{
  "train_drugs": [
    "2-Methoxyestradiol",
    "A-366",
    "ABT-737",
    "AG-490",
    "AMG-900",
    "AR-42",
    "AT9283",
    "AZ",
    "AZD1480",
    "Abexinostat",
    "Alisertib",
    "Altretamine",
    "Alvespimycin",
    "Aminoglutethimide",
    "Anacardic",
    "Andarine",
    "Aurora",
    "Avagacestat",
    "BMS-265246",
    "BMS-536924",
    "BMS-911543",
    "BRD4770",
    "Barasertib",
    "Baricitinib",
    "Bisindolylmaleimide",
    "Bosutinib",
    "Busulfan",
    "CEP-33779",
    "CUDC-907",
    "CYC116",
    "Capecitabine",
    "Carmofur",
    "Cediranib",
    "Celecoxib",
    "Cerdulatinib",
    "Clevudine",
    "Costunolide",
    "Crizotinib",
    "Curcumin",
    "Cyclocytidine",
    "Dacinostat",
    "Danusertib",
    "Dasatinib",
    "Decitabine",
    "Disulfiram",
    "Divalproex",
    "Droxinostat",
    "EED226",
    "ENMD-2076",
    "Ellagic",
    "Entacapone",
    "Entinostat",
    "Enzastaurin",
    "Epothilone",
    "FLLL32",
    "Fasudil",
    "Fedratinib",
    "Filgotinib",
    "Flavopiridol",
    "Fluorouracil",
    "Fulvestrant",
    "G007-LK",
    "GSK",
    "GSK1070916",
    "Gandotinib",
    "Givinostat",
    "Glesatinib?(MGCD265)",
    "Hesperadin",
    "IOX2",
    "ITSA-1",
    "Iniparib",
    "Ivosidenib",
    "JQ1",
    "KW-2449",
    "Ki16425",
    "Ki8751",
    "Lapatinib",
    "Lenalidomide",
    "Linifanib",
    "Lomustine",
    "Luminespib",
    "M344",
    "MC1568",
    "MK-0752",
    "MK-5108",
    "Maraviroc",
    "Meprednisone",
    "Mercaptopurine",
    "Mesna",
    "Mocetinostat",
    "Motesanib",
    "Navitoclax",
    "Nilotinib",
    "Obatoclax",
    "Ofloxacin",
    "PCI-34051",
    "PD173074",
    "PD98059",
    "PF-3845",
    "PF-573228",
    "PFI-1",
    "PJ34",
    "Panobinostat",
    "Patupilone",
    "Pelitinib",
    "Pirarubicin",
    "Pracinostat",
    "Prednisone",
    "Quercetin",
    "Quisinostat",
    "RG108",
    "Ramelteon",
    "Regorafenib",
    "Resminostat",
    "Resveratrol",
    "Rigosertib",
    "Roscovitine",
    "Rucaparib",
    "Ruxolitinib",
    "S-Ruxolitinib",
    "S3I-201",
    "SGI-1776",
    "SL-327",
    "SNS-314",
    "SRT1720",
    "SRT2104",
    "SRT3025",
    "Selisistat",
    "Sirtinol",
    "Sorafenib",
    "Streptozotocin",
    "TAK-901",
    "TG101209",
    "TGX-221",
    "Tacedinaline",
    "Tanespimycin",
    "Tazemetostat",
    "Temsirolimus",
    "Thalidomide",
    "Thiotepa",
    "Tie2",
    "Tofacitinib",
    "Tozasertib",
    "Trametinib",
    "Tranylcypromine",
    "Triamcinolone",
    "Trichostatin",
    "Tubastatin",
    "Tucidinostat",
    "UNC0379",
    "UNC0631",
    "UNC1999",
    "Valproic",
    "Vandetanib",
    "Veliparib",
    "WHI-P154",
    "WP1066",
    "XAV-939",
    "YM155",
    "ZM",
    "Zileuton"
  ],
  "ood_drugs": [
    "AC480",
    "AG-14361",
    "AICAR",
    "Alendronate",
    "Amisulpride",
    "Azacitidine",
    "BMS-754807",
    "Belinostat",
    "CUDC-101",
    "Cimetidine",
    "Daphnetin",
    "GSK-LSD1",
    "INO-1001",
    "JNJ-26854165",
    "JNJ-7706621",
    "MLN8054",
    "Momelotinib",
    "NVP-BSK805",
    "Nintedanib",
    "PHA-680632",
    "Raltitrexed",
    "Roxadustat",
    "SB431542",
    "TMP195",
    "Toremifene"
  ],
  "seed": 1,
  "n_train": 161,
  "n_ood": 25,
  "stratum_counts": {
    "PKC signaling": {
      "eligible": 3,
      "ood": 1
    },
    "Epigenetic regulation": {
      "eligible": 46,
      "ood": 5
    },
    "Cell cycle regulation": {
      "eligible": 21,
      "ood": 3
    },
    "Other": {
      "eligible": 6,
      "ood": 1
    },
    "Tyrosine kinase signaling": {
      "eligible": 29,
      "ood": 3
    },
    "JAK/STAT signaling": {
      "eligible": 22,
      "ood": 2
    },
    "Focal adhesion signaling": {
      "eligible": 2,
      "ood": 0
    },
    "Protein folding & Protein degradation": {
      "eligible": 7,
      "ood": 0
    },
    "HIF signaling": {
      "eligible": 3,
      "ood": 1
    },
    "DNA damage & DNA repair": {
      "eligible": 19,
      "ood": 3
    },
    "Apoptotic regulation": {
      "eligible": 5,
      "ood": 1
    },
    "Nuclear receptor signaling": {
      "eligible": 6,
      "ood": 1
    },
    "Antioxidant": {
      "eligible": 4,
      "ood": 1
    },
    "TGF/BMP signaling": {
      "eligible": 3,
      "ood": 1
    },
    "Neuronal signaling": {
      "eligible": 4,
      "ood": 1
    },
    "Metabolic regulation": {
      "eligible": 6,
      "ood": 1
    }
  },
  "swap_note": "v2b: swapped Belinostat (TRAIN->OOD) with SRT1720 (OOD->TRAIN). Both Epigenetic regulation stratum; iter169 plan named SRT2104 but that drug is in TRAIN under v2. Motivation: restore belinostat OOD to match the wet-lab narrative (MCF7 qPCR + microscopy)."
}