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README.md
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- name: sample_id
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dtype: string
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splits:
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- name: fold1
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num_bytes: 306763992
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num_examples: 2656
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- name: fold2
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num_bytes: 288997343
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num_examples: 2523
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- name: fold3
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num_bytes: 316302533
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num_examples: 2722
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download_size: 911961186
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dataset_size: 912063868
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configs:
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- config_name: default
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data_files:
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- split: fold1
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path: data/fold1-*
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- split: fold2
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path: data/fold2-*
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- split: fold3
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path: data/fold3-*
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---
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---
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license: cc-by-nc-sa-4.0
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task_categories:
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- image-segmentation
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tags:
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- medical
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- histopathology
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- h-and-e
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- nuclei
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- instance-segmentation
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- pan-cancer
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- tcga
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- gtex
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size_categories:
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- 1K<n<10K
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---
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# PanNuke
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Pan-Cancer H&E Nuclei Instance Segmentation and Classification dataset
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(Gamper et al., ECDP 2019; arXiv:2003.10778). Mirrored from the
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[Warwick TIA Centre release](https://warwick.ac.uk/fac/cross_fac/tia/data/pannuke).
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## Composition
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- **7,901** RGB patches of 256x256 at 40x magnification (~0.25 um/pixel)
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- **19** tissue types pooled from TCGA / GTEx (Breast, Colon, Lung, Kidney,
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Prostate, Stomach, Ovarian, Bladder, Esophagus, Pancreatic, Thyroid, Skin,
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Cervix, Adrenal_gland, Bile-duct, Liver, HeadNeck, Testis, Uterus)
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- **~189,744** annotated nuclei, multi-pathologist QC
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- **3 folds** (PanNuke is designed for 3-fold cross-validation):
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- `fold1`: 2,656 patches
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- `fold2`: 2,523 patches
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- `fold3`: 2,722 patches
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## Schema
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| Field | Type | Description |
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|---------------|-------------------------------|-------------------------------------------------------|
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| `image` | PIL RGB 256x256 | H&E patch, uint8 |
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| `inst_map` | PIL grayscale uint16 256x256 | Global per-pixel instance ID (0 = background) |
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| `type_map` | PIL grayscale uint8 256x256 | Semantic class per pixel (see table below) |
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| `tissue` | int | Tissue ID 0-18 (alphabetical) |
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| `tissue_name` | str | Tissue type name |
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| `fold` | int | Source fold (1, 2, or 3) |
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| `sample_id` | str | Unique ID, `foldN_NNNN` |
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### Semantic class encoding (`type_map`)
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| Value | Class |
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|-------|--------------------------|
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| 0 | Background |
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| 1 | Neoplastic |
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| 2 | Inflammatory |
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| 3 | Connective / Soft tissue |
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| 4 | Dead |
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| 5 | Epithelial |
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### Instance map (`inst_map`)
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Each connected nucleus is assigned a unique 16-bit integer ID per patch
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(starting from 1). IDs are derived from the original 6-channel mask
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arrays released by Warwick: for each foreground class channel, instance
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IDs are offset by the running count of nuclei in previous channels so
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the result is globally unique within the patch.
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## License
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CC BY-NC-SA 4.0 (research / non-commercial use). Same license as the
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original Warwick release.
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## Citation
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```bibtex
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@article{gamper2020pannuke,
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title={PanNuke Dataset Extension, Insights and Baselines},
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author={Gamper, Jevgenij and Koohbanani, Navid Alemi and Graham, Simon and Jahanifar, Mostafa and Benet, Ksenija and Khurram, Syed Ali and Azam, Ayesha and Hewitt, Katherine and Rajpoot, Nasir},
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journal={arXiv preprint arXiv:2003.10778},
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year={2020}
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}
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@inproceedings{gamper2019pannuke,
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title={Pannuke: An open pan-cancer histology dataset for nuclei instance segmentation and classification},
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author={Gamper, Jevgenij and Koohbanani, Navid Alemi and Benet, Ksenija and Khuram, Ali and Rajpoot, Nasir},
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booktitle={European Congress on Digital Pathology},
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pages={11--19},
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year={2019},
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organization={Springer}
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}
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```
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