA": "Appendicular hypotonia", "HP_APNEIC_EPISODES_PRECIPITATED_BY_ILLNESS_FATIGUE_STRESS": "Apneic episodes precipitated by illness, fatigue, stress", "HP_APNEA": "Apnea", "HP_ARACHNODACTYLY": "Arachnodactyly", "HP_AQUEDUCTAL_STENOSIS": "Aqueductal stenosis", "HP_ARACHNOID_HEMANGIOMATOSIS": "Arachnoid hemangiomatosis", "HP_APPENDICULAR_SPASTICITY": "Appendicular spasticity", "HP_APRAXIA": "Apraxia", "HP_AREFLEXIA_OF_UPPER_LIMBS": "Areflexia of upper limbs", "HP_ARM_DYSTONIA": "Arm dystonia", "HP_AREFLEXIA_OF_LOWER_LIMBS": "Areflexia of lower limbs", "HP_ARRHINENCEPHALY": "Arrhinencephaly", "HP_AREFLEXIA": "Areflexia", "HP_ARTERIAL_RUPTURE": "Arterial rupture", "HP_ARTERIAL_THROMBOSIS": "Arterial thrombosis", "HP_ARTERIAL_DISSECTION": "Arterial dissection", "HP_ARTERIAL_STENOSIS": "Arterial stenosis", "HP_ARTERIA_LUSORIA": "", "HP_ARTERIOSCLEROSIS": "Arteriosclerosis", "HP_ARTHRALGIA_OF_THE_HIP": "Arthralgia of the hip", "HP_ARTERIOVENOUS_FISTULA": "Arteriovenous fistula", "HP_ARTERIOVENOUS_MALFORMATION": "Arteriovenous malformation", "HP_ARTHRALGIA": "Arthralgia", "HP_ARTHRITIS": "Arthritis", "HP_ARTHROGRYPOSIS_MULTIPLEX_CONGENITA": "Arthrogryposis multiplex congenita", "HP_ARTHROPATHY": "Arthropathy", "HP_ASCENDING_TUBULAR_AORTA_ANEURYSM": "Ascending tubular aorta aneurysm", "HP_ASPIRATION": "Aspiration", "HP_ASTERIXIS": "Asterixis", "HP_ASCITES": "Ascites", "HP_ASTHENIA": "Asthenia", "HP_ASPIRATION_PNEUMONIA": "Aspiration pneumonia", "HP_ASTROCYTOSIS": "Astrocytosis", "HP_ASTHMA": "Asthma", "HP_ASTROCYTOMA": "Astrocytoma", "HP_ASYMMETRIC_GROWTH": "Asymmetric growth", "HP_ASTIGMATISM": "Astigmatism", "HP_ASYMMETRY_OF_SPINAL_FACET_JOINTS": "Asymmetry of spinal facet joints", "HP_ASYMMETRIC_SEPTAL_HYPERTROPHY": "Asymmetric septal hypertrophy", "HP_ASYMMETRY_OF_THE_EARS": "Asymmetry of the ears", "HP_ASYMMETRY_OF_THE_THORAX": "Asymmetry of the thorax", "HP_ATELECTASIS": "Atelectasis", "HP_ATLANTOAXIAL_ABNORMALITY": "Atlantoaxial abnormality", "HP_ATLANTOAXIAL_DISLOCATION": "Atlantoaxial dislocation", "HP_ATHETOSIS": "Athetosis", "HP_ATLANTOAXIAL_INSTABILITY": "Atlantoaxial instability", "HP_ATONIC_SEIZURE": "Atonic seizure", "HP_ATRIAL_FLUTTER": "Atrial flutter", "HP_ATRESIA_OF_THE_EXTERNAL_AUDITORY_CANAL": "Atresia of the external auditory canal", "HP_ATOPIC_DERMATITIS": "Atopic dermatitis", "HP_ATRIAL_FIBRILLATION": "Atrial fibrillation", "HP_ATRIAL_STANDSTILL": "Atrial standstill", "HP_ATROPHIC_GASTRITIS": "Atrophic gastritis", "HP_ATRIOVENTRICULAR_CANAL_DEFECT": "Atrioventricular canal defect", "HP_ATROPHIC_SCARS": "Atrophic scars", "HP_ATROPHY_DEGENERATION_AFFECTING_THE_BRAINSTEM": "Atrophy/Degeneration affecting the brainstem", "HP_ATROPHY_DEGENERATION_INVOLVING_THE_CAUDATE_NUCLEUS": "Atrophy/Degeneration involving the caudate nucleus", "HP_ATROPHY_DEGENERATION_INVOLVING_THE_SPINAL_CORD": "Atrophy/Degeneration involving the spinal cord", "HP_ATROPHY_OF_ALVEOLAR_RIDGES": "Atrophy of alveolar ridges", "HP_ATROPHY_DEGENERATION_INVOLVING_THE_CORTICOSPINAL_TRACTS": "Atrophy/Degeneration involving the corticospinal tracts", "HP_ATTACHED_EARLOBE": "Attached earlobe", "HP_ATROPHY_DEGENERATION_AFFECTING_THE_CENTRAL_NERVOUS_SYSTEM": "Atrophy/Degeneration affecting the central nervous system", "HP_ATTENUATION_OF_RETINAL_BLOOD_VESSELS": "Attenuation of retinal blood vessels", "HP_ATYPICAL_NEVI_IN_NON_SUN_EXPOSED_AREAS": "Atypical nevi in non-sun exposed areas", "HP_ATYPICAL_ABSENCE_SEIZURE": "Atypical absence seizure", "HP_ATROPHY_DEGENERATION_AFFECTING_THE_CEREBRUM": "Atrophy/Degeneration affecting the cerebrum", "HP_ATTENTION_DEFICIT_HYPERACTIVITY_DISORDER": "Attention deficit hyperactivity disorder", "HP_AUDITORY_HALLUCINATION": "Auditory hallucination", "HP_ATYPICAL_SCARRING_OF_SKIN": "Atypical scarring of skin", "HP_AUTISTIC_BEHAVIOR": "", "HP_AUDITORY_HYPERSENSITIVITY": "Auditory hypersensitivity", "HP_AUTOAMPUTATION": "Autoamputation", "HP_AUTOAMPUTATION_OF_DIGITS": "Autoamputation of digits", "HP_AUTISM": "Autism", "HP_AUTOIMMUNE_HEMOLYTIC_ANEMIA": "Autoimmune hemolytic anemia", "HP_AUTOIMMUNE_ANTIBODY_POSITIVITY": "Autoimmune antibody positivity", "HP_AUTOPHAGIC_VACUOLES": "Autophagic vacuoles", "HP_AUTOIMMUNE_THROMBOCYTOPENIA": "Autoimmune thrombocytopenia", "HP_AVASCULAR_NECROSIS_OF_THE_CAPITAL_FEMORAL_EPIPHYSIS": "Avascular necrosis of the capital femoral epiphysis", "HP_AVASCULAR_NECROSIS": "Avascular necrosis", "HP_AV_NODAL_TACHYCARDIA": "AV nodal tachycardia", "HP_AXIAL_DYSTONIA": "Axial dystonia", "HP_AUTOIMMUNITY": "Autoimmunity", "HP_AXILLARY_PTERYGIUM": "Axillary pterygium", "HP_AXILLARY_FRECKLING": "Axillary freckling", "HP_AXIAL_MUSCLE_WEAKNESS": "Axial muscle weakness", "HP_AXONAL_DEGENERATION": "Axonal degeneration", "HP_AXIAL_HYPOTONIA": "Axial hypotonia", "HP_AXONAL_DEGENERATION_REGENERATION": "Axonal degeneration/regeneration", "HP_AXONAL_LOSS": "Axonal loss", "HP_AXONAL_REGENERATION": "Axonal regeneration", "HP_AZOOSPERMIA": "Azoospermia", "HP_BAND_KERATOPATHY": "Band keratopathy", "HP_BABINSKI_SIGN": "", "HP_BARRETT_ESOPHAGUS": "Barrett esophagus", "HP_BARREL_SHAPED_CHEST": "Barrel-shaped chest", "HP_BACK_PAIN": "Back pain", "HP_BASAL_GANGLIA_CYSTS": "Basal ganglia cysts", "HP_BASAL_GANGLIA_GLIOSIS": "Basal ganglia gliosis", "HP_BASAL_GANGLIA_CALCIFICATION": "Basal ganglia calcification", "HP_BASAL_CELL_CARCINOMA": "Basal cell carcinoma", "HP_BCGITIS": "BCGitis", "HP_BASILAR_IMPRESSION": "Basilar impression", "HP_BCGOSIS": "BCGosis", "HP_BEAKING_OF_VERTEBRAL_BODIES": "Beaking of vertebral bodies", "HP_BELL_SHAPED_THORAX": "Bell-shaped thorax", "HP_BICARBONATURIA": "", "HP_BICARBONATE_WASTING_RENAL_TUBULAR_ACIDOSIS": "Bicarbonate-wasting renal tubular acidosis", "HP_BENIGN_NEOPLASM_OF_THE_CENTRAL_NERVOUS_SYSTEM": "Benign neoplasm of the central nervous system", "HP_BICONCAVE_VERTEBRAL_BODIES": "Biconcave vertebral bodies", "HP_BIFID_NOSE": "Bifid nose", "HP_BICORONAL_SYNOSTOSIS": "Bicoronal synostosis", "HP_BIFID_NASAL_TIP": "Bifid nasal tip", "HP_BICONVEX_VERTEBRAL_BODIES": "Biconvex vertebral bodies", "HP_BIFID_EPIGLOTTIS": "Bifid epiglottis", "HP_BIFID_RIBS": "Bifid ribs", "HP_BICORNUATE_UTERUS": "Bicornuate uterus", "HP_BIFID_TONGUE": "Bifid tongue", "HP_BIFID_URETER": "Bifid ureter", "HP_BIFID_SCROTUM": "Bifid scrotum", "HP_BILATERAL_CONDUCTIVE_HEARING_IMPAIRMENT": "Bilateral conductive hearing impairment", "HP_BILATERAL_CAMPTODACTYLY": "Bilateral camptodactyly", "HP_BILATERAL_CLEFT_LIP": "Bilateral cleft lip", "HP_BIFID_UVULA": "Bifid uvula", "HP_BILATERAL_CHOANAL_ATRESIA": "Bilateral choanal atresia", "HP_BILATERAL_RENAL_AGENESIS": "Bilateral renal agenesis", "HP_BILATERAL_COXA_VALGA": "Bilateral coxa valga", "HP_BILATERAL_MICROPHTHALMOS": "Bilateral microphthalmos", "HP_BILATERAL_PTOSIS": "Bilateral ptosis", "HP_BILATERAL_CRYPTORCHIDISM": "Bilateral cryptorchidism", "HP_BILATERAL_SUPERIOR_VENA_CAVA": "Bilateral superior vena cava", "HP_BILATERAL_SINGLE_TRANSVERSE_PALMAR_CREASES": "Bilateral single transverse palmar creases", "HP_BILATERAL_SENSORINEURAL_HEARING_IMPAIRMENT": "Bilateral sensorineural hearing impairment", "HP_BILATERAL_TALIPES_EQUINOVARUS": "Bilateral talipes equinovarus", "HP_BILE_DUCT_PROLIFERATION": "Bile duct proliferation", "HP_BILATERAL_TONIC_CLONIC_SEIZURE_WITH_GENERALIZED_ONSET": "Bilateral tonic-clonic seizure with generalized onset", "HP_BILIARY_ATRESIA": "Biliary atresia", "HP_BILATERAL_TONIC_CLONIC_SEIZURE_WITH_FOCAL_ONSET": "Bilateral tonic-clonic seizure with focal onset", "HP_BILATERAL_TONIC_CLONIC_SEIZURE": "Bilateral tonic-clonic seizure", "HP_BILIARY_CIRRHOSIS": "Biliary cirrhosis", "HP_BILIARY_TRACT_ABNORMALITY": "Biliary tract abnormality", "HP_BILIARY_TRACT_NEOPLASM": "Biliary tract neoplasm", "HP_BIPARIETAL_NARROWING": "Biparietal narrowing", "HP_BIPOLAR_AFFECTIVE_DISORDER": "Bipolar affective disorder", "HP_BIRD_LIKE_FACIES": "Bird-like facies", "HP_BIRTH_LENGTH_LESS_THAN_3RD_PERCENTILE": "Birth length less than 3rd percentile", "HP_BIRTH_LENGTH_GREATER_THAN_97TH_PERCENTILE": "Birth length greater than 97th percentile", "HP_BITEMPORAL_HEMIANOPIA": "Bitemporal hemianopia", "HP_BIVENTRICULAR_HYPERTROPHY": "Biventricular hypertrophy", "HP_BLADDER_NEOPLASM": "Bladder neoplasm", "HP_BLADDER_DIVERTICULUM": "Bladder diverticulum", "HP_BLEEDING_WITH_MINOR_OR_NO_TRAUMA": "Bleeding with minor or no trauma", "HP_BLEPHAROCHALASIS": "Blepharochalasis", "HP_BLEPHARITIS": "Blepharitis", "HP_BLEPHAROPHIMOSIS": "Blepharophimosis", "HP_BLIND_VAGINA": "Blind vagina", "HP_BLISTERING_BY_ANATOMICAL_LOCATION": "Blistering by anatomical location", "HP_BLISTERING_BY_HISTOLOGICAL_LOCATION": "Blistering by histological location", "HP_BLOCK_VERTEBRAE": "Block vertebrae", "HP_BLUE_NEVUS": "Blue nevus", "HP_BLOODY_DIARRHEA": "Bloody diarrhea", "HP_BLINDNESS": "Blindness", "HP_BLUE_IRIDES": "Blue irides", "HP_BLUE_SCLERAE": "Blue sclerae", "HP_BONE_CYST": "Bone cyst", "HP_BONE_FRACTURE": "Bone fracture", "HP_BONE_MARROW_FOAM_CELLS": "Bone-marrow foam cells", "HP_BLURRED_VISION": "Blurred vision", "HP_BONE_MARROW_HYPERCELLULARITY": "Bone marrow hypercellularity", "HP_BONE_MARROW_MATURATION_ARREST": "Bone marrow maturation arrest", "HP_BONE_SPICULE_PIGMENTATION_OF_THE_RETINA": "", "HP_BONE_MARROW_HYPOCELLULARITY": "Bone marrow hypocellularity", "HP_BONE_PAIN": "Bone pain", "HP_BOWED_HUMERUS": "Bowed humerus", "HP_BOWED_FOREARM_BONES": "Bowed forearm bones", "HP_BOWEL_DIVERTICULOSIS": "Bowel diverticulosis", "HP_BOWING_OF_THE_ARM": "Bowing of the arm", "HP_BRACHYTURRICEPHALY": "Brachyturricephaly", "HP_BRACHYCEPHALY": "Brachycephaly", "HP_BOWING_OF_THE_LEGS": "Bowing of the legs", "HP_BRADYCARDIA": "Bradycardia", "HP_BRADYPHRENIA": "", "HP_BRADYKINESIA": "Bradykinesia", "HP_BRACHYDACTYLY": "Brachydactyly", "HP_BRAIN_NEOPLASM": "Brain neoplasm", "HP_BRAIN_STEM_COMPRESSION": "Brain stem compression", "HP_BRAIN_IMAGING_ABNORMALITY": "Brain imaging abnormality", "HP_BRANCHIAL_ANOMALY": "Branchial anomaly", "HP_BRANCHIAL_CYST": "Branchial cyst", "HP_BRANCHIAL_FISTULA": "Branchial fistula", "HP_BREAST_APLASIA": "Breast aplasia", "HP_BREATHING_DYSREGULATION": "Breathing dysregulation", "HP_BREAST_CARCINOMA": "Breast carcinoma", "HP_BREAST_HYPOPLASIA": "Breast hypoplasia", "HP_BROAD_ALVEOLAR_RIDGES": "Broad alveolar ridges", "HP_BREECH_PRESENTATION": "Breech presentation", "HP_BRISK_REFLEXES": "Brisk reflexes", "HP_BRITTLE_HAIR": "Brittle hair", "HP_BROAD_BASED_GAIT": "Broad-based gait", "HP_BROAD_CHIN": "Broad chin", "HP_BROAD_CLAVICLES": "Broad clavicles", "HP_BROAD_COLUMELLA": "Broad columella", "HP_BROAD_DISTAL_PHALANX_OF_FINGER": "Broad distal phalanx of finger", "HP_BROAD_DISTAL_PHALANX_OF_THE_TOES": "Broad distal phalanx of the toes", "HP_BROAD_EYEBROW": "Broad eyebrow", "HP_BROAD_FACE": "Broad face", "HP_BROAD_FEMORAL_NECK": "Broad femoral neck", "HP_BROAD_FOOT": "Broad foot", "HP_BROAD_FIRST_METATARSAL": "Broad first metatarsal", "HP_BROAD_FINGER": "Broad finger", "HP_BROAD_HALLUX_PHALANX": "Broad hallux phalanx", "HP_BROAD_JAW": "Broad jaw", "HP_BROAD_ISCHIA": "Broad ischia", "HP_BROAD_FOREHEAD": "Broad forehead", "HP_BROAD_METACARPALS": "Broad metacarpals", "HP_BROAD_METATARSAL": "Broad metatarsal", "HP_BROAD_LONG_BONES": "Broad long bones", "HP_BROAD_NAIL": "Broad nail", "HP_BROAD_NECK": "Broad neck", "HP_BROAD_PALM": "Broad palm", "HP_BROAD_NASAL_TIP": "Broad nasal tip", "HP_BROAD_PHALANX_OF_THE_TOES": "Broad phalanx of the toes", "HP_BROAD_PHALANGES_OF_THE_HAND": "Broad phalanges of the hand", "HP_BROAD_PHILTRUM": "Broad philtrum", "HP_BROAD_RIBS": "Broad ribs", "HP_BROAD_THUMB": "Broad thumb", "HP_BRONCHIAL_WALL_THICKENING": "Bronchial wall thickening", "HP_BROAD_TOE": "Broad toe", "HP_BRONCHOMALACIA": "Bronchomalacia", "HP_BRONCHIECTASIS": "Bronchiectasis", "HP_BRUSHFIELD_SPOTS": "Brushfield spots", "HP_BRONCHITIS": "Bronchitis", "HP_BUDD_CHIARI_SYNDROME": "Budd-Chiari syndrome", "HP_BRUXISM": "Bruxism", "HP_BRUISING_SUSCEPTIBILITY": "Bruising susceptibility", "HP_BULBAR_SIGNS": "Bulbar signs", "HP_BULBAR_PALSY": "Bulbar palsy", "HP_BULIMIA": "Bulimia", "HP_BULBOUS_NOSE": "Bulbous nose", "HP_BULL_S_EYE_MACULOPATHY": "Bull's eye maculopathy", "HP_BUPHTHALMOS": "Buphthalmos", "HP_BURKITT_LYMPHOMA": "Burkitt lymphoma", "HP_BUNDLE_BRANCH_BLOCK": "Bundle branch block", "HP_BUTTERFLY_VERTEBRAE": "Butterfly vertebrae", "HP_B_CELL_LYMPHOMA": "B-cell lymphoma", "HP_C1_C2_SUBLUXATION": "C1-C2 subluxation", "HP_B_LYMPHOCYTOPENIA": "", "HP_C1_C2_VERTEBRAL_ABNORMALITY": "C1-C2 vertebral abnormality", "HP_CACHEXIA": "Cachexia", "HP_CAFE_AU_LAIT_SPOT": "Cafe-au-lait spot", "HP_CALCIFICATION_OF_FALX_CEREBRI": "Calcification of falx cerebri", "HP_CALCIFICATION_OF_CARTILAGE": "Calcification of cartilage", "HP_CALCIFIC_STIPPLING": "Calcific stippling", "HP_CALCIFICATION_OF_THE_AORTA": "Calcification of the aorta", "HP_CALCINOSIS": "Calcinosis", "HP_CAESARIAN_SECTION": "", "HP_CALF_MUSCLE_HYPERTROPHY": "Calf muscle hypertrophy", "HP_CALCIUM_NEPHROLITHIASIS": "Calcium nephrolithiasis", "HP_CALF_MUSCLE_PSEUDOHYPERTROPHY": "Calf muscle pseudohypertrophy", "HP_CALVARIAL_HYPEROSTOSIS": "Calvarial hyperostosis", "HP_CALVARIAL_OSTEOSCLEROSIS": "Calvarial osteosclerosis", "HP_CALVARIAL_SKULL_DEFECT": "Calvarial skull defect", "HP_CAMPTODACTYLY_OF_TOE": "Camptodactyly of toe", "HP_CANDIDA_ESOPHAGITIS": "Candida esophagitis", "HP_CAPILLARY_FRAGILITY": "Capillary fragility", "HP_CAPILLARY_HEMANGIOMA": "Capillary hemangioma", "HP_CAPILLARY_MALFORMATION": "Capillary malformation", "HP_CARCINOMA": "Carcinoma", "HP_CARCINOID_TUMOR": "Carcinoid tumor", "HP_CARDIAC_DIVERTICULUM": "Cardiac diverticulum", "HP_CARDIAC_SHUNT": "Cardiac shunt", "HP_CARDIAC_ARREST": "Cardiac arrest", "HP_CARDIAC_VALVE_CALCIFICATION": "Cardiac valve calcification", "HP_CARDIOGENIC_SHOCK": "Cardiogenic shock", "HP_CARDIAC_CONDUCTION_ABNORMALITY": "Cardiac conduction abnormality", "HP_CARDIOMYOCYTE_HYPERTROPHY": "Cardiomyocyte hypertrophy", "HP_CARDIORESPIRATORY_ARREST": "Cardiorespiratory arrest", "HP_CARDIOMEGALY": "Cardiomegaly", "HP_CARDIOVASCULAR_CALCIFICATION": "Cardiovascular calcification", "HP_CAROTID_ARTERY_DILATATION": "Carotid artery dilatation", "HP_CAROTID_ARTERY_STENOSIS": "Carotid artery stenosis", "HP_CAROTID_ARTERY_TORTUOSITY": "Carotid artery tortuosity", "HP_CARPAL_BONE_HYPOPLASIA": "Carpal bone hypoplasia", "HP_CARIOUS_TEETH": "Carious teeth", "HP_CARPAL_SYNOSTOSIS": "Carpal synostosis", "HP_CAUDAL_APPENDAGE": "Caudal appendage", "HP_CATAPLEXY": "Cataplexy", "HP_CAVERNOUS_HEMANGIOMA": "Cavernous hemangioma", "HP_CAUDATE_ATROPHY": "Caudate atrophy", "HP_CELIAC_DISEASE": "Celiac disease", "HP_CAVUM_SEPTUM_PELLUCIDUM": "Cavum septum pellucidum", "HP_CELLULAR_IMMUNODEFICIENCY": "Cellular immunodeficiency", "HP_CELLULITIS": "Cellulitis", "HP_CENTRAL_ADRENAL_INSUFFICIENCY": "Central adrenal insufficiency", "HP_CENTRAL_DIABETES_INSIPIDUS": "Central diabetes insipidus", "HP_CENTRALLY_NUCLEATED_SKELETAL_MUSCLE_FIBERS": "Centrally nucleated skeletal muscle fibers", "HP_CENTRAL_APNEA": "Central apnea", "HP_CENTRAL_HETEROCHROMIA": "Central heterochromia", "HP_CENTRAL_HYPOTHYROIDISM": "Central hypothyroidism", "HP_CENTRAL_HYPOVENTILATION": "Central hypoventilation", "HP_CENTRAL_PRIMITIVE_NEUROECTODERMAL_TUMOR": "Central primitive neuroectodermal tumor", "HP_CENTRAL_OPACIFICATION_OF_THE_CORNEA": "Central opacification of the cornea", "HP_CENTRAL_NERVOUS_SYSTEM_CYST": "Central nervous system cyst", "HP_CENTRAL_SLEEP_APNEA": "Central sleep apnea", "HP_CENTRAL_Y_SHAPED_METACARPAL": "Central Y-shaped metacarpal", "HP_CENTRAL_SCOTOMA": "Central scotoma", "HP_CENTROCECAL_SCOTOMA": "Centrocecal scotoma", "HP_CEPHALOHEMATOMA": "Cephalohematoma", "HP_CEREBELLAR_CALCIFICATIONS": "Cerebellar calcifications", "HP_CEREBELLAR_CORTICAL_ATROPHY": "Cerebellar cortical atrophy", "HP_CEREBELLAR_DENTATE_NUCLEUS_CALCIFICATION": "Cerebellar dentate nucleus calcification", "HP_CEREBELLAR_DYSPLASIA": "Cerebellar dysplasia", "HP_CEREBELLAR_HEMISPHERE_HYPOPLASIA": "Cerebellar hemisphere hypoplasia", "HP_CEREBELLAR_ATROPHY": "Cerebellar atrophy", "HP_CEREBELLAR_CYST": "Cerebellar cyst", "HP_CEREBELLAR_HEMORRHAGE": "Cerebellar hemorrhage", "HP_CEREBELLAR_MALFORMATION": "", "HP_CEREBRAL_AMYLOID_ANGIOPATHY": "Cerebral amyloid angiopathy", "HP_CEREBELLAR_VERMIS_ATROPHY": "Cerebellar vermis atrophy", "HP_CEREBRAL_ARTERIOVENOUS_MALFORMATION": "Cerebral arteriovenous malformation", "HP_CEREBRAL_BERRY_ANEURYSM": "Cerebral berry aneurysm", "HP_CEREBRAL_CAVERNOUS_MALFORMATION": "Cerebral cavernous malformation", "HP_CEREBRAL_CORTICAL_HEMIATROPHY": "Cerebral cortical hemiatrophy", "HP_CEREBRAL_DYSMYELINATION": "Cerebral dysmyelination", "HP_CEREBRAL_EDEMA": "Cerebral edema", "HP_CEREBRAL_HAMARTOMA": "Cerebral hamartoma", "HP_CEREBRAL_HYPOMYELINATION": "Cerebral hypomyelination", "HP_CEREBRAL_HEMORRHAGE": "Cerebral hemorrhage", "HP_CEREBRAL_CORTICAL_ATROPHY": "Cerebral cortical atrophy", "HP_CEREBRAL_INCLUSION_BODIES": "Cerebral inclusion bodies", "HP_CEREBRAL_HYPOPLASIA": "Cerebral hypoplasia", "HP_CEREBRAL_INFARCT": "Cerebral infarct", "HP_CEREBRAL_PALSY": "Cerebral palsy", "HP_CEREBRAL_WHITE_MATTER_ATROPHY": "Cerebral white matter atrophy", "HP_CERVICAL_C2_C3_VERTEBRAL_FUSION": "Cervical C2/C3 vertebral fusion", "HP_CEREBRAL_WHITE_MATTER_HYPOPLASIA": "Cerebral white matter hypoplasia", "HP_CERVICAL_CORD_COMPRESSION": "Cervical cord compression", "HP_CEREBRAL_VENOUS_THROMBOSIS": "Cerebral venous thrombosis", "HP_CERVICAL_LYMPHADENOPATHY": "Cervical lymphadenopathy", "HP_CERVICAL_KYPHOSIS": "Cervical kyphosis", "HP_CEREBRAL_VISUAL_IMPAIRMENT": "Cerebral visual impairment", "HP_CERVICAL_MYELOPATHY": "Cervical myelopathy", "HP_CERVICAL_NEOPLASM": "Cervical neoplasm", "HP_CERVICAL_RIBS": "Cervical ribs", "HP_CERVICAL_SPINAL_CANAL_STENOSIS": "Cervical spinal canal stenosis", "HP_CERVICAL_SPINAL_CORD_ATROPHY": "Cervical spinal cord atrophy", "HP_CERVICAL_SPINE_INSTABILITY": "Cervical spine instability", "HP_CERVICAL_SUBLUXATION": "Cervical subluxation", "HP_CHEILITIS": "Cheilitis", "HP_CESSATION_OF_HEAD_GROWTH": "Cessation of head growth", "HP_CHERRY_RED_SPOT_OF_THE_MACULA": "Cherry red spot of the macula", "HP_CHIARI_MALFORMATION": "Chiari malformation", "HP_CHEST_PAIN": "Chest pain", "HP_CHILBLAINS": "Chilblains", "HP_CHIARI_TYPE_I_MALFORMATION": "Chiari type I malformation", "HP_CHILDHOOD_ONSET_TRUNCAL_OBESITY": "Childhood-onset truncal obesity", "HP_CHILLS": "Chills", "HP_CHILDHOOD_ONSET_SENSORINEURAL_HEARING_IMPAIRMENT": "Childhood onset sensorineural hearing impairment", "HP_CHIN_WITH_H_SHAPED_CREASE": "Chin with H-shaped crease", "HP_CHIN_WITH_HORIZONTAL_CREASE": "Chin with horizontal crease", "HP_CHOANAL_STENOSIS": "Choanal stenosis", "HP_CHOKING_EPISODES": "Choking episodes", "HP_CHOANAL_ATRESIA": "Choanal atresia", "HP_CHOLANGIOCARCINOMA": "Cholangiocarcinoma", "HP_CHOLANGITIS": "Cholangitis", "HP_CHILDHOOD_ONSET": "Childhood onset", "HP_CHOLESTATIC_LIVER_DISEASE": "Cholestatic liver disease", "HP_CHOLESTEATOMA": "", "HP_CHONDROCALCINOSIS": "Chondrocalcinosis", "HP_CHONDROSARCOMA": "Chondrosarcoma", "HP_CHOLESTASIS": "Cholestasis", "HP_CHORDEE": "", "HP_CHORIOCAPILLARIS_ATROPHY": "Choriocapillaris atrophy", "HP_CHORIOCARCINOMA": "", "HP_CHOREA": "Chorea", "HP_CHOREOATHETOSIS": "Choreoathetosis", "HP_CHORIORETINAL_DEGENERATION": "", "HP_CHORIORETINAL_ATROPHY": "Chorioretinal atrophy", "HP_CHORIORETINAL_HYPOPIGMENTATION": "Chorioretinal hypopigmentation", "HP_CHORIORETINAL_COLOBOMA": "Chorioretinal coloboma", "HP_CHORIORETINAL_DYSPLASIA": "Chorioretinal dysplasia", "HP_CHOROIDAL_HEMANGIOMA": "Choroidal hemangioma", "HP_CHOROIDAL_NEOVASCULARIZATION": "Choroidal neovascularization", "HP_CHOROID_PLEXUS_CARCINOMA": "Choroid plexus carcinoma", "HP_CHOROIDEREMIA": "", "HP_CHOROID_PLEXUS_CYST": "Choroid plexus cyst", "HP_CHROMOSOMAL_BREAKAGE_INDUCED_BY_CROSSLINKING_AGENTS": "Chromosomal breakage induced by crosslinking agents", "HP_CHRONIC_AXONAL_NEUROPATHY": "Chronic axonal neuropathy", "HP_CHROMOSOMAL_BREAKAGE_INDUCED_BY_IONIZING_RADIATION": "Chromosomal breakage induced by ionizing radiation", "HP_CHRONIC_BRONCHITIS": "Chronic bronchitis", "HP_CHROMOSOME_BREAKAGE": "Chromosome breakage", "HP_CHRONIC_CSF_LYMPHOCYTOSIS": "Chronic CSF lymphocytosis", "HP_CHRONIC_FATIGUE": "Chronic fatigue", "HP_CHRONIC_CONSTIPATION": "Chronic constipation", "HP_CHRONIC_GASTRITIS": "Chronic gastritis", "HP_CHRONIC_FURUNCULOSIS": "Chronic furunculosis", "HP_CHRONIC_DIARRHEA": "Chronic diarrhea", "HP_CHRONIC_HEPATITIS_DUE_TO_CRYPTOSPORIDIUM_INFECTION": "Chronic hepatitis due to cryptosporidium infection", "HP_CHRONIC_HEPATIC_FAILURE": "Chronic hepatic failure", "HP_CHRONIC_HEPATITIS": "Chronic hepatitis", "HP_CHRONIC_HEMOLYTIC_ANEMIA": "Chronic hemolytic anemia", "HP_CHRONIC_INFECTION": "Chronic infection", "HP_CHRONIC_LEUKEMIA": "Chronic leukemia", "HP_CHRONIC_LYMPHOCYTIC_MENINGITIS": "", "HP_CHRONIC_LYMPHATIC_LEUKEMIA": "Chronic lymphatic leukemia", "HP_CHRONIC_KIDNEY_DISEASE": "Chronic kidney disease", "HP_CHRONIC_LUNG_DISEASE": "Chronic lung disease", "HP_CHRONIC_MYELOGENOUS_LEUKEMIA": "Chronic myelogenous leukemia", "HP_CHRONIC_NEUTROPENIA": "", "HP_CHRONIC_NONINFECTIOUS_LYMPHADENOPATHY": "Chronic noninfectious lymphadenopathy", "HP_CHRONIC_ORAL_CANDIDIASIS": "Chronic oral candidiasis", "HP_CHRONIC_PAIN": "Chronic pain", "HP_CHRONIC_PANCREATITIS": "Chronic pancreatitis", "HP_CHRONIC_OTITIS_MEDIA": "Chronic otitis media", "HP_CHRONIC_PULMONARY_OBSTRUCTION": "Chronic pulmonary obstruction", "HP_CHRONIC_RHINITIS": "Chronic rhinitis", "HP_CHRONIC_SINUSITIS": "Chronic sinusitis", "HP_CIGARETTE_PAPER_SCARS": "Cigarette-paper scars", "HP_CHYLOTHORAX": "Chylothorax", "HP_CLASS_III_OBESITY": "Class III obesity", "HP_CLAW_HAND_DEFORMITY": "Claw hand deformity", "HP_CLEFT_ALA_NASI": "Cleft ala nasi", "HP_CIRRHOSIS": "Cirrhosis", "HP_CLINODACTYLY_OF_THE_2ND_FINGER": "Clinodactyly of the 2nd finger", "HP_CLEFT_SOFT_PALATE": "Cleft soft palate", "HP_CLEFT_LIP": "Cleft lip", "HP_CLINODACTYLY_OF_THE_3RD_FINGER": "Clinodactyly of the 3rd finger", "HP_CLINODACTYLY_OF_THE_5TH_TOE": "Clinodactyly of the 5th toe", "HP_CLEFT_UPPER_LIP": "Cleft upper lip", "HP_CLITORAL_HYPOPLASIA": "", "HP_CLEFT_PALATE": "Cleft palate", "HP_CLITORAL_HYPERTROPHY": "Clitoral hypertrophy", "HP_CLONUS": "Clonus", "HP_CLINODACTYLY": "Clinodactyly", "HP_CLONIC_SEIZURE": "Clonic seizure", "HP_CLOVERLEAF_SKULL": "Cloverleaf skull", "HP_CLOSED_NEURAL_TUBE_DEFECT": "Closed neural tube defect", "HP_CLUBBING_OF_TOES": "Clubbing of toes", "HP_CLUBBING_OF_FINGERS": "Clubbing of fingers", "HP_CLUMSINESS": "Clumsiness", "HP_CNS_DEMYELINATION": "CNS demyelination", "HP_CLUBBING": "Clubbing", "HP_CNS_HYPOMYELINATION": "CNS hypomyelination", "HP_COCHLEAR_MALFORMATION": "Cochlear malformation", "HP_COGNITIVE_DISTORTION": "Cognitive distortion", "HP_COARSE_HAIR": "Coarse hair", "HP_COARSE_FACIAL_FEATURES": "Coarse facial features", "HP_COGWHEEL_RIGIDITY": "Cogwheel rigidity", "HP_COARCTATION_OF_AORTA": "Coarctation of aorta", "HP_COLDNESS": "Coldness", "HP_COILED_SPERM_FLAGELLA": "Coiled sperm flagella", "HP_COLD_INDUCED_MUSCLE_CRAMPS": "Cold-induced muscle cramps", "HP_COLLECTIONISM": "Collectionism", "HP_COLITIS": "Colitis", "HP_COLORECTAL_POLYPOSIS": "Colorectal polyposis", "HP_COLON_CANCER": "Colon cancer", "HP_COGNITIVE_IMPAIRMENT": "Cognitive impairment", "HP_COLOR_VISION_TEST_ABNORMALITY": "Color vision test abnormality", "HP_COLOBOMA": "Coloboma", "HP_COLPOCEPHALY": "Colpocephaly", "HP_COLOR_VISION_DEFECT": "Color vision defect", "HP_COMA": "Coma", "HP_COMBINED_IMMUNODEFICIENCY": "Combined immunodeficiency", "HP_COMMUNICATING_HYDROCEPHALUS": "Communicating hydrocephalus", "HP_COMMON_ATRIUM": "Common atrium", "HP_COMPENSATORY_HEAD_POSTURE": "Compensatory head posture", "HP_COMPLETE_ATRIOVENTRICULAR_CANAL_DEFECT": "Complete atrioventricular canal defect", "HP_COMPENSATED_HYPOTHYROIDISM": "Compensated hypothyroidism", "HP_COMPLETE_DUPLICATION_OF_PHALANX_OF_HAND": "Complete duplication of phalanx of hand", "HP_COMPLETE_OR_NEAR_COMPLETE_ABSENCE_OF_SPECIFIC_ANTIBODY_RESPONSE_TO_TETANUS_VACCINE": "Complete or near-complete absence of specific antibody response to tetanus vaccine", "HP_COMPLETE_OR_NEAR_COMPLETE_ABSENCE_OF_SPECIFIC_ANTIBODY_RESPONSE_TO_UNCONJUGATED_PNEUMOCOCCUS_VACCINE": "Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine", "HP_COMPLEX_FEBRILE_SEIZURE": "Complex febrile seizure", "HP_CONCAVE_NASAL_RIDGE": "Concave nasal ridge", "HP_CONCAVE_NAIL": "Concave nail", "HP_COMPULSIVE_BEHAVIORS": "Compulsive behaviors", "HP_CONCENTRIC_HYPERTROPHIC_CARDIOMYOPATHY": "Concentric hypertrophic cardiomyopathy", "HP_CONE_SHAPED_EPIPHYSES_OF_THE_PHALANGES_OF_THE_HAND": "", "HP_CONE_CONE_ROD_DYSTROPHY": "Cone/cone-rod dystrophy", "HP_CONFETTI_LIKE_HYPOPIGMENTED_MACULES": "Confetti-like hypopigmented macules", "HP_CONE_SHAPED_METACARPAL_EPIPHYSES": "Cone-shaped metacarpal epiphyses", "HP_CONE_SHAPED_EPIPHYSIS": "Cone-shaped epiphysis", "HP_CONFUSIONAL_AROUSAL": "", "HP_CONGENITAL_ADRENAL_HYPERPLASIA": "Congenital adrenal hyperplasia", "HP_CONFUSION": "Confusion", "HP_CONGENITAL_BILATERAL_HIP_DISLOCATION": "Congenital bilateral hip dislocation", "HP_CONGENITAL_BLINDNESS": "Congenital blindness", "HP_CONGENITAL_ABNORMAL_HAIR_PATTERN": "Congenital abnormal hair pattern", "HP_CONGENITAL_DIAPHRAGMATIC_HERNIA": "Congenital diaphragmatic hernia", "HP_CONGENITAL_FINGER_FLEXION_CONTRACTURES": "Congenital finger flexion contractures", "HP_CONGENITAL_FIBROSIS_OF_EXTRAOCULAR_MUSCLES": "Congenital fibrosis of extraocular muscles", "HP_CONGENITAL_GIANT_MELANOCYTIC_NEVUS": "Congenital giant melanocytic nevus", "HP_CONGENITAL_CONTRACTURE": "Congenital contracture", "HP_CONGENITAL_HEMOLYTIC_ANEMIA": "Congenital hemolytic anemia", "HP_CONGENITAL_HYPOPLASTIC_ANEMIA": "Congenital hypoplastic anemia", "HP_CONGENITAL_HIP_DISLOCATION": "Congenital hip dislocation", "HP_CONGENITAL_HEPATIC_FIBROSIS": "Congenital hepatic fibrosis", "HP_CONGENITAL_HYPOTHYROIDISM": "Congenital hypothyroidism", "HP_CONGENITAL_LOCALIZED_ABSENCE_OF_SKIN": "Congenital localized absence of skin", "HP_CONGENITAL_LARYNGEAL_STRIDOR": "Congenital laryngeal stridor", "HP_CONGENITAL_ICHTHYOSIFORM_ERYTHRODERMA": "Congenital ichthyosiform erythroderma", "HP_CONGENITAL_MUSCULAR_TORTICOLLIS": "Congenital muscular torticollis", "HP_CONGENITAL_MALFORMATION_OF_THE_RIGHT_HEART": "Congenital malformation of the right heart", "HP_CONGENITAL_NYSTAGMUS": "Congenital nystagmus", "HP_CONGENITAL_NONBULLOUS_ICHTHYOSIFORM_ERYTHRODERMA": "Congenital nonbullous ichthyosiform erythroderma", "HP_CONGENITAL_POSTERIOR_URETHRAL_VALVE": "Congenital posterior urethral valve", "HP_CONGENITAL_MALFORMATION_OF_THE_GREAT_ARTERIES": "Congenital malformation of the great arteries", "HP_CONGENITAL_THROMBOCYTOPENIA": "Congenital thrombocytopenia", "HP_CONGENITAL_PTOSIS": "Congenital ptosis", "HP_CONGENITAL_STATIONARY_NIGHT_BLINDNESS": "", "HP_CONGENITAL_SENSORINEURAL_HEARING_IMPAIRMENT": "Congenital sensorineural hearing impairment", "HP_CONGENITAL_ONSET": "Congenital onset", "HP_CONICAL_INCISOR": "Conical incisor", "HP_CONICAL_TOOTH": "Conical tooth", "HP_CONJUGATED_HYPERBILIRUBINEMIA": "Conjugated hyperbilirubinemia", "HP_CONJUNCTIVAL_HAMARTOMA": "Conjunctival hamartoma", "HP_CONGESTIVE_HEART_FAILURE": "Congestive heart failure", "HP_CONJUNCTIVAL_HYPEREMIA": "Conjunctival hyperemia", "HP_CONNECTIVE_TISSUE_NEVI": "Connective tissue nevi", "HP_CONJUNCTIVAL_ICTERUS": "Conjunctival icterus", "HP_CONSPICUOUSLY_HAPPY_DISPOSITION": "Conspicuously happy disposition", "HP_CONTINUOUS_SPIKE_AND_WAVES_DURING_SLOW_SLEEP": "Continuous spike and waves during slow sleep", "HP_CONSTIPATION": "Constipation", "HP_CONSTRICTION_OF_PERIPHERAL_VISUAL_FIELD": "Constriction of peripheral visual field", "HP_CONTRACTURE_OF_THE_DISTAL_INTERPHALANGEAL_JOINT_OF_THE_FINGERS": "Contracture of the distal interphalangeal joint of the fingers", "HP_CONTRACTURE_OF_THE_PROXIMAL_INTERPHALANGEAL_JOINT_OF_THE_4TH_FINGER": "Contracture of the proximal interphalangeal joint of the 4th finger", "HP_CONTRACTURE_OF_THE_PROXIMAL_INTERPHALANGEAL_JOINT_OF_THE_3RD_FINGER": "", "HP_CONTRACTURE_OF_THE_PROXIMAL_INTERPHALANGEAL_JOINT_OF_THE_5TH_FINGER": "Contracture of the proximal interphalangeal joint of the 5th finger", "HP_CONVULSIVE_STATUS_EPILEPTICUS": "Convulsive status epilepticus", "HP_CONVEX_NASAL_RIDGE": "Convex nasal ridge", "HP_COOMBS_POSITIVE_HEMOLYTIC_ANEMIA": "Coombs-positive hemolytic anemia", "HP_CONSTITUTIONAL_SYMPTOM": "Constitutional symptom", "HP_CORNEAL_DYSTROPHY": "Corneal dystrophy", "HP_CORNEAL_GUTTATA": "Corneal guttata", "HP_CORNEAL_SCARRING": "Corneal scarring", "HP_CORNEAL_EROSION": "Corneal erosion", "HP_CORNEAL_NEOVASCULARIZATION": "Corneal neovascularization", "HP_CORNEAL_STROMAL_EDEMA": "Corneal stromal edema", "HP_CORNEAL_ULCERATION": "Corneal ulceration", "HP_CORNEAL_OPACITY": "Corneal opacity", "HP_CORONAL_CLEFT_VERTEBRAE": "Coronal cleft vertebrae", "HP_CORONAL_CRANIOSYNOSTOSIS": "Coronal craniosynostosis", "HP_CORONARY_ARTERY_ANEURYSM": "Coronary artery aneurysm", "HP_CORPUS_CALLOSUM_ATROPHY": "Corpus callosum atrophy", "HP_CORONARY_ARTERY_STENOSIS": "Coronary artery stenosis", "HP_CORTICAL_CATARACT": "Cortical cataract", "HP_CORONARY_ARTERY_ATHEROSCLEROSIS": "Coronary artery atherosclerosis", "HP_CORTICAL_MYOCLONUS": "Cortical myoclonus", "HP_CORTICAL_DYSPLASIA": "Cortical dysplasia", "HP_CORTICAL_SCLEROSIS": "Cortical sclerosis", "HP_COR_PULMONALE": "Cor pulmonale", "HP_CORTICAL_THICKENING_OF_LONG_BONE_DIAPHYSES": "Cortical thickening of long bone diaphyses", "HP_CRACKLES": "Crackles", "HP_CRANIAL_ASYMMETRY": "Cranial asymmetry", "HP_COXA_VALGA": "Coxa valga", "HP_COUGH": "Cough", "HP_COXA_VARA": "Coxa vara", "HP_CRANIAL_HYPEROSTOSIS": "Cranial hyperostosis", "HP_CRANIAL_NERVE_PARALYSIS": "", "HP_CRANIAL_NERVE_COMPRESSION": "Cranial nerve compression", "HP_CRANIOFACIAL_DISPROPORTION": "Craniofacial disproportion", "HP_CRANIOFACIAL_ASYMMETRY": "Craniofacial asymmetry", "HP_CRANIOFACIAL_HYPEROSTOSIS": "Craniofacial hyperostosis", "HP_CRANIOFACIAL_DYSOSTOSIS": "Craniofacial dysostosis", "HP_CRANIOFACIAL_OSTEOSCLEROSIS": "Craniofacial osteosclerosis", "HP_CROHN_S_DISEASE": "Crohn's disease", "HP_CROSSED_FUSED_RENAL_ECTOPIA": "Crossed fused renal ectopia", "HP_CRUMPLED_EAR": "Crumpled ear", "HP_CRUMPLED_LONG_BONES": "Crumpled long bones", "HP_CRYPTOPHTHALMOS": "Cryptophthalmos", "HP_CRANIOSYNOSTOSIS": "Craniosynostosis", "HP_CSF_PLEOCYTOSIS": "CSF pleocytosis", "HP_CRYPTOZOOSPERMIA": "Cryptozoospermia", "HP_CSF_LYMPHOCYTIC_PLEIOCYTOSIS": "CSF lymphocytic pleiocytosis", "HP_CUBITUS_VALGUS": "Cubitus valgus", "HP_CUPPED_RIBS": "Cupped ribs", "HP_CURLY_EYELASHES": "Curly eyelashes", "HP_CRYPTORCHIDISM": "Cryptorchidism", "HP_CUPPED_EAR": "Cupped ear", "HP_CURVILINEAR_INTRACELLULAR_ACCUMULATION_OF_AUTOFLUORESCENT_LIPOPIGMENT_STORAGE_MATERIAL": "Curvilinear intracellular accumulation of autofluorescent lipopigment storage material", "HP_CURLY_HAIR": "Curly hair", "HP_CUTANEOUS_ABSCESS": "Cutaneous abscess", "HP_CUTANEOUS_AMYLOIDOSIS": "Cutaneous amyloidosis", "HP_CUTANEOUS_ANERGY": "", "HP_CUTANEOUS_CYST": "Cutaneous cyst", "HP_CUTANEOUS_MELANOMA": "Cutaneous melanoma", "HP_CUTANEOUS_PHOTOSENSITIVITY": "Cutaneous photosensitivity", "HP_CUTANEOUS_FINGER_SYNDACTYLY": "Cutaneous finger syndactyly", "HP_CUTANEOUS_SYNDACTYLY": "Cutaneous syndactyly", "HP_CUTANEOUS_SYNDACTYLY_OF_TOES": "Cutaneous syndactyly of toes", "HP_CUTIS_LAXA": "Cutis laxa", "HP_CYANOTIC_EPISODE": "Cyanotic episode", "HP_CUTIS_MARMORATA": "Cutis marmorata", "HP_CYCLOPIA": "Cyclopia", "HP_CYANOSIS": "Cyanosis", "HP_CYSTATHIONINEMIA": "Cystathioninemia", "HP_CYSTIC_LIVER_DISEASE": "Cystic liver disease", "HP_CYSTIC_HYGROMA": "Cystic hygroma", "HP_CYSTINURIA": "Cystinuria", "HP_CYSTIC_RENAL_DYSPLASIA": "Cystic renal dysplasia", "HP_CYSTOID_MACULAR_EDEMA": "Cystoid macular edema", "HP_CYTOCHROME_C_OXIDASE_NEGATIVE_MUSCLE_FIBERS": "Cytochrome C oxidase-negative muscle fibers", "HP_DACRYOCYSTITIS": "Dacryocystitis", "HP_DARK_URINE": "Dark urine", "HP_DEATH_IN_ADOLESCENCE": "Death in adolescence", "HP_DEATH_IN_ADULTHOOD": "Death in adulthood", "HP_DECEREBRATE_RIGIDITY": "Decerebrate rigidity", "HP_DEATH_IN_CHILDHOOD": "Death in childhood", "HP_DECREASED_ACHILLES_REFLEX": "Decreased Achilles reflex", "HP_DECREASED_ACTIVITY_OF_MITOCHONDRIAL_ATP_SYNTHASE_COMPLEX": "Decreased activity of mitochondrial ATP synthase complex", "HP_DECREASED_ABSENT_ANKLE_REFLEXES": "Decreased/absent ankle reflexes", "HP_DEATH_IN_INFANCY": "Death in infancy", "HP_DECREASED_ACTIVITY_OF_MITOCHONDRIAL_COMPLEX_II": "Decreased activity of mitochondrial complex II", "HP_DECREASED_ACTIVITY_OF_MITOCHONDRIAL_COMPLEX_I": "Decreased activity of mitochondrial complex I", "HP_DECREASED_ACTIVITY_OF_MITOCHONDRIAL_COMPLEX_III": "Decreased activity of mitochondrial complex III", "HP_DECREASED_ACTIVITY_OF_MITOCHONDRIAL_COMPLEX_IV": "Decreased activity of mitochondrial complex IV", "HP_DECREASED_ACTIVITY_OF_NADPH_OXIDASE": "Decreased activity of NADPH oxidase", "HP_DECREASED_ACTIVITY_OF_THE_PYRUVATE_DEHYDROGENASE_COMPLEX": "Decreased activity of the pyruvate dehydrogenase complex", "HP_DECREASED_AMPLITUDE_OF_SENSORY_ACTION_POTENTIALS": "Decreased amplitude of sensory action potentials", "HP_DECREASED_BODY_MASS_INDEX": "Decreased body mass index", "HP_DECREASED_ADIPOSE_TISSUE": "Decreased adipose tissue", "HP_DECREASED_CALVARIAL_OSSIFICATION": "Decreased calvarial ossification", "HP_DECREASED_BODY_WEIGHT": "", "HP_DECREASED_CD4_CD8_RATIO": "", "HP_DECREASED_CERVICAL_SPINE_FLEXION_DUE_TO_CONTRACTURES_OF_POSTERIOR_CERVICAL_MUSCLES": "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "HP_DECREASED_CERVICAL_SPINE_MOBILITY": "Decreased cervical spine mobility", "HP_DECREASED_CIRCULATING_ACTH_CONCENTRATION": "Decreased circulating ACTH concentration", "HP_DECREASED_CIRCULATING_ADENOSYLCOBALAMIN_CONCENTRATION": "Decreased circulating adenosylcobalamin concentration", "HP_DECREASED_CIRCULATING_ALDOSTERONE_LEVEL": "", "HP_DECREASED_CIRCULATING_ANDROGEN_CONCENTRATION": "Decreased circulating androgen concentration", "HP_DECREASED_CIRCULATING_BETA_2_MICROGLOBULIN_LEVEL": "Decreased circulating beta-2-microglobulin level", "HP_DECREASED_CIRCULATING_ANTIBODY_LEVEL": "", "HP_DECREASED_CIRCULATING_CERULOPLASMIN_CONCENTRATION": "Decreased circulating ceruloplasmin concentration", "HP_DECREASED_CIRCULATING_CARNITINE_CONCENTRATION": "", "HP_DECREASED_CIRCULATING_COMPLEMENT_C3_CONCENTRATION": "Decreased circulating complement C3 concentration", "HP_DECREASED_CIRCULATING_COMPLEMENT_C4_CONCENTRATION": "Decreased circulating complement C4 concentration", "HP_DECREASED_CIRCULATING_COMPLEMENT_FACTOR_I_CONCENTRATION": "Decreased circulating complement factor I concentration", "HP_DECREASED_CIRCULATING_COMPLEMENT_FACTOR_B_CONCENTRATION": "Decreased circulating complement factor B concentration", "HP_DECREASED_CIRCULATING_COPPER_CONCENTRATION": "Decreased circulating copper concentration", "HP_DECREASED_CIRCULATING_CORTISOL_LEVEL": "Decreased circulating cortisol level", "HP_DECREASED_CIRCULATING_DEHYDROEPIANDROSTERONE_CONCENTRATION": "Decreased circulating dehydroepiandrosterone concentration", "HP_DECREASED_CIRCULATING_FREE_T4_CONCENTRATION": "Decreased circulating free T4 concentration", "HP_DECREASED_CIRCULATING_FREE_T3": "Decreased circulating free T3", "HP_DECREASED_CIRCULATING_FOLLICLE_STIMULATING_HORMONE_CONCENTRATION": "Decreased circulating follicle stimulating hormone concentration", "HP_DECREASED_CIRCULATING_IGA_LEVEL": "", "HP_DECREASED_CIRCULATING_IGG2_LEVEL": "", "HP_DECREASED_CIRCULATING_IGE": "", "HP_DECREASED_CIRCULATING_IGG_SUBCLASS_LEVEL": "", "HP_DECREASED_CIRCULATING_GONADOTROPIN_CONCENTRATION": "Decreased circulating gonadotropin concentration", "HP_DECREASED_CIRCULATING_IRON_CONCENTRATION": "Decreased circulating iron concentration", "HP_DECREASED_CIRCULATING_PARATHYROID_HORMONE_LEVEL": "Decreased circulating parathyroid hormone level", "HP_DECREASED_CIRCULATING_METHYLCOBALAMIN_CONCENTRATION": "Decreased circulating methylcobalamin concentration", "HP_DECREASED_CIRCULATING_PREALBUMIN_CONCENTRATION": "Decreased circulating prealbumin concentration", "HP_DECREASED_CIRCULATING_RENIN_LEVEL": "", "HP_DECREASED_CIRCULATING_TERMINAL_COMPLEMENT_COMPONENT_CONCENTRATION": "Decreased circulating terminal complement component concentration", "HP_DECREASED_CIRCULATING_TOTAL_IGA": "Decreased circulating total IgA", "HP_DECREASED_CIRCULATING_TOTAL_IGG": "", "HP_DECREASED_CIRCULATING_VITAMIN_B12_CONCENTRATION": "Decreased circulating vitamin B12 concentration", "HP_DECREASED_CIRCULATING_TOTAL_IGM": "Decreased circulating total IgM", "HP_DECREASED_COMPOUND_MUSCLE_ACTION_POTENTIAL_AMPLITUDE": "Decreased compound muscle action potential amplitude", "HP_DECREASED_CORNEAL_REFLEX": "Decreased corneal reflex", "HP_DECREASED_CIRCULATING_VITAMIN_D_CONCENTRATION": "Decreased circulating vitamin D concentration", "HP_DECREASED_CORNEAL_SENSATION": "Decreased corneal sensation", "HP_DECREASED_DISTAL_SENSORY_NERVE_ACTION_POTENTIAL": "Decreased distal sensory nerve action potential", "HP_DECREASED_EOSINOPHIL_COUNT": "", "HP_DECREASED_DLCO": "Decreased DLCO", "HP_DECREASED_FERTILITY_IN_FEMALES": "Decreased fertility in females", "HP_DECREASED_HIP_ABDUCTION": "Decreased hip abduction", "HP_DECREASED_FERTILITY": "Decreased fertility", "HP_DECREASED_HEAD_CIRCUMFERENCE": "", "HP_DECREASED_FACIAL_EXPRESSION": "Decreased facial expression", "HP_DECREASED_LDL_CHOLESTEROL_CONCENTRATION": "Decreased LDL cholesterol concentration", "HP_DECREASED_LACRIMATION": "Decreased lacrimation", "HP_DECREASED_FERTILITY_IN_MALES": "Decreased fertility in males", "HP_DECREASED_LIGHT_AND_DARK_ADAPTED_ELECTRORETINOGRAM_AMPLITUDE": "Decreased light- and dark-adapted electroretinogram amplitude", "HP_DECREASED_LIBIDO": "Decreased libido", "HP_DECREASED_LYMPHOCYTE_APOPTOSIS": "", "HP_DECREASED_LYMPHOCYTE_PROLIFERATION_IN_RESPONSE_TO_ANTI_CD3": "", "HP_DECREASED_MEAN_CORPUSCULAR_VOLUME": "Decreased mean corpuscular volume", "HP_DECREASED_LYMPHOCYTE_PROLIFERATION_IN_RESPONSE_TO_MITOGEN": "", "HP_DECREASED_METHYLMALONYL_COA_MUTASE_ACTIVITY": "Decreased methylmalonyl-CoA mutase activity", "HP_DECREASED_MEAN_CORPUSCULAR_HEMOGLOBIN_CONCENTRATION": "Decreased mean corpuscular hemoglobin concentration", "HP_DECREASED_NUMBER_OF_LARGE_PERIPHERAL_MYELINATED_NERVE_FIBERS": "Decreased number of large peripheral myelinated nerve fibers", "HP_DECREASED_MINIATURE_ENDPLATE_POTENTIALS": "Decreased miniature endplate potentials", "HP_DECREASED_NASAL_NITRIC_OXIDE": "Decreased nasal nitric oxide", "HP_DECREASED_MUSCLE_MASS": "Decreased muscle mass", "HP_DECREASED_PALMAR_CREASES": "Decreased palmar creases", "HP_DECREASED_PATELLAR_REFLEX": "Decreased patellar reflex", "HP_DECREASED_NUMBER_OF_PERIPHERAL_MYELINATED_NERVE_FIBERS": "Decreased number of peripheral myelinated nerve fibers", "HP_DECREASED_PROPORTION_OF_CD3_POSITIVE_T_CELLS": "", "HP_DECREASED_PROPORTION_OF_NAIVE_T_CELLS": "", "HP_DECREASED_SERUM_CREATININE": "Decreased serum creatinine", "HP_DECREASED_SERUM_LEPTIN": "Decreased serum leptin", "HP_DECREASED_PROPORTION_OF_CD8_POSITIVE_T_CELLS": "", "HP_DECREASED_SERUM_INSULIN_LIKE_GROWTH_FACTOR_1": "", "HP_DECREASED_SIZE_OF_NERVE_TERMINALS": "Decreased size of nerve terminals", "HP_DECREASED_SERUM_ZINC": "Decreased serum zinc", "HP_DECREASED_SKULL_OSSIFICATION": "Decreased skull ossification", "HP_DECREASED_SPECIFIC_ANTIBODY_RESPONSE_TO_POLYSACCHARIDE_VACCINE": "Decreased specific antibody response to polysaccharide vaccine", "HP_DECREASED_SPECIFIC_ANTIBODY_RESPONSE_TO_PROTEIN_CONJUGATED_POLYSACCHARIDE_VACCINE": "Decreased specific antibody response to protein-conjugated polysaccharide vaccine", "HP_DECREASED_SPECIFIC_ANTIBODY_RESPONSE_TO_PROTEIN_VACCINE": "Decreased specific antibody response to protein vaccine", "HP_DECREASED_SPECIFIC_ANTI_POLYSACCHARIDE_ANTIBODY_LEVEL": "Decreased specific anti-polysaccharide antibody level", "HP_DECREASED_SPECIFIC_PNEUMOCOCCAL_ANTIBODY_LEVEL": "Decreased specific pneumococcal antibody level", "HP_DECREASED_SPECIFIC_ANTIBODY_RESPONSE_TO_VACCINATION": "Decreased specific antibody response to vaccination", "HP_DECREASED_THALAMIC_VOLUME": "Decreased thalamic volume", "HP_DECREASED_URINARY_POTASSIUM": "Decreased urinary potassium", "HP_DECREASED_THYROID_STIMULATING_HORMONE_LEVEL": "Decreased thyroid-stimulating hormone level", "HP_DECREASED_TESTICULAR_SIZE": "Decreased testicular size", "HP_DECREASED_VIGILANCE": "Decreased vigilance", "HP_DECREASED_URINE_OUTPUT": "Decreased urine output", "HP_DEEP_PALMAR_CREASE": "Deep palmar crease", "HP_DEEP_PLANTAR_CREASES": "Deep plantar creases", "HP_DEEPLY_SET_EYE": "Deeply set eye", "HP_DEEP_PHILTRUM": "Deep philtrum", "HP_DEEP_VENOUS_THROMBOSIS": "Deep venous thrombosis", "HP_DEEP_SET_NAILS": "Deep-set nails", "HP_DEFECTIVE_DNA_REPAIR_AFTER_ULTRAVIOLET_RADIATION_DAMAGE": "Defective DNA repair after ultraviolet radiation damage", "HP_DEFECTIVE_T_CELL_PROLIFERATION": "", "HP_DEFICIT_IN_GRAMMAR": "Deficit in grammar", "HP_DEFICIENT_EXCISION_OF_UV_INDUCED_PYRIMIDINE_DIMERS_IN_DNA": "Deficient excision of UV-induced pyrimidine dimers in DNA", "HP_DEFICIT_IN_PHONOLOGIC_SHORT_TERM_MEMORY": "Deficit in phonologic short-term memory", "HP_DEFORMED_RIB_CAGE": "Deformed rib cage", "HP_DEFORMED_SELLA_TURCICA": "Deformed sella turcica", "HP_DEFORMED_TARSAL_BONES": "Deformed tarsal bones", "HP_DEGENERATION_OF_THE_STRIATUM": "Degeneration of the striatum", "HP_DEGENERATION_OF_THE_LATERAL_CORTICOSPINAL_TRACTS": "Degeneration of the lateral corticospinal tracts", "HP_DEJA_VU_AURA": "", "HP_DEHYDRATION": "Dehydration", "HP_DELAYED_ABILITY_TO_CRAWL": "Delayed ability to crawl", "HP_DELAYED_ABILITY_TO_ROLL_OVER": "Delayed ability to roll over", "HP_DELAYED_ABILITY_TO_STAND": "Delayed ability to stand", "HP_DELAYED_ABILITY_TO_SIT": "Delayed ability to sit", "HP_DELAYED_BRAINSTEM_AUDITORY_EVOKED_RESPONSE_CONDUCTION_TIME": "Delayed brainstem auditory evoked response conduction time", "HP_DELAYED_CLOSURE_OF_THE_ANTERIOR_FONTANELLE": "Delayed closure of the anterior fontanelle", "HP_DELAYED_CNS_MYELINATION": "Delayed CNS myelination", "HP_DELAYED_CRANIAL_SUTURE_CLOSURE": "Delayed cranial suture closure", "HP_DELAYED_ABILITY_TO_WALK": "Delayed ability to walk", "HP_DELAYED_EARLY_CHILDHOOD_SOCIAL_MILESTONE_DEVELOPMENT": "Delayed early-childhood social milestone development", "HP_DELAYED_ERUPTION_OF_PERMANENT_TEETH": "Delayed eruption of permanent teeth", "HP_DELAYED_EPIPHYSEAL_OSSIFICATION": "Delayed epiphyseal ossification", "HP_DELAYED_ERUPTION_OF_PRIMARY_TEETH": "Delayed eruption of primary teeth", "HP_DELAYED_FINE_MOTOR_DEVELOPMENT": "Delayed fine motor development", "HP_DELAYED_ERUPTION_OF_TEETH": "Delayed eruption of teeth", "HP_DELAYED_MENARCHE": "Delayed menarche", "HP_DELAYED_OSSIFICATION_OF_CARPAL_BONES": "Delayed ossification of carpal bones", "HP_DELAYED_GROSS_MOTOR_DEVELOPMENT": "Delayed gross motor development", "HP_DELAYED_PROXIMAL_FEMORAL_EPIPHYSEAL_OSSIFICATION": "Delayed proximal femoral epiphyseal ossification", "HP_DELAYED_PUBIC_BONE_OSSIFICATION": "Delayed pubic bone ossification", "HP_DELAYED_MYELINATION": "Delayed myelination", "HP_DELAYED_SOMATOSENSORY_CENTRAL_CONDUCTION_TIME": "Delayed somatosensory central conduction time", "HP_DELAYED_UMBILICAL_CORD_SEPARATION": "Delayed umbilical cord separation", "HP_DELIRIUM": "Delirium", "HP_DELAYED_PUBERTY": "Delayed puberty", "HP_DELUSION": "Delusion", "HP_DEMENTIA": "Dementia", "HP_DEMYELINATING_MOTOR_NEUROPATHY": "Demyelinating motor neuropathy", "HP_DENTAL_CROWDING": "Dental crowding", "HP_DEMYELINATING_PERIPHERAL_NEUROPATHY": "Demyelinating peripheral neuropathy", "HP_DEPLETION_OF_MITOCHONDRIAL_DNA_IN_MUSCLE_TISSUE": "", "HP_DENTAL_ENAMEL_PITS": "Dental enamel pits", "HP_DEPOSITS_IMMUNOREACTIVE_TO_BETA_AMYLOID_PROTEIN": "Deposits immunoreactive to beta-amyloid protein", "HP_DEPRESSED_NASAL_TIP": "Depressed nasal tip", "HP_DENTAL_MALOCCLUSION": "Dental malocclusion", "HP_DEPRESSED_NASAL_RIDGE": "Depressed nasal ridge", "HP_DEPRESSED_NASAL_BRIDGE": "Depressed nasal bridge", "HP_DERMAL_ATROPHY": "Dermal atrophy", "HP_DEPRESSION": "Depression", "HP_DERMATAN_SULFATE_EXCRETION_IN_URINE": "Dermatan sulfate excretion in urine", "HP_DERMOID_CYST": "Dermoid cyst", "HP_DERMATOCHALASIS": "Dermatochalasis", "HP_DESMOID_TUMORS": "", "HP_DESCENDING_AORTIC_DISSECTION": "Descending aortic dissection", "HP_DERMAL_TRANSLUCENCY": "Dermal translucency", "HP_DERMATOLOGICAL_MANIFESTATIONS_OF_SYSTEMIC_DISORDERS": "Dermatological manifestations of systemic disorders", "HP_DESQUAMATION_OF_SKIN_SOON_AFTER_BIRTH": "Desquamation of skin soon after birth", "HP_DEVELOPMENTAL_GLAUCOMA": "Developmental glaucoma", "HP_DEVELOPMENTAL_STAGNATION": "Developmental stagnation", "HP_DEVIATION_OF_THE_2ND_FINGER": "Deviation of the 2nd finger", "HP_DEVELOPMENTAL_CATARACT": "Developmental cataract", "HP_DEVIATION_OF_THE_3RD_FINGER": "Deviation of the 3rd finger", "HP_DEVIATED_NASAL_SEPTUM": "Deviated nasal septum", "HP_DEVIATION_OF_THE_2ND_TOE": "Deviation of the 2nd toe", "HP_DEVELOPMENTAL_REGRESSION": "Developmental regression", "HP_DEVIATION_OF_THE_4TH_FINGER": "Deviation of the 4th finger", "HP_DEVIATION_OF_THE_4TH_TOE": "Deviation of the 4th toe", "HP_DEVIATION_OF_THE_5TH_TOE": "Deviation of the 5th toe", "HP_DEVIATION_OF_THE_HALLUX": "Deviation of the hallux", "HP_DEXAMETHASONE_SUPPRESSIBLE_PRIMARY_HYPERALDOSTERONISM": "Dexamethasone-suppressible primary hyperaldosteronism", "HP_DEVIATION_OF_THE_THUMB": "Deviation of the thumb", "HP_DEXTROTRANSPOSITION_OF_THE_GREAT_ARTERIES": "Dextrotransposition of the great arteries", "HP_DIABETIC_KETOACIDOSIS": "Diabetic ketoacidosis", "HP_DEVIATION_OF_TOES": "Deviation of toes", "HP_DEVIATION_OF_THE_HAND_OR_OF_FINGERS_OF_THE_HAND": "Deviation of the hand or of fingers of the hand", "HP_DIABETES_INSIPIDUS": "Diabetes insipidus", "HP_DIAPHRAGMATIC_EVENTRATION": "Diaphragmatic eventration", "HP_DIAPHRAGMATIC_PARALYSIS": "Diaphragmatic paralysis", "HP_DIALEPTIC_SEIZURE": "Dialeptic seizure", "HP_DIAPHRAGMATIC_WEAKNESS": "Diaphragmatic weakness", "HP_DIAPHYSEAL_DYSPLASIA": "Diaphyseal dysplasia", "HP_DIAPHYSEAL_SCLEROSIS": "Diaphyseal sclerosis", "HP_DIAPHYSEAL_UNDERTUBULATION": "Diaphyseal undertubulation", "HP_DIASTEMA": "Diastema", "HP_DIASTASIS_RECTI": "Diastasis recti", "HP_DICARBOXYLIC_ACIDURIA": "Dicarboxylic aciduria", "HP_DIARRHEA": "Diarrhea", "HP_DIFFICULTY_IN_TONGUE_MOVEMENTS": "", "HP_DIFFICULTY_STANDING": "Difficulty standing", "HP_DIFFICULTY_CLIMBING_STAIRS": "Difficulty climbing stairs", "HP_DIFFICULTY_WALKING": "", "HP_DIFFICULTY_RUNNING": "Difficulty running", "HP_DIFFUSE_CEREBELLAR_ATROPHY": "Diffuse cerebellar atrophy", "HP_DIFFUSE_ALVEOLAR_HEMORRHAGE": "Diffuse alveolar hemorrhage", "HP_DIFFUSE_DEMYELINATION_OF_THE_CEREBRAL_WHITE_MATTER": "", "HP_DIFFUSE_CEREBRAL_ATROPHY": "Diffuse cerebral atrophy", "HP_DIFFUSE_OPTIC_DISC_PALLOR": "Diffuse optic disc pallor", "HP_DIFFUSE_MESANGIAL_SCLEROSIS": "Diffuse mesangial sclerosis", "HP_DIFFUSE_PALMOPLANTAR_HYPERKERATOSIS": "Diffuse palmoplantar hyperkeratosis", "HP_DIGENIC_INHERITANCE": "Digenic inheritance", "HP_DIGITAL_FLEXOR_TENOSYNOVITIS": "Digital flexor tenosynovitis", "HP_DIFFUSE_WHITE_MATTER_ABNORMALITIES": "Diffuse white matter abnormalities", "HP_DILATATED_INTERNAL_AUDITORY_CANAL": "Dilatated internal auditory canal", "HP_DILATATION_OF_THE_BLADDER": "Dilatation of the bladder", "HP_DILATATION_OF_THE_CEREBRAL_ARTERY": "Dilatation of the cerebral artery", "HP_DIGESTIVE_SYSTEM_NEOPLASM": "Digestive system neoplasm", "HP_DILATATION_OF_THE_VENTRICULAR_CAVITY": "Dilatation of the ventricular cavity", "HP_DILATION_OF_VIRCHOW_ROBIN_SPACES": "Dilation of Virchow-Robin spaces", "HP_DIMINISHED_ABILITY_TO_CONCENTRATE": "Diminished ability to concentrate", "HP_DIMINISHED_MOTIVATION": "", "HP_DIMPLE_CHIN": "Dimple chin", "HP_DILATED_CARDIOMYOPATHY": "Dilated cardiomyopathy", "HP_DIMINISHED_MOVEMENT": "Diminished movement", "HP_DIPLOPIA": "", "HP_DISINHIBITION": "", "HP_DISPLACEMENT_OF_THE_URETHRAL_MEATUS": "", "HP_DISCOID_LUPUS_RASH": "Discoid lupus rash", "HP_DISPROPORTIONATE_SHORT_TRUNK_SHORT_STATURE": "Disproportionate short-trunk short stature", "HP_DISPROPORTIONATE_SHORT_LIMB_SHORT_STATURE": "Disproportionate short-limb short stature", "HP_DISPROPORTIONATE_SHORT_STATURE": "Disproportionate short stature", "HP_DISPROPORTIONATE_TALL_STATURE": "Disproportionate tall stature", "HP_DISSEMINATED_INTRAVASCULAR_COAGULATION": "Disseminated intravascular coagulation", "HP_DISTAL_ARTHROGRYPOSIS": "Distal arthrogryposis", "HP_DISTAL_JOINT_HYPERMOBILITY": "Distal joint hypermobility", "HP_DISTAL_AMYOTROPHY": "Distal amyotrophy", "HP_DISTAL_LOWER_LIMB_AMYOTROPHY": "Distal lower limb amyotrophy", "HP_DISTAL_LOWER_LIMB_MUSCLE_WEAKNESS": "Distal lower limb muscle weakness", "HP_DISTAL_RENAL_TUBULAR_ACIDOSIS": "Distal renal tubular acidosis", "HP_DISTAL_PERIPHERAL_SENSORY_NEUROPATHY": "Distal peripheral sensory neuropathy", "HP_DISTAL_SENSORY_IMPAIRMENT_OF_ALL_MODALITIES": "Distal sensory impairment of all modalities", "HP_DISTAL_MUSCLE_WEAKNESS": "Distal muscle weakness", "HP_DISTAL_SYMPHALANGISM": "Distal symphalangism", "HP_DISTAL_SENSORY_IMPAIRMENT": "Distal sensory impairment", "HP_DISTICHIASIS": "", "HP_DISTAL_UPPER_LIMB_AMYOTROPHY": "Distal upper limb amyotrophy", "HP_DISTAL_UPPER_LIMB_MUSCLE_WEAKNESS": "Distal upper limb muscle weakness", "HP_DISTURBANCE_DURING_TRANSITIONS_BETWEEN_SLEEP_AND_WAKE_STATES": "", "HP_DISTURBED_PERCEPTION_WITH_A_STIMULUS": "", "HP_DISTURBANCE_OF_FACIAL_EXPRESSION": "Disturbance of facial expression", "HP_DORSOCERVICAL_FAT_PAD": "Dorsocervical fat pad", "HP_DOUBLE_AORTIC_ARCH": "Double aortic arch", "HP_DOWNBEAT_NYSTAGMUS": "Downbeat nystagmus", "HP_DOLICHOCEPHALY": "Dolichocephaly", "HP_DOWN_SLOPING_SHOULDERS": "Down-sloping shoulders", "HP_DROWSINESS": "Drowsiness", "HP_DOWNTURNED_CORNERS_OF_MOUTH": "Downturned corners of mouth", "HP_DRY_HAIR": "Dry hair", "HP_DOWNSLANTED_PALPEBRAL_FISSURES": "Downslanted palpebral fissures", "HP_DRUSEN": "Drusen", "HP_DUANE_ANOMALY": "Duane anomaly", "HP_DUMBBELL_SHAPED_LONG_BONE": "Dumbbell-shaped long bone", "HP_DUODENAL_ADENOCARCINOMA": "Duodenal adenocarcinoma", "HP_DRY_SKIN": "Dry skin", "HP_DUODENAL_ULCER": "Duodenal ulcer", "HP_DUPLICATED_COLLECTING_SYSTEM": "Duplicated collecting system", "HP_DUODENAL_ATRESIA": "Duodenal atresia", "HP_DUPLICATION_OF_PHALANX_OF_TOE": "Duplication of phalanx of toe", "HP_DUPLICATION_OF_RENAL_PELVIS": "Duplication of renal pelvis", "HP_DUPLICATION_INVOLVING_BONES_OF_THE_FEET": "Duplication involving bones of the feet", "HP_DUPLICATION_OF_BONES_INVOLVING_THE_UPPER_EXTREMITIES": "Duplication of bones involving the upper extremities", "HP_DUPLICATION_OF_THE_DISTAL_PHALANX_OF_THE_THUMB": "Duplication of the distal phalanx of the thumb", "HP_DUPLICATION_OF_THE_DISTAL_PHALANX_OF_HAND": "Duplication of the distal phalanx of hand", "HP_DUPLICATION_OF_THUMB_PHALANX": "Duplication of thumb phalanx", "HP_DYNEIN_ARM_DEFECT_OF_RESPIRATORY_MOTILE_CILIA": "Dynein arm defect of respiratory motile cilia", "HP_DYSCALCULIA": "Dyscalculia", "HP_DYSESTHESIA": "Dysesthesia", "HP_DYSDIADOCHOKINESIS": "Dysdiadochokinesis", "HP_DYSGAMMAGLOBULINEMIA": "Dysgammaglobulinemia", "HP_DYSCHROMATOPSIA": "Dyschromatopsia", "HP_DYSGENESIS_OF_THE_CEREBELLAR_VERMIS": "Dysgenesis of the cerebellar vermis", "HP_DYSGENESIS_OF_THE_BASAL_GANGLIA": "Dysgenesis of the basal ganglia", "HP_DYSARTHRIA": "Dysarthria", "HP_DYSGENESIS_OF_THE_HIPPOCAMPUS": "Dysgenesis of the hippocampus", "HP_DYSGERMINOMA": "Dysgerminoma", "HP_DYSGRAPHIA": "Dysgraphia", "HP_DYSGYRIA": "Dysgyria", "HP_DYSLEXIA": "Dyslexia", "HP_DYSMENORRHEA": "Dysmenorrhea", "HP_DYSOSTOSIS_MULTIPLEX": "Dysostosis multiplex", "HP_DYSMETRIC_SACCADES": "Dysmetric saccades", "HP_DYSKINESIA": "Dyskinesia", "HP_DYSMETRIA": "Dysmetria", "HP_DYSPLASIA_OF_THE_FEMORAL_HEAD": "Dysplasia of the femoral head", "HP_DYSPAREUNIA": "Dyspareunia", "HP_DYSPHONIA": "Dysphonia", "HP_DYSPLASTIC_CORPUS_CALLOSUM": "Dysplastic corpus callosum", "HP_DYSTROPHIC_TOENAIL": "Dystrophic toenail", "HP_DYSTROPHIC_FINGERNAILS": "Dystrophic fingernails", "HP_DYSURIA": "Dysuria", "HP_DYSPHAGIA": "Dysphagia", "HP_DYSPNEA": "Dyspnea", "HP_EARLY_SATIETY": "Early satiety", "HP_DYSTONIA": "Dystonia", "HP_EAR_PAIN": "Ear pain", "HP_EARLY_ONSET_OF_SEXUAL_MATURATION": "Early onset of sexual maturation", "HP_EARLY_YOUNG_ADULT_ONSET": "Early young adult onset", "HP_EBSTEIN_ANOMALY_OF_THE_TRICUSPID_VALVE": "Ebstein anomaly of the tricuspid valve", "HP_EASY_FATIGABILITY": "Easy fatigability", "HP_ECHOGENIC_FETAL_BOWEL": "Echogenic fetal bowel", "HP_ECLAMPSIA": "Eclampsia", "HP_ECCHYMOSIS": "Ecchymosis", "HP_ECTODERMAL_DYSPLASIA": "Ectodermal dysplasia", "HP_ECLABION": "Eclabion", "HP_ECTOPIA_PUPILLAE": "Ectopia pupillae", "HP_ECTOPIA_LENTIS": "Ectopia lentis", "HP_ECTOPIC_ANTERIOR_PITUITARY_GLAND": "Ectopic anterior pituitary gland", "HP_ECTOPIC_ANUS": "Ectopic anus", "HP_ECTOPIC_THYROID": "", "HP_ECTOPIC_KIDNEY": "Ectopic kidney", "HP_ECTRODACTYLY": "Ectrodactyly", "HP_ECTOPIC_CALCIFICATION": "Ectopic calcification", "HP_ECTROPION": "Ectropion", "HP_ECTROPION_OF_LOWER_EYELIDS": "Ectropion of lower eyelids", "HP_EDEMA_OF_THE_DORSUM_OF_HANDS": "Edema of the dorsum of hands", "HP_EDEMA_OF_THE_DORSUM_OF_FEET": "Edema of the dorsum of feet", "HP_ECZEMATOID_DERMATITIS": "Eczematoid dermatitis", "HP_EEG_WITH_ABNORMALLY_SLOW_FREQUENCIES": "EEG with abnormally slow frequencies", "HP_EEG_WITH_CENTROTEMPORAL_EPILEPTIFORM_DISCHARGES": "EEG with centrotemporal epileptiform discharges", "HP_EEG_WITH_BURST_SUPPRESSION": "EEG with burst suppression", "HP_EEG_WITH_CONTINUOUS_SLOW_ACTIVITY": "EEG with continuous slow activity", "HP_EEG_WITH_FOCAL_SHARP_SLOW_WAVES": "EEG with focal sharp slow waves", "HP_EEG_WITH_FOCAL_SHARP_WAVES": "EEG with focal sharp waves", "HP_EEG_WITH_FOCAL_EPILEPTIFORM_DISCHARGES": "EEG with focal epileptiform discharges", "HP_EEG_WITH_FOCAL_SPIKES": "EEG with focal spikes", "HP_EEG_WITH_FRONTAL_EPILEPTIFORM_DISCHARGES": "EEG with frontal epileptiform discharges", "HP_EEG_WITH_FOCAL_SPIKE_WAVES": "EEG with focal spike waves", "HP_EEG_WITH_FRONTAL_FOCAL_SPIKES": "EEG with frontal focal spikes", "HP_EEG_WITH_GENERALIZED_POLYSPIKES": "EEG with generalized polyspikes", "HP_EEG_WITH_GENERALIZED_SHARP_SLOW_WAVES": "EEG with generalized sharp slow waves", "HP_EEG_WITH_GENERALIZED_SLOW_ACTIVITY": "EEG with generalized slow activity", "HP_EEG_WITH_GENERALIZED_SLOW_ACTIVITY_GRADE_4": "", "HP_EEG_WITH_GENERALIZED_EPILEPTIFORM_DISCHARGES": "EEG with generalized epileptiform discharges", "HP_EEG_WITH_IRREGULAR_GENERALIZED_SPIKE_AND_WAVE_COMPLEXES": "EEG with irregular generalized spike and wave complexes", "HP_EEG_WITH_PARIETAL_EPILEPTIFORM_DISCHARGES": "EEG with parietal epileptiform discharges", "HP_EEG_WITH_PHOTOPAROXYSMAL_RESPONSE": "EEG with photoparoxysmal response", "HP_EEG_WITH_MULTIFOCAL_SLOW_ACTIVITY": "EEG with multifocal slow activity", "HP_EEG_WITH_POLYSPIKE_WAVE_COMPLEXES": "EEG with polyspike wave complexes", "HP_EEG_WITH_SERIES_OF_FOCAL_SPIKES": "", "HP_EEG_WITH_SPIKE_WAVE_COMPLEXES_2_5_3_5_HZ": "EEG with spike-wave complexes (2.5-3.5 Hz)", "HP_ELBOW_ANKYLOSIS": "Elbow ankylosis", "HP_ELEVATED_ALKALINE_PHOSPHATASE_OF_BONE_ORIGIN": "Elevated alkaline phosphatase of bone origin", "HP_EEG_WITH_SPIKE_WAVE_COMPLEXES": "EEG with spike-wave complexes", "HP_ELBOW_CONTRACTURE": "Elbow contracture", "HP_ELEVATED_BRAIN_CHOLINE_LEVEL_BY_MRS": "Elevated brain choline level by MRS", "HP_ELEVATED_BRONCHOALVEOLAR_LAVAGE_FLUID_NEUTROPHIL_PROPORTION": "Elevated bronchoalveolar lavage fluid neutrophil proportion", "HP_ELEVATED_CIRCULATING_ACYLCARNITINE_CONCENTRATION": "Elevated circulating acylcarnitine concentration", "HP_ELEVATED_CIRCULATING_ALDOLASE_CONCENTRATION": "Elevated circulating aldolase concentration", "HP_ELEVATED_CIRCULATING_CALCITONIN_CONCENTRATION": "", "HP_ELEVATED_CIRCULATING_ASPARTATE_AMINOTRANSFERASE_CONCENTRATION": "Elevated circulating aspartate aminotransferase concentration", "HP_ELEVATED_CIRCULATING_ALANINE_AMINOTRANSFERASE_CONCENTRATION": "Elevated circulating alanine aminotransferase concentration", "HP_ELEVATED_CIRCULATING_CATECHOLAMINE_LEVEL": "", "HP_ELEVATED_CIRCULATING_GLUTARIC_ACID_CONCENTRATION": "Elevated circulating glutaric acid concentration", "HP_ELEVATED_CIRCULATING_GROWTH_HORMONE_CONCENTRATION": "Elevated circulating growth hormone concentration", "HP_ELEVATED_CIRCULATING_FOLLICLE_STIMULATING_HORMONE_LEVEL": "Elevated circulating follicle stimulating hormone level", "HP_ELEVATED_CIRCULATING_CREATINE_KINASE_CONCENTRATION": "Elevated circulating creatine kinase concentration", "HP_ELEVATED_CIRCULATING_LONG_CHAIN_FATTY_ACID_CONCENTRATION": "Elevated circulating long chain fatty acid concentration", "HP_ELEVATED_CIRCULATING_HEPATIC_TRANSAMINASE_CONCENTRATION": "Elevated circulating hepatic transaminase concentration", "HP_ELEVATED_CIRCULATING_PARATHYROID_HORMONE_LEVEL": "Elevated circulating parathyroid hormone level", "HP_ELEVATED_CIRCULATING_PHYTANIC_ACID_CONCENTRATION": "Elevated circulating phytanic acid concentration", "HP_ELEVATED_CIRCULATING_LUTEINIZING_HORMONE_LEVEL": "Elevated circulating luteinizing hormone level", "HP_ELEVATED_CREATINE_KINASE_AFTER_EXERCISE": "Elevated creatine kinase after exercise", "HP_ELEVATED_CIRCULATING_THYROID_STIMULATING_HORMONE_CONCENTRATION": "Elevated circulating thyroid-stimulating hormone concentration", "HP_ELEVATED_HEMOGLOBIN_A1C": "Elevated hemoglobin A1c", "HP_ELEVATED_HEPATIC_IRON_CONCENTRATION": "Elevated hepatic iron concentration", "HP_ELEVATED_MATERNAL_CIRCULATING_ALPHA_FETOPROTEIN_CONCENTRATION": "Elevated maternal circulating alpha-fetoprotein concentration", "HP_ELEVATED_LACTATE_PYRUVATE_RATIO": "Elevated lactate:pyruvate ratio", "HP_ELEVATED_SERUM_ANION_GAP": "Elevated serum anion gap", "HP_ELEVATED_SERUM_11_DEOXYCORTISOL": "Elevated serum 11-deoxycortisol", "HP_ELEVATED_SERUM_ACID_PHOSPHATASE": "Elevated serum acid phosphatase", "HP_ELEVATED_MEAN_ARTERIAL_PRESSURE": "Elevated mean arterial pressure", "HP_ELEVATED_TISSUE_NON_SPECIFIC_ALKALINE_PHOSPHATASE": "Elevated tissue non-specific alkaline phosphatase", "HP_ELEVATED_SYSTOLIC_BLOOD_PRESSURE": "", "HP_ELEVATED_TOTAL_SERUM_TRYPTASE": "Elevated total serum tryptase", "HP_ELEVATED_TRANSFERRIN_SATURATION": "Elevated transferrin saturation", "HP_ELEVATED_URINARY_3_HYDROXYBUTYRIC_ACID": "Elevated urinary 3-hydroxybutyric acid", "HP_ELEVATED_URINARY_CARBOXYLIC_ACID": "Elevated urinary carboxylic acid", "HP_ELEVATED_URINARY_CATECHOLAMINE_LEVEL": "", "HP_ELEVATED_URINARY_COLLAGEN_DEGRADATION_PRODUCTS": "Elevated urinary collagen degradation products", "HP_ELEVATED_URINARY_DELTA_AMINOLEVULINIC_ACID": "Elevated urinary delta-aminolevulinic acid", "HP_ELEVATED_URINARY_HOMOVANILLIC_ACID": "Elevated urinary homovanillic acid", "HP_ELEVATED_URINARY_MONOCARBOXYLIC_ACID_LEVEL": "Elevated urinary monocarboxylic acid level", "HP_ELEVATED_URINARY_NOREPINEPHRINE_LEVEL": "Elevated urinary norepinephrine level", "HP_ELEVATED_URINARY_VANILLYLMANDELIC_ACID": "Elevated urinary vanillylmandelic acid", "HP_ELFIN_FACIES": "Elfin facies", "HP_ELONGATED_SUPERIOR_CEREBELLAR_PEDUNCLE": "Elongated superior cerebellar peduncle", "HP_ELLIPTOCYTOSIS": "Elliptocytosis", "HP_EMG_AXONAL_ABNORMALITY": "EMG: axonal abnormality", "HP_EMBRYONAL_RENAL_NEOPLASM": "Embryonal renal neoplasm", "HP_EMG_ABNORMALITY": "EMG abnormality", "HP_EMBRYONAL_NEOPLASM": "Embryonal neoplasm", "HP_EMG_CHRONIC_DENERVATION_SIGNS": "EMG: chronic denervation signs", "HP_EMG_MYOTONIC_DISCHARGES": "EMG: myotonic discharges", "HP_EMG_MYOPATHIC_ABNORMALITIES": "EMG: myopathic abnormalities", "HP_EMG_DECREMENTAL_RESPONSE_OF_COMPOUND_MUSCLE_ACTION_POTENTIAL_TO_REPETITIVE_NERVE_STIMULATION": "EMG: decremental response of compound muscle action potential to repetitive nerve stimulation", "HP_EMG_IMPAIRED_NEUROMUSCULAR_TRANSMISSION": "EMG: impaired neuromuscular transmission", "HP_EMG_NEUROPATHIC_CHANGES": "EMG: neuropathic changes", "HP_EMG_POSITIVE_SHARP_WAVES": "EMG: positive sharp waves", "HP_EMG_SLOW_MOTOR_CONDUCTION": "EMG: slow motor conduction", "HP_EMOTIONAL_LABILITY": "", "HP_ENAMEL_HYPOMINERALIZATION": "Enamel hypomineralization", "HP_EMPHYSEMA": "Emphysema", "HP_ENAMEL_HYPOPLASIA": "Enamel hypoplasia", "HP_ENCEPHALOMALACIA": "Encephalomalacia", "HP_ENDOCARDIAL_FIBROELASTOSIS": "Endocardial fibroelastosis", "HP_ENCEPHALOCELE": "Encephalocele", "HP_ENCHONDROMA": "Enchondroma", "HP_ENDOCARDIAL_FIBROSIS": "Endocardial fibrosis", "HP_ENLARGED_CEREBELLUM": "Enlarged cerebellum", "HP_ENDOCARDITIS": "Endocarditis", "HP_ENCEPHALOPATHY": "Encephalopathy", "HP_ENLARGED_EPIPHYSES": "Enlarged epiphyses", "HP_ENLARGED_CISTERNA_MAGNA": "Enlarged cisterna magna", "HP_ENLARGED_INTERPHALANGEAL_JOINTS": "Enlarged interphalangeal joints", "HP_ENLARGED_METAPHYSES": "Enlarged metaphyses", "HP_ENLARGED_JOINTS": "Enlarged joints", "HP_ENLARGED_NARIS": "Enlarged naris", "HP_ENLARGED_KIDNEY": "Enlarged kidney", "HP_ENLARGED_OVARIES": "Enlarged ovaries", "HP_ENLARGED_VESTIBULAR_AQUEDUCT": "Enlarged vestibular aqueduct", "HP_ENLARGED_POSTERIOR_FOSSA": "Enlarged posterior fossa", "HP_ENLARGED_TONSILS": "Enlarged tonsils", "HP_ENLARGED_THORAX": "Enlarged thorax", "HP_ENLARGEMENT_OF_THE_ANKLES": "Enlargement of the ankles", "HP_ENLARGEMENT_OF_THE_COSTOCHONDRAL_JUNCTION": "Enlargement of the costochondral junction", "HP_ENLARGEMENT_OF_THE_WRISTS": "Enlargement of the wrists", "HP_ENTEROCOLITIS": "Enterocolitis", "HP_ENTRAPMENT_NEUROPATHY": "Entrapment neuropathy", "HP_ENTHESITIS": "Enthesitis", "HP_ENTROPION": "Entropion", "HP_ENURESIS": "Enuresis", "HP_ENURESIS_NOCTURNA": "Enuresis nocturna", "HP_EOSINOPHILIA": "", "HP_EPENDYMOMA": "Ependymoma", "HP_EOSINOPHILIC_INFILTRATION_OF_THE_ESOPHAGUS": "Eosinophilic infiltration of the esophagus", "HP_EPIBLEPHARON": "Epiblepharon", "HP_EPICANTHUS_INVERSUS": "Epicanthus inversus", "HP_EPIDERMAL_ACANTHOSIS": "Epidermal acanthosis", "HP_EPIDERMAL_HYPERKERATOSIS": "", "HP_EPIDERMAL_NEVUS": "Epidermal nevus", "HP_EPIDIDYMITIS": "Epididymitis", "HP_EPIDERMOID_CYST": "Epidermoid cyst", "HP_EPICANTHUS": "Epicanthus", "HP_EPIDURAL_HEMORRHAGE": "Epidural hemorrhage", "HP_EPIGASTRIC_PAIN": "Epigastric pain", "HP_EPILEPTIC_AURA": "Epileptic aura", "HP_EPILEPSIA_PARTIALIS_CONTINUA": "Epilepsia partialis continua", "HP_EPILEPTIC_ENCEPHALOPATHY": "Epileptic encephalopathy", "HP_EPIPHORA": "Epiphora", "HP_EPILEPTIC_SPASM": "Epileptic spasm", "HP_EPIPHYSEAL_DYSPLASIA": "Epiphyseal dysplasia", "HP_EPIRETINAL_MEMBRANE": "Epiretinal membrane", "HP_EPIPHYSEAL_STIPPLING": "Epiphyseal stippling", "HP_EPISCLERITIS": "Episcleritis", "HP_EPISODIC_ATAXIA": "Episodic ataxia", "HP_EPISODIC_FLACCID_WEAKNESS": "Episodic flaccid weakness", "HP_EPISODIC_HYPERHIDROSIS": "Episodic hyperhidrosis", "HP_EPISODIC_HYPERTENSION": "Episodic hypertension", "HP_EPISODIC_HYPOKALEMIA": "Episodic hypokalemia", "HP_EPISODIC_METABOLIC_ACIDOSIS": "Episodic metabolic acidosis", "HP_EPISODIC_PAIN": "Episodic pain", "HP_EPISODIC_RESPIRATORY_DISTRESS": "Episodic respiratory distress", "HP_EPISODIC_TACHYPNEA": "Episodic tachypnea", "HP_EPISPADIAS": "Epispadias", "HP_EPISODIC_VOMITING": "Episodic vomiting", "HP_ERLENMEYER_FLASK_DEFORMITY_OF_THE_FEMURS": "Erlenmeyer flask deformity of the femurs", "HP_EQUINOVARUS_DEFORMITY": "Equinovarus deformity", "HP_ERECTILE_DYSFUNCTION": "Erectile dysfunction", "HP_EQUINUS_CALCANEUS": "Equinus calcaneus", "HP_EPISTAXIS": "Epistaxis", "HP_ERRATIC_MYOCLONUS": "Erratic myoclonus", "HP_EROSION_OF_ORAL_MUCOSA": "Erosion of oral mucosa", "HP_ERYTHEMA": "Erythema", "HP_ERYSIPELAS": "Erysipelas", "HP_ERUPTION_FAILURE": "Eruption failure", "HP_ERYTHEMATOUS_PLAQUE": "Erythematous plaque", "HP_ERYTHROCYTE_INCLUSION_BODIES": "Erythrocyte inclusion bodies", "HP_ERYTHEMA_NODOSUM": "Erythema nodosum", "HP_ERYTHEMATOUS_PAPULE": "Erythematous papule", "HP_ERYTHROID_DYSPLASIA": "Erythroid dysplasia", "HP_ERYTHROID_HYPERPLASIA": "Erythroid hyperplasia", "HP_ERYTHRODERMA": "Erythroderma", "HP_ERYTHROID_HYPOPLASIA": "Erythroid hypoplasia", "HP_ERYTHROMELALGIA": "Erythromelalgia", "HP_ESOPHAGEAL_ATRESIA": "Esophageal atresia", "HP_ESOPHAGEAL_CARCINOMA": "Esophageal carcinoma", "HP_ESOPHAGEAL_NEOPLASM": "Esophageal neoplasm", "HP_ESOPHAGEAL_STENOSIS": "Esophageal stenosis", "HP_ESODEVIATION": "Esodeviation", "HP_ESOPHAGEAL_STRICTURE": "Esophageal stricture", "HP_ESOPHAGEAL_ULCERATION": "Esophageal ulceration", "HP_ESOPHAGEAL_VARIX": "Esophageal varix", "HP_ESOPHORIA": "Esophoria", "HP_ESOPHAGITIS": "Esophagitis", "HP_ETHYLMALONIC_ACIDURIA": "Ethylmalonic aciduria", "HP_EUNUCHOID_HABITUS": "Eunuchoid habitus", "HP_EURYBLEPHARON": "Euryblepharon", "HP_EUTHYROID_GOITER": "Euthyroid goiter", "HP_EVERSION_OF_LATERAL_THIRD_OF_LOWER_EYELIDS": "Eversion of lateral third of lower eyelids", "HP_EVERTED_UPPER_LIP_VERMILION": "Everted upper lip vermilion", "HP_EVERTED_LOWER_LIP_VERMILION": "Everted lower lip vermilion", "HP_EXANTHEM": "Exanthem", "HP_EXAGGERATED_STARTLE_RESPONSE": "Exaggerated startle response", "HP_EXCESSIVE_BLEEDING_FROM_SUPERFICIAL_CUTS": "Excessive bleeding from superficial cuts", "HP_EXAGGERATED_CUPID_S_BOW": "Exaggerated cupid's bow", "HP_EXCESSIVE_DAYTIME_SOMNOLENCE": "Excessive daytime somnolence", "HP_EXCESSIVE_SHYNESS": "Excessive shyness", "HP_EXCESSIVE_WRINKLING_OF_PALMAR_SKIN": "Excessive wrinkling of palmar skin", "HP_EXCESSIVE_SALIVATION": "Excessive salivation", "HP_EXERCISE_INDUCED_MUSCLE_CRAMPS": "Exercise-induced muscle cramps", "HP_EXCESSIVE_WRINKLED_SKIN": "Excessive wrinkled skin", "HP_EXERCISE_INDUCED_MUSCLE_FATIGUE": "Exercise-induced muscle fatigue", "HP_EXERCISE_INDUCED_MUSCLE_STIFFNESS": "Exercise-induced muscle stiffness", "HP_EXERCISE_INDUCED_MYOGLOBINURIA": "Exercise-induced myoglobinuria", "HP_EXERCISE_INDUCED_MYALGIA": "Exercise-induced myalgia", "HP_EXERCISE_INDUCED_RHABDOMYOLYSIS": "Exercise-induced rhabdomyolysis", "HP_EXOSTOSES": "Exostoses", "HP_EXOPHORIA": "Exophoria", "HP_EXERCISE_INTOLERANCE": "Exercise intolerance", "HP_EXERTIONAL_DYSPNEA": "Exertional dyspnea", "HP_EXODEVIATION": "Exodeviation", "HP_EXPRESSIVE_APHASIA": "Expressive aphasia", "HP_EXSTROPHY": "", "HP_EXPRESSIVE_LANGUAGE_DELAY": "Expressive language delay", "HP_EXTRAHEPATIC_CHOLESTASIS": "Extrahepatic cholestasis", "HP_EXTERNAL_OPHTHALMOPLEGIA": "External ophthalmoplegia", "HP_EXTRAPYRAMIDAL_DYSKINESIA": "Extrapyramidal dyskinesia", "HP_EXTRAMEDULLARY_HEMATOPOIESIS": "Extramedullary hematopoiesis", "HP_EXTERNAL_GENITAL_HYPOPLASIA": "External genital hypoplasia", "HP_EXTRA_AXIAL_CEREBROSPINAL_FLUID_ACCUMULATION": "Extra-axial cerebrospinal fluid accumulation", "HP_EXTRAPYRAMIDAL_MUSCULAR_RIGIDITY": "Extrapyramidal muscular rigidity", "HP_EXUDATIVE_VITREORETINOPATHY": "Exudative vitreoretinopathy", "HP_EYELID_APRAXIA": "Eyelid apraxia", "HP_EXUDATIVE_RETINAL_DETACHMENT": "", "HP_EYELID_COLOBOMA": "Eyelid coloboma", "HP_EYELID_MYOCLONIA_SEIZURE": "Eyelid myoclonia seizure", "HP_EYELID_MYOCLONUS": "Eyelid myoclonus", "HP_EYE_MOVEMENT_INDUCED_PAIN": "Eye movement-induced pain", "HP_EYE_OF_THE_TIGER_ANOMALY_OF_GLOBUS_PALLIDUS": "Eye of the tiger anomaly of globus pallidus", "HP_EYE_POKING": "Eye poking", "HP_FACIAL_CAPILLARY_HEMANGIOMA": "Facial capillary hemangioma", "HP_FACIAL_ERYTHEMA": "Facial erythema", "HP_FACIAL_DIPLEGIA": "Facial diplegia", "HP_FACIAL_ASYMMETRY": "Facial asymmetry", "HP_FACIAL_EDEMA": "Facial edema", "HP_FACIAL_GRIMACING": "Facial grimacing", "HP_FACIAL_HEMANGIOMA": "Facial hemangioma", "HP_FACIAL_HYPEROSTOSIS": "Facial hyperostosis", "HP_FACIAL_MYOKYMIA": "Facial myokymia", "HP_FACIAL_HYPERTRICHOSIS": "Facial hypertrichosis", "HP_FACIAL_HYPOTONIA": "Facial hypotonia", "HP_FACIAL_PARALYSIS": "Facial paralysis", "HP_FACIAL_SHAPE_DEFORMATION": "Facial shape deformation", "HP_FACIAL_TICS": "Facial tics", "HP_FACIAL_TELANGIECTASIA": "Facial telangiectasia", "HP_FAILURE_OF_ERUPTION_OF_PERMANENT_TEETH": "Failure of eruption of permanent teeth", "HP_FAILURE_TO_THRIVE_SECONDARY_TO_RECURRENT_INFECTIONS": "Failure to thrive secondary to recurrent infections", "HP_FAILURE_TO_THRIVE_IN_INFANCY": "Failure to thrive in infancy", "HP_FAIR_HAIR": "Fair hair", "HP_FALCIFORM_RETINAL_FOLD": "Falciform retinal fold", "HP_FASTING_HYPOGLYCEMIA": "Fasting hypoglycemia", "HP_FALLS": "Falls", "HP_FAILURE_TO_THRIVE": "Failure to thrive", "HP_FASTING_HYPERINSULINEMIA": "Fasting hyperinsulinemia", "HP_FASCICULATIONS": "Fasciculations", "HP_FATIGABLE_WEAKNESS_OF_BULBAR_MUSCLES": "Fatigable weakness of bulbar muscles", "HP_FATIGABLE_WEAKNESS_OF_DISTAL_LIMB_MUSCLES": "Fatigable weakness of distal limb muscles", "HP_FATIGABLE_WEAKNESS_OF_RESPIRATORY_MUSCLES": "Fatigable weakness of respiratory muscles", "HP_FATIGABLE_WEAKNESS_OF_SKELETAL_MUSCLES": "Fatigable weakness of skeletal muscles", "HP_FATIGABLE_WEAKNESS_OF_SWALLOWING_MUSCLES": "Fatigable weakness of swallowing muscles", "HP_FATIGUABLE_WEAKNESS_OF_PROXIMAL_LIMB_MUSCLES": "Fatiguable weakness of proximal limb muscles", "HP_FAVORABLE_RESPONSE_OF_WEAKNESS_TO_ACETYLCHOLINE_ESTERASE_INHIBITORS": "Favorable response of weakness to acetylcholine esterase inhibitors", "HP_FATTY_REPLACEMENT_OF_SKELETAL_MUSCLE": "Fatty replacement of skeletal muscle", "HP_FEBRILE_SEIZURE_WITHIN_THE_AGE_RANGE_OF_3_MONTHS_TO_6_YEARS": "Febrile seizure (within the age range of 3 months to 6 years)", "HP_FEMALE_EXTERNAL_GENITALIA_IN_INDIVIDUAL_WITH_46_XY_KARYOTYPE": "Female external genitalia in individual with 46,XY karyotype", "HP_FEMALE_PSEUDOHERMAPHRODITISM": "Female pseudohermaphroditism", "HP_FEMALE_HYPOGONADISM": "Female hypogonadism", "HP_FATIGUE": "Fatigue", "HP_FEMALE_INFERTILITY": "Female infertility", "HP_FEEDING_DIFFICULTIES_IN_INFANCY": "Feeding difficulties in infancy", "HP_FEEDING_DIFFICULTIES": "Feeding difficulties", "HP_FEMALE_REPRODUCTIVE_SYSTEM_NEOPLASM": "Female reproductive system neoplasm", "HP_FEMALE_SEXUAL_DYSFUNCTION": "Female sexual dysfunction", "HP_FEMORAL_BOWING": "Femoral bowing", "HP_FEMORAL_HERNIA": "Femoral hernia", "HP_FEMUR_FRACTURE": "Femur fracture", "HP_FETAL_AKINESIA_SEQUENCE": "Fetal akinesia sequence", "HP_FETAL_ASCITES": "Fetal ascites", "HP_FETAL_NECK_ANOMALY": "Fetal neck anomaly", "HP_FETAL_DISTRESS": "Fetal distress", "HP_FETAL_PERICARDIAL_EFFUSION": "Fetal pericardial effusion", "HP_FETAL_ANOMALY": "Fetal anomaly", "HP_FETAL_PLEURAL_EFFUSION": "Fetal pleural effusion", "HP_FETAL_POLYURIA": "Fetal polyuria", "HP_FETAL_PYELECTASIS": "Fetal pyelectasis", "HP_FETAL_ONSET": "Fetal onset", "HP_FETAL_ULTRASOUND_SOFT_MARKER": "Fetal ultrasound soft marker", "HP_FEW_CAFE_AU_LAIT_SPOTS": "Few cafe-au-lait spots", "HP_FIBER_TYPE_GROUPING": "Fiber type grouping", "HP_FIBROADENOMA_OF_THE_BREAST": "Fibroadenoma of the breast", "HP_FIBULAR_APLASIA": "Fibular aplasia", "HP_FEVER": "Fever", "HP_FIBROUS_TISSUE_NEOPLASM": "Fibrous tissue neoplasm", "HP_FIBULAR_BOWING": "Fibular bowing", "HP_FIBULAR_HYPOPLASIA": "Fibular hypoplasia", "HP_FIFTH_FINGER_DISTAL_PHALANX_CLINODACTYLY": "Fifth finger distal phalanx clinodactyly", "HP_FINGERNAIL_DYSPLASIA": "Fingernail dysplasia", "HP_FINE_HAIR": "Fine hair", "HP_FIBROSARCOMA": "", "HP_FINGER_SWELLING": "Finger swelling", "HP_FINGER_SYMPHALANGISM": "", "HP_FINGER_APLASIA": "Finger aplasia", "HP_FIRST_DORSAL_INTEROSSEI_MUSCLE_WEAKNESS": "First dorsal interossei muscle weakness", "HP_FIRST_DEGREE_ATRIOVENTRICULAR_BLOCK": "First degree atrioventricular block", "HP_FINGER_SYNDACTYLY": "Finger syndactyly", "HP_FLARED_ILIAC_WING": "Flared iliac wing", "HP_FLANK_PAIN": "Flank pain", "HP_FINGER_CLINODACTYLY": "Finger clinodactyly", "HP_FLARED_LOWER_LIMB_METAPHYSIS": "Flared lower limb metaphysis", "HP_FLARED_NOSTRILS": "Flared nostrils", "HP_FLARING_OF_RIB_CAGE": "Flaring of rib cage", "HP_FLARED_METAPHYSIS": "Flared metaphysis", "HP_FLATTENED_EPIPHYSIS": "Flattened epiphysis", "HP_FLATTENED_FEMORAL_EPIPHYSIS": "Flattened femoral epiphysis", "HP_FLATTENED_FEMORAL_HEAD": "Flattened femoral head", "HP_FLAT_CORNEA": "Flat cornea", "HP_FLAT_ACETABULAR_ROOF": "Flat acetabular roof", "HP_FLAT_FOREHEAD": "Flat forehead", "HP_FLAT_FACE": "Flat face", "HP_FLAT_NASAL_ALAE": "Flat nasal alae", "HP_FLEXION_CONTRACTURE_OF_THE_2ND_FINGER": "", "HP_FLAT_OCCIPUT": "Flat occiput", "HP_FLUCTUATIONS_IN_CONSCIOUSNESS": "Fluctuations in consciousness", "HP_FOAM_CELLS": "Foam cells", "HP_FLUSHING": "Flushing", "HP_FOAMY_URINE": "", "HP_FOCAL_AUTONOMIC_SEIZURE": "Focal autonomic seizure", "HP_FLEXION_CONTRACTURE_OF_DIGIT": "Flexion contracture of digit", "HP_FOCAL_AUTOMATISM_SEIZURE": "Focal automatism seizure", "HP_FOCAL_AWARE_SEIZURE": "Focal aware seizure", "HP_FOCAL_CORTICAL_DYSPLASIA_TYPE_II": "Focal cortical dysplasia type II", "HP_FOCAL_CLONIC_SEIZURE": "Focal clonic seizure", "HP_FOCAL_CORTICAL_DYSPLASIA": "Focal cortical dysplasia", "HP_FOCAL_HEMICLONIC_SEIZURE": "Focal hemiclonic seizure", "HP_FOCAL_DYSTONIA": "Focal dystonia", "HP_FOCAL_EMOTIONAL_SEIZURE": "Focal emotional seizure", "HP_FOCAL_HEAD_NODDING_AUTOMATISM_SEIZURE": "", "HP_FOCAL_MOTOR_STATUS_EPILEPTICUS": "Focal motor status epilepticus", "HP_FOCAL_MOTOR_SEIZURE": "Focal motor seizure", "HP_FOCAL_MYOCLONIC_SEIZURE": "Focal myoclonic seizure", "HP_FOCAL_IMPAIRED_AWARENESS_SEIZURE": "Focal impaired awareness seizure", "HP_FOCAL_NON_MOTOR_SEIZURE": "Focal non-motor seizure", "HP_FOCAL_SENSORY_SEIZURE": "Focal sensory seizure", "HP_FOCAL_SENSORY_SEIZURE_WITH_VISUAL_FEATURES": "Focal sensory seizure with visual features", "HP_FOCAL_T2_HYPERINTENSE_BASAL_GANGLIA_LESION": "Focal T2 hyperintense basal ganglia lesion", "HP_FOCAL_ONSET_SEIZURE": "Focal-onset seizure", "HP_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS": "Focal segmental glomerulosclerosis", "HP_FOCAL_T2_HYPERINTENSE_BRAINSTEM_LESION": "Focal T2 hyperintense brainstem lesion", "HP_FOCAL_T2_HYPERINTENSE_THALAMIC_LESION": "", "HP_FOCAL_WHITE_MATTER_LESIONS": "Focal white matter lesions", "HP_FOCAL_TONIC_SEIZURE": "Focal tonic seizure", "HP_FOLLICULAR_HYPERKERATOSIS": "Follicular hyperkeratosis", "HP_FOLLICULAR_HYPERPLASIA": "Follicular hyperplasia", "HP_FOOD_INTOLERANCE": "Food intolerance", "HP_FOOD_ALLERGY": "Food allergy", "HP_FOLLICULITIS": "Folliculitis", "HP_FOLLICULAR_THYROID_CARCINOMA": "Follicular thyroid carcinoma", "HP_FOOT_ACROOSTEOLYSIS": "", "HP_FOOT_OLIGODACTYLY": "Foot oligodactyly", "HP_FRACTURES_OF_THE_LONG_BONES": "", "HP_FOOT_DORSIFLEXOR_WEAKNESS": "Foot dorsiflexor weakness", "HP_FRAGILE_NAILS": "Fragile nails", "HP_FOOT_JOINT_CONTRACTURE": "Foot joint contracture", "HP_FRAGMENTED_ELASTIC_FIBERS_IN_THE_DERMIS": "Fragmented elastic fibers in the dermis", "HP_FRECKLING": "Freckling", "HP_FREQUENT_TEMPER_TANTRUMS": "Frequent temper tantrums", "HP_FRAGMENTED_EPIPHYSES": "Fragmented epiphyses", "HP_FRAGILE_SKIN": "Fragile skin", "HP_FREQUENT_FALLS": "Frequent falls", "HP_FRONTAL_CORTICAL_ATROPHY": "Frontal cortical atrophy", "HP_FRONTAL_HIRSUTISM": "Frontal hirsutism", "HP_FRONTAL_BALDING": "Frontal balding", "HP_FRONTAL_LOBE_DEMENTIA": "Frontal lobe dementia", "HP_FRONTAL_POLYMICROGYRIA": "Frontal polymicrogyria", "HP_FRONTAL_UPSWEEP_OF_HAIR": "Frontal upsweep of hair", "HP_FRONTOTEMPORAL_CEREBRAL_ATROPHY": "Frontotemporal cerebral atrophy", "HP_FRONTOTEMPORAL_DEMENTIA": "Frontotemporal dementia", "HP_FULMINANT_HEPATIC_FAILURE": "Fulminant hepatic failure", "HP_FULL_CHEEKS": "Full cheeks", "HP_FUNCTIONAL_INTESTINAL_OBSTRUCTION": "Functional intestinal obstruction", "HP_FUNDUS_ATROPHY": "", "HP_FUNCTIONAL_ABNORMALITY_OF_MALE_INTERNAL_GENITALIA": "Functional abnormality of male internal genitalia", "HP_FURROWED_TONGUE": "Furrowed tongue", "HP_FUNCTIONAL_ABNORMALITY_OF_THE_GASTROINTESTINAL_TRACT": "Functional abnormality of the gastrointestinal tract", "HP_FUNCTIONAL_MOTOR_DEFICIT": "Functional motor deficit", "HP_FUSED_CERVICAL_VERTEBRAE": "Fused cervical vertebrae", "HP_FUSION_OF_THE_CEREBELLAR_HEMISPHERES": "Fusion of the cerebellar hemispheres", "HP_FUNCTIONAL_ABNORMALITY_OF_THE_MIDDLE_EAR": "Functional abnormality of the middle ear", "HP_FUNCTIONAL_ABNORMALITY_OF_THE_INNER_EAR": "Functional abnormality of the inner ear", "HP_GALACTORRHEA": "Galactorrhea", "HP_GAIT_IMBALANCE": "Gait imbalance", "HP_GAIT_ATAXIA": "Gait ataxia", "HP_GASTRIC_ULCER": "Gastric ulcer", "HP_GALACTOSURIA": "Galactosuria", "HP_GAIT_DISTURBANCE": "Gait disturbance", "HP_GASTRITIS": "Gastritis", "HP_GANGLIONEUROBLASTOMA": "Ganglioneuroblastoma", "HP_GANGRENE": "Gangrene", "HP_GASTROINTESTINAL_EOSINOPHILIA": "Gastrointestinal eosinophilia", "HP_GASTROINTESTINAL_ARTERIOVENOUS_MALFORMATION": "Gastrointestinal arteriovenous malformation", "HP_GASTROINTESTINAL_ATRESIA": "Gastrointestinal atresia", "HP_GASTROINTESTINAL_INFARCTIONS": "Gastrointestinal infarctions", "HP_GASTROESOPHAGEAL_REFLUX": "Gastroesophageal reflux", "HP_GASTROINTESTINAL_STROMA_TUMOR": "Gastrointestinal stroma tumor", "HP_GASTROINTESTINAL_HEMORRHAGE": "Gastrointestinal hemorrhage", "HP_GASTROINTESTINAL_OBSTRUCTION": "Gastrointestinal obstruction", "HP_GASTROINTESTINAL_INFLAMMATION": "Gastrointestinal inflammation", "HP_GASTROINTESTINAL_ULCER": "Gastrointestinal ulcer", "HP_GASTROPARESIS": "Gastroparesis", "HP_GAZE_EVOKED_HORIZONTAL_NYSTAGMUS": "Gaze-evoked horizontal nystagmus", "HP_GASTROSTOMY_TUBE_FEEDING_IN_INFANCY": "Gastrostomy tube feeding in infancy", "HP_GENERALIZED_AMINOACIDURIA": "Generalized aminoaciduria", "HP_GAZE_EVOKED_NYSTAGMUS": "Gaze-evoked nystagmus", "HP_GENERALIZED_AMYLOID_DEPOSITION": "", "HP_GENERALIZED_CEREBRAL_ATROPHY_HYPOPLASIA": "Generalized cerebral atrophy/hypoplasia", "HP_GENERALIZED_AMYOTROPHY": "Generalized amyotrophy", "HP_GENERALIZED_ABNORMALITY_OF_SKIN": "Generalized abnormality of skin", "HP_GENERALIZED_EDEMA": "Generalized edema", "HP_GENERALIZED_CLONIC_SEIZURE": "Generalized clonic seizure", "HP_GENERALIZED_DYSTONIA": "Generalized dystonia", "HP_GENERALIZED_HIRSUTISM": "Generalized hirsutism", "HP_GENERALIZED_HYPERKERATOSIS": "Generalized hyperkeratosis", "HP_GENERALIZED_HYPERREFLEXIA": "Generalized hyperreflexia", "HP_GENERALIZED_HYPERTRICHOSIS": "Generalized hypertrichosis", "HP_GENERALIZED_HYPERPIGMENTATION": "Generalized hyperpigmentation", "HP_GENERALIZED_ICHTHYOSIS": "Generalized ichthyosis", "HP_GENERALIZED_HYPOPIGMENTATION": "Generalized hypopigmentation", "HP_GENERALIZED_HYPOPIGMENTATION_OF_HAIR": "Generalized hypopigmentation of hair", "HP_GENERALIZED_LIMB_MUSCLE_ATROPHY": "Generalized limb muscle atrophy", "HP_GENERALIZED_LIPODYSTROPHY": "Generalized lipodystrophy", "HP_GENERALIZED_JOINT_HYPERMOBILITY": "Generalized joint hypermobility", "HP_GENERALIZED_LYMPHADENOPATHY": "Generalized lymphadenopathy", "HP_GENERALIZED_MYOCLONIC_ATONIC_SEIZURE": "Generalized myoclonic-atonic seizure", "HP_GENERALIZED_NEONATAL_HYPOTONIA": "Generalized neonatal hypotonia", "HP_GENERALIZED_MUSCLE_WEAKNESS": "Generalized muscle weakness", "HP_GENERALIZED_HYPOTONIA": "Generalized hypotonia", "HP_GENERALIZED_MYOCLONIC_SEIZURE": "Generalized myoclonic seizure", "HP_GENERALIZED_NON_CONVULSIVE_STATUS_EPILEPTICUS_WITHOUT_COMA": "", "HP_GENERALIZED_OSTEOPOROSIS": "Generalized osteoporosis", "HP_GENERALIZED_OSTEOSCLEROSIS": "Generalized osteosclerosis", "HP_GENERALIZED_TONIC_SEIZURE": "Generalized tonic seizure", "HP_GENETIC_ANTICIPATION": "Genetic anticipation", "HP_GENERALIZED_ONSET_MOTOR_SEIZURE": "Generalized-onset motor seizure", "HP_GENERALIZED_ONSET_SEIZURE": "Generalized-onset seizure", "HP_GENITAL_NEOPLASM": "Genital neoplasm", "HP_GENU_VARUM": "Genu varum", "HP_GEOGRAPHIC_ATROPHY": "", "HP_GENU_VALGUM": "Genu valgum", "HP_GERMINOMA": "Germinoma", "HP_GERM_CELL_NEOPLASIA": "Germ cell neoplasia", "HP_GIANT_CELL_HEPATITIS": "Giant cell hepatitis", "HP_GIANT_PLATELETS": "Giant platelets", "HP_GIANT_SOMATOSENSORY_EVOKED_POTENTIALS": "Giant somatosensory evoked potentials", "HP_GINGIVAL_FIBROMATOSIS": "Gingival fibromatosis", "HP_GINGIVAL_BLEEDING": "Gingival bleeding", "HP_GINGIVAL_OVERGROWTH": "Gingival overgrowth", "HP_GINGIVAL_RECESSION": "Gingival recession", "HP_GLANDULAR_HYPOSPADIAS": "", "HP_GINGIVITIS": "Gingivitis", "HP_GLIOBLASTOMA_MULTIFORME": "Glioblastoma multiforme", "HP_GLIOMA": "Glioma", "HP_GLIOSIS": "Gliosis", "HP_GLOBOZOOSPERMIA": "Globozoospermia", "HP_GLOBAL_BRAIN_ATROPHY": "Global brain atrophy", "HP_GLAUCOMA": "Glaucoma", "HP_GLOMERULAR_DEPOSITS": "Glomerular deposits", "HP_GLOMERULAR_SUBEPITHELIAL_DEPOSITS": "", "HP_GLOMERULONEPHRITIS": "Glomerulonephritis", "HP_GLOMERULAR_SCLEROSIS": "Glomerular sclerosis", "HP_GLOMERULOPATHY": "Glomerulopathy", "HP_GLOMUS_JUGULAR_TUMOR": "Glomus jugular tumor", "HP_GLOSSITIS": "Glossitis", "HP_GLOSSOPTOSIS": "Glossoptosis", "HP_GLUCAGONOMA": "", "HP_GLUCOCORTOCOID_INSENSITIVE_PRIMARY_HYPERALDOSTERONISM": "Glucocortocoid-insensitive primary hyperaldosteronism", "HP_GLUTARIC_ACIDURIA": "Glutaric aciduria", "HP_GLUCOSE_INTOLERANCE": "Glucose intolerance", "HP_GLYCOSURIA": "Glycosuria", "HP_GOITER": "Goiter", "HP_GONADAL_NEOPLASM": "Gonadal neoplasm", "HP_GONADOTROPIN_DEFICIENCY": "Gonadotropin deficiency", "HP_GONADAL_DYSGENESIS": "Gonadal dysgenesis", "HP_GOUT": "Gout", "HP_GONADOBLASTOMA": "Gonadoblastoma", "HP_GOWERS_SIGN": "Gowers sign", "HP_GRANULAR_MACULAR_APPEARANCE": "Granular macular appearance", "HP_GRANULOMA": "Granuloma", "HP_GRANULOCYTIC_HYPERPLASIA": "Granulocytic hyperplasia", "HP_GRANULOMATOSIS": "Granulomatosis", "HP_GRANULOCYTOPENIA": "", "HP_GUSTATORY_LACRIMATION": "Gustatory lacrimation", "HP_GRAVES_DISEASE": "", "HP_GRAY_MATTER_HETEROTOPIA": "Gray matter heterotopia", "HP_HAIR_PULLING": "Hair-pulling", "HP_HAIR_FOLLICLE_NEOPLASM": "", "HP_GYNECOMASTIA": "Gynecomastia", "HP_HALITOSIS": "Halitosis", "HP_HALLUX_VARUS": "Hallux varus", "HP_HAMARTOMATOUS_POLYPOSIS": "Hamartomatous polyposis", "HP_HALLUCINATIONS": "Hallucinations", "HP_HAMARTOMA": "Hamartoma", "HP_HAMARTOMA_OF_THE_ORBITAL_REGION": "Hamartoma of the orbital region", "HP_HAMARTOMA_OF_TONGUE": "Hamartoma of tongue", "HP_HAMSTRING_CONTRACTURES": "Hamstring contractures", "HP_HAND_APRAXIA": "Hand apraxia", "HP_HAMMERTOE": "Hammertoe", "HP_HANDGRIP_MYOTONIA": "Handgrip myotonia", "HP_HAND_CLENCHING": "Hand clenching", "HP_HAND_MUSCLE_ATROPHY": "Hand muscle atrophy", "HP_HAND_MUSCLE_WEAKNESS": "Hand muscle weakness", "HP_HAPPY_DEMEANOR": "Happy demeanor", "HP_HAND_TREMOR": "Hand tremor", "HP_HASHIMOTO_THYROIDITIS": "Hashimoto thyroiditis", "HP_HAND_POLYDACTYLY": "Hand polydactyly", "HP_HBS_HEMOGLOBIN": "HbS hemoglobin", "HP_HEAD_BANGING": "Head-banging", "HP_HEAD_TITUBATION": "Head titubation", "HP_HEAD_TREMOR": "Head tremor", "HP_HEADACHE": "Headache", "HP_HEART_BLOCK": "Heart block", "HP_HELICOBACTER_PYLORI_INFECTION": "Helicobacter pylori infection", "HP_HEMANGIOMATOSIS": "Hemangiomatosis", "HP_HEAT_INTOLERANCE": "Heat intolerance", "HP_HEMANGIOBLASTOMA": "Hemangioblastoma", "HP_HEINZ_BODIES": "Heinz bodies", "HP_HEMATOCHEZIA": "Hematochezia", "HP_HEMATEMESIS": "Hematemesis", "HP_HEMERALOPIA": "Hemeralopia", "HP_HEMATURIA": "", "HP_HEMATOLOGICAL_NEOPLASM": "Hematological neoplasm", "HP_HEMIATROPHY": "Hemiatrophy", "HP_HEMIANOPIA": "Hemianopia", "HP_HEMIFACIAL_SPASM": "Hemifacial spasm", "HP_HEMIMEGALENCEPHALY": "Hemimegalencephaly", "HP_HEMIHYPERTROPHY": "Hemihypertrophy", "HP_HEMIPARESIS": "Hemiparesis", "HP_HEMIPLEGIA": "Hemiplegia", "HP_HEMOLYTIC_UREMIC_SYNDROME": "Hemolytic-uremic syndrome", "HP_HEMIVERTEBRAE": "Hemivertebrae", "HP_HEMOGLOBINURIA": "Hemoglobinuria", "HP_HEMOPHAGOCYTOSIS": "Hemophagocytosis", "HP_HEMIPLEGIA_HEMIPARESIS": "Hemiplegia/hemiparesis", "HP_HEMOTHORAX": "Hemothorax", "HP_HEMOPTYSIS": "Hemoptysis", "HP_HEMORRHAGE_OF_THE_EYE": "Hemorrhage of the eye", "HP_HEPARAN_SULFATE_EXCRETION_IN_URINE": "Heparan sulfate excretion in urine", "HP_HEPATIC_BRIDGING_FIBROSIS": "Hepatic bridging fibrosis", "HP_HEPATIC_CYSTS": "Hepatic cysts", "HP_HEPATIC_ENCEPHALOPATHY": "Hepatic encephalopathy", "HP_HEPATIC_CALCIFICATION": "Hepatic calcification", "HP_HEPATIC_NECROSIS": "Hepatic necrosis", "HP_HEPATIC_FAILURE": "Hepatic failure", "HP_HEPATIC_VEIN_THROMBOSIS": "Hepatic vein thrombosis", "HP_HEPATOCELLULAR_ADENOMA": "Hepatocellular adenoma", "HP_HEPATITIS": "Hepatitis", "HP_HEPATIC_FIBROSIS": "Hepatic fibrosis", "HP_HEPATOBLASTOMA": "Hepatoblastoma", "HP_HEPATOCELLULAR_CARCINOMA": "Hepatocellular carcinoma", "HP_HEPATOSPLENOMEGALY": "Hepatosplenomegaly", "HP_HERPES_SIMPLEX_ENCEPHALITIS": "Herpes simplex encephalitis", "HP_HEREDITARY_NONPOLYPOSIS_COLORECTAL_CARCINOMA": "Hereditary nonpolyposis colorectal carcinoma", "HP_HETEROTAXY": "Heterotaxy", "HP_HEPATOMEGALY": "Hepatomegaly", "HP_HETEROPHORIA": "Heterophoria", "HP_HETEROCHROMIA_IRIDIS": "", "HP_HERNIA": "Hernia", "HP_HIATUS_HERNIA": "Hiatus hernia", "HP_HIGHLY_ELEVATED_CREATINE_KINASE": "Highly elevated creatine kinase", "HP_HIGH_ANTERIOR_HAIRLINE": "High anterior hairline", "HP_HETEROTROPIA": "Heterotropia", "HP_HIGH_FREQUENCY_HEARING_IMPAIRMENT": "High-frequency hearing impairment", "HP_HIGHLY_ARCHED_EYEBROW": "Highly arched eyebrow", "HP_HIGH_FREQUENCY_SENSORINEURAL_HEARING_IMPAIRMENT": "High-frequency sensorineural hearing impairment", "HP_HIGH_HYPERMETROPIA": "High hypermetropia", "HP_HIGH_FOREHEAD": "High forehead", "HP_HIGH_OUTPUT_CONGESTIVE_HEART_FAILURE": "High-output congestive heart failure", "HP_HIGH_MYOPIA": "High myopia", "HP_HIGH_PITCHED_CRY": "High-pitched cry", "HP_HIGH_SERUM_CALCITRIOL": "High serum calcitriol", "HP_HIGH_PITCHED_VOICE": "", "HP_HIGH_NARROW_PALATE": "High, narrow palate", "HP_HIPPOCAMPAL_ATROPHY": "Hippocampal atrophy", "HP_HIP_CONTRACTURE": "Hip contracture", "HP_HIGH_PALATE": "High palate", "HP_HIP_FLEXOR_WEAKNESS": "Hip flexor weakness", "HP_HIP_DISLOCATION": "Hip dislocation", "HP_HIP_SUBLUXATION": "Hip subluxation", "HP_HIP_DYSPLASIA": "Hip dysplasia", "HP_HIP_OSTEOARTHRITIS": "Hip osteoarthritis", "HP_HIP_PAIN": "Hip pain", "HP_HISTIOCYTOSIS": "Histiocytosis", "HP_HIRSUTISM": "Hirsutism", "HP_HOARSE_CRY": "Hoarse cry", "HP_HITCHHIKER_THUMB": "Hitchhiker thumb", "HP_HOARSE_VOICE": "Hoarse voice", "HP_HOMOCYSTINURIA": "Homocystinuria", "HP_HODGKIN_LYMPHOMA": "Hodgkin lymphoma", "HP_HOODED_EYELID": "Hooded eyelid", "HP_HORIZONTAL_EYEBROW": "Horizontal eyebrow", "HP_HOLOPROSENCEPHALY": "Holoprosencephaly", "HP_HOFFMANN_SIGN": "Hoffmann sign", "HP_HORIZONTAL_NYSTAGMUS": "Horizontal nystagmus", "HP_HORIZONTAL_RIBS": "Horizontal ribs", "HP_HORIZONTAL_PENDULAR_NYSTAGMUS": "Horizontal pendular nystagmus", "HP_HORNER_SYNDROME": "Horner syndrome", "HP_HYDRANENCEPHALY": "Hydranencephaly", "HP_HYDROCELE_TESTIS": "Hydrocele testis", "HP_HORSESHOE_KIDNEY": "Horseshoe kidney", "HP_HYDROMETROCOLPOS": "Hydrometrocolpos", "HP_HYDROURETER": "Hydroureter", "HP_HYDROXYPROLINURIA": "Hydroxyprolinuria", "HP_HYDROXYPROLINEMIA": "Hydroxyprolinemia", "HP_HYPERACTIVE_DEEP_TENDON_REFLEXES": "Hyperactive deep tendon reflexes", "HP_HYDROPS_FETALIS": "Hydrops fetalis", "HP_HYDROCEPHALUS": "Hydrocephalus", "HP_HYPERACTIVE_PATELLAR_REFLEX": "", "HP_HYPERACTIVE_RENIN_ANGIOTENSIN_SYSTEM": "Hyperactive renin-angiotensin system", "HP_HYPERACUSIS": "Hyperacusis", "HP_HYPERALDOSTERONISM": "", "HP_HYPERAUTOFLUORESCENT_MACULAR_LESION": "Hyperautofluorescent macular lesion", "HP_HYPERAMMONEMIA": "Hyperammonemia", "HP_HYPERAUTOFLUORESCENT_RETINAL_LESION": "Hyperautofluorescent retinal lesion", "HP_HYPERCAPNIA": "", "HP_HYPERCALCEMIA": "Hypercalcemia", "HP_HYPERCHLOREMIC_ACIDOSIS": "Hyperchloremic acidosis", "HP_HYPERCONVEX_FINGERNAILS": "Hyperconvex fingernails", "HP_HYPERCOAGULABILITY": "Hypercoagulability", "HP_HYPERCHOLESTEROLEMIA": "Hypercholesterolemia", "HP_HYPERCONVEX_NAIL": "Hyperconvex nail", "HP_HYPERECHOGENIC_PANCREAS": "Hyperechogenic pancreas", "HP_HYPERESTHESIA": "Hyperesthesia", "HP_HYPEREOSINOPHILIA": "", "HP_HYPEREXTENSIBILITY_AT_ELBOW": "Hyperextensibility at elbow", "HP_HYPERGALACTOSEMIA": "Hypergalactosemia", "HP_HYPEREXTENSIBILITY_OF_THE_FINGER_JOINTS": "Hyperextensibility of the finger joints", "HP_HYPEREXTENSIBILITY_OF_THE_KNEE": "Hyperextensibility of the knee", "HP_HYPERGLUTAMINEMIA": "Hyperglutaminemia", "HP_HYPERGASTRINEMIA": "", "HP_HYPEREXTENSIBLE_SKIN": "Hyperextensible skin", "HP_HYPERGLYCINURIA": "Hyperglycinuria", "HP_HYPERGRANULOSIS": "Hypergranulosis", "HP_HYPERGLYCEMIA": "Hyperglycemia", "HP_HYPERGONADOTROPIC_HYPOGONADISM": "Hypergonadotropic hypogonadism", "HP_HYPERINSULINEMIC_HYPOGLYCEMIA": "Hyperinsulinemic hypoglycemia", "HP_HYPERINTENSITY_OF_CEREBRAL_WHITE_MATTER_ON_MRI": "Hyperintensity of cerebral white matter on MRI", "HP_HYPERHIDROSIS": "Hyperhidrosis", "HP_HYPERKALEMIA": "Hyperkalemia", "HP_HYPERKERATOTIC_PAPULE": "Hyperkeratotic papule", "HP_HYPERKETONEMIA": "Hyperketonemia", "HP_HYPERKERATOSIS": "Hyperkeratosis", "HP_HYPERKINETIC_MOVEMENTS": "Hyperkinetic movements", "HP_HYPERLIPOPROTEINEMIA": "Hyperlipoproteinemia", "HP_HYPERLIPIDEMIA": "Hyperlipidemia", "HP_HYPERMAGNESEMIA": "Hypermagnesemia", "HP_HYPERLYSINURIA": "Hyperlysinuria", "HP_HYPERLORDOSIS": "Hyperlordosis", "HP_HYPERMETRIC_SACCADES": "Hypermetric saccades", "HP_HYPERMETHIONINEMIA": "Hypermethioninemia", "HP_HYPERMOBILITY_OF_INTERPHALANGEAL_JOINTS": "Hypermobility of interphalangeal joints", "HP_HYPERNASAL_SPEECH": "Hypernasal speech", "HP_HYPERMETROPIA": "Hypermetropia", "HP_HYPERNATRIURIA": "Hypernatriuria", "HP_HYPERNATREMIA": "Hypernatremia", "HP_HYPEROPIC_ASTIGMATISM": "Hyperopic astigmatism", "HP_HYPEROXALURIA": "Hyperoxaluria", "HP_HYPERPARATHYROIDISM": "Hyperparathyroidism", "HP_HYPERORALITY": "Hyperorality", "HP_HYPERPHENYLALANINEMIA": "Hyperphenylalaninemia", "HP_HYPEROSTOSIS": "Hyperostosis", "HP_HYPERPIGMENTATION_OF_THE_FUNDUS": "", "HP_HYPERPHOSPHATEMIA": "Hyperphosphatemia", "HP_HYPERPIGMENTATION_IN_SUN_EXPOSED_AREAS": "Hyperpigmentation in sun-exposed areas", "HP_HYPERPIGMENTED_HYPOPIGMENTED_MACULES": "Hyperpigmented/hypopigmented macules", "HP_HYPERPIGMENTED_PAPULE": "Hyperpigmented papule", "HP_HYPERPITUITARISM": "Hyperpituitarism", "HP_HYPERPLASIA_OF_THE_MAXILLA": "Hyperplasia of the maxilla", "HP_HYPERPLASIA_OF_MIDFACE": "Hyperplasia of midface", "HP_HYPERPIGMENTATION_OF_THE_SKIN": "Hyperpigmentation of the skin", "HP_HYPERPLASTIC_CALLUS_FORMATION": "Hyperplastic callus formation", "HP_HYPERPROSTAGLANDINURIA": "Hyperprostaglandinuria", "HP_HYPERREFLEXIA_IN_UPPER_LIMBS": "", "HP_HYPERSEGMENTATION_OF_NEUTROPHIL_NUCLEI": "Hypersegmentation of neutrophil nuclei", "HP_HYPERSOMNIA": "", "HP_HYPERSPLENISM": "", "HP_HYPERTENSIVE_CRISIS": "Hypertensive crisis", "HP_HYPERTHYROIDISM": "Hyperthyroidism", "HP_HYPERREFLEXIA": "Hyperreflexia", "HP_HYPERTONIC_DEHYDRATION": "Hypertonic dehydration", "HP_HYPERTENSION": "Hypertension", "HP_HYPERTELORISM": "Hypertelorism", "HP_HYPERTRIGLYCERIDEMIA": "Hypertriglyceridemia", "HP_HYPERTRICHOSIS": "Hypertrichosis", "HP_HYPERTROPHIC_NERVE_CHANGES": "Hypertrophic nerve changes", "HP_HYPERTYROSINEMIA": "", "HP_HYPERTONIA": "Hypertonia", "HP_HYPERURICOSURIA": "Hyperuricosuria", "HP_HYPERTROPHIC_CARDIOMYOPATHY": "Hypertrophic cardiomyopathy", "HP_HYPERURICEMIA": "Hyperuricemia", "HP_HYPERVENTILATION": "Hyperventilation", "HP_HYPNOPOMPIC_HALLUCINATION": "", "HP_HYPOAMYLASEMIA": "", "HP_HYPOARGININEMIA": "Hypoargininemia", "HP_HYPOAUTOFLUORESCENT_RETINAL_LESION": "Hypoautofluorescent retinal lesion", "HP_HYPOCALCEMIC_TETANY": "Hypocalcemic tetany", "HP_HYPOCALCEMIA": "Hypocalcemia", "HP_HYPOCALCEMIC_SEIZURES": "Hypocalcemic seizures", "HP_HYPOCALCIURIA": "Hypocalciuria", "HP_HYPOCHROMIA": "Hypochromia", "HP_HYPOCHLOREMIA": "Hypochloremia", "HP_HYPOCHOLESTEROLEMIA": "Hypocholesterolemia", "HP_HYPOCHROMIC_MICROCYTIC_ANEMIA": "Hypochromic microcytic anemia", "HP_HYPOCHROMIC_ANEMIA": "Hypochromic anemia", "HP_HYPODONTIA": "Hypodontia", "HP_HYPOGLYCEMIC_COMA": "Hypoglycemic coma", "HP_HYPOGLYCEMIC_SEIZURES": "Hypoglycemic seizures", "HP_HYPOESTHESIA": "Hypoesthesia", "HP_HYPOGLYCEMIA": "Hypoglycemia", "HP_HYPOHIDROSIS": "Hypohidrosis", "HP_HYPOINSULINEMIA": "Hypoinsulinemia", "HP_HYPOHIDROSIS_OR_HYPERHIDROSIS": "", "HP_HYPOGONADOTROPIC_HYPOGONADISM": "Hypogonadotropic hypogonadism", "HP_HYPOGONADISM": "Hypogonadism", "HP_HYPOINTENSITY_OF_CEREBRAL_WHITE_MATTER_ON_MRI": "Hypointensity of cerebral white matter on MRI", "HP_HYPOKALEMIA": "Hypokalemia", "HP_HYPOKALEMIC_METABOLIC_ALKALOSIS": "Hypokalemic metabolic alkalosis", "HP_HYPOKALEMIC_ALKALOSIS": "Hypokalemic alkalosis", "HP_HYPOKETOTIC_HYPOGLYCEMIA": "Hypoketotic hypoglycemia", "HP_HYPOLIPIDEMIA": "Hypolipidemia", "HP_HYPOMELANOTIC_MACULE": "Hypomelanotic macule", "HP_HYPOKINESIA": "Hypokinesia", "HP_HYPOMETHIONINEMIA": "Hypomethioninemia", "HP_HYPOLIPOPROTEINEMIA": "Hypolipoproteinemia", "HP_HYPOMETRIC_SACCADES": "Hypometric saccades", "HP_HYPOMIMIC_FACE": "Hypomimic face", "HP_HYPOPHOSPHATEMIA": "Hypophosphatemia", "HP_HYPOPARATHYROIDISM": "Hypoparathyroidism", "HP_HYPOPHOSPHATEMIC_RICKETS": "Hypophosphatemic rickets", "HP_HYPOPIGMENTATION_OF_THE_FUNDUS": "", "HP_HYPOPIGMENTATION_OF_HAIR": "Hypopigmentation of hair", "HP_HYPOPIGMENTED_MACULE": "Hypopigmented macule", "HP_HYPOPLASIA_OF_OLFACTORY_TRACT": "Hypoplasia of olfactory tract", "HP_HYPOPIGMENTATION_OF_THE_SKIN": "Hypopigmentation of the skin", "HP_HYPOPIGMENTED_SKIN_PATCHES": "Hypopigmented skin patches", "HP_HYPOPITUITARISM": "Hypopituitarism", "HP_HYPOPLASIA_OF_THE_BLADDER": "Hypoplasia of the bladder", "HP_HYPOPLASIA_OF_THE_COCHLEA": "Hypoplasia of the cochlea", "HP_HYPOPLASIA_OF_TEETH": "Hypoplasia of teeth", "HP_HYPOPLASIA_OF_THE_EAR_CARTILAGE": "Hypoplasia of the ear cartilage", "HP_HYPOPLASIA_OF_PENIS": "Hypoplasia of penis", "HP_HYPOPLASIA_OF_THE_EPIGLOTTIS": "Hypoplasia of the epiglottis", "HP_HYPOPLASIA_OF_THE_FEMORAL_HEAD": "Hypoplasia of the femoral head", "HP_HYPOPLASIA_OF_THE_FOVEA": "", "HP_HYPOPLASIA_OF_THE_MUSCULATURE": "Hypoplasia of the musculature", "HP_HYPOPLASIA_OF_THE_FRONTAL_LOBES": "Hypoplasia of the frontal lobes", "HP_HYPOPLASIA_OF_THE_CORPUS_CALLOSUM": "Hypoplasia of the corpus callosum", "HP_HYPOPLASIA_OF_THE_ODONTOID_PROCESS": "Hypoplasia of the odontoid process", "HP_HYPOPLASIA_OF_THE_IRIS": "Hypoplasia of the iris", "HP_HYPOPLASIA_OF_THE_OLFACTORY_BULB": "Hypoplasia of the olfactory bulb", "HP_HYPOPLASIA_OF_THE_PRIMARY_TEETH": "Hypoplasia of the primary teeth", "HP_HYPOPLASIA_OF_THE_PHALANGES_OF_THE_TOES": "Hypoplasia of the phalanges of the toes", "HP_HYPOPLASIA_OF_THE_PONS": "Hypoplasia of the pons", "HP_HYPOPLASIA_OF_THE_VAGINA": "Hypoplasia of the vagina", "HP_HYPOPLASIA_OF_THE_VENTRAL_PONS": "Hypoplasia of the ventral pons", "HP_HYPOPLASIA_OF_THE_UTERUS": "Hypoplasia of the uterus", "HP_HYPOPLASIA_OF_THE_RADIUS": "Hypoplasia of the radius", "HP_HYPOPLASTIC_ANEMIA": "Hypoplastic anemia", "HP_HYPOPLASIA_OF_THE_ZYGOMATIC_BONE": "Hypoplasia of the zygomatic bone", "HP_HYPOPLASTIC_ACETABULAE": "Hypoplastic acetabulae", "HP_HYPOPLASTIC_CERVICAL_VERTEBRAE": "", "HP_HYPOPLASTIC_AORTIC_ARCH": "Hypoplastic aortic arch", "HP_HYPOPLASTIC_DERMOEPIDERMAL_HEMIDESMOSOMES": "Hypoplastic dermoepidermal hemidesmosomes", "HP_HYPOPLASTIC_FIFTH_FINGERNAIL": "Hypoplastic fifth fingernail", "HP_HYPOPLASTIC_FEMALE_EXTERNAL_GENITALIA": "Hypoplastic female external genitalia", "HP_HYPOPLASTIC_FIFTH_TOENAIL": "Hypoplastic fifth toenail", "HP_HYPOPLASTIC_FRONTAL_SINUSES": "Hypoplastic frontal sinuses", "HP_HYPOPLASTIC_HELICES": "Hypoplastic helices", "HP_HYPOPLASTIC_FINGERNAIL": "Hypoplastic fingernail", "HP_HYPOPLASTIC_HEART": "", "HP_HYPOPLASTIC_HIPPOCAMPUS": "Hypoplastic hippocampus", "HP_HYPOPLASTIC_ILIAC_WING": "Hypoplastic iliac wing", "HP_HYPOPLASTIC_ILIA": "Hypoplastic ilia", "HP_HYPOPLASTIC_IRIS_STROMA": "Hypoplastic iris stroma", "HP_HYPOPLASTIC_ISCHIA": "Hypoplastic ischia", "HP_HYPOPLASTIC_LABIA_MAJORA": "Hypoplastic labia majora", "HP_HYPOPLASTIC_LABIA_MINORA": "", "HP_HYPOPLASTIC_NASAL_BRIDGE": "Hypoplastic nasal bridge", "HP_HYPOPLASTIC_PELVIS": "Hypoplastic pelvis", "HP_HYPOPLASTIC_PUBIC_RAMUS": "Hypoplastic pubic ramus", "HP_HYPOPLASTIC_NIPPLES": "Hypoplastic nipples", "HP_HYPOPLASTIC_SACRUM": "Hypoplastic sacrum", "HP_HYPOPLASTIC_SPLEEN": "Hypoplastic spleen", "HP_HYPOPROTEINEMIA": "Hypoproteinemia", "HP_HYPOPLASTIC_VERTEBRAL_BODIES": "Hypoplastic vertebral bodies", "HP_HYPOPLASTIC_TOENAILS": "Hypoplastic toenails", "HP_HYPOREFLEXIA_OF_LOWER_LIMBS": "Hyporeflexia of lower limbs", "HP_HYPOREFLEXIA_OF_UPPER_LIMBS": "Hyporeflexia of upper limbs", "HP_HYPOSEGMENTATION_OF_NEUTROPHIL_NUCLEI": "Hyposegmentation of neutrophil nuclei", "HP_HYPOREFLEXIA": "Hyporeflexia", "HP_HYPOSMIA": "Hyposmia", "HP_HYPOTHALAMIC_GONADOTROPIN_RELEASING_HORMONE_DEFICIENCY": "", "HP_HYPOTHALAMIC_HYPOTHYROIDISM": "Hypothalamic hypothyroidism", "HP_HYPOTHALAMIC_HAMARTOMA": "Hypothalamic hamartoma", "HP_HYPOTENSION": "Hypotension", "HP_HYPOTELORISM": "Hypotelorism", "HP_HYPOURICEMIA": "Hypouricemia", "HP_HYPOTHERMIA": "Hypothermia", "HP_HYPOVENTILATION": "Hypoventilation", "HP_HYPOVOLEMIC_SHOCK": "Hypovolemic shock", "HP_HYPOVOLEMIA": "Hypovolemia", "HP_ILEAL_ATRESIA": "Ileal atresia", "HP_ILEUS": "Ileus", "HP_IMMOTILE_CILIA": "Immotile cilia", "HP_IMMOTILE_SPERM": "Immotile sperm", "HP_HYPSARRHYTHMIA": "Hypsarrhythmia", "HP_IMMUNE_DYSREGULATION": "Immune dysregulation", "HP_ICHTHYOSIS": "Ichthyosis", "HP_IMPACTED_TOOTH": "Impacted tooth", "HP_IMPAIRED_ADP_INDUCED_PLATELET_AGGREGATION": "Impaired ADP-induced platelet aggregation", "HP_IMMUNODEFICIENCY": "Immunodeficiency", "HP_IMPAIRED_ARACHIDONIC_ACID_INDUCED_PLATELET_AGGREGATION": "Impaired arachidonic acid-induced platelet aggregation", "HP_IMMUNOLOGIC_HYPERSENSITIVITY": "Immunologic hypersensitivity", "HP_IMPAIRED_COLLAGEN_INDUCED_PLATELET_AGGREGATION": "Impaired collagen-induced platelet aggregation", "HP_IMPAIRED_CORTISOL_RESPONSE_TO_INSULIN_STIMULATION_TEST": "Impaired cortisol response to insulin stimulation test", "HP_IMPAIRED_ANTIGEN_SPECIFIC_RESPONSE": "Impaired antigen-specific response", "HP_IMPAIRED_DISTAL_PROPRIOCEPTION": "Impaired distal proprioception", "HP_IMPAIRED_DISTAL_TACTILE_SENSATION": "Impaired distal tactile sensation", "HP_IMPAIRED_DISTAL_VIBRATION_SENSATION": "Impaired distal vibration sensation", "HP_IMPAIRED_EXECUTIVE_FUNCTIONING": "Impaired executive functioning", "HP_IMPAIRED_EPINEPHRINE_INDUCED_PLATELET_AGGREGATION": "Impaired epinephrine-induced platelet aggregation", "HP_IMPAIRED_HORIZONTAL_SMOOTH_PURSUIT": "Impaired horizontal smooth pursuit", "HP_IMPAIRED_MYOCARDIAL_CONTRACTILITY": "Impaired myocardial contractility", "HP_IMPAIRED_LYMPHOCYTE_TRANSFORMATION_WITH_PHYTOHEMAGGLUTININ": "Impaired lymphocyte transformation with phytohemagglutinin", "HP_IMPAIRED_NEUTROPHIL_BACTERICIDAL_ACTIVITY": "", "HP_IMPAIRED_GLUCOSE_TOLERANCE": "Impaired glucose tolerance", "HP_IMPAIRED_NEUTROPHIL_CHEMOTAXIS": "", "HP_IMPAIRED_MASTICATION": "Impaired mastication", "HP_IMPAIRED_OCULAR_ABDUCTION": "Impaired ocular abduction", "HP_IMPAIRED_OCULAR_ADDUCTION": "Impaired ocular adduction", "HP_IMPAIRED_OROPHARYNGEAL_SWALLOW_RESPONSE": "Impaired oropharyngeal swallow response", "HP_IMPAIRED_OXIDATIVE_BURST": "", "HP_IMPAIRED_RENAL_CONCENTRATING_ABILITY": "Impaired renal concentrating ability", "HP_IMPAIRED_PAIN_SENSATION": "Impaired pain sensation", "HP_IMPAIRED_RISTOCETIN_INDUCED_PLATELET_AGGREGATION": "Impaired ristocetin-induced platelet aggregation", "HP_IMPAIRED_PROPRIOCEPTION": "Impaired proprioception", "HP_IMPAIRED_TANDEM_GAIT": "Impaired tandem gait", "HP_IMPAIRED_TACTILE_SENSATION": "Impaired tactile sensation", "HP_IMPAIRED_SMOOTH_PURSUIT": "Impaired smooth pursuit", "HP_IMPAIRED_VIBRATION_SENSATION_AT_ANKLES": "Impaired vibration sensation at ankles", "HP_IMPAIRED_T_CELL_FUNCTION": "", "HP_IMPAIRED_TEMPERATURE_SENSATION": "Impaired temperature sensation", "HP_IMPAIRED_VIBRATION_SENSATION_IN_THE_LOWER_LIMBS": "Impaired vibration sensation in the lower limbs", "HP_IMPAIRED_VIBRATORY_SENSATION": "Impaired vibratory sensation", "HP_IMPAIRED_VISUOSPATIAL_CONSTRUCTIVE_COGNITION": "Impaired visuospatial constructive cognition", "HP_IMPAIRMENT_IN_PERSONALITY_FUNCTIONING": "Impairment in personality functioning", "HP_IMPOTENCE": "Impotence", "HP_IMPAIRMENT_OF_ACTIVITIES_OF_DAILY_LIVING": "Impairment of activities of daily living", "HP_INAPPROPRIATE_BEHAVIOR": "Inappropriate behavior", "HP_INAPPROPRIATE_ANTIDIURETIC_HORMONE_SECRETION": "Inappropriate antidiuretic hormone secretion", "HP_IMPULSIVITY": "Impulsivity", "HP_INAPPROPRIATE_CRYING": "Inappropriate crying", "HP_INABILITY_TO_WALK": "Inability to walk", "HP_INCISOR_MACRODONTIA": "Incisor macrodontia", "HP_INAPPROPRIATE_LAUGHTER": "Inappropriate laughter", "HP_INCOMPLETE_PARTITION_OF_THE_COCHLEA_TYPE_II": "", "HP_INCOMPREHENSIBLE_SPEECH": "Incomprehensible speech", "HP_INCREASED_ARM_SPAN": "Increased arm span", "HP_INCREASED_ADIPOSE_TISSUE": "Increased adipose tissue", "HP_INCOORDINATION": "Incoordination", "HP_INCREASED_ASPARTATE_FAMILY_AMINO_ACID_LEVEL_IN_URINE": "Increased aspartate family amino acid level in urine", "HP_INCREASED_BODY_MASS_INDEX": "Increased body mass index", "HP_INCREASED_CEREBRAL_LIPOFUSCIN": "Increased cerebral lipofuscin", "HP_INCREASED_BONE_MINERAL_DENSITY": "Increased bone mineral density", "HP_INCREASED_CIRCULATING_ACTH_LEVEL": "Increased circulating ACTH level", "HP_INCREASED_B_CELL_COUNT": "", "HP_INCREASED_CIRCULATING_ANDROGEN_CONCENTRATION": "Increased circulating androgen concentration", "HP_INCREASED_CIRCULATING_ANTIBODY_LEVEL": "", "HP_INCREASED_CIRCULATING_CORTISOL_LEVEL": "", "HP_INCREASED_BODY_WEIGHT": "Increased body weight", "HP_INCREASED_CIRCULATING_FREE_FATTY_ACID_LEVEL": "Increased circulating free fatty acid level", "HP_INCREASED_CIRCULATING_CREATINE_KINASE_MB_ISOFORM": "", "HP_INCREASED_CIRCULATING_HEMOGLOBIN_CONCENTRATION": "Increased circulating hemoglobin concentration", "HP_INCREASED_CIRCULATING_GONADOTROPIN_LEVEL": "Increased circulating gonadotropin level", "HP_INCREASED_CIRCULATING_IGG_LEVEL": "", "HP_INCREASED_CIRCULATING_IGM_LEVEL": "Increased circulating IgM level", "HP_INCREASED_CIRCULATING_IGE_LEVEL": "", "HP_INCREASED_CIRCULATING_IGA_LEVEL": "", "HP_INCREASED_CIRCULATING_INTERFERON_GAMMA_CONCENTRATION": "", "HP_INCREASED_CIRCULATING_INSULIN_LIKE_GROWTH_FACTOR_1_CONCENTRATION": "Increased circulating insulin-like growth factor 1 concentration", "HP_INCREASED_CIRCULATING_INTERLEUKIN_6_CONCENTRATION": "Increased circulating interleukin 6 concentration", "HP_INCREASED_CIRCULATING_INTERLEUKIN_18_CONCENTRATION": "", "HP_INCREASED_CIRCULATING_IRON_CONCENTRATION": "Increased circulating iron concentration", "HP_INCREASED_CIRCULATING_PROLACTIN_CONCENTRATION": "Increased circulating prolactin concentration", "HP_INCREASED_CIRCULATING_THYROGLOBULIN_CONCENTRATION": "Increased circulating thyroglobulin concentration", "HP_INCREASED_CIRCULATING_LACTATE_CONCENTRATION": "Increased circulating lactate concentration", "HP_INCREASED_CIRCULATING_LACTATE_DEHYDROGENASE_CONCENTRATION": "Increased circulating lactate dehydrogenase concentration", "HP_INCREASED_CIRCULATING_RENIN_LEVEL": "", "HP_INCREASED_CONNECTIVE_TISSUE": "Increased connective tissue", "HP_INCREASED_CIRCULATING_VERY_LONG_CHAIN_FATTY_ACID_CONCENTRATION": "Increased circulating very long-chain fatty acid concentration", "HP_INCREASED_CORNEAL_THICKNESS": "Increased corneal thickness", "HP_INCREASED_C_PEPTIDE_LEVEL": "Increased C-peptide level", "HP_INCREASED_CUP_TO_DISC_RATIO": "Increased cup-to-disc ratio", "HP_INCREASED_DENSITY_OF_LONG_BONES": "Increased density of long bones", "HP_INCREASED_ERYTHROCYTE_PROTOPORPHYRIN_CONCENTRATION": "", "HP_INCREASED_ENDOMYSIAL_CONNECTIVE_TISSUE": "Increased endomysial connective tissue", "HP_INCREASED_FEMALE_LIBIDO": "Increased female libido", "HP_INCREASED_FECAL_PORPHYRIN": "Increased fecal porphyrin", "HP_INCREASED_GLUTAMINE_FAMILY_AMINO_ACID_LEVEL_IN_URINE": "Increased glutamine family amino acid level in urine", "HP_INCREASED_FEMORAL_ANTEVERSION": "Increased femoral anteversion", "HP_INCREASED_HEMATOCRIT": "Increased hematocrit", "HP_INCREASED_HEPATIC_ECHOGENICITY": "Increased hepatic echogenicity", "HP_INCREASED_HEPATIC_GLYCOGEN_CONTENT": "", "HP_INCREASED_HEPATOCELLULAR_LIPID_DROPLETS": "", "HP_INCREASED_INTERVERTEBRAL_SPACE": "Increased intervertebral space", "HP_INCREASED_INTRAMYOCELLULAR_LIPID_DROPLETS": "Increased intramyocellular lipid droplets", "HP_INCREASED_LAXITY_OF_ANKLES": "", "HP_INCREASED_LAXITY_OF_FINGERS": "Increased laxity of fingers", "HP_INCREASED_JITTER_AT_SINGLE_FIBER_EMG": "Increased jitter at single fiber EMG", "HP_INCREASED_LEFT_VENTRICULAR_END_DIASTOLIC_VOLUME": "Increased left ventricular end-diastolic volume", "HP_INCREASED_LEVEL_OF_HIPPURIC_ACID_IN_URINE": "Increased level of hippuric acid in urine", "HP_INCREASED_LEVEL_OF_L_FUCOSE_IN_URINE": "Increased level of L-fucose in urine", "HP_INCREASED_LDL_CHOLESTEROL_CONCENTRATION": "Increased LDL cholesterol concentration", "HP_INCREASED_MEAN_CORPUSCULAR_HEMOGLOBIN_CONCENTRATION": "Increased mean corpuscular hemoglobin concentration", "HP_INCREASED_INFLAMMATORY_RESPONSE": "Increased inflammatory response", "HP_INCREASED_MEAN_PLATELET_VOLUME": "Increased mean platelet volume", "HP_INCREASED_MUSCLE_FATIGUABILITY": "Increased muscle fatiguability", "HP_INCREASED_MUSCLE_GLYCOGEN_CONTENT": "", "HP_INCREASED_MEGAKARYOCYTE_COUNT": "Increased megakaryocyte count", "HP_INCREASED_NEURONAL_AUTOFLUORESCENT_LIPOPIGMENT": "Increased neuronal autofluorescent lipopigment", "HP_INCREASED_OVERBITE": "Increased overbite", "HP_INCREASED_NUCHAL_TRANSLUCENCY": "Increased nuchal translucency", "HP_INCREASED_MUSCLE_LIPID_CONTENT": "Increased muscle lipid content", "HP_INCREASED_PROPORTION_OF_CD25_MAST_CELLS": "Increased proportion of CD25+ mast cells", "HP_INCREASED_NUMBER_OF_SKIN_FOLDS": "Increased number of skin folds", "HP_INCREASED_PROTEINOGENIC_AMINO_ACID_LEVEL_IN_URINE": "Increased proteinogenic amino acid level in urine", "HP_INCREASED_RED_BLOOD_CELL_MASS": "Increased red blood cell mass", "HP_INCREASED_PULMONARY_VASCULAR_RESISTANCE": "Increased pulmonary vascular resistance", "HP_INCREASED_SENSITIVITY_TO_IONIZING_RADIATION": "Increased sensitivity to ionizing radiation", "HP_INCREASED_SERUM_ESTRADIOL": "Increased serum estradiol", "HP_INCREASED_SERUM_SEROTONIN": "Increased serum serotonin", "HP_INCREASED_SERUM_TESTOSTERONE_LEVEL": "Increased serum testosterone level", "HP_INCREASED_SERUM_PYRUVATE": "", "HP_INCREASED_SKULL_OSSIFICATION": "Increased skull ossification", "HP_INCREASED_SULFUR_AMINO_ACID_LEVEL_IN_URINE": "Increased sulfur amino acid level in urine", "HP_INCREASED_TOTAL_BILIRUBIN": "Increased total bilirubin", "HP_INCREASED_THETA_FREQUENCY_ACTIVITY_IN_EEG": "Increased theta frequency activity in EEG", "HP_INCREASED_T_CELL_COUNT": "", "HP_INCREASED_SUSCEPTIBILITY_TO_FRACTURES": "Increased susceptibility to fractures", "HP_INCREASED_URINARY_PORPHOBILINOGEN": "Increased urinary porphobilinogen", "HP_INCREASED_URINARY_POTASSIUM": "Increased urinary potassium", "HP_INCREASED_URINARY_NON_PROTEINOGENIC_AMINO_ACID_LEVEL": "Increased urinary non-proteinogenic amino acid level", "HP_INCREASED_URINE_PROTEINOGENIC_AMINO_ACID_DERIVATIVE_LEVEL": "Increased urine proteinogenic amino acid derivative level", "HP_INCREASED_VERTEBRAL_HEIGHT": "Increased vertebral height", "HP_INEFFECTIVE_ESOPHAGEAL_PERISTALSIS": "Ineffective esophageal peristalsis", "HP_INERTIA": "Inertia", "HP_INCREASED_WAIST_TO_HIP_RATIO": "Increased waist to hip ratio", "HP_INFANTILE_AXIAL_HYPOTONIA": "", "HP_INFANTILE_ENCEPHALOPATHY": "Infantile encephalopathy", "HP_INFANTILE_MUSCULAR_HYPOTONIA": "", "HP_INFANTILE_SENSORINEURAL_HEARING_IMPAIRMENT": "Infantile sensorineural hearing impairment", "HP_INFECTION_FOLLOWING_LIVE_VACCINATION": "Infection following live vaccination", "HP_INFERIOR_CEREBELLAR_VERMIS_HYPOPLASIA": "Inferior cerebellar vermis hypoplasia", "HP_INFECTIOUS_ENCEPHALITIS": "Infectious encephalitis", "HP_INFANTILE_SPASMS": "Infantile spasms", "HP_INFLAMMATION_OF_THE_LARGE_INTESTINE": "Inflammation of the large intestine", "HP_INFLEXIBLE_ADHERENCE_TO_ROUTINES": "", "HP_INFLAMMATORY_ABNORMALITY_OF_THE_EYE": "Inflammatory abnormality of the eye", "HP_INFRA_ORBITAL_CREASE": "Infra-orbital crease", "HP_INFERTILITY": "Infertility", "HP_INGUINAL_FRECKLING": "Inguinal freckling", "HP_INFANTILE_ONSET": "Infantile onset", "HP_INSIDIOUS_ONSET": "Insidious onset", "HP_INSPIRATORY_STRIDOR": "Inspiratory stridor", "HP_INSOMNIA": "Insomnia", "HP_INGUINAL_HERNIA": "Inguinal hernia", "HP_INSULINOMA": "", "HP_INHERITANCE_QUALIFIER": "Inheritance qualifier", "HP_INSULIN_RESISTANT_DIABETES_MELLITUS": "Insulin-resistant diabetes mellitus", "HP_INTELLECTUAL_DISABILITY_MILD": "", "HP_INTELLECTUAL_DISABILITY_BORDERLINE": "", "HP_INSULIN_RESISTANCE": "Insulin resistance", "HP_INTELLECTUAL_DISABILITY_PROFOUND": "", "HP_INTELLECTUAL_DISABILITY_MODERATE": "", "HP_INTELLECTUAL_DISABILITY_SEVERE": "", "HP_INTELLECTUAL_DISABILITY_PROGRESSIVE": "", "HP_INTERHEMISPHERIC_CYST": "Interhemispheric cyst", "HP_INTERCOSTAL_MUSCLE_WEAKNESS": "Intercostal muscle weakness", "HP_INTERMEDIATE_YOUNG_ADULT_ONSET": "Intermediate young adult onset", "HP_INTERMITTENT_CLAUDICATION": "Intermittent claudication", "HP_INTERMITTENT_DIARRHEA": "Intermittent diarrhea", "HP_INTERMITTENT_EPISODES_OF_RESPIRATORY_INSUFFICIENCY_DUE_TO_MUSCLE_WEAKNESS": "Intermittent episodes of respiratory insufficiency due to muscle weakness", "HP_INTERMITTENT_HYPERVENTILATION": "Intermittent hyperventilation", "HP_INTERMITTENT_JAUNDICE": "Intermittent jaundice", "HP_INTERICTAL_EEG_ABNORMALITY": "Interictal EEG abnormality", "HP_INTERMITTENT_THROMBOCYTOPENIA": "Intermittent thrombocytopenia", "HP_INTEROSSEUS_MUSCLE_ATROPHY": "Interosseus muscle atrophy", "HP_INTERNALLY_NUCLEATED_SKELETAL_MUSCLE_FIBERS": "Internally nucleated skeletal muscle fibers", "HP_INTERPHALANGEAL_JOINT_EROSIONS": "Interphalangeal joint erosions", "HP_INTERRUPTED_AORTIC_ARCH": "Interrupted aortic arch", "HP_INTERRUPTED_INFERIOR_VENA_CAVA_WITH_AZYGOUS_CONTINUATION": "Interrupted inferior vena cava with azygous continuation", "HP_INTERSTITIAL_CARDIAC_FIBROSIS": "Interstitial cardiac fibrosis", "HP_INTERSTITIAL_PNEUMONITIS": "Interstitial pneumonitis", "HP_INTERVERTEBRAL_DISK_DEGENERATION": "Intervertebral disk degeneration", "HP_INTERVERTEBRAL_SPACE_NARROWING": "Intervertebral space narrowing", "HP_INTESTINAL_CARCINOID": "", "HP_INTESTINAL_BLEEDING": "Intestinal bleeding", "HP_INTESTINAL_ATRESIA": "Intestinal atresia", "HP_INTESTINAL_HYPOPLASIA": "Intestinal hypoplasia", "HP_INTESTINAL_LYMPHANGIECTASIA": "Intestinal lymphangiectasia", "HP_INTESTINAL_FISTULA": "Intestinal fistula", "HP_INTESTINAL_PERFORATION": "Intestinal perforation", "HP_INTESTINAL_POLYP": "Intestinal polyp", "HP_INTRAALVEOLAR_PHOSPHOLIPID_ACCUMULATION": "Intraalveolar phospholipid accumulation", "HP_INTESTINAL_MALROTATION": "Intestinal malrotation", "HP_INTRACELLULAR_ACCUMULATION_OF_AUTOFLUORESCENT_LIPOPIGMENT_STORAGE_MATERIAL": "", "HP_INTESTINAL_PSEUDO_OBSTRUCTION": "Intestinal pseudo-obstruction", "HP_INTRACEREBRAL_PERIVENTRICULAR_CALCIFICATIONS": "Intracerebral periventricular calcifications", "HP_INTRACTABLE_DIARRHEA": "Intractable diarrhea", "HP_INTRAHEPATIC_BILIARY_ATRESIA": "Intrahepatic biliary atresia", "HP_INTRAHEPATIC_BILE_DUCT_DILATATION": "Intrahepatic bile duct dilatation", "HP_INTRACRANIAL_HEMORRHAGE": "Intracranial hemorrhage", "HP_INTRAMUSCULAR_HEMATOMA": "Intramuscular hematoma", "HP_INTRAVENTRICULAR_HEMORRHAGE": "Intraventricular hemorrhage", "HP_INTRA_EPIDERMAL_BLISTERING": "Intra-epidermal blistering", "HP_INTRA_ORAL_HYPERPIGMENTATION": "Intra-oral hyperpigmentation", "HP_INTRINSIC_HAND_MUSCLE_ATROPHY": "Intrinsic hand muscle atrophy", "HP_INTUSSUSCEPTION": "Intussusception", "HP_INTRAUTERINE_GROWTH_RETARDATION": "Intrauterine growth retardation", "HP_INVERTED_NIPPLES": "Inverted nipples", "HP_INVOLUNTARY_VOCALIZATION": "Involuntary vocalization", "HP_IRIDOCYCLITIS": "Iridocyclitis", "HP_IRIDODONESIS": "Iridodonesis", "HP_IRIS_ATROPHY": "Iris atrophy", "HP_IRIS_TRANSILLUMINATION_DEFECT": "Iris transillumination defect", "HP_IRIS_HYPOPIGMENTATION": "Iris hypopigmentation", "HP_INVOLUNTARY_MOVEMENTS": "Involuntary movements", "HP_IRIS_COLOBOMA": "Iris coloboma", "HP_IRON_ACCUMULATION_IN_BRAIN": "Iron accumulation in brain", "HP_IRREGULARLY_SHAPED_SPERM_TAIL": "Irregularly shaped sperm tail", "HP_IRREGULAR_ACETABULAR_ROOF": "Irregular acetabular roof", "HP_IRON_DEFICIENCY_ANEMIA": "Iron deficiency anemia", "HP_IRREGULAR_CAPITAL_FEMORAL_EPIPHYSIS": "Irregular capital femoral epiphysis", "HP_IRREGULAR_DENTITION": "Irregular dentition", "HP_IRREGULAR_EPIPHYSES": "Irregular epiphyses", "HP_IRREGULAR_FEMORAL_EPIPHYSIS": "Irregular femoral epiphysis", "HP_IRREGULAR_ILIAC_CREST": "Irregular iliac crest", "HP_IRREGULAR_HYPERPIGMENTATION": "Irregular hyperpigmentation", "HP_IRREGULAR_VERTEBRAL_ENDPLATES": "Irregular vertebral endplates", "HP_IRREGULAR_MENSTRUATION": "Irregular menstruation", "HP_IRRITABILITY": "", "HP_IVORY_EPIPHYSES_OF_THE_PHALANGES_OF_THE_HAND": "Ivory epiphyses of the phalanges of the hand", "HP_ISOMERISM": "Isomerism", "HP_IVORY_EPIPHYSES": "Ivory epiphyses", "HP_JERKY_HEAD_MOVEMENTS": "Jerky head movements", "HP_JAW_HYPERREFLEXIA": "Jaw hyperreflexia", "HP_JAUNDICE": "Jaundice", "HP_JERKY_OCULAR_PURSUIT_MOVEMENTS": "Jerky ocular pursuit movements", "HP_JOINT_CONTRACTURE_OF_THE_4TH_FINGER": "Joint contracture of the 4th finger", "HP_JOINT_CONTRACTURE_OF_THE_5TH_FINGER": "Joint contracture of the 5th finger", "HP_JOINT_HEMORRHAGE": "Joint hemorrhage", "HP_JOINT_SUBLUXATION": "Joint subluxation", "HP_JOINT_DISLOCATION": "Joint dislocation", "HP_JUNCTIONAL_ECTOPIC_TACHYCARDIA": "Junctional ectopic tachycardia", "HP_JOINT_STIFFNESS": "Joint stiffness", "HP_JOINT_CONTRACTURE_OF_THE_HAND": "Joint contracture of the hand", "HP_JOINT_HYPERMOBILITY": "Joint hypermobility", "HP_JUVENILE_CATARACT": "Juvenile cataract", "HP_JOINT_SWELLING": "Joint swelling", "HP_JUVENILE_ASEPTIC_NECROSIS": "Juvenile aseptic necrosis", "HP_JUVENILE_MYELOMONOCYTIC_LEUKEMIA": "Juvenile myelomonocytic leukemia", "HP_JUVENILE_RHEUMATOID_ARTHRITIS": "Juvenile rheumatoid arthritis", "HP_KELOIDS": "Keloids", "HP_J_SHAPED_SELLA_TURCICA": "J-shaped sella turcica", "HP_KERATAN_SULFATE_EXCRETION_IN_URINE": "Keratan sulfate excretion in urine", "HP_KERATOACANTHOMA": "Keratoacanthoma", "HP_KERATITIS": "Keratitis", "HP_KERATOSIS_PILARIS": "Keratosis pilaris", "HP_KERATOCONJUNCTIVITIS": "Keratoconjunctivitis", "HP_KETOACIDOSIS": "Ketoacidosis", "HP_JUVENILE_ONSET": "Juvenile onset", "HP_KETOTIC_HYPOGLYCEMIA": "Ketotic hypoglycemia", "HP_KETONURIA": "Ketonuria", "HP_KINKED_BRAINSTEM": "Kinked brainstem", "HP_KETOSIS": "Ketosis", "HP_KINETIC_TREMOR": "Kinetic tremor", "HP_KNEE_CLONUS": "Knee clonus", "HP_KNEE_DISLOCATION": "Knee dislocation", "HP_KNEE_JOINT_HYPERMOBILITY": "Knee joint hypermobility", "HP_KNEE_CONTRACTURE": "Knee contracture", "HP_KNEE_PAIN": "Knee pain", "HP_KNEE_OSTEOARTHRITIS": "Knee osteoarthritis", "HP_KNUCKLE_PAD": "Knuckle pad", "HP_LABIAL_HYPERTROPHY": "Labial hypertrophy", "HP_KYPHOSCOLIOSIS": "Kyphoscoliosis", "HP_LACK_OF_INSIGHT": "Lack of insight", "HP_LACK_OF_SKIN_ELASTICITY": "Lack of skin elasticity", "HP_LACK_OF_T_CELL_FUNCTION": "", "HP_LACRIMAL_DUCT_STENOSIS": "Lacrimal duct stenosis", "HP_LACRIMAL_DUCT_APLASIA": "Lacrimal duct aplasia", "HP_LACRIMAL_DUCT_ATRESIA": "Lacrimal duct atresia", "HP_KYPHOSIS": "Kyphosis", "HP_LACRIMATION_ABNORMALITY": "Lacrimation abnormality", "HP_LACTOSE_INTOLERANCE": "Lactose intolerance", "HP_LACTICACIDURIA": "Lacticaciduria", "HP_LAGOPHTHALMOS": "Lagophthalmos", "HP_LACUNAR_STROKE": "Lacunar stroke", "HP_LACTIC_ACIDOSIS": "Lactic acidosis", "HP_LAMELLAR_CATARACT": "Lamellar cataract", "HP_LAMBDOIDAL_CRANIOSYNOSTOSIS": "Lambdoidal craniosynostosis", "HP_LARGE_CAFE_AU_LAIT_MACULES_WITH_IRREGULAR_MARGINS": "", "HP_LARGE_CENTRAL_VISUAL_FIELD_DEFECT": "", "HP_LARGE_EARLOBE": "Large earlobe", "HP_LARGE_FLESHY_EARS": "Large fleshy ears", "HP_LARGE_FOREHEAD": "Large forehead", "HP_LARGE_FACE": "Large face", "HP_LARGE_FOR_GESTATIONAL_AGE": "Large for gestational age", "HP_LARGE_ILIAC_WING": "Large iliac wing", "HP_LANGUAGE_IMPAIRMENT": "Language impairment", "HP_LARGE_HANDS": "Large hands", "HP_LARGE_INTESTINAL_POLYPOSIS": "Large intestinal polyposis", "HP_LARGE_FORAMEN_MAGNUM": "Large foramen magnum", "HP_LARGE_JOINT_HYPERMOBILTY": "Large joint hypermobilty", "HP_LARGE_FONTANELLES": "Large fontanelles", "HP_LARGE_POSTERIOR_FONTANELLE": "Large posterior fontanelle", "HP_LARGE_PLACENTA": "Large placenta", "HP_LARYNGEAL_CARCINOMA": "Laryngeal carcinoma", "HP_LARGE_SELLA_TURCICA": "Large sella turcica", "HP_LARYNGEAL_CLEFT": "Laryngeal cleft", "HP_LARYNGEAL_DYSTONIA": "Laryngeal dystonia", "HP_LARYNGEAL_HYPOPLASIA": "Laryngeal hypoplasia", "HP_LARYNGEAL_EDEMA": "Laryngeal edema", "HP_LARYNGEAL_STENOSIS": "Laryngeal stenosis", "HP_LARYNGEAL_STRIDOR": "Laryngeal stridor", "HP_LARYNGOTRACHEAL_STENOSIS": "Laryngotracheal stenosis", "HP_LARYNGOMALACIA": "Laryngomalacia", "HP_LARYNGOTRACHEOMALACIA": "Laryngotracheomalacia", "HP_LATERAL_CLAVICLE_HOOK": "Lateral clavicle hook", "HP_LATE_FIRST_TRIMESTER_ONSET": "Late first trimester onset", "HP_LATERAL_VENTRICLE_DILATATION": "Lateral ventricle dilatation", "HP_LATE_ONSET_PROXIMAL_MUSCLE_WEAKNESS": "Late-onset proximal muscle weakness", "HP_LEBER_OPTIC_ATROPHY": "Leber optic atrophy", "HP_LATE_YOUNG_ADULT_ONSET": "Late young adult onset", "HP_LATE_ONSET": "Late onset", "HP_LEFT_ANTERIOR_FASCICULAR_BLOCK": "Left anterior fascicular block", "HP_LEFT_BUNDLE_BRANCH_BLOCK": "Left bundle branch block", "HP_LEFT_TO_RIGHT_SHUNT": "Left-to-right shunt", "HP_LEFT_SUPERIOR_VENA_CAVA_DRAINING_TO_CORONARY_SINUS": "Left superior vena cava draining to coronary sinus", "HP_LEFT_VENTRICULAR_DIASTOLIC_DYSFUNCTION": "Left ventricular diastolic dysfunction", "HP_LEFT_VENTRICULAR_NONCOMPACTION_CARDIOMYOPATHY": "Left ventricular noncompaction cardiomyopathy", "HP_LEFT_VENTRICULAR_HYPERTROPHY": "Left ventricular hypertrophy", "HP_LEFT_VENTRICULAR_OUTFLOW_TRACT_OBSTRUCTION": "Left ventricular outflow tract obstruction", "HP_LEFT_VENTRICULAR_SYSTOLIC_DYSFUNCTION": "Left ventricular systolic dysfunction", "HP_LEG_MUSCLE_STIFFNESS": "Leg muscle stiffness", "HP_LEG_DYSTONIA": "Leg dystonia", "HP_LEIOMYOSARCOMA": "Leiomyosarcoma", "HP_LENS_SUBLUXATION": "Lens subluxation", "HP_LENS_LUXATION": "Lens luxation", "HP_LENTICONUS": "Lenticonus", "HP_LETHAL_SKELETAL_DYSPLASIA": "Lethal skeletal dysplasia", "HP_LEUKOCYTOSIS": "", "HP_LEUKOCORIA": "Leukocoria", "HP_LETHARGY": "Lethargy", "HP_LEUKEMIA": "Leukemia", "HP_LEUKONYCHIA": "Leukonychia", "HP_LEUKODYSTROPHY": "Leukodystrophy", "HP_LICHENIFICATION": "Lichenification", "HP_LEUKOPENIA": "", "HP_LEWY_BODIES": "Lewy bodies", "HP_LEUKOENCEPHALOPATHY": "Leukoencephalopathy", "HP_LIMBAL_DERMOID": "Limbal dermoid", "HP_LIMBAL_STEM_CELL_DEFICIENCY": "Limbal stem cell deficiency", "HP_LIMB_DYSMETRIA": "Limb dysmetria", "HP_LIMB_FASCICULATIONS": "Limb fasciculations", "HP_LIMB_ATAXIA": "Limb ataxia", "HP_LIMB_DYSTONIA": "Limb dystonia", "HP_LIMB_GIRDLE_MUSCULAR_DYSTROPHY": "Limb-girdle muscular dystrophy", "HP_LIMB_GIRDLE_MUSCLE_WEAKNESS": "Limb-girdle muscle weakness", "HP_LIMB_HYPERTONIA": "Limb hypertonia", "HP_LIMB_MYOCLONUS": "Limb myoclonus", "HP_LIMB_GIRDLE_MUSCLE_ATROPHY": "Limb-girdle muscle atrophy", "HP_LIMB_PAIN": "Limb pain", "HP_LIMB_TREMOR": "Limb tremor", "HP_LIMB_MUSCLE_WEAKNESS": "Limb muscle weakness", "HP_LIMB_UNDERGROWTH": "Limb undergrowth", "HP_LIMITATION_OF_KNEE_MOBILITY": "Limitation of knee mobility", "HP_LIMB_JOINT_CONTRACTURE": "Limb joint contracture", "HP_LIMITATION_OF_MOVEMENT_AT_ANKLES": "Limitation of movement at ankles", "HP_LIMITED_ELBOW_FLEXION": "Limited elbow flexion", "HP_LIMITATION_OF_JOINT_MOBILITY": "Limitation of joint mobility", "HP_LIMITED_ELBOW_EXTENSION": "Limited elbow extension", "HP_LIMITED_ELBOW_MOVEMENT": "Limited elbow movement", "HP_LIMITED_EXTRAOCULAR_MOVEMENTS": "Limited extraocular movements", "HP_LIMITED_HIP_EXTENSION": "Limited hip extension", "HP_LIMITED_KNEE_EXTENSION": "Limited knee extension", "HP_LIMITED_HIP_MOVEMENT": "Limited hip movement", "HP_LIMITED_KNEE_FLEXION": "Limited knee flexion", "HP_LIMITED_NECK_RANGE_OF_MOTION": "Limited neck range of motion", "HP_LIMITED_PRONATION_SUPINATION_OF_FOREARM": "Limited pronation/supination of forearm", "HP_LIMITED_WRIST_MOVEMENT": "", "HP_LINEAR_ARRAYS_OF_MACULAR_HYPERKERATOSES_IN_FLEXURAL_AREAS": "Linear arrays of macular hyperkeratoses in flexural areas", "HP_LINGUAL_DYSTONIA": "Lingual dystonia", "HP_LIPOMA": "Lipoma", "HP_LIPOATROPHY": "Lipoatrophy", "HP_LIP_PIT": "Lip pit", "HP_LIPEMIA_RETINALIS": "Lipemia retinalis", "HP_LIPODYSTROPHY": "Lipodystrophy", "HP_LIPOMATOUS_TUMOR": "Lipomatous tumor", "HP_LIP_TELANGIECTASIA": "Lip telangiectasia", "HP_LIVEDO": "Livedo", "HP_LIVER_ABSCESS": "Liver abscess", "HP_LISSENCEPHALY": "Lissencephaly", "HP_LOCALIZED_HIRSUTISM": "Localized hirsutism", "HP_LIVEDO_RETICULARIS": "", "HP_LOBAR_HOLOPROSENCEPHALY": "Lobar holoprosencephaly", "HP_LOCALIZED_OSTEOPOROSIS": "Localized osteoporosis", "HP_LOBULATED_TONGUE": "Lobulated tongue", "HP_LONG_CLAVICLES": "Long clavicles", "HP_LONG_EAR": "Long ear", "HP_LONG_EYELASHES": "Long eyelashes", "HP_LONG_HALLUX": "Long hallux", "HP_LONG_FOOT": "Long foot", "HP_LONG_NECK": "Long neck", "HP_LONG_FINGERS": "Long fingers", "HP_LONG_NASAL_BRIDGE": "Long nasal bridge", "HP_LOCALIZED_SKIN_LESION": "Localized skin lesion", "HP_LONG_PALM": "Long palm", "HP_LONG_NOSE": "Long nose", "HP_LONG_PENIS": "Long penis", "HP_LONG_PALPEBRAL_FISSURE": "Long palpebral fissure", "HP_LONG_THORAX": "Long thorax", "HP_LONG_THUMB": "Long thumb", "HP_LONG_UPPER_LIP": "Long upper lip", "HP_LONG_TOE": "Long toe", "HP_LOP_EAR": "Lop ear", "HP_LONG_PHILTRUM": "Long philtrum", "HP_LOSS_OF_AMBULATION": "Loss of ambulation", "HP_LOSS_OF_PURKINJE_CELLS_IN_THE_CEREBELLAR_VERMIS": "Loss of Purkinje cells in the cerebellar vermis", "HP_LOSS_OF_EYELASHES": "Loss of eyelashes", "HP_LOSS_OF_CONSCIOUSNESS": "Loss of consciousness", "HP_LOSS_OF_SPEECH": "Loss of speech", "HP_LOSS_OF_SUBCUTANEOUS_ADIPOSE_TISSUE_IN_LIMBS": "Loss of subcutaneous adipose tissue in limbs", "HP_LOSS_OF_VOICE": "Loss of voice", "HP_LOWER_EYELID_COLOBOMA": "Lower eyelid coloboma", "HP_LOWER_LIMB_AMYOTROPHY": "Lower limb amyotrophy", "HP_LOWER_EXTREMITY_JOINT_DISLOCATION": "Lower extremity joint dislocation", "HP_LOWER_LIMB_ASYMMETRY": "Lower limb asymmetry", "HP_LOWER_LIMB_HYPERREFLEXIA": "Lower limb hyperreflexia", "HP_LOWER_LIMB_HYPERTONIA": "Lower limb hypertonia", "HP_LOWER_LIMB_METAPHYSEAL_IRREGULARITY": "Lower-limb metaphyseal irregularity", "HP_LOWER_LIMB_JOINT_CONTRACTURE": "Lower-limb joint contracture", "HP_LOWER_LIMB_PAIN": "Lower limb pain", "HP_LOWER_LIMB_MUSCLE_WEAKNESS": "Lower limb muscle weakness", "HP_LOWER_LIMB_UNDERGROWTH": "Lower limb undergrowth", "HP_LOWER_LIMB_SPASTICITY": "Lower limb spasticity", "HP_LOW_1_MINUTE_APGAR_SCORE": "Low 1-minute APGAR score", "HP_LOW_ALKALINE_PHOSPHATASE": "", "HP_LOW_APGAR_SCORE": "Low APGAR score", "HP_LOW_BACK_PAIN": "Low back pain", "HP_LOW_ANTERIOR_HAIRLINE": "Low anterior hairline", "HP_LOW_FRUSTRATION_TOLERANCE": "Low frustration tolerance", "HP_LOW_GRADE_FEVER": "Low-grade fever", "HP_LOW_MOLECULAR_WEIGHT_PROTEINURIA": "Low-molecular-weight proteinuria", "HP_LOW_HANGING_COLUMELLA": "Low hanging columella", "HP_LOW_INSERTION_OF_COLUMELLA": "Low insertion of columella", "HP_LOW_PLASMA_CITRULLINE": "Low plasma citrulline", "HP_LOW_SELF_ESTEEM": "Low self-esteem", "HP_LOW_SERUM_CALCITRIOL": "Low serum calcitriol", "HP_LOW_SET_NIPPLES": "Low-set nipples", "HP_LOW_SET_POSTERIORLY_ROTATED_EARS": "", "HP_LUMBAR_HYPERLORDOSIS": "Lumbar hyperlordosis", "HP_LUMBAR_SCOLIOSIS": "Lumbar scoliosis", "HP_LUPUS_ANTICOAGULANT": "Lupus anticoagulant", "HP_LUMBAR_KYPHOSIS": "Lumbar kyphosis", "HP_LUPUS_NEPHRITIS": "Lupus nephritis", "HP_LYMPHANGIECTASIS": "Lymphangiectasis", "HP_LYMPHADENITIS": "Lymphadenitis", "HP_LOW_SET_EARS": "Low-set ears", "HP_LYMPHANGIOMA": "Lymphangioma", "HP_LYMPHEDEMA": "Lymphedema", "HP_LYMPHOPROLIFERATIVE_DISORDER": "Lymphoproliferative disorder", "HP_LYMPHOCYTOSIS": "", "HP_LYMPHOPENIA": "", "HP_LYMPHOMA": "Lymphoma", "HP_LYMPH_NODE_HYPOPLASIA": "Lymph node hypoplasia", "HP_MACROCEPHALY": "", "HP_MACROCEPHALY_AT_BIRTH": "Macrocephaly at birth", "HP_MACROCYTIC_ANEMIA": "Macrocytic anemia", "HP_MACRODONTIA": "Macrodontia", "HP_MACRODACTYLY": "", "HP_MACROORCHIDISM": "Macroorchidism", "HP_MACRODONTIA_OF_PERMANENT_MAXILLARY_CENTRAL_INCISOR": "Macrodontia of permanent maxillary central incisor", "HP_MACROTHROMBOCYTOPENIA": "Macrothrombocytopenia", "HP_MACROSCOPIC_HEMATURIA": "Macroscopic hematuria", "HP_MACROGLOSSIA": "Macroglossia", "HP_MACROVESICULAR_HEPATIC_STEATOSIS": "Macrovesicular hepatic steatosis", "HP_MACULAR_COLOBOMA": "", "HP_MACULAR_ATROPHY": "Macular atrophy", "HP_MACULAR_DEGENERATION": "Macular degeneration", "HP_MACROTIA": "Macrotia", "HP_MACULAR_DYSTROPHY": "Macular dystrophy", "HP_MACULAR_DRUSEN": "Macular drusen", "HP_MACULAR_HYPERPIGMENTATION": "Macular hyperpigmentation", "HP_MACULAR_EDEMA": "", "HP_MACULAR_HYPOPIGMENTATION": "Macular hypopigmentation", "HP_MACULAR_HYPOPLASIA": "Macular hypoplasia", "HP_MACULAR_SCAR": "Macular scar", "HP_MACULAR_PURPURA": "Macular purpura", "HP_MADELUNG_DEFORMITY": "Madelung deformity", "HP_MACULAR_THICKENING": "Macular thickening", "HP_MALAR_PROMINENCE": "Malar prominence", "HP_MACULE": "Macule", "HP_MALABSORPTION": "Malabsorption", "HP_MALAR_RASH": "Malar rash", "HP_MALE_HYPOGONADISM": "Male hypogonadism", "HP_MALAR_FLATTENING": "Malar flattening", "HP_MALE_PSEUDOHERMAPHRODITISM": "Male pseudohermaphroditism", "HP_MALE_REPRODUCTIVE_SYSTEM_NEOPLASM": "Male reproductive system neoplasm", "HP_MALE_SEXUAL_DYSFUNCTION": "Male sexual dysfunction", "HP_MALFORMATION_OF_THE_HEPATIC_DUCTAL_PLATE": "Malformation of the hepatic ductal plate", "HP_MALIGNANT_GASTROINTESTINAL_TRACT_TUMORS": "", "HP_MALIGNANT_GENITOURINARY_TRACT_TUMOR": "Malignant genitourinary tract tumor", "HP_MALIGNANT_HYPERTHERMIA": "Malignant hyperthermia", "HP_MALROTATION_OF_SMALL_BOWEL": "Malrotation of small bowel", "HP_MALIGNANT_NEOPLASM_OF_THE_CENTRAL_NERVOUS_SYSTEM": "Malignant neoplasm of the central nervous system", "HP_MALNUTRITION": "Malnutrition", "HP_MANDIBULAR_APLASIA": "Mandibular aplasia", "HP_MARCUS_GUNN_JAW_WINKING_SYNKINESIS": "Marcus Gunn jaw winking synkinesis", "HP_MASTOIDITIS": "Mastoiditis", "HP_MASK_LIKE_FACIES": "Mask-like facies", "HP_MATERNAL_AUTOIMMUNE_DISEASE": "Maternal autoimmune disease", "HP_MANDIBULAR_PROGNATHIA": "Mandibular prognathia", "HP_MATERNAL_HYPERTENSION": "Maternal hypertension", "HP_MECHANICAL_ILEUS": "", "HP_MATERNAL_DIABETES": "Maternal diabetes", "HP_MATURITY_ONSET_DIABETES_OF_THE_YOUNG": "Maturity-onset diabetes of the young", "HP_MECKEL_DIVERTICULUM": "Meckel diverticulum", "HP_MECONIUM_STAINED_AMNIOTIC_FLUID": "Meconium stained amniotic fluid", "HP_MEDIAL_FLARING_OF_THE_EYEBROW": "Medial flaring of the eyebrow", "HP_MEDIAN_CLEFT_PALATE": "Median cleft palate", "HP_MEDULLARY_NEPHROCALCINOSIS": "Medullary nephrocalcinosis", "HP_MEDIASTINAL_LYMPHADENOPATHY": "Mediastinal lymphadenopathy", "HP_MEDULLOBLASTOMA": "Medulloblastoma", "HP_MEDIAN_CLEFT_UPPER_LIP": "Median cleft upper lip", "HP_MEGACYSTIS": "Megacystis", "HP_MEGAKARYOCYTE_DYSPLASIA": "Megakaryocyte dysplasia", "HP_MEGAKARYOCYTOPENIA": "Megakaryocytopenia", "HP_MEGALENCEPHALY": "Megalencephaly", "HP_MEGALOBLASTIC_ANEMIA": "Megaloblastic anemia", "HP_MEGALOCORNEA": "Megalocornea", "HP_MELANOCYTIC_NEVUS": "Melanocytic nevus", "HP_MEMBRANOPROLIFERATIVE_GLOMERULONEPHRITIS": "Membranoproliferative glomerulonephritis", "HP_MELENA": "Melena", "HP_MELANOMA": "Melanoma", "HP_MENINGIOMA": "Meningioma", "HP_MENINGITIS": "Meningitis", "HP_MENINGOENCEPHALOCELE": "Meningoencephalocele", "HP_MEMORY_IMPAIRMENT": "Memory impairment", "HP_MENINGOCELE": "Meningocele", "HP_MENOMETRORRHAGIA": "Menometrorrhagia", "HP_MENORRHAGIA": "Menorrhagia", "HP_MESOAXIAL_FOOT_POLYDACTYLY": "Mesoaxial foot polydactyly", "HP_MESANGIAL_HYPERCELLULARITY": "", "HP_MESOAXIAL_HAND_POLYDACTYLY": "Mesoaxial hand polydactyly", "HP_MESOAXIAL_POLYDACTYLY": "Mesoaxial polydactyly", "HP_MENTAL_DETERIORATION": "Mental deterioration", "HP_MESOMELIC_ARM_SHORTENING": "Mesomelic arm shortening", "HP_MESOMELIC_LEG_SHORTENING": "Mesomelic leg shortening", "HP_MESOMELIA": "Mesomelia", "HP_METABOLIC_ALKALOSIS": "Metabolic alkalosis", "HP_METACARPOPHALANGEAL_JOINT_CONTRACTURE": "Metacarpophalangeal joint contracture", "HP_METABOLIC_ACIDOSIS": "Metabolic acidosis", "HP_METAPHYSEAL_CHONDRODYSPLASIA": "Metaphyseal chondrodysplasia", "HP_METAMORPHOPSIA": "Metamorphopsia", "HP_METAPHYSEAL_CUPPING": "Metaphyseal cupping", "HP_METAPHYSEAL_DYSPLASIA": "Metaphyseal dysplasia", "HP_METAPHYSEAL_SCLEROSIS": "Metaphyseal sclerosis", "HP_METAPHYSEAL_IRREGULARITY": "Metaphyseal irregularity", "HP_METAPHYSEAL_SPURS": "Metaphyseal spurs", "HP_METAPHYSEAL_STRIATIONS": "Metaphyseal striations", "HP_METATARSAL_SYNOSTOSIS": "Metatarsal synostosis", "HP_METAPHYSEAL_WIDENING": "Metaphyseal widening", "HP_METATARSUS_VALGUS": "Metatarsus valgus", "HP_METHEMOGLOBINEMIA": "Methemoglobinemia", "HP_METATARSUS_ADDUCTUS": "Metatarsus adductus", "HP_METHYLMALONIC_ACIDEMIA": "Methylmalonic acidemia", "HP_METHYLMALONIC_ACIDURIA": "Methylmalonic aciduria", "HP_METOPIC_SYNOSTOSIS": "Metopic synostosis", "HP_METRORRHAGIA": "Metrorrhagia", "HP_MICROANGIOPATHIC_HEMOLYTIC_ANEMIA": "Microangiopathic hemolytic anemia", "HP_MICROCEPHALIC_SPERM_HEAD": "Microcephalic sperm head", "HP_MICROCORNEA": "Microcornea", "HP_MICROCYTIC_ANEMIA": "Microcytic anemia", "HP_MICROGLOSSIA": "Microglossia", "HP_MICROGRAPHIA": "Micrographia", "HP_MICROLISSENCEPHALY": "Microlissencephaly", "HP_MICRODONTIA": "Microdontia", "HP_MICRONODULAR_CIRRHOSIS": "Micronodular cirrhosis", "HP_MICROMELIA": "Micromelia", "HP_MICROPHALLUS": "Microphallus", "HP_MICROPENIS": "Micropenis", "HP_MICROSCOPIC_HEMATURIA": "Microscopic hematuria", "HP_MICRORETROGNATHIA": "Microretrognathia", "HP_MICROTIA_FIRST_DEGREE": "Microtia, first degree", "HP_MICROTIA_THIRD_DEGREE": "Microtia, third degree", "HP_MICROPHTHALMIA": "Microphthalmia", "HP_MICROVESICULAR_HEPATIC_STEATOSIS": "Microvesicular hepatic steatosis", "HP_MIDLINE_DEFECT_OF_THE_NOSE": "Midline defect of the nose", "HP_MIDDLE_AGE_ONSET": "Middle age onset", "HP_MIDFACE_RETRUSION": "Midface retrusion", "HP_MIGRAINE_WITHOUT_AURA": "Migraine without aura", "HP_MIGRAINE_WITH_AURA": "Migraine with aura", "HP_MILD_HEARING_IMPAIRMENT": "Mild hearing impairment", "HP_MIGRAINE": "Migraine", "HP_MILDLY_ELEVATED_CREATINE_KINASE": "Mildly elevated creatine kinase", "HP_MILD_MICROCEPHALY": "Mild microcephaly", "HP_MILD_GLOBAL_DEVELOPMENTAL_DELAY": "Mild global developmental delay", "HP_MILD_MYOPIA": "Mild myopia", "HP_MILD_POSTNATAL_GROWTH_RETARDATION": "Mild postnatal growth retardation", "HP_MILD_PROTEINURIA": "Mild proteinuria", "HP_MILIA": "Milia", "HP_MILD_SHORT_STATURE": "Mild short stature", "HP_MINICORE_MYOPATHY": "Minicore myopathy", "HP_MINIMAL_CHANGE_GLOMERULONEPHRITIS": "Minimal change glomerulonephritis", "HP_MINIMAL_SUBCUTANEOUS_FAT": "Minimal subcutaneous fat", "HP_MISALIGNMENT_OF_INCISORS": "Misalignment of incisors", "HP_MITOCHONDRIAL_INHERITANCE": "Mitochondrial inheritance", "HP_MIOSIS": "Miosis", "HP_MISCARRIAGE": "Miscarriage", "HP_MITOCHONDRIAL_RESPIRATORY_CHAIN_DEFECTS": "Mitochondrial respiratory chain defects", "HP_MISSING_RIBS": "Missing ribs", "HP_MITOCHONDRIAL_MYOPATHY": "Mitochondrial myopathy", "HP_MITRAL_STENOSIS": "Mitral stenosis", "HP_MITRAL_ATRESIA": "Mitral atresia", "HP_MITRAL_VALVE_CALCIFICATION": "Mitral valve calcification", "HP_MITRAL_VALVE_PROLAPSE": "Mitral valve prolapse", "HP_MITTEN_DEFORMITY": "Mitten deformity", "HP_MIXED_DEMYELINATING_AND_AXONAL_POLYNEUROPATHY": "Mixed demyelinating and axonal polyneuropathy", "HP_MIXED_HYPO_AND_HYPERPIGMENTATION_OF_THE_SKIN": "Mixed hypo- and hyperpigmentation of the skin", "HP_MIXED_HEARING_IMPAIRMENT": "Mixed hearing impairment", "HP_MODERATELY_REDUCED_VISUAL_ACUITY": "Moderately reduced visual acuity", "HP_MODERATELY_SHORT_STATURE": "Moderately short stature", "HP_MODERATE_ALBUMINURIA": "Moderate albuminuria", "HP_MODERATE_GLOBAL_DEVELOPMENTAL_DELAY": "Moderate global developmental delay", "HP_MODERATE_MYOPIA": "Moderate myopia", "HP_MOLLUSCOID_PSEUDOTUMORS": "Molluscoid pseudotumors", "HP_MONOCHROMACY": "Monochromacy", "HP_MOLAR_TOOTH_SIGN_ON_MRI": "Molar tooth sign on MRI", "HP_MOON_FACIES": "Moon facies", "HP_MONOCYTOSIS": "", "HP_MONOCYTOPENIA": "", "HP_MONOTONIC_SPEECH": "Monotonic speech", "HP_MORNING_MYOCLONIC_JERKS": "Morning myoclonic jerks", "HP_MORNING_GLORY_ANOMALY": "Morning glory anomaly", "HP_MORTALITY_AGING": "", "HP_MOTOR_DETERIORATION": "Motor deterioration", "HP_MOTOR_AXONAL_NEUROPATHY": "Motor axonal neuropathy", "HP_MOTOR_REGRESSION": "Motor regression", "HP_MOTOR_POLYNEUROPATHY": "Motor polyneuropathy", "HP_MOTOR_NEURON_ATROPHY": "Motor neuron atrophy", "HP_MOTOR_TICS": "Motor tics", "HP_MOTOR_STEREOTYPY": "", "HP_MOTTLED_PIGMENTATION": "Mottled pigmentation", "HP_MOVEMENT_ABNORMALITY_OF_THE_TONGUE": "Movement abnormality of the tongue", "HP_MOTOR_DELAY": "Motor delay", "HP_MOYAMOYA_PHENOMENON": "Moyamoya phenomenon", "HP_MOTOR_SEIZURE": "Motor seizure", "HP_MUCOPOLYSACCHARIDURIA": "Mucopolysacchariduria", "HP_MULTIFOCAL_CEREBRAL_WHITE_MATTER_ABNORMALITIES": "Multifocal cerebral white matter abnormalities", "HP_MUCOSAL_TELANGIECTASIAE": "Mucosal telangiectasiae", "HP_MULTICYSTIC_KIDNEY_DYSPLASIA": "Multicystic kidney dysplasia", "HP_MULTIFOCAL_SEIZURES": "Multifocal seizures", "HP_MULTIFOCAL_EPILEPTIFORM_DISCHARGES": "Multifocal epileptiform discharges", "HP_MULTINODULAR_GOITER": "Multinodular goiter", "HP_MULTIPLE_BLADDER_DIVERTICULA": "", "HP_MULTIPLE_ENCHONDROMATOSIS": "Multiple enchondromatosis", "HP_MULTIPLE_CAFE_AU_LAIT_SPOTS": "Multiple cafe-au-lait spots", "HP_MULTIPLE_EPIPHYSEAL_DYSPLASIA": "Multiple epiphyseal dysplasia", "HP_MULTIPLE_IMPACTED_TEETH": "Multiple impacted teeth", "HP_MULTIPLE_GLOMERULAR_CYSTS": "Multiple glomerular cysts", "HP_MULTIPLE_GASTRIC_POLYPS": "Multiple gastric polyps", "HP_MULTIPLE_EXOSTOSES": "Multiple exostoses", "HP_MULTIPLE_JOINT_CONTRACTURES": "Multiple joint contractures", "HP_MULTIPLE_JOINT_DISLOCATION": "Multiple joint dislocation", "HP_MULTIPLE_MITOCHONDRIAL_DNA_DELETIONS": "Multiple mitochondrial DNA deletions", "HP_MULTIPLE_LENTIGINES": "Multiple lentigines", "HP_MULTIPLE_MYELOMA": "Multiple myeloma", "HP_MULTIPLE_LIPOMAS": "Multiple lipomas", "HP_MULTIPLE_PULMONARY_CYSTS": "Multiple pulmonary cysts", "HP_MULTIPLE_PRENATAL_FRACTURES": "Multiple prenatal fractures", "HP_MULTIPLE_RIB_FRACTURES": "Multiple rib fractures", "HP_MULTIPLE_RENAL_CYSTS": "Multiple renal cysts", "HP_MULTIPLE_SUTURE_CRANIOSYNOSTOSIS": "Multiple suture craniosynostosis", "HP_MUSCLE_ABNORMALITY_RELATED_TO_MITOCHONDRIAL_DYSFUNCTION": "Muscle abnormality related to mitochondrial dysfunction", "HP_MUSCLE_FIBER_NECROSIS": "Muscle fiber necrosis", "HP_MUSCLE_FIBER_INCLUSION_BODIES": "", "HP_MUSCLE_FIBER_ATROPHY": "Muscle fiber atrophy", "HP_MUSCLE_FIBER_CYTOPLASMATIC_INCLUSION_BODIES": "Muscle fiber cytoplasmatic inclusion bodies", "HP_MUSCLE_FIBER_SPLITTING": "Muscle fiber splitting", "HP_MUSCLE_FIBER_TUBULAR_INCLUSIONS": "Muscle fiber tubular inclusions", "HP_MUSCLE_FLACCIDITY": "Muscle flaccidity", "HP_MUSCLE_FIBRILLATION": "Muscle fibrillation", "HP_MUSCLE_STIFFNESS": "Muscle stiffness", "HP_MUSCLE_SPASM": "Muscle spasm", "HP_MUSCULAR_VENTRICULAR_SEPTAL_DEFECT": "Muscular ventricular septal defect", "HP_MUSCULAR_DYSTROPHY": "Muscular dystrophy", "HP_MYDRIASIS": "Mydriasis", "HP_MUTISM": "Mutism", "HP_MYELIN_OUTFOLDINGS": "Myelin outfoldings", "HP_MYALGIA": "Myalgia", "HP_MYELODYSPLASIA": "Myelodysplasia", "HP_MUSCLE_WEAKNESS": "Muscle weakness", "HP_MYELOID_LEUKEMIA": "Myeloid leukemia", "HP_MYELOFIBROSIS": "Myelofibrosis", "HP_MYELOPATHY": "Myelopathy", "HP_MYELOMENINGOCELE": "Myelomeningocele", "HP_MYOCARDIAL_FIBROSIS": "Myocardial fibrosis", "HP_MYELOPROLIFERATIVE_DISORDER": "Myeloproliferative disorder", "HP_MYOCARDITIS": "Myocarditis", "HP_MYOCLONIC_ABSENCE_SEIZURE": "Myoclonic absence seizure", "HP_MYOCLONIC_SPASMS": "Myoclonic spasms", "HP_MYOCLONIC_STATUS_EPILEPTICUS": "Myoclonic status epilepticus", "HP_MYOFIBER_DISARRAY": "Myofiber disarray", "HP_MYOFIBRILLAR_MYOPATHY": "Myofibrillar myopathy", "HP_MYOCLONIC_SEIZURE": "Myoclonic seizure", "HP_MYOGLOBINURIA": "Myoglobinuria", "HP_MYOKYMIA": "Myokymia", "HP_MYOCLONUS": "Myoclonus", "HP_MYOPATHIC_FACIES": "Myopathic facies", "HP_MYOPIC_ASTIGMATISM": "Myopic astigmatism", "HP_MYOPATHY": "Myopathy", "HP_MYOSITIS": "Myositis", "HP_MYOTONIA": "Myotonia", "HP_NAEVUS_FLAMMEUS_OF_THE_EYELID": "Naevus flammeus of the eyelid", "HP_NAIL_PITS": "Nail pits", "HP_MYOPIA": "Myopia", "HP_NAIL_DYSPLASIA": "Nail dysplasia", "HP_NAIL_DYSTROPHY": "Nail dystrophy", "HP_NARROW_FOOT": "Narrow foot", "HP_NARROW_FACE": "Narrow face", "HP_NARROW_FORAMEN_OBTURATORIUM": "Narrow foramen obturatorium", "HP_NARROW_INTERNAL_AUDITORY_CANAL": "Narrow internal auditory canal", "HP_NARROW_ILIAC_WING": "Narrow iliac wing", "HP_NARROW_JAW": "Narrow jaw", "HP_NARROW_FOREHEAD": "Narrow forehead", "HP_NARROW_NARIS": "Narrow naris", "HP_NARROW_NOSE": "Narrow nose", "HP_NARROW_NASAL_RIDGE": "Narrow nasal ridge", "HP_NARROW_NASAL_BRIDGE": "Narrow nasal bridge", "HP_NARROW_MOUTH": "Narrow mouth", "HP_NARROW_PALM": "Narrow palm", "HP_NARROW_PELVIS_BONE": "Narrow pelvis bone", "HP_NARROW_PALATE": "Narrow palate", "HP_NARROW_PALPEBRAL_FISSURE": "Narrow palpebral fissure", "HP_NARROW_VERTEBRAL_INTERPEDICULAR_DISTANCE": "Narrow vertebral interpedicular distance", "HP_NASAL_REGURGITATION": "Nasal regurgitation", "HP_NASAL_CONGESTION": "Nasal congestion", "HP_NASAL_DYSARTHRIA": "Nasal dysarthria", "HP_NASOGASTRIC_TUBE_FEEDING_IN_INFANCY": "Nasogastric tube feeding in infancy", "HP_NASOGASTRIC_TUBE_FEEDING": "Nasogastric tube feeding", "HP_NATAL_TOOTH": "Natal tooth", "HP_NASOLACRIMAL_DUCT_OBSTRUCTION": "Nasolacrimal duct obstruction", "HP_NAUSEA": "Nausea", "HP_NECK_FLEXOR_WEAKNESS": "Neck flexor weakness", "HP_NECK_PAIN": "Neck pain", "HP_NECROTIZING_ENTEROCOLITIS": "Necrotizing enterocolitis", "HP_NECK_MUSCLE_WEAKNESS": "Neck muscle weakness", "HP_NEGATIVISM": "Negativism", "HP_NEMALINE_BODIES": "Nemaline bodies", "HP_NAUSEA_AND_VOMITING": "Nausea and vomiting", "HP_NEONATAL_ASPHYXIA": "Neonatal asphyxia", "HP_NEONATAL_ALLOIMMUNE_THROMBOCYTOPENIA": "Neonatal alloimmune thrombocytopenia", "HP_NEONATAL_BREATHING_DYSREGULATION": "Neonatal breathing dysregulation", "HP_NEONATAL_HYPERBILIRUBINEMIA": "Neonatal hyperbilirubinemia", "HP_NEONATAL_DEATH": "Neonatal death", "HP_NEONATAL_HYPOGLYCEMIA": "Neonatal hypoglycemia", "HP_NEONATAL_OMPHALITIS": "Neonatal omphalitis", "HP_NEONATAL_INSULIN_DEPENDENT_DIABETES_MELLITUS": "Neonatal insulin-dependent diabetes mellitus", "HP_NEONATAL_HYPOTONIA": "Neonatal hypotonia", "HP_NEONATAL_SEIZURE": "Neonatal seizure", "HP_NEONATAL_SHORT_LIMB_SHORT_STATURE": "Neonatal short-limb short stature", "HP_NEONATAL_RESPIRATORY_DISTRESS": "Neonatal respiratory distress", "HP_NEOPLASIA_OF_THE_NASOPHARYNX": "Neoplasia of the nasopharynx", "HP_NEONATAL_ONSET": "Neonatal onset", "HP_NEOPLASM_OF_STRIATED_MUSCLE": "Neoplasm of striated muscle", "HP_NEOPLASM_OF_HEAD_AND_NECK": "Neoplasm of head and neck", "HP_NEOPLASM_OF_THE_ADRENAL_CORTEX": "Neoplasm of the adrenal cortex", "HP_NEOPLASM_OF_THE_ADRENAL_GLAND": "Neoplasm of the adrenal gland", "HP_NEOPLASM_OF_THE_AUTONOMIC_NERVOUS_SYSTEM": "Neoplasm of the autonomic nervous system", "HP_NEOPLASM_BY_HISTOLOGY": "Neoplasm by histology", "HP_NEOPLASM_OF_THE_EAR": "Neoplasm of the ear", "HP_NEOPLASM_OF_THE_BREAST": "Neoplasm of the breast", "HP_NEOPLASM_OF_THE_COLON": "Neoplasm of the colon", "HP_NEOPLASM": "Neoplasm", "HP_NEOPLASM_OF_THE_ENDOCRINE_SYSTEM": "Neoplasm of the endocrine system", "HP_NEOPLASM_OF_THE_GALLBLADDER": "Neoplasm of the gallbladder", "HP_NEOPLASM_OF_THE_EYE": "Neoplasm of the eye", "HP_NEOPLASM_OF_THE_HEART": "Neoplasm of the heart", "HP_NEOPLASM_OF_THE_INNER_EAR": "Neoplasm of the inner ear", "HP_NEOPLASM_OF_THE_LARGE_INTESTINE": "", "HP_NEOPLASM_OF_THE_LARYNX": "Neoplasm of the larynx", "HP_NEOPLASM_OF_THE_GASTROINTESTINAL_TRACT": "Neoplasm of the gastrointestinal tract", "HP_NEOPLASM_OF_THE_GENITOURINARY_TRACT": "Neoplasm of the genitourinary tract", "HP_NEOPLASM_OF_THE_LIVER": "Neoplasm of the liver", "HP_NEOPLASM_OF_THE_MALE_EXTERNAL_GENITALIA": "Neoplasm of the male external genitalia", "HP_NEOPLASM_OF_THE_LUNG": "Neoplasm of the lung", "HP_NEOPLASM_OF_THE_PARATHYROID_GLAND": "Neoplasm of the parathyroid gland", "HP_NEOPLASM_OF_THE_NERVOUS_SYSTEM": "Neoplasm of the nervous system", "HP_NEOPLASM_OF_THE_PANCREAS": "Neoplasm of the pancreas", "HP_NEOPLASM_OF_THE_ORAL_CAVITY": "Neoplasm of the oral cavity", "HP_NEOPLASM_OF_THE_PITUITARY_GLAND": "", "HP_NEOPLASM_OF_THE_PERIPHERAL_NERVOUS_SYSTEM": "Neoplasm of the peripheral nervous system", "HP_NEOPLASM_OF_THE_RECTUM": "Neoplasm of the rectum", "HP_NEOPLASM_OF_THE_RESPIRATORY_SYSTEM": "Neoplasm of the respiratory system", "HP_NEOPLASM_OF_THE_SMALL_INTESTINE": "Neoplasm of the small intestine", "HP_NEOPLASM_OF_THE_SKELETAL_SYSTEM": "Neoplasm of the skeletal system", "HP_NEOPLASM_OF_THE_SKIN": "Neoplasm of the skin", "HP_NEOPLASM_OF_THE_THYMUS": "", "HP_NEOPLASM_OF_THE_STOMACH": "Neoplasm of the stomach", "HP_NEOPLASM_OF_THE_TRACHEOBRONCHIAL_SYSTEM": "Neoplasm of the tracheobronchial system", "HP_NEOPLASM_OF_THE_THYROID_GLAND": "Neoplasm of the thyroid gland", "HP_NEOPLASM_OF_THE_TONGUE": "Neoplasm of the tongue", "HP_NEPHROCALCINOSIS": "Nephrocalcinosis", "HP_NEPHRITIS": "Nephritis", "HP_NEPHROGENIC_DIABETES_INSIPIDUS": "Nephrogenic diabetes insipidus", "HP_NEPHRONOPHTHISIS": "Nephronophthisis", "HP_NEPHROLITHIASIS": "Nephrolithiasis", "HP_NEPHROPATHY": "Nephropathy", "HP_NEPHROTIC_SYNDROME": "Nephrotic syndrome", "HP_NEURODEGENERATION": "Neurodegeneration", "HP_NEUROENDOCRINE_NEOPLASM": "Neuroendocrine neoplasm", "HP_NEUROFIBRILLARY_TANGLES": "Neurofibrillary tangles", "HP_NEURAL_TUBE_DEFECT": "Neural tube defect", "HP_NEUROFIBROMA": "Neurofibroma", "HP_NEUROGENIC_BLADDER": "Neurogenic bladder", "HP_NEUROINFLAMMATION": "Neuroinflammation", "HP_NEUROMA": "Neuroma", "HP_NEUROMUSCULAR_DYSPHAGIA": "Neuromuscular dysphagia", "HP_NEURONAL_LOSS_IN_THE_CEREBRAL_CORTEX": "Neuronal loss in the cerebral cortex", "HP_NEUROPATHIC_ARTHROPATHY": "Neuropathic arthropathy", "HP_NEURONAL_LOSS_IN_CENTRAL_NERVOUS_SYSTEM": "Neuronal loss in central nervous system", "HP_NEUROPATHIC_SPINAL_ARTHROPATHY": "Neuropathic spinal arthropathy", "HP_NEUTROPHILIA": "", "HP_NEUTROPENIA_IN_PRESENCE_OF_ANTI_NEUTROPIL_ANTIBODIES": "", "HP_NEVUS_FLAMMEUS_OF_THE_FOREHEAD": "Nevus flammeus of the forehead", "HP_NEVUS_SEBACEOUS": "Nevus sebaceous", "HP_NIGHT_SWEATS": "Night sweats", "HP_NEVUS": "Nevus", "HP_NOCTURNAL_HYPOVENTILATION": "Nocturnal hypoventilation", "HP_NOCTURIA": "Nocturia", "HP_NODULAR_CHANGES_AFFECTING_THE_EYELIDS": "Nodular changes affecting the eyelids", "HP_NOCTURNAL_SEIZURES": "Nocturnal seizures", "HP_NODULAR_REGENERATIVE_HYPERPLASIA_OF_LIVER": "Nodular regenerative hyperplasia of liver", "HP_NODULAR_GOITER": "Nodular goiter", "HP_NONCOMMUNICATING_HYDROCEPHALUS": "Noncommunicating hydrocephalus", "HP_NONCOMPACTION_CARDIOMYOPATHY": "Noncompaction cardiomyopathy", "HP_NONKETOTIC_HYPOGLYCEMIA": "Nonketotic hypoglycemia", "HP_NONPROGRESSIVE_CEREBELLAR_ATAXIA": "Nonprogressive cerebellar ataxia", "HP_NONPROGRESSIVE": "Nonprogressive", "HP_NONSPHEROCYTIC_HEMOLYTIC_ANEMIA": "Nonspherocytic hemolytic anemia", "HP_NONIMMUNE_HYDROPS_FETALIS": "Nonimmune hydrops fetalis", "HP_NONTUBERCULOUS_MYCOBACTERIAL_PULMONARY_INFECTION": "Nontuberculous mycobacterial pulmonary infection", "HP_NON_MEDULLARY_THYROID_CARCINOMA": "Non-medullary thyroid carcinoma", "HP_NON_CONVULSIVE_STATUS_EPILEPTICUS_WITHOUT_COMA": "Non-convulsive status epilepticus without coma", "HP_NON_MENDELIAN_INHERITANCE": "Non-Mendelian inheritance", "HP_NON_HODGKIN_LYMPHOMA": "Non-Hodgkin lymphoma", "HP_NON_MIDLINE_CLEFT_OF_THE_UPPER_LIP": "Non-midline cleft of the upper lip", "HP_NON_MIDLINE_CLEFT_PALATE": "Non-midline cleft palate", "HP_NON_SMALL_CELL_LUNG_CARCINOMA": "Non-small cell lung carcinoma", "HP_NON_PERIODIC_RECURRENT_FEVER": "", "HP_NON_OBSTRUCTIVE_AZOOSPERMIA": "Non-obstructive azoospermia", "HP_NORMAL_PRESSURE_HYDROCEPHALUS": "Normal pressure hydrocephalus", "HP_NORMAL_INTERICTAL_EEG": "Normal interictal EEG", "HP_NON_MOTOR_SEIZURE": "Non-motor seizure", "HP_NORMOCYTIC_ANEMIA": "Normocytic anemia", "HP_NREM_PARASOMNIA": "NREM parasomnia", "HP_NO_SOCIAL_INTERACTION": "No social interaction", "HP_NORMOCHROMIC_ANEMIA": "Normochromic anemia", "HP_NUCHAL_RIGIDITY": "Nuchal rigidity", "HP_NUCLEAR_CATARACT": "Nuclear cataract", "HP_NUMEROUS_NEVI": "Numerous nevi", "HP_NUMEROUS_PIGMENTED_FRECKLES": "Numerous pigmented freckles", "HP_NYSTAGMUS_INDUCED_HEAD_NODDING": "Nystagmus-induced head nodding", "HP_OBSESSIVE_COMPULSIVE_TRAIT": "Obsessive-compulsive trait", "HP_NYCTALOPIA": "Nyctalopia", "HP_OBSTRUCTIVE_AZOOSPERMIA": "Obstructive azoospermia", "HP_OCCIPITAL_CORTICAL_ATROPHY": "Occipital cortical atrophy", "HP_OBSTRUCTIVE_SLEEP_APNEA": "Obstructive sleep apnea", "HP_OCCIPITAL_MENINGOCELE": "Occipital meningocele", "HP_OCULAR_ALBINISM": "Ocular albinism", "HP_OCCIPITAL_ENCEPHALOCELE": "Occipital encephalocele", "HP_OCULAR_FLUTTER": "Ocular flutter", "HP_OCULAR_PAIN": "Ocular pain", "HP_OCULAR_ANTERIOR_SEGMENT_DYSGENESIS": "Ocular anterior segment dysgenesis", "HP_OCULOGYRIC_CRISIS": "Oculogyric crisis", "HP_OCULOMOTOR_APRAXIA": "Oculomotor apraxia", "HP_OCULOMOTOR_NERVE_PALSY": "Oculomotor nerve palsy", "HP_ODONTOGENIC_NEOPLASM": "Odontogenic neoplasm", "HP_OLIGOARTHRITIS": "Oligoarthritis", "HP_OLIGODACTYLY": "Oligodactyly", "HP_OLIGODONTIA": "Oligodontia", "HP_OLIGOSACCHARIDURIA": "Oligosacchariduria", "HP_OLIGOMENORRHEA": "Oligomenorrhea", "HP_OLIGOHYDRAMNIOS": "Oligohydramnios", "HP_OLIGOZOOSPERMIA": "Oligozoospermia", "HP_OLIGURIA": "Oliguria", "HP_OLIVOPONTOCEREBELLAR_ATROPHY": "Olivopontocerebellar atrophy", "HP_OLIVOPONTOCEREBELLAR_HYPOPLASIA": "Olivopontocerebellar hypoplasia", "HP_ONION_BULB_FORMATION": "Onion bulb formation", "HP_OMPHALOCELE": "Omphalocele", "HP_ONYCHOGRYPOSIS": "", "HP_ONYCHOGRYPOSIS_OF_FINGERNAIL": "", "HP_ONYCHOGRYPOSIS_OF_TOENAILS": "", "HP_ONYCHOLYSIS": "", "HP_ONYCHOMYCOSIS": "Onychomycosis", "HP_OOCYTE_ARREST_AT_METAPHASE_I": "", "HP_OPEN_ANGLE_GLAUCOMA": "Open angle glaucoma", "HP_OPEN_BITE": "Open bite", "HP_OPEN_OPERCULUM": "Open operculum", "HP_OPEN_MOUTH": "Open mouth", "HP_OPEN_NEURAL_TUBE_DEFECT": "Open neural tube defect", "HP_OPISTHOTONUS": "Opisthotonus", "HP_OPPORTUNISTIC_FUNGAL_INFECTION": "Opportunistic fungal infection", "HP_OPPORTUNISTIC_BACTERIAL_INFECTION": "Opportunistic bacterial infection", "HP_OPHTHALMOPARESIS": "Ophthalmoparesis", "HP_OPSOCLONUS": "Opsoclonus", "HP_OPPORTUNISTIC_INFECTION": "Opportunistic infection", "HP_OPTIC_DISC_COLOBOMA": "Optic disc coloboma", "HP_OPTIC_DISC_DRUSEN": "", "HP_OPTIC_DISC_HYPOPLASIA": "Optic disc hypoplasia", "HP_OPTIC_NERVE_COMPRESSION": "Optic nerve compression", "HP_OPTIC_NERVE_DYSPLASIA": "Optic nerve dysplasia", "HP_OPTIC_ATROPHY": "Optic atrophy", "HP_OPTIC_NERVE_MISROUTING": "Optic nerve misrouting", "HP_OPTIC_NERVE_GLIOMA": "Optic nerve glioma", "HP_OPTIC_DISC_PALLOR": "Optic disc pallor", "HP_ORAL_AVERSION": "Oral aversion", "HP_ORAL_CAVITY_BLEEDING": "Oral cavity bleeding", "HP_OPTIC_NEUROPATHY": "Optic neuropathy", "HP_ORAL_MUCOSAL_BLISTERS": "Oral mucosal blisters", "HP_ORAL_PHARYNGEAL_DYSPHAGIA": "Oral-pharyngeal dysphagia", "HP_ORAL_ULCER": "Oral ulcer", "HP_ORCHITIS": "Orchitis", "HP_ORGANIC_ACIDURIA": "Organic aciduria", "HP_OROTICACIDURIA": "Oroticaciduria", "HP_OROMANDIBULAR_DYSTONIA": "Oromandibular dystonia", "HP_OROMOTOR_APRAXIA": "Oromotor apraxia", "HP_OROFACIAL_DYSKINESIA": "Orofacial dyskinesia", "HP_OROPHARYNGEAL_SQUAMOUS_CELL_CARCINOMA": "Oropharyngeal squamous cell carcinoma", "HP_ORTHOKERATOSIS": "Orthokeratosis", "HP_ORTHOKERATOTIC_HYPERKERATOSIS": "Orthokeratotic hyperkeratosis", "HP_ORTHOPNEA": "Orthopnea", "HP_ORTHOSTATIC_HYPOTENSION_DUE_TO_AUTONOMIC_DYSFUNCTION": "Orthostatic hypotension due to autonomic dysfunction", "HP_ORTHOSTATIC_HYPOTENSION": "Orthostatic hypotension", "HP_OSTEOCHONDROMA": "Osteochondroma", "HP_OSTEOCHONDRITIS_DISSECANS": "Osteochondritis dissecans", "HP_OSTEOARTHRITIS_OF_THE_SMALL_JOINTS_OF_THE_HAND": "Osteoarthritis of the small joints of the hand", "HP_OSTEOARTHRITIS": "Osteoarthritis", "HP_OSTEOCHONDROSIS": "Osteochondrosis", "HP_OSTEOLYSIS_INVOLVING_BONES_OF_THE_UPPER_LIMBS": "Osteolysis involving bones of the upper limbs", "HP_OSTEOLYSIS_INVOLVING_BONES_OF_THE_LOWER_LIMBS": "Osteolysis involving bones of the lower limbs", "HP_OSTEOLYSIS": "Osteolysis", "HP_OSTEOLYTIC_DEFECTS_OF_THE_DISTAL_PHALANGES_OF_THE_HAND": "Osteolytic defects of the distal phalanges of the hand", "HP_OSTEOMALACIA": "Osteomalacia", "HP_OSTEOPATHIA_STRIATA": "Osteopathia striata", "HP_OSTEOMYELITIS": "Osteomyelitis", "HP_OSTEOPETROSIS": "Osteopetrosis", "HP_OSTEOSARCOMA": "Osteosarcoma", "HP_OTOSCLEROSIS": "Otosclerosis", "HP_OVAL_FACE": "Oval face", "HP_OVARIAN_CARCINOMA": "Ovarian carcinoma", "HP_OSTEOPENIA": "Osteopenia", "HP_OVARIAN_GONADOBLASTOMA": "Ovarian gonadoblastoma", "HP_OVARIAN_CYST": "Ovarian cyst", "HP_OSTEOPOROSIS": "Osteoporosis", "HP_OVARIAN_PAPILLARY_ADENOCARCINOMA": "Ovarian papillary adenocarcinoma", "HP_OVERFOLDING_OF_THE_SUPERIOR_HELICES": "Overfolding of the superior helices", "HP_OVARIAN_NEOPLASM": "Ovarian neoplasm", "HP_OVERFRIENDLINESS": "Overfriendliness", "HP_OVERHANGING_NASAL_TIP": "Overhanging nasal tip", "HP_OVERGROWTH_OF_EXTERNAL_GENITALIA": "Overgrowth of external genitalia", "HP_OVERGROWTH": "Overgrowth", "HP_OVERRIDING_AORTA": "Overriding aorta", "HP_OVERTUBULATED_LONG_BONES": "Overtubulated long bones", "HP_OVERLAPPING_FINGERS": "Overlapping fingers", "HP_OVERLAPPING_TOE": "Overlapping toe", "HP_OVOID_VERTEBRAL_BODIES": "Ovoid vertebral bodies", "HP_OVOTESTIS": "Ovotestis", "HP_OXYCEPHALY": "Oxycephaly", "HP_OVERWEIGHT": "Overweight", "HP_PAINLESS_FRACTURES_DUE_TO_INJURY": "Painless fractures due to injury", "HP_PAIN_INSENSITIVITY": "Pain insensitivity", "HP_PACE_OF_PROGRESSION": "Pace of progression", "HP_PALATE_FISTULA": "Palate fistula", "HP_PALMAR_HYPERLINEARITY": "Palmar hyperlinearity", "HP_PAIN_IN_HEAD_AND_NECK_REGION": "Pain in head and neck region", "HP_PAIN": "Pain", "HP_PALMAR_HYPERHIDROSIS": "Palmar hyperhidrosis", "HP_PALMAR_PITS": "Palmar pits", "HP_PALLOR": "Pallor", "HP_PALMAR_TELANGIECTASIA": "Palmar telangiectasia", "HP_PALMOPLANTAR_ERYTHEMA": "Palmoplantar erythema", "HP_PALMOPLANTAR_CUTIS_LAXA": "Palmoplantar cutis laxa", "HP_PALMOPLANTAR_BLISTERING": "Palmoplantar blistering", "HP_PALMOPLANTAR_HYPERKERATOSIS": "Palmoplantar hyperkeratosis", "HP_PANCREATIC_APLASIA": "Pancreatic aplasia", "HP_PALPEBRAL_EDEMA": "Palpebral edema", "HP_PANCREATIC_ADENOCARCINOMA": "Pancreatic adenocarcinoma", "HP_PALPITATIONS": "Palpitations", "HP_PANCREATIC_CALCIFICATION": "Pancreatic calcification", "HP_PANCREATIC_ENDOCRINE_TUMOR": "Pancreatic endocrine tumor", "HP_PANCREATIC_FIBROSIS": "Pancreatic fibrosis", "HP_PANCREATIC_HYPOPLASIA": "Pancreatic hypoplasia", "HP_PANCREATIC_CYSTS": "Pancreatic cysts", "HP_PANCREATIC_ISLET_CELL_ADENOMA": "Pancreatic islet cell adenoma", "HP_PANCREATIC_ISLET_CELL_HYPERPLASIA": "Pancreatic islet-cell hyperplasia", "HP_PANCREATIC_PSEUDOCYST": "Pancreatic pseudocyst", "HP_PANCREATITIS": "Pancreatitis", "HP_PANHYPOGAMMAGLOBULINEMIA": "Panhypogammaglobulinemia", "HP_PANCYTOPENIA": "Pancytopenia", "HP_PANHYPOPITUITARISM": "Panhypopituitarism", "HP_PANNICULITIS": "Panniculitis", "HP_PAPILLARY_CYSTADENOMA_OF_THE_EPIDIDYMIS": "Papillary cystadenoma of the epididymis", "HP_PANIC_ATTACK": "Panic attack", "HP_PAPILLARY_RENAL_CELL_CARCINOMA": "Papillary renal cell carcinoma", "HP_PAPILLARY_THYROID_CARCINOMA": "Papillary thyroid carcinoma", "HP_PAPILLEDEMA": "Papilledema", "HP_PARAGANGLIOMA": "Paraganglioma", "HP_PAPILLOMA": "Papilloma", "HP_PARACENTRAL_SCOTOMA": "Paracentral scotoma", "HP_PAPULE": "Papule", "HP_PARADOXICAL_INCREASED_CORTISOL_SECRETION_ON_DEXAMETHASONE_SUPPRESSION_TEST": "", "HP_PARANOIA": "Paranoia", "HP_PARAKERATOSIS": "Parakeratosis", "HP_PARALYSIS": "Paralysis", "HP_PARAPARESIS": "Paraparesis", "HP_PARATHYROID_ADENOMA": "", "HP_PARAPLEGIA": "Paraplegia", "HP_PARATHYROID_CARCINOMA": "Parathyroid carcinoma", "HP_PARATHYROID_HYPERPLASIA": "Parathyroid hyperplasia", "HP_PARAPLEGIA_PARAPARESIS": "Paraplegia/paraparesis", "HP_PARASOMNIA": "Parasomnia", "HP_PARESIS_OF_EXTENSOR_MUSCLES_OF_THE_BIG_TOE": "Paresis of extensor muscles of the big toe", "HP_PARIETAL_BOSSING": "Parietal bossing", "HP_PARIETAL_CORTICAL_ATROPHY": "Parietal cortical atrophy", "HP_PARESTHESIA": "Paresthesia", "HP_PARIETAL_FORAMINA": "Parietal foramina", "HP_PAROXYSMAL_ATRIAL_FIBRILLATION": "Paroxysmal atrial fibrillation", "HP_PARKINSONISM": "Parkinsonism", "HP_PARONYCHIA": "Paronychia", "HP_PARKINSONISM_WITH_FAVORABLE_RESPONSE_TO_DOPAMINERGIC_MEDICATION": "Parkinsonism with favorable response to dopaminergic medication", "HP_PAROXYSMAL_DYSKINESIA": "Paroxysmal dyskinesia", "HP_PAROXYSMAL_DYSTONIA": "Paroxysmal dystonia", "HP_PAROTITIS": "Parotitis", "HP_PAROXYSMAL_INVOLUNTARY_EYE_MOVEMENTS": "Paroxysmal involuntary eye movements", "HP_PAROXYSMAL_BURSTS_OF_LAUGHTER": "Paroxysmal bursts of laughter", "HP_PARTIAL_ABSENCE_OF_SPECIFIC_ANTIBODY_RESPONSE_TO_TETANUS_VACCINE": "Partial absence of specific antibody response to tetanus vaccine", "HP_PAROXYSMAL_VENTRICULAR_TACHYCARDIA": "Paroxysmal ventricular tachycardia", "HP_PAROXYSMAL_SUPRAVENTRICULAR_TACHYCARDIA": "Paroxysmal supraventricular tachycardia", "HP_PARTIAL_ABSENCE_OF_CEREBELLAR_VERMIS": "Partial absence of cerebellar vermis", "HP_PARTIAL_ABSENCE_OF_SPECIFIC_ANTIBODY_RESPONSE_TO_UNCONJUGATED_PNEUMOCOCCUS_VACCINE": "Partial absence of specific antibody response to unconjugated pneumococcus vaccine", "HP_PARTIAL_ALBINISM": "Partial albinism", "HP_PARTIAL_ANOMALOUS_PULMONARY_VENOUS_RETURN": "Partial anomalous pulmonary venous return", "HP_PARTIAL_ABSENCE_OF_THUMB": "Partial absence of thumb", "HP_PARTIAL_AGENESIS_OF_THE_CORPUS_CALLOSUM": "Partial agenesis of the corpus callosum", "HP_PARTIAL_ATRIOVENTRICULAR_CANAL_DEFECT": "Partial atrioventricular canal defect", "HP_PARTIAL_DUPLICATION_OF_THE_DISTAL_PHALANGES_OF_THE_HAND": "Partial duplication of the distal phalanges of the hand", "HP_PARTIAL_DUPLICATION_OF_THE_PHALANX_OF_HAND": "Partial duplication of the phalanx of hand", "HP_PATCHY_ALOPECIA": "Patchy alopecia", "HP_PATCHY_CHANGES_OF_BONE_MINERAL_DENSITY": "Patchy changes of bone mineral density", "HP_PAST_MEDICAL_HISTORY": "Past medical history", "HP_PATCHY_HYPOPIGMENTATION_OF_HAIR": "Patchy hypopigmentation of hair", "HP_PATELLAR_APLASIA": "Patellar aplasia", "HP_PATCHY_PALMOPLANTAR_HYPERKERATOSIS": "Patchy palmoplantar hyperkeratosis", "HP_PATELLAR_HYPOPLASIA": "Patellar hypoplasia", "HP_PATELLAR_SUBLUXATION": "Patellar subluxation", "HP_PATELLAR_DISLOCATION": "Patellar dislocation", "HP_PATENT_DUCTUS_ARTERIOSUS_AFTER_BIRTH_AT_TERM": "Patent ductus arteriosus after birth at term", "HP_PECTORAL_MUSCLE_HYPOPLASIA_APLASIA": "Pectoral muscle hypoplasia/aplasia", "HP_PATENT_FORAMEN_OVALE": "Patent foramen ovale", "HP_PATHOLOGIC_FRACTURE": "Pathologic fracture", "HP_PATENT_DUCTUS_ARTERIOSUS": "Patent ductus arteriosus", "HP_PECTUS_EXCAVATUM_OF_INFERIOR_STERNUM": "Pectus excavatum of inferior sternum", "HP_PECTUS_CARINATUM": "Pectus carinatum", "HP_PEDAL_EDEMA": "Pedal edema", "HP_PECTUS_EXCAVATUM": "Pectus excavatum", "HP_PELVIC_GIRDLE_AMYOTROPHY": "Pelvic girdle amyotrophy", "HP_PEG_SHAPED_MAXILLARY_LATERAL_INCISORS": "Peg-shaped maxillary lateral incisors", "HP_PENETRATING_FOOT_ULCERS": "Penetrating foot ulcers", "HP_PELVIC_KIDNEY": "Pelvic kidney", "HP_PENILE_FRECKLING": "Penile freckling", "HP_PELVIC_GIRDLE_MUSCLE_WEAKNESS": "Pelvic girdle muscle weakness", "HP_PENDULAR_NYSTAGMUS": "Pendular nystagmus", "HP_PENOSCROTAL_HYPOSPADIAS": "Penoscrotal hypospadias", "HP_PEPTIC_ULCER": "Peptic ulcer", "HP_PERCUSSION_MYOTONIA": "Percussion myotonia", "HP_PERIANAL_ABSCESS": "Perianal abscess", "HP_PERIAURICULAR_SKIN_PITS": "Periauricular skin pits", "HP_PERIMEMBRANOUS_VENTRICULAR_SEPTAL_DEFECT": "Perimembranous ventricular septal defect", "HP_PERIFOVEAL_RING_OF_HYPERAUTOFLUORESCENCE": "Perifoveal ring of hyperautofluorescence", "HP_PERICARDITIS": "Pericarditis", "HP_PERINEAL_FISTULA": "Perineal fistula", "HP_PERICARDIAL_EFFUSION": "Pericardial effusion", "HP_PERINEAL_HYPOSPADIAS": "Perineal hypospadias", "HP_PERIODIC_HYPOKALEMIC_PARESIS": "Periodic hypokalemic paresis", "HP_PERINUCLEAR_ANTINEUTROPHIL_ANTIBODY_POSITIVITY": "Perinuclear antineutrophil antibody positivity", "HP_PERIODIC_PARALYSIS": "Periodic paralysis", "HP_PERIODONTITIS": "Periodontitis", "HP_PERIORBITAL_ECCHYMOSIS_WITH_TARSAL_PLATE_SPARING": "", "HP_PERIORBITAL_EDEMA": "Periorbital edema", "HP_PERIORBITAL_WRINKLES": "Periorbital wrinkles", "HP_PERIORBITAL_FULLNESS": "Periorbital fullness", "HP_PERIPHERAL_ARTERIAL_STENOSIS": "Peripheral arterial stenosis", "HP_PERIPAPILLARY_CHORIORETINAL_ATROPHY": "Peripapillary chorioretinal atrophy", "HP_PERIPHERAL_ARTERIOVENOUS_FISTULA": "Peripheral arteriovenous fistula", "HP_PERIPHERAL_AXONAL_NEUROPATHY": "", "HP_PERIPHERAL_CYANOSIS": "Peripheral cyanosis", "HP_PERIPHERAL_AXONAL_DEGENERATION": "Peripheral axonal degeneration", "HP_PERIPHERAL_HYPERMYELINATION": "Peripheral hypermyelination", "HP_PERIPHERAL_DEMYELINATION": "Peripheral demyelination", "HP_PERIPHERAL_HYPOMYELINATION": "Peripheral hypomyelination", "HP_PERIPHERAL_EDEMA": "Peripheral edema", "HP_PERIPHERAL_OPACIFICATION_OF_THE_CORNEA": "Peripheral opacification of the cornea", "HP_PERIPHERAL_NEUROPATHY": "", "HP_PERIPHERAL_PULMONARY_ARTERY_STENOSIS": "Peripheral pulmonary artery stenosis", "HP_PERIPHERAL_RETINAL_AVASCULARIZATION": "", "HP_PERIPHERAL_RETINAL_DEGENERATION": "Peripheral retinal degeneration", "HP_PERIPORTAL_FIBROSIS": "Periportal fibrosis", "HP_PERIPHERAL_VISUAL_FIELD_LOSS": "Peripheral visual field loss", "HP_PERITONEAL_ABSCESS": "Peritoneal abscess", "HP_PERIVENTRICULAR_CYSTS": "Periventricular cysts", "HP_PERISYLVIAN_POLYMICROGYRIA": "Perisylvian polymicrogyria", "HP_PERITONITIS": "Peritonitis", "HP_PERIVENTRICULAR_HETEROTOPIA": "Periventricular heterotopia", "HP_PERIVENTRICULAR_NODULAR_HETEROTOPIA": "Periventricular nodular heterotopia", "HP_PERIVENTRICULAR_WHITE_MATTER_HYPERINTENSITIES": "Periventricular white matter hyperintensities", "HP_PERIVENTRICULAR_LEUKOMALACIA": "Periventricular leukomalacia", "HP_PERMANENT_ATRIAL_FIBRILLATION": "Permanent atrial fibrillation", "HP_PERONEAL_MUSCLE_WEAKNESS": "Peroneal muscle weakness", "HP_PERONEAL_MUSCLE_ATROPHY": "Peroneal muscle atrophy", "HP_PERSISTENCE_OF_PRIMARY_TEETH": "Persistence of primary teeth", "HP_PERSEVERATIVE_THOUGHT": "Perseverative thought", "HP_PERSISTENT_CMV_VIREMIA": "Persistent CMV viremia", "HP_PERSISTENCE_OF_HEMOGLOBIN_F": "Persistence of hemoglobin F", "HP_PERSISTENT_BLEEDING_AFTER_TRAUMA": "Persistent bleeding after trauma", "HP_PERSISTENT_EBV_VIREMIA": "Persistent EBV viremia", "HP_PERSISTENT_HEAD_LAG": "Persistent head lag", "HP_PERSISTENT_OPEN_ANTERIOR_FONTANELLE": "Persistent open anterior fontanelle", "HP_PERSISTENT_PUPILLARY_MEMBRANE": "Persistent pupillary membrane", "HP_PERSONALITY_CHANGES": "Personality changes", "HP_PERSONALITY_DISORDER": "Personality disorder", "HP_PETERS_ANOMALY": "Peters anomaly", "HP_PES_VALGUS": "Pes valgus", "HP_PHALANGEAL_DISLOCATION": "Phalangeal dislocation", "HP_PETECHIAE": "Petechiae", "HP_PHARYNGITIS": "Pharyngitis", "HP_PES_PLANUS": "Pes planus", "HP_PES_CAVUS": "Pes cavus", "HP_PHEOCHROMOCYTOMA": "Pheochromocytoma", "HP_PHIMOSIS": "Phimosis", "HP_PHOCOMELIA": "Phocomelia", "HP_PHONIC_TICS": "Phonic tics", "HP_PHONOPHOBIA": "Phonophobia", "HP_PHOTORECEPTOR_LAYER_LOSS_ON_MACULAR_OCT": "Photoreceptor layer loss on macular OCT", "HP_PHOTOSENSITIVE_MYOCLONIC_SEIZURE": "Photosensitive myoclonic seizure", "HP_PHOTOPSIA": "Photopsia", "HP_PICA": "Pica", "HP_PHOTOPHOBIA": "Photophobia", "HP_PHYSICAL_URTICARIA": "Physical urticaria", "HP_PHOTOSENSITIVE_TONIC_CLONIC_SEIZURE": "Photosensitive tonic-clonic seizure", "HP_PHTHISIS_BULBI": "Phthisis bulbi", "HP_PIERRE_ROBIN_SEQUENCE": "Pierre-Robin sequence", "HP_PILI_CANALICULI": "Pili canaliculi", "HP_PILL_ROLLING_TREMOR": "Pill-rolling tremor", "HP_PILI_TORTI": "Pili torti", "HP_PIGMENTARY_RETINOPATHY": "Pigmentary retinopathy", "HP_PINEAL_CYST": "Pineal cyst", "HP_PITUITARY_GROWTH_HORMONE_CELL_ADENOMA": "Pituitary growth hormone cell adenoma", "HP_PITUITARY_DWARFISM": "Pituitary dwarfism", "HP_PILOMATRIXOMA": "Pilomatrixoma", "HP_PITUITARY_CORTICOTROPIC_CELL_ADENOMA": "Pituitary corticotropic cell adenoma", "HP_PITUITARY_ADENOMA": "Pituitary adenoma", "HP_PLACENTAL_ABRUPTION": "Placental abruption", "HP_PITUITARY_HYPOTHYROIDISM": "Pituitary hypothyroidism", "HP_PITUITARY_PROLACTIN_CELL_ADENOMA": "Pituitary prolactin cell adenoma", "HP_PLATYBASIA": "Platybasia", "HP_PLAGIOCEPHALY": "Plagiocephaly", "HP_PLATYSPONDYLY": "Platyspondyly", "HP_PLETHORA": "Plethora", "HP_PLEURITIS": "Pleuritis", "HP_PNEUMOCYSTIS_JIROVECII_PNEUMONIA": "Pneumocystis jirovecii pneumonia", "HP_PLEURAL_EFFUSION": "Pleural effusion", "HP_PNEUMOTHORAX": "Pneumothorax", "HP_POIKILODERMA": "Poikiloderma", "HP_POIKILOCYTOSIS": "Poikilocytosis", "HP_POINTED_CHIN": "Pointed chin", "HP_POLAR_CATARACT": "Polar cataract", "HP_PNEUMONIA": "Pneumonia", "HP_POLLAKISURIA": "Pollakisuria", "HP_POLYARTICULAR_ARTHROPATHY": "Polyarticular arthropathy", "HP_POLYCLONAL_ELEVATION_OF_IGM": "Polyclonal elevation of IgM", "HP_POLYCYSTIC_KIDNEY_DYSPLASIA": "Polycystic kidney dysplasia", "HP_POLYCYSTIC_LIVER_DISEASE": "Polycystic liver disease", "HP_POLYCYTHEMIA": "Polycythemia", "HP_POLYGENIC_INHERITANCE": "Polygenic inheritance", "HP_POLYDACTYLY": "Polydactyly", "HP_POLYMORPHIC_VENTRICULAR_TACHYCARDIA": "Polymorphic ventricular tachycardia", "HP_POLYMICROGYRIA": "Polymicrogyria", "HP_POLYHYDRAMNIOS": "Polyhydramnios", "HP_POLYNEUROPATHY": "Polyneuropathy", "HP_POLYSPLENIA": "Polysplenia", "HP_POLYPHAGIA": "Polyphagia", "HP_POLYURIA": "Polyuria", "HP_PONTOCEREBELLAR_ATROPHY": "Pontocerebellar atrophy", "HP_POOR_COORDINATION": "", "HP_POOR_APPETITE": "Poor appetite", "HP_POOR_FINE_MOTOR_COORDINATION": "Poor fine motor coordination", "HP_POOR_GROSS_MOTOR_COORDINATION": "Poor gross motor coordination", "HP_POOR_MOTOR_COORDINATION": "", "HP_POPLITEAL_PTERYGIUM": "Popliteal pterygium", "HP_POOR_HEAD_CONTROL": "Poor head control", "HP_POOR_SPEECH": "Poor speech", "HP_POOR_WOUND_HEALING": "Poor wound healing", "HP_POOR_SUCK": "Poor suck", "HP_PORENCEPHALIC_CYST": "Porencephalic cyst", "HP_POROKERATOSIS": "Porokeratosis", "HP_PORPHYRINURIA": "Porphyrinuria", "HP_PORTAL_INFLAMMATION": "Portal inflammation", "HP_PORTAL_FIBROSIS": "Portal fibrosis", "HP_PORTAL_VEIN_THROMBOSIS": "Portal vein thrombosis", "HP_POSITIVE_BLOOD_INFECTIOUS_AGENT_TEST": "", "HP_POSITIVE_ROMBERG_SIGN": "Positive Romberg sign", "HP_POSTAXIAL_FOOT_POLYDACTYLY": "Postaxial foot polydactyly", "HP_POSTAXIAL_HAND_POLYDACTYLY": "Postaxial hand polydactyly", "HP_POSTERIOR_BLEPHARITIS": "Posterior blepharitis", "HP_POSTERIOR_FOSSA_CYST": "Posterior fossa cyst", "HP_POSTAXIAL_POLYDACTYLY": "Postaxial polydactyly", "HP_POSITIONAL_FOOT_DEFORMITY": "Positional foot deformity", "HP_POSTERIOR_EMBRYOTOXON": "Posterior embryotoxon", "HP_POSTERIOR_HELIX_PIT": "Posterior helix pit", "HP_POSTERIOR_PHARYNGEAL_CLEFT": "", "HP_POSTERIORLY_ROTATED_EARS": "Posteriorly rotated ears", "HP_POSTERIOR_PITUITARY_DYSGENESIS": "Posterior pituitary dysgenesis", "HP_POSTERIOR_PLAGIOCEPHALY": "Posterior plagiocephaly", "HP_POSTERIOR_POLAR_CATARACT": "Posterior polar cataract", "HP_POSTERIOR_RIB_CUPPING": "Posterior rib cupping", "HP_POSTERIOR_STAPHYLOMA": "Posterior staphyloma", "HP_POSTERIOR_SYNECHIAE_OF_THE_ANTERIOR_CHAMBER": "Posterior synechiae of the anterior chamber", "HP_POSTEXERTIONAL_SYMPTOM_EXACERBATION": "Postexertional symptom exacerbation", "HP_POSTERIOR_UVEITIS": "Posterior uveitis", "HP_POSTNATAL_MACROCEPHALY": "Postnatal macrocephaly", "HP_POSTPRANDIAL_HYPERGLYCEMIA": "Postprandial hyperglycemia", "HP_POSTNATAL_GROWTH_RETARDATION": "Postnatal growth retardation", "HP_POSTURAL_TREMOR": "Postural tremor", "HP_POSTTERM_PREGNANCY": "Postterm pregnancy", "HP_POSTURAL_INSTABILITY": "Postural instability", "HP_POST_PARTUM_HEMORRHAGE": "Post-partum hemorrhage", "HP_PREAXIAL_FOOT_POLYDACTYLY": "Preaxial foot polydactyly", "HP_PREAURICULAR_SKIN_TAG": "Preauricular skin tag", "HP_PREAXIAL_HAND_POLYDACTYLY": "Preaxial hand polydactyly", "HP_PRECOCIOUS_ATHEROSCLEROSIS": "Precocious atherosclerosis", "HP_PREAXIAL_POLYDACTYLY": "Preaxial polydactyly", "HP_PRECOCIOUS_PUBERTY_IN_FEMALES": "Precocious puberty in females", "HP_PREDOMINANTLY_LOWER_LIMB_LYMPHEDEMA": "Predominantly lower limb lymphedema", "HP_PRELINGUAL_SENSORINEURAL_HEARING_IMPAIRMENT": "Prelingual sensorineural hearing impairment", "HP_PREMATURE_ADRENARCHE": "Premature adrenarche", "HP_PREGNANCY_EXPOSURE": "Pregnancy exposure", "HP_PREMATURE_ATRIAL_CONTRACTIONS": "Premature atrial contractions", "HP_PREMATURE_ARTERIOSCLEROSIS": "Premature arteriosclerosis", "HP_PREMATURE_CORONARY_ARTERY_ATHEROSCLEROSIS": "Premature coronary artery atherosclerosis", "HP_PREMATURELY_AGED_APPEARANCE": "Prematurely aged appearance", "HP_PREMATURE_LOSS_OF_PERMANENT_TEETH": "Premature loss of permanent teeth", "HP_PREMATURE_BIRTH": "Premature birth", "HP_PREMATURE_GRAYING_OF_HAIR": "Premature graying of hair", "HP_PREMATURE_LOSS_OF_PRIMARY_TEETH": "Premature loss of primary teeth", "HP_PREMATURE_OSTEOARTHRITIS": "Premature osteoarthritis", "HP_PREMATURE_LOSS_OF_TEETH": "Premature loss of teeth", "HP_PREMATURE_PUBARCHE": "Premature pubarche", "HP_PREMATURE_RUPTURE_OF_MEMBRANES": "Premature rupture of membranes", "HP_PREMATURE_OVARIAN_INSUFFICIENCY": "Premature ovarian insufficiency", "HP_PREMATURE_THELARCHE": "Premature thelarche", "HP_PREMATURE_VENTRICULAR_CONTRACTION": "Premature ventricular contraction", "HP_PRIMARY_ADRENAL_INSUFFICIENCY": "Primary adrenal insufficiency", "HP_PRENATAL_DEATH": "Prenatal death", "HP_PREMATURE_SKIN_WRINKLING": "Premature skin wrinkling", "HP_PRIMARY_CONGENITAL_GLAUCOMA": "Primary congenital glaucoma", "HP_PRENATAL_MOVEMENT_ABNORMALITY": "Prenatal movement abnormality", "HP_PRIMARY_AMENORRHEA": "Primary amenorrhea", "HP_PRIMARY_HYPERALDOSTERONISM": "Primary hyperaldosteronism", "HP_PRIMARY_GONADAL_INSUFFICIENCY": "Primary gonadal insufficiency", "HP_PRIMARY_HYPERPARATHYROIDISM": "Primary hyperparathyroidism", "HP_PRIMARY_HYPERCORTISOLISM": "Primary hypercortisolism", "HP_PRIMARY_HYPOTHYROIDISM": "Primary hypothyroidism", "HP_PRIMARY_MICROCEPHALY": "Primary microcephaly", "HP_PRIMARY_PERITONEAL_CARCINOMA": "Primary peritoneal carcinoma", "HP_PROBOSCIS": "Proboscis", "HP_PRIMITIVE_NEUROECTODERMAL_TUMOR": "Primitive neuroectodermal tumor", "HP_PRIMITIVE_REFLEX": "Primitive reflex", "HP_PROFOUND_GLOBAL_DEVELOPMENTAL_DELAY": "Profound global developmental delay", "HP_PRODUCTIVE_COUGH": "Productive cough", "HP_PROFOUND_HEARING_IMPAIRMENT": "Profound hearing impairment", "HP_PROGEROID_FACIAL_APPEARANCE": "Progeroid facial appearance", "HP_PROFOUND_SENSORINEURAL_HEARING_IMPAIRMENT": "Profound sensorineural hearing impairment", "HP_PROGRESSIVE_DISTAL_MUSCLE_WEAKNESS": "Progressive distal muscle weakness", "HP_PROGRESSIVE_CEREBELLAR_ATAXIA": "Progressive cerebellar ataxia", "HP_PROGRESSIVE_ENCEPHALOPATHY": "Progressive encephalopathy", "HP_PROGRESSIVE_EXTRAPYRAMIDAL_MOVEMENT_DISORDER": "Progressive extrapyramidal movement disorder", "HP_PROGRESSIVE_EXTERNAL_OPHTHALMOPLEGIA": "Progressive external ophthalmoplegia", "HP_PROGRESSIVE_DISTAL_MUSCULAR_ATROPHY": "Progressive distal muscular atrophy", "HP_PROGRESSIVE_FLEXION_CONTRACTURES": "Progressive flexion contractures", "HP_PROGRESSIVE_GAIT_ATAXIA": "Progressive gait ataxia", "HP_PROGRESSIVE_HEARING_IMPAIRMENT": "Progressive hearing impairment", "HP_PROGRESSIVE_LANGUAGE_DETERIORATION": "", "HP_PROGRESSIVE_LEUKOENCEPHALOPATHY": "Progressive leukoencephalopathy", "HP_PROGRESSIVE_MACROCEPHALY": "Progressive macrocephaly", "HP_PROGRESSIVE_MICROCEPHALY": "Progressive microcephaly", "HP_PROGRESSIVE_MUSCLE_WEAKNESS": "Progressive muscle weakness", "HP_PROGRESSIVE_NIGHT_BLINDNESS": "", "HP_PROGRESSIVE_PERIPHERAL_NEUROPATHY": "Progressive peripheral neuropathy", "HP_PROGRESSIVE_PROXIMAL_MUSCLE_WEAKNESS": "Progressive proximal muscle weakness", "HP_PROGRESSIVE_NEUROLOGIC_DETERIORATION": "Progressive neurologic deterioration", "HP_PROGRESSIVE_PTOSIS": "Progressive ptosis", "HP_PROGRESSIVE_PSYCHOMOTOR_DETERIORATION": "Progressive psychomotor deterioration", "HP_PROGRESSIVE_PULMONARY_FUNCTION_IMPAIRMENT": "Progressive pulmonary function impairment", "HP_PROGRESSIVE_SPASTICITY": "Progressive spasticity", "HP_PROGRESSIVE_SPASTIC_PARAPARESIS": "Progressive spastic paraparesis", "HP_PROGRESSIVE_SPASTIC_QUADRIPLEGIA": "Progressive spastic quadriplegia", "HP_PROGRESSIVE_SPASTIC_PARAPLEGIA": "Progressive spastic paraplegia", "HP_PROGRESSIVE_VISUAL_FIELD_DEFECTS": "Progressive visual field defects", "HP_PROGRESSIVE_VISUAL_LOSS": "Progressive visual loss", "HP_PROLINURIA": "Prolinuria", "HP_PROLONGED_BLEEDING_FOLLOWING_CIRCUMCISION": "Prolonged bleeding following circumcision", "HP_PROLONGED_BLEEDING_AFTER_DENTAL_EXTRACTION": "Prolonged bleeding after dental extraction", "HP_PROLONGED_BLEEDING_AFTER_SURGERY": "Prolonged bleeding after surgery", "HP_PROLONGED_BLEEDING_TIME": "Prolonged bleeding time", "HP_PROLONGED_BLEEDING_FOLLOWING_PROCEDURE": "Prolonged bleeding following procedure", "HP_PROLONGED_PARTIAL_THROMBOPLASTIN_TIME": "Prolonged partial thromboplastin time", "HP_PROLONGED_QRS_COMPLEX": "Prolonged QRS complex", "HP_PROLONGED_PR_INTERVAL": "Prolonged PR interval", "HP_PROLONGED_QTC_INTERVAL": "Prolonged QTc interval", "HP_PROLONGED_NEONATAL_JAUNDICE": "Prolonged neonatal jaundice", "HP_PROLONGED_QT_INTERVAL": "", "HP_PROMINENCE_OF_THE_PREMAXILLA": "Prominence of the premaxilla", "HP_PROMINENT_ANTIHELIX": "Prominent antihelix", "HP_PROMINENT_ANTITRAGUS": "Prominent antitragus", "HP_PROMINENT_CALCANEUS": "Prominent calcaneus", "HP_PROMINENT_COCCYX": "Prominent coccyx", "HP_PROMINENT_CRUS_OF_HELIX": "Prominent crus of helix", "HP_PROMINENT_EAR_HELIX": "Prominent ear helix", "HP_PROMINENT_DIGIT_PAD": "Prominent digit pad", "HP_PROMINENT_EYELASHES": "Prominent eyelashes", "HP_PROMINENT_INTERPHALANGEAL_JOINTS": "Prominent interphalangeal joints", "HP_PROMINENT_METOPIC_RIDGE": "Prominent metopic ridge", "HP_PROMINENT_FOREHEAD": "Prominent forehead", "HP_PROMINENT_NASAL_TIP": "Prominent nasal tip", "HP_PROMINENT_NASAL_BRIDGE": "Prominent nasal bridge", "HP_PROMINENT_OCCIPUT": "Prominent occiput", "HP_PROMINENT_SUPERFICIAL_BLOOD_VESSELS": "Prominent superficial blood vessels", "HP_PROMINENT_NOSE": "Prominent nose", "HP_PROMINENT_STERNUM": "Prominent sternum", "HP_PROMINENT_UMBILICUS": "Prominent umbilicus", "HP_PROMINENT_SUPRAORBITAL_RIDGES": "Prominent supraorbital ridges", "HP_PROMINENT_VEINS_ON_TRUNK": "Prominent veins on trunk", "HP_PROPORTIONATE_TALL_STATURE": "Proportionate tall stature", "HP_PROPORTIONATE_SHORT_STATURE": "Proportionate short stature", "HP_PROSTATE_CANCER": "Prostate cancer", "HP_PROTEIN_AVOIDANCE": "Protein avoidance", "HP_PROPTOSIS": "Proptosis", "HP_PROSTATITIS": "Prostatitis", "HP_PROTEIN_LOSING_ENTEROPATHY": "Protein-losing enteropathy", "HP_PROTRACTED_DIARRHEA": "Protracted diarrhea", "HP_PROTRUSIO_ACETABULI": "Protrusio acetabuli", "HP_PROTRUDING_EAR": "Protruding ear", "HP_PROTRUDING_TONGUE": "Protruding tongue", "HP_PROTUBERANT_ABDOMEN": "Protuberant abdomen", "HP_PROXIMAL_AMYOTROPHY": "Proximal amyotrophy", "HP_PROXIMAL_FEMORAL_EPIPHYSIOLYSIS": "Proximal femoral epiphysiolysis", "HP_PROXIMAL_HYPERREFLEXIA": "Proximal hyperreflexia", "HP_PROXIMAL_MUSCLE_WEAKNESS_IN_LOWER_LIMBS": "", "HP_PROXIMAL_MUSCLE_WEAKNESS_IN_UPPER_LIMBS": "", "HP_PROXIMAL_PLACEMENT_OF_THUMB": "Proximal placement of thumb", "HP_PROXIMAL_RENAL_TUBULAR_ACIDOSIS": "Proximal renal tubular acidosis", "HP_PROXIMAL_RADIO_ULNAR_SYNOSTOSIS": "Proximal radio-ulnar synostosis", "HP_PROXIMAL_MUSCLE_WEAKNESS": "Proximal muscle weakness", "HP_PROXIMAL_SYMPHALANGISM_OF_HANDS": "Proximal symphalangism of hands", "HP_PRURITIS_ON_HAND": "Pruritis on hand", "HP_PROXIMAL_TUBULOPATHY": "Proximal tubulopathy", "HP_PSEUDOARTHROSIS": "Pseudoarthrosis", "HP_PSEUDOBULBAR_PARALYSIS": "Pseudobulbar paralysis", "HP_PRURITUS": "Pruritus", "HP_PSEUDOEPIPHYSES": "Pseudoepiphyses", "HP_PSEUDOEPIPHYSES_OF_HAND_BONES": "Pseudoepiphyses of hand bones", "HP_PSEUDOBULBAR_SIGNS": "Pseudobulbar signs", "HP_PSEUDOEPIPHYSES_OF_THE_METACARPALS": "", "HP_PSEUDOEPIPHYSES_OF_THE_PHALANGES_OF_THE_HAND": "Pseudoepiphyses of the phalanges of the hand", "HP_PSEUDOHYPOALDOSTERONISM": "Pseudohypoaldosteronism", "HP_PSORIASIFORM_DERMATITIS": "Psoriasiform dermatitis", "HP_PSYCHIC_EPILEPTIC_AURA": "Psychic epileptic aura", "HP_PSORIASIFORM_LESION": "Psoriasiform lesion", "HP_PSYCHOMOTOR_DETERIORATION": "Psychomotor deterioration", "HP_PSYCHOSIS": "", "HP_PSYCHOTIC_MENTATION": "Psychotic mentation", "HP_PSYCHOTIC_EPISODES": "Psychotic episodes", "HP_PTERYGIUM": "Pterygium", "HP_PULMONARY_ARTERIAL_HYPERTENSION": "", "HP_PULMONARY_ARTERIOVENOUS_MALFORMATION": "Pulmonary arteriovenous malformation", "HP_PULMONARY_ARTERY_ANEURYSM": "Pulmonary artery aneurysm", "HP_PULMONARY_ARTERY_DILATATION": "Pulmonary artery dilatation", "HP_PTOSIS": "Ptosis", "HP_PULMONARY_ARTERY_HYPOPLASIA": "Pulmonary artery hypoplasia", "HP_PULMONARY_ARTERY_ATRESIA": "Pulmonary artery atresia", "HP_PUBERTY_AND_GONADAL_DISORDERS": "Puberty and gonadal disorders", "HP_PULMONARY_ARTERY_STENOSIS": "Pulmonary artery stenosis", "HP_PULMONARY_CARCINOID_TUMOR": "Pulmonary carcinoid tumor", "HP_PULMONARY_CYST": "Pulmonary cyst", "HP_PULMONARY_EDEMA": "Pulmonary edema", "HP_PULMONARY_EMBOLISM": "Pulmonary embolism", "HP_PULMONARY_HEMORRHAGE": "Pulmonary hemorrhage", "HP_PULMONARY_FIBROSIS": "Pulmonary fibrosis", "HP_PULMONARY_INFILTRATES": "Pulmonary infiltrates", "HP_PULMONARY_INTERSTITIAL_HIGH_RESOLUTION_COMPUTED_TOMOGRAPHY_ABNORMALITY": "Pulmonary interstitial high-resolution computed tomography abnormality", "HP_PULMONARY_HYPOPLASIA": "Pulmonary hypoplasia", "HP_PULMONARY_INSUFFICIENCY": "", "HP_PULMONARY_INTERSTITIAL_THICKENING": "Pulmonary interstitial thickening", "HP_PULMONARY_LYMPHANGIECTASIA": "Pulmonary lymphangiectasia", "HP_PULMONARY_OPACITY": "Pulmonary opacity", "HP_PULMONARY_VENOUS_HYPERTENSION": "Pulmonary venous hypertension", "HP_PULP_CALCIFICATION": "Pulp calcification", "HP_PULVERULENT_CATARACT": "Pulverulent cataract", "HP_PUNCTATE_CATARACT": "Punctate cataract", "HP_PULMONIC_STENOSIS": "Pulmonic stenosis", "HP_PUNDING": "Punding", "HP_PUNCTATE_OPACIFICATION_OF_THE_CORNEA": "Punctate opacification of the cornea", "HP_PUNCTATE_KERATITIS": "Punctate keratitis", "HP_PUNCTATE_PALMOPLANTAR_HYPERKERATOSIS": "Punctate palmoplantar hyperkeratosis", "HP_PURE_RED_CELL_APLASIA": "Pure red cell aplasia", "HP_PURPURA": "Purpura", "HP_PURSED_LIPS": "Pursed lips", "HP_PUSTULE": "Pustule", "HP_PYELONEPHRITIS": "Pyelonephritis", "HP_PYODERMA": "Pyoderma", "HP_PYODERMA_GANGRENOSUM": "Pyoderma gangrenosum", "HP_QUADRICEPS_MUSCLE_WEAKNESS": "Quadriceps muscle weakness", "HP_RACHITIC_ROSARY": "Rachitic rosary", "HP_PYRIDOXINE_RESPONSIVE_SIDEROBLASTIC_ANEMIA": "", "HP_QUADRICEPS_MUSCLE_ATROPHY": "Quadriceps muscle atrophy", "HP_RADIAL_DEVIATION_OF_FINGER": "", "HP_RADIAL_DEVIATION_OF_THE_2ND_FINGER": "Radial deviation of the 2nd finger", "HP_RADIAL_DEVIATION_OF_THE_HAND": "Radial deviation of the hand", "HP_RADIAL_DEVIATION_OF_THE_HAND_OR_OF_FINGERS_OF_THE_HAND": "Radial deviation of the hand or of fingers of the hand", "HP_RADIAL_HEAD_SUBLUXATION": "Radial head subluxation", "HP_RAGGED_RED_MUSCLE_FIBERS": "Ragged-red muscle fibers", "HP_RADIOULNAR_SYNOSTOSIS": "Radioulnar synostosis", "HP_RAPIDLY_PROGRESSIVE": "Rapidly progressive", "HP_REACTIVE_HYPOGLYCEMIA": "Reactive hypoglycemia", "HP_RAYNAUD_PHENOMENON": "Raynaud phenomenon", "HP_RECEPTIVE_LANGUAGE_DELAY": "Receptive language delay", "HP_RECTAL_ABSCESS": "Rectal abscess", "HP_RECTAL_FISTULA": "Rectal fistula", "HP_RECTAL_POLYPOSIS": "Rectal polyposis", "HP_RECURRENT_ABSCESS_FORMATION": "Recurrent abscess formation", "HP_RECTAL_PROLAPSE": "Rectal prolapse", "HP_RECTOVAGINAL_FISTULA": "Rectovaginal fistula", "HP_RECURRENT_ACUTE_RESPIRATORY_TRACT_INFECTION": "Recurrent acute respiratory tract infection", "HP_RECURRENT_APHTHOUS_STOMATITIS": "Recurrent aphthous stomatitis", "HP_RECURRENT_ASPIRATION_PNEUMONIA": "Recurrent aspiration pneumonia", "HP_RECURRENT_ASPERGILLUS_INFECTIONS": "Recurrent Aspergillus infections", "HP_RECURRENT_BACTERIAL_SKIN_INFECTIONS": "Recurrent bacterial skin infections", "HP_RECURRENT_BACTERIAL_INFECTIONS": "Recurrent bacterial infections", "HP_RECURRENT_CANDIDA_INFECTIONS": "Recurrent candida infections", "HP_RECURRENT_BRONCHOPULMONARY_INFECTIONS": "Recurrent bronchopulmonary infections", "HP_RECURRENT_CORNEAL_EROSIONS": "Recurrent corneal erosions", "HP_RECURRENT_BRONCHITIS": "Recurrent bronchitis", "HP_RECURRENT_CUTANEOUS_ABSCESS_FORMATION": "Recurrent cutaneous abscess formation", "HP_RECURRENT_ENTEROVIRAL_INFECTIONS": "Recurrent enteroviral infections", "HP_RECURRENT_CUTANEOUS_FUNGAL_INFECTIONS": "Recurrent cutaneous fungal infections", "HP_RECURRENT_EAR_INFECTIONS": "Recurrent ear infections", "HP_RECURRENT_FEVER": "Recurrent fever", "HP_RECURRENT_FRACTURES": "Recurrent fractures", "HP_RECURRENT_HAND_FLAPPING": "Recurrent hand flapping", "HP_RECURRENT_GASTROENTERITIS": "Recurrent gastroenteritis", "HP_RECURRENT_HAEMOPHILUS_INFLUENZAE_INFECTIONS": "Recurrent Haemophilus influenzae infections", "HP_RECURRENT_GRAM_NEGATIVE_BACTERIAL_INFECTIONS": "Recurrent gram-negative bacterial infections", "HP_RECURRENT_HYPOGLYCEMIA": "Recurrent hypoglycemia", "HP_RECURRENT_JOINT_DISLOCATION": "Recurrent joint dislocation", "HP_RECURRENT_INTRAPULMONARY_HEMORRHAGE": "Recurrent intrapulmonary hemorrhage", "HP_RECURRENT_INFECTION_OF_THE_GASTROINTESTINAL_TRACT": "Recurrent infection of the gastrointestinal tract", "HP_RECURRENT_KLEBSIELLA_INFECTIONS": "Recurrent Klebsiella infections", "HP_RECURRENT_MENINGITIS": "Recurrent meningitis", "HP_RECURRENT_MYOGLOBINURIA": "Recurrent myoglobinuria", "HP_RECURRENT_NEISSERIAL_INFECTIONS": "Recurrent Neisserial infections", "HP_RECURRENT_MYCOBACTERIAL_INFECTIONS": "Recurrent mycobacterial infections", "HP_RECURRENT_LOWER_RESPIRATORY_TRACT_INFECTIONS": "Recurrent lower respiratory tract infections", "HP_RECURRENT_OPPORTUNISTIC_INFECTIONS": "Recurrent opportunistic infections", "HP_RECURRENT_PANCREATITIS": "Recurrent pancreatitis", "HP_RECURRENT_PAROXYSMAL_HEADACHE": "Recurrent paroxysmal headache", "HP_RECURRENT_PATELLAR_DISLOCATION": "Recurrent patellar dislocation", "HP_RECURRENT_OTITIS_MEDIA": "Recurrent otitis media", "HP_RECURRENT_PHARYNGITIS": "Recurrent pharyngitis", "HP_RECURRENT_MALADAPTIVE_BEHAVIOR": "Recurrent maladaptive behavior", "HP_RECURRENT_PNEUMONIA": "Recurrent pneumonia", "HP_RECURRENT_SINUSITIS": "Recurrent sinusitis", "HP_RECURRENT_SINOPULMONARY_INFECTIONS": "Recurrent sinopulmonary infections", "HP_RECURRENT_PROTOZOAN_INFECTIONS": "Recurrent protozoan infections", "HP_RECURRENT_SPONTANEOUS_ABORTION": "Recurrent spontaneous abortion", "HP_RECURRENT_STREPTOCOCCAL_INFECTIONS": "Recurrent streptococcal infections", "HP_RECURRENT_SKIN_INFECTIONS": "Recurrent skin infections", "HP_RECURRENT_STAPHYLOCOCCAL_INFECTIONS": "Recurrent staphylococcal infections", "HP_RECURRENT_THROMBOPHLEBITIS": "Recurrent thrombophlebitis", "HP_RECURRENT_SYSTEMIC_PYOGENIC_INFECTIONS": "Recurrent systemic pyogenic infections", "HP_RECURRENT_RESPIRATORY_INFECTIONS": "Recurrent respiratory infections", "HP_RECURRENT_UPPER_AND_LOWER_RESPIRATORY_TRACT_INFECTIONS": "Recurrent upper and lower respiratory tract infections", "HP_RECURRENT_TONSILLITIS": "Recurrent tonsillitis", "HP_REDUCED_AMPLITUDE_OF_DARK_ADAPTED_BRIGHT_FLASH_ELECTRORETINOGRAM_A_WAVE": "", "HP_RECURRENT_VIRAL_INFECTIONS": "Recurrent viral infections", "HP_REDUCED_ANTIGEN_SPECIFIC_T_CELL_PROLIFERATION": "Reduced antigen-specific T cell proliferation", "HP_REDUCED_BLOOD_FOLATE_CONCENTRATION": "Reduced blood folate concentration", "HP_REDUCED_BRAIN_N_ACETYL_ASPARTATE_LEVEL_BY_MRS": "Reduced brain N-acetyl aspartate level by MRS", "HP_REDUCED_CIRCULATING_CH50_ACTIVITY": "Reduced circulating CH50 activity", "HP_RECURRENT_URINARY_TRACT_INFECTIONS": "Recurrent urinary tract infections", "HP_REDUCED_CIRCULATING_GROWTH_HORMONE_CONCENTRATION": "Reduced circulating growth hormone concentration", "HP_REDUCED_CEREBRAL_WHITE_MATTER_VOLUME": "Reduced cerebral white matter volume", "HP_REDUCED_ATTENTION_REGULATION": "Reduced attention regulation", "HP_REDUCED_CIRCULATING_PROLACTIN_CONCENTRATION": "Reduced circulating prolactin concentration", "HP_REDUCED_C_PEPTIDE_LEVEL": "Reduced C-peptide level", "HP_REDUCED_DELAYED_HYPERSENSITIVITY": "Reduced delayed hypersensitivity", "HP_REDUCED_FACTOR_VII_ACTIVITY": "Reduced factor VII activity", "HP_REDUCED_FACTOR_XIII_ACTIVITY": "Reduced factor XIII activity", "HP_REDUCED_CONSCIOUSNESS": "Reduced consciousness", "HP_REDUCED_FACTOR_XI_ACTIVITY": "Reduced factor XI activity", "HP_REDUCED_FORCED_EXPIRATORY_VOLUME_IN_ONE_SECOND": "Reduced forced expiratory volume in one second", "HP_REDUCED_FEV1_FVC_RATIO": "Reduced FEV1/FVC ratio", "HP_REDUCED_FACTOR_XII_ACTIVITY": "Reduced factor XII activity", "HP_REDUCED_FORCED_VITAL_CAPACITY": "Reduced forced vital capacity", "HP_REDUCED_MUSCLE_FIBER_ALPHA_DYSTROGLYCAN": "", "HP_REDUCED_LEFT_VENTRICULAR_EJECTION_FRACTION": "Reduced left ventricular ejection fraction", "HP_REDUCED_NATURAL_KILLER_CELL_ACTIVITY": "", "HP_REDUCED_NUMBER_OF_CORNEAL_ENDOTHELIAL_CELLS": "Reduced number of corneal endothelial cells", "HP_REDUCED_NATURAL_KILLER_CELL_COUNT": "", "HP_REDUCED_NUMBER_OF_INTRAHEPATIC_BILE_DUCTS": "Reduced number of intrahepatic bile ducts", "HP_REDUCED_PANCREATIC_BETA_CELLS": "Reduced pancreatic beta cells", "HP_REDUCED_PROTEIN_C_ACTIVITY": "Reduced protein C activity", "HP_REDUCED_PROGRESSIVE_SPERM_MOTILITY": "Reduced progressive sperm motility", "HP_REDUCED_SOCIAL_RECIPROCITY": "", "HP_REDUCED_RENAL_CORTICOMEDULLARY_DIFFERENTIATION": "Reduced renal corticomedullary differentiation", "HP_REDUCED_PROTEIN_S_ACTIVITY": "Reduced protein S activity", "HP_REDUCED_SPERM_MOTILITY": "Reduced sperm motility", "HP_REDUCED_SUBCUTANEOUS_ADIPOSE_TISSUE": "Reduced subcutaneous adipose tissue", "HP_REDUCED_SYSTOLIC_FUNCTION": "Reduced systolic function", "HP_REDUNDANT_NECK_SKIN": "Redundant neck skin", "HP_REDUCED_VITAL_CAPACITY": "Reduced vital capacity", "HP_RED_GREEN_DYSCHROMATOPSIA": "Red-green dyschromatopsia", "HP_RED_HAIR": "Red hair", "HP_REFLEX_SEIZURE": "Reflex seizure", "HP_REDUNDANT_SKIN": "Redundant skin", "HP_REDUCED_TENDON_REFLEXES": "Reduced tendon reflexes", "HP_RED_EYE": "Red eye", "HP_REDUCED_VISUAL_ACUITY": "Reduced visual acuity", "HP_REFRACTORY_ANEMIA": "Refractory anemia", "HP_RELATIVE_MACROCEPHALY": "Relative macrocephaly", "HP_REMNANTS_OF_THE_HYALOID_VASCULAR_SYSTEM": "Remnants of the hyaloid vascular system", "HP_RENAL_ANGIOMYOLIPOMA": "Renal angiomyolipoma", "HP_REGIONAL_ABNORMALITY_OF_SKIN": "Regional abnormality of skin", "HP_RENAL_AMYLOIDOSIS": "Renal amyloidosis", "HP_RENAL_ATROPHY": "Renal atrophy", "HP_RENAL_ARTERY_STENOSIS": "", "HP_RENAL_CORTICAL_CYSTS": "Renal cortical cysts", "HP_RENAL_CORTICAL_MICROCYSTS": "Renal cortical microcysts", "HP_RENAL_CORTICOMEDULLARY_CYSTS": "Renal corticomedullary cysts", "HP_RENAL_AGENESIS": "Renal agenesis", "HP_RENAL_CELL_CARCINOMA": "Renal cell carcinoma", "HP_RENAL_DUPLICATION": "", "HP_RENAL_FANCONI_SYNDROME": "Renal Fanconi syndrome", "HP_RENAL_DYSPLASIA": "Renal dysplasia", "HP_RENAL_CYST": "Renal cyst", "HP_RENAL_FIBROSIS": "Renal fibrosis", "HP_RENAL_HAMARTOMA": "Renal hamartoma", "HP_RENAL_INTERSTITIAL_FIBROSIS": "Renal interstitial fibrosis", "HP_RENAL_HYPOPLASIA": "Renal hypoplasia", "HP_RENAL_MAGNESIUM_WASTING": "Renal magnesium wasting", "HP_RENAL_MALROTATION": "Renal malrotation", "HP_RENAL_NECROSIS": "", "HP_RENAL_PHOSPHATE_WASTING": "Renal phosphate wasting", "HP_RENAL_HYPOPLASIA_APLASIA": "Renal hypoplasia/aplasia", "HP_RENAL_POTASSIUM_WASTING": "Renal potassium wasting", "HP_RENAL_SALT_WASTING": "Renal salt wasting", "HP_RENAL_INSUFFICIENCY": "Renal insufficiency", "HP_RENAL_STEATOSIS": "Renal steatosis", "HP_RENAL_SODIUM_WASTING": "Renal sodium wasting", "HP_RENAL_TUBULAR_ATROPHY": "Renal tubular atrophy", "HP_RENAL_TUBULAR_ACIDOSIS": "Renal tubular acidosis", "HP_RENOVASCULAR_HYPERTENSION": "Renovascular hypertension", "HP_RESPIRATORY_ALKALOSIS": "Respiratory alkalosis", "HP_RENAL_TUBULAR_DYSFUNCTION": "Renal tubular dysfunction", "HP_REPETITIVE_COMPULSIVE_BEHAVIOR": "Repetitive compulsive behavior", "HP_RESPIRATORY_ARREST": "Respiratory arrest", "HP_RESPIRATORY_DISTRESS": "Respiratory distress", "HP_RESPIRATORY_FAILURE_REQUIRING_ASSISTED_VENTILATION": "Respiratory failure requiring assisted ventilation", "HP_RESPIRATORY_INSUFFICIENCY_DUE_TO_DEFECTIVE_CILIARY_CLEARANCE": "Respiratory insufficiency due to defective ciliary clearance", "HP_RESPIRATORY_PARALYSIS": "Respiratory paralysis", "HP_RESPIRATORY_FAILURE": "Respiratory failure", "HP_RESPONSE_TO_DRUGS_ACTING_ON_NEUROMUSCULAR_TRANSMISSION": "Response to drugs acting on neuromuscular transmission", "HP_RESTING_TREMOR": "Resting tremor", "HP_RESTLESSNESS": "Restlessness", "HP_RESPIRATORY_INSUFFICIENCY": "Respiratory insufficiency", "HP_RESTLESS_LEGS": "", "HP_RESTRICTIVE_CARDIOMYOPATHY": "Restrictive cardiomyopathy", "HP_RESTRICTIVE_BEHAVIOR": "Restrictive behavior", "HP_RESPIRATORY_TRACT_INFECTION": "Respiratory tract infection", "HP_RETICULAR_HYPERPIGMENTATION": "Reticular hyperpigmentation", "HP_RETICULATED_SKIN_PIGMENTATION": "Reticulated skin pigmentation", "HP_RESTRICTIVE_VENTILATORY_DEFECT": "Restrictive ventilatory defect", "HP_RETINAL_ARTERIAL_TORTUOSITY": "Retinal arterial tortuosity", "HP_RETICULOCYTOPENIA": "Reticulocytopenia", "HP_RETICULOCYTOSIS": "Reticulocytosis", "HP_RETINAL_ARTERIOLAR_TORTUOSITY": "Retinal arteriolar tortuosity", "HP_RETINAL_COLOBOMA": "Retinal coloboma", "HP_RETINAL_DYSPLASIA": "Retinal dysplasia", "HP_RETINAL_ATROPHY": "Retinal atrophy", "HP_RETINAL_DETACHMENT": "Retinal detachment", "HP_RETINAL_DEGENERATION": "Retinal degeneration", "HP_RETINAL_EXUDATE": "Retinal exudate", "HP_RETINAL_DYSTROPHY": "Retinal dystrophy", "HP_RETINAL_FOLD": "Retinal fold", "HP_RETINAL_FLECKS": "Retinal flecks", "HP_RETINAL_HAMARTOMA": "Retinal hamartoma", "HP_RETINAL_HEMORRHAGE": "", "HP_RETINAL_HOLE": "Retinal hole", "HP_RETINAL_NEOVASCULARIZATION": "Retinal neovascularization", "HP_RETINAL_NONATTACHMENT": "Retinal nonattachment", "HP_RETINAL_PERFORATION": "Retinal perforation", "HP_RETINAL_PIGMENT_EPITHELIAL_ATROPHY": "Retinal pigment epithelial atrophy", "HP_RETINAL_TELANGIECTASIA": "Retinal telangiectasia", "HP_RETINAL_THINNING": "", "HP_RETINAL_VEIN_OCCLUSION": "", "HP_RETINAL_PIGMENT_EPITHELIAL_MOTTLING": "Retinal pigment epithelial mottling", "HP_RETINAL_VASCULAR_TORTUOSITY": "Retinal vascular tortuosity", "HP_RETINOSCHISIS": "Retinoschisis", "HP_RETROBULBAR_OPTIC_NEURITIS": "Retrobulbar optic neuritis", "HP_RETINOPATHY_OF_PREMATURITY": "Retinopathy of prematurity", "HP_RETROCEREBELLAR_CYST": "Retrocerebellar cyst", "HP_RETINOPATHY": "Retinopathy", "HP_RETROCOLLIS": "Retrocollis", "HP_RHABDOMYOMA": "Rhabdomyoma", "HP_RHABDOMYOLYSIS": "Rhabdomyolysis", "HP_RHEGMATOGENOUS_RETINAL_DETACHMENT": "Rhegmatogenous retinal detachment", "HP_RHEUMATOID_FACTOR_POSITIVE": "Rheumatoid factor positive", "HP_RETROGNATHIA": "Retrognathia", "HP_RHEUMATOID_ARTHRITIS": "Rheumatoid arthritis", "HP_RHINORRHEA": "Rhinorrhea", "HP_RHINITIS": "Rhinitis", "HP_RHIZOMELIC_ARM_SHORTENING": "Rhizomelic arm shortening", "HP_RHIZOMELIA": "Rhizomelia", "HP_RHOMBENCEPHALOSYNAPSIS": "Rhombencephalosynapsis", "HP_RIB_SEGMENTATION_ABNORMALITIES": "Rib segmentation abnormalities", "HP_RIB_FUSION": "Rib fusion", "HP_RIDGED_FINGERNAIL": "Ridged fingernail", "HP_RIDGED_NAIL": "Ridged nail", "HP_RICKETS": "Rickets", "HP_RIGHT_AORTIC_ARCH": "Right aortic arch", "HP_RIEGER_ANOMALY": "Rieger anomaly", "HP_RIGHT_AORTIC_ARCH_WITH_MIRROR_IMAGE_BRANCHING": "Right aortic arch with mirror image branching", "HP_RIGHT_ATRIAL_ENLARGEMENT": "Right atrial enlargement", "HP_RIGHT_BUNDLE_BRANCH_BLOCK": "", "HP_RIGHT_VENTRICULAR_CARDIOMYOPATHY": "Right ventricular cardiomyopathy", "HP_RIGHT_VENTRICULAR_DILATATION": "Right ventricular dilatation", "HP_RIGHT_VENTRICULAR_HYPERTROPHY": "Right ventricular hypertrophy", "HP_RING_SCOTOMA": "Ring scotoma", "HP_ROTARY_NYSTAGMUS": "Rotary nystagmus", "HP_RIMMED_VACUOLES": "Rimmed vacuoles", "HP_RIGIDITY": "Rigidity", "HP_ROUND_EAR": "Round ear", "HP_SACCADIC_OSCILLATION": "Saccadic oscillation", "HP_ROD_CONE_DYSTROPHY": "Rod-cone dystrophy", "HP_SACCADIC_SMOOTH_PURSUIT": "", "HP_ROUND_FACE": "Round face", "HP_SACROCOCCYGEAL_TERATOMA": "", "HP_SAGITTAL_CRANIOSYNOSTOSIS": "Sagittal craniosynostosis", "HP_SALIVARY_GLAND_NEOPLASM": "Salivary gland neoplasm", "HP_SANDWICH_APPEARANCE_OF_VERTEBRAL_BODIES": "Sandwich appearance of vertebral bodies", "HP_SCANNING_SPEECH": "Scanning speech", "HP_SANDAL_GAP": "Sandal gap", "HP_SCALING_SKIN": "Scaling skin", "HP_SCAPULOPERONEAL_AMYOTROPHY": "Scapuloperoneal amyotrophy", "HP_SARCOMA": "Sarcoma", "HP_SCAPHOCEPHALY": "Scaphocephaly", "HP_SCAPULAR_WINGING": "Scapular winging", "HP_SCARRING_ALOPECIA_OF_SCALP": "Scarring alopecia of scalp", "HP_SCARRING": "Scarring", "HP_SCHISTOCYTOSIS": "Schistocytosis", "HP_SCHIZENCEPHALY": "Schizencephaly", "HP_SCHWANNOMA": "Schwannoma", "HP_SCLERAL_STAPHYLOMA": "Scleral staphyloma", "HP_SCHIZOPHRENIA": "Schizophrenia", "HP_SCLEROCORNEA": "Sclerocornea", "HP_SCLERODACTYLY": "Sclerodactyly", "HP_SCLERODERMA": "Scleroderma", "HP_SCLEROSING_CHOLANGITIS": "Sclerosing cholangitis", "HP_SCLEROSIS_OF_FINGER_PHALANX": "Sclerosis of finger phalanx", "HP_SCLEROSIS_OF_HAND_BONE": "Sclerosis of hand bone", "HP_SCLEROSIS_OF_SKULL_BASE": "Sclerosis of skull base", "HP_SCLEROTIC_VERTEBRAL_ENDPLATES": "Sclerotic vertebral endplates", "HP_SCOTOMA": "Scotoma", "HP_SEA_BLUE_HISTIOCYTOSIS": "Sea-blue histiocytosis", "HP_SEBORRHEIC_DERMATITIS": "Seborrheic dermatitis", "HP_SECONDARY_GROWTH_HORMONE_DEFICIENCY": "Secondary growth hormone deficiency", "HP_SECOND_DEGREE_ATRIOVENTRICULAR_BLOCK": "Second degree atrioventricular block", "HP_SECONDARY_AMENORRHEA": "Secondary amenorrhea", "HP_SECRETORY_DIARRHEA": "Secretory diarrhea", "HP_SECOND_TRIMESTER_ONSET": "Second trimester onset", "HP_SECONDARY_MICROCEPHALY": "Secondary microcephaly", "HP_SECUNDUM_ATRIAL_SEPTAL_DEFECT": "Secundum atrial septal defect", "HP_SEESAW_NYSTAGMUS": "Seesaw nystagmus", "HP_SEGMENTAL_PERIPHERAL_DEMYELINATION_REMYELINATION": "Segmental peripheral demyelination/remyelination", "HP_SELF_BITING": "Self-biting", "HP_SELECTIVE_TOOTH_AGENESIS": "Selective tooth agenesis", "HP_SEMANTIC_DEMENTIA": "Semantic dementia", "HP_SEMILOBAR_HOLOPROSENCEPHALY": "Semilobar holoprosencephaly", "HP_SELF_MUTILATION": "Self-mutilation", "HP_SENILE_PLAQUES": "Senile plaques", "HP_SELF_INJURIOUS_BEHAVIOR": "Self-injurious behavior", "HP_SENSORY_ATAXIA": "Sensory ataxia", "HP_SENSORIMOTOR_NEUROPATHY": "Sensorimotor neuropathy", "HP_SENSORY_SEEKING": "Sensory seeking", "HP_SENSORY_NEUROPATHY": "Sensory neuropathy", "HP_SENSORY_AXONAL_NEUROPATHY": "Sensory axonal neuropathy", "HP_SEPTATE_VAGINA": "Septate vagina", "HP_SEPTO_OPTIC_DYSPLASIA": "Septo-optic dysplasia", "HP_SEPSIS": "Sepsis", "HP_SEPTIC_ARTHRITIS": "Septic arthritis", "HP_SENSORY_BEHAVIORAL_ABNORMALITY": "Sensory behavioral abnormality", "HP_SEROSITIS": "Serositis", "HP_SERTOLI_CELL_NEOPLASM": "Sertoli cell neoplasm", "HP_SEVERELY_REDUCED_VISUAL_ACUITY": "Severely reduced visual acuity", "HP_SEVERE_COMBINED_IMMUNODEFICIENCY": "Severe combined immunodeficiency", "HP_SEVERELY_REDUCED_LEFT_VENTRICULAR_EJECTION_FRACTION": "Severely reduced left ventricular ejection fraction", "HP_SEVERE_B_LYMPHOCYTOPENIA": "", "HP_SEVERE_CYTOMEGALOVIRUS_INFECTION": "Severe cytomegalovirus infection", "HP_SEVERE_DEMYELINATION_OF_THE_WHITE_MATTER": "Severe demyelination of the white matter", "HP_SEVERE_EPSTEIN_BARR_VIRUS_INFECTION": "", "HP_SEVERE_EXPRESSIVE_LANGUAGE_DELAY": "Severe expressive language delay", "HP_SEVERE_FAILURE_TO_THRIVE": "Severe failure to thrive", "HP_SEVERE_HEARING_IMPAIRMENT": "Severe hearing impairment", "HP_SEVERE_GLOBAL_DEVELOPMENTAL_DELAY": "Severe global developmental delay", "HP_SEVERE_INTRAUTERINE_GROWTH_RETARDATION": "Severe intrauterine growth retardation", "HP_SEVERE_INFECTION": "Severe infection", "HP_SEVERE_LACTIC_ACIDOSIS": "Severe lactic acidosis", "HP_SEVERE_PLATYSPONDYLY": "Severe platyspondyly", "HP_SEVERE_PHOTOSENSITIVITY": "Severe photosensitivity", "HP_SEVERE_MUSCULAR_HYPOTONIA": "Severe muscular hypotonia", "HP_SEVERE_SHORT_LIMB_DWARFISM": "Severe short-limb dwarfism", "HP_SEVERE_POSTNATAL_GROWTH_RETARDATION": "Severe postnatal growth retardation", "HP_SEVERE_SHORT_STATURE": "Severe short stature", "HP_SEVERE_VARICELLA_ZOSTER_INFECTION": "Severe varicella zoster infection", "HP_SEX_REVERSAL": "Sex reversal", "HP_SEVERE_TEMPER_TANTRUMS": "Severe temper tantrums", "HP_SHALLOW_ACETABULAR_FOSSAE": "Shallow acetabular fossae", "HP_SEVERE_VIRAL_INFECTION": "Severe viral infection", "HP_SHAGREEN_PATCH": "Shagreen patch", "HP_SHALLOW_ANTERIOR_CHAMBER": "Shallow anterior chamber", "HP_SHAWL_SCROTUM": "Shawl scrotum", "HP_SHALLOW_ORBITS": "Shallow orbits", "HP_SHORTENED_PR_INTERVAL": "Shortened PR interval", "HP_SHORTENED_QT_INTERVAL": "Shortened QT interval", "HP_SHIELD_CHEST": "Shield chest", "HP_SHOCK": "Shock", "HP_SHORT_1ST_METACARPAL": "Short 1st metacarpal", "HP_SHORTENING_OF_ALL_PHALANGES_OF_THE_TOES": "Shortening of all phalanges of the toes", "HP_SHORTENING_OF_ALL_DISTAL_PHALANGES_OF_THE_FINGERS": "Shortening of all distal phalanges of the fingers", "HP_SHORTENING_OF_ALL_MIDDLE_PHALANGES_OF_THE_FINGERS": "Shortening of all middle phalanges of the fingers", "HP_SHORT_4TH_METACARPAL": "Short 4th metacarpal", "HP_SHORT_4TH_TOE": "Short 4th toe", "HP_SHORT_5TH_TOE": "Short 5th toe", "HP_SHORT_COLUMELLA": "Short columella", "HP_SHORT_CLAVICLES": "Short clavicles", "HP_SHORT_CHIN": "Short chin", "HP_SHORT_FEMUR": "Short femur", "HP_SHORT_FACE": "Short face", "HP_SHORT_FIRST_METATARSAL": "Short first metatarsal", "HP_SHORT_GREATER_SCIATIC_NOTCH": "Short greater sciatic notch", "HP_SHORT_FOURTH_METATARSAL": "", "HP_SHORT_LINGUAL_FRENULUM": "Short lingual frenulum", "HP_SHORT_FOOT": "Short foot", "HP_SHORT_LOWER_LIMBS": "Short lower limbs", "HP_SHORT_DIGIT": "Short digit", "HP_SHORT_MANDIBULAR_RAMI": "Short mandibular rami", "HP_SHORT_MIDDLE_PHALANX_OF_THE_2ND_FINGER": "Short middle phalanx of the 2nd finger", "HP_SHORT_LONG_BONE": "Short long bone", "HP_SHORT_NAIL": "Short nail", "HP_SHORT_MIDDLE_PHALANX_OF_TOE": "Short middle phalanx of toe", "HP_SHORT_NASAL_BRIDGE": "Short nasal bridge", "HP_SHORT_PALM": "Short palm", "HP_SHORT_PALPEBRAL_FISSURE": "Short palpebral fissure", "HP_SHORT_PHALANX_OF_THE_THUMB": "Short phalanx of the thumb", "HP_SHORT_PROXIMAL_PHALANX_OF_FINGER": "Short proximal phalanx of finger", "HP_SHORT_NOSE": "Short nose", "HP_SHORT_PHILTRUM": "Short philtrum", "HP_SHORT_STEPPED_SHUFFLING_GAIT": "Short stepped shuffling gait", "HP_SHORT_STERNUM": "Short sternum", "HP_SHORT_SPERM_FLAGELLA": "Short sperm flagella", "HP_SHORT_RIBS": "Short ribs", "HP_SHORT_TELOMERE_LENGTH": "", "HP_SHORT_TERM_MEMORY_IMPAIRMENT": "Short term memory impairment", "HP_SHORT_THUMB": "Short thumb", "HP_SHORT_THORAX": "Short thorax", "HP_SHORT_TIBIA": "Short tibia", "HP_SHORT_TOE": "Short toe", "HP_SHORT_UMBILICAL_CORD": "Short umbilical cord", "HP_SHORT_UPPER_LIP": "Short upper lip", "HP_SHOULDER_CONTRACTURE": "Shoulder contracture", "HP_SHOULDER_DISLOCATION": "Shoulder dislocation", "HP_SHOULDER_GIRDLE_MUSCLE_ATROPHY": "Shoulder girdle muscle atrophy", "HP_SHOULDER_GIRDLE_MUSCLE_WEAKNESS": "Shoulder girdle muscle weakness", "HP_SHOULDER_PAIN": "Shoulder pain", "HP_SHUFFLING_GAIT": "Shuffling gait", "HP_SIDEROBLASTIC_ANEMIA": "Sideroblastic anemia", "HP_SICK_SINUS_SYNDROME": "Sick sinus syndrome", "HP_SILVER_GRAY_HAIR": "Silver-gray hair", "HP_SIMPLE_EAR": "Simple ear", "HP_SIMPLE_FEBRILE_SEIZURE": "Simple febrile seizure", "HP_SINGLE_LINEAGE_MYELODYSPLASIA": "Single lineage myelodysplasia", "HP_SINGLE_NARIS": "Single naris", "HP_SIMPLIFIED_GYRAL_PATTERN": "Simplified gyral pattern", "HP_SINGLE_VENTRICLE": "Single ventricle", "HP_SINUS_TACHYCARDIA": "Sinus tachycardia", "HP_SINUS_BRADYCARDIA": "Sinus bradycardia", "HP_SIRENOMELIA": "Sirenomelia", "HP_SINGLE_TRANSVERSE_PALMAR_CREASE": "Single transverse palmar crease", "HP_SKELETAL_DYSPLASIA": "Skeletal dysplasia", "HP_SKEWFOOT": "Skewfoot", "HP_SKELETAL_MYOPATHY": "Skeletal myopathy", "HP_SKELETAL_MUSCLE_HYPERTROPHY": "Skeletal muscle hypertrophy", "HP_SKELETAL_MUSCLE_ATROPHY": "Skeletal muscle atrophy", "HP_SKIN_APPENDAGE_NEOPLASM": "Skin appendage neoplasm", "HP_SKIN_DIMPLE": "Skin dimple", "HP_SKIN_PICKING": "Skin-picking", "HP_SKIN_EROSION": "Skin erosion", "HP_SKIN_NODULE": "Skin nodule", "HP_SKIN_PIT": "Skin pit", "HP_SKIN_PLAQUE": "Skin plaque", "HP_SKIN_TAGS": "Skin tags", "HP_SKIN_VESICLE": "Skin vesicle", "HP_SKIN_RASH": "Skin rash", "HP_SKIN_ULCER": "Skin ulcer", "HP_SKULL_ASYMMETRY": "Skull asymmetry", "HP_SLEEP_ABNORMALITY": "", "HP_SLEEP_RELATED_BREATHING_DISORDERS": "Sleep-related breathing disorders", "HP_SLEEP_WAKE_CYCLE_DISTURBANCE": "Sleep-wake cycle disturbance", "HP_SLENDER_BUILD": "Slender build", "HP_SLANTING_OF_THE_PALPEBRAL_FISSURE": "Slanting of the palpebral fissure", "HP_SLENDER_LONG_BONES_WITH_NARROW_DIAPHYSES": "Slender long bones with narrow diaphyses", "HP_SLENDER_FINGER": "Slender finger", "HP_SLENDER_TOE": "Slender toe", "HP_SLOWED_SLURRED_SPEECH": "Slowed slurred speech", "HP_SLENDER_LONG_BONE": "Slender long bone", "HP_SLOPING_FOREHEAD": "Sloping forehead", "HP_SLOW_DECREASE_IN_VISUAL_ACUITY": "Slow decrease in visual acuity", "HP_SLOW_PUPILLARY_LIGHT_RESPONSE": "Slow pupillary light response", "HP_SLOWLY_PROGRESSIVE": "Slowly progressive", "HP_SLOW_SACCADIC_EYE_MOVEMENTS": "Slow saccadic eye movements", "HP_SLURRED_SPEECH": "Slurred speech", "HP_SMALL_CEREBRAL_CORTEX": "Small cerebral cortex", "HP_SMALL_ANTERIOR_FONTANELLE": "Small anterior fontanelle", "HP_SMALL_BASAL_GANGLIA": "Small basal ganglia", "HP_SMALL_BOWEL_DIVERTICULA": "Small bowel diverticula", "HP_SMALL_EPIPHYSES": "Small epiphyses", "HP_SMALL_EARLOBE": "Small earlobe", "HP_SMALL_FORAMEN_MAGNUM": "Small foramen magnum", "HP_SMALL_FACE": "Small face", "HP_SMALL_FOREHEAD": "Small forehead", "HP_SMALL_INTESTINAL_POLYPOSIS": "Small intestinal polyposis", "HP_SMALL_INTESTINAL_DYSMOTILITY": "Small intestinal dysmotility", "HP_SMALL_INTESTINAL_STENOSIS": "Small intestinal stenosis", "HP_SMALL_FOR_GESTATIONAL_AGE": "Small for gestational age", "HP_SMALL_HAND": "Small hand", "HP_SMALL_JOINT_HYPERMOBILTY": "Small joint hypermobilty", "HP_SMALL_PITUITARY_GLAND": "Small pituitary gland", "HP_SMALL_NAIL": "Small nail", "HP_SMALL_PLACENTA": "Small placenta", "HP_SMALL_THENAR_EMINENCE": "Small thenar eminence", "HP_SMOOTH_TONGUE": "", "HP_SMALL_SCROTUM": "Small scrotum", "HP_SNORING": "Snoring", "HP_SOCIAL_AND_OCCUPATIONAL_DETERIORATION": "Social and occupational deterioration", "HP_SOFT_DOUGHY_SKIN": "Soft, doughy skin", "HP_SMOOTH_PHILTRUM": "Smooth philtrum", "HP_SOFT_SKIN": "Soft skin", "HP_SOFT_TISSUE_NEOPLASM": "Soft tissue neoplasm", "HP_SOFT_TISSUE_SARCOMA": "Soft tissue sarcoma", "HP_SOLITARY_MEDIAN_MAXILLARY_CENTRAL_INCISOR": "Solitary median maxillary central incisor", "HP_SOMNAMBULISM": "", "HP_SPARSE_BONE_TRABECULAE": "Sparse bone trabeculae", "HP_SPARSE_AXILLARY_HAIR": "Sparse axillary hair", "HP_SPARSE_BODY_HAIR": "Sparse body hair", "HP_SPARSE_EYELASHES": "Sparse eyelashes", "HP_SOMATIC_SENSORY_DYSFUNCTION": "Somatic sensory dysfunction", "HP_SPARSE_EYEBROW": "Sparse eyebrow", "HP_SPARSE_MEDIAL_EYEBROW": "Sparse medial eyebrow", "HP_SPARSE_LATERAL_EYEBROW": "Sparse lateral eyebrow", "HP_SPARSE_OR_ABSENT_EYELASHES": "Sparse or absent eyelashes", "HP_SPARSE_HAIR": "Sparse hair", "HP_SPASTIC_ATAXIA": "Spastic ataxia", "HP_SPARSE_SCALP_HAIR": "Sparse scalp hair", "HP_SPASTIC_DYSARTHRIA": "Spastic dysarthria", "HP_SPASTIC_DIPLEGIA": "Spastic diplegia", "HP_SPASTIC_HYPERACTIVE_BLADDER": "Spastic/hyperactive bladder", "HP_SPASTIC_GAIT": "Spastic gait", "HP_SPASTIC_PARAPARESIS": "", "HP_SPASTIC_PARAPARETIC_GAIT": "Spastic paraparetic gait", "HP_SPASTICITY": "Spasticity", "HP_SPASTIC_PARAPLEGIA": "Spastic paraplegia", "HP_SPASTIC_TETRAPARESIS": "Spastic tetraparesis", "HP_SPEECH_APRAXIA": "Speech apraxia", "HP_SPASTIC_TETRAPLEGIA": "Spastic tetraplegia", "HP_SPERMATOCYTE_MATURATION_ARREST": "Spermatocyte maturation arrest", "HP_SPEECH_ARTICULATION_DIFFICULTIES": "Speech articulation difficulties", "HP_SPERMATOGENESIS_MATURATION_ARREST": "Spermatogenesis maturation arrest", "HP_SPHEROCYTOSIS": "Spherocytosis", "HP_SPHEROPHAKIA": "Spherophakia", "HP_SPIDER_HEMANGIOMA": "Spider hemangioma", "HP_SPECIFIC_LEARNING_DISABILITY": "Specific learning disability", "HP_SPINAL_CANAL_STENOSIS": "Spinal canal stenosis", "HP_SPINAL_CORD_TUMOR": "Spinal cord tumor", "HP_SPINAL_CORD_COMPRESSION": "Spinal cord compression", "HP_SPINAL_CORD_LESION": "Spinal cord lesion", "HP_SPINAL_MUSCULAR_ATROPHY": "Spinal muscular atrophy", "HP_SPINOCEREBELLAR_TRACT_DEGENERATION": "Spinocerebellar tract degeneration", "HP_SPINAL_RIGIDITY": "Spinal rigidity", "HP_SPLANCHNIC_VEIN_THROMBOSIS": "Splanchnic vein thrombosis", "HP_SPINA_BIFIDA_OCCULTA": "Spina bifida occulta", "HP_SPLENIC_INFARCTION": "Splenic infarction", "HP_SPINAL_DYSRAPHISM": "Spinal dysraphism", "HP_SPLENIC_RUPTURE": "Splenic rupture", "HP_SPLIT_FOOT": "Split foot", "HP_SPLIT_NAIL": "Split nail", "HP_SPONDYLOEPIPHYSEAL_DYSPLASIA": "Spondyloepiphyseal dysplasia", "HP_SPOKEN_WORD_RECOGNITION_DEFICIT": "Spoken word recognition deficit", "HP_SPONDYLOEPIMETAPHYSEAL_DYSPLASIA": "Spondyloepimetaphyseal dysplasia", "HP_SPONDYLOLISTHESIS": "Spondylolisthesis", "HP_SPONDYLOLYSIS": "Spondylolysis", "HP_SPLENOMEGALY": "Splenomegaly", "HP_SPONTANEOUS_HEMATOMAS": "Spontaneous hematomas", "HP_SPONTANEOUS_HEMOLYTIC_CRISES": "Spontaneous hemolytic crises", "HP_SPONDYLOMETAPHYSEAL_DYSPLASIA": "Spondylometaphyseal dysplasia", "HP_SPONTANEOUS_PAIN_SENSATION": "Spontaneous pain sensation", "HP_SPONTANEOUS_RECURRENT_EPISTAXIS": "Spontaneous, recurrent epistaxis", "HP_SPONTANEOUS_PNEUMOTHORAX": "Spontaneous pneumothorax", "HP_SPOTTY_HYPERPIGMENTATION": "Spotty hyperpigmentation", "HP_SPORADIC": "Sporadic", "HP_SPOTTY_HYPOPIGMENTATION": "Spotty hypopigmentation", "HP_SQUARE_FACE": "Square face", "HP_SPRENGEL_ANOMALY": "Sprengel anomaly", "HP_SQUAMOUS_CELL_CARCINOMA_OF_THE_SKIN": "Squamous cell carcinoma of the skin", "HP_SQUARED_ILIAC_BONES": "Squared iliac bones", "HP_SQUAMOUS_CELL_CARCINOMA": "Squamous cell carcinoma", "HP_STAGE_5_CHRONIC_KIDNEY_DISEASE": "Stage 5 chronic kidney disease", "HP_STAPES_ANKYLOSIS": "Stapes ankylosis", "HP_STARING_GAZE": "Staring gaze", "HP_STATUS_EPILEPTICUS_WITHOUT_PROMINENT_MOTOR_SYMPTOMS": "Status epilepticus without prominent motor symptoms", "HP_STATUS_EPILEPTICUS": "Status epilepticus", "HP_STATUS_EPILEPTICUS_WITH_PROMINENT_MOTOR_SYMPTOMS": "Status epilepticus with prominent motor symptoms", "HP_STEATORRHEA": "", "HP_STEREOTYPICAL_BODY_ROCKING": "Stereotypical body rocking", "HP_STENOSIS_OF_THE_EXTERNAL_AUDITORY_CANAL": "Stenosis of the external auditory canal", "HP_STEPPAGE_GAIT": "Steppage gait", "HP_STEREOTYPIC_WHOLE_BODY_MOVEMENTS": "Stereotypic whole-body movements", "HP_STEREOTYPICAL_HAND_WRINGING": "", "HP_STEROETYPIC_MOVEMENTS_OF_FACE_AND_HEAD": "", "HP_STEROETYPIC_UPPER_EXTREMITY_MOVEMENTS": "", "HP_STEROID_RESISTANT_NEPHROTIC_SYNDROME": "Steroid-resistant nephrotic syndrome", "HP_STIFF_NECK": "Stiff neck", "HP_STIFF_SKIN": "Stiff skin", "HP_STILLBIRTH": "Stillbirth", "HP_STOMACH_CANCER": "Stomach cancer", "HP_STOMATOCYTOSIS": "Stomatocytosis", "HP_STOOPED_POSTURE": "Stooped posture", "HP_STOMATITIS": "Stomatitis", "HP_STREAK_OVARY": "Streak ovary", "HP_STRIAE_DISTENSAE": "Striae distensae", "HP_STUTTERING": "Stuttering", "HP_STROKE_LIKE_EPISODE": "Stroke-like episode", "HP_STRIDOR": "Stridor", "HP_STROKE": "Stroke", "HP_ST_SEGMENT_ELEVATION": "ST segment elevation", "HP_ST_SEGMENT_DEPRESSION": "ST segment depression", "HP_SUBACUTE_PROGRESSIVE_VIRAL_HEPATITIS": "Subacute progressive viral hepatitis", "HP_SUBARACHNOID_HEMORRHAGE": "Subarachnoid hemorrhage", "HP_SUBCORTICAL_BAND_HETEROTOPIA": "Subcortical band heterotopia", "HP_SUBCAPSULAR_CATARACT": "Subcapsular cataract", "HP_SUBCORTICAL_CEREBRAL_ATROPHY": "Subcortical cerebral atrophy", "HP_SUBCORTICAL_HETEROTOPIA": "Subcortical heterotopia", "HP_SUBCORTICAL_WHITE_MATTER_CALCIFICATIONS": "Subcortical white matter calcifications", "HP_SUBCUTANEOUS_LIPOMA": "Subcutaneous lipoma", "HP_SUBEPENDYMAL_CYSTS": "Subependymal cysts", "HP_SUBDURAL_HEMORRHAGE": "Subdural hemorrhage", "HP_SUBCUTANEOUS_NODULE": "Subcutaneous nodule", "HP_SUBEPIDERMAL_BLISTERING": "", "HP_SUBGLOTTIC_STENOSIS": "Subglottic stenosis", "HP_SUBCUTANEOUS_HEMORRHAGE": "Subcutaneous hemorrhage", "HP_SUBMUCOUS_CLEFT_SOFT_PALATE": "Submucous cleft soft palate", "HP_SUBRETINAL_DEPOSITS": "Subretinal deposits", "HP_SUBMUCOUS_CLEFT_PALATE": "Submucous cleft palate", "HP_SUBRETINAL_FLUID": "Subretinal fluid", "HP_SUBSTANTIA_NIGRA_GLIOSIS": "Substantia nigra gliosis", "HP_SUBSARCOLEMMAL_ACCUMULATIONS_OF_ABNORMALLY_SHAPED_MITOCHONDRIA": "Subsarcolemmal accumulations of abnormally shaped mitochondria", "HP_SUBUNGUAL_HYPERKERATOSIS": "Subungual hyperkeratosis", "HP_SUBVALVULAR_AORTIC_STENOSIS": "Subvalvular aortic stenosis", "HP_SUDDEN_LOSS_OF_VISUAL_ACUITY": "Sudden loss of visual acuity", "HP_SUDDEN_EPISODIC_APNEA": "Sudden episodic apnea", "HP_SUDDEN_DEATH": "Sudden death", "HP_SUNKEN_CHEEKS": "Sunken cheeks", "HP_SUDDEN_UNEXPECTED_DEATH_IN_EPILEPSY": "Sudden unexpected death in epilepsy", "HP_SUICIDAL_IDEATION": "Suicidal ideation", "HP_SUPERNUMERARY_CUSP": "Supernumerary cusp", "HP_SUPERNUMERARY_BONES_OF_THE_AXIAL_SKELETON": "Supernumerary bones of the axial skeleton", "HP_SUPERNUMERARY_MAXILLARY_INCISOR": "Supernumerary maxillary incisor", "HP_SUPERNUMERARY_NIPPLE": "Supernumerary nipple", "HP_SUPERNUMERARY_TOOTH": "Supernumerary tooth", "HP_SUPERNUMERARY_SPLEENS": "Supernumerary spleens", "HP_SUPRANUCLEAR_OPHTHALMOPLEGIA": "Supranuclear ophthalmoplegia", "HP_SUPRAVALVULAR_AORTIC_STENOSIS": "Supravalvular aortic stenosis", "HP_SUPRANUCLEAR_GAZE_PALSY": "Supranuclear gaze palsy", "HP_SUPRAVENTRICULAR_ARRHYTHMIA": "Supraventricular arrhythmia", "HP_SUTURAL_CATARACT": "Sutural cataract", "HP_SWAN_NECK_LIKE_DEFORMITIES_OF_THE_FINGERS": "Swan neck-like deformities of the fingers", "HP_SUPRAVENTRICULAR_TACHYCARDIA": "Supraventricular tachycardia", "HP_SWOLLEN_LIP": "Swollen lip", "HP_SYMPHALANGISM_OF_MIDDLE_PHALANX_OF_5TH_FINGER": "Symphalangism of middle phalanx of 5th finger", "HP_SYMPHALANGISM_AFFECTING_THE_PHALANGES_OF_THE_HAND": "Symphalangism affecting the phalanges of the hand", "HP_SYMPHALANGISM_OF_MIDDLE_PHALANX_OF_FINGER": "Symphalangism of middle phalanx of finger", "HP_SYNCOPE": "", "HP_SYMPTOMATIC_SEIZURES": "Symptomatic seizures", "HP_SYNKINESIS": "Synkinesis", "HP_SYNOSTOSIS_INVOLVING_BONES_OF_THE_FEET": "Synostosis involving bones of the feet", "HP_SYNOSTOSIS_INVOLVING_BONES_OF_THE_HAND": "Synostosis involving bones of the hand", "HP_SYNDACTYLY": "Syndactyly", "HP_SYNOSTOSIS_INVOLVING_BONES_OF_THE_UPPER_LIMBS": "Synostosis involving bones of the upper limbs", "HP_SYNOSTOSIS_INVOLVING_THE_ELBOW": "Synostosis involving the elbow", "HP_SYNOSTOSIS_OF_CARPALS_TARSALS": "Synostosis of carpals/tarsals", "HP_SYNOSTOSIS_OF_CARPAL_BONES": "Synostosis of carpal bones", "HP_SYNOSTOSIS_OF_METACARPALS_METATARSALS": "Synostosis of metacarpals/metatarsals", "HP_SYNOVIAL_LINING_HYPERPLASIA": "Synovial lining hyperplasia", "HP_SYRINGOMYELIA": "Syringomyelia", "HP_SYNOSTOSIS_OF_JOINTS": "Synostosis of joints", "HP_SYSTEMIC_LUPUS_ERYTHEMATOSUS": "Systemic lupus erythematosus", "HP_SYSTOLIC_HEART_MURMUR": "Systolic heart murmur", "HP_TACTILE_HYPERSENSITIVITY": "Tactile hypersensitivity", "HP_TALIPES_CALCANEOVALGUS": "Talipes calcaneovalgus", "HP_TALIPES_EQUINOVALGUS": "Talipes equinovalgus", "HP_TACHYPNEA": "Tachypnea", "HP_TACHYCARDIA": "Tachycardia", "HP_TALL_CHIN": "Tall chin", "HP_TALIPES_VALGUS": "Talipes valgus", "HP_TALIPES_EQUINOVARUS": "", "HP_TAPERED_DISTAL_PHALANGES_OF_FINGER": "", "HP_TALL_STATURE": "Tall stature", "HP_TAPERED_SPERM_HEAD": "Tapered sperm head", "HP_TAPERED_FINGER": "Tapered finger", "HP_TARSAL_SYNOSTOSIS": "Tarsal synostosis", "HP_TELANGIECTASIA_OF_THE_SKIN": "Telangiectasia of the skin", "HP_TEMPORAL_CORTICAL_ATROPHY": "Temporal cortical atrophy", "HP_TEMPORAL_OPTIC_DISC_PALLOR": "Temporal optic disc pallor", "HP_TELANGIECTASIA": "Telangiectasia", "HP_TEMPERATURE_INSTABILITY": "Temperature instability", "HP_TEMPORAL_PATTERN": "Temporal pattern", "HP_TEMPOROMANDIBULAR_JOINT_ANKYLOSIS": "", "HP_TELECANTHUS": "Telecanthus", "HP_TENDON_XANTHOMATOSIS": "Tendon xanthomatosis", "HP_TENDON_RUPTURE": "Tendon rupture", "HP_TERATOMA": "Teratoma", "HP_TENTED_UPPER_LIP_VERMILION": "Tented upper lip vermilion", "HP_TESSIER_CLEFT": "Tessier cleft", "HP_TESTICULAR_ADRENAL_REST_TUMOR": "Testicular adrenal rest tumor", "HP_TESTICULAR_DYSGENESIS": "", "HP_TESTICULAR_ATROPHY": "Testicular atrophy", "HP_TETANY": "Tetany", "HP_TETRAPLEGIA": "Tetraplegia", "HP_TETRAPARESIS": "Tetraparesis", "HP_TETRALOGY_OF_FALLOT": "Tetralogy of Fallot", "HP_THENAR_MUSCLE_ATROPHY": "Thenar muscle atrophy", "HP_THENAR_MUSCLE_WEAKNESS": "Thenar muscle weakness", "HP_THICKENED_CORTEX_OF_LONG_BONES": "Thickened cortex of long bones", "HP_TETRAPLEGIA_TETRAPARESIS": "Tetraplegia/tetraparesis", "HP_THICKENED_CALVARIA": "Thickened calvaria", "HP_THICKENED_EARS": "Thickened ears", "HP_THICKENED_GLOMERULAR_BASEMENT_MEMBRANE": "", "HP_THICKENED_RIBS": "Thickened ribs", "HP_THICKENED_HELICES": "Thickened helices", "HP_THICKENED_NUCHAL_SKIN_FOLD": "Thickened nuchal skin fold", "HP_THICK_CEREBRAL_CORTEX": "Thick cerebral cortex", "HP_THICK_CORPUS_CALLOSUM": "Thick corpus callosum", "HP_THICK_HAIR": "Thick hair", "HP_THICK_UPPER_LIP_VERMILION": "Thick upper lip vermilion", "HP_THICKENED_SKIN": "Thickened skin", "HP_THICK_EYEBROW": "Thick eyebrow", "HP_THICK_LOWER_LIP_VERMILION": "Thick lower lip vermilion", "HP_THICK_NASAL_ALAE": "Thick nasal alae", "HP_THINNING_OF_DESCEMET_MEMBRANE": "Thinning of Descemet membrane", "HP_THIN_BONY_CORTEX": "Thin bony cortex", "HP_THIN_CLAVICLES": "Thin clavicles", "HP_THICK_VERMILION_BORDER": "Thick vermilion border", "HP_THIN_EYEBROW": "Thin eyebrow", "HP_THIN_CORPUS_CALLOSUM": "", "HP_THIN_NAIL": "Thin nail", "HP_THIN_LOWER_LIP_VERMILION": "Thin lower lip vermilion", "HP_THIN_RIBS": "Thin ribs", "HP_THIN_SKIN": "Thin skin", "HP_THIRD_DEGREE_ATRIOVENTRICULAR_BLOCK": "Third degree atrioventricular block", "HP_THIRD_TRIMESTER_ONSET": "Third trimester onset", "HP_THORACIC_AORTA_CALCIFICATION": "Thoracic aorta calcification", "HP_THIN_VERMILION_BORDER": "Thin vermilion border", "HP_THIN_UPPER_LIP_VERMILION": "Thin upper lip vermilion", "HP_THORACIC_AORTIC_ANEURYSM": "Thoracic aortic aneurysm", "HP_THORACIC_DYSPLASIA": "Thoracic dysplasia", "HP_THORACIC_KYPHOSCOLIOSIS": "Thoracic kyphoscoliosis", "HP_THORACIC_KYPHOSIS": "Thoracic kyphosis", "HP_THORACIC_PLATYSPONDYLY": "Thoracic platyspondyly", "HP_THORACIC_HYPOPLASIA": "Thoracic hypoplasia", "HP_THORACIC_SCOLIOSIS": "Thoracic scoliosis", "HP_THORACOLUMBAR_KYPHOSCOLIOSIS": "Thoracolumbar kyphoscoliosis", "HP_THORACOLUMBAR_KYPHOSIS": "Thoracolumbar kyphosis", "HP_THORACOLUMBAR_SCOLIOSIS": "Thoracolumbar scoliosis", "HP_THROMBOCYTOSIS": "Thrombocytosis", "HP_THROMBOEMBOLIC_STROKE": "Thromboembolic stroke", "HP_THROMBOPHLEBITIS": "Thrombophlebitis", "HP_THROMBOEMBOLISM": "Thromboembolism", "HP_THYMUS_HYPERPLASIA": "Thymus hyperplasia", "HP_THYROID_ADENOMA": "Thyroid adenoma", "HP_THUMB_CONTRACTURE": "Thumb contracture", "HP_THYMOMA": "", "HP_THYROID_AGENESIS": "Thyroid agenesis", "HP_THYROIDITIS": "Thyroiditis", "HP_THYROID_CARCINOMA": "Thyroid carcinoma", "HP_THYROID_DYSGENESIS": "Thyroid dysgenesis", "HP_THYROID_DEFECT_IN_OXIDATION_AND_ORGANIFICATION_OF_IODIDE": "Thyroid defect in oxidation and organification of iodide", "HP_THYROTOXICOSIS_WITH_DIFFUSE_GOITER": "Thyrotoxicosis with diffuse goiter", "HP_TIBIALIS_ANTERIOR_MUSCLE_ATROPHY": "Tibialis anterior muscle atrophy", "HP_TIBIALIS_MUSCLE_WEAKNESS": "Tibialis muscle weakness", "HP_TICS": "Tics", "HP_TIBIAL_TORSION": "Tibial torsion", "HP_TIBIAL_BOWING": "Tibial bowing", "HP_TIGER_TAIL_BANDING": "Tiger tail banding", "HP_TINNITUS": "Tinnitus", "HP_TIP_TOE_GAIT": "Tip-toe gait", "HP_TOENAIL_DYSPLASIA": "Toenail dysplasia", "HP_TITUBATION": "Titubation", "HP_TISSUE_ISCHEMIA": "Tissue ischemia", "HP_TOE_CLINODACTYLY": "Toe clinodactyly", "HP_TOE_JOINT_CONTRACTURE": "Toe joint contracture", "HP_TOE_DEFORMITY": "Toe deformity", "HP_TONGUE_ATROPHY": "Tongue atrophy", "HP_TONGUE_NODULES": "Tongue nodules", "HP_TONGUE_THRUSTING": "Tongue thrusting", "HP_TOE_SYNDACTYLY": "Toe syndactyly", "HP_TOOTH_ABSCESS": "Tooth abscess", "HP_TONGUE_FASCICULATIONS": "Tongue fasciculations", "HP_TORSADE_DE_POINTES": "Torsade de pointes", "HP_TONIC_SEIZURE": "Tonic seizure", "HP_TORSION_DYSTONIA": "Torsion dystonia", "HP_TORTUOUS_CEREBRAL_ARTERIES": "Tortuous cerebral arteries", "HP_TOOTH_MALPOSITION": "Tooth malposition", "HP_TOTAL_OPHTHALMOPLEGIA": "Total ophthalmoplegia", "HP_TOXEMIA_OF_PREGNANCY": "Toxemia of pregnancy", "HP_TOTAL_ANOMALOUS_PULMONARY_VENOUS_RETURN": "Total anomalous pulmonary venous return", "HP_TRACHEAL_CALCIFICATION": "Tracheal calcification", "HP_TRACHEOBRONCHOMALACIA": "Tracheobronchomalacia", "HP_TRACHEAL_STENOSIS": "Tracheal stenosis", "HP_TRACHEOESOPHAGEAL_FISTULA": "Tracheoesophageal fistula", "HP_TRANSIENT_GLOBAL_AMNESIA": "Transient global amnesia", "HP_TRACHEOMALACIA": "Tracheomalacia", "HP_TRACTIONAL_RETINAL_DETACHMENT": "Tractional retinal detachment", "HP_TRANSIENT_HYPERPHENYLALANINEMIA": "Transient hyperphenylalaninemia", "HP_TRANSIENT_NEONATAL_DIABETES_MELLITUS": "Transient neonatal diabetes mellitus", "HP_TRANSIENT_NEUTROPENIA": "", "HP_TRANSIENT_ISCHEMIC_ATTACK": "Transient ischemic attack", "HP_TRANSPOSITION_OF_THE_GREAT_ARTERIES": "Transposition of the great arteries", "HP_TRIANGULAR_MOUTH": "Triangular mouth", "HP_TREMOR_BY_ANATOMICAL_SITE": "Tremor by anatomical site", "HP_TRIANGULAR_SHAPED_PHALANGES_OF_THE_HAND": "Triangular shaped phalanges of the hand", "HP_TRICEPS_WEAKNESS": "Triceps weakness", "HP_TRIANGULAR_FACE": "Triangular face", "HP_TREMOR": "Tremor", "HP_TRICHORRHEXIS_NODOSA": "Trichorrhexis nodosa", "HP_TRICUSPID_ATRESIA": "Tricuspid atresia", "HP_TRICUSPID_STENOSIS": "Tricuspid stenosis", "HP_TRICUSPID_VALVE_PROLAPSE": "Tricuspid valve prolapse", "HP_TRISMUS": "Trismus", "HP_TRIGONOCEPHALY": "Trigonocephaly", "HP_TRIPHALANGEAL_THUMB": "Triphalangeal thumb", "HP_TROPHIC_CHANGES_RELATED_TO_PAIN": "Trophic changes related to pain", "HP_TRUE_HERMAPHRODITISM": "True hermaphroditism", "HP_TRITANOMALY": "Tritanomaly", "HP_TRUNCAL_ATAXIA": "Truncal ataxia", "HP_TRUNCAL_TITUBATION": "Truncal titubation", "HP_TRUNCUS_ARTERIOSUS": "Truncus arteriosus", "HP_TRUNCAL_OBESITY": "Truncal obesity", "HP_TUBULOINTERSTITIAL_NEPHRITIS": "Tubulointerstitial nephritis", "HP_TURRICEPHALY": "Turricephaly", "HP_TUBE_FEEDING": "Tube feeding", "HP_TYPE_2_MUSCLE_FIBER_ATROPHY": "Type 2 muscle fiber atrophy", "HP_TYPE_1_MUSCLE_FIBER_ATROPHY": "Type 1 muscle fiber atrophy", "HP_TYPE_1_MUSCLE_FIBER_PREDOMINANCE": "Type 1 muscle fiber predominance", "HP_TYPE_2_MUSCLE_FIBER_PREDOMINANCE": "Type 2 muscle fiber predominance", "HP_TYPE_E_BRACHYDACTYLY": "Type E brachydactyly", "HP_TYPE_A_BRACHYDACTYLY": "Type A brachydactyly", "HP_TYPE_II_LISSENCEPHALY": "Type II lissencephaly", "HP_TYPE_II_DIABETES_MELLITUS": "Type II diabetes mellitus", "HP_TYPE_II_TRANSFERRIN_ISOFORM_PROFILE": "Type II transferrin isoform profile", "HP_TYPE_I_TRANSFERRIN_ISOFORM_PROFILE": "Type I transferrin isoform profile", "HP_TYPE_I_DIABETES_MELLITUS": "Type I diabetes mellitus", "HP_TYPICALLY_DE_NOVO": "Typically de novo", "HP_TYPICAL_ABSENCE_SEIZURE": "Typical absence seizure", "HP_T_CELL_LYMPHOMA": "T-cell lymphoma", "HP_TYPIFIED_BY_INCOMPLETE_PENETRANCE": "Typified by incomplete penetrance", "HP_T_LYMPHOCYTOPENIA": "", "HP_T_WAVE_INVERSION": "T-wave inversion", "HP_ULCERATIVE_COLITIS": "", "HP_TYPIFIED_BY_SOMATIC_MOSAICISM": "Typified by somatic mosaicism", "HP_ULNAR_BOWING": "Ulnar bowing", "HP_ULNAR_CLAW": "Ulnar claw", "HP_ULNAR_DEVIATION_OF_FINGER": "Ulnar deviation of finger", "HP_ULNAR_DEVIATION_OF_THE_HAND": "Ulnar deviation of the hand", "HP_ULNAR_DEVIATION_OF_THE_2ND_FINGER": "Ulnar deviation of the 2nd finger", "HP_ULNAR_DEVIATION_OF_THE_HAND_OR_OF_FINGERS_OF_THE_HAND": "Ulnar deviation of the hand or of fingers of the hand", "HP_UNCOMBABLE_HAIR": "Uncombable hair", "HP_ULNAR_DEVIATION_OF_THE_WRIST": "Ulnar deviation of the wrist", "HP_UNBALANCED_ATRIOVENTRICULAR_CANAL_DEFECT": "Unbalanced atrioventricular canal defect", "HP_UNCONTROLLED_EYE_MOVEMENTS": "Uncontrolled eye movements", "HP_UNCONJUGATED_HYPERBILIRUBINEMIA": "Unconjugated hyperbilirubinemia", "HP_UNDERFOLDED_HELIX": "Underfolded helix", "HP_UNDERDEVELOPED_SUPRAORBITAL_RIDGES": "Underdeveloped supraorbital ridges", "HP_UNDETECTABLE_ELECTRORETINOGRAM": "Undetectable electroretinogram", "HP_UNDETECTABLE_LIGHT_ADAPTED_ELECTRORETINOGRAM": "Undetectable light-adapted electroretinogram", "HP_UNDETECTABLE_LIGHT_AND_DARK_ADAPTED_ELECTRORETINOGRAM": "Undetectable light- and dark-adapted electroretinogram", "HP_UNDETECTABLE_VISUAL_EVOKED_POTENTIALS": "Undetectable visual evoked potentials", "HP_UNEXPLAINED_FEVERS": "Unexplained fevers", "HP_UNICORONAL_SYNOSTOSIS": "Unicoronal synostosis", "HP_UNILATERAL_CLEFT_PALATE": "Unilateral cleft palate", "HP_UNILATERAL_CLEFT_LIP": "Unilateral cleft lip", "HP_UNILATERAL_PRIMARY_PULMONARY_DYSGENESIS": "Unilateral primary pulmonary dysgenesis", "HP_UNILATERAL_CRYPTORCHIDISM": "Unilateral cryptorchidism", "HP_UNILATERAL_PTOSIS": "Unilateral ptosis", "HP_UNILATERAL_RENAL_AGENESIS": "Unilateral renal agenesis", "HP_UNILATERAL_RENAL_HYPOPLASIA": "Unilateral renal hypoplasia", "HP_UNUSUAL_FUNGAL_INFECTION": "Unusual fungal infection", "HP_UNUSUAL_SKIN_INFECTION": "Unusual skin infection", "HP_UNSTEADY_GAIT": "Unsteady gait", "HP_UPGAZE_PALSY": "Upgaze palsy", "HP_UNUSUAL_INFECTION_BY_ANATOMICAL_SITE": "Unusual infection by anatomical site", "HP_UNUSUAL_VIRUS_REACTIVATION": "Unusual virus reactivation", "HP_UPLIFTED_EARLOBE": "Uplifted earlobe", "HP_UPPER_AIRWAY_OBSTRUCTION": "Upper airway obstruction", "HP_UPPER_EXTREMITY_JOINT_DISLOCATION": "Upper extremity joint dislocation", "HP_UNUSUAL_INFECTION": "Unusual infection", "HP_UPPER_EYELID_COLOBOMA": "Upper eyelid coloboma", "HP_UPPER_EYELID_EDEMA": "Upper eyelid edema", "HP_UPPER_LIMB_HYPERTONIA": "Upper limb hypertonia", "HP_UPPER_LIMB_AMYOTROPHY": "Upper limb amyotrophy", "HP_UPPER_LIMB_ASYMMETRY": "Upper limb asymmetry", "HP_UPPER_LIMB_PAIN": "Upper limb pain", "HP_UPPER_LIMB_POSTURAL_TREMOR": "Upper limb postural tremor", "HP_UPPER_LIMB_MUSCLE_WEAKNESS": "Upper limb muscle weakness", "HP_UPPER_LIMB_JOINT_CONTRACTURE": "Upper-limb joint contracture", "HP_UPPER_LIMB_UNDERGROWTH": "Upper limb undergrowth", "HP_UPPER_LIMB_SPASTICITY": "Upper limb spasticity", "HP_URETERAL_OBSTRUCTION": "Ureteral obstruction", "HP_URETERAL_DUPLICATION": "Ureteral duplication", "HP_URETERAL_STENOSIS": "Ureteral stenosis", "HP_URETEROCELE": "Ureterocele", "HP_UPSLANTED_PALPEBRAL_FISSURE": "Upslanted palpebral fissure", "HP_URETEROPELVIC_JUNCTION_OBSTRUCTION": "Ureteropelvic junction obstruction", "HP_URETHRAL_ATRESIA": "Urethral atresia", "HP_URETHRAL_FISTULA": "Urethral fistula", "HP_URETHRAL_DIVERTICULUM": "Urethral diverticulum", "HP_UPPER_MOTOR_NEURON_DYSFUNCTION": "Upper motor neuron dysfunction", "HP_URETHRAL_STRICTURE": "Urethral stricture", "HP_URETHRAL_OBSTRUCTION": "Urethral obstruction", "HP_URETHRAL_VALVE": "Urethral valve", "HP_URETHRAL_STENOSIS": "Urethral stenosis", "HP_URETHROVAGINAL_FISTULA": "Urethrovaginal fistula", "HP_URETHROVESICAL_OCCLUSION": "Urethrovesical occlusion", "HP_URIC_ACID_NEPHROLITHIASIS": "Uric acid nephrolithiasis", "HP_URINARY_BLADDER_SPHINCTER_DYSFUNCTION": "Urinary bladder sphincter dysfunction", "HP_URINARY_RETENTION": "Urinary retention", "HP_URINARY_INCONTINENCE": "Urinary incontinence", "HP_URINARY_TRACT_NEOPLASM": "Urinary tract neoplasm", "HP_UROGENITAL_SINUS_ANOMALY": "Urogenital sinus anomaly", "HP_URINARY_URGENCY": "Urinary urgency", "HP_USUAL_INTERSTITIAL_PNEUMONIA": "Usual interstitial pneumonia", "HP_UROGENITAL_FISTULA": "Urogenital fistula", "HP_UTERINE_LEIOMYOMA": "Uterine leiomyoma", "HP_URTICARIA": "Urticaria", "HP_UTERINE_RUPTURE": "Uterine rupture", "HP_UTERINE_PROLAPSE": "", "HP_UTERUS_DIDELPHYS": "Uterus didelphys", "HP_UVEAL_ECTROPION": "Uveal ectropion", "HP_UVEAL_MELANOMA": "Uveal melanoma", "HP_UVEITIS": "Uveitis", "HP_U_SHAPED_UPPER_LIP_VERMILION": "U-Shaped upper lip vermilion", "HP_VACUOLATED_LYMPHOCYTES": "Vacuolated lymphocytes", "HP_VAGINAL_ATRESIA": "Vaginal atresia", "HP_VAGINAL_FISTULA": "Vaginal fistula", "HP_VAGINAL_NEOPLASM": "Vaginal neoplasm", "HP_VARIABLE_EXPRESSIVITY": "Variable expressivity", "HP_VARICOSE_VEINS": "Varicose veins", "HP_VASCULAR_CALCIFICATION": "Vascular calcification", "HP_VASCULAR_DILATATION": "Vascular dilatation", "HP_VASCULAR_GRANULAR_OSMIOPHILIC_MATERIAL_DEPOSITION": "Vascular granular osmiophilic material deposition", "HP_VASCULAR_TORTUOSITY": "Vascular tortuosity", "HP_VASCULITIS_BY_ANATOMICAL_SITE": "Vasculitis by anatomical site", "HP_VASCULAR_NEOPLASM": "Vascular neoplasm", "HP_VASCULITIS": "Vasculitis", "HP_VEGETATIVE_STATE": "Vegetative state", "HP_VASCULITIS_IN_THE_SKIN": "Vasculitis in the skin", "HP_VEIN_OF_GALEN_ANEURYSMAL_MALFORMATION": "", "HP_VASCULAR_SKIN_ABNORMALITY": "Vascular skin abnormality", "HP_VELOPHARYNGEAL_INSUFFICIENCY": "Velopharyngeal insufficiency", "HP_VENOUS_MALFORMATION": "Venous malformation", "HP_VENOUS_INSUFFICIENCY": "Venous insufficiency", "HP_VENTILATOR_DEPENDENCE_WITH_INABILITY_TO_WEAN": "Ventilator dependence with inability to wean", "HP_VENOUS_THROMBOSIS": "Venous thrombosis", "HP_VENTRICULAR_ESCAPE_RHYTHM": "Ventricular escape rhythm", "HP_VENTRICULAR_ARRHYTHMIA": "Ventricular arrhythmia", "HP_VENTRICULAR_FIBRILLATION": "Ventricular fibrillation", "HP_VENTRICULAR_SEPTAL_HYPERTROPHY": "Ventricular septal hypertrophy", "HP_VENTRICULAR_HYPERTROPHY": "Ventricular hypertrophy", "HP_VERRUCAE": "Verrucae", "HP_VERTEBRAL_ARCH_ANOMALY": "Vertebral arch anomaly"}