Evolution of peripheral lymphocytes populations. Immunomodulatory effect of rituximab on cellular compartment. Pleiotropic influence of low (150 mg/m2) rituximab dose. Data expressed as absolute numbers per mul. The cell counts were analyzed during LIP exacerbation - multiorgan lymphoproliferative disease development. Typical low level of invariant natural killer T (NKT), natural killer (NK), and regulatory T cells (Treg) was observed. After rituximab therapy abnormal innate immunity - absolute number of NK and NKT cells increased, but gradual decrease of FoxP3+ regulatory T cells was observed with increase activated CD38+T cells (not shown). Leukocyte counts analyses were done by the Sysmex Automated Hematology System. Flow cytometry was performed using a FACS Calibur flow cytometer (Becton Dickinson) and a count of lymphocyte subset was calculated by the frequency multiply the lymphocyte counts.


Scleromyxedema: nodular lesions on the face.


Papular mucinosis on the neck.


Complete regression of nodular lesions on the face.


Bone marrow aspirate smear (from bone marrow biopsy) stained with May-Grunwald Giemsa showing amastigote forms of Leishmania spp.


Viral load and CD4+ T-cells count evolution following cART initiation and VL diagnosis. TRIP = travel in Greece; H = date of hospitalization; (c)ART = (combined) anti-retroviral therapy; BMB = bone marrow biopsy (VL diagnosis); M1 = first month after cART initiation; M3 = third month after cART initiation; M6 = sixth month after cART initiation; LAmB = intravenous liposomal amphotericin B administrations.


Dynamic trends in the lymphocyte subsets and cytokines in peripheral blood among patients within a household cluster with COVID-19 during 69 days of follow-up. Trends of. Lymphocyte subsets.


Dynamic trends in the lymphocyte subsets and cytokines in peripheral blood among patients within a household cluster with COVID-19 during 69 days of follow-up. B lymphocytes.


Dynamic trends in the lymphocyte subsets and cytokines in peripheral blood among patients within a household cluster with COVID-19 during 69 days of follow-up. CD8+ T lymphocytes.


Dynamic trends in the lymphocyte subsets and cytokines in peripheral blood among patients within a household cluster with COVID-19 during 69 days of follow-up. CD4+ T lymphocytes.


Dynamic trends in the lymphocyte subsets and cytokines in peripheral blood among patients within a household cluster with COVID-19 during 69 days of follow-up. Level of IL-6 in peripheral blood as detected by flow cytometry.


Dynamic trends in the lymphocyte subsets and cytokines in peripheral blood among patients within a household cluster with COVID-19 during 69 days of follow-up. Level of Il-10 in peripheral blood as detected by flow cytometry.


Massive accumulation of 18F-fluorodeoxyglucose into the abdominal cavity in positron emission tomography. (A) Moderate ascites and wall thickening of the jejunum and ileum were seen in contrast-enhanced computed tomography.


Massive accumulation of 18F-fluorodeoxyglucose into the abdominal cavity in positron emission tomography. (B) Massive accumulation of 18F-fluorodeoxyglucose was observed into the peritoneum and small bowel wall.


Massive accumulation of 18F-fluorodeoxyglucose into the abdominal cavity in positron emission tomography. (C) An endoscopic image of a jejunum tumor detected by double balloon-assisted enteroscopy. A whitish elevated tumor was seen in the proximal jejunum.


Time course after chemoradiotherapy. CRP, C-reactive protein (mg/dL); RBC, red blood cell transfusion; BPT, blood platelet transfusion.


The presurgical magnetic resonance (MR) image depicting an enhanced solid haemangioblastoma in the cerebellopontine angle (a).


Postsurgical MR image depicting the resection of the tumour (b).


Right vertebral artery angiogram exhibiting a hypervascular tumour near the superior cerebellar artery (c and d).


The presurgical magnetic resonance (MR) image demonstrating the enhanced solid haemangioblastoma in the cerebellum (a).


The postsurgical MR image demonstrating the resection of the tumour (b).


A Three-dimensional computed tomography angiogram during the late phase, exhibiting a draining vein (open arrowhead) flowing into the petrosal vein on the ventral side of the tumour (c).


Left vertebral artery angiogram exhibiting a hypervascular tumour near the anterior inferior cerebellar artery and the posterior inferior cerebellar artery (d and e).


Computed tomography (CT) images. (A) Pre-contrast CT revealing a large, solitary, well-defined mass in the spleen, with variable areas of necrosis and cystic degeneration.


Computed tomography (CT) images. Contrast-enhanced CT revealing the progressively-enhanced cystic wall, internal septa and solid portion during the. Hepatic arterial.


Computed tomography (CT) images. Portal venous.


Computed tomography (CT) images. Hepatic parenchymal phases. The areas of necrosis and cystic degeneration were non-enhancing.


Bone marrow aspirate showing trilineage hematopoiesis and mild dysplasia in the erythroid series, (May-Grunwald-Giemsa, x400).


Changes in CT in the ESCC. . Notes: (A and D) the well-circumscribed mass in right pleura (yellow arrows) and thickened esophageal wall (red arrow) prior to treatment, respectively.


Changes in CT in the ESCC. (B and E) Reduction in the lesions for the esophageal wall (red arrow) and stabilization of the lesion for the right pleura (yellow arrows) after two cycles of TP chemotherapy.


Changes in CT in the ESCC. (C and F) Esophageal wall (red arrow) thickness decrease and pleural lesion (yellow arrows) size stability after four cycles of TP chemotherapy. . Abbreviations: CT, computed tomography; ESCC, esophageal squamous cell carcinoma; TP, cisplatin-docetaxel.


Variations in CT in the ESCC 1 month after finishing all the treatments. . Note: (A and B) The stabilization of the right pleural mass (yellow arrows) and decrease of the thickened esophageal wall (red arrow) after the treatment, respectively. . Abbreviations: CT, computed tomography; ESCC, esophageal squamous cell carcinoma.


T2W/TSE sagittal MRI image 1 month after the completion of all the treatments, showing no considerable change in the size of the right pleural lesion (yellow arrow). . Abbreviations: MRI, magnetic resonance imaging; T2W/TSE, T2 weighted/turbo spin echo.


Skin lesions reflecting initial outcome after lenalidomide/celecoxib. . Notes: (A) Before treatment.


Skin lesions reflecting initial outcome after lenalidomide/celecoxib. (B) After 1 week of treatment.


Skin lesions reflecting initial outcome after lenalidomide/celecoxib. (C) After 3 weeks of treatment.


Skin lesions reflecting initial outcome after lenalidomide/celecoxib. (D) After six courses of azacitidine.


PET/CT evolution of cutaneous, nodal, hepatic, and splenic involvement. . Notes: (A) At diagnosis (black arrows pointing to skin, nodal, hepatic, and splenic involvement).


PET/CT evolution of cutaneous, nodal, hepatic, and splenic involvement. (B) After six courses of azacitidine showing metabolic complete response. . Abbreviation: PET/CT, positron emission tomography-computed tomography.


High magnification photomicrograph of the tumor showing lambda light chain positivity. (CD138 x400).


Clinical monitoring after infusion of piggyBac-generated CAR19-T cells. (A) Trends of Interleukin(IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor alpha (TNFalpha) and interferon (INF) during 28 days after infusion.


Clinical monitoring after infusion of piggyBac-generated CAR19-T cells. (B) Trend of C-reactive protein (CRP) was associated with temperature (T) rising during 28 days after infusion.


Clinical monitoring after infusion of piggyBac-generated CAR19-T cells. (C) CAR19 copies in peripheral blood were measured by quantitative polymerase chain reaction.


Clinical monitoring after infusion of piggyBac-generated CAR19-T cells. (D, E) The peak values of ferritin and lactate dehydrogenase (LHD) after infusion were later than temperature.


Clinical monitoring after infusion of piggyBac-generated CAR19-T cells. (F) Changes of white blood cells (WBC), neutrophils (NEC), platelet (PLT) and hemoglobin (Hb) during 28 days after infusion.


The clinical course and treatments. . Abbreviations: mPSL, methylprednisolone; PSL, prednisolone; CsA, cyclosporine-A; IVCY, intravenous cyclophosphamide; RTX, rituximab; MMF, mycophenolate mofetil; HLH, hemophagocytic lymphohistiocytosis; IL-6, interleukin-6; CSF, cerebrospinal fluid.


Changes in brain magnetic resonance imaging (FLAIR images). . Notes: (A) At the time of the PML onset.


Changes in brain magnetic resonance imaging (FLAIR images). (B) A month and half after PML onset before starting treatment by mefloquine and mirtazapine.


Changes in brain magnetic resonance imaging (FLAIR images). (C) Two months after the start of treatment by mefloquine and mirtazapine.


Changes in brain magnetic resonance imaging (FLAIR images). (D) Eight months after the onset of PML and 6 months after the start of treatment by mefloquine and mirtazapine. . Abbreviations: FLAIR, fluid-attenuated inversion recovery; PML, progressive multifocal leukoencephalopathy.


Intraoperative findings at secondary laparoscopic exploration surgery. . Notes:. A 3-cm diameter bleeding tumor nodule was observed on the anterior abdominal wall.


Intraoperative findings at secondary laparoscopic exploration surgery. Multiple grayish white tumor nodules on the liver surface.


Pathology revealed that the metastatic tumor of the liver surface was SMs (sarcoma) derived from YST. . Notes:. Variably sized tumor cells with severe nuclear atypia, and ,edematous stroma with multifocal hemorrhage (H&E, 100x).


Pathology revealed that the metastatic tumor of the liver surface was SMs (sarcoma) derived from YST. Scattered pleomorphic tumor giant cells (H&E, 400x).


Pathology revealed that the metastatic tumor of the liver surface was SMs (sarcoma) derived from YST. Focal positivity for AE1/AE3 immunostaining in tumor cells, AE1/AE3 immunostaining was positive in YSTs, and ,some sarcomatous tumors (IHC staining, 200x).


Pathology revealed that the metastatic tumor of the liver surface was SMs (sarcoma) derived from YST. Immunonegativity for GPC3, and ,SALL4 in tumor cells.


Pathology revealed that the metastatic tumor of the liver surface was SMs (sarcoma) derived from YST. Ki-67-positive expression found in approximately 10% of tumor cells (IHC staining, 400x). . Abbreviations: IHC, immunohistochemistry; SMs, somatic-type malignancies; YST, yolk sac tumor.


Pathology revealed that the vaginal tumor was SMs (sarcoma) derived from YST. . Notes:. Fusiform tumor cells with moderate to severe nuclear atypia (H&E, 400x).


Pathology revealed that the vaginal tumor was SMs (sarcoma) derived from YST. Immunonegativity for AE1/AE3, GPC3, and SALL4 in tumor cells (IHC staining, 400x). . Abbreviations: IHC, immunohistochemistry; SMs, somatic-type malignancies; YST, yolk sac tumor.


Histology revealed pure gonadal dysgenesis in the right gonad. . Notes:. The gonad is entirely composed of fibrous tissue, and ,devoid of germ cells (H&E, 200x).


Histology revealed pure gonadal dysgenesis in the right gonad. Immunonegativity for OCT3/4 confirming the absence of germ cells (IHC staining, 200x). . Abbreviation: IHC, immunohistochemistry.


Scattergram of normal and T-ALL pleural fluid. . Note: Scattergram of. Normal.


Scattergram of normal and T-ALL pleural fluid. T-ALL pleural fluid. . Abbreviations: T-ALL, T-lineage acute lymphoblastic leukemia; DIFF, differentiated by flow cytometry; SFL, side fluorescence; SSC, side scatter cells.


Digital image of bone marrow aspirate.


Enhanced abdominal CT taken on day 14. Part of the intestine was dilated and there was gas and fluid accumulation, and the gas-liquid level was visible.


Clinical course of the patient.


The role of head MRI in the evaluation of therapy response. . Notes: (A) T2W image shows left temporal bone involvement of LCH (white arrow).


The role of head MRI in the evaluation of therapy response. (B) This lesion shows inhomogenous diffusion restriction (black arrow) on the diffusion-weighted image.


The role of head MRI in the evaluation of therapy response. (C and D) Normal appearance of the left temporal area after the initial chemotherapy on T2W and diffusion-weighted images.


The role of head MRI in the evaluation of therapy response. (E and F) Signal abnormality in the left temporal area on the T2W (white arrow) and diffusion-weighted (black arrow) images. . Abbreviations: LCH, Langerhans cell histiocytosis; MRI, magnetic resonance imaging.


Skull lesion in LCH. . Notes: (A) Hematoxylin-eosin stain. Majority of the cells have coffee bean-shaped nuclei with open chromatin pattern and nuclear membrane grooves.


Skull lesion in LCH. (B) Strongly positive CD1a immune reaction, which is specific for LCH. . Abbreviation: LCH, Langerhans cell histiocytosis.


Massive bone marrow infiltration with ECD (original magnification). . Notes: (A) Hematoxylin-eosin stain. The marrow spaces are extensively engaged by foamy macrophages.


Massive bone marrow infiltration with ECD (original magnification). (B) S100 immune reaction. The immune phenotype of macrophages is consistent with the phenotype of the conventional tissue histiocytes (CD68 positive, S100 negative). S100 is a highly sensitive but a nonspecific marker of Langerhans cells, therefore a good marker for screening Langerhans cells, or exclude Langerhans cell origin of a tumorous proliferation. . Abbreviation: ECD, Erdheim-Chester disease.


Coronal T2W image of the spine shows very low signal intensity of the bone marrow that is specific for ECD. . Abbreviation: ECD, Erdheim-Chester disease.


(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the bone window showing an osteolytic lesion with expansion and a periosteal reaction with the appearance of sunrays around the periphery (arrows).


(B) Sagittal reconstructed CT image of the sternum showing the lesion involving the manubrium and almost all the body of the sternum. The lesion is slightly expansile and the cortex is partially destroyed.


(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the soft tissue window showing that the bone marrow of the sternum has been substituted by homogeneous soft tissue.


(B) Axial contrast-enhanced CT image of the manubrium sterni showing marked homogeneous enhancement of the tumor.


(A) T1-weighted sagital image (repetition time/echo time, 590/21 msec) of the sternum showing an area of low signal intensity in the manubrium and body of the sternum.


(B) Short-tau inversion recovery T2-weighted sagittal image (repetition time/echo time, 4150/106 msec) of the sternum showing an area of high intensity in the same region; the soft-tissue mass is clearly demonstrated.


(A) Histopathological examination (hematoxylin and eosin stain; original magnification, x200) demonstrating proliferation of round cells with abundant cytoplasm and eccentric nuclei with coarse chromatin, indicating a plasmacytoma.


(B) Immunohistochemical analysis revealing positive cluster of differentiation 38 staining on the cell membrane (arrow), which is characteristic of a plasmacytoma (original magnification, x200).


Changes in platelet level before and after development of acute thrombocytopenia.


Cytology of splenic fine needle aspiration at initial diagnosis showing occasional LGL.


Cytology of bone marrow aspiration at initial diagnosis, showing LGL in a significant proportion of lymphocytes.


Cytomorphology of bone marrow aspirates C depict an overview of the slide. (A,D) Show a hypoplastic bone marrow after stem cell transplantation with up to 10% myeloblasts (marked by an arrow) resembling early relapse after allo-HSCT. Leukemic blasts display a basophilic cytoplasm frequently containing vacuoles.


(B,E) (after one cycle of AZA) demonstrate a hypercellular marrow with ~50% of the previously described leukemic blasts (progressive disease).


(C,F) (after two cycles of APA) show a normocellular marrow with an increased and left-shifted erythropoiesis, differentiated neutrophils and no evidence of an increased percentage of myeloblasts resembling complete remission.


F show the cells at greater magnification; objective 63x). (A,D) Show a hypoplastic bone marrow after stem cell transplantation with up to 10% myeloblasts (marked by an arrow) resembling early relapse after allo-HSCT. Leukemic blasts display a basophilic cytoplasm frequently containing vacuoles.


Pedigree of kindred. On left axis, generations are labeled with Roman numerals I-V. Individual members of the family are labeled with italicized Arabic numerals. Family members related only by marriage are not numbered. Detailed family history was obtained from subject II-2, the maternal great-grandmother of the proband V-1. Subject II-2 postulates that the FAS variant stems from her father's side of the family (I-1) because his sister (not depicted) died of leukemia at age 17.


Changes in the laboratory results of the patient with acute radiation syndrome.


Histological section with haematoxylin and eosin staining, magnification, x200. Primarily round and spindle cells, were identified to contain eccentric nuclei and deeply eosinophilic cytoplasm.


Whole abdomen CT images show abdominal mass prior to treatment.


After 2 cycles of treatment.


After 4 cycles of treatment.


After the whole treatment (8 cycles).


45-dayold infant presented with splenohepatomegaly, which was subsequently diagnosed as malignant infantile osteopetrosis. X-ray of the skeleton shows (solid arrow) bone in bone appearance in the femur, tibia, humerus, radius, ulna, and iliac bones.


Preoperative CT showed fourth ventricular hemorrhage and a hyperdense mass in the cisterna magna.


Postoperative gadolinium-enhanced MRI showed no residual tumor.


(a and b) Sagittal T2-weighted images showing L5, S1 level anterior epidural hypointense lobulated mass lesion attached to the posterior surface of the vertebral body with severe canal stenosis.


(c and d) Axial T2-weighted images showing bi-lobulated lesion protruding from the vertebral body with near total canal stenosis.


Purpuric tinea corporis in patient 2 with acute adult T-cell leukemia/ lymphoma.


Wet purpura in patient 2 with acute ATL.


Verrucous papules in patient 3 with acute ATL.


Hypopigmented macules in patient 5 with smoldering ATL.


Whole body CT shows an enlarged mesenteric mass measuring 5.8x6.9x5.7 cm.


Resection of the frontal/parietal/temporal mass. Post-operative MRI contrasted T1 and T2 scans showed resection of the meningiomas in the left frontal/parietal/temporal convexity with expected post-operative changes (red arrows in A,C, not shown in B). The occipital lobe mass was visible from the sagittal view (white arrow in A).


Latest imaging. Her most recent MRIs (16 months after her last surgery) show multiple enhancing extra-axial masses, stable compared to her immediate post-operative MRIs. Here is a stable 1.8 cm (superior-inferior) meningioma arising from the left posterior falx, adjacent to the prior resection cavity (red arrows in A-C). No recurrence observed.


MRI of the spine at the level of L4/L5. Transverse T1 W.


MRI of the spine at the level of L4/L5. T1 W post contrast. Are shown. On the post contrast image there is dense, homogenous enhancement of the abnormal meninges (arrow) and, due to the severe meningeal thickening, there is circumferential compression of the spinal cord.


Magnetic resonance imaging (MRI) study at the level of L3 on a T2W sequence, transverse view. Note the enlarged right lumbar aortic lymph node (arrow), which was later sampled and cytology found to be consistent with a large granular lymphocyte lymphoma.


Fine-needle aspirates from a lymph node of a dog with a large granular lymphocyte lymphoma. Monomorphic population of large lymphoid cells, some of which contain variable numbers of fine azurophilic intracytoplasmic granules (black arrows). Wright Giemsa, 100X.


Magnetic resonance imaging scan, coronal section, T2 image, showing enlargement of all extraocular muscles in the left orbit.


Orbital CT, axial view shows an infiltrative lesion, located in the left lacrimal gland.


Consecutive ultrasounds of the left eye - superior transversal view (left column) and lateral transversal view (right column) - documenting progressive resolution of the lacrimal gland lesion after radiation therapy treatment was performed in November 2012.


Sagittal view, CT scan showing hyperdense images of a reduction in the anteroposterior diameter of the dorsal spinal canal.


Axial CT scan at the level of the T-6 neural foramen demonstrating significant posteromedial compression.


Magnetic resonance imaging. T2.


Medical image.


T1 gadolinium enhanced.


Temporal changes on PET-CT images. (a) Abnormal accumulation of fluorodeoxyglucose in the thickened walls
of the small intestine (SUVmax 12.33) and in multiple lymphadenopathy (SUVmax 7.53)
before the laparoscopic biopsy.


Temporal changes on PET-CT images. (b) No abnormal accumulation of
fluorodeoxyglucose in the entire body three months later.


Temporal changes on PET-CT images. (c) No
abnormal accumulation of fluorodeoxyglucose in the entire body, demonstrating that he
remained in complete metabolic remission three years later.


The figure shows ulcerated skin nodule on the chest wall of case 1. The other two patients also had similar skin lesions.


Multiple blasts (arrows) admixed with erythroid precursor cells (arrow heads) (bone marrow imprint, Wright-Giemsa stain, x1000). Insert shows a blast in the concurrent peripheral blood (Wright-Giemsa stain, original magnification: x1000). The blasts are medium-sized cells with irregular nuclei and scant cytoplasms which cannot be morphologically recognized as neoplastic dendritic cells. These images are related to case 1.


Blast cells are separated from the epidermis by a well-defined Grenz zone (double-arrow) (upper left, H&E, x200).


Monomorphic medium-sized blast cells with irregular nuclei (upper right, H&E, x400).


Positive membranous CD56 immunostaining (lower left, x200).


Positive cytoplasmic CD123 immunostaining (lower right, x200)Since CD123 is a specific marker for plasmacytoid dendritic cells, this positive result is a key finding without which an accurate diagnosis cannot be made. These images are related to case 2.


The proband's brain magnetic resonance imaging (MRI) obtained at 18 years old. Axial T1/T2-weighted images [Panels.


The proband's brain magnetic resonance imaging (MRI) obtained at 18 years old. , respectively.


The proband's brain magnetic resonance imaging (MRI) obtained at 18 years old. Contrast-enhancement T1-weighted image. Of the brain were obtained when the proband appeared with the first seizures. An apparent large lesion was seen in the right putamen, and a relatively small lesion was seen in the left putamen.


CT lung scan showing the extensive consolidation (57 x 61 mm) at the lower lobe of the left lung associated with pleural effusion.


CT lung scan showing the slight increment of the left lung consolidation (53 x 77 mm) appearing as an area of pulmonary opacity surrounded by normal parenchyma.


Illustration shows the microscopic examination of Lichtheimia corymbifera.


Bone marrow smear findings for case 1. Red blood cells are ingested by a macrophage (May-Giemsa staining, x400 magnification).


Tick biting the left popliteal fossa in case 1. The patient had red flares around the bite site.


Bone marrow smear findings for case 2. Platelets are ingested by a macrophage (May-Giemsa staining, x400 magnification).


SFTS viral genome analysis by RT-PCR for case 2. Primer sets were prepared for the Japanese congenital SFTS virus. To increase detection sensitivity, two primer sets for different target areas were used. Lane 1 represents a frozen serum specimen, lane 2 contains a negative control, and lane 3 contains a positive control.


The pathological images of primary breast cancer and the colonic mass. . Notes: (A) Mastectomy specimen obtained in 2001, showing lobular infiltrating carcinoma, are similar to infiltrating ductal carcinoma (hematoxylin and eosin stain, x100).


The pathological images of primary breast cancer and the colonic mass. (B) Right-colectomy specimen obtained in 2011, showing poorly differentiated ductal adenocarcinoma. Tumor emboli can be found in some lymph vessels (hematoxylin and eosin stain, x100).


Systemic computed tomography (CT) scan images on admission. . Systemic CT scan showed lymphadenopathies at. Right neck, right
supraclavicular, superior mediastinal, and ,right axillary lymph nodes.


Systemic computed tomography (CT) scan images on admission.
 under tracheal branch.


Systemic computed tomography (CT) scan images on admission. Under tracheal
branch. Evident neoplastic bone lesions were not found.


Pathological images of cervical lymph node biopsy on the 5th hospital day. . Hematoxylin-eosin (HE) staining showed large atypical lymphocytes growing in the
tissue. Immunostaining revealed that tumor cells were CD3(-), CD20(-), CD4(+), CD8(-),
CD30(+), ALK(-), TIA-1(+), PAX5(-), CD68(-), AE1/AE3(-) and Granzyme B(-). CD68-positive
histiocytes were observed around the tumor cells.


Transition of lactate dehydrogenase (LDH), soluble interleukin-2 receptor (sIL2-R),
corrected serum calcium (corrected Ca), and 1,25-dihydroxyvitamin
D3
(1,25(OH)2D3). . Corrected Ca and 1,25(OH)2D3 are improved
in parallel with LDH and sIL2-R. Day 1 is the date of hospitalization. THP:
therarubicin, CPA: cyclophosphamide, VCR: vincristine, PSL: prednisolone, PA: partial
response, CR: complete response.


18F-fluorodeoxy glucose positron emission tomography (FDG-PET) images after
6th cycle of THP-COP therapy. . FDG-PET showed that lymphadenopathy at. Right neck, right
supraclavicular, superior mediastinal, and ,right axillary lymph nodes.


18F-fluorodeoxy glucose positron emission tomography (FDG-PET) images after
6th cycle of THP-COP therapy.
 subcarinal lymph nodes.


18F-fluorodeoxy glucose positron emission tomography (FDG-PET) images after
6th cycle of THP-COP therapy. Pancreas head
had disappeared.


18F-fluorodeoxy glucose positron emission tomography (FDG-PET) images after
6th cycle of THP-COP therapy. No significant accumulations of FDG were observed (D). We confirmed complete metabolic response.


Plasma levels of factor VIII clotting activity (FVIII:C) and von Willebrand factor parameters (VWF:Ag and VWF:Ac) at presentation and during course of treatment. The first set of data points (d0) shows FVIII and VWF levels at initial presentation, while the second set of data points (d3) shows FVIII and VWF levels immediately before the administration of 2,000 IU of FVIII/VWF concentrate, as indicated by the dashed arrow. To assess incremental recovery and residence time of the infused FVIII/VWF, subsequent blood samples were drawn 15 min (d3 ), 60 min (d3. ), and 120 min (d3. ) after concentrate administration. One day later (d4), immunosuppressive therapy with prednisolone was started at a daily dose of 100 mg, which was gradually tapered to 20 mg on d31, as indicated by the solid arrows. One week later, there was a steep decline in FVIII and VWF, both of which readily responded to re-escalating the prednisolone dose to 50 mg per day.


Different treatment periods of cranial MRI. (A-C) Multiple enhancing masses were shown in the corpus callosum and around the ventricles before our interventions.


Different treatment periods of cranial MRI. (D-F) Partial response after two cycles of treatment.


Different treatment periods of cranial MRI. (G-I) No obvious masses after finishing our treatment.


Different treatment periods of cranial MRI. (J-L) 30 months follow-up.


(A) Haematoxylin-eosin (H&E) staining of biopsy samples (40x magnification).


Immunohistochemical staining showed that tumor cells were positive for CD20.


But not for CD30.


Cyclin D1.


CT images after respiratory failure happened. Mediastinal emphysema was occurred after receiving invasive mechanical ventilation. Mediastinal window.


CT images after respiratory failure happened. Mediastinal emphysema was occurred after receiving invasive mechanical ventilation. And lung window.


A; Chart of the patient's medical procedures.


Bone marrow morphology showing acute myeloid leukemia.


A&B - Case 1. Abnormal promyelocytes with rounded nuclei and dense cytoplasmic granularity and hypolobated neutrophils. C&D - Case 2. Relatively scanty cytoplasmic granularity of the promyelocytes. E&F - Case 5. Hypolobulated and hypogranular myeloid cells along with abnormal promyelocytes.


Video-assisted thoracoscopic image of the posterior mediastinal mass.


Medical image.


Submucosal mass in hepatic flexure. Endoscopic appearance of the operative field after excision.


Magnetic resonance imaging brain showing meningeal enhancement in bilateral cerebellar regions.


Magnetic resonance imaging showing leptomeningeal enhancement in the right temporal region.


Magnetic resonance imaging showing leptomeningeal enhancement in the right temporo-occipital region.


Evaluation of the pathogenic potential of the c.5797delC mutation in MYH9. (A) Web-based software Mutation Taster showed that this mutation was disease causing, and the mutation at this position was reported.


Evaluation of the pathogenic potential of the c.5797delC mutation in MYH9. (B) Analysis of amino acid conservation based on the NCBI database.


Chest X-ray and contrast-enhanced computed tomography of the abdomen and thorax. (a) Bilateral mild pleural effusion with irregular opacity in the right upper zone in postero-anterior view of chest X-ray.


Chest X-ray and contrast-enhanced computed tomography of the abdomen and thorax. (b) Antro-pyloric growth in the stomach (solid red arrow) on contrast-enhanced computed tomography abdomen.


Chest X-ray and contrast-enhanced computed tomography of the abdomen and thorax. (c) (empty red arrow) Enlarged para-aortic lymph nodes on contrast-enhanced computed tomography abdomen.


Chest X-ray and contrast-enhanced computed tomography of the abdomen and thorax. (d) (solid yellow arrow) Emphysematous changes in the lung fields on contrast-enhanced computed tomography thorax and (empty arrow) pleural effusion.


Clinical features of dermatomyositis with shawl-like rash affecting neck, chest and back. A; Flagellate erythema upper back.


Clinical features of dermatomyositis with shawl-like rash affecting neck, chest and back. B; 'V' neck distribution of erythema.


Evolution of renal and hepatic function after combined liver-kidney transplantation. Follow up of Creatinine, Prothrombin and Alaninaminotransferase (ALT) levels in the patient before and after transplantation. Creatinine levels dropped immediately after transplant surgery, reaching normal levels 5 days later. The hepatic function normalized during the second week.


Complement profile from 2000 to 2020. Evolution of C3 and C4 levels, and of the C3/C4 ratio, in plasma samples from patient HUS21 since HUS onset in 2000, at the age of 4 months. The horizontal dashed lines indicate the lower limit of normal values. The boxes in the X axis mark the dates of the liver-kidney transplantation (March 2009), and of the second liver transplant (February 2020).


Cerebral diffusion MRI. (A) MRI venography. Left transverse sinus blood flow is not observed (arrow).


Cerebral diffusion MRI. (B) Blood flow is seen inside transverse sinuses (arrows).


Cerebral diffusion MRI. (C) Hyperintense lesions in the occipital region.


Cerebral diffusion MRI. (D) Normal cerebral MR image.


The chest computed tomography showed a large anterior mediastinal cystic mass lateralized to the left side frame evoking a cystic teratoma or a cystic thymoma without aggressive loco-regional signs (arrow).


Gross examination showed a unilocular cystic mass (arrow) with some thymic lobules (star).


Hepatic lesions. In July 2011, CT scan showed occurrence of hepatic lesions.


New hepatic lesion. In October 2012, CT scan showed liver progression for the appearance of a new lesion.


Complete response. In January 2014, CT scan showed a complete response of liver metastases.


Positron emission tomography/computed tomography findings. Positron emission tomography/computed tomography revealed fluorodeoxyglucose accumulation in many pleural lesions.


Positron emission tomography/computed tomography findings. And enlarged mediastinal lymph nodes.


The bone marrow smear. Peroxidase positive blasts were counted at 38.2.


The bone marrow smear. And approximately 20%-30% of the cells were c-kit positive.


A 64-year-old woman with persistent diffuse abdominal pain, admitted for haematemesis and melena. Axial non-enhanced computed tomography demonstrates a homogeneous hyperdense haematoma of approximately 14 cm.


A 64-year-old woman with persistent diffuse abdominal pain, admitted for haematemesis and melena. , haemorrhage within the stomach (arrow.


A 64-year-old woman with persistent diffuse abdominal pain, admitted for haematemesis and melena. And haemoperitoneum (arrow.


A 64-year-old woman with persistent diffuse abdominal pain, admitted for haematemesis and melena. Arterial phase sagittal reconstruction (d) demonstrates moderate coeliac artery compression by the median arcuate ligament with no visible pancreatico-duodenal artery aneurysms.


Brain MRI at admission (A-E). (A, B) Axial view (weighted sequence in T1, T2).


Brain MRI at admission (A-E). (C-E) Sagittal, coronal, axial view after contrast injection, with the tumor marked.


(F, G) Brain MRI after surgery.


(H) Pancreatic cysts.


Representative postoperative pathological images. (A) Histologic examination of optic nerve HGB.


Representative postoperative pathological images. (B-F) Immunohistochemical staining. (B) The proliferative fraction of tumor cells (Ki-67) was low, at approximately 2.


Representative postoperative pathological images. (B-F) Immunohistochemical staining. (C) CD-34 showed abundant blood vessels.


Representative postoperative pathological images. (B-F) Immunohistochemical staining. Tumor cells showed positivity for EGFR.


Representative postoperative pathological images. (B-F) Immunohistochemical staining. , NSE.


Representative postoperative pathological images. (B-F) Immunohistochemical staining. And vimentin.


Surgical pictures. Severe adhesion of the tumor and left optic nerve.


CT scan showing multiple osteolytic lesions of lumbar vertebrae and pelvis.


FDG-PET scan revealing diffuse medullar FDG-uptake.


(A) Chest computed tomography showing multifocal and confluent consolidations with ground-glass attenuation in >50% of the pulmonary parenchyma.


(B) Echocardiogram showing left coronary artery dilatation (red arrow).


Kidney biopsy showing lupus nephritis and thrombotic microangiopathy findings. (A) Histological sections demonstrate proliferative glomerulonephritis and fibrin thrombi in afferent arteriole (trichrome stain, 400x).


Kidney biopsy showing lupus nephritis and thrombotic microangiopathy findings. (B) Immunofluorescence staining revealed fibrin deposition within the intravascular thrombi (fibrinogen antiserum, 400x).


Axial T2 weighted MR image at the level of the posterior fossa revealing a slightly hyperintense infiltrating lesion adjacent to the right side of the fourth ventricle.


Axial T2 weighted MR image after the conclusion of salvage chemotherapy demonstrating the complete disappearance of the lesion.


The transthoracic echocardiogram showed a mass located between the right atrium and the right ventricle. LV: left ventricle, LA: left atrium, RV: right ventricle, and RA: right atrium.


Demonstrating oral mucosal ecchymoses.


On CT plain image, the nodule is slightly low-density lesion in the S4 of the liver (A).


On contrast-enhanced CT images, the lesion showed slight enhancement in arterial phase.


Slight washout in portal phases The white arrow points to the lesion. Malignant tumor could not be excluded.


Fat-saturated T1-weighted image (A) showed a hypointense lesion measuring 17 mm in the segment 4 of the liver.


The lesion showed hyperintensity on T2-weighted image (B).


On enhanced T1-weighted images, the lesion showed obvious enhancement in arterial phase.


In portal phase. The lesion showed slight washout and perinodular enhancement.


On DWI.


ADC. Images, the lesion showed a significant diffusion restriction. The white arrow points to the lesion.


18FDG PET-CT images. Maximum intensity projection PET (A).


18FDG PET-CT images. Transverse CT (B) showed a slightly low-density lesion in segment 4 of liver.


18FDG PET-CT images. Corresponding PET.


18FDG PET-CT images. Fused. Images showed increased FDG uptake with SUVmax of 4.81.


18FDG PET-CT images. Corresponding PET image (E) after 1.5 h delay showed the FDG uptake that continued to increase with SUVmax of 5.24, and the detention index was 8.9%. However, the lesions in the S7 and S5 of the liver showed no significant increase in FDG uptake.


Pathological findings with hematoxylin-eosin (HE) staining showed that there were a large number of reactive proliferative lymphoid follicles in the tumor area, and the germinal center was composed of non-dysmorphic lymphocytes or plasma cells, fibrous collagen, and hyaluronic matrix, and remaining normal bile ducts (red arrows) can be seen along the edge of the lesion (A, HEx100).


Lymphoid tissues grow around the small bile ducts (B, HEx200).


A uniform red-stained matrix deposit can be seen in the lesion (C, HEx400).


The results of immunohistochemistry showed that CD20-positive lymphocytes grew around the small bile ducts (D, IHCx200).


CD3. IHCx100).


CD10. IHCx40).


CD23. IHCx40).


Ki-67. IHCx40) staining showed reactive proliferative lymphoid follicles in the lesion.


WB-CT scan at diagnosis of patient 1. Posterior mediastinal mass paravertebral to T9-T11 vertebral bodies.


WB-CT scan at diagnosis of patient 1. , bilateral adrenal lesions.


WB-CT scan at diagnosis of patient 1. And periaortic and peri-common iliac artery lesion with an extensive encasement of this vessel.


Abdominal-CT . Before bilateral adrenalectomy: adrenal lesions on the right.


Abdominal-CT . Left. Adrenal gland.


MRI scan Coronal in-phase.


MRI scan out-of-phase. MRI images with no loss of signal in the mass.


Abdominal-CT scan before left adrenalectomy showing a 17mm nodule on the left adrenal gland.


The condition of the right and left eyes at admission: subconjunctival hemorrhage, chemosis, dense, in the form of a "roller" infiltration of the conjunctiva, partially covering the limb zone.


Zone of corneal ulceration (white arrow).


Right eye. Optical coherence tomography (Heidelberg Spectralis ) a zone of sharp thinning of the stroma in the paralimbal zone, the structure of the stroma was loose, adjacent to the zone of the ulcer defect was accompanied by a zone of perifocal edema. Similar changes were observed at all levels of scanning along the limbal zone.


Left eye. In the paralimbal zone with the established zone of destruction of the deep layers of the stroma, covered with a tear film. Peripheral damage was noted as "stepped," which was biomicroscopically corresponding to the active edge of an ulcerative defect. In contrast to the heterogeneous structure of the endothelium, corresponding to single precipitates.


Hematoxylin and eosin stain. 20x of biopsy showing a patchy infiltrative pattern. Chronic granulomatous inflammatory infiltrate and focal areas of necrosis (white arrows).


Magnetic resonance imaging conducted at first diagnosis showing soft tissue-masses (yellow arrows) with infiltration of the right humerus.


The right pleura.


FDG-Positron emission imaging at first relapse of ALCL showing hypermetabolic lesions around the spine.


Within the right scapula.


Photographic documentation and positron emission imaging at second relapse of ALCL.


At 3 months after start of crizotinib treatment.


Left upper lid mass.


Intraoperative photo of biopsy demonstrating extensive bony erosion of the superior orbital rim.


Positron emission tomography-magnetic resonance imaging fusion with T1 radial volumetric interpolated breath-hold examination with fat suppression acquired in the axial plane showed severely decreased radiotracer activity throughout the liver parenchyma (white arrow) (a).


Corresponding axial T1 radial volumetric interpolated breath-hold examination with fat suppression image (b) revealed generalized decreased magnetic resonance signal in the liver.


Axial positron emission tomography attenuation corrected image.


Showed severe decreased liver uptake (black arrow) which was not present on the nonattenuation corrected images.


Dixon three-dimensional volumetric interpolated breath-hold examination T1-weighted magnetic resonance sequence in the coronal plane demonstrates normal signal intensity in the liver parenchyma (arrow) on the out-of-phase image.


With drop in signal on the in-phase image indicating excessive iron accumulation.


The mu map showed the expanded boundary of the right lung instead of the correctly assigned soft-tissue density of the liver parenchyma (curved arrow) (c).


The coronal attenuation mu map was manually segmented by filling in the faulty liver reconstruction (thin arrow) with soft-tissue density instead of lung tissue (a). The resulting attenuation corrected positron emission tomography image in the coronal plane showed the properly corrected liver parenchyma tracer activity (thin arrow).


Unrelated to the liver, multiple osseous metastases are noted on the study (arrowheads) (b).


Fluorodeoxyglucose positron emission tomography-magnetic resonance imaging scan after oral chelator therapy with attenuation corrected positron emission tomography axial image demonstrating normal fluorodeoxyglucose uptake within the liver (a).


Corresponding T1 radial volumetric interpolated breath-hold examination with fat suppression image showed improved liver signal intensity reflecting decreased iron deposition (b).


Follicular dendritic cell sarcoma in mediastinum in 47-year-old man. . A. Unenhanced CT image of thorax reveals well-defined posterior mediastinal mass of homogeneous attenuation (white arrows) with arborizing-pattern of calcification (black arrow).


Follicular dendritic cell sarcoma in mediastinum in 47-year-old man. . B. Contrast-enhanced CT image shows marked homogeneous enhancement of mass. Note compression of left atrium (black asterisk) and displacement of esophagus (white arrow).


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. . A. Image of air-barium double-contrast study shows broadening of incisura due to extrinsic compression along lesser curvature of stomach (black arrows). Overlying mucosa appears to be intact.


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. B. Unenhanced CT image of upper abdomen shows large heterogeneous mass (white arrows) located between stomach and left lobe of liver.


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. C. Contrast-enhanced CT image during arterial phase shows heterogeneous moderate enhancement of tumor. Note feeding arteries in periphery of tumor (black arrows).


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. D. Portal venous phase image shows heterogeneous moderate contrast enhancement of tumor (white arrows).


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. E. Histopathological appearance reveals that tumor is composed of spindle cells that are arranged in storiform and whorled pattern and these spindle cells are admixed with lymphocytes (Hematoxylin & Eosin stain, x 100).


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. F. Tumor shows positive immunohistochemical staining for CD21 (paraffin immunohistochemical stain, x 100).


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. G. T1-weighted image shows hypointense metastatic nodule in right lobe of liver (white arrow).


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. H. Nodule is hyperintense with hypointense center on T2-weighted image (white arrow).


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. I. T1-weighted arterial-phase contrast-enhanced image shows isointensity of nodule (white arrow) due to homogeneous enhancement.


Follicular dendritic cell sarcoma in upper abdomen in 28-year-old woman. J. T1-weighted portal-phase enhanced image shows heterogeneous, mild hypointensity of nodule (white arrow).


Follicular dendritic cell sarcoma of cervical lymph node in 38-year-old man. . Unenhanced axial CT image reveals well-delineated homogeneous right submandibular mass that compresses adjacent structures (white arrows). Small area of mild hypodensity (black arrow) is present in mass.


Follicular dendritic cell sarcoma of cervical lymph nodes in 35-year-old woman. . A, B. Enhanced CT images show multiple enlarged lymph nodes with homogenous moderate enhancement (white arrows) in left parotid gland region.


Magnetic resonance images for patient 1. (a) Preoperative postcontrast T1 sagittal, avidly enhancing mass measuring 3.6 cm anterior-posterior (white arrow) along the tentorium, compressing the aqueduct of Sylvius. Tentorial angle is excessively steep (black arrow), which prohibits an infratentorial approach.


Magnetic resonance images for patient 1. (b) Preoperative postcontrast T1 coronal, redemonstration of hyperintense mass measuring 3 cm transverse (white arrow).


Magnetic resonance images for patient 1. (c) Preoperative postcontrast T1 axial, hyperintense mass measuring 3.5 cm cranial-caudal (white arrow).


Magnetic resonance images for patient 1. (d) Postoperative postcontrast T1 sagittal, postsurgical changes demonstrating gross total resection of pineal region mass (white arrow).


Magnetic resonance images for patient 1. (e) Postoperative postcontrast T1 coronal, postsurgical changes demonstrating gross total resection of pineal region mass (white arrow).


Magnetic resonance images for patient 1. (f) Postoperative postcontrast T1 axial, postsurgical changes demonstrating gross total resection of pineal region mass (white arrow).


(a) Surgical position keeping sagittal plane parallel to the floor.


(b) Craniotomy exposing bilateral dura as well as torcula.


Magnetic resonance images for patient 3. (a) Preoperative postcontrast T1 axial, homogeneously enhancing infratentorial paramedian lesion with high perilesional vascularity (black arrow).


Magnetic resonance images for patient 3. (b) Preoperative postcontrast T1 coronal, showing tentorial attachments.


Magnetic resonance images for patient 3. (c) Preoperative postcontrast T1 sagittal, showing a homogeneously enhancing mass with perilesional vascularity, and steep tentorial angle.


Magnetic resonance images for patient 3. (d) Postoperative (5 months) postcontrast T1 axial, demonstrating minimal tentorial enhancement and vascular clips artifact.


Magnetic resonance images for patient 3. (e) Postoperative postcontrast T1 coronal, demonstrating gross total resection and vascular clips artifact.


Magnetic resonance images for patient 3. (f) Postoperative noncontrast T1 sagittal, showing postsurgical changes.


Magnetic resonance images for patient 4. (a) Preoperative postcontrast T1 axial, showing heterogeneously enhancing superior vermian lesion without hydrocephalus.


Magnetic resonance images for patient 4. (b) Preoperative postcontrast T1 coronal.


Magnetic resonance images for patient 4. (c) Preoperative postcontrast T1 sagittal, showing a heterogeneously enhancing mass with a displacement of tectal plate and steep tentorial angle.


Magnetic resonance images for patient 4. (d) Postoperative postcontrast T1 axial, demonstrating minimal surgical cavity and residual lesion.


Magnetic resonance images for patient 4. (e) Postoperative postcontrast T1 coronal, demonstrating partial resection.


Magnetic resonance images for patient 4. (f) Postoperative noncontrast T1 sagittal, demonstrating postsurgical changes.


T1-weighted sagittal view showing a hypointense lesion in the posterior fossa, with displacement of the brainstem and the cerebellum.


T1-weighted axial view showing mildly enlarged ventricles and a contrast-enhancing lesion in the posterior fossa, exerting mass effect on the brainstem.


(A) Luteinized follicle containing a structure suggestive of an ovum undergoing degeneration (hematoxylin and eosin stain; magnification, x150).


(B) Higher magnification of the putative ovum (hematoxylin and eosin stain; magnification, x250).


(C) Higher magnification of the same follicle showing luteinized cells characterized by their larger size, abundant eosinophilic cytoplasm, and prominent nucleus (hematoxylin and eosin stain; magnification, x250).


Serum estradiol correlated with maximum follicle diameter in normal women but not in women with Overt POI. (A) Each point represents the findings in 1 of 10 normal women with regular menses examined during the follicular phase. Two congruent points are noted by (2).


Serum estradiol correlated with maximum follicle diameter in normal women but not in women with Overt POI. (B) Each point represents the findings in a patient with overt POI who had an ovarian follicle detected by sonogram (37 sonograms in 27 patients). There are 8 congruent points (Nelson et al.


Serum estradiol response to stimulation with 300 IU FSH. (A) Control women, women with Overt POI, and women with overt POI segregated by the absence or presence of an antral follicle 8 mm in diameter or greater (***P < 0.0001 vs. Baseline).


Serum estradiol response to stimulation with 300 IU FSH. (B) Change in serum estradiol levels at 24 h.


(A) Mean (SEM) percentage change from screening in the femoral neck BMD.


(B) Mean (SEM) percentage change from screening in the lumbar spine BMD (Popat et al.


Initial brain MRI in the patient with multifocal demyelinating leukoencephalopathy after accidental consumption of levamisole;. Brain MRI on T1WI revealed multifocal subcortical white matter lesions in the periventricular.


Brain MRI on T2WI revealed multifocal subcortical white matter lesions in the periventricular, cerebellar, and ,pons.


Brain MRI on FLAIR revealed multifocal subcortical white matter lesions in the periventricular area, cerebellum and pons.


BCR-ABL percentage in the course of the disease.


Phylogenetic Tree Constructed Based on Partial ORF2 Nucleotide Sequences (304 nt) by the Neighbor Joining Method Using MEGA 5.2. Statistical confidence for the tree was assessed by bootstrap analysis (the search option was 500 replications); bootstrap values greater than 85 were shown. The scale bar indicating the number of character state changes is proportional to the genetic distance. Database derived sequences are denoted by their GenBank accession numbers. The HEV isolate,BDJ1 (GenBank accession number, KF691589) from this study is indicated by a thick line.


CD20 B-cell stain showing a nodular pattern with widened marginal zones.


Metaphase FISH analysis using the Vysis IGH break-apart probe. The normal chromosome 14 shows colocalization of the two probes, the derivative chromosome 14 has retained the 3'IGH signal (spectrum orange) and the 5'IGH signal (spectrum green) has translocated to chromosome 2.


Metaphase FISH analysis using the RP11-542H15 probe (spectrum green) and the Vysis MYCN probe (spectrum orange). The normal chromosome 2 shows colocalization of the two probes, the derivative chromosome 2 has retained the RP11-542H15 probe (spectrum green) and the MYCN probe (spectrum orange) has translocated to chromosome 14.


Air contrast barium enema showed multiple thumbprint-like lesions (arrows), ranging from 7 to 20 mm in diameter, mainly in the ascending colon.


Endoscopic views of a cluster of elevated lesions, with a smooth surface and gentle slope, in the ascending colon. (A, B) The overlying mucosa was intact and appeared thin, and the lesion was soft and compressible.


EUS images of the colon, obtained with a catheter EUS probe (frequency 12 MHz). (A) The EUS image depicting elevated lesions as echo-free cysts (arrowheads) in the submucosal layer.


EUS images of the colon, obtained with a catheter EUS probe (frequency 12 MHz). (B) Some submucosal cysts had septal walls (arrows).


Microscopic findings. (A) Endoscopic biopsy revealed submucosal cyst with occasional multinucleated cells (inset), however, there were no fat or blood cell components (H&E, x20; inset: H&E, x400).


Microscopic findings. (B) D2-40 immunostaining showed positive reactivity (arrows) for lining endothelial cells of lymphatic spaces (Polymer method, x200).


(A) A 68-year-old female with relapse of known Mantle cell lymphoma (MCL) resulting in swelling of the left sublingual gland. Magnetic resonance imaging (MRI) showing a tumor of the left sublingual gland (white arrow). Histological image of the sublingual gland MCL Salivary gland tissue is infiltrated by lymphoid tumor tissue and small tumor cells are seen with multiple membrane bound nucleoli. Ductal structures are seen (black arrow) (HE).


Medical image.


(C) A 61-year-old male with 1-month history of painless swelling of the floor of the mouth. Tumor tissue was composed of neoplastic lymphoid cells with irregular nuclei and plasmacytic differentiation, consistent with a diagnosis of extranodal marginal zone lymphoma (EMZL) of the left sublingual gland. Scattered ductal structures are seen (black arrow) (HE). Immunohistochemistry of the sublingual gland EMZL. Showing positive reaction for lambda light chain. Scale bar = 50 mum.


Computed tomography images. Multiple lymphadenopathies are observed in the hilar and mediastinal lymph nodes.


Computed tomography images. And inguinal lymph nodes.


Oesophagogastroduodenoscopy images. A slight elevation of the mucosa and partial change in the mucosal colour to off-white are observed in the gastric body (A).


Oesophagogastroduodenoscopy images. Close examination.


Oesophagogastroduodenoscopy images. Magnified observation. Showed elongated and distorted microvessels.


Oesophagogastroduodenoscopy images. Magnifying observation with narrow-band imaging revealed that the gastric pits were preserved (D).


Literature search of primary intracranial leiomyosarcoma in adult population reported in the English literature till date.


Hypocellular bone marrow with 10% hematopoietic cells, predominance of erythroid
lineage cells, and abundant hemosiderin deposits (3+/4+). Hematoxylin and eosin
staining, 400 x original magnification.


Cytology of lymph node showing polymorphous population of lymphoid cells, isolated epithelioid cells, and plenty of extra- and intracellular Leishman-Donovan bodies (Leishman and Giemsa stain, high-power view).


Cytology of the lymph node revealing intra- and extracellular Leishman-Donovan bodies and macrophages (Leishman and Giemsa, high-power view).


The tumor had been treated with prone position.


Skin incision line.


Surgical view.


Gross-total surgical excision. Craniotomy Tumor Removal Transvermian.


Histological examination, magnification 100x.


200x. Shows carrot-shaped cell with polimorfic hyperchromatic nuclei and Homer Wright Rossetes appearance as patognomonic sign for medulloblastoma.


Abdominopelvic CT scan: A & B) Dilated tortouous hepatic arteries with mutifocal arterio-venous shunts in liver, arterio-venous malformation in ileal wall. C) Coronal view.


Ulcerated lesions on the scrotum.


Lower abdomen. Of the patient.


Computed tomography scan of the chest showing non-enhancing right pleural lesion abutting the anterior and lateral chest wall causing passive atelectasis of the underlying lung. Mild pleural thickening is also noticed.


Histopathology specimen of the pleural mass showing blood clots and few newly formed blood vessels (x10 hematoxylin and eosin stain).


A, b: Light microscopy shows no spike formation or bubbling in the glomerular capillary wall (periodic acid-methenamine-silver staining x 400).


A, b: Light microscopy shows no spike formation or bubbling in the glomerular capillary wall (periodic acid-methenamine-silver staining x 400). B: Enlarged image.


IgA (alpha-heavy chain).


IgA1 (alpha1-heavy chain).


Kappa-light chain.


Lambda-light chain.


Medical image.


A: Electron microscopy shows extensive foot process effacement of the podocytes, which contain large amounts of electron-dense materials mainly in the area covering the surface of the glomerular basement membrane. Bar = 10 microm.


B: In higher magnification (inside the black square of Figure 3a), small amounts of electron-dense deposits are seen beneath the cytoplasm of the podocytes containing the dense materials (arrows). Bar = 1 microm.


The disease history of the patient. The blue circle indicates the lesion.


X-ray cervical spine showed osteolytic destruction of C2 body with subluxation of C1 and C2 complex over C3.


X-ray showing occipito-C1-C3 lateral mass screws fixation with vertex Medtronic system.


(a and b) Histopathological examination showed spindle cells arranged in whorls and fascicles with proliferation of smooth muscle cells surrounding the blood vessels. Spindle cells showed eosinophilic cytoplasm with elongated nuclei with blunt ends.


There is moderate cellularity, minimal atypia, inconspicuous mitosis, and no evidence of necrosis; (c and d) Immunohistochemistry of the tumor cells stained positively for smooth muscle actin, and negative for S-100 protein.


Post operative magnetic resonance imaging at 1 year showed small residual tumor at C2 body.


Cryoglobulin pseudothrombi and double contouring of basement membrane (Jones silver, x450).


Protein electrophoresis. A sharp monoclonal band is seen (arrow), which has been replaced with a polyclonal pattern after 14 months of treatment.


CT multiplanar reconstruction showing a tumour (34x27x51 mm with 5 mm calcification) suspected of being an ovarian cancer. The arrows point out the lesion.


CT multiplanar reconstruction showing diffuse alveolar haemorrhage in course of granulomatosis with polyangiitis.


Virtual reality 3D reconstruction from CT scan (presented on figure 2) showing diffuse alveolar haemorrhage in course of granulomatosis with polyangiitis.


CT scan showing an intranasal mass involving the bilateral ethmoid sinuses with the destruction of the ethmoid septae and the medial wall of the left orbit.


Clinicopathologic features of the four cases.


Bone marrow smear (x100 magnification) showing normal trilineage hematopoiesis with the presence of erythroid precursors.


Trends of hemoglobin with age in this patient. Preoperative hemoglobin,. Hemoglobin before taking amiodarone,. Hemoglobin after 4 months of amiodarone administration,. Hemoglobin before treatment with prednisone,. Hemoglobin after 3 months of prednisone administration. The first one: Hemoglobin 1 month before amiodarone administration, The second one: Hemoglobin 1 month after amiodarone administration, The third one: Hemoglobin 2 months after amiodarone administration.


A: Scrotal ultrasound showing a well-circumscribed mass of mixed heterogeneous echogenicity on the right side.


B: Doppler ultrasound demonstrating increased vascularity of the lesion.


Intraoperatively: asterisk: Spermatic cord mass.


Interlacing fascicles of spindle cells with high cellularity and atypical mitosis.


Muscle MRI of upper legs. In this representative transverse axial T1 weighted image from the patient, increased signal intensity is seen in the bilateral adductor magnus, semitendinosus, and semimembranosus muscles.


Levels of anti-SARS-CoV-2 N IgG antibodies in the concentrate antibody solution infused to the patient, in antibody donor serum and in recipient sera collected before antibody infusion (day 0) and 7, 14, and 22 days thereafter. The dashed line indicates the threshold for antibody positivity.


Patient serum-induced ex vivo C5b-9 deposition . (A) HMEC-1 were incubated for 2 h with serum (diluted 1:2 with test medium, HBSS with 0.5% BSA) from the patient or with a control serum pool. At the end of incubation, cells were washed, fixed, and stained with rabbit anti-human complement C5b-9 complex antibody followed by FITC-conjugated secondary antibody. Fluorescence microscopy was used to view the fluorescent staining on endothelial cell surface, and the HMEC-1 area covered by C5b-9 staining was calculated by automatic edge detection (Image J software) in 15 high power fields. For each sample, the highest and the lowest values were discarded and the mean of the other 13 fields was calculated, and values were expressed as the percentage of C5b-9 deposits induced by a pool of sera from 10 healthy controls run in parallel (reference 100%). Dashed lines indicate upper and lower limit of normal range.


Thrombi formation. On cultured Human Microvascular Endothelial Cells (HMEC-1) line immediately before antibody infusion (Day 0), and 1, 7, 14, and 21 days thereafter. (B) HMEC-1 were activated with ADP and exposed for 2 h to serum (diluted 1:2 with test medium, HBSS with 0.5% BSA) from the patient or with a control serum pool. Perfusion of heparinized whole blood (heparin 10 U/ml) from an healthy subject (added with the fluorescent dye mepacrine 10 microM, to label platelets) was then performed in a thermostatic flow chamber (37 C) in which one surface of the perfusion channel was a glass slide seeded with a monolayer of endothelial cells at a constant flow rate of 1500 sec-1 (60 dynes/cm2). After 3 min, perfusion was stopped, and the slide with the endothelial cell monolayer was dehydrated and fixed in acetone for 20 min. Slides were examined under confocal inverted laser microscopy. Fifteen fields for each slide were systematically digitized along the surface and the area covered by thrombi was quantified by Image J (NIH, Bethesda, MD), and expressed as pixel2 per field analyzed. For each sample the mean of 15 fields (excluding the lowest and the highest values) was calculated. Dashed lines indicated the area covered by thrombi of control serum pool +- SE. Data are reported as means +- SE. P<0.0001,. P<0.001 versus control serum pool; ^P<0.0001 versus day 0; *P<0.0001 versus day 1; #P<0.0001, ##P<0.001 versus day 7. Statistical analysis: ANOVA.


D-Dimer levels in patient plasma samples collected before antibody infusion (Day 0) and 1, 7, 14, and 21 days thereafter. Dashed line represents the upper normal reference value.


Computed tomography of the chest showed irregular pleural thickening and pleural effusion in the left lung.


Pathologic features of an incisional biopsy of the pleura. (A) The growth pattern of the tumor is infiltrative with a desmoplastic stroma (H&E, x 100).


Pathologic features of an incisional biopsy of the pleura. (B) The tumor cells shows oval to spindled and indented nuclei and abundant cytoplasm with indistinct border (H&E, x 400).


Immunohistochemistry showed that the tumor cells were positive for. S100.


CD 45 (x 400).


Corresponding positron emission tomography (PET)-CT image showed 18-fluoro-deoxyglucose (FDG) uptake (standardized uptake value, SUV, 10.5 and 9.8), by thickened pleura of the left hemithorax and the whole axial skeleton, which was compatible with malignant tissue.


Medical history, log TSH, and LT4 dose per bodyweight of the case patient. The dose of sertraline and ethynyl estradiol were 50 mg per day and 0.03 mg per day, respectively. The beginning dates of each medication were May 2015, September 2015, and September 2016. There was fluctuation of serum TSH level in spite of increasing LT4 dose over bodyweight. LT4, levothyroxine; Bwt, bodyweight.


X-ray showing lesion on skull.


Histopathology of lesion removed from skull.


Preoperative computed tomography (CT) head showing bilateral subdural hematomas.


Postoperative CT head, with bilateral subdural drains intact.


3-week postoperative CT head, after daptomycin administration and removal of subdural drains.


(a) Preoperative radiograph showing periapical radiolucency and immature roots in teeth number 11, 21.


(b) Platelet-rich fibrin membrane.


Mineral trioxide aggregate apical stops formed against a barrier of platelet-rich fibrin membrane.


Postoperative intraoral periapical radiograph showing healing.


Preoperative radiograph of tooth number 21 showing periapical radiolucency, and ,immature apex in tooth number 21.


Postoperative radiograph at 1-year showing formation of calcific apical barrier and resolution of radiolucency.


Arrow showing subgaleal hematoma over Lt Posterior parietal area.


Axial CT scan of head shows Rt parietal heterogeneously hypodence biconvex extradural lesion.


X-ray skull showing increased marrow proliferation with thin cortical bone margins.


X-ray skull showing break in continuity of inner skull margin.


Trephine craniotomy showing altered blood and its degraded product in extra dural space.


Craniotomy bone clearly showing increased hematopoietic skull tissue Proliferation with thin cortical bone margin.


Inner surface of Craniotomy bone showing papery thin cortex with areas of Blackish discoloration and pinpoint bleeding sitesdischarged.


Histo pathological examination of a bone piece reviled hyper-proliferative bone marrow.


CT scan after 3 months of surgery at the time of follow up, showing previous craniotomy site with normal brain scan.


Time course depicting the clinical presentation of IgG4RD, laboratory results and treatment plans from 2009 to 2020. Chronic phase of the patient's disease: the upper part summarizes the specific features of clinical findings, biopsy, imaging, and immunological laboratory results; the lower part shows the therapy, specifying dose, duration, and dates for Rituximab infusions (deep red diamonds) and steroids (sky blue bars). Pulse treatment with methyl-prednisone (500mg i. v. ) is represented by the bottom scale blue bars and was usually followed by oral Prednisone (top scale blue bars); the dashed bar corresponds to the period when the patient did not adhere thoroughly to the prescribed therapy.


In the acute phase, the upper part shows the laboratory values for CFH (black, mug/ml), anti-CFH (pink, AU/ml), left y-axis, and thrombocytes (green, G/l) at the right y-axis. The normal reference values are shown with shades matching the colors of the different parameters. The lower part depicts the therapy including methylprednisolone/prednisone (sky blue bars, mg/d), plasma exchanges (deep blue arrows), and cyclophosphamide (purple triangles, 500 mg i. V. ). The time when TMA and COVID-19 were diagnosed are shown with symbols. AU, arbitrary units; BM, bone marrow; Covid-19; coronavirus disease 2019; CT, computed tomography; CTX, cyclophosphamide; HPF, high-power field; IgA, immunoglobulin A; IgG4-RD, immunoglobulin G4-related disease; i. V. , intra venous; PET-CT, positron emission tomography-computed tomography; PLEX, plasma exchange; RTX, Rituximab; SARS-CoV-2 severe acute respiratory syndrome coronavirus 2; TMA, thrombotic microangiopathy.


Identification of IgG4 anti-factor H autoantibodies: Plasma samples were analyzed for anti-factor H antibodies by a previously reported specific ELISA which was developed using Horse Radish peroxidase (HRP)-labeled secondary antibodies specific for human IgG, IgG4, and IgA, respectively. Data are shown as optic density at 490 nm (OD). (A) The patient's serum was tested in duplicates at different dilutions 1:100, 1:400, and 1:1,000 for both IgG (black bars) and IgG4 (grey bars). Controls included a normal human serum (NHS), a serum with known elevated anti-CFH IgG levels, and a serum with elevated IgG4 but no anti-CFH activity.


Glomerulus showing accumulation of plasma-like material in the widened subendothelial area globally (star mark). One of them shows presence of red blood cells in the microaneurysmal space (black arrow) at the tubular pole (x40, periodic acid-schiff methenamine silver stain).


Ultrastructure of glomerular capillary wall revealing marked widening of the subendothelial spaces by electron-lucent material (star mark) and fibrin tactoids (white arrow). New basement membrane layer is seen on the inner aspect. Overlying podocytes show diffuse effacement of foot processes (x9300, uranyl acetate and lead citrate).


Doppler ultrasound of the temporal artery.


Postmortem biopsy of temporal artery. White arrow: mononuclear infiltration in the inner layer of the temporal artery. Black arrow: multinucleated giant cell infiltration.


Low power magnification 'touch preparation' bone marrow biopsy showing dense infiltration with lymphoid type blasts.


Magnification x 400 showing blasts with an undifferentiated appearance and some with vacuoles.


Schematic representation showing timeline of treatment course and clinical information. FLAI-5, fludarabine-cytarabine-idarubicin; Allo-SCT, allogeneic stem cell transplantation; WBC, white blood cells; Hb, hemoglobin; PLTs, platelets.


Sanger sequencing chromatogram showing the FLT3 deletion identified in the BM at diagnosis. TMD, transmernbrane domain; JMD, juxtamembrane domain; TKD, tyrosine kinase domain.


Effects of increasing doses of midostaurin on the clonogenic capacity of primary BM and PBL cells carrying the reported FLT3 deletion (c.1770_1784del15; p. Phe590_Arg595delinsLeu).


Radiograph of the affected hand at the time of initial presentation.


Photomicrograph showing hemophagocytosis in bone marrow.


Microphotograph showing both intracellular and extracellular LD bodies in splenic aspirate (Giemsa, 100X).


MR-imaging during disease course. Sagittal FLAIR- and axial T1 gadolinium sequences. (A) Moderate lesion load under fingolimod treatment.


MR-imaging during disease course. Sagittal FLAIR- and axial T1 gadolinium sequences. (B) Frontoparietal tumefactive lesions with disseminated Gadolinium-enhancement 6 weeks after discontinuation of fingolimod.


MR-imaging during disease course. Sagittal FLAIR- and axial T1 gadolinium sequences. (C) Remittent Gadolinium-enhancement after four cycles of plasmapheresis.


MR-imaging during disease course. Sagittal FLAIR- and axial T1 gadolinium sequences. (D) Further remission at re-admission 2 weeks after the last cycle of plasmapheresis; asterisk indicates active lesion.


MR-imaging during disease course. Sagittal FLAIR- and axial T1 gadolinium sequences. (E) Lesions decreasing in size 6 months after ocrelizumab initiation (only axial FLAIR available).


Clinical course and total lymphocyte count. Total lymphocyte count (TLC)/mul is depicted over the disease course. Relapses are shown as red squares. Duration of disease modifying therapies is shown with the black symbols, respectively. Ocrelizumab therapy was initiated and is still ongoing.


Clinical images of Case 2. (A1) Brain MRI with contrast showed suspicious reinforcement in the epencephalon and some ischemic areas in the frontal, parietal, and occipital lobes before EGFR-TKI therapy; (A2) Brain MRI showed multiple ischemic foci and lacunar infarction, encephalatrophy, and demyelination in white matter after EGFR-TKI therapy; (B) Chest CT with contrast of patient 2 showed partial response in chest lesions after EGFR-TKI treatment.


Clinical images of Case 5. (A1) Brain MRI showed multiple nodules in the brain, and metastatic tumor was considered; (A2) Brain MRI showed more ischemic foci and lacunar infarction in the bilateral frontal and parietal lobes and demyelination after 3 months of EGFR-TKI therapy; (A3) Brain MRI showed shrinking metastatic tumor in the brain, more and more ischemic foci and lacunar infarction in the bilateral frontal and parietal lobes, and demyelination after 6 months of EGFR-TKI therapy; (B) Chest CT with contrast of patient 5 showed the gradual disappearance of pulmonary nodules after EGFR-TKI treatment.


Imaging for Case 1. . Notes: Pre-treatment. Fused axial PET/CT images of the patient's left-sided primary breast lymphoma Pre-treatment imaging revealed mildly FDG-avid left breast changes at the site of biopsy-confirmed DLBCL.


Imaging for Case 1. . Notes: Pre-treatment. And gastrointestinal stromal tumor of the pancreatic head Pre-treatment imaging revealed a 5.0 x 6.0 cm duodenal/pancreatic head mass with significant FDG avidity.


Imaging for Case 1. And post-treatment. Fused axial PET/CT images of the patient's left-sided primary breast lymphoma , with resolution of these findings after six cycles of R-CHOP chemotherapy.


Imaging for Case 1. And post-treatment. And gastrointestinal stromal tumor of the pancreatic head ; this decreased in size to 4.6 x 5.2 cm after 10 months of imatinib, with continued FDG avidity, suggesting persistent disease despite partial response . Abbreviations: DLBCL, diffuse large B cell lymphoma; FDG, fluorodeoxyglucose; PET, positron emission tomography; R-CHOP, rituximab/cyclophosphamide/doxorubicin/vincristine/prednisolone.


Case 1 GIST surgical resection pathology findings. . Notes: (A) Gastrointestinal stromal tumor involving the wall of the duodenum (arrowhead). The neoplastic cells showed epithelioid morphology with focal areas of spindle cell morphology. Mitotic figures were few (<5 per 50 high-power fields).


Case 1 GIST surgical resection pathology findings. (H&E stain; 100x original magnification) (B) DOG1 immunohistochemistry showed diffuse positive staining.


Case 1 GIST surgical resection pathology findings. (C) Bcl-2 immunohistochemistry showed diffuse positive staining. (Immunohistochemistry with hematoxylin counterstain; 100x original magnification).


Case 2 GIST surgical resection pathology findings. . Notes: (A) GIST comprised of neoplastic cells with spindle cell morphology exhibiting a herringbone growth pattern. Mitotic figures were few (<5 per 50 high-power fields).


Case 2 GIST surgical resection pathology findings. (H&E stain; 100x original magnification) (B) CD117 immunohistochemistry showed diffuse positive staining. (Immunohistochemistry with hematoxylin counterstain; 100x original magnification). . Abbreviation: GIST, gastrointestinal stromal tumor.


Cytomorphologic and cytogenetic results. (A) A representative cytomorphologic bone marrow field, showing blasts with Auer rods (arrow) and azurophilic inclusions.


Cytomorphologic and cytogenetic results. (B) A representative metaphase cell demonstrating normal chromosomes 15 and 17, and more than 20 double minutes (red arrowheads).


Cytomorphologic and cytogenetic results. Metaphase FISH of this patient with the ON MYC(green)/IGH(red) t(8,14) Fusion Probe (Kreatech), showing MYC-positive dmins (green), and ,both chromosomes 14 (arrow).


Cytomorphologic and cytogenetic results. In this cell it was not possible to indicate the normal chromosome 8 due to the high number of dmins. Metaphase FISH with a BAC-probe RP1-80K22 (base pair position 128,667,455-128,814,588) for MYC gene (red) and a flanking BAC-probe RP11-125A17 (base pair position 128,865,417-129,036,660; green), demonstrating multiple copies of dmins (red-green signals). Only one chromosome 8 (arrow) contains the MYC gene region.


X-ray plain film of bilateral hip joints. The left femoral epiphysis was irregular with bone defect areas at both outer and inner margins; the space of the left hip joint had local stricture; peripheral spindle-shaped soft tissue density shadows were observed. The right acetabulum was thickened and the density was increased.


CT images of bilateral hips. The left femoral head was irregular with rough margins, the bone trabeculae were unclear; cortical bone fracture and small free bone fragments were observed.


The horizontal MRI of bilateral hip joints, the femoral head and acetabular articular surfaces were rough.


The coronal MRI of bilateral hip joints, the left acetabulum became shallow, the femoral head was shifted upward slightly.


Laboratory tests for patient one as a function of time. Abbreviations: dL, deciliter; g, gram; L, liter; LDH, lactate dehydrogenase; mg, milligram; uL, microliter.


Laboratory results for patient two as a function of time. Abbreviations: dL, deciliter; g, gram; L, liter; LDH, lactate dehydrogenase; mg, milligram; uL, microliter.


Contrast-enhanced CT-scan with detection of multiple hypodense pancreatic lesions.


Histologic features of the core-needle biopsy. The lesion was constituted of malignant smooth muscle fascicles, as demonstrated by the immunohistochemistry for smooth muscle actin (SMA) and pool cytokeratin (CK, which is shown to have a positive control on the normal lung parenchyma left).


Illustrations of lesions of the patient. Lesions at the natal cleft.


Illustrations of lesions of the patient. Lesions at the Achilles tendon.


Illustrations of lesions of the patient. Lesions at the elbows.


Illustrations of lesions of the patient. Lesions at the upper canthi.


Platelet fluctuations of the patient within one and a half years (13-Feb-2019-26-Aug-2020) after admission.


Orthopantomograph showing a well-defined, multilocular, mixed radiolucency, roughly 6 cm x 5 cm in size, extending from 21 to 26 with multiple pebble-like ill-defined radiopacities (black arrows).


Paranasal sinus view showing a diffused radiopacity obliterating the left maxillary sinus.


Axial computed tomography showing heterogeneous, soft tissue expansile mass in the left maxillary cuspid region. Destruction of the inner and outer cortical plates and perforation of the facial wall of the maxillary sinus can be noted.


Coronal computed tomography sections showing extension of the lesion into the left maxillary sinus through the antral floor, causing slight elevation of the orbital floor.


Three-dimensional computed tomography reconstruction of the cranium showing perforation of the maxilla in the region of the left canine fossa below the infra orbital foramen.


Enucleated tumor mass.


Gingival lesion at first evaluation. Note, the mandibular gingival recession bounded between right central incisor and first left premolar.


Radiographic findings. Optical projection tomography: Radiolucency was appreciable between the left mandibular canine and first premolar teeth (arrow).


(a) Computed tomography scan (occlusal view) showing buccal cortical bone loss.


(b) Computed tomography showing buccal cortical bone loss.


(a-d) Surgical excision and reconstruction of the mandible with an iliac crest bone graft.


Radiographic findings 4 years after bone reconstruction.


Axial magnetic resonance imaging with contrast.


Histopathology showed proliferation of undifferentiated cells with nuclear molding, surrounding vessel.


Magnetic resonance imaging axial view T2.


Coronal view T2.


Histopathology showed hypocellular areas with nodular fashion (Pale islands).


A: Case 1, induction therapy with 6 doses of eculizumab. Serum creatinine and thrombocytes from admission to last follow-up (week 211). Breast-conserving surgery was performed 7 weeks after withdrawal of eculizumab, followed by radiation therapy 3 months later. TPE = therapeutic plasma exchange; CVVHD = continuous veno-venous hemodialysis; HD = hemodialysis.


B: Case 2, induction therapy with 8 doses of eculizumab. Serum creatinine and thrombocytes from admission to last-follow up (week 42). FFP = fresh frozen plasma.


Serum protein electrophoresis revealed M spike.


Baseline.


One-month after follow-up.


Incisional biopsy.


Histopathological picture showing pseudoepitheliomatous hyperplasia.


Histopathological picture showing vasculitis and granulomatous inflammation.


Follow-up after 3 months.


Axial CT with intravenous and gastrointestinal contrast. A large homogeneous retroperitoneal mass encases the superior mesenteric artery (arrow), displaces the stomach (St) and insinuates into the hepatic hilum. L = Liver; K = kidney; C = colon.


Fluorescence in situ hybridization analysis showing no ALK gene rearrangement (x 100).


Gingival enlargement noted on the buccal and palatal of teeth nos. 25 & 27 and included the edentulous ridge between 25 & 27.


Hematoxylin and eosin stain of biopsied tissue showing diffuse infiltrate of large, pleomorphic tumor cells at low magnification (x40).


Hematoxylin and eosin stain of biopsied tissue showing diffuse infiltrate of large, pleomorphic tumor cells at higher magnification (x100).


Immunohistochemical stain of the biopsied tissue showing the tumor cells being positive for the T-cell marker CD3 (brown reaction product) (x40).


Intra-oral clinical aspect. . Swelling of the right maxillary alveolar ridge, expanded to the right hard palate.


Ortopantomography, showing no evidence of any organic lesion in the oral and maxillofacial area.


CT scan. . Assial view showing solid mass in right maxilla causing destruction of the maxillary sinus floor.


Histopathological examination of the sample. . Hematoxylin & eosin 20x revealing "Starry-sky" pattern from pleomorphic, and ,highly apoptotic lymphocytes, and ,macrophages.


Histopathological examination of the sample. EBER 20x
in situ hybridization positive to EBV-encoded RNA.


Superimposed basal cell carcinoma on a leishmaniasis lesion.


Postinduction chemotherapy CT scan. (A) Residual left atrial lesion.


Postinduction chemotherapy CT scan. (B) Resolved middle cranial fossa and orbit lesions.


Family pedigree and germline mutations identified in the index patient. (A) Family pedigree. The index patient is indicated with an arrow, and the circle filled with black color denotes endometrial cancer.


Family pedigree and germline mutations identified in the index patient. (B) Visualized sequencing data shows the BRCA1 variant.


Family pedigree and germline mutations identified in the index patient. MSH2 exons coverage depth analysis in the index patient.


Family pedigree and germline mutations identified in the index patient. And another sample with the same batch.


CT-PET abnormal 18-FDG uptake on right ventricle thickening 3 months (SUV 4.9, DS 4).


18 months (SUV 5 - DS 4). After ASCT.


(D) Short tau inversion recovery (STIR) T2 black blood image in short axis on the cardiac base.


(E) Steady-state free precession (SSFP) balance image with T2/T1 weighting in short axis on the cardiac base.


Cardiac MRI images of June 2019 (from D to F) show the persistence of the right ventricle anterior wall thickening (14x56 mm). (F) IR TSET1 image for evaluation of myocardial late enhancement in short axis on the cardiac base.


Patient 1. PET/CT in 12/12 (left, prior to vemurafenib) showed innumerable intensely FDG avid lymph nodes and soft tissue deposits scattered throughout the body which developed during her course of ipilimumab by 2 cycles.


Patient 1. PET/CT in 2/13 (right, after starting vemurafenib and completion of the ipilimumab course) showed the previously described intensely FDG avid metastases had entirely resolved. The vemurafenib was weaned and completely stopped by 12/13. She has remained in complete remission to date off all therapy.


Vitiligo of right arm in Patient 1. The photo shows patchy depigmentation of skin after the patient was treated with vemurafenib but this process had actually started after completion of high dose IL-2.


Patient 2. PET/CT on 3/13 (left, prior to vemurafenib) showed intensely FDG avid lymph nodes and soft tissue deposits post ipilimumab.


Patient 2. PET/CT on 6/13 (right, after vemurafenib) showed the previously described intensely FDG avid lymph nodes and nodules had entirely resolved. The vemurafenib was gradually weaned and stopped by 3/14. She has remained in complete remission to date off therapy.


Patient 3. PET/CT in August 2013 (left, prior to BRAF inhibitor therapy) showed intensely FDG avid lymph nodes post ipilimumab which were biopsy confirmed metastatic melanoma.


Patient 3. PET/CT in November 2013(right, after trametinib) showed the previously described intensely FDG avid lymph nodes and nodules had entirely resolved. The skin nodules on his scalp also resolved. The trametinib was gradually weaned and stopped by 5/14. He has remained in complete remission to date off therapy.


mTPE effluent after blood leak. . Abbreviation: mTPE, membrane based therapeutic plasma exchange.


Heavily hemolyzed effluent on day 1 of cTPE. . Abbreviation: cTPE, centrifuge based therapeutic plasma exchange.


Biochemical parameters. . Abbreviations: D, day; eGFR, estimated glomerular filtration rate; LDH, lactate dehydrogenase.


Mechanism of action of rFVIIa.


Neck lymph node (LN) shows metastatic extremely well differentiated papillary thyroid carcinoma (EWD-PTC) E stain, x12.5.


Inset x400) with focal positivity of CK19. X400) in the first metastatic lesion.


The left thyroid shows follicular variant papillary thyroid carcinoma (FVPTC) without capsular (arrow) invasion E stain, x40.


Loss of CD56. X40) in second episode.


The LN also shows metastatic EWD-PTC E stain, x12.5.


Inset x400) with focal positivity of CK19. X400).


Neck lymph node (LN) shows metastatic extremely well differentiated papillary thyroid carcinoma (EWD-PTC) E stain, x12.5, and . The left thyroid shows follicular variant papillary thyroid carcinoma (FVPTC) without capsular (arrow) invasion E stain, x40, and . The LN also shows metastatic EWD-PTC E stain, x12.5, and . CD56. X400) in the second metastatic lesion. The skull lesion shows metastatic FVPTC E stain, x100.


The skull lesion shows metastatic FVPTC E stain, x100.


CD56. X400).


Histological findings in the kidney biopsy of the patient. PAS staining.


Histological findings in the kidney biopsy of the patient. IgG staining.


Histological findings in the kidney biopsy of the patient. Electron microscopy confirm the diagnosis of minimal change disease with no IgG positivity, no electron dense deposits, and diffuse loss of podocyte foot processes.


Histological findings in the kidney biopsy of the patient. (D) Only very few CD20 positive cells were detectable, mostly in the area of tubular atrophy and interstitial fibrosis.


MRI scans showed a well-defined oval mass located in cervix, which destroyed the stroma The mass showed slight hyperintensity on T2-weighted MR images.


Isointensity on T1-weighted MR images.


(C) The ADC map showed low ADCs.


The mass showed slight hyperintensity on T2-weighted MR images.


(F) Sagittal contrast-enhanced MR image showed mild to moderate heterogeneous enhancement of the lesion, presenting rim-enhancement.


Histological and immunohistochemical features of SEP. (A) Hematoxylin-eosin staining shows that the monoclonal well-differentiated plasma cells are diffusely distributed and consistent in size. [Original magnifications:. 200x.


Histological and immunohistochemical features of SEP. (B-D) Immunohistochemical staining presented CD38(+), CD138(+), Kappa (+). [Original magnifications:. 200x.


Histological and immunohistochemical features of SEP. (B-D) Immunohistochemical staining presented CD38(+), CD138(+), Kappa (+). 400x.


Anterior-posterior supine chest film.


(A)
Chlamydia psittaci detection in bronchoalveolar lavage fluid (BALF) using metagenomic next-generation sequencing (mNGS) on October 25, 2020.


Kidney, ureter, and renal vessels of living donor (Mother). Volume-rendered (VR) image showing normal kidneys, and ,urinary tracts bilaterally.


Kidney, ureter, and renal vessels of living donor (Mother). Maximum intensity of projection (MIP) showing bilateral normal renal arteries originating from aorta, and ,branching well into the renal parenchyma.


Kidney, ureter, and renal vessels of living donor (Mother). Right kidney shows uniform hypoattenuated subcapsular rim of cortex (Axial Image).


Kidney, ureter, and renal vessels of living donor (Mother). Uniform hypoattenuated subcapsular rim of cortex (Coronal Image). Both C and D favor feature of renal cortical necrosis in kidney donor.


Major clinical features of the patient. (A) Corneal leucoma in both eyes, with no visible pupils and a small left eyeball.


Major clinical features of the patient. (B) Nail dystrophy (right index finger).


Major clinical features of the patient. (C-E) Bilateral absence of the patella.


Major clinical features of the patient. (F) The full body photo of the patient.


Abdominal computed tomographic scan revealing a large, right-sided retroperitoneal mass (red arrow).


Hematoxylin and eosin staining showing blood filled dilated vascular spaces with single lining of endothelial cells (red arrow) and adjacent normal adrenal tissues (yellow arrow). Original magnification: x200.


Selected computed tomography images of the spine. Axial.


Selected computed tomography images of the spine. Sagittal. Views demonstrate the left paraspinal soft-tissue mass (*) with an area of calcification that is extended from the level of T12/L1 down to the L4 level vertebra. Note the bone erosion changes in the lamina at the axial plane and the extension into the L1/L2 left neural foramina (arrows).


A; Peripheral blood shows marked leukocytosis with numerous blasts and promyelocytes, dyspoietic granulocytes with nuclear hypolobation and hypogranularity, and dyspoietic erythroid precursors.


B; Bone marrow core biopsy is hypercellular for age (80%). Maturing granulopoiesis and erythropoiesis are replaced by sheets of immature cells. Megakaryocytes are decreased and have atypical morphology.


C; Bone marrow aspirate consists of blasts which are intermediate in size with fine chromatin, prominent nucleoli and scant basophilic cytoplasm. A few dyspoietic maturing granulocytes and atypical megakaryocytes are present.


Partial karyograms of a 46,XY,+ 1,der(1;21)(p10 or q10;q10) karyotype, a 46,XY,+ 1,del(1)(p12) karyotype, and 46,XY,+ 1,der(1;14)(p10 or q10;q10).


F; Fusion sites of recipient chromosomes of 149 jumping translocations of 1q in 48 myeloid neoplasm patients (including our patient).


G; A possible multi-stage process for the development and formation of 1q JTs in our patient.


18)(q10) karyotype. E Whole-genome SNP microarray shows mosaic gain of chromosome 1 from 1p11 to 1qter regions and mosaic gain of chromosome 18q.


Picture showing the patient with swelling at the superolateral angle of the left orbit.


Computed Tomography scan showing a well circumscribed and homogeneous left supraconal tumor.


Gross picture of the excised mass.


Low magnification showing a lesion with fascicular architecure in a predominantly fibrous background (haematoxylin & eosin stain, x 50).


Higher magnification showing the residual glands that are encircled by the proliferation (haematoxylin & eosin stain, x 200).


Higher magnification showing a stroma infiltrated by numerous inflammatory cells composed of lymphocytes, plasma cells and eosinophils (haematoxylin & eosin stain, x400).


Immunohistochemical staining revealed the expression of smooth muscle actin.


ALK. By the neoplastic cells.


Keratin highlights the residual glands (c).


Ki-67 immunostaining showed a low proliferation index (d).


Hyperintense lesion with perifocal edema left occipital in fluid-suppressed T2 MRI technique (Fluid-attenuated inversion recovery (FLAIR) sequence).


Hyperintense lesions in medulla oblongata and in cervical and upper thoracic spinal cord in contrast enhanced, fat suppressed T1 MRI technique.


Non-contrast CT kidneys showing bilateral nephrolithiasis.


CT angiogram, axial view: Yellow arrows pointing at emboli (grey area) within pulmonary arteries.


Digital subtraction angiogram of the distal superficial femoral artery and popliteal artery. Red arrows point at areas of filling defects (contrast appears dark).


(A) Fundus photography revealed a whitish-yellow inflammatory lesion near an atrophic, pigmented retinochoroidal scar located in the superotemporal quadrant.


(B) Spectral domain optical coherence tomography showed increased reflectivity from the inner retinal layer, retinal thickening and choroidal shadowing. Focal posterior hyaloid thickening and detachment were also observed (arrow).


(C) Hyperreflectivity, thinning of the neurosensory retina and a disorganized retinal pigment epithelium layer were observed.


(A) The lesion resolved and had a scar-like appearance.


(B) Spectral domain optical coherence tomography showed thinning of the retina, loss of normal striations, and a disorganized retinal pigment epithelium layer in addition to posterior hyaloid detachment (arrow).


Chest X-ray demonstrating bilateral pulmonary infiltrates caused by pneumocystis pneumonia.


Grocott-Gomori's methenamine silver stain of sputum specimen showing "cup shaped" Pneumocystis jirovecii cysts in small aggregates.


Pedigree of the affected family. Arrow indicates the patient of discussion.


Bone marrow biopsy showing increased fat and decreased cellularity with relative paucity of normal B-cells. A; H&E (100x).


Bone marrow biopsy showing increased fat and decreased cellularity with relative paucity of normal B-cells. B; IHC CD138 (200x), occasional plasmacytoid reactive cells.


Bone marrow biopsy showing increased fat and decreased cellularity with relative paucity of normal B-cells. C; IHC CD3 (200x), numerous small immunoreactive cells.


Bone marrow biopsy showing increased fat and decreased cellularity with relative paucity of normal B-cells. D; IHC CD20 (200x), scattered small immunoreactive cells.


Microscopic findings of the resected appendix showed tumour cells infiltration into the muscularis propriae, with two distinct components identified (H&E, 40x).


First component: nests of tumour cells exhibiting uniform, round nuclei with salt and pepper chromatin (arrow head). Second component: goblet cells displaying univacuolated cytoplasm and peripherally compressed nuclei (arrow) (H&E, 200x).


Immunohistochemical findings revealed both components are positive for synaptophysin (A).


However, only the goblet cells are positive for CK20 (B) (400x).


Photomicrography of the lymph node showing partial cytoplasmic positivity for ZAP-70 of the neoplastic cells with moderate or strong intensity (Immunohistochemistry-Ventana. 2F3.2, 600X).


Small lymphoid cells were positive for CD20 (x200).


Computer tomography scan of the abdomen showing lymphadenopathies in abdomen of the patient.


Summary protocol of medication treatment and CD19CAR structure. (A) Summary protocol of the patient's treatment.


Summary protocol of medication treatment and CD19CAR structure. (B) The schematic diagram of pCDH-CD19-CAR.


Changes of total CART percent after CAR-T treatment. (A) The proportion of CAR-T cells in CD3 positive T cells was detected by flow cytometry in PB.


Changes of total CART percent after CAR-T treatment. (B) The proportion of CAR-T cells in CD3 positive T cells was detected by flow cytometry in CSF.


At first admission, Tc99 DMSA scan shows upper part of right kidney has not taken radiotracer, left kidney shows homogenous uptake without scar or acute pyelonephritis. Technetium 99 dimercaptosuccinic acid: TC99 DMSA.


Voiding cystourethrography shows no vesicoureteral reflux, mild trabeculation in bladder wall and vertebral deviation against affected side can be seen.


Bilateral absent radius, radial club hand, and flexion against the palm.


Bilateral absent radius, radial club hand, and flexion against the palm. . Note: Note thumb of opposite hand is visible in the photo.


X-ray of upper limb showing absence of radius bone in the patient.


Postoperative immunological pathology findings confirmed the lesion to be non-small cell lung cancer (adenocarcinoma). (A) Hematoxylin and eosin staining.


Postoperative immunological pathology findings confirmed the lesion to be non-small cell lung cancer (adenocarcinoma). Immunological images showing the lesion to be. Thyroid transcription factor 1-positive.


Postoperative immunological pathology findings confirmed the lesion to be non-small cell lung cancer (adenocarcinoma). Cytokeratin (CK) 88-positive.


Postoperative immunological pathology findings confirmed the lesion to be non-small cell lung cancer (adenocarcinoma). CK-positive. All images: Magnification, x200.


(A and B) PET-CT scan showed an abnormal mass at the level of T9 and the left upper lobe of the lung.


Twenty-four months after treatment, PET-CT scan showed inactivation of the neoplasm in the left upper lobe, and ,T9 vertebra, and . A decrease in the left upper lobe mass in the short axis. PET-CT, positron emission tomography-computed tomography.


Twenty-four months after treatment, PET-CT scan showed inactivation of the neoplasm in the left upper lobe, and ,T9 vertebra.


Fundus photograph and fluorescein angiography after surgery. . Notes: (A) Fundus photograph at 20 hours after surgery showing a cherry-red spot and multifocal retinitis with sheathing of the retinal arteries.


Fundus photograph and fluorescein angiography after surgery. (B) Fluorescein angiography at 20 hours after surgery showing evidence of the plaques on the walls of blood vessels, the periarterial exudates, and obstruction to blood flow.


Fundus photograph and fluorescein angiography after surgery. (C) Fundus photograph at 2 months after surgery showing disappearance of the cherry-red spot.


Spinal magnetic resonance imaging performed on the initial presentation demonstrating an increased signal intensity, which was more pronounced in the gray matter, on a T2-weighted image at the level of Th3. Sagittal T2-weighted image.


Axial T2-weighted image at the level of Th3).


EEG showing bilateral frontoparietal polyspikes and spike-and-wave discharges, predominantly on the right hemisphere.


Brain MRI Flair sequences showing new confluent subcortical white matter lesions compatible with inflammation (red arrows) (A, B).


Clinical course timeline during the first 15 months of follow-up, with three clinical relapses and subsequent improvement after immunotherapy administration. IVIG, intravenous immunoglobulins; mRS, modified Rankin score; RTX, rituximab.


FDG-PET before treatment revealed increased uptake in the mediastinal lesion and right supraclavicular lymph node.


Large polypoidal growth measuring around 10 x 6 cm involving the vulva including bilateral labia majora, clitoris, labia minora, and anterior fourchette.


A few grouped papules of similar morphology over the left upper thigh.


Periorbital purpura; skin changes in this patient.


Treatment and coagulogram at previous hospital.


Bone marrow aspirate smear.


FISH analyses with chromosomes 4 and 22 probes. . Notes: Image showing the results of FISH on a metaphase spread, with painting probes for chromosomes 4 (orange) and 22 (aqua). The yellow arrows indicate normal chromosome 4 (orange - in the upper), residual chromosome 4 (orange - in the middle) and chromosome 22 (aqua); the red arrow indicates derivative chromosome 4 (orange + aqua). . Abbreviation: FISH, fluorescence in situ hybridization.


Brain MRI in the 7th . FLAIR and DWI show a mass involving the right basal ganglia and thalamus (a, b).


Brain MRI in the 7th . The mass was clearly enhanced (c).


9th. Week after admission. Two weeks later, the mass had enlarged (d-f).


Humphrey's Visual Field Analyzer report of 30-2 SITA fast testing strategy to show the enlargement of blind spot and resolution on treatment in the left eye.