Color fundus photographs show (A) day 5 retinal whitening with scattered flame-shaped retinal hemorrhage, attenuated retinal arteries and venous dilatation representing combined central retinal artery and vein occlusion. There is optic disc swelling. The cilioretinal artery presenting with retinal whitening along the vessel demonstrates cilioretinal artery occlusion.


(B) Day 10 a week after treatment by canthotomy and cantholysis to relieve orbital pressure, optic disc swelling, retinal swelling and whitening decreases. However, there is obvious evidence of a macular hole.


Day 10 fundus photograph shows (A) retinal whitening and hemorrhage in the macular area with macular hole. Cilioretinal artery is occluded (star).


(B) Late phase of fluorescein angiography overlying on the fundus photograph reveals vascular filling defect of the arteries around the macula including cilioretinal branch (star).


Was more severe than the right eye.


External eye photography revealed bilateral corneal well-defined, elevated, whitish opaque lesions (OU), the left eye.


Under high-power magnification, the lesion had a glistening appearance without vascularization (c).


The anterior segment optical coherence tomography of the left eye revealed that the corneal lesion expressed a hyperplastic epithelium with Bowman's layer disruption, and mild edematous stroma, which had increased thickness and loss of normal lamellar appearance. The Descemet's membrane and endothelium were intact during this examination.


(A) Clinical characteristics of our patient at presentation, 3 and 7 months after therapy initiation.


(B) ngTIN in our patient, 20x magnification, hematoxylin and eosin (HE) stain.


(C) Course of treatment in our patient. D, day; w, week; m, months; MP, methylprednisolone; PRED, prednisolone; MTX, methotrexate.


Confocal microscopy images of the subbasal epithelial layer. The nerve fibers were not observed in the right eye.


Confocal microscopy images of the subbasal epithelial layer. But complete nerve fibers were observed in the left eye.


The operative findings and histopathology. (A) The tumor was located in the left cerebellar hemisphere and measured 4.5 cmx 4 cm.


The operative findings and histopathology. (B, C) Photomicrograph of hematoxylin and eosin staining showed that malignant tumor cells grew around the blood vessels or cavity, with typical Schiller-Duval bodies (red arrow). [Original magnifications:. 100x.


The operative findings and histopathology. (B, C) Photomicrograph of hematoxylin and eosin staining showed that malignant tumor cells grew around the blood vessels or cavity, with typical Schiller-Duval bodies (red arrow). 200x.


The operative findings and histopathology. (D) Photomicrograph of immunohistochemical staining revealed that the majority of the tumor cells were strongly positive for alpha-fetoprotein (AFP) in the cytoplasm. [Original magnifications:. 100x.


The operative findings and histopathology. (E) Photomicrograph of immunohistochemical staining suggested a positive reaction for Sal-like protein 4 (SALL-4) in the nucleus of the tumor cells. [Original magnifications:. 100x.


Radiological evaluation of YST post operation. CT scanning of the residual tumor on day 7 (A).


Radiological evaluation of YST post operation. And two weeks after operation (B). The size of the residual tumor significantly decreased. Patchy hyperdense shadow was seen in the left cerebellar hemisphere, surrounded by patchy low-density edema. No obvious abnormalities were found in the ventricle or cisterns. Displacement of middle structure was not found.


Meningeal biopsy in patient 1. Meningeal tissue section showing Abeta amyloid deposits in the wall of small meningeal arteries (brown staining) and a lymphocytic perivascular infiltrate (dark blue cells).


Ulcer measuring 10x8 cm with purulent exudate and undermined edge with overlying necrotic skin over left pretibial region.


Ulcer showing hypergranulation tissue with ragged edge over anterolateral aspect of left lower leg.


MRI showing altered signal around left sacroiliac joint.


MRI showing small fluid collection adjacent to right ischial tuberosity suggesting an infective etiology.


Brain imaging and immunohistochemical results. (A) Rapid progressive damage in the bilateral basal ganglia. Upper: Right basal ganglia lesion with patchy abnormal signals before admission. Lower: The bilateral basal ganglia showed patchy abnormal signals after admission. Bilateral basal ganglia lesions with hemorrhage on the right side.


Brain imaging and immunohistochemical results. (B) Mixed density shadow in the bilateral basal ganglia with peripheral parenchymal edema and postoperative resection of right basal ganglia lesions.


Brain imaging and immunohistochemical results. (C) Pathological results from the brain tissues of lesions in the right basal ganglia. Hematoxylin-eosin staining. Fungal spores and hyphae were observed in a small amount of necrotic brain tissue.


Fracture at graft site.


Medication use during treatment with omalizumab in patient 1. Red solid line Omalizumab injections; black solid line Prednisone intake; blue solid line Cetirizine intake; green solid line Ketotifen intake. Average doses of AH and oral glucocorticoids were calculated for every month in the past two and a half years.


Long-term therapy treatment of density of FcepsilonRI-receptors on basophils in patient 1. Red solid line Omalizumab injections; blue solid line FcepsilonRI-receptor density. Receptor density decreased substantially during treatment with omalizumab over 31 months from 74,051 receptors per cell before start of treatment, to 1,907 receptors per cell.


FA of the LE at presentation, showing impregnation but not diffusion.


Image showing a clinical picture of the right shoulder with massive swelling demonstrating fluctuation. Clinical image of the right shoulder showing a massive dumbbell-shaped swelling, soft in consistency with positive fluctuation.


Image showing lateral aspect of the right shoulder with dumbbell-shaped swelling. Clinical image of the right shoulder showing lateral aspect of dumbbell-shaped swelling.


Image showing posterior aspect of the right arm. Clinical image of the right shoulder showing posterior aspect of dumbbell-shaped swelling.


Anteroposterior radiograph of the right shoulder at the time of presentation. Plain radiograph of the right shoulder anteroposterior view shows erosion of the glenoid cavity and head of the humerus with a reduction in the joint space. Obliteration of adjacent fat planes is seen with minimal erosion of lateral end of clavicle.


Chest radiograph showing miliary changes in both the lung fields. Plain posteroanterior radiograph of chest showing widespread small nodular opacities distributed throughout the lung fields suggestive of miliary tuberculosis (past history).


Magnetic resonance imaging T2-weighted coronal section. Magnetic resonance imaging of the right shoulder T2-weighted coronal cut showing cortical erosions involving articular margins of humeral head and bony glenoid. There are moderate joint effusion and synovial thickening with a large loculated periarticular collection extending to supraspinatus fossa and upper arm along with the deltoid muscle.


Magnetic resonance imaging T2-weighted axial section of the right humerus. Magnetic resonance imaging of the right shoulder T2-weighted axial cut showing a large bilocular collection around right humerus with soft-tissue edema.


Final clinical picture of the right shoulder after three sessions of aspiration and injection and 1 year of anti-tubercular therapy. Clinical picture of the right shoulder and arm at 1-year follow-up after complete ATT and three sessions of aspiration and injection streptomycin.


Plain radiograph of the right shoulder at 1-year follow-up shows healing with sclerosis at proximal humerus and superior migration of humeral head. There were no changes in the glenoid cavity with a resolution of previous osteolytic lesions rendering the glenohumeral joint in incongruous congruity.


Capsule endoscopy image. To evaluate small bowel involvement, capsule endoscopy was performed, showing multiple deep ulcers. In this picture the border of a long, deep ileal ulcer is shown (asterisk), with elevated, hyperemic borders (arrow).


Ileoscopy image. The presence of an ileal pouch allowed deep ileoscopy using a colonoscope, and multiple biopsies were taken from ileal ulcers (arrow) and the surrounding mucosa for histological analysis. This image shows an 8-mm-long, clean-based ileal ulcer.


Multimodal imaging of the right eye at the first presentation. Infrared reflectance, and ,optical coherence tomography (OCT) of the macula.


Multimodal imaging of the right eye at the first presentation. Fundus photograph show a large pigment epithelial detachment (PED) at the macula with surrounding small and intermediate drusen. There was a small satellite PED which coalesced into a single large PED 6 days later.


Multimodal imaging of the right eye at the first presentation. (c) Enhanced-depth imaging OCT scan through the foveal center shows a large PED with serous subretinal fluid at its apex.


Evolution of the pigment epithelial detachment (PED) and subretinal fluid (SRF) of the patient. (a) Baseline enhance-depth imaging optical coherence tomography.


Evolution of the pigment epithelial detachment (PED) and subretinal fluid (SRF) of the patient. (b) 1 month after the first intravitreal injection (bevacizumab), the PED was partially resolved, but SRF increased.


Evolution of the pigment epithelial detachment (PED) and subretinal fluid (SRF) of the patient. (c) 1 month after the second injection (aflibercept), partial resolution of both PED and SRF is shown.


Evolution of the pigment epithelial detachment (PED) and subretinal fluid (SRF) of the patient. (d) 1 month after the third injection (aflibercept), both PED and SRF were completely resolved. The patient's visual acuity improved to 20/30.


Multimodal imaging of the right eye at the first relapse of the pigment epithelial detachment (PED). Fundus photograph.


Multimodal imaging of the right eye at the first relapse of the pigment epithelial detachment (PED). Infrared image.


Multimodal imaging of the right eye at the first relapse of the pigment epithelial detachment (PED). Enhance-depth imaging optical coherence tomography show a relapse of shallow serous PED without subretinal fluid.


Multimodal imaging of the right eye at the first relapse of the pigment epithelial detachment (PED). (d) Fundus fluorescein angiography demonstrates the pooling of the PED beginning at the inferotemporal area.


Multimodal imaging of the right eye at the first relapse of the pigment epithelial detachment (PED). (e) Indocyanine green angiography shows hypocyanescence blockage of the PED. No abnormal hypercyanescence plaque of choroidal neovascularization was identified. The choroidal hyperpermeability was less intense than at the baseline visit.


Enhanced-depth imaging optical coherence tomography shows relapses of the (PED). (a) 7 days after receiving 8 mg intravenous dexamethasone, the second relapse of the large PED is shown.


Enhanced-depth imaging optical coherence tomography shows relapses of the (PED). (b) After 1 month of observation, subretinal fluid (SRF) developed.


Enhanced-depth imaging optical coherence tomography shows relapses of the (PED). (c) After receiving the fifth intravitreal aflibercept injection, PED and SRF completely disappeared.


Enhanced-depth imaging optical coherence tomography shows relapses of the (PED). (d) 4 months after the last injection, a shallow PED recurred but was spontaneously resolved.


Enhanced-depth imaging optical coherence tomography shows relapses of the (PED). 7 months.


Enhanced-depth imaging optical coherence tomography shows relapses of the (PED). 11 months.


Enhanced-depth imaging optical coherence tomography shows relapses of the (PED). 22 months after the last injection, there were no further recurrences of the disease.


Waxy papular lesions over the trunk and back.


Leonine facies and exaggeration of facial ridges.


Doughnut sign on the metacarpophalangeal joints.


Alcian blue stain highlights markedly increased dermal mucin (Alcian blue, x20).


Colonoscopy. . About 4cm sized submucosal tumor was identified at the sigmoid colon.


Abdominopelvic computerized tomography (CT). . A well-circumscribed, well-enhanced, round-shaped mass was identified at the sigmoid colon. (
A) Coronal view.


Abdominopelvic computerized tomography (CT). . A well-circumscribed, well-enhanced, round-shaped mass was identified at the sigmoid colon. (
B) Axial view.


Gross findings of the resected specimen. . (
A) 4.5 x 4.0cm sized round, protruding mass was observed on the surface of the serosa.


Gross findings of the resected specimen. (
B) The photo was taken from the mucosal side.


Cut section after fixation. . Relatively well-demarcated yellowish mass without encapsulation is shown.


Hematoxylin and eosin (H&E) stain. . (
A) The tumor cells are composed of spindle cells with low nuclear atypia.


Hematoxylin and eosin (H&E) stain. (
B) Nuclear palisading growth pattern is shown.


Hematoxylin and eosin (H&E) stain. (
C) Lymphoid cuffing surrounding tumor cells is shown.


Immunohistochemical stain. . (
A) S-100 is diffuse, strong positive in tumor cells.


Immunohistochemical stain. (
C) CD34 is negative in tumor cell, but normal vessel structures were stained.


Immunohistochemical stain. (
D) SMA is negative in tumor cells, but normal smooth muscle in the proper muscle layer is stained.


Extensive erythematous, vesicular and pustular skin lesions associated with bleeding and adherent crusts noted over face particularly over the forehead, nose and peri-oral regions.


Disrupted vesicles causing bleeding and crusting.


Lund and Browder chart.


Patient's hands after two weeks of treatment. Note: The picture baseline was taken on the fifth day of antibiotic treatment when two blood culture reports revealed growth of Aerococcus viridians but not at the initial presentation when cutaneous vasculitis was prominent.


H & E stain of 10X view showing tumour cells arranged in alveolar pattern separated by fibrovascular stroma.


H & E stain 40x view showing Two distinctive types of cells - large cells arranged peripherally with abundant cytoplasm, round vesicular nucleus and brown pigment; and small cells with scanty cytoplasm and hyperchromatic round nuclei were seen in the center.


IHC Stain Cytokeratin.


IHC stain HMB45.


IHC Stain NSE.


IHC Stain Synaptophysin.


Blisters of oral mucosa.


Periodontal status of patient showing extensive calculus deposition and generalized gingival inflammation.


Orthopantomogram of patient showing generalized extensive horizontal bone loss with some areas having vertical defects.


Dermal manifestations of patient showing cigarette paper like appearance of skin.


Histopathology of skin biopsy showing subepithelial cleft.


(a) The appearence of swelling, approximately 2x2 cm, in the frontal area.


(b) The mass eroding the left frontal sinus anterior wall on paranasal sinus tomography.


(a) Shows intraoperative image of craniectomy with good margins (large arrows). There is no involvement of the dura mater (thin arrow).


(b) Shows the resected cranial defect.


Gross and radiology of Case 2.


Hemorrhagic crust, scaly erosion on the lips, and generalized erythroderma with some foci of atypical target lesions on the face, trunk, and upper extremities (a, b).


Superficial perivascular infiltration (predominately consisting of lymphocytes and eosinophils), mild epidermal hyperplasia, basal vacuolization, exocytosis, scattered necrotic keratinocytes, and prominent melanophages. Hematoxylin-eosin, original magnification x400.


Direct immunofluorescent study showed intercellular deposition of IgG resembling chicken wire feature and linear basement membrane zone staining with IgG.


Medical image.


The fundus photo of the left eye in 2013, 6 months after the single intravitreal injection of ranibizumab, shows decreased vascularization of the hemangioma and mild fibrosis.


The salivary gland lobules showed epithelioid, and ,multinucleated giant cell granulomas (H&E.


X40). Focal necrosis was observed (H&E, x40).


Scleromyxedema: nodular lesions on the face.


Papular mucinosis on the neck.


Complete regression of nodular lesions on the face.


(a) Cardiac MRI of the patient with cine RV-2 chamber view showing the pericardial mass encasing the right atrioventricular groove (AV) groove (solid red arrow). Labelled RA: Right atrium; RV: Right ventricle; IVC: Inferior vena cava.


(b) Tissue characteristics of the right atrial mass.


Computed tomography scan showing mediastinal lymphadenopath.


Slide of laryngeal papilloma.


Slide of squamous carcinoma.


Multiple pustular and crusted lesions on the trunk.


Extremities. On the day of admission.


Bone marrow aspirate smear (from bone marrow biopsy) stained with May-Grunwald Giemsa showing amastigote forms of Leishmania spp.


Viral load and CD4+ T-cells count evolution following cART initiation and VL diagnosis. TRIP = travel in Greece; H = date of hospitalization; (c)ART = (combined) anti-retroviral therapy; BMB = bone marrow biopsy (VL diagnosis); M1 = first month after cART initiation; M3 = third month after cART initiation; M6 = sixth month after cART initiation; LAmB = intravenous liposomal amphotericin B administrations.


A; CT scan with contrast of abdomen showed a large, heterogenously enhancing mid to distal pancreatic mass measuring 9.4 x 3.8 cm with surrounding low-attenuation soft tissue thickening (white arrows).


A biopsy of skin lesion showing psoriasiform inflammatory reaction and confluent parakeratosis.


Intraoperative view of the tumour. Patient after the second surgical debridement procedure. The defect involves the scrotum, the perineum, the right ischial region and extended to the lower abdomen.


Post-operative 21 days later surgery. The healthy granulation tissue throughout wound.


Intraoperative view following Integra application. Surgical application of dermal regenerative template.


Post-operative final result at 18 months. Patient showed a satisfying functional and aesthetic result.


Photomicrograph showing first instar larva of Oestrus ovis (x150).


Second nerve conduction study according to standard techniques performed on day 25 after admission. No F-waves are recorded by supramaximal stimulation of right ulnar nerve at wrist; M waves are within normal range.


Contrast-enhanced magnetic resonance image showing fungal rhinosinusitis, along with proptosis of the right eye.


The patient had a 10 cm x 5 cm cavity with a 10-cm-long fistula into the axilla when referred to our department.


A LD-flap was raised to cover the region of the excised fistula.


The fistula recurred (arrow) despite the transferred LD-flap.


Lymphangiography shows lymph vessels emptying into multiple cavities in the axilla and the lateral thoracic wall.


Two lymphatic vessels from the thigh are ready for transplantation.


Lymphoscintigraphy, performed 11 years after grafting clearly shows lymph flow along the route of patent lymphatic grafts from the left arm to the neck (arrows). Left, frontal view; right, dorsal view.


A; Multiple scaly erythematous alopecic plaques on the frontal and both parietal regions of the scalp.


B; Dermoscopic examination (x20) showed decreased hair density, increased vellus hair follicles, diffuse white scales, and patchy dotted vessels (red circles).


Histopathologic findings included superficial perivascular infiltration mainly composed of neutrophils, psoriasiform epidermal hyperplasia, parakeratosis, decreased number of terminal hair, and sebaceous gland atrophy (HE, x40).


A; Significant improvement in terms of decreased scalp inflammation and stabilization of hair loss after 3 weeks of treatment.


B; The patient achieved 75% hair regrowth at 3 months after treatment.


OPG revealing odontogenic keratocyst in the right mandible and lateral periodontal cyst in the left mandible.


Surgical enucleation of the odontogenic keratocyst.


(a and b) Surgical enucleation of lateral periodontal cyst.


A-C
) Positron emission tomography-computed tomography (PET CT) was performed, which demonstrated increased fluoro-2-deoxy-d-glucose uptake in both masses (standardized uptake value of 7.3 for the larger mass and 2.7 for the smaller mass).


Magnetic resonance imaging (MRI) neurogram demonstrated a larger 4.6 x 3.2 x 2.5 cm mass deep to the left sternocleidomastoid muscle just below the angle of the mandible.


A bilobed 2.4 x 2.2 x 1.3 cm mass in the left posterior supraclavicular region.


No recordable visual evoked potentials (VEPs; N75, P100, and N145) and VEP waveforms are seen.


The denaturing high-performance liquid chromatography analysis results show a full deletion of exon 4 in the ARSA gene.


Facial Profile of the patient.


Extension of the lesion.


Computed tomography of the chest: (A) A large fibroelastoma (red arrow) in the aortic bulb.


(B) Cross-section showing localization of fibroelastoma (red arrow) right next to the left coronary artery ostium. (AoB) Aortic bulb. (LV) Left ventricle. (LCA) Left coronary artery. (RCA) right coronary artery.


Surgical view after transverse aortotomy: (A) Fibroelastoma (blue arrow) localization in the Valsalva sinus.


(B) A tumor (blue arrow) was attached by a thin stalk (red arrow) between the right and left coronary aortic cusps at the aortic side. Notice normal anatomical preservation of the aortic valve leaflets. The left coronary cusp was hidden behind the tumor. (RCC) Right coronary cusp. (NCC) Noncoronary cusp. (LCC) Left coronary cusp.


Pathological exam of papillary fibroelastoma: (A) Gross specimen.


(B) Histological finding stained by hematoxylin-eosin method (a fragment from a tumor nodule constructed of numerous papillary formations lined with endothelial cells while a stromal papilla is constructed of a homogeneous, hypocellular portion of edematous connective tissue) on a low magnification.


Cervical spine imaging. Magnetic resonance imaging T1-sequence sagittal post-contrast demonstrates homogeneously enhancing, intradural-extramedullary ventrolateral mass.


Images were acquired 20 minutes after intravenous injection of NaTcO4. Planar image anterior view.


Images were acquired 20 minutes after intravenous injection of NaTcO4. Face turned to the right. Show 2 foci of tracer uptake in the upper part of the neck. No tracer uptake was noted in the expected location of orthotopic thyroid gland.


Images were acquired 20 minutes after intravenous injection of NaTcO4. And localized the ectopic thyroid tissues to the sub-hyoid location.


Images were acquired 20 minutes after intravenous injection of NaTcO4. And suprahyoid locations.


Longitudinal melanonychia in the nails of the feet.


Longitudinal melanonychia in the nails of the hands.


Skin biopsy showed increased melanin in the basal layer (H/E x200).


Histological section with haematoxylin and eosin staining, magnification, x200. Primarily round and spindle cells, were identified to contain eccentric nuclei and deeply eosinophilic cytoplasm.


Whole abdomen CT images show abdominal mass prior to treatment.


After 2 cycles of treatment.


After 4 cycles of treatment.


After the whole treatment (8 cycles).


Pseudosyndactyly and absent finger nails seen in the patient in the case report.


Alopecia and scabs on neck seen in the patient in the case report.


Limited mouth opening, ankyloglossia, retroclined lower anterior teeth seen in the patient in the case report.


Obliterated labial sulcus seen in the patient in the case report.


Lesion with hypersignal on T2 in the regions of midbrain and right parahippocampus.


Hyperintense lesion on T2 at the midbrain peduncle, mimicking a mesencephalic tumor.


Microphotograph showing clusters of round-to-oval cells (MGG, x100). Inset showing wisps of magenta-colored material (MGG, x400).


Microphotograph showing spindle-shaped endothelial cells (arrow) crossing a cluster of tumor cells (MGG, x400).


Histopathologic sections showing nests and sheets of tumor cells around endothelium-lined small blood vessels (Hand E, x100).


Resection of the frontal/parietal/temporal mass. Post-operative MRI contrasted T1 and T2 scans showed resection of the meningiomas in the left frontal/parietal/temporal convexity with expected post-operative changes (red arrows in A,C, not shown in B). The occipital lobe mass was visible from the sagittal view (white arrow in A).


Latest imaging. Her most recent MRIs (16 months after her last surgery) show multiple enhancing extra-axial masses, stable compared to her immediate post-operative MRIs. Here is a stable 1.8 cm (superior-inferior) meningioma arising from the left posterior falx, adjacent to the prior resection cavity (red arrows in A-C). No recurrence observed.


Absence of hair on face and scalp.


Absence of hair in axilla.


Multiple skin tags.


Case 1 irregular lip ulcerations with blood encrustations.


Case 1 irregular buccal mucosal and tongue ulcerations with lip lesions.


Case 1 after 10 days of treatment the oral mucosal and lip ulcerations are healed.


Case 2 palatal ulcerations with irregular blood encrusted lip lesions.


Case 2 after 10 days of treatment the healing palatal and healed lip ulcerations.


Two months postsurgery, the patient was followed up by chest CT and had no evidence of tumor recurrence.


Timeline of symptoms, investigation, and treatment.


Back of 50 year old female patient from Southwest Virginia showing erythema migrans "bulls-eye" the characteristic rash of Lyme disease. . Note: The rash had decreased to 11 cm x 14 cm by day 9 post infection following 4 full days of antibiotic treatment.


Back of 50 year old female patient from Southwest Virginia showing erythema migrans "bulls-eye" characteristic of Lyme disease. . Note: The rash had decreased from 16 x 19 cm. (black inked outer oval, pretreatment) to 11 cm x 14 cm. (bright reddened area, day 4 of treatment).


CT demonstrating retroesophageal SCA (black arrow) originating from aorta, medial to esophageal leiomyosarcoma (white arrow).


CT demonstrating isolated right pleural metastasis (white arrow).


Complex papillary structures having a central vascular core with large areas of necrosis.


Lining cells show stratification and multilayering with large oval nuclei and show numerous mitotic figures.


S-100 positivity.


Pan cytokeratin positivity.


GFAP positivity.


Clinical photograph of swelling.


(a) Intraoperative photograph showing extremely thinned out outer table of the occipital bone along with evidence of cerebrospinal fluid within the intradiploic space.


(b) Intraoperative photograph showing extremely thinned out inner table of the occipital bone (thinned outer table excised).


(c) Small linear defect of 1 cm x 5 mm was visualized in the inner table along with underlying dural defect through which cerebrospinal fluid was coming into the intradiploic space.


(a) Watertight repair of the dural defect was done using pericranium and then reinforced with fibrin glue.


(b) Reconstruction of defect in the outer table was done using Osteomesh.


(a and b) Magnetic resonance imaging cervical spine done at 6-month follow-up showed a significant reduction in the size of syrinx.


Purplish nodules on lower extremities.


Hemalun eosin, x50 magnification. The infiltrate occurred in fat lobules.


Clinical aspect of the mass evoking a tumor of Darier and Ferrand.


Magnetic resonance imaging noted a well limited, vascularized, round mass of cutaneous and subcutaneous tissues.


Resection of the tumor with a margin of excision of 5 cm involving in-depth the aponeurosis. The residual skin defect was grafted.


The esthetic and functional result was assessed as good at 5 year follow-up.


Erosive, atrophic, well-demarcated scaly erythema with on the patient's right palm.


Right sole.


Atypical large lymphocytes densely infiltrated mainly in the upper dermis with involvement of the overlying epidermis (a).


Paraffin-embedded tissue samples were deparaffinized and stained with anti-POSTN Original magnification: a x200, b-d x100.


Anti-CD206 antibodies The sections were developed with liquid permanent red.


A; Left renal arteriography confirmed an AVF with aneurysmal dilatation and an enlarged draining vein.


B; Superselective catheterization before embolization.


C; Occlusion of an AVF and aneurysmal dilatation after embolization.


D; Confirmation of no additional detection of perfusion after the procedure.


Follow-up MRI taken 3 months after the intervention. No abnormalities, including the dilatation of the renal vein, can be seen.


Family pedigree demonstrating affected individuals and consanguinity, favoring autosomal recessive inheritance.


Compact hyperkeratotic plaques and thick scales affecting the soles.


Scattered thick scales with ridging over the palms and flexor aspect of the upper limb.


Scattered thick scales with ridging over the dorsal aspect of the feet and lower extremities.


Erythematous patches and scattered scales over the trunk.


Prominent hyperkeratosis with irregular acanthosis and vacuolar degeneration of the granular and spinous layers . Original magnification.


Occasional keratohyalin bodies with minimal blistering overlying chronic inflammatory infiltrate , hematoxylin, and ,eosin stain,. X10:. X40.


Frontal, and ,lateral view face showing the frontal bossing, midface hypoplasia, and ,a relatively large mandible, shallow orbits, hypertelorism, exophthalmos, short, and ,incompetent upper lip, depressed nasal bridge.


Lateral view of the face.


Pseudocleft in the palate.


Intraoral view showing crowding of upper and lower teeth, reverse overjet with posterior crossbite and anterior open bite.


Three-dimensional CT scan of skull revealing surgically opened coronal sutures, frontal bossing, shallow orbits, hypoplastic maxilla, and ,zygoma.


Obliteration of sagittal and lambdoid sutures.


Anterior segment photograph of her right eye at presentation.


58-year-old man with a 12-month history of recurrent headaches diagnosed with PCLp associated with bilaterally symmetrical lateral ventricular CPLps without corpus callosal anomalies. Axial unenhanced CT scan of the head shows midline PCLp (white arrows) and left lateral ventricular CPLp (black arrow). The fat appears more hypodense than CSF.


58-year-old man with a 12-month history of recurrent headaches diagnosed with PCLp associated with bilaterally symmetrical lateral ventricular CPLps without corpus callosal anomalies. (a and b) Axial unenhanced CT scans of the head show PCLp with peripheral calcifications (white arrows) and PCLp continuing as bilaterally symmetrical CPLps (black arrows).


58-year-old man with a 12-month history of recurrent headaches diagnosed with PCLp associated with bilaterally symmetrical lateral ventricular CPLps without corpus callosal anomalies. Sagittal unenhanced FLAIR MRI scan shows PCLp (white arrows) and discrete areas of fatty tissue around the anterior interhemispheric fissure (black arrow). Also, evident is normal corpus callosum.


58-year-old man with a 12-month history of recurrent headaches diagnosed with PCLp associated with bilaterally symmetrical lateral ventricular CPLps without corpus callosal anomalies. (a and b) Coronal unenhanced T1 weighted MRI scans show PCLp (black arrows) continuing as bilaterally symmetrical lateral ventricular CPLps (white arrows).


58-year-old man with a 12-month history of recurrent headaches diagnosed with PCLp associated with bilaterally symmetrical lateral ventricular CPLps without corpus callosal anomalies. Axial unenhanced T1 weighted MRI scan shows PCLp (white arrow) and bilaterally symmetrical lateral ventricular CPLps (black arrows). Also note discrete areas of fatty tissue in the medial sulcus of the right frontal lobe (dashed arrow).


58-year-old gentleman complaining of recurrent headaches since twelve months diagnosed with PCLp associated with bilaterally symmetrical lateral ventricular CPLps without corpus callosal anomalies. Sagittal unenhanced T1 weighted MRI scans of a normal brain with superimposed black shading (black arrows) show morphological classification of PCLps. Anterior.


58-year-old gentleman complaining of recurrent headaches since twelve months diagnosed with PCLp associated with bilaterally symmetrical lateral ventricular CPLps without corpus callosal anomalies. . Posterior).


58-year-old gentleman complaining of recurrent headaches since twelve months diagnosed with PCLp associated with bilaterally symmetrical lateral ventricular CPLps without corpus callosal anomalies. . Appearance as in our case.


A; A dome-shaped, easy-to-bleed nodule on the parietal scalp.


B; Dermal infiltration of atypical keratinocytes with dyskeratotic cytoplasm.


C; Another red nodule that developed in the left temporal region.


D; Dermal infiltration of atypical keratinocytes with dyskeratotic cytoplasm.


E; Keratotic lesions were apparent around the grafted area.


F; Dermal infiltration of atypical keratinocytes with dyskeratotic cytoplasm.


Paraffin-embedded tissue samples from the tumor sites. Were deparaffinized and stained with anti-IL-17R antibody Original magnification, x50.


Paraffin-embedded tissue samples from the tumor sites. Were deparaffinized and stained with anti-IL-17R antibody , x200.


Or surgical margin. Were deparaffinized and stained with anti-IL-17R antibody Original magnification, x50.


Paraffin-embedded tissue samples from the tumor sites. And anti-IL-17 antibody The sections were developed with Liquid Permanent Red. , x100.


Magnetic resonance diffusion-weighted image revealing a bright signal within the tumor.


Postoperative computed tomography scans sagittal.


Axial. Demonstrate gross-total removal of the brainstem tumor.


(a). T2 Weighted magnetic resonance image (MRI) showing right hemispheric atrophy with temporo - occipital cortical hypointensity, prominent sulcal spaces.


(b). Gadolinium enhanced T1 weighted image showing right temporo - occipital sulcal enhancement consistent with pial angiomatosis.


(c). Susceptibility weighted image (SWI) showing intense blooming of temporo-occipital cortex.


A-c Tumoral calcinosis. A; Lesion consisting of an area of basophilic calcified material with surrounding reactive giant cells. Hematoxylin and eosin. X100.


B, c Giant cells in high-power magnification. Hematoxylin and eosin. X200.


Magnetic resonance imaging of the tumor. Thick arrow - The tumor and the thin arrow - Aorta.


Magnetic resonance angiogram: extensive collaterals formed.


The central area of defect was identified as caecal plate "C" with a dilated prolapsed terminal ileum "I" with the length of 4-5 cm presenting as characteristic "elephant trunk deformity. " A small sized opening on the prolapsed terminal ileum which noted to be passing meconium (arrow). On lateral aspects, there were exstrophy bladder plates with two hemispheric bladders "H" each of which contains a visible ureteric orifice "*". Genital anomalies with asymmetrical widely bifid sacro labial folds that were hyperpigmented. The gonad was palpable in the left side with absent phallus.


Computed tomography image showing widening of symphysis pubis indicating an open book pelvic deformity with bilateral congenital hip dislocation, mildly balanced congenital scoliosis, multilevel vertebral failure of formation and segmentation with hemivertebra seen at the midthoracic and lumbosacral regions, and posterior spinal dysraphism at the lower lumbosacral region, associated with low-lying spinal cord that herniates dorsally representing myelomeningocele.


27-year-old female with poor vision and inability to hear was subsequently diagnosed with CHARGE syndrome. (a and b) Standard photographs of the ears from lateral view show bilateral microtia grade I/II (arrows).


27-year-old female with poor vision and inability to hear was subsequently diagnosed with CHARGE syndrome. (a and b) Fundus photographs (antero-posterior view) show bilateral, symmetrical, chorioretinal colobomata involving the optic discs and macula (arrows).


Renal biopsy - light microscopy. . Notes: Light microscopic examination of renal biopsy: (A) trichrome stain showing moderate tubular atrophy, interstitial fibrosis and interstitial inflammation (affecting 50% of cortical area). No interstitial granulomas are seen.


Renal biopsy - light microscopy. (B) Hematoxylin and eosin stain of glomeruli showing glomerular crescent.


Renal biopsy - light microscopy. (C) Trichrome stain of glomeruli showing necrotizing crescent. Out of 19 glomeruli examined, nine showed complete or near complete global sclerosis.


Renal biopsy - immunofluorescence microscopy. . Notes: Immunofluorescence microscopy of renal biopsy (A and B): Immunofluorescence (IF) staining shows weak linear staining of glomerular basement membranes for IgG. Area of non-staining in figure B represents crescent. The IF was also positive for kappa and lambda light chains (not shown). Segmental glomerular tuft staining for IgM, C3, and fibrinogen were also positive (not shown). The linear staining for IgG was not seen in the previous kidney biopsy and suggests the possibility of coexistent pauci-immune glomerulonephritis and anti-glomerular basement membrane nephritis.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (A) Hematoxylin and eosin (H&E) stain of glomeruli showing cellular crescent.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (B) H&E stain of another glomeruli showing cellular crescent.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (C) Trichrome staining of glomeruli showing necrosis (red).


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (D) Trichrome staining of another glomeruli, showing necrosis (red).


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (E) Trichrome staining showing moderate tubular atrophy and interstitial fibrosis. Immunofluorescence staining was negative (not shown). Electron microscopy revealed 30% foot process effacement but no immune type electron dense deposits or endothelial tubuloreticular inclusions (not shown).


Clinical features of dermatomyositis with shawl-like rash affecting neck, chest and back. A; Flagellate erythema upper back.


Clinical features of dermatomyositis with shawl-like rash affecting neck, chest and back. B; 'V' neck distribution of erythema.


The lung infiltration resolved in the chest X-ray following the treatment.


Axial CT with mass measuring ~11 cm x 10 cm.


Sagittal CT with mass measuring ~9 cm x 7.5 cm.


Coronal CT with mass measuring ~12.5 cm x 8.5 cm.


Endoscopic evidence of narrowing due to external compression in sigmoid colon.


Mucosal ischemia at level of stenosis from external compression.


Gross pathology demonstrating mass with intimate association to sigmoid colon with involved mesentery and ileum resection. Posterior view.


Gross pathology demonstrating mass with intimate association to sigmoid colon with involved mesentery and ileum resection. Anterior view.


Squamous portion of the tumor. Demonstrates keratinization and intracellular bridges. There is a variation in size of the nuclei, there is nuclear atypia and prominent nucleoli.


Chondroid portion of the tumor as well as cartilaginous matrix and various shapes/sizes of chondrocytes.


Spindle cell sarcoma component of the tumor.


Adenocarcinoma features with gland formation by cuboidal to columnar cells. Nuclei with intracytoplasmic mucin droplets and some very large, atypical nuclei are seen.


Clinical photo - second outbreak of herpes zoster in erosive pustular dermatosis of the scalp.


Clinical photo - after resolution of second outbreak.


Trichoscopy image - herpes zoster infection - Perifollicular serous exudate, Patchy brown-gray skin hyperpigmentation.


Trichoscopy image - after resolution of herpes outbreak with atrophic scar.


The lesion.


Other view of the lesion.


Histopathology.


Infiltrated plaques on nose, left dorsum of wrist and on index finger of right hand.


Nodular lesions on dorsum of both hands.


CT scan showing multiple osteolytic lesions of lumbar vertebrae and pelvis.


FDG-PET scan revealing diffuse medullar FDG-uptake.


Preoperative sagittal and coronal T1 MRI of the brain (a and b) shows a large T1 hyperintense multilobulated lesion extending along the floor of the left anterior and middle cranial fossa, with areas of T1 hypointense signal around the component in the left anterior cranial fossa. Locules of T1 hyperintense material are present throughout the subarachnoid spaces along the sylvian fissures bilaterally, extending into the frontal sulci, parasagittal frontal lobes, tectum, and into the posterior fossa. Fat-fluid levels are present within the ventricular system, with evidence of obstructive hydrocephalus.


Postoperative sagittal and coronal MRI of the brain (a and b) with evidence of gross total resection of the dermoid cyst along the anterior cranial fossa floor, with residual intraventricular and subarachnoid fat droplets.


Histopathologic examination. Hematoxylin and eosin (H and E) stained sections x40, x100, and x40, respectively, showing the typical histologic components of the dermoid cyst.


(a) Hematoxylin and eosin-stained section showed a cellular tumor with round nuclei, coarse chromatin, small to conspicuous nucleoli and moderate amount of eosinophilic cytoplasm.


Arrow points to a cell with tailing of the cytoplasm.


Myogenin immunohistochemistry showed diffuse strong nuclear staining. Diffuse strong cytoplasmic staining for desmin and vimentin, respectively.


Pelvic computerized tomography revealed a 3.5 cm tumor at the left lateral wall of the bladder (arrow).


Tumor have an epitheloid and sarcomatoid areas (H&E x 200).


Case 1 preoperative contrast-enhanced T1-weighted MRI scan:. Sagittal.


Coronal. Arrows delineate the thin rim of normal pituitary gland draped superiorly over the tumor.


Case 1 2-month postoperative contrast-enhanced T1-weighted MRI scan:. Sagittal.


Coronal. Arrows delineate the proximal and distal aspect of the pituitary stalk.


Multiple flesh coloured plaques on the : lower trunk thighs.


Vulva.


Histopathology (H&E) shows discohesive nests and sheets of malignant small round blue cells having hyperchromatic to vesicular nuclei, prominent nucleoli and scant to moderate pale eosinophilic cytoplasm.


View of the asymmetrical hypertrophy of the right tonsil with a mass arising in its upper pole.


View of the hypertrophic right palatine tonsil in T2-weighted MRI.


Cystogram (07/01/2020). A; CT cystogram shows no contrast extravasation from the bladder. The closed suction drain remains in place. Lymphocoeles are present in the inguinal sites.


Rendezvous procedure (07/02/2020). A guidewire was passed through the right nephrostomy down the ureter to the ureteral leak and left in place. Cystoscopy and then ureteroscopy were performed. The guidewire in the right ureter was grasped through the ureteroscopy and pulled into the bladder.


Placement of a ureteral stent from the right kidney into the bladder (07/02/2020). Using the guidewire, a nephroureteral stent was passed into the right kidney, down the right ureter and past the ureteral leak into the bladder (indicated by an arrow). The closed-suction drain in the operative site remained in place.


Frontal view at the time of presentation.


Profile view at the time of presentation.


Axial view MRI showing multiple cysts with hyperintense T2 weighed images.


Coronal view MRI showing multiple cysts with hyperintense T2 weighed images.


Frontal view after two years of follow up.


Profile view after two years of follow up.


Axial.


Coronal. Postcontrast computed tomography images demonstrating a fairly well-defined solid tumor with heterogeneous enhancement in the right kidney (arrows). Neither signs of invasion of the hilum vessels nor hydronephrosis was observed.


Axial (a and b) postcontrast computed tomography images of the pelvis showing an enlarged uterus with multiple large leiomyomas (arrows), predominantly in subserosal and intramural locations.


Clinical and MR image of intravaginal mucosal metastasis of a malignant melanoma of the urethra. /. (A) Target lesion before injection of T-VEC. Baseline image shows a pigmented ulcerated mucosal tumor (arrow).


Clinical and MR image of intravaginal mucosal metastasis of a malignant melanoma of the urethra. Visual appraisal with speculum. (B) Target lesion after seven injections of T-VEC: partial response with substantial regression of the injected mucosal metastasis (arrow) and cessation of intravaginal bleeding.


Clinical and MR image of intravaginal mucosal metastasis of a malignant melanoma of the urethra. C/D MR image. (C) Transverse T2-weighted fat suppressed MR image shows labial metastasis (arrow) before injection of T-VEC.


Clinical and MR image of intravaginal mucosal metastasis of a malignant melanoma of the urethra. (D) Transverse T2-weighted fat suppressed MR image 2 months upon T-VEC therapy shows complete disappearance of labial metastasis (arrow indicating the original location).


Summary of the sequential treatment in our case of advanced mucosal melanoma.


Crusted lesions involving seborrheic areas of the chest.


Results of immunoblot analysis on patient serum collected on week 7 (timepoint corresponding to the tumor diagnosis). The probe of the patient showed positivity for the 130-kDa band, corresponding to anti-DSG3 antibodies. No bands corresponding to anti-desmoplakin (anti-DSP I-II), anti-envoplakin (anti-EVPL), anti-periplakin (anti-PPL), or other autoantibodies specific for paraneoplastic pemphigus were detected in the analyzed serum. Double lanes for each serum: the first one corresponds to epidermal extracts prepared with 6 M urea, and the second one was for that prepared with 1% SDS.


Graph showing the trend of Pemphigus Disease Activity Index score and anti-desmoglein serum titer. Week 0 is considered the time of onset of gastrointestinal symptoms. Week 4: clinical worsening and increase in anti-desmoglein titers. Week 7: diagnosis of esophageal mass. Week 9: end of the first IvIG cycle. Week 13: end of the second IvIG cycle. Week 16: first rituximab infusion. Week 19: end of rituximab therapy. Week 21: start of prednisone, 0.6 mg/kg/day. Week 23: clinical follow-up and re-assessment of anti-desmoglein titers. The titers seemed to predict the clinical worsening of the disease, which remained stable during the period of IvIG infusions. The worsening following the surgical intervention showed a prompt response to rituximab. The timing of single treatments is indicated above.


Microscopic findings of the resected appendix showed a diffuse eosinophilic infiltration from the muscular layer to the subserosal layer of the appendix wall (H&E stain,. X40.


Microscopic examination of the gastric antrum. H&E stain, x400).


Duodenum. H&E stain, x400) showed inflammation with eosinophilic infiltration. Extracellular eosinophilic staining constituents were observed in the lamina propria.


A punch biopsy of the abdominal skin revealed perivascular and interstitial inflammation with marked eosinophilic infiltration from the dermis to the subcutaneous fatty layer (H&E stain, x400).


OPG.


CT scan showing bilateral falx cerebri calcification.


Chest x-ray exhibiting splayed ribs.


Gross specimen showing multiple soft tissue thin cystic lining.


Parakeratinized palisaded corrugated epithelium.


Islands invading in connective epithelium.


Pedigree chart.


Showing multiple, deep, pock-like scars with comedones over nose.


Cheek.


Multiple comedones with pigmented papular lesions over flexor aspect of arm. Multiple comedones and pigmented papules on the upper back.


Multiple comedones with pigmented papular lesions more clustered over Elbows.


Facial sparing. Multiple comedonal papules over lower limbs.


Serum creatinine trend over time.


A: Hematoxylin and eosin (H & E) stain of initial (6/2011) renal biopsy, x 20 magnification, demonstrating interstitial inflammatory infiltrate with normal glomerulus.


B: H & E stain of initial renal biopsy (6/2011), x 40 magnification, depicting normal glomerulus and no glomerular hypercellularity, fibrinoid necrosis or crescent.


C: H & E stain of third renal biopsy (2/2018), showing persistent interstitial inflammatory cell infiltrate and glomerulosclerosis.


D: Trichrome stain of third (2/2018) renal biopsy, highlighting diffuse, extensive interstitial fibrosis and global glomerulosclerosis (blue).


Pathogenic germline MEN1 variant (c.654 + 1G > T, IVS3, g.3405G > T) identified in the present MEN1 case reported with hydrocephalus and intracranial hypertension for giant prolactinoma. The change in heterozygous of the nucleotide guanine for timine at the canonic region +1 of the intron 3 of the MEN1 gene (c.654 + 1G > T; HGMD: CS982266; dbSNP: rs794728622) results in a splicing donor variant (ref. seq: ENST00000312049; NM_130799).


T1-weighted sagittal view showing a hypointense lesion in the posterior fossa, with displacement of the brainstem and the cerebellum.


T1-weighted axial view showing mildly enlarged ventricles and a contrast-enhancing lesion in the posterior fossa, exerting mass effect on the brainstem.


Patient photographs. A; Conjunctival chemosis is shown adjacent to the lacrimal caruncle at the first examination.


Patient photographs. B; The lacrimal caruncle is partially observed preoperatively during eyelid closure.


Patient photographs. C; No conjunctival chemosis is observed 1 month postoperatively.


Patient photographs. D; Postoperatively, the lacrimal caruncle is hidden during eyelid closure.


Computed tomography brain axial showing.


Diffuse soft-tissue mass in scalp. Associated calvarial defect (marked with orange arrow head).


(c and d) Magnetic resonance imaging showing diffusely enhancing soft-tissue scalp mass.


99m technetium-pertechnetate Meckel's diverticulum scintigraphy: Sequential images showing appearance of abnormal focus (arrow) having temporal correlation with gastric activity and wandering in various quadrants maintaining its compactness.


Sagittal MR image of the thoracic spine. Left: T1-weighted image. The tumor represents as a hypointense mass infiltrating the spine with spinal canal penetration. Right: T1-weighted, contrast enhanced image. Inhomogeneous gadolinium distribution.


T1-weighted, contrast enhanced transverse MR image of the thoracic spine. Inhomogeneous gadolinium distribution. Solid mass in the posterior inferior mediastinum with spinal canal infiltration and myelon compression.


Anterior approach: Thoracolumbophrenotomy with en-bloc resection.


Mononuclear tumor cells with a mix of giant cells, spindle cells and round shaped cells. Hyperchromatic nuclei, partly pale and deeply eosinophilic cytoplasm.


Previous treatment with corticosteroids. . Abbreviations: BM, betamethasone; FM, fluorometholone; PSL, prednisolone; HSK1, herpes simplex keratitis (geographic ulcer and stromal keratitis); TLO, trabeculotomy; TLE, trabeculectomy; HSK2, herpes simplex keratitis (stromal keratitis); PKP, penetrating keratoplasty; CI, corneal infiltration of unknown cause; FK, fungal keratitis.


Simple head CT scan obtained from axial plane.


Sagittal plane.


Coronal plane Heterogeneous tumor lesion of the sellar region is observed, with maximum dimensions of 59 x 52 x 68 mm (white arrow), causing widening of the sella turcica (blue arrow), with a hyperdense area compatible with tumor hemorrhage, causing collapse of the third ventricle and dilation of the occipital horn of the right lateral ventricle (arrowheads).


Simple chest CT scan obtained from coronal plane.


Axial plane There is evidence of an increase in the bilateral pulmonary vasculature (black arrows), multilobar infiltrate with a reticulonodular pattern (white arrows) and ground-glass opacities (arrowheads).


Abdominal computed tomography revealing a right renal enhancing mass about 5 cm in length, accompanied by the parenchyma invasion and pelvis expansion of the right kidney. . Notes:. Cross section.


Abdominal computed tomography revealing a right renal enhancing mass about 5 cm in length, accompanied by the parenchyma invasion and pelvis expansion of the right kidney. Coronal plane.


(A and B) Removing the entire right kidney under robot-assisted laparoscopic nephrectomy.


Pathological features of the surgical specimen. . Notes: (A and B) Microscopic view of the tumor of the right kidney with H&E staining, revealing that tumors were composed of a monotonous population of small round cells. Magnification details:. 40x.


Pathological features of the surgical specimen. . Notes: (A and B) Microscopic view of the tumor of the right kidney with H&E staining, revealing that tumors were composed of a monotonous population of small round cells. 200x.


Pathological features of the surgical specimen. Immunohistochemical staining was positive for. CD99,. 100x.


Pathological features of the surgical specimen. SYN,. 100x.


Pathological features of the surgical specimen. FLI1, and . 200x.


Pathological features of the surgical specimen. Ki67. 100x.


Fluorescence in situ hybridization testing demonstrated that more than 10% of cells were positive indicating EWSR1 gene rearrangement.


A histopathology section. x 200. A closer view of the pathognomonic features of porokeratosis.


A histopathology section. x400. A section showing abnormal vacuolated keratinocyte clones that develop in between normal cells and interrupt the granular layer, with no granules in the abnormal cells. A column of parakeratotic cells forms, called the cornoid lamella.


A histopathology section. x400. Another lesion with similar features to figure 5.


(a) Preoperative coronal T1-weighted MRI showing smooth contours and oval shape of the lesion and medial displacement of the intracavernous portion of the internal carotid artery without enhancement or narrowing.


(b) Preoperative axial T2-weighted MRI showing a hyperintense lesion close to the left internal carotid artery with heterogeneous signal characteristics.


(c) Preoperative axial T1-weighted MRI showing the same lesion with heterogeneous gadolinium enhancement.


Immediate post-op CT scan showing complete tumor removal.


No ocular nerve palsies were seen post-op.


2-month post-op MRI with no residual lesion.


Swelling over scrotum and penis. Warty crusted lesions over lower abdomen, groin and thighs.


Protean lesions over forehead and neck. Discharging sinus over right axilla.


Gadolinium-enhanced magnetic resonance (MR) images. A : Preoperative MR image revealing the mass extended toward the middle fossa laterally and to the sphenoid sinus anteriorly. This lesion also extended to the cerebellopontine angle posteriorly with a compression of the brain stem.


Gadolinium-enhanced magnetic resonance (MR) images. B : Postoperative MR image revealing resolution of the mass over the cavernous sinus region sinus.


Photomicrographs of the lesion showing a non-caseating granuloma (circle,. H&E, original magnification, x100.


With an asteroid body (arrow,. , x400.


Thigh MRI. T1-weighted-axial plane.


T1w with gadolinium-saggital.


T1w with gadolinium-axial.


(c) T2w coronal.


(d) Diffusion sequence.


Medical image.


Vimentin 20X. KI67 40X. Cerebellar tumor: Dedifferentiated tumor metastasis, sarcomatous in appearance with a fusiform pattern, marked nuclear atypia, high mitotic rate, compatible with previous tumor metastasis. In the immunohistochemical study, it only expresses vimentin, with the absence of expression of the S100 protein and also the gliofibrillar protein and liposarcoma markers.


CT scan of the abdomen and pelvis, axial.


Sagittal. Views. The mass can be seen extending anteriorly and superiorly from the dome of the bladder (arrows).


Ultrasonography of the upper pelvis, transverse.


Sagittal. Views. The heterogeneous mass (arrows) lies superficial to the bladder, which is decompressed with a Foley catheter.


CT scan.


Ultrasound. Of the pelvis. These studies demonstrate a smaller, heterogeneous mass (arrows) with a solid superior compartment and a walled-off, phlegmon-filled inferior compartment.


Pityriasis rosea-like eruption presenting as multiple discrete erythematous oval patches and plaques on the back.


Lower abdomen, and bilateral upper thighs.


Lesions distributed along cleavage lines without prominent scales.


Central dusky-red erythematous on some plaques.


Almost all lesions fading with associated post-inflammatory hyperpigmentation after treatment.


(A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20).


Histopathologic features:. Microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and ,interface dermatitis (hematoxylin-eosin, scale bar represents 100 mum).


Microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 mum).


Ulcerated lesions on the scrotum.


Lower abdomen. Of the patient.


O. ovis larvae (x400) showing segments with intersegmental spine bands (1), tufts of brown hooks on the margins of each body segment (2), oral hooks (3), and oral hooks seen attached to the internal cephalopharyngeal skeleton (4).


(a) Cytology smear showing dispersed population of lymphoid cells admixed with fibrous stroma (Pap, x40).


(b) Cytology smear showing atypical lymphoid cell with cerebriform nucleus and prominent nucleoli (Pap, x1000). Inset shows CD4 positivity in tumor cells (IHC, x400).


Pinpoint opening over scar tissue.


Salivary flow intra-orally.


Gutta-percha in fistula.


Fistulography.


Relation of fistulous tract with Stenson's duc.


Suturing.


Follow-up after 1 year.


Physical findings in the patient. Multiple melanotic macules on the fingertips characteristic or Peutz-Jeghers syndrome.


Physical findings in the patient. Melanotic macule on the right cheek.


Skin lesions due to Ornithonyssus bursa (arrows).


Ventral view of Ornithonyssus bursa adult female showing the posteriorly narrowed genitoventral shield (upper arrow) and the teardrop-shaped anal plate with anal opening at the anterior end (lower arrow). Scale bar: 50 mum.


Detail of the sternal shield bearing three pairs of setae. Scale bar: 50 mum.


Alinear area of scarring alopecia on the vertex of the scalp.


An area of whorled scarring alopecia from the occiput to the vertex.


(a) Multiple skin-colored papulonodular lesions affecting forehead, upper lip, nasolabial folds (arrow).


(b) Single, smooth surfaced, skin colored dome shaped nodule over scalp (arrow).


(c) Similar lesions in elder sister (arrow).


(d) Similar lesions in her son (arrow).


Case 1 - Scarring alopecia of the scalp associated with diffuse hypopigmentation, sparse follicular plugs, and diffuse scaling at the borders of the alopecic areas.


Case 1 - Dermoscopy guided biopsy, the area shows numerous yellow keratotic plugs.


Case 3 - Alopecic patch showing erythema and pigmentation.


Case 3 - Dermoscopic images showing follicular keratin plugs.


CECT image of mucocele appendix, with wide base and communicating with caecum.


Intraoperative pictures of mucocele appendix.


Macroscopic view of mucocele appendix with mucous as content.


Yoked Prism Spectacles, Prescribed to Compensate for Head Turn.


Linkage Analysis by Phenotype.


The fractured ABS phaco tip within the silicone sleeve inside the anterior chamber (red arrow).


Electron microscopy of the distal end of the titanium tip.


Which reveals a smooth break near the microhole of the ABS tip.


Magnified view (electron microscopy) of the distal fragment. Magnified view (electron microscopy) of the proximal fragment with a smooth break near the microhole of the ABS tip.


Arrow showing sprengel deformity.


Arrows showing odontogenic keratocyst.


AP chest and neck radiograph showing spina bifida of C5 and C6 vertebrae and partially fused left and right 4th and 5th ribs.


Panoramic examination of patient 1. The examination shows radiopaque lesions just inferior to the right mandibular condyle and the mandible angle.


Computed tomography with solid prototype. Solid prototype in up.


Computed tomography with solid prototype. Lateral. View showing osteomas in the condylar region and mandible angle that were surgical removed.


Panoramic radiographic patient 2. The presence of osteoma in the left condylar region (arrow head). Note supernumerary teeth in the mandible and maxilla (long arrow). Osseous dysplasia can also be observed throughout the mandibular body (short arrow).


Clinical features: The lesion located in the posteromedial region of the left leg.


Pre-operative X-rays showed a nodular mass at the proximal third of the left leg.


Magnetic resonance imaging (MRI).


Vascular MRI. Showed a posterolateral dislocation of the distal part of popliteal artery and tibioperoneal trunk, without alterations in canalization.


Surgical and histological images: En bloc excision of the tumor. Gross examination of a well-circumscribed, nodular, white-gray.


Stiff mass.


Microscopic findings x120.


X200. Showing that the lesion consisted in a multinodular growth with lobules of hyaline cartilage with a low cellularity and bland-looking chondrocytes (hematoxylin/eosin stain).


Larva extraction and size.


Imunohistochemistry and Chromogenic In Situ Hybridization (CISH) analysis of the three lesions. COX2 immunohistochemistry (x200) positive for the meningioma lesion and negative for the primary and recurrent gliosarcoma. MGMT staining (x200) was only positive for the meningioma. EGFR immunostaining was negative in primary gliosarcoma and meningioma, with recurrent gliosarcoma exhibiting strong positivity. CISH analysis of EGFR confirmed these findings after EGFR amplification.


(b) Polyacrylamide gel electrophoresis of Reverse transcription polymerase chain reaction (RT-PCR) products. The present case showing a 166 bp band of type2 EWSR1/FLI1 fusion (lane 1).


Indices of the bullous pemphigoid (BP) disease area index scores and enzyme-linked immunosorbent assay (ELISA) using full-length recombinant BP180 during the clinical course.


Non-axial proptosis, marked eyelid edema of upper and lower eyelid with purulent discharge.


Axial view of CT scan showing orbital sub-tissue swelling and sub-periosteal abscess on the upper lateral orbital wall (black arrow).


Ziehl-Neelson staining was found acid fast bacillus (black arrow).


Day 15, Stable systemic condition with eyelid swollen and abscess resolved.


Contrast-enhanced CT scan axial soft-tissue window.


Axial.


Coronal bone window. Sections revealing polypoidal soft tissue occluding the external auditory meatus (arrow) with increased bulk and heterogeneous enhancement (arrowhead) of the nasopharynx, base of skull, and masticator muscles signifying inflammatory soft tissue. Bone window sections showing erosive changes in the bones of the skull base (curved arrows) signifying osteomyelitis.


Facial erythema, oedema and numerous pustules with crusting around the nose and mouth.


Chest: pustules on an erythematous base.


Multiple indurated plaques over the face, in particular, over the nasal bridge, the brow, the outer maxillary area, and both ears.


H&E-stained section of a skin biopsy showing a dermal inflammatory infiltrate separated from the epidermis by a Grenz zone (a).


The inflammatory infiltrate shows abundant foamy macrophages.


Which contain acid-fast bacilli (arrows), identified on Fite stain.


Subcutaneous tissue showing areas of neutrophilic infiltrate, suggestive of erythema nodosum leprosum (d).


Lesion at the medial canthus, with free-moving maggots.


Mechanical removal of maggots with wound debridement.


Follow up at 2 weeks, with completely healed wound.


Maggots removed from patient's wound.


Incomplete posterior spiracular peritreme of Chrysomya bezziana.


Coronal STIR A. , axial T1W B.axial contrast enhanced T1W C. MR images obtained 2 years after the surgery: postoperative changes in the operation area (arrows), no sign detected related to the recurrence.


Coronal. T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesion with parenchymal invasion along the right frontal lobe (arrow).


Axial ,. Along the falx cerebri.


Coronal. Right temporal lobe.


Sagittal. T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesions through the frontal sinus, and . Right sphenoid wing. (arrows).


Axial.


Sagittal. T1-weighted magnetic resonance imaging showing a contrast-enhancing sinonasal mass with intracranial extension through the cribriform plate into the anterior cranial fossa, maxillary, and sphenoid sinuses.


Sagittal T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesions posterior to C2 vertebral body.


Posterior to T9-T10 disc space.


Along the posterolateral dura at the L3-L4 level. (arrows).


A 4-month-old female with emesis. Coronal T2 3D magnetic resonance cholangiopancreatography shows the pancreas divisum with the main pancreatic duct draining into the duct of Santorini (arrow). The common bile duct drains into a complex conglomeration of pancreatic head cysts (asterisk). The common bile duct is mildly prominent, and there is ascites.


Same patient as above. Coronal T2 3D magnetic resonance cholangiopancreatography shows the 1.9 cm common cyst (arrow) that drains the duct of Santorini and the common bile duct. There are multiple cysts and ducts that extend throughout the pancreatic head with multiple connections to the duodenum (asterisk).


Same patient as above. Axial T2 fat-saturated image shows a large pancreatic pseudocyst (asterisk), with layering debris, exerting mass effect on the pancreatic head. There is ascites.


Computed tomography urography. CECT showing thickened bladder wall (Red arrow).


(a and b) Urinary bladder biopsy photomicrograph.


Microscopic appearance of the larvae.


Patient with left-sided proptosis.


The follow-up photograph after 1.5 months showing significant resolution of the proptosis.


Contrast-enhanced T1-weighted magnetic resonance imaging in coronal view showing a nonfunctioning pituitary adenoma. The tumor size was 2.5 x 2 x 2 cm, with suprasellar extension and compression of the optic chiasm.


Digital subtraction angiography of the right common carotid artery in lateral view:. Image in arterial phase showing a lesion in the sphenopalatine artery (arrow).


A later image showing arteriovenous shunt with venous filling (arrow) and extravasation of contrast agent (black arrow).


Digital subtraction angiography of the right common carotid artery in anterior posterior view: The arteriovenous fistula is occluded and the posterior septal branch of the sphenopalatine artery (arrow) is occluded.


Extraoral photograph showing the lesion.


Intraoral aspect showing extensive mass involving the maxillary alveolar mucosa.


Computed tomography scan showing extensive infiltrative lesion with displacement of adjacent structures.


Radiographic image showing well-defined radiolucency in relation to 37.


Histopathologic image showing cystic epithelium lined by orthokeratin (H & E, x4).


Histopathologic image showing prominent granular cell layer and lack of palisading of basal cells (H&E, x40).


Histopathologic image showing hematoxophilic foci of calcification in the connective tissue wall (H & E, x100).


Typical ochronotic pigmentation secondary to deposition on the nose, sclera and jowl.


The AP.


Lateral. View of the cervial spine showing reduced disc spaces, pronounced disc calcifications and spondylosis.


Sagittal.


Axial CT. View of the lumbar spine showing the typical vacuum phenomenon and profound water-like calcification with sparing of the central nucleus pulposus.


A and B : The cervical MRI show the spinal cord is compressed at multi-level mainly from the redundant ligamentum flavum posteriorly (C2 : arrow head).


Black oxidized HGA pigmentation (long arrow) is found in the ligamentum flavum between the C2 (arrowhead)-3 lamina.


A and B : The X-ray picture of the laminoplasty procedure postoperatively, which shows the artificial wedged coral bone interposition from the C4 to the C6.


Family pedigree.


Woolly hair.


Right middle lobe syndrome.


CT scan with oral and rectal contrast (R) showing a pelvic mass with multiple heterogeneously enhancing soft tissue masses with central necrotic areas within pelvis not separately seen from the ovaries (EST).


Sagittal section showing heterogeneously enhancing soft tissue lesions within omentum (OM), M- pelvic mass seen indenting bladder base ,. Bowel. Loops are displaced upwards.


Intraoperative omental nodular metastatic deposits (OD).


Metastatic deposits (D) on the descending colon (DC).


H&E x 20: biphasic neoplasm showing both benign epithelial component and sarcomatous mesenchymal component.


Immunostain CK7x20:epithelium is positive for CK7 (brown).


Immunostain, CD10x- Mesenchymal component is positivity for CD-10 (brown).


Anterior-segment findings at the initial ophthalmic evaluation. A slit-lamp examination shows marked chemosis in the right.


Anterior-segment findings at the initial ophthalmic evaluation. Left. Eyes.


Anterior-segment findings at the initial ophthalmic evaluation. AS-OCT clearly shows conjunctival elevation and ciliochoroidal detachments (blue arrows) in all scan directions in the right . The panels shown are scans at nasal.


Anterior-segment findings at the initial ophthalmic evaluation. Left. Eyes. In some scans, dilated lymphatic channels (arrowheads) and fluid space (asterisks) are seen clearly in the thickened conjunctiva. The red arrows in insets indicate the direction of the AS-OCT scans. Temporal.


Anterior-segment findings at the initial ophthalmic evaluation. AS-OCT clearly shows conjunctival elevation and ciliochoroidal detachments (blue arrows) in all scan directions in the right . Temporal.


Anterior-segment findings at the initial ophthalmic evaluation. Left. Eyes. In some scans, dilated lymphatic channels (arrowheads) and fluid space (asterisks) are seen clearly in the thickened conjunctiva. The red arrows in insets indicate the direction of the AS-OCT scans. The panels shown are scans at nasal.


Anterior-segment findings at the initial ophthalmic evaluation. AS-OCT clearly shows conjunctival elevation and ciliochoroidal detachments (blue arrows) in all scan directions in the right . Superior.


Anterior-segment findings at the initial ophthalmic evaluation. Left. Eyes. In some scans, dilated lymphatic channels (arrowheads) and fluid space (asterisks) are seen clearly in the thickened conjunctiva. The red arrows in insets indicate the direction of the AS-OCT scans. Superior.


Anterior-segment findings at the initial ophthalmic evaluation. AS-OCT clearly shows conjunctival elevation and ciliochoroidal detachments (blue arrows) in all scan directions in the right . Inferior. Part of the bulbar conjunctiva. AS-OCT, anterior-segment optical coherence tomography.


Anterior-segment findings at the initial ophthalmic evaluation. Left. Eyes. In some scans, dilated lymphatic channels (arrowheads) and fluid space (asterisks) are seen clearly in the thickened conjunctiva. The red arrows in insets indicate the direction of the AS-OCT scans. Inferior. Part of the bulbar conjunctiva. AS-OCT, anterior-segment optical coherence tomography.


Fundus findings at the initial ophthalmic evaluation. The color fundus photographs show no signs of retinopathy such as retinal hemorrhages and cotton-wool spots in the right.


Fundus findings at the initial ophthalmic evaluation. Left. Eyes.


Fundus findings at the initial ophthalmic evaluation. Macular optical coherence tomography scans show retinal edema temporal to the optic nerve head (white arrows) and serous retinal detachments at the fovea (red arrows) in the right.


Fundus findings at the initial ophthalmic evaluation. Fluorescein angiography shows areas of hyperfluorescence corresponding to the retinal edema at the temporal edge of the optic nerve head (white arrows) in the right.


Fundus findings at the initial ophthalmic evaluation. Indocyanine green angiography shows areas of hyperfluorescence corresponding to the serous retinal detachments in the foveal region (red arrows) in the right.


Clinical manifestation of ACC, absence of the skin on scalp.


Back, buttocks, and upper limbs.


With an atrophic scar on the chest and abdomen.


Complete epithelialization on day 72, on scalp.


Trunk.


Skin-colored-to-hypopigmented, flat-topped papules in linear configuration along the dorsum of the left thumb along with nail plate thinning, longitudinal ridging, and dystrophy seen. Mild subungual hyperkeratosis and hyperpigmentation of the proximal nail fold.


(a-c) T1, T2, T1+C axial cut showing a large lobulated mass in the third ventricle with contrast enhancement.


(d) Flair T2 axial cut with no transependymal edema.


(e and f) T1+C sagittal and coronal views.


(a-c) T2, FLAIR T2, and T1+C showing right intraventricular complex solid, cystic mass with contrast enhancement.


(d and e) T1, T1+C sagittal views.


(f) T2 coronal view of solid cystic tumor.


Illustrated diagram of mass location. Original illustration by YaQun Zhou (2020).


Hematoxylin and eosin stain of patient sample showing characteristic storiform array with mitotic figures.


Immunohistochemistry stain of patient sample showing positive reaction for CD34 markers.


Multidetector-row computed tomography scan clearly showing active contrast extravasation in the lower rectum (arrow).


Photograph showing the exposed blood vessel in the lower rectum during colonoscopy.


The coronal non-contrast-enhanced computed tomography (CT) scan showing the presence of gas in pelvicalyceal systems of both kidneys (white arrows). CT scans were taken at admission to the hospital.


The axial non-contrast-enhanced computed tomography scan showing the presence of gas in pelvicalyceal systems of both kidneys (white arrows) and gas foci in the bladder wall. CT scans were taken at admission to the hospital.


The coronal non-contrast-enhanced computed tomography (CT) scan (The kidneys level) revealed complete regression of the imaging findings of the disease. CT scans were taken on the 27th day of hospitalization.


The coronal non-contrast-enhanced computed tomography (CT) scan (The bladder level) revealed complete regression of the imaging findings of the disease. CT scans were taken on the 27th day of hospitalization.


The patient showing left eye proptosis with inferior displacement of the globe.


(a) MRI, coronal view of a heterogeneous intermediate signal (white arrow) of the left superior orbital mass, infiltrating the superior rectus muscle.


(b) The transverse view of the same heterogeneous mass (black arrow) displacing the globe anteriorly (proptosis).


Mature adipocytes (black arrow) intermingled with zones of atypical stromal cells (white arrow) (200x, H & E stain).


A; Hematoxylin and eosin, x10. Skin punch biopsy from right leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis.


B; Hematoxylin and eosin, x40. Skin punch biopsy from the right leg exhibits almost confluent parakeratosis and an absent granular layer with Munro's microabscesses. Some dilated papillary dermal vessels are noted.


C; Hematoxylin and eosin, x20. Skin punch biopsy from left leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis. Absent granular layer is evident, with denuded foci. Also seen is a hair follicle with parakeratotic plugging.


D; Hematoxylin and eosin, x40. Skin punch biopsy from left leg exhibiting almost confluent parakeratosis and an absent granular layer with Munro's microabscesses.


A; Improvement of both legs after 52 weeks of treatment with etanercept.


B; Improvement of both elbows after 52 weeks of treatment with etanercept.


A series of PET/CT scans (Maximum Intensity Projections) in the first patient showing:. Signs of peritoneal carcinomatosis in the subdiaphragmatic space infiltrating the large omentum, and ,associated with ascites, in addition to supradiaphragmatic laterocervical, and ,mediastinal lymphadenopathies.


Persisting multiple peritoneal implant lesions at the time of treatment initiation.


A significant improvement of the previously described peritoneal lesions with an overall regression of their metabolic activity.


Transvaginal pelvic ultrasonography revealing hyperechogenic nodule.


(A, B) Cystourethroscopy showing pedicled mass arising from the right ureteral orifice.


(C) Postresection area showing no signs of remnant tumor.


Follow-up magnetic resonance imaging 2 months after procedure showing no abnormalities.


Immunoreactivity was shown for desmin.


Muscle-specific actin.


Estrogen receptors.


(A) Diagnosis: histological image of hematoxylin and eosin. Section (scale bar: 50 microm) shows small tumor cells with a round-oval nucleus and poor cytoplasm that are very densely arranged in a diffuse pattern of growth.


Post-debulking surgery restaging:. Post-debulking clinical presentation with a purplish lesion (approximately 1.5 x 1.5 cm) situated near the right preauricular region close to the surgical scar.


(C) Face and neck CT scan (axial projection) showing residual disease in the right preauricular region. CT, computed tomography.


Coronal. Cross sections before biopsy (2008).


T1-weighted magnetic resonance imaging, axial.


T1-weighted magnetic resonance imaging (October 2010) before second resection (November 2010). Coronal.


T1-weighted magnetic resonance imaging (October 2010) before second resection (November 2010). Axial.


T1-weighted magnetic resonance imaging (October 2010) before second resection (November 2010). Sagittal. Cross sections: tumor regrowth.


Intraoral photograph showing the nodular and variegated appearance of the tumor.


Tumor bed after complete excision of the tumor mass.


Intraparenchymal macrovesicular steatosis (Grade 3) and granulomatous formations consisting of epitheloid histiocytes and multinuclear cells (H&E, x100).


Intraparenchymal macrovesicular steatosis (Grade 3) and granulomatous formations consisting of epitheloid histiocytes and multinuclear cells (H&E, x200).


Intraparenchymal macrovesicular steatosis (Grade 3) and granulomatous formations consisting of epitheloid histiocytes and multinuclear cells (H&E, x400).


12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. (a and b) T2-weighted axial images show hyperintensities in periventricular (single arrow) and bilateral frontoparietal region with frontal predominant cortical thickening (double arrow) with paucity of sulci favoring cortical dysplasia with pachygyria.


12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. T2-weighted axial images show "tigroid-like stripes"(single arrow) along with frontal predominant cortical thickening (double arrow).


12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. Fluid-attenuated inversion recovery image shows hyperintensities in bilateral subcortical white matter (thin triple arrow) suggesting myelination abnormality.


12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. T2-weighted sagittal images. Show radial stripes (single arrow).


12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. : show scattered dots in form of hyperintensities on a normal background white matter (double arrow) - "leopard-like appearance" along with a normal appearing cerebellum.


12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. Awake electroencephalogram of the child shows background high amplitude polymorphic delta wave activity with multifocal spikes.


(A-D) The enhanced Magnetic Resonance Imaging (MRI) performance of Case 1.


(A-E) The enhanced Computed Tomography (CT) and three-dimensional reconstruction performance of Case 2.


(A-I) The enhanced Computed Tomography (CT) and three-dimensional reconstruction performance and the intraoperative situation of case 3.


Eccrine porocarcinoma, histopathology. The tumor displays solid and trabecular architecture, with a large growth front (HE, X5).


Eccrine porocarcinoma, histopathology. Major cellular pleomorphism, high mytotic activity, microcysts (HE, X40).


Cervical CT-scan (coronal view). Left cervical adenopathy (in green circle).


Metastatic lymphadenopathy. A: lymph node metastasis (HE, x5).


Metastatic lymphadenopathy. B: satellite tumor lymph node (HE, x 2,5).


Heliotrope rash: purple-reddish rash on the upper eyelids accompanied by eyelid swelling.


Ulcer of the right elbow (usually indicates significant vasculopathy in JDM).


Gottron's papules and signs: papulosquamous and macular erythematous lesion over the dorsal surface of Knuckles.


Contracture of joints (rigidity of the joints due to inflammation and hardening of muscles).


Juvenile dermatomyositis: skeletal muscle biopsy with characteristic perivascular mononuclear cell infiltrate (HE, x400).


Sinus computed tomography (CT) scan at the clinical onset. Axial.


Sinus computed tomography (CT) scan at the clinical onset. Sagittal. CT scan examination with soft-tissue algorithm showing right maxillary invasive sinusitis. Note focal sinus medial wall discontinuities (red arrows in a) and partial obliteration of normal fat planes in the pterygomaxillary fissure (arrowheads in a and b).


Sinus magnetic resonance imaging. Axial.


Sinus magnetic resonance imaging. Coronal. Fast spin echo T2-weighted images show low signal effusion in the left maxillary sinus, at the level of ethmoidal air cells and sphenoid sinus, predominantly on the right (arrows).


Painful, deep ulcer in the left buccal mucosa at age 26.


A; A well-demarcated nodule on the retroauricular skin, 20 x 20 mm in size.


B; Magnetic resonance imaging revealed a subcutaneous nodule located adjacent to the periosteum.


C, d Proliferation of fibroblastic and histiocytic cells showing storiform-type whorling and a plexiform pattern. Original magnification: x100.


Paraffin-embedded tissue samples were deparaffinized and stained with anti-POSTN antibody.


Anti-CD163 antibody.


Anti-CD206 antibody The sections were developed with liquid permanent red. Original magnification: x200.


(A) Major ulcers, 15 cm in diameter, with clear lines, elevated cyanotic edges on the front surface of the scrotum. The surface was presented by tender granulations, with parts showing yellow purulent discharge thickenings. On the internal surface of the hips there were ulcers 3x5 cm in size, with clear lines, even edges, and tender granulations on the bottom of the ulcers and yellow-green purulent discharge thickenings. The penis was deformed, and was actually presented by the urethra, covered with granulation tissue (before the treatment).


(B) Occlusive dressing with an epithelizing ointment.


(C) Complete healing through granulation and scarring of ulcers on completion of the 24-week treatment.


Lack of epidermis, infiltrate in the upper and mid dermis, which was mostly made up of leukocytes, lymphocytes, and histiocytes; absence of leukoplakia, widened vessel walls, gaping lumen, and disconnection between infiltrate and vessels (Magnification x100).


Subfoveal optical coherence tomography images of case 2. A; Small amount of subretinal hyperreflective materials, focal outer retinal disruption, and subfoveal retinal pigment epithelium (RPE) hyperplasia were observed at the administration.


Subfoveal optical coherence tomography images of case 2. B; The recession of RPE hyperplasia occurred 9 months after the introduction of adalimumab.


Mass lesion at left root of neck, unspecified origin (arrow).


Fundus photographs, OCT image, and fluorescein and indocyanine green angiograms in a patient with RAP and an RPE tear that developed 2 months after vitrectomy for vitreomacular traction. A; Fundus photograph 2 months after the vitrectomy. Note the large defect of the RPE (arrowheads) and the rolled epithelium (arrow) temporal to the fovea.


Fundus photographs, OCT image, and fluorescein and indocyanine green angiograms in a patient with RAP and an RPE tear that developed 2 months after vitrectomy for vitreomacular traction. B; OCT image shows an accumulation of intra- and subretinal fluid. The RPE is rolled (arrow), and the area not covered by the RPE can be seen (arrowheads).


Fundus photographs, OCT image, and fluorescein and indocyanine green angiograms in a patient with RAP and an RPE tear that developed 2 months after vitrectomy for vitreomacular traction. C; Fluorescein angiogram shows an area of hyperfluorescence corresponding to the RPE tear (arrowheads).


Fundus photographs, OCT image, and fluorescein and indocyanine green angiograms in a patient with RAP and an RPE tear that developed 2 months after vitrectomy for vitreomacular traction. D; Indocyanine angiography shows the neovascular lesion covered by the contracted RPE (arrow).


Multiple papules and nodules along with the superficial venous lines on the flexor.


Extensor aspects of the right forearm.


The newly developed lesions along the peripheral cephalic veins of the right.


Left forearms.


Transcutaneous ultrasonography showing hypoechoic masses that surround the superficial vein, as indicated by yellow arrows (e, f).


A; Histopathology showing nonnecrotic, noncaseation granuloma in the deep dermis and adipose tissue. HE. X10.


B; A high-power view of the dermal granuloma with relatively low inflammatory cell infiltrations. HE. X200.


Positron emission tomography screening exhibited BHL.


A solitary mass in the left gluteus minimus muscle , as indicated by orange arrows.


Hyperostotic esthesioneuroblastoma in 65-year-old male mimicking fibrous dysplasia. . A, B. Axial and coronal CT images show diffuse sclerotic expansile bones of anterior skull base and superior sinonasal cavity (arrows). Hyperostotic bones show homogeneous, ground glass appearance.


Hyperostotic esthesioneuroblastoma in 65-year-old male mimicking fibrous dysplasia. C, D. Axial T2 and post-contrast T1 fat saturated MR images show enhancing rind of soft tissue mass (curved arrows) along hyperostotic bones (dashed arrows) which shows mild heterogeneous enhancement. Note formation of small cysts at tumor-brain interface (short arrows). Note formation of mucocele (long arrow).


Hyperostotic esthesioneuroblastoma in 65-year-old male mimicking fibrous dysplasia. . E, F. Axial and coronal FDG-PET CT fused color images show intense FDG avidity in hyperostotic bones (blue arrows) indicating diffuse tumor infiltration. Uptake in thin rind of soft tissue mass could not be separately visualized.


Hyperostotic esthesioneuroblastoma in 65-year-old male mimicking fibrous dysplasia. G, H. Histologic images (H&E stains with 200 x . Shows predominantly reactive bone formation.


Hyperostotic esthesioneuroblastoma in 65-year-old male mimicking fibrous dysplasia. G, H. 400 x. Magnification). Demonstrates sheet of tumor cells (arrows) within reactive bone.


Scarring alopecia over scalp.


Non-scarring alopecia was present over the pubic region.


Multiple follicular-oriented papules over the abdomen and trunk.


Chest X-ray (posteroanterior view) shows bilateral diffuse micronodular infiltrates.


Computed tomography images demonstrate subcarinal adenopathy (asterisk) and diffuse ground-glass opacities with small nodules (arrows) which tend to be confluent in some areas of the lung (box).


Computed tomography images show complete resolution of lymphadenopathies and ground-glass opacities; only a few small nodules are detected (arrows).


Optical coherence tomography of the lesions of the right.


Left. Eye showing choroidal lesions causing elevation of the retinal pigment epithelium and subretinal fluid.


Showing a large well defined mass of 9.8 x 7.4 cms along with displacement of the bowel loops.


Intra operative finding of a large omental tumor in the left hypochondrium region with areas of ulceration.


Immunohistochemistry, 10 x 10 X shows tumor cells showing desmin positivity.


Immunohistochemistry 10 x 10 X shows tumor cells are negative for pancytokeratin.


(a) Day 1 - S.


Algae infected corneal ulcer measuring 2.7 x 4.2 mm (b) Day 1 - Corneal ulcer with fluorescein staining under cobalt blue light.


Day 22 - Resolving corneal ulcer with residual infiltrate.


Epithelial defect. Day 22 - Resolving corneal ulcer with fluorescein staining under cobalt blue light.


Week 18 - Central descemetocele.


Histopathology showed epidermal hyperplasia with hypermelanization and hyperkeratosis without columns of parakeratosis or cornoid lamella. H&E. x10.


(a, b) Color fundus photographs (montages) of the right and left eyes showing extensive chorioretinal atrophy along the vessels along with macular scarring.


(c, d) Autofluorescence images of the right and left eyes showing total loss of autofluorescence from the areas of chorioretinal atrophy.


(A)
Chlamydia psittaci detection in bronchoalveolar lavage fluid (BALF) using metagenomic next-generation sequencing (mNGS) on October 25, 2020.


Extent and location of exfoliated areas before debridement during primary treatment in the operating theater under general anesthesia (A).


Partial exposure of the dermis, epidermis separated with necrosis of basal keratinocytes, which turns into complete necrosis of the entire epidermis (100x magnification) (B).


Apoptotic bodies (arrowheads) were visualized in the epidermis collected from the affected area at different body locations (630x magnification) (C,D). All histological sections (2 x 2 mm) were prepared from formalin-fixed paraffin-embedded (FFPE) tissue specimens. Scale 20 mum.


Local image 3 months after application of lyophilized amniotic membrane - no signs of hyperpigmentation.


Medical image.


T1-gadolinium. MRI showing a cervical intramedullary tumor.


Histopathological study showed a schwannoma with biphasic components (hypercellular and hypocellular areas) (a).


Immunohistochemical studies showed strong reactivity for S-100 Protein (b).


Glial Fibrillary Acidic Protein (GFAP), Epithelial Membrane Antigen (EMA) and Progesterone Receptors (PR) were negative (c).


A low rate proliferative index was demonstrated by Ki-67 expression (d).


Postoperative T1-gadolinium MRI showing removal of IS.


Eruptive xanthoma in left lower extremity extensor.


Before treatment.


2 months after treatments.


Skin-colored nodules over the knuckles.


Linear IgA deposits in the basement membrane zone.


Isointense mass in T1-weighted image attached to the cord causing tethered cord. Notice the hypointense signal inside the expanded cord compatible with infected dermoid tumor found during surgery.


Hypointense mass in T2-weighted image is extending from distal cord through the bone defect to the extraspinal canal space and the prior MMC surgery field.


Pseudophakic pupillary block glaucoma, initial presentation (see text).


Pseudophakic pupillary block glaucoma, ultrasonogram. (a) Shows chain of low amplitude spikes in A-scan due to sterile vitritis (see text).


Pseudophakic pupillary block glaucoma, ultrasonogram. (b) Shows a bright anterior echo from intraocular lens (short arrow) followed by multiple reverberations (long arrow) in B-scan.


Pseudophakic pupillary block glaucoma: White pupillary membrane unearthed on mydriasis, still attached to iris superiorly but relieved inferiorly.


Pseudophakic pupillary block glaucoma: Slit lamp section shows pupillary membrane and superior iris bombe.


MRI imaging of the brain reveals diffusion restriction in the right medulla oblongata (red arrow) and an old infarction of the left cerebellum (white arrow).


Sicca keratopathy of the right eye seen as superficial punctate fluorescein staining of the corneal epithelium.


A list of all the signs and symptoms presented by our patient suffering a right-sided dorsolateral medullary infarction.


Dorsum of the tongue revealing violaceous to dark grey discoloration and blunted papillae in the centre with few tiny bright red erosions (black arrow) and interspersed white reticular lesions.


Mild desquamative gingivitis with gingival hyperpigmentation.


Longitudinal melanonychia of multiple. Fingers of the left hand.


Toes of the right foot. Pigmentation of the proximal and lateral nail folds is conspicuous.


Laparoscopic image of implants in the Douglas pouch.


Laparoscopic image of multiple peritoneal implants in the Douglas pouch.


Laparoscopic image of multiple peritoneal implants at the level of the omentum.


Surgical piece of the omentum.


(a and b) AP and lateral radiographs showing thoracolumbar instrumentation. As well as distal junctional deformity.


Expansion of the sacrum. Localized sacrum shows narrowing and remodeling of the walls of sacrum.


Sacral reconstructed C. T. Sagittal images showing expansion of the sacrum.


Sacral reconstructed C. Coronal images note enlargement of the sacral foramina.


Intraoperative photographs: (a) note protrusion of the tumor from the enlarged sacral foramina (white arrow heads).


(a) H-E 200 staining shows the cells arranged around vascular core containing blood vessels or pseudorosettes (black arrows), typical for MPE. (b) H-E higher magnification shows cells with anaplasia (black arrow heads), (c) note the tumor cells are diffusely reactive with glial fibrillary acidic protein, and (d) diffusely positive for S100 staining.


(a and b) Total spinal AP and lateral radiographs show persistent distal junctional disease (add-on) with no change in its degree.


(c) Photograph of the patient with no apparent deformity.


28-year-old man with a history of human immunodeficiency virus/acquired immunodeficiency syndrome complicated by numerous prior opportunistic infections, presented with progressive dyspnea and chronic, nonproductive cough, diagnosed with pulmonary Kaposi sarcoma. Scintigraphy demonstrating right greater than left lung delayed thallium uptake (panel a; black arrows) without corresponding gallium uptake (panel b).


28-year-old man with a history of human immunodeficiency virus/acquired immunodeficiency syndrome complicated by numerous prior opportunistic infections, presented with progressive dyspnea and chronic, nonproductive cough, diagnosed with pulmonary Kaposi sarcoma. Submandibular lymph node biopsy showing central sarcomatoid proliferation (hematoxylin and eosin, original magnification x100).


Pancreas acinar cell cystadenoma in 52-year-old man. . A. Contrast-material enhanced, coronal reformatted multidetector CT image. Multiple hypodense cystic lesions are clearly seen in pancreas (arrows).


Pancreas acinar cell cystadenoma in 52-year-old man. . B-D. Coronal half-Fourier acquisition single-shot turbo spin-echo (HASTE).


Pancreas acinar cell cystadenoma in 52-year-old man. . B-D. Axial precontrast.


Pancreas acinar cell cystadenoma in 52-year-old man. . B-D. Postcontrast T1 weighted. MR images of pancreas. Nonenhancing cystic lesions are seen in pancreas (arrows).


Pancreas acinar cell cystadenoma in 52-year-old man. . E. Image of macroscopic specimen. Numerous cysts with thin translucent wall are seen in body and head of pancreas.


Pancreas acinar cell cystadenoma in 52-year-old man. . F, G. Note small clusters of acinar cells forming acini that open into cyst lumens (G) (Hematoxylin & Eosin stain, original magnification, x 20 [F], 600 [G.


Histopathology examination of ulcer showing fungi with broad ribbon like morphology and fruiting bodies consistent with mucor.


Photograph showing left small finger. Arrow indicates triggering point of painful sensation on pressure.


Histological appearance of Vater-Pacini neuroma type B comprising a grape like cluster of VP corpuscles embedded in adipose and connective tissue. Note that neurofibroma is present. H&E stain, scale 500 microm.


Magnetic resonance imaging scan of brain in T2 sequence showed non-enhancing altered signal intensity in both thalamic and left medial temporal lobe suggestive of encephalitis.


Magnetic resonance imaging brain in T2 fluid attenuation inversion recovery sequence showed bilateral symmetrical hyperintensities in both thalamic regions.


Magnetic resonance imaging scan of brain T2 fluid attenuation inversion recovery sequence showed altered signal intensity in both thalamic and splenium of corpus callosum region.


Erythematous plaques over the face at presentation.


Erythema over finger tips at presentation.


Fite stain showing acid-fast bacilli (marked with arrow).


Two months post-treatment with antileprosy therapy showing resolution of facial plaques.


Pre-operative photograph of the patient showing the characteristic faecies.


Pre-operative intraoral photograph showing absence of both upper and lower alveolus and complete anodontia.


Three dimensional skull model of the patient used to assess the height and the width of the required upper and lower alveolus.


Postoperative intraoral photograph showing the overdentures.


Postoperative OPG showing the reconstructed upper and lower alveolus (free fibula) and the dental implants.


Postoperative photograph of the patient.


Numerous irregular infected ulcers of the right lower extremity.


Extensive ulcers partially covered with necrotic tissue in the left lower extremity.


Eczema of the left thigh.


Giant nevus encompassing the lower abdomen, genital area, and upper thighs.


Giant nevus involving the middle and lower back, gluteal region, and upper thighs. Numerous smaller satellite nevi are also observed on the neck, upper back, and upper limbs.


CT scan before radiotherapy: local recurrence of melanoma, 36.80 x 26.78 mm in size, in the nasal cavity (A).


MRI at 2 months after IMRT treatment: regression of the tumor (B).


PET-CT image: metastasis at the scapula before.


After. Combination therapy.


Cut-surface of the mass shows whitish, nodular, round, glistening areas with yellow-brown soft areas in the centre.