Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


X-ray pelvis showing reduced joint space with destruction of ischial tuberosity, acetabulum, and femoral head (arrowhead).


Hematoxylin and eosin staining (x10 objective): intense inflammatory response and giant cell reaction against lamellated membranes (arrowhead).


Hematoxylin and eosin staining (x40 objectives): Giant cell reaction against lamellated membranes (arrowhead).


Magnetic resonance imaging of the patient's brain. . Notes: (A) A T2-weighted image showing hyperintensity lesions (arrows) in the temporal lobes and left occipital lobe.


Magnetic resonance imaging of the patient's brain. (B) Multiple hyperintensities (arrows) in the temporal and parietal lobes and demyelination in the white matter surrounding the lateral ventricles revealed by the fluid-attenuated inversion recovery sequences.


Magnetic resonance imaging of the patient's brain. (C) A susceptibility-weighted image showing a low signal (arrow) in the right frontal lobe.


The electroencephalogram of the patient showing slow-waves characterized by strong peaks of delta (delta) and theta (theta) frequencies in the right frontal lobe. . Note: The arrows point to slow-waves from the Fp2-C4 and Fp2-L4.


Multiplex PCR. The present strain harbored iutA, rmpA, entB, and mrkD genes.


The patient developed ptosis, opthalmoplegia, chemosis, pupillary dilatation, and loss of sensation over the left eyelid in the immediate postoperative period.


Three months after the surgery, there was partial recovery of ptosis and opthalmoplegia.


Abduction of the left eye has not recovered in three months.


Three months after the surgery, chemosis is still present while opthalmoplegia has partially recovered.


Brain computed tomography scan of case 2. (A) The CT images show blocking of the right lateral ventricle but with obvious enlargement of the left lateral ventricle and the fourth ventricle, which indicate separation of the ventricular system.


Brain computed tomography scan of case 2. (B) Red arrow show the drainage tube.


RE. Macula with cotton wool spots, and ,minor microangiopathy signs temporal from the fovea.


FFA temporal periphery highlighting an area of ischemia bordered by neovascularisation.


FFA superior with microangiopathy.


Plain CT.


Contrast-enhanced scan. Of the kidney. The arrow shows a mass of 5.5 x 5.0 x 4.0 cm on the left side.


A pathological study of the mass on the left kidney confirmed it as renal cell carcinoma, clear cell type. (A) Low magnification.


A pathological study of the mass on the left kidney confirmed it as renal cell carcinoma, clear cell type. (B) High magnification. The cells have a clear cytoplasm, surrounded by a distinct cell membrane, and contain round and uniform nuclei.


Image of subconjunctival hemorrhage.


Toraks ct of first hospitalization day.


Toraks ct of third hospitalization day.


2D echo PLAX view showing subaortic membrane with marked left ventricular hypertrophy, and ,mild pericardial effusion.


2D echo PLAX view showing vegetation on anterior mitral leaflet, measuring 10 x 6 mm.


MRI brain axial section showing hypointense signal intensity alteration on T1WI.


Hyperintense on T2 FLAIR. In left parietal region, suggestive of acute infarct. There is also perilesional edema.


Changes of rectal ulcer on colonoscopy before.


After. Antiviral treatment.


The Genotype Mycobacterium CM (HAIN Lifescience) hybridization pattern for isolates from blood and pus samples (strip 3 and 4 from the top) with template (strip 1) for evaluation. Band 1 (CC): conjugate control; band 2 (UC): universal control; band 3 (GC): genus control; bands 5, 6, and 10: probes specific for M. abscessus.


FA of the patient's right eye taken over a 2-year period. . Notes: (A and B) Initial visit (early phase of FA of the right eye reveals a small irregular hyperfluorescence area inferonasal to the fovea with late-phase leakage that corresponds to the juxtamacular CNV lesion; arrows).


FA of the patient's right eye taken over a 2-year period. (C and D) One week after cessation of steroid therapy (a fulminant recurrence and development of CNV membrane with involvement of the fovea; arrows).


FA of the patient's right eye taken over a 2-year period. (E and F) Three months after PDT (progressive enlargement of CNV membrane).


FA of the patient's right eye taken over a 2-year period. (G) Recurrent activity of CNV membrane 8 months after the second intravitreal ranibizumab injection (circle).


FA of the patient's right eye taken over a 2-year period. (H) Two months after periocular triamcinolone injection combined with intravitreal ranibizumab injection (almost complete regression of active CNV membrane). . Abbreviations: CNV, choroidal neovascular membrane; FA, fluorescein angiography; PDT, photodynamic therapy.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (a) Lesions growing on the elderly patient's scalp resembled pustular erosions with eschars.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (b) Assuming an infectious origin, some lesions were detached successfully (indicated by an arrow) by using a gauze soaked with a 1 % NCT solution. Tissue and swabs were collected and sent for microbial culture.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (c) On day 3, treatment with 1 % NCT showed visible but slow regression of the lesions. Combination therapy with 1 % NCT and 1 % NBrT was commenced.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (d) The next day (day 4), the 1 % NCT and 1 % NBrT combination treatment had accelerated the regression and softening of the lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (e) By the fifth day of treatment, lesions together with a subcutaneous portion of skin could be partly removed without serious bleeding. Application of 0.1 % BAT twice daily was commenced at home.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (f) Evident accelerated tissue repair and almost total clearance of remaining lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (g) Wounds were epithelialized, with no evident recurrence of lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (h) Further epithelialization of the wounds from the previous lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (i) Remarkable epithelialization and tissue repair induced the decision to end the treatments at the clinic.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (j) The skin was completely epithelialized and returned to normal pigmentation. Application of 0.1 % BAT was stopped.


CT Scan without contrast of the left lower extremity indicating the mass (red arrow).


MRI without contrast of the hip showing the fluid collection around left hip joint (red arrow).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. , Timeline showing absolute CD4 and CD8 T cell counts, including effector-memory subsets and NK cell counts (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. Absolute B cell counts (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. , Anti-SARS-CoV-2 S protein IgG, IgA and IgM antibody levels as assessed by an in-house developed Luminex assay for each plasma The cytopathic effect on VeroE6 cells was evaluated after inoculation with SARS-CoV-2 from nasopharyngeal swabs: C+, successful virus isolation; C-, absence of virus isolation. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. As well as in the patient's serum before and following plasma transfusions (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. (E), Activity of neutralizing antibodies was assessed by a SARS-CoV-2 pseudovirus neutralization assay for each plasma and in patient's serum at different time-points. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Anti-SARS-CoV-2 antibody and SARS-CoV-2 mRNA follow-up before and after plasma transfusions. (F), Over-time follow-up of SARS-CoV-2 RNA detection in nasopharyngeal swabs. (A-F), The arrows indicate the 4 cycles of plasma transfusion (two units given on two consecutive days of each cycle).


Computed Tomography of chest, abdomen, and pelvis of patients 1, 2, and 4. (A) Patient 1: splenic nodule indicated by arrow.


Computed Tomography of chest, abdomen, and pelvis of patients 1, 2, and 4. (B) Patient 1: right sided pulmonary lesion indicated by arrow.


Computed Tomography of chest, abdomen, and pelvis of patients 1, 2, and 4. (C) Patient 2: hepatosplenomegaly.


Computed Tomography of chest, abdomen, and pelvis of patients 1, 2, and 4. (D) Patient 4: right upper lobe pulmonary lesion.


Chest X-Ray of a 3-months-old boy with Pre-XDR TB. It shows infiltrate at the upper-middle right lung field with an increased of bronchovascular marking.


Chest X-Ray of a 14-years-olf girl with Pre-XDR TB. It shows opacity at the right hilar, lobulated infiltrate in the left apex, nodular at left hilar, and lymph node enlargement at bilateral peri-hilar.


A: Bowel perforation at the cecum.


B: Bowel perforation at the terminal ileum.


C: Laparotomy wound at the postoperative period.


Facials features of the patient. Our patient expressed the typical facial phenotype comprising epicanthus, midface hypoplasia, flat nasal bridge, small triangular nose with anteverted nostrils, carp-shaped mouth with full lips, and dental diastema at age 6 months.


Facials features of the patient. And 3 yr.


Photomicrograph of the peripheral blood of our case with ATR-X syndrome. It shows cells containing HbH inclusions in our patient.


Photomicrograph of the peripheral blood of our case with ATR-X syndrome.also his mother.


Photomicrograph of the peripheral blood of our case with ATR-X syndrome. And eldest sister.


Patch test results (after 48 h):. Positive reaction to para-aminosalicylic acid.


Positive reaction to prothionamide.


Computed tomography scan image: the subdural collection is increased in dimension with a higher density in the posterior part by persistent midline brain shift.


Postsurgical computed tomography scan control shows the evacuation of the collection with air in the anterior part and a reduction of midline brain shift.


Ultra-wide field color fundus photograph of the right and left eye depicting diffuse midperipheral chorioretinal atrophy with sparing of the central macula. . Note: The left eye also has central submacular fibrosis.


Fluorescein angiogram (FA) transiting the left eye reveals diffuse atrophy of the choriocapillaris sparing the central macula. . Notes: A central hyperfluorescent lesion in the early images stains (00:29) in the late angiographic images centrally (04:28) (arrowhead). Mild leakage is apparent nasally (arrow).


Saline wet mount showing bile stained, thick walled egg with hexacanth embryo and without polar filaments.


Percutaneous pigtail drain at the right lower abdomen.


Cystoscopic view of a small perforation at the posterior wall of bladder.


Retrograde cystography showing no contrast extravasation. Filling phase.


Retrograde cystography showing no contrast extravasation.


Retrograde cystography showing no contrast extravasation. Voiding. Post voiding film.


Macroglossia and elfin features.


Marked acanthosis nigricans and hirsutism, distended abdomen.


Rough skin (upper extermities).


Rough skin (lower extremities).


Crowding of teeth, hyperplastic gingiva.


Postoperative picture, extraction of the offending teeth.


Bone Marrow aspirate smears, Wright-Giemsa Stain 1000X.


FISH characterization of double heterologous Robertsonian translocations. Bone marrow metaphase hybridized with fluorescent DNA probes for 15q22 (PML green), 15q11.2 (SNRPN orange), Cen15 (alpha satellite aqua), chromosome 14q32 (5'IGH green, 3'IGH orange) and chromosome 13q14(RB-1 green). Note the absence of a normal chromosome 14.


Timeline of the patient's clinical course after cardiac surgery.


Vertebral magnetic resonance imaging of the vertebral lesions. Vertebral magnetic resonance imaging revealed lesions of the vertebral bodies at T8-T9-L4-L5-S1 and invertebral disks between T8-T9.


Vertebral magnetic resonance imaging of the vertebral lesions. L4-L5-S1 , with an epidural abscess of 5 cm at the L3 and L4 levels, consistent with a pyogenic vertebral osteomyelitis.


99mTc-methylene diphosphonate bone scintigraphy showing diffusely increased left rib cage uptake (anterior a, posterior b; arrows). Transaxial single photon emission computed tomography (SPECT) and SPECT/CT images (c, e; arrows) show diffusely increased radiotracer uptake involving the left-sided ribs.


99mTc-methylene diphosphonate bone scintigraphy showing diffusely increased left rib cage uptake (anterior a, posterior b; arrows). Transaxial CT (bone window, d) shows normal left-sided ribs with regular cortical outlines.


99mTc-methylene diphosphonate bone scintigraphy showing diffusely increased left rib cage uptake (anterior a, posterior b; arrows). Transaxial CT (soft tissue window,. Shows a pleural-based soft tissue density lesion in the left lung lower lobe. Arrow head) with diffuse circumferential pleural thickening. Arrow).


Plain pelvic X-ray showing prostatic urethral calculus.


Micturating cystourethrogram (MCUG) showing huge prostatic cavity.


Petechial rash found in the distal third of the legs and the feet.


Petechial rash on buccal mucosa.


Demonstrating nail ridging.


EKG showing ST segment elevations in leads II, III, and aVF.


Course of CA 19-9 level. PD = Progressive disease; nab-paclitaxel = nanoparticle albumin-bound paclitaxel.


Midline rudimentary uterus (black arrow) with fallopian tube on both sides. Both gonad at the two ends, vas can be identified (indicated by forceps tip) along the vascular pedicle. Line diagram (inset) showing the anatomical details of the case. (u = uterus, v = vagina, F. T. = fallopian tube, T = testis, dotted line showing vas deferens).


Excised uterus (blue arrow) along with the bilateral fallopian tube. Both testis separated (black arrows) from the Mullerian remnants.


Distal most part of the rudimentary vagina, the vaginal cavity opened (black arrow) to remove the mucosa.


Photomicrographs. X100,. Papanicolaou Stain) show epithelioid cells. Arrow).


With pale elongated oval shaped cells. X200,. Papanicolaou Stain) showing slipper or sole of the foot shaped nuclei. Inset).


Computed tomography (CT), chest. Disseminated atypical pulmonary infiltrates (day +145 after alloHSCT).


Computed tomography (CT), chest. Chest CT following antimycotic therapy (day +170).


Computed tomography (CT), chest. Disease progression after three courses of rituximab, and ,two courses R-CHOP (day +228).


Computed tomography (CT), chest. Complete remission (CR) after five courses of brentuximab vedotin and three courses of third-party EBV-specific T-cells.


Histopathology and immunohistochemistry of pulmonary tumor biopsies. AlphaCD20.


Histopathology and immunohistochemistry of pulmonary tumor biopsies. MiB1.


Histopathology and immunohistochemistry of pulmonary tumor biopsies. AlphaLMP1.


Histopathology and immunohistochemistry of pulmonary tumor biopsies. AlphaCD30.


Nocardial brain abscess. On the 18th day after admission, diffusion weighed axial MRI of our patient detected brain abscesses. The lesion had mixed signal intensity with hypointense capsule surrounded by high signal edema zone.


Comparison of cross-sectional chest CT images obtained from the patient at different time points. A1-4 October 5th, 2020: The day of admission; B1-4 Eighth day after admission on October 13th, 2020; C1-4 October 22nd, 2020 The day of discharge; D1-4 November 14th, 2020 20 days after discharge; E1-4 February 6th, 2021 Nearly 4 months after discharge.


A flow chart describing the patient diagnosis process.


Clinical photograph of the left eye following corneal tear repair with fibrin glue. Note the central large wound.


A: CT scan image after the initial surgery showing a round, 1.9 mm x 2.1 mm sized radio dense (400 Hounsfield Units) lesion close to the retina in the left globe.


B: CT scan following aspiration of the PFCL bubble showing the absence of any radio dense lesions.


A single axial image from a Thoracic Computed Tomography (CT) scan acquired on Day 110 in a leukaemic patient with Invasive Pulmonary Aspergillosis (IPA). A 4 mm endobronchial valve (Zephyr , Pulmonx Inc. Neuchatel, Switzerland) is demonstrated within the lingular segmental bronchus proximal to an alveolar-pleural fistula caused by rupture of a fungal mass lesion. There has been a significant improvement in the previously demonstrated left-sided pneumothorax.


Images of CT scan of chest obtained from 2 year old child with empyema. A) Large pleural effusion with resulting left lower lobe compressive atelectasis.


Images of CT scan of chest obtained from 2 year old child with empyema. B) Left upper lobe consolidation with air bronchogram.


Clinical phenotype in a patient with NF-kappaB1 deficiency. (A) Skin biopsy showing a dense cellular infiltrate by Langerhans cells. Magnification 200x.


Clinical phenotype in a patient with NF-kappaB1 deficiency. Hematoxilin-eosin; (B) Skin biopsy with Langerhans cells infiltrating epidermis and subcutaneous tissues, positive to CD1a. Magnification 200x.


Clinical phenotype in a patient with NF-kappaB1 deficiency. Immunohistochemistry CD1a; (C) Panoramic view of bone marrow with many histiocytes with granular cytoplasm. Magnification 40x. Inside images: high power view of histiocytes between hematopoietic cells. They were intensely positive with acid-alcohol techniques (Ziehl Nielsen). Magnification 400x.


Clinical phenotype in a patient with NF-kappaB1 deficiency. Hematoxilin-eosin and Ziehl Nielsen; (D) Panoramic view of duodenal biopsy with villi shortened and lamina propria expanded by many granular histiocytes that stained positive with Ziehl Nielsen to detect Acid-resistant bacilli (inside). Magnification 200x. Hematoxilin-eosin. Inside Ziehl-Nielsen.


Clinical phenotype in a patient with NF-kappaB1 deficiency. Magnification 200x (E) Post-contrast coronal T2-weighted MRI of the abdomen showing mesentery enhancement.


Clinical phenotype in a patient with NF-kappaB1 deficiency. (F) Small bowel biopsy showing myenteric plexus with lymphoplasmocitoid inflammatory cells. Magnification 200x.


The glomerulus reveals features of collapsing glomerulopathy, with epithelial cell proliferation and collapse of underlying capillary walls. Tubules reveal flattening of the epithelium, distension of lumens, and focal intraluminal accumulation of cellular debris (periodic acid-Schiff stain, x 200).


Kinetics of PB19 viremia from detection to 6 weeks after transplantation.


A magnified view of viral loads of PB19 (notice the Y axis difference) from the initiation of the second course of intravenous immunoglobulin IVIg = intravenous immunoglobulin 500 mg/kg (gray dot); CDV = cidofovir 0.5 mg/kg (blue dot); dotted line = day of transplantation.


A computed tomography scan of the brain that shows the patient's initial acute subdural hematoma before surgery.


After evacuation.


A computed tomography scan of the brain that shows the patient's recurrent acute subdural hematoma.


After the second evacuation.


Chest CT scan of COVID-19 pneumonia (first chest CT scan). Axial sections of the chest CT scan at different levels show bilateral ground-glass opacities and consolidation images that are bilateral, subpleural, and located mainly in posterior regions (A-C).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). The chest CT scan performed 4 weeks after the management of severe COVID-19 pneumonia reveals the appearance of bronchiectasis. Green arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). The chest CT scan performed 4 weeks after the management of severe COVID-19 pneumonia reveals the appearance of bronchiectasis. Green arrow),. Fissure deformity. Orange arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Paracicatricial emphysema. Red arrow), and . Cavitation in the right middle lobe. Black arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Paracicatricial emphysema. Red arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Subpleural reticulations. Blue arrow),. Lobular distortions. Violet arrow).


Post-corticotherapy chest CT scan (third chest CT scan). The chest CT scan performed after 3 months of corticotherapy of post-COVID-19 symptoms reveals the regression of ground-glass lesions and bronchiectasis, and the persistence of paracicatricial emphysema (A-C).


Post-corticotherapy chest CT scan (third chest CT scan). The chest CT scan performed after 3 months of corticotherapy of post-COVID-19 symptoms reveals the regression of ground-glass lesions and bronchiectasis, and the persistence of paracicatricial emphysema (A-C). (B-D) Show the disappearance of the cavity image of the right middle lobe, the regression of retraction signs, and the persistence of few reticulation lesions.


Post-corticotherapy chest CT scan (third chest CT scan). (B-D) Show the disappearance of the cavity image of the right middle lobe, the regression of retraction signs, and the persistence of few reticulation lesions.


Chest X-ray showing multiple cysts.


Axial contrast-enhanced CT images show multiple omental nodules [white arrows in . Some of which are measured in mm [yellow callipers in.


In ],. In ], and ,peri-hepatic, and . Peri-splenic ascites [arrowheads in.


Ultrasound-guided biopsy of an omental nodule, whose diagnosis was suspicious for carcinoma with the unknown primary site.


CT scan of the chest, including part of the superior abdomen, performed to complete staging after 2 weeks from the first CT scan, shows a dimensional and numerical reduction of peritoneal lesions [measures shown by yellow callipers in.


In ], as well as the resolution of perihepatic and peri-splenic ascites.


Peritoneal lymphoid aggregate with a central core of epithelioid cells (see box at higher magnification) without atypia or mitosis.


With only focal and weak positivity for cytokeratins AE1/AE3 A lot of immunohistochemical markers were performed (WT1, S100, Ber-EP4, oestrogen receptor, p63, ALK, BRAF, CD45, CD68 and CD79) and resulted negative.


Ziehl-Neelsen stain revealed the presence of acid-fast bacilli.


Intraoperative transesophageal echocardiogram images with color flow doppler of the main pulmonary artery (MPA), left pulmonary artery (LPA) and right pulmonary artery (RPA) prior to surgical pulmonary embolectomy. The images reveal significant flow acceleration across a dilated MPA (Panel A) and minimal to no antegrade flow into the LPA (panel B) and RPA (panel C). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article. ).


Intraoperative transesophageal echocardiogram images with color flow doppler showing the main pulmonary artery (MPA), left pulmonary artery (LPA) and right pulmonary artery (RPA) after surgical pulmonary embolectomy. The images reveal reduced flow acceleration across the MPA (Panel A) and significantly improved flow in the LPA (Panel B) and RPA (Panel C). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article. ).


Intraoperative transesophageal echocardiogram images showing a significantly dilated right ventricle (Panel A) that normalized (Panel B) after surgical embolectomy.


Optical coherence tomography (OCT) scan showing retinal pigment epithelium (RPE) repair process in the right eye during anti-VEGF treatment. 1 month after treatment: a subfoveal OCT scan shows splitting of the RPE (yellow arrow) with persistent well defined subretinal hyperreflective material (yellow star) and subretinal fluid; b OCT scan superior to the fovea shows continuity of the hyperreflective line attributable to the RPE (white arrow) and envelopment of the hyperreflective material (white star). 9 months after initiation of treatment; c Subfoveal OCT scan shows further consolidation of the hyperreflective material with persistent splitting of the RPE (yellow arrow); d OCT scan superior to the fovea shows reducing subretinal fluid and integrity of the RPE (white arrow).


Medical image.


Opisthotonus.


Abdominal muscle spasm. Trismus.


Neck stiffness. Recovery on Day 8.


Fungal blood culture demonstrating white to tan-colored, velvety and flat colonies with red soluble pigment.


Lactophenol cotton blue staining from fungal blood culture demonstrating septate hyphae and smooth conidia aloft phialides which are borne to metulae.


Contrast-enhanced computed tomography of the whole abdomen demonstrating small hypodense lesion with a thin enhancing rim at the spleen and extensive intra-abdominal lymphadenopathy.


MRI (T1 W axial, postcontrast) showing sequential evolution of right optic nerve tuberculoma.


Diffuse thickening with homogenous enhancement.


Ring enhancement with proptosis.


Necrotic lesion with thicker enhancing rim (after 8 weeks of treatment). Reduction in size and degree of enhancement (18 months).


The pathophysiologic process that produces the immune-related storm in thymoma has not yet been fully clarified. Some possible vicious cycles involve enhanced T-cell activity against antigens present in the thymus and in the "innocent" bystander organs, whereby growing amounts of preexisting autoreactive T-cells are unleashed from the medulla, breaking the immune-equilibrium existing in the normal thymus. In particular, the immature CD4+CD8+ double positive cells move to single positive CD4+ helper T-cells (binding MHC class II) and CD8+ cytotoxic T-cells (binding MHC cIass I) involved in the adaptive immunity while a negative selection leads to apoptosis of self-reacting T clones. In thymic neoplasia the immature thymic lymphocytes may escape quality control by DC prompting T-cell hyperactivation and autoimmune manifestations. DC, dentritic cell; APC, antigen presenting cell; MHC, major histocompatibility complex.


Hematoxylin-eosin (HE) immunostaining (IHC): fibrous septa within the tumor separate the lymphoepithelial elements (4x).


HE IHC: aggregates of large epithelial cells with a clear cytoplasm interspersed between lymphoid cells (20x).


CK 19 IHC: dense epithelial cell network (10x).


PD-L1 IHC (Clone 22 C3): Membranous positivity of the epithelial cells (20x).


TdT IHC: lymphocytes consist predominantly of immature T-cells.


CD8 IHC: immune-positivity of CD8 on immature lymphocytes (10x).


Longitudinal slices of computed tomography scans at baseline.


Post treatment. Showed a decrease of the mediastinum mass with intralesional hypondensity (red arrows) and pleural nodules (yellow arrows), defined as partial response according to iRECIST criteria.


Transthoracic echocardiography demonstrating tricuspid vegetation (arrow).


Transesophageal echocardiography five days after Fig. 1. No vegetation can be seen.


Computed tomography demonstrating mediastinal tumour.


Transhoracic echocardiography demonstrating enlarged tricuspid vegetation.


Axial fluid-attenuated inversion recovery image showing a bilateral hyperintense signal in the hypothalamus.


Timeline of Management and Interventions for M. abscessus subsp. massiliense Knee PJI at Both Institutions.


The dynamics of the throat swab and stool sample test of SARS-CoV-2 RNA, body temperature, blood cell counts, and medications of a mild COVID-19 during hospitalization. Antiviral medication: Kaletra, Arbidol, Darunavir, and Chloroquine. Supplementary medication: Thymalfasin and IVIG. IVIG, intravenous immunoglobulin; WBC, white blood cell count (3.5-9.5 x 109/. ; LYMPH, lymphocytes (1.1-3.2 x 109.


Serological assays of IgG and IgM specific to SARS-CoV-2 of a mild COVID-19 patient, with a severe COVID-19 case as the control. The presence and concentration of IgM and IgG targeting SARS-CoV-2 were measured using a fluorescent immunochromatography detection kit specific to the IgM and IgG against SARS-CoV-2. The cutoff values for IgG and IgM detection were 0.057 and 0.067, respectively.


Case 2: 3-year-old male child diagnosed as having spontaneous biliary peritonitis. (a) Follow-up T2-weighted magnetic resonance cholangio- Pancreatography image shows normally distended Gall Bladder.


Case 2: 3-year-old male child diagnosed as having spontaneous biliary peritonitis. , (b) Follow-up T2-weighted fat suppressed cholangio-pancreatography image of case 2 shows normal caliber common Bile duct.


Perfusion.


Blood pool. Images showed increased tracer uptake in both lungs.


Delayed images (C) also showed increased activity in the lungs and poor uptake in the skeleton.


Bulky condyloma acuminata in the genital area.


Timeline displaying the course of clinical symptoms of case 1.


Erosive esophagitis.


Erosive gastritis.


Sarcina ventriculi in esophageal biopsies. These microorganisms appear to be arranged in tetrads [ 200x.


Sarcina ventriculi in esophageal biopsies. But on higher magnification appear to be arranged in cubes composed of eight individual spheres [ 400x.


Circular gastric ulcer.


Timeline displaying the course of clinical symptoms of case 2.


Posterior dynamic images of Technetium-99m-ethylenedicysteine renogram for a 4-year-old boy, suspected for hypoplastic/ectopic right kidney.


Clinical course of the patient. Cytomegalovirus (CMV) copy numbers in folds of 105 in gray shown as drawn through line; administration of hyperimmune globulines (IVIG), cyclosporine (CsA), prednisolone, rituximab (depicted by crosses) and antiviral medication (ACV: acyclovir; FOS: foscarnet; GCV: ganciclovir; LMV: letermovir; VACV: valacyclovir) as indicated above, dectection of UL56 wild type (WT) is depicted as empty circle and UL56 C325Y as black circle respectively.


ECG upon admission shows sinus rhythm with mild ST-segment elevation in anterior and inferior leads.


Cardiac MRI PSIR- LGE views showing late gadolinium subepicardial enhancement in basal lateral segments in both. Four Chamber.


Short Axis views.


Troponin T level during hospitalization.


TTE images showing mitral valve prolapse with thickening of the mitral valve leaflets suspicious for infective endocarditis.


Severe mitral regurgitation seen on colour flow imaging.


TOE images showing a large mobile friable mass on the posterior mitral valve leaflet suspicious for infective endocarditis (A).


Mitral regurgitation could be seen on the colour flow image (B).


It shows changes consistent with severe colitis due to both graft versus host disease and cytomegalovirus infection.


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). Axials. T1 + Gadolinium.


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). T2-weighted.


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). Gradient echo sequence with a large poli-cystic enhancing selar lesion with extensive osteophytic reaction and invasion of the ipsilateral orbital apex associated with fibrous dysplasia and an enhancing selar mass lesion with their respectively Calcium intensities (white arrows).


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). CT-scans. Axial CT-scan showing the calcified pituitary gland (white arrow).


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). Coronal on bone density revealing thickness of the diploe on the right sphenoid wing (white arrow heads) and osteolytic lesion on the left orbital apex (black asterisk).


Preoperative Brain Magnetic Resonance-Imaging (MRI) and Computed tomography-scan (CT-scan). (F and G) axial and coronal 3D bone reconstruction showing calcified pituitary gland (red arrows) and a calcified rim around the tumor.


CT-scan. Axial slides (A - C) after tumor resection and post operative changes.


Platelet count plot from day 1 to day 60 depicting the drop and return to baseline X-axis: duration in days. Y-axis: platelet count x 105/mul.


Contrast enhanced axial abdominal CT demonstrating primary epiploic appendagitis adjacent to the sigmoid colon 7 months prior to presentation.


Longitudinal abdominal CT with contrast enhancement demonstrating primary epiploic appendagitis adjacent to the sigmoid colon 7 months prior to presentation.


Case 2. Spectral-domain optical coherence tomography (SD-OCT) scan after 3 anti-VEGF injections in the left eye. B SD-OCT scan of right eye. And left eye.


Case 2. Spectral-domain optical coherence tomography (SD-OCT) scan after 3 anti-VEGF injections in the left eye. Revealed photoreceptor dysfunction by showing disruption of the ellipsoid zone (white arrows) with thinning of the outer nuclear layer (white asterisks). B; SD-OCT scan of the left eye showed presence of well-defined hyperreflective material consistent with retinal scar.


Case 4. A, b Color fundus photograph (CFP) of AZOOR 10 years after photodynamic therapy in the right eye. A CFP of the right eye showed extensive macular scarring.


Case 4. B; CFP of the left eye showed peripapillary depigmentation and drusen like material.


Case 4. C; Fundus autofluorescence (FAF) in correspondence of these areas showed a mixed hypo-FAF and granular hyper-FAF signal with a leading hyper-FAF border at the junction between the involved and uninvolved retina (white arrow).


Case 4. D; After one year of follow-up FAF of the left eye revealed minimal progression of the peripapillary zonal lesion in the left eye (yellow arrow).


Abnormal discharge synchronized to the rhythmic jerk located in the right C4-P4. . Note: Red line indicates abnormal discharge synchronized to the rhythmic jerk located in the right C4.


Thyroid ultrasound. (A)
Case 1: transverse view of the right thyroid lobe with an ill-defined hypoechoic area (arrow).


Thyroid ultrasound. (B)
Case 1: longitudinal view of the right thyroid lobe with decreased blood flow within the hypoechoic areas on color-coded Doppler sonography.


Thyroid ultrasound. (C)
Case 2: transverse view of the right thyroid lobe with a distinct hypoechoic area (arrow).


Thyroid ultrasound. (D)
Case 2: transverse view of the right thyroid lobe with decreased blood flow within the hypoechoic area on color-coded Doppler sonography.


Evolution of UTC, salivary F and serum F during follow-up,
normalized by the upper limit normal range (ULNR).


MRI sequences during follow-up. (A) May/2007: coronal view on T 1-weighted MRI of
the pituitary gland identified a heterogeneous solid macroadenoma
(1.9x1.8 cm of diameter - arrow).


MRI sequences during follow-up. (B) August/2013: MRI after four years of
transsphenoidal surgery - questionable remnant tumor tissue or
arachnoid cyst (arrow).


Hyperintense areas in bilateral hippocampal white matter on T2-weighted coronal sections.


Diffuse slow waves superimposed with rapid delta "brush" activity.


Delta "brush" activity localized in the frontal regions in bilateral hemispheres.


Elevtroencephalogram with predominance of diffuse slow waves.


Fluid attenuation inversion recovery axial image at the level of upper medulla shows tiny hyperintense foci in the dorsal aspect of medulla at the caudal end of fourth ventricle - Area Postrema (arrows).


Mid sagittal T2-weighted image shows faint hyperintense linear streak in the dorsal aspect of upper medulla near the caudal end of fourth ventricle (arrow).


Diffusion weighted image shows no restriction.


No enhancement seen on post contrast scan.


Crops of small, red-yellow dome-shaped papules of approx. 6 mm with well-defined borders located on the anterior medial thigh.


Appearance of venous blood following phlebotomy, exhibiting a thick, milky supernatant.


Blood work on the day of admission and blood work on the last day of hospitalization.


A glomerulus showing cellular crescent. The underlying glomerular tuft shows segmental necrosis with fibrin exudation and presence of few karyorrhectic debris (periodic acid - Schiff stain, x400).


Course of the illness and successful response to tacrolimus.


Right eye, 6 days after initial presentation. Three days before this photograph, the eye was examined and no ulceration was found.


Left eye, 6 days after initial presentation. Initially an ulcer with minimal thinning, the marginal guttering has deepened considerably.


Diffusion-weighted image.


Diffusion restriction in bilateral dentate (arrow) nucleus in cerebellum showing corresponding low apparent diffusion coefficient (ADC) value on ADC images.


Hyperintensity noted on T2 fluid-attenuated inversion recovery images.


There are no signal changes seen on T2 weighted images (d).


Immunologcal findings. DIF shows. Immunoglobulin G (IgG).


Immunologcal findings. Complement 3 (C3) deposition along the cell surface of keratinocytes.


Immunologcal findings. (C) Results of immunoblotting of normal human epidermal extracts. Pemphigus vulgaris (PV) control serum reacted with the 160-kDa desmoglein (Dsg) 1 and the 130-kDa Dsg3 (lane 1), paraneoplastic pemphigus (PNP) control serum reacted with the 210-kDa envoplakin and the 190-kDa periplakin (lane 2), bullous pemphigoid (BP) control serum reacted with the 230-kDa BP230 and the 180-kDa BP180 (lane 3), anti-desmocollin (Dsc) monoclonal antibody (mAb) (lane 4) and the patient serum (lane 5) reacted strongly with the 110-kDa a-form and the 100-kDa b-form Dsc3. DIF: direct immunofluorescence.


Head computed tomography (CT) scan revealing a large left extra-axial cystic lesion that was being monitored before current symptomatology.


Head computed tomography (CT) scan showed the pre-existing cystic lesion in the left cerebellopontine angle with a slight right brainstem deviation, without associated edema (
2A), as confirmed by magnetic resonance imagining (MRI) (
2B).


Horizontal section of CT abdomen showing splenic infarct.


Coronal section of CT abdomen showing splenic infarct.


Patient 3. Axial contrast-enhanced orbital CT demonstrates marked swelling of the left medial rectus muscle with a more focal peripherally enhancing mass in the mid-muscle belly (white arrow). There is mild induration of the left retrobulbar fat with slight proptosis.


Two live dirofilarial worms.


Microscopic picture of the worm showing Cuticle and transverse striation.


(a,b) Sagittal and axial T2-weighted MR image shows a large cystic ovarian tumor of 5cm at maximum diameter. The tumor had arisen from the right ovary, the margin was smooth and the uterus was normal size.


(c) Ovarian endometrioid tumor of low malignant potential showing glands similar to the complex hyperplasia of the uterine endometrium.


(a) Brain magnetic resonance venography image obtained on admission showing occlusion of the left transverse and sigmoid sinuses.


(b) 3D TOF MRA showing high-grade left PCA stenosis.


(c) SPECT images obtained on day 2 from ictus showing left posterior ischemic lesion.


Magnetic resonance venography image obtained 28 days after admission showing recanalization of the venous sinus (d).


Improvement in vasoconstriction is observed on day 14 from ictus (e).


SPECT image obtained on day 28 from ictus showing absence of the ischemic lesion (f).


(a,c) Magnetic resonance angiography (MRA) confirmed the presence of a vasospasm involving the right anterior cerebral artery. On admission, MRA revealed vasoconstriction of the anterior cerebral artery. Vasoconstriction was normalized within 3 months.


(b,d) Magnetic resonance venography (MRV) confirmed the presence of a thrombosis involving the superior sagittal sinus. On admission, MRV revealed thrombosis of the superior sagittal sinus, which normalized within 3 months.


CT on admission and 25 months after chemotherapy. Enhanced CT on admission revealed ring enhancement around the periphery of the tumors and heterogeneous enhancement within the tumors (a).


CT on admission and 25 months after chemotherapy. CT also revealed multiple hepatic tumors with heterogeneous enhancement, and a swollen lymph node surrounding the lesser curve of the stomach (b, arrowhead).


CT on admission and 25 months after chemotherapy. Thickening of the stomach wall was indicative of a gastric tumor that was thought to have invaded the muscularis propria (c, arrowheads).


CT on admission and 25 months after chemotherapy. MRI on admission showed enhancement at the periphery of the tumors and heterogeneous enhancement within the tumors in the arterial phase.


CT on admission and 25 months after chemotherapy. , but there was no enhancement during the delayed phase.


CT on admission and 25 months after chemotherapy. CT finding 25 months after chemotherapy showed a remarkable reduction in the size of the metastatic liver tumors without enhancement (f).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD before chemotherapy revealed a Bormann type 3 advanced tumor about 30 mm in diameter in the lower part of the stomach (a).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. Closer view of the gastric tumor (b).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD performed 8 months after chemotherapy showed a remarkable reduction in the size of the tumor, which had the appearance of an excavated lesion with marginal protrusion (c).


Endoscopic findings before chemotherapy and 25 months after chemotherapy. EGD performed 25 months after chemotherapy revealed an even greater reduction in the size of the tumor, which had the appearance of an extremely small elevated lesion with a scar (d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. HE staining revealed that the tumor was a poorly differentiated adenocarcinoma (a). Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. Immunohistochemical evaluation of a tumor biopsy specimen revealed that the tumor cells were positive for AFP Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen. , PIVKA-II Original magnification x400 (a-d).


Hematoxylin and eosin (HE) staining and immunohistochemical findings of the gastric tumor biopsy specimen.HER2 Original magnification x400 (a-d).


Platelet Trends with platelet values reported in thousands/uL for patient with suspected ITP. Day 1 - day 5 were hospitalization days, while days 8 - 46 were collected at outpatient follow-up appointments. Prednisone treatment was initiated on day 1. Day 5 corresponds to the first laboratory value after treatment with intravenous immunoglobulin.


Diffuse petechial rash on the patient's lower extremities (the right lower leg) - day two of hospitalization.


Sheep blood agar plate showing 1-2 mm sized, raised, grayish-white colonies after 48 hr incubation at 37CC, 5%-CO2.


Gram-stained smear of colony on BAP after 48 hr incubation at 37CC showing gram negative coccobacili.


Computed tomography (CT) manifestation of recurrent pulmonary infection. The recurrent pneumonia was observed during the hospitalization.


Computed tomography (CT) manifestation of recurrent pulmonary infection.could be relieved by multiple antibiotic treatments.


Computed tomography (CT) manifestation of recurrent pulmonary infection.


Computed tomography (CT) manifestation of recurrent pulmonary infection. Showed exacerbation of infection before the detection of mycobacterium kansasii (with air bronchogram and pulmonary consolidation), and the situation did not get improved after multiple treatments.


Dark red, necrotic, slightly tender lesions developed symmetrically on MCP joints and knees.


Hematoxylin and eosin (HE) staining shows blood vessels (white areas) with surrounding neutrophilic inflammatory aggregates (arrows), establishing the diagnosis of neutrophilic vasculitis. Picture magnification: 20x; scale bar: 50 mu.


A-C-D show a lateral view of the patient affected by lipodystrophy with particular accumulation of adipose tissue in the region of the neck and trunk. Fig. 2B shows a posterior view.


Chest x-ray shows the ovalization of the tracheal lumen (arrow).


Magnetic resonance imaging of brain showing isointense sellar lesion with enhancement of pituitary stalk.


Magnetic resonance imaging of brain showing uniform enhancement of sellar lesion in contrary to ring enhancement seen in tuberculoma.


Incision of the right corpus cavernosum contributed to drainage of a large amount of pus.


Extra-oral photograph shows protruding mandible and hypotelorism.


Intra-oral photograph shows malformed dentition with pulpal exposure of all teeth in the maxillary arch.


Intra-oral photograph shows partial ankyloglossia (arrow).


Orthopantomograph shows multiple unerupted teeth and missing permanent tooth germs (black arrow), short roots (white arrow), and enlarged pulpal chambers (dashed arrow).


Extra-oral photograph shows dolicocephalic, hypoplastic maxilla (white arrow), with anti-mongoloid features (black arrow).


Medical image.


Intra oral photograph of the maxillary arch shows multiple missing teeth. Intra oral photograph shows ankyloglossia (arrow), widely spaced, discolored, and malformed teeth.


Orthopantomograph shows multiple impacted teeth, multiple missing permanent tooth germs, retained teeth (arrow), short roots (arrow), and enlarged pulp chambers (arrow).


Hand-wrist radiograph shows incomplete capping of the epiphysis of the mid phalanx (small arrow) and incomplete fusion of the epiphysis and diaphysis of the radius (large arrow).


Significantly decreased FDG uptake on PET/CT was seen 3 months after intensive treatment.


Chest radiograph and chest HRCT scan on admission. (A) showed patchy shadows in the right lung (arrows) and the lower left lung (arrow).


Chest radiograph and chest HRCT scan on admission. (B and C) Multiple masses and small nodules over both lungs (arrows). . Abbreviation: HRCT, high-resolution computed tomography.


Chest HRCT scan after 12 months of antibiotic therapy. (A and B) Most of the lung lesions are absorbed, but there were still some strip shadows in both lungs (arrows). . Abbreviation: HRCT, high-resolution computed tomography.


Cerebrospinal fluid (CSF) studies: CSF opening pressure, glucose, and WBC count over the course of initial hospitalization with initiation of steroids on day 13 (red arrow).


Corneal perforation and iris protrusion in the right eye.


Corneal perforation and iris protrusion in the left eye.


Eccentric penetrating keratoplasty of the right eye.


Corneal patch grafts and amniotic membrane transplant of the left eye.


Large diameter penetrating keratoplasty of the left eye.


Mature cataract OS prior to surgery (Case 1).


Pseudophakia OS 8 weeks after surgery. Concentric rings from the optical portion of the IOL can be noted in this image (Case 1).


Variation of total billirubin and hematocrit of both the twins (arrow represents the transfusion received by them).


Anti-M alloantibody titre variation in mother and twins.


With right calf fasciotomy.


Surgical debridement of the right foot ulcer.


Right leg Ischemic and evidence of Gangrene.


Destroyed tricuspid valve with vegetations and necrotic tissues.


PFM coil removed.


Tissue valve implanted in the tricuspid position.


Mucosal ulcers. Oral mucosal aphthous ulcers.


Mucosal ulcers. Penile ulcer.


Light microscopy imaging of the renal biopsy demonstrating a small vessel vasculitis. Original magnification x400, using Haematoxylin-eosin stain.


Light microscopy imaging of the renal biopsy demonstrating a medium sized vasculitis. Original magnification x100, using Haematoxylin-eosin stain.


Magnetic resonance image showing a high signal intensity and enhancement in head of proximal radius. Synovial hypertrophy and fluid collection in elbow joint.


(A) Multiple translucent skin-colored, bluish cystic lesions in periorbital distribution, cheeks, and zygomatic region.


(B) Unilocular cyst lined by two layers of flattened cuboidal epithelium without any evidence of decapitation in lining cells (hematoxylin and eosin, x40 magnification).


(C) Whitish clod (yellow arrow) without crater seen on dermoscopy (nonpolarized mode, x170 magnification).


(D) Yellowish globules (blue arrow) with multiple telangiectasias (white arrow) seen on dermoscopy (polarized mode, x170 magnification).


Hematoxylin and eosin stain of a duodenal biopsy specimen showing inflammatory cell infiltrate, marked blunting of villi and Strongyloides stercoralis larvae (x100).


Longitudinal and cross-sectional view of a duodenal biopsy specimen stained with hematoxylin and eosin showing several S. stercoralis larvae lying within a crypt (x40).


Transesophageal echocardiogram showing vegetation/mass noted on septal leaflet of the Tricuspid Valve. RA: Right atrium, LA: Left atrium, RV: Right ventricle.


Transthoracic echocardiogram image showing side by side 2-dimensional and color doppler imaging of membranous septum without VSD. RA: Right atrium, LA: Left atrium RV: Right ventricle, AoV: Aortic Valve.


Transesophageal echocardiogram image showing side by side 2-dimensional and color doppler imaging of IE created defect. LV to RV to Anterior septal commissure of tricuspid valve to RA. RA: Right atrium, LA: Left atrium, RV: Right ventricle, LV: Left ventricle, VSD: Ventricular septal defect.


Intraoperative image from the surgeon's viewpoint looking at the tricuspid valve from the right atrial position. The septal leaflet is being held by forceps, and a vegetation is notable in the abscess cavity where the ventricular septal defect begins.


Intraoperative image from the surgeon's viewpoint. Splayed ascending aorta looking at the aortic valve showing erosion of the noncoronary cusp of the aortic valve.


Chest computed tomography scan. Bronchiectasis and multiple granular shadows are randomly distributed in the bilateral lobes, and consolidation in the lower left lobe is present.


Flow cytometric analysis of phosphorylationed STAT1 (pSTAT1) in monocytes after the stimulation with interferon-gamma (500 U/mL). The analysis gate was set in CD14+ cells. Blue areas indicate healthy adults (n = 3), whereas pink areas indicate the patient. Gray and purple areas indicate pSTAT1 in monocytes without interferon-gamma stimulation in healthy adults and the patient, respectively.


Preoperative findings. A; Anterior segment photography obtained before the procedure reveals a freely movable conjunctival cyst (black arrow); b Anterior segment optical coherence tomography (AS-OCT) reveals a subconjunctival cyst filled with homogenous fluid (white arrow).


A; Family 1, case 1: erythematous, papular lesions of the palms mimicking erythema multiforme or secondary syphilis.


B; Family 1, case 1: papular enanthem of the oral cavity.


C; Family 1, the child: onychomadesis of a fingernail 2 months after Coxsackievirus A6 infection.


D; Family 2, case 3: erythematous, papulovesicular lesions of the right foot.


Gram-stain of bronchoalveolar lavage. Black arrows indicate capsulated Gram-negative large rod.


Multiplex PCR. The isolated strain possessed iutA, rmpA, entB, and mrkD.


Pilonidal abscess, sagittal computed tomography (CT) images on admission (A) CT scan showing soft-tissue ill-defined thickening from the lumbar spine to the sacrum, with a focal well-defined fluid collection measuring approximately 2.9 x 0.8 cm (arrow).


Time of neutrophil recovery (B) Three weeks postinduction CT sagittal images showing increase in well-defined fluid collection, now measuring 1.3 x 2.2 x 6.4 cm (marked with arrow).


(A) Magnetic resonance imaging (MRI) T2 coronal images with marked edema and enhancement of the left adductor magnus and brevis muscles, with focal areas of nonenhancement consistent with myonecrosis (arrow).


(B) MRI T1 fast-spin coronal images with progression of the edema and development of a fluid collection in the proximal medial thigh measuring 3.9 x 10.3 x 8.5 cm (marked with arrow).


Axial T2-weighted magnetic resonance image shows progressive multifocal leukoencephalopathy with a large confluent hyperintense lesion in the left occipitotemporal region.


Axial T2-weighted, fluid-attenuated inversion recovery magnetic resonance image shows progressive multifocal leukoencephalopathy with a high signal intensity lesion involving the white matter of the dorsal right frontal lobe and right frontal operculum, as well as lateral left frontal and inferior left occipitotemporal region with no mass effect.


T2-weighted MRI revealed a distinct tiger-striped appearance with abnormally oriented folia in the left cerebellar hemisphere, extending to the vermis.


The cerebellar lesion exhibited a hyperperfusion on blood flow imaging (upper left) and a hypermetabolism on the metabolic rate of oxygen imaging (upper right), respectively, on 15O-gas PET. 99mTc-ECD (lower left) and 123I-iomazenil (lower right) SPECT show hyperactivity and a defect in the uptake of the lesion.


Surgical resection of the tumor. Tumor of 35 x 30 x 17 mm.


Photo of the tumor at low magnification (X50). Nodular and well limited tumor composed of sheets of eosinophilic cells with Hematoxylin Eosin and Saffron (HES) stain.


Photo of the tumor at high magnification (X200). Tumor cells are large with an abundant eosinophilic cytoplasm and round regular nuclei with small nucleoli, according with Leydig cells. Hematoxylin Eosin and Saffron (HES) stain.


Photo of the tumor at high magnification (X400). Tumors cells were diffusely stained with antibody to inhibin A(immunoperoxydase). All tumor cells present a diffuse and strong cytoplasmic staining.


Photo of the testicular biopsy at high magnification (X100). Histopathological micrograph with hematoxylin-eosin-green FCF stain. The testicular biopsy consists of tubules with hypospermatogenesis (white arrows) mixed with aplasia (black arrows).


Testicular Steroidogenesis.


Illustration of treatment escalation in refractory course of anti-NMDA receptor encephalitis with special focus on antibody titer in CSF and serum as well as the clinical development over 27 months. mRS: modified Rankin scale (0, No symptoms; 1, No significant disability; 2, Slight disability, able to look after own affairs without assistance, but unable to carry out all previous activities; 3, Moderate disability. Requires some help, but able to walk unassisted; 4, Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted; 5, Severe disability. Requires constant nursing care and attention, bedridden, incontinent, 6 - Dead).


Level of immunoglobulin classes and influence of daratumumab. (A) Immunoglobulins in serum.


Level of immunoglobulin classes and influence of daratumumab. (B) Immunoglobulins in CSF.


3D reconstruction with a catheter in the common hepatic artery (asterisk) and six electrodes placed alongside the metallic Wallstent.


Buckle infection by Serratia marcescens. (a) Explanted scleral buckle showing reddish-brown deposits over the exposed portion of the buckle.


Buckle infection by Serratia marcescens. (b) Scleral thinning with underlying uveal tissue noted.


Buckle infection by Serratia marcescens. (c) Growth on both chocolate and blood agar.


Buckle infection by Serratia marcescens. (d) Microscopic image showing Gram-negative rod-shaped bacillus identified as Serratia species.


(A) The blood cell and PCM1-JAK2 fusion transcript changes in patient 1 over the course of the disease.


(B) The blood cell changes in patient 2 over the course of the disease. WBC, white blood cells; HB, hemoglobin; PLT, platelet; Eo, eosinophils.


Ultrasound examination images. A; Ultrasound examination result at 30wk. A ventricular septal defect for 2.2 mm was shown as the arrow in the image. Abbreviations: LA, left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle; VSD, ventricular septal defect.


Ultrasound examination images. B; Ultrasound examination result at 33wk. A ventricular septal defect (VSD) for 3.0 mm was shown as the arrow in the image.


Onset of NCSE (thick arrow) on initial EEG after admission. This epoch of the EEG shows onset of NCSE with diffuse slowing of 2- to 2.5-Hz delta and left greater than right hemispheric spikes (thin arrows).


The antibiotic susceptibility plate showing no zone of inhibition around the linezolid E-test strip along with the susceptibility pattern for other antibiotics by Kirby Bauer disc diffusion method for the linezolid resistant enterococcus isolate.


Clinical case 3: Images shown of the RE (left panel) and LE (right panel). Retinography (top panel of images), fluorescein angiography (middle panel of images) and SD-OCT (bottom panel of images). The most relevant OCT characteristics included the presence of outer photoreceptor segment disruption, dOPL, presence of central confluent ONLc and INLc, with a relatively equivalent distribution of cysts between both nuclear layers in both eyes. The case shows recurrent DME as the patient case was responsive to IVI of triamcinolone and PRP. Patient lived a long way from the hospital, had PDR in the LE (ie the non-vitrectomized eye).


Family pedigree.


Admission chest x-ray shows bilateral infiltrates and chronic emphysematous changes.


Admission chest computed tomography, transverse view of upper lobes, shows dominant right upper lobe intracavitary lesion. The central component is 2.1 x 2.3 cm (previously 2.0 x 2.3 cm). The mural nodule within this cavitation is 2.1 x 1.2 cm (previously 1.5 x 1.0 cm) and thin walled. Imaging shows progression of right upper lobe bullous emphysema and cystic bronchiectatic changes.


Admission chest computed tomography, transverse view of lower lobes, shows new onset diffuse interstitial pulmonary ground-glass airspace opacities.


Admission chest computed tomography, coronal view, shows increased mediastinal lymphadenopathy, likely reactive.


Follow-up chest computed tomography after 5 weeks, transverse view of upper lobes, shows the mural nodule in the right upper lobe intracavitary lesion at 3.1 cm and partially calcified.


Follow-up chest computed tomography after 5 weeks, transverse view of lower lobes, shows near complete clearing of bibasilar opacities. Bilateral partially calcified nodules and amorphous/nodular opacities (more on the right than on the left) are visible, as well as bilateral bronchiectasis (also more on the right than on the left).


Follow-up chest computed tomography after 5 weeks, coronal view, shows stable borderline mediastinal lymphadenopathy.


Chest X-ray of patient on admission to local hospital post-intubation.


Schematic overview of the timing and dosing of the BV-DHAP regimen. . Notes: Dosage in cycle 1 was reduced to 75%. Cycle 2 was administered at 100% as indicated. . Abbreviations: BV-DHAP, brentuximab vedotin and cisplatin/cytarabine; d, day; iv, intravenous; po, per os; sc, subcutaneous.


CT abdomen showing asymmetric gastric mucosal thickening.


Pathology H&E stains of core biopsy. Spindle cells are seen.


CT chest showing bilateral pleural effusions and moderate pericardial effusion with dilated cardiomyopathy.


Renal pathological presentation (kidney biopsy of the proband 15 days after admission). Brightfield microscopy (PAS stain x600). Mesangial, and ,endocapillary hypercellularity.


Renal pathological presentation (kidney biopsy of the proband 15 days after admission). Brightfield microscopy (PAS stain x600). Cellular crescent.


Renal pathological presentation (kidney biopsy of the proband 15 days after admission). Brightfield microscopy (PAS stain x600). Segmental scar/fibrous crescent.


Renal pathological presentation (kidney biopsy of the proband 15 days after admission). Brightfield (H & E stain x200). Interstitial infiltrates.


Renal pathological presentation (kidney biopsy of the proband 15 days after admission). Immunohistochemistry (x200). Interstitial infiltrates.


Renal pathological presentation (kidney biopsy of the proband 15 days after admission). Electron microscopy. Diffuse podocyte foot process effacement with prominent microvillous transformation.


Negative-pressure wound therapy with continuous instillation (NPWT-CI).


Hematoxylin and eosin (H&E) staining and immunohistochemical analyses of the resected tumor. (A) The tumor cells arrange in a diffuse pattern(x4). Melan-. Patchy).


Hematoxylin and eosin (H&E) staining and immunohistochemical analyses of the resected tumor. (B) Epithelioid tumor cells are oval or polygonal, with clear or granular eosinophilic cytoplasm. Nucleoli are prominent in the vesicular nuclei. Increased mitotic activity and dysplasia are observed (x20).


Hematoxylin and eosin (H&E) staining and immunohistochemical analyses of the resected tumor. Tumor cells are positive for. HMB-45 (strong, and ,diffuse).


Hematoxylin and eosin (H&E) staining and immunohistochemical analyses of the resected tumor.


Hematoxylin and eosin (H&E) staining and immunohistochemical analyses of the resected tumor.
TFE3 (modest, and ,diffuse).


Hematoxylin and eosin (H&E) staining and immunohistochemical analyses of the resected tumor. Are negative for. SMA.


(a) Gadolinium contrast-enhanced magnetic resonance imaging demonstrated inflammation of vertebral body at L3 and L4 with bilateral iliopsoas abscesses.


(b) Microscopy of the surgical specimen of the vertebral interbody revealed granuloma aggregating of histiocytes by hematoxylin and eosin staining at low magnification. A punctured specimen from the abscess of iliopsoas muscle demonstrated Mycobacterium tuberculosis in the Ziehl-Neelsen stain at high magnification (left upper).


Operative view: A lesionectomy was performed by opening the cerebellomedullary fissure, and a well-circumscribed mass with gray color encircled by arrowhead was identified (left).


Total mass resection was performed (right).


(a) Operative view: A lesionectomy was performed by opening the cerebellomedullary fissure, and a well-circumscribed mass with gray color encircled by arrowhead was identified (left). Total mass resection was performed (right). The size of the extracted mass was 3.5 cm. Pathology of the lesion revealed lymphocytes, macrophages, plasmacytes, and neutrophils aggregated around the tuberculoma by hematoxylin and eosin staining at 200-fold magnification (upper left).


(b) Postoperative MRI showed a total mass resection.


(H&E x100).


(H&E x200).


The cells demonstrate round to oval nuclei with variably prominent nucleoli, moderate eosinophilic cytoplasm and indistinct borders (C) (H&E x400).


The cells demonstrate irregular nuclei with prominent multiple eosinophilic nucleoli, abundant eosinophilic cytoplasm and indistinct borders (D) (H&E x400).


Bladder wall tumor): A highly cellular epithelioid (top right) and spindle cell (bottom left) malignancy involving the outer wall of the urinary bladder Immunohistochemistry shows diffuse reactivity for cytokeratin AE1/AE3 and calretinin (inset) (E) (IHC x100).


Remote abdominal tumor): A moderately cellular malignancy with intermixed spindled and epithelioid cells involving the outer gastric wall Immunohistochemistry shows reactivity for cytokeratin AE1/AE3 and negative calretinin (inset) (F) (IHC x100).


Levels of von Willebrand factor VIII Ag and Ristocetin Cofactor activity. (In the X axis, days from episode of bleeding is shown, while in the Y axis levels in U/mL are recorded).


Computed tomography scan shows the lesion, located in meta-diaphysial area.


Primary giant cell tumor of bone (Haematoxylin and Eosin).


MRI images (FLAIR) performed one month after the patient was bitten; hyperintensities in the basal ganglia (white arrows), thalamus, pons, and medulla.


Brain atrophy. Are shown.


Patient monitoring data are displayed as ICP (gray-filled line), gastroparesis (black line), and interventions: Salovum (black bar), Pentothal (gray bar). Critical ICP threshold according to the TBI algorithm (20 mm Hg) and threshold for gastroparesis are shown by horizontal black line. Patient 1.


Patient monitoring data are displayed as ICP (gray-filled line), gastroparesis (black line), and interventions: Salovum (black bar), Pentothal (gray bar). Critical ICP threshold according to the TBI algorithm (20 mm Hg) and threshold for gastroparesis are shown by horizontal black line. Patient 2.


Patient monitoring data are displayed as ICP (gray-filled line), gastroparesis (black line), and interventions: Salovum (black bar), Pentothal (gray bar). Critical ICP threshold according to the TBI algorithm (20 mm Hg) and threshold for gastroparesis are shown by horizontal black line. Patient 3.


Patient monitoring data are displayed as ICP (gray-filled line), gastroparesis (black line), and interventions: Salovum (black bar), Pentothal (gray bar). Critical ICP threshold according to the TBI algorithm (20 mm Hg) and threshold for gastroparesis are shown by horizontal black line. Patient 4.


Patient monitoring data are displayed as ICP (gray-filled line), gastroparesis (black line), and interventions: Salovum (black bar), Pentothal (gray bar). Critical ICP threshold according to the TBI algorithm (20 mm Hg) and threshold for gastroparesis are shown by horizontal black line. Patient 5.


Timeline course of the patient's COVID-19 disease.


(A) Selected cases of Ewingella americana infection. Examples of clinical presentation after E. Americana infection with the associated antibiogram. To note, the prevalence of immunocompromised patients and the presence of only three previously reported pediatric cases (case n.1, 2, and 3). TMP/SMX, Trimethoprim/sulfamethoxazole; CKD, Chronic kidney disease; COPD, Chronic obstructive pulmonary disease.


(B) Clinical and laboratory findings in a newborn with E. Americana meningitis.


Antimicrobial susceptibility results of E. americana in our patient.


Heterogenous tumor within the right cerebello-pontine angle causing severe compression of the brainstem. This T2-weighted MRI image in the transversal plane illustrates the extrinsic nature of the lesion with a differential diagnosis of meningioma or Schwannoma.


Pedigree of the family with the SMARCE1 mutation. Current age is mentioned below the square/circle. + = mutation positive, - = mutation negative. Solid black = CCM patient, age of detection of CCM is mentioned below the current age. Solid white = clinically asymptomatic. ? = testing not started yet.


(A and B) Moderate-to-severe psoriasis, with a Psoriasis Area and Severity Index (PASI) score of 16, body surface area (BSA) score of 12 and Dermatology Life Quality Index (DLQI) score of 18 prior to treatment with biological therapy.


(C and D) Complete clinical response after 16 weeks of secukinumab.


Progression of diabetic tractional retinal detachment, by fundus photography and optical coherence tomography (OCT) of the left eye after a unilateral, right eye intraoperative intravitreal bevacizumab injection. . Notes: Fundus photograph.


Progression of diabetic tractional retinal detachment, by fundus photography and optical coherence tomography (OCT) of the left eye after a unilateral, right eye intraoperative intravitreal bevacizumab injection. OCT. Of the left eye before right eye intraoperative intravitreal bevacizumab injection, showing vitreoretinal adhesions and attached macula.


Progression of diabetic tractional retinal detachment, by fundus photography and optical coherence tomography (OCT) of the left eye after a unilateral, right eye intraoperative intravitreal bevacizumab injection. Fundus photograph.


Progression of diabetic tractional retinal detachment, by fundus photography and optical coherence tomography (OCT) of the left eye after a unilateral, right eye intraoperative intravitreal bevacizumab injection. OCT. Of the left eye after right eye intraoperative intravitreal bevacizumab injection, showing decreased perfusion of the neovascular tissue and progression of tractional retinal detachment.


Chest X-ray showing pulmonary congestion.


Transthoracic echocardiogram, parasternal L-A view showing the anterior leaflet saccular aneurysm of the mitral valve.


Transesophageal echocardiography, 4-C mid-esophageal view showing the perforated anterior leaflet aneurysm of the mitral valve.


Transesophageal echocardiography image demonstrating the anterior-posterior bicuspid aortic valve.


Flash-evoked visual potentials show prolonged N2 and P2 latencies in both sides at 9 months after disease onset.


Marked improvement 9 months later.


3T MRI coronal T2-weighted images show increased signals in both optic nerves, more prominent on the right (e).


Brain MRI at neurological presentation shows multifocal hyperintense lesions within the basal ganglia.


Midbrain.


Significantly reduced lesion load after 9 months.


Axial.


Coronal. Brain 18F-FDG PET slices showing reduced glucose uptake in the left caudate nucleus, putamen, thalamus and bilateral mesial temporal lobes.


Color fundus photograph of the left eye. (a) At presentation, the left eye shows a subretinal mass approximately of 1.5-disc diameter in size located near superotemporal arcade with surrounding subretinal fluid extending till fovea.


Color fundus photograph of the left eye. (b) At 2-week follow up, the choroidal tuberculoma did not show any significant change in the size.


Color fundus photograph of the left eye. (c) At the last follow-up visit, a regressed and partially scarred tuberculoma is seen.


Fundus fluorescein angiography of the left eye at 10 weeks of presentation. (a) A small area of hypofluorescence overlying the lesion surrounded by hyperfluorescence in the early phase.


Fundus fluorescein angiography of the left eye at 10 weeks of presentation. (b and c) There is progressive staining of lesion in the late phase.


Gel column hemagglutination with IgG weak positive reaction.


The variation of the tumor and inflammation in Chest CT. Pre-immunotherapy: the tumor was seen in the right lung.


The variation of the tumor and inflammation in Chest CT. 2 weeks after immunotherapy: patchy shadows appeared around the tumor, and ,air holes occurred in the tumor.


The variation of the tumor and inflammation in Chest CT. 4 weeks after immunotherapy: more air holes developed in the tumor, and ,patchy shadows.


The variation of the tumor and inflammation in Chest CT. 5 weeks after immunotherapy: the tumor, and ,patchy shadows were dissipating.


The variation of the tumor and inflammation in Chest CT. 8/12 weeks after immunotherapy: the tumor disappeared, with several linear shadows leaving.


The variation of the tumor and inflammation in Chest CT. 16 weeks after immunotherapy: the tumor reappeared in original site.


The variation of the tumor and inflammation in Chest CT. 18 weeks after immunotherapy: the tumor enlarged.


Myositis: the level of serum creatase was used to monitor immune related myositis after immunotherapy.


Myocarditis+ Hepatitis: cardiac markers, and ,hepatic transaminase were used to monitor myocarditis, and ,hepatitis, respectively, after immunotherapy.


Pituitary-Adrenal Axis: the level of COR, and ,ACTH were used to monitor the function of the pituitary-adrenal axis: COR, and ,ACTH both declined remarkably after ICI therapy, ACTH was maintained at a low level while COR was still lower than the normal value by glucocorticoid replacement therapy.


Pituitary-Gonad Axis: the level of FSH, LH, and ,TESTO were used to monitor the function of the pituitary-gonad axis: all of them fluctuated in the range of normal values, TSH, and ,FT4 were both normal in the pituitary-thyroid axis.


Autoimmune Reponse: IL-6, and ,TNF-alpha was used to monitor the autoimmune response induce by ICI: IL-6 fluctuated beyond the upper limit of normal (ULN) while TNF-alpha fell to normal gradually after glucocorticoid replacement therapy.


Tumor Marker: tumor markers was used to monitor efficacy of ICI.


The patient with fluctuant, tender nodules with overlying alopecia. (A and B) Posterior and lateral views to show enlarged nodules in the scalp.


(A) Before treatment.


(B) After 2 months of therapy showing partial hair regrowth.


Fundus photograph after initial treatment. Note the decreased vitritis, media haziness, and disk edema. A white linear subretinal lesion (nematode) is present in the inferonasal quadrant (white arrow) as well as a white intravitreal substance corresponding to the triamcinolone acetonide particles (black arrow).


Fundus photograph after worm mobilization.


Optical coherence tomography demonstrates the subretinal location of the worm presenting as two hyper-. reflective particles over the retinal pigment epithelium (white arrows).


Fundus photograph immediately after application of laser photocoagulation to the nematode.


Image of patient exhibiting edematous erythema, ulcer, and necrosis over the right nasal alae and upper lip.


Microscope image of biopsied lesion tissue showing numerous hyaline and septate hyphae with branches at acute angles scattered in the dermis (arrowhead) (periodic acid-Schiff, original magnification x 400).


Blood cell counts during hospitalization.


Clinical presentation of the case with IL12RB1 deficiency. Pictures were taken on different occasions:. Skin lesion in the form of multiple erythematous maculo-papular rash, over the upper limbs.


Clinical presentation of the case with IL12RB1 deficiency. Pictures were taken on different occasions: , lower limbs.


Clinical presentation of the case with IL12RB1 deficiency. Pictures were taken on different occasions: over the abdominal wall surrounding the umbilicus.


Clinical presentation of the case with IL12RB1 deficiency. Pictures were taken on different occasions: (D) A swelling is shown in the left groin, due to left inguinal lymphadenitis (arrowed).


Right thumb showing worsening cutaneous erythema and roughening of the eponychia.


Biopsy prepared with haematoxylin and eosin stain (20x magnification).


Timeline.


Family tree.


Diagnostic imaging. Echocardiography (A, B) showed a hypoechoic mass in the left ventricle and the anterolateral right ventricle.


Diagnostic imaging. Chest CT scan mediastinal window (C, D) with contrast enhancement showed that the heart shadow had increased. A round, soft-tissue mass was observed at the left edge of the Cardiac margin. Multiple lymph node shadows were observed at the left hilum of the lung and mediastinum.


Diagnostic imaging. The chest CT scan lung window (E, F) showed right pleural effusion and bilateral pneumonia.


Right paraventricular mass biopsy (200x). The H&E stain (A, B) showed poorly differentiated carcinoma infiltration in fibrous tissue.


Right paraventricular mass biopsy (200x). The immunohistochemical analysis (C-H) showed EGFR (+), CK (+), P63 (+), Ki67 (40%+), PD-L1 (CPS 80%+), and PD-L1.


Creatinine level changes.


Fifteen year-old tattoo made of black pigment with erythematous and painful infiltrative reaction with papules and plaques.


Contrast CT-scans performed during targeted therapy. Showing enlarged mediastinal lymph nodes.


After the definitive suspension of treatment showing reduction in the diameter of the previously reported lymph nodes.


The timeline of patient's treatment history and the response of the tumor lesions. Time line.


The timeline of patient's treatment history and the response of the tumor lesions. The radiographic imaging of pancreatic and metastatic liver lesions.


Schematic of the mutant genome. The in-frame deletion is not affecting the ORFS, but shortens pre-S2 and Pol by the corresponding two amino acids. A total of 1,380 truncates the polymerase to 82 amino acids.


During interictal EEG, diffuse irregular high amplitude slow waves of bilateral symmetry were found.


(A) Glomeruli show a lobular flocculus with a global and diffuse endocapillary proliferation associated with mesangial hypercellularity. Crescents with fibrinoid necrosis were present (arrow) (Trichrome stain: original magnification: 400x).


(B) By immunofluorescence, IgG deposits were diffusely observed and organized in a starry sky pattern (FITC: original magnification: 400x).


(C) Numerous subepithelial (humps) and mesangial dense deposits were observed by electronic microscopy. Arrow shows so called humps.


By immunofluorescence,. C3.


By immunofluorescence,. C5-9. Deposits were diffusely observed (FITC: original magnification: 400x).


Cerebral and cerebellar atrophy, deepening of the cerebral sulci on cranial computed tomography in case 3.


Appearance of bilateral paramediastinal infection on computed tomography of the thorax suggesting invasive fungal infection in the lung in case 4.


Homozygous nonsense mutation in exon 6 (c.700 C>T) (P. Arg234Ter) in the purine nucleoside phosphorylase gene in case 4.


T1-weighted images coronal: Well-defined cerebrospinal fluid signal intensity in prepontine, interpeduncular, suprasellar, anterior third ventricle with dilatation of third and both lateral ventricles.


T1-weighted images axial: Well-marginated cerebrospinal fluid signal intensity cystic lesion in prepontine, interpeduncular, suprasellar, anterior third ventricle with moderate dilatation of third and both lateral ventricles.


T1-weighted image axial: Ventricular dilatation has significantly decreased with near normal size ventricles.


T2 sagittal: Gross dilatation of body of lateral and third ventricle with fenestrations of cyst at superior and inferior aspect.


Cyst bulging into foramen of monro.


Thinned out third ventricular floor.


Minimal decrease in cerebrospinal fluid density cystic lesion and obstructive hydrocephalus.


(a) Ultrasound image of the brachial plexus between the anterior and middle scalene muscle.


Arrows indicate brachial plexus (BP); (b) Ultrasound image of spreading the drugs around the brachial plexus. Arrowheads indicate the needle. Arrows indicate BP. ASM anterior scalene muscle, MSM middle scalene muscle, SCM sternocleidomastoid muscle, * injected drug surrounding the BP.


Picture of severe bruise after fall due to dizziness of adverse effect of medication in Case 2.


Ultrasound image of the lumbar plexus block in the posterior part of the psoas muscle (PM). Arrows indicate lumbar plexus (LP). Arrowheads indicate the needle. ESM erector spinae mescle, PM psoas muscle, TPL4 transverse process of L4, TPL5 transverse process of L5.


Patient A: preoperative, axial T1 postcontrast weighted magnetic resonance (MRI) imaging showing enhancing disease.


Postoperative, axial T1 postcontrast weighted MRI imaging showing enhancing, residual disease.


Radiation therapy (RT) planning using volumetric arc therapy (VMAT) resulted in excellent coverage of the planning target volume (PTV) (red) by the 100% isodose line (yellow) corresponding to 5940 cGy.


Follow up gallium-68 dotatate positron emission tomography (PET) after more than 6 years showing hypermetabolic, recurrent disease in the left tentorial leaflet and physiologic uptake in the pituitary.


Patient B: preoperative, axial T1 postcontrast weighted MRI imaging showing enhancing disease.


Postoperative PET showing hypermetabolic, residual disease.


RT planning using VMAT resulted in excellent coverage of the 6000 cGy (red) and 5400 cGy (blue) PTVs by the 100% (yellow) and 90% (green) isodose lines, respectively.


Biallelic inactivation of BAP1 by differing mechanisms. Aligned sequence data from Patient A show the pathogenic BAP1 variant is heterozygous in the germline (top track) and tumor (bottom track).


Biallelic inactivation of BAP1 by differing mechanisms. ; the second hit is a somatic frameshift mutation.


Biallelic inactivation of BAP1 by differing mechanisms. In contrast, aligned sequence data from Patient B.


Biallelic inactivation of BAP1 by differing mechanisms. Show the germline variant approaching homozygosity in the tumor VarScan tumor allele frequency plot for heterozygous germline variants on chromosome 3 of Patient B indicates chromosome-level LOH across chromosome 3.


Computed tomography of the chest one day after admission to the intensive care unit showing bilateral infiltrates and airspace consolidation of the left lower lobe.


Tc-99m MDP whole body images show multiple sites of increased tracer uptake, including the skull and facial bones, multiple ribs, pelvis and bones of both lower limbs. The "pirate sign" indicates involvement of the right sphenoid wing.


Non-contrast CT scan of the chest shows bony expansion and deformity of the right ribs, where intense osteoblastic activity was detected.


PET-CT scan showing no FDG uptake in the pleura.


CT scan showing pneumothorax and centrilobular nodular shadows with ipsilateral increasing pleural effusion.


T2 weighted lumbar sagittal MRI view demonstrating spinal stenosis at L4-L5 and L5-S1.


PA x-ray of lumbar spine demonstrating adequate contrast spread at the right L4 nerve root.


Head CT showing a large right parieto-occipital hemorrhage with edema secondary to the septic embolus. Note also the presence of marked mass effect as indicated by obliteration of the occipital pole of the right lateral ventricle.


Crusted VZV lesions (sacrum) and reddish-blue painful lesion on left buttock.


Chest X-Ray showing pulmonary infiltrates and cardiomegaly.


Echocardiography showing prolapse of mitral valve (arrow).


Computed tomography (CT) thorax showing the sternoclavicular mass as indicated by the two arrows.


X-ray of the left elbow joint shows osteomyelitis and destruction of the joint as indicated by the arrow.


Digital subtraction angiography of left subclavian artery of the patient. Digital subtraction angiography of the patient performed sixteen months after the initial presentation revealed significant stenosis of the left subclavian artery and stenosis at the origin of left vertebral artery. Other major branches of aorta including renal arteries were normal.


Showing multiple papules, pustules over the forearms.


A low-power histopathological photograph showing neutrophilic infiltration (arrow) around eccrine glands with necrosis.


Ulcers covered with pus and slough seen over the left side of the neck, left axilla and lateral chest wall.


Non pigmented.


Smooth colonies on Lowenstein-Jensen medium on 7th day of inoculation at 37 C. Ziehl-Neelsen stain of the culture showing acid fast bacilli.


Surgical view of the reconstructed RA. (A) Resection of infected RA tissue.


Surgical view of the reconstructed RA. (B,C) RA reconstruction using autologous LAA.


Surgical view of the reconstructed RA. (D) The reconstructed RA. Right arrow, infected RA tissue; blue arrow, LAA.


Post-operative findings in a patient with infective endocarditis and paravascular abscess of the RA. (A) Immediately postoperative TTE of the RA and TCV.


Post-operative findings in a patient with infective endocarditis and paravascular abscess of the RA. (B) TTE showed no shrinkage of the reconstructed RA 6 months after surgery.


ECHO view of vegetative growth over the mitral posterior leaflet (arrow).


Abdominal CT view of encapsulated hypodense splenic lesion suggestive of splenic infarction (arrow).


Brain MRI view of lesion suggestive of brain infarction with bright signal intensity on diffusion-weighted.


Contrast-enhanced T1-weighted. Images in the right fronto-parieto-occipital cerebral area (arrows).


Enhanced abdominal CT scan findings. (A) Enhanced abdominal CT on admission. Around the head of the pancreas, the density of the adipose tissue was increased. There was a fluid collection but no swelling of the pancreas (arrow).


Enhanced abdominal CT scan findings. (B) Abdominal CT on hospital day 11. The fluid collection has disappeared and there were no cystic changes in the pancreas.


Clinical Course. PAM: pralidoxime methiodide, ABPC/SBT: Sulbactam/Ampicillin, PLA2: Phospholipase A2, HDF: Hemodiafiltration.


(a) Shows cystic like hyperlucent area on the left posterior-basal segment of the lung (arrow).


(b) Thoracic computed tomography confirms cystic changes in the left lower lobe, the largest of them is located in the left lower lobe posterior basal segment.


Chronological trend of liver enzymes during the postoperative course.


Radiographs of a patient who presented with multiple foot abscesses, showing osteopenic bones without erosive changes.


CT of abdomen and pelvis without contrast, showing large right-sided retroperitoneal mass (10x11x16 cm) concerning for hematoma of varying age.


Brain MRI showing new areas representing subacute watershed infarctions with several punctate areas of acute infarction within the bilateral anterior cerebral artery/middle cerebral artery watershed territories.


The mNGS and bone marrow result detected in Case 1. (A) The genome coverage of the detected reads of Leishmania shedunii.


The mNGS and bone marrow result detected in Case 1. (B) The abundance of detected microbe and their reads numbers. A total of 5074 specific reads (98.87%) of Leishmania were detected in the blood sample.


The mNGS and bone marrow result detected in Case 1. (C) The examination of a bone marrow aspirate revealed amastigotes.


The dose of liposomal amphotericin B (L-AmB) and changes of temperature in Case 1. The initial dosage of L-AmB in the first patient was 10mg/day and the patient's temperature decreased as the dose of L-AmB was escalated. Dose escalation was performed as follows: 10 mg on day 1, 30 mg on day 2, 80 mg on day 3, and 120 mg on day 4. However, the appearance of hypotension on day 4 of the treatment protocol forced the dose reduction on day 5 (80 mg/d). There was mild renal impairment on day 6. Therefore, treatment was interrupted on days 6-11, and his renal function gradually recovered during treatment cessation. Treatment was restarted at a dose of 10 mg/kg from day 12, and the dose was gradually increased at a rate of 10 mg/(kg day). The dose was increased to 40 mg on day 15. Since the patient's renal function was still slightly abnormal at day 15, the dose of L-AmB was not increased, but maintained at 40 mg during the next 12 days (day 16-27). Finally, we stopped the medication until the accumulating dose reached 890 mg(12.6 mg/kg) on the day 27. Polymerase chain reaction of Leishmania in a bone marrow smear was negative on day 17.


Liposomal amphotericin B (L-AmB) administration protocol and temperature changes in Cases 2-4. TAD, total accumulated dosage. Normalization of body temperature. Negative PCR result for bone marrow aspirate. To avoid complications associated with adverse drug reactions, the dosing regimens of L-AmB in case 2-4 were similar to those used for case 1, starting with a low dose that was gradually increased until the maximum tolerated dose was reached. This dosage was used for maintenance therapy. The initial dose for case 2 was 5 mg (~0.1 mg/kg) on day 1. The dose was increased to 10 mg on day 2-3, and no complications occurred. Therefore, the patient received L-AmB in 10 mg dose increments up to a dose of 60 mg (~1.2 mg/kg) on day 8. This dosage (60mg) was used for maintenance therapy until the cumulative dose of L-AmB reached 765 mg (13.9 mg/kg) on day 17. Her body temperature returned to normal on day 4. Polymerase chain reaction (PCR) for Leishmania in bone marrow aspirate was negative on day 12, when the dose of L-AmB was 405 mg. The trapezoidal regimen of L-AmB in case 3 was initiated at a dose of 5 mg (~0.1 mg/kg). The dosage of L-AmB was increased by 5 mg every 2 days as tolerated from day 1 to day 8 and increased by 10 mg every 2 days from day 9 to day 13 to 50 mg (~1.0 mg/kg), which was administrated as maintenance therapy on days 14-22. Treatment was stopped when the cumulative dose of L-AmB reached 740 mg(14.8 mg/kg) on day 22 of protocol. The patient's body temperature had returned to normal on day 4. PCR for Leishmania in bone marrow aspirate was negative on day 15, when the cumulative dose of L-AmB was 400 mg. In case 4, L-AmB treatment was initiated at a dose of 10 mg and increased in increments of 10 mg (~0.14 mg/kg) daily, reaching 70 mg (~1.0mg/kg) on day 7 of the protocol. To avoid complications, instead of further increasing the L-AmB dose, we used a dose of 70 mg as maintenance therapy until the cumulative dose reached 910 mg (13 mg/kg) on day 16. His body temperature returned to normal on day 7. PCR for Leishmania in bone marrow aspirate was negative on day 9, when the cumulative dose of L-AmB was 420 mg.


The figure shows a TEE long axis view of the aortavalve and ascending aorta. The arrow denotes the vegetation on the bicuspid valve.


CT abdomen. Huge right suprarenal mass measuring 16.5 x 6.5 x 8.7 cm.


CT abdomen. Right adrenal mass with break down areas and calcifications.


Images showing no evidence of PTB pre-treatment ,. (A) Initial disease progression (2 Apr 2014).


While. Show development of PTB during administration of nivolumab. (B,C) PTB infection during nivolumab treatment (22 Apr 2016).


(D) shows a follow-up radiological investigation demonstrating cancer progression. (D) Progression of disease (9 May 2016).


Circinate lesions present over glans before treatment.


Lesions present on under surface of prepuce before treatment.


Various psoriasiform changes seen on histopathological examination.


Post-treatment complete resolution of lesions from glans.


Post-treatment complete resolution of lesions from under surface of prepuce.


Medical image.


Microcephaly. Gastric biopsy: EBV-encoded small ribonucleic acid (EBER1) in situ hybridization shows positive nuclei EBER+ in the T cells lymphocytes.


(D) Clinical evolution, EBV load and therapeutics.


Photographic images of vitiligo with isolated areas of pigmentation on the upper limbs.


Trunk.


Highlighted by dermatoscopic examination.


Reflectance confocal microscopy images of apparently normal skin with low pigmentation in the dermal layer.


Vitiligo lesions , showing disappearance of the normal ring structures at the dermo-epidermal junction level with only a shadow of the pre-existing dermal papillary rings and no bright structures detected in the upper epidermal layers.


X-ray (lateral view) images illustrating the cannula and probe positions during the CRFA procedure:. At C4 medial branch.


At C3 and C5 medial branches.


Gastric tissue sections from a patient with metastatic gastric cancer and rare severe immune-related cholestatic hepatitis and subsequent severe late-onset pneumonia after pembrolizumab therapy. Representative photomicrographs show H&E staining.


Gastric tissue sections from a patient with metastatic gastric cancer and rare severe immune-related cholestatic hepatitis and subsequent severe late-onset pneumonia after pembrolizumab therapy. Immunohistochemical staining with programmed death-ligand 1 (PD-L1) , using a PDL1 antibody (DACO, 22C3).


The timeline of diagnosis, treatment and related immune-side effects of this patient since diagnosis.


Reprensentative images of magnetic resonance cholangiopancreatography.


Abdominal computed tomography. In a patient with metastatic gastric cancer and rare severe immune-related cholestatic hepatitis and subsequent severe late-onset pneumonia after pembrolizumab therapy. No obvious biliary obstruction was observed.


Midesophageal long-axis view showing anterior mitral leaflet aneurysm and healed vegetation on the Aortic valve.


Midesophageal two-chamber view showing anterior mitral leaflet aneurysm that expands during systole with severe mitral regurgitation.


CT image. . Notes: (A) Infiltration of the right upper lobe of the lung before treatment.


CT image. (B) Infiltration of the right upper lobe of the lung after IL-2 therapy.


CT image. (C) Infiltration of the right upper lobe of lung worsened after PD-1 inhibition.


CT image. (D) Infiltration of the right upper lobe of lung absorbed after 6 weeks of anti-TB treatment. . Abbreviations: CT, computed tomography; TB, tuberculosis.


Histopathological findings of TB granuloma from the lung biopsy. . Notes: A large amount of caseous necrosis surrounded with epithelioid cells and diffused infiltrating lymphocytes (paraffin-embedded tissue by H&E staining). (A) Original magnification (20x). Local magnification of. (400x). Solar marking: caseous necrosis; blue arrows: epithelioid cells. . Abbreviation: TB, tuberculosis.


Histopathological findings of TB granuloma from the lung biopsy. . Notes: A large amount of caseous necrosis surrounded with epithelioid cells and diffused infiltrating lymphocytes (paraffin-embedded tissue by H&E staining).


Palmar injection site locations (representation only, not a patient photo).


Abdominal CT scan revealing marked air within the gastric wall (green arrows), extensive prominent looping of the small bowel (red arrows), and air within the portal vein (blue arrows).


Gross specimen of the stomach retrieved from autopsy showing areas of hyperemia and necrosis suggestive of emphysematous gastritis.


The X-ray shows bilateral and extensive interstitial infiltrates.


The violaceous rash extension with atypical targetoid elements (at day 3 from clinical onset) is depicted in a. b shows the complete resolution (after 6 weeks).


The extensive skin detachment is showed in a (at day 5) and its favorable evolution at 6 weeks in (b).


The figure shows the extensive disepithelialization with subcutaneous oozing and bleeding.


Proximal nailfold demonstrating several enlarged capillaries.


Telangiectasias along the marginal gingivae (arrow) and interdental papillae.


Alpaca (case no. 1), ear pinnae. Evolution of skin lesions from severe crusting dermatitis, hyperkeratosis, focal ulceration, alopecia, and scaling.


Alpaca (case no. 1), ear pinnae. To moderate to severe crusting, hyperkeratosis, scaling, erythema and alopecia.


Alpaca (case no. 1), ear pinnae. To mild to moderate alopecia, erythema and scaling.


Alpaca (case no. 1), ear pinnae. To mild alopecia and erythema.


Morphological features of Sarcoptes scabiei mites.


Llamas (case no. 2), skin lesions. Hind limb (after clipping): alopecia, moderate to severe erythema, severe scaling, and ,focal crusts.


Llamas (case no. 2), skin lesions. Hind limbs, perianal, peri vulvar region, and ,ventral aspect of the tail: alopecia, mild erythema, and ,scaling, and ,mild, focal lichenification.


Llamas (case no. 2), skin lesions. Ventral abdomen and axillae: extensive alopecia, moderate to severe erythema and focal hyperpigmentation.


ECG tracing in the emergency room. Sinus rhythm of 100 bpm, QT of 400 ms, and QTc of 516 ms.


ECG tracing before TdP. Sinus rhythm of 83 bpm, QT of 600 ms, and QTc of 707 ms.


The monitoring electrocardiogram shows that TdP is induced by the short-long cardiac cycles and is followed by an initiating PVC (A). The initiating PVC appears after the T-wave peak of the last beat before the onset of TdP. The red asterisk indicates atrial premature complexes not conducted to the ventricle.


However, if the atrial impulse propagates through the atrioventricular node and into the cardiac ventricles, it may induce TdP (B).


TdP strip (C).


ECG tracings at 4 h . (A) Sinus rhythm of 68 bpm, QT of 640 ms and QTc of 682 ms.


3 days. After successful effective cardio-pulmonary resuscitation and electric defibrillation. (B) Sinus rhythm of 54 bpm, QT of 680 ms and QTc of 643 ms.


Phylogenetic analysis. The red arrows indicate the sequences in this case: clone 1 A2, HBV/A2 (Fig. 1a). Clone 2 G/A2, HBV/G/A2 recombinant (Fig. 1b).


(A) Slit-lamp examination of the left eye demonstrates 2+ conjunctival injection with a central, feathery infiltrate and corneal edema. A 1 mm hypopyon is also present.


(B) Fluorescein staining confirmed the presence of an overlying epithelial defect.


(C) Lactophenol-cotton-blue stained microscopy reveals typical branched and densely clustered phialides.


(D) Violaceous-red-rose pigmented and velvety colonies grew on Sabouraud agar.


Histology of the surgical specimen. (A) Calcitonin-positive medullary thyroid cancer is adjacent to normal thyroid tissue (immunohistochemistry, x10).


Histology of the surgical specimen. (B) Solid nests of metastatic medullary thyroid cancer (arrows) in a lymph node (hematoxylin and eosin, x10).


(A) Transverse plane of cranial MRI in constructive interference in steady state (CISS) sequence showing left-sided abducens nerve hypoplasia. Both abducens nerves are indicated by a white arrow.


(B) Coronal plane of cranial MRI in native T1 sequence illustrating relative atrophy of the lateral rectus muscle (white arrow) in comparison to the contralateral right side.


(a) Diagrammatic representation of the bicanalicular retrograde intubation dacryocystorhinostomy technique.


(b) The direction of the silicon tube through the common internal opening into the canaliculi.


Capillary zone electrophoresis. A decrease of the alpha-1 globin peak is notable.


Transthoracic echocardiography in a parasternal long-axis view showing an aneurismal sac posterior to aorta (arrow).


Transesophageal echocardiography in a four-chamber view showing aneurismal sac with neck (arrow) communicating with the LVOT.


Transesophageal echocardiography in four chamber view showing aneurismal sac in MAIF with rupture (arrow) into LA with color Doppler showing a turbulent jet resulting in supra-annular MR.


Axial view of a computed tomography scan of the abdomen at presentation demonstrating one of the large intra-abdominal collections measuring 129x58 mm.


Gram-stain demonstrating small Gram-negative bacilli (red arrow) in the presence of polymorphonuclear cells (blue arrow) on high power field microscopy.