A; Sagittal computed tomography angiography showing a left cerebellar hemisphere hemorrhage.


B; Thrombin generation curves obtained with 5pM tissue factor and 4 muM phospholipids (final concentration) in platelet-poor plasma using calibrated automated thrombin generation assay (Stago, Asnieres, France). The area under the thrombin generation curve (or endogenous thrombin potential) is significantly higher in the patient (red) compared to another subject with afibrinogenemia (blue) or a representative normal control (grey). In this patient with combined inherited antithrombin and fibrinogen deficiency, increased thrombin generation is due to insufficient inhibition of thrombin. Thrombin generation is decreased after infusion of 30 U/kg antithrombin concentrate (pink).


C; Visualization of the left coronary artery with computed tomography coronary angiogram showing 80% stenosis in the common trunk.


D; Visualization of the left coronary artery with computed tomography coronary angiogram showing 50% stenosis in the anterior interventricular branch of left coronary artery.


Clinical photograph showing swelling on the palate.


Computed tomography scan of patient.


Photograph of gross excisional tissue.


(a) The overlying epithelium is seen separated from follicles. The histological picture in this view gives the impression of reactive follicular hyperplasia of the lymphoid tissue (H and E, stain; original magnification, x2.5). (b) High-power view of the follicular pattern gives the impression of a reactive lesion (H and E, stain; original magnification, x10).


The large lymphoid cells show positive immunoreactivity for CD20, whereas the peripheral small lymphocytes are negative. Inset shows control stain (original magnification, x10).


The peripheral small lymphocytes show positive immunoreactivity for CD5, whereas the central large cells are negative. Inset shows control stain (original magnification, x10).


The peripheral small lymphocytes show positive immunoreactivity for Bcl2, whereas the central large cells are negative. Inset shows control stain (original magnification, x10).


Negative immunoreactivity for CD10 (original magnification, x10).


Immunohistochemistry profile showing very low Ki67 proliferative index (original magnification, x20).


MRI study of the abdomen revealed bilateral hydronephrosis due to severe stenosis of both right and left ureters at the pelvic-ureteral junction level (arrows).


A; Diffuse crescentic glomerulonephritis with large circumferential cellular crescents and severe compression of the glomerular tuft (periodic acid-Schiff stain; magnification x200).


B; Direct immunofluorescence staining shows linear glomerular basement membrane deposits of IgG (magnification x400).


Histological findings of GNET. Low power view shows a sheet like pattern with ulceration on the surface [(A), X100.


Histological findings of GNET. Patchy lymphocytic infiltration and multiple lymphoid follicles were observed in the tumor border near the serosa [(B), X100.


Histological findings of GNET. The neoplastic cells arranged in microcystic [, X200.


Histological findings of GNET. Papillary [, X100.


Histological findings of GNET. Fascicular [, X100.


Histological findings of GNET. Palisade [, X100.


Histological findings of GNET. Pseudoalveolar.


Histological findings of GNET. X200] or rosette like [, X200] pattern with eosinophilic cytoplasm.


Histological findings of GNET. Some areas showed epithelioid cells with clear cytoplasm [(I), X400.


Immunohistochemical and molecular findings of GNET. The neoplastic cells expressed S-100 [, X200.


Immunohistochemical and molecular findings of GNET. Intact SMARCA4(BRG1) [, X100.


Immunohistochemical and molecular findings of GNET. Syn [(C), X200] was focally positive.


Immunohistochemical and molecular findings of GNET. The Ki67 [(D), X200] proliferative index was low.


Immunohistochemical and molecular findings of GNET. Staining for pancytokeratin [(E), X200] was negative.


Immunohistochemical and molecular findings of GNET. FISH using EWSR1 break apart probe showed red and green split apart signals, suggesting EWSR1 gene rearrangement [(F), X1000.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. The neoplastic cells involved the mucosa [(A), X100.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. Higher magnification showed several glands [, X400.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. Noncohesive rhabdoid cells [, X400.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. Multiple necrosis [, X200], patchy lymphocytes.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. Plasma cells infiltration [, X400.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. Obvious mitotic figures [, X400.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. Multinucleated tumor cells [, X400.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. Large cells [, X400.


Histologic features of the SMARCA4-deficient undifferentiated carcinoma. Multiple lymphovascular permeation was present [(I), X400.


Immunohistochemical and molecular findings of the SMARCA4-deficient undifferentiated carcinoma. The tumor cells diffusely expressed pancytokeratin [, X200.


Immunohistochemical and molecular findings of the SMARCA4-deficient undifferentiated carcinoma. Vimentin [, X200] with paranuclear accentuation.


Immunohistochemical and molecular findings of the SMARCA4-deficient undifferentiated carcinoma. The Ki67 [(C), X200] proliferative index was high.


Immunohistochemical and molecular findings of the SMARCA4-deficient undifferentiated carcinoma. The tumor showed intact expression of INI1 [, X200.


Immunohistochemical and molecular findings of the SMARCA4-deficient undifferentiated carcinoma. Complete loss of SMARCA4(BRG1) [, X200, upper right.


Immunohistochemical and molecular findings of the SMARCA4-deficient undifferentiated carcinoma. No EWSR1 gene rearrangement was revealed by FISH [(F), X1000.


CT scan of the abdomen in 2018 showing large heterogenous enhancing right adrenal mass 11.0x9.8x14.8 cm (yellow arrow).


CT scan of thorax, abdomen, pelvis in 2018 revealing paraspinal mass (red arrow). Right kidney is displaced inferiorly by the huge right adrenal mass (yellow arrow).


CT scan of thorax, abdomen, pelvis in 2018 (sagittal view) showing paraspinal mass (red arrow).


CT scan of the abdomen in 2020 showing size reduction of the right adrenal mass 9.8 x 8.8 x 13.2 cm (yellow arrow) and paraspinal mass (red arrow).


(a and b) Computed tomography scan showing an osteolytic lesion of the left frontal bone, extending to the surrounding subgaleal soft tissues. An irregular left frontal lobe mass, below the bone defect, was also present.


(c) Three-dimensional computed tomography scan showing the frontal bone defect.


(d) Magnetic resonance examination showing the lesion with an irregular increased signal intensity on T1-weighted images and the coexistence of low- and high-signal components, suggesting different phases of intratumoral hemorrhage. After gadolinium administration, a slight peripheral enhancement was evident.


(e) Postoperative magnetic resonance imaging revealing the contrast enhancement of the dural layer with no residual tumor.


(f) Three-dimensional computed tomography scan showing the reconstruction of the bone defect.


Positron emission tomography/computed tomography image showing metabolically active hypo dense area encircling the superior vena cava right atrial junction.


Positron emission tomography/computed tomography revealing hyper metabolic nodule in the sub cutaneous planes of right thigh.


Histopathology of right testis showing microscopically shaved entrapped somniferous tubules in sheets of large monomorphic dyscohesive cells showing vesicular pleomorphic nuclei, clumped chromatin, small nucleoli, and minimal amount of cytoplasm suggesting primary testicular diffuse large B cell lymphoma.


(a) Lymphoid infiltrate in BMA. (b) Lymphoid infiltrate in BMB (H and E, 40x).


Changing trends of dasatinib dosage and platelet count from April 17, 2014 to March 13, 2015.


Pretreatment 2.5 cm contrast-enhancing mass in the right lower lobe (A).


Volumetric modulated arc therapy plan with the planning target volume (B).


Dose distribution with isodose lines, from 100% to 30% (C).


Complete tumor response 2 months after treatment (D).


CT on admission and 25 months after chemotherapy. Enhanced CT on admission revealed ring enhancement around the periphery of the tumors and heterogeneous enhancement within the tumors (a).


CT on admission and 25 months after chemotherapy. CT also revealed multiple hepatic tumors with heterogeneous enhancement, and a swollen lymph node surrounding the lesser curve of the stomach (b, arrowhead).


CT on admission and 25 months after chemotherapy. Thickening of the stomach wall was indicative of a gastric tumor that was thought to have invaded the muscularis propria (c, arrowheads).


CT on admission and 25 months after chemotherapy. MRI on admission showed enhancement at the periphery of the tumors and heterogeneous enhancement within the tumors in the arterial phase.


CT on admission and 25 months after chemotherapy. , but there was no enhancement during the delayed phase.


CT on admission and 25 months after chemotherapy. CT finding 25 months after chemotherapy showed a remarkable reduction in the size of the metastatic liver tumors without enhancement (f).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD before chemotherapy revealed a Bormann type 3 advanced tumor about 30 mm in diameter in the lower part of the stomach (a).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. Closer view of the gastric tumor (b).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD performed 8 months after chemotherapy showed a remarkable reduction in the size of the tumor, which had the appearance of an excavated lesion with marginal protrusion (c).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD performed 25 months after chemotherapy revealed an even greater reduction in the size of the tumor, which had the appearance of an extremely small elevated lesion with a scar (d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. HE staining revealed that the tumor was a poorly differentiated adenocarcinoma (a). Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. Immunohistochemical evaluation of a tumor biopsy specimen revealed that the tumor cells were positive for AFP Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. , PIVKA-II Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen.HER2 Original magnification x400 (a-d).


Preoperative intraoral view of the lesion.


Intraoperative view of the encapsulated lesion.


Specimen.


Cystic lumen with ghost cells and calcification (H&E, x100).


Connective tissue capsule with dentinoid tissue (H&E, x100).


Ghost cells with calcification (H&E, x100).


Tumor in the lateral part of the left temporal lobe and the cerebellum in magnetic resonance imaging (MRI) scans.


Necrotic area of the lung surrounded by atypical lymphoid cells.


Necrotic area of the lung surrounded by atypical lymphoid cells . . 20x.


Dense lymphocytic infiltration of the wall of the blood vessel. . 40x).


Positive immunostaining for CD20 ,. . 20x.


CD30. . 20x.


EBV/LMP1. Corresponding to grade 1 lymphomatoid granulomatosis (magnification A-10x. . 20x.


Dense infiltration of the brain composed of Reed-Sternberg cells, small lymphocytes, and macrophages. Corresponding to the classical Hodgkin lymphoma of the central nervous system, mixed cellularity (MCcHL).


Dense infiltration of the brain composed of Reed-Sternberg cells, small lymphocytes, and macrophages. Corresponding to the classical Hodgkin lymphoma of the central nervous system, mixed cellularity (MCcHL), and . . 40x.


Positive immunostaining for CD30 ,. . 20x).


CD20. . 20x).


EBV/LMP1. In Reed-Sternberg cells (objective magnification A-10x. . 20x).


Initial chest x-ray after onset of symptoms showing peribronchial vascular opacities in the left lung base and left perihilar region.


Chest x-ray 48 h after stopping clozapine (the second time) showing markedly improved lungs fields now almost completely clear.


CT findings: 5x4 cm right adrenal mass and 10x8.4x7.4 cm left adrenal mass with minimal surrounding inflammation.


Pathology report high-power view - positive for neoplastic lymphoma cells. High volume of lymphocytes showing high nuclear-cytoplasmic ratios (arrow).


Pathology report: Large B-cell lymphoma non-germinal center type. Neoplastic cells show diffuse reactivity for CD20 and for CD43. Background T cells are reactive for CD3. No reactivity for pan-cytokeratin, CD56, S-100 protein, chromogranin, synaptophysin, or TTF-1.


A 54-year-old female presented with gangrenous soft tissues over the forehead following an extensive polytrauma.


Debridement along demarcation margins was followed by trephination of the outer skull bones (black arrows).


An absorbable bi-layered polyurethane biomaterial was sutured onto the forehead defect sized 65 cm2 under minimal anesthesia.


2 weeks later, granulation ingrowth was observed within the scaffold overlying the periosteum (white arrow), while the scaffold overlying the bone was avascular (black arrow).


The changes of the levels of cytokines and CD123-CAR gene DNA, and the changes of the proportion of anti-CD123-CAR T-cells. (A) The serum levels of cytokines reached higher peaks 42 days after anti-CD123-CAR T-cell infusion or 14 days after radiotherapy.


The changes of the levels of cytokines and CD123-CAR gene DNA, and the changes of the proportion of anti-CD123-CAR T-cells. (B) The proportion of anti-CD123-CAR T-cells reached higher peaks 42 days after CAR-T cell infusion or 14 days after radiotherapy.


The changes of the levels of cytokines and CD123-CAR gene DNA, and the changes of the proportion of anti-CD123-CAR T-cells. (C) The trend of the CD123-CAR gene DNA level is the same as that of the anti-CD123-CAR T-cell proportion. . Abbreviation: DNA, deoxyribonucleic acid.


Platelet Trends with platelet values reported in thousands/uL for patient with suspected ITP. Day 1 - day 5 were hospitalization days, while days 8 - 46 were collected at outpatient follow-up appointments. Prednisone treatment was initiated on day 1. Day 5 corresponds to the first laboratory value after treatment with intravenous immunoglobulin.


Diffuse petechial rash on the patient's lower extremities (the right lower leg) - day two of hospitalization.


Magnetic resonance T1 image. A round-shaped, well-limited lesion, with contrast enhancement, located in the right striatum besides the the lateral ventricle with compressive effect on the brain parenchyma and adjacent structures deviation midline approximately 8.0 mm. Surrounding edema is observed.


Magnetic resonance imaging performed 2 years after the surgery. No residual or recurrent masses are identified; there are no signs of intracranial hypertension, no extra-axial collections, or deviations from the midline.


Skull film, lateral projection showed a rounded osteolytic lesion with a nonsclerotic rim in the left parietal bone.


Mast cell tryptase (MCT) level with the progression of symptoms and events over a 5-year period. Despite current elevations of MCT >19.5 mug L-1 in June 2016, the patient remains symptom-free with maintenance 150 mg omalizumab monthly and ongoing maintenance BV-SCIT. ^Omalizumab induction regime 150 mg, two doses, 2 weeks apart. *Reduced doses of antihistamines required with the introduction of omalizumab. Cetirizine 30 mg daily reduced to 10 mg daily and fexofenadine 720 mg daily to 180 mg daily. Prednisolone 50 mg weaned to 5 mg and then ceased.


Analysis of a CSF-470 VAC-SITE tissue. Dense clusters of CD11c+ cells were observed at the VAC-SITE, most of them also expressing PD-L1. Original magnifications = : 20X. Scale bars:. =200 mum.


Analysis of a CSF-470 VAC-SITE tissue. Dense clusters of CD11c+ cells were observed at the VAC-SITE, most of them also expressing PD-L1. : 100X. = 100 mum.


Analysis of a CSF-470 VAC-SITE tissue. Abundant CD68+ macrophages were also present in the area. Original magnifications = : 20X. Scale bars:. =200 mum.


Analysis of a CSF-470 VAC-SITE tissue. (E-G) CD8+ lymphocytes were mainly PD1- and many of them were proliferating (Ki67+). Original magnifications = : 20X. Scale bars:. =200 mum.


Analysis of a CSF-470 VAC-SITE tissue. (H,I) Numerous LMGC were observed by HE staining (arrows). : 100X. = 100 mum.


Analysis of a CSF-470 VAC-SITE tissue. (H,I) Numerous LMGC were observed by HE staining (arrows). : 1000X. = 20 mum.


Analysis of a CSF-470 VAC-SITE tissue. (J,K) The VAC-SITE was surrounded by numerous lymphatic and blood vessels (arrows). Original magnifications = : 20X. Scale bars:. =200 mum.


Analysis of C-MTS tissue. In the area of tumor regression (upper part of the biopsy), CD8.


Analysis of C-MTS tissue. And PD-1.


Analysis of C-MTS tissue. T lymphocytes were mainly present, while FOXP3+ Treg were scarce.


Analysis of C-MTS tissue. ; these lymphocytes were proliferating as determined by Ki-67+ staining.


Analysis of C-MTS tissue. Also, CD68+ macrophages.


Analysis of C-MTS tissue. CD11c Ag-presenting cells. Were mainly concentrated in this area.


Analysis of C-MTS tissue. In the lower part of the biopsy, MART-1.


Analysis of C-MTS tissue. PD-L1.


Analysis of C-MTS tissue. HLA class I +
 viable tumor cells were observed. Original magnification = 20X. Scale bars = 200 mum.


Metastatic spread of pheochromocytoma in abdominal CT.


Metastatic spread of pheochromocytoma in right liver lobe, right kidney, and right hemidiaphragm in abdominal MRI.


Abdominal CT scan after extensive surgery.


A perforation of the ulcer was observed in the gum on the bottom right jaw.


A) ABO and Rh blood group typing.


Agglutination with strength of 4+ in all cross-matching with erythrocytes of A1, A2,. And O blood group and anti-H lectin was negative.


Patient's timeline. At the top, the main treatments that the patient has received, with a focus on the anti-graft-versus-host disease (GVHD) therapies. Then, the blue arrow represents the timeline. In the red rectangles, the main diagnosis that the patient has received and the biological characteristics [Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph+ B-ALL) and donor cell myelodysplastic syndrome (DC-MDS)]. In green, the persistence of the complete response (CR) over time, even after the DC-MDS onset (red star). K, karyotype; IP, immunophenotype.


Cytomorphology of a bone marrow aspirate smear (x63) performed in August 2010 showing high-grade diffuse infiltration with atypical plasma cells.


Disease course based on M protein levels indicated in months after primary diagnosis (DX). Benda = Bendamustine; Len = lenalidomide; Dex = dexamethasone; Bort = bortezomib; Cyclo = cyclophosphamide; Mel = melphalan; Poma = pomalidomide; VCD = bortezomib/cyclophosphamide/dexa-methasone.


Radiograph of a pathological humeral fracture corresponding to serological disease progression in June 2011. Imaging after osteosynthesis with a proximally and distally fixed intramedullary nail.


The change of skin rash induced by cladribine in HCL, before.


After. Rescue. The diffuse, exfoliated, and itchy erythema (throughout the chest, back and limbs) gradually faded after a combination treatment with corticosteroids, immunoglobulin, ebastine, and sodium thiosulfate.


Trend of serum creatinine (mg/dL), estimated glomerular filtration rate (mL/min), and platelet count versus time in the presented patient. Green line = serum creatinine (mg/dL) (left y axis); black line = eGFR (mL/min) (left y axis); red line = platelet count (x1,000/muL) (right y axis); black box = peripartum thrombotic microangiopathy/atypical hemolytic uremic syndrome presentation; black arrow = date of therapeutic abortion; red arrow and box = start and duration of cyclophosphamide treatment; green box = start and duration of eculizumab treatment.


A: Interstitial fibrosis and tubular atrophy and glomeruli showing sclerosis associated with fibrous crescents (PAS, x 200).


B: Cellular crescent obliterating glomerular capillaries (H&E, x 200).


C: Cellular crescent replacing glomerular tuft. A few residual capillaries are evident (PAS, x 400).


Colonoscopy findings including Indigo carmine spraying. Ascending colon. . Notes: (A) Mass of the submucosal-like tumor.


Cecum. (B and C) Isolated small polypoid tumors. An abnormal microvascular tree was noted on the surface of these lesions.


Rectum). (B and C) Isolated small polypoid tumors. An abnormal microvascular tree was noted on the surface of these lesions.


IgH/BCL2 rearrangement by FISH analysis. . Notes:
IgH probe for 14q32 (green signals) and BCL2 probe for 18q21 (orange signals) and arrows (yellow signals) indicate IgH/BCL2 fusion. We detected IgH/BCL2 fusion in 95.2% of tumor cells. . Abbreviation: FISH, fluorescence in situ hybridization.


18F-FDG-PET/CT finding. . Notes: In the ascending colon, abnormal uptake that was consistent with malignant lymphoma was observed. SUVmax was 4.09. . Abbreviations: CT, computed tomography; 18F-FDG-PET, [fluorine-18]-fluorodeoxy-glucose-positron emission tomography; SUVmax, maximum standardized uptake value.


Bone marrow aspiration smear (May-Giemsa staining, x1,000). Note: The frequency of plasma cells was 30% of all nucleated cells.


Noncontrast computed tomographic scan revealed a multiloculated expansile cystic lesion with bony septae within, measuring 2.6 cm x 2.5 cm x 3.7 cm (AP x Tr x CC) in the region of the right angle of the mandible. Overlying cortex was thinned out with breaches of its integrity at places.


Magnetic resonance imaging of the lesion (axial sections) showed evidence of a 3.3 cm x 2.5 cm x 3.4 cm well-defined, expansile, mild to moderately enhancing lobulated T1 hypointense and T2 iso to hyperintense lesion in the right angle of the mandible with cortical thinning and cortical breaches, causing mild compression of the submandibular gland.


Magnetic resonance imaging of the lesion (coronal sections) revealing mild compression of the right submandibular gland by the expanding lesion of the right angle of the mandible.


Magnetic resonance imaging of the lesion (sagittal and axial sections) revealing multiple enlarged submandibular and cervical lymph nodes, especially in the posterior triangle.


Magnetic resonance angiography of the cervical vessels revealed no evidence of abnormal flow voids or abnormal draining channels, ruling out an arteriovenous malformation.


Esophagogastroduodenoscopy images of Case 1.


Esophagogastroduodenoscopy images of Case 1. : A diffuse miliary pattern of slightly whitish, small elevations was identified in the gastric body.


Esophagogastroduodenoscopy images of Case 1. (c): The elevations were emphasised on narrow-band imaging.


Esophagogastroduodenoscopy images of Case 1. (d): After indigo carmine spraying.


Pathological images of Case 1. (a): Follicle formation in a biopsy specimen.


Pathological images of Case 1. (b): Monomorphic lymphocytes.


Pathological images of Case 1. (c): Cells positive for CD20.


Pathological images of Case 1. (d): Negative for CD3.


Pathological images of Case 1. (e): CD10.


Pathological images of Case 1. (f): Cyclin D1.


Pathological images of Case 1.


Pathological images of Case 1. : Lymphoepithelial lesions.


Esophagogastroduodenoscopy images of Case 1. : Magnifying observation with narrow-band imaging.


Esophagogastroduodenoscopy images of Case 1. -: 3 months. Linked colour imaging also showed that the elevations regressed.


Esophagogastroduodenoscopy images of Case 1. (d): 45 months after eradication of H. Pylori. Small elevations disappeared and whitish spots could be partly observed in the gastric body. (d): Esophagogastroduodenoscopy performed 45 months after eradication of H. Pylori showed vague whitish spots in the gastric body.


Esophagogastroduodenoscopy images of Case 2.


Esophagogastroduodenoscopy images of Case 2. : After indigo carmine spraying] Slightly whitish, small, multiple elevations can be seen in the lesser curvature of the gastric body.


Esophagogastroduodenoscopy images of Case 2. : The small elevations regressed 5 months after H. Pylori eradication.


Pathological images in Case 2.


Pathological images in Case 2. : Haematoxylin and eosin staining of a biopsy specimen.


Pathological images in Case 2. (c): Cells positive for CD20.


Pathological images in Case 2. (d): Negative for CD3.


Pathological images in Case 2. (e): CD10.


Pathological images in Case 2. (f): Cyclin D1.


Esophagogastroduodenoscopy images of Case 2 performed 29 months after the initial examination.


Esophagogastroduodenoscopy images of Case 2 performed 29 months after the initial examination. : After indigo carmine spraying] Miliary appearance re-emerged in the gastric body.


Esophagogastroduodenoscopy images of Case 2 performed 29 months after the initial examination. (c): Magnifying observation with narrow-band imaging showed small elevations.


Esophagogastroduodenoscopy images of Case 2 performed 29 months after the initial examination. : After indigo carmine spraying] Granular appearance was not evident in the antrum.


Pathological images of Case 2. (a) Haematoxylin and eosin staining of a biopsy specimen.


Pathological images of Case 2. (b): Cells negative for CD3.


Pathological images of Case 2. (c) Positive for CD20.


Pathological images of Case 2. [(d) arrow and arrowhead]: Lymphoepithelial lesions were noted in cytokeratin AE1/AE3 staining.


Pathological images of Case 2. (e): Magnified views of arrow.


Pathological images of Case 2. (f): Arrowhead.


Axial T2-weighted MR images (a, c) show numerous abscesses in the liver (arrows) and pylephlebitis in the intrahepatic branches of the main portal vein (arrowheads).


Axial diffusion-weighted MR images (b, d) show high signal intensity in the abscesses (arrows) and pylephlebitis (arrowheads) due to restricted water diffusion.


(a) Follow-up axial contrast-enhanced T1-weighted MR image shows resolution of liver abscesses and improvement of pylephlebitis with a stricture in the portal branch of the right anterior liver segment (arrowhead), causing inhomogeneous enhancement of the hepatic parenchyma (arrows).


(b) No FDG uptake was seen on 18F-FDG PET/CT.


Photomicrograph of left axillary lymph node biopsy. Shows progressive transformed germinal centre, and ,loss of normal architecture (haematoxylin, and ,eosin stain, x10).


Shows small lymphocytes, histiocytes and immunoblasts (haematoxylin and eosin stain, x40).


Computed tomography (CT) manifestation of recurrent pulmonary infection. The recurrent pneumonia was observed during the hospitalization.


Computed tomography (CT) manifestation of recurrent pulmonary infection.could be relieved by multiple antibiotic treatments.


Computed tomography (CT) manifestation of recurrent pulmonary infection.


Computed tomography (CT) manifestation of recurrent pulmonary infection. Showed exacerbation of infection before the detection of mycobacterium kansasii (with air bronchogram and pulmonary consolidation), and the situation did not get improved after multiple treatments.


Dark red, necrotic, slightly tender lesions developed symmetrically on MCP joints and knees.


Hematoxylin and eosin (HE) staining shows blood vessels (white areas) with surrounding neutrophilic inflammatory aggregates (arrows), establishing the diagnosis of neutrophilic vasculitis. Picture magnification: 20x; scale bar: 50 mu.


Radiologic findings in the patient at the age of 9 months. Axial contrast-enhanced computed tomography shows left cervical adenopathy (arrows).


Immunohistochemistry findings. A cervical lymph node biopsy specimen displays nodal involvement by RDD. Immunohistochemical staining for S-100(+) is positive.


Immunohistochemistry findings. A cervical lymph node biopsy specimen displays nodal involvement by RDD. , while staining for CD1a is negative (original magnification, x400).


Electron microscopic findings at 7 years. Nodular deposits (arrows) are shown in mesangial, endocapillary, and subepithelial areas (original magnification, x7,000).


Pelvis X-ray showing osteolytic lesions secondary to bone resorption (red arrows).


Thorax CT scan: pulmonary alveolar calcification.


Contrast CT of abdomen.


MIBG scan.


Tumour abutting the renal hilum.


Resolution of lesions on the abdomen.


Case (1): FDG PET/CT showing intramedullary and extramedullary involvement: MIP image.


Sagittal CT.


Sagittal fused.


Transaxial CT.


Transaxial fused. Images showing multiple intramedullary lesions in bilateral humerus and femur (red arrowheads), multiple newly developed FDG-avid subcutaneous nodules in the right upper chest wall (green arrowhead) and right lower renal pole lesion (blue arrowhead).


Case (3): FDG PET/CT showing extramedullary involvement: maximum intensity projection (MIP) image.


Coronal CT.


Coronal fused.


Transaxial fused images. Showing multiple enlarged left axillary and supracalvicular lymph nodes (red arrowheads), left humeral head and neck lesion (green arrowhead), intramuscular involvements (blue arrowheads), FDG-avid peripancreatic lymph node (yellow arrowhead) and paracardiac lymph node (orange arrowhead).


Case (3): Lymph node biopsy showed diffuse sheets of PCs with many plasmablasts, scattered anaplastic forms and significantly increased mitotic figures (H & E 20x) (A).


The neoplastic PCs are positive for CD138 immunostain.


Peripheral smear under oil immersion.


Bone marrow smear showing blasts negative for myeloperoxidase.


(c) Bone marrow blasts negative for periodic acid Schiff.


Blast cells positive for t(8:21) (q22,q22) in all metaphases.


(a) Contrast showing isointense infiltrates to muscle; more pronounced on the right and bilateral proptosis (arrow).


(b) Soft tissue density over the roof of both orbits (arrow).


(c) Bilateral otitis media with mastoiditis with granulation tissue/cholesteatoma in the mastoid bone (arrow).


Sequential bone marrow karyotype and FISH studies: percentage of del(5q) and Y chromosome loss from October 2007 to March 2014 during the various phases of lenalidomide treatment.


Changes in Hb levels from October 2007 to March 2014 under various phases of lenalidomide treatment.


A 2-year-old girl with left knee pain and a medullary lytic lesion in the proximal tibial metaphysis. Antero-posterior view.


A 2-year-old girl with left knee pain and a medullary lytic lesion in the proximal tibial metaphysis. Lateral view.


Magnetic resonance imaging findings. (A) The T1-weighted image revealed the penumbra sign (white arrow).


Magnetic resonance imaging findings. (B) The fat-suppressed T2-weighted image revealed very high signal intensity of the central part of the lesion.


Magnetic resonance imaging findings. (C) The gadolinium-enhanced fat-suppressed T1-weighted image showed peripheral rim enhancement.


Histologic and immunohistological examination. (A) Histologic examination showed multinucleated giant cells and mononuclear histiocytes aggregated with eosinophils and neutrophils (200x).


Histologic and immunohistological examination. (B) Immunohistologic stains for CD1a confirmed the presence of multinucleated giant cells and mononuclear histiocytes (200x).


Intraoral swelling in relation to the left permanent lower first molar.


IOPA showing grossly carious lower first molar, resorption of mesial root and bone loss.


OPG showing presence of three supernumerary teeth along with the normal complement of teeth.


Intraoral view after excision.


Excised tissue specimen.


Serial thoracic computed tomographies (CTs) that demonstrate the lesion migration. (A) Image before corticosteroid initiation.


Serial thoracic computed tomographies (CTs) that demonstrate the lesion migration. (B) Image after the initial short-term corticosteroid treatment.


Serial thoracic computed tomographies (CTs) that demonstrate the lesion migration. (C) Image at the time of the CT-guided biopsy.


Serial thoracic computed tomographies (CTs) that demonstrate the lesion migration. (D) Fine-needle biopsy (FNB) cutoff point.


Characteristic pictures of the bone marrow biopsy. (A) Hypercellular bone marrow with panmyelosis (trilineage hyperplasia).


Characteristic pictures of the bone marrow biopsy. (B) Diversity in nuclear morphology of the megakaryocytes (multi- or monolobated forms, irregular chromatin distribution).


Characteristic pictures of the bone marrow biopsy. (C) Aggregates of immature myeloid precursors in the intertrabecular region (myeloperoxidase stain).


Characteristic pictures of the bone marrow biopsy. (D) Abnormal localization of erythroblasts (some with megaloblastic features) on the endosteum of the trabecular bone (Glycophorin C stain).


MRI image (FLAIR) revealed an increase in signal intensity of pons.


Bone marrow exam revealed macrophages with numerous Leishmania amastigotes (magnification: 400x).


Intra-oral photograph showing swelling in the left mandibular region with obliteration of buccal sulcus.


Orthopantomograph showing multiple multilocular radiolucencies in left side of body of mandible and ramus area involving coronoid and condylar process.


Coronal slice of computed tomography (CT) scan showing expansion of medial, and ,lateral border of left side of ramus with thick, and ,curved bony septa, and ,homogenous density.


Axial slice CT at level of mandible showing soft tissue mass in left side of mandible with complete destruction of buccal and lingual plate and remnant of bone within mass extending into adjacent soft tissue with loss of flat plane.


Multiple cystic swelling on the anterior chest wall.


The cells bear characteristic morphologic features of plasma cells, round or oval cells with an eccentric nucleus composed of coarsely clumped chromatin and a densely basophilic cytoplasm. Binucleate and multinucleate malignant plasma cells are seen.


Bony lesions in multiple myeloma. The skull demonstrates the typical "punched-out" lesions characteristic of multiple myeloma.


Extraoral photographs and initial radiographs. (a) Intraoral examination.


Extraoral photographs and initial radiographs. (b) Sinus tract tracing from the nostril.


Extraoral photographs and initial radiographs. (c) Radiograph of guttapercha tracing.


Extraoral photographs and initial radiographs. (d) Radiograph of calcium hydroxide hard packing medication.


Preoperative CBCT. (a) Cross-sectional view with intersection transverse line on the midline of the left maxillary central incisor.


Preoperative CBCT. (b) 3D reconstruction image indicates no labial cortical plate at the apical part of the root.


Preoperative CBCT. (c) Sagittal view image reveals an open apex of the toot hand no labial cortical plate.


Postoperative CBCT. (a) Cross-sectional view within tersection transverse line on the midline of the left maxillary central incisor.


Postoperative CBCT. (b) 3D reconstruction image shows the labial cortical plate at the apical part of the root.


Postoperative CBCT. (c) Sagittal view image reveals labial cortical plate formation and incomplete healing of the apex of the tooth.


CTV-SR (blue), CTV-HR (orange), and GTV (red) on the simulation CT. . Notes:. The CT layer of the upper edge of CTV-SR; combined CTV-SR included PS and LLN-. LLN-. And M; CTV-HR included M around GTV. LLN-. And M; CTV-HR included M around GTV. . Abbreviations: CT, computed tomography; CTV-HR, high-risk clinical target volume; CTV-SR, standard risk clinical target volume; GTV, gross tumor volume; LLN-A, anterior lateral lymph nodes; LLN-P, lateral lymph nodes; M, mesorectum; PS, presacral space.


CTV-SR (blue), CTV-HR (orange), and GTV (red) on the simulation CT. The CT layer of the upper edge (rectosigmoid) of GTV, combined CTV-SR included PS.


CTV-SR (blue), CTV-HR (orange), and GTV (red) on the simulation CT. The CT layers of mid-low.


CTV-SR (blue), CTV-HR (orange), and GTV (red) on the simulation CT. Low. Pelvic, combined CTV-SR included PS, posterior LLN-P.


CTV-SR (blue), CTV-HR (orange), and GTV (red) on the simulation CT. The CT layers of the lower edge of CTV-HR.


CTV-SR (blue), CTV-HR (orange), and GTV (red) on the simulation CT. CTV-SR ; CTV-SR and CTV-HR included M.


Inflammation of the brachial plexus shown as hyperintense areas
as pointed by arrows.


MRI findings. A; Axial T2-weighted MR image shows heterogeneous hyperintensity with a prominent high-signal spot of the solid mass in the left maxillary sinus and masticatory space.


MRI findings. B; Axial contrast-enhanced T1-weighted MR image shows strong and heterogeneous enhancement of the mass.


Histopathological findings. A; Gross pathological view demonstrates a shiny white solid mass.


Histopathological findings. B; Microscopic view with hematoxylin and eosin staining reveals dense proliferation of follicular structures made up of tumor cells resembling odontogenic epithelium. Tall columnar cells resembling ameloblastoma cells surround peripheral follicles, which contain stellate reticulum-like central areas.


Ulceration visualized on colonoscopy. Colonoscopy conducted 12 months post-HSCT showing healthier tissue in the periphery and a central area of ulceration.


Postoperative X-ray dorsal spine anteroposterior.


Lateral views showing full correction of scoliosis with implant in situ. Peroperative photograph showing posterior fixation and reconstruction using fibulae.


(a and b) Radiographs of dorsal spine anteroposterior and lateral views at 1 year followup showing maintenance of alignment; however, anterior fusion is not seen.


(c) Computed tomography scan at one year showing anterior void and fibulae had not united.


(a and b) Anteroposterior and lateral radiographs of dorsal spine at 7 months followup showing maintenance of alignment.


(c) Computed tomography scan at 7 months following anterior reconstruction showing that tricortical graft has not resorbed but no fusion at graft host bone interface.


Preoperative image showing frontal and parietal swellings.


CT image showing hyperintense lesion surrounding the skull bone.


CT image showing the herniation syndrome with gross mass effect.


CT image showing the 'Honeycomb' appearance of the involved bone.


Photograph of the involved dura.


Photograph of the involved bone showing the typical 'honeycomb' appearance.


Intraoperative photograph showing the extra-calvarial extension of the lesion.


Photograph showing the portion with intradural extension.


Post-operative CT image showing gross excision of lesion with resolution in mass effect.


Histopathological slide showing characteristic small round blue cells with prominent nucleoli.


Peripheral blood films show numerous blast-like cells with fine chromatin and high nucleus-cytoplasm (N/C) ratio along with remarkable rouleaux formation and thrombocytopenia (Wright Giemsa stain, 100x).


Bone marrow biopsy revealed hypercellular marrow for age mostly replaced by a diffuse infiltration of blasts (Hematoxylin Eosin stain, 10x).


Tongue depressed with wooden spatula revealing soft tissue mass extending from the nasopharynx and involving uvula.


Nasopharyngeal mass completely obstructing the. Right posterior choana.


Left posterior choana.


(a) Hematoxylin and eosin staining revealed atypical lymphoid cells of medium size with a round to oval shape with vesicular nuclei and irregular nuclear membrane, magnification = 400 x.


(b) The atypical lymphoid cells were positive for CD20 (brown) immunohistochemical stain, magnification = 40 x. A similar positivity pattern was seen for CD79a, CD5, and cyclin D1 (images not shown).


(c) The atypical lymphocytes were negative for CD3 immunohistochemical stain, magnification = 40 x. A similar negativity pattern for CD10 and CD23 was seen (images not shown).


(d) Ki-67 staining (brown) revealed a proliferative index of 20-30%, magnification = 40 x.


Evolution of treatment, blood requirement, and biology of the patient during the period of interest. The arrow represents 1 red blood cell pack. The plasmapheresis took place over 10 days, then the patient received 2 cycles of paclitaxel, after which she received eculizumab during 4 weeks. Finally, she was concomitantly treated with palbociclib. C, cure.


Contrast-enhanced CT of the kidneys in patient K. The left kidney examined prior to the second surgery is indicated.


Pathomorphological examination of the mass excised from the right kidney of patient K. Type I papillary RCC. Hematoxylin-eosin staining, magnification x100.


Sanger sequencing of part of MET exon 16 in patient K. The c.3328G>A (p. V1110I) mutation is indicated by the letter R.


Preoperative photograph.


(a) Preoperative contrast-enhanced computed tomography brain.


(b) Preoperative magnetic resonance imaging T2 axial.


(c) Preoperative magnetic resonance imaging saturation weighted images axial.


(d) Preoperative magnetic resonance imaging T1 postgadolinium axial.


Post first surgery computed tomography brain.


Post second surgery computed tomography brain.


Postoperative magnetic resonance imaging T1 postgadolinium.


Variation of total billirubin and hematocrit of both the twins (arrow represents the transfusion received by them).


Anti-M alloantibody titre variation in mother and twins.


Computed tomography scan showing a large adrenal tumor having fatty tissues on the right side.


The regular CT scan before and after sunitinib treatment. Radiology of pretreatment . . Notes: (A) Baseline with evidence of lung (right red arrow) and pancreas (left red arrow) metastases before starting sunitinib.


The regular CT scan before and after sunitinib treatment. Post-treatment. Findings in our patient under sunitinib treatment. (B) Evidence of decrease in tumor size on regular scan after 3 months of sunitinib treatment.


Radiograph showing bamboo spine.


Computed tomography chest showing right-sided pleural effusion and enlarged mediastinal lymph nodes.


Functional imaging of right and left paraganglioma and response to sunitinib treatment assesed by PERCIST criteria. 18F-fluoro-dihydroxyphenylalanine (18F-DOPA) positron emission tomography (PET)-computed tomography (CT) in May 2018.


Functional imaging of right and left paraganglioma and response to sunitinib treatment assesed by PERCIST criteria.


Functional imaging of right and left paraganglioma and response to sunitinib treatment assesed by PERCIST criteria. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)-computed tomography (CT) with contrast medium performed after the third cycle of therapy in June 2020.


Functional imaging of right and left paraganglioma and response to sunitinib treatment assesed by PERCIST criteria. 68Ga-DOTA-. Phe1-Tyr3-Octreotate (68Ga-DOTATOC) PET-CT in October 2018. Peak standardized uptake value corrected for lean body mass (SULpeak) trend for the hottest lesion between the two susequent 18F-FDG PET-CT (October 2020 and June 2020).


Biopsy of the nasopharyngeal mass, showing sheets of intermediate-sized blasts with round nuclei, dispersed chromatin, distinct nucleoli, and small amounts of cytoplasm. The tumor cells stained positive for myeloperoxidase and weakly for CD117. . Abbreviation: CD, cluster of differentiation; MPO, myeloperoxidase; H&E, hematoxylin and eosin.


PET-CT scan showed inflammatory changes in the nasopharynx. . Abbreviations: CT, computed tomography; PET, positron emission tomography.


Hematoxylin and eosin stained slide of left neck biopsy. A diffuse proliferation of intermediate to large mononuclear cells with round to irregular nuclei, dispersed chromatin, distinct nucleoli, and small amounts of cytoplasm, consistent with blast forms are seen. Admixed are plasma cells, small lymphocytes, and additional myeloid elements, including abundant eosinophilic forms.


Molecular diagnostics of the patient's tumor. A; Copy number assessment of chromosome 4 shows a one copy loss of the 5' end of PDGFRA.


Molecular diagnostics of the patient's tumor. B; Translocation analysis shows the discordant reads map to intron 10 of FIP1L1 and exon 12 of PDFGRA.


Molecular diagnostics of the patient's tumor. C; Metaphase FISH analysis shows one normal copy of chromosome 4, which retains all 3 FISH probes on 4q (green SCFD2 that is centromeric to FIP1L1, orange LNX that is located between FIPL1 and PDGFRA, and blue KIT that is telomeric to PDGFRA). The other copy of chromosome 4 shows an isolated deletion of LNX with retention of the flanking SCFD2 and KIT probes, indicative of a FIP1L1-PDGFRA rearrangement. Trisomy 8 is also present in these cells, as evidenced by 3 CEP 8 probe signals.


Hypointense cystic lesion in axial and coronal T1 weighted MRI.


Hyperintense cystic lesion with massive edema in axial and coronal T2 weighted MRI.


Rim enhancing lesion in axial and coronal contrast-T1 weighted MRI (Sagittal views not included due to bad quality).


Surgical view of left temporal lobe with the exposed temporal horn (yellow arrow) containing the cystic lesion at superior border (white arrow) and velvety debris along the ependymal layer.


A; Sagittal section of MRI of the brain showing destruction of the clivus by the clivus tumor.


B; Coronal section of the MRI of the brain showing destruction of the clivus by the clivus tumor.


C; Poorly differentiated squamous cell carcinoma of the neoplastic cells are arranged in groups surrounded by nonneoplastic lymphoid cell component. H&E. Magnification x200.


The pedigree of this family was compatible with autosomal dominant inheritance of hypercalcaemia. . The proband is indicated by an arrow. The phenotype (plasma calcium concentration) as well as genotype of both parents of the proband is unknown. The plasma calcium concentration of the son of the proband [III(2)] was normal and targeted
AP2S1 mutation analysis was negative. The calcium status of the baby boy of III(1) was not available and it was omitted from the pedigree.


Per-operative view showing adrenal tumor (arrow) with extensive retroperitoneal hemorrhage.


Macroscopic inspection of the resected adrenal pheochromocytoma( (10 x 7 x 2 cm).


Histological findings of the tumor. Pheochromocytoma cells located around fine vascularisation (hematoxylin-eosin, X20).


MRI of the brain. (A) T2/fluid-attenuated inversion recovery (FLAIR) coronal view shows hyperintensity in the right caudate, internal capsule, and putamen.


MRI of the brain. (B) T2/FLAIR axial view shows additional lesions involving left thalamus and lenticular nuclei.


MRI of the brain. (C) Diffusion-weighted imaging axial view shows three lesions with restricted diffusion. Arrows indicate CNS lesions.


MRI of the brain after 3 months of follow-up. T2/fluid-attenuated inversion recovery (FLAIR) coronal.


MRI of the brain after 3 months of follow-up. Axial. Views show size reduction of the pre-existing lesions in the basal ganglia, thalamus, and internal capsule.


MRI of the brain after 3 months of follow-up. (C) Diffusion-weighted imaging axial view showing no signal alteration. Arrows indicate CNS lesions.


Brain MRI of the left frontal cystic tumor with parasagittal mural nodule. Axial FLAIR image.


Brain MRI of the left frontal cystic tumor with parasagittal mural nodule. Coronal T2 image.


Chest x-ray: Right lower lobe consolidation with right-side pleural effusion.


Chest x-ray: No evidence of active lung disease.


(a) Chest CT scan-axial view.


(b) Chest CT scan-coronal view. (a&b). Chest CT scan: Moderate right pleural effusion and right lower lung Consolidation.


(b) Chest CT scan-coronal view. (a&b) Chest CT scan: No significant change in complete consolidation of the right lower lobe as compared to previous Chest CT scan and moderate right-side pleural effusion.


Plural fluid cytology: Plasmacytoid lymphocytes.


T2-weighted. Sagittal magnetic resonance images. An intradural spinal tumor existed at the level of L1 vertebral body. The tumor appeared isointense on both T1-weighted and T2-weighted MR images. Peritumoral cyst was seen at the cranial and caudal sides.


T2-weighted axial magnetic resonance images, T12-L1 intervertebral disc level.


L1 vertebral body level Peritumoral cyst was evident.


T1 image with gadorinium MR image, sagittal view.


Axial views T12-L1 intervertebral disc level.


L1 vertebral body level Homogeneously enhanced and lobulated tumor was clearly seen.


(a) Intraoperative view when opening the dura matter. A reddish tumor associated with peritumoral cysts at both cranial and caudal sides was found.


(b) The tumor arose from the film terminale.


Intraoperative indocyanine green (ICG) videoangiography showing the tortuous feeding arteries from the both poles and the draining vein along the film terminale.


Histopathological findings of the tumor (HE stain). The tumor was composed of vacuolated stromal cells and small nucleus in a rich capillary network with several enlarged vessels.


Pre-operative magnetic resonance images. Sagittal plane.


Pre-operative magnetic resonance images. Transverse plane. T2-weighted images showing a hyperintense, intramedullary mass at the level of the L3-4 intervertebral disk space (asterisk) and associated peritumoral edema cranial to the mass (arrow).


Pre-operative magnetic resonance images. Transverse plane. Post-contrast T1-weighted images showing marked, homogenous contrast enhancement of the mass.


Telangiectasias were noted on the back and trunk.


A contrast enhanced CT scan of the abdomen demonstrates showing a large right-sided perinephric fluid collection.


laparoscopic approach revealed an ileoileal intussusception, approximately 40cm from the ileoceacal valve.


a laparoscopic disintussusception approach was performed, with no signs of ischemia or perforation after the reduction of the small bowel.


FLAIR weighted image showing multiple sclerosis lesions distributed mainly periventricularly and a hyperintense lesion in the fronto-parietal region that extends to the cortex, suggestive of progressive multifocal leukoencephalopathy.


Intravenous urography showing displaced right kidney.


Computed tomography scan showing large adrenal mass.


Cut section of the excised specimen.


Histopathological slide showing myelolipoma with osseous metaplasia.


Magnified view showing myelolipoma.


Abdominal CT showing lymphadenomegaly. Perigastric.


Abdominal CT showing lymphadenomegaly. Periportal space.


Abdominal CT showing lymphadenomegaly. Mesenteric region.


Abdominal CT showing lymphadenomegaly. Hepatosplenomegaly with perfusional heterogeneity in the spleen consistent with infarction.


Intra oral picture showing buccal cortical expansion.


Panoramic radiograph showing "soap bubble" appearance of the tumor.


Pictomicrograph depicting small cords of tumor cells with peripheral ameloblast like cells and stellate reticulum like cells that exhibit squamous metaplasia at places.


Pictomicrograph depicting it as follicular ameloblastoma with desmoplasia along with areas exhibiting cystic degeneration and squamous metaplasia.


The gross specimen displays an endophytic, ulcerating mass involving the terminal ileum, ileocecal valve, and cecum.


A; Gross pathology of the resected bowel. The asterisk shows the endophytic mass at the distal ileum.


B; Tumor cells demonstrate signet-ring cell morphology with eccentrically displaced nuclei and abundant vacuolated cytoplasm. HE. X200.


Computerized tomography of the abdomen showing hyperdensity (clot) in the portal vein.


Abdominal ultrasonography revealing moderate non-occlusive thrombus within the main portal vein.


Light microscopy imaging of the renal biopsy demonstrating a small vessel vasculitis. Original magnification x400, using Haematoxylin-eosin stain.


Light microscopy imaging of the renal biopsy demonstrating a medium sized vasculitis. Original magnification x100, using Haematoxylin-eosin stain.


The bone marrow biopsy showed nodular proliferation of neoplastic lymphocytes (A, H&E x 20).


Immunohistochemistry revealed the lymphocytes positive for CD23 (B, x 20).


Flow cytometry analysis confirmed lymphocytes positive for CD20 and predominantly negative for CD38 (C).


FISH study revealed loss ofD13S319 signal, which indicated the deletion of 13q (D).


(A) Pretreatment CT imaging showed a left pelvic sidewall mass, pelvic mesenteric lymphadenopathy, and external iliac lymphadenopathy.


(B). Pretreatment PET shows hypermetabolic pelvic lesion however unable to accurately measure SUVs in this mass due to concentrated radiotracer within the involved left ureter.


(C). Pretreatment CT imaging showed associated left hydronephrosis.


(D) Post treatment PET scan after 6 cycles of induction therapy showed low level metabolic activity within the left pelvic sidewall mass, SUV max 2.1, no evidence for recurrence.


Changes in serum carcinoembryonic antigen levels. The time highlighted in gray corresponds to the period during which mFOLFOX6 + EGFR antibodies (three cycles of panitumumab and 17 cycles of cetuximab) were administered. The horizontal dotted line shows the cutoff level of serum CEA. . Abbreviations: mFOLFOX6, modified FOLFOX 6; EGFR, epidermal growth factor receptor; CEA, carcinoembryonic antigen.


The bone marrow image showed an MM bone marrow change (Wright stain).


Echocardiography showing increased ventricular mass and granular sparkling pattern of myocardium (black arrows).


ECG showed ST-T abnormality after 3 months of admission.


Oral mucosal exfoliated cells showing multiple deposits of amyloid, positive for Red Congo stain.


With yellow birefringence under polarized light.


Immunohistochemistry staining showing CD4 positivity.


Histologic section of a basal cell carcinoma with perineural invasion (Hematoxylin and Eosin, 10x).


A) Basal cell carcinoma of the right lower eyelid and lateral canthus.


B) The surgical defect after resection of the mass with frozen section control of the margins.


C) The defect was closed using a tarsoconjunctival flap and a full-thickness skin graft.


D) Final appearance after opening the flap and administration of postoperative adjuvant radiation therapy.


Surgical resection of zone II-III leiomyosarcoma. , leiomyosarcoma protruding into right atrium.


Surgical resection of zone II-III leiomyosarcoma. , en-bloc resection of IVC with whole liver.


Surgical resection of zone II-III leiomyosarcoma. , bench resection of tumor, and ,hypothermic perfusion.


Surgical resection of zone II-III leiomyosarcoma. , IVC reconstruction with prosthetic graft.


Surgical resection of zone II-III leiomyosarcoma. , hepatic veins' orifices after leiomyosarcoma resection.


Surgical resection of zone II-III leiomyosarcoma. , re-implanted liver graft.


Radiologic examination of the patient. (a) Chest X-ray showing serious interstitial and alveolar oedema.


Radiologic examination of the patient. (b and c) Chest posteroanterior shows interstitial and alveolar oedema improved.


Radiologic examination of the patient. (d) CT revealed a left suprarenal tumour of 5.8 cm x 5.7 cm in size with necrosis (white arrow).


Patient with PCC treatment by VA ECMO.


Dynamic changes in blood pressure and dosage of vasopressors in the patient. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and dosages of norepinephrine (NE), epinephrine (E), dopamine (DA), and ECMO indicated. The dramatic cyclic blood pressure fluctuation during the catheter removed periods is particularly notable.


The histological diagnosis was pheochromocytoma of the adrenal medulla. (a) The tumor cells were distributed in nests under high magnification, with Sertoli cells and vascular sinuses visible around them. The tumor cells were polygonal and bubble-like with obvious nucleoli (HE x400).


The histological diagnosis was pheochromocytoma of the adrenal medulla. (b) The expression of S-100 in the Sertoli cells (IHC x400).


The histological diagnosis was pheochromocytoma of the adrenal medulla. (c) The expression of Syn in tumor cells (IHC x400).


The histological diagnosis was pheochromocytoma of the adrenal medulla. (d) The expression of CgA in tumor cells (IHC x400).


(a) Note the absence of enamel in the upper and lower teeth and complete absence of Cuspal tips in the lower teeth due to severe attrition.


(b) Proximal caries in relation to mesial surfaces of both the upper lateral incisors.


Presence of deep periodontal pocket in relation to the distal surface of right central incisor (c) The gingiva appears moderately inflammed with bulbous interdental papillae and rolled margins. Presence of deep periodontal pocket in relation to the distal surface of left central incisor.


Orthopantomogram shows proximal caries in relation to lower first molars and initial bone loss in relation to the distal surfaces of both molars.


Timeline with relevant data from the episode of care.


Bilateral, hypodense basal ganglia necrosis in unenhanced CT (arrows); Philips Ingenuity 5 mm.


Bilateral basal ganglia necrosis with T2w hyperintense alterations 3 T Philips Ingenia,. FLAIR.


Hemoside deposits. SWI.


These changes are diffusion-disturbed (C,D). B1000 image.


These changes are diffusion-disturbed (C,D). ADC map.


Lithium concentration versus time. Continuous veno-venous haemodiafiltration session is represented with a double arrow ( ).


(A,B) T2W sagittal and dorsal, showing a large hyperintense space occupying mass in the cerebellum.


T1 post contrast sagittal, showing mild heterogeneous contrast enhancement, especially at the rim.


SWI transverse showing signal drop out centrally, consistent with hemorrhage.


Photomicrograph of medulloblastoma in a dog. Sheets of neoplastic polygonal to elongated cells with large basophilic nuclei and limited pale eosinophilic cytoplasm create the characteristic "small blue tumor" appearance. Further features include a brisk mitotic rate (arrowheads) and rare entrapped cerebellar Purkinje neurons (arrow). H&E. 40x magnification. Bar = 20 um.


MRI of the brain revealed prominent bilateral enhancing parietal-occipital lesions on FLAIR and T2 sequences and small areas of hyperintensity in the left periventricular white matter on diffusion-weighted images.


Brain magnetic resonance imaging on the second day after onset. Brain MRI showed diffusion restriction in diffusion-weighted imaging (DWI) and hyperintensity of fluid-attenuated inversion recovery (FLAIR) in the bilateral parieto-occipital lobe on the second day after onset.


Computer tomography angiography of the chest demonstrating bilateral segmental lower lobe pulmonary embolism.


Computer tomography abdomen revealing wedge-shaped defects of the spleen consistent with infarcts.


A. Bone marrow aspirate smear showing promyelocytes with ovoid to monocytoid nuclei, abundant cytoplasm with numerous pink, red or purple granules that obscure the nuclear outline. The cells contain numerous intertwining auer rods (arrows).


B. The bone marrow biopsy showing hypercellularity with aggregates of promyelocytes (x200).


C. High power image showing promyelocytes with relatively abundant cytoplasm and convoluted nuclei that are often eccentrically located (x400).


Close-up view of the superficial lesions. A; Photo at initial presentation. The lesions can be seen in the eyelids, conjunctiva and expanding into the subconjunctival space.


Close-up view of the superficial lesions. B; Four months later, the lesions were partially reduced.


Close-up view of the superficial lesions. C; Eight months later, a clear tendency toward regression can be seen.


Close-up view of the superficial lesions. D; After 1 year of treatment, the lesions were nearly absent.


Pilonidal abscess, sagittal computed tomography (CT) images on admission (A) CT scan showing soft-tissue ill-defined thickening from the lumbar spine to the sacrum, with a focal well-defined fluid collection measuring approximately 2.9 x 0.8 cm (arrow).


Time of neutrophil recovery (B) Three weeks postinduction CT sagittal images showing increase in well-defined fluid collection, now measuring 1.3 x 2.2 x 6.4 cm (marked with arrow).


(A) Magnetic resonance imaging (MRI) T2 coronal images with marked edema and enhancement of the left adductor magnus and brevis muscles, with focal areas of nonenhancement consistent with myonecrosis (arrow).


(B) MRI T1 fast-spin coronal images with progression of the edema and development of a fluid collection in the proximal medial thigh measuring 3.9 x 10.3 x 8.5 cm (marked with arrow).


Axial T2-weighted magnetic resonance image shows progressive multifocal leukoencephalopathy with a large confluent hyperintense lesion in the left occipitotemporal region.


Axial T2-weighted, fluid-attenuated inversion recovery magnetic resonance image shows progressive multifocal leukoencephalopathy with a high signal intensity lesion involving the white matter of the dorsal right frontal lobe and right frontal operculum, as well as lateral left frontal and inferior left occipitotemporal region with no mass effect.


Intraoral photograph showing diffuse edema and bluish discoloration of gingivo-alveolar mucosa over the left body region of the mandible.


Orthopantomogram showing well-defined 3x3-cm periapical radiolucency involving the roots 35, 36, and 37. Of them, 35 appeared to be endodontically treated and with a replaced crown.


CT scan showing buccal cortical expansion, along with loss of trabeculae and slight perforation of the lingual cortical plate.


Intraoperative photograph showing the defect after removal of lesion.


Photomicrograph revealing sheets of mature plasma cells along with immature and nucleolated cells permeating the bone, suggestive of plasmacytoma/myeloma.


(A) Kidney graft function and serum concentrations of lymphocyte populations before and after application of mesenchymal stem cells. Three consecutive applications of mesenchymal stem cells are marked with arrows. EGFR, estimated glomerular filtration rate; mGFR, measured glomerular filtration rate (by Cr-EDTA); conc, concentration; Treg, regulatory T cells.


(B) Cytokine concentrations after mesenchymal stem cells application (in U/mL for soluble interleukin 2 receptor and in pg/mL for other cytokines). Time frame of corticosteroid treatment is marked with arrows; Legend: TNF, tumor necrosis factor; IL, interleukin; s-IL-2-R, soluble interleukin 2 receptor; IFN, interferon.


Ultrasound abdomen reveals a large, well encapsulated, heterogeneous left suprarenal mass.


After pelvic fracture surgery (left sacroiliac joint separation and pubic fracture ) on the AP pelvic radiograph. The open reduction and internal fixation technique used in the operation. The internal fixation is a reconstructed titanium alloy plate (USA, Zimmer Inc).


Electric myofascial impactor (gun) used by the physiotherapist. The fascia guns we use are manufactured in China. It typically produces three types of vibration (low, medium and high), and its probe transmits physical vibration waves to the body's soft tissues, which are used by physiotherapists to relax and loosen the adhesion of the patient's limbs and back. It can't hit the joints, head, abdomen. Do not use for more than 10 minutes at a time to avoid soft tissue damage.


Abdominal computer tomography (CT). Arrow: haematom; horizontal view.


Computer tomography (CT) scan of the abdomen; sagittal view.


Surgical resection of the tumor. Tumor of 35 x 30 x 17 mm.


Photo of the tumor at low magnification (X50). Nodular and well limited tumor composed of sheets of eosinophilic cells with Hematoxylin Eosin and Saffron (HES) stain.


Photo of the tumor at high magnification (X200). Tumor cells are large with an abundant eosinophilic cytoplasm and round regular nuclei with small nucleoli, according with Leydig cells. Hematoxylin Eosin and Saffron (HES) stain.


Photo of the tumor at high magnification (X400). Tumors cells were diffusely stained with antibody to inhibin A(immunoperoxydase). All tumor cells present a diffuse and strong cytoplasmic staining.


Photo of the testicular biopsy at high magnification (X100). Histopathological micrograph with hematoxylin-eosin-green FCF stain. The testicular biopsy consists of tubules with hypospermatogenesis (white arrows) mixed with aplasia (black arrows).


Testicular Steroidogenesis.


H&E stain of the patient's lung adenocarcinoma specimen under 20x magnification.


H&E stain of the patient's bone marrow biopsy consistent with MPN under 40x magnification.


CD20 immunostain of the patient's small bowel biopsy consistent with DLBCL.


H&E stain of the patient's bone marrow biopsy consistent with AML-M5 under 40x magnification.


Patternless sheets of primitive appearing neoplastic cells with hyperchromatic nuclei with neuropil.


Primitive appearing neoplastic cells with hyperchromatic nuclei, scant cytoplasm, and indistinct cell borders.


Tumor cells showing positivity for immunohistochemical stain CD56.


Tumor cells showing focal positivity for immunohistochemical stain glial fibrillary acidic protein.


(a) USG showing perirenal hypoechoic collection.


(b) CECT - Renal parenchymal enhancement with perirenal and renal sinus hypodense nonenhancing collection.


(c) MRI T2W coronal section showing bilateral perirenal hyperintense collection with septae.


(a) Perirenal multicystic lesion dissected.


(b) Lap deroofing in progress.


(c) Postoperative CT scan (delayed film).


(A) The blood cell and PCM1-JAK2 fusion transcript changes in patient 1 over the course of the disease.


(B) The blood cell changes in patient 2 over the course of the disease. WBC, white blood cells; HB, hemoglobin; PLT, platelet; Eo, eosinophils.


Select chest radiograph images during the patient's hospitalization.


Medical image.


Laminectomy specimen showing mature binucleate plasma cells (plasmablasts).


Epithelial membrane antigen positive.


CD 138 positive. Multiple myeloma oncogene-1 positive suggestive of plasmacytoma.


(a) Preoperative sagittal T2-weighted magnetic resonance (MR) image showing extensive syringobulbia and syringomyelia and a small mass (arrow) in the spinal cord at C6.


Preoperative sagittal and axial gadolinium (Gd)-enhanced MR images of the cervical spine showing a small enhanced mass in the spinal cord at C6.


In the right anterior quadrant of the spinal cord.


(d) Gd-enhanced MR angiogram of the upper parts of the body showing tumor staining in the cervical spine.


(a) Three-dimensional (3D) computed tomography angiogram showing C6 and surrounding structures.


(b) 3D computer graphic image showing the anatomical relationships of the spinal tumor (purple) and feeding artery (pink), and the cervical vertebral bodies (white), trachea (yellow), esophagus (purple), common carotid artery (red), and jugular vein (blue).


(c) Planned corpectomy of C6 and simulated surgical view showing the anterior radicular artery (pink and arrow), anterior spinal artery (pink and arrowheads), tumor (purple), and drainer (blue).


Surgical microscopic images. (a) After total corpectomy of C6 and partial corpectomies of C5 and C7.


Surgical microscopic images. (b) Indocyanine green (ICG) injection showing the tumor stain (star), the anterior spinal artery, and surrounding venous drainage.


Surgical microscopic images. (c) Opening of the dura mater exposed these structures.


Surgical microscopic images. (d) ICG injection clearly showing the anterior radicular artery (arrow), anterior spinal artery (arrowheads), and the tumor (star).


Surgical microscopic images. (e) Temporary clip was applied to the feeding artery of the tumor.


Surgical microscopic images. (f) ICG injection showing reduced blood supply.


Surgical microscopic images. (g) Dissection of the tumor.


Surgical microscopic images. (h) ICG injection showing no residual tumor and the intact anterior spinal cord artery.


Follow-up MR images 1.5 years after the surgery. (a) Sagittal T2-weighted MR image showing disappearance of the tumor and collapse of the syrinx.


Follow-up MR images 1.5 years after the surgery. Sagittal.


Follow-up MR images 1.5 years after the surgery. Axial. Gd-enhanced MR images revealing total removal of the tumor.


Follow-up MR images 1.5 years after the surgery. Postoperative cervical radiographs,. Anteroposterior.


Follow-up MR images 1.5 years after the surgery. Postoperative cervical radiographs,. Lateral. Views, showing good graft bone fusion.


A large noduloulcerative lesion on the left scapular region.


Immunohistochemistry showing CD68 positivity.


Following surgical excision.


Diffuse cutaneous hyperpigmentation and sclerodactyly on the legs and hands.


Papular lesion in the right infraclavicular region.


Papular lesion with presence of red lakes.


Exophytic lesion containing vascular structures in dispersed connective stroma.


Radiographic outcome in PRF-treated permanent maxillary right central incisor:. Tooth showing incompletely developed root with wide, and ,open apex, thin dentinal walls, and ,wide root canal space with periapical radiolucency.


At third month follow-up, tooth showing slight elongation in the root with accelerated closure of the apex, and ,resolution in periapical radiolucency.


At the sixth month follow-up, tooth showed marked increase in the root length, obliteration of the root canal space, and ,excellent closure of the root apex with normal periapical anatomy.


At the 12th month follow-up, PRF-treated tooth exhibited excellent root lengthening, complete closure of the apex with normal periradicular architecture, thickened dentinal walls, and narrowing of the root canal space.


Radiographic outcome in blood clot-mediated revascularization done in permanent maxillary left central incisor:. Tooth showing incompletely formed root with wide, open apex, and ,thin root dentinal walls, wide root canal space, and ,widened periodontal ligament space.


At the sixth month follow-up, apex still found open.


At 12th month follow-up, blood clot-treated tooth exhibited continued root elongation and favorable closure of the apex with periradicular architecture and slightly thickened root dentinal walls.


Picture showing retrieval of platelet-rich fibrin gel formed after centrifugation.


Platelet-rich fibrin clot.


Imaging studies of the left lobe of the liver by. Ultrasound examination.


Computed tomography.


T1-weighted imaging (WI).


T2WI by magnetic resonance imaging.


(A) Pathological result of the biopsy from the lesion of the left lobe of the liver.


(B) Pathological result of the resected rectal cancer.


Preoperative upper lip.


Preoperative diffuse swelling of maxillary anterior gingiva.


Hematoxylin, and ,eosin stained section showing numerous plasma cell infiltrations in connective tissue stroma (x10).


Hematoxylin and eosin stained section showing numerous plasma cell infiltrations in connective tissue stroma (x40).


Immunohistochemistry stained section showing Kappa (brown) and lambda (red).


Postoperative maxillary anterior gingiva.


Schematic overview of the timing and dosing of the BV-DHAP regimen. . Notes: Dosage in cycle 1 was reduced to 75%. Cycle 2 was administered at 100% as indicated. . Abbreviations: BV-DHAP, brentuximab vedotin and cisplatin/cytarabine; d, day; iv, intravenous; po, per os; sc, subcutaneous.


Response of platelet count to therapeutic plasma exchange.


ADAMTS13 activity from initial encounter to 45 days after discharge.


SWISS-MODEL-predicted structures of ADAMST13WT
(A) and ADAMST13 p.


R193W
(B). Tryptophan (a basic amino acid with molecular weight of 204) in substitution for arginine (an aromatic amino acid, with molecular weight of 174) changed the molecular weight, polarization and folding, probably leading to accelerated protein degradation.


G-banded karyotype of the bone marrow cells showing t(9;14)(p24;q13).


Clinical picture showing a diffuse extraoral swelling of size 4.5 cm x 3.5 cm present on the right side of the face (maxilla).


Intraoral picture showing erythematous growth on the right side of the maxilla extending from 14 to 17.


Radiograph revealing ill-defined radiolucency and significant bone loss on the right side of the maxilla.


Odontogenic epithelium in follicular pattern, few of the follicles showing stellate reticulum-like cells, along with increase in cellular atypia and mitotic activity.


CK19 was found to be positive.


Post-mortem histological images of the bone marrow. A; Hypercellular intertrabecular space. H&E. X4.


Post-mortem histological images of the bone marrow. B; Cell population with large eosinophilic cytoplasm and cerebriform nucleus. H&E. X20.


Post-mortem histological images of the bone marrow. C; Positive immunohistochemical staining for CD1a marker. CD1a.


Post-mortem histological images of the bone marrow. X20. D; Electron microscopy showing "tennis-racket" cytoplasmic organelles characteristic of Birbeck granules. X40,000.


Chronic and itchy skin lesions in the groin areas and the right hip. This skin condition had been treated for psoriasis for 5 years with topical steroid.


The international decline of rheumatic fever, with incidence data from Denmark (1862-1963) and mortality data from the United States (1921-1970). Correlation: r = 0.928, r2 = 0.81. Penicillin was introduced in 1943, in the US and in Denmark. Data for Denmark extracted from Figure 1 in Steer, and data for the US extracted from Figure 4 in Massell et al. . Both graphs changed from logarithmic to a linear scale (Note, the data for mortality before 1949 has been modified to attempt to compensate for a discontinuity in the data series related to change of the ICD criteria for diagnosis, see details in Data Sheet 1 in the Supplementary Material).


The parallel decline of stuttering and rheumatic fever, after the introduction of penicillin in 1943. The blue markers show the decline of the mortality due to rheumatic fever age 5-19, in the United States. The brown diamonds show the annual prevalence of stuttering in Palo Alto schools, California, grades 1-6 (Jackson, 1967, as reprinted in Van Riper,). A polynomial trend line is fitted to the stuttering time series. The correlation is r = 0.954, r2 = 0.91, p = 6.0E-1 (Note, as mentioned in Figure 1, the data for mortality before 1949 has been modified. The correlation without the data before 1949 is r = 0.898 with p = 4.2E-07).


The parallel decline of stuttering and rheumatic fever in different continents, after the introduction of penicillin in 1943, in the US and in Denmark. The correlation is r = 0.945, r2 = 0.89, p = 1.2E-9.


Result of multiple regression analysis of the possible confounding effect of the increasing number of students in Palo Alto schools, hypothetically resulting in reduced detection rate for stuttering. The unfilled diamonds show the stuttering data adjusted according to the multiple regression model, with the possible effect of an increasing number of students on the rate of detection of stuttering students removed, resulting in a more conservative estimate of a decline of stuttering. The correlation between the mortality due to rheumatic fever, and the prevalence of stuttering, according to the multiple regression, is r = 0.92, with p = 1E-9.


Pretreatment MRI: Coronal.


Axial.


Sagittal. Postcontrast T1demonstrate a mildly enhancing upper nasal cavity mass with extending through the cribriform plates. Associated abnormal retropharyngeal lymph nodes.


MR images important for the correct differential diagnosis: ADC map (a) demonstrating mild restricted-diffusion, suggesting hypercellularity.


Axial T2 (b) at the level of the nasopharynx demonstrates enlarged retropharyngeal lymph nodes, suggesting either primary lymphoid-disease or typical nodal spread of esthesioneuroblastoma.


Four month post treatment coronal.


Sagittal. Postcontrast T1 MR images, demonstrate decreased size of the lymphoma mass in the nasal cavity, along the cribriform plates, and prepontine cistern.


A 47-year-old female with a history of painless palpable mass within the left breast. Bilateral mammography showing an ill-defined mass in the left upper outer quadrant in keeping with biopsy-proven mammary angiomatosis (white arrow).


Three years later, the same patient represented with a history of recurrent left-sided palpable breast mass. Ultrasound of the left upper outer quadrant showing an irregular hypoechoic mass correlating with the mammographic abnormality and palpable lesion (white arrows).


(a-d) Seven years before the initial symptomatic breast presentation, the patient had been admitted to the hospital with a history of nausea, dizziness, and unsteady gait. Noncontrast computer tomography.


(a-d) Seven years before the initial symptomatic breast presentation, the patient had been admitted to the hospital with a history of nausea, dizziness, and unsteady gait. T2-weighted magnetic resonance imaging. Showed a well-defined posterior fossa cystic lesion in keeping with right-sided hemangioblastoma (white arrows).


(a-d) Seven years before the initial symptomatic breast presentation, the patient had been admitted to the hospital with a history of nausea, dizziness, and unsteady gait. Pre- and postcontrast T1-weighted coronal sequences (c and d) confirm the typical appearances of a hemangioblastoma, ie, a large cystic component and a small enhancing mural nodule (short white arrows). No enhancement evident in relation to the cystic component. Associated hydrocephalus also evident (long white arrows).


Cerebral magnetic resonance imaging with fluid-attenuated inversion-recovery (FLAIR) showing high-signal intensity lesions in the periventricular white matter.


Bilateral centrum semiovale.


Right external capsule.


Which are not prominent in the anterior temporal poles.


Time and therapeutic course of anti-neutrophil cytoplasmic antibody-associated vasculitis with rapidly progressive glomerulonephritis following COVID-19 vaccination. PE, plasma exchange; P. S. , pulse steroid; ANCA, anti-neutrophil cytoplasmic antibody; Anti-MPO, anti-myeloperoxidase-O, mo. , month. Daily pulse steroid dosage: intravenous methylprednisolone 1,000 mg daily in the first course, then 500 mg daily in the following three courses.


Histopathological and immunohistochemical features of the bone marrow biopsy. (A) Proliferation of large-sized lymphoid cells with large nuclei and conspicuous nucleoli.


Histopathological and immunohistochemical features of the bone marrow biopsy. (B) Lymphoma cells are positive for CD20 (hematoxylin and eosin; magnification, x400).


Kidney biopsy (x200). . Notes: Hematoxylin and eosin staining showing interstitial infiltration with myeloid and monocytic cells. The glomeruli are morphologically normal.


Kidney biopsy (x200). . Notes: Immunohistochemical staining for CD14 is positive in the numerous mature monocytes present in interstitium and around tubuli and glomeruli. Monocytes sometimes form aggregates simulating microgranulomas.


Magnetic resonance cholangiopancreatography evaluation for possible obstructive jaundice due to the presence of elevated bilirubin on laboratory results. . Note: The radiologist reported patient's liver diffuse with decreased signal consistent with diagnosis of secondary hemochromatosis. The green circles highlight the blackened out liver in coronal.


Magnetic resonance cholangiopancreatography evaluation for possible obstructive jaundice due to the presence of elevated bilirubin on laboratory results. . Note: The radiologist reported patient's liver diffuse with decreased signal consistent with diagnosis of secondary hemochromatosis. Axial. Planes.


Prussian blue stain of patient's liver biopsy to rule out any presence of autoimmune disease or viral etiology. . Note: Extensive iron staining (blue) of hepatocytes indicates the excess deposition confirming the diagnosis of hemochromatosis.


Computed tomography; Transverse section: 6 cm defect involving the right atrium and the right inferior pulmonary vein, which appears markedly enlarged.


MRI brain. T1 noncontrast.


MRI brain. T1 postcontrast sequences demonstrate a 7.0 cmx5.0 cmx4.9 cm heterogeneously enhancing left frontal mass with T1 shortening at the posterior aspect of the lesion, suggestive of prior hemorrhage.


MRI brain. T1 postcontrast sequences also reveal a dural tail.


MRI brain. T2-weighted sequences demonstrate a partial cerebrospinal fluid cleft around the periphery of the lesion; both findings suggest that the mass is extra- axial in origin.


CT abdomen/pelvis demonstrates a hypodense hepatic lesion (arrow) concerning for metastatic disease.


(a) Histologic sections of the left frontal mass demonstrate a high-grade SFT/HPC. Note the four mitotic figures in the mid-upper right (red arrows). (H & E, 200x).


(b) Nuclei of the neoplastic cells express STAT6, indicating a fusion of the NAB2 and STAT6 genes (Diaminobenzidine, 100x).


(a) Metastatic hemangiopericytoma in liver core biopsy (H & E, 200x).


(b) Expression of STAT6 by the neoplastic cells (Diaminobenzidine, 100x).


Postoperative surveillance MRI brain (T1 postcontrast) demonstrates no evidence of residual or recurrent disease.


Serial variation of DAT, antibody titer, Hb level and management details of the patient.


PET/CT scans of the patient. (A) Baseline. The fluorodeoxyglucose (FDG) uptakes increased in multiple patchy shadows and massive consolidations of the bilateral lungs (SUVmax = 22.1), multiple partial bones (SUVmax = 19), multiple swelling lumbosacral nerve roots (SUVmax = 16), masses in the bilateral adrenal glands (SUVmax = 31.2), and a nodule (0.7 cm) between cervical rear muscles.


PET/CT scans of the patient. (B) Disease progression after first-line chemotherapy. The sizes and FDG uptakes of massive consolidations in the bilateral lungs increased with SUVmax of 31.5. FDG uptakes of other lesions decreased.


PET/CT scans of the patient. (C) The patient achieved a complete response after four cycles of sitilimab and chidamide. The SUVmax of lesions in the left and right lungs were 2.4 and 2.1, which indicated a Deauville score of 2.


Digital subtraction angiography of case 1, lateral view of the left internal carotid artery. Two stenosis are seen.


The same artery after balloon dilatation.


Ischemic lesion in the left hemisphere distributed in the watershed area in case number 3. This indicates an embolic source or compromised flow in the left internal carotid artery.


This is the stenotic lesion in the internal carotid artery in case number 3.


(A) Changes in Hb levels after treatment.


(B) Changes in SCr levels after treatment. TPE, therapeutic plasma exchange; CRRT, continuous renal replacement therapy; RBC, red blood cell; Hb, hemoglobin; SCr, serum creatinine.


(A) Diagram of the patient's de novo heterozygous c.754G>A missense variant in exon 9 of WT1 gene; nucleotide 754 in the coding region was altered from guanine to adenine, resulting in a change of amino acid 252 from aspartic to asparagine. This missense variant has been reported to be pathogenic to Denys-Drash syndrome (DDS) according to the Human Gene Mutation Database, and it was evaluated to be pathogenic to DDS according to the American College of Medical Genetics and Genomics standards and guidelines.


(B,C) Diagrams of WT1 genes of the patient's parents showing no variation. Since reverse reads were used by Sanger sequencing, the bases shown in the peak diagram are the reverse complementary sequence C>T of the altered bases.


Cytospin-processed smear of pleural fluid revealing uniformly dispersed haematolymphoid blasts intermixed with mesothelial cells (H&E x400).


(A) Colonoscopy revealed a large tumor in the descending colon consistent with mantle cell lymphoma (MCL).


(B) Colonoscopy showed partial tumor response of MCL in the descending colon after systemic chemotherapy.


(C) Four resolution clips were placed in a "target sign" fashion around MCL tumor tissue to facilitate in radiation therapy planning.


(D) Repeat colonoscopy after radiation therapy showed resolution of MCL.


Initial presentation. Anterior labial view showing enlargement of gingiva in maxillary and mandibular arches.


Orthopantomogram revealing generalized horizontal bone loss.


Histopathology study. Section showing an arrow pointed at a bizarre mitotic figure among immature tumor cells (H&E, original magnification x1000).


Histopathology study. Section showing band cells and metamyelocytes (H&E, original magnification x1000).


Intraoral view.


Panoramic radiograph demonstrating well defined unilocular radiolucent lesion in the right mandible.


Photomicrograph showing cyst lined by ameloblastic epithelium with hyperchromatic polarized basal layer.


Panoramic radiograph showing bone regeneration in the affected area during 12-month follow-up.


Blood smear of an EDTA sample showing activated lymphocytes and platelet aggregates. Patient was referred with suspected acute leukemia because lymphocytes were misinterpreted as blasts and thrombocytopenia was not recognised as EDTA-dependent pseudothrombocytopenia.


Erythematous nodules over leg.


Boggy erythematous plaque over dorsum of the hand, with sutures at site of skin biopsy in the center.


Targetoid erythematous nodule on the radial aspect of finger.


Serum IgM level before and after therapies. (A) The serum IgM level was 23.4g/L before R-CHOP regimen and 23.90g/L after 4 cycles of R-CHOP regimen.


Serum IgM level before and after therapies. (B) The serum IgM level was 23.90g/L before R-Vd regimen and 16.10g/L after 2 cycles of R-Vd regimen.


Histopathological sections of the lymph nodes (hematoxylin and eosin staining). Small atypical lymphocytes diffusely or follicle-like distributed and follicle-like structure accounted for 75% of the whole tissue. The absolute number of centroblasts was 0-5 for each high-power field. Original magnification: 50x.


Histopathological sections of the lymph nodes (hematoxylin and eosin staining). Small atypical lymphocytes diffusely or follicle-like distributed and follicle-like structure accounted for 75% of the whole tissue. The absolute number of centroblasts was 0-5 for each high-power field. Original magnification: 100x.


Histopathological sections of the lymph nodes (hematoxylin and eosin staining). Small atypical lymphocytes diffusely or follicle-like distributed and follicle-like structure accounted for 75% of the whole tissue. The absolute number of centroblasts was 0-5 for each high-power field. Original magnification: 200x.


Histopathological sections of the lymph nodes (hematoxylin and eosin staining). Small atypical lymphocytes diffusely or follicle-like distributed and follicle-like structure accounted for 75% of the whole tissue. The absolute number of centroblasts was 0-5 for each high-power field. Original magnification: 400x.


Immunohistochemical staining of the lymph nodes. The tumor cells were positive for. CD20 (original magnification: 400x).


Immunohistochemical staining of the lymph nodes. CD23 (original magnification: 400x).


Immunohistochemical staining of the lymph nodes. CD10 (original magnification: 400x).


Immunohistochemical staining of the lymph nodes. Bcl-2 (original magnification: 400x).


Immunohistochemical staining of the lymph nodes. Ki-67 (with a proliferation index approximately 5-10%; original magnification: 400x). The tumor cells were negative for CD3, CD5, and Cycline-D1 (data not shown).


Tumor cells are diffusely distributed, with beam-like structures and capsular invasion. CD56, syn and cgA expression is positive, supporting the diagnosis of pheochromocytoma.


Chest X-ray showing pneumopericardium.


Contrast enhanced chest computed tomography (CT) scan of patient after pericardial catheter and right sided chest tube insertion. Pneumopericardium, right sided pneumothorax as well as bilateral mild pleural effusion and collapse consolidation are evident. A: Axial view.


Contrast enhanced chest computed tomography (CT) scan of patient after pericardial catheter and right sided chest tube insertion. Pneumopericardium, right sided pneumothorax as well as bilateral mild pleural effusion and collapse consolidation are evident. B: Parasagittal view.


Magnetic resonance image demonstrating left temporal lobe enhancing lesion. T2-weighted image postgadolinium showing a peripherally enhancing mass with mass with edema producing mild ventricular compression.


Brain lesion demonstrating lambda light chain immunofluorescence. Crystals show lambda but not kappa immunoflourescence. (Original magnification x600).


Electron microscopy. Histiocytes show intracellular rhomboid and needle-like inclusions. (Original magnification x10,000).


Triglyceride and alanine transaminase (ALT) trends during treatment with L-asparaginase and following infusion of SMOFlipid.


Pathogen identification from cerebrospinal fluid sample using next-generation sequencing method. (A) The number of sequencing reads identified corresponding to Human polyomavirus 2 [also known as JC virus ] was 34; with genome coverage 35.1825.


Pathogen identification from cerebrospinal fluid sample using next-generation sequencing method. (B) Reads distribution of total DNA sequence in the CSF sample without human host.


Maximum likelihood phylogenetic tree of Human polyomavirus. Human polyomavirus 2 AB103411 (in red) was the most similar strain in the cerebrospinal fluid of the patient.


Preoperative photograph showing periodontal condition after orthodontic treatment.


Preoperative orthopantomograph showing moderate-to-severe bone loss.


Preoperative full mouth intraoral periapical radiographs.


Postoperative photograph showing periodontal stability.


Postoperative orthopantomograph.


Postoperative photograph comparing before and after placing Valplast gingival prosthesis in patient's mouth.


Heterogeneous enlargement of the musculature of the anterior compartment of the right thigh consistent with hematoma (shown by red arrow).


Appearance of the lesion: reddish, ulcerated, approximately 3 cm in diameter.


Immunohistochemical staining of the lesion: CD4+.


Position of the patient's eyes in all the gazes at the time of presentation showing significantly restricted ocular movement in upgaze and mild restriction in downgaze.


MRI scan of the brain showing tiny infarct (white arrow) in the left paramedian rostral upper midbrain at the level of the red nucleus;. Axial diffusion weighted image showing restricted diffusion in the T2 hyperintensity.


Axial T2 fat saturated image showing T2 hyperintense focus.


Brown folliculocentric papules over the trunk and upper limbs.


Prominent papules over the posterior arm.


Multiple patchy lesions on an axial FLAIR image located in the subcortical white matter affecting also the internal capsule on the left side.


A; Routine HE-saffron section with enlarged abnormal oligodendroglial cell nuclei (arrow) and gliosis (arrowheads indicate gemistocytic astrocytes).


X40. B; Massive gliosis with gemistocytic astrocytes, some with irregular nuclei. X40.


Morphologic and immunohistochemical evaluation of diagnostic bone marrow aspirate and core biopsy. Diagnostic bone marrow aspirate. Wright-Giemsa, 600x).


Morphologic and immunohistochemical evaluation of diagnostic bone marrow aspirate and core biopsy. Biopsy. H & e, 200x) showing myeloid elements at all stages of maturation. The aspirate shows that blasts are not markedly increased and cells with cytology consistent with lymphoblasts are not readily apparent. Eosinophils (green arrows), basophils (arrowhead) and dwarf megakaryocytes (black arrows) are identified.


Morphologic and immunohistochemical evaluation of diagnostic bone marrow aspirate and core biopsy. Immunohistochemical staining of the bone marrow biopsy (100x) shows an expansion of CD34(subset) + TDT+ blasts (d and e, respectively) that form clusters.


Morphologic and immunohistochemical evaluation of diagnostic bone marrow aspirate and core biopsy. An expansion of CD3+ T-cells.


Morphologic and immunohistochemical evaluation of diagnostic bone marrow aspirate and core biopsy. Without an expansion of CD19+ B-cells. Is seen. In panel h, double staining of the biopsy (400x) shows that MECOM expressing cells (brown nuclear stain) are distinct from CD3+ T-cells (red membranous stain).


A; Facial skin xerosis.


B; Large rhomboidal scales covering most of the body.


C; Dry skin with rhomboidal scales on the lower extremities.


D; Plantar hyperkeratosis.


A; Hyperorthokeratosis, absence of granular layer and reduced rete-papilla pattern (HE, x40).


B; Osseous HP.


UHAg and itraconazole levels over time.


Trend of hemoglobin (Hb; dotted black line) and lactate dehydrogenase (LDH; dashed-dotted black line) levels along the patient's clinical journey. ULN, upper limit of normal; HU, hydroxyurea; ASA, acetylsalicylic acid; LMWH, low-molecular weight heparin; ET, essential thrombocythemia; PNH, paroxysmal nocturnal hemoglobinuria. Red drops represent red blood cell transfusions.


The intraoperative view showing tumor arising from the terminal ileum.


Resected part of the ileum showing friable mass.


(a) The cut surface of the specimen revealing central white mass with surrounding hemorrhage.


(b) Microscopic examination (x100) showing tumor cells scattered in subserosal aspect.


(c) Immunohistochemical staining showing tumor cells are positive for leukocyte common antigen.


(d) Immunohistochemical staining showing tumor cells are positive for S100.


Changes in WBC and ANC over 1 month of follow-up.


Bone marrow cytology (Rayleigh staining, x1,000) revealed a granulosis disorder. Red arrow, promyelocytes; blue arrow, promyelocytes.


Plain radiography of pelvis at the first week of local pain showed flake bone destruction in right femoral trochanter.


Histopathology of the incisional medical canthal biopsy specimen from the patient's right eye. A Hematoxylin-eosin staining of lymphoid follicles composed of small cells with mitotic figures and tingible body macrophages. (x 100 magnification) (b) Dense CD20 staining of B cells.


Histopathology of the incisional medical canthal biopsy specimen from the patient's right eye. A Hematoxylin-eosin staining of lymphoid follicles composed of small cells with mitotic figures and tingible body macrophages. (x 100 magnification) (c) CD3 staining of T cells within the follicles and in the interfollicular zones. (x 100 magnification).


Slow background with sharp-slow discharge in the right frontal lobe every second.


Typical paroxysmal sharp wave complexes on electroencephalography.


Bone marrow biopsy on day 16. (A) Gomori (x200) staining of the bone
marrow biopsy specimen. Bone marrow fibrosis was classified as MF-1.


Bone marrow biopsy on day 16. (B) Wright (x200) staining of a bone marrow smear. Increasing numbers
of megakaryocytes with slight dysplasia and plasma cells were observed. These are
characteristic findings of TAFRO syndrome.


Summary of the sleep study at first polysomnographic investigation. The hypnogram shows a dramatic reduction in total sleep time and complete loss of deep non-REM and REM sleep stages.


The hypnogram obtained at the second polysomnographic investigation reveals major recovery in sleep organization, with an increased total sleep time and re-acquisition of sleep stages.


(A) Chest x-ray obtained Day +42 demonstrates diffuse airspace disease bilaterally with more focal areas of consolidation in the left lung.


(B, C) Thin-section computed tomography (CT) obtained Day +49 (from 2nd transplant) demonstrate diffuse ground-glass opacification involving all 5 lobes.


Pulmonary wedge biopsy, Day +55. (A) Patchy consolidation, 2x. (A-C). Hematoxylin and eosin stain, magnifications using Leica Biosystems Aperio ImageScope.


Pulmonary wedge biopsy, Day +55. (B) Organizing pneumonia with fibroblastic proliferation in terminal airways and numerous macrophages occupying airspaces, 10x. (A-C). Hematoxylin and eosin stain, magnifications using Leica Biosystems Aperio ImageScope.


Pulmonary wedge biopsy, Day +55. (C) Pulmonary arterial thrombus with alternating bands of fibrin and platelets (lines of Zahn), 4x. (A-C). Hematoxylin and eosin stain, magnifications using Leica Biosystems Aperio ImageScope.


Timeline of events for ICU admission.


Macroscopic findings. The specimen showed a long ulcerative mass with a diameter of 18 mm, a moderately differentiated adenocarcinoma of the colon which invaded the muscularis propria and serosa from the submucosa.


CT image with adjusted plane showing a double duct sign.


A dilated common bile duct.


Immunohistochemical staining of the ampullary tumor, with benign tissue on the left border of each image. Positive staining for CK-19.


Immunohistochemical staining of the ampullary tumor, with benign tissue on the left border of each image. , CK-20.


Immunohistochemical staining of the ampullary tumor, with benign tissue on the left border of each image. , MUC-1.


Immunohistochemical staining of the ampullary tumor, with benign tissue on the left border of each image. , MUC-2.


Immunohistochemical staining of the ampullary tumor, with benign tissue on the left border of each image. , CDX-2.


Immunohistochemical staining of the ampullary tumor, with benign tissue on the left border of each image. , DPC-4.


Clinical image (a) extraoral swelling.


(b) intraoral swelling.


Preoperative.


Orthopantomogram.


Computed tomography - mandible (labial expansion).


Computed tomography - mandible lingual perforation. Computed tomography - lateral view of the Mandible.


Medical image.


Curetting the lesion.


Removed mandible.


Placing the mesh. Mesh carrying the SyboGrafts.


Intraoperative procedure. Syringes with stromal vascular fraction.


Dental pulp stem cell. Placing stromal vascular fraction and dental pulp stem cell in SyboGraft.


(c) Stromal vascular fraction mixed with granules.


(d) Placing mixed granules over lingual cortex.


Postoperative.


Orthopantomogram at 10th month.


Computed tomography mandible at 10th month AP view. Mandible lateral view.


Microscopic view of the bone marrow aspirate. . Notes: The upper picture shows a severe dysgranulopoiesis, characterized by a maturation stop after meta-/myelocyte stage, before starting filgrastim. The lower picture shows a normal bone marrow of our patient 2 weeks after terminating filgrastim.


ANC (cells/microL) of the patient (the arrows symbolize the start and the terminating of filgrastim) over several months. . Abbreviation: ANC, absolute neutrophil count.