Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


Solitary firm nodule with central ulceration over left parietal region and bluish red indurated plaques in the retro-auricular regions.


Eyelid edema with indurated plaques over both eyes.


Dermis showed an ill-defined tumor composed of anastomosing infiltrative vascular channels lined by crowded variably plump and atypical endothelial cells. The mitotic figures are 32 per 10 hpf. The lumen showed presence of RBCs.


Magnetic resonance imaging scan showing hyperintense cystic lesion.


Cut surface of the tumor showing cystic degeneration.


Immunohistochemistry pictures showing cytoplasmic S-100 positivity (IHC, S-100, x100).


Immunohistochemistry (IHC) showing KI67 negativity (IHC, KI67, x100).


Histopathological findings. A; Immunohistochemical staining. The spindle tumor cells show a positive reaction for S100 protein.


Histopathological findings. B; A cuff-like lymphoid aggregate was recognized around the tumor.


Contrast-enhanced CT scan of the abdomen showing a huge right-sided retroperitoneal mass in front of the right kidney.


A histopathological picture of the retroperitoneal schwannoma.


Contrast-enhanced MRI after the first operation showing a left-sided VS.


Chordoid glioma in 34-year-old man. . A. Axial unenhanced CT showing hyperattenuated mass compressing frontal horn of right lateral ventricle. Note small calcification (arrow) in periphery of mass.


Chordoid glioma in 34-year-old man. B. Sagittal T1-weighted (upper left panel) and axial T2-weighted (upper central panel) images showing isointense lobulated mass (arrows) relative to cerebral cortex in anterior third ventricle. Axial susceptibility-weighted image (upper right panel) showing no evidence of intratumoral hemorrhage. Sagittal (lower left panel), axial (lower central panel), and coronal (lower right panel) post-contrast T1-weighted images showing strong enhancing main tumor with lobulated margin (arrows) in anterior part of third ventricle and smaller enhancing masses (arrowheads) along wall of lateral ventricles and fourth ventricle.


Chordoid glioma in 34-year-old man. C. CBV map of perfusion MRI showing elevated CBV within tumor (arrows) in third ventricle.


Chordoid glioma in 34-year-old man. D. Photomicrograph of hematoxylin and eosin stained slide showing solid cellular components composed of clusters and cords of epithelioid tumor cells (arrows) within variable mucinous stroma (original magnification x 400).


Chordoid glioma in 34-year-old man. Photomicrographs of immunostained slides for GFAP.


Chordoid glioma in 34-year-old man. CBV = cerebral blood volume E, F. CD 34. Showing diffuse and strong expression in tumor cells (dark yellow and brown colors) (original magnification x 400). GFAP = glial-fibrillary acid protein.


Tufted hair folliculitis on the scalp, a patch of alopecia characterized by perifollicular erythema and follicular hyperkeratosis.


The patient showed clinodactyly of the fifth finger of both hands.


More evidently on the left side, confirmed by X-ray examination.


Direct stool wet mount showing non-bile stained egg of Hymenolepis nana.


Direct stool wet mount showing the adult worm of Hymenolepis nana. The adult worm revealing the rostellum (black arrow), scolex (red arrow), and broader than long segments (yellow arrow).


Cut section of the excised tumor reveals a fleshy mass with areas of hemorrhage and necrosis.


Immunohistochemical profile shows.


Focal positivity for pancytokeratin.


More reactivity for epithelial membrane antibody. CD34 highlights the hemangiopericytomatous pattern of the blood vessels with the negative reaction of the tumor cells.


(d) Tumor cells show diffuse nuclear positivity for transducer-like enhancer of split - 1 (DAB, x200).


Preoperative appearance of breast mass. Image of the breast lesion illustrating the superolateral fungating breast ulcer on a large, irregularly shaped, nodular breast mass.


Examination findings. 2A: an anterior image of the patient illustrating the limb deformity confined to the right side of the body with limb shortening and irregular angular deformity. 2B: a lateral image of the patient illustrating limb abnormalities. 2C: Image of the patient's right hand illustrating nodular prominences of the bones of the hand and fingers as well as finger shortening and irregular angular deformity.


Cellular smears containing pleomorphic cells having very large nuclei (monster cells) with scanty cytoplasm. Few of the nuclei revealing nucleoli (Giemsa, x400).


Lesional cells revealed positive staining for vimentin (IHC, x200).


CECT abdomen showing mass replacing the right ovary with nonvisualization of the uterus.


(a) Microphotograph showing islands of large polygonal tumor cells surrounded by lymphoid cells. The tumor cells possess clear cytoplasm and centrally placed nuclei with vesicular chromatin and prominent nucleoli.


(H&E 400x) and (b) Microphotograph showing tumor cells arranged in papillary fronds having vesicular coffee bean nuclei. (H&E 100x).


Radiological evaluation of CG postoperatively. Post-contrast MRI images of the residual tumor 1 month (a,b).


Radiological evaluation of CG postoperatively. The size of the residual tumor decreased following GKRS (c-f).


Preoperative photograph showing diffuse swelling on the right side of infraorbital region without obliteration of nasolabial fold.


Intraoral photograph showing minimal or no swelling in the intraoral region.


Intraoperative photograph showing spillage of keratin material during incision.


Intraoperative photograph showing the enucleated cystic lining mass from the right maxillary sinus.


Intraoperative photograph after enucleation/curettage showing a large bony defect.


Gross specimen of the enucleated cyst.


The subretinal larva in the inferotemporal quadrant.


The subretinal larva after application of focal photocoagulation laser on and around the larval body.


Appearance of the patient at the time of presentation.


Maggots in the maxillary anterior region.


Removal of maggots with a tweezer.


Healing of the tissues after removal of larvae.


(a) T1-weighted contrast-enhanced image showing variegated contrast uptake by the tumor.


(b) Sagittal section showing pontine tumor completely occluding the fourth ventricle.


(c) Photomicrograph showing psammoma body like micro-calcification in tumor (Hematoxylin and Eosin, x200).


(d) Photomicrograph showing nuclear Ki67 labeling in the tumor cells (Ki67 immunostain, x400).


Axial T1 contrast-enhanced MRI (44 days after headache) and DWI (30 days after headache) through the point at which the oculomotor nerve emerges from the midbrain in this patient with left oculomotor ophthalmoplegic migraine. (A-C) Acute phase. The MRI shows a nodular, enhancing lesion in the cisternal segment of the left third nerve (arrow) in (A).


Axial T1 contrast-enhanced MRI (44 days after headache) and DWI (30 days after headache) through the point at which the oculomotor nerve emerges from the midbrain in this patient with left oculomotor ophthalmoplegic migraine. (A-C) Acute phase. In (B,C), a signal was demonstrated at the midbrain of the left-sided third cranial nerve on DWI and ADC.


Axial T1 contrast-enhanced MRI (44 days after headache) and DWI (30 days after headache) through the point at which the oculomotor nerve emerges from the midbrain in this patient with left oculomotor ophthalmoplegic migraine. (D-F) Quiescent phase, taken 7 weeks after the left ptosis and diplopia had resolved. (D) Demonstrates the decreased enhancement.


Axial T1 contrast-enhanced MRI (44 days after headache) and DWI (30 days after headache) through the point at which the oculomotor nerve emerges from the midbrain in this patient with left oculomotor ophthalmoplegic migraine. (D-F) Quiescent phase, taken 7 weeks after the left ptosis and diplopia had resolved. (E,F) Demonstrate that the signal had disappeared at this point on DWI and ADC.


Clinical manifestation and histopathological findings of porokeratosis ptychotropica. (A) Clinical manifestation shows "Butterfly shaped" verrucous plaque over buttocks with multiple satellite papules.


Clinical manifestation and histopathological findings of porokeratosis ptychotropica. (B) Histopathological findings shows characteristic multiple cornoid lamellae. Dyskeratotic cells and focal hypogranulosis were present in the epidermis underlying the column of parakeratosis (H&E staining, x200).


Erythema nodosum with bilateral eruption of painful subcutaneous nodules with overlying inflammatory redness. Involvement of only the upper extremities is unusual.


Two months after the initial skin eruption. Clinical examination revealed only residual discoloration and slight induration.


Case 1 CT image.


Case 2 CT image.


Magnetic resonance imaging of the left brachial plexus demonstrating a heterogeneous T1-hyperintense.


Homogeneously enhancing. Well-circumscribed lesion located in the posterior brachial plexus (white arrows).


Magnetic resonance imaging of the brachial plexus demonstrating a T1-isointense.


Avidly enhancing. Soft tissue mass along the left C7/T1 and T1/T2 neuroforamina (white arrows).


Erythroderma and pustulosis of our patient at the first day of hospitalization.


Pre- and postoperative funduscopy images in the right eye of case 1. Bullous rhegmatogenous retinal detachment developed from the upper quadrants (a).


Pre- and postoperative funduscopy images in the right eye of case 1. Following scleral buckling surgery, the retina was well reattached and corrected visual acuity improved from 0.01 to 0.6 (b).


Pre- and postoperative funduscopy images in the right eye of case 2. Bullous rhegmatogenous retinal detachment developed from the temporal two quadrants (a).


Pre- and postoperative funduscopy images in the right eye of case 2. Following scleral buckling surgery, the retina was well reattached and corrected visual acuity improved from 0.4 to 0.9 (b).


Funduscopy images of case 3. Preoperative.


Funduscopy images of case 3. Postoperative. Funduscopy images of the patient's right eye. Retinal detachment developed from the upper temporal quadrants. Following scleral buckling surgery, the retina was reattached; however, localized downward redetachment occurred and epiretinal membrane formation in the macula also developed at a late stage. Thus, vitreous surgery was then performed. Following surgery, the retina was reattached and corrected visual acuity improved to 0.7.


Chest CT in case 1 after chemo- and radiotherapy treatment. After 1 year of treatment, the patient showed a complete remission of the disease.


A) The fundus photo shows the sharply defined small pigmented lesion.


B) The fluorescein angiogram showed. Block fluorescence at the area of pigmentation and window defect at the marginal depigmentation.


Verrucous lesion on the chest.


Multiple, brownish pigmented, scaly lesions over the right arm, elbow and proximal forearm.


Nephrectomy specimen after longitudinal incision.


Axial brain CT demonstrates left gyriform calcifications as well as bilateral cerebral atrophy and dilatation of both lateral ventricles that is more prominent on the left side.


Coronal brain MRI (T1 with contrast) demonstrates a dura-based mass in the left parasagittal posterior parietal region, with enhancement and surrounding vasogenic edema.


Coronal brain MRI (T1 with contrast) shows post-operative changes after resection of the meningioma. It also demonstrates asymmetrical dilatation of the lateral ventricles.


Left face lesions due to nevus sebaceous.


Left frontotemporal lipoma.


Fourteen-days-old neonate with congenital melanocytic nevus on face.


Three months infant following surgical curettage and dermabrasion.


Protective metallic barrier as eye shield for laser surgery on table.


Outcome at 1 year of age.


Case 1. Axial T1-weighted.


Axial T2-weighted.


Coronal fluid-attenuated inversion recovery reveal a well-demarcated lobulated mass in the right temporal region causing bone erosion. It has an intracranial component and is hypointense on T1 and heterogeneously hyperintense on T2 and fluid-attenuated inversion recovery images.


Appearance of the wounds on the 2nd post-operative day. (A) Sternal incision.


Appearance of the wounds on the 2nd post-operative day. (B) Saphenous incision.


Necrosis in the superficial layer, infiltration of the dermis with interstitial lymphocytes, plasmocytes and neutrophils, and intradermal abscess formation (20 x 10, hematoxylin and eosin staining).


Recovery of the sternal wound on the 20th day of the treatment.


Lateral post-operative view of the right temporoparietal scalp.


Close-up view of Figure 1.


Low power micrograph of the lesion shows an extensive cystic component.


High power image of a solid area shows basaloid cells typical of poroma and occasional ductal structures (top right corner). The cells are uniform and cytologically bland. No mitotic figures are seen.


Cutaneous tuberculosis: fagedenic perianal ulcer.


Lepromatous leprosy: erythematous papules and nodules on the upper limbs.


Histopathological exam of the perianal ulcer showing a dense histiocytic infiltrate and central caseous necrosis.


Skin nodule consisting of foamy macrophages with globi of bacilli. Fite-Faraco staining revealed the presence of lepromatous leprosy acid-fast bacilli.


Cutaneous tuberculosis: phagedenic perianal ulcer showing worsening of the perianal ulcer after treatment for leprosy lesion, for two months.


M. tuberculosis,
positive culture on Lowenstein-Jensen medium at 37 C.


M. leprae
, positive polymerase chain reaction DNA analysis.


Perianal ulcer completely healed with antituberculous treatment for two months.


Clinical picture of the patient. Elevated, keloid-like, fine nodules coalescing into diffuse sclerodermoid plaques in a background of erythema were found on the right upper arm, chest wall, and abdomen.


(A). Macroscopic view of skin-colored compressible protuberances in the cervical neck region simulating a lipoma (Blue arrow).


(B) Macroscopic view of the left side of the chest showing small, dark-blue venous nodules (Blue arrow).


(C,D) Axial gradient echo images, multiple lesions shown by red arrows.


X-rays of both wrists.


Magnetic resonance imaging of the wrist showing the ulnocarpal conflict with the related overpressure cysts.


Otitis externa of Ian, a 10 years old male Samoyed dog.


Cytotoxic activities of PVA/Ag Nps on MDCK cell line at 24h and 48h.


5-year-old boy diagnosed case of dystrophic epidermolysis bullosa, immediately after induction of anesthesia.


5-year-old boy diagnosed case of dystrophic epidermolysis bullosa. Postoperatively after plastic surgical repair in post-anesthesia care unit.


Radiograph of multiple odontogenic keratocysts around upper incisive as lytic lesions.


Calcified ovarian masses are marked in CT-scan.


Microscopic appearance of fibroma showing benign spindle cells (Hematoxylin and Eosin staining*400).


Microscopic appearance of fibroma showing calcified foci (Hematoxylin and Eosin staining*100).


Paraffin-embedded tissue samples from the abdomen. Were deparaffinized and stained with anti-periostin antibody Original magnification: x100.


The right knee. Were deparaffinized and stained with anti-periostin antibody Original magnification: x100.


Paraffin-embedded tissue samples from the abdomen , anti-MMP-7 antibody , x200.


The right knee , anti-MMP-7 antibody , x200.


Paraffin-embedded tissue samples from the abdomen , anti-MMP-28 antibody , x200.


The right knee , anti-MMP-28 antibody , x200.


Paraffin-embedded tissue samples from the abdomen , anti-CD163 antibody , x200.


The right knee , anti-CD163 antibody Original magnification: x100.


Paraffin-embedded tissue samples from the abdomen. Or anti-CD206 antibody The sections were developed with liquid permanent red. , x200.


The right knee. Or anti-CD206 antibody The sections were developed with liquid permanent red. Original magnification: x100.


Multiple tense bullae-clinical aspect of bullous pemphigoid.


Erythematous plaques covered with tense blisters with clear fluid-clinical aspect of bullous pemphigoid.


Erythematous scaly plaques-clinical aspect of psoriasis vulgaris.


Atrophic epidermis with sub-epidermal blister containing numerous eosinophils and neutrophils, col. HE x 40.


Atrophic epidermis with sub-epidermal blister containing numerous eosinophils and neutrophils, col. HE x 100.


Atrophic epidermis with sub-epidermal blister containing numerous eosinophils and neutrophils, col. HE x 200.


FNAC before RFA. 4 microm-thick H&E stained sections from the cell-block show a highly cellular sample, with a typical papillary architecture; thyrocytes show irregular, large and clear nuclei. A diagnosis of Papillary Thyroid Carcinoma (TIR5 according to the Italian SIAPEC-IAP classification of thyroid cytology) was formulated. Magnification x200.


FNAC before RFA. 4 microm-thick H&E stained sections from the cell-block show a highly cellular sample, with a typical papillary architecture; thyrocytes show irregular, large and clear nuclei. . X400).


Ultrasound features of the nodule before and after RFA. Before RFA (A), the nodulation has a solid, irregular, hypoechoic structure, with slightly spiculated margins and microcalcifications.


Ultrasound features of the nodule before and after RFA. At control 12 months after RFA only a small nodular, hypoechoic and homogeneous area is appreciable (B); it is in contact with the thyroid capsule that appears slightly retracted but with no signs of extra-thyroidal extension.


FNAC after RFA H&E.


Or Giemsa. Stained smears.


H&E stained section from cell-block. Exhibit a poorly cellular sample with sparse inflammatory elements or multinucleated giant cells in a background of thick colloid and fibrosis (magnification x400).


Eruption of pustules with scaling, tender swelling over fingers of both hands in a patient with psoriatic arthritis.


Right foot medial fifth digit with granulomatous mass.


Right foot fifth digit partial thickness wound with sloughed granulomatous mass.


Right foot fifth digit with two distinct cyanotic papules.


Histopathology hematoxylin and eosin stain with magnification 200X showing spindle cell proliferation and slit-like vascular spaces.


Proliferated spindle cells demonstrate positive staining (brown) of the antibody to HHV-8.


The view of the 28 x 25 cm sacral defect before debridement. It was treated with gluteus maximus myocutaneous flap from the left gluteal area following sacrectomy. Postoperative suture detachment in the midline yielded the large defect with radionecrosis.


The omentum flap based on the right gastroepiploic artery was raised.


The omentum was passed through the Petit triangle and adapted to the sacral defect.


Postoperative result of the omentum flap 1 year after reconstruction of the lumbosacral area.


Rapid SCORAD improvement and corticosteroid tapering in regards to Omalizumab therapy.


Bony hard swelling causing obliteration of the vestibule of left side of mandible, extending from the right deciduous lateral incisor to the left deciduous second molar region.


A) The CT revealed a well-defined multilocular radiolucent lesion extending from the lower right deciduous lateral incisor to the right deciduous second molar region.


B) Bucco-lingual expansion, perforation and thinning of the buccal plate were observed. The lesion also showed small calcified areas.


C) Multiple impacted permanent teeth were noted.


A) Multiple follicles of proliferating odontogenic epithelium with the surrounding primitive ectomesenchyme showed increased cellularity simulating the dental papillae.


B) Areas showing dentin formation and enamel spaces (hematoxylin-eosin, original magnification 100x).


C, D) Areas with cartilage formation were also observed. These areas exhibited increased maturation as they progressed further away from the epithelial follicles, showing hypercellularity and some binucleated cells (hematoxylin-eosin, original magnification:. 200x.


C, D) Areas with cartilage formation were also observed. . 400x).


(a-c) Fundus and optical coherence tomography changes at 1st presentation.


Montaged fundus image at day 10, retinal pigment epithelial changes in the posterior pole and in the triangular wedge-shaped are.


(a and b) Day 23 and 3-month fundus photograph showing the segmental chorioretinal atrophic patch (triangular sign of Amalric).


Noncontrast head CT (a) demonstrating an ill-defined hypodense lesion in the right cerebellar hemisphere causing compression of the 4th ventricle.


Contrast-enhanced head CT (b) demonstrating an ill-defined, mildly enhancing right cerebellar lesion. The indistinct appearance of cystic structures can be appreciated surrounding the area of enhancement.