Brain MRI of a 3-year-old girl with anti-N-methyl-d-aspartate receptor encephalitis. T2-weighted (axial view) MRI showing tiny white-matter lesions over bilateral frontal lobes. . Abbreviation: MRI, magnetic resonance imaging.


Showing the egg of Hymenolepis diminuta containing six central hooklets (x100).


The fundus photo of the left eye in 2013, 6 months after the single intravitreal injection of ranibizumab, shows decreased vascularization of the hemangioma and mild fibrosis.


Two-weeks follow up after topical therapy with 20% KOH solution.


Resolution of the lesions at 4 weeks after therapy.


(a and b) Setup of the overhead transparent plastic barrier with powered suction technique.


(a-c) Demonstration of a patient and anesthesiologist using the overhead transparent plastic barrier with powered suction technique.


Tumour molecular profiling and treatment strategy. Sequential therapeutic strategy of ALK tyrosine kinase inhibitors (TKI) and chemotherapy over the course of time together with detected molecular findings in patient tissue and plasma. FISH, fluorescent in situ hybridisation; MAF, mutant allele frequency; NGS, next generation sequencing.


The treatment procedures and corresponding leukocyte counts in the patient's cerebrospinal fluid. Monocytes were predominant among CSF white cells; they had a proportion of approximately between 60 and 90%. The CSF protein level was also elevated to 95.00-125.20 mg/dl. mNGS. P, metagenomic next-generation sequencing of cerebrospinal fluid detected Sarocladium strictum positive; Culture. P, Sarocladium strictum was positive in cerebrospinal fluid culture.


Enhanced abdominal CT taken on day 14. Part of the intestine was dilated and there was gas and fluid accumulation, and the gas-liquid level was visible.


Clinical course of the patient.


(a) Single-photon emission computed tomography with low-dose screening computed tomography of the pelvic region showing increased tracer concentration in the articular margin erosions with adjoining sclerosis in bilateral sacroiliac joints.


(a) STIR coronal section of the pelvis showing bilateral sacroiliitis with peripherally enhancing collection around bilateral sacroiliac joints (Right > Left).


(b) T1-weighted magnetic resonance imaging image showing bilateral sacroiliitis with peripherally enhancing collection around bilateral sacroiliac joints (Right > Left).


T2 SPAIR axial section showing hyperintensity in the right iliopsoas muscle.


Treatment timeline for CRKP infection.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. Histograms compared Chao1 index.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. Shannon index. Of the fecal microbiome in the donor and the patient pre- and post-FMT.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. PCoA plots showed the microbial community variation of the donor and the patient pre- and post-FMT based on weighted UniFrac distance.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. And unweighted UniFrac distance FMT 1W, FMT 3W and FMT 2M represented 1 week, 3 weeks and 2 months after FMT.


Farewell reception by hospital staff at the Medical Center of Aurora to the COVID-19 survivor discharging to rehabilitation on hospital day 28.


Embolia cutis medicamentosa. A reticulate, nonblasnching, nonindurated, coalesced areas of mottled erythemato-violaceous patches over the right superior gluteal distribution with extension to the lateral aspect of the thigh, and right lumbar paraspinal area, with satellite lesions measuring in its maximum diameter 23 cm x 18 cm.


Magnetic resonance imaging.


Magnetic resonance imaging. T2-weighted sagittal spine magnetic resonance imaging revealed a longitudinally extensive altered signal intensity from T7 level to conus level with. (T2-weighted axial magnetic resonance imaging at T10 level) centromedullary cord involvement.


(A) Magnetic resonance brain images with fluid attenuated inversion recovery (FLAIR) sequences of October 2017, when patient presented with recurrent seizures. Images show distinct cerebral small vessel disease.


(B) Diffusion weighted imaging sequences of the same examination show point-shaped infarction in left-sided MCA-territory (white arrow).


(C) FLAIR sequence of April 2018 when patient deteriorated clinically with clear increase of white matter damage.


(D) FLAIR sequence of October 2018, when patient presented for fifth cycle of cyclophosphamide treatment and with a marked clinical improvement. Images show a clear reduction of small vessel disease.


Timeline of clinical and diagnostic events. Weeks since initial presentation (antecedent pneumonia) are presented as gray blocks of 1 week each (bottom row). Clinical events are presented (top row) with inpatient weeks in dark gray and outpatient weeks as light gray blocks. Diagnostic testing and corresponding results, as well as selection and duration of antibiotics are indicated.


The Goldman visual field test showed constriction of visual fields in both eyes.


Paratesticular tumour composed of interlacing fascicles of spindled smooth muscles (hematoxylin-eosin, objective 20x).


Different treatment periods of cranial MRI. (A-C) Multiple enhancing masses were shown in the corpus callosum and around the ventricles before our interventions.


Different treatment periods of cranial MRI. (D-F) Partial response after two cycles of treatment.


Different treatment periods of cranial MRI. (G-I) No obvious masses after finishing our treatment.


Different treatment periods of cranial MRI. (J-L) 30 months follow-up.


(A) Haematoxylin-eosin (H&E) staining of biopsy samples (40x magnification).


Immunohistochemical staining showed that tumor cells were positive for CD20.


But not for CD30.


Cyclin D1.


CT images after respiratory failure happened. Mediastinal emphysema was occurred after receiving invasive mechanical ventilation. Mediastinal window.


CT images after respiratory failure happened. Mediastinal emphysema was occurred after receiving invasive mechanical ventilation. And lung window.


A; Chart of the patient's medical procedures.


CSF parameters according to different antibiotic treatments and colistin MIC values. . Notes: CSF WBC (cells/muL) <img>; CSF glucose (mg/dL) <img>; Colistin MIC <img>. R: colistin breakpoint=4 (EUCAST). . Abbreviations: CSF, cerebrospinal fluid; EUCAST, European Committee on Antimicrobial Susceptibility Testing; EVD, external ventricular device; MIC, minimum inhibitory concentration; WBC, white blood cell.


Clinical features of dermatomyositis with shawl-like rash affecting neck, chest and back. A; Flagellate erythema upper back.


Clinical features of dermatomyositis with shawl-like rash affecting neck, chest and back. B; 'V' neck distribution of erythema.


The lung infiltration resolved in the chest X-ray following the treatment.


Infiltrated plaques on nose, left dorsum of wrist and on index finger of right hand.


Nodular lesions on dorsum of both hands.


(A) Sagittal T2-weighted magnetic resonance imaging scan revealing a well-defined high signal intensity mass, 3.1 cm in size, at the anterior aspect of the endocervix, along with multiple uterine myomas less than 9 cm in size.


(B) Macroscopically, the cervix was open at 12 o'clock.


(C) The cells had large, ill-defined cytoplasmic borders, abundant cytoplasm, prominent nucleoli, and syncytial growth patterns (H&E, x200).


(D) Formalin fixed paraffin-embedded tissue used for in situ hybridization for Epstein-Barr virus-encoded early RNAs. The result was negative.


CfDNA monitoring of EGFR ex19del and EGFR T790M mutations. Each dot corresponds to a different liquid biopsy time point. AF, allele frequency; CT, chemotherapy with platinum-etoposide.


Drug screening in a primary cell line following osimertinib resistance. Primary cells were treated with 250 nM osimertinib, 0.150 mug/ml etoposide, and 0.05 mug/ml cisplatin. After 72 h, cell proliferation was assessed by CellTiter 96. AQueous One Solution Cell Proliferation Assay (MTS). Data are expressed as percent of cell viability vs. control cells and are means +- SD of three measurements. *p < 0.05.


MRI Brain (T2 axial) of the patient done five months after onset of neurological symptoms revealing normal study.


Electroencephalograph of the child (Monopolar montage, Sensitivity of 20 microvolt/mm, Speed 30 sec/page) showing periodic slow wave complexes lasting for 1.5 to 2 seconds occurring at a regular interval of 18 seconds.


Transesophageal echocardiographic examination showing a large atrial septal defect. Arrowheads).


A large parachute-shaped mass attached to aortic valve. Right arrowheads), and . A large mass in the left atrial appendage. Left arrowheads, Video 1), suggestive of vegetation in a patient with intravenous drug abuse and Pseudomonas endocarditis.


Transesophageal echocardiographic examination demonstrating multiple vegetation attached to mitral valve leaflets. Arrowheads) with a large fluttering saccular mass (1.4 cm x 4 cm) in the left atrium attached to the posterior mitral valve leaflet bulging into the left atrium suggesting mitral valve aneurysm. Arrowheads, Video 1) in a patient with intravenous drug abuse and Pseudomonas endocarditis.


Arrowheads) with a large fluttering saccular mass (1.4 cm x 4 cm) in the left atrium attached to the posterior mitral valve leaflet bulging into the left atrium suggesting mitral valve aneurysm. Arrowheads, Video 1) in a patient with intravenous drug abuse and Pseudomonas endocarditis.


Transesophageal echocardiographic examination showing a large left atrial vegetation intermittently resembling a "cat" face with prominent eyes, nose, and mouth (Video 2) measuring 4.9 cm x 1.9 cm in a patient with intravenous drug abuse and Pseudomonas endocarditis.


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (a) Axial contrast-enhanced computed tomography scan of the abdomen through the level of the kidney showing mass-like low attenuation lesion (yellow star) in the interpolar region of the right kidney with moderate surrounding perinephric inflammatory changes (blue arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (b) Coronal reformat contrast-enhanced computed tomography scan of the abdomen and pelvis showing mass-like low attenuation lesion (yellow star) in the interpolar region of the right kidney with moderate surrounding perinephric inflammatory changes (blue arrow). There is also mild diffuse bladder wall thickening (red arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (a) Axial contrast-enhanced computed tomography of the abdomen through the level of the kidneys shows low attenuation lesions (yellow star) in the interpolar region of the right kidney with improving perinephric inflammatory changes 3 weeks later (blue arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (b) Coronal reformat contrast-enhanced computed tomography scan through the abdomen showing low attenuation lesions (yellow star) in the interpolar region of the right kidney with improving perinephric inflammatory changes 3 weeks later (blue arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical Bacillus Calmette-Guerin therapy. (a) Axial computed tomography of the abdomen through the level of the kidneys demonstrates a percutaneous computed tomography-guided biopsy of the lesion (blue circle).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical Bacillus Calmette-Guerin therapy. (b) Core needle biopsy from right renal mass showing marked chronic inflammation with granulomas (red circles). Special stains for acid-fast bacilli (Fite) and fungi (GMS) were negative (not shown).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (a) Axial contrast-enhanced computed tomography scan of the abdomen through the level of the kidneys showing interval resolution of the right renal lesions with mild residual cortical scarring 8 months later (blue arrow).


A 49-year-old male with a history of high-grade T1 urothelial cell carcinoma of the bladder undergoing induction bacillus Calmette-Guerin immunotherapy. Initial presentation with fevers and chills after 3 weeks (4 of 6 treatments) of intravesical bacillus Calmette-Guerin therapy. (b) Coronal reformat contrast-enhanced computed tomography scan showing interval resolution of the right renal lesions with mild residual cortical scarring 8 months later (blue arrow).


Contrast-enhanced computed tomography abdomen,. Coronal section showing. Multiple, tiny hypodense splenic lesions (thin arrow) with clustered pattern of distribution in subcapsular location and perisplenic extension (curved arrow).


Contrast-enhanced computed tomography abdomen,. Magnetic resonance imaging abdomen, axial section showing T2-weighted image.


Contrast-enhanced computed tomography abdomen,. Diffusion-weighted imaging. Showing multiple T2 hyperintense lesions with diffusion restriction in the spleen.


Previous treatment with corticosteroids. . Abbreviations: BM, betamethasone; FM, fluorometholone; PSL, prednisolone; HSK1, herpes simplex keratitis (geographic ulcer and stromal keratitis); TLO, trabeculotomy; TLE, trabeculectomy; HSK2, herpes simplex keratitis (stromal keratitis); PKP, penetrating keratoplasty; CI, corneal infiltration of unknown cause; FK, fungal keratitis.


Chest X-ray with left-sided pneumothorax and cervical subcutaneous emphysema.


(A) The patient's EEG after the first seizure in October 2020.


(B) The patient's EEG after the second seizure in October 2020. The pink box showed EEG becomes abnormal situation with sharp and slow waves.


Still picture of Supplementary Video S1 highlighting upper limb tremors and orofacial dyskinesias.


Axial magnetic resonance imaging (MRI) slice images of the brain: On admission:. T1-weighted contrast-enhanced (T1+C).


Axial fluid-attenuated inversion recovery (FLAIR) sequences illustrating contrast enhancement (white arrow) with sulcal hyper-intensity (black arrow) respectively.


Day 15:. T1+C.


FLAIR sequences illustrating resolution of MRI abnormalities.


The electroencephalography depicted a ss-rhythm, with an intermittently slow wave activity of 6-7/s. The independent component analyses showed a frontocentral topography (component 4, framed) compatible with tiredness.


Twenty-four hours of electrocardiogram showing signs of vegetative dysbalance with intermittent sinus tachycardia during daytime and sinus rhythm with stable frequencies during the night (presented are mean heart rates per minute). HF, heart rate; HFmax, maximum heart rate; HFmin, minimum heart rate.


Neuropsychological test results. t0 testing was performed before treatment, and t1 testing was performed 14 days after the steroid pulse treatment.


Colonies of
M. vaccae
 on a blood agar plate.


(A) Midsagittal MRI at age 3 showing no cerebellar changes at that time.


(B) Midsagittal MRI at age 11 showing evidence of asymmetric volume loss within the superior and middle components of the cerebellar vermis with preserved volume of the inferior component (red outline).


(C) Axial plane MRI exhibiting faint linear/T2 signal hypointensities within the Pons (red arrow).


Chromosomal microarray showing 1.422 megabase loss in the 13q12.12 region containing 14 different genes, including the SACS gene.


Chest radiographs of CMV pneumonia. (a) Initial chest radiograph with extensive right lung opacities, most prominent in the right middle lobe.


Chest radiographs of CMV pneumonia. (b) Chest radiograph on day 8 with an increase in right-sided infiltrates and new infiltrates at the left lung base.


Chest radiographs of CMV pneumonia. (c) Chest radiograph on day 22 with reduced infiltrates in the right lung field with a moderate overlying pleural effusion.


Transthoracic echocardiogram revealing a large pericardial effusion in the left parasternal long-axis.


Short-axis. View.


Chest CT images for case 2 showing a round-like mass shadow in the dorsal segment of the lower right lobe with a slight ground-glass opacity on the edge, a strip shadow in the local area of the left lower lobe, and an arc dense under the bilateral pleura on day 3 after symptom onset (A-D).


Chest CT images for case 5 showing bilateral scattered spots of shadows and consolidation in the upper right lobe on day 3 after symptom onset (A,B).


Time course depicting the clinical presentation of IgG4RD, laboratory results and treatment plans from 2009 to 2020. Chronic phase of the patient's disease: the upper part summarizes the specific features of clinical findings, biopsy, imaging, and immunological laboratory results; the lower part shows the therapy, specifying dose, duration, and dates for Rituximab infusions (deep red diamonds) and steroids (sky blue bars). Pulse treatment with methyl-prednisone (500mg i. v. ) is represented by the bottom scale blue bars and was usually followed by oral Prednisone (top scale blue bars); the dashed bar corresponds to the period when the patient did not adhere thoroughly to the prescribed therapy.


In the acute phase, the upper part shows the laboratory values for CFH (black, mug/ml), anti-CFH (pink, AU/ml), left y-axis, and thrombocytes (green, G/l) at the right y-axis. The normal reference values are shown with shades matching the colors of the different parameters. The lower part depicts the therapy including methylprednisolone/prednisone (sky blue bars, mg/d), plasma exchanges (deep blue arrows), and cyclophosphamide (purple triangles, 500 mg i. V. ). The time when TMA and COVID-19 were diagnosed are shown with symbols. AU, arbitrary units; BM, bone marrow; Covid-19; coronavirus disease 2019; CT, computed tomography; CTX, cyclophosphamide; HPF, high-power field; IgA, immunoglobulin A; IgG4-RD, immunoglobulin G4-related disease; i. V. , intra venous; PET-CT, positron emission tomography-computed tomography; PLEX, plasma exchange; RTX, Rituximab; SARS-CoV-2 severe acute respiratory syndrome coronavirus 2; TMA, thrombotic microangiopathy.


Identification of IgG4 anti-factor H autoantibodies: Plasma samples were analyzed for anti-factor H antibodies by a previously reported specific ELISA which was developed using Horse Radish peroxidase (HRP)-labeled secondary antibodies specific for human IgG, IgG4, and IgA, respectively. Data are shown as optic density at 490 nm (OD). (A) The patient's serum was tested in duplicates at different dilutions 1:100, 1:400, and 1:1,000 for both IgG (black bars) and IgG4 (grey bars). Controls included a normal human serum (NHS), a serum with known elevated anti-CFH IgG levels, and a serum with elevated IgG4 but no anti-CFH activity.


Light microscopy:. Glomeruli shows cellular crescents.


Glomeruli shows segmental necrotizing lesion.


EM: focal podocyte foot process effacement, no deposits, no tubuloreticular inclusions.


The chest CT showed nodules and patches in the upper lobe of the left lung on admission.


Enlarged lesions in the upper lobe of both lungs and bilateral pleural effusions were observed on the 13th day after admission.


Bilateral infiltrates, interstitial infiltrates, alveolar infiltrates and bilateral pleural effusion were observed on the 20th day after admission.


Yeast forms of Penicillium janthinellum in BAL washings stained with fluorescence. Original magnification X 400).


Gram stains. Original magnification X 1000).


Hexamine silver. Original magnification X 400).


Fungal morphology stained with medan lactate. Original magnification X 400).


Colony morphology in the obverse side was cultured in 28. C PDA medium for 5 days.


Colony morphology in the reverse side. Was cultured in 28. C PDA medium for 14 days.


(a) Skull CT in axial cut without contrast showing expansive frontal lesion with hyperdense margin with thinning of the frontal bone.


(b) Skull CT in axial cut with contrast showing contrast enhancement at the margin lesion.


Intraoperative picture.


CT axial cut postoperatively.


Transthoracic echocardiography preoperatively showing a giant biatrial mass with the size of 44.06 mm x 109.44 mm in the right atrium.


17.85 mm x 23.87 mm in the left atrium.


Color Doppler flow imaging showing severe mechanical hemodynamic obstacles in the right atrium primarily occupied by the giant tumor tissue.


Cardiac CT showing a biatrial mass with the atrial septum infiltrated.


Abdominal CT showing an angiomatous mass in the right posterior lobe of the liver (arrow) (transverse view).


Coronal.


Sagittal.


Plane; cardiac MRI showing a giant biatrial mass with tricuspid valve involved.


PET-CT showing a giant mass with increased glucose metabolism in the right atrium.


Intraoperative view of the tumor: right atrium was enlarged. With the tumor inside the chamber.


The right side of the tumor was visualized with the opening of the right atrium.


The biatrial mass together with the infiltrated septum was resected.


The biatrial mass together with the infiltrated septum was resected . The right atrial lesion was grossly composed of two parts. Arrows).


Immunohistochemistry post-operatively confirm the diagnosis of the cardiac myxoma with interstitial fibrous hyperplasia.


Hemorrhage , necrosis, and plasmacytes infiltrate.


Pedigree of the proband.


(a) Head CT scan showing diffuse and thick SAH on admission.


(b) 3D image of left IC angiography showing a paraclinoid aneurysm.


(c) The aneurysm was successfully obliterated with coiling.


(d) Head CT scan on day 3 showing most of the SAH was washed out.


Neuroimages obtained at the onset of deafness. (a) MR angiogram showing severe vasospasm in the right MCA and moderate vasospasm in the left MCA.


Neuroimages obtained at the onset of deafness. (b) DW image showing high signal intensity at the right insular cortex and the left superior temporal gyrus, indicating acute infarction due to vasospasm.


Neuroimages obtained at the onset of deafness. (c) ASL images show bilateral superior temporal gyri.


Clinical response to long-term immunotherapy and the effect of surgery. (A) Schematics showing the time line of patient's diagnosis, treatment and response.


Clinical response to long-term immunotherapy and the effect of surgery. (B) Computed tomography scans and Magnetic resonance imaging showing clinical response to immunotherapy and the effect of surgery.


Clinical response to long-term immunotherapy and the effect of surgery. (C) The result of PD-L1 staining before immunotherapy.


Clinical response to long-term immunotherapy and the effect of surgery. (D) PET-CT scan before Lung tumor resection. TC, paclitaxel+carboplatin; Pembro, pembrolizumab.


Examination of specific markers expression of ganglioneuroblastoma (case 1). A) Hematoxylin and eosin staining of the tumor sample (HE; 200x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). B) NB84 expression in the tumor (immunohistochemistry NB84; 400x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). C) Protein S100 immunoreactivity on the cells of the tumor (in this case ganglioneuroblastoma, S100; 400x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). D) CD56 also called neural cell adhesion molecule (NCAM) immunoreactivity on the ganglioneuroblastoma cells (CD56; 200x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). E) Positive expression of neuron specific enolase in the tumor sample (NSE) (NSE; 200x).


Examination of specific markers expression of ganglioneuroblastoma (case 1). F) PGP9.5 expression in the tumor sample (PGP9.5; 200x).


CT of the abdomen - heterogeneous tumor with calcifications (70 x 70 x 100 mm) localized in retroperitoneal left space near left kidney (case 2).


Scarring alopecia over scalp.


Non-scarring alopecia was present over the pubic region.


Multiple follicular-oriented papules over the abdomen and trunk.


Optical coherence tomography of the lesions of the right.


Left. Eye showing choroidal lesions causing elevation of the retinal pigment epithelium and subretinal fluid.


Pedigree and clinical phenotype of proband. (A) Pedigree, with affected individual (the proband) in black and unaffected individuals in white. PIK3R1 genotyping of the pedigree identified a de novo mutation in the proband; WT, wild type.


Pedigree and clinical phenotype of proband. (B) Peripheral vasculitis of digits and heel.


Pedigree and clinical phenotype of proband. (C) Facial gestalt reminiscent of SHORT syndrome (short stature, hyperextensibility of joints and/or inguinal herniae, ocular depression, rieger anomaly of the eye, and teething problems): ocular depression, nasal deviation, and prominent mandible present in the proband (see main text and Supplemental Table 1).


Pedigree and clinical phenotype of proband. (D) Sanger sequencing confirmed a heterozygous splice site G/A mutation (black/green overlapping line) at position c.1425 + 1 of PIK3R1 gene in family member II-2 only.


Pedigree and clinical phenotype of proband. This mutation is absent (single black line corresponding to wild type "G" allele) in the other family members 1,. . 2, II-1, and II-3).


The timeline from the episodes of care of both patients.


Chest radiography images. Before.


After nine months of isoniazid treatment for the patient who progressed to active disease following the latent tuberculosis infection treatment.


Funduscopic appearance at 15-month follow-up showed relatively good retinal condition.


Sagittal.


Axial MRI of the lumbosacral spine revealed L1-L2 spondylodiscitis/osteomyelitis with a small, noncompressive anterior epidural collection and bilateral psoas muscle abscesses.


(a) Sagittal CT reconstructions of the lumbosacral spine demonstrate an extensive lytic process involving the L1 and L2 vertebral bodies. There is a significant involvement and narrowing of the L1-L2 disc space with endplate erosion.


Medical image.


MRI of the lumbar spine confirms CT findings and suggests L1-L2 spondylodiscitis. In addition, there is a progression of a large enhancing anterior epidural collection, which is compressing the thecal sac at L1-L2 and bilateral psoas muscle abscesses are demonstrated.


Cranial magnetic resonance axial section in sequence Standardized T1 weighted 3D Turbo Field Echo (sT1W 3D TFE).


Elbow and wrist flexors in paretic left upper limb in patient before being treated with incobotulinumtoxinA.


Postoperative X-ray of the right hip 4 days after operation.


8 years later . The X-ray 8 years later (B) was done in an external clincic, so unfortunately the complete endosprosthesis is not illustrated. The metaphyseal part shows no loosing. The patient is content and has no symptoms or complaints. Therefore, a current x-ray imaging is unnecessary.


Axial computed tomography study of the brain. . Notes: Minute cortical and subcortical calcifications located in bilateral frontal lobe.


Spin-Echo T2-weighted sagittal projections on magnetic resonance imaging study of the brain. . Notes: A "cobblestone" appearance is evident in the bilateral frontal opercular region.


Electroencephalogram showing diffusely deregulated cerebral electrical activity together with ubiquitous fast paroxysms, prevalent in the left temporal area.


Performing ERCP on a 73-year-old female patient presented with acute pancreatitis secondary to JPDD related CBD stone. (A) CT scan shows the inflammation and swelling of the pancreas and a mildly enlarged gallbladder. A diverticular pouch was present at the junction of second and third portions of the duodenum (yellow arrows).


Performing ERCP on a 73-year-old female patient presented with acute pancreatitis secondary to JPDD related CBD stone. (B) MRCP coronal haste thin slice image confirmed shows the presence of periampullary diverticulum, which causes extrinsic compression upon the CBD (yellow arrow). Note the possible CBD stone associated with dilation of the distal end of CBD.


Performing ERCP on a 73-year-old female patient presented with acute pancreatitis secondary to JPDD related CBD stone. (C) ERCP confirm the CBD stone and divericulum exerting compression upon the CBD outlet.


Performing ERCP on a 73-year-old female patient presented with acute pancreatitis secondary to JPDD related CBD stone. (D) The stone was successfully removed though the ERCP procedure.


(A-C) HCWs adhere to Level 2 biosafety requirement during the procedure. ERCP Endoscopy personnel precautions and dress code as follows: prior to ERCP procedure, the patient's status of COVID-19 was verified among the ERCP team. HCW wore PPE in the following order: respirator (N95, NK95, or the equivalent); impermeable gown; a first pair of gloves (over the impermeable gown that cover the wrist); lead aprons, thyroid shields, and dosimeters; boot covers; goggles and face shield; disposable isolation gown; and a second pair of gloves (over the isolation gown which cover the wrist). Washing hands with soap and water or alcohol-based hand rub were mandatory before and after patient interaction, contact with potentially infectious sources, and before putting on and upon removal of PPE.


The VNS device and an intraoperative photograph of the left vagosympathetic trunk. The pulse generator (width 45 mm, height 32 mm, depth 6.9 mm, and weight 16 g) (A).


The VNS device and an intraoperative photograph of the left vagosympathetic trunk. The electrode (B).


The VNS device and an intraoperative photograph of the left vagosympathetic trunk. The left vagosympathetic trunk wrapped by the two helical electrodes and anchor tether (C). VNS, vagus nerve stimulation.


The number of FS-GTCS and FS-GTCS clusters per month (A).


The number of FS and FS clusters per month (B).


The number of seizure days (FS-GTCS and FS) per month (C). The asterisk indicates that VNS therapy was initiated in this month. Months -5 to 0 indicate the retrospective period; months 1 to 12 indicate the follow-up period. FS-GTCS, focal seizures evolving into generalized tonic-clonic seizures; VNS, vagus nerve stimulation.


Cardiac magnetic resonance imaging included cine MRI (left column), native T1 mapping (middle column), and late gadolinium enhancement (LGE) imaging (right column) and demonstrated several myocardial metastases on the two-chamber views (green arrows) and three metastases in the four-chamber views (cyan arrows). The metastases were best seen on T1 mapping and cine MRI and had long T1 and T2 (not shown) relative to myocardium.


MRI-scan two days after symptom onset. Emerging white matter lesions with slight restricted diffusion but without Gadolinium (Gd) enhancement. T1 Gd-enhanced.


MRI-scan two days after symptom onset. Emerging white matter lesions with slight restricted diffusion but without Gadolinium (Gd) enhancement. T2-FLAIR (fluid attenuated inversion recovery).


MRI-scan two days after symptom onset. Emerging white matter lesions with slight restricted diffusion but without Gadolinium (Gd) enhancement. DWI (diffusion-weighted imaging).


MRI-scan 10 days after symptom onset. Progressive widespread white matter lesions with restriction in diffusion but still unaffected blood-brain-barrier. T1 Gd-enhanced.


MRI-scan 10 days after symptom onset. Progressive widespread white matter lesions with restriction in diffusion but still unaffected blood-brain-barrier. T2-FLAIR.


MRI-scan 10 days after symptom onset. Progressive widespread white matter lesions with restriction in diffusion but still unaffected blood-brain-barrier. DWI.


MRI-scan at 1-year follow-up visit. Markedly reduced white matter lesions. Right occipital hyperintensity on T2 reflects brain biopsy area. T2.


MRI-scan at 1-year follow-up visit. Markedly reduced white matter lesions. Right occipital hyperintensity on T2 reflects brain biopsy area. T2-FLAIR.


MRI-scan at 1-year follow-up visit. Markedly reduced white matter lesions. Right occipital hyperintensity on T2 reflects brain biopsy area. DWI.


Anti-NMDA receptor antibodies in patient's cerebrospinal fluid and serum. Anti-NMDA receptor antibodies were positive in cerebrospinal fluid (IgG, 1:32) ,serum (IgG.


Anti-NMDA receptor antibodies in patient's cerebrospinal fluid and serum. 1:320). Before immunotherapy.


Anti-NMDA receptor antibodies in patient's cerebrospinal fluid and serum. 1:32). After 5 months of immunotherapy. . Abbreviation: NMDA, N-methyl-D-aspartate.


Marked mixed pulmonary pattern with diffuse radiographic lesions in a 7-month-old Miniature Poodle presented with respiratory decompensation while receiving appropriate antimicrobials. Right.


Marked mixed pulmonary pattern with diffuse radiographic lesions in a 7-month-old Miniature Poodle presented with respiratory decompensation while receiving appropriate antimicrobials. Left lateral radiographic projections showing bilateral diffuse lesions characterized by marked diffuse small airway thickening (white arrow), peribronchial cuffing and multifocal alveolar pattern (*) with air bronchograms (arrowheads). Incidentally, intra-thoracic tracheal luminal diameter (doubleheaded arrows) varied on average 28% between both lateral projections suggesting dynamic tracheal collapse. The tracheal bifurcation and principal bronchus were narrowed on the left lateral projection.


Marked mixed pulmonary pattern with diffuse radiographic lesions in a 7-month-old Miniature Poodle presented with respiratory decompensation while receiving appropriate antimicrobials. (C) On the ventrodorsal projection, the left cranial lung lobe is completely opacified (*) and the cardiac silhouette is shifted to the left (long horizontal arrow). The lesions are centered around the lobar and segmental bronchi (short arrows) and decrease in severity toward the periphery. The left caudal lung lobe (LCd; flared arrows) is the second most severely affected lobe after the left cranial lobe.


Transverse (3 mm-thick) computed tomographic (CT) images of a Miniature Poodle obtained at 9 months. Using a single slice CT).


8 years. Using a 64-detector row CT) of age displayed from the same level side by side. On the first study, the left cranial lung lobe (single opened arrow) is completely collapsed with almost complete absence of air in the airways. The caudal branch of the left cranial lobar bronchus is narrowed but filled with air (ventral to opened arrow on C). The left caudal lung lobe is also severely reduced in volume and thus, increased in attenuation with several air-filled end on airways (double arrows). The right lung is hyperinflated with the right cranial (RCr) and accessory (RAcc) lobes extending to the left of midline. Mosaic pattern characterized by a well circumscribed hypoattenuating area is seen in the accessory lobe (arrowhead). The parenchyma is otherwise relatively normal. By 8 years of age and after undergoing left cranial lobectomy as a puppy, the entire hyperinflated right lung has developed severe patchy parenchymal lesions consisting of ground-glass opacification (black arrows) and consolidation (*). This latter is most severe surrounding medium- to large-caliber dilated airways. Traction bronchiectasis (black arrowheads) in areas of architectural distortion is seen at the periphery of several of these airways, a common feature seen with pulmonary fibrosis. The mosaic pattern previously recognized in the accessory lobe (white arrowheads) is accentuated. Several cystic air-filled structures (white arrows) of varying size occupy the left caudal lobe.


Five years post left cranial lobectomy, radiographic lesions were still present especially in the left caudal lung lobe of a 6-year-old Miniature poodle. (A) Left lateral projection showing several areas of increased opacity in the cranioventral, caudoventral and caudodorsal lung field (arrows). In the caudodorsal lung field, a large bronchus (arrowhead) is dilated and does not taper as it extends toward the periphery indicating bronchiectasis. In the more severe opacified areas, small air bronchograms are seen (white arrow).


Five years post left cranial lobectomy, radiographic lesions were still present especially in the left caudal lung lobe of a 6-year-old Miniature poodle. (B) Right lateral projection revealing radiographic lesions (black and white arrows) similar to those on the left and most prominent in the caudodorsal lung field. They are less extensive in the ventral aspect of the thorax in comparison to the left lateral view. Note that some lesions maybe less distinct due to motion artifact.


Five years post left cranial lobectomy, radiographic lesions were still present especially in the left caudal lung lobe of a 6-year-old Miniature poodle. (C) As expected following left cranial lobectomy, leftward mediastinal shift remains visible (black arrow) on the ventrodorsal projection. The borders of the left caudal lobe appear retracted (arrowhead) and the lung lobe is increased in opacity. Lesions are most severe centrally and less extensive toward the periphery. Similarly, radiographic opacity is increased (white arrows) surrounding major lobar structures (vessels and bronchus) of the right lung and gradually diminish in periphery of the lung.


Chest computed tomography, showing perihilar consolidations at both sides with underlying bronchiectasis. In the periphery of the lungs smaller nodular infiltrates are visible. These are indicated by the arrows.


Microscopy after kinyoun staining of
M. microti
 in culture. This culture became positive after 75 days of incubation. The microscope used was a Zeiss Axioskop, the magnification x100.


Computed tomography of the left hip, showing bone destruction of the anterior side of the collum. Next to this site, multiple fluid collections are visible, which are highly suspicious for abscesses. These collections infiltrate in the adjacent muscles. The largest collection in this view measures 64.5 by 37.1 mm and has a very thick wall.


Pathological findings. Brain biopsy from the left frontal lobe. (A) Hematoxylin and eosin staining.


Pathological findings. Brain biopsy from the left frontal lobe. (B) CD20 immunohistochemical staining.


Pathological findings. Brain biopsy from the left frontal lobe. (C) Ki-67 immunohistochemical staining.


Pathological findings. Brain biopsy from the left frontal lobe. (D) CD3 immunohistochemical staining.


Contrast-enhanced brain MRI recorded 1 month after brain biopsy shows a spotty gadolinium enhancement in the left periventricular white matter (arrow) and post-biopsy scar (arrowhead).


With T2 hyperintensities.


(C) This lesion does not show abnormal hyperintensities on diffusion-weighted imaging (DWI).


Peripheral blood smear showing multiple areas of red blood cell agglutination (arrows).


Ultrasound and contrast-enhanced computed tomography (CT). (A) Ultrasound at first visit (Day 1): a 1-cm low echo cyst-like region in the right kidney (arrowhead).


Ultrasound and contrast-enhanced computed tomography (CT). (B) First contrast-enhanced CT (Day 36): the kidney is enlarged. Poorly enhanced masses with enhanced borders were found in both kidneys (arrowhead). Two to three patchy poorly contrasted areas were found in both kidneys, but it was difficult to identify if they were cysts or infectious lesions (arrow).


Magnetic resonance imaging (Day 60). (A) T2-weighted images: 2-mm high-signal small patchy shadows were found in both kidneys (arrow).


Magnetic resonance imaging (Day 60). (B) T2-weighted images: thick walls in the right kidney as low signals and mass as high signals were found in the interior (arrowhead). Diffusion-weighted images: masses as high-signal areas of thick-walled structures at the same site as. (arrowhead). Apparent diffusion coefficient (ADC) map: low-signal mass at the same site as. (arrowhead).


Magnetic resonance imaging (Day 60).


Magnetic resonance imaging (Day 428). (A) Diffusion-weighted images showed that the mass with high-signal areas of thick-walled structures disappeared (arrowhead).


Magnetic resonance imaging (Day 428). (B) Low-signal masses are also not visible on apparent diffusion coefficient (ADC) map (arrowhead).


Pruritic follicular papules over back.


(a) On dermoscopy the hairs were seen like loops.


(b) Solid papules over back seen on dermoscopy.


(a) Hairs coming out of the skin and again re-entering.


(b) Solid papules had bend hairs inside.


Coiled up strongyloides larvae.


Double bulb esophagus.


Primordial genital primordium.


Embryonated egg.


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. Biopsy of a cervical lymph node performed on day +36 showed effacement of the architecture due to numerous granulomas (low magnification.


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. , which were composed of epithelioid cells.


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. Between the granulomas a polymorphous lymphoid infiltrate was noted containing blasts as well as plasma cells (c).


Histological diagnosis of synchronous nodular tuberculosis and EBV-associated lymphoproliferative disorder. The blasts were latently EBV-infected as shown in the immunohistochemical demonstration of EBNA2 (d).


Radiological diagnosis of disseminated tuberculosis. CT scan of the thorax on day +43 after allogeneic stem cell transplantation revealed a borderline sized mediastinal lymph node with central necrosis.


Radiological diagnosis of disseminated tuberculosis. As well as multiple pulmonary nodules.


Histopathological examination of the papule (HE; x100).


Expression of CD63 on basophils in Patient 1, an atopic control, and a non-atopic control, after incubation with American and Korean ginseng.


CT showing infected aneurysm of the splenic artery (arrow) with complete distal obliteration.


The spleen showing multiple large purulent loculations (arrows).


Timeline of symptoms, diagnostic, interventions, and outcomes.


Shoot from brain MRI of May 8 in :. Show T2-FLAIR acquisition.


Shoot from brain MRI of May 8 in (C) Shows occipital lesion in T2-FLAIR acquisition.


Shoot from brain MRI of May 8 in (D) Shows parietal lesion in T2-FLAIR acquisition.


Shoot from brain MRI of May 8 in (E) Shows occipital lesion positive in DWI.


Shoot from Brain MRI of June 16: (F,G) show T2-FLAIR acquisition.


A; Chest CT on February 6, 2018 (before the administration of SOF/VEL), showed pleural effusion in the lower part of the right lung. The white arrows show pleural effusion.


B; Abdominal CT on February 6, 2018 (before the administration of SOF/VEL), showed ascites in the lower part of the liver. The white arrows show ascites.


A; Chest CT on September 25, 2019 (after the administration of SOF/VEL), showed that the pleural effusion in the lower part of the right lung had disappeared completely.


B; Abdominal CT on September 25, 2019 (after the administration of SOF/VEL), showed that the ascites in the lower part of the liver had disappeared completely.


Time course of serum ammonia level after SOF/VEL administration.


Time course of serum albumin level after SOF/VEL administration.


(A) Erythema and lots of tiny pustules on the abdomen.


(B) Many pustules on the basis of erythema on the lower abdomen.


(A) Lots of tiny pustules on the trunk.


(B) Many tiny pustules and some scales on the upper limbs.


Timeline of the case after admission. (A-C) Time course of CK, myoglobin, plasma creatinine, and levels of uPCR and uACR.


Timeline of the case after admission. (D) Time of treatment regimens and kidney biopsy. CK, creatinine kinase; CYC, cyclophosphamide; uACR, urinary albumin-to-creatinine ratio; uPCR, urinary protein-to-creatinine ratio.


Histopathological findings in a kidney biopsy confirming pauci-immune crescentic GN. Representative photomicrographs of the kidney biopsy including staining for IgA (scale bar: 50 mum), IgG (scale bar: 50 mum), IgM (scale bar: 50 mum), C1q (scale bar: 50 mum), and C3c (scale bar: 50 mum); periodic acid-Schiff staining showing a glomerulus with crescent formation (scale bar: 50 mum); and hematoxylin/eosin staining with myoglobin casts (asterisks, scale bar: 100 mum) and tubulointerstitial inflammation with prominent eosinophilic infiltration (scale bar: 100 mum). C1q, complement component 1q; C3c, complement factor 3 conversion product; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; GN, glomerulonephritis.


Concurrent CRRT, VA-ECMO and TPE. O2, oxygen, CO2, carbon dioxide, others as per Figure 1.


A-c Slit-lamp photographs on POD 5 (1 day after flap lift and irrigation). A; Right eye with improving peripheral keratolysis.


B; High magnification of peripheral keratolysis in the left eye.


C; Left eye with persistent peripheral keratolysis.


E Photographs at postoperative month 6, showing resolved keratitis with mild peripheral stromal scarring in the right eye. And left eye.


Electron microscopy of the renal biopsy showing subepithelial membranous deposits (arrow) and adjacent foot process effacement (description courtesy of John Higgins, MD, and Christina Kong, MD, Department of Pathology, Stanford University School of Medicine, Stanford, Calif. , USA).


Course of body temperature and clinical events. . Notes: Pyrexia was not seen on the day of admission. On postoperative day 2, body temperature suddenly rose. Thereafter, pyrexia was controlled with daily administrations of acetaminophen. Three days after discharge, severe pain in both shoulders and morning stiffness suddenly occurred. Body temperature was controlled by daily acetaminophen administration and remained normal after switching to prednisolone. . Abbreviation: P, prednisolone; URTI, upper respiratory tract infection.


Head computed tomography images of a 64-year-old man with asymptomatic symptom for coronavirus disease 2019. (a) Axial showing subarachnoid space dilated associated with cortical atrophy (Red arrows).


Head computed tomography images of a 64-year-old man with asymptomatic symptom for coronavirus disease 2019. (b) Choroid plexus calcification in the lateral ventricles (Red arrows).


Chest computed tomography (CT) images of a 64-year- old man with asymptomatic symptom for coronavirus disease 2019. Axial plane chest CT scans showing lymph nodes larger than 1 cm (Red arrows).


Erythematous and maculopapular rashes on the upper and lower extremities.


Sagittal T1-weighted magnetic resonance imaging (MRI) of the brain with gadolinium contrast. A) Preoperative image demonstrates a 2.6 x 1.6 cm enhancing mass with surrounding edema.


Sagittal T1-weighted magnetic resonance imaging (MRI) of the brain with gadolinium contrast. B) Axial diffusion-weighted MRI demonstrating perilesional edema but no solid areas of restricted diffusion to suggest abscess.


Sagittal T1-weighted magnetic resonance imaging (MRI) of the brain with gadolinium contrast. C) Postoperative image one day after surgery demonstrating gross total resection.


Sagittal T1-weighted magnetic resonance imaging (MRI) of the brain with gadolinium contrast. D) Postoperative image four months after surgery showing no recurrence.


Intraoperative images of tumor. Superficial mass with well defined margins and surrounding normal brain tissue.


Intraoperative images of tumor. Resection cavity.


Pathological examination of tumor. A) Hematoxylin and eosin staining show necrotizing granulomas with peripheral palisading epithelioid histiocytes, giant cells.


Pathological examination of tumor. B) Acid fast bacillus.


Chest computed tomography on admission of an asymptomatic 64-year-old woman infected with severe acute respiratory syndrome coronavirus-2. Ground-glass opacities were observed in the peripheral areas under the pleura on the right lower lobe (posterior basal).


Photographs of the anterior eye of the patients before and after treatment. A, b Case 1. A; A brown pigmented infiltrate in the paracentral cornea with few satellite lesions in the superior peripheral cornea 1 week after cataract surgery.


Photographs of the anterior eye of the patients before and after treatment. B; The corneal ulcers developed into scars after the treatment.


Photographs of the anterior eye of the patients before and after treatment. C, d Case 2. C; A corneal infiltrate with central brownish pigments on top of the lesion at presentation.


Photographs of the anterior eye of the patients before and after treatment. D; Scar tissue and vascularization replaced the corneal ulcer, with small foci of epithelial defects remaining after 1 month of treatment.


A; Potassium hydroxide preparation showing numerous dark septate fungal hyphae. Magnifications: x400.


B; Numerous fungal elements detected on calcofluor white staining. Magnifications: x400.


C; Microscopic analysis of b showing fungal hyphae and conidia. X100.


D; Dark pigmented colonies of F. Pedrosoi growing on Sabouraud's dextrose agar.


Results of Sanger sequencing of BLM of the proband. The red arrows indicate the c.1544delA (p. Asn515Metfs*16) (A) and c.692T>G (p.


Results of Sanger sequencing of BLM of the proband. The red arrows indicate the c.1544delA (p. Leu231*) (B) heterozygous variants.


Family pedigree. Filled black symbols represent individuals with diabetes. The red arrow indicates the proband.


Parotid fistula and Frey's syndrome.


The parotid region is divided into four quadrants. The injection points are at 1 cm from each other.


Intra-operative condition of the lesion located at middle of upper clivus region. The lesion was very tough, and ,firm (the arrow).


Intra-operative condition of the lesion located at middle of upper clivus region. The lesion was stick to the brain stem and basal artery (1: brain stem; 2: basal artery; 3: abducent nerve).


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Hematoxylin, and . Eosin (H&E) stain showed the lesion was composed of sclerosing fibrosis associated with dense lymphoplasmacytic infiltration. X40.


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Hematoxylin, and . . X100).


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Immunohistochemical analysis revealed over 400 IgG4-positive cells per high-powered field, and . A high IgG4/IgG ratio. IgG, x200.


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Immunohistochemical analysis revealed over 400 IgG4-positive cells per high-powered field, and . . IgG4, x200).


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. Immunohistochemical staining of CD38. Immunohistochemical staining of Ki-67.


Histological features of the lesion revealed an IgG4-related inflammatory pseudotumor. (F) Immunohistochemical staining of Ki-67.


Chest radiography revealed consolidation in the right lower lung field at the initial visit.


Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


X-ray pelvis showing reduced joint space with destruction of ischial tuberosity, acetabulum, and femoral head (arrowhead).


Hematoxylin and eosin staining (x10 objective): intense inflammatory response and giant cell reaction against lamellated membranes (arrowhead).


Hematoxylin and eosin staining (x40 objectives): Giant cell reaction against lamellated membranes (arrowhead).


Magnetic resonance imaging of the patient's brain. . Notes: (A) A T2-weighted image showing hyperintensity lesions (arrows) in the temporal lobes and left occipital lobe.


Magnetic resonance imaging of the patient's brain. (B) Multiple hyperintensities (arrows) in the temporal and parietal lobes and demyelination in the white matter surrounding the lateral ventricles revealed by the fluid-attenuated inversion recovery sequences.


Magnetic resonance imaging of the patient's brain. (C) A susceptibility-weighted image showing a low signal (arrow) in the right frontal lobe.


The electroencephalogram of the patient showing slow-waves characterized by strong peaks of delta (delta) and theta (theta) frequencies in the right frontal lobe. . Note: The arrows point to slow-waves from the Fp2-C4 and Fp2-L4.


Multiplex PCR. The present strain harbored iutA, rmpA, entB, and mrkD genes.


The patient developed ptosis, opthalmoplegia, chemosis, pupillary dilatation, and loss of sensation over the left eyelid in the immediate postoperative period.


Three months after the surgery, there was partial recovery of ptosis and opthalmoplegia.


Abduction of the left eye has not recovered in three months.


Three months after the surgery, chemosis is still present while opthalmoplegia has partially recovered.


Brain computed tomography scan of case 2. (A) The CT images show blocking of the right lateral ventricle but with obvious enlargement of the left lateral ventricle and the fourth ventricle, which indicate separation of the ventricular system.


Brain computed tomography scan of case 2. (B) Red arrow show the drainage tube.


RE. Macula with cotton wool spots, and ,minor microangiopathy signs temporal from the fovea.


FFA temporal periphery highlighting an area of ischemia bordered by neovascularisation.


FFA superior with microangiopathy.


Plain CT.


Contrast-enhanced scan. Of the kidney. The arrow shows a mass of 5.5 x 5.0 x 4.0 cm on the left side.


A pathological study of the mass on the left kidney confirmed it as renal cell carcinoma, clear cell type. (A) Low magnification.


A pathological study of the mass on the left kidney confirmed it as renal cell carcinoma, clear cell type. (B) High magnification. The cells have a clear cytoplasm, surrounded by a distinct cell membrane, and contain round and uniform nuclei.


Image of subconjunctival hemorrhage.


Toraks ct of first hospitalization day.


Toraks ct of third hospitalization day.


2D echo PLAX view showing subaortic membrane with marked left ventricular hypertrophy, and ,mild pericardial effusion.


2D echo PLAX view showing vegetation on anterior mitral leaflet, measuring 10 x 6 mm.


MRI brain axial section showing hypointense signal intensity alteration on T1WI.


Hyperintense on T2 FLAIR. In left parietal region, suggestive of acute infarct. There is also perilesional edema.


Changes of rectal ulcer on colonoscopy before.


After. Antiviral treatment.


The Genotype Mycobacterium CM (HAIN Lifescience) hybridization pattern for isolates from blood and pus samples (strip 3 and 4 from the top) with template (strip 1) for evaluation. Band 1 (CC): conjugate control; band 2 (UC): universal control; band 3 (GC): genus control; bands 5, 6, and 10: probes specific for M. abscessus.


FA of the patient's right eye taken over a 2-year period. . Notes: (A and B) Initial visit (early phase of FA of the right eye reveals a small irregular hyperfluorescence area inferonasal to the fovea with late-phase leakage that corresponds to the juxtamacular CNV lesion; arrows).


FA of the patient's right eye taken over a 2-year period. (C and D) One week after cessation of steroid therapy (a fulminant recurrence and development of CNV membrane with involvement of the fovea; arrows).


FA of the patient's right eye taken over a 2-year period. (E and F) Three months after PDT (progressive enlargement of CNV membrane).


FA of the patient's right eye taken over a 2-year period. (G) Recurrent activity of CNV membrane 8 months after the second intravitreal ranibizumab injection (circle).


FA of the patient's right eye taken over a 2-year period. (H) Two months after periocular triamcinolone injection combined with intravitreal ranibizumab injection (almost complete regression of active CNV membrane). . Abbreviations: CNV, choroidal neovascular membrane; FA, fluorescein angiography; PDT, photodynamic therapy.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (a) Lesions growing on the elderly patient's scalp resembled pustular erosions with eschars.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (b) Assuming an infectious origin, some lesions were detached successfully (indicated by an arrow) by using a gauze soaked with a 1 % NCT solution. Tissue and swabs were collected and sent for microbial culture.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (c) On day 3, treatment with 1 % NCT showed visible but slow regression of the lesions. Combination therapy with 1 % NCT and 1 % NBrT was commenced.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (d) The next day (day 4), the 1 % NCT and 1 % NBrT combination treatment had accelerated the regression and softening of the lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (e) By the fifth day of treatment, lesions together with a subcutaneous portion of skin could be partly removed without serious bleeding. Application of 0.1 % BAT twice daily was commenced at home.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (f) Evident accelerated tissue repair and almost total clearance of remaining lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (g) Wounds were epithelialized, with no evident recurrence of lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (h) Further epithelialization of the wounds from the previous lesions.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (i) Remarkable epithelialization and tissue repair induced the decision to end the treatments at the clinic.


Treatment of the chronic multi-bacterial infection of the scalp over 60 days with a combination of 1 % NCT, 1 % NBrT and 0.1 % BAT. (j) The skin was completely epithelialized and returned to normal pigmentation. Application of 0.1 % BAT was stopped.


CT Scan without contrast of the left lower extremity indicating the mass (red arrow).


MRI without contrast of the hip showing the fluid collection around left hip joint (red arrow).