(D) Formalin fixed paraffin-embedded tissue used for in situ hybridization for Epstein-Barr virus-encoded early RNAs. The result was negative.


CfDNA monitoring of EGFR ex19del and EGFR T790M mutations. Each dot corresponds to a different liquid biopsy time point. AF, allele frequency; CT, chemotherapy with platinum-etoposide.


Drug screening in a primary cell line following osimertinib resistance. Primary cells were treated with 250 nM osimertinib, 0.150 mug/ml etoposide, and 0.05 mug/ml cisplatin. After 72 h, cell proliferation was assessed by CellTiter 96. AQueous One Solution Cell Proliferation Assay (MTS). Data are expressed as percent of cell viability vs. control cells and are means +- SD of three measurements. *p < 0.05.


MRI Brain (T2 axial) of the patient done five months after onset of neurological symptoms revealing normal study.


Electroencephalograph of the child (Monopolar montage, Sensitivity of 20 microvolt/mm, Speed 30 sec/page) showing periodic slow wave complexes lasting for 1.5 to 2 seconds occurring at a regular interval of 18 seconds.


Transesophageal echocardiographic examination showing a large atrial septal defect. Arrowheads).


A large parachute-shaped mass attached to aortic valve. Right arrowheads), and . A large mass in the left atrial appendage. Left arrowheads, Video 1), suggestive of vegetation in a patient with intravenous drug abuse and Pseudomonas endocarditis.


Transesophageal echocardiographic examination demonstrating multiple vegetation attached to mitral valve leaflets. Arrowheads) with a large fluttering saccular mass (1.4 cm x 4 cm) in the left atrium attached to the posterior mitral valve leaflet bulging into the left atrium suggesting mitral valve aneurysm. Arrowheads, Video 1) in a patient with intravenous drug abuse and Pseudomonas endocarditis.


Arrowheads) with a large fluttering saccular mass (1.4 cm x 4 cm) in the left atrium attached to the posterior mitral valve leaflet bulging into the left atrium suggesting mitral valve aneurysm. Arrowheads, Video 1) in a patient with intravenous drug abuse and Pseudomonas endocarditis.


Transesophageal echocardiographic examination showing a large left atrial vegetation intermittently resembling a "cat" face with prominent eyes, nose, and mouth (Video 2) measuring 4.9 cm x 1.9 cm in a patient with intravenous drug abuse and Pseudomonas endocarditis.


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (a) Axial contrast-enhanced computed tomography scan of the abdomen through the level of the kidney showing mass-like low attenuation lesion (yellow star) in the interpolar region of the right kidney with moderate surrounding perinephric inflammatory changes (blue arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (b) Coronal reformat contrast-enhanced computed tomography scan of the abdomen and pelvis showing mass-like low attenuation lesion (yellow star) in the interpolar region of the right kidney with moderate surrounding perinephric inflammatory changes (blue arrow). There is also mild diffuse bladder wall thickening (red arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (a) Axial contrast-enhanced computed tomography of the abdomen through the level of the kidneys shows low attenuation lesions (yellow star) in the interpolar region of the right kidney with improving perinephric inflammatory changes 3 weeks later (blue arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (b) Coronal reformat contrast-enhanced computed tomography scan through the abdomen showing low attenuation lesions (yellow star) in the interpolar region of the right kidney with improving perinephric inflammatory changes 3 weeks later (blue arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical Bacillus Calmette-Guerin therapy. (a) Axial computed tomography of the abdomen through the level of the kidneys demonstrates a percutaneous computed tomography-guided biopsy of the lesion (blue circle).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical Bacillus Calmette-Guerin therapy. (b) Core needle biopsy from right renal mass showing marked chronic inflammation with granulomas (red circles). Special stains for acid-fast bacilli (Fite) and fungi (GMS) were negative (not shown).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (a) Axial contrast-enhanced computed tomography scan of the abdomen through the level of the kidneys showing interval resolution of the right renal lesions with mild residual cortical scarring 8 months later (blue arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (b) Coronal reformat contrast-enhanced computed tomography scan showing interval resolution of the right renal lesions with mild residual cortical scarring 8 months later (blue arrow).


Contrast-enhanced computed tomography abdomen,. Coronal section showing. Multiple, tiny hypodense splenic lesions (thin arrow) with clustered pattern of distribution in subcapsular location and perisplenic extension (curved arrow).


Contrast-enhanced computed tomography abdomen,. Magnetic resonance imaging abdomen, axial section showing T2-weighted image.


Contrast-enhanced computed tomography abdomen,. Diffusion-weighted imaging. Showing multiple T2 hyperintense lesions with diffusion restriction in the spleen.


Previous treatment with corticosteroids. . Abbreviations: BM, betamethasone; FM, fluorometholone; PSL, prednisolone; HSK1, herpes simplex keratitis (geographic ulcer and stromal keratitis); TLO, trabeculotomy; TLE, trabeculectomy; HSK2, herpes simplex keratitis (stromal keratitis); PKP, penetrating keratoplasty; CI, corneal infiltration of unknown cause; FK, fungal keratitis.


Chest X-ray with left-sided pneumothorax and cervical subcutaneous emphysema.


(A) The patient's EEG after the first seizure in October 2020.


(B) The patient's EEG after the second seizure in October 2020. The pink box showed EEG becomes abnormal situation with sharp and slow waves.


Still picture of Supplementary Video S1 highlighting upper limb tremors and orofacial dyskinesias.


Axial magnetic resonance imaging (MRI) slice images of the brain: On admission:. T1-weighted contrast-enhanced (T1+C).


Axial fluid-attenuated inversion recovery (FLAIR) sequences illustrating contrast enhancement (white arrow) with sulcal hyper-intensity (black arrow) respectively.


Day 15:. T1+C.


FLAIR sequences illustrating resolution of MRI abnormalities.


The electroencephalography depicted a ss-rhythm, with an intermittently slow wave activity of 6-7/s. The independent component analyses showed a frontocentral topography (component 4, framed) compatible with tiredness.


Twenty-four hours of electrocardiogram showing signs of vegetative dysbalance with intermittent sinus tachycardia during daytime and sinus rhythm with stable frequencies during the night (presented are mean heart rates per minute). HF, heart rate; HFmax, maximum heart rate; HFmin, minimum heart rate.


Neuropsychological test results. t0 testing was performed before treatment, and t1 testing was performed 14 days after the steroid pulse treatment.


Colonies of
M. vaccae
 on a blood agar plate.


(A) Midsagittal MRI at age 3 showing no cerebellar changes at that time.


(B) Midsagittal MRI at age 11 showing evidence of asymmetric volume loss within the superior and middle components of the cerebellar vermis with preserved volume of the inferior component (red outline).


(C) Axial plane MRI exhibiting faint linear/T2 signal hypointensities within the Pons (red arrow).


Chromosomal microarray showing 1.422 megabase loss in the 13q12.12 region containing 14 different genes, including the SACS gene.


Chest radiographs of CMV pneumonia. (a) Initial chest radiograph with extensive right lung opacities, most prominent in the right middle lobe.


Chest radiographs of CMV pneumonia. (b) Chest radiograph on day 8 with an increase in right-sided infiltrates and new infiltrates at the left lung base.


Chest radiographs of CMV pneumonia. (c) Chest radiograph on day 22 with reduced infiltrates in the right lung field with a moderate overlying pleural effusion.


Transthoracic echocardiogram revealing a large pericardial effusion in the left parasternal long-axis.


Short-axis. View.


Chest CT images for case 2 showing a round-like mass shadow in the dorsal segment of the lower right lobe with a slight ground-glass opacity on the edge, a strip shadow in the local area of the left lower lobe, and an arc dense under the bilateral pleura on day 3 after symptom onset (A-D).


Chest CT images for case 5 showing bilateral scattered spots of shadows and consolidation in the upper right lobe on day 3 after symptom onset (A,B).


Time course depicting the clinical presentation of IgG4RD, laboratory results and treatment plans from 2009 to 2020. Chronic phase of the patient's disease: the upper part summarizes the specific features of clinical findings, biopsy, imaging, and immunological laboratory results; the lower part shows the therapy, specifying dose, duration, and dates for Rituximab infusions (deep red diamonds) and steroids (sky blue bars). Pulse treatment with methyl-prednisone (500mg i. v. ) is represented by the bottom scale blue bars and was usually followed by oral Prednisone (top scale blue bars); the dashed bar corresponds to the period when the patient did not adhere thoroughly to the prescribed therapy.


In the acute phase, the upper part shows the laboratory values for CFH (black, mug/ml), anti-CFH (pink, AU/ml), left y-axis, and thrombocytes (green, G/l) at the right y-axis. The normal reference values are shown with shades matching the colors of the different parameters. The lower part depicts the therapy including methylprednisolone/prednisone (sky blue bars, mg/d), plasma exchanges (deep blue arrows), and cyclophosphamide (purple triangles, 500 mg i. V. ). The time when TMA and COVID-19 were diagnosed are shown with symbols. AU, arbitrary units; BM, bone marrow; Covid-19; coronavirus disease 2019; CT, computed tomography; CTX, cyclophosphamide; HPF, high-power field; IgA, immunoglobulin A; IgG4-RD, immunoglobulin G4-related disease; i. V. , intra venous; PET-CT, positron emission tomography-computed tomography; PLEX, plasma exchange; RTX, Rituximab; SARS-CoV-2 severe acute respiratory syndrome coronavirus 2; TMA, thrombotic microangiopathy.


Identification of IgG4 anti-factor H autoantibodies: Plasma samples were analyzed for anti-factor H antibodies by a previously reported specific ELISA which was developed using Horse Radish peroxidase (HRP)-labeled secondary antibodies specific for human IgG, IgG4, and IgA, respectively. Data are shown as optic density at 490 nm (OD). (A) The patient's serum was tested in duplicates at different dilutions 1:100, 1:400, and 1:1,000 for both IgG (black bars) and IgG4 (grey bars). Controls included a normal human serum (NHS), a serum with known elevated anti-CFH IgG levels, and a serum with elevated IgG4 but no anti-CFH activity.


Light microscopy:. Glomeruli shows cellular crescents.


Glomeruli shows segmental necrotizing lesion.


EM: focal podocyte foot process effacement, no deposits, no tubuloreticular inclusions.


The chest CT showed nodules and patches in the upper lobe of the left lung on admission.


Enlarged lesions in the upper lobe of both lungs and bilateral pleural effusions were observed on the 13th day after admission.


Bilateral infiltrates, interstitial infiltrates, alveolar infiltrates and bilateral pleural effusion were observed on the 20th day after admission.


Yeast forms of Penicillium janthinellum in BAL washings stained with fluorescence. Original magnification X 400).


Gram stains. Original magnification X 1000).


Hexamine silver. Original magnification X 400).


Fungal morphology stained with medan lactate. Original magnification X 400).


Colony morphology in the obverse side was cultured in 28. C PDA medium for 5 days.


Colony morphology in the reverse side. Was cultured in 28. C PDA medium for 14 days.


(a) Skull CT in axial cut without contrast showing expansive frontal lesion with hyperdense margin with thinning of the frontal bone.


(b) Skull CT in axial cut with contrast showing contrast enhancement at the margin lesion.


Intraoperative picture.


CT axial cut postoperatively.


Transthoracic echocardiography preoperatively showing a giant biatrial mass with the size of 44.06 mm x 109.44 mm in the right atrium.


17.85 mm x 23.87 mm in the left atrium.


Color Doppler flow imaging showing severe mechanical hemodynamic obstacles in the right atrium primarily occupied by the giant tumor tissue.


Cardiac CT showing a biatrial mass with the atrial septum infiltrated.


Abdominal CT showing an angiomatous mass in the right posterior lobe of the liver (arrow) (transverse view).


Coronal.


Sagittal.


Plane; cardiac MRI showing a giant biatrial mass with tricuspid valve involved.


PET-CT showing a giant mass with increased glucose metabolism in the right atrium.


Intraoperative view of the tumor: right atrium was enlarged. With the tumor inside the chamber.


The right side of the tumor was visualized with the opening of the right atrium.


The biatrial mass together with the infiltrated septum was resected.


The biatrial mass together with the infiltrated septum was resected . The right atrial lesion was grossly composed of two parts. Arrows).


Immunohistochemistry post-operatively confirm the diagnosis of the cardiac myxoma with interstitial fibrous hyperplasia.


Hemorrhage , necrosis, and plasmacytes infiltrate.


Pedigree of the proband.


(a) Head CT scan showing diffuse and thick SAH on admission.


(b) 3D image of left IC angiography showing a paraclinoid aneurysm.


(c) The aneurysm was successfully obliterated with coiling.


(d) Head CT scan on day 3 showing most of the SAH was washed out.


Neuroimages obtained at the onset of deafness. (a) MR angiogram showing severe vasospasm in the right MCA and moderate vasospasm in the left MCA.


Neuroimages obtained at the onset of deafness. (b) DW image showing high signal intensity at the right insular cortex and the left superior temporal gyrus, indicating acute infarction due to vasospasm.


Neuroimages obtained at the onset of deafness. (c) ASL images show bilateral superior temporal gyri.


Clinical response to long-term immunotherapy and the effect of surgery. (A) Schematics showing the time line of patient's diagnosis, treatment and response.


Clinical response to long-term immunotherapy and the effect of surgery. (B) Computed tomography scans and Magnetic resonance imaging showing clinical response to immunotherapy and the effect of surgery.


Clinical response to long-term immunotherapy and the effect of surgery. (C) The result of PD-L1 staining before immunotherapy.


Clinical response to long-term immunotherapy and the effect of surgery. (D) PET-CT scan before Lung tumor resection. TC, paclitaxel+carboplatin; Pembro, pembrolizumab.


Examination of specific markers expression of ganglioneuroblastoma (case 1). A) Hematoxylin and eosin staining of the tumor sample (HE; 200x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). B) NB84 expression in the tumor (immunohistochemistry NB84; 400x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). C) Protein S100 immunoreactivity on the cells of the tumor (in this case ganglioneuroblastoma, S100; 400x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). D) CD56 also called neural cell adhesion molecule (NCAM) immunoreactivity on the ganglioneuroblastoma cells (CD56; 200x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). E) Positive expression of neuron specific enolase in the tumor sample (NSE) (NSE; 200x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). F) PGP9.5 expression in the tumor sample (PGP9.5; 200x).


CT of the abdomen - heterogeneous tumor with calcifications (70 x 70 x 100 mm) localized in retroperitoneal left space near left kidney (case 2).


Scarring alopecia over scalp.


Non-scarring alopecia was present over the pubic region.


Multiple follicular-oriented papules over the abdomen and trunk.


Optical coherence tomography of the lesions of the right.


Left. Eye showing choroidal lesions causing elevation of the retinal pigment epithelium and subretinal fluid.


Pedigree and clinical phenotype of proband. (A) Pedigree, with affected individual (the proband) in black and unaffected individuals in white. PIK3R1 genotyping of the pedigree identified a de novo mutation in the proband; WT, wild type.


Pedigree and clinical phenotype of proband. (B) Peripheral vasculitis of digits and heel.


Pedigree and clinical phenotype of proband. (C) Facial gestalt reminiscent of SHORT syndrome (short stature, hyperextensibility of joints and/or inguinal herniae, ocular depression, rieger anomaly of the eye, and teething problems): ocular depression, nasal deviation, and prominent mandible present in the proband (see main text and Supplemental Table 1).


Pedigree and clinical phenotype of proband. (D) Sanger sequencing confirmed a heterozygous splice site G/A mutation (black/green overlapping line) at position c.1425 + 1 of PIK3R1 gene in family member II-2 only.


Pedigree and clinical phenotype of proband. This mutation is absent (single black line corresponding to wild type "G" allele) in the other family members 1,. . 2, II-1, and II-3).


The timeline from the episodes of care of both patients.


Chest radiography images. Before.


After nine months of isoniazid treatment for the patient who progressed to active disease following the latent tuberculosis infection treatment.


Funduscopic appearance at 15-month follow-up showed relatively good retinal condition.


Sagittal.


Axial MRI of the lumbosacral spine revealed L1-L2 spondylodiscitis/osteomyelitis with a small, noncompressive anterior epidural collection and bilateral psoas muscle abscesses.


(a) Sagittal CT reconstructions of the lumbosacral spine demonstrate an extensive lytic process involving the L1 and L2 vertebral bodies. There is a significant involvement and narrowing of the L1-L2 disc space with endplate erosion.


Medical image.


MRI of the lumbar spine confirms CT findings and suggests L1-L2 spondylodiscitis. In addition, there is a progression of a large enhancing anterior epidural collection, which is compressing the thecal sac at L1-L2 and bilateral psoas muscle abscesses are demonstrated.


Cranial magnetic resonance axial section in sequence Standardized T1 weighted 3D Turbo Field Echo (sT1W 3D TFE).


Elbow and wrist flexors in paretic left upper limb in patient before being treated with incobotulinumtoxinA.


Postoperative X-ray of the right hip 4 days after operation.


8 years later . The X-ray 8 years later (B) was done in an external clincic, so unfortunately the complete endosprosthesis is not illustrated. The metaphyseal part shows no loosing. The patient is content and has no symptoms or complaints. Therefore, a current x-ray imaging is unnecessary.


Axial computed tomography study of the brain. . Notes: Minute cortical and subcortical calcifications located in bilateral frontal lobe.


Spin-Echo T2-weighted sagittal projections on magnetic resonance imaging study of the brain. . Notes: A "cobblestone" appearance is evident in the bilateral frontal opercular region.


Electroencephalogram showing diffusely deregulated cerebral electrical activity together with ubiquitous fast paroxysms, prevalent in the left temporal area.


Performing ERCP on a 73-year-old female patient presented with acute pancreatitis secondary to JPDD related CBD stone. (A) CT scan shows the inflammation and swelling of the pancreas and a mildly enlarged gallbladder. A diverticular pouch was present at the junction of second and third portions of the duodenum (yellow arrows).


Performing ERCP on a 73-year-old female patient presented with acute pancreatitis secondary to JPDD related CBD stone. (B) MRCP coronal haste thin slice image confirmed shows the presence of periampullary diverticulum, which causes extrinsic compression upon the CBD (yellow arrow). Note the possible CBD stone associated with dilation of the distal end of CBD.


Performing ERCP on a 73-year-old female patient presented with acute pancreatitis secondary to JPDD related CBD stone. (C) ERCP confirm the CBD stone and divericulum exerting compression upon the CBD outlet.


Performing ERCP on a 73-year-old female patient presented with acute pancreatitis secondary to JPDD related CBD stone. (D) The stone was successfully removed though the ERCP procedure.


(A-C) HCWs adhere to Level 2 biosafety requirement during the procedure. ERCP Endoscopy personnel precautions and dress code as follows: prior to ERCP procedure, the patient's status of COVID-19 was verified among the ERCP team. HCW wore PPE in the following order: respirator (N95, NK95, or the equivalent); impermeable gown; a first pair of gloves (over the impermeable gown that cover the wrist); lead aprons, thyroid shields, and dosimeters; boot covers; goggles and face shield; disposable isolation gown; and a second pair of gloves (over the isolation gown which cover the wrist). Washing hands with soap and water or alcohol-based hand rub were mandatory before and after patient interaction, contact with potentially infectious sources, and before putting on and upon removal of PPE.


The VNS device and an intraoperative photograph of the left vagosympathetic trunk. The pulse generator (width 45 mm, height 32 mm, depth 6.9 mm, and weight 16 g) (A).


The VNS device and an intraoperative photograph of the left vagosympathetic trunk. The electrode (B).


The VNS device and an intraoperative photograph of the left vagosympathetic trunk. The left vagosympathetic trunk wrapped by the two helical electrodes and anchor tether (C). VNS, vagus nerve stimulation.


The number of FS-GTCS and FS-GTCS clusters per month (A).


The number of FS and FS clusters per month (B).


The number of seizure days (FS-GTCS and FS) per month (C). The asterisk indicates that VNS therapy was initiated in this month. Months -5 to 0 indicate the retrospective period; months 1 to 12 indicate the follow-up period. FS-GTCS, focal seizures evolving into generalized tonic-clonic seizures; VNS, vagus nerve stimulation.


Cardiac magnetic resonance imaging included cine MRI (left column), native T1 mapping (middle column), and late gadolinium enhancement (LGE) imaging (right column) and demonstrated several myocardial metastases on the two-chamber views (green arrows) and three metastases in the four-chamber views (cyan arrows). The metastases were best seen on T1 mapping and cine MRI and had long T1 and T2 (not shown) relative to myocardium.


MRI-scan two days after symptom onset. Emerging white matter lesions with slight restricted diffusion but without Gadolinium (Gd) enhancement. T1 Gd-enhanced.


MRI-scan two days after symptom onset. Emerging white matter lesions with slight restricted diffusion but without Gadolinium (Gd) enhancement. T2-FLAIR (fluid attenuated inversion recovery).


MRI-scan two days after symptom onset. Emerging white matter lesions with slight restricted diffusion but without Gadolinium (Gd) enhancement. DWI (diffusion-weighted imaging).


MRI-scan 10 days after symptom onset. Progressive widespread white matter lesions with restriction in diffusion but still unaffected blood-brain-barrier. T1 Gd-enhanced.


MRI-scan 10 days after symptom onset. Progressive widespread white matter lesions with restriction in diffusion but still unaffected blood-brain-barrier. T2-FLAIR.


MRI-scan 10 days after symptom onset. Progressive widespread white matter lesions with restriction in diffusion but still unaffected blood-brain-barrier. DWI.


MRI-scan at 1-year follow-up visit. Markedly reduced white matter lesions. Right occipital hyperintensity on T2 reflects brain biopsy area. T2.


MRI-scan at 1-year follow-up visit. Markedly reduced white matter lesions. Right occipital hyperintensity on T2 reflects brain biopsy area. T2-FLAIR.


MRI-scan at 1-year follow-up visit. Markedly reduced white matter lesions. Right occipital hyperintensity on T2 reflects brain biopsy area. DWI.


Anti-NMDA receptor antibodies in patient's cerebrospinal fluid and serum. Anti-NMDA receptor antibodies were positive in cerebrospinal fluid (IgG, 1:32) ,serum (IgG.


Anti-NMDA receptor antibodies in patient's cerebrospinal fluid and serum. 1:320). Before immunotherapy.


Anti-NMDA receptor antibodies in patient's cerebrospinal fluid and serum. 1:32). After 5 months of immunotherapy. . Abbreviation: NMDA, N-methyl-D-aspartate.


Marked mixed pulmonary pattern with diffuse radiographic lesions in a 7-month-old Miniature Poodle presented with respiratory decompensation while receiving appropriate antimicrobials. Right.


Marked mixed pulmonary pattern with diffuse radiographic lesions in a 7-month-old Miniature Poodle presented with respiratory decompensation while receiving appropriate antimicrobials. Left lateral radiographic projections showing bilateral diffuse lesions characterized by marked diffuse small airway thickening (white arrow), peribronchial cuffing and multifocal alveolar pattern (*) with air bronchograms (arrowheads). Incidentally, intra-thoracic tracheal luminal diameter (doubleheaded arrows) varied on average 28% between both lateral projections suggesting dynamic tracheal collapse. The tracheal bifurcation and principal bronchus were narrowed on the left lateral projection.


Marked mixed pulmonary pattern with diffuse radiographic lesions in a 7-month-old Miniature Poodle presented with respiratory decompensation while receiving appropriate antimicrobials. (C) On the ventrodorsal projection, the left cranial lung lobe is completely opacified (*) and the cardiac silhouette is shifted to the left (long horizontal arrow). The lesions are centered around the lobar and segmental bronchi (short arrows) and decrease in severity toward the periphery. The left caudal lung lobe (LCd; flared arrows) is the second most severely affected lobe after the left cranial lobe.


Transverse (3 mm-thick) computed tomographic (CT) images of a Miniature Poodle obtained at 9 months. Using a single slice CT).


8 years. Using a 64-detector row CT) of age displayed from the same level side by side. On the first study, the left cranial lung lobe (single opened arrow) is completely collapsed with almost complete absence of air in the airways. The caudal branch of the left cranial lobar bronchus is narrowed but filled with air (ventral to opened arrow on C). The left caudal lung lobe is also severely reduced in volume and thus, increased in attenuation with several air-filled end on airways (double arrows). The right lung is hyperinflated with the right cranial (RCr) and accessory (RAcc) lobes extending to the left of midline. Mosaic pattern characterized by a well circumscribed hypoattenuating area is seen in the accessory lobe (arrowhead). The parenchyma is otherwise relatively normal. By 8 years of age and after undergoing left cranial lobectomy as a puppy, the entire hyperinflated right lung has developed severe patchy parenchymal lesions consisting of ground-glass opacification (black arrows) and consolidation (*). This latter is most severe surrounding medium- to large-caliber dilated airways. Traction bronchiectasis (black arrowheads) in areas of architectural distortion is seen at the periphery of several of these airways, a common feature seen with pulmonary fibrosis. The mosaic pattern previously recognized in the accessory lobe (white arrowheads) is accentuated. Several cystic air-filled structures (white arrows) of varying size occupy the left caudal lobe.


Five years post left cranial lobectomy, radiographic lesions were still present especially in the left caudal lung lobe of a 6-year-old Miniature poodle. (A) Left lateral projection showing several areas of increased opacity in the cranioventral, caudoventral and caudodorsal lung field (arrows). In the caudodorsal lung field, a large bronchus (arrowhead) is dilated and does not taper as it extends toward the periphery indicating bronchiectasis. In the more severe opacified areas, small air bronchograms are seen (white arrow).


Five years post left cranial lobectomy, radiographic lesions were still present especially in the left caudal lung lobe of a 6-year-old Miniature poodle. (B) Right lateral projection revealing radiographic lesions (black and white arrows) similar to those on the left and most prominent in the caudodorsal lung field. They are less extensive in the ventral aspect of the thorax in comparison to the left lateral view. Note that some lesions maybe less distinct due to motion artifact.


Five years post left cranial lobectomy, radiographic lesions were still present especially in the left caudal lung lobe of a 6-year-old Miniature poodle. (C) As expected following left cranial lobectomy, leftward mediastinal shift remains visible (black arrow) on the ventrodorsal projection. The borders of the left caudal lobe appear retracted (arrowhead) and the lung lobe is increased in opacity. Lesions are most severe centrally and less extensive toward the periphery. Similarly, radiographic opacity is increased (white arrows) surrounding major lobar structures (vessels and bronchus) of the right lung and gradually diminish in periphery of the lung.


Chest computed tomography, showing perihilar consolidations at both sides with underlying bronchiectasis. In the periphery of the lungs smaller nodular infiltrates are visible. These are indicated by the arrows.


Microscopy after kinyoun staining of
M. microti
 in culture. This culture became positive after 75 days of incubation. The microscope used was a Zeiss Axioskop, the magnification x100.


Computed tomography of the left hip, showing bone destruction of the anterior side of the collum. Next to this site, multiple fluid collections are visible, which are highly suspicious for abscesses. These collections infiltrate in the adjacent muscles. The largest collection in this view measures 64.5 by 37.1 mm and has a very thick wall.


Pathological findings. Brain biopsy from the left frontal lobe. (A) Hematoxylin and eosin staining.


Pathological findings. Brain biopsy from the left frontal lobe. (B) CD20 immunohistochemical staining.


Pathological findings. Brain biopsy from the left frontal lobe. (C) Ki-67 immunohistochemical staining.


Pathological findings. Brain biopsy from the left frontal lobe. (D) CD3 immunohistochemical staining.


Contrast-enhanced brain MRI recorded 1 month after brain biopsy shows a spotty gadolinium enhancement in the left periventricular white matter (arrow) and post-biopsy scar (arrowhead).


With T2 hyperintensities.


(C) This lesion does not show abnormal hyperintensities on diffusion-weighted imaging (DWI).


Peripheral blood smear showing multiple areas of red blood cell agglutination (arrows).


Ultrasound and contrast-enhanced computed tomography (CT). (A) Ultrasound at first visit (Day 1): a 1-cm low echo cyst-like region in the right kidney (arrowhead).


Ultrasound and contrast-enhanced computed tomography (CT). (B) First contrast-enhanced CT (Day 36): the kidney is enlarged. Poorly enhanced masses with enhanced borders were found in both kidneys (arrowhead). Two to three patchy poorly contrasted areas were found in both kidneys, but it was difficult to identify if they were cysts or infectious lesions (arrow).


Magnetic resonance imaging (Day 60). (A) T2-weighted images: 2-mm high-signal small patchy shadows were found in both kidneys (arrow).


Magnetic resonance imaging (Day 60). (B) T2-weighted images: thick walls in the right kidney as low signals and mass as high signals were found in the interior (arrowhead). Diffusion-weighted images: masses as high-signal areas of thick-walled structures at the same site as. (arrowhead). Apparent diffusion coefficient (ADC) map: low-signal mass at the same site as. (arrowhead).


Magnetic resonance imaging (Day 60).


Magnetic resonance imaging (Day 428). (A) Diffusion-weighted images showed that the mass with high-signal areas of thick-walled structures disappeared (arrowhead).


Magnetic resonance imaging (Day 428). (B) Low-signal masses are also not visible on apparent diffusion coefficient (ADC) map (arrowhead).


Pruritic follicular papules over back.


(a) On dermoscopy the hairs were seen like loops.


(b) Solid papules over back seen on dermoscopy.


(a) Hairs coming out of the skin and again re-entering.


(b) Solid papules had bend hairs inside.


Coiled up strongyloides larvae.


Double bulb esophagus.


Primordial genital primordium.


Embryonated egg.


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. Biopsy of a cervical lymph node performed on day +36 showed effacement of the architecture due to numerous granulomas (low magnification.


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. , which were composed of epithelioid cells.


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. Between the granulomas a polymorphous lymphoid infiltrate was noted containing blasts as well as plasma cells (c).


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. The blasts were latently EBV-infected as shown in the immunohistochemical demonstration of EBNA2 (d).


Radiological diagnosis of disseminated tuberculosis. CT scan of the thorax on day +43 after allogeneic stem cell transplantation revealed a borderline sized mediastinal lymph node with central necrosis.


Radiological diagnosis of disseminated tuberculosis. As well as multiple pulmonary nodules.


Histopathological examination of the papule (HE; x100).


Expression of CD63 on basophils in Patient 1, an atopic control, and a non-atopic control, after incubation with American and Korean ginseng.


CT showing infected aneurysm of the splenic artery (arrow) with complete distal obliteration.


The spleen showing multiple large purulent loculations (arrows).


Timeline of symptoms, diagnostic, interventions, and outcomes.


Shoot from brain MRI of May 8 in :. Show T2-FLAIR acquisition.


Shoot from brain MRI of May 8 in (C) Shows occipital lesion in T2-FLAIR acquisition.


Shoot from brain MRI of May 8 in (D) Shows parietal lesion in T2-FLAIR acquisition.


Shoot from brain MRI of May 8 in (E) Shows occipital lesion positive in DWI.


Shoot from Brain MRI of June 16: (F,G) show T2-FLAIR acquisition.


A; Chest CT on February 6, 2018 (before the administration of SOF/VEL), showed pleural effusion in the lower part of the right lung. The white arrows show pleural effusion.


B; Abdominal CT on February 6, 2018 (before the administration of SOF/VEL), showed ascites in the lower part of the liver. The white arrows show ascites.


A; Chest CT on September 25, 2019 (after the administration of SOF/VEL), showed that the pleural effusion in the lower part of the right lung had disappeared completely.


B; Abdominal CT on September 25, 2019 (after the administration of SOF/VEL), showed that the ascites in the lower part of the liver had disappeared completely.


Time course of serum ammonia level after SOF/VEL administration.


Time course of serum albumin level after SOF/VEL administration.


(A) Erythema and lots of tiny pustules on the abdomen.


(B) Many pustules on the basis of erythema on the lower abdomen.


(A) Lots of tiny pustules on the trunk.


(B) Many tiny pustules and some scales on the upper limbs.


Timeline of the case after admission. (A-C) Time course of CK, myoglobin, plasma creatinine, and levels of uPCR and uACR.


Timeline of the case after admission. (D) Time of treatment regimens and kidney biopsy. CK, creatinine kinase; CYC, cyclophosphamide; uACR, urinary albumin-to-creatinine ratio; uPCR, urinary protein-to-creatinine ratio.


Histopathological findings in a kidney biopsy confirming pauci-immune crescentic GN. Representative photomicrographs of the kidney biopsy including staining for IgA (scale bar: 50 mum), IgG (scale bar: 50 mum), IgM (scale bar: 50 mum), C1q (scale bar: 50 mum), and C3c (scale bar: 50 mum); periodic acid-Schiff staining showing a glomerulus with crescent formation (scale bar: 50 mum); and hematoxylin/eosin staining with myoglobin casts (asterisks, scale bar: 100 mum) and tubulointerstitial inflammation with prominent eosinophilic infiltration (scale bar: 100 mum). C1q, complement component 1q; C3c, complement factor 3 conversion product; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; GN, glomerulonephritis.


Concurrent CRRT, VA-ECMO and TPE. O2, oxygen, CO2, carbon dioxide, others as per Figure 1.


A-c Slit-lamp photographs on POD 5 (1 day after flap lift and irrigation). A; Right eye with improving peripheral keratolysis.


B; High magnification of peripheral keratolysis in the left eye.


C; Left eye with persistent peripheral keratolysis.


E Photographs at postoperative month 6, showing resolved keratitis with mild peripheral stromal scarring in the right eye. And left eye.


Electron microscopy of the renal biopsy showing subepithelial membranous deposits (arrow) and adjacent foot process effacement (description courtesy of John Higgins, MD, and Christina Kong, MD, Department of Pathology, Stanford University School of Medicine, Stanford, Calif. , USA).


Course of body temperature and clinical events. . Notes: Pyrexia was not seen on the day of admission. On postoperative day 2, body temperature suddenly rose. Thereafter, pyrexia was controlled with daily administrations of acetaminophen. Three days after discharge, severe pain in both shoulders and morning stiffness suddenly occurred. Body temperature was controlled by daily acetaminophen administration and remained normal after switching to prednisolone. . Abbreviation: P, prednisolone; URTI, upper respiratory tract infection.


Head computed tomography images of a 64-year-old man with asymptomatic symptom for coronavirus disease 2019. (a) Axial showing subarachnoid space dilated associated with cortical atrophy (Red arrows).


Head computed tomography images of a 64-year-old man with asymptomatic symptom for coronavirus disease 2019. (b) Choroid plexus calcification in the lateral ventricles (Red arrows).


Chest computed tomography (CT) images of a 64-year- old man with asymptomatic symptom for coronavirus disease 2019. Axial plane chest CT scans showing lymph nodes larger than 1 cm (Red arrows).


Erythematous and maculopapular rashes on the upper and lower extremities.


Sagittal T1-weighted magnetic resonance imaging (MRI) of the brain with gadolinium contrast. A) Preoperative image demonstrates a 2.6 x 1.6 cm enhancing mass with surrounding edema.


Sagittal T1-weighted magnetic resonance imaging (MRI) of the brain with gadolinium contrast. B) Axial diffusion-weighted MRI demonstrating perilesional edema but no solid areas of restricted diffusion to suggest abscess.


Sagittal T1-weighted magnetic resonance imaging (MRI) of the brain with gadolinium contrast. C) Postoperative image one day after surgery demonstrating gross total resection.


Sagittal T1-weighted magnetic resonance imaging (MRI) of the brain with gadolinium contrast. D) Postoperative image four months after surgery showing no recurrence.


Intraoperative images of tumor. Superficial mass with well defined margins and surrounding normal brain tissue.


Intraoperative images of tumor. Resection cavity.


Pathological examination of tumor. A) Hematoxylin and eosin staining show necrotizing granulomas with peripheral palisading epithelioid histiocytes, giant cells.


Pathological examination of tumor. B) Acid fast bacillus.


Chest computed tomography on admission of an asymptomatic 64-year-old woman infected with severe acute respiratory syndrome coronavirus-2. Ground-glass opacities were observed in the peripheral areas under the pleura on the right lower lobe (posterior basal).


Photographs of the anterior eye of the patients before and after treatment. A, b Case 1. A; A brown pigmented infiltrate in the paracentral cornea with few satellite lesions in the superior peripheral cornea 1 week after cataract surgery.


Photographs of the anterior eye of the patients before and after treatment. B; The corneal ulcers developed into scars after the treatment.


Photographs of the anterior eye of the patients before and after treatment. C, d Case 2. C; A corneal infiltrate with central brownish pigments on top of the lesion at presentation.


Photographs of the anterior eye of the patients before and after treatment. D; Scar tissue and vascularization replaced the corneal ulcer, with small foci of epithelial defects remaining after 1 month of treatment.


A; Potassium hydroxide preparation showing numerous dark septate fungal hyphae. Magnifications: x400.


B; Numerous fungal elements detected on calcofluor white staining. Magnifications: x400.


C; Microscopic analysis of b showing fungal hyphae and conidia. X100.


D; Dark pigmented colonies of F. Pedrosoi growing on Sabouraud's dextrose agar.


Results of Sanger sequencing of BLM of the proband. The red arrows indicate the c.1544delA (p. Asn515Metfs*16) (A) and c.692T>G (p.


Results of Sanger sequencing of BLM of the proband. The red arrows indicate the c.1544delA (p. Leu231*) (B) heterozygous variants.


Family pedigree. Filled black symbols represent individuals with diabetes. The red arrow indicates the proband.


Parotid fistula and Frey's syndrome.


The parotid region is divided into four quadrants. The injection points are at 1 cm from each other.


Intra-operative condition of the lesion located at middle of upper clivus region. The lesion was very tough, and ,firm (the arrow).


Intra-operative condition of the lesion located at middle of upper clivus region. The lesion was stick to the brain stem and basal artery (1: brain stem; 2: basal artery; 3: abducent nerve).


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Hematoxylin, and . Eosin (H&E) stain showed the lesion was composed of sclerosing fibrosis associated with dense lymphoplasmacytic infiltration. X40.


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Hematoxylin, and . . X100).


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Immunohistochemical analysis revealed over 400 IgG4-positive cells per high-powered field, and . A high IgG4/IgG ratio. IgG, x200.


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Immunohistochemical analysis revealed over 400 IgG4-positive cells per high-powered field, and . . IgG4, x200).


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Immunohistochemical staining of CD38. Immunohistochemical staining of Ki-67.


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. (F) Immunohistochemical staining of Ki-67.


Chest radiography revealed consolidation in the right lower lung field at the initial visit.


Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


X-ray pelvis showing reduced joint space with destruction of ischial tuberosity, acetabulum, and femoral head (arrowhead).


Hematoxylin and eosin staining (x10 objective): intense inflammatory response and giant cell reaction against lamellated membranes (arrowhead).


Hematoxylin and eosin staining (x40 objectives): Giant cell reaction against lamellated membranes (arrowhead).


Magnetic resonance imaging of the patient's brain. . Notes: (A) A T2-weighted image showing hyperintensity lesions (arrows) in the temporal lobes and left occipital lobe.


Magnetic resonance imaging of the patient's brain. (B) Multiple hyperintensities (arrows) in the temporal and parietal lobes and demyelination in the white matter surrounding the lateral ventricles revealed by the fluid-attenuated inversion recovery sequences.


Magnetic resonance imaging of the patient's brain. (C) A susceptibility-weighted image showing a low signal (arrow) in the right frontal lobe.


The electroencephalogram of the patient showing slow-waves characterized by strong peaks of delta (delta) and theta (theta) frequencies in the right frontal lobe. . Note: The arrows point to slow-waves from the Fp2-C4 and Fp2-L4.


Multiplex PCR. The present strain harbored iutA, rmpA, entB, and mrkD genes.


The patient developed ptosis, opthalmoplegia, chemosis, pupillary dilatation, and loss of sensation over the left eyelid in the immediate postoperative period.


Three months after the surgery, there was partial recovery of ptosis and opthalmoplegia.


Abduction of the left eye has not recovered in three months.


Three months after the surgery, chemosis is still present while opthalmoplegia has partially recovered.


Brain computed tomography scan of case 2. (A) The CT images show blocking of the right lateral ventricle but with obvious enlargement of the left lateral ventricle and the fourth ventricle, which indicate separation of the ventricular system.


Brain computed tomography scan of case 2. (B) Red arrow show the drainage tube.


RE. Macula with cotton wool spots, and ,minor microangiopathy signs temporal from the fovea.


FFA temporal periphery highlighting an area of ischemia bordered by neovascularisation.


FFA superior with microangiopathy.


Plain CT.


Contrast-enhanced scan. Of the kidney. The arrow shows a mass of 5.5 x 5.0 x 4.0 cm on the left side.


A pathological study of the mass on the left kidney confirmed it as renal cell carcinoma, clear cell type. (A) Low magnification.


A pathological study of the mass on the left kidney confirmed it as renal cell carcinoma, clear cell type. (B) High magnification. The cells have a clear cytoplasm, surrounded by a distinct cell membrane, and contain round and uniform nuclei.


Image of subconjunctival hemorrhage.


Toraks ct of first hospitalization day.


Toraks ct of third hospitalization day.


2D echo PLAX view showing subaortic membrane with marked left ventricular hypertrophy, and ,mild pericardial effusion.


2D echo PLAX view showing vegetation on anterior mitral leaflet, measuring 10 x 6 mm.


MRI brain axial section showing hypointense signal intensity alteration on T1WI.


Hyperintense on T2 FLAIR. In left parietal region, suggestive of acute infarct. There is also perilesional edema.


Changes of rectal ulcer on colonoscopy before.


After. Antiviral treatment.


The Genotype Mycobacterium CM (HAIN Lifescience) hybridization pattern for isolates from blood and pus samples (strip 3 and 4 from the top) with template (strip 1) for evaluation. Band 1 (CC): conjugate control; band 2 (UC): universal control; band 3 (GC): genus control; bands 5, 6, and 10: probes specific for M. abscessus.


FA of the patient's right eye taken over a 2-year period. . Notes: (A and B) Initial visit (early phase of FA of the right eye reveals a small irregular hyperfluorescence area inferonasal to the fovea with late-phase leakage that corresponds to the juxtamacular CNV lesion; arrows).


FA of the patient's right eye taken over a 2-year period. (C and D) One week after cessation of steroid therapy (a fulminant recurrence and development of CNV membrane with involvement of the fovea; arrows).


FA of the patient's right eye taken over a 2-year period. (E and F) Three months after PDT (progressive enlargement of CNV membrane).


FA of the patient's right eye taken over a 2-year period. (G) Recurrent activity of CNV membrane 8 months after the second intravitreal ranibizumab injection (circle).


FA of the patient's right eye taken over a 2-year period. (H) Two months after periocular triamcinolone injection combined with intravitreal ranibizumab injection (almost complete regression of active CNV membrane). . Abbreviations: CNV, choroidal neovascular membrane; FA, fluorescein angiography; PDT, photodynamic therapy.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (a) Lesions growing on the elderly patient's scalp resembled pustular erosions with eschars.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (b) Assuming an infectious origin, some lesions were detached successfully (indicated by an arrow) by using a gauze soaked with a 1 % NCT solution. Tissue and swabs were collected and sent for microbial culture.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (c) On day 3, treatment with 1 % NCT showed visible but slow regression of the lesions. Combination therapy with 1 % NCT and 1 % NBrT was commenced.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (d) The next day (day 4), the 1 % NCT and 1 % NBrT combination treatment had accelerated the regression and softening of the lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (e) By the fifth day of treatment, lesions together with a subcutaneous portion of skin could be partly removed without serious bleeding. Application of 0.1 % BAT twice daily was commenced at home.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (f) Evident accelerated tissue repair and almost total clearance of remaining lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (g) Wounds were epithelialized, with no evident recurrence of lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (h) Further epithelialization of the wounds from the previous lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (i) Remarkable epithelialization and tissue repair induced the decision to end the treatments at the clinic.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (j) The skin was completely epithelialized and returned to normal pigmentation. Application of 0.1 % BAT was stopped.


CT Scan without contrast of the left lower extremity indicating the mass (red arrow).


MRI without contrast of the hip showing the fluid collection around left hip joint (red arrow).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. , Timeline showing absolute CD4 and CD8 T cell counts, including effector-memory subsets and NK cell counts (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. Absolute B cell counts (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. , Anti-SARS-CoV-2 S protein IgG, IgA and IgM antibody levels as assessed by an in-house developed Luminex assay for each plasma The cytopathic effect on VeroE6 cells was evaluated after inoculation with SARS-CoV-2 from nasopharyngeal swabs: C+, successful virus isolation; C-, absence of virus isolation. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. As well as in the patient's serum before and following plasma transfusions (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. (E), Activity of neutralizing antibodies was assessed by a SARS-CoV-2 pseudovirus neutralization assay for each plasma and in patient's serum at different time-points. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. (F), Over-time follow-up of SARS-CoV-2 RNA detection in nasopharyngeal swabs. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Computed Tomography of chest, abdomen, and pelvis of patients 1, 2, and 4. (A) Patient 1: splenic nodule indicated by arrow.


Computed Tomography of chest, abdomen, and pelvis of patients 1, 2, and 4. (B) Patient 1: right sided pulmonary lesion indicated by arrow.


Computed Tomography of chest, abdomen, and pelvis of patients 1, 2, and 4. (C) Patient 2: hepatosplenomegaly.


Computed Tomography of chest, abdomen, and pelvis of patients 1, 2, and 4. (D) Patient 4: right upper lobe pulmonary lesion.


Chest X-Ray of a 3-months-old boy with Pre-XDR TB. It shows infiltrate at the upper-middle right lung field with an increased of bronchovascular marking.


Chest X-Ray of a 14-years-olf girl with Pre-XDR TB. It shows opacity at the right hilar, lobulated infiltrate in the left apex, nodular at left hilar, and lymph node enlargement at bilateral peri-hilar.


A: Bowel perforation at the cecum.


B: Bowel perforation at the terminal ileum.


C: Laparotomy wound at the postoperative period.


Facials features of the patient. Our patient expressed the typical facial phenotype comprising epicanthus, midface hypoplasia, flat nasal bridge, small triangular nose with anteverted nostrils, carp-shaped mouth with full lips, and dental diastema at age 6 months.


Facials features of the patient. And 3 yr.


Photomicrograph of the peripheral blood of our case with ATR-X syndrome. It shows cells containing HbH inclusions in our patient.


Photomicrograph of the peripheral blood of our case with ATR-X syndrome.also his mother.


Photomicrograph of the peripheral blood of our case with ATR-X syndrome. And eldest sister.


Patch test results (after 48 h):. Positive reaction to para-aminosalicylic acid.


Positive reaction to prothionamide.


Computed tomography scan image: the subdural collection is increased in dimension with a higher density in the posterior part by persistent midline brain shift.


Postsurgical computed tomography scan control shows the evacuation of the collection with air in the anterior part and a reduction of midline brain shift.


Ultra-wide field color fundus photograph of the right and left eye depicting diffuse midperipheral chorioretinal atrophy with sparing of the central macula. . Note: The left eye also has central submacular fibrosis.


Fluorescein angiogram (FA) transiting the left eye reveals diffuse atrophy of the choriocapillaris sparing the central macula. . Notes: A central hyperfluorescent lesion in the early images stains (00:29) in the late angiographic images centrally (04:28) (arrowhead). Mild leakage is apparent nasally (arrow).


Saline wet mount showing bile stained, thick walled egg with hexacanth embryo and without polar filaments.


Percutaneous pigtail drain at the right lower abdomen.


Cystoscopic view of a small perforation at the posterior wall of bladder.


Retrograde cystography showing no contrast extravasation. Filling phase.


Retrograde cystography showing no contrast extravasation.


Retrograde cystography showing no contrast extravasation. Voiding. Post voiding film.


Macroglossia and elfin features.


Marked acanthosis nigricans and hirsutism, distended abdomen.


Rough skin (upper extermities).


Rough skin (lower extremities).


Crowding of teeth, hyperplastic gingiva.


Postoperative picture, extraction of the offending teeth.


Bone Marrow aspirate smears, Wright-Giemsa Stain 1000X.


FISH characterization of double heterologous Robertsonian translocations. Bone marrow metaphase hybridized with fluorescent DNA probes for 15q22 (PML green), 15q11.2 (SNRPN orange), Cen15 (alpha satellite aqua), chromosome 14q32 (5'IGH green, 3'IGH orange) and chromosome 13q14(RB-1 green). Note the absence of a normal chromosome 14.


Timeline of the patient's clinical course after cardiac surgery.


Vertebral magnetic resonance imaging of the vertebral lesions. Vertebral magnetic resonance imaging revealed lesions of the vertebral bodies at T8-T9-L4-L5-S1 and invertebral disks between T8-T9.


Vertebral magnetic resonance imaging of the vertebral lesions. L4-L5-S1 , with an epidural abscess of 5 cm at the L3 and L4 levels, consistent with a pyogenic vertebral osteomyelitis.


99mTc-methylene diphosphonate bone scintigraphy showing diffusely increased left rib cage uptake (anterior a, posterior b; arrows). Transaxial single photon emission computed tomography (SPECT) and SPECT/CT images (c, e; arrows) show diffusely increased radiotracer uptake involving the left-sided ribs.


99mTc-methylene diphosphonate bone scintigraphy showing diffusely increased left rib cage uptake (anterior a, posterior b; arrows). Transaxial CT (bone window, d) shows normal left-sided ribs with regular cortical outlines.


99mTc-methylene diphosphonate bone scintigraphy showing diffusely increased left rib cage uptake (anterior a, posterior b; arrows). Transaxial CT (soft tissue window,. Shows a pleural-based soft tissue density lesion in the left lung lower lobe. Arrow head) with diffuse circumferential pleural thickening. Arrow).


Plain pelvic X-ray showing prostatic urethral calculus.


Micturating cystourethrogram (MCUG) showing huge prostatic cavity.


Petechial rash found in the distal third of the legs and the feet.


Petechial rash on buccal mucosa.


Demonstrating nail ridging.


EKG showing ST segment elevations in leads II, III, and aVF.


Course of CA 19-9 level. PD = Progressive disease; nab-paclitaxel = nanoparticle albumin-bound paclitaxel.


Midline rudimentary uterus (black arrow) with fallopian tube on both sides. Both gonad at the two ends, vas can be identified (indicated by forceps tip) along the vascular pedicle. Line diagram (inset) showing the anatomical details of the case. (u = uterus, v = vagina, F. T. = fallopian tube, T = testis, dotted line showing vas deferens).


Excised uterus (blue arrow) along with the bilateral fallopian tube. Both testis separated (black arrows) from the Mullerian remnants.


Distal most part of the rudimentary vagina, the vaginal cavity opened (black arrow) to remove the mucosa.


Photomicrographs. X100,. Papanicolaou Stain) show epithelioid cells. Arrow).


With pale elongated oval shaped cells. X200,. Papanicolaou Stain) showing slipper or sole of the foot shaped nuclei. Inset).


Computed tomography (CT), chest. Disseminated atypical pulmonary infiltrates (day +145 after alloHSCT).


Computed tomography (CT), chest. Chest CT following antimycotic therapy (day +170).


Computed tomography (CT), chest. Disease progression after three courses of rituximab, and ,two courses R-CHOP (day +228).


Computed tomography (CT), chest. Complete remission (CR) after five courses of brentuximab vedotin and three courses of third-party EBV-specific T-cells.


Histopathology and immunohistochemistry of pulmonary tumor biopsies. AlphaCD20.


Histopathology and immunohistochemistry of pulmonary tumor biopsies. MiB1.


Histopathology and immunohistochemistry of pulmonary tumor biopsies. AlphaLMP1.


Histopathology and immunohistochemistry of pulmonary tumor biopsies. AlphaCD30.


Nocardial brain abscess. On the 18th day after admission, diffusion weighed axial MRI of our patient detected brain abscesses. The lesion had mixed signal intensity with hypointense capsule surrounded by high signal edema zone.


Comparison of cross-sectional chest CT images obtained from the patient at different time points. A1-4 October 5th, 2020: The day of admission; B1-4 Eighth day after admission on October 13th, 2020; C1-4 October 22nd, 2020 The day of discharge; D1-4 November 14th, 2020 20 days after discharge; E1-4 February 6th, 2021 Nearly 4 months after discharge.


A flow chart describing the patient diagnosis process.


Clinical photograph of the left eye following corneal tear repair with fibrin glue. Note the central large wound.


A: CT scan image after the initial surgery showing a round, 1.9 mm x 2.1 mm sized radio dense (400 Hounsfield Units) lesion close to the retina in the left globe.


B: CT scan following aspiration of the PFCL bubble showing the absence of any radio dense lesions.


A single axial image from a Thoracic Computed Tomography (CT) scan acquired on Day 110 in a leukaemic patient with Invasive Pulmonary Aspergillosis (IPA). A 4 mm endobronchial valve (Zephyr , Pulmonx Inc. Neuchatel, Switzerland) is demonstrated within the lingular segmental bronchus proximal to an alveolar-pleural fistula caused by rupture of a fungal mass lesion. There has been a significant improvement in the previously demonstrated left-sided pneumothorax.


Images of CT scan of chest obtained from 2 year old child with empyema. A) Large pleural effusion with resulting left lower lobe compressive atelectasis.


Images of CT scan of chest obtained from 2 year old child with empyema. B) Left upper lobe consolidation with air bronchogram.


Clinical phenotype in a patient with NF-kappaB1 deficiency. (A) Skin biopsy showing a dense cellular infiltrate by Langerhans cells. Magnification 200x.


Clinical phenotype in a patient with NF-kappaB1 deficiency. Hematoxilin-eosin; (B) Skin biopsy with Langerhans cells infiltrating epidermis and subcutaneous tissues, positive to CD1a. Magnification 200x.


Clinical phenotype in a patient with NF-kappaB1 deficiency. Immunohistochemistry CD1a; (C) Panoramic view of bone marrow with many histiocytes with granular cytoplasm. Magnification 40x. Inside images: high power view of histiocytes between hematopoietic cells. They were intensely positive with acid-alcohol techniques (Ziehl Nielsen). Magnification 400x.


Clinical phenotype in a patient with NF-kappaB1 deficiency. Hematoxilin-eosin and Ziehl Nielsen; (D) Panoramic view of duodenal biopsy with villi shortened and lamina propria expanded by many granular histiocytes that stained positive with Ziehl Nielsen to detect Acid-resistant bacilli (inside). Magnification 200x. Hematoxilin-eosin. Inside Ziehl-Nielsen.


Clinical phenotype in a patient with NF-kappaB1 deficiency. Magnification 200x (E) Post-contrast coronal T2-weighted MRI of the abdomen showing mesentery enhancement.


Clinical phenotype in a patient with NF-kappaB1 deficiency. (F) Small bowel biopsy showing myenteric plexus with lymphoplasmocitoid inflammatory cells. Magnification 200x.


The glomerulus reveals features of collapsing glomerulopathy, with epithelial cell proliferation and collapse of underlying capillary walls. Tubules reveal flattening of the epithelium, distension of lumens, and focal intraluminal accumulation of cellular debris (periodic acid-Schiff stain, x 200).


Kinetics of PB19 viremia from detection to 6 weeks after transplantation.


A magnified view of viral loads of PB19 (notice the Y axis difference) from the initiation of the second course of intravenous immunoglobulin IVIg = intravenous immunoglobulin 500 mg/kg (gray dot); CDV = cidofovir 0.5 mg/kg (blue dot); dotted line = day of transplantation.


A computed tomography scan of the brain that shows the patient's initial acute subdural hematoma before surgery.


After evacuation.


A computed tomography scan of the brain that shows the patient's recurrent acute subdural hematoma.


After the second evacuation.


Chest CT scan of COVID-19 pneumonia (first chest CT scan). Axial sections of the chest CT scan at different levels show bilateral ground-glass opacities and consolidation images that are bilateral, subpleural, and located mainly in posterior regions (A-C).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). The chest CT scan performed 4 weeks after the management of severe COVID-19 pneumonia reveals the appearance of bronchiectasis. Green arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). The chest CT scan performed 4 weeks after the management of severe COVID-19 pneumonia reveals the appearance of bronchiectasis. Green arrow),. Fissure deformity. Orange arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Paracicatricial emphysema. Red arrow), and . Cavitation in the right middle lobe. Black arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Paracicatricial emphysema. Red arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Subpleural reticulations. Blue arrow),. Lobular distortions. Violet arrow).


Post-corticotherapy chest CT scan (third chest CT scan). The chest CT scan performed after 3 months of corticotherapy of post-COVID-19 symptoms reveals the regression of ground-glass lesions and bronchiectasis, and the persistence of paracicatricial emphysema (A-C).


Post-corticotherapy chest CT scan (third chest CT scan). The chest CT scan performed after 3 months of corticotherapy of post-COVID-19 symptoms reveals the regression of ground-glass lesions and bronchiectasis, and the persistence of paracicatricial emphysema (A-C). (B-D) Show the disappearance of the cavity image of the right middle lobe, the regression of retraction signs, and the persistence of few reticulation lesions.


Post-corticotherapy chest CT scan (third chest CT scan). (B-D) Show the disappearance of the cavity image of the right middle lobe, the regression of retraction signs, and the persistence of few reticulation lesions.


Chest X-ray showing multiple cysts.


Axial contrast-enhanced CT images show multiple omental nodules [white arrows in . Some of which are measured in mm [yellow callipers in.


In ],. In ], and ,peri-hepatic, and . Peri-splenic ascites [arrowheads in.


Ultrasound-guided biopsy of an omental nodule, whose diagnosis was suspicious for carcinoma with the unknown primary site.


CT scan of the chest, including part of the superior abdomen, performed to complete staging after 2 weeks from the first CT scan, shows a dimensional and numerical reduction of peritoneal lesions [measures shown by yellow callipers in.


In ], as well as the resolution of perihepatic and peri-splenic ascites.


Peritoneal lymphoid aggregate with a central core of epithelioid cells (see box at higher magnification) without atypia or mitosis.


With only focal and weak positivity for cytokeratins AE1/AE3 A lot of immunohistochemical markers were performed (WT1, S100, Ber-EP4, oestrogen receptor, p63, ALK, BRAF, CD45, CD68 and CD79) and resulted negative.


Ziehl-Neelsen stain revealed the presence of acid-fast bacilli.


Intraoperative transesophageal echocardiogram images with color flow doppler of the main pulmonary artery (MPA), left pulmonary artery (LPA) and right pulmonary artery (RPA) prior to surgical pulmonary embolectomy. The images reveal significant flow acceleration across a dilated MPA (Panel A) and minimal to no antegrade flow into the LPA (panel B) and RPA (panel C). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article. ).


Intraoperative transesophageal echocardiogram images with color flow doppler showing the main pulmonary artery (MPA), left pulmonary artery (LPA) and right pulmonary artery (RPA) after surgical pulmonary embolectomy. The images reveal reduced flow acceleration across the MPA (Panel A) and significantly improved flow in the LPA (Panel B) and RPA (Panel C). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article. ).


Intraoperative transesophageal echocardiogram images showing a significantly dilated right ventricle (Panel A) that normalized (Panel B) after surgical embolectomy.


Optical coherence tomography (OCT) scan showing retinal pigment epithelium (RPE) repair process in the right eye during anti-VEGF treatment. 1 month after treatment: a subfoveal OCT scan shows splitting of the RPE (yellow arrow) with persistent well defined subretinal hyperreflective material (yellow star) and subretinal fluid; b OCT scan superior to the fovea shows continuity of the hyperreflective line attributable to the RPE (white arrow) and envelopment of the hyperreflective material (white star). 9 months after initiation of treatment; c Subfoveal OCT scan shows further consolidation of the hyperreflective material with persistent splitting of the RPE (yellow arrow); d OCT scan superior to the fovea shows reducing subretinal fluid and integrity of the RPE (white arrow).


Medical image.


Opisthotonus.


Abdominal muscle spasm. Trismus.


Neck stiffness. Recovery on Day 8.


Fungal blood culture demonstrating white to tan-colored, velvety and flat colonies with red soluble pigment.


Lactophenol cotton blue staining from fungal blood culture demonstrating septate hyphae and smooth conidia aloft phialides which are borne to metulae.


Contrast-enhanced computed tomography of the whole abdomen demonstrating small hypodense lesion with a thin enhancing rim at the spleen and extensive intra-abdominal lymphadenopathy.


MRI (T1 W axial, postcontrast) showing sequential evolution of right optic nerve tuberculoma.


Diffuse thickening with homogenous enhancement.


Ring enhancement with proptosis.


Necrotic lesion with thicker enhancing rim (after 8 weeks of treatment). Reduction in size and degree of enhancement (18 months).


The pathophysiologic process that produces the immune-related storm in thymoma has not yet been fully clarified. Some possible vicious cycles involve enhanced T-cell activity against antigens present in the thymus and in the "innocent" bystander organs, whereby growing amounts of preexisting autoreactive T-cells are unleashed from the medulla, breaking the immune-equilibrium existing in the normal thymus. In particular, the immature CD4+CD8+ double positive cells move to single positive CD4+ helper T-cells (binding MHC class II) and CD8+ cytotoxic T-cells (binding MHC cIass I) involved in the adaptive immunity while a negative selection leads to apoptosis of self-reacting T clones. In thymic neoplasia the immature thymic lymphocytes may escape quality control by DC prompting T-cell hyperactivation and autoimmune manifestations. DC, dentritic cell; APC, antigen presenting cell; MHC, major histocompatibility complex.


Hematoxylin-eosin (HE) immunostaining (IHC): fibrous septa within the tumor separate the lymphoepithelial elements (4x).


HE IHC: aggregates of large epithelial cells with a clear cytoplasm interspersed between lymphoid cells (20x).


CK 19 IHC: dense epithelial cell network (10x).


PD-L1 IHC (Clone 22 C3): Membranous positivity of the epithelial cells (20x).


TdT IHC: lymphocytes consist predominantly of immature T-cells.


CD8 IHC: immune-positivity of CD8 on immature lymphocytes (10x).


Longitudinal slices of computed tomography scans at baseline.


Post treatment. Showed a decrease of the mediastinum mass with intralesional hypondensity (red arrows) and pleural nodules (yellow arrows), defined as partial response according to iRECIST criteria.


Transthoracic echocardiography demonstrating tricuspid vegetation (arrow).


Transesophageal echocardiography five days after Fig. 1. No vegetation can be seen.


Computed tomography demonstrating mediastinal tumour.


Transhoracic echocardiography demonstrating enlarged tricuspid vegetation.


Axial fluid-attenuated inversion recovery image showing a bilateral hyperintense signal in the hypothalamus.


Timeline of Management and Interventions for M. abscessus subsp. massiliense Knee PJI at Both Institutions.


The dynamics of the throat swab and stool sample test of SARS-CoV-2 RNA, body temperature, blood cell counts, and medications of a mild COVID-19 during hospitalization. Antiviral medication: Kaletra, Arbidol, Darunavir, and Chloroquine. Supplementary medication: Thymalfasin and IVIG. IVIG, intravenous immunoglobulin; WBC, white blood cell count (3.5-9.5 x 109/. ; LYMPH, lymphocytes (1.1-3.2 x 109.


Serological assays of IgG and IgM specific to SARS-CoV-2 of a mild COVID-19 patient, with a severe COVID-19 case as the control. The presence and concentration of IgM and IgG targeting SARS-CoV-2 were measured using a fluorescent immunochromatography detection kit specific to the IgM and IgG against SARS-CoV-2. The cutoff values for IgG and IgM detection were 0.057 and 0.067, respectively.


Case 2: 3-year-old male child diagnosed as having spontaneous biliary peritonitis. (a) Follow-up T2-weighted magnetic resonance cholangio- Pancreatography image shows normally distended Gall Bladder.


Case 2: 3-year-old male child diagnosed as having spontaneous biliary peritonitis. , (b) Follow-up T2-weighted fat suppressed cholangio-pancreatography image of case 2 shows normal caliber common Bile duct.


Perfusion.


Blood pool. Images showed increased tracer uptake in both lungs.


Delayed images (C) also showed increased activity in the lungs and poor uptake in the skeleton.


Bulky condyloma acuminata in the genital area.


Timeline displaying the course of clinical symptoms of case 1.


Erosive esophagitis.


Erosive gastritis.


Sarcina ventriculi in esophageal biopsies. These microorganisms appear to be arranged in tetrads [ 200x.


Sarcina ventriculi in esophageal biopsies. But on higher magnification appear to be arranged in cubes composed of eight individual spheres [ 400x.


Circular gastric ulcer.


Timeline displaying the course of clinical symptoms of case 2.


Posterior dynamic images of Technetium-99m-ethylenedicysteine renogram for a 4-year-old boy, suspected for hypoplastic/ectopic right kidney.


Clinical course of the patient. Cytomegalovirus (CMV) copy numbers in folds of 105 in gray shown as drawn through line; administration of hyperimmune globulines (IVIG), cyclosporine (CsA), prednisolone, rituximab (depicted by crosses) and antiviral medication (ACV: acyclovir; FOS: foscarnet; GCV: ganciclovir; LMV: letermovir; VACV: valacyclovir) as indicated above, dectection of UL56 wild type (WT) is depicted as empty circle and UL56 C325Y as black circle respectively.


ECG upon admission shows sinus rhythm with mild ST-segment elevation in anterior and inferior leads.


Cardiac MRI PSIR- LGE views showing late gadolinium subepicardial enhancement in basal lateral segments in both. Four Chamber.


Short Axis views.


Troponin T level during hospitalization.


TTE images showing mitral valve prolapse with thickening of the mitral valve leaflets suspicious for infective endocarditis.


Severe mitral regurgitation seen on colour flow imaging.


TOE images showing a large mobile friable mass on the posterior mitral valve leaflet suspicious for infective endocarditis (A).


Mitral regurgitation could be seen on the colour flow image (B).


It shows changes consistent with severe colitis due to both graft versus host disease and cytomegalovirus infection.


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). Axials. T1 + Gadolinium.


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). T2-weighted.


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). Gradient echo sequence with a large poli-cystic enhancing selar lesion with extensive osteophytic reaction and invasion of the ipsilateral orbital apex associated with fibrous dysplasia and an enhancing selar mass lesion with their respectively Calcium intensities (white arrows).


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). CT-scans. Axial CT-scan showing the calcified pituitary gland (white arrow).


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). Coronal on bone density revealing thickness of the diploe on the right sphenoid wing (white arrow heads) and osteolytic lesion on the left orbital apex (black asterisk).


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). (F and G) axial and coronal 3D bone reconstruction showing calcified pituitary gland (red arrows) and a calcified rim around the tumor.


CT-scan. Axial slides (A - C) after tumor resection and post operative changes.


Platelet count plot from day 1 to day 60 depicting the drop and return to baseline X-axis: duration in days. Y-axis: platelet count x 105/mul.


Contrast enhanced axial abdominal CT demonstrating primary epiploic appendagitis adjacent to the sigmoid colon 7 months prior to presentation.


Longitudinal abdominal CT with contrast enhancement demonstrating primary epiploic appendagitis adjacent to the sigmoid colon 7 months prior to presentation.


Case 2. Spectral-domain optical coherence tomography (SD-OCT) scan after 3 anti-VEGF injections in the left eye. B SD-OCT scan of right eye. And left eye.


Case 2. Spectral-domain optical coherence tomography (SD-OCT) scan after 3 anti-VEGF injections in the left eye. Revealed photoreceptor dysfunction by showing disruption of the ellipsoid zone (white arrows) with thinning of the outer nuclear layer (white asterisks). B; SD-OCT scan of the left eye showed presence of well-defined hyperreflective material consistent with retinal scar.


Case 4. A, b Color fundus photograph (CFP) of AZOOR 10 years after photodynamic therapy in the right eye. A CFP of the right eye showed extensive macular scarring.


Case 4. B; CFP of the left eye showed peripapillary depigmentation and drusen like material.


Case 4. C; Fundus autofluorescence (FAF) in correspondence of these areas showed a mixed hypo-FAF and granular hyper-FAF signal with a leading hyper-FAF border at the junction between the involved and uninvolved retina (white arrow).


Case 4. D; After one year of follow-up FAF of the left eye revealed minimal progression of the peripapillary zonal lesion in the left eye (yellow arrow).


Abnormal discharge synchronized to the rhythmic jerk located in the right C4-P4. . Note: Red line indicates abnormal discharge synchronized to the rhythmic jerk located in the right C4.


Thyroid ultrasound. (A)
Case 1: transverse view of the right thyroid lobe with an ill-defined hypoechoic area (arrow).


Thyroid ultrasound. (B)
Case 1: longitudinal view of the right thyroid lobe with decreased blood flow within the hypoechoic areas on color-coded Doppler sonography.


Thyroid ultrasound. (C)
Case 2: transverse view of the right thyroid lobe with a distinct hypoechoic area (arrow).


Thyroid ultrasound. (D)
Case 2: transverse view of the right thyroid lobe with decreased blood flow within the hypoechoic area on color-coded Doppler sonography.


Evolution of UTC, salivary F and serum F during follow-up,
normalized by the upper limit normal range (ULNR).


MRI sequences during follow-up. (A) May/2007: coronal view on T 1-weighted MRI of
the pituitary gland identified a heterogeneous solid macroadenoma
(1.9x1.8 cm of diameter - arrow).


MRI sequences during follow-up. (B) August/2013: MRI after four years of
transsphenoidal surgery - questionable remnant tumor tissue or
arachnoid cyst (arrow).


Hyperintense areas in bilateral hippocampal white matter on T2-weighted coronal sections.


Diffuse slow waves superimposed with rapid delta "brush" activity.


Delta "brush" activity localized in the frontal regions in bilateral hemispheres.


Elevtroencephalogram with predominance of diffuse slow waves.


Fluid attenuation inversion recovery axial image at the level of upper medulla shows tiny hyperintense foci in the dorsal aspect of medulla at the caudal end of fourth ventricle - Area Postrema (arrows).


Mid sagittal T2-weighted image shows faint hyperintense linear streak in the dorsal aspect of upper medulla near the caudal end of fourth ventricle (arrow).


Diffusion weighted image shows no restriction.


No enhancement seen on post contrast scan.


Crops of small, red-yellow dome-shaped papules of approx. 6 mm with well-defined borders located on the anterior medial thigh.


Appearance of venous blood following phlebotomy, exhibiting a thick, milky supernatant.


Blood work on the day of admission and blood work on the last day of hospitalization.


A glomerulus showing cellular crescent. The underlying glomerular tuft shows segmental necrosis with fibrin exudation and presence of few karyorrhectic debris (periodic acid - Schiff stain, x400).


Course of the illness and successful response to tacrolimus.


Right eye, 6 days after initial presentation. Three days before this photograph, the eye was examined and no ulceration was found.


Left eye, 6 days after initial presentation. Initially an ulcer with minimal thinning, the marginal guttering has deepened considerably.


Diffusion-weighted image.


Diffusion restriction in bilateral dentate (arrow) nucleus in cerebellum showing corresponding low apparent diffusion coefficient (ADC) value on ADC images.


Hyperintensity noted on T2 fluid-attenuated inversion recovery images.


There are no signal changes seen on T2 weighted images (d).


Immunologcal findings. DIF shows. Immunoglobulin G (IgG).


Immunologcal findings. Complement 3 (C3) deposition along the cell surface of keratinocytes.


Immunologcal findings. (C) Results of immunoblotting of normal human epidermal extracts. Pemphigus vulgaris (PV) control serum reacted with the 160-kDa desmoglein (Dsg) 1 and the 130-kDa Dsg3 (lane 1), paraneoplastic pemphigus (PNP) control serum reacted with the 210-kDa envoplakin and the 190-kDa periplakin (lane 2), bullous pemphigoid (BP) control serum reacted with the 230-kDa BP230 and the 180-kDa BP180 (lane 3), anti-desmocollin (Dsc) monoclonal antibody (mAb) (lane 4) and the patient serum (lane 5) reacted strongly with the 110-kDa a-form and the 100-kDa b-form Dsc3. DIF: direct immunofluorescence.


Head computed tomography (CT) scan revealing a large left extra-axial cystic lesion that was being monitored before current symptomatology.


Head computed tomography (CT) scan showed the pre-existing cystic lesion in the left cerebellopontine angle with a slight right brainstem deviation, without associated edema (
2A), as confirmed by magnetic resonance imagining (MRI) (
2B).


Horizontal section of CT abdomen showing splenic infarct.


Coronal section of CT abdomen showing splenic infarct.


Patient 3. Axial contrast-enhanced orbital CT demonstrates marked swelling of the left medial rectus muscle with a more focal peripherally enhancing mass in the mid-muscle belly (white arrow). There is mild induration of the left retrobulbar fat with slight proptosis.


Two live dirofilarial worms.


Microscopic picture of the worm showing Cuticle and transverse striation.


(a,b) Sagittal and axial T2-weighted MR image shows a large cystic ovarian tumor of 5cm at maximum diameter. The tumor had arisen from the right ovary, the margin was smooth and the uterus was normal size.


(c) Ovarian endometrioid tumor of low malignant potential showing glands similar to the complex hyperplasia of the uterine endometrium.


(a) Brain magnetic resonance venography image obtained on admission showing occlusion of the left transverse and sigmoid sinuses.


(b) 3D TOF MRA showing high-grade left PCA stenosis.


(c) SPECT images obtained on day 2 from ictus showing left posterior ischemic lesion.


Magnetic resonance venography image obtained 28 days after admission showing recanalization of the venous sinus (d).


Improvement in vasoconstriction is observed on day 14 from ictus (e).


SPECT image obtained on day 28 from ictus showing absence of the ischemic lesion (f).


(a,c) Magnetic resonance angiography (MRA) confirmed the presence of a vasospasm involving the right anterior cerebral artery. On admission, MRA revealed vasoconstriction of the anterior cerebral artery. Vasoconstriction was normalized within 3 months.


(b,d) Magnetic resonance venography (MRV) confirmed the presence of a thrombosis involving the superior sagittal sinus. On admission, MRV revealed thrombosis of the superior sagittal sinus, which normalized within 3 months.


CT on admission and 25 months after chemotherapy. Enhanced CT on admission revealed ring enhancement around the periphery of the tumors and heterogeneous enhancement within the tumors (a).


CT on admission and 25 months after chemotherapy. CT also revealed multiple hepatic tumors with heterogeneous enhancement, and a swollen lymph node surrounding the lesser curve of the stomach (b, arrowhead).


CT on admission and 25 months after chemotherapy. Thickening of the stomach wall was indicative of a gastric tumor that was thought to have invaded the muscularis propria (c, arrowheads).


CT on admission and 25 months after chemotherapy. MRI on admission showed enhancement at the periphery of the tumors and heterogeneous enhancement within the tumors in the arterial phase.


CT on admission and 25 months after chemotherapy. , but there was no enhancement during the delayed phase.


CT on admission and 25 months after chemotherapy. CT finding 25 months after chemotherapy showed a remarkable reduction in the size of the metastatic liver tumors without enhancement (f).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD before chemotherapy revealed a Bormann type 3 advanced tumor about 30 mm in diameter in the lower part of the stomach (a).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. Closer view of the gastric tumor (b).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD performed 8 months after chemotherapy showed a remarkable reduction in the size of the tumor, which had the appearance of an excavated lesion with marginal protrusion (c).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD performed 25 months after chemotherapy revealed an even greater reduction in the size of the tumor, which had the appearance of an extremely small elevated lesion with a scar (d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. HE staining revealed that the tumor was a poorly differentiated adenocarcinoma (a). Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. Immunohistochemical evaluation of a tumor biopsy specimen revealed that the tumor cells were positive for AFP Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. , PIVKA-II Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen.HER2 Original magnification x400 (a-d).


Platelet Trends with platelet values reported in thousands/uL for patient with suspected ITP. Day 1 - day 5 were hospitalization days, while days 8 - 46 were collected at outpatient follow-up appointments. Prednisone treatment was initiated on day 1. Day 5 corresponds to the first laboratory value after treatment with intravenous immunoglobulin.


Diffuse petechial rash on the patient's lower extremities (the right lower leg) - day two of hospitalization.


Sheep blood agar plate showing 1-2 mm sized, raised, grayish-white colonies after 48 hr incubation at 37CC, 5%-CO2.


Gram-stained smear of colony on BAP after 48 hr incubation at 37CC showing gram negative coccobacili.


Computed tomography (CT) manifestation of recurrent pulmonary infection. The recurrent pneumonia was observed during the hospitalization.


Computed tomography (CT) manifestation of recurrent pulmonary infection.could be relieved by multiple antibiotic treatments.


Computed tomography (CT) manifestation of recurrent pulmonary infection.


Computed tomography (CT) manifestation of recurrent pulmonary infection. Showed exacerbation of infection before the detection of mycobacterium kansasii (with air bronchogram and pulmonary consolidation), and the situation did not get improved after multiple treatments.


Dark red, necrotic, slightly tender lesions developed symmetrically on MCP joints and knees.


Hematoxylin and eosin (HE) staining shows blood vessels (white areas) with surrounding neutrophilic inflammatory aggregates (arrows), establishing the diagnosis of neutrophilic vasculitis. Picture magnification: 20x; scale bar: 50 mu.


A-C-D show a lateral view of the patient affected by lipodystrophy with particular accumulation of adipose tissue in the region of the neck and trunk. Fig. 2B shows a posterior view.


Chest x-ray shows the ovalization of the tracheal lumen (arrow).


Magnetic resonance imaging of brain showing isointense sellar lesion with enhancement of pituitary stalk.


Magnetic resonance imaging of brain showing uniform enhancement of sellar lesion in contrary to ring enhancement seen in tuberculoma.


Incision of the right corpus cavernosum contributed to drainage of a large amount of pus.


Extra-oral photograph shows protruding mandible and hypotelorism.


Intra-oral photograph shows malformed dentition with pulpal exposure of all teeth in the maxillary arch.


Intra-oral photograph shows partial ankyloglossia (arrow).


Orthopantomograph shows multiple unerupted teeth and missing permanent tooth germs (black arrow), short roots (white arrow), and enlarged pulpal chambers (dashed arrow).


Extra-oral photograph shows dolicocephalic, hypoplastic maxilla (white arrow), with anti-mongoloid features (black arrow).


Medical image.


Intra oral photograph of the maxillary arch shows multiple missing teeth. Intra oral photograph shows ankyloglossia (arrow), widely spaced, discolored, and malformed teeth.


Orthopantomograph shows multiple impacted teeth, multiple missing permanent tooth germs, retained teeth (arrow), short roots (arrow), and enlarged pulp chambers (arrow).


Hand-wrist radiograph shows incomplete capping of the epiphysis of the mid phalanx (small arrow) and incomplete fusion of the epiphysis and diaphysis of the radius (large arrow).


Significantly decreased FDG uptake on PET/CT was seen 3 months after intensive treatment.


Chest radiograph and chest HRCT scan on admission. (A) showed patchy shadows in the right lung (arrows) and the lower left lung (arrow).


Chest radiograph and chest HRCT scan on admission. (B and C) Multiple masses and small nodules over both lungs (arrows). . Abbreviation: HRCT, high-resolution computed tomography.


Chest HRCT scan after 12 months of antibiotic therapy. (A and B) Most of the lung lesions are absorbed, but there were still some strip shadows in both lungs (arrows). . Abbreviation: HRCT, high-resolution computed tomography.


Cerebrospinal fluid (CSF) studies: CSF opening pressure, glucose, and WBC count over the course of initial hospitalization with initiation of steroids on day 13 (red arrow).


Corneal perforation and iris protrusion in the right eye.


Corneal perforation and iris protrusion in the left eye.


Eccentric penetrating keratoplasty of the right eye.


Corneal patch grafts and amniotic membrane transplant of the left eye.


Large diameter penetrating keratoplasty of the left eye.


Mature cataract OS prior to surgery (Case 1).


Pseudophakia OS 8 weeks after surgery. Concentric rings from the optical portion of the IOL can be noted in this image (Case 1).


Variation of total billirubin and hematocrit of both the twins (arrow represents the transfusion received by them).


Anti-M alloantibody titre variation in mother and twins.


With right calf fasciotomy.


Surgical debridement of the right foot ulcer.


Right leg Ischemic and evidence of Gangrene.


Destroyed tricuspid valve with vegetations and necrotic tissues.


PFM coil removed.


Tissue valve implanted in the tricuspid position.


Mucosal ulcers. Oral mucosal aphthous ulcers.


Mucosal ulcers. Penile ulcer.


Light microscopy imaging of the renal biopsy demonstrating a small vessel vasculitis. Original magnification x400, using Haematoxylin-eosin stain.


Light microscopy imaging of the renal biopsy demonstrating a medium sized vasculitis. Original magnification x100, using Haematoxylin-eosin stain.


Magnetic resonance image showing a high signal intensity and enhancement in head of proximal radius. Synovial hypertrophy and fluid collection in elbow joint.


(A) Multiple translucent skin-colored, bluish cystic lesions in periorbital distribution, cheeks, and zygomatic region.


(B) Unilocular cyst lined by two layers of flattened cuboidal epithelium without any evidence of decapitation in lining cells (hematoxylin and eosin, x40 magnification).


(C) Whitish clod (yellow arrow) without crater seen on dermoscopy (nonpolarized mode, x170 magnification).


(D) Yellowish globules (blue arrow) with multiple telangiectasias (white arrow) seen on dermoscopy (polarized mode, x170 magnification).


Hematoxylin and eosin stain of a duodenal biopsy specimen showing inflammatory cell infiltrate, marked blunting of villi and Strongyloides stercoralis larvae (x100).


Longitudinal and cross-sectional view of a duodenal biopsy specimen stained with hematoxylin and eosin showing several S. stercoralis larvae lying within a crypt (x40).


Transesophageal echocardiogram showing vegetation/mass noted on septal leaflet of the Tricuspid Valve. RA: Right atrium, LA: Left atrium, RV: Right ventricle.


Transthoracic echocardiogram image showing side by side 2-dimensional and color doppler imaging of membranous septum without VSD. RA: Right atrium, LA: Left atrium RV: Right ventricle, AoV: Aortic Valve.


Transesophageal echocardiogram image showing side by side 2-dimensional and color doppler imaging of IE created defect. LV to RV to Anterior septal commissure of tricuspid valve to RA. RA: Right atrium, LA: Left atrium, RV: Right ventricle, LV: Left ventricle, VSD: Ventricular septal defect.


Intraoperative image from the surgeon's viewpoint looking at the tricuspid valve from the right atrial position. The septal leaflet is being held by forceps, and a vegetation is notable in the abscess cavity where the ventricular septal defect begins.


Intraoperative image from the surgeon's viewpoint. Splayed ascending aorta looking at the aortic valve showing erosion of the noncoronary cusp of the aortic valve.


Chest computed tomography scan. Bronchiectasis and multiple granular shadows are randomly distributed in the bilateral lobes, and consolidation in the lower left lobe is present.


Flow cytometric analysis of phosphorylationed STAT1 (pSTAT1) in monocytes after the stimulation with interferon-gamma (500 U/mL). The analysis gate was set in CD14+ cells. Blue areas indicate healthy adults (n = 3), whereas pink areas indicate the patient. Gray and purple areas indicate pSTAT1 in monocytes without interferon-gamma stimulation in healthy adults and the patient, respectively.


Preoperative findings. A; Anterior segment photography obtained before the procedure reveals a freely movable conjunctival cyst (black arrow); b Anterior segment optical coherence tomography (AS-OCT) reveals a subconjunctival cyst filled with homogenous fluid (white arrow).


A; Family 1, case 1: erythematous, papular lesions of the palms mimicking erythema multiforme or secondary syphilis.


B; Family 1, case 1: papular enanthem of the oral cavity.


C; Family 1, the child: onychomadesis of a fingernail 2 months after Coxsackievirus A6 infection.


D; Family 2, case 3: erythematous, papulovesicular lesions of the right foot.


Gram-stain of bronchoalveolar lavage. Black arrows indicate capsulated Gram-negative large rod.


Multiplex PCR. The isolated strain possessed iutA, rmpA, entB, and mrkD.


Pilonidal abscess, sagittal computed tomography (CT) images on admission (A) CT scan showing soft-tissue ill-defined thickening from the lumbar spine to the sacrum, with a focal well-defined fluid collection measuring approximately 2.9 x 0.8 cm (arrow).


Time of neutrophil recovery (B) Three weeks postinduction CT sagittal images showing increase in well-defined fluid collection, now measuring 1.3 x 2.2 x 6.4 cm (marked with arrow).