High-power view of the cell block highlighting background single-cell necrosis (arrows) admixed with the malignant lymphocytes. H&E. x40.


Images of Ki-67 staining indicating active cell division. (A) representative image for breast cancer tissue with Ki-67 staining. Zoomed in images for boxed regions in The scale bars are 400 and 100 mum, respectively.


Images of Ki-67 staining indicating active cell division.


Complex morphologies of CIC structures. (A) One cell was internalized.


Complex morphologies of CIC structures. (B) abnormal nucleus of the outer cell.


Complex morphologies of CIC structures. (C) Two cells were internalized, and the nucleus of one of them was missing.


Complex morphologies of CIC structures. (D) The cell enclosing two cells was inside of another cell (yellow arrow) without nucleus.


Complex morphologies of CIC structures. (E) Two cells were internalized, and the nucleus of the outer cell was deformed.


Complex morphologies of CIC structures. (F) Sequential internalization of three cells. Inserted pictures are schematic cartoons for the indicated CIC structures, respectively. Scale bar: 20 mum.


PET-CT showed multiple osteolytic bone destruction with increased metabolism, pathological fracture of the right third rib.


Eczema-like changes in the skin of the scrotum at the root of the penis.


The epidermis was eroded partly, and scattered, nested Paget's cells could be observed in the spinous layer with the dermal inflammatory cells infiltrated.


Calcification of the falx cerebri. Brain computed tomography scan showing lamellar calcifications of the falx cerebri (white arrow). A; Axial view.


Calcification of the falx cerebri. Brain computed tomography scan showing lamellar calcifications of the falx cerebri (white arrow). B; Sagittal view.


Pituitary MRI Coronal View. A; Coronal view.


Pituitary MRI Coronal View. B; Sagittal view.


Preoperative angiogram of the right upper extremity showing complete occlusion of the ulnar artery.


Lateral circumflex femoral arterial graft inset intraoperatively, measuring approximately 14 cm in length.


A close-up view of the reconstructed superficial palmar arch utilizing distal branches of the descending lateral circumflex femoral artery.


EWSR1 partners and tumors.


Photographs of. The palms of the hands showing normal skin.


The soles of the feet showing very slight hyperkeratosis.


Intraoral photographs showing. Severe gingival recession, and ,inflammation, especially in anterior region, and ,aggressive periodontitis.


Swelling related to the maxillary right missed canine region extending toward occlusal surface.


Panoramic radiograph showing severe destruction and loss of alveolar bone in both maxillary and mandibular arch, especially in the anterior region and anterior teeth appear as if floating in air without surrounding alveolar bone.


Photograph showing. Removal of the swelling.


Excisional biopsy of the swelling.


Histopathological image showing evidence of calcifications in the hypercellular fibroblastic stroma confirming the lesion as peripheral ossifying fibroma.


Follow-up photograph after 2 years showing loss of more teeth with no recurrence of the lesion.


Follow-up photographs after 2 years showing. Absence of change in the palms of the feet.


Slight increase in keratosis in the soles of the feet.


Twelve-lead electrocardiogram showing ventricular pacing rhythm at a heart rate of 80/min.


Previous MRI (a) High-resolution T2 MRI showing cerebral aqueduct stenosis/web.


(b) Axial FLAIR MRI showing abnormal signal in the optic chiasm extending to bilateral optic tracts and in the midbrain from the interpeduncular fossa extending between the red nuclei to the area of the oculomotor nuclei.


Preshunt adjustment axial T1 MRI demonstrating slit ventricles suggestive of shunt overdrainage.


Preshunt adjustment sagittal T2 MRI showing normal 4th ventricle and cistern spaces, no distortion of brainstem or splenium and no tonsillar herniation.


Five months postshunt adjustment looking straight ahead with no downward gaze preference, strabismus or ptosis. Subtle horizontal divergence.


Five months postshunt adjustment looking down. Left eye deviation laterally.


Five months postshunt adjustment attempting to look upward. Persistent upgaze limitation with lateral deviation of the left eye.


Alteration of fasting blood glucose level.


Serum triglyceride level. After intensive insulin therapy.


Clinical photograph showing essential infantile esotropia (OD).


Clinical photograph showing postaxial polydactyly of both hands.


Radiograph showing shortening of distal and middle phalanges as compared to proximal ones.


Showing oral candidiasis.


The finger nail changes.


Timing of major clinical features in APS type 1.


Patient's metaphase spread, with the arrow indicating the marker chromosome.


Results of PCR screening of marker chromosomes for XIST gene presence. Primers: CH3R/F on lines 1-5; CHXR/F on lines 6-8, 11, 12; XISTF/R on lines 13-17. DNA templates: chromosome 3 painting probe on lines 1, 6, 13; chromosome X painting probe on lines 2, 7, 14; microdissection-derived marker chromosome (mar1) on lines 3, 8, 15; microdissection-derived marker chromosome (mar2) on lines 4, 11, 16; negative controls on lines 5, 12, 17; 100 bp ladder on lines 9, 10, 18.


MR images obtained 2 weeks . Coronal T1-weighted image demonstrated intra-and suprasellar mass with a central area of high signal intensity consistent with hematoma of subacute phase. Compared with MR images obtained 2 weeks after onset.


MR images obtained 2 weeks . The hyperintense signal may correspond to hemoglobin degradation content as extracellular methhemoglobin,. Sagittal postgadolinium T1-weighted image showed rim enhancement of hematoma capsule.


3 weeks. After onset,. Coronal T1-weighted image demonstrated enlargement of pituitary hematoma resulting in compression of the chiasm (arrows). No sign of rebleeding was detected. The compression of chiasm was markedly worsened for this one week. Arrows).


Intraoperative microphotograph showing the content of hematoma. Xanthochromic fluid was spouted after dural opening (arrows).


Neuroradiological features. Brain MRI showed bilateral, symmetric signal abnormalities in the basal ganglia, and brain stem (A-C: T2-weighted images).


Sequencegrams. M.13513G>A was identified in the DNA of the patient (A).


Sequencegrams. The mutation was not found in DNA samples derived from his mother (B).


Typical cushingoid face of the patient.


Contrast enhanced computed tomography abdomen showed large lobulated necrotic hypodense enhancing lesion involving part of retroperitoneal space.


Gross image of a renal primitive neuroectodermal tumor. This specimen is notable for a variegated appearance. Select areas of the tumor feature a tan/brown or dark brown/red coloration, whereas other sections of the tumor feature a more yellow appearance, helping to illustrate the range of coloration observable on gross examination. This specimen is also notable for its lobulated appearance.


Generalized acne on the patient's face.


Wide purplish striae on the patient's abdomen.


Serial chest radiographs showing acute pulmonary oedema from her previous 4 admissions. Left pleural effusion with bat's wings appearance, and ,cardiomegaly.


Serial chest radiographs showing acute pulmonary oedema from her previous 4 admissions. Left pleural effusion with cardiomegaly.


Serial chest radiographs showing acute pulmonary oedema from her previous 4 admissions. Upper lobe diversion with bat's wings appearance, and ,cardiomegaly.


Serial chest radiographs showing acute pulmonary oedema from her previous 4 admissions. Left pleural effusion.


Lateral view of thoracolumbar X-ray showing the compression fracture at T9 to L1 spine with osteopenic bone.


Volumetric 3D reconstruction of the thoracolumbar spine from CT images showing compression fracture.


CT adrenal pre-contrast scan showing the right adrenal adenoma (blue arrow).


CT adrenal post-contrast scan showing the well-defined hypodense lesion at the medial limb of the right adrenal gland.


Serum enzyme trend during treatment with osimertinib after chemotherapy + pembrolizumab and concomitant steroid therapy. The modification of liver enzymes indicated grade (G) 3 liver injury, with important alterations in alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), aspartate transaminase (AST) and alanine transaminase (ALT). Although the interruption of osimertinib and the concomitant use of steroids reduced the altered enzyme values, an insufficient interval between the adverse event and osimertinib rechallenge rapidly induced new toxicity that took several days to resolve.


Cutaneous and mucosal involvement in Stevens-Johnson syndrome (day 45 of osimertinib). (A) Diffuse painful G3 erythema over the entire body upon hospital admission. The patient also had mucositis of the oral cavity (with blisters), pharynx (causing dysphagia), eyes, vagina, and nose (with ulcers causing episodes of epistaxis). SCORTEN score 3.


Cutaneous and mucosal involvement in Stevens-Johnson syndrome (day 45 of osimertinib). (B) Reduction in the diffuse erythema, with areas of flaking and depigmentation (day 60).


Frontal view of the child.


Charcot's joint.


Restricted mouth opening.


Dental caries in relation to 54 and 64.


Elli's class I fracture in relation to 11 and 21.


Dental caries involving the pulp in relation to 36.


Lateral cephalogram revealing the absence of tooth buds and severe mandibular prognathism.


Triple antibiotic paste filled in the pulp chamber and permanent restoration done for 36.


Composite restoration of maxillary central incisors.


A full thick excision skin biopsy and a nerve biopsy being performed.


Orthokeratotic squamous epithelium with papillomatosis.


Parotid fistula and Frey's syndrome.


The parotid region is divided into four quadrants. The injection points are at 1 cm from each other.


A de novo 3.1 Mb deletion on 14q13.1q21.1 was identified in the patient. The deletion encompasses 17 OMIM genes and the pLI (probability of LoF intolerant) value of each gene is shown in colors. The deletion shown is detected by CNV-seq.


A
) Chest X-ray of the patient showing pneumothorax on right side.


B
) Computed tomography revealing bilateral cysts and ground glass appearance.


Thoracoscopic image of cystic lesion.


Preoperative appearance of breast mass. Image of the breast lesion illustrating the superolateral fungating breast ulcer on a large, irregularly shaped, nodular breast mass.


Examination findings. 2A: an anterior image of the patient illustrating the limb deformity confined to the right side of the body with limb shortening and irregular angular deformity. 2B: a lateral image of the patient illustrating limb abnormalities. 2C: Image of the patient's right hand illustrating nodular prominences of the bones of the hand and fingers as well as finger shortening and irregular angular deformity.


CECT abdomen showing mass replacing the right ovary with nonvisualization of the uterus.


(a) Microphotograph showing islands of large polygonal tumor cells surrounded by lymphoid cells. The tumor cells possess clear cytoplasm and centrally placed nuclei with vesicular chromatin and prominent nucleoli.


(H&E 400x) and (b) Microphotograph showing tumor cells arranged in papillary fronds having vesicular coffee bean nuclei. (H&E 100x).


Chest X-ray showing asymmetric lobar opacities.


Transthoracic echocardiography. (a) Four-chamber view showing a tricuspid annular plane systolic excursion of 16 mm.


Transthoracic echocardiography. (b) Four-chamber view showing a mildly dilated right ventricle, with a telediastolic basal diameter of 42 mm.


Computed tomography showing a prominent hilar pulmonary vasculature and pulmonary ground-glass opacities.


Hysteroscopic picture - Endometrial adhesions.


Postadhesiolysis hysteroscopic picture.


Thin endometrium after removal of IUCD in preovulatory period.


Well-developed endometrium with low-resistance vascularity reaching zone 4.


Gestational sac, yolk sac, and embryonic pole after embryo transfer and positive beta-hCG test.


M-mode of cardiac activity of embryo.


3D picture of 8 weeks scan.


Preoperative view showing facial swellings and skin pigmentation.


Preoperative OPG showing the maxillary and mandibular lesions.


Computed tomography scan - Axial view.


Computed tomography scan - Coronal view.


Histopathology slide suggestive of Giant cell lesions.


Lesions exposed for curettage.


Decalcified freeze-dried bone powder used for filling the surgical defects.


Decalcified freeze-dried bone powder.


Mandibular defects filled with bone powder postcurettage.


Maxillary defects filled with bone powder postcurettage.


Postoperative OPG: At 2-week postenucleation.


Six months postoperative view.


Postoperative OPG: At 15 months postcalcitonin therapy.


Axial brain CT demonstrates left gyriform calcifications as well as bilateral cerebral atrophy and dilatation of both lateral ventricles that is more prominent on the left side.


Coronal brain MRI (T1 with contrast) demonstrates a dura-based mass in the left parasagittal posterior parietal region, with enhancement and surrounding vasogenic edema.


Coronal brain MRI (T1 with contrast) shows post-operative changes after resection of the meningioma. It also demonstrates asymmetrical dilatation of the lateral ventricles.


Left face lesions due to nevus sebaceous.


Left frontotemporal lipoma.


Preoperative MRI showing abnormal signal intensities on epidural dumbbell-shaped mass (measuring 25x18x24 mm) traversing the C1 to C2 interspinous space, compressing surrounding structures. The dumbbell-shaped lesion reveals isointense on sagittal T1-WI.


Preoperative MRI showing abnormal signal intensities on epidural dumbbell-shaped mass (measuring 25x18x24 mm) traversing the C1 to C2 interspinous space, compressing surrounding structures. , mixed hypointense on T2-WI.


Preoperative MRI showing abnormal signal intensities on epidural dumbbell-shaped mass (measuring 25x18x24 mm) traversing the C1 to C2 interspinous space, compressing surrounding structures.well-enhanced after gadolinium administration The spinal cord was compressed at the C2 level, and the signal change appeared on T2-WI. MRI : magnetic resonance images, WI : weighted image.


Post-operative CT scan. Partial hemilaminectomy, from the lower half of the C1 posterior arch to upper half of C2 spinous process, was performed. Mid-sagittal.


Post-operative CT scan. . 3-dimensional reconstruction).


Post-operative CT scan. C : Follow-up MRI with enhancement after postoperative 2 years reveals no residual and no recurrence. CT : computed tomography, MRI : magnetic resonance images.


Photomicrographs of the tumor reveals focal aggregation of cells with ample, clear, and foamy cytoplasm. There are large round cells with irregular vesicular nuclei. H&E, original magnification x200.


Gross finding of the tumor. A : External surface of the tumor; ovoid, yellowish, encapsulated with a white-colored adhesion scar at the mid-portion of the mass shown in the picture.


Gross finding of the tumor. B : Mid-section of the tumor, particularly yellow and white with cystic components.


Plain and enhanced CT findings. A 61 mm tumor in the posterior section was observed as. A low density area in the plain phase,. . A 10 mm tumor at the root of right hepatic vein was observed as. A low density area in the plain phase.


Plain and enhanced CT findings. A slightly high density area in the artery phase,. A high density area in the artery phase.


Plain and enhanced CT findings. A strong high density area in the portal phase, and . A high density area in the portal phase.


Plain and enhanced CT findings. An isodensity area in venous phase. An isodensity area in the venous phase.


Pathological and immunohistochemistry findings. Regarding the larger tumor,. Macroscopically, it measured 61 mm, and ,was white in color.


Pathological and immunohistochemistry findings. Microscopically, it had normal hepatocytes with mild sinusoidal dilation.


Pathological and immunohistochemistry findings. The hepatocytes were positive for CRP by immunohistochemistry.


Pathological and immunohistochemistry findings. . The smaller tumor measured 11 mm in diameter with. A white area, and ,an unclear margin.


Pathological and immunohistochemistry findings. Normal hepatocytes, and ,lymphocytes.


Pathological and immunohistochemistry findings. CRP-positive hepatocytes.


(A). Macroscopic view of skin-colored compressible protuberances in the cervical neck region simulating a lipoma (Blue arrow).


(B) Macroscopic view of the left side of the chest showing small, dark-blue venous nodules (Blue arrow).


(C,D) Axial gradient echo images, multiple lesions shown by red arrows.


Paraffin-embedded tissue samples from the right shoulder were deparaffinized and stained with anti-CD205 Ab.


Anti-CD163 Ab.


Anti-MMP-7 Ab.


Anti-MMP-28 Ab.


Anti-IL-17 Ab.


Or anti-IL-27 Ab The sections were developed with liquid permanent red. Original magnification: x200.


T2 weighted MRI showing an expansile lesion involving C2 vertebra with cord compression.


A; Pharyngoesophagography showed a large diverticulum retaining a meal rest (black arrows).


Ultrasonography showed a hypoechoic lesion containing echogenic foci (white arrows) suggesting a meal rest in the right lobe of the thyroid.


A hypoechoic lesion containing some small hyperechoic foci suggesting air bubbles (white arrowheads) in the left lobe of the thyroid.


D; Ultrasonography showed an isoechoic mass measuring 30.6 x 16.7 mm (black arrowheads) containing hyperechoic foci suggesting calcification in the left lobe of the thyroid.


Cervical CT findings. A; Coronal CT showed the bilateral hypopharyngeal diverticula (white arrows) protruding from the cervical esophagus laterally; the cervical nodule (white arrowheads) was located under the left diverticulum.


Cervical CT findings. B; Coronal CT showed that the left-sided hypopharyngeal diverticulum (white arrows) was located below the cricoid cartilage (black arrow).


Cervical CT findings. C; Axial CT showed that the thyroid tumor (white arrows) contained an isodensity area with a hyperdensity area that was suggestive of calcium deposition.


Pharyngoesophagographic findings. A; A large left-sided diverticulum and a small right-sided diverticulum were shown in the pharyngoesophageal junction and the thyroid tumor was pressing on the left-sided diverticulum and the cervical esophagus (black arrows) on the frontal projection.


Pharyngoesophagographic findings. B; A left-sided diverticulum was shown overlapping the anterior wall of the cervical esophagus in the lateral position.


Pharyngoesophagographic findings. C; Intraoperative view of the left side of the neck showed a left-sided hypopharyngeal diverticulum sac above the upper esophageal longitudinal muscle fibers (black arrows) that was mobilized from the left lobe of the thyroid and the thyroid tumor.


Pharyngoesophagographic findings. D; Schema of the posterior view of the hypopharynx and cervical esophagus. Zenker's diverticulum projects to the posterior wall of the esophagus between the inferior constrictor muscle and the cricopharyngeal muscle. The orifice is known as Killian's triangle. Killian-Jamieson diverticulum projects to the lateral wall of the esophagus between cricopharyngeal muscle and upper esophageal longitudinal muscle. The orifice is called Killian-Jamieson triangle.


A coronal T1-contrasted fast spin echo MR scans, and midline sagital 3D incoherent gradient echo MR scans 2 weeks prior to.


1 month following the operation.