Histopathological image showing presence of mucous cells containing mucin (Periodic acid-Schiff stain, x200).


Clinical aspect showing a normal colored volumetric tissue increase with fibrous consistence and smooth surface of approximately 30 mm of diameter located on the right side of the hard palate.


Computed tomography, in different cuts, showing a hypodense area in the right side of the hard palate (arrows). Pneumatization of the maxillary bone can be seen as a large radiolucency on the left side of the maxilla.


Histological aspect showing a parakeratinized stratified squamous epithelium, lamina propria formed by fibrous connective tissue and proliferation of mature adipose cells in the submucosa.


Clinical aspect of the hard palate after forty three months of follow up showing complete healing end no sign of recurrence of the lesion.


Trocar placement, two 10 mm (medial and central) and one 5 mm (lateral).


Frontal view of the patient showing mandibular swelling.


Intraoral view showing missing lower canines.


Orthopantomograph showing multiple cysts in maxilla and mandible.


Lower occlusal view showing radiolucency and impacted teeth.


Lateral skull view showing bridging of the sella turcica.


CT, axial view showing multiple cystic lesions in maxilla.


CT, axial view showing extensive cystic lesion in mandible.


Bifid third rib on the right side with dextrocardia.


CT, axial view showing calcification of falx cerebri.


CT, axial view showing calcification of tentorial cerebelli.


CT, axial view showing bifid spine, cervical and thoracic vertebrae.


Ultrasonographic image showing spleen in right hypochondrium.


Ultrasonographic image showing left hypochondrium.


Ultrasonographic image showing transposition of great vessels.


Multiple palmer pits.


Axial PET-IMG/CT shows hypermetabolic activity with standard uptake of 3.8 to 4.1 in left biceps femoris.


A coronal PET-IMG/CT demonstrating significant enlargement of soft tissue and fatty components in the biceps femoris muscle belly. Multiple serpiginous vessels are seen coursing through the soft tissue and surrounding edema.


T1-weighted axial MR image with fat saturation shows an encapsulated soft tissue mass with in the left biceps femoris muscle.


A; T2- weighted axial MR image showing avid enhancement of soft tissue components throughout the region indicating presence of various mesenchymal components including fat. Multiple serpiginous enlarged draining and feeding vessels can also be identified.


Light microscopy 4X showing malignant cells with clear cytoplasm invading into surrounding soft tissue and skeletal muscle.


Light microscopy 40X showing malignant cells with clear cytoplasm along with distinct cell membranes and prominent nucleoli. It was positive for cytokeratin, RCC, p-NRA and negative for CK7, CK20, S-100, MART-1, and PAS.


Computed tomography showing a retrobulbar orbital mass in the left orbit (black arrow).


Clinical image of the patient presenting with a mass on left nasal dorsum.


(a) A hypercellular cartilaginous area with early ossification and features of remodeling with polygonal and spindleshaped fibroblasts surrounding the osteochondromatous area (H&E stain, x100).


(b) Cartilaginous area with early ossification and features of remodeling with polygonal and spindle-shaped fibroblasts (H&E stain, x400).


Abdominal Computed Tomography scan image of the patient with HPRC: The abdomen CT scan with contrast of the patient showing a well defined homogeneous hypodense mass of 1.3x1.9 cm in the right kidney.


H&E histological slide of the patient's papillary renal cell carcinoma, Fuhrman grade III: Low powered magnification (50X) showing characteristic papillary architecture. Non neoplasticrenal parenchyma is seen on left (A).


H&E histological slide of the patient's papillary renal cell carcinoma, Fuhrman grade III: Low powered magnification (50X) showing characteristic papillary architecture. Occasional papillary structures demonstrate typical foamy histiocytes in fibrovascular cores upper left portion (100X) (B).


H&E histological slide of the patient's papillary renal cell carcinoma, Fuhrman grade III: Low powered magnification (50X) showing characteristic papillary architecture. High power magnification showing neoplastic papillary structures lined by eosinophilic cuboidal epithelial cells with ovoid nuclei and conspicuous nucleoli (400X) (C).


CT of neck demonstrating bilateral diffuse lymphadenopathy with the largest lymph node measuring 2.4 cm (arrow).


CT of neck demonstrating prominent maxillary gingival and palatal swelling and ulcerations with significant loss of maxillary teeth on the left side.


Hematoxylin and eosin (H&E) stain of left palatal ulcer demonstrating a heterogeneous admixture of large atypical lymphocytes with occasional Hodgkin Reed-Sternberg (HRS) morphology, small lymphocytes, and histiocytes. HRS cells express CD30, PAX5, and EBER1 consistent with EBV-infected B-lymphocytes.


Post-radiation treatment response with resolution of the ulcers along right inner gingiva and left palate. Facial swelling has also resolved.


(a) Cyanosis on the left hand and skin ulcer on the fourth finger.


(b) Subtle livedo reticularis in fingers dorsum, without cuticle involvement.


(c) Intense livedo reticularis lesions in right palm, together with cyanosis in distal phalange.


(d) Erythematous-violaceous papules over left knuckles, one of them also hyperqueratotic due to a previous ulcer.


(a) Violet erythema in both eyelids, without involvement of nasal dorsum.


(b) Erythematous plaque on the right elbow with central desquamative and hyperkeratotic area from a previous ulcer.


(c) Right dorsum foot with erythematous warm and tender nodule.


(a) Superficial perivascular infiltrated of lymphocytes, with epidermal atrophy and dilated papular vessels with prominent endothelial cells (biopsy from the right-hand dorsum). Hematoxylin and eosin stain, original magnification:. X10.


(b) Dense, mostly septal, neutrophilic infiltrate with necrosis of fat lobules and calcium deposition, without dermal or epidermal involvement (biopsy from the right foot). X2.


Postoperative images. Axial postcontrast T1WI (a and b) showing subtotal removal of the intraventricular mass lesions.


Computed tomography scan of the abdomen/pelvis showing cecal mass.


Enlarged prostate The scan shows a prostatic space-occupying lesion with unclear rectal boundaries and an absence of the bladder seminal vesicle angle.


A; Primary tumor: coronal post-contrast image with left scalp mass confined to the soft tissues.


B; Recurrent tumor: coronal post-contrast image demonstrating a new nonhomogeneous mass in the left preauricular/parotid area, adjacent and inferior to the previous lesion site. Left level IV cervical lymph node is present (thin arrow). Left jugular vein displacement (thick arrow).


Radiograph-OPG.


Coronal Cut of Neck CT with contrast.


Representative sections of the tumor showing infarcted white parts, surgical margin inked green.


A: Tumor with a background of hemorrhage, inflammation, and a focus of normal salivary glands (asterisk) (H&E magnification x 40).


B: infarcted part of the tumor (asterisk) with abundant squamous metaplasia and keratinization (arrow heads) (H&E magnification x 100).


Bilateral choroidal metastasis seen as a pale patch like appearance on fundoscopy overlying the macula on the right.


Temporal to the equator on the left.


(c) Positron emission tomography-computed tomography showing high-grade neoplasm in the right upper lobe lung with mediastenal lymphadenopathy.


(d) Ninety-five percent isodose covering the bilateral orbits delivered by bilateral 15-degree wedged portals.


Follow-up contrast-enhanced T1-weighted axial cross- sectional magnetic resonance imaging (November 2017) showing a 10-mm left-sided frontal lesion within the anterior limits of the falx cerebri: Suspected metastatic lesion (pituitary carcinoma).


Blackening of skin of all the toes on both feet with swelling suggesting venous gangrene.


CT scan thorax showing left sided massive pleural effusion with atelectasis of left lung.


(b) Bronchial biopsy showing nuclear hyperchromasia with pleomorphism and keratinisation pearl (yellow arrow) suggestive of squamous cell carcinoma of lung (H and E, x200).


Axial MRI (a) of the brain demonstrates an enhancing lesion in the sella turcica and suprasellar space with extension to the left side of the sella and along the tentorium.


Coronal.


Sagittal. Gd-enhanced T1-weighted images demonstrate the lesion extending into the suprasellar space abutting the optic chiasm. The mass extends into the cavernous sinuses bilaterally with encasement of the bilateral cavernous carotid arteries. It also extends inferiorly on the left side into Meckel's cave.


Photomicrographs of tumor sections with H&E staining a; Monotonous lymphoid cells, which have irregular hyperchromatic nuclei with irregular nuclear contours, displace nests of pituitary cells.


Immunohistochemical staining with CD20 b; The tumor cells stained positive for immunohistochemical staining with CD20, demonstrating that they are a clonal proliferation of B cells.


Follow-up axial and coronal MR imaging at 3 months.


6 months. Post-surgery, chemotherapy, and radiation therapy demonstrate decreased size of the sellar mass, suggesting response to the treatment regimen.


Contrast enhanced CT Scan of thorax-showing mass lesion in the apical segment of right lower lobe.


Intraoperative specimen of Tumour Excision with wide local excision of the tumour done.


Hematoxylin and eosin staining of a tumor section (x200). Pathological light microscopic results.


Hematoxylin and eosin staining of a tumor section (x200). , well-differentiated to moderately differentiated adenocarcinoma seen in the upper lobe and pleura of the left lung.


Axial craniocerebral MRI. . Notes: (A) Before treatment, bilateral cerebellar sulcus line-like enhancement (black arrows) was seen.


Axial craniocerebral MRI. (B) After treatment, line-like enhancement had disappeared.


Axial craniocerebral MRI. . Notes: (A) Before treatment, line-like enhancement was seen in the right frontal lobe of the brain (black arrows).


Axial craniocerebral MRI. (B) After treatment, the line-like enhancement had disappeared.


Sagittal craniocerebral MRI. . Notes: (A) Before treatment, right lobe brain sulci visible line-like enhancement was seen (black arrow).


Sagittal craniocerebral MRI. (B) After treatment, the line-like enhancement had disappeared.


CT of the lung. . Notes: (A) Before treatment, small nodules were seen in the lower right lung.


CT of the lung. (B) After treatment, the small nodules had disappeared. . Abbreviation: CT, computed tomography.


Photomicrograph showing small-cell neuroendocrine carcinoma of cervix. (1a) H& E 10X and (1b) H&E 40X.


MRI pelvis showing well-defined iso-hyperintense lesion in the cervix (2.8 x 2.4 cm) and a large simple right ovarian cyst hypointense on T1Wand hyperintense on T2W.


Type III radical hysterectomy and BSO showing right ovarian simple cyst (15 x 8cm); cervical tumour 3.5 x 3.5 cm, mainly involving the endocervix; and posterior vaginal flap tumour nodule.


The anteroposterior pelvis graphy, determined multilobular dense nodular components in the periarticular soft tissue around the pelvis joint.


Radiographs of the right knee reveal calcified masses with lucent areas in the popliteal cavity of the knee joint.


(A) Abdominal computed tomography (CT) taken at 15 months after second-stage hepatectomy showed no recurrent lesion.


(B) Magnetic resonance image taken at 18 months after second-stage hepatectomy. Single recurrent mass (arrow) developed in remaining liver.


(C) Abdominal CT checked after radiofrequency ablation (arrow, post-radiofrequency ablation lesion).


(D) Abdominal CT taken at 14 months after radiofrequency ablation showed no other recurrent lesion (arrow, post-radiofrequency ablation lesion).


Abdominal computed tomography and magnetic resonance image taken at 36 months after second-stage hepatectomy (arrows, multiple recurrent lesions).


Surgical specimen and histopathological findings. (a) Only the scar tissue was shown at the lower ureteral site.


Surgical specimen and histopathological findings. (b) Accumulation of foamy histiocytes and infiltration of chronic inflammatory cells were observed around the necrotic tissue.


Multiplex fluorescence immunohistochemistry. Evaluation of immune cells before and after neoadjuvant therapy for upper urinary tract urothelial carcinoma. Representative multiplex fluorescence images of tumor-infiltrating T and B cells in the. Biopsy specimen.


Multiplex fluorescence immunohistochemistry. Evaluation of immune cells before and after neoadjuvant therapy for upper urinary tract urothelial carcinoma. Resected specimen. Nuclei, CD3, CD4, CD8, CD20, Ki67, and cytokeratin within the cells are shown in gray, blue, yellow, red, green, pink, and orange, respectively.


Multiplex fluorescence immunohistochemistry. Evaluation of immune cells before and after neoadjuvant therapy for upper urinary tract urothelial carcinoma. (C) Ki67high subpopulation of CD8 T cells (yellow arrows) was determined by visualizing nuclear Ki67 (pink) expression.


Multiplex fluorescence immunohistochemistry. Evaluation of immune cells before and after neoadjuvant therapy for upper urinary tract urothelial carcinoma. (D) Evaluation of each immune cell's density before and after pembrolizumab therapy in the biopsy and resected specimens.


Immunohistochemical staining demonstrating. Significant programmed death ligand-1 (PD-L1) expression.


Lack of PD-L2 expession in the biopsy specimen.


MRI of the face with contrast medium revealed the presence of an 8.3 x 4.8-cm heterogeneous mass lesion involving both nasal airways with obstruction and destruction of the nasal septum. There is extension into the underlying hard palate and into the left ethmoid, sphenoid, left maxillary sinuses, soft palate and uvula.


Sections demonstrate a dense, diffuse, pandermal proliferation of atypical lymphoid cells with eosinophilic cytoplasm, hyperchromatic nuclei, irregular nuclear membranes and inconspicuous nucleoli. Extensive apoptosis, prominent angiocentricity, focal epidermotropism and dermal necrosis are noted. The tumor cells were strongly immunoreactive for TIA-1, granzyme, CD8, CD2, CD56 and cytoplasmic CD3. A few cells were immunoreactive for CD5 and CD4. EBER in situ hybridization was positive in the majority of the neoplastic cells. The cells were negative for CD57. The findings are consistent with ENKL of the nasal type.


A 3 x 3-cm, erythematous, violaceous, well-circumscribed nodular lesion on the left thigh.


A 41-year-old pregnant woman in the 7th month of pregnancy referred for right-sided abdominal pain and the sonographic diagnosis of polyhydramnios and diagnosed with renal epithelioid angiomyolipoma associated with pulmonary lymphangioleiomyomatosis. (a) Transverse T2-weighted image depicts right renal heterogeneous mass lesion with slightly hyperintense parts (arrowhead), corresponding to areas of fat and solid components (asterisk), of low-signal intensity when compared to normal renal parenchyma.


A 41-year-old pregnant woman in the 7th month of pregnancy referred for right-sided abdominal pain and the sonographic diagnosis of polyhydramnios and diagnosed with renal epithelioid angiomyolipoma associated with pulmonary lymphangioleiomyomatosis. (b) Transverse T1-weighted image shows lesion heterogeneity, with areas of fat detected hyperintense (arrowhead) and solid parts (asterisk), isointense to normal renal medulla.


A 41-year-old pregnant woman in the 7th month of pregnancy referred for right-sided abdominal pain and the sonographic diagnosis of polyhydramnios and diagnosed with renal epithelioid angiomyolipoma associated with pulmonary lymphangioleiomyomatosis. (c) Transverse fat-suppressed T1-weighted image demonstrates saturation of the hyperintense T1 components (arrowhead) of the lesion, findings compatible with the presence of fat.


A 41-year-old pregnant woman in the 7th month of pregnancy referred for right-sided abdominal pain and the sonographic diagnosis of polyhydramnios and diagnosed with renal epithelioid angiomyolipoma associated with pulmonary lymphangioleiomyomatosis. (d) Transverse apparent diffusion coefficient map derived from source image with b value of 700 s/mm2 shows areas of restricted diffusion (asterisk) within the lesion. The apparent diffusion coefficient values were 0.92 x 10-3 mm2 s-1, lower than that of the normal contralateral kidney (2.30 x 10-3 mm2 s-1).


A 41-year-old pregnant woman diagnosed with renal epithelioid angiomyolipoma associated with pulmonary lymphangioleiomyomatosis. (a) Sagittal sonographic image of the right hypochondrium depicts the presence of a heterogeneous, ill-defined mass (cursors) in the interpolar region of the right kidney. The lesion is mainly hypoechoic, extending into the renal sinus.


A 41-year-old pregnant woman diagnosed with renal epithelioid angiomyolipoma associated with pulmonary lymphangioleiomyomatosis. (b) The presence of vascularity is detected within the mass lesion on Doppler examination.


A 41-year-old woman diagnosed with renal epithelioid angiomyolipoma associated with pulmonary lymphangioleiomyomatosis. Transverse chest computed tomography reveals multiple diffuse pulmonary thin-walled cysts (arrowheads).


Contrast CT brain showing skull deposit with extra and intracranial extension.


Contrast CT abdomen showing hepatoma in segment VI.


A; Swelling over left scapular region.


B; Arrow indicates metastatic bone destruction of left scapula.


Intraoperative photo of the left diaphragmatic defect.


Intraoperative photo of the right diaphragmatic injury.


An axial T2 FLAIR image (both arrows) shows bilateral subacute infarct of the thalamus.


FISH images. (A) FISH analysis showed fused red-green signals (negative signal), split red-green signals (positive signal) and single red signals (positive signal) in the patient's biopsy specimen.


FISH images. (B) FISH analysis of typical EML4-ALK fusion gene expression, as the reference. The red arrows indicate cells with positive signals of ALK-fusion events and the green arrows indicate negative signals of non-ALK fusion. Both images were magnified 100 time (x100) under microscope.


A; 3D reconstruction of the ribcage and the 6 metastases with planned trajectories for ablation antennae. View from below, trajectories from dorsal entry.


B; Microwave antenna placed stereotactically within the tumour to be ablated.


CT with oral and IV contrast. Image shows a mass arising from the lesser curvature of the stomach, which does not enhance with IV contrast.


Intraoperative image of the Schwannoma in the lesser curvature of the stomach.


Complete separation of the Schwannoma from the normal stomach.


Cut section of the left-sided Brenner tumor.


Preoperative CT coronal Cut showed left nasal mass with bony invasion.


(A) Monophasic synovial sarcoma with uniform spindle cells arranged in solid sheets.


(B) Perivascular hyalinization and myxoid change.


Immunohistochemistry performed on the biopsy shows diffuse staining for. EMA.


Preoperative MRI T2.


Postoperative CT.


Postoperative and adjuvant radiotherapy, MRI T2.


Intraoral photograph of the patient showing buccal and mild palatal cortical plate expansion of the left maxillary bone.


Axial computerized tomography scan demonstrating the huge mass in the left maxillary sinus.


Photomicrograph of H and E stained section (x40) showing the tumor mass with an extensive ossification abutting the peripheral fibrous capsule.


Pathological findings of the pulmonary metastases from malignant uterine PEComa. . Notes: (A) Hematoxylin and eosin stain, magnification x100.


Pathological findings of the pulmonary metastases from malignant uterine PEComa. (B and C) HMB-45 and SMA immunohistochemical stain, magnification x200.


Pathological findings of the pulmonary metastases from malignant uterine PEComa. (D) Ki-67 immunohistochemical stain, magnification x200. The average Ki-67 labeling index is 40% in this tumor. Background staining was identified by negative controls in which the sections were performed by substitution of primary antibodies with phosphate buffer solution. . Abbreviations: HMB-45, human melanoma black 45; PEComa, perivascular epithelioid cell tumor; SMA, smooth muscle actin.


Follow-up CT scans of the patient. . Notes: (A) Partial response was observed by CT at 3 month after the initiation of the mTOR inhibitor treatment. For example, the size of the largest lesion in lung was reduced from 9 to 4 mm (circle). Some other pulmonary metastases were cavitated (box).


Follow-up CT scans of the patient. (B) Nearly complete response was observed by CT at 7 months after the initiation of the mTOR inhibitor treatment. Fibrosis was observed at the largest pulmonary metastatic focus (circle). No other residual lesion was discernible (box). . Abbreviations: CT, computed tomography; mTOR, mammalian target of rapamycin.


MRI and enhanced MRI: coronary, lateral, sagittal axis. . Notes: MRI shows sheet-like bone destruction area in the left-sided radius, completely or partially discontinuous localized bone cortex, and adjacent soft tissue masses with low-signal intensity on T1-weighted images (A).


MRI and enhanced MRI: coronary, lateral, sagittal axis. T2-weighed images show heterogeneous high signal of. Coronary axis.


MRI and enhanced MRI: coronary, lateral, sagittal axis. Lateral axis.


MRI and enhanced MRI: coronary, lateral, sagittal axis. Enhanced scanning shows heterogeneous enhancement of. Coronary axis.


MRI and enhanced MRI: coronary, lateral, sagittal axis. Sagittal axis. . Abbreviation: MRI, magnetic resonance image.


Pathology and immunophenotyping of primary bone diffuse large B-cell lymphoma, non-GCB (x400). CD20.


Pathology and immunophenotyping of primary bone diffuse large B-cell lymphoma, non-GCB (x400). CD5.


Pathology and immunophenotyping of primary bone diffuse large B-cell lymphoma, non-GCB (x400). PAX-5.


Pathology and immunophenotyping of primary bone diffuse large B-cell lymphoma, non-GCB (x400). MUM-1.


Pathology and immunophenotyping of primary bone diffuse large B-cell lymphoma, non-GCB (x400). Ki67+. . Abbreviation: non-GCB, non-germinal center B-cell-like.


Chest computed tomography (CT) scans were performed and images were recorded prior to any therapies. (A) The arrow shows a 24.1 mmx32.4 mm size lesion in the bottom lobe of the right lung.


Chest computed tomography (CT) scans were performed and images were recorded prior to any therapies. (B) The arrow shows a 49.0 mmx32.6 mm size lesion in the bottom lobe of the left lung.


Chest computed tomography (CT) scans were performed and images were recorded after. The arrow shows a 9.0 mmx9.0 mm lesion in the bottom lobe of the right lung after four cycles of chemotherapy.


Chest computed tomography (CT) scans were performed and images were recorded after. The arrow shows a 41.0 mmx38.0 mm lesion in the bottom lobe of the left lung after fourcycles of chemotherapy.


Chest computed tomography (CT) scans were performed and images were recorded after. The arrow showsa 5.0 mmx5.0 mm lesion in the bottom lobe of the right lung after 2months of icotinib.


Chest computed tomography (CT) scans were performed and images were recorded after. The arrow shows a 55.0 mmx46 mm lesion in the bottom lobe of the left lung after 2months of icotinib.


Axial FDG PET CT fused and CT images shows metabolically active lesion in right neural foramina region.


Axial T1W post contrast MRI image shows enhancing soft tissue thickening in right epidural space corresponding to metabolic activity seen on FDG PET CT image.


The progression of the pituitary lesion in MRI:. A suspicious low signal in the right-wing of the pituitary (January 15, 2019).


Enlargement of the pituitary lesion involving right cavernous sinus (June 28, 2019).


Involvement of the right cavernous sinus, and ,internal carotid artery (September 24, 2019).


A possible macroadenoma, Knosp IV (October 17, 2019).


The lesion in the sellar region involving bilateral cavernous sinus as shown in MRI. Before chemotherapy.


The lesion in the sellar region involving bilateral cavernous sinus as shown in MRI. After two courses of chemotherapy (R2-MTX).


Physical findings on initial examination. The tumor in the left axilla was fist-sized, solid, and immovable. A scar from a biopsy incision overlay the tumor.


Contrast-enhanced chest computed tomography. The tumor in the left axilla measured 11 cm x 7 cm x 11 cm. It had a relatively distinct border, but its surface was irregular.


Pathological autopsy. Metastatic tumor cells were found in the peritoneum, lymph nodes, pharynx, pleura, lungs, pericardium, endocardium, myocardium, liver, omentum, pancreas, splenic hilum, stomach, jejunum, ileum, transverse colon, appendix, and bone marrow. Informed consent to publish this photograph was obtained from the patient before death and from the patient's family after death.


Initial radiologic findings. CT showed the intracerebral hemorrhage of subacute stage on right parietal area (A).


Initial radiologic findings. MRI demonstrates a heterogeneous mixed signal intensity lesion on T1 and T2-weighted images.


Initial radiologic findings. With a small region of enhancement in right parietal region CT: computed tomography, MRI: magnetic resonance imaging.


Pathologic findings. A: Highly cellular with cellular atypia and frequent mitosis (H&E, original magnification x400).


Pathologic findings. B: Immunopositive for CD34 (original magnification x400).


Pathologic findings. C: Immunopositive for actin (original magnification x400).


Pathologic findings. D: Immunopositive for CD31 (original magnification x400).


Follow-up radiologic findings. A and B: Three weeks later, CT and MRI show another intracerebral hemorrhage associated with enhancing lesion of right parietal area.


Follow-up radiologic findings. C: Four weeks later, MRI shows the marginal enhanced lesion on post-resection cavity associated with perilesional edema.


Follow-up radiologic findings. D: After WBRT two months later, MRI shows less than 1 cm-sized, four newly enhancing lesions.


Follow-up radiologic findings. E: Two months later, there are newly developed lesions; 2.3 cm sized hemorrhagic mass lesion with heterogeneous enhancement in right cerebellar hemisphere.


Follow-up radiologic findings. F: Six weeks later, MRI shows that the new multiple lesions are detected. CT: computed tomography, MRI: magnetic resonance imaging, WBRT: whole brain radiotherapy.


A 66-year-old female with external ultrasound showing well-circumscribed hyperechoic mass in the left breast.


A 66-year-old female with breast magnetic resonance imaging shows heterogeneous mass with areas of T1 hyperintensity.


Suppressing on short-tau inversion recovery. In the left breast.


Postcontrast maximum intensity projection image shows irregularly enhancing mass (c).


A 66-year-old female with malignant phyllodes tumor on biopsy of the left breast mass with positron emission tomography-computed tomography scan showing area of mild uptake in left breast (arrow) with no lymphadenopathy or metastasis.


Serial contrast-enhanced computed tomography findings. (A) A gas-containing cavity is seen, suggestive of an abscess within a necrotic mass in the left lateral segment of the liver.


Serial contrast-enhanced computed tomography findings. (B) Communication between the liver abscess cavity and the duodenal bulb is present (arrows).


Serial contrast-enhanced computed tomography findings. (C) The fistulous tract is obliterated and the extent of the abscess has decreased.


Endoscopic findings. (A) The fistula orifice is seen at the proximal portion of the duodenal bulb.


Endoscopic findings. (B) The fistula opening remains visible beside the clips.


Endoscopic findings. (C) The fistula orifice is filled with Histoacryl after Histoacryl injection.


Imaging exams highlighting the injury of the patient. (A): Axial contrast-enhanced CT scan showing neoplastic lesion with an epicentre on the skullcap of the right temporo-occipital transition with intracranial and extracranial expansion.


Imaging exams highlighting the injury of the patient. (B): Sagittal contrast-enhanced CT scan showing the same lesion.


Imaging exams highlighting the injury of the patient. (C): Magnetic resonance imaging shows a highly enhancing tumour with epicentre in the right side of the posterior cranial fossa.


Imaging exams highlighting the injury of the patient. (D): Computerizsd tomography 3 years after the last surgery, the patient accompanied only with chemotherapy and radiotherapy.


Macroscopic examination of hepatic segments IV, V, and VIII. Presence of a solid, whitish tumour with central cystic degeneration measuring 9 x 9 cm.


CT-scan showing a tumoral solid mass at anteroinferior of the right nasal cavity.


Sheet of tumor cells extending beneath the epithelium (H&E stain, 100x).


Papillary and glandular configuration of tumor cells (H&E stain, 250x).


Higher magnification of figure 2 that shows true papilla with fibrovascular core (H&E stain, 400x).


Torax CT showed solid lung mass.


PET-CT scan of the chest revealing high 18F-fluorodeoxyglucose uptake in a patient with lung adenocarcinoma.


MRI of both cruris showed oedema of fascia and muscle and abnormal fascial signal intensity and enhancement.


A. Calcified nodule with "egg-shell" pattern.


B. Microcalcification spots in the same nodule.


A. Macroscopically complete calcified nodule.


B. Calcified rim when cut.


Initial radiography of Lesions. A; Plain film radiography showing the lytic lesions present in the right distal clavicle and humeral head (arrows).


Initial radiography of Lesions. B; T1 MRI of the chest showing the T9 pathologic fracture (arrow).


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. A; Nests of osteoid producing cells can be seen surrounded by swirls of pleomorphic spindle cells and reticular substance. HE x40.


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. B; The tumor is predominantly made up of irregular spindle cells. HE x40.


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. C; The tumor can be seen infiltrating normal bone architecture, HE x40.


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. D; Pleomorphic spindle cells with intervening stroma. HE x200.


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. E; Poorly defended clusters of cells can be seen surrounded by neoplastic stroma, HE x200.


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. F; Spindle cells showing a high degree of pleomorphism, hyperchromatic nuclei, and irregular nuclear contours. HE x200.


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. G; Positive immunohistochemical staining for OSCAR cytokeratin in scattered spindle cells, x200.


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. H; Scattered positive immunohistochemical staining for OSCAR cytokeratin, x200.


Staining of Specimens. Histopathologic features of the T9 biopsy and intraoperative femur stabilization specimens, indicated in lower right corners. I; The same scattered positive immunohistochemical staining for OSCAR cytokeratin is seen in the femur biopsy, x200.


(A) Magnetic resonance imaging revealing a soft tissue mass in the left scrotum.


(B) Surgical piece of the left orchiectomy presenting a 9.5 x 5.0 x 4.5 cm3 paratesticular tumor.


(C) Histopathological section (hematoxylin and eosin staining).


(D) Immunohistochemistry results showing the expression of Desmin.


(E) Immunohistochemistry results showing the expression of MyoD1.


(F) Immunohistochemistry results showing the expression of Myogenin.


(A) Recurrent tumors in the left inguinal region for a duration of 1 month.


(B) Magnetic resonance imaging revealing presence of a soft tissue mass above the left groin and pelvis.


Surgical biopsy of the recurrent tumors from the left inguinal.


Pelvic region. Histopathological section (hematoxylin and eosin staining).


(E) Immunohistochemistry results showing the expression of Desmin.


(F) Immunohistochemistry results showing the expression of MyoD1.


Large distended abdomen with dilated veins.


Intraoperative tumor arising from the right kidney.


Computed tomography images of disseminated coccidioidomycosis lesions. Computed tomography images show: an axial sclerotic bone lesion in December 2020.


Computed tomography images of disseminated coccidioidomycosis lesions. And after 4 months of fluconazole treatment in April 2021.


Computed tomography images of disseminated coccidioidomycosis lesions. , the chest wall mass in December 2020.


Computed tomography images of disseminated coccidioidomycosis lesions. And in April 2021.


Computed tomography images of disseminated coccidioidomycosis lesions. And a right lower lobe lung nodule in December 2020.


Histologic images of chest wall mass biopsy. Hematoxylin & Eosin stained microscopic sections show a diffuse granulomatous inflammation with areas of necrosis (A, 100x, black arrow pointing to necrosis). Rare intact organisms on are consistent with immature spherules of Coccidioides immitis (A, inset, 400x, red arrow pointing to organism).


Histologic images of chest wall mass biopsy. Grocott's methenamine silver stain highlights scattered spherical structures suggestive of yeast forms (B, 400x, red arrow pointing to organism).


Initial chest computed tomography (CT) and microscopic findings of lung cancer, and the chest CT findings after 2 and 5 months of alectinib. A; Multiple masses and nodules are seen in both lungs. The lesions were diagnosed as ALK-positive lung adenocarcinoma.


Initial chest computed tomography (CT) and microscopic findings of lung cancer, and the chest CT findings after 2 and 5 months of alectinib. B; The lung cancer specimen shows an alveolar or sheet-like structure.


Initial chest computed tomography (CT) and microscopic findings of lung cancer, and the chest CT findings after 2 and 5 months of alectinib. C; After 2 months of alectinib administration, all lesions are markedly improved.


Initial chest computed tomography (CT) and microscopic findings of lung cancer, and the chest CT findings after 2 and 5 months of alectinib. D; After 5 months of alectinib administration, the lesions in the left lower lobe of the lung show regrowth (arrow).


Endoscopic and microscopic findings of gastric cancer. A; Conventional endoscopic finding (arrows).


Endoscopic and microscopic findings of gastric cancer. B; Dye endoscopic finding by the indigo carmine contrast method. Prior to nivolumab administration, endoscopy revealed a depressed lesion in the gastric angle region, which was diagnosed as gastric adenocarcinoma (arrows).


Endoscopic and microscopic findings of gastric cancer. C; Microscopically, the gastric cancer specimen has an alveolar or acinus-like structure. The histopathological findings of the gastric cancer are different from those of the lung cancer.


CT findings of lung cancer as well as endoscopy of gastric cancer after nivolumab administration. A; After 5 weeks of nivolumab administration, the lung lesions show marked improvement (arrow).


CT findings of lung cancer as well as endoscopy of gastric cancer after nivolumab administration. B; Conventional endoscopic finding (arrows).


CT findings of lung cancer as well as endoscopy of gastric cancer after nivolumab administration. C; Dye endoscopic finding by the indigo carmine contrast method. After 2 months of nivolumab administration, the gastric lesion diminished in size (arrows).


Computed tomography image of the patient's neck demonstrates a homogeneous increase in the size of the left submandibular gland (arrow). No lymphadenopathy was present.


Coronal CT image shows a retroperitoneal heterogeneous mass infiltrating the inferior vena cava and the left renal vein.


Ultrasound longitudinal image shows classic TM of the right testis without focal lesions.


Coronal T2-weighted MR image shows a large retroperitoneal mass composed by multiple necrotic-colliquative fluid areas with a multilocular appearance.


Papillary thyroid carcinoma with characteristic nuclear features (nuclear crowding, overlapping, clearing, membrane irregularities and inclusions).


Thyroid follicular carcinoma widely invading the thyroid capsule.


Representative histologic images of rhabdomyosarcoma. (A) Malignant mesenchymal tumor, mainly spindle cells, clear cytoplasm or acidophilic tumor cells, severe atypia, large and hyperchromatic nuclei, irregular karyotype, and visible mitotic image.


Representative histologic images of rhabdomyosarcoma. (B) MyoD1 (+) by immunohistochemistry.


Representative histologic images of rhabdomyosarcoma. (C) Myogenin (focal +) by immunohistochemistry.


Timeline of historical and current treatments.


Fundus photographs obtained at presentation of a 69-year-old Japanese man with a history of stage 4 esophageal cancer. A; In the right eye, a veil-like vitreous opacity and retinal whitening in the macular and peripheral retina were apparent. The retinal pigment epithelium appeared to be intact and no choroidal masses or lesions were visible.


Fundus photographs obtained at presentation of a 69-year-old Japanese man with a history of stage 4 esophageal cancer. B; The left eye had an old macular hole, which included hard exudates. No masses or lesions were visible.


Fundus photographs obtained at presentation of a 69-year-old Japanese man with a history of stage 4 esophageal cancer. C; Magnified fundus photograph showed a macular hole in the left eye.


A; Cytological analyses of a vitreous sample, stained with Papanicolaou, revealed scattered, undifferentiated, malignant cells that were consistent with the previous diagnosis of esophageal cancer.


B; Histopathological analysis from the initial esophageal biopsy, stained with hematoxylin and eosin, revealed an anaplastic, squamous neoplasm with cohesive cells. Each sample was observed with a microscope of 400 magnification.


(A) Contrast-enhanced computed tomography (CECT) shows pleural-based heterogenous hypodense mass.


(B) Baseline positron emission tomography-computed tomography shows local disease.


(C) CECT shows large abdominopelvic mass.


(D) CECT shows presacral deposit.


(A) Pleomorphic liposarcoma tumor deposit shows admixture of pleomorphic lipoblasts with epithelioid cells (hematoxylin and eosin, x100).


(B) Pleomorphic liposarcoma tumor deposit shows multivacuolated lipoblasts with indented pleomorphic nuclei (hematoxylin and eosin, x200).


(C) Pleomorphic liposarcoma cells are positive for S-100 (immunohistochemistry, x200).


(D) Pleomorphic liposarcoma cells show diffuse p53 expression (immunohistochemistry, x200).


Chest X-ray. A. Pneumonitis or pulmonary tuberculosis in both upper lobes. A lung mass lesion in the right upper lobe was ruled out.


Chest X-ray. B. Pneumoconiosis such as silicosis with progressive massive fibrosis (PMF). Slightly decreased densities around PMF were present since January 2012. A differential diagnosis for lung cancer, which is rarely considered, was performed.


Chest X-ray. C. Pneumothorax, right. Underlying complicated pneumoconiosis, progressive massive fibrosis. HRCT.


Chest X-ray. D. PMF, subpleural, and centrilobular silicotic nodules (arrows) are seen at both lung and pseudoplaque formation (arrow at pleural area) in the right lung.


Invasive tumor at the level of transverse colon.


Multiple metastatic lymph node invasion in left inferior jugular region, anterior mediastinum, gastric contiguity and abdominopelvis in PET-Scan.


70-year-old male with mild left hip pain and elevated alkaline phosphatase diagnosed with radiogenic osteosarcoma. (a) The planar whole body images of the technetium-99m methylene diphosphonate bone scan demonstrates intense diffuse uptake extending from the left femoral head to the proximal shaft of the femur (double ended arrow).


70-year-old male with mild left hip pain and elevated alkaline phosphatase diagnosed with radiogenic osteosarcoma. (b) The plain film of the left hip depicts three previously unreported fixation screws surrounded by osteopenic lesions (arrow) in the femoral neck and head.


70-year-old male with mild left hip pain and elevated alkaline phosphatase diagnosed with radiogenic osteosarcoma. (a and b) Computed tomography of the pelvis reveal mixed lytic/sclerotic lesions (arrows) within the native bone, although evaluation of the left hip was limited due to streak artifact as seen on the two axial slices in Figure 1.


70-year-old male with mild left hip pain and elevated alkaline phosphatase diagnosed with radiogenic osteosarcoma. Histologic examination of the curettage (using Hematoxylin and Eosin stain, x10) reveals sarcomatous, spindle shaped cells (white arrows) with adjacent tumor osteoid production (black arrows); represented by eosinophilic, amorphous, fibrillary deposits (white arrows) between individual or small aggregates of tumor cells (black arrows).


Neoplastic bone formation and reticulated woven bone.


(A,B) Testis, hematoxylin and eosin stain: scarred area with hyalinized tubular Ghosts (lack arrow), increased vascularity and coarse calcifications (red arrow) within tubular profiles. No viable tumor was identified.


(C) Lymph node, hematoxylin and eosin stain: small foci of metastatic GCT with seminomatous component (black arrows) with associated granulomas (red arrow head).


(D) Immunohistochemical reactivity in tumor cells for CD117 support the diagnosis. CD30 (not shown) is negative.


69-year-old male with blood in the urine was diagnosed with chromophobe renal cell carcinoma. Maximum intensity projection (MIP) image shows omental deposits from chromophobe renal cell carcinoma (arrows).


MRI of esthesioneuroblastoma/inverted papilloma collision tumor. Mass can be visualized in addition to inspissated secretions in the surrounding sinuses.


Nasal endoscopy view of collision tumor.


Hematoxylin and eosin stain - high power of sinonasal inverted papilloma with infiltration of epithelium by atypical cells (esthesioneuroblastoma).


Immunohistochemistry of lesion for synaptophysin (characteristically stains positive in esthesioneuroblastoma).


Immunohistochemistry of lesion for neurofilament stain (characteristically stains positive in esthesioneuroblastoma).


68-year-old man presented with fatigue, dry cough, shortness of breath, and unintentional weight loss. He was finally diagnosed with rectal squamous cell carcinoma. (a) Whole body maximum intensity projection (MIP) fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) image shows widespread metastasis (arrows) of rectal SCC.


68-year-old man presented with fatigue, dry cough, shortness of breath, and unintentional weight loss. He was finally diagnosed with rectal squamous cell carcinoma. (b-d) FDG-PET/CT axial view of rectum show a 4-cm left eccentric intensely hypermetabolic rectal mass (arrows) with maximum standardized uptake value (SUVmax) of 10.6.


The biopsy specimen of case 1: Proliferation composed of trabecular structure. Cylindromatous structures were present. The cribriform pattern was barely seen (Hematoxylin and eosin (HE) x 100).


ACC: combining tubular and solid features (case 2) (HE x 100).


ACC: The tumor cells were small, basaloid, uniform, composed of dense basophilic nuclei with inconspicuous nucleoli (case 1,2) (HEx 200).


ACC: The tumor cells were small, basaloid, uniform, composed of dense basophilic nuclei with inconspicuous nucleoli (case 2) (HE x 200).


The axial T1.


T2 W/FLAIR. Image shows cerebellar vermis lesion that was hypointense on T1WI and heterogeneous on T2WI, vith perilesional edema, and triventricular hydrocephalus.


Preoperative Brain MRI. Brain MRI shows left frontotemporal mass and T2/FLAIR hyperintensity.


Postoperative Brain MRI. Brain MRI after tumor excision showing post-operative changes in the left frontotemporal region.


Biopsy. The mass presented as a well-described, encapsulated lesion.


Lymph node biopsy, showing a follicular lymphoma with brisk TFH response and BCL2-rearrangement. (A) low power view showing a disturbed lymph node architecture, with numerous small follicles arranged in a back-to-back fashion.


Lymph node biopsy, showing a follicular lymphoma with brisk TFH response and BCL2-rearrangement. (B). The follicle centers are composed predominantly of small centrocytes and scattered centroblasts (less than 15/high power field), in the absence of tangible body macrophages.


Lymph node biopsy, showing a follicular lymphoma with brisk TFH response and BCL2-rearrangement. The B-cells in de follicles express CD10.


Lymph node biopsy, showing a follicular lymphoma with brisk TFH response and BCL2-rearrangement. , BCL6.


Lymph node biopsy, showing a follicular lymphoma with brisk TFH response and BCL2-rearrangement. , overexpress BCL2. As illustrated in the anti-BCL2 immunostain. (scale bar: 100 microm).


Lymph node biopsy, showing a follicular lymphoma with brisk TFH response and BCL2-rearrangement. And are intermingled with numerous follicular T-helper cells, as illustrated by a immunostaining against PD1.


Lymph node biopsy, showing a follicular lymphoma with brisk TFH response and BCL2-rearrangement. FISH highlights the presence of a BCL2-rearrangement, corresponding to the BCL2 overexpression in the follicles.


Endoscopy biopsy. Suggested esophageal squamous cell carcinoma.


Postoperative pathology. Demonstrated moderately differentiated esophageal squamous cell carcinoma invading the full thickness of the esophageal wall.


The initial thoracic CT indicated that the middle thickening esophageal wall was markedly enhanced. Plain scan.


The initial thoracic CT indicated that the middle thickening esophageal wall was markedly enhanced. ; arterial phase.


The initial thoracic CT indicated that the middle thickening esophageal wall was markedly enhanced. ; venous phase . Note: Red arrows represent the lymph node. . Abbreviation: CT, Computed tomography.


Cervical CT showed no lymphadenopathy before surgery.


CT showed a significantly enlarged lymph node in the left neck which prompted PD after first-line chemotherapy.


CT revealed the left cervical lymph node was not reduced after radiotherapy and irinotecan treatment.


CT examination showed the swollen lymph nodes significantly narrowed and the border was not clear, suggesting that the patient achieved PR . Note: Red arrows represent the lymph node. . Abbreviations: CT, Computed tomography; PD, disease progression; PR, partial response.


Large pancreatic mass in body-tail region with peripheral enhancement.


Pancreatic tumor infiltrating DJ flexure.


Histology of tumor showing pleomorphic giant cell pattern.


(a) Intraorally: Polypoid, pedunculated growth on gingiva, approximately 2.5 cm x 3.5 cm in size and extending on buccal surface in 43-45 region with Grade III mobility of 43, 44.


(b) Intraorally: After 15 days, showing increased size of growth with necrotic slough.


Intraoral periapical radiograph of 43-44 region showing horizontal bone loss. Widening of lamina dura and mild displacement of 43.


Medical image.


Immunohistochemistry: Cytokeratin positive. Immunohistochemistry: Vimentin positive.


Intraorally, an irregular, localized growth seen on gingiva extending from 34 to 36 region of approximately 2 cm x 2 cm in size, reddish pink in color, soft in consistency, tender on palpation and bleeding on provocation. 35, 36 - Grade I mobile.


Intraoral periapical radiograph shows severe interdental and inter-radicular bone loss in the region of 35, 36.


Photomicrography of the testis tumor (H&E). Panoramic view showing the neoplasia with cystic and solid areas, (100X).


Photomicrography of the testis tumor (H&E). Details of the neoplastic cells, with rounded hyperchromatic nuclei and visible nucleoli, and occasional nuclear infoldings, (400X).


Photomicrography of the testis tumor (H&E). Neoplastic cells arranged in follicular-like structures enclosing watery basophilic substance (C 200X, D 100X).


Photomicrography of the testis tumor. Immunohistochemistry. Calretinin positivity in neoplastic cells (200X).


Photomicrography of the testis tumor. Immunohistochemistry. Diffuse vimentin positivity in neoplastic cells (400X).


Photomicrography of the testis tumor. Immunohistochemistry. Focal inhibin positivity (200X).


Photomicrography of the testis tumor. Immunohistochemistry. Smooth muscle actin (SMA) positivity highlighting the lobular pattern of the tumor (100X).


Multiple pilar cysts were located on the body, extremities and head. One of the lesions on the chest was transformed to SCC.


A closer view of the Figure 1.


Close up of lesions on the trunk.


Pilar lesions on the back of patient.


A close view of the SCC showing large infected ulcer.


Pilar cyst of the scalp.


Pathology of the lesion on the chest showing squamous nests in well-differentiated SCC.


Pathology of pilar cyst showing trichilemmal pattern of keratinization (x400).


A: An esophagogastroduodenoscopy revealed a type-3 tumor at the middle intrathoracic esophagus.


B: A barium esophagography also revealed an irregular stricture of the middle intrathoracic esophagus (white arrow).


A, b: A CT scan revealed the upper mediastinal lymph node swelling and thickening of the esophageal wall.


A: The gross examination of the specimen showed a tumor measuring 45 x 15 mm in consonance with unstained area of iodine staining.


B: The tumor invaded into the adventitia without exposure of the tumor (white arrow) (HE-stain, x 10).


C: A high-power field revealed the tumor cells were poorly differeciated squamous cell carcinoma (HE-stain, x 40).


A: A chest X-ray at 7-year follow-up revealed a solitary pulomonary tumor at right lung (white arrow).


B: A CT scan revealed the tumor with 1.5 cm of diameter.


C: A PET-CT also showed the pulmonary tumor had abnormal uptake with 4.9 of standardized uptake value maximum.


A: A low-power field revealed that there was a well-demarcated tumor with necrotizing compartments (HE-stain, x 10).


B: A high-power field also revealed that the tumor cells proliferated without having basement membrane-like structure (HE-stain, x 40).


An immunohistochemical examination revealed that the tumor cells of primary ESCC were positive for CK14.


CK5/6. (x 10).


An immunohistochemical examination of the lung tumor also revealed that the tumor cells were negative for CK14.


On the other hand, the tumor cells were strongly positive for CK18.


Focally positive for CK5/6. (x 10).


Napsin A.


Synaptophysin.


A huge borderline phyllodes tumor in the right breast of a 44-year-old woman: front image.


Lateral image.


The images of imaging examination. . Notes: (A and B) Mammography (CC) showing a huge right breast, about 23x23 cm and the normal left breast.


The images of imaging examination. (C) Ultrasonography of the right breast showing enlargement obviously; inset, echo intensity disorder and a little blood flow signal.


The images of imaging examination. (D) The CT of right breast showing the mass not invading chest muscle or breaking into the chest cavity. . Abbreviations: CC, craniocaudal; CT, computed tomography.


The resected phyllodes tumor measuring 22x17x14 cm (diameter of the dressing bowl, 16 cm).


The examination images and pathology of the recurrent tumors. . Notes: (A and B) Mammography (MLO) showing the large tumors on the right chest and the normal left breast.


The examination images and pathology of the recurrent tumors. (C) Ultrasonography of the right chest showing the largest tumor about 6.7x4.0 cm.


The examination images and pathology of the recurrent tumors. (D) The tissue section showing spindle-shaped tumor cells that were arranged in bundles or wheels, and mitoses were obvious (200x). . Abbreviation: MLO, mediolateral oblique.


(A) Gadolinium enhanced sagittal and coronal T1 MRI showing diffuse involvement of cauda equina with encasement of conus medullaris (arrows).


(B) Staging whole-body 18F-FDG PET-CT coronal and sagittal views showing hypermetabolic mass in the cauda equina and lumbar nerve root sleeves (arrows).


Follow up MRI.


PET-CT. After chemotherapy showing complete resolution of the hypermetabolic cauda equina lesion. Linear FDG uptake in the posterior lumbar dura (arrows) is postoperative in nature.


Treatment procedure, and timeline of symptoms during the treatment. MRI1, first MRI scan; MRI2, second MRI scan; MRI3, third MRI scan; MRI4, fourth MRI scan; bid, twice daily.


Cranial MRI images. (A and B) Cranial MRI imaging on admission to the department of hematology.


Cranial MRI images. (C and D) Cranial contrast-enhanced MRI imaging on the day before the third course showed that the mass in the cerebellopontine angle area had clearly enlarged.


Cranial MRI images. (E and F) Cranial contrast-enhanced MRI imaging on the day before the fourth course showed that the mass was reduced significantly.


Cranial MRI images. (G and H) Cranial contrast-enhanced MRI imaging on the day before the fifth course showed that the mass disappeared with cicatricial changes.


Histopathological staining revealing a pure squamous cell carcinoma arising from the left ovary, a notable observation in the absence of any concomitant dermoid cyst or endometriosis (stain, hematoxylin and eosin; magnification, x200).


The LUAD patient harboring canonical EGFR-KDD involving exons 18-25. (A) Visualization of canonical EGFR-KDD using the Integrative Genomics Viewer (IGV) browser. The dashed lines indicate the genomic breakpoints.


The LUAD patient harboring canonical EGFR-KDD involving exons 18-25. (B) The genetic and protein domain structures of EGFR-KDD. EGFR/EGFR, epidermal growth factor receptor; KDD, kinase domain duplication; LUAD, lung adenocarcinoma; Recep L, Receptor L domain; Furin-like, Furin-like cysteine rich region; GF recep IV, Growth factor receptor domain IV; KD, tyrosine kinase domain.


Preoperative MRI revealing a left occipital mass mimicking glioblastoma (left upper: T1-weighted image, right upper: T2-weighted image, left lower: diffusion-weighted image, right lower: Gd enhancement).


Intraoperative picture revealing the red fluorescent tumor under 5-aminolevlinic acid fluorescence. No fluorescence.


With fluorescence).


T2-weighted image.


Postoperative MRI at 30 months revealing no recurrence of the lesion in the left occipital lobe. Gd enhancement.


Diffusion-weighted image).


Endoscopic findings: proctoscopy revealed a mass at the anorectal junction.


Hematoxylin and eosin immunohistochemical staining findings for the primary tumors are shown. . Notes: (A) Smaller tumor cells with a diffuse distribution are observed in the anal tumor; hematoxylin-eosin stain, x100.


Hematoxylin and eosin immunohistochemical staining findings for the primary tumors are shown. (B) High magnification microscopy showing a tumor cell morphology similar to that of plasma cells. The nuclei displayed atypia and conspicuous mitotic activity.


Hematoxylin and eosin immunohistochemical staining findings for the primary tumors are shown. (C) Tumor cells showing positive staining for S-100; immunohistochemistry staining, x100.


Hematoxylin and eosin immunohistochemical staining findings for the primary tumors are shown. (D) Tumor cells showing diffuse positive staining for vimentin; immunohistochemistry staining, x100.


Breast ultrasonography images. . Notes: (A) A hypoechoic region sized 1.46x1.26 cm is seen in the outer upper quadrant of the left breast.


Breast ultrasonography images. (B) The mass has atypical characteristics and strip-shaped blood flow around the edges (BI-RADS 4C). . Abbreviation: BI-RADS, Breast Imaging Reporting and Data System.


Immunohistochemical staining findings for the metastatic tumors are shown. . Notes: (A) Metastatic tumor in the left breast showing morphological findings consistent with those of the anorectal melanoma; immunohistochemistry staining, x100. Metastatic tumor cells showing positive staining for Melan-. Immunohistochemistry staining, x100.


Immunohistochemical staining findings for the metastatic tumors are shown. (B) Metastatic tumor cells showing positive staining for vimentin; immunohistochemistry staining, x100.


Immunohistochemical staining findings for the metastatic tumors are shown.


Immunohistochemical staining findings for the metastatic tumors are shown. (D) Metastatic tumor cells showing positive staining for Hmb45; immunohistochemistry staining, x100. Scale bar, 100 mum.


Chest X-ray showing a suspicious consolidation in the right upper lung field and diffuse bilateral haziness.


Surgical lung biopsy specimen showing metastatic carcinoma predominantly in the lymphovascular spaces (H&E stain, x100).


Hematoxylin and Eosin Staining of Pre-Tibial Soft Tissue Nodule. Microscopic hematoxylin and eosin (H&E) section showing (A) large, deep dermal collections of non-caseating granulomas (a, 2x) extending into the subcutaneous tissue (b, 2x). Higher magnification shows tightly formed granulomas containing multinucleated giant cells separated by fibrous connective tissue (c, 4x). Scattered mature appearing lymphocytes are seen surrounding the granulomatous inflammation (d, 10x).


PD-L1 Staining of Pre-Tibial Soft Tissue Nodule. PD-L1 antibody stained section of the granulomatous inflammation shows strong membranous staining of the histiocytes within the granulomas and scattered positive lymphocytes. 4x.


PD-L1 Staining of Pre-Tibial Soft Tissue Nodule. . 20x).


Positron emission tomography/computerised tomography demonstrating elevated tracer uptake in an 8.4-mm left level IV lymph node (red arrow).


Preoperative abdominal contrast-enhanced CT scan showed a well-circumscribed heterogeneously mass in the right suprarenal areal (arrow). Axial sections.


Preoperative abdominal contrast-enhanced CT scan showed a well-circumscribed heterogeneously mass in the right suprarenal areal (arrow). Coronal sections.


Macroscopic features of the tumor showed a well-circumscribed and partially encapsulated solid tumor measuring 5.5x5x3.2 cm in maximum dimension. The normal adrenal gland was displaced by the tumor and presented at the edge of the tumor.


Microscopic details of the tumor. (A) The interlacing bundle and fascicles of the tumor (arrowhead) and compressed adrenal tissue (arrow). (H&E, x 100).


Microscopic details of the tumor. (B) Leiomyosarcoma with nuclear pleomorphism and giant cell formation with mitotic activity in the range of 8-10 mitoses/10 high power fields (H&E, x 400).


Microscopic details of the tumor. (C) Immunohistochemical staining for desmin is positive (x 100).


Microscopic details of the tumor. (D) Immunohistochemical examinations showed strong immunoreactivity for H-caldesmon (x 100).


Immunohistochemical staining for CD117 was positive and specific DOG-1 was diffusely positive.


Liver metastasis. Following.


Prior to chemotherapy.


Abdominal CT-scan showing liver metastasis.


Colonoscopy with primary suspected tumor.


(a) Eyes: light blue, large nut-shaped, separated, slightly oblique.


(b) Fistula in the left maxilla with secretion and foul odor.


14-year-old neutered Mexican male cat. (a,b) Head: in an equilateral triangle. Paws: short, of medium bone, strong musculature, medium-sized feet, round, and compact.


14-year-old neutered Mexican male cat. Polydactyly in the four extremities,. Two accessory fingers preaxially in front.


14-year-old neutered Mexican male cat. One in the back.


Fistula histopathological analysis macroscopic description: (a) Left periocular skin (1.2 x 0.8 cm), homogeneous white surface, broad apical end interspersed with adipose tissue, and irregular edges.


Microscopic description (b) Epidermis with loss of continuity of the epithelium, partially covered by serocellular scabs. Below, poorly demarcated and infiltrating neoplastic flat stratified epithelial tissue arranged in interconnected islands and trabeculae.


(c) Pleomorphic cells with hypereosinophilic cytoplasm with small vacuoles; one or two prominent, pleomorphic nuclei with fine granular chromatin; 7 atypical mitoses/10 randomized fields (400X), anisocytosis and anisokaryosis.


(d) Marked desmoplasia, and some nests, the neoplastic cells (also present in surgical border) are organized around concentric sheets of keratin (keratin beads). Diagnosis- Squamous cell carcinoma well-differentiated proliferative cells, generalized moderate ulcerative epidermitis.


CECT showing the heterogeneously enhancing mass arising from the pancreas.


Operative and postoperative image.


Specimen with tumour and spleen.


Hematoxylin and eosin staining.


S100 staining.


PET scan.


PET scan demonstrated no abnormal FDG processes throughout the body. Large right-sided pleural effusion was present, but without any hypermetabolic activity (arrows).


Medication strategy and disease conditions of the patient during the treatment. (A) An illustrated summary of the treatment received by the patient.


Post-contrast sagittal magnetic resonance (MR) image of dorsolumbar spine shows a discrete intramedullary conus tumor opposite D12 vertebra.


Post-contrast sagittal MR image of dorsolumbar spine shows the conus tumor and posterior laminectomies after first surgery.


Chest radiograph demonstrates a right hilar mass.


Intraepithelial neoplasia lesion located on the ventral side of the penis (A).


Complete resection of the lesion tissue on the surface of the penile deep fascia (B).


The penile surgical area was covered with a pedicled scrotal flap (C).


The shape of the penis after lesion resection and plastic surgery (D).


The surgical area of the penis of the patient is not completely healed half a month after the operation (E).


Penile morphology after complete wound healing (F).


Pathological image of the penile intraepithelial neoplasia lesion with H&E staining, original amplification x100, scale bar 100 mum (A).


Pathological image of the penile intraepithelial neoplasia lesion with H&E staining, original amplification x200, scale bar 100 mum (B).


Imaging of scalp nodules, lung cancer, and its metastatic lesions. . Notes: (A, B) Multiple nodules in scalp and neck regions.


Imaging of scalp nodules, lung cancer, and its metastatic lesions. (C) Brown spots in the labial mucosa.


Imaging of scalp nodules, lung cancer, and its metastatic lesions. (D) A large tissue mass occupied the upper lobe of the left lung on PET-CT.


Imaging of scalp nodules, lung cancer, and its metastatic lesions. (E) Multiple bones metastasis with increased metabolism on PET-CT.


Imaging of scalp nodules, lung cancer, and its metastatic lesions. (F) Multiple ring-enhanced lesions in the brain parenchyma on Gd-enhanced MRI. . Abbreviation: PET-CT, positron emission tomography-computed tomography.


Histopathologic finding of scalp lesions. . Notes: (A, B) Hematoxylin and eosin staining showed circumscribed tumors in the middle and deep dermis, with tubulopapillary structures. Numerous papillary folds projecting into the cystic spaces were also seen.


Histopathologic finding of scalp lesions. (C) High magnification showed round or oval nuclei, and some cells revealed atypia. Each of the numbers HE 40, HE 200, and HE 400 denotes the magnification of a microscope.


Histopathologic finding of scalp lesions. Immunohistochemical staining showed that nuclear negativity for P63.


Histopathologic finding of scalp lesions. And CK5/6.


Histopathologic finding of scalp lesions. Positivity for GCDPF-15.


Histopathologic finding of scalp lesions. , CK7.


Histopathologic finding of scalp lesions. TTF-1 . Abbreviation: HE, hematoxylin and eosin.


Imaging of lung cancer on CT. . Notes: (A) Large masses involving the left upper lobe associated with extensive mediastinal lymphadenopathy in June 2016.


Imaging of lung cancer on CT. (B) After the first cycle of chemotherapy for 1 month, the large tissue masses in the lung decreased in size in July 2016.


Imaging of lung cancer on CT. (C, D) The decreasing tissue masses in the lung on a followed-up CT in September 2016 and November 2016. . Abbreviation: CT, computed tomography.


A) Abdominopelvic CT scan with I/V contrast report showing 2 lesions in the pancreas.


B) Coronal section demonstrates the cystic lesion with IV contrast.


Intraoperative picture demonstrates the teratoma.


Histopathology showing mixed embryonic cell. A) Lymph node with metastatic cystic neoplasm.


Histopathology showing mixed embryonic cell. B) Cyst lining is formed of nonkeratinized squamous epithelium.


Histopathology showing mixed embryonic cell. C) Cyst also entangling glandular and smooth muscle elements.


Histopathology showing mixed embryonic cell. D) Areas of hyaline cartilage.


Breast ultrasound showing hypoechoic mass in the right breast (BI-RADS 4a) (green box).


On per speculum examination, cauliflower-like growth was seen.


Sagittal T2-weighted magnetic resonance imaging shows T2 hyperintense mass (M) in the pelvis causing inversion of the uterus (U) seen as "V-shape" fundus.


Axial T2-weighted magnetic resonance imaging shows inverted uterus (U) with "Bull's eye" configuration.


Axial T2-weighted magnetic resonance imaging at a lower level shows the mass (M).


x10 is showing sprinkling positivity of CD10, consistent with high-grade stromal sarcoma.


It showing frank areas of endometrial stromal tumor with foci of heterologous cartilaginous formation.


Intraoperatively, vas-like appearance was seen.


Gangrenous digits of the patient.


Ulcerated jugulodigastric node.


Histological specimen of jugulodigastric lymph node. Notes: (A) Biopsy from the ulcerated jugulodigastric node showing spindle cell carcinoma.


Histological specimen of jugulodigastric lymph node. (B) Cytology smear from the ulcerated jugulodigastric node showing spindle cell carcinoma.


Lymphangitis carcinomatosis involving the right lobe and mediastinal adenopathy.


CECT scan of neck showing irregular lesion along the medial margin of left vocal cord at the junction of anterior one third and posterior two thirds. There is thickening of left true vocal cord with loss of paraglottic fat, suggestive of a neoplastic lesion. The normal paraglottic fat on right side is seen as black area just deep to the thyroid cartilage (seen as white). The airway is seen as black oval structure.


Fiber-optic laryngoscopy showing irregular lesion along the medial margin of left vocal cord in the anterior part.


Histopathological slide of left vocal cord lesion in low-power field showing full-thickness severe dysplastic changes of epithelium.


High-power field of the same histopathological slide [Figure 3], showing a more detailed view.


A 2.0-cm duodenal ulcer covered by yellowish debris tissue with two openings at the ulcer base.


The guidewire was passed through one of the two openings.


One of the openings was a hepaticoduodenal fistula.


A plastic stent (10 Fr, 7 cm) was inserted into the left intrahepatic duct.


Bone marrow aspiration results: Wright-Giemsa staining (magnification, x 1,000).


Computed tomography shows a 3x4 cm sized mass (arrow) in the left cerebellar hemisphere.


Serum LDH of patient treated with RT plus nivolumab. Serum LDH decreased from 1,000 U/L at the beginning of therapy to 215 U/L at 4 months. Serum LDH has been maintained within normal limits (125-250 U/L) until present.


Treatment timeline. Treatments and responses from diagnosis until present.


(A, B, C) Preoperative CT showed a subdural hematoma with midline shift.


Intraoperative pictures of extracalvarial.


Intracalvarial.


Extradural.


Intradural metastases.


Postoperative CT showing evacuation of the hematoma and resolution of the midline shift.


Diffuse infiltrating tumor with undifferentiated cells (H&E, x100).


Immunoreactivity against PSAP in tumor cells (PSAP, x400).


Representative images of the patient. (a) Skin metastases.


Representative images of the patient. (b) HE staining of skin lesion. The skin metastasis of adenocarcinoma and tumor thrombus (arrow) was found in vessels. Scale bar: 200 mum.


Representative images of the patient. (c) HE staining results of duodenum biopsy, showing primary adenocarcinoma of the descending duodenum. Scale bar: 200 mum.


Magnetic resonance imaging preoperatively and postoperatively. Representative. Sagittal.


Magnetic resonance imaging preoperatively and postoperatively. Coronal images of T1-weighted postcontrast magnetic resonance imaging (MRI) are shown at time of presentation.


Magnetic resonance imaging preoperatively and postoperatively. Intraoperative MRI was obtained, demonstrative gross total resection of the sellar tumor, as seen on representative. Sagittal.


Magnetic resonance imaging preoperatively and postoperatively. Coronal images of T-weighted postcontrast MRI.


CT scans show multiple tumors in the right kidney (
A and
B). Gross examination displays a yellowish central tumor with solid-cystic areas corresponding to a clear cell renal cell carcinoma (
C) and four peripheral whitish tumors and several intrarenal micronodules corresponding to biphasic squamoid alveolar renal cell carcinomas (
C and
D).


Panoramic view of both tumors, Biphasic squamoid alveolar renal cell carcinoma (BSARCC) (
A and
B) and conventional renal cell carcinoma (CCRCC) (
C and
D). BSARCC displayed some areas of type1 papillary renal cell carcinoma. Right side), and . Presented the typical alveolar structures filled with large cells. Left side and
B). CCRCC showed solid and cystic areas composed of nests low-grade cells with clear cytoplasm (
C and
D).


Abdominal computed tomography 6 month after excision of metastatic adrenal hepatocellular carcinoma.


Bilateral cystic adnexal mass . Note: The yellow circles highlight the whole cystic adnexal mass.


With a solid region. And the solid region.


Low-resistance neo-vascularization on ultrasound The pink circle highlights the low resistance neovascularization (C).


CT scan findings of a lobulated cystic mass with septation . Note: Yellow circles highlight the cystic mass.


Papillary projections on the left adnexum. And papillary projections.


Intra-operative findings of a normal uterus and both ovaries, with enlargement of both fallopian tubes.


CT scan of the neck showing a normal thyroid gland.


Histopathology image of the thyroid tissue suspicious for PTC.


Histopathology image of the thyroid tissue showing florid Hashimoto's thyroiditis.


ACTH induced hyperpigmentation.


CT image showing heterogenous multilobulated pelvic lesion.


Ga-68 DOTANOC PET-CT showing pelvic lesion with no SSTR avid disease.


(C) FDG PET-CT showing FDG hypermetabolism of the pelvic lesion.


Large right ovarian tumour, 2 left ovarian cysts, and ,omentum.


Ruptured right pelvic tumour, uterus with left ovarian tumour.


ACTH trend since diagnosis and corresponding normal range. Difference in ACTH cut-offs before and after 22 months was due to a change in assay used.


Image showing right sided peri-orbital swelling.


Image showing abnormal hyperostotic changes within the right orbit in the computed tomography scan.


Image showing enhancing lesion in the right globe (black arrow) with extension to para-nasal sinuses (brown arrow) and invasion to the dura of anterio cranial fossa (white arrow).


Chest X-ray showing elevated right hemi-diaphragm (white arrow) and right para-hilar mass.


Chest computed tomography revealing presence of right para-hilar lung mass (white arrows).


Fine needle aspiration cytology from the lung mass revealing the presence of malignant cells.


Computed tomography image revealing the presence of invasion of para-nasal sinuses by the lesion.


Coronal neck and chest CT scan:. Hypodense nodule with coarse calcifications the middle third of the right thyroid lobe (red arrow).


Hypodense nodular formation in the left thyroid lobe (red arrow), multiple laterocervical lymph nodules (yellow arrows).


Axial CT scan of the chest: pulmonary micronodules suggestive of lung metastases measuring a maximum of 0.4 cm.


Sagittal and coronal FDG-PET images: right multiple laterocervical, submandibular and supraclavicular lymph nodes, with intense uptake of FDG.


Thyroid ultrasound: transverse and longitudinal section: two lymph nodes with coarse calcifications in the right thyroid lodge, measuring 1.18/0.94/1.17 cm and 1.05 cm respectively.


CT of patient before treatment. (a) Contrast-enhanced multi-detector CT. A 10 cm x 7 cm liver lesion (blue arrows with main diameters) completely occupying the left lobe in a multi-deposit disease is compressing and dislocating the stomach (red arrows).


CT of patient before treatment. (b) 3D rendering image pre-treatment.


Slit-lamp findings for the left eye. Dense vitreous hemorrhage was detected (arrow).


Postoperative findings. A; Fundus photography for the left eye 2 months after surgery. The optic disc and the macula exhibited a normal color. Numerous fine retinal folds were also observed.


Postoperative findings. B; Optical coherence tomography findings for the left eye. While the shape of the central fovea was normal, the external limiting membrane was absent, and the inner segment ellipsoid line was extremely thin and not continuous under the fovea.


An axial contrasted computed tomography scan of the chest showing enlarged main pulmonary trunk suggesting pulmonary hypertension and extensive mediastinal lymphadenopathy.


Microscopic slides of sections of the lungs showing intravascular collections of fibrin and markedly anaplastic tumour cells consistent with poorly differentiated adenocarcinoma. (A) A slide showing tumour cells with associated thrombus in the pulmonary vessels (arrows). Haematoxylin and eosin stain. Original magnification 100x.


Microscopic slides of sections of the lungs showing intravascular collections of fibrin and markedly anaplastic tumour cells consistent with poorly differentiated adenocarcinoma. (B) A slide showing recanalization of a thrombosed pulmonary blood vessel. Note the individual tumour cells (arrows). Haematoxylin and eosin stain. Original magnification 200x.


Microscopic slides of sections of the lungs showing intravascular collections of fibrin and markedly anaplastic tumour cells consistent with poorly differentiated adenocarcinoma. (C) A slide illustrating intracytoplasmic mucin vacuoles in tumour cells (arrows). Periodic acid-Schiff stain treated with diastase. Original magnification 400x.


Microscopic slides of sections of the lungs showing intravascular collections of fibrin and markedly anaplastic tumour cells consistent with poorly differentiated adenocarcinoma. (D) A slide illustrating positive staining (brown stain) of tumour cells with an immunohistochemical stain (cytokeratin cocktail) for AE1/AE3 in keeping with a carcinoma rather than a lymphoma or melanoma. Original magnification 100x.


Imprint from bone marrow biopsy. Giemsa stain. x1,000.


Bone marrow trephine biopsy. A; Intertrabecular space completely filled by angiosarcoma. The lesion shows multiple anastomosing vascular channels (HE. X100).


Bone marrow trephine biopsy. B; Vascular spaces lined by endothelial cells with mild to moderate atypia, surrounded by spindled neoplastic cells (HE. X400).


Immunohistochemical staining of the bone marrow biopsy. A CD31 positivity in neoplastic cells (x400). B; Factor VIII positivity in neoplastic cells (x400).


Patient with a large abnormal swelling on the right side of face.


Enhanced CT scan demonstrating a right adrenal mass of low density.


Microscopic appearance of the adrenal tumor showing a well-differentiated adenocarcinoma, similar to the primary rectal carcinoma (H&E x100).


Chest X-ray.


Enhanced CT. Demonstrated a lung mass in the right upper lobe with hilar and mediastinal lymph nodes metastases invading the lower trachea and carina. They also showed occluded right mainstem bronchus and atelectasis of the right lung.


Fiberoptic bronchoscopic images of the lower trachea after the Ultraflex covered stent placement in the right mainstem bronchus (white arrow) demonstrated a deformed and stenosed lower trachea (D).


After stent placement in the lower trachea (E), the deformity ameliorated.


The procedure in detail. The tumor progressed quickly and resulted in severe stenosis of the carina 2 weeks later. Furthermore, there was tumor ingrowth and overgrowth to the distal end of the lower trachea stent and the proximal end of the right mainstem bronchus stent (A).


The procedure in detail. The tumor progressed quickly and resulted in severe stenosis of the carina 2 weeks later. Flexible 0.035-inch guidewires were carefully inserted into the existing stent and the left mainstem bronchus (B).


The procedure in detail. The tumor progressed quickly and resulted in severe stenosis of the carina 2 weeks later. Bilateral Ultraflex covered stents were advanced over the guidewires to the bilateral mainstem bronchi, and the right stent was carefully released (C).


The procedure in detail. The tumor progressed quickly and resulted in severe stenosis of the carina 2 weeks later. After confirming full expansion, the left stent was also immediately released by adjusting the proximal end to the right counterpart that was precisely tuned by forceps (D).


Images after two cycles of combination chemotherapy: chest X-ray The atelectasis of the right lung disappeared.


Enhanced CT the bilateral stents were patent and adjacent to each other with regression of the main tumor and lymph nodes metastases.


Multiplanar reconstruction coronal images The atelectasis of the right lung disappeared Each proximal ends was in line with each other without displacement (D).


Histopathology of bone marrow biopsy showing scattered infiltration of atypical large lymphocytes. (A) Low-power view of the bone marrow biopsy (H&E stain, x50).


Histopathology of bone marrow biopsy showing scattered infiltration of atypical large lymphocytes. (B) High-power view of the atypical lymphocytes (H&E stain, x200).


Histopathology of bone marrow biopsy showing scattered infiltration of atypical large lymphocytes. (C) Immunohistochemical staining of CD20-positive lymphoproliferative cells (x400).


Histopathology of bone marrow biopsy showing scattered infiltration of atypical large lymphocytes. (D) EBER in situ hybridization indicating positive signals in the nuclei of background cells (x200).


Photomicrography of the nodal biopsy. (A) Low-power view reveals effaced structure by marked infiltrate of small-to-medium-sized atypical lymphocytes with clear cytoplasm (H&E stain, x100).


Photomicrography of the nodal biopsy. (B) High-power view showing polymorphous lymphoid infiltrate with high endothelial venules (H&E stain, x400).


Photomicrography of the nodal biopsy. (C) Immunohistochemically, large immunoblastic lymphocytes were positive for CD20 (x400).


Photomicrography of the nodal biopsy. (D) Podoplanin immunostain revealed expanded follicular dendritic cell meshwork (x400).


Photomicrography of the nodal biopsy. (E) EBER in situ hybridization followed by PD-1 immunostaining showed that lymphoma cells were negative for EBER.


Photomicrography of the nodal biopsy. (F) EBER in situ hybridization followed by the immunostaining of CD20 indicated positive-signal lymphocytes infiltrate indicating positive signals in the nuclei of background cells (x600).


Computed tomography scan with the yellow arrow pointing at the tumor.


Resection specimen with the yellow arrow pointing to the tumor in the common bile duct.


Poorly differentiated carcinoma of the common bile duct on hematoxylin and eosin stain x 400.


Cumulative summary report of serum Na level.


Fundus photographs. Right eye.


Left eye).


Goldmann visual field perimetry findings. Left eye.


Right eye) obtained before the first operation in 2010. Fundus examination showed predominant optic disc atrophy in the right eye. Goldmann perimetry findings showed bitemporal hemianopia, and in detail, complete temporal loss and inferonasal defect in the right eye and defects in the temporal half of the left eye.


MRI images of the patient's head obtained before the first operation in 2010 and before the second operation in 2017. Before the first operation in 2010, the MRI sagittal.


MRI images of the patient's head obtained before the first operation in 2010 and before the second operation in 2017. Coronal section. Showed a giant cystic mass approximately 4 cm in diameter extending from the intrasellar region to the sphenoid sinus and the suprasellar region.


MRI images of the patient's head obtained before the first operation in 2010 and before the second operation in 2017. Before the second operation in 2017, the MRI sagittal.


MRI images of the patient's head obtained before the first operation in 2010 and before the second operation in 2017. Coronal section. Showed a giant cystic mass larger than 8 cm in diameter in the suprasellar region (T1-weighted image).


Histopathological finding of the tumor tissue collected at the first operation. Hematoxylin, and ,eosin stain.


Immunostaining for ACTH). Immunostaining of the tumor tissue, which was collected intraoperatively, showed adrenocorticotropic hormone (ACTH)-positive cells.


Gadlinium-enhanced T1 weighted MRI. Axial image showing enhancing mass lesion in right occipital lobe.


Postoperative gadlinium-enhanced T1 weighted MRI. Axial image showing complete resection of lesion.


Vimentin immuno caption: Strong cytoplasmic positivity for vimentin indicative of mesenchymal differentiation; pan-cytokeratin and GFAP immunohistochemical stains were negative (x100).


Contrast enhanced computed tomography chest showing left hilar mass marked with arrow.


Contrast enhanced computed tomography hip region showing muscle metastasis with underlying bone.


Lung biopsy showing squamous cell carcinoma - both high power and low power view.


Biopsy of muscle metastasis (iliacus muscle) showing squamous cell carcinoma deposit.


Flexible nasopharyngolaryngoscopy view of the right BOT mass before treatment.


After 3 cycles of R-CHOP chemotherapy.


After the completion of 6 cycles of R-CHOP chemotherapy.


A; Baseline whole-body MIP image demonstrating intense FDG uptake in a large retroperitoneal mass (red arrow) compatible with patient's follicular lymphoma. Showing the large, FDG-avid mass (red arrow). Note the common bile duct stent (red arrowhead) that is markedly anteriorly displaced by the lymphomatous mass and explains the patient's presentation with obstructive jaundice. C Whole-body MIP image following three cycles of R-CHOP shows no residual metabolically active lymphoma.


Representative axial PET/CT image from the same time point as in.


Is notable for the presence of minimal residual abnormal soft tissue in the retroperitoneum (red arrow, Lugano 2), with uptake equal to blood pool, compatible with a complete metabolic response. The common bile duct stent is in near-orthotopic location now that the retroperitoneal mass has dramatically reduced in size (red arrowhead). E Whole-body MIP image at the end of therapy, again demonstrating no metabolically active tumor.


Again depicts the complete metabolic response (Lugano 1) and also the removal of the common bile duct stent.


CT image of the chest revealing a mass arising from the right chest wall (arrow).


Intraoperative findings showing multiple plaques and the extrapleural tumor.


A; The resected specimen, 25 x 10 x 5 cm in size.


B; Microscopic examination result showing a lobulated growth pattern of cartilaginous cells of histological grade 1.


PET-CT scan (November 2016) and histopathological results after postoperative recurrence.


PET-CT scan (November 2016) and histopathological results after postoperative recurrence. Solitary right pulmonary nodule.


PET-CT scan (November 2016) and histopathological results after postoperative recurrence. Enlarged right hilar lymph node were found and identified as metabolically active lesions (SUVmax = 8.32).


PET-CT scan (November 2016) and histopathological results after postoperative recurrence. (D,E) Subcarinal lymph node enlarged with intense FDG uptake (SUVmax = 13.19).


PET-CT scan (November 2016) and histopathological results after postoperative recurrence. (F) Holistic view of PET-CT: metabolic lesions in the lung, hilum, and subcarina.


PET-CT scan (November 2016) and histopathological results after postoperative recurrence. (G) Histopathological features of CT-guided biopsy tissue of the nodule in the right upper lobe: alveolus tissue with some naked nuclear-like lymphocytes. (x20 hematoxylin/eosin).


PET-CT scan (November 2016) and histopathological results after postoperative recurrence. (H) Histopathological features of EBUS biopsy tissue of the subcarinal lymph node: cancer cells arranged in disperse or the nest bulk in mucoid tissue (x20 hematoxylin/eosin).


PET-CT scan (November 2017) and histopathological and molecular results after gefitinib therapy resistance. (A,B) Original mass in the upper lobe of the right lung enlarged (1.4 x1.1 cm) with more intense FDG uptake (SUVmax = 11.24).


PET-CT scan (November 2017) and histopathological and molecular results after gefitinib therapy resistance. (C,D) Right hilar and subcarinal lymph node enlarged with more intense FDG uptake.


PET-CT scan (November 2017) and histopathological and molecular results after gefitinib therapy resistance. (E-G) New mediastinal, right subclavian, and bilateral cervical lymph nodes were found with FDG uptake.


PET-CT scan (November 2017) and histopathological and molecular results after gefitinib therapy resistance. (H) Holistic view of PET-CT: metabolic lesions in multiple metastases. Histopathological features of ultrasound-guided biopsy tissue.


PET-CT scan (November 2017) and histopathological and molecular results after gefitinib therapy resistance. (I) Cancer cells arranged in streaks and nest bulk and invasive growth manner in left cervical lymph nodes (x20 hematoxylin/eosin).


PET-CT scan (November 2017) and histopathological and molecular results after gefitinib therapy resistance. (J) HER-2 amplification was detected by FISH in left cervical lymph nodes tissue. HER-2 signal (red) was found in clusters distributed.


PET-CT scan (November 2017) and histopathological and molecular results after gefitinib therapy resistance. (K) Irregular adenoid and cord-like cancer cells were found in the biopsy tissue from the nodule in the upper lobe of the right lung (x20 hematoxylin/eosin).


PET-CT scan (November 2017) and histopathological and molecular results after gefitinib therapy resistance. (L) Cancer cells scattered or arranged in groups observed in right hilar and subcarinal lymph nodes tissues acquired by EBUS-guided biopsy (x20 hematoxylin/eosin).


PET-CT (May 2018) scan after 6 cycles of combination treatment with trastuzumab, vinorelbine, and capecitabine. (A-F) All metastases shrank with almost no FDG uptake.


Before treatment: multiple lesions in the face and scalp are noted, consistent with extensive BCC.


Dose volume histogram (DVH) of the composite plan showing 96 % of the CTV (Red) covered by 60 Gy. V30 of the brain (orange) is less than 20%. The remaining lines represent the dose to the optic nerves (green) with a maximum < 25 Gy, respectively, left lens (cyan) 11 Gy and right lens (magenta) 16 Gy (late formation of cataracts could be expected). The maximum doses to the optic chiasm (dark blue) and brainstem (brown) were less than 16 Gy.


A 69-year-old man with castration-resistant prostate cancer was treated with radium-223 therapy. A; The first 11C-choline PET/CT showed multiple osteoblastic lesions and abnormal 11C-choline uptake in the spine and pelvis, suggesting viable tumors.


A 69-year-old man with castration-resistant prostate cancer was treated with radium-223 therapy. B; The second 11C-choline PET/CT at the end of the radium-223 therapy showed a decrease in existing 11C-choline uptake, but multiple new appearances of osteoblastic and nonosteoblastic lesions with abnormal 11C-choline uptake in the spine, pelvis, ribs, and femur, suggesting multiple viable bone metastases. We can assume progressive metabolic disease according to the two 11C-choline PET/CT scans.


Postoperative X-Ray demonstrated T5 corpectomy and spinal fusion helping expandable cage, screw and rod.


Initial brain MRI showing a cystic mass in the left frontal region, presented on axial plain, T1-weighted image (a-c).


Control brain MRI, after initial biopsy and conformation on diagnosis; supratentorial recurrent tumor mass in the left frontal region with the cystic part in the superior frontal gyrus was revealed, presented on T2-weighted image on coronal.


Axial plain.


Control brain MRI, 6 months after initial diagnosis, after childbirth revealed a supratentorial recurrent tumor mass in the left frontal region with the cystic part in the superior frontal gyrus, presented on T1-weighted image with contrast enhancement on coronal.


Microphotography of a pathohistological section showing histological and immunohistochemical features of a tumorous tissue stained with. Hematoxylin, and ,eosin, original magnification of x100.


Synuclein, original magnification of x100.


Proliferation index Ki67, original magnification of x200. Tumor consisted out of atypical astroglial cells and high mitotic activity. Extensive microvascular proliferation of individual blood vessels was described, as well as focal points of tumor necrosis. Ki67 proliferation index higher was than 50%. According to the WHO classification, it corresponded glioblastoma multiforme, WHO Grade IV.


(a-f) Control MRI 2 years after initial diagnosis revealed expansive neoplastic masses in the right frontal region, left frontal region with rectal and orbital gyri and pericallosal area affected and in left temporal region, along with necrotic zones.


Chest computed tomography (CT) showed multiple space-occupying lesions. The arrows indicate the lesions.


Bronchofibroscopic biopsy revealed SCC with opening of right upper lobar bronchus.


TBNA found cancer cells in 4R.


7 lymph node groups . Abbreviations: SCC, squamous cell carcinoma; TBNA, transbronchial needle aspiration.


Computed tomography showing the intestinal tumor.


Computed tomography showing the abdominal wall recurrence.


WBC gradually increased postoperatively. . Notes: "A" represents the day the patient took hydroxyurea 0.5 g tid po; "B" represents the day the patient took hydroxyurea 1.0 g tid po; "C" represents the day the patient took hydroxyurea 2.0 g bid po; "D" represents the day the patient took hydroxyurea 1.0 g tid po; "E" represents the day the patient did not take the hydroxyurea; "F" represents the day the patient took hydroxyurea 1.0 g tid po. The patient was discharged on March 30, 2015. . Abbreviations: bid, twice daily; po, per os; tid, three times a day; WBC, white blood cell.


Bone marrow biopsy (hematoxylin and eosin 10x40).


Immunohistochemistry (MPO 10x40). . Abbreviation: MPO, myeloperoxidase.


Octreoscan showing the gastric mass (top image) and ovarian lesion (bottom image).


A; Coronal maximum intensity projection (MIP) of 18F-FDG PET imaging before admission. Accumulation was found in the stomach, in the right hepatic lobe, in the extensive lymph node metastases, and in the whole thyroid gland.


B; Transverse section of the thyroid on 18F-FDG PET/CT imaging before admission. Diffuse uptake in bilateral thyroid lobes was observed.


C; Transverse section of the thyroid on CT imaging after admission. The thyroid gland was diffusely swollen. Its size enlarged and its CT value decreased after hospitalization. In addition, the adipose tissue concentration in the surrounding area increased.


Cytology specimen that was obtained by fine-needle aspiration from the right lobe of the thyroid gland (Papanicolaou stain; original magnification x400). Discohesive atypical cells with irregular hyperchromatic nuclei containing prominent nucleoli were present. Round-shaped cells with cytoplasmic mucin vacuoles and eccentrically placed nuclei were signet-ring-cell carcinoma cells (arrow). Cells with a high nuclear-to-cytoplasmic ratio were thought to be poorly differentiated adenocarcinoma cells (arrowhead). There were numerous mitotic figures (big arrowhead). Based on these findings, the thyroid lesion was defined as "malignant" (metastatic carcinoma) by TBSRTC.


Preoperative axial.


Sagittal.


Coronal. T1-weighted MRI with gadolinium enhancement showing a heterogeneous enhancing mass in the right frontal lobe.


Axial (D) T1-weighted MRI with gadolinium enhancement performed 2 years after the first surgery showing no residual or recurrent tumors.


Axial (E) T1-weighted MRI with gadolinium enhancement performed 6 years after the initial presentation showing the first recurrence.


Photomicrographs (magnification x200) of oligodendroglial cells in the brain tumor Hematoxylin-eosin staining showed proliferation of tumor cells with relatively round nuclei and a loose, myxoid-like background (A, D).


Photomicrographs (magnification x200) of oligodendroglial cells in the brain tumor Immunohistochemical staining showed positive results for CD56.


Photomicrographs (magnification x200) of oligodendroglial cells in the brain tumor. And Olig2 Scale bars: 100 mum.


The metastatic bone marrow tumor Hematoxylin-eosin staining showed proliferation of tumor cells with relatively round nuclei and a loose, myxoid-like background (A, D). Normal hematopoietic tissue replaced by a malignant tumor (D).


The metastatic bone marrow tumor Immunohistochemical staining showed positive results for CD56.


The metastatic bone marrow tumor. And Olig2 Scale bars: 100 mum.


CT scan of the pelvis (A) showing an osteoblastic lesion in the left sacral wing (arrowhead).


PET-CT scan . Proximal appendicular skeleton. White arrows.


Bone scintigraphy. Showed multiple high-uptake bony lesions throughout the axial, and . . Black arrows).


A; Distention of the gallbladder with gallstones and mild thickening of the wall.


B; Cholangiogram during ERCP showing distal bile duct stricture requiring sphincterotomy, balloon sweep, and stent placement.


C; H&E stained tissue section showing metastatic high grade breast ductal adenocarcinoma in the submucosa of the gallbladder (200 magnification; 20x).


D; GATA3 immunohistochemically-stained tissue section positive in the metastatic adenocarcinoma, helping to confirm a breast primary (200 magnification; 20x).


T1-weighted head and neck magnetic resonance image (MRI) with fat saturation revealed a 2.6 centimeter enhancing soft tissue lesion occupying the right carotid space and the right parapharyngeal space at the level of carotid bifurcation with right internal and external carotid artery encasement (Open arrow).


Post-treatment T1-weighted head and neck MRI showed decreased size of the right carotid body tumor with slightly anterior displacement of the right parapharyngeal fat (Arrow head).


Proliferation suppression of circulating sarcoma cells, more than 80% of growth inhibition, was observed for doxorubicin, eribulin, gemcitabine, olaratumab/doxorubicin combination, and pazopanib.


The photograph shows purpura on both legs. (A) Anterior view of the tibia.


The photograph shows purpura on both legs. (B) Anterior view of the ankle.


(A) The vaginal specimen in the operation room.


(B) The perineal appearance 7 days after the operation.


(A) Gross photography of the specimen.


(B) Microscopic findings of the vaginal intraepithelial neoplasia III (H&E, x100).


Magnetic resonance image demonstrates a 3.0x2.5 cm size solid mass with mildly enhancement on left kidney lower pole with a central necrotic portion.


Left kidney coronal opening specimen shows a well-circumscribed encapsulated mass measuring 2.7x2.8 cm size, involving the lower pole. The mass revealed areas of myxoid change necrosis, and cystic change.


Microscopic findings. (A) The low power appearance demonstrating a capsule of dense collagenous fibrous tissue and myxoid zone and inflammation with cellular zone consisting of spindle cells arranged in fascicles.


Microscopic findings. (B) The area of myofibroblastic proliferation showing densely cellular fascicles.


Microscopic findings. The tumor cells were potive for smooth muscle actin.


Microscopic findings. And vimentin.


CT before therapy.


CT after 8 weeks of therapy.


MRI 4 months after start of therapy Arrows show tumor manifestation.


(a) Clinical picture showing swelling of knee joint.


(b) per-operative image showing yellow-colored hyperplastic synovium thrown in finger-like projections.


(a) X-ray showing a lytic lesion in the proximal tibial epiphysis with peripherally placed sclerotic areas.


(b) Magnetic resonance imaging of the knee joint showing a heterogeneous lesion in the tibial epiphysis, synovium having villous architecture, and same signal intensity as that of fat.


Brain fluid attenuated inversion recovery imaging performed before surgery showing a diffuse hyperintense signal within the medial temporal lobes and extending into the basal ganglia, frontal basal lobes, and leptomeninges (A).


Avid and homogeneous enhancement was noted after administration of contrast medium (B).


Brain fluid attenuated inversion recovery imaging performed after surgery depicting remarkable decreases in the extension and signal intensity within the medial region of both temporal lobes. Secondary mesial atrophy with temporal horn dilatation can be observed (A).


Brain fluid attenuated inversion recovery imaging performed after surgery depicting remarkable decreases in the extension and signal intensity within the medial region of both temporal lobes. No enhancement was observed after gadolinium injection (B).


Imaging manifestations of treatment.


(a) MRI brain with contrast demonstrated 4.7 cm multiloculated rim enhancing cystic lesion with additional smaller projections invading the right frontal lobe with associated vasogenic edema and midline shift.


(b) MRI brain with contrast demonstrating resection of right frontal mass with expected postoperative changes.


(c) MRI brain with contrast demonstrating enhancing foci within left frontal lobe adjacent to prior surgical cavity.