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Add dataset card

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  ---
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- dataset_info:
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- features:
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- - name: sample_id
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- dtype: string
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- - name: tissue
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- dtype:
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- class_label:
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- names:
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- '0': BC
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- '1': Bladder
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- '2': Lung
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- - name: subset
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- dtype: string
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- - name: ihc
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- dtype: image
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- - name: hematoxylin
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- dtype: image
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- - name: dapi
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- dtype: image
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- - name: lap2
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- dtype: image
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- - name: marker
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- dtype: image
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- - name: seg_mask
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- dtype: image
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- splits:
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- - name: train
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- num_bytes: 819179421
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- num_examples: 575
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- - name: validation
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- num_bytes: 130744578
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- num_examples: 91
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- - name: test
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- num_bytes: 825956215
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- num_examples: 598
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- - name: bc_train
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- num_bytes: 592905848
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- num_examples: 385
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- - name: bc_validation
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- num_bytes: 98729586
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- num_examples: 66
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- download_size: 2467676469
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- dataset_size: 2467515648
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- configs:
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- - config_name: default
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- data_files:
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- - split: train
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- path: data/train-*
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- - split: validation
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- path: data/validation-*
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- - split: test
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- path: data/test-*
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- - split: bc_train
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- path: data/bc_train-*
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- - split: bc_validation
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- path: data/bc_validation-*
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  ---
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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  ---
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+ license: cc-by-4.0
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+ task_categories:
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+ - image-segmentation
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+ tags:
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+ - medical
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+ - histopathology
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+ - immunohistochemistry
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+ - ihc
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+ - multiplex-immunofluorescence
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+ - ki67
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+ - cell-segmentation
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+ - deepliif
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+ pretty_name: DeepLIIF
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+ size_categories:
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+ - 1K<n<10K
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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  ---
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+
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+ # DeepLIIF (Deep Learning-Inferred Immunofluorescence)
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+
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+ Co-registered IHC (Ki67-DAB brightfield) and multiplex immunofluorescence (mpIF)
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+ patches with cell-level segmentation + classification ground truth for
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+ quantification of clinical pathology slides.
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+
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+ Source paper: Ghahremani et al., "Deep learning-inferred multiplex
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+ immunofluorescence for immunohistochemical image quantification,"
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+ *Nature Machine Intelligence* 4(4):401-412, 2022.
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+ DOI: [10.1038/s42256-022-00471-x](https://doi.org/10.1038/s42256-022-00471-x).
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+ Zenodo: <https://zenodo.org/records/4751737>.
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+
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+ ## Overview
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+ - **Modality:** Histopathology - IHC brightfield + co-registered mpIF (DAPI, Lap2, Ki67 marker)
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+ - **Patch size:** 512x512 each (originals are 3072x512 PNGs concatenating six panels)
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+ - **Tissue:** Bladder + Lung (main DeepLIIF), Breast carcinoma (BC-DeepLIIF subset)
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+ - **Total samples:** 1,715
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+ - `train` (DeepLIIF): 575
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+ - `validation` (DeepLIIF): 91
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+ - `test` (DeepLIIF): 598
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+ - `bc_train` (BC-DeepLIIF, breast): 385
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+ - `bc_validation` (BC-DeepLIIF, breast): 66
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+
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+ ## Columns
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+ | Column | Type | Notes |
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+ |---|---|---|
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+ | `sample_id` | string | Original PNG stem |
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+ | `tissue` | ClassLabel(3) | `0=BC`, `1=Bladder`, `2=Lung` |
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+ | `subset` | string | `DeepLIIF` (main) or `BC-DeepLIIF` |
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+ | `ihc` | Image (RGB) | Input - 512x512 brightfield Ki67-DAB IHC |
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+ | `hematoxylin` | Image (RGB) | Aux target - reconstructed hematoxylin channel |
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+ | `dapi` | Image (RGB) | Aux target - mpIF DAPI nuclear stain |
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+ | `lap2` | Image (RGB) | Aux target - mpIF Lap2 nuclear-envelope stain |
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+ | `marker` | Image (RGB) | Aux target - mpIF Ki67 marker channel |
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+ | `seg_mask` | Image (RGB) | **Ground truth** - red=Ki67+ cell, blue=Ki67- cell, green=boundary, black=background |
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+
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+ ## Ground Truth
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+ The `seg_mask` column is the canonical GT. It was generated by combining
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+ per-modality instance segmentations from mpIF DAPI + Lap2 + Hematoxylin + IHC,
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+ with instance boundaries initialized by the ImPartial interactive framework on
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+ DAPI. Cells are then classified red/blue based on Ki67 marker positivity.
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+
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+ For binary semantic segmentation (nucleus vs background) treat (red OR blue)
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+ pixels as foreground. For positive-vs-negative classification, decode red and
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+ blue channels separately.
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+
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+ ## Derivation
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+ Each source PNG was sliced column-wise into six 512x512 panels:
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+ - Columns [0:512] -> `ihc`
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+ - Columns [512:1024] -> `hematoxylin`
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+ - Columns [1024:1536] -> `dapi`
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+ - Columns [1536:2048] -> `lap2`
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+ - Columns [2048:2560] -> `marker`
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+ - Columns [2560:3072] -> `seg_mask`
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+
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+ No other preprocessing.
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+
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+ ## License
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+ CC BY 4.0 (dataset, per Zenodo record 4751737). The DeepLIIF code repo is
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+ Apache 2.0 with Commons Clause; that license applies only to code/models, not
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+ to this imaging data.
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+
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+ ## Citation
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+ ```bibtex
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+ @article{ghahremani2022deep,
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+ title={Deep learning-inferred multiplex immunofluorescence for
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+ immunohistochemical image quantification},
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+ author={Ghahremani, Parmida and Li, Yanyun and Kaufman, Arie and
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+ Vanguri, Rami and Greenwald, Noah and Angelo, Michael and
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+ Hollmann, Travis J and Nadeem, Saad},
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+ journal={Nature Machine Intelligence},
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+ volume={4}, number={4}, pages={401--412}, year={2022},
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+ doi={10.1038/s42256-022-00471-x}
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+ }
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+ ```