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# CREMI - Circuit Reconstruction from Electron Microscopy Images

## Dataset Description

CREMI is a benchmark dataset for evaluating algorithms for automatic reconstruction of neurons and neuronal connectivity from serial section electron microscopy data.

### Modality
- Serial section Transmission Electron Microscopy (ssTEM)

### Anatomy
- Adult Drosophila melanogaster brain

### Segmentation Targets
- **Neuron segmentation** (`volumes/labels/neuron_ids`)
- **Synaptic cleft segmentation** (`volumes/labels/clefts`)

### Volume Size
- 125 slices × 1250 × 1250 pixels per sample
- Resolution: 4×4×40 nm (x,y,z)

## Dataset Structure

```

CREMI/

└── train/

    ├── sample_A.hdf    # 167 MB

    ├── sample_B.hdf    # 160 MB

    └── sample_C.hdf    # 165 MB

```

Note: Test files (A+, B+, C+) are not included as they have no labels.

## HDF5 Structure

Each training file contains:
- `volumes/raw`: (125, 1250, 1250) uint8 - grayscale EM images
- `volumes/labels/neuron_ids`: (125, 1250, 1250) uint64 - neuron instance segmentation
- `volumes/labels/clefts`: (125, 1250, 1250) uint64 - synaptic cleft segmentation
- `annotations/` - synaptic partner annotations

## Usage

```python

import h5py

from huggingface_hub import hf_hub_download



# Download a training volume

path = hf_hub_download(

    repo_id="Angelou0516/CREMI",

    filename="train/sample_A.hdf",

    repo_type="dataset"

)



# Load data

with h5py.File(path, 'r') as f:

    raw = f['volumes/raw'][:]  # (125, 1250, 1250)

    neuron_ids = f['volumes/labels/neuron_ids'][:]  # (125, 1250, 1250)

    clefts = f['volumes/labels/clefts'][:]  # (125, 1250, 1250)

```

## Citation

```bibtex

@misc{cremi2016,

    title={CREMI: MICCAI Challenge on Circuit Reconstruction from Electron Microscopy Images},

    author={Funke, Jan and Saalfeld, Stephan and Bock, Davi and Turaga, Srini and Perlman, Eric},

    year={2016},

    url={https://cremi.org/}

}

```

## License

Please refer to the original dataset website: https://cremi.org/

## Links
- [CREMI Challenge Website](https://cremi.org/)
- [CREMI Data Page](https://cremi.org/data/)
- [CREMI Metrics](https://cremi.org/metrics/)