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"patient_demographics": {
"patient_id": "ANODE-ONC-75270",
"age": 80,
"gender": "Female",
"ethnicity": "Hispanic"
},
"clinical_oncology_profile": {
"primary_diagnosis": "Infiltrating Ductal Carcinoma (Breast Cancer)",
"stage_at_presentation": "T2N0M0 (Stage IIA)",
"histological_grade": "Grade 1 (Well Differentiated)",
"biomarker_status": {
"ER": "Positive (60%)",
"PR": "Positive (75%)",
"HER2": "Negative (1+ by IHC)"
}
},
"genomic_sequencing_data": {
"sequencing_type": "Targeted Next-Generation Sequencing (NGS)",
"somatic_variants_detected": [
{
"gene": "PIK3CA",
"alteration": "p.E545K",
"variant_allele_frequency_vaf": 0.46
},
{
"gene": "ESR1",
"alteration": "p.D538G",
"variant_allele_frequency_vaf": 0.23
},
{
"gene": "TP53",
"alteration": "p.R273H",
"variant_allele_frequency_vaf": 0.42
}
]
},
"longitudinal_treatment_ehr": {
"line_of_therapy": 1,
"regimen_administered": "Palbociclib + Letrozole",
"cycles_completed": 7,
"adverse_events_ctcae_v5": [
{
"toxicity": "Fatigue",
"grade": 3,
"action_taken": "Supportive care"
}
],
"treatment_response_recist_1_1": "Complete Response (CR)",
"progression_free_survival_months": 50.0
}
} |