Findings correlate with axial T2 FLAIR images also showing lateral brainstem hyperintensity (arrows.


As well as a patchy involvement of the bilateral midbrain (arrows,. And the pituitary infundibulum (arrowhead.


Intraoperative photograph shows the direct swab of a mycotic-appearing mass which resulted in negative smear and culture. Also seen are a number of small colonies (arrowheads), one of which resulted in the positive identification of blastomyces dermatitidis on culture.


Nontender subungual, nodular lesion in the right toe.


After excision of the lesion.


Immunohistochemical (IHC) study; low power view of neoplastic spindle cells which show IHC positive staining with vimentin.


Focal reaction with smooth muscle actin.


Negative reaction with CD34.


Positive staining pattern with CD99 (IHC x40).


MRI or CT scan images of the patient. Indicated partial enhancement of pia mater in brain enhanced MRI.


MRI or CT scan images of the patient. Revealed an area of abnormal attenuation measuring 67 mm x 62 mm in the right lobe of the liver, indicative of a single large multi-loculated abscess in abdominal enhanced CT.


MRI or CT scan images of the patient. Displayed the abscess reduced to 51 mm x 37 mm 3 days after emergency CT-guided percutaneous drainage of the liver abscess in abdominal plain CT.


MRI or CT scan images of the patient. Showed no lesions in liver in the reexamination of abdominal CT after full recovery.


Swelling on left side of face extending from zygomatic arch to lower border of mandible superoinferiorly. Swelling was covering the whole ramus of the mandible anteroposteriorly.


Intraoral examination shows obliteration of buccal sulcus and displacement of first and second deciduous molar and first permanent molar.


Cytological smears show spindle-shaped stroma with giant cells (40x).


Postoperative follow-up after two months.


Extraoral. Intraoral.


Computed tomography of neck; lymphadenomegalies in various dimensions.


Karyorrhectic debris and cellular infiltration of histiocytes and immunoblasts in the absence of polymorphonuclear leukocytes (hematoxylin and eosin stain x200).


Histiocytes and activated B-cells (hematoxylin and eosin stain x200).


(A) SS-OCT imaging confirms the diagnosis as the lesion can clearly be seen coming up from the sclera and compressing the overlying choroid and choriocapillaris. The lesion is inactive as there is no sign of yellow intraretinal exudation, localized subretinal fluid or focal retinal hemorrhages and the posterior border (arrows) of the lesion is well defined.


(B) Cross-sectional composite OCT angiogram. The lesion is avascular. Overlying choroidal vasculature is thinned. Flow signals are color coded: purple, choroid; red, neuroretina.


OCT angiography: resulted in fewer choriocapillaris flow voids (between arrows).


Computed tomography at the first presentation showing a 5-cm massive pulmonary tumor in the left upper lobe and multiple nodules in both lung fields. Mediastinal window.


Computed tomography at the first presentation showing a 5-cm massive pulmonary tumor in the left upper lobe and multiple nodules in both lung fields. Pulmonary window.


(A) Histological examination of lung biopsy specimens obtained from the left pulmonary mass revealing proliferation of polyhedral and spindle atypical cells.


(B) PD-L1 tumor proportion score was detected by Burning Rock Dx.


Chest CT images obtained after one course of chemotherapy.


Chest CT images obtained after 2 weeks.


6 weeks.


10 weeks. In a patient who received single camrelizumab (PD1 monoclonal antibody) treatment.


The expression of EGFR2 was detected by IHC before.


After. Apatinib treatment. (100x).


Macroscopic features of the colon at autopsy. The serosal membrane showed patchy fibrous thickening, and the intestinal wall was edematous.


Preoperative neuroradiological assessment. Computed tomography scan (a) demonstrating the presence of a densely calcified left temporal and insular lesion.


Preoperative neuroradiological assessment. FLAIR sequences of magnetic resonance (MR) scan confirmed the presence of the calcified tumor (b).


Preoperative neuroradiological assessment. Postoperative MR confirmed the complete resection of the lesion (c).


Large expansile tumor mass with thinned out cortex in the anterior end of fourth rib noted on computed tomography scan.


Clinical photograph of patient before treatment (left-side view).


Clinical photograph of patient 6 weeks after treatment.


Computerized tomography scans before and after immunotherapy in Case #1 Initial CT scan showing large left sided renal mass in April of 2019.


Compared to CT scan in March of 2020. Showing substantially decreased mass.


Representative pathologic images from Case #1 Hematoxylin and eosin (H&E) stained slides at low-power.


High-power. Magnification showing extensive hyalinized fibrosis with scattered chronic inflammation and hemosiderin laden macrophages in the area of tumor regression.


The fibrosis extends into the adjacent fibroadipose tissue (C).


Chronic tubulointerstitial nephritis and globally sclerosed glomeruli are present in the adjacent residual benign renal parenchyma (D).


Computerized tomography scans before and after immunotherapy in Case #2 Initial CT scan in July of 2018 showing large right renal mass.


Pulmonary metastases.


Compared to CT scan in December of 2019 showing substantially decreased mass.


Resolution of pulmonary metastases.


Representative pathologic images from Case #2 H&E stained slides at low-power.


High-power. Magnification showing a massive infiltration of chronic inflammatory cells and foamy macrophages in the area of tumor regression.


Areas of tumor regression also showed necrotizing granulomatous inflammation (C).


Chronic tubulointerstitial nephritis, globally sclerosed glomeruli, and hemosiderin laden macrophages are present in the adjacent residual benign renal parenchyma (D).


Preoperative magnetic resonance imaging brain T2-weighted images.


(a and b) Postoperative computed tomography brain with contrast showing complete exision of lesion.


(a) Rhabdoid cells with vesicular nuclei, prominent nucleoli, and spherical cytoplasmic filamentous inclusions (H and E, x200). (b) Small hyperchromatic cells similar to PNET showing dense nuclei, dispersed chromatin, small to inconspicuous nucleoli, with scant cytoplasm and indistinct cell borders, arranged in a solid pattern (H and E).


(Buccal view): Buccal fistula.


(palatal view): Accentuated lingual pit of the right maxillary lateral incisor.


Intraoral periapical radiograph.


The gutta-percha cone inserted in oral fistula.


Fistulography.


Identification of the dens invaginatus invagination orifice.


Dens invaginatus with a rounded shape surrounded by vital pulp of maxillary lateral incisor.


Entrance of the dental root canal.


Seal of the peri-malformation space and of the canal tract of dental malformation.


Periapical radiography at the end of endodontic treatment.


Periapical radiography after 6 months of endodontic treatment.


Cervical gingivoplasty.


Lithium silicate ceramic veneers on 1.2 and a reductive odontoplasty of the right maxillary central incisor.


Mean fluorescence intensity values of untreated and acid-treated single antigen bead assay from a control sample.


Mean fluorescence intensity values of untreated and acid-treated single antigen bead assay from the test sample.


Gray-scale ultrasound image shows a well-circumscribed nodule.


Axial T1 -weighted MR image at the level of the nipple demonstrates a small, well circumscribed nodule lateral to left nipple of intermediate signal.


Dynamic, fat saturated magnetic resonance performed immediately after intravenous contrast administration at the same level as Figure 2 demonstrates avid enhancement of the lesion lateral to the left nipple.


Hematoxylin and Eosin stained tissue at x40 low power view shows hemangioma (black arrows) and breast ducts and lobules (gray arrows).


Hematoxylin and Eosin stained tissue at x400 high power view reveals abnormal vascular spaces in the hemangioma (arrows).


This is a dynamic enhancement curve mapping lesion enhancement with time following contrast administration. It shows rapid initial enhancement, a peak, minor washout and then a plateau formation. This is an intermediate type of curve - malignant lesions have the rapid enhancement but also tend to washout rapidly as well - ie there is steeper curve drop as compared to what is seen in this image.


Chest X-ray showing right-sided moderate effusion with thickening.


Medical thoracoscopy view, showing inflamed parietal pleura with few adhesions.


Microscopic view showing acute fibrinous exudate (H&E x 200).


Microscopic view revealing dense fibroblastic reaction characterized by fascicles of spindle cells mixed with fewer numbers of lymphocytes, plasma cells, and eosinophils associated with deposits of dense collagen (H&E x 200).


Axial CT scan of the abdomen in case 1 with intravenous contrast revealing a complex 2.3 cm pancreatic head lesion (arrow). CT, computed tomography.


H&E-stained sections of UCOGC. (A) Low-power view demonstrating a fairly well-circumscribed tumor nodule surrounded by a rim of desmoplastic stroma (arrow), which abuts adjacent benign pancreas. Hemorrhage is observed within the tumor (arrow), 20x.


H&E-stained sections of UCOGC. (B) Central hemorrhage and necrosis give the appearance of a condensation of hyperchromatic nuclei toward the periphery of the nodule, 100x.


H&E-stained sections of UCOGC. (C) Multiple mitotic figures, including one bizarre pentapolar mitosis (arrow), are observed within a background of multinucleated giant cells and microscopic hemorrhage. Malignant cells demonstrate marked nuclear pleomorphism and hyperchromasia, 200x.


H&E-stained sections of UCOGC. (D) High-power view demonstrating an additional atypical mitotic figure surrounded by multinucleated giant cells (arrows) with a dense cytoplasm. Over 20 distinct nuclei can be observed within a single cell, 400x. H&E, hematoxylin and eosin; UCOGC, undifferentiated carcinoma with osteoclast-like giant cells.


Axial CT scan of the abdomen in case 2 with intravenous contrast showing an ill-defined pancreatic head mass (arrow) that measures 3.6 x 3.6 cm. There is associated pancreatic ductal dilatation with abrupt cutoff at the level of the mass. The mass abuts the superior mesenteric vein and there is attenuation of the main portal vein and SMV at the confluence related to the mass. SMV, superior mesenteric vein.


H&E-stained sections demonstrating clear cell features. (A) Low-power view demonstrating irregular malignant glands with surrounding desmoplastic tumor stroma. The normal lobular architecture of the pancreas is lost, 5x.


H&E-stained sections demonstrating clear cell features. (B) Angulated malignant glands are lined by epithelial cells with hyperchromatic basal to central nuclei of varying sizes and variable amounts of foamy to clear cytoplasm (arrows). Single malignant cells are present within the stroma, 100x.


H&E-stained sections demonstrating clear cell features. (C) Malignant cells are seen invading between an arteriole (black arrow), a nerve (white arrow), and adjacent benign pancreas (asterisk), 100x.


H&E-stained sections demonstrating clear cell features. (D) Similar histopathologic findings are observed in metastatic tumor glands seen in the subcapsular sinus of a peripancreatic lymph node (arrow), 100x.


Plain radiograph of wrist showing lytic lesion in Capitate.


CT Scan wrist showing lytic lesion in Capitate.


Intra operative picture showing cavity in Capitate after extended curettage of the lesion.


Histopathalogical photomicrograph showing multinucleated giant cell (arrow).


1 year follow up radiograph showing no recurrence.


Frond-like structures with a vascular core making pseudopapillary pattern of growth Follicle-like spaces with variability in size and content, Distinct cytologic features; polygonal cells with clear cytoplasm and round to angulated nuclei with prominent 1-2 nucleoli.


Immunoreactivity with CD117, PLAP and CK AE1/AE3.


Noncontrast computed tomography scan of the chest showing a 2 cm round soft tissue mass with smooth regular margin in the left lower lobe.


Fibrotic stromal fragment with papillary features in a background of abundant blood (Papanicolaou stain, x100).


Fibrovascular fragment associated with round cells (Diff-Quik stain, x200).


Cohesive sheets of surface cells arranged in pavement-like fashion (Diff-Quik stain, x400).


Dense collagenous stromal tissue associated with bland appearing round cells (x200).


Both surface and round cells are positive for thyroid transcription factor-1 immunostain (x200).


AE1/AE3 immunoreactivity is present in the surface cells but not the round cells (x200).


Progesterone receptor immunoreactivity is present in the round cells but not the surface cells (x200).


Bosselated irregular non-tender skin colored swelling over the occipital region extending toward the nape of the neck.


Coronal view T1 DIXON FS post gadolinium, slice thickness 3 mm. Arrow: Cavernous sinus, Triangle: Pars cavernosa of the internal carotid artery. Initial MRI: Thrombosis of the cavernous sinus and involvement of the internal carotid artery with hyperemia of the vasa vasorum (A).


Coronal view T1 DIXON FS post gadolinium, slice thickness 3 mm. Arrow: Cavernous sinus, Triangle: Pars cavernosa of the internal carotid artery. MRI 7 days post-admission: Increasing inflammation of the internal carotid artery with further reduction in lumen size (B).


Coronal view T1 DIXON FS post gadolinium, slice thickness 3 mm. Arrow: Cavernous sinus, Triangle: Pars cavernosa of the internal carotid artery. MRI 14 days post-admission: Improvement of internal carotid artery involvement with a partial recovery in size (C).


Coronal view T1 DIXON FS post gadolinium, slice thickness 3 mm. Arrow: Cavernous sinus, Triangle: Pars cavernosa of the internal carotid artery. MRI 3 months post-admission: Complete recanalization of the left cavernous sinus and normal size of the left internal carotid artery (D).


Neuroradiological findings on presentation. Brain CT showing enlarged lateral ventricles with slit ventricle.


Neuroradiological findings on presentation.abdominal and pelvic CT demonstrating the course of the ventriculo-peritoneal shunt catheter (arrows) and the massive cerebrospinal pseudocyst surrounding the peritoneal end.


CT after insertion of the ventriculo-pleural shunt. Brain CT showing decreased lateral ventricle volume (a, b).


T1W Magnetic resonance imaging showing a predominantly isointense intramedullary tumor.


Sagittal.


Axial. Contrast enhanced Magnetic resonance imaging showing the homogenously enhancing intramedullary tumor with interspersed cystic/necrotic areas.


Microphotograph showing a highly cellular tumor, consisting mainly of small round to oval cells with hyperchromatic nuclei and remarkably scanty cytoplasm along with the presence of Homer-Wright pseudorosettes; the tumor cells being immunopositive for CD 99 (inset).


Photograph showing a nodular swelling over right lower eyelid.


Photomicrograph showing cellular smear with tumor cells arranged in groups as well as singly scattered (MGG, x100).


Pleomorphic tumor cells with vacuolated cytoplasm (MGG, x400).


An extensive erosive erythema with a red, easy-to-bleed nodule on the scrotum (a).


Atypical cells mainly proliferated in the dermis forming solid pattern nests (b).


Paraffin-embedded tissue samples from the right shoulder were deparaffinized and stained with anti-RANKL antibody (c).


T1-weighted MRI before the treatment (a).


Physical examination revealed that all primary tumors had disappeared (b).


T1-weighted MRI after the treatment (c).


Lymphocyte count, cytomegalovirus (CMV) blood and cerebrospinal fluid (CSF) viral load, and the progression of symptoms and events over one year, in a 10-year-old girl who underwent allogeneic HSCT. Colour bars represent the timeline graph of antiviral treatments and their corresponding duration. After discontinuing the immune-suppressive regimen, the patient first experienced headaches with high blood CMV load, despite therapy with valganciclovir and foscarnet. Her symptoms then worsened until overt immune reconstitution inflammatory syndrome (IRIS) occurred, with high CSF CMV load, despite CMV clearance from the blood, together with an increase in lymphocyte count and severe bone marrow and renal toxicity. After the initiation of anti-CMV-specific immune globulins, the CSF viral load dropped rapidly, and symptoms improved. HSCT, hematopoietic stem cell transplantation; IST, immunosuppressive therapy; IRIS, immune reconstitution inflammatory syndrome; CMV, cytomegalovirus; CSF, cerebrospinal fluid.


Serum and cerebrospinal fluid (CSF) cytomegalovirus (CMV)-IgG antibodies (Ab) titre evaluation in CMV-IgG-positive patients undergoing the Cytotect CP treatment (Cytotect group, n = 15) and those not so treated (Control group, n = 15). In the Cytotect group, the CSF CMV Ab levels were significantly higher than serum Ab levels (P < 0.001) and CSF Ab levels of the Control group (P < 0.0001). CMV serum and CSF Ab evaluations were performed in triplicates, and their results are shown as mean +- SD. Statistical analysis was performed using the Mann-Whitney U-test.


First visit occlusal view.


After 6-month placement of calcium hydroxide.


After 20 months of calcium hydroxide placement.


CBCT view;. First visit.


After 6 months, Significant shrinkage in the size of the lesion was observed.


After 20 months of follow-up.


Initial evaluation of mixed friction burn to anterior abdomen of a 30-year old female pedestrain struck by a motor vehicle. Total burn surface area (TBSA) estimated to be 13% (4% full-thickness 3rd degree, 9% partial thickness 2nd degree).


Morel-Lavallee lesion discovery during of a 30-year old female pedestrain struck by a motor vehicle tangential burn wound excision revealed full-thickness abdominal wall ischemia (approximately 12 cm diameter), extensive fascial-cutaneous separation, and traumatic dissection. Over 1.5 L of fluid were removed from this region at index operation requiring drain placement for weeks post-operation.


Post-repair day 5 of abdominal wall Morel-Lavallee lesion with excision and autografting with split-thickness skin graft of a 30-year old female pedestrain struck by a motor vehicle.


Clinical course of the present case before HBV reactivation.


Clinical course of the present case after anti-virus therapy started. GCAP = Granulocytapheresis.


Microtia with preauricular tag.


Facial asymmetry with left preaxial polydactyly.


Fundus photography of the right and left eyes. Extensive choroidal coloboma is seen in the right eye.


Fundus photography of the right and left eyes. , markedly different from the left eye.


Fluorescein fundus angiography of the right and left eyes. A; The right eye shows no changes of DR.


Fluorescein fundus angiography of the right and left eyes. B; The left eye displays a wide area of retinal nonperfusion.


Imaging of hepatic PEComa. (A) Contrast-enhanced phase of CT reveals a poorly-defined mass with a significantly high intensity in segment VII of the liver.


Immunohistochemical results of hepatic PEComa (x200). (A) Tumor cells showing strong and diffuse positive staining for HMB-45.


Immunohistochemical results of hepatic PEComa (x200). (B) Tumor cells showing strong and diffuse positive staining for SMA (+++). PEComa, perivascular epithelioid cell tumor; HMB-45, human melanoma black-45; SMA, smooth muscle actin.


Dissection of the tumor.


Distal pancreatectomy using a stapler.


The spherical tumor after complete separation.


Operative bed with pancreatic stump.


Preoperative extraoral profile.


Preoperative intraoral image.


Computed tomography scan (axial cut).


Computed tomography scan (coronal cut).


Intraoperative image.


Postoperative extraoral profile.


Microscopic view showing dense proliferation of fibro-collagenous tissue among which are seen areas of bony trabeculae lined by plump osteoblasts.


Proliferating fibroblastic tissue with blood vessels and osteoid showing plump osteoblastic rimming.


High-power view showing focus of proliferating fibroblastic cells with few specs of calcification (psammamatoid type).


Fundus images at presentation (2a), after 1 month (2b), and at 4 months (2c). Faint discolored peripapillary fundus lesions typical of multiple evanescent white dot syndrome (MEWDS) were seen at presentation (2a) and still present after one month (2b); corresponding to fluorescein angiography (FA) hyperfluorescent areas and hyperautofluorescent areas. At 4 months (2c), these lesions take the aspect of chorioretinal scars while FA and hyperautofluorescent lesions are no longer present.


Fundus autofluorescence pictures at presentation (5a), after 1 month (5b), and at 4 months (5c). On the right column (left eye), hyper-autofluorescent areas corresponding to FA and ICGA lesions can be seen at presentation (5a) which, on the middle picture, slightly progressed after one month (5b) with return to normal at 4 months (5c).


Second episode of choriocapillaritis consistent with multifocal choroiditis. Fundus images (7a) show chorioretinal scars nasal to the optic disc. Both fundus autofluorescence (7b) and fluorescein angiography (7c) show only faint lesions, while on indocyanine green angiography, hypofluorescence is substantial (7d), but resolves one month after periocular triamcinolone injection (7e) in parallel with recovery of the visual field (see figure 1).


Lateral condylar hypoplasia with lateralisation of patellae (with a predominance on the left side) - flexion.


Lateral condylar hypoplasia with lateralisation of patellae - AP/Long Leg Views.


Pathology of the masses of the transplanted kidney, and gross photograph of the allograft nephrectomy specimen. Periodic acid-Schiff staining and Grocott methenamine silver staining of renal mass at 100 x ,at 1.


Pathology of the masses of the transplanted kidney, and gross photograph of the allograft nephrectomy specimen. 000 x. Show granuloma caused by Cryptococcus (arrows).


Pathology of the masses of the transplanted kidney, and gross photograph of the allograft nephrectomy specimen. Electron microscopy of renal mass (E) shows the Cryptococcus (arrow).


Pathology of the masses of the transplanted kidney, and gross photograph of the allograft nephrectomy specimen. (F) Renal cryptococcoma (black arrow) and enlarged renal crptococcoma (white arrow).


Coronal preoperative MRCP/MRI in patient 1 revealing pancreas divisum with a lobulated cyst lesion in the uncinate process as well as a notable dilation of the uncinate duct. Scattered benign hepatic cysts are noted, with a normal sized bile duct. MRCP, magnetic resonance cholangiopancreatoscopy.


Coronal preoperative MRI in patient 2 revealing pancreas divisum with a cyst lesion measuring 7.3 cm involving the uncinate process and duct of Wirsung. Of note, mural nodularity is appreciated.


(A) Liver metastases detected using magnetic resonance imaging (MRI) in November 2019.


(B) Response of liver metastases detected using MRI in January 2020 after treatment with etoposide combined with cisplatin and continued ADT plus pembrolizumab. Metastases are indicated by red arrows.


(C) Clivus and adjacent right sphenoid bone metastases detected by MRI in April 2020.


(D) Meningeal clivus and adjacent right sphenoid metastases in November 2020. Metastases are indicated by red arrows.


The altered landscape and phylogenetic reconstruction of the two samples. (A) The second panel shows the cancer cell fraction estimated by using PyClone and calculated using the read depth of mutations, copy numbers, and purity of tumors. Other panels are showing the frequency of mutations in three types of prostate cancer using public data from the cBioPortal (1400 primary tumors, 54 NEPC samples, and 880 mCRPC samples). Important functional cancer genes are marked in red.


The altered landscape and phylogenetic reconstruction of the two samples. (B) Overview of copy number alterations and cancer genes encompassed in segments are shown in red.


The altered landscape and phylogenetic reconstruction of the two samples. (C, D) Fishplot indicating the dynamic clonal progression of the tumor, and clonal evolution tree showing the phylogenetic relationship between the two samples.


Selected sagittal.


Axial.


Coronal. Slices of CT, PET, and ,fusion images.


MIP image. Of PET-CT showing increased focal FDG uptake in the subcutaneous fatty tissue posterior to the proximal gluteal muscle planes at right thigh.


Typical vimentin positivity in the renal cell carcinoma cells (Vimentin Antibody, x100).


Malignant clear cell infiltration in the fibroadipose tissues, with vascular tumor embolus adjacent to the tumor (Hematoxylen and eosin, x40).


MIP image. Of PET-CT showing increased focal FDG uptake at the posteromedial part of proximal third of right cruris.


MRI shows a soft tissue lesion in the intermuscular area, with a diameter of 2.5 cm, which is hypointense on T1-weighted images.


Hyperintense on T2-weighted images. And showing intense contrast enhancement.


Fine-needle aspiration, left leg, Diff-Quik (x200), showing a cellular yield of cohesive, three-dimensional tumor clusters with cellular overlapping and architectural disorder.


Fine-needle aspiration, left leg, Diff-Quik (x400), columnar tumor cells arranged in glandular configuration with elongated nuclei, mild to moderate nuclear pleomorphism, and finely dispersed chromatin.


Contrast-enhanced CT imaging demonstrating no cirrhotic changes prior to 90Y administration.


Generalized mottled changes compatible with postembolization edema 3 months after 90Y administration.


The patient subsequently developed a large, nonenhancing, complex cystic central hepatic lesion suggestive of a post-90Y biloma 14 months after administration.


Over the subsequent 45 months developed a progressively irregular texture suggestive of hepatic cirrhosis.


Needle core biopsy of the liver taken 47 months after 90Y administration. A; There is a large band of chronically inflamed fibrous tissue, highly suggestive of cirrhosis. HE. X10.


Needle core biopsy of the liver taken 47 months after 90Y administration. B; This is highlighted by Masson trichrome staining, demonstrating chronically inflamed fibrous tissue (blue), highly suggestive of cirrhosis.


Needle core biopsy of the liver taken 47 months after 90Y administration. X10. C; The nonfibrotic liver showed macrovesicular steatosis with mildly active steatohepatitis. HE. X40.


Needle core biopsy of the liver taken 47 months after 90Y administration. D; On the other hand, sinusoidal Kupffer cells showed a mild degree of hemosiderosis. Perls iron stain. X40.


(A) Intraoral view of the upper right quadrant at baseline; calculus and gum bleeding is visible.


(B) Intraoral view of the frontal lower teeth at baseline; small amounts of calculus and pus discharge are visible.


Panoramic radiograph at baseline.


(A) Upper right quadrant after antibiotic therapy.


(B) Frontal lower teeth after antibiotic therapy.


Intraoral view of the frontal lower teeth 14 days after SRP and splinting.


Intraoral view 6 months after SRP.


Panoramic radiograph 6 months after SRP: tooth #43 showed an extensive periapical lesion with well-defined borders and bone loss extruding onto the root's mesial surface.


Walking" probing of the periodontal pocket using a Naber periodontal probe. Distal buccal point.


Walking" probing of the periodontal pocket using a Naber periodontal probe. Middle buccal point.


Walking" probing of the periodontal pocket using a Naber periodontal probe. Mesial buccal point , all measurements are 2 mm probing depth.


Walking" probing of the periodontal pocket using a Naber periodontal probe. (D) Narrow and deep 8 mm periodontal pocket on the mesial tooth surface.


(A) No bleeding was observed immediately after endodontic access opening.


(B) Instrumentation of the root canal using an iRace rotary endodontic instrument.


(C) Passive ultrasound irrigation with an ultrasound tip.


(D) Treating the root canal with ozone gas.


(A) Working length confirmation.


(B) Immediately after obturation.


(C) Six-month follow-up showing complete healing of the bone defect in the periapical area and interdental septum.


Prozone ozone generator.


GTG-banding revealed a complex karyotype multiple numerical and or structural rearrangements.


Pathology of Solid Pseudo-Papillary Tumor of the Pancreas.


A preoperative photograph revealed total hairy scalp and forehead avulsion with only a connection in the nuchal area.


The intraoperative and postoperative indocyanine green angiography (ICGA) mapping results. A; Intraoperative ICGA mapping with SPY-Q analysis of perfusion in the replanted scalp. Asterisk represents the left temporal area that is automatically selected as a reference with a 100% perfusion value. Areas with 25% perfusion relative to the maximal perfusion reference were traced with blue lines. Areas confined by the blue lines represent well-perfused tissue with more than 25% of the reference area perfusion.


The intraoperative and postoperative indocyanine green angiography (ICGA) mapping results. B; The color reversal version of ICGA image when the necrotic area became mature. Please note the hypoperfused frontoparietal area represented by the color white.


All skin grafts survived with acceptable cosmetic results at the 1-month follow-up.


Periodic acid Schiff (PAS) stain, 400x magnification, shows an enlarged glomerulus with deposits which are PAS negative and occasional PAS positive hyaline caps. Tubules and interstitium are normal.


Silver stain, 400x view shows deposits are silver negative.


Deposits were not congophilic.


Immuno-fluorescence stain: the deposits were negative for all IgG, IgM and complements.


Electron microscopic study of renal biopsy specimen fixed using gluteraldehyde, viewed under 40,000x magnification revealed abundant subendothelial deposits of large fibers (97nm in width) with long spacing striations suggestive of collagen fibers; confirming the diagnosis of collagenous glomerulopathy.


Kidney biopsy slide stained with hemotoxylin-eosin stain and periodic acid Schiff stain (PAS), viewed under 400x magnification shows an enlarged glomerulus with increased mesangial matrix and mesangial interposition with diffuse membrane thickening. Tubules and interstitium are normal.


Magnetic resonance imaging (MRI) showing a T1 T2 hypointense lesion in the right supraclavicular region which is diffusely infiltrating the adjacent soft tissue.


Contrast-enhanced CT of chest showing pericardial effusion (white arrow), bilateral pleural effusions and left-sided lung consolidation (red arrow).


Magnetic resonance imaging with diffusion sequence shows an important restriction of diffusion in the peripheral region.


Hematoxylin-eosin stain showing both tumor components and transition area (x2).


Average percentage of MGMT methylation.


Initial clinical presentation:clinical composite photograph of the patient's left eye reveals an extensive fleshy salmon solid tumor of the conjunctiva extending into the orbit inferonasally.


Histopathology from biopsied conjunctival lesion:photomicrograph reveals sheets of large neoplastic lymphoid cells with moderate nuclear pleomorphism, vesicular chromatin, and large nucleoli underlying normal epithelium. (H&E, 30X).


Immunohistochemical stains of conjunctival lesion:photomicrographs of multiple immunohistochemical assays showed that the large lymphoid cells stained strongly positive for CD20 and MUM-1; it was also positive for Pax-5 and weakly positive for Bcl-6. The large lymphoid cells were negative for CD10. The small background lymphocytes stained positive with CD3.


Patient's lesions.


Computed tomography scan (axial section) of thorax showing a large heterogeneously enhancing soft tissue mass lesion in the right perihilar region involving right lower lobe extending into the mediastinum with loss of fat planes with esophagus, aorta, and right crus of the diaphragm. There is no chest wall or pleural involvement.


Immunohistochemistry picture from lung lesion showing tumor cells positive for neuron specific enolase (x200).


Chest X-ray demonstrating multiple lung metastases of sarcoma and a metastasis to the right pleura and left hemopneumothorax.


Chest X-ray demonstrating multiple lung metastases of sarcoma and bilateral pneumothorax.


A pair of neoplastic cells (upper left) shows scant cytoplasm, irregular nuclear contours, visible small nucleoli, and a possible inter-cellular 'window'. The cytoplasmic eosinophilia of the neoplastic cells contrast with the cytoplasmic basophilia of the larger reactive mesothelial cell (lower right) (Wright stain, x1000).


Cellular smear showing branching papillary fronds (Pap, x100).


Cells have round to oval nuclei with fine granular chromatin and have nuclear grooves (Pap, x400).


Facial features and limb malformations of the fetus in case 1. A 28-year-old Chinese woman was referred for prenatal diagnosis at 16 weeks of gestation due to fetal nuchal translucency (NT) thickening (A).


Facial features and limb malformations of the fetus in case 1. The pregnancy was terminated at 20 weeks, and autopsy showed distinct facial features . Limb defects.


Facial features and limb malformations of the fetus in case 1. The pregnancy was terminated at 20 weeks, and autopsy showed distinct facial features.


Facial features and limb malformations of the fetus in case 1. Limb defects.


Facial features and limb malformations of the fetus in case 1. . In the fetus as indicated by the arrows.


Clinical features of the proband and Sanger sequencing results in case 3. The proband.


Clinical features of the proband and Sanger sequencing results in case 3. II: 1) presented with typical facial features of Cornelia de Lange syndrome (CdLS) and upper limber defects.


Clinical features of the proband and Sanger sequencing results in case 3. The (F) panel shows the Sanger sequencing results of NIPBL c.448dupA mutation in the family.


Typical complex-branching pseudopapillary structures surrounded with single and/or loosely cohesive neoplastic cells (PAP, smear).


The clear vacuoles were often single but numerous clear vacuoles were also observed both in neoplastic groups and single, discohesive, plasmocytoid neoplastic cells (Diff-Quik, smears).


Small groups of cells with clear cell vacuoles in variable sized (Diff-Quik, smear).


Intracytoplasmic vacuoles are well defined like coin-shaped (Diff-Quik, smears).


Vacuoles can be seen often and easily in Diff-Quik stained smears (Diff-Quik, smears).


Neoplastic cells shows nuclear immuno reactivity with beta-catenin (cell block).


Strong cytoplasmic immuno reactivity with vimentin antibody (cell block).


CD10 also showed strong cytoplasmic immuno reactivity similar to vimentin (cell block).


ctDNA SMSEQ analysis of CSF. Blue box, expected ERBB2 (HER2) gene counts; black dot, ERBB2 gene counts (HER2 amplification) in the patient's CSF.


(d-f) Represent coronal computed tomography, positron emission tomography, and fused positron emission tomography/computed tomography images, respectively.


Histopathology of the lesion showing areas of laminated keratin with no foci of calcification or hemorrhage, confirming benign epidermoid cyst.


The gamma spectrum measurement of the contamination demonstrates an energy peak in 500-550 keV region (due to positron formation at 511 keV). The rectangular bar shows the energy window used for Co-57 marker in the superimposed image (Figure 3 on the right).


The top row (A1-G1) displays magnetic resonance (MR) images from the initial study during the first admission, and the bottom row (A2-G2) displays the corresponding images during the relapse 2 months later. The lesion (A1,A2) returns an isointense signal on T1-weighted images and (B1,B2) demonstrates enhancement on post-contrast images. (C2) High T2-signal cystic lesions are seen along the leptomeningeal surface that increased in size and number during the relapse. (D2) The internal signal of these cystic lesions is not entirely suppressed on fluid attenuation inversion recovery (FLAIR) sequence. (E1,E2) No blooming artifacts seen on gradient echo (GRE) sequence. (F1,G1;F2,G2) Restricted diffusion is not demonstrated in both studies.


The top row (A1-C1) displays MR images from the initial study during the first admission, and the bottom row (A2-C2) displays the corresponding images during the relapse 2 months later. (A1,A2) There were cystic lesions with high T2 signal along the leptomeningeal surface. These initially small non-enhancing cystic lesions [white arrows, (B1)] increased in size and number in the follow-up scan [white arrows, (B2)]. (A2) Brain tissue was seen herniating through a Burr hole from a previous external ventricular shunt site, indicating that there was increased intracranial pressure. (C1,C2) Coronal post-contrast T1 images demonstrate the predominantly basal cisternal location of the nodular leptomeningeal thickening.


MR spectroscopy (TE/TR = 144 ms/2,000 ms) findings of elevated choline:creatine ratio (4.34) suggesting high cell turnover in favor of malignancy. The absence of a singlet peak at 3.8 ppm makes tuberculoma less likely.


ML phylogeny of the O. anthropi 16S sequences deposited in GenBank. The results revealed that our 16S sequence 16S_B1 has the closest phylogenetic relationship with O. anthropi.


Preoperative clinical photographs showing intraoral swellings in the retromolar area on right side.


Preoperative clinical photographs showing intraoral swellings in the retromolar area on left side.


CT image showing bilateral expansile radiolucent lesion surrounding both the mandibular and maxillary third molar regions along with supernumerary teeth.


CT image shows maxillary radiolucent lesion surrounding the right impacted third molar.


CT image shows maxillary radiolucent lesion surrounding the left impacted third molar.


The coronal view of mandible in CT image shows bilateral lingual bone perforation.


Cystic fluid aspirate shows straw-colored fluid.


Histopathological section showing the cystic epithelial lining typically of dentigerous cyst.


Another histopathological section showing the cystic epithelial lining typically of dentigerous cyst.


Intraoperative clinical photograph showing resultant bony cavities after enucleation of dentigerous cysts in mandible.


Postoperative clinical photograph showing the gauze packed in to the bony cavities after cyst enucleation.


Intraoral clinical view after 6 months showing the healing of bony cavities.


Postoperative panoramic view after 5 months of enucleation showing significant amount of bone formation.


Chest CT scan- Axial view: Normal parenchymal lung tissue without evidence of active chest disease or intrathoracic lymphadenopathy.


(a) Abdomen and pelvis CT scan: The liver is large measuring up to 24 cm (blue arrows). The spleen is large measuring 17.4 cm (red arrows), retrocrural lymphadenopathy (white arrows).


(b) Abdomen and pelvis CT scan: Retroperitoneal lymph nodes (white arrows).


Gallium scan: Large region of intense focal uptake midline abdomen compatible with mesenteric (blue arrows) and retroperitoneal lymphadenopathy (white arrows). No abnormal lung uptake is seen.


Lymph node biopsy: (hematoxylin and eosin stain) lymphohistiocytic infiltrate (red arrows).


Lymph node biopsy: Many acid-fast bacilli (blue arrows).


Head MRI findings. There was no tumor in the pituitary gland (white arrow).


18F-FDG PET/CT scan of a 51-year-old Caucasian female with symptoms of central pontine myelinolysis. Scan is showing localized FDG uptake in the pons, with normal and symmetrical activity in the rest of the brain.


MR-scan T2-weighted image showing a hyperintensive region in the central part of pons. In addition, hyperintensive region was present symmetrically in the caput nucleus caudatus, putamen, and the lateral part of thalamus.


Upper image: T2 axial image of the lesion surrounding the catheter (red arrow). The granuloma appears as an extra-axial lesion isodense to the myelon. Lower image: T1 contrast sagittal image showing a space-occupying, ring-enhancing, inhomogeneous, extra-axial mass (red arrow) in the spinal canal at the level of T4.


T2 sagittal image of the same lesion with clearly visible extensive T2 signal changes in the spinal cord. The tip of the catheter is seen encased in the granuloma substance (red arrow).


T1 contrast imaging. Upper image: Axial image showing a large recurrence overshadowing and compressing the spinal cord (pink arrow). Lower image: The recurrent granuloma is seen here as a large, ring-enhancing, inhomogeneous, mass-causing high-grade compression of the spinal cord (pink arrow).


(a-c) Multiple nodulo-papular, ulcerated lesions in gingiva involving the entire mandibular arch, gingiva of left posterior maxillary arch in relation to the premolars and molars along with similar lesions in the posterosuperior aspect of the left buccal mucosa (yellow arrows).


Orthopantomogram showing severe generalized irregular alveolar bone destruction in the entire mandibular and in the left posterior maxillary alveolar ridge region.


(a) The presence of sheet-like proliferation of Langerhans cells, having coffee bean-shaped appearance, eosinophils, and plasma cells (H and E, x100). (b) Langerhans cells exhibiting positivity for anti-CD1a (x40).


Necrosis of the frontal region of the mandibular alveolar ridge and three missing incisors.


Magnetic resonance imaging of the girl's mandible (T1 TSE fat sat contrast medium sequence) showed areas of bone necrosis (star) with peripheral reactive bone contrast enhancement (arrows) and enhancement of the soft tissue edema (arrowheads).


Histopathology of the biopsy specimens taken from the lower jaw (first biopsy). (a) Inflamed gingival mucosa with superficial erosions, with granulation tissue and dystrophic calcifications. Retrospectively, calcifications were "reinterpreted" as remains of destructed alveolar bone. HE, original magnification, x4.


Histopathology of the biopsy specimens taken from the lower jaw (first biopsy). (b) Recanalization of the small vessels in the inflamed gingival mucosa (mark). Note the intense mixed inflammatory infiltrate in the background and the swollen endothelial cells. HE, original magnification, x20.


Total colonoscopy revealed a lesion in the rectum below the peritoneal reflection (4 cm above the anal verge).


A colonic pull-through segment of about 10 cm was left outside the anal canal without any tension and was fixed by sutures under indocyanine green fluorescence imaging.


Final coloanal anastomosis was performed without diverting the stoma under indocyanine green fluorescence imaging.


Diffuse enlargement and ulceration of labial gingiva.


Enlargement and ulceration of palatal mucosa.


Intra oral peri apical radiograph.


Infiltrated placard with alopecia, telangiectasias and squames located on the scalp.


Infiltrated placards with telangiectasias and squames located on the trunk.


Infiltrated plaques with telangiectasias and squames located on the lower limbs.


Diffuse granulomatous panniculitis and dermatitis, mainly comprised of epithelioid histiocytes and multinucleated giant cells, some with vacuolated cytoplasm, others with a large number of nuclei or with bizarre, triangular shapes, punctuated by collections of lymph and plasma cells; HEx40.


IHC: CD3 stains the small lymphocytes spread within the granulomatous infiltrate; x100.


Left picture shows the frontal view of the patient showing microcephaly, prominent nose (wide bridge, broad root, columella under ala nasi), Middle picture shows Oligodontia, Right picture shows the Generalized brachydactyly (A written consent was obtained from the patient's parents to publish this image).


Histological and immunophenotypic results of excisional biopsy of left cervical lymph node. Hematoxylin and eosin (H&E)-stained sections is seen (A).


Histological and immunophenotypic results of excisional biopsy of left cervical lymph node. Immunohistochemical staining of these specimens shows that the infiltrated lymphocytes are positive for CD20.


Histological and immunophenotypic results of excisional biopsy of left cervical lymph node. , CD21.


Histological and immunophenotypic results of excisional biopsy of left cervical lymph node. Of follicular dendritic cells, and EBER (magnification x20).


Histological and immunophenotypic results of excisional biopsy of the axillary lymph node and peripheral blood smear. H&E-stained sections is seen.


Histological and immunophenotypic results of excisional biopsy of the axillary lymph node and peripheral blood smear. Immunohistochemical staining of the specimens shows that the diffuse infiltrated lymphocytes are positive for CD20.


Histological and immunophenotypic results of excisional biopsy of the axillary lymph node and peripheral blood smear. EBER. (magnification x20).


Histological and immunophenotypic results of excisional biopsy of the axillary lymph node and peripheral blood smear. Wright's staining of peripheral blood smear showed typical atypical lymphocytes (D) (magnification x400).


Preoperative CT scans showing a large tumor in the nasopharynx. (A) Head CT image showing dense mass of nasopharyngeal soft tissue, protruding into the cavity, with regular shape and uniform density. The left eustachian tube and pharyngeal orifice are not visible, while the right pharyngeal crypt appears shallow.


Preoperative CT scans showing a large tumor in the nasopharynx. (B) Nasopharyngeal CT scan showing a mass-like shadow on the posterior lateral wall of the left nasopharyngeal roof.


Preoperative CT scans showing a large tumor in the nasopharynx. The enhanced scan image showing uneven density in the arterial phase (C).


Preoperative CT scans showing a large tumor in the nasopharynx. Areas with intense dye uptake in the venous phase, and small patchy low-density shadows (D).


Preoperative CT scans showing a large tumor in the nasopharynx. Postoperative head CT showing that the tumor is completely resected (E).


Microphotographs showing the histopathological features of the tumor. (A) Dense areas with cellular proliferation alternating with hypocellular areas (H&E; x40).


Microphotographs showing the histopathological features of the tumor. (B) Area of the tumor showing disorganized cellular arrangement (H&E; x40).


Microphotographs showing the histopathological features of the tumor. (C) Area with tumor cells arranged in stripes (H&E; x100).


Microphotographs showing the histopathological features of the tumor. (D) Area with tumor cells arranged in storiform pattern (H&E; x100).


Microphotographs showing the histopathological features of the tumor. (E) Multinucleated giant cells deposited in a myxoid stroma (H&E; x100).


Microphotographs showing the histopathological features of the tumor. (F) Multinucleated giant cells deposited in a hyaline stroma (H&E; x200).


Microphotographs showing the histopathological features of the tumor. (G) Interstitial vessels with hyaline degeneration (H&E; x100).


Microphotographs showing the histopathological features of the tumor. (H) Hypercellular areas showing fusiform or oval cells, with no apparent atypia, few cytoplasm, large and deep stained nuclei, and oval nuclei as well as some vacuolated nuclei and some tumor cells with nucleoli. Mitotic figures were 2 per 50 high-power fields (H&E; x400).


Microphotographs showing the histopathological features of the tumor. (I) Multinucleated giant cells varying in size and shape showing nuclei nested in the cytoplasm in a wreath-like and lobulated-shape (H&E; x400).


Micrographs showing characteristics of tumor stroma (A) Area showing tumor cells arranged in a wavy pattern (H&E; x40).


(B) Area showing apparent myxoid degeneration in the stroma (H&E; x40).


(C) Multinucleated giant cells with deep nuclear stains within the pseudovascular space (H&E; x200).


(D) Multinucleated giant cells distributed among the spindle tumor cells and the collagenous stroma (H&E; x200).


Immunohistochemical analysis of the tumor. (A) IHC image showing cells with diffuse CD34 positivity (original magnification x200).


Immunohistochemical analysis of the tumor. (B) IHC staining for BCL-2 showing diffuse membrane and cytoplasm positivity (original magnification x200).


Immunohistochemical analysis of the tumor. (C) Tumor cells showing diffuse membrane positivity for CD99 (original magnification x200).


Immunohistochemical analysis of the tumor. (D) IHC of STAT6 showing partially flaky nuclear positivity (original magnification x200).


Immunohistochemical analysis of the tumor. (E) IHC of CD68 showing partial cytoplasm positivity in giant cells (original magnification x200).


Immunohistochemical analysis of the tumor. (F) IHC for Ki-67 showing some positively stained cells (labeling index of 3%) (original magnification x200).


Short-tau inversion recovery hyperintensity.


T1 hypointensity involving the L4 vertebral body including the pedicles and the lamina (arrow).


(a-c) Computed tomography-guided left sided transpedicular biopsy of L4 vertebral body.


Histopathological images of the computed tomography-guided biopsy from L4 vertebrae,. X40.


X20 H, and ,E stained image - showing bony trabeculae infiltrated by neoplastic cells having hyperchromatic nuclei.


Medical image.


X20 immunohistochemistry image - tumor cells show GATA 3 positivity.


(Axial view) Computed tomography scan shows left side huge psoas hematoma (arrow).


(a-d) Sequential images of computed tomography angiography were suggestive of breech in the left lumbar segmental vessel at L4 level (arrow).


Transcatheter selective embolization at the left L4 segmental vessel (arrow).


17-year-old female with pain in the left heel diagnosed as due to an aneurysmal bone cyst. Lateral X-ray of the left foot shows radiolucent lesion (arrow) leading to expansion on the postero-lateral part of the calcaneus.


17-year-old female with pain in the left heel diagnosed due an aneurysmal bone cyst. MRI on the postero-lateral part of the calcaneus shows a cystic mass lesion in the medullary cavity. T1W.


17-year-old female with pain in the left heel diagnosed due an aneurysmal bone cyst. MRI on the postero-lateral part of the calcaneus shows a cystic mass lesion in the medullary cavity. T2W sequences show heterogeneous hyperintense sclerotic rim (red arrow) surrounding the medullar component and central heterogeneous hyperintense septae formations (green arrow). T2W sequence shows blood level components (blue arrow).


17-year-old female with pain in the left heel diagnosed due an aneurysmal bone cyst. MRI on the postero-lateral part of the calcaneus shows a cystic mass lesion in the medullary cavity. C) Image following intravenous contrast media administration shows contrast enhancement surrounding the lesion (red arrow) and in the septae formations (blue arrow).


Computed tomography chest before bronchoscopy demonstrating widespread airspace disease in the lower lobes bilaterally without volume loss, air bronchograms, or cavitation.


Computed tomography chest showing cavitation in the right lower lobe with an air-fluid level that measures 2.6 cm x 3.2 cm, highly suggestive of lung abscess.


A diffuse ill-defined movable bluish red swelling on right alveolar mucosa in the molar region.


Orthopantograph revealed no significant bony changes.


Fine-needle aspiration cytology stained smear showed well-delineated, tightly cohesive clusters of basaloid cells surrounding mucoid, hyaline globules.


Photomicrograph revealed multiple pseudocystic spaces of variable sizes filled with eosinophilic material.


Bone window.


Noncontrast.


Postcontrast. CT brain.


T1 FLAIR pre.


Postgadolinium.


Medical image.


Intraoperative photograph of the tumour breaching dura.


The tumour had extended through the skull.


Hematoxylin, and ,eosin stain (high-power view).


Hematoxylin and eosin stain (low-power view).


PAS positive.


FLI-1 positive.


MIC-2 positive.


Ki67 30% positive by visual estimation.


Brain imaging and immunohistochemical results. (A) Rapid progressive damage in the bilateral basal ganglia. Upper: Right basal ganglia lesion with patchy abnormal signals before admission. Lower: The bilateral basal ganglia showed patchy abnormal signals after admission. Bilateral basal ganglia lesions with hemorrhage on the right side.


Brain imaging and immunohistochemical results. (B) Mixed density shadow in the bilateral basal ganglia with peripheral parenchymal edema and postoperative resection of right basal ganglia lesions.


Brain imaging and immunohistochemical results. (C) Pathological results from the brain tissues of lesions in the right basal ganglia. Hematoxylin-eosin staining. Fungal spores and hyphae were observed in a small amount of necrotic brain tissue.


EML4-ALK fusion in the present case visualized using the Integrative Genomics Viewer (IGV). Diagrammatic sketch of EML4-ALK fusion result (A).


EML4-ALK fusion in the present case visualized using the Integrative Genomics Viewer (IGV). The IGV display of EML4-ALK fusion in an adenocarcinoma specimen of EML4-ALK fusion results (B).


EML4-ALK fusion in the present case visualized using the Integrative Genomics Viewer (IGV). The IGV display of EML4-ALK fusion in a squamous cell carcinoma specimen of EML4-ALK fusion results (C).


A; Fine needle aspirate showing small lymphocytes, scattered pigmented and nonpigmented cells, and proteinaceous material (cell block HE; magnification x1,000).


B; Immunohistochemical stain showing CD20 B lymphocytes (magnification x1,000).


C; Immunohistochemical stain showing few CD3 T lymphocytes (magnification x1,000).


Initial MRI of the brain with and without contrast. . A large right frontal lobe intra-axial mass with mass effect upon the right ventricular system and a leftward midline shift of approximately 1.3 cm is shown.


Hematoxylin and eosin staining of the tumor.


Synaptophysin immunohistochemical staining of the tumor typical of PNET.


Post-treatment MRI of the brain with and without contrast. . Postoperative changes in the right frontotemporoparietal region are shown. Irregular enhancement at the surgical site extends to the walls of the right lateral ventricle. This was unchanged in subsequent MRI scans.


52-year-old man with silicone-induced penile sclerosing lipogranuloma. (a) Sagittal T2-weighted image of the penis demonstrates heterogeneous lesion, with ill-defined margins surrounding the penis. The mass (arrowheads) was mainly of low signal intensity on T2-weighted images, a finding suggestive of the presence of fibrous tissue. Corpora cavernosa are intact (long arrow). Image shows normal right testis (asterisk).


52-year-old man with silicone-induced penile sclerosing lipogranuloma. (b) Transverse apparent diffusion coefficient map (b = 900 mm2/s) shows heterogeneous mass (arrow) surrounding the penile shaft. The lesion appears mainly isointense when compared to the normal corpora cavernosa (long arrow). The apparent diffusion coefficient value of the mass was 1.53 x 10-3 mm2/s (right corpus cavernosum: 1.49 x 10-3 mm2/s; left corpus cavernosum: 1.60 x 10-3 mm2/s). Normal left testis (arrow).


52-year-old man with silicone-induced penile sclerosing lipogranuloma. Transverse three-dimensional gradient-echo images acquired. Without.


52-year-old man with silicone-induced penile sclerosing lipogranuloma. With the application of the magnetization transfers pulse. The magnetization transfer signal of the mass lesion (arrowhead) was qualitatively lower than that of the corpora cavernosa (arrow). The magnetization transfer ratio (in percent) of the lesion was 67.


52-year-old man with silicone-induced penile sclerosing lipogranuloma. (e) Time-signal intensity curve of the lesion shows an initial upstroke after which the signal intensity gradually increases in the late contrast-enhanced phase.


52-year-old man with silicone-induced penile sclerosing lipogranuloma. Histopathologic evaluation of the excised tissue reveals vacuoles of variable size in the dermis corresponding to exogeneous substance. Multinucleated giant cells and abundant fibrosis is seen around the vacuoles (Hematoxylin and Eosin stain, magnification x20).


Ultrasound findings revealed that the intrascrotal mass (measuring 8 cm in diameter) showed uniformity with a low-echoic lesion (arrow).


Intraoperative findings. The mass was separated from the testis.


A surgical specimen of the intrascrotal mass resected with the skin.


Histologically, the cyst contained keratin flakes and its wall was covered with keratinizing squamous epithelium.


Neuroimaging findings of the patient. Head computed tomography performed on admission reveals a low-density area in the left frontal cortex (a).


Neuroimaging findings of the patient. Axial image from diffusion-weighted magnetic resonance imaging (MRI) reveals no abnormalities that indicate acute cerebral ischemia (b).


Neuroimaging findings of the patient. Fluid-attenuated inversion recovery (FLAIR) shows high-intensity lesions in the left frontal cortex and very thin subdural hematoma (arrows) (c).


Neuroimaging findings of the patient. Gadolinium-enhanced MRI shows leptomeningeal enhancement along the superior frontal gyrus, which is involved in focal cortical hyperintensity in the left frontal lobe of FLAIR imaging (d-f).


Neuroimaging findings of the patient. Gadolinium-enhanced MRI shows leptomeningeal enhancement along the superior frontal gyrus, which is involved in focal cortical hyperintensity in the left frontal lobe of FLAIR imaging (d-f). Note that dural thickening, pituitary swelling, and tonsil herniation are not observed (e and g).


Neuroimaging findings of the patient. Note that dural thickening, pituitary swelling, and tonsil herniation are not observed (e and g).


Neuroimaging findings of the patient. Magnetic resonance venography shows patency of the intracranial main venous system (h).


Intraoperative photographs of the patient. The fluid-attenuated inversion recovery high-intensity lesion is exposed through small craniotomy (a). Note that a tack-up suture is placed (arrows) since the dura mater separates away from the skull spontaneously (a and b), although the brain does not look sunken in the photographs because we lowered the patient's head position to increase the intracranial pressure.


Intraoperative photographs of the patient. Note that a tack-up suture is placed (arrows) since the dura mater separates away from the skull spontaneously (a and b), although the brain does not look sunken in the photographs because we lowered the patient's head position to increase the intracranial pressure.


Intraoperative photographs of the patient. Magnified intraoperative photo shows that the cortical vein is discolored (black).


Intraoperative photographs of the patient.indocyanine green video angiography shows the absence of flow that signifies thrombosis of the vein.


Panoramic X-ray: Diffuse limited borders in the region of the right mandible with bone sclerosis and narrowing of the mandibular canal.


(a-c) Computed tomography: Axial, coronal, and sagittal view: Diffuse limited borders with slight erosion of the right cortical mandible and reduction of trabecular bone microstructure. The mandibular canal was breached.


Magnetic resonance imaging: Axial view, T1: Enlarged, contrast-enhancing mass of the right mandible.


Positron emission tomography/computed tomography: Axial view: Uptake of 18F-fluorodesoxyglucose of the right mandible.


The CT topogram shows that the distal part of VP shunt is lying in the right-upper-quadrant superimposed on the hepatic silhouette.


(a) Abdominal CT scans with oral contrast demonstrates an intrahepatic fluid collection (asterisk) measuring 8.1 x 7.4 cm in the right hepatic lobe.


(b) The VP shunt catheter tip is seen inside the pseudocyst (arrow).


Preoperative.


Follow-up abdominal CT scan at 19 days after VP shunt removal. Axial abdominal CT scan shows the complete resolution of the hepatic CSF pseudocyst.


18F-fluorodeoxyglucose whole-body positron emission tomography-computed tomography scan maximum intensity projection (after potassium chloride infusion): Altered physiological distribution of 18F-fluorodeoxyglucose with markedly increased uptake in almost all major muscle groups, including those of the neck, thorax, abdomen, and pelvis.


18F-fluorodeoxyglucose whole-body positron emission tomography-computed tomography scan maximum intensity projection (12 h after stopping potassium chloride infusion): Normal biological distribution with minimal uptake in muscles.


Pretreatment intraoral photographs.


Normal intraoral appearance during the onset phase.


"Twin-Block" functional appliance used in the patient.


No relevant findings evident on orthopantomogram examination.


Bone marrow aspirate smear (from bone marrow biopsy) stained with May-Grunwald Giemsa showing amastigote forms of Leishmania spp.


Viral load and CD4+ T-cells count evolution following cART initiation and VL diagnosis. TRIP = travel in Greece; H = date of hospitalization; (c)ART = (combined) anti-retroviral therapy; BMB = bone marrow biopsy (VL diagnosis); M1 = first month after cART initiation; M3 = third month after cART initiation; M6 = sixth month after cART initiation; LAmB = intravenous liposomal amphotericin B administrations.


MRI of the patient showing the rt seminal vesicle sandwiched between bladder and rectum.


MRI showing the tumor's relationship to the ureter.


Intraoperative picture showing the tumor.


Enbloc removal of the rt seminal vesicle along with partial cystectomy.


The treatment procedures and corresponding leukocyte counts in the patient's cerebrospinal fluid. Monocytes were predominant among CSF white cells; they had a proportion of approximately between 60 and 90%. The CSF protein level was also elevated to 95.00-125.20 mg/dl. mNGS. P, metagenomic next-generation sequencing of cerebrospinal fluid detected Sarocladium strictum positive; Culture. P, Sarocladium strictum was positive in cerebrospinal fluid culture.


(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the bone window showing an osteolytic lesion with expansion and a periosteal reaction with the appearance of sunrays around the periphery (arrows).


(B) Sagittal reconstructed CT image of the sternum showing the lesion involving the manubrium and almost all the body of the sternum. The lesion is slightly expansile and the cortex is partially destroyed.


(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the soft tissue window showing that the bone marrow of the sternum has been substituted by homogeneous soft tissue.


(B) Axial contrast-enhanced CT image of the manubrium sterni showing marked homogeneous enhancement of the tumor.


(A) T1-weighted sagital image (repetition time/echo time, 590/21 msec) of the sternum showing an area of low signal intensity in the manubrium and body of the sternum.


(B) Short-tau inversion recovery T2-weighted sagittal image (repetition time/echo time, 4150/106 msec) of the sternum showing an area of high intensity in the same region; the soft-tissue mass is clearly demonstrated.


(A) Histopathological examination (hematoxylin and eosin stain; original magnification, x200) demonstrating proliferation of round cells with abundant cytoplasm and eccentric nuclei with coarse chromatin, indicating a plasmacytoma.


(B) Immunohistochemical analysis revealing positive cluster of differentiation 38 staining on the cell membrane (arrow), which is characteristic of a plasmacytoma (original magnification, x200).


Treatment timeline for CRKP infection.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. Histograms compared Chao1 index.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. Shannon index. Of the fecal microbiome in the donor and the patient pre- and post-FMT.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. PCoA plots showed the microbial community variation of the donor and the patient pre- and post-FMT based on weighted UniFrac distance.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. And unweighted UniFrac distance FMT 1W, FMT 3W and FMT 2M represented 1 week, 3 weeks and 2 months after FMT.


The clinical course of the patient (schematic). Hematoxylin and eosin staining of the liver specimen shows some punctate necrosis on the lobule, apoptotic bodies in the hepatic cord, fatty degeneration of hepatocytes, mild inflammation in the portal area, and eosinophil infiltration in the inflammatory necrosis area.


Timeline with relevant data from the episode of care; curves of body temperature and eosinophils count. The blue line shows the body temperature values. The orange line shows the eosinophil counts. Horizontal thick lines show the medications administered. PIP-SBT, Piperacillin-sulbactam.


Imaging features of the patient. (A) Abdominal MRI enhancement showed that the right lobe of the liver scattered flakes, irregular shape, enhanced uneven enhancement on hospital day 2.


Imaging features of the patient. (B) Abdominal CT enhancement showed liver multiple nodules, mass slightly low-density shadow, edge enhancement on hospital day 13.


Imaging features of the patient. (C) Abdominal CT enhancement showed multiple cystic and tubular low-density shadows scattered in the liver, and some showed edge enhancement on day 33.


Imaging features of the patient. (D) Abdominal CT enhancement showed multiple cystic and tubular low-density shadows scattered in the liver, some showed edge enhancement, and a few lesions were smaller than those before on follow-up day 69.


Imaging features of the patient. (E) Abdominal MRI enhancement showed cystic and tubular shadows in the right lobe of the liver, with irregular shapes and edge enhancement in the enhanced part. Some lesions were smaller than before on follow-up day 137.


Imaging features of the patient. (F) Abdominal MRI enhancement showed the right lobe of the liver scattered flakes, irregular shape, enhanced edge uneven enhancement, lesions significantly reduced on follow-up day 418.


Lesion with hypersignal on T2 in the regions of midbrain and right parahippocampus.


Hyperintense lesion on T2 at the midbrain peduncle, mimicking a mesencephalic tumor.


Microphotograph showing clusters of round-to-oval cells (MGG, x100). Inset showing wisps of magenta-colored material (MGG, x400).


Microphotograph showing spindle-shaped endothelial cells (arrow) crossing a cluster of tumor cells (MGG, x400).


Histopathologic sections showing nests and sheets of tumor cells around endothelium-lined small blood vessels (Hand E, x100).


A; Brownish macule with a bluish center on the dorsum of the right foot.


B; Dermoscopy showing a blue-steel pigmentation in one part and a violaceous color in the other, with hypopigmented areas.


C; Histology showing dermal proliferation of spindle cells organized in fascicles with a storiform pattern or in nests. H&E. Original magnification, x10.


D; Melan-A was diffusely positive. Immunohistochemistry. Original magnification, x5.


MRI of the neck with gadolineum. A) Sagittal T1 image illustrating an intramedullary enhancing mass from the cervicomedullary junction to C4. Leptomeningeal enhancement is also present.


MRI of the neck with gadolineum. B) Axial T1 image illustrating the intramedullary mass and leptomeningeal enhancement.


MRI of the neck with gadolineum. C) Axial image of cervical spine illustrating a dumbbell mass extending through C5-C6 neural foramen and paraspinal mass.


MRI of the neck with gadolineum. D) Coronal T1 image illustrating intramedullary mass.


HandE staining illustrating small round blue cells with high mitotic rate, atypical mitosis (red arrow), and pleomorphic nuclei (green bracket) characteristic of a primitive neuroectodermal tumor.


Immunohistomchemical staining. A) GFAP positive b) Synapthophysin positive, illustrating positivity around a binucleated cell (red arrow).


Preoperative radiograph of the patient.


Preoperative CT images demonstrated extensive vertebral body destruction, several facet joint dislocations and mild retrolisthesis of C4 to C5 segment.


Sagittal cervicothoracic MR images demonstrated pathologic contrast enhancement on C4 to T7 segments along with vertebral body involvement and spinal canal compression at the level of C4 to T4. From coronal MR images, a large paravertebral abscess was presented anteriorly.


Postoperative radiograph demonstrated pedicle rod and screw construct that resulted in improved kyphotic deformity.


Abdominal CT scan shows massive ascites.


Umbilical cord cyst images. . A: Umbilical cord cyst first detected at 20 0/7 weeks of gestation (arrow).


Umbilical cord cyst images. B: Umbilical cord cyst was confirmed and a clear image of the connection between the bladder and the umbilicus was found at 22 5/7 weeks of gestation.


Umbilical cord cyst images. C: Doppler velocimetry demonstrated flow around the cyst.


Umbilical cord cyst images. D: Doppler ultrasound examined the size of the cyst.


Fusiform mass in dorsal aspect of the index finger.


Histopathologic examination revealed proliferation of fibroblasts, dposit of osteoid, osteoblasts, and giant cells.


Photograph of a 9-year-old Japanese boy showing corneal infiltrate with surrounding edema in the right eye.


Twelve months after the initial visit, there is slight corneal opacity in the patient's right eye.


Echocardiography of the three presented cases. . Notes: Parasternal long-axis views . (A and B) Case 1: granular sparkling appearance was seen in the interventricular septum (IVS), which was 11.5 mm in thickness.


Echocardiography of the three presented cases. Apical four-chamber views . (A and B) Case 1: granular sparkling appearance was seen in the interventricular septum (IVS), which was 11.5 mm in thickness.


Echocardiography of the three presented cases. . Notes: Parasternal long-axis views . (C and D) Case 2: granular sparkling appearance was seen in the IVS and the lateral wall.


Echocardiography of the three presented cases. Apical four-chamber views . (C and D) Case 2: granular sparkling appearance was seen in the IVS and the lateral wall.


Echocardiography of the three presented cases. . The IVS of Case 2 was less thickened (9.8 mm in thickness), but the left ventricular wall exhibited diffuse hypertrophy with diastolic dysfunction (E/e' 15.55) without valvular dysfunction. (E and F) Case 3: granular sparkling appearance was shown in the IVS and lateral wall, and the IVS was 13.0 mm in thickness.


Echocardiography of the three presented cases. . Are presented. (E and F) Case 3: granular sparkling appearance was shown in the IVS and lateral wall, and the IVS was 13.0 mm in thickness.


The abdominal computerized tomography of Case 3. . Notes: The abdominal wall around the navel was ~3-5 mm in thickness, where FNAB-AFP is usually performed. The white arrow indicates where FNAB of the hip was performed. . Abbreviations: AFP, abdominal fat pad; FNAB, fine-needle aspiration biopsy.


Coronal.


Sagittal.


Axial images of chest computed tomography demonstrating a mass (arrow) invading the right pulmonary artery (PA).


(d) Image obtained during endobronchial ultrasound-guided transbronchial needle aspiration showing the sampling needle inside the intra-arterial mass (arrow) within the lumen of the pulmonary artery.


The fixed smears demonstrate loosely cohesive clusters of spindled cells with irregular elongated nuclei (Papanicolaou).


The air-dried smears show pleomorphic cells; many have large, irregular nuclei and finely vacuolated cytoplasm (Diff-Quik).


The gross resection shows the lumen of the pulmonary artery completely occulted by tumor.


(a) The resected tumor demonstrates spindled cells with a storiform pattern (H and E). (b). Higher magnification shows pleomorphic cells with convoluted to spindled nuclei, often containing nucleoli (H and E).


Surgical specimen. A; Macroscopic view.


Surgical specimen. B; Hematoxylin and eosin staining at 5-fold magnification revealing a fissure, transmural inflammation and architectural changes of the surrounding mucosa.


Surgical specimen. C; Hematoxylin and eosin staining at 100-fold magnification revealing non-caseating granulomas within a draining lymph node.


Magnetic resonance imaging of the lesion on the superior pole of the spleen.


Low power photomicrograph showing variable sized nodules (H&E 40x).


Renal biopsy - light microscopy. . Notes: Light microscopic examination of renal biopsy: (A) trichrome stain showing moderate tubular atrophy, interstitial fibrosis and interstitial inflammation (affecting 50% of cortical area). No interstitial granulomas are seen.


Renal biopsy - light microscopy. (B) Hematoxylin and eosin stain of glomeruli showing glomerular crescent.


Renal biopsy - light microscopy. (C) Trichrome stain of glomeruli showing necrotizing crescent. Out of 19 glomeruli examined, nine showed complete or near complete global sclerosis.


Renal biopsy - immunofluorescence microscopy. . Notes: Immunofluorescence microscopy of renal biopsy (A and B): Immunofluorescence (IF) staining shows weak linear staining of glomerular basement membranes for IgG. Area of non-staining in figure B represents crescent. The IF was also positive for kappa and lambda light chains (not shown). Segmental glomerular tuft staining for IgM, C3, and fibrinogen were also positive (not shown). The linear staining for IgG was not seen in the previous kidney biopsy and suggests the possibility of coexistent pauci-immune glomerulonephritis and anti-glomerular basement membrane nephritis.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (A) Hematoxylin and eosin (H&E) stain of glomeruli showing cellular crescent.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (B) H&E stain of another glomeruli showing cellular crescent.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (C) Trichrome staining of glomeruli showing necrosis (red).


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (D) Trichrome staining of another glomeruli, showing necrosis (red).


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (E) Trichrome staining showing moderate tubular atrophy and interstitial fibrosis. Immunofluorescence staining was negative (not shown). Electron microscopy revealed 30% foot process effacement but no immune type electron dense deposits or endothelial tubuloreticular inclusions (not shown).


(A) Examples of SEMP recorded from proximal (RF) and distal (TA) muscles during stimulation at Th9-10, Th10-11, Th11-12, Th12-L1, and L1-2 levels, in supine position.


(B) Changes in the thresholds, maximal amplitudes, and the latency of the SEMP recorded from proximal (RF and MH) and distal (TA, SOL) muscles with stimulation applied at Th9-10, Th10-11, Th11-12, Th12-L1, and L1-2 levels.


(C) Examples of the SEMP recorded from RF, MH, TA, and SOL with paired pulses stimulation (interstim interval of 50 ms) at Th11-12 level. Black arrow indicate the moment of the stim.


(D) The amplitudes of the SEMP recorded from right and left side during paired stimulation at Th11-12 level.


Examples of M wave.


(F) The amplitudes (%) of the H-reflex recorded from right and left side (n = 10) during performance of Jendrassik maneuver (gray bars). Dotted lines indicate the control values of the H-reflex (100.


(G) Examples of the SEMP recorded from RF and TA during stimulation at Th12-L1 without (black line) and with Jendrassik maneuver (gray line) in supine and in upright (less than 30% body weight support) positions. Gray circles indicate the facilitation of the SEMP bilaterally RF, and in left TA by Jendrassik maneuver.


Reflex recorded form SOL muscle at stimulation intensity varied from 8 to 25 mA with increment of 1 mA. Recruitment curves of the M wave (black line) and the H-reflex (light gray line) presented on the right. (H) The amplitudes (%) of the SEMP recorded from right and left proximal (RF and MH) and distal muscles (TA and SOL) with stimulation at Th12-L1 during performance of Jendrassik maneuver in supine (light gray) and upright (less than 30% body weight support) positions (dark gray) in subject with SCI (n = 4). Dotted lines indicate the control values of the SEMP (100%). Difference marked with an asterisk indicates significance (*p < 0.05).


(A) Examples of the SEMP recorded from TA muscle during stimulation at Th11-12 level in supine and upright (less than 30% body weight support) positions after the first verticalization before (gray lines) and after rehabilitation therapy (black lines).


(B) The thresholds of the SEMP recorded in supine (gray lines) and upright (less than 30% body weight support) position after the first verticalization (black lines) in TA, SOL, RF, and MH (n = 6).


(C) Changes in amplitude and threshold of SEMP recorded from RF, MH, TA, and SOL in supine position before (gray) and after (black) rehabilitation therapy (n = 4).


(D) Example of the SEMP recorded from TA during stimulation at Th11-12 level in upright position (less than 30% body weight support) before (gray line) and after rehabilitation therapy (black line). The black and gray numbers indicate the number of polysynaptic components of the SEMP. Histograms and cumulative percentage of latencies (ms) of polysynaptic components of the SEMP recorded from TA before and after rehabilitation. Counts - frequency of occurrence of latencies of LR in interval of 1 ms. Cumulative percent - cumulative percentage of frequency of occurrence of latencies of LR in interval of 1 ms. Difference marked with an asterisk indicates significance (*p < 0.05).


Positron emission tomography-magnetic resonance imaging fusion with T1 radial volumetric interpolated breath-hold examination with fat suppression acquired in the axial plane showed severely decreased radiotracer activity throughout the liver parenchyma (white arrow) (a).


Corresponding axial T1 radial volumetric interpolated breath-hold examination with fat suppression image (b) revealed generalized decreased magnetic resonance signal in the liver.


Axial positron emission tomography attenuation corrected image.


Showed severe decreased liver uptake (black arrow) which was not present on the nonattenuation corrected images.


Dixon three-dimensional volumetric interpolated breath-hold examination T1-weighted magnetic resonance sequence in the coronal plane demonstrates normal signal intensity in the liver parenchyma (arrow) on the out-of-phase image.


With drop in signal on the in-phase image indicating excessive iron accumulation.


The mu map showed the expanded boundary of the right lung instead of the correctly assigned soft-tissue density of the liver parenchyma (curved arrow) (c).


The coronal attenuation mu map was manually segmented by filling in the faulty liver reconstruction (thin arrow) with soft-tissue density instead of lung tissue (a). The resulting attenuation corrected positron emission tomography image in the coronal plane showed the properly corrected liver parenchyma tracer activity (thin arrow).


Unrelated to the liver, multiple osseous metastases are noted on the study (arrowheads) (b).


Fluorodeoxyglucose positron emission tomography-magnetic resonance imaging scan after oral chelator therapy with attenuation corrected positron emission tomography axial image demonstrating normal fluorodeoxyglucose uptake within the liver (a).


Corresponding T1 radial volumetric interpolated breath-hold examination with fat suppression image showed improved liver signal intensity reflecting decreased iron deposition (b).


Flexible endonasal fiberscopic findings of the left nasal cavity. Hypertrophy of the left inferior turbinate was present, and the left inferior nasal meatus had disappeared (white arrowheads).


A; Large pseudotumoral neoangiogenic lesion of the left perioral area.


B; Magnification of the pseudotumoral neoangiogenic process.


C; Complete crusting after 2 weeks of antiviral therapy.


D; Residual erythematous post-inflammatory pigmentation at 4 weeks.


A; Histology evidencing PG (HE. X10). The black arrow indicates epithelial cell islands in the PG. B, c High-power magnification illustrates some keratinocytes exhibiting CPE. D HSV-I-specific immunostaining (red signal) in giant epithelial cells (black arrows), some exhibiting cytopathic signs (x20).


Fluorescein angiographic images of the right.


Left. Eyes. . Note: Many arch-shaped hyperfluorescent linear lesions running circumferentially are observed in the peripheral fundus of both eyes (arrowheads), and part of these lesions can be seen to run in parallel.


Fundus autofluorescence of the right.


Left. Eyes. . Note: Linear hypoautofluorescent lesions are observed at sites corresponding to the hyperfluorescence in the FA images (arrowheads). . Abbreviation: FA, fluorescein angiographic.


Abdominal computed tomography revealing a right renal enhancing mass about 5 cm in length, accompanied by the parenchyma invasion and pelvis expansion of the right kidney. . Notes:. Cross section.


Abdominal computed tomography revealing a right renal enhancing mass about 5 cm in length, accompanied by the parenchyma invasion and pelvis expansion of the right kidney. Coronal plane.


(A and B) Removing the entire right kidney under robot-assisted laparoscopic nephrectomy.


Pathological features of the surgical specimen. . Notes: (A and B) Microscopic view of the tumor of the right kidney with H&E staining, revealing that tumors were composed of a monotonous population of small round cells. Magnification details:. 40x.


Pathological features of the surgical specimen. . Notes: (A and B) Microscopic view of the tumor of the right kidney with H&E staining, revealing that tumors were composed of a monotonous population of small round cells. 200x.


Pathological features of the surgical specimen. Immunohistochemical staining was positive for. CD99,. 100x.


Pathological features of the surgical specimen. SYN,. 100x.


Pathological features of the surgical specimen. FLI1, and . 200x.


Pathological features of the surgical specimen. Ki67. 100x.


Fluorescence in situ hybridization testing demonstrated that more than 10% of cells were positive indicating EWSR1 gene rearrangement.


Medical image.


68Gallium-prostate-specific membrane antigen positron emission tomography image fused with the corresponding T2-weighted magnetic resonance imaging. Showing focal tracer uptake (red arrow) on the side opposite to the magnetic resonance imaging-detected hypointense lesion (yellow arrow). While no obvious magnetic resonance imaging lesion is seen corresponding to the prostate-specific membrane antigen uptake.


T2-weighted magnetic resonance imaging of prostate showing a hypointense nodule involving the left anterior and posterior transitional zone at the base with low ADC values.


(e) Hematoxylin and eosin-stained specimen of radical prostatectomy showing the acinar adenocarcinoma (from both right and left lobe transition zones).


(a) Chest X-ray showing well-defined homogenous opacity in the left hemithorax (white arrow).


(b) Computed tomography chest showing cystic lesion in the middle and posterior mediastinum (white arrow).


(a) Peroperative finding showing cystic structure below the left lung.


(b) Histopathological examination of the cyst showing columnar lining with mild inflammation. Muscularis mucosa, subcutaneous layer, and muscularis propria can be appreciated confirming the diagnosis of enterogenous cyst.


Characterization of sSMC using chromosome 18 centromere (red) and short arm subtelomeric region (green) fluorescent probes. The result demonstrated that the sSMC is a derivative of chromosome 18.


The physical examination was notable for necrotic-appearing tissue in the entire penis and scrotum, with areas of induration and crepitus.


MRI of the upper arm showing a spindle shaped contrast enhancing mass in the median nerve course.


MRI of the upper arm showing a spindle shaped contrast enhancing mass in the median nerve course. Coronar view. Axial view.


A-B) Preoperative MRI. T1-weighted sagittal and T2-weighted axial images demonstrating the tumour mass with a cystic component and extension into the floor of the fourth ventricle and to the supravermian cistern. Partial obstruction of the fourth ventricle and secondary obstructive hydrocephalus is also observed.


C-D) Two-year postoperative MRI. No apparent residual tumour is shown at T1-weighted sagittal and T2-weighted axial images.


Microscopic features of the rosette-forming glioneuronal tumour. A) Histological features of the tumour showing both a neurocytic and an astrocytic component. Neurocytic rosettes are formed by the neurocytic components.


Microscopic features of the rosette-forming glioneuronal tumour. B) The eosinophilic core at the centre of the neurocytic rosettes displays strong positive staining with synaptophysin.


Microscopic features of the rosette-forming glioneuronal tumour. C) The astrocytic components of the tumour showed that the tumour cells had bipolar and spindle processes with positive immunostaining of GFAP.


Microscopic features of the rosette-forming glioneuronal tumour. D) The MIB-1 labelling index was about 5-7%. Original magnifications 400x.


A-B) MRI scans 48 months after the initial procedure. T1-weighted sagittal and T1-weighted axial contrast enhanced images reveal a nodular lesion close to the roof of the fourth ventricle.


C-D) T1-weighted sagittal and T2-weighted axial MRI images two years after radiosurgery show stabilisation of the lesions.


Treatment planning for gamma knife radiosurgery. A) Sagittal view.


Treatment planning for gamma knife radiosurgery. B) Axial view.


Treatment planning for gamma knife radiosurgery. C) Coronal view.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Lung windows from computed tomography of the abdomen and pelvis demonstrate nodules in the left (red arrow) and right (yellow arrow) lower lobes.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Follow-up computed tomography chest on lung window demonstrates stability of one of the larger nodules in the left lower lobe (red arrow). Additional nodules (yellow arrows) are seen at slightly different levels than on prior study due to differences in positioning and level of inspiration.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Fused images from F-18 fluorodeoxyglucose positron emission tomography- computed tomography demonstrate the index lesion without abnormally increased glucose metabolism.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma (PHG) associated with idiopathic thrombocytopenic purpura. A) x10 magnified H and E, stained microscopy of the two nodules from wedge resection (long arrows) shows clusters of lymphoplasmacytic infiltrate (short arrows) peripherally. B) x20 magnified view demonstrates whirled layers of collagen (dark pink) around small blood vessels (*), consistent with PHG. No multinucleated giant cells are present.


(A-D) Abdominal CT revealed a soft tissue nodule measuring 1.3x1.5 cm in the subcutaneous soft tissue of the right abdominal wall and a cystic density mass measuring 9.9x8.7 cm in the peritoneal cavity.


Abdominal CT scans before and after anlotinib therapy. . Notes: (A) Before anlotinib therapy, the CT scan shows the size of the enlarged right inguinal lymph node was 29.3x19.8 mm.


Abdominal CT scans before and after anlotinib therapy. (B) Before anlotinib therapy, the CT scan shows the size of the omental lymph node was 17.8x14.9 mm.


Abdominal CT scans before and after anlotinib therapy. (C) After two cycles of anlotinib treatment, the CT scan shows the size of the enlarged right inguinal lymph node was 12.2x10.7 mm.


Abdominal CT scans before and after anlotinib therapy. (D) After two cycles of anlotinib treatment, the CT scan showed the size of the omental lymph node was 9.9x7.9 mm, respectively.


Gross image of the uterus and tumor.


Mixed components: a close transition from the endometrial adenocarcinoma to the yolk sac tumor areas (hematoxylin and eosin, 100x).


Immunohistochemical staining results for alfa-fetoprotein confirm the existence of two components of endometrial adenocarcinoma and yolk sac tumor.


Axial.


Coronal. T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesion with parenchymal invasion along the right frontal lobe (arrow).


Axial ,. Along the falx cerebri.


Coronal. Right temporal lobe.


Sagittal. T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesions through the frontal sinus, and . Right sphenoid wing. (arrows).


Sagittal. T1-weighted magnetic resonance imaging showing a contrast-enhancing sinonasal mass with intracranial extension through the cribriform plate into the anterior cranial fossa, maxillary, and sphenoid sinuses.


Sagittal T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesions posterior to C2 vertebral body.


Posterior to T9-T10 disc space.


Along the posterolateral dura at the L3-L4 level. (arrows).


A 4-month-old female with emesis. Coronal T2 3D magnetic resonance cholangiopancreatography shows the pancreas divisum with the main pancreatic duct draining into the duct of Santorini (arrow). The common bile duct drains into a complex conglomeration of pancreatic head cysts (asterisk). The common bile duct is mildly prominent, and there is ascites.


Same patient as above. Coronal T2 3D magnetic resonance cholangiopancreatography shows the 1.9 cm common cyst (arrow) that drains the duct of Santorini and the common bile duct. There are multiple cysts and ducts that extend throughout the pancreatic head with multiple connections to the duodenum (asterisk).


Same patient as above. Axial T2 fat-saturated image shows a large pancreatic pseudocyst (asterisk), with layering debris, exerting mass effect on the pancreatic head. There is ascites.


Axial view of a CT with contrast of neck showing peripherally enhancing fluid collection at the left submandibular space along with extensive gas collection extending from the left submandibular to the left parapharyngeal space.


CT scan with oral and rectal contrast (R) showing a pelvic mass with multiple heterogeneously enhancing soft tissue masses with central necrotic areas within pelvis not separately seen from the ovaries (EST).


Sagittal section showing heterogeneously enhancing soft tissue lesions within omentum (OM), M- pelvic mass seen indenting bladder base ,. Bowel. Loops are displaced upwards.


Intraoperative omental nodular metastatic deposits (OD).


Metastatic deposits (D) on the descending colon (DC).


H&E x 20: biphasic neoplasm showing both benign epithelial component and sarcomatous mesenchymal component.


Immunostain CK7x20:epithelium is positive for CK7 (brown).


Immunostain, CD10x- Mesenchymal component is positivity for CD-10 (brown).


Thyroid tuberculosis in a 45-year-old patient. (A) Sonogram image revealing an ovoid-shaped, heterogeneous, hypoechoic nodule with ill-defined margins in the left thyroid lobe, resembling a cystic nodule with fluid space (white arrow).


Thyroid tuberculosis in a 45-year-old patient. (B) Color Doppler examination revealing punctated and banded flow signals around the nodule.


Repeat ultrasound examination at three days post-admission. (A) Longitudinal sonograms revealing a nodule, closely adjacent to the left salivary gland and partially protruding from the upper pole of capsular tissue into the left lobe of the thyroid.


Repeat ultrasound examination at three days post-admission. (B) A blood flow signal can be observed around the nodule.


Repeat ultrasound examination at three days post-admission. (C) Fine-needle aspiration cytology of the nodule.


Repeat ultrasound examination at three days post-admission. (D) The aspiration yielded reddish pus that was revealed to be red blood cells with necrosed materials.


Repeat ultrasound examination at three days post-admission. (E) Follicular epithelial cells on a bloody background, with clusters of purple-stained colloid and a field of red-stained granular caseous necrosis.


Repeat ultrasound examination at three days post-admission. (F) Multifocal granulomatous nodules inbetween atrophic thyroid follicules, with fibrous tissue proliferation and chronic inflammatory cell infiltration. (E anf F: stain, hematoxylin and eosin; magnification, x200).


Repeat ultrasound examination six months after the initiation of anti-tuberculosis medication. (A) Significant shrinkage and echo enhancements can be observed. The nodule is solid and well-defined, with two tiny calcifications inside (white arrows).


Repeat ultrasound examination six months after the initiation of anti-tuberculosis medication. (B) Color Doppler examination revealing punctate and strip-shaped blood flow around and inside the nodule.


Contrast-enhanced computed tomography scan of the abdomen showing a diffuse circumferential thickening of the distal pyloric antrum of the stomach with a few ulcerative areas.


A; On magnetic resonance imaging, an heterogeneous multinodular mass was observed on sagittal T1-weighted images (TR/TE: 1,200/120). Dark signal nodules, compatible with hemosiderin deposition, were identified.


B; On macroscopy a multinodular lesion was evident in the leg and in the thigh showing variegated colour.


C, d On haematoxylin and eosin staining the lesion showed synovial-like mononuclear cells without cytologic atypia, admixed with multinucleate giant cells.


Preopertaive axial view of current case showing. T1 (without contrast).


T1 (with contrast).


T2 (without contrast).


Immunohistochemically, the cells were positive for CD99. The complete reactivity pattern of the specimen is shown in Table 2.


The patient showing left eye proptosis with inferior displacement of the globe.


(a) MRI, coronal view of a heterogeneous intermediate signal (white arrow) of the left superior orbital mass, infiltrating the superior rectus muscle.


(b) The transverse view of the same heterogeneous mass (black arrow) displacing the globe anteriorly (proptosis).


Mature adipocytes (black arrow) intermingled with zones of atypical stromal cells (white arrow) (200x, H & E stain).


A; Hematoxylin and eosin, x10. Skin punch biopsy from right leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis.


B; Hematoxylin and eosin, x40. Skin punch biopsy from the right leg exhibits almost confluent parakeratosis and an absent granular layer with Munro's microabscesses. Some dilated papillary dermal vessels are noted.


C; Hematoxylin and eosin, x20. Skin punch biopsy from left leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis. Absent granular layer is evident, with denuded foci. Also seen is a hair follicle with parakeratotic plugging.


D; Hematoxylin and eosin, x40. Skin punch biopsy from left leg exhibiting almost confluent parakeratosis and an absent granular layer with Munro's microabscesses.


A; Improvement of both legs after 52 weeks of treatment with etanercept.


B; Improvement of both elbows after 52 weeks of treatment with etanercept.


Yellowish brown plaques and nodules around the eye.


Epitheloid histiocytic granulomas in the dermis with Touton and foreign body giant cells. The inset picture shows foci of the degenerated collagen with Touton giant cells.


Intra-operative photograph showing the released full thickness flap over the cheek.


Color Doppler ultrasound imaging. a on November 3, 2017 (23 + 4 weeks of gestation), color Doppler ultrasound imaging showed a hyperechogenic mass in the fetal left ventricle, measuring 1.8 cm x 1.57 cm, broadening of the left lateral ventricle (1.11 cm) and a strong dot-like echo in the left ventricle; b on December 7, 2017, color Doppler ultrasound reexaminations displayed multiple strong echoes in the fetal left ventricle (measuring 3.3 cm x 2.03 cm), compression of the left ventricular outflow tract, obvious enlargement of the tumor, and a 0.92 cm internal diameter of posterior horn of the left lateral ventricle.


Chromosomal microarray analysis detects a 1.8 Mb-duplication of the chromosome 15q13.2q13.3 region containing 7 genes, which occurs in the region between BP4-BP5 on chromosome 15q13.3.


Clinical response to long-term immunotherapy and the effect of surgery. (A) Schematics showing the time line of patient's diagnosis, treatment and response.


Clinical response to long-term immunotherapy and the effect of surgery. (B) Computed tomography scans and Magnetic resonance imaging showing clinical response to immunotherapy and the effect of surgery.


Clinical response to long-term immunotherapy and the effect of surgery. (C) The result of PD-L1 staining before immunotherapy.


Clinical response to long-term immunotherapy and the effect of surgery. (D) PET-CT scan before Lung tumor resection. TC, paclitaxel+carboplatin; Pembro, pembrolizumab.


Neck lymph node (LN) shows metastatic extremely well differentiated papillary thyroid carcinoma (EWD-PTC) E stain, x12.5.


Inset x400) with focal positivity of CK19. X400) in the first metastatic lesion.


The left thyroid shows follicular variant papillary thyroid carcinoma (FVPTC) without capsular (arrow) invasion E stain, x40.


Loss of CD56. X40) in second episode.


The LN also shows metastatic EWD-PTC E stain, x12.5.


Inset x400) with focal positivity of CK19. X400).


Neck lymph node (LN) shows metastatic extremely well differentiated papillary thyroid carcinoma (EWD-PTC) E stain, x12.5, and . The left thyroid shows follicular variant papillary thyroid carcinoma (FVPTC) without capsular (arrow) invasion E stain, x40, and . The LN also shows metastatic EWD-PTC E stain, x12.5, and . CD56. X400) in the second metastatic lesion. The skull lesion shows metastatic FVPTC E stain, x100.


The skull lesion shows metastatic FVPTC E stain, x100.


CD56. X400).