Hyperpigmented, verrucous patches on front following lines of Blaschko.


Similar lesions over back.


Lesions over scalp, resulting in linear bands of alopecia.


Progression of the macular edema can be seen on OCT scans of the right eye (findings were similar in the left eye). At presentation (a), a significant macular edema was demonstrated, with an epiretinal membrane and mild vitreal opacification.


Progression of the macular edema can be seen on OCT scans of the right eye (findings were similar in the left eye). Findings were stable at 3 months.


Progression of the macular edema can be seen on OCT scans of the right eye (findings were similar in the left eye). But a worsening of the macular edema was noted at 6 months treated with an intravitreal injection of triamcinolone acetonide.


Progression of the macular edema can be seen on OCT scans of the right eye (findings were similar in the left eye). Despite treatment and cessation of certolizumab, the macular edema persisted at 1 year (d).


Intraoral swelling involving the right maxilla.


OPG revealing thinning of coronoid process, highly marked coronoid notch and hypoplastic condyle on the right side.


(a) CT scan showing massive tumor of maxilla.


(b) CT scan showing tumor extending upward toward the base of the skull.


Clinical photograph showing intraoral soft tissue swelling in the left retromolar region bluish in colour with diffuse margins and stretched mucous membrane.


Computed Tomography (CT) scan showing a cystic lesion present medial to the angle of the mandible.


Contrast CT scan showing cystic lesion medial to the angle of the mandible measuring 1.5 cm x 2.6 cm.


Gross examination showing a cystic lesion, roughly oval in shape, creamish brown in color, and nodular surface.


Brain magnetic resonance imaging before initial endoscopic transsphenoidal surgery. Coronal.


Brain magnetic resonance imaging before initial endoscopic transsphenoidal surgery. Sagittal. Sections of T1-weighted images.


Brain magnetic resonance imaging before initial endoscopic transsphenoidal surgery. Sagittal T2-weighted image. Show a multilobular lesion compressing the optic chiasma upwards. No sphenoiditis can be detected.


Brain magnetic resonance imaging, 4 years after the initial operation Coronal.


Brain magnetic resonance imaging, 4 years after the initial operation sagittal. Sections of T1-weighted images. Thickened sphenoid sinus mucosa well enhanced by gadolinium is seen (arrow).


Just before the second surgery Coronal.


Just before the second surgery sagittal. Sections of T1-weighted images. Thickened sphenoid sinus mucosa well enhanced by gadolinium is seen (arrow).


Baseline color fundus photo of the right eye showing drop-shaped sub-internal limiting membrane hemorrhage at the fovea.


Fundus fluorescein angiography showing blocked fluorescence confirming the subinternal limiting membrane hemorrhage with otherwise normal findings.


Indocyanine green showing a hyper-fluorescent nodule at the edge of the blocked fluorescence due to subinternal limiting membrane hemorrhage.


Optical coherence tomography image (taken immediately after the onset of complaints by referring doctor) showing sub-internal limiting membrane hemorrhage with after shadowing and PEDs.


Optical coherence tomography through the fovea showing reducing sub-internal limiting membrane hemorrhage with after-shadowing along with increased sub-retinal fluid and small irregular notched PED.


MRI showing intradural mass lesion that is isointense on sagittal T1-weighted.


Hyperintense on sagittal T2-weighted.


Enhanced after gadolinium injection.


Follow-up imaging revealed a flow void lesion in the filum terminale region.


Intraoperative photograph of the filum terminale artery aneurysm.


Ultrasound sonography:. A well-capsulated heteroechoic round mass over the tail of epididymis, 4.7 x 3.5 cm in size.


Abundant tortuous vessels adjacent to the paratesticular tumor.


(c) The tumor had a rich blood supply on color Doppler sonography.


A white, grayish, well-circumscribed, solid tumor (4 x 3.5 cm) adherent to atrophic testis and epididymis (arrow: tumor; star: testis).


Typical bland spindle or stellate cells with little or no nuclear polymorphism and variably elongated cytoplasm set in a mucomyxoid stroma. Vascularity was variably composed of delicate to more hyalinized vessels. (hematoxylin, and ,eosin, magnification 200x).


Typical bland spindle or stellate cells with little or no nuclear polymorphism and variably elongated cytoplasm set in a mucomyxoid stroma. Typical cytoplasmic desmin.


Typical bland spindle or stellate cells with little or no nuclear polymorphism and variably elongated cytoplasm set in a mucomyxoid stroma. Smooth muscle actin. Immunopositivity (magnification 200x).


Nymph stage of Linguatula serrata isolated from patients in rural area of Isfahan city, Iran.


End anterior section of the nymph stage of Linguatula serrata containing two pairs of prominent hooks.


Membrane of nymph stage of Linguatula serrata with large spins on surface.


On immunohistochemistry tumor cells show positivity for:. Vimentin (x400).


HMB-45 (x400).


S-100 (x400).


Ki67 <2% (x100).


Fusion image in cross section. Image of peritoneal carcinomatosis of the patient.


Fusion image in axial cut. It is found that the mass is well-located behind the tracheabronchial axis.


Maximal intensity projection of our patient. Acquisition of broadcoast images realized 60 min after injection of 252 Megabecquerels of FDG-IBA in a vein of the right wrist. Visualization of the supra-diaphragmatic isolated hypermetabolism.


Sagittal cut, fusion image, 30 mm mass above aortic stock, maximum standardized uptake value of 12.8.


Generalized hydropic appearance.


Chest x-ray showing expanded cardiothymic silhouette and persistent pneumothorax despite chest tube insertion.


Enhanced computed tomography (CT) reveal one irregular hypoattenuating mass, 4.6x3.7 cm in size with unclear margins, involved the spleen vessels and located at the pancreatic tail. Arterial phase showed inhomogeneous enhancement of the lesion.


Enhanced computed tomography (CT) reveal one irregular hypoattenuating mass, 4.6x3.7 cm in size with unclear margins, involved the spleen vessels and located at the pancreatic tail. The portal venous phase showed a mass with ring enhancement.


Enhanced computed tomography (CT) reveal one irregular hypoattenuating mass, 4.6x3.7 cm in size with unclear margins, involved the spleen vessels and located at the pancreatic tail. In the delay phase, the ring enhancement of the lesion gradually de-enhanced.


Enhanced computed tomography (CT) reveal one irregular hypoattenuating mass, 4.6x3.7 cm in size with unclear margins, involved the spleen vessels and located at the pancreatic tail. The mass with ring enhancement in coronal view.


Preoperative MRI and PET/CT examination of the reported case. (A) The lesion of liver (one in the S6 of liver, another in the S8, white arrow) was hypointense in T1-weighted imaging.


Preoperative MRI and PET/CT examination of the reported case. The irregular lesion (white arrow) has slightly hyperintense in T2-weighted imaging.


Preoperative MRI and PET/CT examination of the reported case. Significantly enhanced lesions in the arterial dominant phase.


Preoperative MRI and PET/CT examination of the reported case. PET/CT presented hypermetabolic nodule measuring 2.3x1.4 cm (SUVmax=6.2) in pancreatic tail.


(A and B) Hematoxylin and eosin (H&E) staining revealed the tumors consisted of epidermoid cells, intermediate undifferentiated cells, and mucous cells.


(C-F) Immunohistochemical studies show positivity for P40 (Anti-P40 Antibody, MABS519-AF647), CK7 (Anti-Cytokeratin-7antibody, SAB5600093), P63 (Anti-P63 Antibody, HK5257) and AB-PAS (AB-PAS staining kit, HZ-0127), respectively.


(A and B) Targeted-gene sequencing showed PD-L1 expression in pancreatic tumor.


(C) Isotype-matched monoclonal antibodies were used for control staining and to confirm that the specificity of primary antibody binding.


(D) Targeted-gene sequencing showed the quantity of tumor mutation burden (TMB).


Chronic plaque psoriasis over left palm and right sole that has evolved from palmoplantar pustulosis.


Note plantar pustulosis lesions. Similar lesions were present over other palm/sole.


B-scan ultrasonography image of the patient's left eye obtained at the initial examination. The B-scan ultrasonography image revealed that the lesion in the left eye appeared to have high internal reflectivity.


Fundus photograph.


OCT image. Of the patient's left eye. A protruding lesion was observed with a homogenous shadow on the choroid and under the retina, which was complicated by surrounding exudative retinal detachment. OCT, optical coherence tomography.


Indocyanine green angiography image of the patient's left eye. Indocyanine green angiography revealed low fluorescence.


Indocyanine green angiography image of the patient's left eye. Filling delay. In the area corresponding to the tumor mass.


OCT image. Of the patient's left eye 2 months after the start of steroid pulse therapy showing that the choroidal granuloma had markedly decreased. In addition, the patient's corrected VA was found to have improved to 0.7. OCT, optical coherence tomography; VA, visual acuity.


Clinical appearance of the scalp: Diffuse crusting associated with multiple pustular, exudative, and erosive lesions.


After 1 week of the treatment with topical steroid.


Dense infiltrate of neutrophils and lymphocytes in reticular dermis and around hair follicles.


Pre-operative CT images: A) Large phlegmon in LUQ "star" with intra-luminal calcification "arrow". A large right kidney is also noted.


B) Note part of the ascending colon "arrow" is running behind the root of mesentery.


A) Extensive peritoneal disease with carpet-like thick mucoid deposits.


B) The D-J junction "black arrow" is right to the midline. The ascending colon "blue arrow" is coming partially behind the root of mesentery and then continues anteriorly as the transverse colon "yellow arrow.


The abnormal anatomy of the gut: A) Schematic representation of the malrotation margins of the en-bloc resection delineated with markings "- - - -". The A-D labeling to facilitate follow up on coming figures.


B) Another view with the transverse colon elevated upwards to reveal the vascular anatomy. A: artery. Sup: Superior. Rt: Right. Inf: inferior.


The improvised technique: A) After the en-bloc resection, the distal end of the transverse colon rotated from left to right and repositioned to reach the low rectum along the right side.


B) The rotation of the transverse colon involves the 2700 anti-clockwise rotation around the middle vascular pedicle. A: artery. Inf: inferior.


The final anatomy after re-construction: double barrel stoma created with proximal end of the transverse colon and ileum. The rotated end of the transverse colon is anastomosed to the low rectum in the new anatomical position.


Post operative Barium study. The flowing of contrast through the stoma demonstrates the new anatomy.


A; Sharply delineated erythematosquamous psoriatic plaques of the right leg before infliximab therapy in May 2008.


B; After the fourth infusion of infliximab at a dose of 5 mg/kg in February 2009, the psoriatic lesions on the right leg had almost disappeared.


Chronic and itchy skin lesions in the groin areas and the right hip. This skin condition had been treated for psoriasis for 5 years with topical steroid.


Intraoral photograph of case 1 showing dome shaped swelling present at 22.23 region with distal displacement of 22.


Maxillary occlusal radiograph of case 1 showing hazy radiolucency with one to two thin septa crossing lesion centrally at 22,23 region.


Gross specimen of excised soft tissue mass of case 1.


Histological picture of case 1 showing abundance of fusiform, stellate and round cells in myxoid tissue.


Extraoral photograph of case 2 showing swelling on right maxilla with obliteration of nasolabial fold.


Intraoral photograph of case 2 showing swelling at posterior maxilla of 14-18 region with buccal cortical plate expansion.


Orthopantomogram of case 2 showing poorly defined mixed radiolucent radiopaque area at right posterior maxilla with root piece of 17 and without root resorption of involved teeth.


Computed tomography image of case 2 showed a well-defined expansile mass with calcified matrix arising from the alveolar process of maxilla, extending into the maxillary sinus with destruction of the posterolateral wall of the sinus.


Histological picture of case 2 showing typical spindleshaped cells in a myxomatous stroma.


Scleral melting 1 month after pterygium surgery.


Amniotic membrane graft in place secured with absorbable sutures.


Three weeks following amniotic membrane (AM) graft: complete AM integration and local inflammation resolved.


EEC syndrome. Three-dimensional ultrasound in rendering mode demonstrates the lobster-claw hands (white arrow).


EEC syndrome. Three-dimensional ultrasound in rendering mode demonstrates the lobster-claw feet (white arrows).


EEC syndrome. Three-dimensional ultrasound in rendering mode demonstrates the left cleft lip (white arrow).


A 47-year-old female with a history of painless palpable mass within the left breast. Bilateral mammography showing an ill-defined mass in the left upper outer quadrant in keeping with biopsy-proven mammary angiomatosis (white arrow).


Three years later, the same patient represented with a history of recurrent left-sided palpable breast mass. Ultrasound of the left upper outer quadrant showing an irregular hypoechoic mass correlating with the mammographic abnormality and palpable lesion (white arrows).


(a-d) Seven years before the initial symptomatic breast presentation, the patient had been admitted to the hospital with a history of nausea, dizziness, and unsteady gait. Noncontrast computer tomography.


(a-d) Seven years before the initial symptomatic breast presentation, the patient had been admitted to the hospital with a history of nausea, dizziness, and unsteady gait. T2-weighted magnetic resonance imaging. Showed a well-defined posterior fossa cystic lesion in keeping with right-sided hemangioblastoma (white arrows).


(a-d) Seven years before the initial symptomatic breast presentation, the patient had been admitted to the hospital with a history of nausea, dizziness, and unsteady gait. Pre- and postcontrast T1-weighted coronal sequences (c and d) confirm the typical appearances of a hemangioblastoma, ie, a large cystic component and a small enhancing mural nodule (short white arrows). No enhancement evident in relation to the cystic component. Associated hydrocephalus also evident (long white arrows).


An arterio venous malformation present on the left palm and thumb diagnosed as arterio-venous malformation on ultrasonography.


Multiple papules (trichilemmomas) on the bridge of the nose.


Cluster of papules on the lower lip.


Papillomatous lesions on the dorsal surface of tongue.


Papules seen on the buccal mucosa.


Ultrasonography with color Doppler showing multiple nodules in the lobes of the thyroid.


Ultrasonography showing oval hypoechoic areas in the breast with smaller adjacent similar areas suggestive of multiple fibroadenomas.


Ultrasonography showing cystic area with nodular solid component in the left breast suggestive of an intracystic mass.


Multiple polypoid lesions having smooth overlying mucosa seen randomly distributed throughout the stomach and duodenum on upper GI endoscopy.


Magnetic resonance imaging scan showing an intramedullary well-circumscribed hemorrhagic lesion involving the spinal cord at the D9-D10 level, showing no significant postcontrast enhancement.


Perl's stain x100: Negative for iron.


HMB 45 x100: Positive.


S-100 x100: Positive.


EMA x100: Negative.


CD34 x100: Negative.


Ki-67 x100: Very low.


X-ray of the neck anteroposterior view, showing a soft-tissue mass in the right trapezius region (blue circle) with specks of calcification within the mass (purple rectangle).


X-ray of the neck lateral view showing a soft-tissue mass over lying the C6-T2 vertebra (blue circle).


Magnetic resonance imaging neck sagittal image T1 showing a nill-defined, lobulated lesion in the right trapezius muscle,C6-T2level.


Magnetic resonance imaging neck sagittal image-T1. The lesion is isointense with mild diffusion restriction. Multiple ovoid figures suggestive of neurocysticercosis.


Magnetic resonance imaging neck sagittal image-T2 showing ill-defined, lobulated lesion in the right trapezius muscle. The lesion appears heterogeneous. No hemorrhageor calcifications noted.


Magnetic resonance imaging neck sagittal short tau inversion recovery image showing heterogeneous lobulated lesion involving the right trapezius.


Magnetic resonance imaging neck, axial short tau inversion recovery image showing heterogeneous mass involving the right trapezius.


Magnetic resonance imaging neck, coronal short tau inversion recovery image showing heterogeneous lobulated lesion in the right trapezius.


Histopathological image showing spindle cellneoplasm, infiltrating into adjacent skeletal bundle with tissue reaction, mitotic figures.


Histopathological image showing the specimen positive for vimentin.


Intraoperative visualization of tumor with the patient in prone position showing the tumor extending from level of C6 vertebra to spine of scapula.


X-ray of the neck anteroposterior view,2 years post-operative,showing no evidence of recurrence.


X-ray of the neck lateral view, 2 years post-operative showing no evidence of recurrence of the tumor.


The "groove sign" on the right forearm of the patient.


It is possible to make folds on the patient's skin, which nowadays does not have the "peau d'orange" aspect.


Histology of a prolactin-producing pituitary tumor. Tumor with diffuse growth pattern of cells with elongated nuclei and inconspicuous nucleoli and moderate amount of slightly acidophilic cytoplasm [(A):HE 400x.


Histology of a prolactin-producing pituitary tumor. Prolactin expression in neoplastic cells [(B):400x.


Thyroid ultrasonography (A) showed a normal size gland, with heterogeneous texture and pseudonodular areas, without nodular lesions, suggesting thyroiditis. The color flow Doppler signal showed significantly increased vascularity with diffuse homogeneous distribution (thyroid inferno).


There was a markedly hyperfunctioning thyroid in scintigraphy (B), with homogeneous activity distribution and no focal areas suggestive of hyper- or hypoactive nodular formations. The radioactive iodine uptake was 70.2% at the end of 24 h, markedly elevated compared to normal range (10-30.


Panel (C) shows the evolution of thyroid function. After pituitary surgery in 2009 the patient developed secondary hypothyroidism and initiated LT4. She was admitted with primary hyperthyroidism in April 2015 and initiated MMI. During antithyroid drug withdrawal before scintigraphy, FT4 and FT3 re-increased above the reference range. MMI was progressively reduced after 6 months of treatment, but after withdrawal in October 2015, central hypothyroidism recurred and she resumed LT4 since March 2016. Abbreviations: LT4, levothyroxine; MMI, methimazole; FT4, free thyroxine; FT3, free triiodothyronine.


Evolution of serum prolactin levels over time and its relation with medical, surgical, and radiation therapy. *Samples not diluted.


Serial donor blood counts. (a) White blood cell counts.


Serial donor blood counts. (b) Hemoglobin and hematocrit levels.


Serial donor blood counts. (c) Platelet counts.


Acute fatty liver changes.


Fatty liver changes in liver.


Clinical and histopathological features of case 1. A; An 1.5 x 1.5 cm ulcer on the lateral corner of the left eye with a necrotic and fibrinoid surface.


Clinical and histopathological features of case 1. B; Histopathological examination of a biopsy specimen showed a dense, mixed-cell, dermal infiltrate with numerous neutrophilic granulocytes and some macrophages.


Clinical and histopathological features of case 1. C; Less necrotic and clean base as well as less inflammatory borders after 2 weeks of systemic corticosteroid therapy.


Clinical and histopathological features of case 2. A; Painful ulcer with violaceous, undermined borders on the left part of the lower lip.


Clinical and histopathological features of case 2. B; Stable remission after 4 months of treatment.


Clinical and histopathological features of case 2. C; After 48 h, all 7 testing sites showed erythematous papules up to 3 mm in diameter.


A; Clinical appearance of the lesion in 2014: an atrophic plaque with a violaceous border and two small ulcers (arrows).


B; Clinical appearance of the scald in 2011: a small ulcer indicated by a star ( ) healed without developing NL but left a slight depigmentation.


Computed tomography (CT) scan coronal view head with contrast. . Bilateral lacrimal glands appear large with mild increased enhancement.


Computed tomography (CT) scan sagittal view neck with contrast. . Bilateral left greater than right cervical jugular chain, level I, occipital and supraclavicular lymph nodes demonstrate heterogeneous enhancement and enlargement, largest demonstrating conglomeration and cystic changes along the left jugular chain measuring up to 8.5 cm in length of the conglomerate.


Histopathology of cervical lymph node. . Geographical necrosis with fibrinoid deposits and nuclear fragments with apoptotic cells. Surrounding this area are pale histiocytes and lymphocytes. Neutrophils and eosinophils are characteristically absent.


Left eye at presentation (down gaze).


Left eye at presentation (primary position).


Left eye post penetrating keratoplasty.


Left eye post lateral tarsorrhaphy.


Patient with considerably clear optical zone after penetrating keratoplasty.


Persistent epithelial defect 3 months after penetrating keratoplasty.


Persistent epithelial defect, fluorescein staining.


Corneal melting, 6 months later.


Child's scalp lesion, showing hair loss, pus discharge and crusting.


Calcinosis cutis on right arm characterized by multiple, hard to bony consistency, dermal to subcutaneous plaques.


Plain radiographs showing soft-tissue calcification along right arm.


Biopsy showing basal vacuolisation with melanin incontinence and dermal mucin deposition (H&E, original magnification x10).


MRI scan showing swollen mucosa in the bilateral maxillary sinus with fluid collection (arrow).


Histology of sinus mucosa showing extensive necrosis with branching aseptate hyphae and a few distorted hyphae (arrow).


Smear of sinus mucosal culture showing branching aseptate hyphae (arrow) suggestive of Rhizopus species (Lactophenol blue Calcofluor stain).


Resected right ureter with mass seen at its lower end.


Cystoscopic picture of the polypoidal mass protruding from the right ureteric orifice.


Histologically, mesonephric tubules lined by a single layer of bland cuboidal surrounding eosinophilic secretions. Cells had eosinophilic cytoplasm, small nuclei and no prominent nucleoli with thickened basement membrane. Stromal edema and inflammatory infiltrate were present.


Radiologic study showed a mass at the same location of former one in temporal lobe.


Tumor tissue with normal brain tissue (right upper part). Cellularity is high. Patternless distribution of malignant cells is obvious. (H & E stain, x100).


Histomorphologic view of tumor part shows rhabdoid cells beside spotty necrosis. (H & E stain, x100).


Immunohistochemistry staining for vimentin marker of tumor cells shows positive reaction (H & E stain, x400).


Immunohistochemistry staining for cytokeratin marker of tumor cells shows positive reaction (H & E stain, x400).


Touch preparation cytology of tumor shows noticeable rhabdoid cells (H & E stain, x400).


Frozen sectioning of the brain tumor (H & E stain, x100).


Submental swelling with "double chin" appearance.


Sublingual swelling.


Ultrasonography of submental swelling shows thick walled unilocular cystic swelling with fluid content and floating nonshadowing echogenic nodules like "stack of marbles.


Sublingual swelling shows unilocular cystic lesion with internal homogeneous particulate component.


Intraoperative picture of sublingual mass dissection and enucleation of epidermoid cyst.


Excised epidermoid cysts with intact capsule on the table.


The postoperative picture (c) shows postoperative scar underneath the tongue and disappearance of sublingual swelling.


Microscopic examination of the lesions showing stratified squamous epithelial lining with accumulated keratin and underlying fibrous tissue with small blood vessels in low and high magnification (a and b).


Contrast-enhanced computed tomography images showing the enlargement of the left kidney, renal pelvis, and ureter. And gas accumulation within the renal pelvis, ureter, and bladder The patient's right kidney is absent, and a thickened gastric wall can be observed (arrows).


Gas accumulation within the renal pelvis, ureter, and bladder The patient's right kidney is absent, and a thickened gastric wall can be observed (arrows).


Skin examination revealed multiple erythematous, tense bullae on the right knee.


On dermatological examination, there were erythematous, eroded bullous lesions with crusts and ulcerated areas with a diameter of 3-4 cm on the right leg.


Dermatological examination revealed multiple erythematous, tense bullae in both palms, on the extensor surface of the left hand and the extensor surface of the left foot.


Ranunculus arvensis.


CT scan showing soft tissue mass anterior to sternum.


MRI coronal view showing large pre-sternal mass.


MRI sagittal view- multicystic lesion.


PET CT showing FDG uptake in the mass and neck node.


Resected specimen.


Specimen showing multiple cystic and solid areas.


HPE consistent with papillary thyroid carcinoma. H & E stain.


Initial (Pre- IP therapy) radiological, laparoscopic and pathological picture. . A. MRI image with mucus filled appendix compressing the sigmoid lumen (arrow).


Initial (Pre- IP therapy) radiological, laparoscopic and pathological picture. . B. Omental caking.


Initial (Pre- IP therapy) radiological, laparoscopic and pathological picture. . C. Composite intra-operative picture showing omental mass and mucinous deposits all over abdomen.


Initial (Pre- IP therapy) radiological, laparoscopic and pathological picture. . D. Gross specimen picture of perforated appendix.


Post IP chemotherapy. . A. MRI imaging showing resolution of omental mass.


Post IP chemotherapy. . B. No tumor deposits in peritoneum and small bowel.


Post IP chemotherapy. . C. Normal small bowel mesentery.


Histological picture. . A. Appendix with high grade tumor cells after initial appendectomy. Microscopic examination (10x) of Omentum - without tumor cells (after CCRS). Acellular mucin in deposits (10x) with intense Alcian blue staining (after CCRS).


The extensive swelling on the left side of the face and neck.


Superficial engorged blood vessels and erosions with crustations, swelling is supported by the patient's hand.


Computed tomography scan of the face.


Histopathological features suggestive of aggressive angiomyxoma.


Panoramic radiograph showing diffuse rarefaction of the alveolar process and the hard palate.


Coronal computed tomography image showing thickening of mucosa and opacification maxillary antrum with anterior wall destruction.


Surgically excised maxilla.


Whole slide scan showing (arrowheads) vasculitis consistent with inflammatory response to mucor angioinvasion (H&E, original magnification x4).


H&E stained section showing dense inflammatory infiltrate chiefly composed of eosinophils and hyphae branching in right angle and obtuse angles, mucormycotic hyphae, surrounded by extensive necrotic debris. These morphological features define mucor (H&E, original magnification x100).


H&E section reveals numerous fungal hyphae which are aseptate, broad with obtuse angle branching, in right angle, typical of mucormycosis.


Postoperative wound healed uneventfully after surgical reconstruction.


A 6.6-year-old boy suffered an electric cautery ritual circumcision-related penile injury and presented with loss of the penile skin and the glans penis (
A.


After debridement.


The split-thickness skin graft survived completely as observed 1 month after surgery.


Dermatological and histopathological characteristics of pyoderma gangrenosum. Ulcerative lesions showing necrotic base, and ,erythematous-violaceous undermined borders on the right, and ,left breast, respectively.


Dermatological and histopathological characteristics of pyoderma gangrenosum. Skin histology revealing epidermal necrosis, and ,a dermal-hypodermal inflammatory infiltrate mainly consisting of neutrophils (haematoxylin-eosin, original magnification x 100) (in the box, a magnified detail of the inflammatory infiltrate).


Dermatological and histopathological characteristics of pyoderma gangrenosum. Partial healing after therapy with pulsed intravenous methylprednisolone, followed by the combination of prednisone, and ,cyclosporine given orally.


Dermatological and histopathological characteristics of pyoderma gangrenosum. Complete healing with hypertrophic aspects.


Neck ultrasonography performed at 12-month follow-up visit after thyroidectomy. (a) Transversal scan shows two adjacent left paratracheal lesions (arrows).


Neck ultrasonography performed at 12-month follow-up visit after thyroidectomy. These marked hypoechoic areas have ill-defined margins but not microcalcifications; (b) Longitudinal scan depicts the elongated shape of the paratracheal lesion (lateral one) and its parallel orientation to the dermis without deformation of surrounding tissues, unlike true focal masses.


Neck ultrasonography performed at 10-month follow-up visit after the second cycle of intravenous methylprednisolone treatment shows complete regression of the two hypoechoic areas in the thyroid bed.


Brain MRI images of the patient. Multiple lesions revealed with isointensity on T1WI.


Brain MRI images of the patient. , hypointensity on T2WI.


Brain MRI images of the patient. Surrounded by edema, hypointensity on DWI.


Brain MRI images of the patient. And irregular ring enhancement after injection of Gd-DTPA.


Lung and abdominal CT images of the patient. Multiple Lesions were found in bilateral lung.


Lung and abdominal CT images of the patient. And the liver.


Lung and abdominal CT images of the patient. The right adrenal gland (yellow arrow) was obviously thickened (D).


Follow-up CT images of the patient after 1-year albendazole therapy. Brain CT images revealed multiple lesions has slightly shrink and surrounding edema was slightly relieved (A-C).


Follow-up CT images of the patient after 1-year albendazole therapy. Abdominal CT images showed that the lesion in liver was obviously diminished accompanied with calcification (D,E).


Brown folliculocentric papules over the trunk and upper limbs.


Prominent papules over the posterior arm.


This illustration shows that the tip of the trocar retracted into the suprachoroidal space. . Notes: The air moved through the infusion cannula and pumped into the suprachoroidal space (white arrow) to lead to a severe and total suprachoroidal air (yellow arrows) without red reflex immediately (brown color: total air CD, light yellow color: lens). . Abbreviation: CD, choroid detachment.


The illustration displays severe pneumoconjunctiva with lots of subconjunctival air (light blue color) covering the peripheral cornea and blocking diffusion of suprachoroidal air through the gap of the sutured sclerotomies (brown color: iris, light yellow color: pupil).


(B) On postoperative day 2, just the upper peripheral CD with an obvious flat but thick choroid over the posterior pole appeared on horizontal view from B-scan. . Abbreviations: B-scan, brightness scan; CD, choroid detachment.


3D spoiled gradient-echo MRI image obtained at 55 min shows dilated lymphatics (arrow) reaching upto the groin.


T1-weighted axial.


STIR coronal. MR images showed heterogeneous intensity, containing mainly fat and also fibrous tissue.


Follow-up of right lung disease before and after immunotherapy. (a) Pulmonary right nodule, suggesting contralateral lung disease.


Follow-up of right lung disease before and after immunotherapy. (b) Complete lung response during nivolumab treatment.


Tissue specimen of primary tumor sample and brain metastases. (a) Immunohistochemistry stained with PD-L1 primary antibody (28-8 pharmaDx; Dako) in a pretreated formalinfixed paraffin-embedded tissue of primary lung tumor before treatment, exhibiting strong membrane staining in 100% of tumor cells (20x magnification).


Tissue specimen of primary tumor sample and brain metastases. (b) Cerebellar tissue specimen after complete resection.


Timeline of events since the diagnosis and summary of administered treatments.


The predominantly right vulval involvement with overlying sloughed skin and superficial crusting with maggot creeping through.


Photograph of same site after cleansing and removal of overlying sloughed skin showing ulcerated cavity full of maggots.


Cross section chest CT scan.


Coronal section chest CT scan. . Chest CT scan: revealed multifocal cavity lesions, most prominent in the apices, consolidative volume loss greatest in upper zones, right greater than left.


Coronal section chest CT scan. . Chest CT scan: revealed progressive airspace opacities and traction bronchiectasis in the right base with small right pleural effusion on the background of severe thick-walled cystic changes in the apices.


Coronal section chest CT scan. . Chest CT scan: revealed enlarged thick -walled cavities in the bilateral apices, worsening the cavitary lung disease.


A; Facial skin xerosis.


B; Large rhomboidal scales covering most of the body.


C; Dry skin with rhomboidal scales on the lower extremities.


D; Plantar hyperkeratosis.


A; Hyperorthokeratosis, absence of granular layer and reduced rete-papilla pattern (HE, x40).


B; Osseous HP.


Gall bladder polyp in ultrasonography.


Cut open specimen showing gall bladder polyp.


Clinical photograph showing erythematous papulonodular lesions on extensor aspect of forearms and arms.


Erythematous plaques with ill-defined irregular borders on back of arms and shoulders.


Histopathology showing superficial and deep periadnexal granulomatous inflammation with neutrophils around vessels. Few foci with fragmented acid fast bacilli (x100 magnification).


Magnetic resonance imaging revealed a mass lesion of heterogeneous intensity 5.2x5.7 cm in the left vaginal wall.


(A) Tumor section revealed a yellow/gray heterogeneous appearance without apparent necrosis.


(B) Microscopic examination showed a fascicular arrangement of spindle cells without nuclear atypia. Mitosis was not observed (H&E, x20).


The recovery of patient's skin and oral lesions within next weeks following withdrawal of the causative medication. Note hyperpigmentation of recovered lesions characteristic of fixed drug eruption. Patient's finger lesion.


The recovery of patient's skin and oral lesions within next weeks following withdrawal of the causative medication. Note hyperpigmentation of recovered lesions characteristic of fixed drug eruption. Upper lip lesion.


The recovery of patient's skin and oral lesions within next weeks following withdrawal of the causative medication. Note hyperpigmentation of recovered lesions characteristic of fixed drug eruption. Malleolar skin.


The recovery of patient's skin and oral lesions within next weeks following withdrawal of the causative medication. Note hyperpigmentation of recovered lesions characteristic of fixed drug eruption. Abdominal skin.


A 12-year-old boy with circumscribed alopecic patch on the scalp.


Close-up view of the lesion on shaving the scalp. There were no bony depressions; however, the mass had a bag of worms feel on palpation.


Histopathology picture (10x) showing proliferation of spindle cells in the dermis with an unremarkable epidermis.


Histopathology picture (40x) showing the multiple spindleshaped cells with elongated ovoid to curved nuclei, surrounded by ecstatic blood vessels a matrix with wire like collagenous fibers.


Blood agar: Smooth, tiny colonies initially which become chalky white after few days.


MacConkey Agar: Pink or colourless colonies.


Coronal view of MRI sacroiliac joints: (following completion of intensive phase treatment) There is reduction of oedema over right internal iliacus muscle, iliac bone and sacrum with normal right sacroiliac joint(white arrow).


Preoperative images of the recurrent dermoid cyst (a).


Note the subcutaneous swelling in the superolateral orbital area (white arrow) Fluid attenuated inversion recovery MR imaging (coronal) showed a well-circumscribed extracranial tumor component of 22 mm in diameter (b).


CT (coronal) showed a tract traversing through the sphenoid bone (c).


Intraoperative findings. Part of the tract was inadvertently damaged and greasy and whitish yellow tumor content spilled out (a).


Intraoperative findings. The bone around the tumor tract was drilled and the tract was dissected.


Intraoperative findings. , which ended in pouch at the surface of the dura.


A cystic lesion lined by an epidermal-like squamous epithelium contained several sebaceous glands, some of which continuous to the epithelium (a).


A ductal structure, traversing through the sphenoid bone, was lined by a thin squamous epithelium with seldom keratinization (b). H&E: Hematoxylin and eosin; Original magnification x40.


Photograph of the left thigh: an ulcerated and infected nodule.


Cytological atypia and mitotic activity were remarkable (HE x 400).


Immunoreactive positivity for CK7 (IHC x 400).


CT abdomen and pelvis with contrast (axial view) revealing significant inflammatory change in the right lower quadrant in the mesenteric fat surrounding the cecum (white arrow) and thickening of the cecal wall (dotted arrow).


CT abdomen and pelvis with contrast (sagittal view) revealing significant inflammatory change in the right lower quadrant in the mesenteric fat surrounding the cecum (white arrow) and thickening of the cecal wall (dotted arrow).


Clinical manifestations and H&E staining before diagnosis of syphilis. Thinning hair on the vertex with scattered erythema, and ,papules on the scalp.


Clinical manifestations and H&E staining before diagnosis of syphilis. Numerous scattered erythema, and ,papules on the face.


Clinical manifestations and H&E staining before diagnosis of syphilis. Lots of hypertrophic plaques with white scales on the occipital scalp, and ,neck.


Clinical manifestations and H&E staining before diagnosis of syphilis. Scattered erythema, and . Papules on the trunk.


Clinical manifestations and H&E staining before diagnosis of syphilis. Scattered erythema, and . Extremities , some of the lesions showed necrosis and escharosis. Hyperpigmentation was presented.


H&E staining shows PLEVA-like features before diagnosis of syphilis. H&E staining of an erythema of the neck. X 40.


H&E staining shows PLEVA-like features before diagnosis of syphilis. . X 100).


H&E staining shows PLEVA-like features before diagnosis of syphilis. H&E staining of an escharosis lesion of the back. X 40.


H&E staining shows PLEVA-like features before diagnosis of syphilis. . X 100). PLEVA-like histopathologic features such as hyperkeratosis in the epidermis, mild acanthosis, elongated rete ridges, vacuolization of the basal layer with exocytosis of inflammatory cells, lymphohistiocytic infiltration around the vascular plexus and red blood cells (RBC) extravasation in the dermis were noticed in the H&E staining figures.


Histologic sections of involved occipital lobe. Luxol Fast Blue/PAS stain, Panel A (20X) and Panel B (40X), showing perivenous demyelination (pink areas around vessels) in areas of macrophage infiltration (arrowheads). Neurofilament protein stain demonstrates axonal preservation (arrows) in these areas, Panel C (40X) and Panel D (100X). Perivenous macrophage infiltration (arrows) is highlighted by CD68 immunohistochemistry, Panel E (40X) and Panel F (100X) (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article).


Reticulated, reddish-brown pigmented patch with hyperkeratotic papules and small plaques on the right knee of a female patient.


Histopathology of EAI. Epidermis showing acanthosis, mild atypia of basal cells, hypergranulosis and orthohyperkeratosis, rare dyskeratotic cells, pigment incontinence and vacuolar degeneration of the basal layer (H&E, magnification x10).


Histopathology of EAI. , interface dermatitis, apoptotic keratinocytes, slightly dilated blood vessels with perivascular lymphocytic infiltration within the papillary dermis (H&E, magnification x20).


Coronary angiography and cerebral CT. Coronary angiography showed a total occlusion at the mid-left anterior descending branch (red arrow). (A) Cranial view.


Coronary angiography and cerebral CT. Coronary angiography showed a total occlusion at the mid-left anterior descending branch (red arrow). (B) Left cranial view.


Coronary angiography and cerebral CT. Coronary angiography showed a total occlusion at the mid-left anterior descending branch (red arrow). (C) Axial cerebral CT showed hypodensity in the right parietooccipital lobe, with two spotted hyperdense areas.


(a) Photomicrograph of the tumor showing distinctly two populations of cells, one of a high-grade glial cell types showing marked nuclear pleomorphism and multinucleated tumor giant cells merging with bundles of malignant spindle-shaped cells (H and E, x250). (b) Photomicrograph showing selective cells stained positive for glial fibrillary acidic protein (PAP, x450). (c) Photomicrograph showing vimentin positivity by both types of tumor cells ie, spindle-shaped cells and malignant glial cells with bizarre nuclei (PAP, x450).


Sagittal T1-postgadolinium contrast enhancement magnetic resonance imaging suggestive of two heterogeneously contrast enhancing intra-dural, extramedullary lesions at D11-L2 and S1-S2 spinal levels (arrows).


(a) Microphotograph of H and E section showing highly cellular tumor with focal endothelial proliferation along with small focus of necrosis (arrow) (H and E, x100). (b) Microphotograph of H and E section showing highly cellular tumor with pleomorphic cells and small foci of necrosis (arrow) (H and E, x100).


Ultrasound of neck showing enlarged supraclavicular and cervical and lymph nodes (Left side).


X-ray of the pelvis showing evidence of Looser's zone.


Low magnification view (panel a) demonstrating typical low-grade myxopapillary ependymoma including papillary appearance and fibrovascular cores. Other areas of tumor (panel b, shown under high magnification) demonstrate anaplasia and cellular atypia typical of high-grade tumor. Tumor specimen was diffusely positive for GFAP staining, indicating a neuronal differentiation, and demonstrated a high Ki-67 index (panels c and d, respectively).


The recurrent aspects of the case both pictures were self-taken, one on hard palate and the other on the lateral border of the tongue, with the purpose of showing the recurrent nature of the present case.


Histopathology of the incisional medical canthal biopsy specimen from the patient's right eye. A Hematoxylin-eosin staining of lymphoid follicles composed of small cells with mitotic figures and tingible body macrophages. (x 100 magnification) (b) Dense CD20 staining of B cells.


Histopathology of the incisional medical canthal biopsy specimen from the patient's right eye. A Hematoxylin-eosin staining of lymphoid follicles composed of small cells with mitotic figures and tingible body macrophages. (x 100 magnification) (c) CD3 staining of T cells within the follicles and in the interfollicular zones. (x 100 magnification).


Lesions involving:. Right buccal mucosa.


Left buccal mucosa.


Upper labial mucosa.


3 months post treatment showing significant reduction of lesions.


Histopathologic sections at 10x and 40x magnification: (A) 10x shows parakeratinized squamous epithelium with features of basal cell degeneration and juxtaepithelial intense chronic inflammatory cell infiltration.


The epithelium shows the presence of apoptotic bodies and characteristic saw tooth rete pegs; (B) 40x shows severe degeneration of basal cell layer with lymphocytic infiltration.


(a) Thick yellowish-white crusted plaques on the face (periorbital region), on admission.


(b) Thick yellowish-white crusted plaques on trunk, on admission.


Potassium hydroxide examination of crust showing scabies mite.


(a) Reduced crusting on face after oral ivermectin, two applications of topical permethrin (5%) cream, and topical keratolytics.


(b) Reduced crusting on trunk after oral ivermectin, two applications of topical permethrin (5%) cream and topical keratolytics.


Hemophagocytosis in the bone marrow. An activated macrophage engulfing blood cells; Papanicolaou's stain (oil immersion).


Leishmania sp. Amastigote in bone marrow aspiration; Papanicolaou's stain (oil immersion).


Preoperative axial T1-weighted.


Fluid-attenuated inversion recovery.


Diffusion-weighted.


Gadolinium-enhanced T1-weighted.


Magnetic resonance imaging shows a solid mass at the dorsal medulla oblongata The tumor shows prominent homogeneous enhancement with gadolinium.


(a-c) Three months after starting treatment, magnetic resonance imaging shows marked reductions in mass size on fluid-attenuated inversion recovery imaging and gadolinium-enhanced T1-weighted imaging (white arrows).


(d-f) All residual lesions have disappeared by the 1-year follow-up.


Wet mount examination of trophozoites of Balantidium coli.


Trichrome stained trophozoites of Balantidium coli.


Clinical course of a 23-year-old woman with refractory alopecia areata. . Note: Because of refractory alopecia areata, the patient was administered five courses of intralesional corticosteroid therapy and three courses of systemic corticosteroid pulse therapy. . Abbreviations: NB UVB, narrowband ultraviolet B; ONFH, osteonecrosis of the femoral head; SADBE, squaric acid dibutylester; THA, total hip arthroplasty.


Therapeutic effect of a 23-year-old woman with refractory alopecia areata. . Notes: Localized patch progressed to extensive alopecia areata despite the first systemic corticosteroid pulse therapy. Therapeutic effect after the topical, systemic, and oral corticosteroid therapy is shown. (A) Hair loss and alopecic eyebrow.


Therapeutic effect of a 23-year-old woman with refractory alopecia areata. . Notes: Localized patch progressed to extensive alopecia areata despite the first systemic corticosteroid pulse therapy. Therapeutic effect after the topical, systemic, and oral corticosteroid therapy is shown. (B) Extensive loss of hair on the crown of the head.


Radiographic images of the hips on high-dose corticosteroid therapy for refractory alopecia areata. . Notes: After the onset of right groin pain, (A) coronal view T1-weighted MRI shows characteristic low-signal band patterns (yellow arrows) on the bilateral femoral heads, which are suggestive of avascular necrosis.


Radiographic images of the hips on high-dose corticosteroid therapy for refractory alopecia areata. One year after diagnosis of bilateral osteonecrosis in the hip, (B) anterior-posterior radiograph shows massive broken and flattened (yellow arrows) subchondral bone of the right femoral head and progressive femoral head collapse. In the left femoral head, band-like sclerotic change (arrow heads) is observed.


Anterior-posterior radiograph of bilateral hips demonstrating cementless right total hip arthroplasty and left joint preservation following the surgery of core decompression and autologous bone graft.


Seller MRI scans showed a sellar lesion with suprasellar extension and compression of the optic chiasm. The lesion located in the sellar region presented with an isointense signal on T1-, and ,T2-weighted MRI.


Seller MRI scans showed a sellar lesion with suprasellar extension and compression of the optic chiasm. The mass was uniformly enhanced on MRI after contrast enhancement, and a pituitary adenoma was highly suspected.


Seller MRI scans showed a sellar lesion with suprasellar extension and compression of the optic chiasm. (E-H) The postoperative MRI showed total resection of the lesion.


Intra-operative conditions of the lesion. The dura of sellar floor was invaded by the tumor.


Intra-operative conditions of the lesion. The lesion was soft, mimicking pituitary adenoma in texture (the arrow).


Intra-operative conditions of the lesion. The dura of sphenoid platform was opened.


Intra-operative conditions of the lesion. The lesion was totally resected and the third ventricle was revealed. A, the invaded dura of the sellar floor; b, the cavernous sinus; c, the optic nerve; d, the sphenoid platform; e, the tumor; f, the arachnoid membrane of sphenoid platform; g, the optic chiasm; h, the mamillary body; i, posterior commissure.


(a) A 17-year-old male with an alopecic patch on his frontal area.


(b) A 2.5 cm x 3.5 cm well-circumscribed triangular alopecic patch with vellus hair. No atrophy, erythema, or inflammation was observed.


(a) After the first surgery, the lesion was slightly smaller than before.


(b) After the second surgery, there was no other abnormality except erythema of the incision line.


Brain imaging showing bilateral aneurysms. T1-weighted axial brain magnetic resonance (MR) scan showing large bilateral cavernous carotid aneurysms (CCAs), with a larger multilobulated aneurysmal sac on the right.


Brain imaging showing bilateral aneurysms. Brain computed tomography (CT) angiography showing large bilateral CAAs measuring approximately 21 x 17 x 16 mm on the right, and ,18 x 15 x 16 mm on the left.


Brain imaging showing bilateral aneurysms. MR and CT angiography confirming the presence of large bilateral CAAs, unchanged in size from previous scans.


Image of patient exhibiting edematous erythema, ulcer, and necrosis over the right nasal alae and upper lip.


Microscope image of biopsied lesion tissue showing numerous hyaline and septate hyphae with branches at acute angles scattered in the dermis (arrowhead) (periodic acid-Schiff, original magnification x 400).


Blood cell counts during hospitalization.


Presurgical intraoral picture.


Postsurgical intraoral view with immediate obturator in place and relined with soft liners.


Metal framework try-in, jaw relation, and denture try-in.


Timeline.


Family tree.


A pulmonary AVM as seen on echocardiogram.


Coronal CT images showing AVM on right and left side (arrow).


Angiosarcoma undifferentiated. Note the presence of anarchic vascular elements not very differentiated with mitoses (arrow) (HE, G X 200 and 400).


Factor VIII evidence in immunohistochemistry (arrow) (G X 400).


Evidence for CD34 tumor markers in immunohistochemistry (arrow) (G X 400).


Evidence for CD34 tumor markers in immunohistochemistry (G X 400).


Acute inflammatory edema manifesting as erythematous, edematous plaques on the lower abdomen and dependent parts of the lower extremities with sparing of the skin folds.


Histopathology shows perivascular, and ,interstitial inflammatory cell infiltration, predominantly in the markedly edematous papillary dermis (hematoxylin-eosin, original magnification x20).


Edema-phages, swelling or ballooning of histiocytes, containing either small or large clear vacuoles in their cytoplasm (hematoxylin-eosin, original magnification x400).


Numerous, large, irregular, thin-walled vascular channels lined by a single layer of flattened endothelial cells (hematoxylin-eosin, original magnification x40).


Immunohistochemistry reveals positive staining of the ectatic vessel endothelial cells with D2-40 (podoplanin) (original magnification x400).


A lower extremity nodular lesion.


The photos capture a lower extremity necrotic lesion in different stages of skin involvement.


The natural history of a right eyelid necrotizing lesion - early stage.


The natural history of a right eyelid necrotizing lesion - progression.


The natural history of a right eyelid necrotizing lesion - necrosis.


The natural history of a right eyelid necrotizing lesion - healing.


Bullous mucocutaneous lesions observed on the patient reported in the first case report. Lesions are shown at the initial.


Bullous mucocutaneous lesions observed on the patient reported in the first case report. Advanced. Stages.


Bullous mucocutaneous lesions observed on the patient reported in the second case report. Lesions are shown at the initial.


Bullous mucocutaneous lesions observed on the patient reported in the second case report. And advanced.


Slit-lamp photographs of upper eyelid.


Lower eyelid. Showing adult lice (red arrows) and operculated oval nits (yellow arrows).


Computed tomography (CT) and contrast-enhanced magnetic resonance imaging (MRI) were performed in June 2018 (A-E). CT images of brain window images demonstrated a well-demarcated mass with fat density in the left temporal lobe and cerebellar vermis with calcification (A,B).


Computed tomography (CT) and contrast-enhanced magnetic resonance imaging (MRI) were performed in June 2018 (A-E). MRI revealed a hyper- and isointense mixed mass on T1-weighted image.


Computed tomography (CT) and contrast-enhanced magnetic resonance imaging (MRI) were performed in June 2018 (A-E). And iso- and hyperintense mixed mass on T2-weighted image.


Computed tomography (CT) and contrast-enhanced magnetic resonance imaging (MRI) were performed in June 2018 (A-E). Gadolinium-enhanced T1-weighted image showed heterogeneous enhancement (E). The lesion in the cerebellum compressed the fourth ventricle.


Caused supratentorial obstructive hydrocephalus.


In 2013, the cerebellum lesion was relatively small.


Did not cause obstructive hydrocephalus.


Postoperative MRI indicated the cerebellar mass was near-totally removed (I).


Transthoracic echocardiography, parasternal long axis.


Transthoracic echocardiography, four chamber view.


Illustration of anatomy.


Preoperation.


Postoperation.


Electron microscopy findings. A; Part of a glomerulus showing epithelial foot process effacement, subendothelial, subepithelial and paramesanial EDDs. EDDs in the glomerular basement membrane (GBM) are observed (x4,600).


Electron microscopy findings. B; Massive EDDs in subendothelial, subepithelial and GBM. Hump-like subepithelial deposits are observed (x6,400).


Electron microscopy findings. C; A magnified glomerular capillary loop in Figure 3a. A large amount of EDDs in the subendothelial area (x6,400).


Electron microscopy findings. D; Unorganized and granular structure of EDDs (x10,000).


Fifteen year-old tattoo made of black pigment with erythematous and painful infiltrative reaction with papules and plaques.


Contrast CT-scans performed during targeted therapy. Showing enlarged mediastinal lymph nodes.


After the definitive suspension of treatment showing reduction in the diameter of the previously reported lymph nodes.


Right elbow MRI series showing a large heterogeneously enhancing and likely hemorrhagic mass with dilated vascular structures within the medial aspect of the distal biceps: axial view post-contrast.


Coronal view post-contrast.


Sagittal view.


Right elbow MRI. No evidence of soft tissue mass or abnormal marrow signal: axial view.


Right elbow MRI. , coronal view.


Right elbow MRI.sagittal view.


Adrenal metastasis with a blood filled appearance.


Image 1. Highly pleomorphic malignant epithelial cells of poorly differentiated non-small cell carcinoma. Numerous mitoses and areas of necrosis. H&Ex200. Image 2. TTF-1 positive staining. Neoplastic cells show a moderate to strong nuclear staining with TTF-1 in favour of adenocarcinoma and lung primary. TTF-1 immunoperoxidase x200.


Thoracoscopic approach: esophageal resection below the azygos vein arch.


Thoracoscopic approach: esophago-gastric termino-lateral mechanical anastomosis.


Esophagectomy specimen.


Computed tomography of abdomen demonstrating bilateral adrenal hemorrhage with right adrenal gland measuring 5.3 cm superior to inferior x3.4 cm transversely x3.8 cm anterior to posterior, and the left adrenal gland measuring 6.1 cm superior to inferior x4.3 cm transversely x5.4 cm anterior to posterior.


Physical sign of patient case 1.


A: CT without contrast showing moderate mucosal thickening.


B: CT venogram shows absence of enhancement of the right cavernous sinus.


A: Facial nerve involvment in case 3.


B: Big necrotic ulcer in the hard palate.


Initial slit-lamp image showing an 8 mm x 6 mm large pigmented lesion with numerous small cysts in the superior bulbar conjunctiva of the right eye.


(A) Color photograph of the surgical video after the application of topical anesthesia (five drops of a single dose of 0.4% oxybuprocaine hydrochloride).


(B and C) Subconjunctival anesthesia with 2% mepivacaine.


(D) The conjunctival tumor was resected using a wide excisional biopsy with a tumor safety distance of 2.0 mm. The resection was performed using the "no-touch" technique.


(E) The 12 mm x 10 mm conjunctival defect.


(F) The AM was placed with the stromal side facing down toward the defect. The AM was secured to the surrounding conjunctiva by five interrupted 9-0 Vicryl sutures. . Abbreviation: AM, amniotic membrane.


(A) Magnified slit-lamp image showing the pigmented lesion with numerous small cysts.


(B) Histopathological slide of the tumor stained with H&E, x20.


(C) Histopathological slide of the tumor stained with H&E, x50. Numerous nests of nevus cells containing abundant melanin pigment can be seen under the conjunctival epithelium. . Abbreviation: H&E, hematoxylin and eosin.


Slit-lamp images showing the course of healing over time. . Notes: (A) Slit-lamp image showing the large pigmented lesion before surgery.


Slit-lamp images showing the course of healing over time. (B) Seven days after the resection and AMT.


Slit-lamp images showing the course of healing over time. (C) A slit-lamp examination revealed stable findings 6 months after surgery. The AM has been partly integrated into the host tissue, while the ocular surface inflammation and corneal vascularization have decreased. . Abbreviations: AM, amniotic membrane; AMT, AM transplantation.


Painful, exuberant scaling and vesicular plaques upon presentation.


Skin lesions after treatment.


CT scan showing a large mass, 14.1x6.7 cm2 in size, in the anterior mediastinum. CT, computed tomography.


CT scan showing that the mass extends into the left thyroid gland. CT, computed tomography.


HE staining showing malignant mesenchymal tumor tissue. HE, hematoxylin-eosin.


Immunochemistry examination revealing EMA(+) tissue.


Immunochemistry examination revealing VIM(+) tissue.


Immunochemistry examination revealing CD99(+) tissue.


Immunochemistry examination revealing S100(+) tissue.


Follow-up CT subsequent to surgery showing a soft tissue mass of 5 cm in diameter found in the anterior mediastinum. CT, computed tomography.


Follow-up CT subsequent to chemotherapy revealing no mass in the mediastinum. CT, computed tomography.


Central retinal thickness of the right eye.


Left eye. As documented by optical coherence tomography at presentation - before treatment with intravitreal aflibercept.


Left eye. As documented by optical coherence tomography after treatment with 3 intravitreal aflibercept injections in each eye.


Panoramic FA findings).


Seven years after the first visit, the geometric lesion and CNV kept expanding steadily and new CNV developed at the inferior retina. Panoramic funduscopic findings.


Chronic oral candidiasis. Photo taken in February 2018) associated with diffuse inflammatory papules, and ,blepharitis along with cutaneous.


Skin biopsy (hematoxylin and eosin staining, x10). A mixed inflammatory infiltrate (arrow), without granuloma, related to pilosebaceous units, containing Demodex (star).


Pre-treatment extensive alopecia areata.


Pelvic x-rays showed a bilateral sacroiiitis grade 4.


Frontal view of the sacroiliac joints showing sarcoiliitis grade 4 of Forestier.


Chest x-rays showed mediastinal enlargement and a reticulonodular infiltrate in the middle and lower lungs.


A; Tomographic anterior corneal sagittal curvature map for OD.


B; Tomographic anterior corneal sagittal curvature map for OS.


C; AS-OCT epithelial thickness map for OD.


D; AS-OCT epithelial thickness map for OS.


A; Corneal and epithelial thickness measurements for OD and OS. Values correspond to averages from 4 AS-OCT acquisitions. All values are in micrometers. Mean and standard deviations are calculated for the 4 scans. CCT = Central corneal thickness; Min = minimum; Max = maximum; stdev = standard deviation; Min CT = minimum corneal thickness; Epi min = epithelial minimum thickness; Epi max = epithelial maximum thickness.


B; Graph showing epithelial thickness averages for the KCN group, as reported by Kanellopoulos et al. Using HF-UBM, and the respective epithelial thicknesses for OD and OS as measured by AS-OCT.


Glomerulus showing a cellular crescent with fibrinoid necrosis (Jones methenamine silver stain x 200).


Obsolescent glomerulus with adjacent multinucleated giant cell (H & E x 200).


Bright linear IgG staining of the glomerular capillary loops on immunofluorescence.


Necrotizing arteritis with transmural inflammation in the lung instertitium (H & E x 200).


Multinucleated giant cells in the lung (H & E x 400).


The patient had a reddish pigmentation left at the spot similar to this one. She had also received radium treatment for haemangioma at this site on the lower part of her abdomen.


Patient A: preoperative, axial T1 postcontrast weighted magnetic resonance (MRI) imaging showing enhancing disease.


Postoperative, axial T1 postcontrast weighted MRI imaging showing enhancing, residual disease.


Radiation therapy (RT) planning using volumetric arc therapy (VMAT) resulted in excellent coverage of the planning target volume (PTV) (red) by the 100% isodose line (yellow) corresponding to 5940 cGy.


Follow up gallium-68 dotatate positron emission tomography (PET) after more than 6 years showing hypermetabolic, recurrent disease in the left tentorial leaflet and physiologic uptake in the pituitary.


Patient B: preoperative, axial T1 postcontrast weighted MRI imaging showing enhancing disease.


Postoperative PET showing hypermetabolic, residual disease.


RT planning using VMAT resulted in excellent coverage of the 6000 cGy (red) and 5400 cGy (blue) PTVs by the 100% (yellow) and 90% (green) isodose lines, respectively.


Biallelic inactivation of BAP1 by differing mechanisms. Aligned sequence data from Patient A show the pathogenic BAP1 variant is heterozygous in the germline (top track) and tumor (bottom track).


Biallelic inactivation of BAP1 by differing mechanisms. ; the second hit is a somatic frameshift mutation.


Biallelic inactivation of BAP1 by differing mechanisms. In contrast, aligned sequence data from Patient B.


Biallelic inactivation of BAP1 by differing mechanisms. Show the germline variant approaching homozygosity in the tumor VarScan tumor allele frequency plot for heterozygous germline variants on chromosome 3 of Patient B indicates chromosome-level LOH across chromosome 3.


Solitary erythematous, slightly verrucous nodule, 3 cm in diameter, arising on a yellowish, verrucous plaque measuring 3 x 6 cm on the left frontoparietal scalp.


Histopathologic findings demonstrate mild epidermal papillomatosis associated with increased sebaceous gland and abortive hair follicles. HE. Original magnification x100.


Contrast-enhanced CT. . Notes: (A) Atrophic or dysgenetic left kidney.


Contrast-enhanced CT. (B and C) Papillary solid mass (arrows) growing from rectovesical excavation, compressing the bladder, sigmoid, and rectum. . Abbreviation: CT, computed tomography.


Adenocarcinoma of the seminal vesicles. . Notes: (A) Moderately differentiated adenocarcinoma of the seminal vesicles forming tubular structures and solid infiltration in the stroma.


Adenocarcinoma of the seminal vesicles. (B) Mature adenocarcinoma of the seminal vesicle. Magnification x100.


Left image: axial T2 FLAIR showing 2 cm x 2.3 cm left frontal mass with substantial edema. Middle image: sagittal T1 post-contrast image showing contrast enhancement in a "ring-like" pattern. Right image: axial T2 FLAIR showing residual changes consistent with partial resection of the previous ring-enhancing left frontal mass.


Pathological specimen of the left frontal lobe lesion. Left image: H&E section showing white matter with reactive gliosis (reactive astrocytes with abundant eosinophilic cytoplasm). Right image: Luxol fast blue showing absence of myelin.


(A) Sagittal T1 post-contrast showing large area of right occipitoparietal lesion with a ring-like enhancing pattern (left image) and axial T2 FLAIR MRI showing substantial peri-lesional edema (right image).


(B) Sagittal T1 post-contrast MRI showing marked increase in the size of the right parietal lobe lesion with surrounding local edema and enhancement.


Anatomo Physiological correlation between OCT Cirrus 4000 scan, Neurological Visual Field and Multifocal Electroretinogram. A; B-Scan of OCT Cirrus 4000 on foveal line of the right and left eye respectively (Red arrow shows the disruption of the photoreceptors). B; Neurological visual field of both eyes (Red arrow shows the limit of the peripheral scotoma and mild macular respect). C; Ganglion Cell Map of OCT Cirrus 4000 that shows a diffuse compromise of the ganglion cell with greater affection on the left eye. D; Multifocal electroretinogram that shows a diffuse compromise with a mild macular respect in both eyes. (Red arrow shows the limit of the functional and dysfunctional retina at macular level).


Specular microscopy shows the endothelial density with polymegathism and pleomorphism in both eyes.


Proliferation of fibrous and muscular tissue showing the presence of spindle-shaped cells with eosinophilic cytoplasm (H&E stain, x40).


The microphotograph depicts a high level of vimentin cytoplasmic expression (vimentin, x100).


The microphotograph depicts a high level of smooth muscle actin cytoplasmic expression (smooth muscle actin, x100).


The microphotograph depicts a high level of progesterone receptors intranuclear expression (progesterone receptors, x250).


A low level of estrogen receptors intranuclear expression is revealed (estrogen receptors, x250).


Low proliferative activity (Ki67) is revealed (Ki67, x40).


Psoriasiform papules and plaques over the palms.


Ill-defined psoriasiform plaques over the glans penis with peripheral collarette of scales.


(a) Psoriasiform hyperplasia and acanthosis of the epidermis. X10), and . (b) there is dense perivascular as well as diffuse lymphoplasmacytic infiltrate within the superficial dermis. X40).


Left arm, antecubital area, discrete, multiple well-demarcated, edematous, erythematous papules and plaques.


Face, frontal view. Leonine facies: Diffuse skin infiltration, multiple nodular lesions.


Histopathology, skin biopsy, taken from left arm. H&E staining 200 x magnification showing non-caseating granulomatous dermatitis.


Trends in WBC, serum creatinine, and albumin-corrected calcium over 10 hospital days. There is sustained improvement in WBC, creatinine, and calcium levels after administration of oral prednisone, as noted on hospital day 6.


A 6-year-old child with localized patch of hair loss on the occiput region of the scalp.


Dermoscopy in a patient with alopecia areata, presenting: Exclamation mark hair, dystrophic hair, black dots, short vellus hair, and yellow dots.


Dermoscopy in a patient with trichotillomania showing: Yellow dots with black dots, coiled hair, and short vellus hair.


Magnetic resonance imaging (T2 weighted, axial section) showing hyperintense mass lesion involving the adductor compartment of the left upper thigh.


Intraoperative findings of the lesion.


Photomicrography of chondroma with Hematoxylin and Eosin (H&E) stain showing mature hyaline cartilage (red arrows) with multiple foci of calcification (black arrows).


Vesiculopustular lesions localized to the face.


Multinucleated giant cells (Leishman stain, x100).


Healed lesions after antiviral therapy.


Two-year post-operative follow-up radiograph of the calcaneus showing curettage and cementing with Steinman pin reinforcement. There has been so sign of recurrence of disease or failure of the construct despite full activity.


Pre-operative radiograph of large lytic lesion in the calcaneus.


Preoperative sagittal T1 image of the calcaneus showing solid lesion with fairly homogenous signal.


Preoperative sagittal T2 image with some heterogeneity within the lesion surrounding bony edema, sclerotic border around the lesion, but with concern for cortical breakthrough in the subtalar joint.


Axial CT scan of lesion preoperatively displaying concern for cortical destruction.


H&E x200. The tumor consists of large epithelioid and spindle cells arranged in cords, clusters and as single cells within a myxoid to hyalinized stroma.


H&E x400. The tumor cells have moderately abundant eosinophilic cytoplasm with occasional cytoplasmic vacuoles. Nuclei are round with prominent nucleoli.


H&E x600. The vacuoles represent attempts at blood vessel formation and may contain red blood cell fragments.


CAMTA1 immunohistochemical stain, x200. Tumor cell nuclei stain positively with antibody to CAMTA1 protein, a fusion protein unique to this tumor.


CD34 immunohistochemical stain, x200. Tumor cells stain positively for endothelial marker CD34. This stain also highlights the anastomosing cord-like architecture of the tumor which recapitulates the formation of primitive blood vessels.


Color photographs of the left eye of the patient with uveitic crystalline maculopathy. Numerous foveal yellow-green hyper-reflective crystals could be observed in.


Color photographs of the left eye of the patient with uveitic crystalline maculopathy. And in the magnified view in.


X rays of the foot showing extensive osteomyelitis with tarsal, metatarsal and phalange bones destruction (arrows).


The resected specimen showing cavitis filled of yellowish materiel (arrow) corresponding to mycetoma grains.


Histological aspects (HES stained section) with a fractured colony destroying the bone tissue.


The histological image (HES stained section) showing a mycetoma colony with deeply basophilic outer layer and a pale center.


Histological image (PAS stained section) showing a positive staining colony.


Brain MRI. Axial T2w.


Brain MRI. ADC map.


Brain MRI. Gd T1w. Images. Extensive hyperintense mass in the left cerebellopontine angle extended upward into the cerebellum with lower peripheral ADC values and subtle peripheral linear irregular enhancement after gadolinium injection. The fourth ventricle, medulla oblongata and the cerebellum are dislocated and compressed.


Overview of haematopoietic bone marrow with a central granuloma. The arrows mark multinucleated giant cells. The inset shows a granuloma with the typical radially arranged fibres in the reticulin fibre stain.


Second intervention - Melanocytic anal lesion.


Day 1 post the 22nd RT session. Day 1 AQ serum therapy. Pain score =7. ARD grade 3.


Changes in absolute eosinophil count after initiation of clozapine use.


Slit lamp image of the left eye. Remarkable for corneal clouding, an inferior ulcer and hypopyon. Findings 3 days after aggressive lubrication and fortified topical antibiotics.


Contrast abdominal CT showed the pancreatic head [(A), red arrow] with the absence of the pancreatic body and tail.


Renal cortical cysts on bilateral kidneys were pointed out with blue arrows (B).


The gene sequencing showed a heterozygous mutation of HNF1B gene in exon 2 (c.513G>A) of the patient.


His father.


The sequencing of his mother was wild-type (E).


Left leg with dry skin marks 5 days after the accident.


Left leg with superficial dry necrosis with mild perifocal redness 9 days after the injury.


Left leg after radical debridement of the devitalized tissue with very deep, tunnel-like necrosis 14 after trauma.


Left leg after closing of all skin lesions by direct wound closure and by split-thickness skin graft.


Right poplit with a delayed deep necrosis 19 days after trauma.


Scars of both legs 8 weeks after the split-thickness skin graft of the left leg.


Short curly hair on the scalp.


Sparse hair in the temporal region.


Sparse eyebrow hair.


Trichonodosis and trichoschisis in light microscopy.


CT scan of the chest. CT of the thorax (horizontal section) showing a large mass measuring 4.6 x 12.0 x 8.1 cm, encasing the left pulmonary artery and segmental branches (arrows). The mass also abutts the left mainstem bronchus with partial encasement. Moderate-sized left pleural effusion (arrow heads).


Whole body PET scan using 18 F-FDG. PET scan shows a left upper thorax tumor mass (arrow) and metastases to left supraclavicular lymph nodes (arrow head).


CT scan of the abdomen. CT scan of the abdomen showing a distention of small bowel loops with several air-fluid levels.


Clinical appearance of the postoperative wound on the patient's lower abdomen. The ulcer had been sutured at the emergency department of our hospital 3 days before the patient's first consultation with the department of dermatology (a).


Clinical appearance of the postoperative wound on the patient's lower abdomen. On admission at the department of dermatology 6 days later, the suture had completely disappeared (b).


Clinical appearance of the postoperative wound on the patient's lower abdomen. After VAC therapy, the abdominal ulcer rapidly became granulated and reepithelialized (c).


Clinical appearance of the patient's left arm on admission. The patient presented with multiple scars and previous skin grafts on the extremities as well as a missing left lower leg. She did not reveal details of the causes of these wounds.


The correlation in radiation dose and recall radiation dermatitis that followed sorafenib prescription. . Notes: (A) Forty-eight Gy, in six fractions, was delivered by HT liver SBRT. The red area received 100%, the light-blue area received 50%, and the navy-blue area received 40% of the prescribed dose.


The correlation in radiation dose and recall radiation dermatitis that followed sorafenib prescription. (B) The photograph of the dermatitis that followed sorafenib prescription shows that it correlated with off-target dose area.


The correlation in radiation dose and recall radiation dermatitis that followed sorafenib prescription. (C) The photograph shows the recovered dermatitis after medical management. The white arrow shows the area that received 50% of the prescribed dose; the yellow arrow shows the area that received 40% of the prescribed dose. . Abbreviations: HT, helical tomotherapy; SBRT, liver stereotactic body radiotherapy.


The finding of magnetic resonance imaging. (A) Pre-SBRT, there was a local recurrence of HCC (white arrow) with thrombus extending into the IVC.


The finding of magnetic resonance imaging. (B) Post-SBRT, there was a partial response of the recurrent HCC (yellow arrow). . Abbreviations: HCC, hepatocellular carcinoma; IVC, inferior vena cava; SBRT, stereotactic body radiotherapy.


Lentigo maligna melanoma on the cheek and several non-melanoma skin cancers (NMSC) on the frontal region and nasal area.


Keratoacanthoma. A solitary and well-circumscribed, erythematous dome-shaped nodule with central crateriform keratin plug over the submandibular area.


Slit-lamp photograph of the right eye 3 years post- and intra-corneal ring segment implantation and corneal collagen cross-linking. Surrounding the intra-corneal stromal ring is dense clouding involving around 60% of the cornea, consistent with acute corneal hydrops (note the yttrium aluminium garnet laser peripheral iridotomy between 1 and 2 o'clock, as the patient was prepared for implantable collamer lens implantation).


(a) The forehead of the patient, showing papulonodular and plaque lesions.


(b) The scalp of the patient, showing scaly plaques and papulonodular lesions.


(c) The front view of the patient, showing multiple papulonodular lesions and plaques.


(d) The back view of the patient, showing papulonodular lesions, plaques, and some ulceration.


(a) A photomicrograph showing a dense diffuse lymphocytic infiltrate in the upper and mid dermis with no particular adnexotropism. The inset reveals these atypical lymphocytes mainly arranged in an interstitial pattern (H & E: 100x and 400x).


(b) A photomicrograph showing lymphocytic infiltrate weakly positive for T-cell marker CD8 (IHC: 400x).


(c) A photomicrograph showing lymphocytic infiltrate strongly positive for T-cell marker CD4 (IHC: 400x).


(d) A photomicrograph showing negative expression of B-cell marker CD20 (IHC: 400x).


Haematoxylin and eosin stain; original magnification 10x, alternating hyperkeratosis and parakeratosis.


Hemorrhagic bullae within pre-existing atrophic lesions involving her abdomen.


Preoperative photograph showing diffuse swelling over the left side of the lower face.


Intraoral photograph showing missing permanent left mandibular molars and a calcified, toothlike structure protruding from the alveolar mucosa over the retromolar region.


Orthopantomogram revealsa large, well-defined radiopaque lesion with focal radiolucent areas occupying the whole left body of the mandible. An impacted tooth is also visible. This appearance suggests that the lesion is a complex odontoma.


Intraoperative photograph after complete removal of the tumor.


The tumor specimen showing the presence of both calcified and epithelial components.


Reconstruction of the mandibular defect was done with iliac crest graft.


Photomicrograph stained with H and E reveals the presence of dense fibrous tissue and a few odontogenic epithelial cell islands. Fibrous tissue is of a primitive type containing spindle-shaped fibroblasts, some areas of hyalinization signifying dentin formation, and some clear spaces of enamel formation. In addition, odontogenic epithelial cells follicles are visualized with a few stellate cells suggestive of AFO.


Patient's lesions 1.


Patient's lesions 2.


Patient's lesions 3.


Histopathology.


Suture of the scleral flap.


Conjunctival graft.


Avascular bleb and visualization of the underlying uveal tissue.


Absence of scleral flap.


Tutopatch graft.


Conjunctiva over the graft.


After 8 months.


Clinical image showing diffuse swelling involving the tongue and lower lip.


The photomicrograph of the sections shows bundles of Schwann cells in myxomatous stroma (H&E stain, x100).


The photomicrograph showing tumor cells positive for S-100 protein (IHC stain, x100).


Showing multiple papules, pustules over the forearms.


A low-power histopathological photograph showing neutrophilic infiltration (arrow) around eccrine glands with necrosis.


A small swelling in relation to the mandibular canine and the mandibular right first premolar.


Intraoral periapical radiograph showing the absence of osseous involvement.


Hematoxylin and eosin sections showing numerous salivary gland lobules composed of normal-appearing serous acini and ducts along with sparse chronic inflammatory infiltrate.


Multiple well-defined nodules in the anterior two-thirds of the palate along and associated with the midline.


Occlusal radiograph showing a linear radiolucency in the midline of the palate displaced toward the left.


Hematoxylin and eosin section shows overlying stratified squamous epithelium and salivary gland lobules composed of normal-appearing, mucous acini, few ducts along with a sparse chronic inflammatory infiltrate in the deeper portion of the lamina propria.


Photomicrographs showing the representative histologic appearance of pulmonary blastoma. . Notes: (A) Malignant epithelial elements in undifferentiated mesenchymal stroma stained by H&E (200x).


Photomicrographs showing the representative histologic appearance of pulmonary blastoma. (B) The malignant glandular component was diffusely positive for the epithelial marker CK (40x).


Photomicrographs showing the representative histologic appearance of pulmonary blastoma. (C) The stromal blastematous malignant component was diffusely positive for mesenchymal stromal marker vimentin (100x). The yellow arrows indicate the positive cells stained by relevant markers. . Abbreviations: CK, cytokeratin; H&E, hematoxylin-eosin.


The IGV screenshots display the reads from next-generation sequencing and reveal harbouring of CD74-ROS1 fusion. . Note: Intron 7 of CD74 is joined with intron 33 of ROS1. . Abbreviation: IGV, Intergrative Genomics Viewer.


Magnetic resonance (MR) images in sagittal T2.


T1 coronal.


T1 coronal after contrast. Reveal a lesion in suprasellar cistern. It is characterized by heterogeneous hyperintensity in T2, with gross enhancement by gadolinium (arrow heads). Vascular structures are seen in the interior of lesion, with flow-voids (white arrows). It compresses and pushes anteriorly the optic chiasm, changing its sign (descontinuous arrow). Adenohypophysis is apart from the lesion (red arrow).


Coronal.


Sagittal. Postoperative skull computed tomography (CT) showing resection of tumor, hemostatic material in surgical bed (white arrows), pneumocranium (arrow head), and blood contente in left lateral fissure (red arrow).


Late (3 months) MR. Sagittal.


Late (3 months) MR. Axial.


Late (3 months) MR. Coronal. Images revealing residual tumor in surgical site.


Thoracic CT scan bullous lesion suspicious for a cavitation in the right lower lobe with multiple acinar opacities.


Gross findings. Micrognathia.


Gross findings. Clubbing fingers.


Gross findings. Slim extremities compared with trunk.


Linear brownish hyperkeratotic and sclerosing band on the skin. (A) Popliteal fossa.


Linear brownish hyperkeratotic and sclerosing band on the skin. (B) Antecubital fossa.


Histopathological findings of the skin. (A) Increased melanin pigments in the basal layer and sclerotic changes and telangiectasia in the upper dermis (H&E, x 40).


Histopathological findings of the skin. (B) Fragmentations of elastic fibers in the dermis (Elastic stain, x 200).


A single ulcer of 3 cm x 4 cm size with hyperpigmented irregular margins and slightly undermined nonindurated edges on the mons pubis extending to the upper part of vulva.


Indurated plaque of 1 cm x 2 cm at the site of venepuncture suggestive of pathergy phenomenon.


(a and b) Dense inflammatory infiltrate in dermis consisting of neutrophils, lymphocytes, plasma cells, and giant cells.


Healed ulcer at 1 month follow-up.


Crusting lesions in lips of an Uromastyx acanthinura with devrieseasis.


Lips in shedding after ceftazidime 20mg/kg every 48 hours for 57 days.


(a) MRI image shows focal nodular enhancement and thickening on cerebellar follia (arrows). Transaxial (b) and sagittal (c) images of PET, and transaxial PET/CT fusion images obtained 60 min after an intravenous injection of 370 MBq of 18F-FDG shows increased focal FDG accumulation on the surface of both cerebellar and cerebral hemispheres (arrows). 18 FDG PET/CT:. 18 fluorodeoxyglucose positron emission tomography/computerized tomography, MRI: Magnetic resonance imaging.


(a) Contrast axial images of MRI showing dural thickness and nodularities with contrast fixation of right and left cerebral leptomeninges (arrows).


Transaxial (b) Transaxial images of 18F - FDG PET showing increases lepromeningeal FDG uptake on the right and left cerebral hemisphers (arrows).


Microscopic histopathological examination image showing round to polygonal meningothelial cells with abundant clear cytoplasm arranged in a patternless pattern with prominent blocky perivascular and interstitial collagen bundles. Low power field).


High power field).


On formalin-fixed specimen, multinodular solid masses showed tan gray and fleshy cut surface. Multifocal hemorrhage and necrosis were seen.


Microscopic findings: tumor cells showed characteristic findings of "rhabdoid" cells such as infiltrative border. H&E, x200), eccentric nuclei, prominent nucleoli.


Characteristic eosinophilic inclusion or globules in abundant cytoplasm. H&E, x400) in nested tumor cells.


Immunohistochemically neoplastic cells expressed cytokeratin. X400).


Vimentin. X400).


Importantly neoplastic cells revealed absence of nuclear expression of INI 1 (E, x200).


Clinical intraoral image of the exophytic lesion in relation to lingual area.


Clinical intraoral image. The lesion was pedunculated involving the lingual mucogingival line and inserted on the keratinized mucosa.


Human wound myiasis caused by Chrysomya bezziana in a girl with pharyngostomy after removing the larvae (Original photo).


Prenatal ultrasound showing the neck mass.


Endotracheal tube displaced to the right position.


A. Sagittal MRI (T2) of the neck showing the teratoma.


B. Axial MRI (T2) of the neck showing the teratoma and the tracheal displacement.


The resected benign teratoma.


Fingerlike projection emerging from center of proximal nail fold.


Nonadherence to nail.


Excised tissue.


Postoperative wound healing.


MRI of the lumbar spine. (a) Sagittal postcontrast scan showing an enhancing mass at the L2-3 level.


MRI of the lumbar spine. (b) Axial postcontrast scan showing a right-sided mass extending into the right neural foramen causing foraminal expansion and canal stenosis.


MRI of the lumbar spine. (c) Axial T2 showing severe central stenosis.


Response to treatment. Primary tumor in the left lower lobe. Complete metabolic response to crizotinib as indicated by 18F-FDG-PET/CT scans before.


Response to treatment. Primary tumor in the left lower lobe. And after 4.5 months of treatment.


Response to treatment. Primary tumor in the left lower lobe. Partial response according to RECIST 1.1 criteria: tumor shrinkage from 33 to 13 mm before.


Response to treatment. Primary tumor in the left lower lobe. And after 4.5 months of crizotinib.


Patient having swelling in the cervical region, which was present since birth, and sinus in the thoracic region in midline.


Hyperpigmentation of face with hypertrichosis on the forehead and temples.


Erythrodontia.


Blisters on the dorsum of the hands.


Blisters on the feet.


Clinical photograph showing two extraoral deep necrotic ulcers on the right side.


Orthopantomograph showing irregular bone destruction from 44 to 48 with floating tooth appearance with 44, 45.


Removed maggots (Case 1).


Well-differentiated squamous cell carcinoma (x10). Section showing connective tissue infiltration by tumor cells and keratin pearls (Case 1).


Extensive necrotic wound with maggots.


Removed maggots (Case 2).


Poorly differentiated squamous cell carcinoma (x10). Section showing tumor epithelial cells infiltrating the stroma (Case 2).


Endoscopic examination of the nose showed a large, left-sided nasal polypoidal mass occluding the entire left nasal cavity with smooth overlying mucosa.


CT scan of the paranasal sinuses with contrast. The coronal section showed a left anterior lobulated nasal mass of undetermined origin at the level of the cartilaginous part of the nasal septum with mild heterogeneous post IV contrast enhancement.


Gross image of the mass revealed multiple fragments of soft to firm tan-gray tissue.


(a and b) Intraoral appearance of the wound showing pus discharge at the perforated mucosa in the anterior maxilla.


(c) The extracted maggot from the wound.


(d) Microscopic examination revealing five fingers like process in the anterior spiracle, incomplete peritreme in the posterior spiracle, and straight spiracular slits.


Erythematous feet.


Hands. At baseline with firm, nodular lesions in the beginning stages of development.


An example of extremities (C and D) during a symptom flare with progression of lesions to blisters and ulceration.


Demonstration of feet.


Hands. After successful treatment with clonidine and ketamine, and lesions in the process of healing.


Disease course before and after TSEB. . Notes: (A, D) Initial presentation of patient revealed only eczematous changes. (A-C) Progression of disease course in the face.


Disease course before and after TSEB. (B, E) Rapid disease progression within 3 months demonstrating multiple tumorous nodules throughout the body. (A-C) Progression of disease course in the face.


Disease course before and after TSEB. (C, F) Complete disease response after 3 months following TSEB. (A-C) Progression of disease course in the face.


Disease course before and after TSEB. . Notes: (A, D) Initial presentation of patient revealed only eczematous changes. (D-F) Progression of disease course in upper extremities. . Abbreviation: TSEB, total skin electron beam.


Disease course before and after TSEB. (B, E) Rapid disease progression within 3 months demonstrating multiple tumorous nodules throughout the body. (D-F) Progression of disease course in upper extremities. . Abbreviation: TSEB, total skin electron beam.


Disease course before and after TSEB. (C, F) Complete disease response after 3 months following TSEB. (D-F) Progression of disease course in upper extremities. . Abbreviation: TSEB, total skin electron beam.


Chest HRCT, transverse plane, initial examination. At the aortic arch level, a subpleural nodule in the apical S1+2 segments of the left upper lobe with pleural thickening in the adjacent area. Subpleural lesions are quite typical for necrotizing sarcoid granulomatosis (NSG) without predilection for upper or lower lobe involvement. In the right lung dorsally, a slight thickening of the pleura and of the major interlobar fissure.


Chest HRCT, initial examination, transversal plane at the level of lower lobes shows spherical nodules with smooth edges, with no apparent spiculations extending into the surrounding pulmonary parenchyma. A larger, 18 mm nodule in the S10 segment of the right lower lobe; a smaller one, 11 mm, in the S9 segment of the left lower lobe. Among frequent findings in NSG are nodular lesions with smooth or slightly irregular borders that may exhibit cavitations.


Chest HRCT, transverse plane, two-month follow-up. A tiny 'consolidation' of the pulmonary parenchyma with isolated calcifications and fibrous streaks extending towards the thickened pleura is present at the upper left lobe level in S1+2. The original S1+2 nodule adjacent to the pleura has partially regressed - a sign of a certain development of the disease over time.


Histopathological findings. Microscopically, confluent non-caseating granulomas with extensive necrosis are seen in the lung parenchyma. The granulomas are of the sarcoid type, palisaded by Langerhans-type giant cells and mononuclear lymphohistiocytes with central necrosis. Another typical finding is the presence of vasculitis, usually granulomatous, and a large zone of necrosis. Large zone of necroris (x50).


Histopathological findings. Microscopically, confluent non-caseating granulomas with extensive necrosis are seen in the lung parenchyma. The granulomas are of the sarcoid type, palisaded by Langerhans-type giant cells and mononuclear lymphohistiocytes with central necrosis. Another typical finding is the presence of vasculitis, usually granulomatous, and a large zone of necrosis. Granulomatous vasculitis (x100).


Histopathological findings. Microscopically, confluent non-caseating granulomas with extensive necrosis are seen in the lung parenchyma. The granulomas are of the sarcoid type, palisaded by Langerhans-type giant cells and mononuclear lymphohistiocytes with central necrosis. Another typical finding is the presence of vasculitis, usually granulomatous, and a large zone of necrosis. Confluent granulomas and vasculitis (x 100).


Chest HRCT, transverse plane, two-month follow-up. Compared with the initial examination, multiple nodules in the pulmonary parenchyma, predominantly in subpleural localization, have partially or completely disappeared. An 8 mm nodule (previously 18 mm) is present in S10 of the left lower lobe (indicated by the arrow).


Erythematous maculopapular eruption affecting the torso.


Patient at presentation following recurrence of epiphora 1 year after right external dacryocystorhinostomy.


MRI with T1.


T2. Weighting showing the presence of lacrimal sac mass at the time of presentation. The cavernous sinus is disease free.


T2-weighted MRI (a, b) showing the presence of a mass surrounding the internal carotid artery in the cavernous sinus 6 months following extensive cancer-clearing surgery.


The lesion is marked with arrow heads and enhanced with contrast and T1 imaging (c).


MRI of the left parotid mass.


MRI of the right parotid mass.


Histopathologic slide of intermediate-grade mucoepidermoid carcinoma of the left parotid gland (magnification, x200; hematoxylin-eosin stain).


Histopathologic slide of low-grade mucoepidermoid carcinoma of the right parotid gland (magnification, x200; hematoxylin-eosin stain).


After admission, the blood calcium level was 3.6 mmol/L. After 2000-4000 ml of NS for 5 days and salmon calcitonin (300 IU ivgtt), the blood calcium level gradually decreased and remained within the normal range. After surgery, the blood calcium level decreased, reaching the lowest level (1.65 mmol/L). After that, the calcium level was gradually restored to normal. There was a progressive decrease in the PTH level; however, the PTH level was stabilized at 50-60 pmol/L at 12 days post-admission, and this situation persisted for 1 week. One day post-operatively the PTH level rapidly decreased to 1.95 pmol/L, followed by a slow, gradual increase.


Case 1. Abundant thin colloid and follicular cells arranged in honeycombed and syncytial pattern (Diff-Quik, x200).


Case 1. Follicular cells with enlarged round to ovoid nuclei, focally overlapping nuclei, and nuclear grooves (Diff-Quik, x600).


Case 1. Follicular cells with occasional intranuclear inclusions (Diff-Quik, x600).


Case 1. Follicular cells with fine nuclear chromatin pattern and small eccentrically located nucleoli (Papanicolaou, x600).


Case 2. Follicular cells with enlarged round to ovoid overlapping nuclei and occasional nuclear grooves (Diff-Quik, x400).


Case 2. Follicular cells with focally enlarged round to ovoid nuclei and small nucleoli (Papanicolaou, x400).


Multiple papulonodular lesions of varying size over hands in a human immunodeficiency virus infected patient suffering from diffuse cutaneous leishmaniasis (case 1).


Multiple papulonodular lesions of varying size over elbow in an human immunodeficiency virus infected patient suffering from diffuse cutaneous leishmaniasis (case 2).


Color fundus photograph showing optic disc pallor and foveal atrophic changes in a bull's eye configuration in both eyes.


MRI scan of the orbit showing no evidence of active neuritis or infiltration of the optic nerves.


Fundus fluorescein angiography showing window defects with mottled hyperfluorescence in the parafoveal region in both eyes.


Lung cysts in a patient with Birt-Hogg-Dube syndrome.


Family tree of the index patient with Birt-Hogg-Dube syndrome.


Pleomorphic Xanthoastrocytoma. (A,B) Hematoxylin&Eosin staining shows a marked cellular pleomorphism, with the coexistence of several cell types.


Pleomorphic Xanthoastrocytoma. (C) Strong positivity for GFAP in immunohistochemistry.


Pleomorphic Xanthoastrocytoma. (D) Positivity for BRAF V600E in immunohistochemistry.


Sonogram of the left kidney of an emphysematous pyelonephritis patient at the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria, November 2019. Figure shows renomegaly, reduced renal parenchyma echogenicity and multiple irregular mixed echoes with dirty shadowing (blue arrow).


Contrast enhanced computed tomogram of an emphysematous pyelonephritis patient at the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria, November 2019. Figure shows left renomegaly, contrast enhancement and multiple air densities within the calyceal system (orange arrow).


Non-contrast-enhanced computed tomogram of an emphysematous pyelonephritis patient at the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria, November 2019. Figure shows left renomegaly with multiple air density area within the parenchyma and subcapsular region (orange arrows).


Painless bony hard swelling on the right maxilla, resulting in upward pushing of the right eyeball and eyelid.


Orthopantamograph showing a unilocular radiolucent lesion extending from 14 to 17.


Computed tomographic image showing a single large expansile radiolucent lesion with multiple radioopaque foci.


Computed tomographic image showing involvement of the maxillary sinus with the erosion of alveolar bone and medial, lateral and superior walls of the sinus.


Gross specimen showing a smooth, glistening, gelatinous, lobulated mass.


Schematic diagram describing timeline clinical, diagnostic and treatments features of suspected drug-associated (immune mediated) reaction in a 4-year-old male French bulldog. SPI, Staphylococcus pseudintermedius.


LMNA-NTRK1 fusion confirmed by RT-PCR. A; Schematic diagram showing the predicted in-frame LMNA-NTRK1 fusion protein joining the 5' LMNA filament domain to an intact 3' NTRK1 tyrosine kinase domain (KD). The red dashed lines denote the 1q chromosomal positions of LMNA and NTRK1, respectively.


LMNA-NTRK1 fusion confirmed by RT-PCR. B; RT-PCR Sanger sequencing trace confirming the fusion breakpoint at chr1:156100564 (LMNA, NM_005572.3, exon 2) and chr1:156844698 (NTRK1, NM_002529.3, exon 11). LTD, lamin tail domain; Ig, Tyrosine-protein kinase receptor C2 Ig-like domain.


Post treatment. Contrast-enhanced MR images demonstrating mass involving vertebrae. Axial.


Post treatment. Sagittal showing decrease in the size of the lesion compared to baseline (Fig.


Post treatment. 1). C; Gross specimen (sagittal) demonstrating a tan-white pink mass involving the paraspinal soft tissue and protruding into the underlying vertebrae body associated with sclerosis. Measurement bar = 1 cm.


Response to therapy as assessed by RECIST 1.1. Response plateau was achieved at week 12, with 45% decrease in size of the lesion.


(A and B) Pathological examination of the bone marrow including hematoxylin and eosin (H&E) staining revealed macrophages with intracytoplasmic microorganisms.


Axial computed tomography images showing expansion and thinning of the bony sinus wall that was absent at places.


Coronal computed tomography images: an unerupted maxillary canine was seen near the mesial wall.


Picture showing the bony window within the portion of the labial plate.


Enucleated specimen along with the embedded canine.


Gross examination revealed a cystic lesion measuring 6 cm x 5 cm x 4 cm.


Gross specimen showing tan-colored thickenings in the wall of the cystic lesion.