Coronal preoperative MRI in patient 2 revealing pancreas divisum with a cyst lesion measuring 7.3 cm involving the uncinate process and duct of Wirsung. Of note, mural nodularity is appreciated.


(A) Liver metastases detected using magnetic resonance imaging (MRI) in November 2019.


(B) Response of liver metastases detected using MRI in January 2020 after treatment with etoposide combined with cisplatin and continued ADT plus pembrolizumab. Metastases are indicated by red arrows.


(C) Clivus and adjacent right sphenoid bone metastases detected by MRI in April 2020.


(D) Meningeal clivus and adjacent right sphenoid metastases in November 2020. Metastases are indicated by red arrows.


The altered landscape and phylogenetic reconstruction of the two samples. (A) The second panel shows the cancer cell fraction estimated by using PyClone and calculated using the read depth of mutations, copy numbers, and purity of tumors. Other panels are showing the frequency of mutations in three types of prostate cancer using public data from the cBioPortal (1400 primary tumors, 54 NEPC samples, and 880 mCRPC samples). Important functional cancer genes are marked in red.


The altered landscape and phylogenetic reconstruction of the two samples. (B) Overview of copy number alterations and cancer genes encompassed in segments are shown in red.


The altered landscape and phylogenetic reconstruction of the two samples. (C, D) Fishplot indicating the dynamic clonal progression of the tumor, and clonal evolution tree showing the phylogenetic relationship between the two samples.


Selected sagittal.


Axial.


Coronal. Slices of CT, PET, and ,fusion images.


MIP image. Of PET-CT showing increased focal FDG uptake in the subcutaneous fatty tissue posterior to the proximal gluteal muscle planes at right thigh.


Typical vimentin positivity in the renal cell carcinoma cells (Vimentin Antibody, x100).


Malignant clear cell infiltration in the fibroadipose tissues, with vascular tumor embolus adjacent to the tumor (Hematoxylen and eosin, x40).


MIP image. Of PET-CT showing increased focal FDG uptake at the posteromedial part of proximal third of right cruris.


MRI shows a soft tissue lesion in the intermuscular area, with a diameter of 2.5 cm, which is hypointense on T1-weighted images.


Hyperintense on T2-weighted images. And showing intense contrast enhancement.


Fine-needle aspiration, left leg, Diff-Quik (x200), showing a cellular yield of cohesive, three-dimensional tumor clusters with cellular overlapping and architectural disorder.


Fine-needle aspiration, left leg, Diff-Quik (x400), columnar tumor cells arranged in glandular configuration with elongated nuclei, mild to moderate nuclear pleomorphism, and finely dispersed chromatin.


Contrast-enhanced CT imaging demonstrating no cirrhotic changes prior to 90Y administration.


Generalized mottled changes compatible with postembolization edema 3 months after 90Y administration.


The patient subsequently developed a large, nonenhancing, complex cystic central hepatic lesion suggestive of a post-90Y biloma 14 months after administration.


Over the subsequent 45 months developed a progressively irregular texture suggestive of hepatic cirrhosis.


Needle core biopsy of the liver taken 47 months after 90Y administration. A; There is a large band of chronically inflamed fibrous tissue, highly suggestive of cirrhosis. HE. X10.


Needle core biopsy of the liver taken 47 months after 90Y administration. B; This is highlighted by Masson trichrome staining, demonstrating chronically inflamed fibrous tissue (blue), highly suggestive of cirrhosis.


Needle core biopsy of the liver taken 47 months after 90Y administration. X10. C; The nonfibrotic liver showed macrovesicular steatosis with mildly active steatohepatitis. HE. X40.


Needle core biopsy of the liver taken 47 months after 90Y administration. D; On the other hand, sinusoidal Kupffer cells showed a mild degree of hemosiderosis. Perls iron stain. X40.


(A) Intraoral view of the upper right quadrant at baseline; calculus and gum bleeding is visible.


(B) Intraoral view of the frontal lower teeth at baseline; small amounts of calculus and pus discharge are visible.


Panoramic radiograph at baseline.


(A) Upper right quadrant after antibiotic therapy.


(B) Frontal lower teeth after antibiotic therapy.


Intraoral view of the frontal lower teeth 14 days after SRP and splinting.


Intraoral view 6 months after SRP.


Panoramic radiograph 6 months after SRP: tooth #43 showed an extensive periapical lesion with well-defined borders and bone loss extruding onto the root's mesial surface.


Walking" probing of the periodontal pocket using a Naber periodontal probe. Distal buccal point.


Walking" probing of the periodontal pocket using a Naber periodontal probe. Middle buccal point.


Walking" probing of the periodontal pocket using a Naber periodontal probe. Mesial buccal point , all measurements are 2 mm probing depth.


Walking" probing of the periodontal pocket using a Naber periodontal probe. (D) Narrow and deep 8 mm periodontal pocket on the mesial tooth surface.


(A) No bleeding was observed immediately after endodontic access opening.


(B) Instrumentation of the root canal using an iRace rotary endodontic instrument.


(C) Passive ultrasound irrigation with an ultrasound tip.


(D) Treating the root canal with ozone gas.


(A) Working length confirmation.


(B) Immediately after obturation.


(C) Six-month follow-up showing complete healing of the bone defect in the periapical area and interdental septum.


Prozone ozone generator.


GTG-banding revealed a complex karyotype multiple numerical and or structural rearrangements.


Pathology of Solid Pseudo-Papillary Tumor of the Pancreas.


A preoperative photograph revealed total hairy scalp and forehead avulsion with only a connection in the nuchal area.


The intraoperative and postoperative indocyanine green angiography (ICGA) mapping results. A; Intraoperative ICGA mapping with SPY-Q analysis of perfusion in the replanted scalp. Asterisk represents the left temporal area that is automatically selected as a reference with a 100% perfusion value. Areas with 25% perfusion relative to the maximal perfusion reference were traced with blue lines. Areas confined by the blue lines represent well-perfused tissue with more than 25% of the reference area perfusion.


The intraoperative and postoperative indocyanine green angiography (ICGA) mapping results. B; The color reversal version of ICGA image when the necrotic area became mature. Please note the hypoperfused frontoparietal area represented by the color white.


All skin grafts survived with acceptable cosmetic results at the 1-month follow-up.


Periodic acid Schiff (PAS) stain, 400x magnification, shows an enlarged glomerulus with deposits which are PAS negative and occasional PAS positive hyaline caps. Tubules and interstitium are normal.


Silver stain, 400x view shows deposits are silver negative.


Deposits were not congophilic.


Immuno-fluorescence stain: the deposits were negative for all IgG, IgM and complements.


Electron microscopic study of renal biopsy specimen fixed using gluteraldehyde, viewed under 40,000x magnification revealed abundant subendothelial deposits of large fibers (97nm in width) with long spacing striations suggestive of collagen fibers; confirming the diagnosis of collagenous glomerulopathy.


Kidney biopsy slide stained with hemotoxylin-eosin stain and periodic acid Schiff stain (PAS), viewed under 400x magnification shows an enlarged glomerulus with increased mesangial matrix and mesangial interposition with diffuse membrane thickening. Tubules and interstitium are normal.


Magnetic resonance imaging (MRI) showing a T1 T2 hypointense lesion in the right supraclavicular region which is diffusely infiltrating the adjacent soft tissue.


Contrast-enhanced CT of chest showing pericardial effusion (white arrow), bilateral pleural effusions and left-sided lung consolidation (red arrow).


Magnetic resonance imaging with diffusion sequence shows an important restriction of diffusion in the peripheral region.


Hematoxylin-eosin stain showing both tumor components and transition area (x2).


Average percentage of MGMT methylation.


Initial clinical presentation:clinical composite photograph of the patient's left eye reveals an extensive fleshy salmon solid tumor of the conjunctiva extending into the orbit inferonasally.


Histopathology from biopsied conjunctival lesion:photomicrograph reveals sheets of large neoplastic lymphoid cells with moderate nuclear pleomorphism, vesicular chromatin, and large nucleoli underlying normal epithelium. (H&E, 30X).


Immunohistochemical stains of conjunctival lesion:photomicrographs of multiple immunohistochemical assays showed that the large lymphoid cells stained strongly positive for CD20 and MUM-1; it was also positive for Pax-5 and weakly positive for Bcl-6. The large lymphoid cells were negative for CD10. The small background lymphocytes stained positive with CD3.


Patient's lesions.


Computed tomography scan (axial section) of thorax showing a large heterogeneously enhancing soft tissue mass lesion in the right perihilar region involving right lower lobe extending into the mediastinum with loss of fat planes with esophagus, aorta, and right crus of the diaphragm. There is no chest wall or pleural involvement.


Immunohistochemistry picture from lung lesion showing tumor cells positive for neuron specific enolase (x200).


Chest X-ray demonstrating multiple lung metastases of sarcoma and a metastasis to the right pleura and left hemopneumothorax.


Chest X-ray demonstrating multiple lung metastases of sarcoma and bilateral pneumothorax.


A pair of neoplastic cells (upper left) shows scant cytoplasm, irregular nuclear contours, visible small nucleoli, and a possible inter-cellular 'window'. The cytoplasmic eosinophilia of the neoplastic cells contrast with the cytoplasmic basophilia of the larger reactive mesothelial cell (lower right) (Wright stain, x1000).


Cellular smear showing branching papillary fronds (Pap, x100).


Cells have round to oval nuclei with fine granular chromatin and have nuclear grooves (Pap, x400).


Facial features and limb malformations of the fetus in case 1. A 28-year-old Chinese woman was referred for prenatal diagnosis at 16 weeks of gestation due to fetal nuchal translucency (NT) thickening (A).


Facial features and limb malformations of the fetus in case 1. The pregnancy was terminated at 20 weeks, and autopsy showed distinct facial features . Limb defects.


Facial features and limb malformations of the fetus in case 1. The pregnancy was terminated at 20 weeks, and autopsy showed distinct facial features.


Facial features and limb malformations of the fetus in case 1. Limb defects.


Facial features and limb malformations of the fetus in case 1. . In the fetus as indicated by the arrows.


Clinical features of the proband and Sanger sequencing results in case 3. The proband.


Clinical features of the proband and Sanger sequencing results in case 3. II: 1) presented with typical facial features of Cornelia de Lange syndrome (CdLS) and upper limber defects.


Clinical features of the proband and Sanger sequencing results in case 3. The (F) panel shows the Sanger sequencing results of NIPBL c.448dupA mutation in the family.


Typical complex-branching pseudopapillary structures surrounded with single and/or loosely cohesive neoplastic cells (PAP, smear).


The clear vacuoles were often single but numerous clear vacuoles were also observed both in neoplastic groups and single, discohesive, plasmocytoid neoplastic cells (Diff-Quik, smears).


Small groups of cells with clear cell vacuoles in variable sized (Diff-Quik, smear).


Intracytoplasmic vacuoles are well defined like coin-shaped (Diff-Quik, smears).


Vacuoles can be seen often and easily in Diff-Quik stained smears (Diff-Quik, smears).


Neoplastic cells shows nuclear immuno reactivity with beta-catenin (cell block).


Strong cytoplasmic immuno reactivity with vimentin antibody (cell block).


CD10 also showed strong cytoplasmic immuno reactivity similar to vimentin (cell block).


ctDNA SMSEQ analysis of CSF. Blue box, expected ERBB2 (HER2) gene counts; black dot, ERBB2 gene counts (HER2 amplification) in the patient's CSF.


(d-f) Represent coronal computed tomography, positron emission tomography, and fused positron emission tomography/computed tomography images, respectively.


Histopathology of the lesion showing areas of laminated keratin with no foci of calcification or hemorrhage, confirming benign epidermoid cyst.


The gamma spectrum measurement of the contamination demonstrates an energy peak in 500-550 keV region (due to positron formation at 511 keV). The rectangular bar shows the energy window used for Co-57 marker in the superimposed image (Figure 3 on the right).


The top row (A1-G1) displays magnetic resonance (MR) images from the initial study during the first admission, and the bottom row (A2-G2) displays the corresponding images during the relapse 2 months later. The lesion (A1,A2) returns an isointense signal on T1-weighted images and (B1,B2) demonstrates enhancement on post-contrast images. (C2) High T2-signal cystic lesions are seen along the leptomeningeal surface that increased in size and number during the relapse. (D2) The internal signal of these cystic lesions is not entirely suppressed on fluid attenuation inversion recovery (FLAIR) sequence. (E1,E2) No blooming artifacts seen on gradient echo (GRE) sequence. (F1,G1;F2,G2) Restricted diffusion is not demonstrated in both studies.


The top row (A1-C1) displays MR images from the initial study during the first admission, and the bottom row (A2-C2) displays the corresponding images during the relapse 2 months later. (A1,A2) There were cystic lesions with high T2 signal along the leptomeningeal surface. These initially small non-enhancing cystic lesions [white arrows, (B1)] increased in size and number in the follow-up scan [white arrows, (B2)]. (A2) Brain tissue was seen herniating through a Burr hole from a previous external ventricular shunt site, indicating that there was increased intracranial pressure. (C1,C2) Coronal post-contrast T1 images demonstrate the predominantly basal cisternal location of the nodular leptomeningeal thickening.


MR spectroscopy (TE/TR = 144 ms/2,000 ms) findings of elevated choline:creatine ratio (4.34) suggesting high cell turnover in favor of malignancy. The absence of a singlet peak at 3.8 ppm makes tuberculoma less likely.


ML phylogeny of the O. anthropi 16S sequences deposited in GenBank. The results revealed that our 16S sequence 16S_B1 has the closest phylogenetic relationship with O. anthropi.


Preoperative clinical photographs showing intraoral swellings in the retromolar area on right side.


Preoperative clinical photographs showing intraoral swellings in the retromolar area on left side.


CT image showing bilateral expansile radiolucent lesion surrounding both the mandibular and maxillary third molar regions along with supernumerary teeth.


CT image shows maxillary radiolucent lesion surrounding the right impacted third molar.


CT image shows maxillary radiolucent lesion surrounding the left impacted third molar.


The coronal view of mandible in CT image shows bilateral lingual bone perforation.


Cystic fluid aspirate shows straw-colored fluid.


Histopathological section showing the cystic epithelial lining typically of dentigerous cyst.


Another histopathological section showing the cystic epithelial lining typically of dentigerous cyst.


Intraoperative clinical photograph showing resultant bony cavities after enucleation of dentigerous cysts in mandible.


Postoperative clinical photograph showing the gauze packed in to the bony cavities after cyst enucleation.


Intraoral clinical view after 6 months showing the healing of bony cavities.


Postoperative panoramic view after 5 months of enucleation showing significant amount of bone formation.


Chest CT scan- Axial view: Normal parenchymal lung tissue without evidence of active chest disease or intrathoracic lymphadenopathy.


(a) Abdomen and pelvis CT scan: The liver is large measuring up to 24 cm (blue arrows). The spleen is large measuring 17.4 cm (red arrows), retrocrural lymphadenopathy (white arrows).


(b) Abdomen and pelvis CT scan: Retroperitoneal lymph nodes (white arrows).


Gallium scan: Large region of intense focal uptake midline abdomen compatible with mesenteric (blue arrows) and retroperitoneal lymphadenopathy (white arrows). No abnormal lung uptake is seen.


Lymph node biopsy: (hematoxylin and eosin stain) lymphohistiocytic infiltrate (red arrows).


Lymph node biopsy: Many acid-fast bacilli (blue arrows).


Head MRI findings. There was no tumor in the pituitary gland (white arrow).


18F-FDG PET/CT scan of a 51-year-old Caucasian female with symptoms of central pontine myelinolysis. Scan is showing localized FDG uptake in the pons, with normal and symmetrical activity in the rest of the brain.


MR-scan T2-weighted image showing a hyperintensive region in the central part of pons. In addition, hyperintensive region was present symmetrically in the caput nucleus caudatus, putamen, and the lateral part of thalamus.


Upper image: T2 axial image of the lesion surrounding the catheter (red arrow). The granuloma appears as an extra-axial lesion isodense to the myelon. Lower image: T1 contrast sagittal image showing a space-occupying, ring-enhancing, inhomogeneous, extra-axial mass (red arrow) in the spinal canal at the level of T4.


T2 sagittal image of the same lesion with clearly visible extensive T2 signal changes in the spinal cord. The tip of the catheter is seen encased in the granuloma substance (red arrow).


T1 contrast imaging. Upper image: Axial image showing a large recurrence overshadowing and compressing the spinal cord (pink arrow). Lower image: The recurrent granuloma is seen here as a large, ring-enhancing, inhomogeneous, mass-causing high-grade compression of the spinal cord (pink arrow).


(a-c) Multiple nodulo-papular, ulcerated lesions in gingiva involving the entire mandibular arch, gingiva of left posterior maxillary arch in relation to the premolars and molars along with similar lesions in the posterosuperior aspect of the left buccal mucosa (yellow arrows).


Orthopantomogram showing severe generalized irregular alveolar bone destruction in the entire mandibular and in the left posterior maxillary alveolar ridge region.


(a) The presence of sheet-like proliferation of Langerhans cells, having coffee bean-shaped appearance, eosinophils, and plasma cells (H and E, x100). (b) Langerhans cells exhibiting positivity for anti-CD1a (x40).


Necrosis of the frontal region of the mandibular alveolar ridge and three missing incisors.


Magnetic resonance imaging of the girl's mandible (T1 TSE fat sat contrast medium sequence) showed areas of bone necrosis (star) with peripheral reactive bone contrast enhancement (arrows) and enhancement of the soft tissue edema (arrowheads).


Histopathology of the biopsy specimens taken from the lower jaw (first biopsy). (a) Inflamed gingival mucosa with superficial erosions, with granulation tissue and dystrophic calcifications. Retrospectively, calcifications were "reinterpreted" as remains of destructed alveolar bone. HE, original magnification, x4.


Histopathology of the biopsy specimens taken from the lower jaw (first biopsy). (b) Recanalization of the small vessels in the inflamed gingival mucosa (mark). Note the intense mixed inflammatory infiltrate in the background and the swollen endothelial cells. HE, original magnification, x20.


Total colonoscopy revealed a lesion in the rectum below the peritoneal reflection (4 cm above the anal verge).


A colonic pull-through segment of about 10 cm was left outside the anal canal without any tension and was fixed by sutures under indocyanine green fluorescence imaging.


Final coloanal anastomosis was performed without diverting the stoma under indocyanine green fluorescence imaging.


Diffuse enlargement and ulceration of labial gingiva.


Enlargement and ulceration of palatal mucosa.


Intra oral peri apical radiograph.


Infiltrated placard with alopecia, telangiectasias and squames located on the scalp.


Infiltrated placards with telangiectasias and squames located on the trunk.


Infiltrated plaques with telangiectasias and squames located on the lower limbs.


Diffuse granulomatous panniculitis and dermatitis, mainly comprised of epithelioid histiocytes and multinucleated giant cells, some with vacuolated cytoplasm, others with a large number of nuclei or with bizarre, triangular shapes, punctuated by collections of lymph and plasma cells; HEx40.


IHC: CD3 stains the small lymphocytes spread within the granulomatous infiltrate; x100.


Left picture shows the frontal view of the patient showing microcephaly, prominent nose (wide bridge, broad root, columella under ala nasi), Middle picture shows Oligodontia, Right picture shows the Generalized brachydactyly (A written consent was obtained from the patient's parents to publish this image).


Histological and immunophenotypic results of excisional biopsy of left cervical lymph node. Hematoxylin and eosin (H&E)-stained sections is seen (A).


Histological and immunophenotypic results of excisional biopsy of left cervical lymph node. Immunohistochemical staining of these specimens shows that the infiltrated lymphocytes are positive for CD20.


Histological and immunophenotypic results of excisional biopsy of left cervical lymph node. , CD21.


Histological and immunophenotypic results of excisional biopsy of left cervical lymph node. Of follicular dendritic cells, and EBER (magnification x20).


Histological and immunophenotypic results of excisional biopsy of the axillary lymph node and peripheral blood smear. H&E-stained sections is seen.


Histological and immunophenotypic results of excisional biopsy of the axillary lymph node and peripheral blood smear. Immunohistochemical staining of the specimens shows that the diffuse infiltrated lymphocytes are positive for CD20.


Histological and immunophenotypic results of excisional biopsy of the axillary lymph node and peripheral blood smear. EBER. (magnification x20).


Histological and immunophenotypic results of excisional biopsy of the axillary lymph node and peripheral blood smear. Wright's staining of peripheral blood smear showed typical atypical lymphocytes (D) (magnification x400).


Preoperative CT scans showing a large tumor in the nasopharynx. (A) Head CT image showing dense mass of nasopharyngeal soft tissue, protruding into the cavity, with regular shape and uniform density. The left eustachian tube and pharyngeal orifice are not visible, while the right pharyngeal crypt appears shallow.


Preoperative CT scans showing a large tumor in the nasopharynx. (B) Nasopharyngeal CT scan showing a mass-like shadow on the posterior lateral wall of the left nasopharyngeal roof.


Preoperative CT scans showing a large tumor in the nasopharynx. The enhanced scan image showing uneven density in the arterial phase (C).


Preoperative CT scans showing a large tumor in the nasopharynx. Areas with intense dye uptake in the venous phase, and small patchy low-density shadows (D).


Preoperative CT scans showing a large tumor in the nasopharynx. Postoperative head CT showing that the tumor is completely resected (E).


Microphotographs showing the histopathological features of the tumor. (A) Dense areas with cellular proliferation alternating with hypocellular areas (H&E; x40).


Microphotographs showing the histopathological features of the tumor. (B) Area of the tumor showing disorganized cellular arrangement (H&E; x40).


Microphotographs showing the histopathological features of the tumor. (C) Area with tumor cells arranged in stripes (H&E; x100).


Microphotographs showing the histopathological features of the tumor. (D) Area with tumor cells arranged in storiform pattern (H&E; x100).


Microphotographs showing the histopathological features of the tumor. (E) Multinucleated giant cells deposited in a myxoid stroma (H&E; x100).


Microphotographs showing the histopathological features of the tumor. (F) Multinucleated giant cells deposited in a hyaline stroma (H&E; x200).


Microphotographs showing the histopathological features of the tumor. (G) Interstitial vessels with hyaline degeneration (H&E; x100).


Microphotographs showing the histopathological features of the tumor. (H) Hypercellular areas showing fusiform or oval cells, with no apparent atypia, few cytoplasm, large and deep stained nuclei, and oval nuclei as well as some vacuolated nuclei and some tumor cells with nucleoli. Mitotic figures were 2 per 50 high-power fields (H&E; x400).


Microphotographs showing the histopathological features of the tumor. (I) Multinucleated giant cells varying in size and shape showing nuclei nested in the cytoplasm in a wreath-like and lobulated-shape (H&E; x400).


Micrographs showing characteristics of tumor stroma (A) Area showing tumor cells arranged in a wavy pattern (H&E; x40).


(B) Area showing apparent myxoid degeneration in the stroma (H&E; x40).


(C) Multinucleated giant cells with deep nuclear stains within the pseudovascular space (H&E; x200).


(D) Multinucleated giant cells distributed among the spindle tumor cells and the collagenous stroma (H&E; x200).


Immunohistochemical analysis of the tumor. (A) IHC image showing cells with diffuse CD34 positivity (original magnification x200).


Immunohistochemical analysis of the tumor. (B) IHC staining for BCL-2 showing diffuse membrane and cytoplasm positivity (original magnification x200).


Immunohistochemical analysis of the tumor. (C) Tumor cells showing diffuse membrane positivity for CD99 (original magnification x200).


Immunohistochemical analysis of the tumor. (D) IHC of STAT6 showing partially flaky nuclear positivity (original magnification x200).


Immunohistochemical analysis of the tumor. (E) IHC of CD68 showing partial cytoplasm positivity in giant cells (original magnification x200).


Immunohistochemical analysis of the tumor. (F) IHC for Ki-67 showing some positively stained cells (labeling index of 3%) (original magnification x200).


Short-tau inversion recovery hyperintensity.


T1 hypointensity involving the L4 vertebral body including the pedicles and the lamina (arrow).


(a-c) Computed tomography-guided left sided transpedicular biopsy of L4 vertebral body.


Histopathological images of the computed tomography-guided biopsy from L4 vertebrae,. X40.


X20 H, and ,E stained image - showing bony trabeculae infiltrated by neoplastic cells having hyperchromatic nuclei.


Medical image.


X20 immunohistochemistry image - tumor cells show GATA 3 positivity.


(Axial view) Computed tomography scan shows left side huge psoas hematoma (arrow).


(a-d) Sequential images of computed tomography angiography were suggestive of breech in the left lumbar segmental vessel at L4 level (arrow).


Transcatheter selective embolization at the left L4 segmental vessel (arrow).


17-year-old female with pain in the left heel diagnosed as due to an aneurysmal bone cyst. Lateral X-ray of the left foot shows radiolucent lesion (arrow) leading to expansion on the postero-lateral part of the calcaneus.


17-year-old female with pain in the left heel diagnosed due an aneurysmal bone cyst. MRI on the postero-lateral part of the calcaneus shows a cystic mass lesion in the medullary cavity. T1W.


17-year-old female with pain in the left heel diagnosed due an aneurysmal bone cyst. MRI on the postero-lateral part of the calcaneus shows a cystic mass lesion in the medullary cavity. T2W sequences show heterogeneous hyperintense sclerotic rim (red arrow) surrounding the medullar component and central heterogeneous hyperintense septae formations (green arrow). T2W sequence shows blood level components (blue arrow).


17-year-old female with pain in the left heel diagnosed due an aneurysmal bone cyst. MRI on the postero-lateral part of the calcaneus shows a cystic mass lesion in the medullary cavity. C) Image following intravenous contrast media administration shows contrast enhancement surrounding the lesion (red arrow) and in the septae formations (blue arrow).


Computed tomography chest before bronchoscopy demonstrating widespread airspace disease in the lower lobes bilaterally without volume loss, air bronchograms, or cavitation.


Computed tomography chest showing cavitation in the right lower lobe with an air-fluid level that measures 2.6 cm x 3.2 cm, highly suggestive of lung abscess.


A diffuse ill-defined movable bluish red swelling on right alveolar mucosa in the molar region.


Orthopantograph revealed no significant bony changes.


Fine-needle aspiration cytology stained smear showed well-delineated, tightly cohesive clusters of basaloid cells surrounding mucoid, hyaline globules.


Photomicrograph revealed multiple pseudocystic spaces of variable sizes filled with eosinophilic material.


Bone window.


Noncontrast.


Postcontrast. CT brain.


T1 FLAIR pre.


Postgadolinium.


Medical image.


Intraoperative photograph of the tumour breaching dura.


The tumour had extended through the skull.


Hematoxylin, and ,eosin stain (high-power view).


Hematoxylin and eosin stain (low-power view).


PAS positive.


FLI-1 positive.


MIC-2 positive.


Ki67 30% positive by visual estimation.


Brain imaging and immunohistochemical results. (A) Rapid progressive damage in the bilateral basal ganglia. Upper: Right basal ganglia lesion with patchy abnormal signals before admission. Lower: The bilateral basal ganglia showed patchy abnormal signals after admission. Bilateral basal ganglia lesions with hemorrhage on the right side.


Brain imaging and immunohistochemical results. (B) Mixed density shadow in the bilateral basal ganglia with peripheral parenchymal edema and postoperative resection of right basal ganglia lesions.


Brain imaging and immunohistochemical results. (C) Pathological results from the brain tissues of lesions in the right basal ganglia. Hematoxylin-eosin staining. Fungal spores and hyphae were observed in a small amount of necrotic brain tissue.


EML4-ALK fusion in the present case visualized using the Integrative Genomics Viewer (IGV). Diagrammatic sketch of EML4-ALK fusion result (A).


EML4-ALK fusion in the present case visualized using the Integrative Genomics Viewer (IGV). The IGV display of EML4-ALK fusion in an adenocarcinoma specimen of EML4-ALK fusion results (B).


EML4-ALK fusion in the present case visualized using the Integrative Genomics Viewer (IGV). The IGV display of EML4-ALK fusion in a squamous cell carcinoma specimen of EML4-ALK fusion results (C).


A; Fine needle aspirate showing small lymphocytes, scattered pigmented and nonpigmented cells, and proteinaceous material (cell block HE; magnification x1,000).


B; Immunohistochemical stain showing CD20 B lymphocytes (magnification x1,000).


C; Immunohistochemical stain showing few CD3 T lymphocytes (magnification x1,000).


Initial MRI of the brain with and without contrast. . A large right frontal lobe intra-axial mass with mass effect upon the right ventricular system and a leftward midline shift of approximately 1.3 cm is shown.


Hematoxylin and eosin staining of the tumor.


Synaptophysin immunohistochemical staining of the tumor typical of PNET.


Post-treatment MRI of the brain with and without contrast. . Postoperative changes in the right frontotemporoparietal region are shown. Irregular enhancement at the surgical site extends to the walls of the right lateral ventricle. This was unchanged in subsequent MRI scans.


52-year-old man with silicone-induced penile sclerosing lipogranuloma. (a) Sagittal T2-weighted image of the penis demonstrates heterogeneous lesion, with ill-defined margins surrounding the penis. The mass (arrowheads) was mainly of low signal intensity on T2-weighted images, a finding suggestive of the presence of fibrous tissue. Corpora cavernosa are intact (long arrow). Image shows normal right testis (asterisk).


52-year-old man with silicone-induced penile sclerosing lipogranuloma. (b) Transverse apparent diffusion coefficient map (b = 900 mm2/s) shows heterogeneous mass (arrow) surrounding the penile shaft. The lesion appears mainly isointense when compared to the normal corpora cavernosa (long arrow). The apparent diffusion coefficient value of the mass was 1.53 x 10-3 mm2/s (right corpus cavernosum: 1.49 x 10-3 mm2/s; left corpus cavernosum: 1.60 x 10-3 mm2/s). Normal left testis (arrow).


52-year-old man with silicone-induced penile sclerosing lipogranuloma. Transverse three-dimensional gradient-echo images acquired. Without.


52-year-old man with silicone-induced penile sclerosing lipogranuloma. With the application of the magnetization transfers pulse. The magnetization transfer signal of the mass lesion (arrowhead) was qualitatively lower than that of the corpora cavernosa (arrow). The magnetization transfer ratio (in percent) of the lesion was 67.


52-year-old man with silicone-induced penile sclerosing lipogranuloma. (e) Time-signal intensity curve of the lesion shows an initial upstroke after which the signal intensity gradually increases in the late contrast-enhanced phase.


52-year-old man with silicone-induced penile sclerosing lipogranuloma. Histopathologic evaluation of the excised tissue reveals vacuoles of variable size in the dermis corresponding to exogeneous substance. Multinucleated giant cells and abundant fibrosis is seen around the vacuoles (Hematoxylin and Eosin stain, magnification x20).


Ultrasound findings revealed that the intrascrotal mass (measuring 8 cm in diameter) showed uniformity with a low-echoic lesion (arrow).


Intraoperative findings. The mass was separated from the testis.


A surgical specimen of the intrascrotal mass resected with the skin.


Histologically, the cyst contained keratin flakes and its wall was covered with keratinizing squamous epithelium.


Neuroimaging findings of the patient. Head computed tomography performed on admission reveals a low-density area in the left frontal cortex (a).


Neuroimaging findings of the patient. Axial image from diffusion-weighted magnetic resonance imaging (MRI) reveals no abnormalities that indicate acute cerebral ischemia (b).


Neuroimaging findings of the patient. Fluid-attenuated inversion recovery (FLAIR) shows high-intensity lesions in the left frontal cortex and very thin subdural hematoma (arrows) (c).


Neuroimaging findings of the patient. Gadolinium-enhanced MRI shows leptomeningeal enhancement along the superior frontal gyrus, which is involved in focal cortical hyperintensity in the left frontal lobe of FLAIR imaging (d-f).


Neuroimaging findings of the patient. Gadolinium-enhanced MRI shows leptomeningeal enhancement along the superior frontal gyrus, which is involved in focal cortical hyperintensity in the left frontal lobe of FLAIR imaging (d-f). Note that dural thickening, pituitary swelling, and tonsil herniation are not observed (e and g).


Neuroimaging findings of the patient. Note that dural thickening, pituitary swelling, and tonsil herniation are not observed (e and g).


Neuroimaging findings of the patient. Magnetic resonance venography shows patency of the intracranial main venous system (h).


Intraoperative photographs of the patient. The fluid-attenuated inversion recovery high-intensity lesion is exposed through small craniotomy (a). Note that a tack-up suture is placed (arrows) since the dura mater separates away from the skull spontaneously (a and b), although the brain does not look sunken in the photographs because we lowered the patient's head position to increase the intracranial pressure.


Intraoperative photographs of the patient. Note that a tack-up suture is placed (arrows) since the dura mater separates away from the skull spontaneously (a and b), although the brain does not look sunken in the photographs because we lowered the patient's head position to increase the intracranial pressure.


Intraoperative photographs of the patient. Magnified intraoperative photo shows that the cortical vein is discolored (black).


Intraoperative photographs of the patient.indocyanine green video angiography shows the absence of flow that signifies thrombosis of the vein.


Panoramic X-ray: Diffuse limited borders in the region of the right mandible with bone sclerosis and narrowing of the mandibular canal.


(a-c) Computed tomography: Axial, coronal, and sagittal view: Diffuse limited borders with slight erosion of the right cortical mandible and reduction of trabecular bone microstructure. The mandibular canal was breached.


Magnetic resonance imaging: Axial view, T1: Enlarged, contrast-enhancing mass of the right mandible.


Positron emission tomography/computed tomography: Axial view: Uptake of 18F-fluorodesoxyglucose of the right mandible.


The CT topogram shows that the distal part of VP shunt is lying in the right-upper-quadrant superimposed on the hepatic silhouette.


(a) Abdominal CT scans with oral contrast demonstrates an intrahepatic fluid collection (asterisk) measuring 8.1 x 7.4 cm in the right hepatic lobe.


(b) The VP shunt catheter tip is seen inside the pseudocyst (arrow).


Preoperative.


Follow-up abdominal CT scan at 19 days after VP shunt removal. Axial abdominal CT scan shows the complete resolution of the hepatic CSF pseudocyst.


18F-fluorodeoxyglucose whole-body positron emission tomography-computed tomography scan maximum intensity projection (after potassium chloride infusion): Altered physiological distribution of 18F-fluorodeoxyglucose with markedly increased uptake in almost all major muscle groups, including those of the neck, thorax, abdomen, and pelvis.


18F-fluorodeoxyglucose whole-body positron emission tomography-computed tomography scan maximum intensity projection (12 h after stopping potassium chloride infusion): Normal biological distribution with minimal uptake in muscles.


Pretreatment intraoral photographs.


Normal intraoral appearance during the onset phase.


"Twin-Block" functional appliance used in the patient.


No relevant findings evident on orthopantomogram examination.


Bone marrow aspirate smear (from bone marrow biopsy) stained with May-Grunwald Giemsa showing amastigote forms of Leishmania spp.


Viral load and CD4+ T-cells count evolution following cART initiation and VL diagnosis. TRIP = travel in Greece; H = date of hospitalization; (c)ART = (combined) anti-retroviral therapy; BMB = bone marrow biopsy (VL diagnosis); M1 = first month after cART initiation; M3 = third month after cART initiation; M6 = sixth month after cART initiation; LAmB = intravenous liposomal amphotericin B administrations.


MRI of the patient showing the rt seminal vesicle sandwiched between bladder and rectum.


MRI showing the tumor's relationship to the ureter.


Intraoperative picture showing the tumor.


Enbloc removal of the rt seminal vesicle along with partial cystectomy.


The treatment procedures and corresponding leukocyte counts in the patient's cerebrospinal fluid. Monocytes were predominant among CSF white cells; they had a proportion of approximately between 60 and 90%. The CSF protein level was also elevated to 95.00-125.20 mg/dl. mNGS. P, metagenomic next-generation sequencing of cerebrospinal fluid detected Sarocladium strictum positive; Culture. P, Sarocladium strictum was positive in cerebrospinal fluid culture.


(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the bone window showing an osteolytic lesion with expansion and a periosteal reaction with the appearance of sunrays around the periphery (arrows).


(B) Sagittal reconstructed CT image of the sternum showing the lesion involving the manubrium and almost all the body of the sternum. The lesion is slightly expansile and the cortex is partially destroyed.


(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the soft tissue window showing that the bone marrow of the sternum has been substituted by homogeneous soft tissue.


(B) Axial contrast-enhanced CT image of the manubrium sterni showing marked homogeneous enhancement of the tumor.


(A) T1-weighted sagital image (repetition time/echo time, 590/21 msec) of the sternum showing an area of low signal intensity in the manubrium and body of the sternum.


(B) Short-tau inversion recovery T2-weighted sagittal image (repetition time/echo time, 4150/106 msec) of the sternum showing an area of high intensity in the same region; the soft-tissue mass is clearly demonstrated.


(A) Histopathological examination (hematoxylin and eosin stain; original magnification, x200) demonstrating proliferation of round cells with abundant cytoplasm and eccentric nuclei with coarse chromatin, indicating a plasmacytoma.


(B) Immunohistochemical analysis revealing positive cluster of differentiation 38 staining on the cell membrane (arrow), which is characteristic of a plasmacytoma (original magnification, x200).


Treatment timeline for CRKP infection.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. Histograms compared Chao1 index.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. Shannon index. Of the fecal microbiome in the donor and the patient pre- and post-FMT.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. PCoA plots showed the microbial community variation of the donor and the patient pre- and post-FMT based on weighted UniFrac distance.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. And unweighted UniFrac distance FMT 1W, FMT 3W and FMT 2M represented 1 week, 3 weeks and 2 months after FMT.


The clinical course of the patient (schematic). Hematoxylin and eosin staining of the liver specimen shows some punctate necrosis on the lobule, apoptotic bodies in the hepatic cord, fatty degeneration of hepatocytes, mild inflammation in the portal area, and eosinophil infiltration in the inflammatory necrosis area.


Timeline with relevant data from the episode of care; curves of body temperature and eosinophils count. The blue line shows the body temperature values. The orange line shows the eosinophil counts. Horizontal thick lines show the medications administered. PIP-SBT, Piperacillin-sulbactam.


Imaging features of the patient. (A) Abdominal MRI enhancement showed that the right lobe of the liver scattered flakes, irregular shape, enhanced uneven enhancement on hospital day 2.


Imaging features of the patient. (B) Abdominal CT enhancement showed liver multiple nodules, mass slightly low-density shadow, edge enhancement on hospital day 13.


Imaging features of the patient. (C) Abdominal CT enhancement showed multiple cystic and tubular low-density shadows scattered in the liver, and some showed edge enhancement on day 33.


Imaging features of the patient. (D) Abdominal CT enhancement showed multiple cystic and tubular low-density shadows scattered in the liver, some showed edge enhancement, and a few lesions were smaller than those before on follow-up day 69.


Imaging features of the patient. (E) Abdominal MRI enhancement showed cystic and tubular shadows in the right lobe of the liver, with irregular shapes and edge enhancement in the enhanced part. Some lesions were smaller than before on follow-up day 137.


Imaging features of the patient. (F) Abdominal MRI enhancement showed the right lobe of the liver scattered flakes, irregular shape, enhanced edge uneven enhancement, lesions significantly reduced on follow-up day 418.


Lesion with hypersignal on T2 in the regions of midbrain and right parahippocampus.


Hyperintense lesion on T2 at the midbrain peduncle, mimicking a mesencephalic tumor.


Microphotograph showing clusters of round-to-oval cells (MGG, x100). Inset showing wisps of magenta-colored material (MGG, x400).


Microphotograph showing spindle-shaped endothelial cells (arrow) crossing a cluster of tumor cells (MGG, x400).


Histopathologic sections showing nests and sheets of tumor cells around endothelium-lined small blood vessels (Hand E, x100).


A; Brownish macule with a bluish center on the dorsum of the right foot.


B; Dermoscopy showing a blue-steel pigmentation in one part and a violaceous color in the other, with hypopigmented areas.


C; Histology showing dermal proliferation of spindle cells organized in fascicles with a storiform pattern or in nests. H&E. Original magnification, x10.


D; Melan-A was diffusely positive. Immunohistochemistry. Original magnification, x5.


MRI of the neck with gadolineum. A) Sagittal T1 image illustrating an intramedullary enhancing mass from the cervicomedullary junction to C4. Leptomeningeal enhancement is also present.


MRI of the neck with gadolineum. B) Axial T1 image illustrating the intramedullary mass and leptomeningeal enhancement.


MRI of the neck with gadolineum. C) Axial image of cervical spine illustrating a dumbbell mass extending through C5-C6 neural foramen and paraspinal mass.


MRI of the neck with gadolineum. D) Coronal T1 image illustrating intramedullary mass.


HandE staining illustrating small round blue cells with high mitotic rate, atypical mitosis (red arrow), and pleomorphic nuclei (green bracket) characteristic of a primitive neuroectodermal tumor.


Immunohistomchemical staining. A) GFAP positive b) Synapthophysin positive, illustrating positivity around a binucleated cell (red arrow).


Preoperative radiograph of the patient.


Preoperative CT images demonstrated extensive vertebral body destruction, several facet joint dislocations and mild retrolisthesis of C4 to C5 segment.


Sagittal cervicothoracic MR images demonstrated pathologic contrast enhancement on C4 to T7 segments along with vertebral body involvement and spinal canal compression at the level of C4 to T4. From coronal MR images, a large paravertebral abscess was presented anteriorly.


Postoperative radiograph demonstrated pedicle rod and screw construct that resulted in improved kyphotic deformity.


Abdominal CT scan shows massive ascites.


Umbilical cord cyst images. . A: Umbilical cord cyst first detected at 20 0/7 weeks of gestation (arrow).


Umbilical cord cyst images. B: Umbilical cord cyst was confirmed and a clear image of the connection between the bladder and the umbilicus was found at 22 5/7 weeks of gestation.


Umbilical cord cyst images. C: Doppler velocimetry demonstrated flow around the cyst.


Umbilical cord cyst images. D: Doppler ultrasound examined the size of the cyst.


Fusiform mass in dorsal aspect of the index finger.


Histopathologic examination revealed proliferation of fibroblasts, dposit of osteoid, osteoblasts, and giant cells.


Photograph of a 9-year-old Japanese boy showing corneal infiltrate with surrounding edema in the right eye.


Twelve months after the initial visit, there is slight corneal opacity in the patient's right eye.


Echocardiography of the three presented cases. . Notes: Parasternal long-axis views . (A and B) Case 1: granular sparkling appearance was seen in the interventricular septum (IVS), which was 11.5 mm in thickness.


Echocardiography of the three presented cases. Apical four-chamber views . (A and B) Case 1: granular sparkling appearance was seen in the interventricular septum (IVS), which was 11.5 mm in thickness.


Echocardiography of the three presented cases. . Notes: Parasternal long-axis views . (C and D) Case 2: granular sparkling appearance was seen in the IVS and the lateral wall.


Echocardiography of the three presented cases. Apical four-chamber views . (C and D) Case 2: granular sparkling appearance was seen in the IVS and the lateral wall.


Echocardiography of the three presented cases. . The IVS of Case 2 was less thickened (9.8 mm in thickness), but the left ventricular wall exhibited diffuse hypertrophy with diastolic dysfunction (E/e' 15.55) without valvular dysfunction. (E and F) Case 3: granular sparkling appearance was shown in the IVS and lateral wall, and the IVS was 13.0 mm in thickness.


Echocardiography of the three presented cases. . Are presented. (E and F) Case 3: granular sparkling appearance was shown in the IVS and lateral wall, and the IVS was 13.0 mm in thickness.


The abdominal computerized tomography of Case 3. . Notes: The abdominal wall around the navel was ~3-5 mm in thickness, where FNAB-AFP is usually performed. The white arrow indicates where FNAB of the hip was performed. . Abbreviations: AFP, abdominal fat pad; FNAB, fine-needle aspiration biopsy.


Coronal.


Sagittal.


Axial images of chest computed tomography demonstrating a mass (arrow) invading the right pulmonary artery (PA).


(d) Image obtained during endobronchial ultrasound-guided transbronchial needle aspiration showing the sampling needle inside the intra-arterial mass (arrow) within the lumen of the pulmonary artery.


The fixed smears demonstrate loosely cohesive clusters of spindled cells with irregular elongated nuclei (Papanicolaou).


The air-dried smears show pleomorphic cells; many have large, irregular nuclei and finely vacuolated cytoplasm (Diff-Quik).


The gross resection shows the lumen of the pulmonary artery completely occulted by tumor.


(a) The resected tumor demonstrates spindled cells with a storiform pattern (H and E). (b). Higher magnification shows pleomorphic cells with convoluted to spindled nuclei, often containing nucleoli (H and E).


Surgical specimen. A; Macroscopic view.


Surgical specimen. B; Hematoxylin and eosin staining at 5-fold magnification revealing a fissure, transmural inflammation and architectural changes of the surrounding mucosa.


Surgical specimen. C; Hematoxylin and eosin staining at 100-fold magnification revealing non-caseating granulomas within a draining lymph node.


Magnetic resonance imaging of the lesion on the superior pole of the spleen.


Low power photomicrograph showing variable sized nodules (H&E 40x).


Renal biopsy - light microscopy. . Notes: Light microscopic examination of renal biopsy: (A) trichrome stain showing moderate tubular atrophy, interstitial fibrosis and interstitial inflammation (affecting 50% of cortical area). No interstitial granulomas are seen.


Renal biopsy - light microscopy. (B) Hematoxylin and eosin stain of glomeruli showing glomerular crescent.


Renal biopsy - light microscopy. (C) Trichrome stain of glomeruli showing necrotizing crescent. Out of 19 glomeruli examined, nine showed complete or near complete global sclerosis.


Renal biopsy - immunofluorescence microscopy. . Notes: Immunofluorescence microscopy of renal biopsy (A and B): Immunofluorescence (IF) staining shows weak linear staining of glomerular basement membranes for IgG. Area of non-staining in figure B represents crescent. The IF was also positive for kappa and lambda light chains (not shown). Segmental glomerular tuft staining for IgM, C3, and fibrinogen were also positive (not shown). The linear staining for IgG was not seen in the previous kidney biopsy and suggests the possibility of coexistent pauci-immune glomerulonephritis and anti-glomerular basement membrane nephritis.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (A) Hematoxylin and eosin (H&E) stain of glomeruli showing cellular crescent.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (B) H&E stain of another glomeruli showing cellular crescent.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (C) Trichrome staining of glomeruli showing necrosis (red).


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (D) Trichrome staining of another glomeruli, showing necrosis (red).


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (E) Trichrome staining showing moderate tubular atrophy and interstitial fibrosis. Immunofluorescence staining was negative (not shown). Electron microscopy revealed 30% foot process effacement but no immune type electron dense deposits or endothelial tubuloreticular inclusions (not shown).


(A) Examples of SEMP recorded from proximal (RF) and distal (TA) muscles during stimulation at Th9-10, Th10-11, Th11-12, Th12-L1, and L1-2 levels, in supine position.


(B) Changes in the thresholds, maximal amplitudes, and the latency of the SEMP recorded from proximal (RF and MH) and distal (TA, SOL) muscles with stimulation applied at Th9-10, Th10-11, Th11-12, Th12-L1, and L1-2 levels.


(C) Examples of the SEMP recorded from RF, MH, TA, and SOL with paired pulses stimulation (interstim interval of 50 ms) at Th11-12 level. Black arrow indicate the moment of the stim.


(D) The amplitudes of the SEMP recorded from right and left side during paired stimulation at Th11-12 level.


Examples of M wave.


(F) The amplitudes (%) of the H-reflex recorded from right and left side (n = 10) during performance of Jendrassik maneuver (gray bars). Dotted lines indicate the control values of the H-reflex (100.


(G) Examples of the SEMP recorded from RF and TA during stimulation at Th12-L1 without (black line) and with Jendrassik maneuver (gray line) in supine and in upright (less than 30% body weight support) positions. Gray circles indicate the facilitation of the SEMP bilaterally RF, and in left TA by Jendrassik maneuver.


Reflex recorded form SOL muscle at stimulation intensity varied from 8 to 25 mA with increment of 1 mA. Recruitment curves of the M wave (black line) and the H-reflex (light gray line) presented on the right. (H) The amplitudes (%) of the SEMP recorded from right and left proximal (RF and MH) and distal muscles (TA and SOL) with stimulation at Th12-L1 during performance of Jendrassik maneuver in supine (light gray) and upright (less than 30% body weight support) positions (dark gray) in subject with SCI (n = 4). Dotted lines indicate the control values of the SEMP (100%). Difference marked with an asterisk indicates significance (*p < 0.05).


(A) Examples of the SEMP recorded from TA muscle during stimulation at Th11-12 level in supine and upright (less than 30% body weight support) positions after the first verticalization before (gray lines) and after rehabilitation therapy (black lines).


(B) The thresholds of the SEMP recorded in supine (gray lines) and upright (less than 30% body weight support) position after the first verticalization (black lines) in TA, SOL, RF, and MH (n = 6).


(C) Changes in amplitude and threshold of SEMP recorded from RF, MH, TA, and SOL in supine position before (gray) and after (black) rehabilitation therapy (n = 4).


(D) Example of the SEMP recorded from TA during stimulation at Th11-12 level in upright position (less than 30% body weight support) before (gray line) and after rehabilitation therapy (black line). The black and gray numbers indicate the number of polysynaptic components of the SEMP. Histograms and cumulative percentage of latencies (ms) of polysynaptic components of the SEMP recorded from TA before and after rehabilitation. Counts - frequency of occurrence of latencies of LR in interval of 1 ms. Cumulative percent - cumulative percentage of frequency of occurrence of latencies of LR in interval of 1 ms. Difference marked with an asterisk indicates significance (*p < 0.05).


Positron emission tomography-magnetic resonance imaging fusion with T1 radial volumetric interpolated breath-hold examination with fat suppression acquired in the axial plane showed severely decreased radiotracer activity throughout the liver parenchyma (white arrow) (a).


Corresponding axial T1 radial volumetric interpolated breath-hold examination with fat suppression image (b) revealed generalized decreased magnetic resonance signal in the liver.


Axial positron emission tomography attenuation corrected image.


Showed severe decreased liver uptake (black arrow) which was not present on the nonattenuation corrected images.


Dixon three-dimensional volumetric interpolated breath-hold examination T1-weighted magnetic resonance sequence in the coronal plane demonstrates normal signal intensity in the liver parenchyma (arrow) on the out-of-phase image.


With drop in signal on the in-phase image indicating excessive iron accumulation.


The mu map showed the expanded boundary of the right lung instead of the correctly assigned soft-tissue density of the liver parenchyma (curved arrow) (c).


The coronal attenuation mu map was manually segmented by filling in the faulty liver reconstruction (thin arrow) with soft-tissue density instead of lung tissue (a). The resulting attenuation corrected positron emission tomography image in the coronal plane showed the properly corrected liver parenchyma tracer activity (thin arrow).


Unrelated to the liver, multiple osseous metastases are noted on the study (arrowheads) (b).


Fluorodeoxyglucose positron emission tomography-magnetic resonance imaging scan after oral chelator therapy with attenuation corrected positron emission tomography axial image demonstrating normal fluorodeoxyglucose uptake within the liver (a).


Corresponding T1 radial volumetric interpolated breath-hold examination with fat suppression image showed improved liver signal intensity reflecting decreased iron deposition (b).


Flexible endonasal fiberscopic findings of the left nasal cavity. Hypertrophy of the left inferior turbinate was present, and the left inferior nasal meatus had disappeared (white arrowheads).


A; Large pseudotumoral neoangiogenic lesion of the left perioral area.


B; Magnification of the pseudotumoral neoangiogenic process.


C; Complete crusting after 2 weeks of antiviral therapy.


D; Residual erythematous post-inflammatory pigmentation at 4 weeks.


A; Histology evidencing PG (HE. X10). The black arrow indicates epithelial cell islands in the PG. B, c High-power magnification illustrates some keratinocytes exhibiting CPE. D HSV-I-specific immunostaining (red signal) in giant epithelial cells (black arrows), some exhibiting cytopathic signs (x20).


Fluorescein angiographic images of the right.


Left. Eyes. . Note: Many arch-shaped hyperfluorescent linear lesions running circumferentially are observed in the peripheral fundus of both eyes (arrowheads), and part of these lesions can be seen to run in parallel.


Fundus autofluorescence of the right.


Left. Eyes. . Note: Linear hypoautofluorescent lesions are observed at sites corresponding to the hyperfluorescence in the FA images (arrowheads). . Abbreviation: FA, fluorescein angiographic.


Abdominal computed tomography revealing a right renal enhancing mass about 5 cm in length, accompanied by the parenchyma invasion and pelvis expansion of the right kidney. . Notes:. Cross section.


Abdominal computed tomography revealing a right renal enhancing mass about 5 cm in length, accompanied by the parenchyma invasion and pelvis expansion of the right kidney. Coronal plane.


(A and B) Removing the entire right kidney under robot-assisted laparoscopic nephrectomy.


Pathological features of the surgical specimen. . Notes: (A and B) Microscopic view of the tumor of the right kidney with H&E staining, revealing that tumors were composed of a monotonous population of small round cells. Magnification details:. 40x.


Pathological features of the surgical specimen. . Notes: (A and B) Microscopic view of the tumor of the right kidney with H&E staining, revealing that tumors were composed of a monotonous population of small round cells. 200x.


Pathological features of the surgical specimen. Immunohistochemical staining was positive for. CD99,. 100x.


Pathological features of the surgical specimen. SYN,. 100x.


Pathological features of the surgical specimen. FLI1, and . 200x.


Pathological features of the surgical specimen. Ki67. 100x.


Fluorescence in situ hybridization testing demonstrated that more than 10% of cells were positive indicating EWSR1 gene rearrangement.


Medical image.


68Gallium-prostate-specific membrane antigen positron emission tomography image fused with the corresponding T2-weighted magnetic resonance imaging. Showing focal tracer uptake (red arrow) on the side opposite to the magnetic resonance imaging-detected hypointense lesion (yellow arrow). While no obvious magnetic resonance imaging lesion is seen corresponding to the prostate-specific membrane antigen uptake.


T2-weighted magnetic resonance imaging of prostate showing a hypointense nodule involving the left anterior and posterior transitional zone at the base with low ADC values.


(e) Hematoxylin and eosin-stained specimen of radical prostatectomy showing the acinar adenocarcinoma (from both right and left lobe transition zones).


(a) Chest X-ray showing well-defined homogenous opacity in the left hemithorax (white arrow).


(b) Computed tomography chest showing cystic lesion in the middle and posterior mediastinum (white arrow).


(a) Peroperative finding showing cystic structure below the left lung.


(b) Histopathological examination of the cyst showing columnar lining with mild inflammation. Muscularis mucosa, subcutaneous layer, and muscularis propria can be appreciated confirming the diagnosis of enterogenous cyst.


Characterization of sSMC using chromosome 18 centromere (red) and short arm subtelomeric region (green) fluorescent probes. The result demonstrated that the sSMC is a derivative of chromosome 18.


The physical examination was notable for necrotic-appearing tissue in the entire penis and scrotum, with areas of induration and crepitus.


MRI of the upper arm showing a spindle shaped contrast enhancing mass in the median nerve course.


MRI of the upper arm showing a spindle shaped contrast enhancing mass in the median nerve course. Coronar view. Axial view.


A-B) Preoperative MRI. T1-weighted sagittal and T2-weighted axial images demonstrating the tumour mass with a cystic component and extension into the floor of the fourth ventricle and to the supravermian cistern. Partial obstruction of the fourth ventricle and secondary obstructive hydrocephalus is also observed.


C-D) Two-year postoperative MRI. No apparent residual tumour is shown at T1-weighted sagittal and T2-weighted axial images.


Microscopic features of the rosette-forming glioneuronal tumour. A) Histological features of the tumour showing both a neurocytic and an astrocytic component. Neurocytic rosettes are formed by the neurocytic components.


Microscopic features of the rosette-forming glioneuronal tumour. B) The eosinophilic core at the centre of the neurocytic rosettes displays strong positive staining with synaptophysin.


Microscopic features of the rosette-forming glioneuronal tumour. C) The astrocytic components of the tumour showed that the tumour cells had bipolar and spindle processes with positive immunostaining of GFAP.


Microscopic features of the rosette-forming glioneuronal tumour. D) The MIB-1 labelling index was about 5-7%. Original magnifications 400x.


A-B) MRI scans 48 months after the initial procedure. T1-weighted sagittal and T1-weighted axial contrast enhanced images reveal a nodular lesion close to the roof of the fourth ventricle.


C-D) T1-weighted sagittal and T2-weighted axial MRI images two years after radiosurgery show stabilisation of the lesions.


Treatment planning for gamma knife radiosurgery. A) Sagittal view.


Treatment planning for gamma knife radiosurgery. B) Axial view.


Treatment planning for gamma knife radiosurgery. C) Coronal view.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Lung windows from computed tomography of the abdomen and pelvis demonstrate nodules in the left (red arrow) and right (yellow arrow) lower lobes.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Follow-up computed tomography chest on lung window demonstrates stability of one of the larger nodules in the left lower lobe (red arrow). Additional nodules (yellow arrows) are seen at slightly different levels than on prior study due to differences in positioning and level of inspiration.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Fused images from F-18 fluorodeoxyglucose positron emission tomography- computed tomography demonstrate the index lesion without abnormally increased glucose metabolism.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma (PHG) associated with idiopathic thrombocytopenic purpura. A) x10 magnified H and E, stained microscopy of the two nodules from wedge resection (long arrows) shows clusters of lymphoplasmacytic infiltrate (short arrows) peripherally. B) x20 magnified view demonstrates whirled layers of collagen (dark pink) around small blood vessels (*), consistent with PHG. No multinucleated giant cells are present.


(A-D) Abdominal CT revealed a soft tissue nodule measuring 1.3x1.5 cm in the subcutaneous soft tissue of the right abdominal wall and a cystic density mass measuring 9.9x8.7 cm in the peritoneal cavity.


Abdominal CT scans before and after anlotinib therapy. . Notes: (A) Before anlotinib therapy, the CT scan shows the size of the enlarged right inguinal lymph node was 29.3x19.8 mm.


Abdominal CT scans before and after anlotinib therapy. (B) Before anlotinib therapy, the CT scan shows the size of the omental lymph node was 17.8x14.9 mm.


Abdominal CT scans before and after anlotinib therapy. (C) After two cycles of anlotinib treatment, the CT scan shows the size of the enlarged right inguinal lymph node was 12.2x10.7 mm.


Abdominal CT scans before and after anlotinib therapy. (D) After two cycles of anlotinib treatment, the CT scan showed the size of the omental lymph node was 9.9x7.9 mm, respectively.


Gross image of the uterus and tumor.


Mixed components: a close transition from the endometrial adenocarcinoma to the yolk sac tumor areas (hematoxylin and eosin, 100x).


Immunohistochemical staining results for alfa-fetoprotein confirm the existence of two components of endometrial adenocarcinoma and yolk sac tumor.


Axial.


Coronal. T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesion with parenchymal invasion along the right frontal lobe (arrow).


Axial ,. Along the falx cerebri.


Coronal. Right temporal lobe.


Sagittal. T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesions through the frontal sinus, and . Right sphenoid wing. (arrows).


Sagittal. T1-weighted magnetic resonance imaging showing a contrast-enhancing sinonasal mass with intracranial extension through the cribriform plate into the anterior cranial fossa, maxillary, and sphenoid sinuses.


Sagittal T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesions posterior to C2 vertebral body.


Posterior to T9-T10 disc space.


Along the posterolateral dura at the L3-L4 level. (arrows).


A 4-month-old female with emesis. Coronal T2 3D magnetic resonance cholangiopancreatography shows the pancreas divisum with the main pancreatic duct draining into the duct of Santorini (arrow). The common bile duct drains into a complex conglomeration of pancreatic head cysts (asterisk). The common bile duct is mildly prominent, and there is ascites.


Same patient as above. Coronal T2 3D magnetic resonance cholangiopancreatography shows the 1.9 cm common cyst (arrow) that drains the duct of Santorini and the common bile duct. There are multiple cysts and ducts that extend throughout the pancreatic head with multiple connections to the duodenum (asterisk).


Same patient as above. Axial T2 fat-saturated image shows a large pancreatic pseudocyst (asterisk), with layering debris, exerting mass effect on the pancreatic head. There is ascites.


Axial view of a CT with contrast of neck showing peripherally enhancing fluid collection at the left submandibular space along with extensive gas collection extending from the left submandibular to the left parapharyngeal space.


CT scan with oral and rectal contrast (R) showing a pelvic mass with multiple heterogeneously enhancing soft tissue masses with central necrotic areas within pelvis not separately seen from the ovaries (EST).


Sagittal section showing heterogeneously enhancing soft tissue lesions within omentum (OM), M- pelvic mass seen indenting bladder base ,. Bowel. Loops are displaced upwards.


Intraoperative omental nodular metastatic deposits (OD).


Metastatic deposits (D) on the descending colon (DC).


H&E x 20: biphasic neoplasm showing both benign epithelial component and sarcomatous mesenchymal component.


Immunostain CK7x20:epithelium is positive for CK7 (brown).


Immunostain, CD10x- Mesenchymal component is positivity for CD-10 (brown).


Thyroid tuberculosis in a 45-year-old patient. (A) Sonogram image revealing an ovoid-shaped, heterogeneous, hypoechoic nodule with ill-defined margins in the left thyroid lobe, resembling a cystic nodule with fluid space (white arrow).


Thyroid tuberculosis in a 45-year-old patient. (B) Color Doppler examination revealing punctated and banded flow signals around the nodule.


Repeat ultrasound examination at three days post-admission. (A) Longitudinal sonograms revealing a nodule, closely adjacent to the left salivary gland and partially protruding from the upper pole of capsular tissue into the left lobe of the thyroid.


Repeat ultrasound examination at three days post-admission. (B) A blood flow signal can be observed around the nodule.


Repeat ultrasound examination at three days post-admission. (C) Fine-needle aspiration cytology of the nodule.


Repeat ultrasound examination at three days post-admission. (D) The aspiration yielded reddish pus that was revealed to be red blood cells with necrosed materials.


Repeat ultrasound examination at three days post-admission. (E) Follicular epithelial cells on a bloody background, with clusters of purple-stained colloid and a field of red-stained granular caseous necrosis.


Repeat ultrasound examination at three days post-admission. (F) Multifocal granulomatous nodules inbetween atrophic thyroid follicules, with fibrous tissue proliferation and chronic inflammatory cell infiltration. (E anf F: stain, hematoxylin and eosin; magnification, x200).


Repeat ultrasound examination six months after the initiation of anti-tuberculosis medication. (A) Significant shrinkage and echo enhancements can be observed. The nodule is solid and well-defined, with two tiny calcifications inside (white arrows).


Repeat ultrasound examination six months after the initiation of anti-tuberculosis medication. (B) Color Doppler examination revealing punctate and strip-shaped blood flow around and inside the nodule.


Contrast-enhanced computed tomography scan of the abdomen showing a diffuse circumferential thickening of the distal pyloric antrum of the stomach with a few ulcerative areas.


A; On magnetic resonance imaging, an heterogeneous multinodular mass was observed on sagittal T1-weighted images (TR/TE: 1,200/120). Dark signal nodules, compatible with hemosiderin deposition, were identified.


B; On macroscopy a multinodular lesion was evident in the leg and in the thigh showing variegated colour.


C, d On haematoxylin and eosin staining the lesion showed synovial-like mononuclear cells without cytologic atypia, admixed with multinucleate giant cells.


Preopertaive axial view of current case showing. T1 (without contrast).


T1 (with contrast).


T2 (without contrast).


Immunohistochemically, the cells were positive for CD99. The complete reactivity pattern of the specimen is shown in Table 2.


The patient showing left eye proptosis with inferior displacement of the globe.


(a) MRI, coronal view of a heterogeneous intermediate signal (white arrow) of the left superior orbital mass, infiltrating the superior rectus muscle.


(b) The transverse view of the same heterogeneous mass (black arrow) displacing the globe anteriorly (proptosis).


Mature adipocytes (black arrow) intermingled with zones of atypical stromal cells (white arrow) (200x, H & E stain).


A; Hematoxylin and eosin, x10. Skin punch biopsy from right leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis.


B; Hematoxylin and eosin, x40. Skin punch biopsy from the right leg exhibits almost confluent parakeratosis and an absent granular layer with Munro's microabscesses. Some dilated papillary dermal vessels are noted.


C; Hematoxylin and eosin, x20. Skin punch biopsy from left leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis. Absent granular layer is evident, with denuded foci. Also seen is a hair follicle with parakeratotic plugging.


D; Hematoxylin and eosin, x40. Skin punch biopsy from left leg exhibiting almost confluent parakeratosis and an absent granular layer with Munro's microabscesses.


A; Improvement of both legs after 52 weeks of treatment with etanercept.


B; Improvement of both elbows after 52 weeks of treatment with etanercept.


Yellowish brown plaques and nodules around the eye.


Epitheloid histiocytic granulomas in the dermis with Touton and foreign body giant cells. The inset picture shows foci of the degenerated collagen with Touton giant cells.


Intra-operative photograph showing the released full thickness flap over the cheek.


Color Doppler ultrasound imaging. a on November 3, 2017 (23 + 4 weeks of gestation), color Doppler ultrasound imaging showed a hyperechogenic mass in the fetal left ventricle, measuring 1.8 cm x 1.57 cm, broadening of the left lateral ventricle (1.11 cm) and a strong dot-like echo in the left ventricle; b on December 7, 2017, color Doppler ultrasound reexaminations displayed multiple strong echoes in the fetal left ventricle (measuring 3.3 cm x 2.03 cm), compression of the left ventricular outflow tract, obvious enlargement of the tumor, and a 0.92 cm internal diameter of posterior horn of the left lateral ventricle.


Chromosomal microarray analysis detects a 1.8 Mb-duplication of the chromosome 15q13.2q13.3 region containing 7 genes, which occurs in the region between BP4-BP5 on chromosome 15q13.3.


Clinical response to long-term immunotherapy and the effect of surgery. (A) Schematics showing the time line of patient's diagnosis, treatment and response.


Clinical response to long-term immunotherapy and the effect of surgery. (B) Computed tomography scans and Magnetic resonance imaging showing clinical response to immunotherapy and the effect of surgery.


Clinical response to long-term immunotherapy and the effect of surgery. (C) The result of PD-L1 staining before immunotherapy.


Clinical response to long-term immunotherapy and the effect of surgery. (D) PET-CT scan before Lung tumor resection. TC, paclitaxel+carboplatin; Pembro, pembrolizumab.


Neck lymph node (LN) shows metastatic extremely well differentiated papillary thyroid carcinoma (EWD-PTC) E stain, x12.5.


Inset x400) with focal positivity of CK19. X400) in the first metastatic lesion.


The left thyroid shows follicular variant papillary thyroid carcinoma (FVPTC) without capsular (arrow) invasion E stain, x40.


Loss of CD56. X40) in second episode.


The LN also shows metastatic EWD-PTC E stain, x12.5.


Inset x400) with focal positivity of CK19. X400).


Neck lymph node (LN) shows metastatic extremely well differentiated papillary thyroid carcinoma (EWD-PTC) E stain, x12.5, and . The left thyroid shows follicular variant papillary thyroid carcinoma (FVPTC) without capsular (arrow) invasion E stain, x40, and . The LN also shows metastatic EWD-PTC E stain, x12.5, and . CD56. X400) in the second metastatic lesion. The skull lesion shows metastatic FVPTC E stain, x100.


The skull lesion shows metastatic FVPTC E stain, x100.


CD56. X400).


Sagittal CT scan image showing a mesenteric amorphous aggregate surrounding the portal vein (arrows). The contrast media is visualized in the perianal area (arrow head) without appropriate visualization of the lymphatic system.


Transverse CT scan image showing a contact (star) between the caudal extremity of the right lobe of the pancreas (arrow) and the mesenteric aggregate (arrow head).


Hematoxylin and eosin staining. Pancreatic carcinoma displaying a sheet of large polygonal neoplastic cells with moderate anisokaryosis and a low mitotic index (star) with residual pancreatic acini (arrow head).


Hematoxylin and eosin staining. Mesenteric fat showing necrotic area (star) surrounded by vacuolated macrophages (arrow head).


(A)
Chlamydia psittaci detection in bronchoalveolar lavage fluid (BALF) using metagenomic next-generation sequencing (mNGS) on October 25, 2020.


Positron emission tomography-computed tomography chest image demonstrates a localized mass in right posterior mediastinal/ paraspinal region with maximum standardized uptake value of 6.6.


Field's stained smear shows cohesive group of cells on a myxoid background (MGG, x2.5). This smear pattern correlates with groups of tumor cells surrounded by fibrous septa on histology. High power view of vacuolated cells somewhat resembling physalipherous cells, but differentiated from them by pleomorphic large nuclei and prominent nucleoli (inset).


Loosely cohesive epithelioid cells with eccentric nuclei, prominent nucleoli, and ample cytoplasm resembling adenocarcinoma. Note the cell showing vacuolated cytoplasm with magenta droplet (arrow) (myxoid background, x63). Mucicarmine stains were negative to faintly positive.


Clusters of epithelioid cells with abundant, poorly defined cytoplasm, mildly pleomorphic nuclei with irregular nuclear membranes (grooves and notches), prominent eosinophilic nucleoli, and chromatin condensation. Rare signet-ring like cells are seen. The myxoid stroma is less obvious in the Papanicolaou (Pap)-stained smear (Pap, x63).


Immunohistochemical results. Tumor cells are positive for calretinin, WT-1, and D2-40, and negative for high molecular weight keratin and thyroid transcription factor-1 supporting mesothelial origin. Mucicarmine stain is negative excluding adenocarcinoma.


Dorsal plane whole-body CT, fused PET/CT, gray-scale PET, and axial plane fused PET/CT at the level of the kidneys (left to right). Showing increased 18F-FDG uptake in the region of the left medial retropharyngeal lymph node mass, as well as the nasal tissues, nasopharynx, right lung, mediastinum, liver, and both kidneys. Histopathology post-mortem confirmed large-cell high-grade lymphoma causing increased uptake in the kidneys. The increased 18F-FDG uptake in the urinary bladder is a normal finding. The increased 18F-FDG uptake in the small intestine is likely due to normal digestion.


Gingival recession in tooth 4.1.


Removal of epithelial-connective tissue from the palate.


Epithelial-connective tissue graft.


Positioning the amniotic membrane at the donor site.


Horizontal mattress sutures.


Resolution of gingival recession 30 days after the procedure.


Reepithelialization of the palate 14 days after HAM grafting, before.


After. Removal of stitches.


Appearance of the palate 30 days after the procedure.


Thyroid FNA ThinPrep: On the left are the mesothelioma cells, which are in three-dimensional groupings compared to the Hurthle cell population on the right, that forms two dimensional sheets. The mesothelioma cells have waxy cytoplasm with multiple nucleoli and more nuclear variation. The Hurthle cell population has abundant granular cytoplasm and generally one nucleolus. Papanicolaou stain x600.


Surgical Resection: Panel A (x40) shows nodular thyroid tissue. Panel B (x40): Two populations of cells seen within the nodule. Hurthle cells (black arrow) shows abundant pink cytoplasm. However, the tissue contains mostly mesothelial cells (white arrow) which are smaller polygonal cells with less cytoplasm. Panel C (x100): Mesothelial cells are positive for keratin 5/6. Panel D (x100): Mesothelial cells are positive for calretinin. Other immunostains (not shown) that were positive in the mesothelial cells include CK7 and HBME1, while TTF-1 and Thyroglobulin were both negative.


A; Large tumor on the left side of the head (male, 79 years).


B-d The waxy tumor exhibited a sulcated, mostly yellowish and reddish surface, and in some areas hemorrhages. A punch biopsy showed amorphous eosinophilic material in the dermis (b), and these masses extended down to the subcutis.


Immunohistochemistry showed that the entire dermis and parts of the subcutis were filled with amyloid consisting of both kappa and lambda immunoglobulin light chains (c, d).


E; In electron microscopy, the typical amyloid fibrils (7-10 nm in diameter) were found (bar = 0.5 microm).


The patient at follow-up 1 month after surgery. He showed no signs of local tumor recurrence or systemic disease.


(a) Maximum intensity projection image - increased fluorodeoxyglucose avidity in the midline of the neck.


(b) Fused axial image - markedly increased metabolic activity in left-sided mass lesion (large single arrow). Another large solid-cystic mass lesion arising from the right lobe of the thyroid gland with mildly increased fluorodeoxyglucose uptake (small double arrow).


(c) Axial computed tomography scan of the neck - left-sided mass lesion is not separable from the isthmus of the thyroid, thyroid cartilage, and obstructing the supraglottic larynx.


(d) Small soft-tissue parenchymal nodules in the lingular segment of the left lung with minimally increased metabolic activity.


Axial section of follow-up positron emission tomography/computed tomography scan shows the partial regression of the metabolically active thyroid mass. The benign lesion in the right lobe of thyroid remains unchanged.


Anterior Posterior view of the right arm taken in the emergency department demonstrating significant subcutaneous free air.


Lateral view of the right arm taken in the emergency department demonstrating significant subcutaneous free air.


Coronal chest computerized tomography scan demonstrating subcutaneous free air throughout the chest secondary to a pneumothorax.


Axial chest computerized tomography scan demonstrating subcutaneous free air throughout the chest secondary to a pneumothorax.


Lateral view of the right arm taken eight days after initial presentation demonstrating resolution of subcutaneous free air.


(a) Fundus photo oculus dextrus showing disc edema and retinal straie.


(b) Fundus photo oculus sinister normal.


B-scan ultra sound oculus dextrus showing typical "T sign.


Fundus fluorescein angiogram oculus dextrus showing leak from disc.


(a) Magnetic resonance imaging brain and orbit - isointense diffuse thickening of right ocular coats.


(b) Magnetic resonance imaging brain and orbit - T1-weighted image with contrast - showing hyperintense diffuse thickening of the right ocular coats.


(c) Magnetic resonance imaging brain and orbit - T2-weighted image showing hypo intense diffuse thickening of right ocular coats.


(a) Fundus picture oculus dextrus posttreatment - absent disc edema retinal straie.


(b) Optical coherence tomography macula oculus dextrus - eye - flattening of retinal straie posttreatment.


Cut-surface of the mass shows whitish, nodular, round, glistening areas with yellow-brown soft areas in the centre.


FISH analyses with chromosomes 4 and 22 probes. . Notes: Image showing the results of FISH on a metaphase spread, with painting probes for chromosomes 4 (orange) and 22 (aqua). The yellow arrows indicate normal chromosome 4 (orange - in the upper), residual chromosome 4 (orange - in the middle) and chromosome 22 (aqua); the red arrow indicates derivative chromosome 4 (orange + aqua). . Abbreviation: FISH, fluorescence in situ hybridization.


Brain MRI in the 7th . FLAIR and DWI show a mass involving the right basal ganglia and thalamus (a, b).


Brain MRI in the 7th . The mass was clearly enhanced (c).


9th. Week after admission. Two weeks later, the mass had enlarged (d-f).


Postsalvage chemotherapy biopsy.


Soft, nontender compressible diffuse swelling involving the left parotid gland.


Simple magnetic resonance imaging of the neck.


Scanner view shows cystic cavity lined by thin epithelium and subjacent C. T with Germinal centers.


Highpower view of cystic cavity lined by thin epithelium & showing subjacent C. T with germinal centers.


High-power view showing cystic cavity lined by thin epithelium and subjacent connective tissue with germinal centers.


High-power magnification showing germinal centers with subjacent connective tissue.


Abdominal computed tomography after 3 months of treatment with everolimus showed stationary pancreatic neuroendocrine tumors.


White arrow) but decreasing liver metastasis nodule numbers , suggesting a partial response to everolimus.


FNAC smears showing cohesive clusters of small, uniform, ovoid to round epithelial cells (MGG, x100).


Preoperative Xray.


CT scan.


CT scan done during CT guided biopsy.


MRI showing the tumor compressing the cord.


MRI showing the tumor arising from the D7, D8, D9 vertebral levels.


Intraoperative image showing a friable tumor mass compressing the cord.


Excised tumor mass.


Histopathological slide showing polygonal stromal cells, osteoclastic giant cells and many hemosiderin laden macrophages on high power view.


Whole body fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) maximum intensity projection image.


Axial fused PET/CT showed a intense uptake in the soft-tissue lesion in the left breast.


Liver lesions.


Bone lesion.


Axial CT showing lytic bone lesion in D4 vertebra.


Immunohistochemistry staining showing positive for chromogranin.


Synaptophysin.


Midsagittal images of computed tomography scan of the lumbar spine.


Coronal imagining of the lumbar spine demonstrating a left L5 transverse process fracture.


Midsagittal imaging of the lumbar spine demonstrating a large fluid collection of subcutaneous tissue in the lumbar spine.


Coronal imaging of the lumbar spine, further demonstrating a large fluid collection of the lumbar spine subcutaneous tissue.


Extraoral view showing facial asymmetry.


Birds eye view showing deviated chin button toward right side.


Intraoral view showing enlargement of the maxilla and the mandible.


PNS view showing expansile, ill defined mixed radiopaque-radiolucent lesions in the frontal bone, ground glass radiopaque lesion in the right maxilla.


OPG showing extensive multilocular lesion of the right ascending ramus extending upto the mandibular left first molar.


Axial.


Sagittal. T1-weighted magnetic resonance imaging scans revealed a heterogeneous osteolytic mass in the right parietal region.


The lesion intensely enhanced after contrast administration in the axial.


Sagittal. T1-weighted magnetic resonance imaging scans.


Selected axial sections (a-c) of cranial computed tomography scans demonstrating the skull defect with associated large subgaleal and extradural hematoma.


Photomicrograph showing polymorphic infiltrate of Langerhans histiocytes (polygonal cells with kidney-shaped and elongated nuclei had longitudinal groove) admixed with many eosinophils.


Six-year follow computed tomography scan without.


With contrast. Demonstrating no recurrence and spontaneous bone formation and closure of the skull defect.


(a and b) A three-phase whole body 99mtechnetium labeled methylene diphosphanate bone scan showing focal hot spot in sacrum (arrow) with no increased vascularity. There were no other abnormal hot spots in rest of skeletal survey.


Myelo computerized tomography (CT) of pelvis. Initial and a 6-h delayed CT scans, revealed no free communication between the Tarlov cyst (TC) and subarachnoid space. However, surrounding sacral bony erosion around TC in S2 level produced the increased methylene diphosphanate uptake in the bone scan as a result of new bone formation.


Patient's pedigree. Arrow indicates proband. Proband's mother and husband are indicated by an asterisk. Only these family members were tested. 'N' means normal karyotypes. Only in proband both cytogenetic and FISH testing were performed.


Histological view of biopsy specimens obtained from. Surgical excision of the supraclavicular fossa lymph node.


Fiberoptic bronchoscopy. The two images show caseous necrosis, epithelioid cell nodules and Langhans giant cell. Magnification, x100.


Pretreatment clinical findings of periorbital necrobiotic xanthogranuloma demonstrating multiple yellow, firm papules coalescing into plaques and resulting in cicatricial lagophthalmos.


Skin biopsy of necrobiotic xanthogranuloma lesions revealing a diffuse dermal infiltrate of histiocytes with multinucleated giant cells along with cholesterol clefts, Touton forms, and geographic necrobiosis. Hematoxylin and eosin, x100.


Treatment outcome of periorbital lesions of necrobiotic xanthogranuloma after 16 cycles of intravenous immunoglobulin.


Composite photomicrographs. (a) Lesion with superficial epithelium and connective tissue stroma with numerous amelobastic follicles (x4 OM.


Composite photomicrographs. (b) Follicle showing ameloblast-like cells, stellate reticulum and dentinoid tissue (x10 OM.


Composite photomicrographs. (c) Numerous ameloblastic follicles seen with interspersed dentinoid-like material (x10 OM.


Composite photomicrographs. (d) Dentinoid secreted by odontoblast (x40 OM*). *Original magnification.


Anteroposterior and lateral radiograph of the right leg showing lytic lesion with large soft-tissue component and hair-on-end periosteal reaction in mid-diaphysis of tibia.


Left eye. Total ptosis.


Left eye. Total ophthalmoplegia.


(a) H and E-stained section of nasopharyngeal punch biopsy specimen showing nests of small round blue cells, (b) Strong CD99 immunoreactivity.


Single, non-tender, pedunculated, polypoid growth, about 6 x 7 cm, hanging from the left labium minus (P), and ,minimal swelling of the left labium majus.


Multiple "knife-cut" ulcers on the external genitalia, in the inguino-crural fold, and in the interlabial creases.


Multiple typical "knife-cut" ulcers on the external genitalia in the inguino-crural fold,. Interlabial creases.


Natal cleft.


Massive edema of genitalia more marked on the left labium majus.


Case 1: (a) Noncontrast computerised tomography axial images of 29-year-old male following road traffic accident developed intraparenchymal contusion (broad arrow) showing hemorrhagic contusion in right frontotemporoparietal lobe causing transfalcine herniation with midline shift. SDH was seen in right frontal region.


(b) Axial bone window sections showing fracture of right frontotemporoparietal bone (long arrow) with depressed fracture involving right orbital roof (not shown).


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. (a and b) Noncontrast computerised tomography showed two similar appearing well defined hyperdense lobulated mass.


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. (a and b) Noncontrast computerised tomography showed two similar appearing well defined hyperdense lobulated mass. One measuring approximately 2.2 cm x 1.5 cm around right sylvian fissure is seen abutting insular cortex with surrounding gliotic changes and another rounded hyperdense mass noted in right temporal lobe (long arrow in a and b).


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done.


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. Axial postcontrast brain sections showing prominent peripheral enhancement of lesions in insular cortex and temporal lobe (broad yellow arrow in c.


(a) MRI, T1W image showing hypointense lesion in the left frontal lobe.


(b and c) showing peripheral enhancement on contrast administration.


The vessels showing perivascular infiltrate of lymphocytes and neutrophils causing wall destruction. H and E, x100.


MR angiography in the postoperative period shows focal narrowing of vessels in the left frontal region, indicating vasculitis.


Necrotizing fasciitis of the patient's left leg at admission. Note violet purpuras with unclear margins and bullae of lateral malleolar area.


Intra-operative findings:. Right hand.


Left lower leg. It was easy to separate the fascia from the subcutaneous tissue.


Histopathological findings of the soft tissue. (A) The subcutaneous fat tissues showed edematous changes and infiltrates of inflammatory cells mixed with neutrophils (H&E stain, x 100).


Histopathological findings of the soft tissue. (B) It shows inflammatory infiltration and thrombosis in the blood vessels (H&E stain, x 400).


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (A) Pedigree of the family: electropherograms depict the relevant sequence section around the causative C-to-T transition at position c.3028 in exon 23 and the generation of a premature stop codon at position p. Q1010.


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (B) Physical features and final height (133 cm) of the patient (reproduction with permission of the patient).


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (C) Chest CT demonstrates bronchiolitis obliterans, lower lobe right side: small area of ground-glass opaque consolidation, swelling, and widening of bronchial tubes.


Medical image.


Lateral. Radiograph demonstrating hardware failure and destruction of the tibiotalar joint with severe valgus deformity and non-union.


Lateral. Radiographs following removal of hardware, placement of tibiotalar antibiotic spacer and ringed external fixator.


Lateral. Radiographs following definitive ankle fusion after eradication of infection.


Right lower extremity (A-C) following successful infection eradication and tibiotalar fusion demonstrating healing of prior surgical sites and sinus tracts.


Preprocedural presentation of the patient.


Micro-retention beads sprinkled on wax pattern.


Bresol investment liquid and investment material.


Seven grams of polyetheretherketone dental material.


For2Press unit used for vacuum pressing the material.


Polyetheretherketone framework try in.


Postcementation.


O. P. G. Revealing bone loss from the alveolar ridge on the right side.


Excised specimen.


Post operative healing after 7 days.


Photomicrograph.


Intra oral growth.


Extra oral view.


Computed tomography images of the patient. A; Nonenhanced computed tomography image.


Computed tomography images of the patient. B; Arterial phase.


Computed tomography images of the patient. C; Venous phase.


Computed tomography images of the patient. D; Delayed phase.


Medical image.


Immunohistochemistry. For CD79a.


Digital subtraction angiography image showing mild stenosis in the thoracic aortic lesion without an obvious intimal flap.


The implanted stent.


Axial nonenhanced CT image.


CTA. Showing enlargement of the false lumen three months after stent implantation, with nonhomogeneous enhancement and mediastinal extensions of the false lumen, which was interpreted by radiologists in our hospital and other medical centers during follow-up as an endoleak and periaortic hematoma.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. T1WI image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. Contrast-enhanced T1WI image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. Showing a nonhomogeneous enhancement of the "false lumen," which correspond to the hyperintense regions in DWI (b = 800 s/mm2) image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. T2WI image. Showing the heterogeneous of "false lumen" with bleeding area (green arrow).


Histopathology of aortic tissues showed that the tumor was composed of malignant spindle cells and demonstrated nuclear pleomorphism and atypia (hematoxylin and eosin staining x200).


Frontal view of fluoroscopic images during inguinal injection of Lipiodol. At abdominal level there is opacification of lymph vessels with drainage of Lipiodol into the cysterna chyli and thoracic duct (TD). Image of occlusion of the TD on the passage from abdominal to thoracic level. Black arrow: droplets of ethiodized oil at the passage from the inferior caval vein to the TCPC conduit, revealing early lymphovenous shunting. At thoracic level there is drainage of Lipiodol through multiple collaterals to hilar, peribronchial, mediastinal, and axillar dilated lymph vessels. Right mediastinum is more affected than the left.


Cone-beam computed tomography image during Lipiodol-based lymphangiography shows filling of several mediastinal abnormal dilated lymph vessels, predominantly peribronchial right (yellow arrows). This is similar to the fluoroscopic image of Figure 1.


Operative procedure. A; The hilar Glissonean pedicle was taped to clamp the inflow from the proper hepatic artery without cystic artery flow.


Operative procedure. B; Under ICG mode, the stained area of the hepatic parenchyma was marked by electrocautery to identify the perfusion area of the cystic vein.


Operative procedure. C; Extended cholecystectomy was performed along the demarcation line.


Operative procedure. D; We performed lymphadenectomy of the hepatoduodenal ligament. ICG, indocyanine green.


CT for head segment.


Clinical image of eccrine spiradenoma presenting as erythematous nodule on the scalp.


Trichoscopy of eccrine spiradenoma showing "serpentine-like" linear reddish structure (yellow arrow) surrounded by whitish areas (black arrows).


Partial karyotype of Normal Chromosome and Abnormal chromosome 6 with Ideogram of normal Chromosome 6.


Giemsa Banded Karyotype image of wife.


Giemsa Banded Karyotype image of Husband.


Partial karyotype of normal and abnormal chromosome 1 and 9 and normal chromosome ideogram respectively.


Abdominal ultrasound of the patient. . A hyperechogenic 5.6 x 7.3 cm anchor is observed in segment V of the right hepatic lobe suggestive of an incidental hemangioma.


Myelolipoma evaluation. . Surgical specimen, macroscopic. Amado Polyclinic, Maracaibo- Edo Zulia (10/04/2013).


Medical image.