Sagittal CT scan image showing a mesenteric amorphous aggregate surrounding the portal vein (arrows). The contrast media is visualized in the perianal area (arrow head) without appropriate visualization of the lymphatic system.


Transverse CT scan image showing a contact (star) between the caudal extremity of the right lobe of the pancreas (arrow) and the mesenteric aggregate (arrow head).


Hematoxylin and eosin staining. Pancreatic carcinoma displaying a sheet of large polygonal neoplastic cells with moderate anisokaryosis and a low mitotic index (star) with residual pancreatic acini (arrow head).


Hematoxylin and eosin staining. Mesenteric fat showing necrotic area (star) surrounded by vacuolated macrophages (arrow head).


(A)
Chlamydia psittaci detection in bronchoalveolar lavage fluid (BALF) using metagenomic next-generation sequencing (mNGS) on October 25, 2020.


Positron emission tomography-computed tomography chest image demonstrates a localized mass in right posterior mediastinal/ paraspinal region with maximum standardized uptake value of 6.6.


Field's stained smear shows cohesive group of cells on a myxoid background (MGG, x2.5). This smear pattern correlates with groups of tumor cells surrounded by fibrous septa on histology. High power view of vacuolated cells somewhat resembling physalipherous cells, but differentiated from them by pleomorphic large nuclei and prominent nucleoli (inset).


Loosely cohesive epithelioid cells with eccentric nuclei, prominent nucleoli, and ample cytoplasm resembling adenocarcinoma. Note the cell showing vacuolated cytoplasm with magenta droplet (arrow) (myxoid background, x63). Mucicarmine stains were negative to faintly positive.


Clusters of epithelioid cells with abundant, poorly defined cytoplasm, mildly pleomorphic nuclei with irregular nuclear membranes (grooves and notches), prominent eosinophilic nucleoli, and chromatin condensation. Rare signet-ring like cells are seen. The myxoid stroma is less obvious in the Papanicolaou (Pap)-stained smear (Pap, x63).


Immunohistochemical results. Tumor cells are positive for calretinin, WT-1, and D2-40, and negative for high molecular weight keratin and thyroid transcription factor-1 supporting mesothelial origin. Mucicarmine stain is negative excluding adenocarcinoma.


Dorsal plane whole-body CT, fused PET/CT, gray-scale PET, and axial plane fused PET/CT at the level of the kidneys (left to right). Showing increased 18F-FDG uptake in the region of the left medial retropharyngeal lymph node mass, as well as the nasal tissues, nasopharynx, right lung, mediastinum, liver, and both kidneys. Histopathology post-mortem confirmed large-cell high-grade lymphoma causing increased uptake in the kidneys. The increased 18F-FDG uptake in the urinary bladder is a normal finding. The increased 18F-FDG uptake in the small intestine is likely due to normal digestion.


Gingival recession in tooth 4.1.


Removal of epithelial-connective tissue from the palate.


Epithelial-connective tissue graft.


Positioning the amniotic membrane at the donor site.


Horizontal mattress sutures.


Resolution of gingival recession 30 days after the procedure.


Reepithelialization of the palate 14 days after HAM grafting, before.


After. Removal of stitches.


Appearance of the palate 30 days after the procedure.


Thyroid FNA ThinPrep: On the left are the mesothelioma cells, which are in three-dimensional groupings compared to the Hurthle cell population on the right, that forms two dimensional sheets. The mesothelioma cells have waxy cytoplasm with multiple nucleoli and more nuclear variation. The Hurthle cell population has abundant granular cytoplasm and generally one nucleolus. Papanicolaou stain x600.


Surgical Resection: Panel A (x40) shows nodular thyroid tissue. Panel B (x40): Two populations of cells seen within the nodule. Hurthle cells (black arrow) shows abundant pink cytoplasm. However, the tissue contains mostly mesothelial cells (white arrow) which are smaller polygonal cells with less cytoplasm. Panel C (x100): Mesothelial cells are positive for keratin 5/6. Panel D (x100): Mesothelial cells are positive for calretinin. Other immunostains (not shown) that were positive in the mesothelial cells include CK7 and HBME1, while TTF-1 and Thyroglobulin were both negative.


A; Large tumor on the left side of the head (male, 79 years).


B-d The waxy tumor exhibited a sulcated, mostly yellowish and reddish surface, and in some areas hemorrhages. A punch biopsy showed amorphous eosinophilic material in the dermis (b), and these masses extended down to the subcutis.


Immunohistochemistry showed that the entire dermis and parts of the subcutis were filled with amyloid consisting of both kappa and lambda immunoglobulin light chains (c, d).


E; In electron microscopy, the typical amyloid fibrils (7-10 nm in diameter) were found (bar = 0.5 microm).


The patient at follow-up 1 month after surgery. He showed no signs of local tumor recurrence or systemic disease.


(a) Maximum intensity projection image - increased fluorodeoxyglucose avidity in the midline of the neck.


(b) Fused axial image - markedly increased metabolic activity in left-sided mass lesion (large single arrow). Another large solid-cystic mass lesion arising from the right lobe of the thyroid gland with mildly increased fluorodeoxyglucose uptake (small double arrow).


(c) Axial computed tomography scan of the neck - left-sided mass lesion is not separable from the isthmus of the thyroid, thyroid cartilage, and obstructing the supraglottic larynx.


(d) Small soft-tissue parenchymal nodules in the lingular segment of the left lung with minimally increased metabolic activity.


Axial section of follow-up positron emission tomography/computed tomography scan shows the partial regression of the metabolically active thyroid mass. The benign lesion in the right lobe of thyroid remains unchanged.


Anterior Posterior view of the right arm taken in the emergency department demonstrating significant subcutaneous free air.


Lateral view of the right arm taken in the emergency department demonstrating significant subcutaneous free air.


Coronal chest computerized tomography scan demonstrating subcutaneous free air throughout the chest secondary to a pneumothorax.


Axial chest computerized tomography scan demonstrating subcutaneous free air throughout the chest secondary to a pneumothorax.


Lateral view of the right arm taken eight days after initial presentation demonstrating resolution of subcutaneous free air.


(a) Fundus photo oculus dextrus showing disc edema and retinal straie.


(b) Fundus photo oculus sinister normal.


B-scan ultra sound oculus dextrus showing typical "T sign.


Fundus fluorescein angiogram oculus dextrus showing leak from disc.


(a) Magnetic resonance imaging brain and orbit - isointense diffuse thickening of right ocular coats.


(b) Magnetic resonance imaging brain and orbit - T1-weighted image with contrast - showing hyperintense diffuse thickening of the right ocular coats.


(c) Magnetic resonance imaging brain and orbit - T2-weighted image showing hypo intense diffuse thickening of right ocular coats.


(a) Fundus picture oculus dextrus posttreatment - absent disc edema retinal straie.


(b) Optical coherence tomography macula oculus dextrus - eye - flattening of retinal straie posttreatment.


Cut-surface of the mass shows whitish, nodular, round, glistening areas with yellow-brown soft areas in the centre.


FISH analyses with chromosomes 4 and 22 probes. . Notes: Image showing the results of FISH on a metaphase spread, with painting probes for chromosomes 4 (orange) and 22 (aqua). The yellow arrows indicate normal chromosome 4 (orange - in the upper), residual chromosome 4 (orange - in the middle) and chromosome 22 (aqua); the red arrow indicates derivative chromosome 4 (orange + aqua). . Abbreviation: FISH, fluorescence in situ hybridization.


Brain MRI in the 7th . FLAIR and DWI show a mass involving the right basal ganglia and thalamus (a, b).


Brain MRI in the 7th . The mass was clearly enhanced (c).


9th. Week after admission. Two weeks later, the mass had enlarged (d-f).


Postsalvage chemotherapy biopsy.


Soft, nontender compressible diffuse swelling involving the left parotid gland.


Simple magnetic resonance imaging of the neck.


Scanner view shows cystic cavity lined by thin epithelium and subjacent C. T with Germinal centers.


Highpower view of cystic cavity lined by thin epithelium & showing subjacent C. T with germinal centers.


High-power view showing cystic cavity lined by thin epithelium and subjacent connective tissue with germinal centers.


High-power magnification showing germinal centers with subjacent connective tissue.


Abdominal computed tomography after 3 months of treatment with everolimus showed stationary pancreatic neuroendocrine tumors.


White arrow) but decreasing liver metastasis nodule numbers , suggesting a partial response to everolimus.


FNAC smears showing cohesive clusters of small, uniform, ovoid to round epithelial cells (MGG, x100).


Preoperative Xray.


CT scan.


CT scan done during CT guided biopsy.


MRI showing the tumor compressing the cord.


MRI showing the tumor arising from the D7, D8, D9 vertebral levels.


Intraoperative image showing a friable tumor mass compressing the cord.


Excised tumor mass.


Histopathological slide showing polygonal stromal cells, osteoclastic giant cells and many hemosiderin laden macrophages on high power view.


Whole body fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) maximum intensity projection image.


Axial fused PET/CT showed a intense uptake in the soft-tissue lesion in the left breast.


Liver lesions.


Bone lesion.


Axial CT showing lytic bone lesion in D4 vertebra.


Immunohistochemistry staining showing positive for chromogranin.


Synaptophysin.


Midsagittal images of computed tomography scan of the lumbar spine.


Coronal imagining of the lumbar spine demonstrating a left L5 transverse process fracture.


Midsagittal imaging of the lumbar spine demonstrating a large fluid collection of subcutaneous tissue in the lumbar spine.


Coronal imaging of the lumbar spine, further demonstrating a large fluid collection of the lumbar spine subcutaneous tissue.


Extraoral view showing facial asymmetry.


Birds eye view showing deviated chin button toward right side.


Intraoral view showing enlargement of the maxilla and the mandible.


PNS view showing expansile, ill defined mixed radiopaque-radiolucent lesions in the frontal bone, ground glass radiopaque lesion in the right maxilla.


OPG showing extensive multilocular lesion of the right ascending ramus extending upto the mandibular left first molar.


Axial.


Sagittal. T1-weighted magnetic resonance imaging scans revealed a heterogeneous osteolytic mass in the right parietal region.


The lesion intensely enhanced after contrast administration in the axial.


Sagittal. T1-weighted magnetic resonance imaging scans.


Selected axial sections (a-c) of cranial computed tomography scans demonstrating the skull defect with associated large subgaleal and extradural hematoma.


Photomicrograph showing polymorphic infiltrate of Langerhans histiocytes (polygonal cells with kidney-shaped and elongated nuclei had longitudinal groove) admixed with many eosinophils.


Six-year follow computed tomography scan without.


With contrast. Demonstrating no recurrence and spontaneous bone formation and closure of the skull defect.


(a and b) A three-phase whole body 99mtechnetium labeled methylene diphosphanate bone scan showing focal hot spot in sacrum (arrow) with no increased vascularity. There were no other abnormal hot spots in rest of skeletal survey.


Myelo computerized tomography (CT) of pelvis. Initial and a 6-h delayed CT scans, revealed no free communication between the Tarlov cyst (TC) and subarachnoid space. However, surrounding sacral bony erosion around TC in S2 level produced the increased methylene diphosphanate uptake in the bone scan as a result of new bone formation.


Patient's pedigree. Arrow indicates proband. Proband's mother and husband are indicated by an asterisk. Only these family members were tested. 'N' means normal karyotypes. Only in proband both cytogenetic and FISH testing were performed.


Histological view of biopsy specimens obtained from. Surgical excision of the supraclavicular fossa lymph node.


Fiberoptic bronchoscopy. The two images show caseous necrosis, epithelioid cell nodules and Langhans giant cell. Magnification, x100.


Pretreatment clinical findings of periorbital necrobiotic xanthogranuloma demonstrating multiple yellow, firm papules coalescing into plaques and resulting in cicatricial lagophthalmos.


Skin biopsy of necrobiotic xanthogranuloma lesions revealing a diffuse dermal infiltrate of histiocytes with multinucleated giant cells along with cholesterol clefts, Touton forms, and geographic necrobiosis. Hematoxylin and eosin, x100.


Treatment outcome of periorbital lesions of necrobiotic xanthogranuloma after 16 cycles of intravenous immunoglobulin.


Composite photomicrographs. (a) Lesion with superficial epithelium and connective tissue stroma with numerous amelobastic follicles (x4 OM.


Composite photomicrographs. (b) Follicle showing ameloblast-like cells, stellate reticulum and dentinoid tissue (x10 OM.


Composite photomicrographs. (c) Numerous ameloblastic follicles seen with interspersed dentinoid-like material (x10 OM.


Composite photomicrographs. (d) Dentinoid secreted by odontoblast (x40 OM*). *Original magnification.


Anteroposterior and lateral radiograph of the right leg showing lytic lesion with large soft-tissue component and hair-on-end periosteal reaction in mid-diaphysis of tibia.


Left eye. Total ptosis.


Left eye. Total ophthalmoplegia.


(a) H and E-stained section of nasopharyngeal punch biopsy specimen showing nests of small round blue cells, (b) Strong CD99 immunoreactivity.


Single, non-tender, pedunculated, polypoid growth, about 6 x 7 cm, hanging from the left labium minus (P), and ,minimal swelling of the left labium majus.


Multiple "knife-cut" ulcers on the external genitalia, in the inguino-crural fold, and in the interlabial creases.


Multiple typical "knife-cut" ulcers on the external genitalia in the inguino-crural fold,. Interlabial creases.


Natal cleft.


Massive edema of genitalia more marked on the left labium majus.


Case 1: (a) Noncontrast computerised tomography axial images of 29-year-old male following road traffic accident developed intraparenchymal contusion (broad arrow) showing hemorrhagic contusion in right frontotemporoparietal lobe causing transfalcine herniation with midline shift. SDH was seen in right frontal region.


(b) Axial bone window sections showing fracture of right frontotemporoparietal bone (long arrow) with depressed fracture involving right orbital roof (not shown).


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. (a and b) Noncontrast computerised tomography showed two similar appearing well defined hyperdense lobulated mass.


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. (a and b) Noncontrast computerised tomography showed two similar appearing well defined hyperdense lobulated mass. One measuring approximately 2.2 cm x 1.5 cm around right sylvian fissure is seen abutting insular cortex with surrounding gliotic changes and another rounded hyperdense mass noted in right temporal lobe (long arrow in a and b).


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done.


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. Axial postcontrast brain sections showing prominent peripheral enhancement of lesions in insular cortex and temporal lobe (broad yellow arrow in c.


(a) MRI, T1W image showing hypointense lesion in the left frontal lobe.


(b and c) showing peripheral enhancement on contrast administration.


The vessels showing perivascular infiltrate of lymphocytes and neutrophils causing wall destruction. H and E, x100.


MR angiography in the postoperative period shows focal narrowing of vessels in the left frontal region, indicating vasculitis.


Necrotizing fasciitis of the patient's left leg at admission. Note violet purpuras with unclear margins and bullae of lateral malleolar area.


Intra-operative findings:. Right hand.


Left lower leg. It was easy to separate the fascia from the subcutaneous tissue.


Histopathological findings of the soft tissue. (A) The subcutaneous fat tissues showed edematous changes and infiltrates of inflammatory cells mixed with neutrophils (H&E stain, x 100).


Histopathological findings of the soft tissue. (B) It shows inflammatory infiltration and thrombosis in the blood vessels (H&E stain, x 400).


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (A) Pedigree of the family: electropherograms depict the relevant sequence section around the causative C-to-T transition at position c.3028 in exon 23 and the generation of a premature stop codon at position p. Q1010.


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (B) Physical features and final height (133 cm) of the patient (reproduction with permission of the patient).


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (C) Chest CT demonstrates bronchiolitis obliterans, lower lobe right side: small area of ground-glass opaque consolidation, swelling, and widening of bronchial tubes.


Medical image.


Lateral. Radiograph demonstrating hardware failure and destruction of the tibiotalar joint with severe valgus deformity and non-union.


Lateral. Radiographs following removal of hardware, placement of tibiotalar antibiotic spacer and ringed external fixator.


Lateral. Radiographs following definitive ankle fusion after eradication of infection.


Right lower extremity (A-C) following successful infection eradication and tibiotalar fusion demonstrating healing of prior surgical sites and sinus tracts.


Preprocedural presentation of the patient.


Micro-retention beads sprinkled on wax pattern.


Bresol investment liquid and investment material.


Seven grams of polyetheretherketone dental material.


For2Press unit used for vacuum pressing the material.


Polyetheretherketone framework try in.


Postcementation.


O. P. G. Revealing bone loss from the alveolar ridge on the right side.


Excised specimen.


Post operative healing after 7 days.


Photomicrograph.


Intra oral growth.


Extra oral view.


Computed tomography images of the patient. A; Nonenhanced computed tomography image.


Computed tomography images of the patient. B; Arterial phase.


Computed tomography images of the patient. C; Venous phase.


Computed tomography images of the patient. D; Delayed phase.


Medical image.


Immunohistochemistry. For CD79a.


Digital subtraction angiography image showing mild stenosis in the thoracic aortic lesion without an obvious intimal flap.


The implanted stent.


Axial nonenhanced CT image.


CTA. Showing enlargement of the false lumen three months after stent implantation, with nonhomogeneous enhancement and mediastinal extensions of the false lumen, which was interpreted by radiologists in our hospital and other medical centers during follow-up as an endoleak and periaortic hematoma.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. T1WI image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. Contrast-enhanced T1WI image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. Showing a nonhomogeneous enhancement of the "false lumen," which correspond to the hyperintense regions in DWI (b = 800 s/mm2) image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. T2WI image. Showing the heterogeneous of "false lumen" with bleeding area (green arrow).


Histopathology of aortic tissues showed that the tumor was composed of malignant spindle cells and demonstrated nuclear pleomorphism and atypia (hematoxylin and eosin staining x200).


Frontal view of fluoroscopic images during inguinal injection of Lipiodol. At abdominal level there is opacification of lymph vessels with drainage of Lipiodol into the cysterna chyli and thoracic duct (TD). Image of occlusion of the TD on the passage from abdominal to thoracic level. Black arrow: droplets of ethiodized oil at the passage from the inferior caval vein to the TCPC conduit, revealing early lymphovenous shunting. At thoracic level there is drainage of Lipiodol through multiple collaterals to hilar, peribronchial, mediastinal, and axillar dilated lymph vessels. Right mediastinum is more affected than the left.


Cone-beam computed tomography image during Lipiodol-based lymphangiography shows filling of several mediastinal abnormal dilated lymph vessels, predominantly peribronchial right (yellow arrows). This is similar to the fluoroscopic image of Figure 1.


Operative procedure. A; The hilar Glissonean pedicle was taped to clamp the inflow from the proper hepatic artery without cystic artery flow.


Operative procedure. B; Under ICG mode, the stained area of the hepatic parenchyma was marked by electrocautery to identify the perfusion area of the cystic vein.


Operative procedure. C; Extended cholecystectomy was performed along the demarcation line.


Operative procedure. D; We performed lymphadenectomy of the hepatoduodenal ligament. ICG, indocyanine green.


CT for head segment.


Clinical image of eccrine spiradenoma presenting as erythematous nodule on the scalp.


Trichoscopy of eccrine spiradenoma showing "serpentine-like" linear reddish structure (yellow arrow) surrounded by whitish areas (black arrows).


Partial karyotype of Normal Chromosome and Abnormal chromosome 6 with Ideogram of normal Chromosome 6.


Giemsa Banded Karyotype image of wife.


Giemsa Banded Karyotype image of Husband.


Partial karyotype of normal and abnormal chromosome 1 and 9 and normal chromosome ideogram respectively.


Abdominal ultrasound of the patient. . A hyperechogenic 5.6 x 7.3 cm anchor is observed in segment V of the right hepatic lobe suggestive of an incidental hemangioma.


Myelolipoma evaluation. . Surgical specimen, macroscopic. Amado Polyclinic, Maracaibo- Edo Zulia (10/04/2013).


Medical image.


Show generalized diffuse scleritis with scleral abscess inferotemporal area.


A scleral tissue biopsy showing mucosal erosion and submucosal fibrosis with necrobiosis of collagen and sheets of mononucleated foamy histiocytes (xanthoma cells), infiltrating the submucosal fibrous tissue, accompanied by variable numbers of dispersed lymphocytes and plasma cells (hematoxylin-eosin; original magnification: x40).


Another scleral tissue biopsy predominantly containing fibrosis with necrobiosis of collagen and scattered necrotic cellular debris of inflammatory cells (hematoxylin-eosin; original magnification: x200).


Sheets of xanthoma cells and scattered hemosiderin- laden macrophages, neutrophils, lymphocytes, plasma cells, and erythrocytes. The xanthoma cells have small, round nuclei and abundant clear or vacuolated cytoplasm (hematoxylin-eosin; original magnification: x400).


Some of infiltrating histiocytes show hemophagocytic activity characterized by intracytoplasmic nuclear debris (hematoxylin-eosin; original magnification: x400).


Small- and medium-sized vasculitis characterized by lymphocytic and neutrophilic infiltrate in wall of subcutaneous vessels obtained from sural nerve biopsy (hematoxylin-eosin; original magnification: x200).


Axial view of the patient's computed tomography sca. Contrast-enhanced computed tomography.


Axial view of the patient's computed tomography sca. Bone window.


Intraoperative findings of the lesion. The tumor was noted to have a well-demarcated fibrous outer capsule, with erosion of the pericranium, and ,tight dura adherence.


Intraoperative findings of the lesion. The lesion received its main blood supply from the engorged middle meningeal artery.


Intraoperative findings of the lesion. Superior view of the lesion.


Intraoperative findings of the lesion. Inferior view of the lesion.


Anteroposterior radiograph of index finger showing soft tissue swelling but no bony involvement.


Gross histological specimen measuring 2.1cm x 1.5 cm x 1.5 cm.


Abundant giant cells, foamy macrophages, and spindle cells in the background of collagen bundle.


Sheets of mononuclear cells mixed with foamy macrophages and focal presence of osteoclastic type multinucleate cells evenly distributed in the fibrotic stroma.


Fournier's gangrene involving the anterior scrotum before debridement.


Integra placement over the scrotal defect.


The incorporated Integra following removal of the outer silicone sheet at the time of split-thickness skin-graft placement, 2 weeks following initial Integra placement.


Well-healed skin graft, 1 week following skin-graft placement.


Well-healed skin graft, 3 weeks following skin-graft placement.


CT scan of a patient with an SPT. Abdominal contrast-enhanced CT scan shows an enlarged pancreatic head containing a well-defined, encapsulated solid cystic mass about 4 cm in diameter (arrow). CT, computed tomography; SPT, solid pseudopapillary tumor.


Gross examination of an SPT. Photograph of the.


Gross examination of an SPT. Gross specimen shows the. Smoothly encapsulated tumor with areas of necrosis and hemorrhage. The ruler shows distance in centimeters.


The immunohistochemical features of an SPT. The tumor cells showed positive for. Vimentin.


The immunohistochemical features of an SPT. CD10.


The immunohistochemical features of an SPT. Alpha-antichymotrypsin.


The immunohistochemical features of an SPT. Alpha-antitrypsin.


The immunohistochemical features of an SPT. Beta-catenin.


The immunohistochemical features of an SPT. Neuron-specific enolase.


The immunohistochemical features of an SPT. Synaptophysin.


The immunohistochemical features of an SPT. Progesterone receptor.


A gray-scale ultrasound image shows a well-defined circumscribed ovoid heteroechogenic placental mass with a 4.99 cm diameter. . Note: The mass protrudes from the fetal surface of the placenta and is in contact with the amniotic cavity.


A gray-scale ultrasound image shows the protruding placental mass into the amniotic cavity from a placenta with the thickest anteroposterior diameter of 5.5 cm.


Macroscopic appearance of the placenta after normal vaginal delivery. . Note: A 5-cm-diameter mass on the fetal surface of the placenta near its edge is shown.


The atypical marginal location of the placental chorioangioma near the placental edge.


(a) The clinical image irregular asymmetric lump in the medial aspect of the left nipple-areolar complex.


(b) Ultrasonography image: Heterogeneous lesion with multiple hypoechoic areas and internal moving echoes was noted.


(c) Giemsa stain (x200): Smears show polymorphs and mature squamous cells.


(d) Pap stain (x200): Smear shows a multinucleated foreign body type of giant cell.


Plain and contrast-enhanced computerized tomography showing the hilar Bosniak type 4 cyst with enhancing soft-tissue component (arrow).


Intraoperative picture showing the grayish tumor closely adherent to renal vessels.


Tumor cells staining negatively for Hale's colloidal iron stain (x40).


Axial CT image of the pelvis demonstrates a large fat containing mass within the presacral region (arrowheads). Fat within the mass is dark on the CT images (arrow).


Axial nonfat saturated . Bright fat on nonfat saturated image.


Fat saturated. T2-weighted MRI images of the pelvis also demonstrates a large fat containing mass within the presacral region (arrowheads). Saturates out on the fat saturated image. (arrows).


Clinical photograph showing diffuse scrotal swelling.


A; Axial CT image of the chest showing pneumomediastinum along with subcutaneous emphysema involving the chest wall on the left side.


B; Axial CT of the abdomen showing pneumoretroperitoneum surrounding the right kidney along with subcutaneous emphysema.


Optical coherence tomography angiography (OCTA) with the right eye represented by the right column.


The left eye by the left column The structural slabs a, b of the lesions in both eyes were obtained using an RPE-RPE fit segmentation.


Optical coherence tomography angiography (OCTA) with the right eye represented by the right column En face OCTA with customized segmentation between RPE and Bruch's membrane shows a type 1 neovascular network with evident aneurysmal dilatation, as demarcated by the crossing blue and green lines (c, d). Dense B-scan with angiographic flow overlay e, f demonstrates the corresponding cross-sectional view and the customized segmentation of the respective lesions.


The left eye by the left column The structural slabs a, b of the lesions in both eyes were obtained using an RPE-RPE fit segmentation. En face OCTA with customized segmentation between RPE and Bruch's membrane shows a type 1 neovascular network with evident aneurysmal dilatation, as demarcated by the crossing blue and green lines (c, d). Dense B-scan with angiographic flow overlay e, f demonstrates the corresponding cross-sectional view and the customized segmentation of the respective lesions.


Chest radiography revealed consolidation in the right lower lung field at the initial visit.


Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


Reddish and ulcerated lesion in the left great toe.


Histopathological findings. (a) Low-magnification view showing the architecture with ulcerated epidermis.


Histopathological findings. (b) High-magnification view showing myofibroblastic and fibrovascular proliferations, with mature woven bone rimmed by osteoblasts. No evidence of abnormal mitotic activity or cellular atypia was observed.


Follow-up image showing no recurrence of the mass after 6 months.


Preoperative photograph of the patient, taken anteriorly.


T1 weighted contrast bilateral breast MRI demonstrating a soft tissue intensity mass-like area attached to the right breast capsule with internal enhancing foci and trace periprosthetic fluid, in addition to enhancing foci at the deep margin of the left breast capsule.


Intraoperative photograph of bilateral explanted, textured, silicone breast prostheses and right breast capsule. There is evidence of bilateral rupture with hematoma within the implants.


Immunohistochemistry for CD68, a histocyte marker, highlights numerous foam histocytes within the lesion on the external surface of the right capsule.


This image shows vacuolated histiocytes and a foreign body-type giant cell, features of the silicone granuloma taken from the lesion on the external surface of the right capsule.


Intact insular aggregates of small cells amidst fibrovascular stroma (Pap, x100) with (inset) an intact insula enveloped by a single layer of endothelial cells (Pap, x400).


Cellular smears containing pleomorphic cells having very large nuclei (monster cells) with scanty cytoplasm. Few of the nuclei revealing nucleoli (Giemsa, x400).


Lesional cells revealed positive staining for vimentin (IHC, x200).


Renal biopsy specimen from the patient with serum creatinine of 1.98 mg/dL. A proximal tubule with denuded epithelium, exfoliating brush borders (black arrows) and mitotic figure (white arrow) is shown (x 400).


Preoperative view.


Suture placement (Intraoperative).


Post suture placement.


Postoperative day 100.


CT from March 1, 2018 shows extensive ascites with small bowel clumped from mesenteric retraction by cancer.


Case 1. Pre-chemotherapy imaging findings. The tumor was 2 cm in size.


Case 1. Pre-chemotherapy imaging findings. And had a maximum standardized uptake value (SUVmax) of 5.1 in positron emission tomography findings.


Preoperative magnetic resonance imaging views of the patient (a) Sagittal T1-weighted cerebral magnetic resonance imaging showing a third ventricular colloid cyst and significant hydrocephalus with ballooning of the corpus callosum.


(b) Axial T1 view of the same patient.


Gammknife plan summary showing axial, coronal and sagittal T1 weighted with contrast MRI views. 13 Gy at 65% was prescribed.


43 months Postoperative and Postradiosurgical Gammaknife treatment MRI views (a) Sagital T1 weighted cerebral MRI showing that the third ventricular colloid cyst has remained essentially the same with complete resolution of the hydrocephalus. Corpus callosum with normal thickness.


(b) Axial T1 views of the same patient.


Clinical photographs of the patient with 1p36 triplication. (A) Front view of the face.


Clinical photographs of the patient with 1p36 triplication. (B) Lateral view of the face. The major facial phenotype included strabismus, hypertelorism, low hairline, ear malformations, broad nasal bridge, wide mouth, thick lips and prominent incisors.


Fundus appearance of the right eye showing multifocal retinal opacities and superficial retinal hemorrhages involving the posterior pole. There is an associated optic disc swelling and mild vitritis.


Photomicrographs showing multinucleated giant cells shown by arrow, large number of elongated cells lying singly and clusters (Giemsa, x400).


Timeline for blood pressure and BMI of the patient. (A) The blood pressure and BMI of the patient during the follow-up are showcased as a timeline.


Timeline for blood pressure and BMI of the patient. (B) The blood pressure of the patient indicated as the mean arterial pressure had been maintained normal without anti-hypertensive drug treatment postoperatively.


Timeline for blood pressure and BMI of the patient. (C) BMI of the patient decreased lower than preoperative level 2 weeks postoperatively and then recovered 3 months after the operation.


T2 FLAIR image showing bilateral medial temporal hyperintensity. FLAIR = Fluid-attenuated inversion recovery.


FA of the patient's right eye taken over a 2-year period. . Notes: (A and B) Initial visit (early phase of FA of the right eye reveals a small irregular hyperfluorescence area inferonasal to the fovea with late-phase leakage that corresponds to the juxtamacular CNV lesion; arrows).


FA of the patient's right eye taken over a 2-year period. (C and D) One week after cessation of steroid therapy (a fulminant recurrence and development of CNV membrane with involvement of the fovea; arrows).


FA of the patient's right eye taken over a 2-year period. (E and F) Three months after PDT (progressive enlargement of CNV membrane).


FA of the patient's right eye taken over a 2-year period. (G) Recurrent activity of CNV membrane 8 months after the second intravitreal ranibizumab injection (circle).


FA of the patient's right eye taken over a 2-year period. (H) Two months after periocular triamcinolone injection combined with intravitreal ranibizumab injection (almost complete regression of active CNV membrane). . Abbreviations: CNV, choroidal neovascular membrane; FA, fluorescein angiography; PDT, photodynamic therapy.


Metastases of ductal carcinoma breast (WD) (fine-needle aspiration cytology) malignant cells in ductal configuration, (Pap stain, x40).


Metastases of ductal carcinoma breast (WD) (fine-needle aspiration cytology) malignant ductal cells in sheets with cellular discohesion and attempted internal ducts, (Pap stain, x40).


Metastases of melanocarcinoma (fine-needle aspiration cytology) dissociated round to polygonal melanocytes showing prominent nucleoli, binucleation and cytoplasmic fine melanin pigments, background shows melanin containing macrophages (Giemsa stain, x40).


Metastases of small cell carcinoma lung (fine-needle aspiration cytology) nested population of small to intermediate size cell with high N: C, nuclei show pepper salt chromatin and significant nuclear fragility (Giemsa stain, x40).


Metastases of clear cell renal cell carcinoma (fine-needle aspiration cytology) Sheet and tubular structures of cuboidal epithelial cells with low-grade malignant nuclei and cytoplasmic fine vacuoles, (Pap stain, x40).


T2 weighted MRI showing an expansile lesion involving C2 vertebra with cord compression.


Patient showing NF with eschar formation in upper eyelid in the right eye at the day of admission at the hospital. NF, necrotizing fasciitis.


Tomography presenting preseptal edema and heterogeneous fluid, suggesting abscess in the right eyelid.


Patient presenting the upper eyelid aspect of the right eye minutes after the debridement.


Upper eyelid aspect after 15 days of the debridement.


Upper eyelid aspect after 2 months of debridement with closed.


Opened. Eyes.


(a) OCT macula.


(b and c) GCL OCT.


(d) OCT optic nerve. Stable condition from four months to one year of treatment, some recovery of ANFL from the initial drop after four months.


(a) CT scan showing swellings in the lymph nodes (arrows).


(b) Low-density areas in the spleen were also observed (arrows), suggesting metastasis from a malignant tumor of the left ovary.


18FDG avidity was observed in the lymph nodes (arrows).


In the spleen (arrows).


(a) Microscopic findings of the resected ovarian tumor and lymph nodes. Atypical cells with clear cytoplasm grew papillary, tubulocystic, and focally solid pattern (hematoxylin and eosin [HE.


(b) Non-caseating epithelioid granulomas were observed in the pelvic lymph node as well as in the spleen where there were no metastatic lesions (HE).


Bacilloscopy of smear showing positive bacillus (black arrow).


(A) Synovial fluid aspiration from the interphalangeal joint of the hand.


(B) Acid-fast staining of synovial material from the interphalangeal joint of the hand showed numerous acid-fast bacilli (black arrow).


The image shows a 17 mm high intensity area in the pons on T2-weighted.


Diffusion-weighted. Magnetic resonance imaging (MRI) of the brain.


Pathological specimens. . Notes: (A) Skin biopsy specimen taken from the lower abdomen reveals proliferation of large lymphoma cells filling the vessels of hypodermic adipose tissue. Hematoxylin and eosin staining; magnification.


Pathological specimens. (B) Numerous lymphoma cells with irregular nuclear contours and large nucleoli clustered are seen in small vessel lumens. X40. X100.


Magnetic resonance imaging (MRI) of the brain after receiving chemotherapy. . Notes: Pontine lesion on T2-weighted.


Magnetic resonance imaging (MRI) of the brain after receiving chemotherapy. Diffusion-weighted. MRI of the brain completely resolved after eight cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.


Transthoracic echocardiography (four-chamber view) showing an echogenic mass attached to the posterior leaflet of the mitral valve (MV) measuring 2.3 cm x 1.3 cm.


Intraoperative transesophegeal echocardiography (color flow Doppler, four-chamber view) showing prosthetic MV repair with severe mitral regurgitation jet.


Pictograph of mitral annuloplasty ring with remnant vegetation and part of the excised native mitral leaflet.


(a) Sagittal T1-W MRI without contrast injection, before the first surgery. An extradural hyposignal lesion is observed at S1-S3 level, which was neglected in the first intervention.


(b) Sagittal T1 MRI with contrast from the lumbosacral region after the first operation. Homogenous enhancement of the lesion is observed.


(c and d) Axial T1 MRI views of the lesion with and without contrast, after the first operation.


(A) CT revealed large dense shadows and cavity formation in the inferior lobe of the left lung.


(B) The results of CT re-examination suggested that, the area of infection in the inferior lobe of the left lung was significantly reduced and the cavity was smaller.


(C) The condition of the lung was further improved than before.


(A) The opening of the left lower lobe is narrow.


(B and C) There is a big and white neoplasm in the lower left lung, with a lot of white necrotic material in the subsegment.


Biopsy revealed chronic inflammation of bronchial mucosa with lymphoid follicular hyperplasia, but no definite tumor cells (400X).


Contrast-enhanced T1-weighted sequences show the brain abscess in the right parietal lobe.


Diffusion-weighted magnetic resonance imaging.


(a, b) Surgical site after durotomy. No pathological alteration of the brain surface under white light.


(a, b) Surgical site after durotomy. , intense fluorescent staining under YE560.


(a, b) Surgical site after opening of the abscess. Drainage of pus under white light.


(a, b) Surgical site after opening of the abscess. And under YE560 Note the nonfluorescence of the pus.


Radiography at eight years post-trauma.


Spherical bur to access the root apical area of the 11.


Apical lesion (granulation tissue) removed from maxillary central incisor.


Granulation tissue for histopathological analysis.


Radiography at six months after surgical procedure.


Follow-up radiography at 53 months from surgical procedure.


Ocular findings at presentation. . Notes:. Ciliary injection, corneal epithelial edema, mutton-fat keratic.


Ocular findings at presentation. . Notes: infiltrating cells in the anterior chamber of the right eye.


Ocular findings at presentation. ;. Pigmentation of the trabecular pigment band in the angle was increased in the right eye.


Ocular findings at presentation. ;. Compared with the left eye.


Ocular findings observed after treatment was started. . Note: Distorted pupil and fan-shaped iris atrophy were observed.


MRI of the patient's abdominal cavity (without contrast). (A) In the upper pole of the right kidney, the lesion of an irregular shape and inhomogeneous structure was connected with the pelvicalyceal system, coronal projection, SSFP mode.


MRI of the patient's abdominal cavity (without contrast). (B) The lesion had an irregular shape and a bumpy surface, 3D-reconstruction from the SSFP series.


MRI of the patient's abdominal cavity (without contrast). (C-E) The multinodular nature of the lesion and clear boundaries were determined in axial sections, T1 mode.


Fragments of the kidney and cystic lesion. Gross evaluation (A,B) demonstrates cystic lesion with adjacent renal parenchyma (p) separated by septa with varying wall thickness. Adhesions tightly connected the lesion with the kidney capsule and adjacent adipose tissue. The lumen was filled with gray-brown cheesy keratinized masses (k). It was connected to the small renal calyx (c) with the isthmus (i). Mucosa of the calyx was gray, smooth, with single overlays of horny masses.


Fragments of the kidney and cystic lesion. (C) The histological study revealed keratinized mass in the lumen of the lesion.


Fragments of the kidney and cystic lesion. (D) The renal parenchyma was separated from the cyst wall with adipose tissue of the renal sinus.


Fragments of the kidney and cystic lesion. (E,F) Three types of epithelium lined the cyst wall: stratified squamous epithelium (sq) with a developed granular layer and hyperkeratosis, urothelium (ur) and simple cuboidal epithelium (cub).


Fragments of the kidney and cystic lesion. (G) We also detected the focuses of chronic inflammatory infiltration.


Fragments of the kidney and cystic lesion. (H) Atrophic renal parenchyma was adjacent to the epithelial lining in some areas.


Immunohistochemical study of kidney cystic lesion. The cyst wall areas contained numerous smooth muscle cells.


Immunohistochemical study of kidney cystic lesion. , singular cells.


Immunohistochemical study of kidney cystic lesion. Or completely lacked the cells.


Immunohistochemical study of kidney cystic lesion. (D-F) The cuboidal epithelium, urothelium and epithelium of the kidney tubules were strongly positive for CK7, while the stratified squamous epithelium did not express the marker.


Immunohistochemical study of kidney cystic lesion. (G-I) The urothelium was positive for uroplakin III, while the cuboidal epithelium expressed this marker weakly and irregularly.


Immunohistochemical study of kidney cystic lesion. (J-L) The multilayer squamous epithelium and tubule epithelium were not stained with antibodies against uroplakin III, but expressed p63. The cuboidal cyst epithelium had weak and focal positive expression of p63, the epithelium of the tubules was not stained.


Photos of the patient before and after 6 cycles of neoadjuvant chemotherapy. (A) Before neoadjuvant chemotherapy, the skin of the left breast was mildly inflamed; the left nipple was inverted; and a hard, palpable mass was present in the left central breast.


Photos of the patient before and after 6 cycles of neoadjuvant chemotherapy. (B) After 6 cycles of chemotherapy, the size of the mass in the left breast was significantly reduced. Drawings show the lesion of interest.


Ultrasound (US) imaging of the left breast and left axilla. (A) Before neoadjuvant chemotherapy, US examination of the left breast mass showed a hypoechoic lesion with inhomogeneous internal echoes.


Ultrasound (US) imaging of the left breast and left axilla. (B) US of left axillary lymph nodes before neoadjuvant chemotherapy showed enlargement and cortical thickening.


Ultrasound (US) imaging of the left breast and left axilla. (C) After 6 cycles of chemotherapy, the size of the mass was significantly reduced.


Ultrasound (US) imaging of the left breast and left axilla. (D) Lymph node size was reduced and the shape nearly returned to normal after chemotherapy.


Magnetic resonance imaging (MRI) before and after chemotherapy. (A) Diffusion-weighted imaging (DWI) before chemotherapy. The signal in the left breast and inner side of the right breast showed heterogeneous enhancement.


Magnetic resonance imaging (MRI) before and after chemotherapy. (B) Arterial phase of enhanced MRI before chemotherapy. Both breasts were composed of asymmetrically distributed dense glands. The whole left breast was markedly enhanced.


Magnetic resonance imaging (MRI) before and after chemotherapy. (C) Time-intensity curve of dynamic contrast enhancement of left breast mass before chemotherapy (outflow type).


Magnetic resonance imaging (MRI) before and after chemotherapy. (D) DWI after chemotherapy. The signal in the left breast and inner side of the right breast showed heterogeneous enhancement that was weaker than before chemotherapy.


Magnetic resonance imaging (MRI) before and after chemotherapy. (E) Arterial phase of enhanced MRI after chemotherapy. Compared to before chemotherapy, the size of lesions in the left breast and upper quadrant of the right breast were significantly reduced.


Magnetic resonance imaging (MRI) before and after chemotherapy. (F) Time-intensity curve of dynamic contrast enhancement in the left breast mass after chemotherapy (plateau type).


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (A) Left breast biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (B) Right breast biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (C) Epithelial membrane antigen (EMA) in left lymph node biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). After chemotherapy,. There were fewer cancer cells in the left breast , while interstitial fibrosis, nuclear enlargement, vacuolation, and number of cells with eosinophilic cytoplasm were increased.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). After chemotherapy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (F) Inflammatory cell infiltration after chemotherapy.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). HER2 positivity of left.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Right. Breast cancers as detected by IHC.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Monosomy of chromosome 17 of left.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Right. Breast cancers detected by FISH.


CT scan of the chest from Day 2 of the 1st hospitalization, showing diffuse ground-glass attenuation and consolidation of the lungs with lower lobe predominance.


CT chest from Day 1 of 2nd admission showing airspace opacities with cavitation.


CT neck image from Day 1 of 2nd admission showing filling defect in R internal jugular vein (denoted by arrow), suggestive of septic thrombophlebitis and Lemierre Syndrome in the setting of Fusobacterium necrophorum bacteremia.


Dual tracer positron emission tomography and computed tomography scan (18F-fluorodeoxyglucose positron emission tomography and computed tomography and 68Ga-DOTATATE positron emission tomography and computed tomography) showing both somatostatin receptor expressing and fluorodeoxyglucose avid hypodense liver lesions, largest in segment IVa and IVb measuring 6.6 x 5.0 cm with SUVmax (18F-fluorodeoxyglucose)-21.3 (panel A) and SUVmax (68Ga-DOTATATE)-33 (panel B).


Dual tracer positron emission tomography and computed tomography evaluation (18F-fluorodeoxyglucose and 68Ga-DOTATATE) demonstrates the progression of disease with fluorodeoxyglucose avid lesions of the lower third part of the esophagus (now measuring approximately 4.5 cm), multiple hypodense liver lesions (largest measuring 7.2 cm x 7 cm), multiple abdominal enlarged lymph nodes (largest perigastric lymph node measuring 4.1 cm x 2.9 cm) all showing more avidity on 18F fluorodeoxyglucose scan (panel A) compared to 68Ga-DOTATATE positron emission tomography and computed tomography (panel B).


(B) Interphase FISH analysis of case 2 using the dual-color BCL3 probe. FISH results demonstrated two intact red/green fusion signals, and 2 red and 2 green split signals, which indicated BCL3 gene break-apart. (Yellow arrows pointed to split signals of the rearranged gene).


Kidney biopsy showing a glomerulus with cellular crescent formation (H & E stain; 400x).


Kidney biopsy showing interstitial infiltrate of atypical lymphocytes (H & E stain; 100x).


Hypermucoviscous Klebsiella pneumoniae colonies with positive string test.


Bronchoscopy and ultrasound imaging of an abscess. (A,B) Right middle and left lower bronchoscopy, respectively.


Bronchoscopy and ultrasound imaging of an abscess. (C) Ultrasound imaging of an abscess in the left upper arm.


Timeline with relevant data from the case in our hospital; curves of body temperature and leukocyte counts. The arrows below indicate major events. Blue line shows body temperature values. Orange line shows leukocyte counts. TMP-SMX, trimethoprim-sulfamethoxazole; mNGS, metagenomic next-generation sequencing.


The present patient, a 29-year-old female.


Duodenal biopsies. (A) Hematoxylin and eosin staining shows normal duodenal mucosa without villous atrophy.


Duodenal biopsies. (B) CgA immunostaining of the duodenal biopsy shows complete loss of EE cells.


Duodenal biopsies. (C) Normal control duodenal mucosa immunostained with CgA, showing EE cell distribution in the crypt epithelium.


Duodenal biopsies. (D) Repeated biopsy shows normal immunostained CgA duodenal mucosa.


Extra-orally the swellings appeared ovoid in shape, with well-defined borders.


The orthopantamograph revealed multiple impacted teeth in the mandilble (red arrows) with multiloculated osteolytic lesions involving mandible and maxilla (blue arrows).


3-Dimensional computed tomography scan showing multiloculated cystic lesions affecting the body and rami of the mandible (blue arrows) and maxilla with raised orbital floor (red arrows).


Microscopy revealed highly cellular stroma consisting of plenty of multinucleated giant cells (black arrow). The cellular stroma consists of spindle cell fibroblasts with vesicular nuclei arranged in fascicles (blue arrow).


Surgical specimen showing decorticated and curetted material along with impacted teeth.


Two-year postoperative follow-up photograph with acceptable esthetics.


Craniocaudal.


Mediolateral. Radiographs of the right elbow. Note the smoothly marginated bony proliferation arising from the craniodistolateral humerus. Post-contrast transverse computed tomographic image of the right distal humerus.


Three-dimensional reformatted CT imaged displayed in a bone window.


Lateromedial post-contrast transverse computed tomographic image of the right distal humerus. Note the lobular mineral proliferation arising from the craniodistolateral humeral metaphyseal cortex and lack of underlying humeral bone lysis.


Left lateral thoracic radiograph (E): 5mm rounded nodule within the dorsal third intercostal space (white arrow).


Transverse lung window.


Dorsal reformatted bone window. CT showing the pulmonary nodule within the right cranial lung lobe (black and white arrows).


The thin, mineralized rim with a soft tissue center is evident on the enlarged transverse CT image displayed in a bone window (H).


Transverse.


Dorsal. Plane CT images in a bone window of the right elbow from repeat CT scan 217 days after completion of SBRT. Note that the soft tissue portions of the mass are more mineralized and the humeral cortex remains intact.


Macroscopic view of the 2.0-cm subcutaneous tumor on the right elbow.


A-c Cell morphology of the primary and recurrent tumors. A; The primary tumor showed irregularly arranged collagen fibers mixed with scattered proliferating fibroblast.


B; The first recurrent tumor, composed of slimmer spindle cells.


C; The second recurrent tumor, composed of slimmer spindle cells. Cells in the recurrent tumors were more monomorphic and showed higher cellularity.


D-f Immunostaining for Ki-67. The Ki-67 labeling index of the primary tumor was 2% ,that of the first.


Second recurrent tumors 10.


7% , respectively.


Skin colored, lobulated mass over the tip and dorsum of nose.


T1 MRI axial images show the stability of the colloid cyst within the third ventricle, followed by regression images were acquired in July 2015.


August 2017.


August 2019 The cyst measured 5 mm initially and at follow-up scans 2 years later, and 2.5-3 mm at his follow-up scan in 2019. The 2019 scan also shows hyperintense signal in the cyst, suggesting colloid cyst involution.


Mutation analysis and identification of the c.1858+1G>T mutation of the CSF1R gene. (A) Sequence chromatograms from parts of the CSF1R gene of this case. It displays a splice-site mutation (c.1858+1G>T) in intron 13 of CSF1R.


Mutation analysis and identification of the c.1858+1G>T mutation of the CSF1R gene. (B) Pedigree of the family studied in this report. The affected individuals are indicated with filled squares and circles. The proband is indicated with an arrow. A plus sign indicates that DNA was examined for the CSF1R sequencing analysis.


Histopathology of affected lymph node of case 1 (A,B): Patchy circumscribed areas with eosinophilic fibrinoid necrosis in the paracortex and cortex and absence of granulocytes in the areas of necrosis are shown. A variety of cells surround the necrotic area, and a large number of apoptotic cell fragments exist outside the cells.


Diagnosis of Legionella pneumophila infection using mNGS. (A) The majority of reads mapped to the L. Pneumophila genome with coverage of 28.12.


Diagnosis of Legionella pneumophila infection using mNGS. (B) The majority of reads mapped to the L. Pneumophila genome with coverage of 13.35.


(A,B) Gram stain of bronchoalveolar lavage fluid (BALF) with arrows indicating Legionella pneumophila, magnification x1,000.


(D) Gram stain of L. Pneumophila colonies (magnification x1,000).


Patient's hair at diagnosis of Crohn's disease.


Patient's hair one year after treatment.


Control abdominal CT showing left adrenal gland metastasis.


Comparison of cross-sectional chest CT images obtained from the patient at different time points. A1-4 October 5th, 2020: The day of admission; B1-4 Eighth day after admission on October 13th, 2020; C1-4 October 22nd, 2020 The day of discharge; D1-4 November 14th, 2020 20 days after discharge; E1-4 February 6th, 2021 Nearly 4 months after discharge.


A flow chart describing the patient diagnosis process.


Photograph of the patient's subcutaneous hemorrhage.


Hess chart (orbital Burkitt lymphoma: an aggressive presentation).


Orbital magnetic resonance imaging of axial.


Coronal. At the first medical examination. White arrows indicate a tumor of the lacrimal gland.


Pathologic examination and tissue immunostaining of the tumor. Hematoxylin, and ,eosin stain (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with CD20 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with MiB1 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with CD10 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with Bcl-6 (original magnification x400).


Image of the dilated fundus of the right eye shows an elevated amelanotic yellow-creamy lesion located in the posterior pole (greater diameter of 4 disc diameter [DD]) with focal round pigmented lesion of 1 DD located superotemporally to the optic nerve. There is also a more peripheral amelanotic lesion extending from 6 to 9 o'clock clockwise inferotemporally.


Macular optical coherence tomography (OCT) examination shows the elevated choroidal lesion (*) associated with exudative changes (subretinal fluid [#] and intraretinal cysts [^]).


An ultrasound of the right eye shows diffuse choroidal thickening (*). There is also a small elevated lesion (#) (<2 mm) located at the macula.


The choroid biopsy shows a dense lymphoplasmacytic infiltrate composed of a majority of small lymphocytes with a slightly irregular nucleus, occasional blasts, and a minor component of cells with plasmacytic features, for example, eccentric nuclei and perinuclear halo.


Images from the initial abdominal ultrasound (A) Jejunal ulcerations with gas inclusions (red arrows).


Images from the initial abdominal ultrasound (B) Enlarged jejunal lymph node with gas (red arrows).


Endoscopy (C,D) Colonic mucosa showing marked generalized hyperemia with small (~1 cm diameter) and diffuse colonic circular erosions.


Endoscopy (E) Ileum mucosa with hyperemia and striations.


Timeline of the dog's clinical course and treatments. Serum albumin values are depicted in the orange line; the reference interval indicated by the faint orange background. The dog's body weight is depicted in the blue line. Pink stars indicate cobalamin injections. Details about the products and dosages can be found in the main text.


Histopathology of the colonic pinch biopsies. H&E (20x) with intact crypts ,overlying fibrino-suppurative exudate.


Histopathology of the colonic pinch biopsies. Areas of complete effacement of normal architecture. With inflammation and marked fibroplasia and neovascularization.


Histopathology of the colonic pinch biopsies. (C) PAS (20x) with no PAS positive macrophages.


Histopathology of the colonic pinch biopsies. (D) PAS (40x) stained colon from a dog with E. Coli-associated GC with PAS positive macrophages for comparative purposes.


Hemispherical nodule in the subungual region of the right great toe.


Fine needle aspiration smear showing benign plump oval to spindle-shaped cells in groups, sheets and cohesive clusters in a background of myxoid material and insert showing the histopathological section, confirming the cytological findings (Pap, x400).


The computed tomography scan with intravenous contrast revealed a large mass in right nasal cavity with destruction of pterygoid plates, the body and the greater wing of the sphenoid, inferior orbital wall and the posterior wall of the maxillary sinus.


The computed tomography scan with intravenous contrast revealed a large hypervascular mass in right nasal cavity with orbital involvement.


MRI showed a hypervascular mass with plenty of flow voids signal, due to containing large vessels, in the right nasal cavity with extension to intracranial and infratemporal spaces.


The angiographic study showed a filling defect in ophthalmic vein according to intraluminal tumor growth.


The excised specimen with an intraluminal extension in to ophthalmic vein (marked in the red box), which was completely excised endoscopically.


Case 1. Preoperative MRI cervical spine T1-weighted with contrast.


Case 1. And T2 weighted There is a large-enhancing expansile mass of the cervical spinal cord extending from the level C1-C7 measuring 9.8 x 1.2 cm. A large tumor cyst extends from end of mass at C7 inferiorly into the thoracic spine.


Case 1. Postoperative sagittal T1-weighted with contrast.


Case 1. T2-weighted. MR images of the cervical spine after laminectomy and posterior fusion. Gross total resection was achieved with no residual tumor.


Case 2. Preoperative sagittal T1-weighted with contrast.


Case 2. T2-weighted. MR images demonstrating a heterogeneous mass within the cervical cord from C1-C7. The superior portion of the mass demonstrates 1.7 x 3.6 cm cystic component.


Case 2. Postoperative sagittal T1-weighted with contrast.


Case 2. T2-weighted. MR images after laminectomy and posterior fusion. Gross total resection was achieved, albeit with marked spinal cord myelomalacia from C2-C3 through C6.


Erythema and swelling around CRT-P insertion site.


TEE revealing vegetation at the anterior leaflet of the mitral valve.


Initial lesion before biopsy. A pedunculated lesion at the right posterior forearm which resembled pyogenic granulomacases.


Scar from previous biopsy. Wide excision with 2 cm peripheral margin and depth until fascia level.


HE staining of lymph nodes. A) Pulmonary hilar lymph node. Note
expansion of extrafollicular areas. Lymph follicles are not abundant and only focally
observed (inset). Scales: 500 mum.


HE staining of lymph nodes. B) Retroperitoneal lymph node as a control. Scales: 500 mum.


HE staining of lymph nodes. Mid-power and . 50 mum
10 mum (D including the inset).


HE staining of lymph nodes. High-power views of the
extrafollicular area of the pulmonary hilar lymph node, showing proliferation of round
cells (plasmablasts). Inset in D) shows small lymphocytes observed in
the paracortex of pulmonary hilar lymph nodes as size controls at the same
magnification.


Scales: 20 mum (A-D).


Immunohistochemistry for round cells (plasmablasts) in the extrafollicular areas of the
pulmonary hilar nodes, labeled by antibodies against A) CD19,. CD20,. Scales: 20 mum (A-D).


IgG,. Scales: 20 mum (A-D).


IgM,. Scales: 20 mum (A-D).


Kappa chain.


Lambda chain. Plasmablasts are
CD19+ CD20- IgG+ IgM-. Sparse
CD20+ cells were judged to be reactive B cells. No monotypia was observed
for kappa and lambda chains.


Multi-labeling immunohistochemistry for phenotypic characterization of plasmablasts in
the pulmonary hilar lymph nodes. A) Chromogenic method. Ki-67+ cells (brown) did not correspond to CD20+ (red) or
CD3+ (green) cells. Scales: 20 mum (A-C). Methods are described in the legends of Supplementary Figure 5.


Multi-labeling immunohistochemistry for phenotypic characterization of plasmablasts in
the pulmonary hilar lymph nodes. ,. Merged figures showing that IgG+ cells
 green), and . Scales: 20 mum (A-C). Methods are described in the legends of Supplementary Figure 5.


Multi-labeling immunohistochemistry for phenotypic characterization of plasmablasts in
the pulmonary hilar lymph nodes.
Immunofluorescence method. VS38c+ cells. Green)
were frequently double-positive for Ki-67 (red). Note that Ki-67 is positive in the
nucleus (located in the center). Round cells in the extrafollicular areas were finally
identified as plasmablasts. Scales: 20 mum (A-C). Methods are described in the legends of Supplementary Figure 5.


(A) Top-10 up-regulated (green color, top) and top-10 down-regulated (red color, bottom) molecular pathways in the patient's tumor.


Line width for each pathway is proportional to the pathway activation level (PAL), scale for PAL values is presented on the right; (B) Gene expression level of Regorafenib targets. Targets included in the "KEGG Pathways in cancer" pathway are highlighted in red.


"KEGG Pathways in cancer" signaling pathway shown as an interacting network. This pathway was hyperactivated in the patient's tumor tissue. Green arrows indicate activation, red arrows-inhibition. Transcript nodes are shown in ovals. The color depth of transcript nodes reflects the extent of node activation (logarithms of the case-to-normal (CNR) expression rate for each node, in which "normal" is a geometric average between expression levels in normal tissue samples). Molecular targets of regorafenib are indicated by black arrows. Visualization was implemented using Oncobox software. The PI3Ks-AKT signaling axis is marked in blue ellipse.


18F-fluoride positron emission tomography/computed tomography bone scan - abnormalities found in the brain parenchyma.


68Ga DOTANOC positron emission tomography/computed tomography - abnormal uptake in brain parenchyma.


Contrast-enhanced computed tomogram(CECT) image (transverse cut) showing tumor in left hypochondrium displacing major vessels.


Histopathology showing pseudo papillary pancreatic epithelium.


The Papanicolaou stain cytology smear slide shows numerous papillary groups of epithelioid cells in a background of lymphoid cells (x100).


The Papanicolaou stain cytology smear slide shows that the epithelioid cells were relatively uniform. The cells had a high nuclear-to-cytoplasmic ratio. The nuclei were predominantly oval and exhibited fine nuclear chromatin. Quite prominent nuclear grooves and irregular nuclear membrane were also noted (x400).


The Papanicolaou stain cytology smear slide shows several psammoma bodies associated with tumor cells (x400).


The tumor cells are immunoreactive with estrogen receptor (x200).


The tumor cells are immunoreactive (nuclear staining) with WT-1 (x200).


Clinical features of the patients. Note the facial profile, dolicocephaly and low-set posteriorly rotated ear.


Clinical features of the patients. ; hypertelorism, low nasal bridge and short philtrum.


Clinical features of the patients. ; short fifth fingers.


A) Computed tomography scan. RA, right atrium; RV, right ventricle; LA, left atrium; LV, left ventricle; asterisk, pericardial effusion.


B) Site of bone marrow biopsy puncture (encircled).


C) Site of ascending aorta stab injury (showed by forceps).


Fluctuant region beneath scalp. Note that there is no discoloration, and the collection does not obey suture lines (a).


Fluctuant region beneath scalp. The arrow indicates the edge of fluid collections, which is migratory depending on patient position (b).


The important diagnosis feature showing subaponeurotic fluid collections crossing above the cranial suture (a).


Ultrasonography revealed mobile hypodense anechoic fluid collections beneath the scalp aponeurosis without the presence of cyst wall and crossed sagittal suture lines (b).


A diagnostic aspirate tap confirmed the presence of serosanguinous subaponeurotic fluid collections.


Transthoracic echocardiography in 4-chamber view showing mass in right atrium (arrows) attached to wall, measuring approximately 5.6 cm x 2.2 cm.


18F-fluoro-deoxyglucose (FDG) contrast enhanced positron emission tomography-computed tomography (PET-CT) images. Transaxial CT, and ,corresponding fused PET-CT.


18F-fluoro-deoxyglucose (FDG) contrast enhanced positron emission tomography-computed tomography (PET-CT) images. Coronal CT and corresponding fused PET-CT sectional images showing non-FDG avid thrombus in right superior pulmonary vein extending upto the left atrium (arrow).


Left nephrostogram showing persistent focal narrowing in the proximal ureter (black arrow) with proximal hydroureteronephrosis. Central pooling of contrast is seen in interpole medulla (white arrow) giving the egg-in-a cup appearance.


X-rays of L4-S1 instrumentation and fusion.


(a) Early phase spinal angiogram of the left T-10 intercostal artery injection, showing filling of the anterior spinal artery and the site of the filum terminale arteriovenous fistulas.


(b) Later phase spinal angiogram showing initial fistulization.


(c) Venous phase of spinal angiogram showing dilated and tortuous draining veins of the malformation.


DynaCT demonstrating serpentine vessel opacification, unable to localize exact fistula site from this study. Lumbar fusion instrumentation (pedicle screws) is visible.


Intraoperative photograph showing the enlarged filum terminale artery connected to the arterialized dilated venous plexus.


Intraoperative photograph showing ligated filum terminale fistula.


Artery and vein penetrating the thick, fibrous dura at the filum terminale with fibrofatty changes (bold arrow). Abrupt transition occurs between the feeding arterial vessel and venous vessel. Filum terminale vein at the center of the image is enlarged and filum terminale artery is distorted (black arrow).


Slit-lamp examination; nasal limbal gelatinous mass with inferior corneal infiltration.


A) One month later, the lesion had decreased.


B) At the third month, CIN had disappeared.


A) Slit-lamp examination: a gelatinous temporal conjunctival mass (7x10 mm) with dilated superficial vessels without corneal involvement is exposed.


B) Abduction limitation in right eye.


Anatomopathological study: moderately differentiated squamous cell carcinoma was confirmed; tumour cells present in corion.


Tumor progression involving ocular globe tissues and soft periorbital structures.


Mediastinal lymphadenopathy in a child with Kawasaki disease:. At presentation.


Eight weeks later.


MRI (T1-weighted with gadoliunium) at presentation in April 2008.


MRI (T1-weighted with gadolinium) at detection of seeded metastasis September 2009.


Clinical appearance of lesion.


Traumatic deep bite interfering with the lesion during occlusion.


Pre-operative scaling.


Occlusal correction.


Full thickness flap elevation facial to tooth 11, 21 using crevicular incision.


Excision of lesion.


Suturing with 3-0 silk suture.


Superficial erosion of bone upon reflection of full thickness flap.


Excised tissue.


Photomicrograph showing features of peripheral ossifying fibroma.


Satisfactory healing seen after 45 days.


Specimen after opening the cyst.


Squamous metaplasia in the cyst.


Solid pseudopapillary neoplasm in pancreatic tail at the time of presentation.


Recurrent mass in the splenic fossa.


Histological features of the recurrent tumor:. Characteristic pseudopapillary architecture observed on microscopy (H&E 100 x.


Lymphovascular invasion by tumor.


Mitotic figures (6 in 10 high-power fields).


Fibrovascular core with discohesive tumor cells.


A diffuse extraoral swelling in the lower one-third of face extending to submandibular region.


Lateral view of the swelling.


Panoramic radiograph showing generalized bone loss.


Posterior-anterior chest radiograph, showing a normal study.


Computed tomography of neck with contrast, axial section demonstrating enlarged lymph nodes without any enhancement or necrosis.


Computed tomography, coronal section demonstrating enlarged lymph node pushing the submandibular gland to one side.


Computed tomography of neck with contrast, sagittal section demonstrating lymph node enlargement at level Ib, II, III and V.


Positron emission tomography/computed tomography images showing fluoro-2-deoxyD-glucose avid supra, and ,infra diaphragmatic lymph nodes, and ,focal fluoro-2-deoxyD-glucose avid in spleen.


Positron emission tomography/computed tomography images after chemotherapy showing complete metabolic and near complete anatomical resolution of supra/infra diaphragmatic lymph nodes and splenic deposits.


(a) Large swelling in the left ankle.


(b) X-ray left ankle revealed expansile osteolytic destruction of the body of talus extending to lower end of tibia and fibula with soft tissue involvement.


A; Widefield Optos imaging of the right eye of a patient with von Hippel-Lindau disease demonstrates a retinal hemangioblastoma in the superotemporal quadrant with associated dilated feeding and draining vessels.


B; Widefield fluorescein angiography of the right eye reveals fluorescein uptake and leakage from the hemangioblastoma with peripheral retinal nonperfusion in the superotemporal quadrant anterior to the tumor.


Optical coherence tomography of the right eye reveals intraretinal fluid extending from the hemangioblastoma towards the temporal macula.


Mucosal colored swelling of approximately 3 cm in diameter on the lingual aspect of mandible on the right side, extending from 32 to 44.


Swelling of approximately 3 cm in diameter on the lingual aspect of mandible on the right side, extending from 32 to 44.


IOPA shows a diffuse radiolucent area with scattered flecks of radiopacities at the apical region of 41-43.


Odontogenic epithelial cells arranged in the form of follicles and stellate reticulum like cells in the center which are surrounded by ectomesenchymal cells (4x).


tall columnar ameloblast like cells on the periphery with stellate reticulum like cells at the center and surrounded by condensed mesenchymal cells (10x).


Neoplastic odontogenic epithelium in the form of large follicles (10x).


Tall columnar ameloblasts like cells showing nuclear palisading, reversal of polarity and stellate reticulum like cells (40x).


Dense ectomesenchymal cells present in the connective tissue stroma (40x).


large masses of dysplastic dentin arranged in a haphazard pattern. (10x).


Irregular masses of dysplastic dentin, areas of calcification and stromal connective tissue(10x).


Cervical computed tomography scan in axial view displaying a right cervical mass of 27.5x17.5 mm. P denotes posterior, L denotes left.


Orbital magnetic resonance imaging in the left eye shows a circumscribed lesion in suprachoroidal space (a).


High hypercaptation of lesion under gadolinium contrast (b).


Circular genome diagrams of the patient. The outer circle (outside the green circle) represents the structure and scale of the chromosome. The middle circle indicates the somatic variation, in which, its Y-axis represents the allelic fraction (AF) value of each locus. 0 is the minimum and 1 is the maximum. The inner circle represents copy number variation (CNV). Orange color indicates deletion; green color indicates amplification, and blue color indicates neutral.


Clinical course of the case.


Chest roentgenogram shows bilateral diffuse micronodular opacities.


Histopathology shows malignant glands and papillary structures with psammoma bodies and cells with classic papillary thyroid carcinoma nuclear features (H&E, 400x magnification).


TTF1 immunohistochemistry labels the neoplastic cells (400x magnification).


(a) Left leg with multiple subcutaneous swellings and few ulcerated nodules.


(b) Axial computed tomography: Homogeneously enhancing relatively hypodense left suprarenal mass with loss of fat plane in anterior pararenal space.


(c) Axial computed tomography: Heterogeneously enhancing left inguinal lymph nodal mass.


Preoperative view of the lesion.


Intraoral periapical radiograph.


Preoperative orthopantogram.


Chest radiograph with no evidence of secondary malignancy.


Postoperative view Figure.


Postoperative orthopantogram.


Clinical photograph of I. O lesions.


Orthopantomogram of the patient showing patchy radiolucency with irregular margins in the left anterior region extending as poorly defined radiolucency into the body of mandible region.


H & E stained sections in x5 magnification showing diffuse presence of round cells in deep connective tissue.


H & E stained sections in x10 magnification showing diffuse presence of two different morphologies of cell populations in deep connective tissue.


H & E stained sections in x40 magnification showing diffuse presence of two different morphologies of cell populations in deep connective tissue.


Cytokeratin-high molecular weight negative staining of the tissue cells.


Cytokeratin 7 negative staining of the tissue cells.


P63 mild positivity of tumor tissue cells.


(a): Panoramic view of haematoxylin and eosin (H&E) stained sections of cystectomy specimen showing a highly infiltrative neoplasm through the vesical muscular wall (40x).


(b): H&E high power view analysis of cystectomy (200x) with invasive carcinoma in muscular propria and intratumoral lymphocyte infiltration.


(c): H&E analysis of metastatic lymph node with carcinoma (200x).


(d): IHC with strong and diffuse positivity for PD-L1 22C3.


Wright-stained bronchoalveolar lavage fluid smears. . Notes: (A-D) Arrows indicate extracellular "tachyzoites", also known as "trophozoites", which can be propagated within the nucleated cells. No intracellular parasites are present. Magnification x1,000.


Macroscopic tumour: an 8 cm tumour with a myometrial infiltration of more than 50%, reaching the uterine serosa B).


E 20x: Solid tumoural nests are observed, consisting of small cells with limited cytoplasm.


The main milestones of the proband's medical history. Reconstructed by the patient's reports and medical records.


The endomyocardial biopsy of the right ventricle (10-50 micron scale). Hematoxylin eosin staining showed: the endocardium is thin. Cardiomyocytes with foci of enlightenment in the perinuclear zone, disarray, with homogenization of the cytoplasm. In individual cardiomyocytes, there are foci of myolysis with the formation of voids in the cytoplasm. Microvessels with red blood cell sludge phenomenon, sclerosed walls, proliferation of endothelial cells, stenosis of the lumen and single perivascular lymphohistiocytic cells. There are minor hemorrhages, mild sclerosis. Staining of congo red (in non-polarized and polarized light), Perls reaction, the PAS reaction are a negative.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. Brain computed tomography (CT) scan without contrast.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. CT scan with contrast.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. Axial T2 weighted.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. Axial T1 weighted without contrast.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. Postcontrast axial T1 weighted.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. MR angiography. Double arrow: associated venous anomaly, arrow: sinusoid pools in the site of the lesion in the right CPA, asterisk: small intraparenchymal hematoma in the site of VP shunt insertion.


Intraoperative views showing:. The gross appearance of the extra-axial lesion in the cerebellopontine angle.


Dissection of the trigeminal nerve, and ,the facial/vestibule-cochlear complex.


Dissection of the lower cranial nerves and posterior inferior cerebellar artery.


(d) Early postoperative brain magnetic resonance imaging showing total resection of the lesion. 5: Trigeminal nerve, 7/8: Facial/vestibulocochlear complex, LCN: Lower cranial nerves, PICA: Posterior inferior cerebellar artery.


Tanycytic ependymoma. (a) T2-axial MRI showing a hyperintense lesion in the left CPA with extension into the internal auditory canal.


Tanycytic ependymoma. The same lesion in axial.


Tanycytic ependymoma. Coronal. Views on T1-weighted MRIs. Postgadolinium enhancement showing a homogenously enhancing lesion extending from the ICA into the left CPA. There are clear mass effect shown on the brainstem and absence of hydrocephalus.


Dynamic computed tomography of the spleen. A gradually enhancing mass (65 x 65 x 55 mm) is observed in the spleen (arrow). No radial visualization of the inside of the tumor is observed. A; Simple phase.


Dynamic computed tomography of the spleen. A gradually enhancing mass (65 x 65 x 55 mm) is observed in the spleen (arrow). No radial visualization of the inside of the tumor is observed. B; Arterial phase.


Dynamic computed tomography of the spleen. A gradually enhancing mass (65 x 65 x 55 mm) is observed in the spleen (arrow). No radial visualization of the inside of the tumor is observed. C; Portal vein phase.


Dynamic computed tomography of the spleen. A gradually enhancing mass (65 x 65 x 55 mm) is observed in the spleen (arrow). No radial visualization of the inside of the tumor is observed. D; Equilibrium phase.


Chest X-ray showing massive left side pleural effusion and right upper zone nodular opacity (small air pocket in left apex is due to previous aspiration).


Cytological examination of the pleural fluid showing numerous atypical plasma cells with binucleate forms and plasmablasts.


(a) Computed tomography scan of the chest with contrast showing bilateral effusion with pleural infiltration, right upper lobe involvement, soft tissue lesion in the posterior mediastinum.


(b) Computed tomography scan of the abdomen showing lytic lesions in pelvis and sacrum.


Bone marrow biopsy showing extensive replacement of marrow by sheets of atypical plasma cells, with binucleate and plasmablasts.


Preoperative imaging (a) coronal T2-weighted magnetic resonance imaging (MRI) shows a hyperintense mass measuring 2.4 x 2.6 x 1.9 cm in the sellar and suprasellar region.


(b) Coronal T1-weighted MRI shows a hyperintense mass with a hypointense, nonenhancing nodule.


Postcontrast T1-weighted MRI in the axial.


Sagittal. Planes shows a heterogeneously enhancing mass.


Preoperative imaging noncontrast computed tomography image in sagittal.


Axial. Planes shows a sellar mass extending into the suprasellar region. No calcifications are seen in the lesion.


Intraoperative imaging intraoperative images of tumor texture and behavior, including. Motor oil drainage.


Thick, fibrous cystic capsule.


Cholesterol granuloma.


Adhesion to the optic chiasm.


Postoperative imaging postcontrast axial T1-weighted image in sagittal.


Coronal. Planes shows gross total resection of the tumor with decompression of the optic chiasm. The residual fat graft is noted in the inferior portion of the resection cavity (yellow star). The orange arrow in Figure 4a shows the placement of the Medpor graft, and the green arrow points to the layering of the pedicled nasoseptal flap for a multilayered closure.


Beta-catenin stain beta-catenin immunostaining at x100 demonstrating dense fibrous walled cyst with squamous cells.


Panoramic radiograph showing well defined periradicular radiolucency.


Axial T1-weighted image shows hypointense, lobulated contour lesion (arrow) within the confluens sinuum.


Axial T2-weighted image demonstrates lesion is hyperintense relative to brain parenchyma.


Sagittal T2-weighted image indicates hyperintense lesion (arrow) extending from confluens sinuum through the superior sagittal sinus and scallop-shaped area of erosion in the neighboring bone.


Sagittal magnetic resonance venography maximum intensity projection image revealing obvious venous flow, which divided into 2 channels around filling defect (arachnoid granulation), and joined distally.


External clinical photograph. Cystic mass in the upper lip.


Fine-needle aspiration cytology showing many anucleated squames and few benign nucleated squamous cells in a dirty background (May-Grunwald-Giemsa, x100).


Magnetic resonance imaging T2.


Sagittal view.


Axial view. Coronal view. It evidence lesion type C T8-T9.


Computer tomography Scan.


Medical image.


Infected surgical wound. Placement of negative pressure treatment.


Radiography of thoracic spine.


Radiography of thoracic spine. Anterior - Posterior view. Lateral view. It observe correct placement of pedicle screws without signs of misplacement or vertebral lysis.


X-ray skull was normal showing no bony lesion or lytic lesion. Inset (upper left) demonstrates the occipital swelling of the case.


Cytological smear showing cohesive clusters and scattered single meningothelial cells having indistinct cytoplasmic borders, round to oval nuclei and inconspicuous nucleoli. Inset (lower left) exhibits a psammomatous calcification. (Leishman-Giemsa, x400).


Section showing immunostaining positivity for epithelial membrane antigen in meningothelial cells (x100).


Lesion at presentation as erythematous friable papule, measuring 1 cm in diameter, on the right half of the lower lip.


5 days after suture removal of the partially excised lesion when a two cycles of cryotherapy was done.


After one week of topical salt use, the lesion was markedly reduced in size and became a small papule.


Complete resolution of the lesion after two weeks of topical salt.


Timeline of the clinical course.


Skull film, lateral projection showed a rounded osteolytic lesion with a nonsclerotic rim in the left parietal bone.


Lesion manifested as a mass in hard palate.


CT scan of the lower abdomen.


Leptomeningeal enhancement involving brain and cervical spinal cord.


Ill defined granuloma with multinucleated giant cells (arrow) and bone fragments, HE staining, 4x.


(a) A dome-shaped pearly white nodule on the right areola adjacent to the nipple. (b) Photomicrograph showing a cyst lined with stratified squamous epithelium and the lumen was filled with keratinous material (H and E, x40).


(a) A well-defined, pearly white nodule on the right nipple. (b) Photomicrograph revealed that the cyst wall was lined with stratified squamous epithelium and its lumen filled with keratinous material (H and E, x40).


Orthopantomogram of the patient; asterix indicates the extent and nature of the radioluceny in between the apices of the right maxillary canine and lateral incisor. Inset shows the periapical radiograph of the area.


The lesional area after raising the semilunar flap. Note the shape of the lesion and bone overlying the cyst.


Total removal of the cystic content in toto.


Timeline.


(A) One of the two smaller trichilemmal cysts (TCs).


(B) Proliferating trichilemmal cyst (PTC) peroperative.


(C) PTC with an ulcerating center.


(D) Defect after removal of PTC.


(E) Closure with local fasciomusculocutaneous flaps.


(F) Small wound 6 months after primary closure.


(A) One of the two smaller TCs.


(B) PTC axial view.


(C) PTC coronal view.


(D,E) Macroscopy of the PTC.


(F) Macroscopic view of sliced PTC.


(G) Microscopy of PTC, depicting surface epithelia and a tumor process.


(H) Microscopy depicting the compact keratin and calcifications.


(I) Microscopy with squamous epithelial cells without a granular cell layer.


Preoperative axial noncontrast computed tomography image shows a heterogeneous intraventricular mass predominantly isodense to grey matter, with a right posterior hypodense component. There is left greater than right lateral ventricular hydrocephalus.


(a) Axial T2-weighted magnetic resonance imaging (MRI) shows a heterogeneous intraventricular lesion containing T2-hypointense components anteriorly and a cystic component at the right posterior aspect.


Postcontrast axial.


Coronal.


Sagittal. T1-weighted MRI sequences show a heterogeneously enhancing mass following intravenous contrast. The sagittal image also shows extension of the posterosuperior extent of the lesion in the undersurface of the posterior body of the corpus callosum.


Postoperative imaging. (a) Postcontrast axial T1-weighted image shows resolution of hydrocephalus with a small residual intraventricular enhancing mass consistent with sub-total resection.


Postoperative imaging. (b) Axial noncontrast head computed tomography scan shows postoperative pneumocephalus with residual tumor better seen on magnetic resonance imaging. A partially visualized shunt traversing the body of the left lateral ventricle is seen with resolution of previous hydrocephalus.


Postoperative imaging. (c) 6-month postcontrast axial T1-weighted image shows stable lesion with minimal enhancement.


Hyalinized vessels in glial component.


Vague neurocytic rosettes: ring-like arrangement of neurocytic tumor cells around eosinophilic core.


Ct-scan showing the invaginated tract containing a 24 mm mass.


H&E, 100x magnification: Ileal submucosal spindle cell proliferation.


H&E, 200x: hypercellular proliferation composed of spindle cells with nuclear atypia and intermingled moderate amount of inflammatory cells.


MDM2, 20x: immunohistochemistry against MDM2-antibody shows diffuse and intense nuclear reaction.


Incision of the right corpus cavernosum contributed to drainage of a large amount of pus.


(a) With repeated hemoptysis, investigation with high resolution computed tomography after a month (selected axial image) showed the left upper lobe mass is significantly enlarged (arrow).


(b) Selected coronal image of high resolution computed tomography could appreciate the ground glass halo around the enlarged lung mass (arrow).


A-C. Coronal CT reconstruction in early venous phase after i. V. Contrast application, depicting primary tumor and vascular extent.


Ultrasound images in Doppler mode highlighting hepatoatrial transition. As well as atrial dilation and movement of the sacciforme intravascular tumor extension over the tricuspid valve into the right cardiac ventricle All depicted images represent the initial diagnosis.


A. Intravascular tumor extensions along centimeter scale: * subhepatic VCI; ** intrahepatic VCI; *** intracardiac.


B. Dissected kidney along centimeter scale.


Clinical picture showing exophytic growth on lingual surface of mandibular lower left canine.


A photo micrograph showing variably sized blood vessel which were lined by plump endothelial cells.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. Non-contrast head CT image demonstrated a densely calcified mass (arrow) in the left temporal lobe.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (a) Brain MRI T2/FLAIR image revealed a hypointense lesion (arrow) in the left temporal lobe.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (b) Brain MRI T1-weighted image showed corresponding heterogeneous hypointense signal (arrow).


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (c) Brain MRI post-contrast T1-weighted image further demonstrated irregular enhancement (arrow) in close association with the left middle cerebral artery.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. Hematoxylin and eosin stained tissue sample demonstrated. Innumerable.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. Confluent psammoma bodies (blue arrows) intimately associated with.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. Extensive fibrotic bundles (red asterisks) as well as. Perivascular proliferation of spindle cells (green arrows), which are characteristic findings of meningioangiomatosis.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (a) Brain MRI T2 image revealed a CSF-filled hyperintense resection cavity (arrow) in the anterior left temporal lobe.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (b) Brain MRI post-contrast T1-weighted image demonstrated irregular residual enhancement (arrow) intercalated with the middle cerebral artery consistent with residual disease.


Ultrasonographic and radiographic findings. (a) A relatively well-demarcated, lobulated, hypoechoic mass with mild heterogeneous echogenicity is noted, showing a focal, ill-defined border, suggesting the possibility of malignancy.


Ultrasonographic and radiographic findings. (b) Positron emission tomography-computed tomography revealing focal fluorodeoxyglucose uptake in the same lesion.


Abdominal magnetic resonance imaging. T2 sequences show a small nodular mass (arrow) with a hypointense signal at the level of the major duodenal ampulla, measuring approximately 10.2 mm in its largest axis.


Abdominal magnetic resonance imaging. Pancreas divisum diagnosis, arrow 1 shows the ventral pancreatic duct, arrow 2 shows the dorsal pancreatic duct, and between those, the arrow 3 shows the common bile duct.


Macroscopy specimens of pylorus-preserving pancreaticoduodenectomy. Pancreas divisum, arrow 1 shows the dorsal duct with a vegetative lesion (17.0 x 2.0 mm) extending to the major ampulla (star), arrow 2 shows the ventral duct, and ,the arrowhead shows a poorly defined densification area near the minor ampulla (5.0 mm).


Macroscopy specimens of pylorus-preserving pancreaticoduodenectomy. Duodenal wall mass (12.0 mm).


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. The poorly-differentiated adenocarcinoma of the major ampulla H&E. And CK7 IHC staining.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. The well-differentiated neuroendocrine tumor of the minor ampulla H&E.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. And synaptophysin IHC staining.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. Spindle cells in the gastrointestinal stromal tumor H&E.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. And DOG1 IHC staining. The histological sections stained are presented at x100 magnification and the right small squares represent x40 magnification.


Transversal CT scan. The yellow arrow indicates bowel in the obturator foramen.


Coronary CT scan. The yellow arrow indicates bowel in the obturator foramen.


Intraoperative finding. A segment of the small bowel was trapped in the obturator canal.


Laparoscopic management of the obturator hernia using an endoloop.


Intraoperative real-time ICG fluorescence angiography following bowel reduction. The left upper image demonstrates the laparoscopic mode; the middle image indicates the angiographic mode while the lower image indicates the fluorescence mode (corresponding to the enlarged image). Note the longitudinal discolouration in the middle of the anti-mesenteric bowel surface with lack of perfusion.


Real-Time ICG fluorescence image following anastomosis showing a well perfused anastomosis.


Cells arranged in 3D clusters. MGG.


40X) Microfilaria. MGG,40X).


Grey white to grey brown solid and cystic mass with multiloculated cystic cavities being filled with mucoid material and serous fluid.


Axial T1-weighted magnetic resonance images without.


With. Gadolinium demonstrating a 7-cm homogeneously enhancing left neck mass circumferentially encasing the left internal carotid artery, extending from C2 to C4.


Sagittal.


Axial. T2-weighted magnetic resonance images, again showing the left neck mass encasing the left internal carotid artery.


Mid-to-late arterial phase of a left common carotid artery injection before.


After coil embolization. Of the common, internal, and external carotid showing reduced vascularity of the mass.


(a) Hematoxylin and eosin (H and E) stain at low-power magnification (x40) demonstrating lymph node hyperplasia with vascular proliferation magnification.


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Front view shows the swelling extending from the right ramus (arrow black outline) crossing the midline up to the left parasymphysis region (solid black arrow) of the mandible.