Enhanced CT. . Notes: This enhanced CT shows a 13 cm right renal tumor that invades the pancreas (arrows), duodenum (arrowheads), and inferior vena cava (asterisk). The second part of the duodenum shows stenosis because of the protruding right renal tumor. . Abbreviation: CT, computed tomography.


PET scan. . Notes: Scan shows accumulation of FDG in the right renal tumor (arrows). Maximum SVU is >40. . Abbreviations: PET, positron emission tomography; FDG, fluorine-18-deoxyglucose; SUV, standardized uptake value.


Esophagogastroduodenoscopy image. . Note: Esophagogastroduodenoscopy reveals a red sessile tumor protruding into the second part of the duodenum (arrows), corresponding to the findings of CT (Figure 1). . Abbreviation: CT, computed tomography.


Enhanced CT at 5 weeks after starting treatment with axitinib. . Notes: Tumor degeneration is observed (black triangle). The lumen of the second part of the duodenum (arrowheads) is wider, due to tumor shrinkage compared with the pretreatment state. Three arrows show the head of the pancreas, and the asterisk shows inferior vena cava. . Abbreviation: CT, computed tomography.


Macroscopic view of resected tissue. . Notes: (A) Shows necrotic tissue.


Macroscopic view of resected tissue. (B) Shows sarcomatoid tissue invading pancreas (arrows).


Changes in right visual acuity and frequency of ocular attacks during treatment. . Notes: Visual acuity remained at 1.0, and no ocular attacks occurred after switching to adalimumab. Black arrowheads indicate the timing of ocular attacks. *The frequency of attacks was converted into an annual frequency. Data in parentheses indicates the actual frequency of attacks during representative treatments.


(bottom) CT shows a large mass that occupies the entire true pelvis. The rectum is markedly compressed. An arrow marks a separate sarcoma nodule at the dome of the bladder.


(top) CT shows a multilobulated mass greater on the left than the right. It is immediately adjacent to pelvic peritoneum on the right and covers the rectosigmoid junction on the left. It pushes the uterus superiorly.


Left arm, antecubital area, discrete, multiple well-demarcated, edematous, erythematous papules and plaques.


Face, frontal view. Leonine facies: Diffuse skin infiltration, multiple nodular lesions.


Histopathology, skin biopsy, taken from left arm. H&E staining 200 x magnification showing non-caseating granulomatous dermatitis.


Trends in WBC, serum creatinine, and albumin-corrected calcium over 10 hospital days. There is sustained improvement in WBC, creatinine, and calcium levels after administration of oral prednisone, as noted on hospital day 6.


16 contact lead spinal cord stimulator trial placed in the T8-T9 epidural space.


Lateral thoracic X-ray image showing permanent paddle lead placement in the thoracic interspaces.


Brain magnetic resonance image showing leptomeningeal/periventricular enhancement, but no mass lesion.


Actively dividing primary effusion lymphoma cells (DQ stain; original magnification x600).


Cytospin showing LNA-1 (human herpesvirus-8) positive tumor cells (immunocytochemistry; x400).


Flow cytometric analysis showing that large lymphocytes (red), 2.1% of the total population, were (a) CD20 negative, CD19 dim positive, and (b) CD38 positive (blue: B-cells, grey: Other lymphoid cells including T-cells and NK-cells).


Preoperative physical examination. The swelling was elastic and hard. There was no scar and no central punctum.


Intraoperative photograph (arrow: antebrachial interosseous membrane). The cystic mass was covered by a thick white capsule and its bottom was adjacent to the antebrachial interosseous membrane. There was no scarring around the fascia.


Histopathological findings (hematoxylin-eosin staining, original magnification x 100) upper arrow: squamous epithelium lining, lower arrow: keratin collections. The cyst wall was composed of stratified squamous epithelium with abundant keratin. There were no hair tissue structures or atypical cells.


Necrotic tissues of the patient in case report 2.


For the patient in the second case report, most of the scrotal skin and all of the penis skin were removed; this externalized the testes, epididymides, and cavernosa corpora.


Smears from breast mass showing abundant mucin and monomorphic large cells with eccentric nuclei (Pap, x400).


Chest radiography showed a cardiothoracic ratio of 66 % with cardiac enlargement and bilateral pleural effusions, which were greater on the right. Lung lesions were not clearly visible.


Contrast-enhanced chest computed tomography scan confirmed the ultrasound findings and showed mass effect on the superior vena cava, which was significantly narrowed. The inside of the tumor could not be clearly visualized on contrast-enhanced imaging; neither fatty nor calcified components were observed.


Microscopic examination of hematoxylin and eosin-stained slides of the tumor specimen showed no pattern or any specific tissue architecture at low magnification (A), indicating an undifferentiated malignant tumor.


In addition, highly deformed nuclei were found on high magnification (B).


Immunostaining was positive for vimentin (C).


Crusted VZV lesions (sacrum) and reddish-blue painful lesion on left buttock.


Chest X-Ray showing pulmonary infiltrates and cardiomegaly.


Echocardiography showing prolapse of mitral valve (arrow).


Endoscopic images of Case 1. Multiple white spots are seen in the gastric fornix.


Endoscopic images of Case 1. And body.


Endoscopic images of Case 1. Magnifying endoscopy observation.


Endoscopic images of Case 1. Blue laser imaging. Show deposition of slightly elevated, round, white substance and microvasculature on its surface, which are consistent with reported features of white globe appearance.


Pathology images of Case 1. Biopsied specimen reveals cystic dilatation of the gastric fundal gland that had a 400 mum diameter (a, b).


Pathology images of Case 1. Parietal cell protrusion is also noted. Arrows) along with dilated duct. Asterisk).


Endoscopic images of Case 2. Multiple white spots are identified in the gastric fornix. Arrows).


Endoscopic images of Case 2. Body. Post-indigo carmine spraying).


Endoscopic images of Case 2. Magnifying endocopy observation.


Endoscopic images of Case 2. Blue laser imaging. Show small, round, white deposits.


Pathology images of Case 2. The biopsied specimen shows cystic dilatation of the gastric fundal gland of approximately 600 mum diameter (a, b).


Pathology images of Case 2. Parietal cell protrusions and dilated glands forming microcysts are also seen (c).


Radiographic findings. (A) CT image of the lower abdomen showing a poorly delineated, partially necrotic tumor in the ileocecal region with a maximum diameter of 9.6 cm.


Radiographic findings. (B) CT scan of the upper abdomen demonstrating hepatic metastases in segments II, VII, and VIII with a maximum diameter of 2.6 cm (segment VI not visible in this image plane).


Radiographic findings. (C) Follow-up examination 24 months later showing subtotal regression of the metastases in segments VII and VIII and total regression of the lesion in segment II.


Clinical photograph of the patient did not reveal any facial asymmetry.


Orthopantomogram showing radiolucent lesion involving left mandibular ramus (white arrow head) with fine septations and soap bubble appearance.


Noncontrast bone window settings showing expansile lytic lesion with cortical thinning involving the left mandibular ramus.


Sagittal reconstructed computed tomography image showing tortuous arterial feeders (yellow arrow) from left external carotid artery supplying the enhancing mandibular arteriovenous malformation (AVM; white arrow).


CT angiography axial image showing arterial feeders (yellow arrow) from external carotid and tortuous venous channels associated with enhancing AVM (white arrow).


Axial chest contrast-enhanced CT image showing the largest detected axillary lymph node measuring 4 cm in its greatest dimension (arrow).


Light microscopy appearance of an excised lymph node transverse section showing altered general architecture due to presence of lymphoid cells of variable size and irregular shape arranged in follicle-like groups with lymphoid proliferation centers (arrowheads) and pseudogranulomas (arrows) (hematoxylin-eosin staining, 100 x).


Histopathologic findings in a lymph node consistent with specific granulomatous inflammation: pseudogranuloma (asterisk) with homogeneous structure surrounded by lymphohistiocytic infiltration (arrow) and a forming connective tissue pseudocapsule (arrowhead) (hematoxylin-eosin staining, 200 x).


A; An illustration of the supernumerary motor phantom limb (SPL) drawn by the patient himself.


B; An illustration of the SPL drawn by the therapist according to the patient's statement.


Clinical intraoral image of the exophytic lesion in relation to lingual area.


Clinical intraoral image. The lesion was pedunculated involving the lingual mucogingival line and inserted on the keratinized mucosa.


Fundus image of the right eye showing pars plana cyst temporally from 8:30' to 9:30'.


Fundus image of the left eye showing pars plana cyst temporally from 2:30' to 3:30'.


Response to treatment. Primary tumor in the left lower lobe. Complete metabolic response to crizotinib as indicated by 18F-FDG-PET/CT scans before.


Response to treatment. Primary tumor in the left lower lobe. And after 4.5 months of treatment.


Response to treatment. Primary tumor in the left lower lobe. Partial response according to RECIST 1.1 criteria: tumor shrinkage from 33 to 13 mm before.


Response to treatment. Primary tumor in the left lower lobe. And after 4.5 months of crizotinib.


FNAC smear showing microfilaria in the background of degenerated inflammatory cells (Giemsa, x100).


Echocardiogram performed on the first day in hospital. A movable mass (large white arrow, 23.7mmx14.9mm) can be seen on the anterior mitral leaflet (small white arrow), and this caused the valve annulus to adhere to the valve leaflet.


(A) Sagittal FLAIR MRI sequence showing cerebral atrophy with a frontotemporal predilection and post-ischemic hyperinsities in the white matter.


(B) Axial FLAIR MRI sequence showing asymmetry of frontotemporal atrophy with left-side predominance. FLAIR, fluid-attenuated inversion recovery; MRI, magnetic resonance imaging.


Macroscopic and microscopic findings of histopathological examination of brain tissue. (A) Diffuse brain atrophy with the compensatory dilatation of the lateral and third ventricles; the atrophy was most pronounced in the frontotemporal regions, particularly in medial temporal lobes.


Macroscopic and microscopic findings of histopathological examination of brain tissue. (B) Lewy bodies in the neurons of the amygdala (HandE, magnification 400x).


Macroscopic and microscopic findings of histopathological examination of brain tissue. (C) Lewy bodies, dystrophic Lewy neurites and dots in the amygdala (alpha-syn 5G4, magnification 200x).


Macroscopic and microscopic findings of histopathological examination of brain tissue. (D) Neurofibrillary tangles and threads in the hippocampus (AT8, magnification 200x).


Macroscopic and microscopic findings of histopathological examination of brain tissue. (E) beta-amyloid deposits in the hippocampus (beta-amyloid, magnification 200x).


Macroscopic and microscopic findings of histopathological examination of brain tissue. (F) Plaques in the frontal cortex (AgNOR, magnification 100x).


Lesion surgical enucleation and extraction of tooth 26.


Specimen for histopathological analysis tooth 26.


(a) Histological features of the biopsy specimen showing cellular connective tissue and presence of multiple islands and strands of odontogenic epithelium (Hematoxylin-eosin stain; original magnification x400).


(b) Immunohistochemical reaction for AE1/AE3 : positive staining for odontogenic epithelium (original magnification x400).


The figure shows a TEE long axis view of the aortavalve and ascending aorta. The arrow denotes the vegetation on the bicuspid valve.


Interdigital pilonidal sinus of the right hand third web space.


(a) Histological examination in the first patient revealed a sinus tract, and multiple broken hair shafts. The sinus was surrounded by benign squamous epithelium, acute, and chronic inflammatory cells with foreign body giant cells. X40), (b) Histological examination in the second patient showed a sinus tract with multiple broken hair shafts, and . Foreign body type granulomas. X40).


Ultrasound of the left breast centered on the palpable lump showing an oval, heterogeneous lesions with smooth borders.


MRI showing the mass on the left breast with lobulated appearances. On T2-weighted MR image with fat saturation (A), the lesion demonstrates a heterogeneous appearance with areas of low and high signal.


MRI showing the mass on the left breast with lobulated appearances. On T1-weighted MR image (B), the lesion shows a more homogeneous appearance with a hyposignal.


MRI showing the mass on the left breast with lobulated appearances. On T1-weighted MR image with gadolinium and fat saturation (C), the mass demonstrates a heterogeneous enhancement, with a polylobulated appearance. No lymphadenopathies are seen.


Extraoral swelling.


Intraoperatively showing two cystic swellings delivered via the submandibular approach.


Specimen measuring 3 cm x 2 cm.


Cheesy material inside the swelling.


Histopathological slides.


MRI of bilateral breast lumps- 3.8 x 3.5 x 3 cm irregular speculated mass in left breast (Suspicious of malignancy), 2.3 x 1.5 cm well defined mass lesion in right breast (less than 6% malignant probability).


Benign ductal epithelial cell cluster (Pap, x100).


Lesion with bare bipolar nuclei in the background (MGG, x400).


Medical image.


Clusters of cells with hyperchromatic nuclei and prominent nucleoli (MGG, x400).


Digital X-ray KUB showed a large soft tissue density in right lumbar region with loss of right psoas shadow, blurring of preperitoneal fat planes, displaced bowel loops and mild scoliosis of spine.


Fine needle aspirate smear shows lipid laden macrophages and few haemosiderin laden macrophages consistent with the diagnosis of Xanthogranulomatous pyelonephritis (Haematoxylin and eosin; x40).


(a) Computed tomography (CT) head (axial view).


(b) CT head (sagittal view).


(c) Magnetic resonance imaging (MRI) brain (coronal view).


(d) MRI brain (sagittal view).


(e) MRI brain (axial view).


A pre-operative electrocardiogram showed sinus rhythm with a heart rate of 75 beats per minute and p mitrale (noted by the negative q wave deflection of more than 1 mm in the lead V1, suggestive of left atrial enlargement).


Axial CT Scan of Left Lower Extremity. Arrowhead demonstrates discrete intramuscular fluid collection with the largest focus centered in the vastus lateralis.


Coronal CT Scan of Left Lower Extremity. Arrowhead demonstrates discrete intramuscular fluid collection with the largest focus centered in the vastus lateralis.


Lumbar computed tomography scan: hyperdense lesion, suggestive of a calcified tumor.


Intraoperative image: intradural calcified lesion.


Transversal section of the abdominal CT scan revealed an inhomogeneous round tumor of 73 x 61 mm with sharp margins and with hypodense fatty components and enhancing soft tissue.


Laparotomy showed a 10-cm-large tumor, which was completely resected.


Histological section with HE staining of the resected myofibroblastic tumor showing spindle cell proliferation, fibrotic lymph node involvement and central necrosis. Magnification x5,000.


The axial T2WI image shows a small strip of a hypersignal lesion near the left lateral ventricle (A).


The lesion presented hyperintensity on FLAIR.


No significant diffuse obstruction on DWI.


No significant enhancement (D) was observed in the GD-DTPA enhanced sequence.


Preoperative intraoral findings. . A: Upper dentition (occlusal view).


Preoperative intraoral findings. . B: Lower dentition (occlusal view).


Preoperative intraoral findings. . C: Front teeth (front view).


Preoperative intraoral findings. . D: Left-side view of molar occlusal status. Planned implant site indicated with an asterisk.


Preoperative radiographic findings. . A: Periapical radiographof the planned implant site. Arrowheads indicate the borders of an irregularly-shaped radiolucency.


Preoperative radiographic findings. . B: Panoramic radiograph, with an irregularly-shaped radiolucency (arrowheads) also visible.


3D-microCT images of the alveolar biopsy sample. . Left to right: microCT images, with the sample being successively rotated approx. 60 degrees clockwise each time. . CB: cortical bone; TB: plate-like trabeculae.


Microphotograph showing cohesive clusters of oncocytes with granular, eosinophilic cytoplasm and central pyknotic nuclei in a clear background (1a: MGG,x400; 1b: H and E, x400).


Post contrast sagittal image of lumbo sacral spine showing a cystic lesion at D12-L1 level with enhancement of cyst wall.


T2W sagittal image of spine showing a hyperintense cystic lesion at D12 - L1 level with hypointense cyst wall.


Intra-operative image after performing laminectomy at D12- L1 level. The lesion appears predominantly cystic but the walls are densely adherent to the surrounding nerve rootlets.


Histopathology image of cyst wall showing pseudostratified lining with goblet cells.


Cilia.


Cytologic smears. (A) Isolated mononucleated and binucleated cells, some with cytoplasmic granules (Wright stain, x400).


Cytologic smears. (B) Amyloid-like materials (Wright stain, x400).


Cytologic smears. Round cells with multiple Auer rods in the cytoplasm (arrow). Wright stain, x400.


Cytologic smears. . Wright stain, x1000).


Histologic section. Sheets of neoplastic cells with stippled chromatin and amyloid deposition (H&E stain, x400).


(a) MRI showed the rectovaginal fistula before administration of infliximab. (b) Barium-enema study showed the barium running into the vaginal cavity before administration of infliximab. White arrows pointed respectively A: rectum;. Rectovaginal fistula.


(a) MRI showed the rectovaginal fistula before administration of infliximab. (b) Barium-enema study showed the barium running into the vaginal cavity before administration of infliximab. . Vagina cavity.


Symptomatic changes (excrement time, CRP, BMI, ERS) after admission in a graph with time dependently as a basic date (day 0) by the infliximab beginning day.


(a) MRI.


(b) Barium-enema study. Both examinations are inspected from the start of therapy 1 year later, and confirmed rectovaginal fistula closing.


Red free fundus photos (a, b) of Case 2 (mother of Case 1) demonstrating bilateral angioid streaks (thick green arrows) and fibrotic disciform scars (purple triangles).


Indocyanine green angiography (c, d) demonstrates polyp lesions at the edge of the disciform scars in the right eye (yellow arrow) and late geographic hypercyanescence in the left eye (red triangle) demonstrating the appearance of a branching vascular network, consistent with a diagnosis of advanced polypoidal choroidal vasculopathy.


Postoperative sagittal T2 magnetic resonance imaging of the lumbar spine demonstrating postoperative changes of laminectomy with residual intradural lesions at L1. This was the only postoperative image obtained as patient discomfort led to an early terminated examination.


Gross photograph of a congenital giant nevus.


Preoperative photograph of the nodular lesion in the penis.


Microscopic pathology of a surgical specimen at 40 x magnification.


Microscopic pathology of a surgical specimen at 400 x magnification.


Xiao Shi, MD.


Multilocular thymic cyst with follicular hyperplasia in a 47- year-old HIV+ female with cough and chest pain. Postero-anterior chest radiograph demonstrates an abnormal contour along the right cardiomediastinal border (arrow).


Multilocular thymic cyst with follicular hyperplasia in a 47 year-old HIV+ female with an anterior mediastinal mass. Axial contrast enhanced chest CT at the level of the heart shows a 7.1 x 2.7 x 8.8 cm lobular lowattenuation mass with heterogeneous enhancement draped across the anterior mediastinum (arrow).


Multilocular thymic cyst with follicular hyperplasia in a 47 year-old HIV+ female with an anterior mediastinal mass. Coronal contrast enhanced chest CT shows low-attenuation cystic areas and enhancing septations (arrow).


Multilocular thymic cyst with follicular hyperplasia. Gross thymectomy specimen from a 47- year-old HIV+ female weighs 180 gram and measures 14.5 cm from medial to lateral, 15 cm from superior to inferior and up to 3.5 cm from anterior to posterior. The gland is very lobulated in appearance with a moderate amount of attached adipose tissue. The gland appears encapsulated with a smooth and glistening pink-purple surface.


CT of metastatic disease. Axial CT of the abdomen and thorax. Multiple contrast-enhancing lesions in the liver with irregular borders typical for metastases (a). Histopathological analysis of a liver metastasis revealed only large, pleomorphic cells (a inset) consistent with a highly malignant dedifferentiated pleomorphic sarcoma. CT of thorax showing multiple round, well-circumscribed lung lesions consistent with metastases.


CT of metastatic disease. Axial CT of the abdomen and thorax. The ground-glass opacity around the lesions may be caused by hemorrhage (b).


CT showing radiological response. Axial CT of the thorax and abdomen showing almost complete radiological response after histological subtype-specific chemotherapy. A small metastatic lesion measuring 5 x 6 mm. Arrow).


CT showing radiological response. Axial CT of the thorax and abdomen showing almost complete radiological response after histological subtype-specific chemotherapy. No other visible metastatic foci in the lungs or the liver. Are seen after chemotherapy.


CT images of the abdomen with contrast medium shows a heterogeneously enhancing exophytic mass projecting posteriorly from the upper pole of the right kidney.


MR images with contrast showed a 4-cm complex enhancing mass at the projecting from the posterolateral aspect of the upper pole (indicating arrows) of the right kidney; the complex mass demonstrated heterogeneous signal internally including a focal hypointense signal on precontrastT1 weighted sequences; and these areas also showed hyperintense signal postcontrast suggesting hemorrhage, necrosis, and scar formation components.


F-18 FDG PET images.


Tumor is composed of clear cells.


Clinical and treatment parameters of the patient during the 1st month after hospital admission. (A-H) show the time course of different laboratory parameters during the first 30 days following hospital admission.


Clinical and treatment parameters of the patient during the 1st month after hospital admission. (I) displays a timeline of the different clinical parameters and specific therapy during the first 30 days.


Histopathology and immunohistochemistry of the patient's endomyocardial biopsy. Serial tissue sections of paraffin-embedded endomyocardial biopsies reveal perivascular fibrosis in absence of myocyte necrosis [Masson Trichrome.


Histopathology and immunohistochemistry of the patient's endomyocardial biopsy. HE. Stainings, see circle.


Histopathology and immunohistochemistry of the patient's endomyocardial biopsy. Severe infiltration of CD68+ macrophages.


Histopathology and immunohistochemistry of the patient's endomyocardial biopsy. CD3+ T cells. Primarily around intracardiac small vessels (see circle, magnification x200). HE, hematoxylin-eosin; CD, cluster of differentiation.


(a) A well-defined extra-axial lesion is identified anterior to the brainstem on this sagittal view, appearing hyper intense relative to brain parenchyma on the T2 weighted image (White arrows).


(b) Similar section noted one year later with reduction in mass of the cystic lesion identified in the image a.


(a) T1 weighted Brain MRI, this axial section identifies the lesion anterior to the brain stem appearing hyper intense relative to brain parenchyma (White arrows).


(a) T1 weighted image with contrast Brain MRI, this axial section identifies the lesion anterior to the brain stem appearing hyper intense relative to brain parenchyma with no enhancement noticed on contrast (White arrows).


Clinical photograph showing irregular, nodular, and discolored lesions on the forearm.


Clinical photograph showing erythematous, nodular, irregular lesions on the anterior chest wall, below the left nipple.


X-ray chest Posteroanterior view showing irregular diffuse deposition of mercury in the subcutaneous plane.


Gross photograph showing tissue bits with some shiny material on cut surface.


(a,b) Coronal and Saggital sections from CT Skeletal survey for paraproteinaemia. Single 3.2 x 1.5 cm medium low attenuation lesion with a thin sclerotic margin in the midshaft of the right femur causing mild scalloping of the adjacent inner aspect of the medial cortex.


MRI with standard multi-planar technique. (a, b) Coronal and sagittal T2 weighted MRI images of a 1.4 x 2.0 x 3.3 cm showed a hyperintense, well marginated, eccentrically located and marginally expansile lesion involving the mid right femoral shaft.


MRI with standard multi-planar technique. (c) Coronal T1-weighted image showed a well circumscribed cystic lesion of the right femoral shaft with a narrow zone of transition. It was fluid filled and has a relatively homogenous consistency with no cortical expansion. No other focal lesion seen.


(a,b) Femur XR post-operatively. The Intramedullary nail in situ in satisfactory position with evidence of excision biopsy site and cortical erosion.


(a) Low power image showed a fragmented spindle cell lesion and accellular necrotic bone.


(b) High power image showed biphasic appearance with hypercellular Antoni A areas and myxoid hypocellular Antoni B areas. There was evidence of nuclear pallisading around fibrillary processes (verocay bodies) and variable cellular spindle cell proliferation consistent with schwannoma. No atypical infiltrate or evidence of malignancy was seen.


(c) Cytoplasmic and nuclear immunohistochemical staining demontrated that the neoplastic cells are positive for S100.


The timeline showing the history of treatment and examinations for the patient under current study.


Family pedigrees case 1. The arrow point to the proband case who underwent whole-genome sequencing.


Summarizing scheme of disease progress.


Bone marrow smears of an acute myeloid leukemia without maturation case showing numerous blasts with round nuclei, fine nuclear chromatin, and dark blue cytoplasm (Leishman stain, oil immersion x 100).


GTG-banding in secondary AML-M6 revealed a tetraploid karyotype in 20% of the analyzed cells.


Ultrasound image of involved lymph nodes.


Fused positron emission tomography-fluorodeoxyglucose (PET-FDG) image before AVD treatment.


HE (magnification 400x).


HE (magnification 100x).


Immunohistochemical staining CD30 (magnification 400x). The stains included anti-CD20, CD3, CD30, CD15, PAX5, MUM-1, Ki-67.


HE immunohistochemical staining (magnification 400x). The stains included anti-CD20, CD3, CD30, CD15, PAX5, MUM-1, Ki-67.


Intraoral view showing the absence of 11.


Preoperative maxillary occlusal radiograph revealing impacted 11 and multiple supernumerary teeth.


Surgical area after removal of supernumerary teeth.


Surgically removed supernumerary teeth and soft tissue mass.


Panoramic radiograph showing Begg's bracket on 11 and traction with a ligature wire tied to a stainless steel base arch wire.


Intraoral view showing the alignment of 11 and a rectangular stainless steel wire.


Post- treatment intraoral view showing well aligned 11.


Preoperative panoramic radiograph showing impacted 11 and supernumerary tooth.


Panoramic radiograph showing mild eruption of 11.


Surgical exposure of 11.


Intraoral view showing the alignment of 11 with a NiTi wire.


Intraoral view showing the complete alignment of 11.


Left lower leg of case 1 on day 14 of hospitalization.


Left lower leg of case 1 on day 68 of hospitalization.


Female patient aged 45 years with POF in mandibular anterior region, displacing central, lateral and canine teeth.


Microscopic picture of biopsy slide showing- proliferated fibrous bands in the connective tissue with uniformly distributed chronic inflammatory cells.


Micro-photograph of another specimen of the same biopsy, showing thick fibrous whirls.


Multiple foci of osteoid tissue, surrounded by fibrous whirls.


Sam slide at further location showing multiple foci of osteoid tissue, surrounded by fibrous bands.


Molecular cytogenetic characterization of the marker chromosome. Arrows indicate the marker chromosome. (A) Spectral karyotyping.


Molecular cytogenetic characterization of the marker chromosome. Arrows indicate the marker chromosome. (B) Whole chromosome paint 18 green.


Molecular cytogenetic characterization of the marker chromosome. Arrows indicate the marker chromosome. (C) chromosome 18 arm-specific painting, 18p green/18q red.


Molecular cytogenetic characterization of the marker chromosome. Arrows indicate the marker chromosome. (D) Multicolor DNA Probe Kit CEP 18 aqua/X green/Y orange.


Electropherogram of the unbalanced marker D18S386 on chromosome 18.


(A) On admission.


(B) Two weeks after treatment.


(A) IgG staining.


(B) IgG4 staining.


PET-CT showed high glucose intake in salivary glands, lymph nodes, liver, and spleen.


Dynamic changes of laboratory examination. (A) WBC, NE underwent significant reduction after taking meropenem and TMP-SMX.


Dynamic changes of laboratory examination. (B) CRP, PCT underwent significant reduction after taking meropenem and TMP-SMX.


Dynamic changes of laboratory examination. (C) Renal glomerular function improved with lower urinary protein/24h urinary protein quantification.


Dynamic changes of laboratory examination. (D) Renal function retaining almost steady on the creatinine, eGFR, urea.


Routine bacterial culture result, identification of bronchoscopy specimens: Nocardia (Magnifications: 100x). (A) yellowish bacterial colony growing after bronchoscopy specimen inoculated on the culture medium.


Routine bacterial culture result, identification of bronchoscopy specimens: Nocardia (Magnifications: 100x). (B and C) Gram-positive, partial acid-fast positive, rod-shaped bacterium.


DWI: Patchy diffusion restricted lesions with high signal in the left frontal lobe, the corresponding ADC diagram shows uneven low signal changes.


The clinical course of this case.


Single-cell analysis of resected tissue from enhancing and non-enhancing lesions (A) Uniform Manifold Approximation and Projection (UMAP) representation of ten identified cell types in enhancing and non-enhancing samples from the resected tissue.


(B) Percentages of each cell type of all cell populations.


Subclustering analysis of T and NK cells. (A) UMAP plot showing three distinct T cell subpopulations, CD4+, CD8+, and Tregs (CD4+/FOXP3.


Subclustering analysis of T and NK cells. (B) UMAP representation of cytolytic score of T cells.


Subclustering analysis of T and NK cells. (C) Violin plots summarizing the cytolytic score of NK cells and T cells from enhancing and non-enhancing samples. The average cytolytic scores of T cells were 1.87 in enhancing and 2.50 in non-enhancing lesions (Wilcoxon test p = 3.084 x 10-6), and the average cytolytic scores of NK cells were 3.06 in enhancing and 4.66 in non-enhancing (Wilcoxon test p = 4.136 x 10-14).


Tumor cells arranged in papillary configuration (Pap, x200).


Papillary fragments revealing round to oval cells with hyper-chromatic nuclei and prominent nucleoli and abundant vacuolated cytoplasm (Pap, x400).


Clusters and papillary fragments of atypical cells containing abundant cytoplasm. (MGG, x200). Extracellular hyaline material (MGG, x100 [Inset]).


Changes of inflammatory markers during antibiotics treatment ( CRP.


Medical image.


WBC).


Computed tomography scan showing lytic lesion in mandible.


Fine-needle aspiration cytology smears showing many multinucleate giant cells (Leishman, x400).


Fine-needle aspiration cytology smears showing multinucleate giant cells amidst hemorrhagic background (Papanicolaou, x400).


Histopathology of parathyroid adenoma (x400).


Blue-gray colored eye lid with underlying tissue necrosis.


Intraoperative appearance of advancing wound.


Extraoral photograph of patient.


Clinical photograph showing. Gingival swelling on palatal aspect of 54.55.


64.65. Diffused.


Erythematous ulcerated gingival swelling covered with necrotic slough over buccal aspect of 64.65.


Gingival swelling with tiny bleeding spots over buccal aspect of 75 and 85.


(a and b) Intraoral radiograph showing radiolucent lesion surrounding root of 55, 74 and 75.


Orthopantomogram revealed multiple areas of bone loss in the left mandibular region.


(a and b) Axial and coronal computed tomography revealed multiple soft tissue density lesions with irregular and punched out bony destruction noted involving left mandibular, left side of occiput, right maxillary and right temporal bone.


Three-dimensional computed tomography revealed multiple osteolytic lesions in relation to maxillary alveolar process, body and ramus of left side of mandible.


Histopathological picture showing diffuse infiltrate of Langerhans cell with eosinophils (H&E stain, x40).


Trichoscopy presentation of hair roots.


Preoperative computerized tomography scan revealed an osteolytic multilocular radiolucency at posterior mandible associated with an impacted developing tooth.


A photomicrograph of Hematoxylin and eosin (H&E) stained sections showing primitive connective tissue stroma covered by columnar epithelium,. X100).


Follow up Computerized tomography scan revealed a new spongy bone formation at the site of preexisting lesion.


F; Computed tomography of the chest showing multiple random nodules diffusely distributed in both the lung fields.


MRI post-shunting (20 days). (A) MRI (T1-weighted image) shows a hypointensity signal periaqueductal area (red circle) with irregular profile suggesting the presence of the lesion.


MRI post-shunting (20 days). (B) MRI scan (T2-weighted image) shows a hyperintensity signal in the same area (red circle).


MRI post-shunting (20 days). (C) Gadolinium T1-weighted image shows a low focal contrast enhancement of the lesion in the periaqueductal area.


MRI post-shunting (20 days). (D) Proton magnetic resonance spectroscopy (MRS) reveals elevated cholin peaks (cholin/creatinine ratio at 1,9) in addition to reduced NAA (N-acetylaspartate).


MRI post-shunting (20 days). (E) Perfusion-weighted imaging (PWI) shows a low cerebral blood volume (CBV) in the area of interest.


A 76-year-old male who presented with an enlarging right breast lump which proved to be an epidermoid cyst. Gray scale ultrasound of the right breast demonstrates an oval circumscribed mass with heterogeneous echogenicity at the 12 o'clock position 4 cm from the nipple. The mass is primarily located within the subcutaneous tissue. Contact with the deepest dermal layer forms an obtuse angle.


A 76-year-old male who presented with an enlarging right breast lump which proved to be an epidermoid cyst. Color Doppler ultrasound of the right breast mass demonstrates internal vascularity (arrow).


A 76-year-old male who presented with an enlarging right breast lump which proved to be an epidermoid cyst. Ultrasound- guided core biopsy of the right breast mass was performed with a 12-gauge needle.


A 76-year-old male who presented with an enlarging right breast lump which proved to be an epidermoid cyst. Post-biopsy ultrasound of the right breast mass 2-3 weeks later demonstrates a ruptured epidermoid cyst with surrounding inflammation and abscess formation. Note pus-filled tract extending to the skin (arrow).


Histopathological image shows sheets of odontogenic epithelium in the stroma arranged in cords and small islands (H&E,x100).


Histopathological image shows sheets of odontogenic cells with hyperchromatic nuclei and prominent intercellular bridges H&E x400).


Histopathological image shows nests of clear cells (H&E x400).


Histopathological image shows amyloid-like material admixed with epithelium (Congo red, x100).


2-Dimensional echocardiographic imaging (apical 4 chamber view) demonstrating dilated right side of the heart with most of the right ventricular cavity occupied by the tumor mass.


2D apical 4 chamber view showing forward tricuspid flow through the residual RV cavity.


Representative picture showing results from three independent endoscopic evaluations of the intestine of the patient obtained at different times before he was started on antibiotic therapy. There was no opportunity for further evaluations during treatment.


(A) Heavy shedding of typical MAP bacilli as seen in ZN staining: 4+ (positive).


(B) Negative for MAP bacilli at the end of 12 months of treatment.


Cat toy.


Granulomatous response to synthetic fibers.


Synthetic fibers with polarized light.


Clinical photographs. . Notes: (A) Patient's clinical presentation of herpes zoster ophthalmicus in 2002 (inset) with a slit-lamp photograph of his neurotrophic corneal ulcer in 2007.


Clinical photographs. (B) Cyanoacrylate glue had been applied for the management of a perforated corneal descemetocele in April 2011.


Clinical photographs. (C) Suspected vitreous prolapse from previous cataract surgery or accumulated fibrin that may have allowed passage of mycobacterial past the lens implant into the vitreous cavity (inset), and recurrent hypopyon.


Clinical photographs. (D) Clear corneal graft and anterior chamber 1 month after the pars plana vitrectomy, anterior chamber washout, and intravitreal injections of antimicrobial and fungal agents (amikacin, 400 mug/0.1 mL; vancomycin, 1 mg/0.1 mL; and amphotericin B, 5 mug/0.1 mL).


Squash smear showing tigroid background and dual population of cells; large polygonal tumor cells with vesicular chromatin, moderate amount of fragile vacuolated cytoplasm (arrow head) and mature lymphocytes in the background (arrow) (May Grundwald Giemsa X400).


Chest X-ray upon first admission. . Cardio-mediastinal silhouette is within normal limits with the heart being normal in size. . No pleural effusion / pneumothorax/consolidative patches identified.


Chest X-ray upon his most recent admission. . Mildly prominent hilar vascular markings identified (red arrows) with minimal blunting of the left costophrenic angle (blue arrows) and mild elevation of the left hemidiaphragm. But Cardio-mediastinal silhouette.


Chest CT upon recent admission. . Congestive pulmonary changes in the form of ground glass opacities and pleural effusion at the posterior inferior aspects of both lungs, more on the left. (Arrow heads) Circumferential pericardial effusion (red arrow).


Pleural and Pericardial Biopsy Histopathology report. . A. Light microscopic view showing well-defined epithelioid granuloma engulfing parasitic egg (H&E x400).


Pleural and Pericardial Biopsy Histopathology report. . B. The cuticle of the parasitic egg is polarizable (H&E x400 with polarizer/analyzer lens).


CT imaging of the maxillofacial region shows a heterogeneous mass over the left side of the nasal dorsum and frontal process of the left maxilla.


Photomicrograph showing acellular material arranged as nodules (Congo red, 20x).


Cytogenetic result of unstimulated bone marrow samples showing 47,XX, +4, t(8;21) in all metaphase plates.


(A) A metaphase cell following FISH with LSI AML-ETO (Abbott Molecular, USA).


(B) Whole chromosome paint probe 4 with spectrum Orange (Abbott Molecular, USA).


Magnetic resonance imaging (MRI) study of head and neck. A, Axial MRI scan showing a significantly increased signal of the bone marrow lesion (yellow arrow) when compared with left mandibular body (asterisk), with bone edema indicative of an inflammatory process taking place in the right mandibular body and gas tracking along the two pterygoid muscles (white arrows).


Magnetic resonance imaging (MRI) study of head and neck. B, A coronal T2-weighted image of the submandibular region showing a wide mass with very high signal intensity from the parapharyngeal space to the inferior cervical region with associated edema.


Gynecomastia.


Almond shaped eyes with esotropia.


Fluorescence in situ hybridization.


Autopsy findings. (A) Crescentic necrotizing glomerulonephritis. , x 400.


Autopsy findings. (B) Alveolar hemorrhage with neutrophil infiltration. , x200.


Autopsy findings. (C, D) DVT: neutrophils were abundant in the thrombus. Original magnification: x40.


Autopsy findings. (C, D) DVT: neutrophils were abundant in the thrombus. , x 400.


Autopsy findings. (E-G) NETs in the glomerulus. Blue: DNA stained by DAPI. Red: MPO. NETs were present in the crescent. , x 400.


Autopsy findings. (H-J) NETs in the thrombus. The detection of NETs was performed similar to the renal specimens. , x 400.


Mutational landscape of the three renal tumors in the patient's left kidney at first recurrence. We visualized the somatic mutation profiles of each tumor:angiomyolipoma (AML), clear cell renal cell carcinoma (RCC), and papillary RCC:as heat maps (black-colored genes indicate driver gene mutations in many cancer types). CDH11, Cadherin 11; CDK12, Cyclin Dependent Kinase 12; DICER1, Dicer 1; PABPC1, Poly(A) Binding Protein Cytoplasmic 1; PARP4, Poly(ADP-Ribose) Polymerase Family Member 4; PBRM1, Polybromo 1; POLQ, DNA Polymerase Theta; PTPN13, Protein Tyrosine Phosphatase Non-Receptor Type 13; PTPRK, Protein Tyrosine Phosphatase Receptor Type K; RET, Ret Proto-Oncogene; RPS3A, Ribosomal Protein S3A; SAMD3, Sterile Alpha Motif Domain Containing 3; SMARCA1, SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 1; SUSD2, Sushi Domain Containing 2; TSC1, TSC Complex Subunit 1; ZNF208, Zinc Finger Protein 208; ZNF721, Zinc Finger Protein 721.


(a) Photomicrograph of normocellular bone marrow trephine biopsy (H and E, x40). (b) Numerous histiocytes replacing the other normal bone marrow cell constituents (H and E, x100).


Photomicrographs of immunohistochemistry revealing (a) Positive cytoplasmic immunoexpression of CD68 in histiocytes (CD68, x200).


(b) CD1a-negative histiocytes (CD1a, x200).


(c) Negative immunoexpression of histiocytes for S100 (S100, x200).


(d) CD3 immunopositive expression of the lymphocytes (CD3, x200).


(a) Periodic acid-Schiff stain negative histiocytes (PAS, x200).


(b) Perl's Prussian blue staining showing unstained brown pigment in the histiocytes (Perl's stain, x200).


(a) Schizont of P. Vivax (encircled) on peripheral blood smear examination (Leishman stain, x200). (b) Bleaching of the brown-colored pigment in the histiocytes with the alcoholic ammonium hydroxide (H and E, x200).


A set of antibiotic-loaded articulate spacers that were implanted.


T1-weighted sagittal image of a 2-year-old girl. Note the hypoplastic pons and cerebellum with normal appearance of the corpus callosum.


Healthy donor) blood CD8- TCRgammadelta- T-cells, monocytes, and dendritic cells (B). Panel (B) shows CD4 surface membrane expression levels for CD8- TCRgammadelta- T-cells, monocytes, and dendritic cells for the different anti-CD4 antibody clones tested in the patient (black histogram) compared to a representative healthy donor (gray histogram) and an isotype control (red dash line), and the staining for a negative population (CD8+ T-cells) in the patient (green line) and the healthy control (blue line). DCs, dendritic cells.


Thorax CT, It is observed that the lesion shows spiculation into the lung parenchyma in the coronal reformatted images and parenchymal window.


Torax CT, Lesion with irregular borders and containing milimetric calcified focuses in the axial mediastinal window in the right apical region of the lung.


Appearance of the lesion with a moderate FDG uptake in fusion images in PET-CT.


Specimen material of the lesion after wedge resection. Red-looking lung tissue in the lesion and its surrounding area monitored off-white-yellow in colour in total.


Clinical course of the patient. . Abbreviations: HD, high dose; DEX, dexamethsone; Cy, cyclophosphamide; FLC, free light chain; IgG, Immunoglobulin G.


Axial.


Coronal T1-contrast. Image shows contrast enhancement dural-based tumor with cystic component size 7 x 5 cm resulting in midline shift of approximately 1.6 cm and third ventricular obliteration.


Axial T2 image showing hypointense cystic component (c).


Microscopic examination revealed the proliferation of neoplastic meningothelial cells with pale eosinophilic cytoplasm forming solid nests, associated with a dense chronic inflammatory infiltrate rich in lymphocytes and some plasma cells (a) (H&E, x20).


Both tumor cells and lymphocytes are positive with vimentin (b) (x20).


Negative glial fibrillary acidic protein in tumor cells excludes the diagnosis of glioma with xanthomatous changes (c) (x40).


CD3 staining in lymphocytes dispersed between tumor cells (d) (x20).


Immediate postoperative computed tomography scan showing total removal of tumor with some certain extent of midline shift (a).


Magnetic resonance imaging axial T1-contrast scan 6 months after operation showing no recurrence (b).


Bronchial washing cytology shows bronchial epithelial cells and mixed acute and chronic inflammatory infiltrate, including numerous histiocytes. Most histiocytes were packed with many yeast-like organisms (Pap, x400) with inset showing oval to oblong in shape with central transverse septum (GMS, x1000).


Bronchoscopic biopsy shows diffuse histiocytic proliferation with organisms in submucosa. (H&E, x400).


A 53-year-old female patient with emphysematous pyelonephritis with necrotizing fasciitis presented with breathlessness, pain in left lower hemithorax and in the left lumbar region. Noncontrast axial computed tomography thorax in mediastinal window showing bilateral pleural effusion (white arrow).


A 53-year-old female patient with emphysematous pyelonephritis with necrotizing fasciitis presented with breathlessness, pain in left lower hemithorax and in the left lumbar region. Coronal high-resolution computed tomography window showing necrotizing fasciitis in the left lateral chest wall (black arrow).


A 53-year-old female patient with emphysematous pyelonephritis with necrotizing fasciitis presented with breathlessness, pain in left lower hemithorax and in the left lumbar region. Axial noncontrast computed tomography abdomen showing retroperitoneal abscess extending anterolateral to left psoas, anterior to left iliacus, extending up to left inguinal region with multiple air foci (white arrows). Multiple air foci just beneath anterior abdominal wall on either side, in intermuscular fat planes of abdominal wall muscles and in subcutaneous fat in anterior abdominal wall on the left side (curved white arrows).


A 53-year-old female patient with emphysematous pyelonephritis with necrotizing fasciitis presented with breathlessness, pain in left lower hemithorax and in the left lumbar region. Noncontrast computed tomography abdomen and pelvis. Coronal.


A 53-year-old female patient with emphysematous pyelonephritis with necrotizing fasciitis presented with breathlessness, pain in left lower hemithorax and in the left lumbar region. . Sagittal) showing left renal (white arrow) and retroperitoneal abscess with air foci (curved white arrow).


A 53-year-old female patient with emphysematous pyelonephritis with necrotizing fasciitis presented with breathlessness, pain in left lower hemithorax and in the left lumbar region. Noncontrast computed tomography thorax and abdomen with pelvis. Mediastinal window - axial.


A 53-year-old female patient with emphysematous pyelonephritis with necrotizing fasciitis presented with breathlessness, pain in left lower hemithorax and in the left lumbar region. . Coronal) showing necrotizing fasciitis in the left lateral chest wall up to left axilla (black arrow), along left lateral abdominal wall (white arrow) reaching up to perivesical fat (curved white arrow).


A 53-year-old female patient with emphysematous pyelonephritis with necrotizing fasciitis presented with breathlessness, pain in left lower hemithorax and in the left lumbar region. Noncontrast computed tomography abdomen and pelvis showing pigtail catheterization in a retroperitoneal abscess (white arrow).


MRI scan of suprapatellar aspect in January 2013.


May 2017.


Histological image showing highly vascular soft tissue mass, diagnosed histologically as capillary hemangioma.


Case 2. A; FISH analysis on metaphase and interphase with an LSI ETV6/RUNX1 ES Dual Color Translocation Probe Set (Vysis).


Case 2. B; SNP array revealed the highest level of amplification located within the RUNX1 locus.


Pretreatment study models.


Right buccal occlusion.


Left buccal occlusion.


Maxillary occlusal view. Mandibular occlusal view.


Chest CT scan reveals right lower lobe cavity.


Transaxial, coronal, and sagittal statistical parametric mapping results (p=0.05 false discovery rate) confirming the hypometabolism in the cerebellar lobes.


Magnetic resonance imaging, T1 sequences with gadolinium, sagittal view. Imaging after two previous resections. Note strong dorsal (C7/Th1 to Th5) and ventral (C6 to Th3/Th4) enhancement in the spinal canal. Artifacts due to laminoplasty material.


Chest CT results on day 1, day 7, and day 14 after admission. (A) Chest CT findings on the first day of admission revealed diffuse pneumonitis throughout the lungs.


Chest CT results on day 1, day 7, and day 14 after admission. (B) The patient's chest CT on day 7 showed a worsening of the infection (due to the severity of the disease, the patient could not hold her breath well, so the images were not clear).


Chest CT results on day 1, day 7, and day 14 after admission. (C) On the 14th day of admission, the patient's chest CT results showed slight improvement after treatment.


Dynamic changes in infection indexes and platelet counts in the patient after admission. (A, B) The neutrophil and leucocyte counts decreased significantly 7 days after admission.


Dynamic changes in infection indexes and platelet counts in the patient after admission. (C) The serum procalcitonin level continued to decline.


Dynamic changes in infection indexes and platelet counts in the patient after admission. (D) The platelet count continued to increase. Eventually, the patient's indicators returned to normal (different colors represent different medications, and the length of the lines represents the duration of treatment with the medication).


Dynamic changes in liver and kidney function in the patient after admission. After appropriate treatment, the aspartate aminotransferase.


Dynamic changes in liver and kidney function in the patient after admission. Alanine aminotransferase.


Dynamic changes in liver and kidney function in the patient after admission. Lactate dehydrogenase.


Dynamic changes in liver and kidney function in the patient after admission. Creatinine. Levels of the patient gradually returned to normal (different colors represent different medications, and the length of the lines represents the duration of treatment with the medication).


The anteroposterior pelvis graphy, determined multilobular dense nodular components in the periarticular soft tissue around the pelvis joint.


Radiographs of the right knee reveal calcified masses with lucent areas in the popliteal cavity of the knee joint.


Ultrasound of the right axillary area showing a mass with cystic degeneration.


MRI of the right axillary area involved, showing a lesion in the right axilla measuring 3.0 x 3.8 x 2.3 cm, with primary cystic component and irregular thickened wall.


Anterior segment photograph of the patient's right eye.


Cataract, a retrolental vascularized mass extending from the optic disc to the posterior lens capsule, and depression and enlargement of the optic disc in the right eye by Doppler ultrasonography.


The elongation of ciliary processes was demonstrated.


A. Calcified nodule with "egg-shell" pattern.


B. Microcalcification spots in the same nodule.


A. Macroscopically complete calcified nodule.


B. Calcified rim when cut.


Erythema rash on the front of the chest.


Swelling on the palmar aspect of the index finger.


Soft tissue swelling on the palmar aspect of the finger without any bony changes.


Cut section of the well-defined tumor with fibrofatty tissue.


Histopathological appearance showing multiple multinucleated giant cells interspersed in a stroma of histiocytes and fibrous tissue.


MRI images. MRI images (1.5 tesla): (A,B) Sagittal sections in the T1-weighted MRI images: global cerebellar atrophy with a marked enlargement of the subarachnoid space, thinning of cerebellar folds and vermis (arrow) related to diffuse cerebellar atrophy.


MRI images. (C) Axial section in the T1 sequence: cerebral white matter and ventricles without alterations.


NSD1 gene sequencing. Exon 2 sequence of the NSD1 gene (superior: normal; inferior: patient sequence) showing the deletion of adenine (blue arrow) at position 247 (c.247delA), which has an effect on the protein and generates a premature stop codon at amino acid 87 (red box).


(A) Contrast-enhanced computed tomography (CECT) shows pleural-based heterogenous hypodense mass.


(B) Baseline positron emission tomography-computed tomography shows local disease.


(C) CECT shows large abdominopelvic mass.


(D) CECT shows presacral deposit.


(A) Pleomorphic liposarcoma tumor deposit shows admixture of pleomorphic lipoblasts with epithelioid cells (hematoxylin and eosin, x100).


(B) Pleomorphic liposarcoma tumor deposit shows multivacuolated lipoblasts with indented pleomorphic nuclei (hematoxylin and eosin, x200).


(C) Pleomorphic liposarcoma cells are positive for S-100 (immunohistochemistry, x200).


(D) Pleomorphic liposarcoma cells show diffuse p53 expression (immunohistochemistry, x200).


Clinial photograph showing papulovescicular lesions over the anterior chest wall (arrow).


Complete ptosis and ophthalmoplegia in the left eye.


T1 and T2-weighted MRI with gadolinium contrast of the brain and orbits. . Notes: Coronal T2-weighted MRI disclosing a 5x9x10 mm abnormal enhancing of the soft tissue in the left superior orbital fissure with mild extension along the anterior aspect of the left cavernous sinus (red arrow).


T1 and T2-weighted MRI with gadolinium contrast of the brain and orbits.an axial T1-weighted MRI disclosing mild edema of the left lateral rectus (red arrow) . Abbreviations: MRI, magnetic resonance imaging. T1, spin-lattice relaxation time; T2, spin-spin relaxation time.


Lemierre syndrome patient with neck stiffness, cervical lymphadenopathy and tenderness along the course of external jugular vein.


X-ray AP and lateral view of the neck showing increase in prevertebral shadow at 4th cervical vertebral region. Cervical lordosis is lost. Diffuse pulmonary infiltrates present.


CECT neck showing peripheral enhancing hypodense area in the prevertebral space compressing trachea and oesophagus.


Axial CECT lung window showing well-defined subpleural nodules with central cavity and feeding vessel. Minimal bilateral pleural effusion noted.


Thyroid-stimulating hormone timeline.


Bone chambers massively invaded by grayish-colored oxalate crystals deposited in stars or rosettes (hematoxylin and eosin stain, original magnification x 40).


Grayish-colored oxalate crystals deposited in stars or rosettes surrounded by a macrophage reaction against foreign bodies (hematoxylin and eosin stain, original magnification x 200).


Medullar fibrosis (special trichrome stain, original magnification x 200).


A very intense pale green birefringence of crystals of oxalate showed in polarized light (hematoxylin and eosin stain, original magnification x 400).


First CT scans at admission. Acute pancreatic necrosis and edema of pancreatic tail and surrounding adipose tissue are visible (arrows).


A-d CT scans after VARD. After transgastric necrosectomy, VARD, and percutaneous drainage, all the retroperitoneal necrotic collections dramatically reduced (arrows).


The axial T1.


T2 W/FLAIR. Image shows cerebellar vermis lesion that was hypointense on T1WI and heterogeneous on T2WI, vith perilesional edema, and triventricular hydrocephalus.


H&E x100 specimen of pancreatic tail displaying multifocal high-grade intraductal papillary mucinous neoplasia. H&E, hematoxylin and eosin.


Magnetic resonance cholangiopancreatography demonstrating a new development of enhancement of a branch duct cystic lesion most distally.


H&E x100 specimen of pancreatic tail displaying multifocal high-grade dysplasia pancreatic intraepithelial neoplasia-3.


Composite oral cavity defect. Through-and-through defect following composite mandibular resection and resection of the entire chin pad.


Simultaneous harvest of anterior tibial perforator free flap and fibular osteocutaneous free flap. Anterior tibial perforator supplying the anterior border of skin paddle.


Fibular free flap plated into a reconstruction plate, shown with attached anterior tibial perforator flap (ie, flow-through free flap). Anterior tibial perforator sewn to the distal end of the peroneal artery, microvascular anastomosis for flow-through free flap performed in the leg (short arrow). Vasculature of fibula anastomosed to the right facial artery, the external jugular vein, and a large common facial vein (long arrow).


Inset of fibular flow-through free flap. Reconstruction of composite defect. Blue stitch located at the site of anterior tibial perforator.


Lactophenol Cotton Blue mount of slide culture showing funnel shaped sporangia and sporangiospores of Apophysomyces elegans.


Extensive anterior abdominal wall necrosis, blackened edge of the lesion.


Intraoral photograph after the bite opening with orthodontic appliance.


Intra-operative photograph of surgical technique;. After flap reflection.


After bone splitting, and ,bone fill.


After suturing.


Posttreatment photograph of the patient;. After 1 week.


After 2 weeks frontal, and ,maxillary occlusal view.


With prosthesis.


Representation of the patient phenotype. (a,b) The patient showed distal tremors, hypertonia, trunk hyperextension, spasticity, microcephaly, craniofacial disproportion, and a decreased vertical skull size.


Representation of the patient phenotype. (c) Multiple dimples and arthrogryposis.


Representation of the patient phenotype. (d) Feet contractures and prominent calcaneus.


Representation of the patient phenotype. (e) Clenched fists, hand contractures, and camptodactyly.


Representation of the patient phenotype. (f) Strabismus.


Representation of the patient phenotype. (g) Excess skin over the entire scalp and forehead and occipital and nuchal skin folds, generating the appearance of a short neck.


Representation of the patient phenotype. (h) Sloping of the forehead and prominence of supraorbital ridges, which creates an appearance of proptosis and oversized facial features, epicanthal folds, and retrognathia. Bilateral depressions were present on the forehead.


CECT showing the heterogeneously enhancing mass arising from the pancreas.


Operative and postoperative image.


Specimen with tumour and spleen.


Hematoxylin and eosin staining.


S100 staining.


PET scan.


Gangrenous digits of the patient.


Ulcerated jugulodigastric node.


Histological specimen of jugulodigastric lymph node. Notes: (A) Biopsy from the ulcerated jugulodigastric node showing spindle cell carcinoma.


Histological specimen of jugulodigastric lymph node. (B) Cytology smear from the ulcerated jugulodigastric node showing spindle cell carcinoma.


Lymphangitis carcinomatosis involving the right lobe and mediastinal adenopathy.


Computed tomography scan of abdomen.


Pathology demonstrating small bowel inflammation.


Pathology demonstrating ulceration of the small bowel.


Imprint from bone marrow biopsy. Giemsa stain. x1,000.


Bone marrow trephine biopsy. A; Intertrabecular space completely filled by angiosarcoma. The lesion shows multiple anastomosing vascular channels (HE. X100).


Bone marrow trephine biopsy. B; Vascular spaces lined by endothelial cells with mild to moderate atypia, surrounded by spindled neoplastic cells (HE. X400).


Immunohistochemical staining of the bone marrow biopsy. A CD31 positivity in neoplastic cells (x400). B; Factor VIII positivity in neoplastic cells (x400).


Confirmation of novel IL-10RA variants. (A) c.395T>G variant (red arrow) confirmed by Sanger sequencing.


Confirmation of novel IL-10RA variants. (B) Validation of the ex.1del (p. ?) variant by quantitative PCR. Genomic DNA was extracted from peripheral blood from the patient, her parents and healthy controls. Reactions were set up using one set of primers upstream and downstream of exon 1 in triplicate. The beta-actin gene served as a reference gene. The 2-DeltaDeltaCT method was used to calculate the copy number. Samples with normalized ratios (NRs) <0.1 denote individuals with homozygous deletion, samples with NRs of about 0.5 denote individuals with heterozygous deletion, sample with NRs of ~1 denote healthy individuals (two copies), and samples with NRs of ~1.5 or more denote individuals with copy number gain.


Brain stem degeneration presents in brain MRI. Sagittal.


Brain stem degeneration presents in brain MRI. Transversal. T2-weighted brain MRI indicates gliotic neurodegeneration in the medulla oblongata with predominant loss of pyramidal tracts.


Brain stem degeneration presents in brain MRI. Magnification of inlay (c) uncovers pathologic brain stem formation reminiscent of 'kissing swans.


Brain stem degeneration presents in brain MRI. D; Transversal T1-weighted sectioning of the brain stem (arrow) after Gadolinium administration. No contrast enhancement is detectable.


Brain stem degeneration presents in brain MRI. E; Sagittal T2-weighted cervical spine MRI shows atrophy of the upper cervical spinal cord in addition to medulla oblongata atrophy.


Brain stem degeneration presents in brain MRI. F; Transversal T2-weighted brain MRI indicates putative periventricular rim-sign and global brain atrophy.


Brain stem degeneration presents in brain MRI. G; Brain MRI-angiography reveals normal intracranial vascular status without indication of stenosis.


CT of abdomen and pelvis. Multiple bilateral renal stones measuring between 1 and 4 mm. Bilateral pelvocaliectasis. No discrete renal lesions although renal fungal ball cannot be excluded.


Renal ultrasonography. Seven millimeter, left sided interpolar nonshadowing hyperechoic foci in the renal collecting system.


Liquid-based cytology smear shows an uncoiled, eosinophilic, shrunken, thin organism in a background of superficial and intermediate cells (pap, x40).


Peripheral blood smear showing the presence of a microfilaria which appeared as coiled basophilic thick organism with nuclei (pap, x100).


Liquid-based cytology smear shows an eosinophilic, shrunken, thin elongated organism in a background of superficial and intermediate cells (pap, x40).


Liquid-based cytology on higher magnification revealing nuclei not extending up to the tail (pap, x100).


Multiparametric flow cytometry shows two distinct clones (CD19pos and CD19neg) of cells both of which are positive for CD45, CD22, CD10, CD25, CD103, CD11c, CD123 and surface Igkappa in similar intensities. The plasma cells do not show clonal restriction.


Clinical course of a patient.


White membrane adherent to the pharynx noted on oropharyngeal examination on presentation in a 14-month-old incompletely vaccinated infant with respiratory distress.


Chest computed tomography (CT) showed multiple space-occupying lesions. The arrows indicate the lesions.


Clinical photograph showing close-up view of skin abscess on the volar aspect of the patient's right wrist.


Photograph of skin abscess surrounded by skin erythema taken 2 days later.


Photograph of completely healed wrist wound taken 2 months later.


The CT scan of this patient showed lung metastases from synovial sarcoma at the baseline in February 2015 (A).


At the first radiological evaluation in April 2015 there was a partial response (B).


The patient was on drug holiday from June 2016 to April 2018 when the same lesion started to grow again (C).


It then showed a good response to Trabectedin re-challenge in July 2018 (D).


Lung metastases from uterine leiomyosarcoma right before starting Trabectedin in November 2015.


Showing an almost complete response after treatment in February 2016 Systemic therapy was then suspended for a drug holiday.


During this period the lesion began to grow again in December 2017 (C).


However, in March 2018 after Trabectedin re-challenge a new partial response was observed (D).


This patient showed hypervascular liver metastases from retroperitoneal leiomyosarcoma at the baseline CT scan in April 2015 (A).


The lesions were reduced in both size and vascularisation after treatment with Trabectedin, which was stopped in December 2016 (B) for a drug holiday.


This patient experienced in June 2016 disease progression with multiple peritoneal lesions at MRI (A) after being treated with Trabectedin and surgery.


However, Trabectedin showed to be effective again, achieving a partial response in February 2018 (B).


Clinical findings and MRI images. (A) A reddish mass of 4-mm diameter is seen under the nail plate (area surrounded by the triangle mark). Distal nail splitting is observed in the left thumb.


Clinical findings and MRI images. (B) T1-weighed magnetic resonance image shows tumor with normal intensity.


Clinical findings and MRI images. (C) T2-weighed magnetic resonance image shows high-intensity lesion. Flow void is indicated by an arrow. MRI: magnetic resonance imaging.


Surgical findings. (A) A reddish mass is seen under the nail plate. The excision line after the nail claw is indicated in blue.


Surgical findings. (B) After excision, skin grafting was performed from the thenar eminence.


Histopathological findings. (A) A loupe image. An incompletely encapsulated tumor.


Histopathological findings. (B) A middle-power view. The tumor is composed of fine collagen fibers pointed in every direction.


Histopathological findings. (C) A high-power view. Nuclei of the proliferating cells are spindle- or comma-shaped. Among the tumor cells, capillaries and a small number of mast cells are dispersed (indicated by arrows).


Histopathological findings. (D) Appearance of new thumb nail six months postoperatively. This observation is natural.


A; Oral ulcer contained and surrounded by polymorphonuclear cells and confined cell debris; outside this zone and extending diffusely throughout the lamina propria, a large number of infiltrating lymphocytes and macrophage-like cells were seen (x40).


B; Inflammatory cell infiltrate (CD8+ stained; antibody CONFIRM anti-CD8, SP57) associated with oral mucosa ulceration (x10).


A; G banded karyogram was completed in 1997. The unidentified SMC is indicated by the arrow. Karyotype: 47,XY,+r /46,XY.


Magnetic resonance imaging scans from first clinic encounter. Sagittal T1 postcontrast image, showing prepontine cystic lesion (red arrow).


Magnetic resonance imaging scans from first clinic encounter. Axial T1 postcontrast image.


Magnetic resonance imaging scans from first clinic encounter. Axial T2 image.


Magnetic resonance imaging scans from follow-up after 3 months. Sagittal T1 postcontrast image showing decrease in size of cyst (red arrow).


Magnetic resonance imaging scans from follow-up after 3 months. Axial T1 postcontrast image.


Magnetic resonance imaging scans from follow-up after 3 months. Axial T2 image.


Magnetic resonance imaging scans from most recent follow-up. Sagittal T1 postcontrast image, note the normal contour of brainstem.


Magnetic resonance imaging scans from most recent follow-up. Axial T1 postcontrast image.


Magnetic resonance imaging scans from most recent follow-up. Axial T2 image.


Testicle without fixation, extensively infiltrated by cream-colored neoplasia (*) and with areas of necrosis.


Immunohistochemical analysis showing a positive reaction for myeloperoxidase, labeling the neoplastic cells (brown) with preservation of the seminiferous duct (negative) on the right side of the image (magnification 400X).


Electron microscopic findings at the first renal biopsy. Several microspheres are shown in the GBM of a capillary loop (arrowheads).


Visual field tests using a Goldmann perimeter. . Notes: (A) Central and paracentral scotomas were observed in the left eye at the initial ocular examination.


Visual field tests using a Goldmann perimeter. (B) Regression of visual field defect was observed in the left eye at 2-month follow-up after pulse steroid therapy.


(a) Computed tomography revealing diffuse subarachnoid hemorrhage.


(b) 3D-reconstruction of digital subtraction revealing a broad base small aneurysm of the basilar tip.


(c) Digital subtraction angiography revealing quite high basilar tip in relation to the dorsum sella.


(d) Postoperative digital subtraction angiography revealing the total obliteration of the aneurysm.


Preoperative computed tomography-angiography.


Digital subtraction angiography. Revealing right posterior communicating artery-posterior cerebral artery and left P1 segment aneurysms.


Postoperative intravenous-digital subtraction angiography (c, d) revealing the total obliteration of the aneurysm with presentation of the P1 perforating branch.


Cycle threshold value of SARS-CoV-2. Blue: Nasopharyngeal swab. Red: Sputum.


mNGS detection and anti HHV-1 therapy. Acyclovir: 0.5 g intravenous every 8 h from Day 19 to Day 35.


A and b, H&E stained pictures showing parakeratinized stratified squamous epithelium overlying the connective tissue components and clusters of eosinophilic toto bodies in the upper spinous cell layer (10x).


H&E picture showing the presence of nonkeratinized stratified squamous epithelium showing areas of eosinophilic Toto bodies (10x).


H&E-stained picture showing hyperplastic epithelium and superficially confined Toto bodies with few focal areas showing a break in the continuity of the basement membrane (black arrow). Subepithelial connective tissue is composed of severe inflammatory cell response mainly composed of lymphocytes and plasma cells (4x).


H&E-stained picture showing that the deeper connective tissue is composed of moderately differentiated epithelial cell population arranged in the form of sheets and cords and presenting dysplastic epithelial cells with nuclear and cellular pleomorphism (black arrow) and nuclear hyperchromatism (arrowhead) (20x).


(a) MRI brain with contrast demonstrated 4.7 cm multiloculated rim enhancing cystic lesion with additional smaller projections invading the right frontal lobe with associated vasogenic edema and midline shift.


(b) MRI brain with contrast demonstrating resection of right frontal mass with expected postoperative changes.


(c) MRI brain with contrast demonstrating enhancing foci within left frontal lobe adjacent to prior surgical cavity.


(d) MRI brain with contrast demonstrating resection of left frontal foci with expected postoperative changes.


MRI with contrast.


MRI T2WI.


Medical image.


ADC. MRI Head demonstrating right frontoparietal subdural collection with associated vasogenic edema and restriction on DWI and ADC maps.


(a) MRI T1W with contrast four-weeks post-surgical evacuation of subdural collection and initiation of platinum-based chemotherapy demonstrating marked improvement.


(b) MRI T1W with contrast eight-weeks following initiation platinum-based chemotherapy demonstrating marked progression of invasive tumor in the right parietal and posterior frontal lobes, extensive vasogenic edema extending to the atrium of the right lateral ventricle and midline shift.


Exophytic growth in relation to 42, 43, 44, and 45.


Multilocular radiolucency with many radiopaque spots of driven snow appearance.


Computed tomography reconstructed image of the lesion.


Epithelial cells with prominent intercellular bridge and amyloid-like material.


Leisegang ring calcifications and amyloid-like material in connective tissue stroma.


Fused coronal PET-CT image of our patient before the axillary lymph node biopsy shows a lobulated FDG-avid mass (star) in the right axilla, which represents the patient's known axillary invasive ductal carcinoma. An adjacent small FDG-avid round structure (arrow) was suspicious for metastatic axillary lymphadenopathy.


A; Abdominal CT shows marked dilation of the transverse and descending colon with localized high-density areas.


B; Barium enema examination shows irregular mucosal contours and barium flecks in the transverse and descending colon.


Response to treatment in Case 1. Calcium levels in relationship to denosumab administration, and ,PRRT cycles in case 1.


Response to treatment in Case 1. Anterior view of 177Lu-LUTATHERA scintigraphy after I, II, and ,IV cycles of PRRT.


Response to treatment in Case 1. Posterior view of 177Lu-LUTATHERA scintigraphy after I, II, and IV cycles of PRRT.


Histopathology findings.


Maximum intensity projection image 18F-FDG PET-CT shows multiple distant metastasis in the lung, liver and bones. . Abbreviations: CT, computed tomography; FDG, fluorodeoxyglucose; PET, positron emission tomography; dm, mean decimeter.


Cutaneous nodule.


Diffuse esophageal ulceration.


Fine needle aspiration cytology from cutaneous lesion.


Specimen of spleen with a cyst measuring 8 cm x 8 cm, with cyst wall showing trabeculations.


Intra-operative visualisation of the diverticulum and gangrenous perforation of the diverticulum with impending obstructive symptoms. Blue arrow indicates the visualization of gastric mucosa in MD on a Meckel's scan ; green arrow indicates the CT observation of MD; yellow arrow indicates the post-operative specimen of MD with the distal gangrenous perforation.


Initial CT head showed subarachnoid haemorrhage (SAH) present in the frontal horn of the left lateral ventricle, third ventricle and fourth ventricle, and the foramen magnum; yellow arrows indicate blood component in the scans.


A diagram of timeline for this case.


A) Demonstrates conglomerate of para-aortic retroperitoneal lymphadenopathy at diagnosis of primitive neuroectodermal tumor. Patient went on to receive cheomtherapy with VAC/IE.


B) Demonstrates parital response to chemotherapy prior to potentially curative surgical resection.


Primitive neuroectodermal tumor (Case 1) consisting of a large confluent aggregate of immature neuroepithelium that forms tubules lined by stratified cells (inset picture) was identified in the orchiectomy sample.


Clinical course of the patient (schematic). BDG, (1,3)-b-D-glucan; PCT, procalcitonin; CRP, c-reactive protein; CT, computed tomography; MRI, magnetic resonance imaging; MRA, magnetic resonance angiography; VRC, voriconazole; IPI, Imipenem; VAN, Vancomycin; TEC, teicoplanin; AmBL, liposome-associated amphotericin B; mNGS, metagenomics next-generation sequencing; PB, peripheral blood; CSF, cerebral spinal fluid; BAL, bronchoalveolar lavage fluid.


Daily course of the patient's treatment. Horizontal thick blue lines show the medications administered; VRC, voriconazole; AmBL, Liposome-associated amphotericin B; TZP, piperacillin-tazobactanm; IPI, Imipenem; PCT, procalcitonin; CRP, C-reactive protein.


Frontal view of patient showing dark brown papules having linear distribution, limited on the right side of the face.


Intraoral photograph showing desquamative gingivitis and enamel hypoplasia in relation to 13 and 42.


Radiograph of the lumbar spine showing mild scoliosis with congenital Schmorl's node at D-12,. 3,. . 4,. . 5 (red arrow), and spina bifida (yellow arrow).


Retinography of the LE showing multiple, round and yellowish lesions in the macula and nasal to the optic nerve (left).


OCT with detachment of the neuroepithelium and a slight RPE detachment.


FA revealing hyperfluorescent lesions. At presentation.


Retinography of the LE performed 1 year later, revealing a chorioretinal scar.


Patient with Crouzon Syndrome, with cranio-cervico-facial involvement after a surgical procedure of cervicofacial advancement whit septic shock and acute and chronic osteomyelitis. A) Bilateral areas of ecchymosis were observed in the cervico-maxillary region.


Patient with Crouzon Syndrome, with cranio-cervico-facial involvement after a surgical procedure of cervicofacial advancement whit septic shock and acute and chronic osteomyelitis. B) Necrotic areas in the cervical, frontal, temporal and occipital regions.


Patient with Crouzon Syndrome, with cranio-cervico-facial involvement after a surgical procedure of cervicofacial advancement whit septic shock and acute and chronic osteomyelitis. C) Infected area with Pseudomonas aeruginosa.


Patient with Crouzon Syndrome, with cranio-cervico-facial involvement after a surgical procedure of cervicofacial advancement whit septic shock and acute and chronic osteomyelitis. D) Once the infection was controlled after multiple surgical lavages and debridation, broad spectrum antibiotics, VAC and hyperbaric oxygen the skin grafts were placed.


Patient with Crouzon Syndrome, with cranio-cervico-facial involvement after a surgical procedure of cervicofacial advancement whit septic shock and acute and chronic osteomyelitis. E) The patient was discharged from the hospital.


Patient with Crouzon Syndrome, with cranio-cervico-facial involvement after a surgical procedure of cervicofacial advancement whit septic shock and acute and chronic osteomyelitis. F) Bone scintigraphy. - the bone scan images showed abnormal increased uptake of 111In in the right temporal region.


HTT (superior) juxtaposed with uninvolved thyroid parenchyma (inferior) with intervening fibrous capsule (H&E, 200X).


(A) Clinical observations according to the canine inflammatory bowel disease activity index score. A score of 3 or less was considered normal. * indicates the date of each fecal microbiota transplantation (FMT) procedure conducted. Of note, the patient with inflammatory bowel disease (IBD) achieved a normal score from day 42 of FMT throughout the remainder of the observation period.


(B) Clinical observations according to the WalthamTM Feces Scoring System. A score of 3.5 or less was considered normal. *indicates the date of each FMT procedure conducted. Of note, the patient with IBD achieved a normal score from day 42 throughout the remainder of the observation period.


Patch of woolly hair over the vertex.


Linear epidermal nevus over chin.


Light microscopy showing twisting and breakage of hair.


Trichoscopy showing irregularity of hair shaft.


Black arrow showing tumor cells with cytoplasmic PSA positivity (x 100).


T2 sagittal MRI of the thoracic spine showing both fractures.


T2 sagittal and coronal magnetic resonance imaging just above the T3-T4 levels on top of conus.


Microphotograph showing closely placed small capillary sized vascular channels along with a few dilated ones x200. Note the prominent endothelial cells and fibrin thrombus (*).


CD31 immunohistochemistry highlighting the endothelial cell line capillary channels (x200).


Preoperative contrast-enhanced abdominal computed tomography (CT) scan, axial arterial phase. The images reveal a low-density mass (red arrow head) measuring about 8.2 x 7.6 cm in diameter and prominently involving the uncinate process of the pancreas. The pancreatic head and neck are displaced and splayed around the anterior aspect of the tumor, certainly abutting the superior mesenteric artery (SMA; red arrow).


Histopathological photomicrographs of a solid pseudopapillary tumor (SPT). The image shows that the small round cells arranged and formed into nests, pseudopapillae, and microcysts. Note the tumor cells are traversed by a delicate vascular network. (Hematoxylin and eosin, original magnification, x20).


(A, B) Contrast-enhanced abdominal CT scan on postoperative day 1. A = axial. B = coronal. The images reveal an intraluminal thrombus (red arrow) in the proximal SMA ~1.5 cm from its aortic origin, causing near complete occlusion of the SMA.


Clinical course. beta-hCG = human beta subunit of chorionic gonadotropin; Cre = creatinine; im = intramuscular injection; MTX = methotrexate; PSL = prednisolone; RB = renal biopsy; UP = urinary protein.


Light microscopy of initial renal biopsy specimens shows thickening of the glomerular capillary walls, thrombus-like structures within the glomerular capillary lumina, and a double-contour appearance along the glomerular capillary walls. Masson's trichrome stain x 400.


Light microscopy of initial renal biopsy specimens shows thickening of the glomerular capillary walls, thrombus-like structures within the glomerular capillary lumina, and a double-contour appearance along the glomerular capillary walls. Periodic acid-methenamine-silver stain x 400).


C: Immunofluorescence microscopy shows positive staining for IgM along the glomerular capillary walls.


D: Electron microscopy shows the expansion of the glomerular subendothelial space with electron-dense aggregates.


Light microscopy of follow-up renal biopsy specimens shows normal glomerular structures. Masson's trichrome stain x 400.


Light microscopy of follow-up renal biopsy specimens shows normal glomerular structures. Periodic acid-methenamine-silver stain x 400).


GCTTS presenting in a young child. (A) Presence of a soft tissue mass along the third digit of left hand.


GCTTS presenting in a young child. (B) Hematoxylin and Eosin (H&E) staining of resected finger mass consistent with a diagnosis of GCTTS. Arrowheads indicate multinucleated giant cells.


CT scan of right lower extremity. . Extensive air is shown tracking superiorly within the anterior and posterior compartments of the thigh (notated by white arrows).


Intra-operative photo of right lower extremity. . Taken during initial AKA revision and soft tissue debridement for extensive necrotizing infection.


Right lower extremity wound. . Integra graft over viable muscle of anterior, lateral, and posterior compartments of right thigh. Photo taken post-operative day #19 after AKA revision procedure.


(a) Positron emission tomography-computed tomography scan showing fluorodeoxyglucose uptake in distal ileum, (b) ileal biopsy showing confluent granulomas with epithelioid cells and multinucleated Langhans giant cells (H and E, x20), (c) Ziehl-Neelsen stain of the ileal tissue showing acid-fast bacilli.


(a) Orthopantomograph showing multilocular radiolucency in the mandibular body-ramus area on the left side.


(b) Cone beam computed tomography image showing buccal expansion due to the lesion.


(a) Photomicrograph demonstrating follicles of ameloblastoma in mature fibrous stroma (H&E, x10).


(b) Foreign body and associated granulomas (H&E, x10).


(c) Multinucleated giant cells phagocytosing hyaline ring-like foreign particles (H&E, x40).


(d) The foreign body demonstrating periodic acid-Schiff positivity (periodic acid-Schiff, x10).


(a) Foreign body showing peripheral smaller rectangular cells (demonstrated by arrowhead) and arrow pointing larger more angular cells in the center enclosing amorphous eosinophilic material (H&E, x40).


(b) Processed pulse showing structure similar to the foreign body (H&E, x40).


Microscopic: sections show dense spindle cell proliferation with storiform growth pattern associated with patchy infiltration of lymphoplasma cells.


Positive reaction of tumor cells with SMA.


A single, dome-shaped, swelling is seen at the left index figure without significant changes of the overlying skin. Tumor nodule measures 2.0 x 2.3 cm in size.


Electron microscopy of liver biopsy. (A) Hepatocytes are irregular in shape and size, and the nucleus is eccentric (3,000 x, scale bar: 10 mum).


Electron microscopy of liver biopsy. (B) Part of the capillary bile duct is dilated; a large number of microvillous and lysosomes are visible (9,000 x, scale bar: 5 mum).


Electron microscopy of liver biopsy. (C) Hyperplasia of collagen fibers can be seen in liver cells, with cross-sections (*). The picture also presents with an increased number of mitochondria with abnormal morphology ( ) and an increased density of rough endoplasmic reticulum ( ) (9,000 x, scale bar: 5 mum).


Optic pathway gliomas and computed tomography of Case 1.


Intraoperative photograph with excised lesion and histopathological photographs of Case 1.


Optic pathway gliomas and computed tomography of Case 2.


Intraoperative photograph with excised lesion and histopathological photographs of Case 2.


Nests of monomorphic cuboidal poroid cells with prominent nucleoli (hematoxylin & eosin stain).


Eccrine porocarcinoma composed of basaloid cells with focal infiltration into the dermis (hematoxylin & eosin stain).


Low-power photomicrograph depicting granular layer with associated keratinization consistent with epidermoid-infundibular cyst. HE staining.


Medium-power view showing atypical squamous epithelium with focal infiltration and associated stromal response. HE staining.


Medium-power view demonstrating keratinizing tumor cells with mitotic figure. HE staining.


Array-CGH profile of the patient showing a 2.8 Mb loss at 15q26.3 and 496 kb gain at 15q26.3 ie arr[GRCh37] 15q26.3(99550797_102429040)x1,15q26.3(99049746_99546177)x3.


Specimen radiographic appearance of the jaw eliciting the multilocular radiolucency with root resorption postero-anteriorly.


Radiographic appearance of the jaw eliciting the multilocular radiolucency with root resorption.


The microscopic appearance exhibiting fibrous connective tissue exhibiting numerous odontogenic epithelial islands with peripheral tall columnar cells showing reversal of polarity. The center of the island shows stellate reticulum like cells which is replaced by granular cells (inset) (under x10 magnification).


The microscopic appearance shows central stellate cells replaced by large eosinophilic rounded or polyhedral granular cells (under x10 magnification).


The microscopic appearance of granular cell (under x40 magnification).


Coronal.


Sagittal. CT images showing a loculated cystic lesion in the tail of the pancreas closely involving the spleen.


Three biopsy pathological diagnosis results of the patient.


Chest CT scan evolution of the tumors.


Pedigree analysis: Pedigree analysis of the proband up to the previous three generations. White symbol (square or circle) - a healthy person, white symbol (square or circle stroked through diagonally) - death of that individual, triangle - miscarriage, white symbol (blue colored and stroked diagonally) - proband.


Preoperative clinical presentation of the lesion.


Proliferating keratinizing stratified squamous epithelium into underlying connective tissue (4x).


Islands of odontogenic epithelium within a cellular fibrous stroma (10x).


Islands of odontogenic epithelium within a cellular fibrous stroma (40x).


Postoperative view.


Hip, thigh, and lower calf MRIs of the proband (II-3) with PRX mutation. A: Coronal scan of lower limbs. T1-weighted images demonstrated no definite fatty or atrophic changes in hip and thigh muscles.


Hip, thigh, and lower calf MRIs of the proband (II-3) with PRX mutation. B-E: Axial scans of lower limbs. B and C: At the thigh levels, MR images were normal.


Hip, thigh, and lower calf MRIs of the proband (II-3) with PRX mutation. B-E: Axial scans of lower limbs. D and E: On the lower calf levels, we found mild fatty changes in distal peronei muscles (arrows), but, the tibialis anterior and soleus muscles were not involved.


Preoperative magnetic resonance images. Axial unenhanced T2 weighted magnetic resonance imaging showing right-sided lesion (white arrow) and hyperdense areas which extends to the left cerebellum (hemorrhage) and there is no edema round the lesion.


(b) Axial postcontrast T1 image, showing bilateral vermian lesions in which the right-sided mass is enhancing gadolinium peripherally.


(c) Postcontrast sagittal image, demonstrating partly attachment of the mass to the tentorium.


(d) Postcontrast coronal image demonstrates bilateral lesions close to the tentorium in mixt intensity.


(a-d) Intraoperative images. (a) Initial surgical view of the tumor, originating from the tentorium (white arrow) after retraction of cerebellum inferiorly.


(a-d) Intraoperative images. (b) Bipolar coagulation of the tumor feeders and detachment of the tumor from the tentorium.


(a-d) Intraoperative images. (c) Surgical view of the tumor (white arrow) after total detachment.


(a-d) Intraoperative images. (d) Removal of the tumor in a single piece (white arrow) fashion.


(a-c) Postoperative magnetic resonance images demonstrating no residual tumor. (a) Axial enhanced T1 imaging.


(a-c) Postoperative magnetic resonance images demonstrating no residual tumor. (b) Sagittal enhanced T1 imaging.


(a-c) Postoperative magnetic resonance images demonstrating no residual tumor. (c) Coronal T2 imaging.


CECT of brain showing right parietal parasagittal metastatic tumor.


MRI of cervico-dorsal spine demonstrating C6-D2 spinal tumor with dumbbell like extension into upper thorax.


MRI axial images demonstrating spinal tumor at D-1 extending outside.


Histopathology showing densely cellular tumor arranged in sheets, and ,lobules with minimal intervening stroma.


Immunohistochemistry showing membranous positivity for CD99.


Post-operative CECT brain at nine months after surgery showing no evidence of tumor.


Axial view magnetic resonance images show a mass at the T11 and T12 level, pushing the conus medullaris superiorly and to the right.


Intraoperative picture, post-laminectomy at T11 and T12 level.


Intraoperative picture, the tumor was excised along with the involved nerve root.


Sagittal view magnetic resonance images showing an intramedullary mass adjacent to the conus medullaris at T11 and T12 level.


Axial view magnetic resonance images show a mass at the T11 and T12 level, abutting on the conus medullaris.


Intraoperative picture post-laminectomy of T11 and T12 reveals the mass.


Intraoperative picture, the mass was completely removed without having to sacrifice the nerve root.


Sagittal view magnetic resonance image reveals an intradural mass at T11 level.


Axial view magnetic resonance image shows a well-defined intradural extramedullary mass at T11 level, compressing the conus medullaris.


Intraoperative picture post-laminectomy T10 and T11 reveals the mass.


Intraoperative picture, the mass was completely without sacrificing the affected nerve root.


Skin manifestation after bagatelle injury on day 11 after admission.


Intraoperative appearance after initial radical debridement on day 11 after admission.


Areactive necrosis of subcutaneous fat and fascia without detection of bacteria (H&E, 200x).


Diagram of the course of disease.


Photograph of patient on postembolization day 4, demonstrating hyperpigmented plaque on her left nasal ala and cheek with surrounding erythema.


Case 1. 58-year-old male with difficulty in swallowing was diagnosed with squamous cell carcinoma of right tonsil. A) Maximum Intensity Projection (MIP) image shows tonsillar SCC infiltration in both lobes of the thyroid gland (arrows).


Case 1. 58-year-old male with difficulty in swallowing was diagnosed with squamous cell carcinoma of right tonsil. B) Axial CT image for attenuation correction and anatomic localization.


Case 1. 58-year-old male with difficulty in swallowing was diagnosed with squamous cell carcinoma of right tonsil. C) Axial PET image shows diffuse tracer uptake in both lobes of the thyroid gland (arrows).


Case 1. 58-year-old male with difficulty in swallowing was diagnosed with squamous cell carcinoma of right tonsil. D) Axial PET/CT fusion image reveals SUVmax of the right and left thyroid lobes was 7.5 and 5.9, respectively (arrows).


Case 2. 66-year-old male complaining of a mass in the neck was diagnosed with supraglottic squamous cell carcinoma. A) Maximum Intensity Projection (MIP) image shows supraglottic SCC metastasis in both lobes of the thyroid gland (arrows).


Case 2. 66-year-old male complaining of a mass in the neck was diagnosed with supraglottic squamous cell carcinoma. B) CT image for attenuation correction and anatomic localization.


Case 2. 66-year-old male complaining of a mass in the neck was diagnosed with supraglottic squamous cell carcinoma. C) Axial PET image shows intense metabolic activity in both lobes (arrows).


Case 2. 66-year-old male complaining of a mass in the neck was diagnosed with supraglottic squamous cell carcinoma. D) Axial PET/CT fusion image reveals SUVmax of the right thyroid lobe was 20.3 and SUVmax of the left lobe was 7 (arrows).


Left: Preoperative abdominal CT. Solid hepatic lesion at segments VI and VII (arrows) and calcified lesion at the tail of the pancreas (circle). Right: Postoperative abdominal CT. Subcapsular hepatic fluid collection without recurrence of the HCC (circle). . Abbreviations: CT, computed tomography; HCC, hepatocellular carcinoma.


Left: Intraoperative photo. Microwave tissue coagulator marking the margins for hepatic segmentectomy. Right: Gross specimen photo. Hepatic segments VI and VII containing the HCC. . Abbreviation: HCC, hepatocellular carcinoma.


The intraoperative photographs and schematic renderings show details of the operation. . Notes:. A sizable segment of IVC around the lesion was freed, and ,detached, where two Satinsky's clamps were placed at the proximal part to occlude the IVC without affecting the left renal vein.


The intraoperative photographs and schematic renderings show details of the operation. The granuloma (blue arrow) was exposed and detached from posterior tissue after the proximal IVC segment was ligated, cut off, and stretched caudally.


The intraoperative photographs and schematic renderings show details of the operation. (C and D) The sketch illustrations explain the key steps straightforward. (C) The granuloma was attached posterior to the IVC (arrow).


The intraoperative photographs and schematic renderings show details of the operation. (C and D) The sketch illustrations explain the key steps straightforward. (D) The IVC was ligated and sutured after the granuloma was removed (arrow). . Abbreviation: IVC, inferior vena cava.


The photographs and microscopic pathological presentation of the surgical specimen. . Notes:. Grossly, the granuloma sized 2.6x3 cm is covered by a fragment of inferior vena cava.


The photographs and microscopic pathological presentation of the surgical specimen. The arrowheads indicate the surgical suture.


The photographs and microscopic pathological presentation of the surgical specimen. Numerous epithelioid histiocytes, multinucleated giant cells, and the amorphous necrotic fat are present.


Anterioposterior digital subtraction angiogram of the celiac artery: (a) early arterial phase shows arterial feeders which supply the hypervascular tumor.


(b) Mid-arterial phase, revealing marked coarse neovascularity and significant arterio-venous shunting, as demonstrated by early visualization of the left and right portal veins (arrows), typical for hepatocellular carcinoma.


(c) Late arterial phase, tumor blush and delayed contrast washout with persistent opacification of the portal system (arrows).


Computed tomography angiogram, axial and coronal images (a and b) indicating the site of the hepatocellular carcinoma in segments 7/8 (arrows).


Corresponding axial and coronal SPECT/ CT images (c and d). Note only minimal accumulation of MAA in segment 7/8 tumor, while more intense tracer uptake is noted in the surrounding normal hepatic parenchyma.


Pre-operative.


Excised tissue.


Post-operative.


Pre-operative (lateral view).


After excision.


Periodontal dressing.


Histopathologic slide.


Clinical presentation of NEC and SCC. Esophagogastroduodenoscopy and CT findings in NEC (A,B). (A) A large ulcerated mass was found in the esophagogastric junction.


Clinical presentation of NEC and SCC. Esophagogastroduodenoscopy and CT findings in NEC (A,B). (B) CT imaging reveals para-aortic lymph node swelling (yellow arrow).


Clinical presentation of NEC and SCC. Esophagogastroduodenoscopy and CT findings in SCC (C,D). (C) A tiny, red-colored mucosal area in the center of the cicatrized lesion (white arrow).


Clinical presentation of NEC and SCC. Esophagogastroduodenoscopy and CT findings in SCC (C,D). (D) CT imaging shows no distant metastasis after the chemotherapy for NEC.


Clinical presentation of NEC and SCC. (E) Macroscopic findings for the resected specimen. No other regional/distant metastasis can be seen in the resected specimen.


Clinical presentation of NEC and SCC. (F) An ulcerated mass at the esophagogastric junction can be observed in the resected specimen (white arrow). NEC, neuroendocrine carcinoma; SCC, squamous cell carcinoma; CT, computed tomography.


Histological evaluation of NEC and SCC. Hematoxylin and eosin, and immunohistochemical staining of the biopsy (NEC;. E staining.


Histological evaluation of NEC and SCC. Hematoxylin and eosin, and immunohistochemical staining of the biopsy (NEC;. Synaptophysin.


Histological evaluation of NEC and SCC. Hematoxylin and eosin, and immunohistochemical staining of the biopsy (NEC;. CD56.


Histological evaluation of NEC and SCC. Hematoxylin and eosin, and immunohistochemical staining of the biopsy (NEC;. MIB-1.


Histological evaluation of NEC and SCC. Hematoxylin and eosin, and immunohistochemical staining of the biopsy (NEC;. P53. NEC, neuroendocrine carcinoma; SCC, squamous cell carcinoma; H-E, hematoxylin and eosin.


Histological evaluation of NEC and SCC. And surgically resected specimen (SCC.


Histological evaluation of NEC and SCC. And surgically resected specimen (SCC;. Synaptophysin.


Histological evaluation of NEC and SCC. And surgically resected specimen (SCC;. CD56. NEC, neuroendocrine carcinoma; SCC, squamous cell carcinoma; H-E, hematoxylin and eosin.


Histological evaluation of NEC and SCC. And surgically resected specimen (SCC;. P53.


Histological evaluation of NEC and SCC. CK5/6. Scale bars; 50 mum.


Transverse view on CT of the bilateral iliopsoas abscesses.


CT demonstrated Sagittal View of Abdomen and Pelvis demonstrating gas locules in Right Iliopsoas Region.


>50% occlusive right internal jugular vein thrombus on ultrasonography.


CECT showing eccentric thickening of gall bladder wall.


MRCP showing dilated bile duct with multiple sites of narrowing.


Smear shows cluster of malignant cells displaying round to oval hyperchromatic nuclei, condensed chromatin, prominent nucleoli, and moderate amount of cytoplasm (MGG, x40 magnification).


Side viewing endoscopy showing ampullary growth.


Metal stent in the bile duct.


Gadolinium-enhanced T1 MRI shows left medullary enhancement (arrow.


As extensive nodular circumferential leptomeningeal enhancement (arrows.