{
  "patient_demographics": {
    "patient_id": "ANODE-ONC-75270",
    "age": 80,
    "gender": "Female",
    "ethnicity": "Hispanic"
  },
  "clinical_oncology_profile": {
    "primary_diagnosis": "Infiltrating Ductal Carcinoma (Breast Cancer)",
    "stage_at_presentation": "T2N0M0 (Stage IIA)",
    "histological_grade": "Grade 1 (Well Differentiated)",
    "biomarker_status": {
      "ER": "Positive (60%)",
      "PR": "Positive (75%)",
      "HER2": "Negative (1+ by IHC)"
    }
  },
  "genomic_sequencing_data": {
    "sequencing_type": "Targeted Next-Generation Sequencing (NGS)",
    "somatic_variants_detected": [
      {
        "gene": "PIK3CA",
        "alteration": "p.E545K",
        "variant_allele_frequency_vaf": 0.46
      },
      {
        "gene": "ESR1",
        "alteration": "p.D538G",
        "variant_allele_frequency_vaf": 0.23
      },
      {
        "gene": "TP53",
        "alteration": "p.R273H",
        "variant_allele_frequency_vaf": 0.42
      }
    ]
  },
  "longitudinal_treatment_ehr": {
    "line_of_therapy": 1,
    "regimen_administered": "Palbociclib + Letrozole",
    "cycles_completed": 7,
    "adverse_events_ctcae_v5": [
      {
        "toxicity": "Fatigue",
        "grade": 3,
        "action_taken": "Supportive care"
      }
    ],
    "treatment_response_recist_1_1": "Complete Response (CR)",
    "progression_free_survival_months": 50.0
  }
}