Humphrey's Visual Field Analyzer report of 30-2 SITA fast testing strategy to show the enlargement of blind spot and resolution on treatment in the right eye.


Fundus photograph showing bilateral disc edema and resolution following treatment with Vitamin B12.


Optical coherence tomography section through the disc demonstrating the peripapillary edema.


Bone marrow aspiration smear shows: (a) Macrophages with engulfed erythroid cells and lymphocytes (hemophagocytosis).


(b) Megakaryocyte with engulfed Leishman-Donovan bodies (Giemsa, x1000).


CT of the chest with contrast medium, arterial phase, coronal view. Irregular, thickened peribronchium with narrowing of the lumen of segmental and subsegmental bronchi, fibrosis (marked with arrows) with compensatory dilation of the bronchial lumen (bronchiectasis), signs of bronchiolitis in PS10 and LS 10, irregular nodules in LS9 and LS10, a trace of fluid in the pericardium, enlarged right upper paratracheal, below carina, paraaortic, perivascular lymph nodes.


CT of the abdomen with contrast medium, arterial phase, axial, and coronal views. Hypodense foci in the II and VIII segments of the liver, enlarged spleen, ca. 14 cm long with nonhomogenous attenuation, hypoplastic left kidney, lymphadenopathy of lymph nodes in the regions of the head of the pancreas, portal vein, right renal hilum, inferior vena cava (marked with arrows), and retroperitoneal, iliac and aortic lymph nodes, forming a mass 8.5 cm long.


Preoperative imaging of the glomangiopericytoma. Axial T1 magnetic resonance imaging with gadolinium.


Preoperative imaging of the glomangiopericytoma. T1 without gadolinium.


Preoperative imaging of the glomangiopericytoma. Flair.


Preoperative imaging of the glomangiopericytoma. T2.


Preoperative imaging of the glomangiopericytoma. Sagittal.


Preoperative imaging of the glomangiopericytoma. Coronal. T1 with gadolinium depicting the tumor in the left cavernous sinus simulating an intracavernous meningioma.


Preoperative imaging of the glomangiopericytoma. Axial.


Preoperative imaging of the glomangiopericytoma. Coronal. Computed tomography angiography demonstrating low vascular flow to the tumor in the left cavernous sinus.


Immediate postoperative imaging after endoscopic tumor debulking. Axial.


Immediate postoperative imaging after endoscopic tumor debulking. Sagittal.


Immediate postoperative imaging after endoscopic tumor debulking. Coronal. T1 magnetic resonance imaging with gadolinium depicting residual tumor in the left cavernous sinus with expected postoperative changes.


Postoperative imaging 5 months after tumor debulking. Axial.


Postoperative imaging 5 months after tumor debulking. Sagittal. T1 magnetic resonance imaging with gadolinium.


Postoperative imaging 5 months after tumor debulking. Coronal T2. Showing stable tumor with no interval growth/progression.


vWF and Factor VIII response to intravenous immunoglobulin (IVIg) therapy.


Representative pictures of gastric cardia mass. Each immunostain or tissue stain is indicated within each picture. Abbreviations: Hematoxilin and Eosin stain (H&E). Myeloperoxidase immunostain (MPO).


Some specimens at first cytoreductive surgery. . Notes:. Metastases located between spleen, and ,descending colon.


Some specimens at first cytoreductive surgery. Omentum.


Postoperative pathology proved the tumor was a MOGCT with immature teratoma (G2), small amount of YST and embryonal carcinoma. . Notes:. Immature teratoma component (HE, 100x).


Postoperative pathology proved the tumor was a MOGCT with immature teratoma (G2), small amount of YST and embryonal carcinoma. YST, and ,embryonal carcinoma component (HE, 400x).


Postoperative pathology proved the tumor was a MOGCT with immature teratoma (G2), small amount of YST and embryonal carcinoma. AFP immunostain diffusely positive in YST component (400x).


Postoperative pathology proved the tumor was a MOGCT with immature teratoma (G2), small amount of YST and embryonal carcinoma. SALL-4 positive in YST, and ,embryonal carcinoma component.


Postoperative pathology proved the tumor was a MOGCT with immature teratoma (G2), small amount of YST and embryonal carcinoma. SOX2 positive in embryonal carcinoma.


Postoperative pathology proved the tumor was a MOGCT with immature teratoma (G2), small amount of YST and embryonal carcinoma. AE1/AE3 positive in YST and embryonal carcinoma component. . Abbreviations: MOGCT, malignant ovarian germ cell tumor; YST, yolk sac tumor.


The result of comprehensive genomic profiling revealed an EGFR somatic mutation (p. L858R).


A 56-year-old woman presents to the emergency department for a left painless dorsolumbar fluctuating mass which was progressively growing over 3 months. Ultrasonography was the first imaging study obtained. A long-axis view of the left kidney shows subcutaneous and parietal multiloculated heterogeneous hypoechoic collections, compatible with abscess adjacent to the left kidney (red arrow). Moderate left hydronephrosis is also present (white arrowheads).


Ultrasonography and computed tomography showed an infected urinoma with left pelvicalyceal rupture, secondary to an obstructive calculus with nephrocutaneous fistula. The calculus was endoscopically removed and a left ureteral stent was placed, with an antibiotic coverage. The clinical condition of the patient did not improve after antibiotic therapy. A planar image from 99 mTc-dimercaptosuccinic acid cortical renal scintigraphy was performed to estimate the remaining left kidney function and shows the uptake percentages of the radionuclide by the normal right kidney (Roi 1) and by the nonfunctional left kidney (Roi 2), estimated to 4%. The miniscule remaining left renal function leads to the decision to perform total left nephrectomy.


This patient undergoes a left nephrectomy for infected urinoma with nonfunctional kidney, secondary to an obstructive calculus, calyceal rupture, and nephrocutaneous fistula. A picture of the pathological specimen of the left ureter at the level of the obstruction shows a left ureteral obstruction by a conglomerate of microstones (white arrowheads). The proximal ureter (white arrow) is surrounded by an intense chronic fibroinflammatory process while the distal ureter is normal (red arrow).


Medical image.


T1 contrast showing homogenously hypointense lesion with minimal patchy enhancement in cerebellum. T2 fluid attenuated inversion recovery showing homogenously hypertintense lesion in cerebellum.


His appearance from the side.


His appearance from the front.


(a) The core biopsy with half of the cortex showing acute cortical necrosis (arrow) (PAS, x40).


(b) Illustrates the thrombotic microangiopathy in one of the vessels with total occlusion of the lumen (arrow) (PAS, x400).


(a) Mesangial expansion and mild mesangial cellularity (H and E, x400). (b) Direct immunofluorescence reveals granular positivity in the mesangium with immunoglobulin A (3.


Biopsy of the left adrenal mass: (a and b) Photomicrographs showing features of nonHodgkin's lymphoma with diffuse architecture composed of intermediate to large atypical lymphoid cells (H and E, x4 and x40 respectively). (c) Immunohistochemistry is positive for leukocyte common antigen (x40). (d) CD-3 (x40). (e) CD-56 (x40). Immunohistochemistry was negative for (f) CD-20 (x40). (g) CD-4 (x40). (h) CD-8 (x40).


Representative features of endoscopic findings of the small-bowel enteropathy-associated T-cell lymphoma. (A) Double-balloon-enteroscopy (DBE) showed diffuse fine granularity and edematous mucosa with circumferential shallow ulcerations on the ileum.


Representative features of endoscopic findings of the small-bowel enteropathy-associated T-cell lymphoma. (B) DBE revealed diffuse mucosal thickening and nodularity with multiple shallow semicircular ulcerations from the mid to distal jejunum.


Representative features of endoscopic findings of the small-bowel enteropathy-associated T-cell lymphoma. In another cases, shallow ulcerations encircled the diffusely swollen mucosa of the jejunum.


Representative features of endoscopic findings of the small-bowel enteropathy-associated T-cell lymphoma.innumerable fine granular elevations (velvety or sand-like mucosa) were observed on the mid to distal jejunum.


QLQ-C30 Functional scales.


Combined symptoms score.


MPN-SAF.


Pathology of placenta biopsy showing caseating tuberculous granulomas. (A) Caseous necrosis in a placenta (H&E staining, 200x). A; Langhans multinucleated giant cells was found at the edge of the nodule (arrow) (H&E staining, 200x).


Pathology of placenta biopsy showing caseating tuberculous granulomas. (B) Granuloma was found in the placenta, which was comprised of proliferative epithelioid cells.


Pathology of placenta biopsy showing caseating tuberculous granulomas. (C) CD68 immunohistochemical staining highlighted the proliferative epithelioid cells as well as the Langhans multinucleated giant cell (CD68 immunostaining, 200x).


Pathology of placenta biopsy showing caseating tuberculous granulomas. (D) The proliferative epithelioid cells and the Langhans multinucleated giant cell were negative for PLAP, while the placental syncytiotrophoblast cells were positive for PLAP (PLAP immunostaining, 200x).


Treatment and observation during hospitalization. Picture. Showing body temperature, and ,treatment.


Treatment and observation during hospitalization. Picture. Showing white blood cell count, and ,platelet count.


Treatment and observation during hospitalization. Picture. Showing serum fibrinogen, and ,ferritin.


Treatment and observation during hospitalization. Picture. Showing C-reactive protein and interleukin-6, during hospitalization.


Radiographic images of the patient's chest on admission. Chest radiograph.


Radiographic images of the patient's chest on admission. And chest computed tomography.


The restriction fragment length polymorphism pattern of hsp65 amplicon fom Mycobacterium branderi. Lane (1) 100 bp deoxyribonucleic acid size marker, lane (2) fragment digested with HaeIII, lane (3) fragment digested with BsteII.


(A) Contrast enhanced CT on day +70 after HSCT presented right cervical lymph nodes enlargement with central necrosis.


(B) Highresolution chest CT revealed old pulmonary scar lesions with pleural thickening in the right upper lobe.


Cervical lymph node biopsy wound on day +90 with purulent suppuration.


Haematoxylin and eosin stain of the lymph node showed granuloma formations with necrosis.


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. Immunohistochemical staining of H&E . H&Ex100, inset: H&Ex400.


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. Negative for CD20 . . X200).


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. Positive for CD3 ,. . X200).


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. CD21 ,. . X200).


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. CD10 ,. . X200).


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. Bcl-6 ,. . X200).


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. CD4 ,. . X200).


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. PD-1 . X200).


Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. Ki67 ,. . X200).


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. Immunohistochemical staining of H&E . H&Ex100, inset: H&Ex400.


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. Positive for CD20 ,. . X200.


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. Negative for CD3 ,. . X200.


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. MUM1 ,. . X200.


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. CD10 ,. . X200.


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. Bcl-6 ,. . X200.


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. EBER . . X200.


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. PD-1 . X200.


Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. Ki67 ,. . X100).


Low-power view showing the follicular arrangement of cells and the overall basophilic staining quality (H&E, x100).


High power of the follicle and pleomorphic cells with prominent nucleoli (H&E, x400).


High-power view showing pleomorphic cells and abundant mitoses (H&E, x400).


Initial CT imaging findings. Subdural hematoma with obviously shifted midline structure to the contralateral side.


CT imaging findings immediately after the first surgery. Complete removal of the hematoma.


CT imaging findings after first and second surgeries. A large subcutaneous hematoma again appears with midline deviation on postoperative day 1 after the first surgery (a).


CT imaging findings after first and second surgeries. Complete removal of the hematoma (b).


CT imaging findings after cranioplasty. A small amount of air is the sole abnormal finding immediately after cranioplasty (a).


CT imaging findings after cranioplasty. Epidural hematoma is evident under artificial bone at 22 hours after cranioplasty (b).


Histopathologic specimen. (A) H&E staining, 100x.


Histopathologic specimen. (B) Ki67 staining, 100x.


Histopathologic specimen. (C) p16 staining, 100x.


Histopathologic specimen. (D) p63 staining, 100x.


Mass of 37x35 mm detected in the left inguinal region on pelvic MRI. (A) Low signal intensity of approximately 37x35 mm detected in the left inguinal region on T1-weighted imaging (arrow).


Mass of 37x35 mm detected in the left inguinal region on pelvic MRI. (B) High signal intensity of approximately 37x35 mm detected in the left inguinal region on T2-weighted imaging (arrow).


Mass of 33x33 mm detected in the left inguinal region on pelvic MRI. (A) Low signal intensity of approximately 33x33 mm detected in the left inguinal region on T1-weighted imaging (arrow).


Mass of 33x33 mm detected in the left inguinal region on pelvic MRI. (B) High signal intensity of approximately 33x33 mm detected in the left inguinal region on T2-weighted imaging (arrow).


A computed tomography image, with intravenous contrast. . Note: The mass in the left renal middle pole is shown (white arrows).


Color ultrasound images of the space-occupying lesion in the left kidney. . Notes: (A) A hyperechoic mass was detected in the mid pole of the left kidney, with a definite boundary and an irregular shape.


Color ultrasound images of the space-occupying lesion in the left kidney. (B) A rod-like blood signal was detected in the mass, and renal perfusion was normal.


Immunohistochemistry. . Notes: (A) Cytokeratin 7 was strongly positively expressed in the cytoplasm of the papillary RCC cells (magnification, x400).


Immunohistochemistry. (B) Alpha-methylacyl coenzyme A racemase displayed weak positive expression in the cytoplasm of papillary RCC cells (magnification, x400).


Immunohistochemistry. (C) Cluster of differentiation 10 was slightly positively expressed in the papillary RCC cells (magnification, x400).


Immunohistochemistry. (D) WT1 exhibited strong positive expression in the WT nuclei (magnification, x400). . Abbreviations: RCC, renal cell carcinoma; WT, Wilms' tumor; WT1, Wilms tumor gene 1.


CT scan of the abdomen demonstrates hepatomegaly and splenomegaly.


Bone marrow aspirate. High power view. Hypercellular for age (80%). Demonstrates involvement with T-cell lymphoma and hemophagocytes.


Bone marrow biopsy. Low power view. CD3 immunohistochemical staining consistent with lymphoma cells. Immunophenotyping was positive for CD16, and CD57 and was double negative for CD4 and 8.


Bone marrow biopsy. The IHC stain was also positive for KP1 (CD68), highlighting the nuclei of engulfed cells within macrophages.


Liver biopsy. High power view. Sinusoidal infiltration of hepatic sinusoids by lymphocytes.


Photograph showing the gross specimen of giant adrenal myelolipoma with hemorrhage. The lipomatous component is seen in the periphery (black arrow).


Microphotograph showing admixture of adipose tissue with hematopoietic elements. The preserved adrenal tissue is seen in the upper part of the tumor. (Hematoxylin and eosin stain, x100 magnification). Inset shows high power view of a megakaryocyte in a background of myeloid and erythroid cells. (Hematoxylin and eosin stain, x400 magnification). Megakaryocytes are highlighted with black arrows.


Intraoperative finding showing enlarged bilateral ovaries, arrow pointing to enlarged left fallopian tube.


Total abdominal hysterectomy with bilateral salpingo-oophorectomy specimen, arrow pointing to enlarged left fallopian tube.


Cut section showing predominantly solid, homogenous, gray-white ovary with few small cysts, and ,areas of hemorrhage.


On low power microscopy, ovary shows diffuse dense infiltrate of monomorphic neoplastic lymphoid cells with intact capsule (arrow).


Low power microscopy of the left fallopian tube showing diffuse dense infiltrate of monomorphic neoplastic lymphoid cells consisting of medium-sized cells with round to oval nuclei, finely dispersed chromatin, and ,single to multiple small nucleoli.


Immunohistochemistry showing tumor cells were diffusely, and ,strongly positive for Tdt.


Immunohistochemistry showing tumor cells were negative for B-cell marker CD-20.


A, B. Morphology analysis of the BM cells reveals a population of 27% medium sized blast cells that present irregular nuclear outlines, fine chromatin and reduced agranular basophilic cytoplasm.


Flow cytometry was performed on the BM cells. The blastic plasmacytoid dendritic cell population is highlighted in orange. The blasts were intermediate positive for CD45.


Flow cytometry was performed on the BM cells. The blastic plasmacytoid dendritic cell population is highlighted in orange. ; partially positive for CD117 and CD7.


Flow cytometry was performed on the BM cells. The blastic plasmacytoid dendritic cell population is highlighted in orange. ; positive for CD4, CD36, CD56, CD123, HLA-DR and NG2.


Flow cytometry was performed on the BM cells. The blastic plasmacytoid dendritic cell population is highlighted in orange. ; positive for CD4, CD36, CD56, CD123, HLA-DR and NG2. And negative for CD94.


Flow cytometry was performed on the BM cells. The blastic plasmacytoid dendritic cell population is highlighted in orange. , CD34.


Flow cytometry was performed on the BM cells. The blastic plasmacytoid dendritic cell population is highlighted in orange. , cyCD3 and cyCD79a.


Flow cytometry was performed on the BM cells. The blastic plasmacytoid dendritic cell population is highlighted in orange. And cyMPO.


Swelling of right vestibule and paalatal of maxilla.


The Biopsy of buccal vestibule.


Results of MSCT, macro and microscopy. (A) MSCT of the abdominal cavity with contrast. Neoplasm in the middle and lower segments' projection of the right kidney, in size of 147 x 190 x 188 mm, which unevenly accumulated a contrast agent (from 35 units N. To 50-90 units N. ). No signs of invasion of the vascular pedicle were noted.


Results of MSCT, macro and microscopy. (B) Back table examination. Right kidney with a tumor measuring 300 x 253 x 150 mm (4308 g).


Results of MSCT, macro and microscopy. (C) In the section, the right kidney is completely replaced by yellow-brown tumor masses.


Results of MSCT, macro and microscopy. (D) Hematoxylin and eosin (H&E)-stained slide. The tumor is represented by interwoven bundles of stretched cells with enlarged hyperchromic nuclei, foci of necrosis and hemorrhages. Mitoses are also observed (original magnification x100).


Results of MSCT, macro and microscopy. (E) Immunohistochemical reaction with antibodies to SMA (original magnification x200).


Results of MSCT, macro and microscopy. (F) Immunohistochemical reaction with antibodies to desmin (original magnification x200).


Histological examination of the bone marrow. (A) The bone marrow aspiration shows an excess of platelets (white arrow) and a lymphoplasmacytoid lymphocyte (black arrow), which has a shoe shaped cell with pale blue cytoplasm and an irregular nucleus (giemsa staining; x1000).


Histological examination of the bone marrow. (B) A lymphoplasmacytoid lymphocyte (black arrow) with pale blue cytoplasm and an eccentric nucleus (giemsa staining; x1000).


Histological examination of the bone marrow. (C) The bone marrow trephine shows increased numbers of lymphocytes and an excess of mature megakaryocytes with hyperlobulated nuclei (black arrow; hematoxylin and eosin staining; x400).


Computed tomography scan showing a 2 cm mass (arrow) in the pancreaticoduodenal groove near D1-D2.


H + E stain of the well-differentiated pancreatic neuroendocrine tumor at 20x power.


H + E stain of liver metastasis at 10x power.


Gastrin stain (+) liver metastasis at 20x power. H+E, hematoxylin and eosin stain.


Preoperative axial.


Coronal.


Sagittal. T1-weighted MRI studies showing a gadolinium enhancing extra-axial mass of the left tentorial incisure.


Temporal lobe edema is seen on the axial T2-weighted MRI studies (d).


Abdominal CT angiography: axillary vein bypass.


Abdominal CT angiography: left ilio-renal shunt.


Operative view: tumor of the inferior vena cava.


Resection of the mass carrying the piece and invaded part of the inferior vena cava.


Magnetic resonance images of the cervical spine demonstrating a well-defined oval intramedullary lesion expanding the spinal cord at C7-Th1. (a) Sagittal T2-weighted-images demonstrating a well-defined hypointense mass causing an important edema above and under it.


Magnetic resonance images of the cervical spine demonstrating a well-defined oval intramedullary lesion expanding the spinal cord at C7-Th1. (b) Homogenous gadolinium enhancement is evident.


Magnetic resonance images of the cervical spine demonstrating a well-defined oval intramedullary lesion expanding the spinal cord at C7-Th1. (c) A predominant anterior location within the spinal cord is observed on axial images after the application of gadolinium.


(a) Immunohistochemistry: Double immunohistochemical staining revealing histiocytes enhanced by CD68 (brown). Lymphocytes enhanced by CD45 antibodies (in red) confirming emperipolesis.


(b) CD68 immunohistochemical staining enhancing the histiocyte population.


Vasopressor and fluid resuscitation support needed to maintain a minimum mean arterial pressure (MAP) of 40 mmHg. The kinetics of the mean arterial blood pressure as determined by non-invasive blood pressure (NIBP) "cuff" (blue line) and continuous invasive blood pressure (CIBP) "arterial line" (red line) (A).


Vasopressor and fluid resuscitation support needed to maintain a minimum mean arterial pressure (MAP) of 40 mmHg. The dosing of vasopressors, expressed as vasopressor potency, against time (B). Given their higher biologic activity, vasopressor potency for epinephrine (red line) and norepinephrine (green line) were calculated as the dose (mug/kg/min) x 100, whereas the vasopressor potency of dobutamine (blue line) was calculated as simply the dose of dobutamine (microgram per kilogram per minute).


Vasopressor and fluid resuscitation support needed to maintain a minimum mean arterial pressure (MAP) of 40 mmHg. Ongoing fluid resuscitation using both colloid (5% albumin in NS) and blood products (including packed red blood cells and fresh frozen plasma) needed to maintain a minimum MAP of 40 mmHg (dotted line) (C).


Endoscopic ultrasound showing 2 periesophageal/perigastric lymph nodes (11.6 mm, 7.2 mm).


Staging CT scan of the abdomen showing thickening of the gastroesophageal junction corresponding to the primary lesion. Arrow indicates the neoplastic lesion at the gastroesophageal junction with a diameter of 10.30 mm (upper panel). Staging PET scan of the abdomen showing hypermetabolism in the corresponding primary lesion. The neoplastic lesion at the gastroesophageal junction demonstrates hypermetabolism (lower panel).


Course after nivolumab treatment. Laboratory data regarding liver function.


Course after nivolumab treatment. Cytokine levels assessed by ELISAs.


Computed tomography scans of the liver on day 8. A) Non-contrast computed tomography revealed oedema of the Gleason sheath.


Computed tomography scans of the liver on day 8. B) Contrast computed tomography revealed neither bile duct obstruction nor liver metastasis progression.


Axial.


Sagittal. T1-weighted magnetic resonance imaging scans revealed a heterogeneous osteolytic mass in the right parietal region.


The lesion intensely enhanced after contrast administration in the axial.


Sagittal. T1-weighted magnetic resonance imaging scans.


Selected axial sections (a-c) of cranial computed tomography scans demonstrating the skull defect with associated large subgaleal and extradural hematoma.


Photomicrograph showing polymorphic infiltrate of Langerhans histiocytes (polygonal cells with kidney-shaped and elongated nuclei had longitudinal groove) admixed with many eosinophils.


Six-year follow computed tomography scan without.


With contrast. Demonstrating no recurrence and spontaneous bone formation and closure of the skull defect.


Large anaplastic cells with prominent nucleoli admixed with histiocytes and many eosinophils (A&B) show diffuse positive immunoreaction to Leukocyte common Antigen (LCA) (C).


(a) A chest X-ray conducted in the emergency department revealed cardiomegaly and patchy airspace consolidations with infiltrations in the right lung field.


(b) One year later, another chest X-ray revealed normal heart size without visible airspace consolidations.


Magnetic resonance imaging with contrast demonstrated lobulated masses over lower pole of the right kidney (arrow) and left suprarenal area (arrow).


Case 1 pathological figures. (A) Computed tomography of gastric stump after gastric cancer surgery.


Case 1 pathological figures. (B) Postoperative pathological biopsy result revealed moderately differentiated adenocarcinoma of cardia (Hematoxylin & Eosin staining, x20).


Case 2 pathological figures. (A) Preoperative computed tomography showed a oval nodule in the right breast (arrow).


Case 2 pathological figures. (B) Biopsy revealed breast invasive carcinoma (Hematoxylin & Eosin staining, x20).


Case 3 pathological figures. (A) Preoperative computed tomography showed round ground-glass nodule in the left lower lung (arrow).


Case 3 pathological figures. (B) Pathological biopsy revealed left lung moderately-differentiated adenocarcinoma (Hematoxylin & Eosin staining, x20).


Case 4 pathological figures. (A) Preoperative computed tomography of cervical occupying lesion (arrow).


Case 4 pathological figures. (B) Pathological biopsy result revealed poorly-differentiated squamous cell carcinoma of the cervix (Hematoxylin & Eosin staining, x20).


Case 5 pathological figures. (A) A hypoechoic mass can be seen in the left lobe of the thyroid gland, and a punctate lesion with strong echo was seen (arrow).


Case 5 pathological figures. (B) Thyroid biopsy result revealed papillary carcinoma (Hematoxylin & Eosin staining, x20).


Case 6 pathological figures. (A) The soft tissue mass near the right femur (arrow) at initial diagnosis.


Case 6 pathological figures. (B) After 4 courses of chemotherapy for multiple myeloma, the soft tissue mass near the right femur was significantly larger than that at initial diagnosis.


Case 6 pathological figures. (C) Pathologica biopsy result revealed lymphoma or plasmacytoma at initial diagnosis (Hematoxylin & Eosin staining, x20).


Case 6 pathological figures. (D) The second pathological biopsy result revealed lymphoma (Hematoxylin & Eosin staining, x20).


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. Biopsy of a cervical lymph node performed on day +36 showed effacement of the architecture due to numerous granulomas (low magnification.


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. , which were composed of epithelioid cells.


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. Between the granulomas a polymorphous lymphoid infiltrate was noted containing blasts as well as plasma cells (c).


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. The blasts were latently EBV-infected as shown in the immunohistochemical demonstration of EBNA2 (d).


Radiological diagnosis of disseminated tuberculosis. CT scan of the thorax on day +43 after allogeneic stem cell transplantation revealed a borderline sized mediastinal lymph node with central necrosis.


Radiological diagnosis of disseminated tuberculosis. As well as multiple pulmonary nodules.


Dilated intrahepatic and common bile duct with distal rat tailing.


Signet ring cells with intracytoplasmic mucin.


Bone marrow examination showing the diagnosis of pure red cell aplasia after imatinib initiation.


Bone marrow examination showing the diagnosis of PRCA after nilotinib initiation.


Changes in haemoglobin over the course of the treatment in a patient with chronic myeloid leukaemia who developed pure red cell aplasia secondary to imatinib and nilotinib. The effect of each intervention in the haemoglobin count is depicted. Hb, haemoglobin.


Preoperative intraoral picture.


Preoperative orthopantomograph.


Preoperative computed tomography scans (axial view).


Intra-operative picture.


Enucleated mass.


Follow-up orthopantomography showing corrected eruption axis of canine.


(A) Sagittal T2-weighted magnetic resonance (MR) imaging demonstrating a high-intensity zone (HIZ, arrow) of the L5/S1 intervertebral disc (IVD) at the posterior annulus.


(B) Axial ultrasound (US) imaging of the L5/S1 interlaminar space showing the in-plane injection of the L5/S1 IVD. Note the needle shaft (void arrowheads) was partially blocked by the articular processes. Dashed arrow: posterior longitudinal ligament. Arrowhead: needle tip.


Paramedian sagittal oblique US imaging of the lumbar spine with the window between the tip of the transverse process, and ,the superior articular process.


The window for interlaminar space showing the needle tip (arrowhead) within the IVD. Note the IVD was situated between the two hyperechoic bony cortex of vertebrae (^). The small inserts illustrate the transducer position and orientation. . Abbreviations: AP, articular process; ES, erector spinae; TP, transverse process; Lam, lamina.


(A) Sagittal T2-weighted magnetic resonance (MR) imaging demonstrating a high-intensity zone (HIZ, arrow) of the L4/5 and L5/S1 intervertebral discs (IVDs) at the posterior annulus.


(B) Axial ultrasound (US) imaging of the L4/L5 interlaminar space showing the in-plane injection of the L4/L5 IVD. Note the needle tip was blocked by the articular processes. Dashed arrow: posterior longitudinal ligament. Void arrowheads: needle shaft.


(C) Paramedian sagittal oblique US imaging of the lumbar spine with the window between the tip of the transverse process and the superior articular process showing the needle tip (arrowhead) within the IVD. Note the IVD was situated between the two hyperechoic bony cortex of vertebrae (^). The small insert illustrates the transducer position and orientation. . Abbreviations: AP, articular process; ES, erector spinae; TP, transverse process.


The Kambin triangle (red dashed line) bordered by the exiting nerve root (the hypotenuse), the thecal sac (the asterisk, the height), and the superior border of the caudal vertebra (the width). Note the anatomic relationships of the transverse process, the exiting nerve root, and the intervertebral disc and the facet joint from cranial to caudal.


A) Non-enhanced CT shows a huge presacral homogenous mass displacing the vagina anteriorly and the rectum on the right side.


B) Sagittal multiplanar reformation of contrast-enhanced CT clearly depicts a fat plan between the heterogeneously enhancing mass and the sacrum.


A) Left panel (H&E, 20x): typical vascular pattern of the SFT. Right panel (H&E, 40x): SFT with extramedullary hematopoiesis (black arrows: megakariocytes; white arrow: an erythroid island).


B) Extramedullary hematopoiesis: immunohistochemical staining highlighting megakariocytes (CD61), nucleated erythroid cells (CD71) and granulocyte precursors (myeloperoxydase).


Patient's pedigree. Arrow indicates proband. Proband's mother and husband are indicated by an asterisk. Only these family members were tested. 'N' means normal karyotypes. Only in proband both cytogenetic and FISH testing were performed.


Histological view of biopsy specimens obtained from. Surgical excision of the supraclavicular fossa lymph node.


Fiberoptic bronchoscopy. The two images show caseous necrosis, epithelioid cell nodules and Langhans giant cell. Magnification, x100.


Pre operative pocket depth of 11 mm on mesial aspect and 8 mm on midbuccal aspect of #21.


LCVG noted on #21.


LCVG was sealed with glass ionomer cement.


PRF was placed in the intrabony defect with #21.


FerriScan of the first patient before chelation, with a liver iron concentration of 9.8 mg/g dry tissue.


FerriScan of the first patient after chelation, with a liver iron concentration of 2.3 mg/g dry tissue.


Diagnostic approach for a 32-year-old male with Clostridium innocuum osteomyelitis. A; (18F)-Fluorodeoxyglucose positron emission tomography (FDG-PET) revealed marked uptake of FDG in the sacroiliac joint and iliac bone.


Diagnostic approach for a 32-year-old male with Clostridium innocuum osteomyelitis. B; Bone marrow biopsy from iliac crest confirmed C. Innocuum infection (Grambiopsy conf1000).


Patient before treatment with vismodegib.


Patient after treatment with vismodegib.


Preoperative Surgical Plan. . Preoperative surgical plan showing the swelling in the anterior area of the mandible, causing buccal and lingual bone expansion and displacement of the incisors.


Gross examination of the incisional biopsy. . Gross examination of the incisional biopsy revealed two firm pieces of 2.5x2x1.2 cm in size; they were reddish white in color and solid in consistency.


Photomicrograph of old incisional biopsy. . (
a) Photomicrograph of old incisional biopsy showing heavily scattered multinucleated giant cells (short arrow) in a background of highly cellular fibrous stroma consisting of mononuclear stromal cells (long arrow) and extravasated red blood cells (original magnification 40x).


Photomicrograph of old incisional biopsy. (
b) Newly formed bone trabeculae and osteoid tissue (star) were noted at the periphery of the lesion (original magnification 40x).


Computed tomography (CT) of the lesion. . (
a) CT of the lesion showing a well-defined multilocular radiolucency with diffuse flecks of radiopacities, extending from the right impacted third molar area to the left first molar area.


Computed tomography (CT) of the lesion. (
b) CT of the lesion showing perforations in the buccal and lingual cortical plates.


Gross examination of the excised lesion. . Gross examination of the excised lesion showing numerous, reddish, hard and soft pieces of tissue that ranged in size, having the average of 2x2x1.5 cm.


Photomicrograph of the excisional biopsy. . (
a) Photomicrograph of the excisional biopsy revealed extensive areas of cell-rich connective tissue stroma containing bands of osteoid matrix and anastomosing immature bone trabeculae (long arrows) (original magnification 40x).


Photomicrograph of the excisional biopsy. (
b) Scattered clusters of multinucleated giant cells (short arrows) (original magnification 40x).


Photomicrograph of the excisional biopsy. (
c) Plump osteoblasts can be seen surrounding the interconnecting immature bony trabeculae. Cellular osteoid (star) and some myxomatous areas (polygon) can also be detected (H&E stain, magnification 100x).


Case number 7 liver enzyme level.


Genital lesions - Before treatment.


Oral lesions - before treatment.


Preoperative CT scan revealed enhancing lesion (asterisk) with the epicentre occupying and widening the right nasal cavity. Medially it causes nasal septum deviation to the left and thinning of the posterior part of the septum. The lesion extends posteriorly to the nasopharynx.


Intraoperative endoscopic examination of the right nostril. The remnant of the friable reddish mass (long arrow) is seen originated and flushed with the posterior part of right nasal septum (short arrow). The mucosa of the right nasal septum (asterisk) is unhealthy.


HBV-DNA and EBV-DNA were detected by the patient. In October 2016, HBV-DNA of the patient was raised to 2.656x10^5 copy/mL, so far, EBV-DNA was still negative. . Abbreviations: CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; MCL, mantle cell lymphoma; HBV-DNA, hepatitis B virus-deoxyribonucleic acid; EBV-DNA, Epstein-Barr virus-deoxyribonucleic acid.


Three sets of three tubes as 1A-1B-1C; 2A-2B-2C; 3A-3B-3C. Set 1 and 2 had patient serum and Set 2 and 3 had fresh normal serum as source of complement. P1-positive cells were added to all nine tubes. Three sets "A," "B," and "C" were incubated at 4 C only, 37 C only, and 4 C followed by 37 C, respectively. After centrifugation, tube "2C" showed hemolysis leading to test being interpreted as positive.


Extraoral photograph showing diffuse swelling on left middle third of face extending antero-posteriorly from 1 cm lateral to left ala of the nose till anterior to the tragus of the left ear and supero-inferiorly from left infra-orbital margin to the left corner of mouth.


Intraoral photograph showing single ill-defined, diffuse swelling on left buccal side of maxilla slight obliteration of vestibule along with expansion of buccal and palatal cortical bone.


Orthopantomograph showing haziness in left maxillary sinus and is more radiopaque as compared to contralateral sinus.


X-ray Water's view, demonstrating haziness in left maxillary sinus with more radiopacity than contralateral sinus.


Immunohistochemical stained hotomicrograph showing CD99 positive cells (x40).


Photomicrograph showing Vimentin positive cells (x40).


Immunohistochemical stained photomicrograph showing CD31 positive cells (x40).


Immunohistochemical stained photomicrograph showing myeloperoxidase positive cells (x40).


Immunohistochemical stained photomicrograph showing epithelial membrane antigen negative cells (x40).


Immunohistochemical stained photomicrograph showing negative staining for synaptophysin marker (x40).


Immunohistochemical stained photomicrograph showing negative staining for CD20 marker (x40).


Postoperative photograph showing complete remission of disease.


Hemoglobin monitoring after lenalidomide use.


Digital radiograph preoperatively:. Radiographs of the right tibia, and ,fibula showing an irregular bone destruction of proximal fibula.


3d CT reconstruction demonstrating lytic bone destruction of right proximal fibula.


MRI revealing a massive vascular tumor with surrounding soft tissue hyperplasia and involvement of the proximal fibular epiphyseal plate.


The photograph during the surgery:. Intraoperative image of the surgical finding of a vascular mass attached to proximal fibula.


Complete curettage of lesion to normal fibular surface.


Macroscopic appearance of the excised lesion.


Histopathological features:. (HE, x40) the fissure-like vessel lumens lined with flattened endothelial cells among the spindle cells.


(HE, x100).


(HE, x200) the spindle shaped cells arranging in fascicular pattern in solid area.


Immunohistochemical analysis revealing positive staining for. CD31 (x100).


CD34 (x100).


ERG (x100) in the majority of spindle cells.


Digital radiograph at 2 years postoperatively:. Radiographs showing reformation of the cortex of the proximal fibula.


3d CT reconstruction demonstrating both uniform bone mineral density, and ,continuous cortical of right proximal fibula.


MRI revealing remarkable regression of lesion without evidence of local recurrence.


Computer tomography scan images of lower abdomen. A. Axial CT with IMT (arrow and dotted) in the urinary bladder.


Computer tomography scan images of lower abdomen. B. Coronal CT with IMT (arrow and dotted) in the urinary bladder.


Inflammatory myofibroblastic tumor in the urinary bladder. A. Low-power view.


Inflammatory myofibroblastic tumor in the urinary bladder. B. High power view showing spindle cells (arrows) with interspersed inflammatory cells (notched arrows).


Immunohistochemical stains for inflammatory myofibroblastic tumor in the urinary bladder. A and B. Tumor cells show positive reactivity for pankeratin and smooth muscle actin.


Immunohistochemical stains for inflammatory myofibroblastic tumor in the urinary bladder. C-E. Tumor cells show negative reactivity for desmin, p63 and ALK.


FISH and immunohistochemistry studies for inflammatory myofibroblastic tumor in the urinary bladder. A. The tumor cells failed to show 2p23 ALK gene rearrangement. The arrows indicate the intact juxtaposed green and red signals in the tumor cells.


FISH and immunohistochemistry studies for inflammatory myofibroblastic tumor in the urinary bladder. B. Tumor cells showed no reactivity (lack of brown staining cells) for uroplakin II.


Images of computed tomography.


Corresponding positron emission tomography. Scan of the patient's abdomen showing the adrenal mass (arrow), 1.5 cm in diameter and standardized uptake value of 9.8.


Low magnification of fine-needle aspiration smears, showing loosely cohesive sheets and single cells of oncocytic pheochromocytoma with Diff-Quik.


Papanicolaou. Stains, (x100).


High magnification of tumor cells showing markedly pleomorphic and bizarre nuclei.


High magnification of tumor cells showing markedly pleomorphic and bizarre nuclei. Show binucleation.


High magnification of tumor cells showing markedly pleomorphic and bizarre nuclei. Show intranuclear pseudoinclusions, (x600).


Bruising lesion localized to the hands with edema and dysesthesia.


ERCP showing a common bile duct (day +35):. Mildly dilated duct with biliary stone (black arrow) before extraction.


With no signs of dilation after stone extraction (6 weeks later).


Endoscopic picture showing deep 2 cm in diameter crater-like ulcer located at the recto-sigmoid junction covered by yellowish slough with inflamed surrounding mucosa (day +104).


A) Axial T1-weighted MRI shows intra- and extra-axial tumor in the bilateral CPA and right cerebellar hemisphere.


B) Axial ADC demonstrates strong restricted diffusion on the tumor (arrows).


C, D) Coronal T2-weighted and sagittal MRI shows mass effect of the tumor in the right CPA.


A, B) Pathological characteristics of medulloblastoma showing carrot-shaped cell with monomorphic hyperchromatic nuclei and Homer Wright rosette appearance.


C, D) Immunohistochemical analysis. Positive Ki-67.


C, D) Immunohistochemical analysis. Synaptophysin. Staining of tumor cells.


Noncontrast transverse CT image of the brain showing venous infarcts with hemorrhage in the bilateral parietal regions of the cerebral hemispheres.


Contrast-enhanced transverse CT image showing the empty delta sign in the superior sagittal sinus posteriorly, with a large infarct in the lefthemisphere causing a midline shift to the right.


T2-weighted axial MR image showing a small area of subcortical white matter edema in the left high parietal parasagittal region due to a venous infarct.


Coronal T1-weighted postcontrast MR image showing empty delta sign due to superior sagittal sinus thrombosis.


Maximum-intensity projection (MIP) MR venography image shows nonvizualization of the anterior portion of the superior sagittal sinus due to thrombosis.


EKG showing atrial fibrillation.


Slit-lamp examination revealed that the cornea of the right eye (A) was transparent, the upper corneal epithelium was poorly healed, and the anterior chamber was normal.


(B) In the left eye, mixed congestion of the bulbar conjunctiva, corneal edema, and white infiltrating foci with crab-like changes with unclear boundaries of approximately 2x3mm2 in the center, unclear lesion boundaries with annular reaction ring, corneal endodermis and Descemet's folds radially perpendicular to the lesion, and sediments adhering to endodermis were observed.


Oct-optic (cassia) examination of the left eye revealed that the central cornea was swollen and cloudy up to a 1/2 depth.


Confocal microscopy of the left eye revealed that epithelial cells at the lesion site were necrotic and absent.


With a large number of inflammatory cells infiltrating the superficial stromal layer.


Turbidity and edema of the stromal layer, blurred endothelium, and highly reflective particles attached to corneal endodermis were also observed (C).


One month after the operation, the left eye infection was under control, and the nubecula remained in the center of the cornea.


MR examination showing the progress of the PML-related FLAIR-hyperintensities (A).


The new multifocal and strong contrast enhancement (B) indicates the PML-IRIS.


The zone of active inflammation and demyelination is again indicated also by the low ADC-rim surrounding the area affected by the JC-virus (C, white arrow).


PET/CT image showing hyperdense lesions in the anterior and posterior right thigh. Views are anterior.


PET/CT image showing hyperdense lesions in the anterior and posterior right thigh. And right lateral.


Surgical resection of the posterior thigh mass.


Ultrasonographic view.


Computerized tomography scan.


Frozen section material.


Foci of squamous cell carcinoma. HE. x5.


Atypical mitotic figures and giant cells with storiform pattern-clustered and scattered polygonal cells to spindle cells with markedly pleomorphic characteristics (inflammatory cell infiltration).


Cells show CD68 positivity on immunohistochemistry.


LISS Coomb's gel card showing three-cell panel antibody screening results at 37 C.


LISS Coomb's gel card showing one to 11-cell panel antibody identification results at 37 C.


Immediate postoperative radiograph.


Follow-up radiograph showing a radio-opaque streak in left ramus area.


Retrieved hub from the cystic cavity.


Irrigation syringe used for toileting of cavity during follow-up period.


DNA Sequencing Profile of the FVIII Gene (Exon 14F) from the Patient and Normal Controls. This Figure Indicates Transition Point Mutation (GAA GGA) in the Patient DNA Sequence that Replaces a Glutamic acid With a Glycine Residue. Underlining Indicates the Position of Point Mutation.


Pedigree. Family history of cancer as reported by the proband (denoted by the arrow), and his brother.


PRP application and bandage at the right tarsal and metatarsal regions in the hind limb of case 1. Healthy, and ,clean wound.


PRP application and bandage at the right tarsal and metatarsal regions in the hind limb of case 1. Window through the layers of cotton.


PRP application and bandage at the right tarsal and metatarsal regions in the hind limb of case 1. Dressing fixation with vetrap.


PRP application and bandage at the right tarsal and metatarsal regions in the hind limb of case 1. PRP application.


PRP application and bandage at the right tarsal and metatarsal regions in the hind limb of case 1. Thermoplastic mesh application.


Extra orally diffuse swelling over the right maxillary sinus extending onto the ala of nose.


Intraoral examination revealed unhealed socket of 17 surrounded by everted margins and necrosed bone within.


Contrast-enhanced computed tomography exhibiting nonhomogeneous enhancing lesion destroying walls of maxillary and ethmoid sinus, upper right alveolus and extending into masticator space and infratemporal region.


Basaloid islands and cord-like structures infiltrating the overlying epithelium, areas of mucous cells and mucin filled spaces are also seen (H&E stain, x40).


Peripheral palisaded arrangement of columnar cells and central loose cells showing stellate reticulum-like appearance with interspersed mucous cells (H&E stain, x400).


Tumour cells forming canalicular and tubular structures enclosing haemorrhagic spaces (H&E stain, x100).


Calretinin negativity ruled out ameloblastoma (IHC stain, x400).


Periodic acid-Schiff (PAS) stain positivity at periphery of islands and cytoplasm of central cells (PAS stain, x400).


Calponin immunostaining shows strongly positive peripheral cells of the lesion suggestive of myoepithelial cells (IHC stain, x400).


CK 19 showed patchy positivity in the center of islands at places and the tubular structures (IHC stain, x400).


Ki-67 index <5% (IHC stain, x400).


Extraoral appearance of an enlarged and fissured upper lip in the patient of the study.


Characteristic appearance of the gingival enlargement in the patient of the study.


Pre treatment panoramic radiographic view of the patient in the study.


Surgical views of maxillary and mandibular anterior sextants of the patient in the study. Pre surgical view.


Surgical views of maxillary and mandibular anterior sextants of the patient in the study. After gingivectomy.


Surgical views of maxillary and mandibular anterior sextants of the patient in the study. Excised tissue.


Histopathological appearance (hematoxylin and eosin staining) showing infi ltrate of plasma cells in a dense collagenous stroma. Low power view (x10).


Histopathological appearance (hematoxylin and eosin staining) showing infi ltrate of plasma cells in a dense collagenous stroma. High power view (x40).


Pre treatment gingival appearance.


Post treatment changes in the gingival appearance.


Pre treatment appearance of the upper lip.


An evident reduction in the lip size post treatment compared to the appearance before the treatment in the patient of the study.


Recurrence of lesion after 8 months correlating with local irritants in the patient of the study.


After oral prophylaxis.


Timeline of patient's course.


Platelet counts and treatment timeline.


Swelling in the anterior hard palate with surface ulceration.


Photomicrograph showing centroblasts (red arrows), ie large atypical pleomorphic lymphocytic nucleus with multiple nucleoli (H & E stain, x400).


CD20 immunostaining showing strong positivity indicating B-cell origin of lymphocytes (IHC stain, x200).


Post-chemotherapy photo showing complete resolution of the lesion followed by hypermelanosis after resolution of the swelling (red arrow).


Frontal view panel showing liver metastasis and thickening of deuodenum and jejunum.


Cushingoid features with cyanosis.


Filter paper test.


Hyperemic and pruritic lesion on the upper lip, reported at Case-4.


Aspect of the upper lip one month later, evidenced remission of lesion.


Ulcerated oral lesions in hard palate reported at Case-5 (
a).


Leishmaniasis lesion in the left malar region reported at Case-6 (
b).


Timeline of the case after admission. (A-C) Time course of CK, myoglobin, plasma creatinine, and levels of uPCR and uACR.


Timeline of the case after admission. (D) Time of treatment regimens and kidney biopsy. CK, creatinine kinase; CYC, cyclophosphamide; uACR, urinary albumin-to-creatinine ratio; uPCR, urinary protein-to-creatinine ratio.


Histopathological findings in a kidney biopsy confirming pauci-immune crescentic GN. Representative photomicrographs of the kidney biopsy including staining for IgA (scale bar: 50 mum), IgG (scale bar: 50 mum), IgM (scale bar: 50 mum), C1q (scale bar: 50 mum), and C3c (scale bar: 50 mum); periodic acid-Schiff staining showing a glomerulus with crescent formation (scale bar: 50 mum); and hematoxylin/eosin staining with myoglobin casts (asterisks, scale bar: 100 mum) and tubulointerstitial inflammation with prominent eosinophilic infiltration (scale bar: 100 mum). C1q, complement component 1q; C3c, complement factor 3 conversion product; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; GN, glomerulonephritis.


Timeline of patient's care.


Pathological aspect of the rectal Kaposi's sarcoma. A; Microscopic aspect of the biopsy of rectal ulceration: the rectal mucosa is infiltrated by an ill-defined cellular fasciculated to diffuse proliferation (HES x10).


Pathological aspect of the rectal Kaposi's sarcoma. B; Microscopic aspect showing spindle cells with little to moderate nuclear atypia surround vascular clefts. Few mitoses are noted. Lymphocytes and plasma cells are admixed (HES x40).


Pathological aspect of the rectal Kaposi's sarcoma. C; IHC with ERG antibody: the lining cells of vascular structures and spindle cells express the ERG endothelial marker (x20).


Pathological aspect of the rectal Kaposi's sarcoma. D; IHC with HHV8 antibody: see the nuclear positive immunostaining of spindle tumor cells (x40).


Large granular lymphocytes in the peripheral blood in July 2017 (Wright-Giemsa staining, x1,000).


An M-peak was observed on serum electrophoresis (arrow) (Figure 3A), and immunofixation showed monoclonal bands of IgG-lambda and faint IgA with an unknown light chain (arrows) (Figure 3B).


Lymphoplasmacytic cells in the bone marrow comprised 5.6% of marrow nucleated cells (Wright-Giemsa staining, x1,000).


A; T2 weighted sagittal cervical spine MRI evidencing segment enlargement and edema of the spinal cord extending from C2 to T1 levels (arrows).


B; Cytospin preparation of the cerebral spinal fluid (magnification x 1000, Wright stain) reveals a cluster of chronic lymphocytic leukemic cells with an admixed immunoblast (solid arrow) and a basophil (open arrowhead).


C; Correlation between CD82 and CD49d expression by mean florescence intensity detected (MFI) using flow cytometry in Rai clinical stage 0 CLL patients in the pilot study: linear trendline (continuous line) and 95% Confidence Interval (interrupted line). CNS case (red square) illustrated for comparison.


Sagittal magnetic resonance images showing low signal intensity changes of the L1 vertebral body on T1-weighted images.


High signal intensity changes on T2-weighted images.


Axial magnetic resonance images showing low signal intensity changes of the L1 vertebral body and pedicle on T1-weighted images.


Sagittal.


Axial. Computed tomography a year after biopsy showing bone remodeling of the previous osteolytic lesion of the L1 vertebral body.


CT for head segment.


Intraoral photograph showing large nonulcerated lesion with obliteration of buccal vestibule.


Occipitomental radiograph showing mixed radiopaque and radiolucent lesion in the right maxilla.


Histopathology showing odontogenic epithelium and ghost cells in the epithelium and in the connective tissue with foreign body reaction (x10).


Van Gieson stain showing positivity toward dentinoid material.


Immunostain showing strong positivity of odontogenic epithelial islands with pan-cytokeratin.


Ghost cell (H & E, x40).


Foreign body giant cell reaction adjacent to ghost cell (H & E, x100).


Patient's family tree.


Histopathological features of the sentinel lymph node. Metastatic malignant melanoma was identified. Specific tumor cells showed signet-ring cell appearance as observed in the inset (magnification, x400) (hematoxylin and eosin stain; magnification, x100).


Treatment and clinical course of the case. Their psychiatric symptoms were evaluated by PANSS. Functioning was assessed using the GAF of the DSM-IV-TR. BMT, bone marrow transplantation; QTP, quetiapine; RIS, risperidone; OLZ, olanzapine; PANSS, Positive and Negative Symptom Scale; GAF, Global Assessment of Functioning Scale.


Bone marrow slide. Bone marrow aspirate showing increased mature plasma cells (14.8% marrow differential) with low N/C ratio, clumped chromatin, eccentric nuclei, inconspicuous nucleoli, and prominent perinuclear huff. Normal maturation of myeloid precursors is seen throughout with appropriate folding and granulation. Marked decrease of erythroid precursors is noted with complete absence in this field (M/E ratio 15.9/1.0).


Removed spleen with thin capsule showing threat of rupture.


This T1-weighted image shows a serpiginous band of hypodensity that represents the separation point between necrotic bone and bone that is undergoing repair. This is pathognomonic of AVN.


This AP x-ray was done 2 weeks post decompression. The patient was asymptomatic at this point, and x-ray shows a normal femoral head.


This coronal T1-weighted image shows progression of AVN with necrosis, flattening of the right femoral head, and post decompression evidence in the femoral neck. There is also edema, which corresponds to the increasing pain the patient was experiencing at this time. There are obvious differences between the left and right femoral heads.


AP view of the right femoral head shows areas of hyperlucency and surrounding sclerosis, as well subtle changes in the shape of the articular surface. The necrosis also spreads into the acetabulum. This x-ray was done just before the patient was referred to a hip revision specialist.


Changes in haemoglobin over time.


Tumor of the frontal sinus. Infiltration of the tumor into frontal sinus.


Tumor of the frontal sinus. Infiltration of the tumor into frontal sinus, coronal view.


Tumor of the frontal sinus. Infiltration of the tumor into the right orbit, coronal view.


Tumor of the frontal sinus. Infiltration of the tumor into the right orbit; axial view.


A painful expansion in the left mandibular region and marked facial asymmetry.


Intraoral examination showed a diffuse swelling in the posterior area of left mandible with erythematous and ulcerated overlying mucosa.


Panoramic radiograph of the primary lesion showed a radiolucent lesion with ill-defined borders extending from the left mandibular second premolar to the second molar.


Histopathologic feature in a low magnification illustrates the nature of the tissue as a mixed odontogenic lesion.


Histopathologic section showed scattered odontogenic islands and pleomorphic giant stromal cells in a malignant dental papilla-like connective tissue (x100).


Hyalinization was seen around some odontogenic islands (x100).


Some amount of dentinoid material was found near the odontogenic epithelial nests (x100).


Some eosinophilic material was found in the malignant counterpart. The histopathologic feature in these areas was very similar to fibroblastic osteosarcoma (x100).


The eosinophilic material in sarcomatous area was osteoid like (x400).


Abdominal ultrasound of the patient. . A hyperechogenic 5.6 x 7.3 cm anchor is observed in segment V of the right hepatic lobe suggestive of an incidental hemangioma.


Myelolipoma evaluation. . Surgical specimen, macroscopic. Amado Polyclinic, Maracaibo- Edo Zulia (10/04/2013).


Histological findings from renal biopsy. A; Periodic acid-Schiff (PAS) staining image of a low-power field (magnification x10).


Histological findings from renal biopsy. B; PAS staining of a high-power field (magnification x20). All the glomeruli were involved by "cellular" crescents (black arrows), which suggested that all the crescents were formed very recently.


Histological findings from renal biopsy. C; Masson trichrome staining image (magnification x10).


Histological findings from renal biopsy. D; Periodic acid methenamine silver staining (magnification x10). White arrows indicate interstitial fibrosis and tubular atrophy. Inflammatory cell infiltration was detected in over 50% of the renal interstitium with moderate to severe interstitial fibrosis and tubular atrophy.


Histological findings from renal biopsy. E; Immunostaining for immunoglobulin G (IgG) of a frozen section (magnification x20).


Histological findings from renal biopsy. F-i Immunostaining for IgG subclass. IgG1 is positive.


Histological findings from renal biopsy. , IgG2 and -3 are borderline positive.


Peripheral smear depicting numerous blast cells, mainly immature leukocytes with few erythrocytes and thrombocytes (x25).


Family pedigree of the case showing consanguineous marriage of parent, proband (arrow) and the youngest sister of proband.


Gross photograph of brain showing mild atrophy.


Gross photograph of liver, cut section showing micro and macronodules.


Gross photograph of spleen, cut section showing features of congestion.


Gross photograph of stomach showing dilated stomach with wall thinned out.


Gross photograph of right and left kidney showing shrunken left kidney.


Row A: CT scan four months prior to recto-sigmoid DLBCL diagnosis showcasing mild irregular wall thickening of the recto-sigmoid colon (red arrows) and bladder (yellow arrow). Row B: CT at the time of diagnosis demonstrating significant irregular wall thickening of the recto-sigmoid colon with a large stool-containing collection superimposed on matted loops of inflamed large bowel (blue circle). Center image exhibits a colo-colonic fistula between cecum and rectum (green circle). Third image displays worsening circumferential wall thickening of the bladder (yellow arrow). Row C: Six months post-chemotherapy CT illustrates less wall thickening of the sigmoid colon in the colorectal junction with a smaller area of involvement. The tumor burden is moderately to significantly lower due to smaller soft tissue involvement.


Row A: Pre-chemotherapy PET scan showed intense FDG activity in the sigmoid colon and rectum, mesenteric lymph nodes, and the left lateral posterior aspect of the prostate. Row B: Six months post-chemotherapy PET scan denotes decreased intensity of FDG activity in the sigmoid colon and colorectal junction and resolution of small lesions in the lower abdomen and pelvis.


Preoperative brain MRI sequences. T2-weighted axial.


Preoperative brain MRI sequences. T1-weighted axial without contrast.


Preoperative brain MRI sequences. T1-weighted axial with contrast.


Preoperative brain MRI sequences. T1-weighted coronal with contrast. Images show a bilobular well-defined homogeneous solid mass (arrows) with a medial cystic component (arrowheads) involving the inferior and medial aspects of the right cerebellar hemisphere, consistent with recurrent disease. Adjacent postsurgical changes (asterisks) are also observed.


Intraoperative findings and microphotographs of hematoxylin-eosin-stained slides of the specimen. (a) The devascularized tumor (arrows) is held by a spatula, exposing a vessel containing embolization material (arrowheads). Normal cerebellar parenchyma can be observed on the inferior left corner of the picture.


Intraoperative findings and microphotographs of hematoxylin-eosin-stained slides of the specimen. (b) The abundance of monomorphic stromal cells with pale and vacuolated cytoplasm is consistent with a recurrent hemangioblastoma (40x).


Intraoperative findings and microphotographs of hematoxylin-eosin-stained slides of the specimen. (c) Onyx (arrows) can be observed within a vascular lumen, along with surrounding ischemic-induced pathological changes (10x).


Postoperative brain MRI sequences (13 days later). T2-weighted FLAIR axial.


Postoperative brain MRI sequences (13 days later). T1-weighted axial without contrast.


Postoperative brain MRI sequences (13 days later). T1-weighted axial with contrast.


Postoperative brain MRI sequences (13 days later). T1-weighted coronal with contrast. Images show a small hematoma (arrow) in the medial aspect of the surgical cavity, mild residual edema (asterisk) and minimal linear postsurgical enhancement (arrowhead) without evidence of a residual lesion.


Intra-oral view. Clinical views of the lesion with.


Intra-oral view. Without. The removable prosthesis. These views show a nodulary sessile mass on soft palate with inflammatory aspect on the surface and related to the prosthetic edge.


The 18-FDG PET-scanner of case 1. In cephalic region, we note a focal hyperfixation into the right palate which can correspond to a post-operative inflammation. In the thoraco-abdomino-pelvic region, there are two clavicular, one mesenteric and one right inguinal nodes.


Clinical and radiological presentation of case 2. Is observed on panoramic X-ray.


Clinical and radiological presentation of case 2. No dental infection in relation to buccal swelling.


Facial magnetic resonance imaging (MRI) of case 2. Axial slice through mandibular body showing an elongated and well limited mass (*) slightly enhanced by gadolinium in T1 weighted image and laying in the buccal corridor against the buccal cortex.


Microscopical views of case 2. (a) Lymphoid proliferation clustered into identifiable nodules (HE, x 4).


Microscopical views of case 2. (b) Centroblast cells are mainly observed in the field of view with many mitoses (HE, x 40).


Right temporal lobe biopsy. HE staining. Magnification is x40. Mildly hypercellular and gliotic gray matter with focal reactive changes. No neoplasia is seen.


Magnetic resonance images from the original patient presentation in 2007. (a) Preoperatively, axial T1-weighted contrast images demonstrated a mass lesion located along the right tentorium, extending toward the temporal lobe and the pons.


Magnetic resonance images from the original patient presentation in 2007. (b) Postoperative T1-weighted contrast image. A tumor invading into the cavernous sinus (arrow) remained. The extent of resection was judged as "subtotal.


Preoperative magnetic resonance images of the spinal cord. (a, b) Sagittal T1-weighted images with gadolinium, demonstrating intraspinal disseminated lesions that were increased in size (arrowheads). Note the T11/12 lesion (arrow in B) compressing the spinal cord.


Preoperative magnetic resonance images of the spinal cord. (c) Axial T1-weighted contrast image demonstrating the T11/12 tumor now causing a deformity of the spinal cord.


Preoperative magnetic resonance images of the spinal cord. (d) Sagittal T2-weighted image demonstrating an abnormal hyperintense area in the dorsal spinal cord where the T11/12 lesion is located (arrow).


Intraoperative photographs following left T11 hemilaminectomy. (a) Following the dural opening, a mass lesion was visible underneath the arachnoid membrane (arrow).


Intraoperative photographs following left T11 hemilaminectomy. (b) Subtotal surgical resection was performed. A layer of the tumor was left attached to the dorsal spinal cord (arrow). Note that the left and right sides of the images were the rostral and caudal sides, respectively.


Histological examination of the tumor cells with hematoxylin and eosin staining, the findings of which were compatible with the diagnosis of hemangiopericytoma. Scale bar = 100 mum.


Follow-up magnetic resonance images 16 months after resection. (a) Axial T1-weighted image of the brain, demonstrating an intracranial mass lesion (arrow) that was stable in size. Note that it had an altered intensity following the gamma knife treatment.


Follow-up magnetic resonance images 16 months after resection. (b, c) Sagittal T1-weighted images demonstrating spinal disseminated lesions (arrowheads) that were stable in size. The resected spinal tumor (arrow) did not recur.


The treatment course of this case. ABVD, doxorubicin + bleomycin + vinblastine + dacarbazine; AE, adverse event; ASCT, autologous stem cell transplantation; BEAM, carmustine + etoposide + cytarabine + melphalan; CR, complete remission; HL, Hodgkin's lymphoma; GDP, gemcitabine + cisplatin + dexamethasone; mAb, monoclonal antibody; PD-1, programmed death-1; PD-L1, programmed death-ligand 1; PR, partial remission.


Peripheral blood smear with a nucleated red blood cell, polychromasia, "fragmented" RBCs and thrombocytopenia. The arrow points to a dysmorphic "fragmented" RBC (Wright 's stain, original magnification x1000).


Timeline summary showing gradual improvement of ongoing hemolysis demonstrated by decreasing bilirubin and serum lactate dehydrogenase (LDH) levels.


Timeline summary showing gradual improvement of anemia and thrombocytopenia demonstrated by increasing hemoglobin (Hb) and platelets. Two packed red blood cells were transfused on day 0 and day 4.


Body temperature change after CAR T-cell therapy. . Abbreviation: CAR, chimeric antigen receptor.


CRP change after CAR T-cell therapy. . Abbreviations: CRP, C-reactive protein; CAR, chimeric antigen receptor.


Expansion of CAR T-cell from peripheral blood after therapy. . Abbreviation: CAR, chimeric antigen receptor.


Pelvic ultrasound results of the patient before and after CAR T-cell therapy. . Notes:. Ultrasound results from day -7 before CAR T-cell therapy.


Pelvic ultrasound results of the patient before and after CAR T-cell therapy. Day +28, day +60, day +90, day +120, and day +360 ultrasound results after CAR T-cell therapy. . Abbreviation: CAR, chimeric antigen receptor.


Pathological features: heteromorphic large lymphocyte proliferation, HE staining, magnification, 400x.


PET/CT scan results before chemotherapy: multiple hypermetabolic lymph nodes along bilateral inguinal regions.


External iliac vessels The red arrow points to hypermetabolic lymph nodes.


In-situ hybridization for Epstein-Barr virus-encoded RNA is scattered positive, HE staining, magnification, 400x.


PET/CT scan results after the 4th chemotherapy: slightly larger lymph nodes lacking significant metabolic increases along the inguinal regions.


The external iliac vessels The red arrow points to slightly larger lymph nodes.


Cranial computed tomography at the onset of the loss of consciousness and respiratory arrest showing multiple intracranial hemorrhagic legions.


Pure-tone audiometry. Both air conduction and bone conduction thresholds worsened, and there were no significant differences between air and bone conduction thresholds. This patient developed bilateral sensorineural hearing loss.


The patient was treated with imatinib but developed sensorineural hearing loss. She received hydroxyurea, and her treatment was changed from imatinib to nilotinib. However, she suddenly lost consciousness and experienced respiratory arrest. She received intensive care but died 14 days after hospitalization.


Case 4. A 23-month-old boy with a hemangioma in the right zygomatic region. (a) Preoperative photograph.


Case 4. A 23-month-old boy with a hemangioma in the right zygomatic region. (b) A zig-zag incision was selected in the first operation. Three intralesional excisions were performed.


Case 4. A 23-month-old boy with a hemangioma in the right zygomatic region. (c) Results at 3 days after the initial operation.


Case 4. A 23-month-old boy with a hemangioma in the right zygomatic region. (d) Design of the incisional line in the second operation.


Case 4. A 23-month-old boy with a hemangioma in the right zygomatic region. (e) Design of the incisional line in the last operation.


Case 4. A 23-month-old boy with a hemangioma in the right zygomatic region. (f) Results at 6 months after the last operation. The resulting scar was not conspicuous, and the outcome was judged as excellent.


Case 11. A 55-month-old girl with a fibrofatty tissue and a scar due to a large hemangioma on the lower lip. (a) Preoperative photograph.


Case 11. A 55-month-old girl with a fibrofatty tissue and a scar due to a large hemangioma on the lower lip. (b) Design of the incisional line in the first operation.


Case 11. A 55-month-old girl with a fibrofatty tissue and a scar due to a large hemangioma on the lower lip. (c) Results immediately after wound closure.


Case 11. A 55-month-old girl with a fibrofatty tissue and a scar due to a large hemangioma on the lower lip. (d) Results at 6 months after the initial operation.


Case 11. A 55-month-old girl with a fibrofatty tissue and a scar due to a large hemangioma on the lower lip. (e) Results at 4 months after the second operation. The outcome was judged as good.


Standard weight-bearing knee X-rays of a 77-year-old female before.


8 months after. One course of intra-articular PRP in association with HA injection, showing the increase in medial joint space (white arrows). . Abbreviations: HA, hyaluronic acid; PRP, platelet-rich plasma.


Standard weight-bearing knee X-rays of a 69-year-old female before.


15 months after. One course of intra-articular PRP in association with HA injection, showing significant improvement in the narrowing joint space (white arrows). . Abbreviations: HA, hyaluronic acid; PRP, platelet-rich plasma.


Standard weight-bearing knee X-rays of a 76-year-old female before.


1 year after. Two courses of intra-articular PRP in association with HA injection, showing more significant bone spur growth and the cartilage remains at a healthy size with the normal joint space (white arrows). . Abbreviations: HA, hyaluronic acid; PRP, platelet-rich plasma.


Lesion over the left maxilla producing facial asymmetry.


Extensive gingival proliferation of left maxilla covering the teeth in the involved area.


OPG showing root stumps without much destruction of bone.


Hyperplastic epithelium with acanthosis (H&E stain, x40).


Sheets of tumor cells in the underlying connective tissue (H&E stain, x400).


Positive staining with immunohistochemical marker CD68 (IHC stain, x400).


Positive staining with immunohistochemical marker CD117 (IHC stain, x400).


Positive staining with immunohistochemical marker MPO (IHC stain, x100).


Graphic summary of the case.


Transverse CT scan of the oral cavity showing an oral tumor at diagnosis.


30 days after the initiation of bortezomib treatment.


(A) Ultrasonography showed bilateral thyroid reduction and multiple nodules (<0.5 cm in diameter) in the left lobe with normal blood flow signals.


(B) Ultrasonography showed thyroid enlargement with diffuse reduction in gland echo and abundant blood flow signals.


Biopsy of soft tissue lesions:. HE staining.


ALK staining.


CD30 staining. . Note: Magnification for all images: 400x. . Abbreviations: HE, hematoxylin and eosin; ALK, anaplastic large cell lymphoma kinase.


Hip view shows multiple discrete myelomatous lesions in the pelvis and a lucent lesion in the left femoral neck.


FDG PET/CT scan. (A) Extensive nodular increased activity most evident in long bones such as both humeri and femurs.


FDG PET/CT scan. (B) Conspicuous foci with intense activity are seen in the medial condyle of the right femur (SUV 3.3) and left acetabular roof and femoral neck where a 3 cm lytic lesion is seen with cortical destruction (SUV 15.8).


Initial presenting electrocardiogram: sinus rhythm with premature atrial and ventricular contractions, ST Elevation and Q waves in II, III, and aVF and tall R wave in V2 consistent with infero-post wall MI, STEMI.


Right coronary artery (RCA) pre-intervention revealing 90% occlusion of the mid RCA with thrombus formation.


Right coronary artery (RCA) after bare metal implantation in the mid RCA.


Axial CT image of the pelvis demonstrates a large fat containing mass within the presacral region (arrowheads). Fat within the mass is dark on the CT images (arrow).


Axial nonfat saturated . Bright fat on nonfat saturated image.


Fat saturated. T2-weighted MRI images of the pelvis also demonstrates a large fat containing mass within the presacral region (arrowheads). Saturates out on the fat saturated image. (arrows).


Chest radiography revealed consolidation in the right lower lung field at the initial visit.


Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


Preoperative photograph of the patient, taken anteriorly.


T1 weighted contrast bilateral breast MRI demonstrating a soft tissue intensity mass-like area attached to the right breast capsule with internal enhancing foci and trace periprosthetic fluid, in addition to enhancing foci at the deep margin of the left breast capsule.


Intraoperative photograph of bilateral explanted, textured, silicone breast prostheses and right breast capsule. There is evidence of bilateral rupture with hematoma within the implants.


Immunohistochemistry for CD68, a histocyte marker, highlights numerous foam histocytes within the lesion on the external surface of the right capsule.


This image shows vacuolated histiocytes and a foreign body-type giant cell, features of the silicone granuloma taken from the lesion on the external surface of the right capsule.


Platelet count response in the patient following IVIG infusion. IVIG: Intravenous immunoglobulin.


Treatment process after post-operative relapse. PFS, progression-free survival; FOLFIRI, irinotecan, leucovorin, and fluorouracil; Bev, bevacizumab; PD, progressive disease; SD, stable disease; PR, partial response; mos, months.


Cervical Magnetic Resonance Imaging (MRI) at clinical onset demonstrating a longitudinally extensive signal abnormality involving the cervical spinal cord, extending from the obex to D3. The cord appears markedly swollen, both gray and white matter are involved, and post-contrast sequences demonstrate marked cord enhancement between C3 and C5 (red arrows). Findings are compatible with acute longitudinally extensive transverse myelitis (LETM).


Follow-up MRI scans at 20.


55. Days, showing progressive reduction of the spinal cord swelling and contrast enhancement. In (B), contrast enhancement has completely regressed, due to blood-brain barrier restoration, and the spinal cord shows a near-normal appearance with no residual disease. No spinal cord atrophy is noted.


Tufted hair folliculitis on the scalp, a patch of alopecia characterized by perifollicular erythema and follicular hyperkeratosis.


The patient showed clinodactyly of the fifth finger of both hands.


More evidently on the left side, confirmed by X-ray examination.


Imaging and histological findings of spinal hemangioblastoma during puerperium. . Notes: (A, B) MRI presentation of the tumor in the immediate postpartum period. (A) Contrast-enhanced T1-weighted sagittal section showing a hyperintense solid nodule at D11-D12 (white arrow). Tumor volume of 1.7 cm3.


Imaging and histological findings of spinal hemangioblastoma during puerperium. . Notes: (A, B) MRI presentation of the tumor in the immediate postpartum period. (B) T2-weighted sagittal section showing bulbocervical edema (*) and extensive hydrosyringomyelia (dotted white arrow).


Imaging and histological findings of spinal hemangioblastoma during puerperium. (C, D) MRI presentation of the tumor after 55 days. (C) Reduction in tumor size (tumor volume of 1.0 cm3) but showing the same image characteristics: intense contrast enhancement (solid white arrow).


Imaging and histological findings of spinal hemangioblastoma during puerperium. (C, D) MRI presentation of the tumor after 55 days. (D) Same caudal and cranial hydrosyringomyelia at C3 (dotted white arrows) but complete disappearance of medullary edema.


Imaging and histological findings of spinal hemangioblastoma during puerperium. (E) Histopathology (H&E) showing vascular proliferation surrounded by stromal cells with clear nuclei, a characteristic feature of hemangioblastoma (total magnification: 400x).


Imaging and histological findings of spinal hemangioblastoma during puerperium. (F) Immunohistochemical staining that was positive for inhibin in stromal cells and negative for estrogen and progesterone receptors (the positivity for estrogen and progesterone receptors would be demonstrated by brown staining in the cell nuclei; total magnification: 400x). . Abbreviation: MRI, magnetic resonance imaging.


Positive immunohistochemical stains and Ki-67 proliferation index of liver biopsy sample (20x magnification). (A) Neuron-specific enolase.


Positive immunohistochemical stains and Ki-67 proliferation index of liver biopsy sample (20x magnification). (B) Synaptophysin.


Positive immunohistochemical stains and Ki-67 proliferation index of liver biopsy sample (20x magnification). (C) Ki-67 proliferation index 98.


An ill-defined poorly enhancing lesion involving segment IVA, IVB and caudate lobe (segment I) of the liver with minimally exophytic component at the medial aspect and associate prominence of intrahepatic biliary radicals in the left lobe liver suggesting possible compression over the left hepatic duct.


Moderately cellular showing discohesive round, medium to large size cells having moderate to scanty cytoplasm and vesicular nuclei, prominent nucleoli with nuclear membrane irregularity and notching (Pap, x1000).


A; Ulcer with prominent necrotic tissue on the right shin.


B; Just before the administration of bexarotene.


C; Eight weeks after the administration of bexarotene.


Blood smear of the patient at presentation. Photomicrograph of the blood smear shows ring forms of Plasmodium falciparum (x 1000 magnification; Giemsa stain).


Radiological, cytological, histological, immunophenotypic, and cytogenetic findings of AL-HGBL. A F-18-fluorodeoxyglucose (FDG) positron emission tomography detected the strong accumulation of FDG in the liver, spleen, and whole-body bone areas. B; Bone marrow preparations stained with Wright-Giemsa (WG) and hematoxylin-eosin (HE) detected sheets of blastoid cells with fine chromatin and only a few vacuoles. Leukemic cells were strongly positive for CD20, CD10, and BCL2, and weakly positive for BCL6.


Radiological, cytological, histological, immunophenotypic, and cytogenetic findings of AL-HGBL. A F-18-fluorodeoxyglucose (FDG) positron emission tomography detected the strong accumulation of FDG in the liver, spleen, and whole-body bone areas. C; The karyotype of bone marrow cells was examined using G-banding. Red arrowheads indicate the derivative chromosomes.


Radiological, cytological, histological, immunophenotypic, and cytogenetic findings of AL-HGBL. A F-18-fluorodeoxyglucose (FDG) positron emission tomography detected the strong accumulation of FDG in the liver, spleen, and whole-body bone areas. D; The FISH analysis of interphase cells confirmed that t(14;18)(q32;q21) resulted in fusion between IGH (green) and BCL2 (red) and also that one MYC split signal (red) was located beside the two amplified MYC genes. In addition, the FISH analysis of metaphase cells indicated the amplification of MYC (red) at 8q24 in derivative chromosome 8 and did not fuse to IGH (green). White arrows indicate these aberrations.


Radiological, cytological, histological, immunophenotypic, and cytogenetic findings of AL-HGBL. A F-18-fluorodeoxyglucose (FDG) positron emission tomography detected the strong accumulation of FDG in the liver, spleen, and whole-body bone areas. E; SKY revealed that 8q24 and 19q13.1 were translocated to chromosomes 2 and 11, respectively. In addition, the loss of chromosome 17p was confirmed because derivative chromosome 22 contained chromosome 17q. White arrows indicate the derivative chromosomes and marker chromosomes detected by G-banding.


Trend of gamma-globulin dosage during the disease course.


Computed tomography (CT) of the torax. A; Pathological tissue with elongated morphology of maximum diameter of 6 cm.


Computed tomography (CT) of the torax. B; Almost complete disappearance of the pathological mass previously observed.


Magnetic resonance imaging characteristics and liver biopsy histopathology. (A) Axial view from enhanced abdominal magnetic resonance imaging revealed a liver mass located in the right lobe without typical enhancement.


Magnetic resonance imaging characteristics and liver biopsy histopathology. (B) Hematein eosin stain composed of a small amount of abnormal mitotic cells, lacking the portal triads or bile ducts (original magnification x 200).


Magnetic resonance imaging characteristics and liver biopsy histopathology. (C) Immunohistochemical showed beta-catenin was positive on membrane, not nuclei (original magnification x 200).


Magnetic resonance imaging characteristics and liver biopsy histopathology. (D) The radiology images showed that the mass shrank significantly.


Hemoglobin trend during hospitalization with intravenous artesunate therapy followed by artemether-lumefantrine; with hemoglobin level < 7 g/dL at three instances during hospital admission, requiring packed red blood cell transfusions (green arrows).


Ultrasound of the abdomen showing ill-defined hypoechogenic lesions in pancreatic head.


Spleen.


MRI cervico-dorsal region showing a well-defined intramedullary lesion at D4 with syrinx rostral to the lesion.


MRI whole spine showing associated holocord syrinx.


Patient 1. Light microscopy shows an intact glomerulus without hypercellularity or thickened glomerular capillary walls (A).


Patient 1. By electron microscopy, there is prominent widening of the subendothelial space by edema, cell debris, and amorphous proteinaceous deposits (B). X10,000.


Patient 2. Light microscopy shows an intact glomerulus without hypercellularity or thickened glomerular capillary walls (A). By electron microscopy, there is prominent widening of the subendothelial space by edema, cell debris, and amorphous proteinaceous deposits.


Patient 2. Partial basement membrane reduplication is present (B). X8,000.


Patient 3. Light microscopy shows an intact glomerulus with prominently thickened capillary walls and segmental mesangial hypercellularity (A). By electron microscopy, there is prominent widening of the subendothelial space by edema, cell debris, and amorphous proteinaceous deposits.


Patient 3. Basement membrane reduplication is complete (B). X8,000.


Significant heterogeneous enhancement is observed with evident edema after gadolinium administration (A-C).


A follow-up MRI, 3 months after surgery (D-F), showed that the lesion was completely removed, without any signs of recurrence.


Giant cell glioblastoma is composed of large, closely-arranged cells, with an eosinophilic cytoplasm and obvious nuclear atypia. There are also scattered multinucleated giant cells. Local necrosis and vascular proliferation are observed (A).


Giant cell glioblastoma is composed of large, closely-arranged cells, with an eosinophilic cytoplasm and obvious nuclear atypia. There are also scattered multinucleated giant cells. FISH detection suggests no loss of heterozygosity in 1p.


Giant cell glioblastoma is composed of large, closely-arranged cells, with an eosinophilic cytoplasm and obvious nuclear atypia. There are also scattered multinucleated giant cells. Or 19q
 chromosomes.


Giant cell glioblastoma is composed of large, closely-arranged cells, with an eosinophilic cytoplasm and obvious nuclear atypia. There are also scattered multinucleated giant cells. Primary intracranial leiomyosarcoma showing spindle-shaped cells.


Giant cell glioblastoma is composed of large, closely-arranged cells, with an eosinophilic cytoplasm and obvious nuclear atypia. There are also scattered multinucleated giant cells. Abundant mitotic activity. Through the tumor, hematoxylin, and eosin staining.


Giant cell glioblastoma is composed of large, closely-arranged cells, with an eosinophilic cytoplasm and obvious nuclear atypia. There are also scattered multinucleated giant cells. Immunohistochemical examination was positive for H-caldesmon (F).


Pyrosequencing demonstrates that no O6-methylguanine-DNA methyltransferase promoter methylation was found.


Hypointense signal is seen on T1WI.


Isointense and slightly hyperintense signals were seen on T2WI.


Isointense signal on FLAIR.


Significant enhancement was seen after gadolinium administration, without uniform enhancement in the center of the lesion (D-F).


Immediate postoperative CT ,follow-up MRI.


3 months after surgery. Demonstrated complete removal of the tumor and no signs of recurrence.


Pulmonary function testing with a bronchodilator revealing severe obstructive and restrictive failure without bronchodilator response.


Pulmonary ventilation and perfusion scintigraphy revealing a mosaic pattern of radio-isotope uptake decrease without ventilation-perfusion mismatch.


Diffuse cutaneous hemorrhage over the thigh.


Trends of APL cells counts in CSF.


(a)Testicular plasmacytoma CT scan axial section preoperative picture showing right testicular mass.


B: Testicular plasmacytoma CT scan coronal section preoperative picture showing right testicular mass.


(a) Axial contrasted computed tomography (CT) scan demonstrates a small ovoid iso-attenuating mass in the left tonsil. The large mixed solid-cystic nodal-mass conglomerate in the left side of the neck exerts mass effect on the left carotid space and displaces it medially.


(b) Coronal contrasted CT scan demonstrates the cranio-caudal extent of the nodal-mass conglomerate in the left side of the neck. The cranial aspect is solid and enhancing, and the caudal portion is cystic and multiseptated.


(a) Sagittal T1-weighted, post-gadolinium, fat-saturated magnetic resonance (MR) image shows the mixed solid-cystic nature of the cervical nodal-mass with enhancement of the cranial solid portion. Superficial parotid gland infiltration was suspected based on MR imaging findings.


Axial T1-weighted MR images with. Gadolinium.


Fat suppression demonstrating heterogenous enhancement of the solid cranial portion of the cervical nodal-mass conglomerate. The left carotid arteries and internal jugular vein were not infiltrated.


Intra-operative image of the left cervical nodal-mass conglomerate. It was dissected off the left common carotid artery, with ligation of the left internal jugular vein.


Follicular dendritic cell sarcoma of the left tonsil:. The tumour appears very cellular, displaying a typical storiform, and ,whorled growth pattern (haematoxylin, and ,eosin, 100x).


By immunohistochemistry, the tumour shows diffuse membranous positivity with follicular dendritic cell markers D2-40 (haematoxylin and eosin, 400x), as well as CD21, CD23, CD35 (not shown).


Metaphase fluorescence in situ hybridization using CEP(3) (#3) and CEP(12) (#12) probes, along with the TEL/AML1 translocation dual fusion probe, confirmed an involvement of chromosome 3 with chromosome 12 in this case. A; TEL (ETV6) signal was located on der(3). CEP, chromosome enumeration probe; #, chromosome; der, derivative chromosome.


Gel electrophoresis of multiplex reverse transcription-polymerase chain reaction products from the present case. Lanes 1, negative control; 2, internal control (beta2-microglobulin; 535 bp) and 3, ETV6-MDS1-EVI1 fusion transcript (144 bp). MDS1, myelodysplastic syndrome; EVI1, ectopic viral integration site 1.


Chest x-ray showed slight thickening of the interstitial web with mild bilateral pleural effusion.


Morphological analysis of the bone marrow aspirate shows rich cellularity, more than 90% of which is replaced by blastic elements with a probably lymphoid habitus and a high nucleus/cytoplasm ratio.


Cranial CT scan of the patient with right sided forehead and ocular adnexal mass showing normal ocular dimensions without any intracranial connection.


The patient with massive right sided forehead and ocular adnexal mass after incisional biopsy.


Histologic section shows small lymphocytes with mildly pleomorphic vesicular nuclei, arranged diffusely.


The same patient after the second course of chemotherapy; considerable reduction occurred in the size of the adnexal mass.


12 lead electrocardiogram (ECG) of the patient at the time of presentation. ECG showing T wave inversion in precordial leads from V1 to V6. There is no shift of ST segments.


Coronary angiogram in the left anterior oblique caudal view showing eccentric narrowing the proximal left anterior descending coronary artery with 75% stenosis.


Coronary angiogram showing successful result of angioplasty and stenting to proximal left anterior descending coronary artery.


12-lead ECG showing normalization of the ischemic changes on follow up.


Cytology aspect of the M7-AML. . Notes: (A-C) Acute megakaryoblastic leukemia showing dysplastic megakaryoblasts.


Cytology aspect of the M7-AML. (D and E) Micromegakaryocytes.


Cytology aspect of the M7-AML. (F) MPO staining. Magnification x20. . Abbreviations: MPO, myeloperoxidase; M7-AML, acute megakaryocytic leukemia.


Renal arteriolar wall thickening, mild interstitial fibrosis and tubular atrophy areas.


Ischaemic glomeruli and artery wall thickening with thrombotic microangiopathy changes.


Contrast-enhanced computed tomography revealed a 4.4-cm mass at the head of the pancreas, as indicated by the arrow.


The peripheral blood smear showed macrocytic hypochromic anemia with schistocytes, as indicated by the arrows.


Anterior segment OCT taken after second vitrectomy shows clearance of the anterior vitreous and a well visualized posterior capsule.


Bone marrow aspirate showing plasma cells actively producing immunoglobulins "Mott cells.


Hemophagocytosis of RBC and neutrophils.


Lymph node biopsy showing: large histiocytes with emperipolesis (black arrows) and plasma cells with large inclusions containing immunoglobulins "Russel body" (yellow arrow).


Immunohistochemical staining of lymph node biopsy, positive for S100.


Immunohistochemical staining of lymph node biopsy, positive for CD68.


Immunohistochemical staining of lymph node biopsy, negative for CD1a.


Immunohistochemical staining of lymph node biopsy, negative for CD21.


Gross appearance and pathological findings of the steroid cell tumor. Tumor surface was smooth and white without adhesion to surrounding area (A).


Gross appearance and pathological findings of the steroid cell tumor. Cut surface showed a monotonous yellow fat-rich appearance (B). The tumor was composed of both eosinophilic and vacuolated cytoplasm.


Gross appearance and pathological findings of the steroid cell tumor. Tumor cell infiltration into the capsule (arrow) was observed (C).


Gross appearance and pathological findings of the steroid cell tumor. Tumor cells showed spontaneous severe nuclear atypia (D).


Gross appearance and pathological findings of the steroid cell tumor. Tumor hemorrhage.


Gross appearance and pathological findings of the steroid cell tumor. Necrosis. Were observed.


Gross appearance and pathological findings of the steroid cell tumor. Venous infiltration of tumor cells was observed (G, H). Original magnification, x10 in C,. X40 in E.


Gross appearance and pathological findings of the steroid cell tumor. Venous infiltration of tumor cells was observed (G, H).


Gross appearance and pathological findings of the steroid cell tumor. Inhibin-positive cells were demonstrated by brown color on immunostaining (I). . X100 in D.


(a) MRI (diffusion-weighted image) showing right corona radiate infarction.


(b) MR angiography (MRA) reveals right middle cerebral artery (MCA) occlusion.


(c) Four hours after tPA administration, the right MCA was recanalized.


(b) Autopsy of the lung tissue (x20) (Case 3) showing inflammatory cell infiltrate of septae and extravasation of red blood cells into alveolar spaces.


Distinct Cytoplasmic patterns identified in Hep-2 ANA IIF (Euroimmun).


Microscopic section. Hematoxylin and eosin stained section of the bone marrow showing hypoplasia, x20 (A).


Microscopic section. Hematoxylin and eosin stained section of the bone marrow showing hypoplasia, x40 (B).


Microscopic section. Alcian blue staining demonstrates serous degeneration, x20 (C).


Microscopic section. Immunostaining for CD8, x20 (D).


Brain MRI performed 45 days after the first attack. Results showed almost complete regression of the WM abnormalities (compared with Figure 1).


Platelet count changes during trastuzumab therapy:. Before each trastuzumab infusion.


During the 10th infusion of trastuzumab.


During the 11th infusion of trastuzumab.


Colonoscopy. There are multiple irregular ulcers in the colon. (A) Ascending colon.


Colonoscopy. There are multiple irregular ulcers in the colon. (B) Sigmoid colon.


Whole abdominal CT. CT scan showing wall thickening of the colon (arrows). CT scan showing a large amount of free gas in abdominal cavity (arrow). (A) Coronal view.


Whole abdominal CT. CT scan showing wall thickening of the colon (arrows). CT scan showing a large amount of free gas in abdominal cavity (arrow). (B) Sagittal view.


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. , Timeline showing absolute CD4 and CD8 T cell counts, including effector-memory subsets and NK cell counts (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. Absolute B cell counts (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. , Anti-SARS-CoV-2 S protein IgG, IgA and IgM antibody levels as assessed by an in-house developed Luminex assay for each plasma The cytopathic effect on VeroE6 cells was evaluated after inoculation with SARS-CoV-2 from nasopharyngeal swabs: C+, successful virus isolation; C-, absence of virus isolation. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. As well as in the patient's serum before and following plasma transfusions (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. (E), Activity of neutralizing antibodies was assessed by a SARS-CoV-2 pseudovirus neutralization assay for each plasma and in patient's serum at different time-points. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. (F), Over-time follow-up of SARS-CoV-2 RNA detection in nasopharyngeal swabs. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


The image shows a 17 mm high intensity area in the pons on T2-weighted.