Show generalized diffuse scleritis with scleral abscess inferotemporal area.


A scleral tissue biopsy showing mucosal erosion and submucosal fibrosis with necrobiosis of collagen and sheets of mononucleated foamy histiocytes (xanthoma cells), infiltrating the submucosal fibrous tissue, accompanied by variable numbers of dispersed lymphocytes and plasma cells (hematoxylin-eosin; original magnification: x40).


Another scleral tissue biopsy predominantly containing fibrosis with necrobiosis of collagen and scattered necrotic cellular debris of inflammatory cells (hematoxylin-eosin; original magnification: x200).


Sheets of xanthoma cells and scattered hemosiderin- laden macrophages, neutrophils, lymphocytes, plasma cells, and erythrocytes. The xanthoma cells have small, round nuclei and abundant clear or vacuolated cytoplasm (hematoxylin-eosin; original magnification: x400).


Some of infiltrating histiocytes show hemophagocytic activity characterized by intracytoplasmic nuclear debris (hematoxylin-eosin; original magnification: x400).


Small- and medium-sized vasculitis characterized by lymphocytic and neutrophilic infiltrate in wall of subcutaneous vessels obtained from sural nerve biopsy (hematoxylin-eosin; original magnification: x200).


Axial view of the patient's computed tomography sca. Contrast-enhanced computed tomography.


Axial view of the patient's computed tomography sca. Bone window.


Intraoperative findings of the lesion. The tumor was noted to have a well-demarcated fibrous outer capsule, with erosion of the pericranium, and ,tight dura adherence.


Intraoperative findings of the lesion. The lesion received its main blood supply from the engorged middle meningeal artery.


Intraoperative findings of the lesion. Superior view of the lesion.


Intraoperative findings of the lesion. Inferior view of the lesion.


Anteroposterior radiograph of index finger showing soft tissue swelling but no bony involvement.


Gross histological specimen measuring 2.1cm x 1.5 cm x 1.5 cm.


Abundant giant cells, foamy macrophages, and spindle cells in the background of collagen bundle.


Sheets of mononuclear cells mixed with foamy macrophages and focal presence of osteoclastic type multinucleate cells evenly distributed in the fibrotic stroma.


Fournier's gangrene involving the anterior scrotum before debridement.


Integra placement over the scrotal defect.


The incorporated Integra following removal of the outer silicone sheet at the time of split-thickness skin-graft placement, 2 weeks following initial Integra placement.


Well-healed skin graft, 1 week following skin-graft placement.


Well-healed skin graft, 3 weeks following skin-graft placement.


CT scan of a patient with an SPT. Abdominal contrast-enhanced CT scan shows an enlarged pancreatic head containing a well-defined, encapsulated solid cystic mass about 4 cm in diameter (arrow). CT, computed tomography; SPT, solid pseudopapillary tumor.


Gross examination of an SPT. Photograph of the.


Gross examination of an SPT. Gross specimen shows the. Smoothly encapsulated tumor with areas of necrosis and hemorrhage. The ruler shows distance in centimeters.


The immunohistochemical features of an SPT. The tumor cells showed positive for. Vimentin.


The immunohistochemical features of an SPT. CD10.


The immunohistochemical features of an SPT. Alpha-antichymotrypsin.


The immunohistochemical features of an SPT. Alpha-antitrypsin.


The immunohistochemical features of an SPT. Beta-catenin.


The immunohistochemical features of an SPT. Neuron-specific enolase.


The immunohistochemical features of an SPT. Synaptophysin.


The immunohistochemical features of an SPT. Progesterone receptor.


A gray-scale ultrasound image shows a well-defined circumscribed ovoid heteroechogenic placental mass with a 4.99 cm diameter. . Note: The mass protrudes from the fetal surface of the placenta and is in contact with the amniotic cavity.


A gray-scale ultrasound image shows the protruding placental mass into the amniotic cavity from a placenta with the thickest anteroposterior diameter of 5.5 cm.


Macroscopic appearance of the placenta after normal vaginal delivery. . Note: A 5-cm-diameter mass on the fetal surface of the placenta near its edge is shown.


The atypical marginal location of the placental chorioangioma near the placental edge.


(a) The clinical image irregular asymmetric lump in the medial aspect of the left nipple-areolar complex.


(b) Ultrasonography image: Heterogeneous lesion with multiple hypoechoic areas and internal moving echoes was noted.


(c) Giemsa stain (x200): Smears show polymorphs and mature squamous cells.


(d) Pap stain (x200): Smear shows a multinucleated foreign body type of giant cell.


Plain and contrast-enhanced computerized tomography showing the hilar Bosniak type 4 cyst with enhancing soft-tissue component (arrow).


Intraoperative picture showing the grayish tumor closely adherent to renal vessels.


Tumor cells staining negatively for Hale's colloidal iron stain (x40).


Axial CT image of the pelvis demonstrates a large fat containing mass within the presacral region (arrowheads). Fat within the mass is dark on the CT images (arrow).


Axial nonfat saturated . Bright fat on nonfat saturated image.


Fat saturated. T2-weighted MRI images of the pelvis also demonstrates a large fat containing mass within the presacral region (arrowheads). Saturates out on the fat saturated image. (arrows).


Clinical photograph showing diffuse scrotal swelling.


A; Axial CT image of the chest showing pneumomediastinum along with subcutaneous emphysema involving the chest wall on the left side.


B; Axial CT of the abdomen showing pneumoretroperitoneum surrounding the right kidney along with subcutaneous emphysema.


Optical coherence tomography angiography (OCTA) with the right eye represented by the right column.


The left eye by the left column The structural slabs a, b of the lesions in both eyes were obtained using an RPE-RPE fit segmentation.


Optical coherence tomography angiography (OCTA) with the right eye represented by the right column En face OCTA with customized segmentation between RPE and Bruch's membrane shows a type 1 neovascular network with evident aneurysmal dilatation, as demarcated by the crossing blue and green lines (c, d). Dense B-scan with angiographic flow overlay e, f demonstrates the corresponding cross-sectional view and the customized segmentation of the respective lesions.


The left eye by the left column The structural slabs a, b of the lesions in both eyes were obtained using an RPE-RPE fit segmentation. En face OCTA with customized segmentation between RPE and Bruch's membrane shows a type 1 neovascular network with evident aneurysmal dilatation, as demarcated by the crossing blue and green lines (c, d). Dense B-scan with angiographic flow overlay e, f demonstrates the corresponding cross-sectional view and the customized segmentation of the respective lesions.


Chest radiography revealed consolidation in the right lower lung field at the initial visit.


Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


Reddish and ulcerated lesion in the left great toe.


Histopathological findings. (a) Low-magnification view showing the architecture with ulcerated epidermis.


Histopathological findings. (b) High-magnification view showing myofibroblastic and fibrovascular proliferations, with mature woven bone rimmed by osteoblasts. No evidence of abnormal mitotic activity or cellular atypia was observed.


Follow-up image showing no recurrence of the mass after 6 months.


Preoperative photograph of the patient, taken anteriorly.


T1 weighted contrast bilateral breast MRI demonstrating a soft tissue intensity mass-like area attached to the right breast capsule with internal enhancing foci and trace periprosthetic fluid, in addition to enhancing foci at the deep margin of the left breast capsule.


Intraoperative photograph of bilateral explanted, textured, silicone breast prostheses and right breast capsule. There is evidence of bilateral rupture with hematoma within the implants.


Immunohistochemistry for CD68, a histocyte marker, highlights numerous foam histocytes within the lesion on the external surface of the right capsule.


This image shows vacuolated histiocytes and a foreign body-type giant cell, features of the silicone granuloma taken from the lesion on the external surface of the right capsule.


Intact insular aggregates of small cells amidst fibrovascular stroma (Pap, x100) with (inset) an intact insula enveloped by a single layer of endothelial cells (Pap, x400).


Cellular smears containing pleomorphic cells having very large nuclei (monster cells) with scanty cytoplasm. Few of the nuclei revealing nucleoli (Giemsa, x400).


Lesional cells revealed positive staining for vimentin (IHC, x200).


Renal biopsy specimen from the patient with serum creatinine of 1.98 mg/dL. A proximal tubule with denuded epithelium, exfoliating brush borders (black arrows) and mitotic figure (white arrow) is shown (x 400).


Preoperative view.


Suture placement (Intraoperative).


Post suture placement.


Postoperative day 100.


CT from March 1, 2018 shows extensive ascites with small bowel clumped from mesenteric retraction by cancer.


Case 1. Pre-chemotherapy imaging findings. The tumor was 2 cm in size.


Case 1. Pre-chemotherapy imaging findings. And had a maximum standardized uptake value (SUVmax) of 5.1 in positron emission tomography findings.


Preoperative magnetic resonance imaging views of the patient (a) Sagittal T1-weighted cerebral magnetic resonance imaging showing a third ventricular colloid cyst and significant hydrocephalus with ballooning of the corpus callosum.


(b) Axial T1 view of the same patient.


Gammknife plan summary showing axial, coronal and sagittal T1 weighted with contrast MRI views. 13 Gy at 65% was prescribed.


43 months Postoperative and Postradiosurgical Gammaknife treatment MRI views (a) Sagital T1 weighted cerebral MRI showing that the third ventricular colloid cyst has remained essentially the same with complete resolution of the hydrocephalus. Corpus callosum with normal thickness.


(b) Axial T1 views of the same patient.


Clinical photographs of the patient with 1p36 triplication. (A) Front view of the face.


Clinical photographs of the patient with 1p36 triplication. (B) Lateral view of the face. The major facial phenotype included strabismus, hypertelorism, low hairline, ear malformations, broad nasal bridge, wide mouth, thick lips and prominent incisors.


Fundus appearance of the right eye showing multifocal retinal opacities and superficial retinal hemorrhages involving the posterior pole. There is an associated optic disc swelling and mild vitritis.


Photomicrographs showing multinucleated giant cells shown by arrow, large number of elongated cells lying singly and clusters (Giemsa, x400).


Timeline for blood pressure and BMI of the patient. (A) The blood pressure and BMI of the patient during the follow-up are showcased as a timeline.


Timeline for blood pressure and BMI of the patient. (B) The blood pressure of the patient indicated as the mean arterial pressure had been maintained normal without anti-hypertensive drug treatment postoperatively.


Timeline for blood pressure and BMI of the patient. (C) BMI of the patient decreased lower than preoperative level 2 weeks postoperatively and then recovered 3 months after the operation.


T2 FLAIR image showing bilateral medial temporal hyperintensity. FLAIR = Fluid-attenuated inversion recovery.


FA of the patient's right eye taken over a 2-year period. . Notes: (A and B) Initial visit (early phase of FA of the right eye reveals a small irregular hyperfluorescence area inferonasal to the fovea with late-phase leakage that corresponds to the juxtamacular CNV lesion; arrows).


FA of the patient's right eye taken over a 2-year period. (C and D) One week after cessation of steroid therapy (a fulminant recurrence and development of CNV membrane with involvement of the fovea; arrows).


FA of the patient's right eye taken over a 2-year period. (E and F) Three months after PDT (progressive enlargement of CNV membrane).


FA of the patient's right eye taken over a 2-year period. (G) Recurrent activity of CNV membrane 8 months after the second intravitreal ranibizumab injection (circle).


FA of the patient's right eye taken over a 2-year period. (H) Two months after periocular triamcinolone injection combined with intravitreal ranibizumab injection (almost complete regression of active CNV membrane). . Abbreviations: CNV, choroidal neovascular membrane; FA, fluorescein angiography; PDT, photodynamic therapy.


Metastases of ductal carcinoma breast (WD) (fine-needle aspiration cytology) malignant cells in ductal configuration, (Pap stain, x40).


Metastases of ductal carcinoma breast (WD) (fine-needle aspiration cytology) malignant ductal cells in sheets with cellular discohesion and attempted internal ducts, (Pap stain, x40).


Metastases of melanocarcinoma (fine-needle aspiration cytology) dissociated round to polygonal melanocytes showing prominent nucleoli, binucleation and cytoplasmic fine melanin pigments, background shows melanin containing macrophages (Giemsa stain, x40).


Metastases of small cell carcinoma lung (fine-needle aspiration cytology) nested population of small to intermediate size cell with high N: C, nuclei show pepper salt chromatin and significant nuclear fragility (Giemsa stain, x40).


Metastases of clear cell renal cell carcinoma (fine-needle aspiration cytology) Sheet and tubular structures of cuboidal epithelial cells with low-grade malignant nuclei and cytoplasmic fine vacuoles, (Pap stain, x40).


T2 weighted MRI showing an expansile lesion involving C2 vertebra with cord compression.