A 48-year-old man developed right lower quadrant pain and was taken to the operating theater. A ruptured appendix was associated with widespread mucinous tumor within the peritoneal space. He was treated with 5-fluorouracil plus leucovorin chemotherapy. Seven years after the appendectomy a repeat CT scan shows a 7 cm in diameter cystic mass within the central portion of the spleen.


Right unilateral periorbital oedema.


Angiosarcoma (on the right) adjacent to SCC (on the left) with intervening normal sebaceous glands. The tumour consists of irregular anastomosing channels lined by markedly pleomorphic cells. The vessels dissect through the dermis, and the tumour is poorly circumscribed. This is a relatively well-differentiated area, so you can see the obvious vascular nature of the tumour.


ERG showing the tumour dissecting through the dermis into the subcutaneous fat. Note the above SCC does not stain for this marker, allowing clear distinction.


Contrast enhanced axial abdominal CT demonstrating primary epiploic appendagitis adjacent to the sigmoid colon 7 months prior to presentation.


Longitudinal abdominal CT with contrast enhancement demonstrating primary epiploic appendagitis adjacent to the sigmoid colon 7 months prior to presentation.


En-face optical coherence tomography angiography (OCTA) montage of the left eye of a 25 year old man with a combined hamartoma and subfoveal vitelliform lesion incorporating a 4.5 x 4.5 mm scan of the peripapillary area, a 6 x 6 mm scan of the macula, and a higher resolution 3 x 3 mm scan of the fovea. Segmentation of all scans includes the full thickness of the neurosensory retina. The flow signature corresponding with the small vessels of the hamartoma has a disorganized morphology. Tractional effects and distortion of the foveal avascular zone are also appreciated.


Head CT showing intracerebral hemorrhage and a calcified lesion.


3D angioTC showing the aneurysm.


Lesion in the right alveolar ridge of the mandible with bone reabsorption; Presence of a cervical enlarged lymph nodes.


Enlarged lymph node (12.


8 mm) visible in the CT scan with correspondent abnormal in FDG uptake in the PET.


Focus of increased uptake in multiple mediastinal and hilar lymph nodes.


Chest x-ray on admission showing consolidation with thin airbronchogram in the right upper lobe.


Spiral (unenhanced) abdominal CT demonstrated thickening of small bowel in several loops, haziness of the mesentery and ascitic fluid collection.


Mild thickening of the distal ileum mucosal folds demonstrated by MRI enteroclysis (3 months after the episode and still under corticosteroids) with true-FISP sequence in coronal plane.


Magnetic resonance imaging abdomen showing absent uterus and vagina. Absent left kidney. Grade-I spondylolisthesis with bilateral spondylosis at L5-S1 level.


Magnetic resonance imaging abdomen - Visualization of gonads with features s/o of ovary at both para iliac region.


Karyotype study shows (46, XX) chromosome.


Computed tomography brain shows dandy walker malformation with vermian hypoplasia. Partial agenesis of corpus callosum and colpocephaly with obstructive hydrocephalus.


X - ray skull showing macrocephaly.


CMR showing endocardial involvement of inferior and inferolateral wall as well as inferior septum.


TTE, apical 4 chamber view with obliteration of apex of left ventricle from endocardium thickening and thrombus.


Bone scan of bilateral tibae demonstrates focal increased radiotracer uptake along the medial aspect of the left tibia at the concavity of the curve.


Radiograph of the leg. Third month after biopsy: Note the worsening cortical lysis with apathological fracture of the tibia.


Paperclips.


A selection of pelvic radiographs demonstrating FBs inserted into the patient's urethra, including parts of pens , glass.


Dismantled suprapubic catheter FBs, foreign bodies.


Showing the Isiris. with monitor.


Computed tomographic scan of abdomen showing pseudomyxoma peritonei with multiple peritoneal masses (arrow) with "scalloping effect. ".


Laparotomy with right oophorectomy, omentectomy, and pseudomyxoma debulking.


Yellow-orange gelatinous material.


Hematoxylin and eosin staining (x20).


Cytokeratin 7 focally positive staining (x10).


Cytokeratin 20 diffusely positive staining (x10).


Abdomen ultrasonography showing a mass with 58 x 30 mm in the left parietocolic groove.


Abdomen ultrasonography showing a ganglion with 32 mm at hepatic hilum.


Matted lymph nodes in the right inguinal region. Discharging sinus and healed scars on the left side.


Mantoux test showing highly positive reaction with induration measuring 25 mm.


Complete resolution of bilateral buboes with antituberculous treatment.


String test result for Klebsiella pneumoniae. Stretching of K. pneumoniae colonies isolated from our patient's sample resulted in the formation of a string >5 mm in length, demonstrating the hypermucoviscosity phenotype.


Abdominal Computed Tomography (CT) scan images a) CT showing a 15 cm diameter liver abscess with internal septa and irregular margins.


CT hypodensity tumour like lesion with narrowing of the gastric lumen (gastric abscess).


Endoscopy showing submucosal mass.


Endoscopy-ultrasound demonstrating a 3-cm well circumscribed hypoechoic submucosal mass suggestive of intramural abscess.


Images obtained a week after the operation. A T2-weighted axial MR image. B; Arrow indicates that satisfactory CSF flow through aqueduct of Sylvius is detected. Indicates the fenestrations of the apical membrane (f1 and f2).


Images obtained a week after the operation. A T2-weighted axial MR image. C;. Indicates two fenestrations of the basal cyst membrane behind the midline (f3 and f4).


Case presentation 1. Clinical presentation.


Case presentation 1. Clinical presentation, detailed view of the suspected lesion.


Case presentation 1. Dermoscopic picture of seborrheic keratosis.


Case presentation 1. Dermoscopic picture of the pigmented BCC.


Case presentation 2. Clinical presentation.


Case presentation 2. Dermoscopic picture of solar lentigo.


Case presentation 2. Dermoscopic picture of seborrheic keratosis.


Case presentation 2. Dermoscopic picture of the lentigo malignant melanoma.


Initial axial CT at the mid-abdominal level reveals no infiltration of the greater omentum and absence of ascites.


Follow-up axial CT of the abdomen confirms the tumorous infiltration of the greater omentum (known as omental cake, arrow) and ascites (arrowhead), as could be seen on the preceding ultrasound.


Sagittal reformation of the middle abdomen demonstrates the diffuse infiltration extending from the right pleural space (arrow) and abdominal cavity. Infiltration of the greater omentum can be seen with typical confirmation of the omental cake (curved arrow). Additionally, free infradiaphragmatic fluid is depicted (arrowhead).


Aspiration of ascites shows atypical mesothelial cells, originating from the primary tumor in the right pleura, consistent with malignant secondary peritoneal mesothelioma.


Histological analysis (HE staining) shows infiltrating malignant mesothelioma (arrows) within the greater omentum. In combination with the cytological results, secondary peritoneal mesothelioma, originating from the previously diagnosed pleural mesothelioma with infiltration of the abdominal space, was confirmed.


Right Foot edema with peripheral Cyanosis.


Right Forefoot Gangrene.


Chronological summary. IOP, intra-ocular pressure.


Optical coherence tomography pachymetry 8 months after the procedure.


MRI LS spine showing organised iliopsoas abscess before treatment.


MRI LS spine showing resolution of organised iliopsoas abscess after treatment.


Crops of small, red-yellow dome-shaped papules of approx. 6 mm with well-defined borders located on the anterior medial thigh.


Appearance of venous blood following phlebotomy, exhibiting a thick, milky supernatant.


An axial view of a non-contrast computed tomography scan showing multiple areas of acute and subacute ischemic strokes in different territories.


An axial view of computed tomography angiography scan showing a donut sign in the left vertebral artery, suggestive of free-floating thrombus at the level of V1.


A coronal view of computed tomography angiography scan showing a long, fresh, free-floating thrombus in V1 and V2.


A coronal view of computed tomography angiography scan, showing complete canalization of the thrombus in the left vertebral artery 7 days post initiation of therapy.


Alopecia and hair loss identified in patient with CCS.


Hyperpigmentation of the hands and fingers are present in this case.


Onychodystrophy and atrophic nail change in patient with CCS.


Operative findings. (a) An image obtained before drilling the clival recess.


Operative findings. The patient underwent ETSS, (b) After removing the mucosa of the sphenoid sinus, the clival bone was drilled to entirely expose the mass.


Operative findings. The gelatinous and yellowish-brown mass mainly located in the extradural space,. The mass is partially located intradurally accompanied with a small dural defect.


Operative findings. An image obtained after removal of the mass. The mass is partially removed and decompression is performed. OCR = opticocarotid recess, CP = carotid protuberance, EP = ecchordosis physaliphora, BA = basilar artery.


Postoperative gadolinium-enhanced axial T1-weighted MRI obtained 1 week after surgery revealing a residual mass on the right Dorello's canal (arrow).


Gadolinium-enhanced axial T1-weighted MRI obtained 4 months after surgery does not reveal a residual mass (arrow head).


Laparoscopic dissection of adiposes cleavage planes with the left colon and the others surrounding peritoneal organs.


Retroperitoneal space after surgical resection: we can identify spleen and preserved pancreatic tail, clipped left renal vein and artery.


Surgical specimen with in block resection of left kidney, adrenal gland and DD liposarcoma.


DD liposarcoma appeared oval, 13 x 11 x 9 cm of size, with a smooth surface and regular margins.


Excision and grafting of the axillary area, with a favorable evolution after Hurley stage III suppurative hidradenitis.


Hurley stage III suppurative hidradenitis, affecting the groin, scrotal, perineal, inner thighs.


Favorable evolutionary fasciocutaneous flaps under VAC treatment and protection of the perineal area by colostomy. The post-fasciotomy scar is also observed on the right leg.


Hyperplasia of the epidermis and the presence of a fistulous tract lined with granulation tissue and hemorrhage (HE stain, x40).


Polymorphic inflammatory infiltrate with polymorphonuclear, lymphocytes, plasmocytes and multinucleous extracellular giant cells (HE stain, x200).


Hemato-fibrino-leukocyte exudate on the surface and fibrosis on the wall (HE stain, x40).


Bilateral axillary hidradenitis, Hurley stage II.


Suppurative hidradenitis in the groin and perineal.


Psoriasis lesions on the elbows and back.


Dextroconvex dorsolumbar scoliosis and L5 spondylolysis.


Thickened epidermis, edema, hemorrhagic exudate, inflammatory polymorphic infiltrate (HE stain, x40).


Areas with inflammatory polymorphic infiltrate, with relatively numerous eosinophils throughout the dermis (HE stain, x100).


Photograph of patient's lower leg with tender, cool, indurated nodules 2 cm superior to medial malleolus.


Histopathology demonstrating granulomas in subcutaneous fat. (H&E staining. Original magnification x100).


(a) Preoperative view of patient at time of presentation.


(b) Preoperative mouth opening of the patient = 15 mm with mild deviation of the mandible to the injured (right) side.


Waters' view revealed loss of normal architecture of the coronoid process and zygomatic arch on the right side (red circle). Left zygomatic arch is fairly visible.


Mouth opening after 6 months = 40 mm.


(a-c) Computed tomogram taken 1 month after surgery showing level of resection and gap between roof of the glenoid fossa and the mandible and also reconstructed zygomatic arch secured with miniplates.


Case of mycosis fungoides: Closer facial view.


Case of mycosis fungoides: Far view.


Right periorbital swelling and ptosis, and severe chemosis were observed in the initial presentation.


Non-contrast orbital CT scan revealed periorbital tissue infiltration and right orbital edema (arrows). A; Axial view shows muscular thickening of the right lateral rectus muscle.


Non-contrast orbital CT scan revealed periorbital tissue infiltration and right orbital edema (arrows). B; Coronal view shows right periorbital swelling and mucoperiosteal soft tissue attenuation in the left maxillary sinus.


Right lid swelling, chemosis, corneal edema, and orbital inflammation resolved 2 weeks after the onset.


Multimodal imaging at the initial visit. (A) Fundus examination of the left eye shows an isolated off-white lesion near the macular area and a large level of muddy-like exudate above the macular area.


Multimodal imaging at the initial visit. (B) An enlarged image of the lesion.


Multimodal imaging at the initial visit. (C) OCT imaging shows off-white lesions on transverse scanning; the lesions are bright on the outside and black on the inside with an oval ring reflection (bold green arrow), strong point reflection between layers, and edema between layers.


Multimodal imaging at the initial visit. (D) OCT-A shows sparse blood vessels, superficial vascular dilatation, and a tangled nodule beside the vessels.


Multimodal imaging at the initial visit. (E) Enlarged OCT-A image.


Multimodal imaging at the initial visit. (F,G) The fundus and OCT of the right eye are normal.


One month after the second MPL treatment. (A) Fundus examination of the left eye shows muddy-like exudation above the macular area and that the off-white lesions had shrunken.


One month after the second MPL treatment. (B) OCT shows that the oval structure in macular area had become more solid and that the cavity structure had disappeared.


One month after the second MPL treatment. (C,D) FFA shows strong fluorescent light spots near the macular area in the early stage and slight leakage in the later stage.


One month after the second MPL treatment. (E,F) ICGA shows a light spot near macular area in the early stage, and there was no leakage in the later stage.


Diffuse old scars of pyoderma gangrenosum on the lower extremities.


Immunologcal findings. DIF shows. Immunoglobulin G (IgG).


Immunologcal findings. Complement 3 (C3) deposition along the cell surface of keratinocytes.


Immunologcal findings. (C) Results of immunoblotting of normal human epidermal extracts. Pemphigus vulgaris (PV) control serum reacted with the 160-kDa desmoglein (Dsg) 1 and the 130-kDa Dsg3 (lane 1), paraneoplastic pemphigus (PNP) control serum reacted with the 210-kDa envoplakin and the 190-kDa periplakin (lane 2), bullous pemphigoid (BP) control serum reacted with the 230-kDa BP230 and the 180-kDa BP180 (lane 3), anti-desmocollin (Dsc) monoclonal antibody (mAb) (lane 4) and the patient serum (lane 5) reacted strongly with the 110-kDa a-form and the 100-kDa b-form Dsc3. DIF: direct immunofluorescence.


Preoperative and postoperative findings by MRI and CT. . Notes: (A) Preoperative MRI scan showing the tumor located in the left part of the ventral medulla oblongata.


Preoperative and postoperative findings by MRI and CT. (B) Postoperative day 1 CT scan showing no apparent ischemic infarct area.


Preoperative and postoperative findings by MRI and CT. (C) Postoperative day 3 CT scan showing an ischemic infarction at the bilateral internal carotid arteries and the posterior cerebral artery.


Preoperative and postoperative findings by MRI and CT. (D) Postoperative day 3 MRA showing stenosis in the siphon segment of the bilateral internal carotid arteries and distal segment of basilar artery, and the slender distal blood vessel. Cerebral artery showed a slender, segmental stricture.


Preoperative and postoperative findings by MRI and CT. (E) Postoperative CT scan showing the progressively enlarged ischemic infarction area.


Preoperative and postoperative findings by MRI and CT. (F) Postoperative CT scan showing decompressive craniectomy. . Abbreviations: CT, computed tomography; MRA, magnetic resonance angiography; MRI, magnetic resonance imaging.


Photomicrograph of the tumor specimen. . Note: Pathological examination was consistent with a schwannoma.


Torpedo maculopathy. A; June 2010, fundus photography OS in a 15-year-old male. The magnified view shows the torpedo lesion, with the proposed origin of the pseudo-lacuna demonstrated by the arrow.


Torpedo maculopathy. B; October 2015, fundus photography OS in a 15-year-old male. The magnified view shows the torpedo lesion with a markedly larger pseudo-lacuna demonstrated by the arrow.


EDI-OCT of torpedo maculopathy taken in October 2015. A; Scan at the level of the 'pseudo-lacuna' within the torpedo lesion. The white arrow corresponds to the location of pseudo-lacuna in both the infrared image on the left and the OCT image on the right.


EDI-OCT of torpedo maculopathy taken in October 2015. B; The white arrow demonstrates a subretinal cleft through the torpedo lesion.


Fundus autofluorescence of OS in October 2015. The pigmented torpedo lesion is hypoautofluorescent with a rim of hyperautofluorescence. There is a small dot of hyperautofluorescence that corresponds to the pseudo-lacuna found on the color photo (white arrow).


FA of OS in October 2015. A; The early-phase angiogram demonstrates a globally hypofluorescent lesion with a rim of hyperfluorescence and no neovascular activity.


FA of OS in October 2015. B; The late-phase angiogram confirms no neovascular disease or leakage. The area signified by the pseudo-lacuna lesion (arrows) remains hypofluorescent.


Clinical course of the patient during the first admission. A: Initial clinical appearance. The anterior surface of the trunk exhibits a deep burn.


Clinical course of the patient during the first admission. B: Appearance after the first series of debridement and skin grafting.


Clinical course of the patient during the first admission. C and D: Multiple ulcers in the grafted skin and donor sites.


Scabies masquerading as bullous pemphigoid. . Notes: The chest and abdomen of a 76-year-old man show the new appearance of pruritic pinkish-red dermal plaques. Angiomas, present as dark red nodules, are also numerous.


Bullous scabies mimicking bullous pemphigoid. . Notes: A closer view of the scabies lesions presenting as pink-red plaques on the left upper abdomen that mimic the urticarial phase of bullous pemphigoid. Biopsy showed a superficial and deep inflammation containing numerous eosinophils.


Scabies surrepticius masquerading as bullous pemphigoid. . Notes: A closer view of the scabies lesion on the right lower abdomen; it presents as a tense blister. Biopsy showed a sub-epidermal blister with eosinophils not only in the papillary dermis beneath the base of the vesicle, but also in the superficial and deeper dermis.


OCT of the right eye showing multiple hemorrhagic PEDs with notch (arrow) and underlying polyps (arrow head) surrounded by SRF.


(a) Coronal view of the gadolinium-enhanced early postoperative brain magnetic resonance imaging. There is a small shell of tumor remnant (a: asterix) at the floor of the third ventricle abutting the hypothalamus.


Sagittal section of the left side of the sellar region showing that the pituitary stalk. Arrow), and . Gland. Asterix) have been well preserved.


Right hand: Note gross swelling in the first web space and clubbing of the nails.


Panoramic radiograph showing well defined periradicular radiolucency.


Infrared fundus photo and OCT of the left eye with hyperreflective plaques at the level of the OPL/ONL junction, with associated disruption of the inner segment/outer segment junction (ellipsoid zone).


A 4.0x4.5 cm, hard, round, protuberant tumor was found on the right palm.


The tumor cells had eccentric nuclei and round and deeply eosinophilic cytoplasms with inclusion bodies, displaying a rhabdoid appearance.


Immunohistochemically the tumor cell were positive for S100 and EMA.


On CT scan, chondral erosions can be seen posterior to the elbow joint in axial sections with arrow. . Abbreviation: CT, computerized tomography.


On MR imaging, hyperintense, well-defined, nodular mass lesions can be seen in fat suppression sequences (arrows). . Abbreviation: MR, magnetic resonance.


(a-c) Photomicrographs with H&E staining demonstrating the cytoarchitecture of the tumour with hypercellular and hypocellular myxoid areas. The cellular areas are composed of spindle shaped cells having mildly pleomorphic elongated nuclei. Scattered eosinophilic globules with few microtubules are seen as well.


Magnetic resonance imaging brain without contrast showing immediate post op images demonstrating maximum safe resection of the tumor.


Histopathological findings of lesional skin biopsy showing intraepidermal spongiform pustule consisting of accumulated neutrophils in an acanthotic, hyperkeratotic and parakeratotic epidermis. The dermis showed a sparse perivascular mixed inflammatory infiltrate (x100, hematoxylin and eosin [H&E]).


Clinical presentation of the patient 21 days after the initial photographs were taken. Dramatic improvement of the lesions 2 weeks after the first infusion of infliximab and 3-week treatment with acitretin (A and B).


Lymphangiectasis of the vulva with deep-seated vesicles.


Inguinal scars in the left groin.


After two sessions of treatment.


(a) Preoperative plain film showing an expansile osteolytic lesion in the left second metacarpal bone.


(b) Immediate postoperative plain film revealing a bone defect with a hyperdense mass.


(c) Three-year postoperative plain film showing consolidation and remodeling of the bone lesion without fracture.


(a) Illustration of left second metacarpal bone showing metastatic adenocarcinoma composed of infiltrating nests of pleomorphic polygonal cells with focal glandular formation and intracytoplasmic vacuoles.


(b) Tumor cells of the metastatic lesion (metacarpal bone) are immunoreactive for thyroid transcription factor-1 with nuclear staining.


(c) Tumor cells of the metastatic lesion (metacarpal bone) are immunoreactive for cytokeratin 7 with cytoplasmic staining.


(d) Histologically, the left lower lung shows features of adenocarcinoma similar to the metastatic lesion.


External clinical photograph. Cystic mass in the upper lip.


Fine-needle aspiration cytology showing many anucleated squames and few benign nucleated squamous cells in a dirty background (May-Grunwald-Giemsa, x100).


Photograph of a child showing freckles, cachexia, sunken eyes and sparse hair.


MRI showing enlargement of 4th ventricle and atrophy of vermis.


(a and b) Sagittal T2-weighted MRI scans taken at the time of presentation show a slightly hyperintense heterogeneous mass at the level of T8-T9.


(c and d) T1-weighted MRI scans taken after gadolinium administration show a hypointense mass with circumferential enhancement.


Axial T1.


T2. Images show an extramedullary intradural dumbbell-shaped mass.


Intraoperative view of the dark, dumbbell-shaped tumor with apparent hemorrhage within the dural sac near the left T8 spinal nerve.


Sagittal.


Axial. T2-weighted MRI images taken 2 months after the removal of a spinal MS tumor.


IVP Findings; A Small Round Shape Mass Near to Trigon Which Was Prolapsed Into Bladder.


Pathologic Figures.


A. The hemorrhaging tumor was located in the RA, SVC, and IVC.


B. After resecting the tumor.


C. Reconstruction with pedicled autologous pericardium.


Enhanced computed tomographic scan showed the right atrial wall lumen was not narrowed. Pleural and pericardial effusion are observed.


Perineal lesions.


Melanotic granules expressed out from the lesions.


Madurella mycetomatis in Sabouraud's dextrose agar (two cultured specimens of patient) with leathery colony and brown pigment production compared with control.


(a) Angiography: severe stenosis of the left carotid artery.


(b) Angioplasty with stenting - final result.


Surgery: a saphenous vein graft was placed between the common and the internal carotid arteries. The pseudoaneurysm was isolated with a vascular clamp across the proximal common carotid artery and a clip was placed in the internal and external carotid arteries.


Postoperative MRA of the cervical vessels showing the patency of the graft in the left side.


(A, B) Hematoxylin and eosin staining; magnification x100 and x200, Duct cells are observed in the loose stroma.


(C, D) Hematoxylin and eosin staining; magnification x100 and x200, Urachal mucinous adenocarcinoma, groups of tumour cells surrounded by extracellular mucin.


Timeline of the Serum marker.


A largxe adrenal medullary mass. (a) Mass on upper pole of kidney.


A largxe adrenal medullary mass. (b) Cut section: Grayish yellow hemorrhagic mass compressing adrenal cortex superiorly and kidney lie on the either sides.


Photomicrograph (a) zellballen nest pattern of tumor cells with hemorrhage and cystic change. X100) (b) bizarrely pleomorphic tumor cells with prominent nucleoli, and ,intranuclear inclusions, and . Amphophilic granular cytoplasm. X400).


Radiology imaging of the patient and immunostaining for TSH in the pituitary tumor. (A) Preoperative magnetic (MR) resonance image (T1-weight, sagittal view). White arrow pointing to a less enhanced area in the sella (17 x 15 mm, arrow), involving the cavernous sinuses.


Radiology imaging of the patient and immunostaining for TSH in the pituitary tumor. (B) Preoperative magnetic (MR) resonance image (T1-weight, coronal view).


Radiology imaging of the patient and immunostaining for TSH in the pituitary tumor. (C) Postoperative MR image (T1-weight, sagittal view).


Radiology imaging of the patient and immunostaining for TSH in the pituitary tumor. (E) Radionuclide (99mTcO4) scan showed diffusely increased uptake, the ratio of uptake of the tracer in the thyroid to that in the background was 45 (right lobe) and 40 (left lobe).


Radiology imaging of the patient and immunostaining for TSH in the pituitary tumor. (F) Positive immunostainning for TSH in the pituitary tumor (magnification 400 x).


63-year-old man with angiosarcoma of the scalp. Low power. X100).


63-year-old man with angiosarcoma of the scalp. High power. X400).


63-year-old man with angiosarcoma of the scalp. Hematoxylin-eosin stain shows pleomorphic endothelial cells, and immunohistochemical staining (C, x400) shows positive for CD31 antibody staining.


Coronal view of T2.


Contrast enhanced T1. Weighted MR image shows a diffuse thickening of the scalp, invading subcutaneous fat with reticular patterns of high signal intensity (asterisk) due to angiosarcoma. Superficial fascia (arrows) shows diffuse thickening and enhancement, covering normal signal intensity of temporalis muscles (small arrow).


Sagittal view of T2.


Contrast enhanced T1. Weighted image show tumor involvement of superficial fascia (arrows), overlying the occipital belly and galea aponeurotica (arrowheads).


Color coding image according to signal intensity of coronal.


Sagittal. Views of T2 weighted MR image demonstrate the occipital belly of the occipitofrontalis muscle becomes the red colored galea aponeurotica (arrow head) and inserts into the underside of the green colored superficial musculoaponeurotic system (arrows), composed of the frontal belly of occipitofrontalis and temporoparietal fascia. Ga : galea aponeurotica, fb : frontal belly, ob : occipital belly, tpf : temporoparietal fascia.


PET-CT show diffuse uptake in the scalp (arrowheads) but invisible increased uptake on epicranial muscle (A).


Faint uptake is visible in lymph nodes (arrows) at the level VA (B).


On the 6 months follow-up PET-CT, hot uptake were visible in the level VA lymph nodes (arrow) which showed faint uptake initial study.


Multiple lymph node metastases of both neck (arrows) are seen.


Gray-scale ultrasound images (a, b) show hypoechoic areas (yellow arrowhead), with intra-lesional vascularization on color flow Doppler examination, near the dorsal surface of the both corpora cavernosa.


CT images through the. Lung.


Liver demonstrate multiple metastatic lesions.


Preoperative T1-weighted MRI with contrast enhancement in. Sagittal.


Axial.


Coronal view, showing massive midline shift to the right due to widespread, plaque-like lesions purely restricted to the left cerebral hemisphere.


Follow-up MRI 3 months postoperatively, showing in a coronar T1 view with contrast enhancement residual tumors at the lateral and medial sphenoid wing.


A) Arterial phase CT scan. Multiple cysts (arrow) which replace pancreatic parenchyma.


B) Magnetic resonance imaging, T1 weighted sequence, without contrast demonstrates hypointense focal images and others of different sizes which are hyperintense (arrows).


C) The T2 weighted sequence shows hyperintense cystic focal images and others which are heterogeneously hyper and hypointense consistent with the image descriptions in B (arrow).


D) Cholangioresonance shows dilatation of the bile duct with a blockage in the intrapancreatic bile duct and the disappearance of the Wirsung duct by replacement of the pancreatic parenchyma by the tumour.


Endoscopic Ultrasound (EUS). A) Hypoechoic heterogeneous mass, with irregular borders, located in the head of the pancreas.


Endoscopic Ultrasound (EUS). B) Observe the distal end of the biopsy needle entering the tumour (yellow arrow).


Bilateral Upper limb webbing (Pterygia).


Webbing involving only anterior axillary fold.


Multiple Z plasty.


Early post op. result.


Molecular findings: (A) Electropherogram showing the variation in ERCC4 gene in exon 8 (c.1762 G>T p. V588F) at a homozygous state in the patient XP21.


(B) Electropherogram showing double variation in DDB2 gene (c.613 T>C p. C205R and c.618 C>A p. S206R) in exon 5 in XP134 patient.


(C) Structures of the XPF protein and F588 XPF mutant suggesting a mild distortion in helix domain.


(D) DNA DDB2 protein interaction for muted DDB2 protein suggestion that R206 affect this process.


A tense, blood-filled bullae on the tongue.


Subepithelial blister and a few inflammatory cells seen in routine hematoxylin and eosin section (10x). . The subepithelial space was filled with erythrocytes.


Operative findings, showing. The anconeus epitrochlearis muscle (arrowhead) compressing the ulnar nerve (arrow).


A ganglion (arrowhead) compressing the ulnar nerve (arrow).


Macroscopic feature of the partial penectomy showing a large exophytic mass with an irregular surface.


Macroscopic cross-section of the partial penectomy showing a gray, white and congestive tissue. Scale bar = 70mm.


Two live dirofilarial worms.


Microscopic picture of the worm showing Cuticle and transverse striation.


Posterior view of distal forearm and hands shows increased uptake in the phalanges, distal ends of metacarpals, radius and ulna.


Anterior view of feet and lower limb on a Tc-99m MDP bone scan shows pericortical uptake in the distal ends of tibia and fibula. Prominent uptake in distal ends of 1st metatarsal and phalanges of both feet is also seen.


Posterior view of both lower limb and feet showing increased uptake at the distal ends of tibia and femur bilaterally with increased pericortical uptake at distal ends.


Whole body bone scan with normal chest anterior and posterior view and normal axial skeleton.


Histopathological examination with dense aggregates of inflammatory cells comprising predominantly of plasma cells (H&E, 40x).


A 46-year-old male presented with chest pain for 1 month. Frontal chest radiograph shows a homogenous radio-opacity in the left upper zone, broad based toward aortic knuckle (large white arrow) causing superior mediastinal widening.


(a-c) A 46-year-old male presented with chest pain for 1 month. Multidetector computed tomography thoracic aortography (axial, sagittal, and coronal sections in mediastinal window) shows focal intense enhancing saccular outpouching (pseudoaneurysm) in the inferolateral wall of aortic isthmus, mushroom shaped (*) just distal to origin of the left subclavian artery (small white arrow) with periaortic hypoattenuating prominent inflammatory soft tissue (large white arrow) causing subsegmental passive collapse of the left upper lobe (white arrowhead).


(a) A 46-year-old male presented with chest pain for 1 month. Multidetector computed tomography (MDCT) thoracic aortography - three-dimensional (3D) volume rendered (VR) image (axial) shows focal saccular outpouching (pseudoaneurysm) in the inferolateral wall of aortic isthmus, mushroom shaped (white arrow) just distal to origin of the left subclavian artery.


(b) A 46-year-old male presented with chest pain for 1 month. MDCT thoracic aortography - 3D VR image (sagittal) shows focal saccular outpouching (pseudoaneurysm) in the inferolateral wall of aortic isthmus, mushroom shaped (large white arrow) just distal to origin of the left subclavian artery (small white arrow).


(c) A 46-year-old male presented with chest pain for 1 month. MDCT thoracic aortography - 3D multidetector computed tomography image (coronal) shows focal saccular outpouching (pseudoaneurysm) in the inferolateral wall of aortic isthmus, mushroom shaped (large white arrow) just distal to origin of the left subclavian artery (small white arrow).


(a and b) A 46-year-old male presented with chest pain for 1 month. Multidetector computed tomography thoracic aortography, (axial sections in mediastinal window) shows few para-aortic necrotic lymph nodes (white arrowhead), few left lower paratracheal partially necrotic lymph nodes (small white arrow), and few aortopulmonary or subaortic partially necrotic lymph nodes (large white arrow).


A 75-year-old male presented with dyspnea, right-sided chest pain, massive hemoptysis, and fever. Frontal chest radiograph shows a fairly defined inhomogeneous radio-opacity in the right upper and mid zones lung fields (large white arrow).


(a) A 75-year-old male presented with dyspnea, right-sided chest pain, massive hemoptysis, and fever. Multidetector computed tomography (MDCT) pulmonary arteriography - three-dimensional (3D) volume rendered (VR) image (axial) shows focal saccular outpouching (pseudoaneurysm) arising from the feeding posterior segmental branch of the right pulmonary artery (white arrow).


(b) A 75-year-old male presented with dyspnea, right-sided chest pain, massive hemoptysis, and fever. MDCT pulmonary arteriography - 3D VR image (coronal) shows focal saccular outpouching (pseudoaneurysm) arising from the feeding posterior segmental branch of the right pulmonary artery (white arrow).


(c) A 75-year-old male presented with dyspnea, right-sided chest pain, massive hemoptysis, and fever. MDCT pulmonary arteriography - 3D VR image (sagittal) shows focal saccular outpouching (pseudoaneurysm) arising from the feeding posterior segmental branch of the right pulmonary artery (white arrow).


(a) A 75-year-old male presented with dyspnea, right-sided chest pain, massive hemoptysis, and fever. Immediate postoperative follow-up frontal chest radiograph shows coils filling the pseudoaneurysm sac (small white arrow) with minimal resolution of inhomogeneous radio-opacity (white arrowhead).


(b) A 75-year-old male presented with dyspnea, right-sided chest pain, massive hemoptysis, and fever. Post-operative day 3 follow-up frontal chest radiograph shows coils filling the pseudoaneurysm sac (small white arrow) with partial resolution of inhomogeneous radio-opacity (white arrowhead).


(c) A 75-year-old male presented with dyspnea, right-sided chest pain, massive hemoptysis, and fever. Four weeks post-operative follow-up frontal chest radiograph shows coils filling the pseudoaneurysm sac (small white arrow) with near-complete resolution of inhomogeneous radio-opacity (white arrowhead).


A 43-year-old male presented fever, pain, and localized swelling in the right upper anterior chest wall for 1 month. Frontal chest radiograph shows no significant abnormality.


(a-c) A 43-year-old male presented fever, pain, and localized swelling in the right upper anterior chest wall for 1 month. Contrast-enhanced computed tomography chest (axial, coronal, and sagittal sections in mediastinal window) shows a fairly defined peripherally enhancing collection in the right upper anterior chest wall epicentered in 1st costochondral junction and sternocostal joint (small white arrow). Adjacent encasement of the right internal mammary artery with pseudoaneurysm of the artery is seen (large white arrow).


(a) A 43-year-old male presented fever, pain, and localized swelling in the right upper anterior chest wall for 1 month. Contrast-enhanced computed tomography (CT) chest - three-dimensional (3D) volume rendered (VR) image (axial) shows focal saccular outpouching (pseudoaneurysm) of the right internal mammary artery (large white arrow).


(b) A 43-year-old male presented fever, pain, and localized swelling in the right upper anterior chest wall for 1 month. Contrast-enhanced CT chest - 3D VR image (coronal) shows focal saccular outpouching (pseudoaneurysm) of the right internal mammary artery (large white arrow).


(c) A 43-year-old male presented fever, pain, and localized swelling in the right upper anterior chest wall for 1 month. Contrast-enhanced CT chest - 3D VR image (sagittal) shows focal saccular outpouching (pseudoaneurysm) of the right internal mammary artery (large white arrow).


Liver biopsy showing mild steatosis with ballooning cells and some glycogenated nuclei (A, B).


In the centrilobular zone, the reticulum stain highlights fibrosis (C).


Numerous CD68+ and PAS/diastase+ macrophages are also present (D).


Caseified granulomas containing epitheloid cells, and Langhans-type giant cells (H&E x 40).


Magnetic resonance imaging spine axial plane: A homogeneously enhancing intradural extramedullary mass lesion was seen at C4/5 level with extension in to the right C4 neural foramina causing widening of the foramen. The spinal cord was severely compressed and displaced to the left side.


(a and b) Intraoperative appearance of the tumor. Mark 1: Cut edge of the cervical dura. Mark 2: Dark bluish-colored tumor which is reflected laterally away from the spinal cord which lies under the cut edge of dura mater.


Immunohistochemistry: (a) (HMB45 x10) Tumor cells showing diffuse strong positivity for HMB45.


(b) (S100 x10) Tumor cells showing diffuse positivity for S100.


(c) (Mib1 x10X)- Ki 67 was very low, around 1% in tumor cells.


Hematoxylin and eosin stained kidney tissue section reveals Neoplastic cells arranged in bundles and in streams (100x). The black arrow points at a dense area (Antoni A) and the blue arrow points at a looser area (Antoni B).


Hematoxylin and eosin stained kidney tissue section shows spindle and oval Neoplastic cells with cartilaginous islets at the middle (400x).


Pinkish papular lesions of viral warts on alopecic plaques.


Marked remission in warts after the 4th application of diphenylcyclopropenone.


Almost totally hair growth after the 17th application of diphenylcyclopropenone.


Ultrasound appearance of the tumor.


Computed-tomography appearance of the tumor.


Histologic examination. Core needle biopsy of the tumor:. Magnification x200, hematoxylin-eosin staining:small-blue-round-cell tumor.


Histologic examination. Magnification x200, PAS:positive staining.


Histologic examination. Magnification x200, S100:positive staining.


Histologic examination. Magnification x200; CD99:positive staining.


Postoperative specimen:left lobe of the thyroid with the isthmus.


Enlarged mass 6 month after the initial MRI scan. Preoperative sagittal.


Enlarged mass 6 month after the initial MRI scan. Axial. T1 enhanced Magnetic Resonance Imaging sans showing a round encapsulated left paravertebral mass at the L4-5 level.


Enlarged mass 6 month after the initial MRI scan. CT angiography. Demonstrating the location close to the aortic bifurcation (Arrow indicates tumor mass).


Diagram shows port placement for robot-assisted paraspinal tumor resection.


MRCP showing innumerable saccular dilations.


Associated with dilation of the main pancreatic duct and a 1.2 cm stone in the pancreatic head.


CT abdomen showing multiple cystic lesions within the pancreas. The largest cystic lesion in the mid-body pancreas measures 5.1 cm in maximal diameter and appears to communicate with the main pancreatic duct (A). Also seen is a cluster of smaller cystic lesions within the pancreas head and tail.


CT abdomen showing multiple cystic lesions within the pancreas. Downstream, again seen is a large 1.7 cm pancreatic duct calculus (B). The head and uncinate process of pancreas demonstrate multiple scattered punctate calcifications.


Gross view of the cut surface of the tumor with cystic and greyish-white solid area(arrowheads) that represent teratomatous component in microscopy.


X-ray skull was normal showing no bony lesion or lytic lesion. Inset (upper left) demonstrates the occipital swelling of the case.


Cytological smear showing cohesive clusters and scattered single meningothelial cells having indistinct cytoplasmic borders, round to oval nuclei and inconspicuous nucleoli. Inset (lower left) exhibits a psammomatous calcification. (Leishman-Giemsa, x400).


Section showing immunostaining positivity for epithelial membrane antigen in meningothelial cells (x100).


(a and b) The clinical appearance of the patient's right eye at presentation with ciliary injection, dark hypopyon and stromal haze (red arrow in 1b).


His B-scans showing no evidence of endophthalmitis on initial scan.


Then increasing vitreous opacities and RC layer thickening with suspected endophthalmitis on repeated examination.


Histological features showing non-caseating granuloma between the mucinous bronchial glands.


Submucosal granuloma consisting of a nodular cluster of epithelioid and giant cells.


Extensive intravascular filling defects of bilateral pulmonary arteries (red arrows).


The right ventricular (RV) cavity dilation with a thickened wall. The distorted interventricular septum (IVS) is pushed toward the left ventricular (LV) cavity.


The markedly congested lungs. A lobulated, pale, yellow mass is occupying the entire volume of the right and left main pulmonary arteries, loosely adherent to the pulmonary artery at multiple locations and measuring 13 cm in greatest dimension. The pulmonary artery mass extended into the parenchyma of the right upper lobe, 6 cm in greatest dimension.


The cells are positive for desmin and vimentin and showed focal reactivity for actin. This is consistent with a high-grade primary pulmonary artery leiomyosarcoma.


Slit-lamp photograph on the first postoperative day (A) showing white granular reaction with the presence of blood droplets, resembling diffuse lamellar keratitis into the flap tunnel.


On the fifth postoperative day, diffuse lamellar keratitis was completely resolved after corticosteroid treatment (B).


Physical and ultrasonography findings. A; Physical examination during the patient's visit revealed an elevated lesion with blue purpura around the nipple in the right breast.


Physical and ultrasonography findings. B; We performed breast ultrasound and detected a well-defined 19.6 x 16.4 x 10.7 mm hypoechoic tumor in the left subareolar area.


Physical and ultrasonography findings. C; Blood flow rich.


Macro- and microscopic diagnosis of the resected specimen. A; A dark-red tumor sized 18.0 x 12.0 mm was found in a specimen from the nipple.


Macro- and microscopic diagnosis of the resected specimen. B; The pathological diagnosis of the specimen revealed short spindle-shaped tumor cells with strong nuclear pleomorphism and a significant interstitial fibrosis (x200). Immunohistochemistry was performed, and the tumor cells were found to be vimentin positive and AE1/AE3, cytokeratin (CK) 7, CK20, gross cystic disease fluid protein, estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 negative; expression of Ki-67 was high.


Macro- and microscopic diagnosis of the resected specimen. C; Immunohistochemistry using D2-40 (x200) and CD31 antibodies showed irregular luminal proliferation at the anastomosis.


T1 weighted MRI with contrast.


Axial image of duplicate pituitary gland.


Coronal image of duplicate pituitary gland. Coronal image demonstrating two widely spaced pituitary stalks.


T1 weighted MRI with contrast of associated cranial abnormalities.


Axial image of midline third cerebral peduncle. Coronal image demonstrating fenestration of basilar artery, agenesis of corpus callosum.


Midline saggital T1 weighted MRI with contrast: defect in the clivus is observed with accompanying encephalocele. Naso-pharyngeal teratoma also observed.


Coronal T1 weighted MRI with contrast: odontoid process and vertebral body duplication.


(A) Peripheral sterile infiltrates and diffuse lamellar keratitis in the inferonasal area of the right cornea. Yellow arrows: Area of diffuse lamellar keratitis with "sands of Sahara" appearance. White arrow: Edge of the small incision lenticular extraction (SMILE) cap. Red arrows: Limbal inflammation. Black rectangle: Peripheral sterile (catarrhal) infiltrate of marginal keratitis. Slit lamp light has overexposed the area.


(B) Enlarged view of panel A. Yellow arrows showing diffuse lamellar keratitis. White arrow showing the edge of the SMILE cap. Red arrows showing limbal inflammation. Black arrows showing the catarrhal infiltrates.


38-year-old male presented with bilateral flank pain and was later diagnosed with bilateral renal lymphangiectasia. (a and b) Axial non-contrast CT images at the level of the kidneys show perirenal (long arrows) and peripelvic (short arrows) cysts with fluid density.


38-year-old male presented with bilateral flank pain and was later diagnosed with bilateral renal lymphangiectasia. (c and d) Sonography of the kidneys along the longitudinal plane show perirenal (long arrows) and peripelvic (short arrows) cysts with septations and clear fluid contents together with increased parenchymal echogenicity.


38-year-old male presented with bilateral flank pain and was later diagnosed with bilateral renal lymphangiectasia. MRI axial T1-weighted image of the kidneys.


38-year-old male presented with bilateral flank pain and was later diagnosed with bilateral renal lymphangiectasia. Axial post-contrast T1-weighted delayed phase image show the cysts have dark T1 signal (white asterisks) with lack of contrast pooling inside the cysts in the delayed phase, confirming absence of communication with the renal collecting system.


38-year-old male presented with bilateral flank pain and was later diagnosed with bilateral renal lymphangiectasia. Axial T2 fat-suppressed weighted image.


38-year-old male presented with bilateral flank pain and was later diagnosed with bilateral renal lymphangiectasia. Coronal reformatted maximum intensity projection T2 fat-suppressed image demonstrate cysts with fluid signal intensity (black asterisks) and dilated retroperitoneal lymphatic channels (arrowheads), together with dilatation and tortuosity of the cisterna chyli (long arrow) and thoracic duct (short arrow).


A exophytic lesion with measuring 8 cm by 4 cm at the right of the buccal mucosa. The surface of lesion is verrucous.


A verrucous carcinoma with parakeratin and the wide and elongated rete ridges that appear to push into the underlying connective tissue.


A verrucous area extended from the right buccal mucosa into the alveolar ridge, which tender to palpation. The tissue proximal to the lesion is erythematous and atrophic in appearance with indurations.


A early squamous cell carcinoma with some cell degeneration, keratin pearls, nests and cords of malignant epithelial cells with wide cytoplasm, round or oval nuclei, with prominent nucleoli and mitotic figures.


A crater like ulcer on the right lateral border of the tongue that extending into dorsal surface of the tongue.


An ulcero-proliferative lesion in the left mandibular ridge area.


A crater like ulcer on the left vermilion border of lip.


(a) Positive immunoreactivity of tumoral cells with anti-myoD1 antibody (x400).


(b) Positive immunoreactivity of tumoral cells with anti-myogenin antibody (x400).


(a) Nodular plaque over the left labia majora.


(b) Post-treatment with CO2 laser-day 1.


(c) Post-treatment - 2 months, healing with post-inflammatory hyperpigmentation.


(a) x10 view: Showing numerous horn cysts present throughout the dermis.


(b) x40 view: Showing cyst walls lined by eosinophilic epidermal cells, containing keratin.


(a) Front view: Initial photo.


(b) Front view: 12-year follow-up.


(a) Panoramic radiograph: A huge osteolytic lesion involving the right mandibular body and ascending ramus.


(b) 12-year follow-up radiography: Resolution of the lesion, with bone neoformation and dental implant osseointegration.


Computed tomography: Coronal view of an osteolytic lesion with bulging of the buccal and lingual cortex.


Transoperative photo: Surgical excision of the lesion using conservative technique.


Analysis of a CSF-470 VAC-SITE tissue. Dense clusters of CD11c+ cells were observed at the VAC-SITE, most of them also expressing PD-L1. Original magnifications = : 20X. Scale bars:. =200 mum.


Analysis of a CSF-470 VAC-SITE tissue. Dense clusters of CD11c+ cells were observed at the VAC-SITE, most of them also expressing PD-L1. : 100X. = 100 mum.


Analysis of a CSF-470 VAC-SITE tissue. Abundant CD68+ macrophages were also present in the area. Original magnifications = : 20X. Scale bars:. =200 mum.


Analysis of a CSF-470 VAC-SITE tissue. (E-G) CD8+ lymphocytes were mainly PD1- and many of them were proliferating (Ki67+). Original magnifications = : 20X. Scale bars:. =200 mum.


Analysis of a CSF-470 VAC-SITE tissue. (H,I) Numerous LMGC were observed by HE staining (arrows). : 100X. = 100 mum.


Analysis of a CSF-470 VAC-SITE tissue. (H,I) Numerous LMGC were observed by HE staining (arrows). : 1000X. = 20 mum.


Analysis of a CSF-470 VAC-SITE tissue. (J,K) The VAC-SITE was surrounded by numerous lymphatic and blood vessels (arrows). Original magnifications = : 20X. Scale bars:. =200 mum.


Analysis of C-MTS tissue. In the area of tumor regression (upper part of the biopsy), CD8.


Analysis of C-MTS tissue. And PD-1.


Analysis of C-MTS tissue. T lymphocytes were mainly present, while FOXP3+ Treg were scarce.


Analysis of C-MTS tissue. ; these lymphocytes were proliferating as determined by Ki-67+ staining.


Analysis of C-MTS tissue. Also, CD68+ macrophages.


Analysis of C-MTS tissue. CD11c Ag-presenting cells. Were mainly concentrated in this area.


Analysis of C-MTS tissue. In the lower part of the biopsy, MART-1.


Analysis of C-MTS tissue. PD-L1.


Analysis of C-MTS tissue. HLA class I +
 viable tumor cells were observed. Original magnification = 20X. Scale bars = 200 mum.


Radiological findings from an abdominal contrasted computed tomography scan. The damaged left kidney exhibits a poorly enhanced area and fluid and gas accumulation in the left retroperitoneal cavity (A,B).


Radiological findings from an abdominal contrasted computed tomography scan. A giant ureterocele evident in the bladder (C).


Ultrasound of the right axillary mass. . Notes: A low echo mass of 3.9x2.9 cm can be seen in the right axillary mammary gland. The boundary is still clear and the shape is irregular. A strong blood flow signal can be detected within it.


Image of core needle biopsy histologic diagnosis using hematoxylin and eosin staining (original x100). . Note: Metastasis of poorly differentiated carcinoma can be seen in the resected right axillary lymph node tissue.


Preoperative facial photo of patient. . Note: Before surgery, the dermal erythematous papules on the right side of the lower eyelid are prominent.


Expression of ER/PR by IHC staining (original x100) and HER2 by FISH analysis (original x400). . Notes: (A) ER-negative expression can be detected by IHC staining.


Expression of ER/PR by IHC staining (original x100) and HER2 by FISH analysis (original x400). (B) PR-negative expression can be detected by IHC staining.


Expression of ER/PR by IHC staining (original x100) and HER2 by FISH analysis (original x400). (C) HER2-negative expression result can be detected by FISH analysis. . Abbreviations: ER, estrogen receptor; PR, progesterone receptor; IHC, immunohistochemistry; HER2, human epidermal growth factor receptor 2; FISH, fluorescent in situ hybridization.


Postoperative facial photo of patient. . Note: Ten days after surgery, the dermal erythematous papules on the right side of the lower eyelid have nearly resolved.


Anteroposterior radiograph showing a SCS lead placement at T5-7.


Leptomeningeal enhancement involving brain and cervical spinal cord.


Ill defined granuloma with multinucleated giant cells (arrow) and bone fragments, HE staining, 4x.


Unenhanced CT showed the mass to be isoattenuating and barely perceptible.


Unenhanced CT showed the mass to be isoattenuating and barely perceptible. It demonstrated mild enhancement in the arterial phase.


Unenhanced CT showed the mass to be isoattenuating and barely perceptible. And moderate heterogeneous enhancement in the portal.


Unenhanced CT showed the mass to be isoattenuating and barely perceptible. And the late phases The corresponding CT values were measured (insert). There was no evidence of superior mesenteric artery or portal venous invasion.


There was no significant difference between the in-phase.


The out-of-phase MRI imaging.


The lesion was identified in T2-weighted images.


Diffusion-weighted images.


Coronal MRI imaging (E).


Magnetic resonance cholangiopancreatography.


Post-contrast MRI. T1WI without contrast enhancement.


Post-contrast MRI. , the arterial phase.


Post-contrast MRI. , the portal.


Post-contrast MRI.the late phases.


Erythema nodosum migrans. The lymphohistiocytic infiltrate mainly in the edematous thicken septum (H and E, x40(left), x100(right).


Axial CT head showing: almost total opacification of the right maxillary sinus with concentric soft tissues mass protruding into the nasal cavity deviating the nasal septum.


H & E staining: A- Low power magnification showing characteristic thick walled sporangia in various stages of development, containing endospores.


B- High power view with numerous endospores noted within the sporangia.


Orthopantomogram of the patient; asterix indicates the extent and nature of the radioluceny in between the apices of the right maxillary canine and lateral incisor. Inset shows the periapical radiograph of the area.


The lesional area after raising the semilunar flap. Note the shape of the lesion and bone overlying the cyst.


Total removal of the cystic content in toto.


Timeline.


(A) One of the two smaller trichilemmal cysts (TCs).


(B) Proliferating trichilemmal cyst (PTC) peroperative.


(C) PTC with an ulcerating center.


(D) Defect after removal of PTC.


(E) Closure with local fasciomusculocutaneous flaps.


(F) Small wound 6 months after primary closure.


(A) One of the two smaller TCs.


(B) PTC axial view.


(C) PTC coronal view.


(D,E) Macroscopy of the PTC.


(F) Macroscopic view of sliced PTC.


(G) Microscopy of PTC, depicting surface epithelia and a tumor process.


(H) Microscopy depicting the compact keratin and calcifications.


(I) Microscopy with squamous epithelial cells without a granular cell layer.


Contrast-enhanced axial computed tomography scan showing hypodense, enhancing lesion in the left L5-S1 neural foramen.


MRI showing a round lesion in the L5-S1 neural foramen arising from the left S1 nerve root, hypointense on T1, and hyperintense on T2, with a peripheral ring enhancement after gadolinium injection suggesting a schwannoma.


Pathological examination showing the tumor consists of spindle cell proliferation with compact hypercellular areas and myxoid hypocellular areas. Cells are narrow, elongate, and wavy with tapered ends interspersed with collagen fibers without evidence of mitosis. Nuclear palisading around fibrillary process is often seen in cellular areas; large irregularly spaced vessels are most prominent and gaping tortuous lumina have thickened hyalinized walls.


One-month postoperative MRI shows a left L5 laminectomy, left-sided foraminotomy, with total resection of the schwannoma.


PCD at time of presentation.


Venogram Pre PCDT.


Venogram during PCDT.


May-Turner syndrome during venogram (in prone position).


Venogram post PCDT & stenting.


INI staining. Immunohistochemical stain for INI1 showing abnormal loss of nuclear staining of the rhabdoid cells with normal nuclear staining of the capillary endothelial cells and infiltrating lymphocytes. Very faint staining of the cytoplasmic inclusion is noted.


Electron microscopy. EM picture of a rhabdoid cell showing the vesicular nucleus with a large nucleolus and a pale whorled aggregate of intermediate filament displacing the formed cytoplasmic organelles.


Intense desmin staining of the tumor cells (IPOX, 200).


(a) Right eye at presentation showing peripapillary hemorrhage (1 and 2), blurring of disc margins (3) and exudate (4).


(b) Left eye at presentation showing flame shaped hemorrhage (1), blurring of disc margins (2), peripapillary hemorrhage (3) and macular edema (4).


T2-weighted magnetic resonance imaging of the brain showing (1) bilaterally hyperintense mamillary bodies (2) bilaterally hyperintense thalami.


Right eye, 2 weeks later showing complete resolution of disc edema.


Early and late 99mTc MIBI Parathyroid Scan images of neck and mediastinum anteriorly at 20 min and 2 h.


A. Photomicrograph depicting papillary structures with hyalinized stalks lined by epithelial cells exhibiting hobnailing into cystic spaces. A psammomatous calcification is also present (hematoxylin and eosin stain, x100).


B. High-power view shows the hobnail growth pattern of the epithelial cells which have the nuclear features of papillary thyroid carcinoma in the form of nuclear enlargement, overlapping of the nuclei, irregular nuclear membranes with occasional nuclear grooves. The cells have abundant eosinophilic cytoplasm with oncocyte-like appearance (hematoxylin and eosin stain, x400).


Histological section shows a well-circumscribed parathyroid adenoma with a thin capsule surrounded by thyroid tissue (hematoxylin and eosin stain, x40).


A. TTF1 immunohistochemical stain demonstrates negative staining in the parathyroid adenoma (left) and positive nuclear staining in the adjacent thyroid tissue (right).


B. Thyroglobulin immunostain is also negative in the parathyroid adenoma and demonstrates positive staining in the adjacent thyroid tissue.


Standard X-rays after the injury.


Diffuse hair loss on the frontal scalp and vertex of the scalp with decreased thickness of temporal and occipital hair.


Subepithelial fibrosis of the right superior palpebral conjunctiva.


Foreshortening and symblepharon of the right lower palpebral conjunctiva.


Facial asymmetry with bony prominence on left side.


Computed tomography scan showing well-delineated soft tissue mass in infratemporal and buccal space.


Gross specimen showing cystic cavity.


Cystic cavity lined by stratified squamous epithelium and foci of pseudostratified squamous epithelium (H and E, x10).


Contrast enhanced computed tomography of abdomen and pelvis (axial section) shows A. Enhancing Intraluminal caecal mass with caecal wall thickening. Adjacent necrotic mesentric nodes and . Dilated small bowel loops with few of them having thickened walls.


Contrast enhanced computed tomography of abdomen and pelvis (axial section) reveals thickened ileum loop extending into the cecum (arrow).


Hematoxylin and eosin stained sample. At x10.


At x40 demonstrate large monomorphic tumor cells having large round cell nucleus and abundant eosinophilic cytoplasm (seen arranged in cords and nests in Figure 3a).


Hematoxylin and eosin stained tissue. At x10.


At x40 show glandular formation (arrow) amounting to >30% of the tumor.


General view of the vulvar schwannoma before surgical resection: a round subcutaneous nontender solitary tumor with a blue-gray color and a black dot on the left labium majus.


Immunohistochemical examination showed that the spindle cells were diffusely positive for S-100 protein.


Aquagenic keratoderma of the palms after water immersion in a 12 year-old girl.


Aquagenic keratoderma of the palms in a 27 year-old male with palmar hyperhidrosis and cystic fibrosis. In the presentation without water immersion a milder clinical appearance of whitish translucent papules is obvious.


Elongated styloid process (SP) on both sides with suspected fracture of left SP.


Undisplaced fracture of left styloid process.


The mass is seen at the incision site (white arrow).


Positron-emission tomography imaging demonstrates increased FDG uptake of the mass. White arrow).


Thickened pericardium. White arrow).


Axial and coronal contrast-enhancing T1WI showing a left CP angle enhancing mass with intrameatal extension and cystic changes measuring mass 23 x 25 x 18 mm on presentation in September 2007.


Axial and coronal contrast-enhancing T1WI in May 2008 with tumor measuring 13 x 17.5 x 10.4 mm.


Axial and coronal contrast-enhancing T1WI in May 2009 with tumor measuring 15 x 18.7 x 11.5 mm.


Axial and coronal contrast-enhancing T1WI in September 2009 with tumor measuring 24.5 x 25 x 17.5 mm.


Axial and coronal contrast-enhancing T1WI in February 2010 with tumor measuring 15 x 18 x 12 mm.


Graphical representation of tumor volume over time.


GKS plan March 2010.


Axial and coronal contrast-enhancing T1WI in May 2011 with tumor measuring 15 x 11 x 9 mm.


Hyperpigmented and hypopigmented macules over dorsum of hands.


Hyperpigmented macules over both palms.


Freckle like macules over face.


Mottled pigmentation over buttocks.


Phylogenetic tree analysis of a large subunit (LSU) rRNA gene of isolated Candida sp. , LYS-1.


Endoscopic retrograde cholangiopancreatography demonstrating constriction of the main duct bifurcation and the prepapillary region (marked with arrows).


Magnification of 200-400x, section 1 stained with HE, section 2 after immunohistochemistry against CK7 showing destruction of the bile ducts and the formation of epithelioid cells around the bile ducts.


Ultrasound image of the three muscle layers. . Notes: TM, RMM, and ESM overlying the T2 TP. LA spread is seen in between the ESM and T2 TP. . Abbreviations: ESM, erector spinae muscle; LA, local anesthetic; RMM, rhomboid major muscle; TM, trapezius muscle; TP, transverse process.


Extent of diminished sensation to pin prick on postoperative day 1; right shoulder and right scapula.


Extent of diminished sensation to pinprick on postoperative day 1; right axilla and right anterolateral chest wall.


The axial image on computed tomography (CT) (a) showed that the transverse foramen magnum diameter was smaller than the anteroposterior diameter.


The sagittal image on CT (b) showed the sagittal area on the midline posterior fossa.


(A,B) Cesarean delivery wound before treatment for pyoderma gangrenosum on 1st day of admission.


(C) Appearance of wound on 13th day of hospitalization.


(D) Appearance of wound after complete healing.


Clinical features and genetic sequencing data of the patient. (A) The pedigree of the family.


Clinical features and genetic sequencing data of the patient. (C) Contrast-enhanced CT scan of abdomen shows a significantly enlarged liver with fatty change.


Clinical features and genetic sequencing data of the patient. (D) Sanger sequencing shows that the patient harbored homozygous mutations (c.454C>T, p. Q152*) in exon 6. The patient's parents and brother were all heterozygous for this mutation.


Fundus photos of both eyes showing optic nerves with a normal appearance, and pigment mottling in the macula in the right.


The left eye.


Goldmann visual fields documented bilateral central scotoma to the I4e test isopter, spanning a 10-degree radius from the center of vision both in the left.


The right eye.


Preoperative MRI dated 1 month before surgery. (a) Axial T1WI MRI showing extensive amorphic heterogeneous mass invading both lateral ventricles with a commitment of midline.


Preoperative MRI dated 1 month before surgery. (b) Axial T1WI Gd MRI demonstrates the same lesion with ring and internal enhancement.


Preoperative MRI dated 1 month before surgery. (c) Coronal T1WI Gd MRI showing better the internal enhancement and commitment of both lateral ventricles.


Preoperative MRI dated 1 month before surgery. (d) Axial T2WI MRI exhibiting heterogeneous intratumoral signal and irregular-margin enhancement. Note hypointense signal surrounding the lesion suggesting extensive vasogenic edema.


Preoperative MRI dated 1 month before surgery. (e) Axial DWI shows nonimpaired diffusion.


Preoperative MRI dated 1 month before surgery. (f) ADC Map demonstrating high signal.


Immediate postoperative Control MRI. (a-c) T1WI Gd MRI exhibiting residual mass on the left ventricle atrium.


Immediate postoperative Control MRI. (d-f) T2WI MRI demonstrating residual mass on the left ventricle atrium. The inclusion criteria in our first systematic review were case series studies with at least ten patients containing GS with molecular profile study (IDH1/2, ATRX, tp53, TERT, 1p19q, or Ki-67). Cases series without any molecular profile were excluded from the study.


Postoperative MRI one month after surgery. (a-c) Axial T1WI Gd MRI showing notorious residual lesion growth.


Preoperative (2008) axial.


Coronal.


Sagittal. Postcontrast T1-weighted magnetic resonance imaging scans show a 3 cm extra-axial, heterogeneously enhancing mass in the right parieto-occipital region.


Postoperative computed tomography head (3D) scans showing the extent of calvarial resection.


Recurrent inguinal low grade fibromyxoid sarcoma involving scrotum in a 38-year-old patient.


Magnetic resonance imaging. . A) Cross section revealing inseparable inguinal mass with structures of the scrotum.


Magnetic resonance imaging. B) Sagittal section showing the relationship between the tumor mass and the adductor musculature of the left thigh.


Aspect after resection of inguinal low grade fibromyxoid sarcoma involving the scrotum.


Aspect after reconstruction.


Histological image of the low grade fibromyxoid sarcoma showing an admixture of collagenized and hypocellular myxoid zones with arcades of small vessels.


CT findings of primary tumors.


Histological features of primary tumors. Histological examination revealed the tumor to be a mixed germ cell tumor which included a grade 3 immature teratoma, mature teratoma, embryonal carcinoma, and yolk sac tumor.


CT findings of three sites of tumor recurrence. The recurrent tumors are indicated by white arrows. A; The appearance of a recurrent tumor of pelvic dissemination.


CT findings of three sites of tumor recurrence. The recurrent tumors are indicated by white arrows. B; The appearance of a recurrent tumor of the para-aortic lymph node.


CT findings of three sites of tumor recurrence. The recurrent tumors are indicated by white arrows. C; The appearance of a recurrent tumor of the lung.


Primary melanoma of the cornea.


Medical image.


Corneal pigmented lesion, clearly demarcated, and ,surrounded by clear cornea, with two feeder vessels derived from the limbus.


Inability of complete eyelid closure.


Imaging which did not reveal associated pathology.


Scan.


UBM - lesion sparing posterior stroma and endothelium; (courtesy of Dr. Miltos Balidis, OPTHALMICA Eye Institute).


Photographs taken post-operatively.


Day 1.


Week 6.


Week 8.


Histologic features;. Low-power view of the neoplasm, hematoxylin-eosin, x100.


High-power view illustrating the cytologic features of the tumor cells, hematoxylin-eosin, x400.


Positive immunostaining of the tumor cells for Melan-A antigen, automated immunohistochemistry, x400; (courtesy of Prof. Prodromos Chitiroglou, Pathology Department, Aristotle University of Thessaloniki, Greece).


A. Distended abdomen before surgery.


B. Computed tomography revealed the large cyst and solid component showing enhancement.


C, D. T2-weighted magnetic resonance imaging also showed the large cyst and solid component with high signal intensity.


T2-weighted sagittal image showing hyperintense changes from cervico-medullary junction to C7-T1 level, surrounding the relatively isointense tumor at the C3/C4 level.


Postgadolinium sagittal.


Axial. Images showing an intensely enhancing intramedullary mass at C3-C4 level.


Histopathological examination showing a spindle cell tumor with Verocay bodies, consistent with schwannoma.


(a and b) One-year follow-up imaging. T2-weighted sagittal image.


(a and b) One-year follow-up imaging. Postgadolinium sagittal image. Showing thinning of the cord at the operated level and no residual lesion.


The regular CT scan before and after sunitinib treatment. Radiology of pretreatment . . Notes: (A) Baseline with evidence of lung (right red arrow) and pancreas (left red arrow) metastases before starting sunitinib.


The regular CT scan before and after sunitinib treatment. Post-treatment. Findings in our patient under sunitinib treatment. (B) Evidence of decrease in tumor size on regular scan after 3 months of sunitinib treatment.


Plain radiography. A; A ground-glass appearance with marked calcification and a pathological minor fracture in the right proximal femur.


Plain radiography. B; Multiple ground-glass appearances in the skull.


MRI. A; Isointensity with punctate low signal intensity on T1-weighted images.


B; Irregular high signal intensity on T2-weighted images.


C; Irregular peripheral predominant enhancement on Gd contrast-enhanced images.


Bone scintigraphy showing an accumulation of radioactivity in the right ilium, right proximal femur, right proximal ulna, and the skull.


A; Pathological fracture with displacement in the metaphysis of the right femur.


B; Artificial bone was implanted after curettage and fixed with a locking plate so that the varus of the proximal femur was corrected.


Histopathological findings of the specimen. A; Nodular hyaline cartilage tissue is present in the majority of the specimen without marked atypia.


Histopathological findings of the specimen. B; Proliferation of fibroblast-like spindle cells and woven bone were evident in parts of the lesion.


Evidence of post-axial polydactyly surgery. (A) Right foot, surgical scar where additional digit was removed.


Evidence of post-axial polydactyly surgery. (B) Left foot, surgical scar where additional digit was removed.


Thrombus in left atrium and left ventricle.


Thrombus in right atrium, left atrium, and left ventricle.


Non-contrast CT scan of the abdomen showing extensive extraperitoneal perinephric gas extending to paranephric space accompanied by renal parenchymal destruction.


During the operation, a tumor was seen originating from the sciatic nerve sheath.


A; Histopathological examination (H&E, x40) showing a rich cell neoplasm, with bland round-to-spindle-shaped and wavy nuclei, loosely arranged in sheets; the margin of the tumor is lined by a well-defined fibrous capsule (black arrow).


B; Area of microcyst formation, suggesting schwannoma (H&E, x400).


Larva of Eristalis tenax isolated from the nose of the patient (original photo).


Identification of the genetic basis of polyhydramnios in a Chinese family. (A) Family pedigree and DNA sequencing results. Filled triangle with oblique line indicates the fetus with polyhydramnios terminated by therapeutic abortion. Filled square with oblique line indicates the affected boy who died after birth. Arrow indicates the proband. Open symbols indicate clinically unaffected family members. LMOD3 genotypes are provided for all subjects. Red arrows indicate the mutation positions. Wt, wild-type.


White fluffy keratic precipitates on the endothelial surface of the patients cornea 19 days after the initial DMEK surgery.


Intraoral view shows buccal and palatal expansion in the left maxillary region and the exophytic ulcerated mass.


Computed tomography scan shows extensive destruction of the left maxillary sinus.


Photomicrographs showing (a) benign-appearing epithelial islands and highly cellular mesenchymal component. Original magnification x100), (b) pleomorphism, and . Scattered bizarre cells in mesenchymal component. Original magnification x100).


Anteroposterior abdominal radiography demonstrating radiopaque, elongated
structures in the region of the bowel loops (arrow) and gaseous distention of
small bowel loop in the center of the abdomen.


Axial abdominal CT section demonstrating thickening and calcification of
intestinal and peritoneal walls (arrow).


Coronal abdominal CT section presenting gross calcifications in intestinal and
peritoneal walls (arrow) and distended bowel loops with fluid and air contents
located in the central region of the abdomen (arrowhead).


Sagittal abdominal CT section showing thickening and calcification of intestinal
and peritoneal walls (arrow). Presence of linear, gross calcifications.


A: Ultrasonography scan of the upper abdomen shows a round and well-defined mass in the stomach. Fig. 1B: Endoscopic ultrasound reveals a 2.5 x 1.5 cm hypoechoic mass that appears to arise from the muscolaris propria of the lesser curvature.


Spindle cells arranges in fascicles (HE 4x) and in the frame the mass partially surrounded by lymphoid aggregates (HE 10x).


Tumor cells are positive for S-100 protein in both cases (IHC case 1, 4x Fig. 3A), (IHC case 2, 4x Fig. 3C) and negative for CD-117 protein (ICH case 1, 40x Fig. 3B) and CD-34 (IHC case 2, 10x Fig. 3D).


Contrast enhanced CT showing a round, well-defined and homogeneous gastric mass (Fig. 4A) and endoscopic detection (Fig. 4B) in submucosal of the greater curvature of the stomach. In the frame, macroscopic view of the resected mass shows a large exophytic mass along the less curvature of the stomach.


T2 weighted fat saturated.


T2 weighted. Magnetic resonance imaging of the whole spine - sagittal view.


Sagittal views of the cervicodorsal spine in T1.


T2 fat saturated.


T2 weighted. Magnetic resonance images.


Axial cuts of T2 weighted magnetic resonance imaging showing heterogeneously intense intramedullary lesions within the cord at C3.


Medical image.


C7. Vertebral levels.


Sagittal views of the lumbosacral spine in T2 fat saturated magnetic resonance images without.


With. Contrast.


(a) Intraoperative photograph showing the intradural exposure of the conal lesion.


(b) Visualization of the tumor under the operative microscope with well-formed hairs (yellow arrowheads) within the lesion.


Fiberoptic findings in primary situation.


A modest improvement in edema and symptoms during prednisolone 60 mg/days treatment.


Significant improvement in edema and symptoms 2 weeks after rituximab (c).


Seven months after rituximab treatment, the patient was free of symptoms (d).


Histological findings.


Showing granulomatous reaction in lingual tonsil with CD68 (Kp-1) positive epitheloid histiocytes by immunohistochemistry.


Strong CD20-immunopositivity in B-lymphocytes (d).


Most CD3-positive.


T-lymphocytes showed also CD4-positivity.


Positron emission tomography:computed tomography showed increased activity (arrows) in the lingual tonsil.


Without evidence of widespread sarcoidosis.


A tuft of terminal hairs in the LS region (Faun tail).


Chest X-ray from posteroanterior projections.


Left lateral. Showing discrete perihilar opacities poorly defined at right.


Axial sections of computed tomography before.


After. The infusion of iodinated contrast agent, revealing nodular hypodense lesion with ring- enhancement, in the left cerebellar hemisphere.


Reformation in the coronal.


Sagittal. Confirmed the lesion was located in the posterior cranial fossa.


Brain MRI. (a) T1W nodular lesion with peripheral hyperintense rim surrounding a hypointense white matter in the left cerebellar hemisphere.


Brain MRI. Axial images in. T2W sequences.


Brain MRI. FLAIR-perilesional edema, heterogeneity with peripheral hypointense white matter, center hyperintense.


Brain MRI. (d) T1W revealed ring-enhancement after intravenous infusion of paramagnetic contrast (gadolinium) in axial section.


Brain MRI. Axial image of diffusion- DWI sequences. Lesion hyperintense center.


Brain MRI. Apparent diffusion coefficient , hypointense lesion with restricted diffusion of water molecules.


Proton spectroscopy curvs for magnetic resonance of cerebellar lesions showing increased peaks of lactate and lipids and reduction of N-acetyl-aspartate (NAA) peak, without increasing of choline peak.


Clinical image of the breasts revealing a large left breast mass.


(A) Mammogram (medial-lateral oblique view) of the left breast demonstrating a large central breast mass.


(B) Ultrasound with color doppler of the solid, vascular portion of the left breast mass.


(C) MR image of the left breast mass demonstrates the large cystic portion and one of the enhancing solid portions of the complex mass.


H&E 40 x 5 - high magnification view of core biopsy sample demonstrates apocrine atypia.


H&E 10 x 3 - low magnification view of mastectomy sample demonstrates papilloma.


Extra-ocular movement just before the 8th TMS in the 1st course. The patient exhibited vertical misalignment for the upper and upper lateral gaze, especially the upper-right gaze.


During substrate mapping in sinus rhythm, delayed and late potentials (black arrow) were identified at the mapping catheter.


Pacemapping at the area of late potential showed good matching with induced VT.


Pacemapping at the area of late potential showed good matching with induced VT. 12 lead ECG during pacemapping. 12 lead ECG duing ventricular tachycardia.


A growth on the right lateral border of the tongue.


Periodic acid-Schiff positive mucinous material present in ductal lumens (PAS, 40x).


MRI of left Ankle.


(a and b) Biopsy report and histology slide.


At 3-month follow-up.


Axial PET/ CT images of abdomen demonstratinghypodense abscess cavity in the postero inferior part ofright kidney with multiple pockets of air lucencies within (arrow) and FDG avid uptake in the peripheral enhancingpart(dotted arrow).


Coronal PET/CT sections showing extension and infiltration inferomedially into adjacent right psoas muscle (arrow).


Axial contrast CT section ofurinary bladder showing a hypodense filling defect at the right vesico ureteric junction(solid arrow) and freegas lucencies in the anterior aspectof urinary bladder(dotted arrow).


Ultrasound abdomen outlining enlarged right kidney with ill defined heterogeneous mass in postero inferior portion (arrow) containing dirty echogenic foci of air (dotted arrow).


Pre treatment staging coronal PET/CT images showing normal morphology of both kidneys.


Follow up ultrasonography showing complete disappearance of the abscess and return of the renal contour to normal.


Swelling on the thenar aspect of the right palm.


Magnetic resonance imaging (T2-weighted) showing a well-defined, sharply demarcated, heterogeneously hyperintense lesion.


(a) Intraoperative view of the lesion while dissection.


(b) Specimen after complete excision.


Image of the right hand after 3 weeks of surgical excision of the space-occupying lesion.


Preoperative clinical photograph.


Postexcision photograph.


Left: gross picture of the sebaceous carcinoma of the back. Right: histology confirming sebaceous carcinoma with free margins.


Histology demonstrating microsatellite instability in MSH2 and MSH6.


Papillary luminal proliferation with intraepithelial crypts filled with mucin.


Epithelial plaque showing clear cells and epidermoid-like cells.


Epithelial sphere or epithelial plaque showing mucous cells.


Cystic spaces in capsule filled with mucin.


Mucicarmine stain: Mucous cells and mucous pooling showing positivity.


Alcian blue stain (acetate buffer, pH 2.5) showing positivity for mucous cells and mucous pooling.


PAS stain: Clear cells showing positivity (without diastase).


PAS stain: Clear cells becoming empty again after using diastase (indicating the presence of glycogen).


In 2011, orthopantomogram was taken which showed one well-defined radiolucency.


In 2014, orthopantomogram was taken, which showed two well-defined radiolucencies.


Fused ribs.


Calcification of falx cerebri.


Bridging of sella turcica.


Dermoscopic features of zone A shows an exclamation mark hair (1), and ,broken hair (2).


Dermoscopic features of zone B without signs of activity of the alopecia areata.


Dermoscopic features of zone C shows an exclamation mark hair (1) and broken hair (2).


Whole-body 18-fluoride-fluoro deoxyglucose (18F-FDG) positron emission tomography-computerized tomography (PET-contrast enhanced CT) scan. Maximum intensity projection.


Axial CT.


Fused PET-CT.


Coronal CT.


Coronal fused PET-CT) performed as per standard protocol showed an intensely FDG avid soft tissue mass in the right thoracic cavity with chest wall infiltration. Intensely FDG avid paracardiac soft tissue masses were also noted. There was a focal FDG uptake in the lateral end of left clavicle which was equivocal for metastases.


FNAC smears showed monotonous cells in small clusters and singlefile pattern with a prominent myxoid stroma (Pap, x100).


Telangiectasias were noted on the back and trunk.


A contrast enhanced CT scan of the abdomen demonstrates showing a large right-sided perinephric fluid collection.


CT scan of the pelvis showing heterogeneously enhancing mass replacing the prostate infiltrating the bladder base and Foley's bulb and catheter in situ.


Hematoxylin and eosin (H & E) stained image showing sheets of cells having hyperchromatic nuclei at 10x magnification.


H & E stained image showing sheets of cells having moderate amount of eosinophilic cytoplasm and hyperchromatic nuclei at 40x magnification.


Immunohistochemistry 40x image showing desmin positivity.


Immunohistochemistry 40x image showing myogenin positivity.


Lesion on the right thumb shown in December of 2016 prior to surgical treatment.


Initial patient presentation to the plastic surgery clinic in August of 2017 post initial surgery demonstrating the recurrence of the lesion on the dorsum of the right thumb interphalageal joint.


(a,b) Images taken two weeks apart showing aggressive re-occurrence of the lesion after the second surgery in April of 2018.


(a,b) Images taken after the third surgery in 2018 showing final functional ability.


Optical coherence tomography of the right eye before surgery showing a full thickness macular hole with intraretinal cysts.


Macular hole closure 6 months after surgery Note the restructuring of the photoreceptor layer of the retina. In foveal center, there was partial restoration of the external limiting membrane (ELM) and ellipsoid zone layers.


Color fundus picture and optical coherence tomography (OCT) of the right eye before surgery, showing a large macular hole (a-b).


Five months after surgery, the macular hole was closed (c). In foveal center, no restoration of the external limiting membrane (ELM) and ellipsoid zone layers was verified.


Color fundus picture and optical coherence tomography (OCT) before surgery, showing large macular hole (a, b).


Six months after surgery, MH with dimensions similar to baseline values (c).


A - Myxoma (Hematoxylin-Eosin x100): neoformation consisting of mucous pools and eosinophilic loose connective tissue stroma with low celularity, mainly fibroblasts and inflammatory cells.


A 1.5 cm diameter nodule on left half of upper lip before excison.


FNAC: aggregates, acini and single scattered benign epithelial cells along with myoepithelial cells and chondromyxoid stromal fragments (Giemsa stain, x40). . Abbreviations: FNAC, fine needle aspiration cytology.


(A) FNAC smear showing sheet of myoepithelial cells with basophilic dense cytoplasm and central to eccentric, round to oval nuclei with bland chromatin (Giemsa stain, x200).


(B) Cluster of epithelial cells with scattered myoepithelial cells in a chondromyxoid background (Giemsa stain, x200). . Abbreviations: FNAC, fine needle aspiration cytology.


H&E. x40. Cellular proliferation with weak nuclear pleomorphism.


H&E. x20. Osseous infiltration by the neoplasm.


Prolactin serum behavior 04/1994 to 12/2006.


Anterior segment photographs before and after medication. A; Marked conjunctival hyperemia and corneal edema together with a small abscess in the inferior cornea and hypopyon are shown.


Anterior segment photographs before and after medication. B; The cornea is clear and the infection did not recur.


Cross-sectional image of the infected cornea on optical coherence tomography. The abscess is located only in the recipient cornea. White arrows indicate host-graft interface. Black arrows indicate the abscess.


Erosive lichen planus in the retro molar right buccal mucosa.


Histopathological findings at erosive lichen planus.


Deposits of immunoglobulin G by the length of the epithelial basement membrane and superficial layer of the lamina propria at oral lichen planus.


Deposits of immunoglobulin C3 by the length of the epithelial basement membrane and superficial layer of the lamina propria at oral lichen planus.


Application of the NBF gingival gel at the site of the buccal mucosae lesion.


Healed mucosal lesion after third week of therapy with NLB gingival gel.


(A) Multiple translucent skin-colored, bluish cystic lesions in periorbital distribution, cheeks, and zygomatic region.


(B) Unilocular cyst lined by two layers of flattened cuboidal epithelium without any evidence of decapitation in lining cells (hematoxylin and eosin, x40 magnification).


(C) Whitish clod (yellow arrow) without crater seen on dermoscopy (nonpolarized mode, x170 magnification).


(D) Yellowish globules (blue arrow) with multiple telangiectasias (white arrow) seen on dermoscopy (polarized mode, x170 magnification).


Immunohistochemistry staining showing CD4 positivity.


Family pedigree of the patient which demonstrates autosomal dominant inheritance.


A mixture of hypopigmented and hyperpigmented macules on the patient's trunk and extremities.


Diffuse lamp examination photograph taken at the first visit. Small whitish infiltrates are observed in the superficial corneal stroma at the 8 o'clock area.


At 9 days after the patient's first visit, characteristic interface infiltration was observed (arrow) between the graft and host cornea, which is enlarged around the ulcer and within the DSAEK area. . Abbreviation: DSAEK, Descemet stripping automated endothelial keratoplasty.


Smear of the corneal scraping that shows budding yeasts.


Blood coagulation was observed within the interface between the graft and host cornea (arrows) on the day after an intrastromal injection of the antimycotic agent.


Histological analysis of the excised cornea. Descemet's membrane was detached due to the pathological process (arrow). Inflammatory cells and fibrin are observed filling the perforated area (*) and spreading into the surrounding tissue (**). Grocott staining (inset) indicates the presence of a few fungal organisms.


A 16 year old girl with bilateral papillary thyroid carcinoma. (A) Axial enhanced CT neck showing enhancing mass lesion involving right thyroid lobe. The left lobe appears to be normal in CT scan.


Selective right external carotid angiogram showing highly vascular fistulous type of lesion fed by superior thyroidal artery and draining into internal jugular vein corresponding to vascular lesion visible on CT neck giving rise the suspicion of thyroid paraganglioma.


Post right thyroidectomy and isthmectomy CT neck coronal enhanced view showing metastatic nodes on right side at level IV and level VI compressing the internal jugular vein.


Chest x-ray. Right diaphragmatic paresis and poorly inflated right lower lobe.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (A) The section shows muscle tissue (big arrow) of the diaphragm and granuloma (star) surrounded by adipose tissue (white arrow) close to the serosa (small arrow) of the pleura, at magnification 200x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (B) Granuloma (star) at magnification 400x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (C) Non-caseating granuloma consisting of Langerhans giant cells (big arrow) and epithelioid cells (small arrow), magnification 800x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (D) Myositis with lymphocytic infiltrate (star) of the muscle tissue, already showing destruction of the muscle cells, magnification 800x.


Sagittal fat suppressed T1-weighted.


T2-weighted. Magnetic resonance images of the lumbosacral spine. A heterogeneous, predominantly cystic, intramedullary space-occupying lesion measuring 2.5 x 1.2 cm is present within the filum terminale at L2/3 level (green arrow). Additional findings include a transitional lumbosacral vertebra (lumbarisation of S1), dehydration of the L5/S1 intervertebral disc with a posterior disc bulge, and a hemangioma in the vertebral body of L5. The remainder of the spinal cord and conus medullaris, lower thoracic and lumbosacral vertebrae, intervertebral disc spaces, and paraspinal soft tissues appear normal.


Diffuse infiltration of ear-lobe.


Multiple erythematous papules and nodules (ENL lesions) over face.


Forehead.


Multiple erythematous papules and nodules (ENL lesions) over lower limbs.


Low power view x10. Mild hyperkeratosis in epidermis, grenz zone. Dermis shows edema with collection of macrophages.


High power view x40. -Vessels show acute and chronic perivascular inflammatory infiltrate.


Patient 1. Computed tomography scan showing left cerebellopontine angle lesion hemorrhage (a).


Patient 1. T1-weighted magnetic resonance imaging revealed a widened internal acoustic meatus and intratumoral hyperintense signal changes (white arrowheads) suggestive of hemorrhagic vestibular schwannomas compressing the brainstem. Axial.


Patient 1. . Coronal).


Patient 1. The corresponding areas are isointense (gray arrowhead) on T2W imaging indicating subacute (6-9 days) methemaglobin blood (d).


Patient 1. Contrast-enhanced T1-weighted scan demonstrated heterogeneous enhancement with widening of the internal acoustic meatus indicative of a multicystic vestibular schwannoma(e).


Patient 1. Susceptibility-weighted imaging revealed diffuse hypointense signal changes reflecting blood product deposition (f).


Patient 2. Computed tomography scan revealing acute intratumoral hemorrhage at right cerebellopontine angle causing brainstem compression The widened IAM is suggestive of vestibular schwannomas (a, white arrow).


Patient 2. And acute obstructive hydrocephalus.


Patient 2. One-month postoperative contrast-enhanced T1-weighted magnetic resonance imaging showing residual tumor extending into the IAM (c). Patient 3.


Patient 2. Computed tomography scan showing a left cerebellopontine angle hemorrhagic tumor (d).


Patient 2. Contrast-enhanced T1-weighted magnetic resonance imaging revealing a widened IAM and heterogenous enhancement (e).


Patient 2. SWI depicting intratumoral blood product deposition (f).


Sagittal.


Axial. Gadolinium enhanced images.


(c) T2-weighted axial image.


(d) Coronal gadolinium enhanced image. High magnification image from. Revealing enhancement within the right optic chiasm (Rt OC).


(e) T2-weighted axial image showing involvement of the optic chiasm. High magnification image from. Revealing hyperintense signal in the optic chiasm (OC).


Medical image.


Intraoperative image revealing the extent of optic chiasm enlargement from a right lateral suprachiasmatic view. OC - optic chiasm, Lt ON - left optic nerve, Rt ON - right optic nerve, Rt Al - A1 portion of the right anterior cerebral artery.


Contrast-enhanced computerized tomography of the thorax (axial,. Mediastinal window.


Pulmonary window.


Coronal sections) delineating a well-defined pulmonary mass in the superior segment of right lower lobe.


Contrast-enhanced computerized tomography of the thorax (axial sections:. Mediastinal window.


Pulmonary window) at 6-year follow-up.


Reticular, erythematous lesions involving the maxillary and mandibular gingiva.


Post operative photograph of healed hard palate excisional biopsy.


Computed tomography.


Prominent decrease in pleural fluid was observed at sixth month of treatment.


Well-circumscribed, gray-white, solid masses with a smooth outline measuring 2cm x 1.5cm x 1.5cm.


Case 1: Maculopapular rashes over trunk, face and forearm.


Case 2: Maculopapular rashes over trunk.


Case 3: Maculopapular rashes over forearm.


Infantile Fibrosarcoma with High mitotic figures.


Composite images of chest radiography of patient 2 showing miliary nodules (left) and HRCT images (major fissure level) showing upper lobe-predominant random nodules. No involvement of the fissure or "beading" of the fissure is seen.


Composite image of Photomicrographs of lung biopsy sample of Patient 2 with left, [Hematoxylin and Eosin stain (H & E), x scanner power] showing multiple non-necrotizing perivascular granulomas, and right, [H & E stain, x 40) showing a Schaumann body within a giant cell (arrow).


Composite image of the Chest Radiographs of Patient 3 at initial evaluation (left) showing extensive miliary nodules.


Subsequent Chest radiograph (right) after six weeks of anti-tuberculosis treatment alone show profusion of nodules with diffuse ground-glass opacification. Worsening hypoxemia was clinically noted.


Side of Figure 5 , showing random nodules with fissural prominence, with beading in both oblique fissures, some interlobular septal thickening, and ,diffuse ground glass opacity can be seen.


Composite image of the HRCT image of Patient 3 at the level of major fissure during worsening hypoxemia corresponding to . . (Hematoxylin and Eosin stain, x 40) showing a non-necrotizing granuloma with peripheral lymphocyte cuffing.


Composite image of chest radiography images (left) of Patient 4 showing miliary nodules at diagnosis and photomicrographs of the lung biopsy specimen [right, Hematoxylin and Eosin stain (H & E) x 4] showing multiple perivascular granulomas (arrow).


Composite image of the HRCT image of Patient 4 showing. Upper lobes) random nodules with perilymphatic predominance, beading of the right oblique fissure, and ,perivascular nodules.


Lower lobes) marked interlobular septal thickening in the lower lobes associated with random nodules.


Karyotype. 46,XY,t(5;7;7) (q33.2; q32; q11.2). Arrows indicate the direction of the transfer of chromosomal material between the derivative chromosomes 5, 7 and 7.


Metaphase FISH using break apart probes for 3'PDGFRB (red signal) and 5'PDGFRB (green signal). Arrow A shows the normal chromosome 5 with an intact PDGFRB fusion signal (yellow). Arrow B shows the derivative chromosome 5 containing only the 3' portion of PDGFRB (red signal). Arrow C shows the derivative chromosome 7 with the translocated 5' portion of PDGFRB (green signal).


Whole chromosome 5 paint with green fluorescent probes. Arrow A shows the normal chromosome 5 with fluorescence label seen throughout the chromosome indicating intact chromosomal material. Arrow B shows the derivative chromosome 5; the unlabeled end of the long arm indicates the translocated chromosomal material from the derivative chromosome 7. Arrow C shows the derivative chromosome 7 containing translocated material from the der(5).


Whole chromosome 7 paint with red fluorescent probes. Arrow A shows the derivative chromosome 7. Arrow B shows the derivative chromosome 7 with the unlabeled part at the end indicating the translocated chromosomal material from the derivative chromosome 5. Arrow C shows the der(5) with translocated chromosomal material from der(7).


A; TV-PF visualized by FIESTA (bright-blood MRI imaging sequence) with hyperintense signal relative to the myocardium, but hypointensity relative to the blood pool.


B; Axial FIESTA sequence showing the same pedunculated tumor attached to the TV.


C, D Hyperintense tumor signal with inversion recovery T2 sequences and delayed gadolinium hyperenhancement.


Extraorally, a swelling was noticed on the left side of face.


Intraorally, the swelling was seen involving the left canine and extending up to the second premolar.


Radiograph showing well-defined radiolucency and resorption of teeth.


Photomicrograph showing the spindle cells arranged in herringbone pattern (H&E stain, x40).


Lesional cells showing positivity for vimentin (IHC stain, x200).


Few areas showing round cells (H& E stain, x400).


The lesional cells were separated from the overlying epithelium by a zone of connective tissue (H&E stain, x40).


Dysplastic spindle cells arranged in herringbone pattern (H&E stain, x200).


Optical coherence tomography showing an area with subretinal fluid leakage.


Fluorescein angiography showing the presence of significant pigment epithelial detachment in the perifoveal capillary network (venous phase) just before starting treatment with ranibizumab No polyps were observed.


C; Indocyanine green angiography performed 3 months later (after initial loading dose of ranibizumab 0.5 mg) showing 3 hyperfluorescent polyps in the superior papillary area of the right eye.


Optical coherence tomography at the follow-up visit 4 weeks after combination therapy with ranibizumab 0.5 mg and photodynamic therapy (right eye).


Optical coherence tomography performed 4 weeks after administration of the loading dose of aflibercept followed by half-fluence photodynamic therapy (right eye).


Ulcerated lesion in the perineal region, consistent with perianal Crohn's disease.


Abscess in the region of the large left vulvar lip and perianal fistulas, consistent with perianal Crohn s disease.


Nodular and infiltrative lesions in the inguinal region consistent with hidradenitis suppurative Hurley stage III.


Partial vulvectomy surgery to treat hidradenitis suppurative.


Appearance of the vulvar region after skin grafting and wound healing.


Preoperative magnetic resonance imaging (MRI) of the brain postcontrast T1-weighted MRI. Axial view.


Coronal view.


Sagittal view reveals multilobulated complex mass with both cystic and solid components again seen in the suprasellar region measuring 28.7 mm x 34.5 mm x 37.2 mm (AP by TR by CC).


Postoperative magnetic resonance imaging (MRI) of the brain postcontrast T1-weighted MRI. Axial view.


Sagittal view reveals partial resection of the previously seen suprasellar mass with decrease mass effect and trace postsurgical hemorrhage.


Pre-operative appearance of the lesion.


(A): Periodic acid-Schiff (PAS) staining revealed a non-keratinizing stratified squamous cell epithelium with interspersed goblet cells.


(B) 40x PAS stain shows multiple longitudinal and transverse cross-sections of hair shafts.