(B) Radiographic imaging of Case #2. Thoracic computed tomography scan revealed bilateral interstitial lung disease with lower lung predominance, thickened alveolar septa, condensations, and traction bronchiectasis.


Biological follow-up and treatment of Case #2. The full curve represents the regression of anti-MDA5 antibodies titers (expressed as relative intensity) and the dotted curve the evolution of serum ferritin level. Five plasma exchanges were performed (arrows), preceded and followed by cyclophosphamide infusions (depicted with stars). MDA5, melanoma differentiation-associated gene 5.


Preoperative stone burden.


Poor intraoperative observation.


Pre-operative intra-oral photograph showing missing teeth, root stumps and poor oral hygiene of the patient in the case report.


Severely atrophied alveolar ridge and partial anodontia of the patient in the case report.


Orthopantomogram showing horizontally impacted third molars and reduced bone density with severe bone atrophy in both maxilla and mandible of the patient in the case report.


Lateral cephalogram showing prognathic relation of the mandibular to the maxilla of the patient in the case report.


Upper gastrointestinal endoscopy images immediately after hematemesis. A; A longitudinal extension of reddish or wine-colored mucosal thickening (asterisk), obstructing the esophagus, is seen from the midesophagus to the esophagogastric junction.


Upper gastrointestinal endoscopy images immediately after hematemesis. B; The submucosal hematoma (two asterisks) is displacing the esophageal mucosa (asterisk) toward the gastric cavity at the esophagogastric junction. A part of the displaced mucosa has a laceration with bleeding.


Upper gastrointestinal endoscopy image 7 days after surgery. The esophageal submucosal had almost disappeared, and the slough had adhered to the mucosal laceration at the esophagogastric junction.


Preoperative Surgical Plan. . Preoperative surgical plan showing the swelling in the anterior area of the mandible, causing buccal and lingual bone expansion and displacement of the incisors.


Gross examination of the incisional biopsy. . Gross examination of the incisional biopsy revealed two firm pieces of 2.5x2x1.2 cm in size; they were reddish white in color and solid in consistency.


Photomicrograph of old incisional biopsy. . (
a) Photomicrograph of old incisional biopsy showing heavily scattered multinucleated giant cells (short arrow) in a background of highly cellular fibrous stroma consisting of mononuclear stromal cells (long arrow) and extravasated red blood cells (original magnification 40x).


Photomicrograph of old incisional biopsy. (
b) Newly formed bone trabeculae and osteoid tissue (star) were noted at the periphery of the lesion (original magnification 40x).


Computed tomography (CT) of the lesion. . (
a) CT of the lesion showing a well-defined multilocular radiolucency with diffuse flecks of radiopacities, extending from the right impacted third molar area to the left first molar area.


Computed tomography (CT) of the lesion. (
b) CT of the lesion showing perforations in the buccal and lingual cortical plates.


Gross examination of the excised lesion. . Gross examination of the excised lesion showing numerous, reddish, hard and soft pieces of tissue that ranged in size, having the average of 2x2x1.5 cm.


Photomicrograph of the excisional biopsy. . (
a) Photomicrograph of the excisional biopsy revealed extensive areas of cell-rich connective tissue stroma containing bands of osteoid matrix and anastomosing immature bone trabeculae (long arrows) (original magnification 40x).


Photomicrograph of the excisional biopsy. (
b) Scattered clusters of multinucleated giant cells (short arrows) (original magnification 40x).


Photomicrograph of the excisional biopsy. (
c) Plump osteoblasts can be seen surrounding the interconnecting immature bony trabeculae. Cellular osteoid (star) and some myxomatous areas (polygon) can also be detected (H&E stain, magnification 100x).


Chest CT images before . A; Lesions of the right lung before the initiation of erlotinib treatment.


After. Erlotinib treatment, and . B; Partial remission of lower lobe lesions of the right lung 1 month after the initiation of erlotinib treatment.


Before . C; Relapse of lower lobe lesions of the right lung with pachy shadows 4 months after the initiation of erlotinib.


After. The addition of sorafenib. D; Great mass in the lower lobe of the right lung with atelectasis, obstructive pneumonia and multiple patchy ground-glass opacities in the left lung 41 days after the addition of sorafenib.


The chest CT of patient one. (A-D): chest CT showing the nodes in the lungs and the local grid change in the right lower lobe.


The chest CT of patient one. (E-H): chest CT showing the pneumonitis 74 days after afatinib therapy, the pneumonitis manifested subpleural reticular shadow, ground glass and consolidation, and beehives, distributed in both lower lobe of both lungs. CT: computed tomography.


The episodes occurred in case 1.


The episodes occurred in case 2.


A 71-year-old man with right upper lobe T3N1M0 squamous cell carcinoma. (a) Axial computed tomography images in lung and soft-tissue windows showing an obstructive right hilar mass lesion with an endobronchial component at the origin of the right upper lobe bronchus (arrow).


A 71-year-old man with right upper lobe T3N1M0 squamous cell carcinoma. (b and c) Axial and coronal positron emission tomography/computed tomography images showing avid F-18 fluorodeoxyglucose uptake with the mass (arrow).


(a and b) Chest X-ray and coronal computed tomography reformation demonstrating the right pectoralis muscle flap (*) and Clagett window (arrow).


(c and d) Axial computed tomography images again showing the right pectoralis muscle flap (*) and Clagett window.


Bronchopleural fistula in a 71-year-old man after right pneumonectomy and Clagett window. (a and b) Axial computed tomography images in lung window demonstrating a fistula between the bronchial stump and pneumonectomy space with herniation of dressing material from the right pneumonectomy space through a fistula into the trachea and left mainstem bronchus (arrow).


High-resolution CT scan showing lung fibrosis.


O. P. G. Revealing bone loss from the alveolar ridge on the right side.


Excised specimen.


Post operative healing after 7 days.


Photomicrograph.


Intra oral growth.


Extra oral view.


Initial CT findings of left frontoparietal extra-axial hyperdensity and accompanying left-to-right shift of the ventricular system representing an acute SDH and its resultant mass effect.


With subsequent progression.


Following craniotomy and bone flap replacement there is recurrence (c).


After reoperation for craniectomy, ventricles assume a more midline position (d).


2 months postoperatively, the brain has a sunken appearance and residual postoperative fluid has disappeared (e).


Following cranioplasty the brain assumes its normal appearance (f).


A coronary angiogram demonstrating no signs of coronary atherosclerotic heart disease.


(A-C) Immunohistochemical staining CD45-positive showing peribronchial and intrabronchial wall leukocyte infiltrates.


Bone marrow eosinophilia. A representative Wright-Giemsa stain, (x400) of bone marrow aspirate smears from case 1. Notice the presence of various immature eosinophils, including eosinophilic band and Polymorphonuclear eosinophils.


Bone marrow eosinophilia. A representative Wright-Giemsa stain, (x400) of bone marrow aspirate smears from case 1. , as well as eosinophilic myelocyte and eosinophilic metamyelocyte.


The clinical course of case 1. The X axis indicate the time (days). AZA, azacitidine; WBC, white blood cells; PLS, prednisolone.


The clinical course of case 2. The X axis indicate the time (days). WBC, white blood cells; PLS, prednisolone.


Representative images of periodic acid methenamine silver staining (high magnification) of renal specimen from patient 2 showing duplication of the capillary wall consistent with membranoproliferative glomerulonephritis.


Platelet counts and treatment timeline.


Frontal view of fluoroscopic images during inguinal injection of Lipiodol. At abdominal level there is opacification of lymph vessels with drainage of Lipiodol into the cysterna chyli and thoracic duct (TD). Image of occlusion of the TD on the passage from abdominal to thoracic level. Black arrow: droplets of ethiodized oil at the passage from the inferior caval vein to the TCPC conduit, revealing early lymphovenous shunting. At thoracic level there is drainage of Lipiodol through multiple collaterals to hilar, peribronchial, mediastinal, and axillar dilated lymph vessels. Right mediastinum is more affected than the left.


Cone-beam computed tomography image during Lipiodol-based lymphangiography shows filling of several mediastinal abnormal dilated lymph vessels, predominantly peribronchial right (yellow arrows). This is similar to the fluoroscopic image of Figure 1.


Chest radiograph at presentation.


Computed tomography chest scan (axial view).


Chest radiograph on day 8 post right thoracotomy.


Repeat computed tomography chest scan showing intact splenic cyst and left effusion.


Chest radiograph 2 months post bilateral thoracotomy.


Timeline of the case after admission. (A-C) Time course of CK, myoglobin, plasma creatinine, and levels of uPCR and uACR.


Timeline of the case after admission. (D) Time of treatment regimens and kidney biopsy. CK, creatinine kinase; CYC, cyclophosphamide; uACR, urinary albumin-to-creatinine ratio; uPCR, urinary protein-to-creatinine ratio.


Histopathological findings in a kidney biopsy confirming pauci-immune crescentic GN. Representative photomicrographs of the kidney biopsy including staining for IgA (scale bar: 50 mum), IgG (scale bar: 50 mum), IgM (scale bar: 50 mum), C1q (scale bar: 50 mum), and C3c (scale bar: 50 mum); periodic acid-Schiff staining showing a glomerulus with crescent formation (scale bar: 50 mum); and hematoxylin/eosin staining with myoglobin casts (asterisks, scale bar: 100 mum) and tubulointerstitial inflammation with prominent eosinophilic infiltration (scale bar: 100 mum). C1q, complement component 1q; C3c, complement factor 3 conversion product; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; GN, glomerulonephritis.


Right eye shows conjunctival injection, corneal edema with infiltrates at the superior corneal incision site, membrane formation around the IOL and a 2 mm hypopyon. . Abbreviation: IOL, intraocular lens.


B-scan ultrasound of the right eye shows a significant amount of vitreous debris.


Intraoperative view during vitrectomy. . Notes: (A) Vitreous opacities and exudative membranes (red arrow) were removed by vitreous cutter.


Intraoperative view during vitrectomy. (B) Retinal hemorrhages were found in all quadrants.


Wide-field fundus photography of the right eye postoperatively demonstrates an attached retina under silicone oil tamponade and full panretinal photocoagulation treatment to all quadrants.


Chest radiography findings. Chest X-rays at 2 months before The chest radiograph was normal at 2 months before admission (A).


Chest radiography findings. And at admission The chest radiograph on admission (B) demonstrates symmetric multifocal consolidation and reticulonodular opacities in both lungs.


Chest radiography findings. Lung window . Axial lung window image (C) shows peribronchial ground-glass opacity (GGO), reticulation and consolidation in the periphery of both lungs. There was no significant endobronchial lesion and no axillary lymph node enlargement.


Chest radiography findings. Mediastinal window. On chest computed tomography on admission.


Chest X-ray on discharge.


At 6 months after discontinuation of steroid therapy Note the improvement in multifocal consolidation and reticulonodular opacities in both lungs on the chest radiograph on hospital discharge and no clinical deterioration at 6 months after discontinuation of the steroid therapy.


Patient's family tree.


Changes in end-tidal carbon dioxide and arterial oxygen saturation of pulse oxymetry after sugammadex administration. Event: (1) intravenous injection of sugammadex, (2) extubation, (3) disappearance of end-tidal carbon dioxide (EtCO2), (4) decline of arterial oxygen saturation, (5) start of continuous positive airway pressure.


(A) A chest enhanced computed tomography, demonstrating a filling defect in the left inferior pulmonary artery.


(B) Pulmonary angiography, showing a large filling defect in the left pulmonary artery.


(A) Diffuse sheets of cytotrophoblastic and syncytiotrophoblastic cells (H&E staining, x400).


(B) Tumor cells with diffuse positive cytoplasmic immunostaining for beta human chorionic gonadotropin (x100).


(C) Tumor cells with positivity for pan cytokeratin (x40).


CT abdomen showing intramural air (yellow arrow) within the proximal-mid stomach consistent with emphysematous gastritis.


CT abdomen/coronal view showing intramural air (yellow arrow) within the proximal-mid stomach consistent with emphysematous gastritis.


Illustration of the clinical course. . Note: Subjective overall physical functions, plasma monoamine metabolite levels (HVA [dopamine metabolite] level, total MHPG [noradrenaline metabolite] level, and free MHPG), and drugs administered to the 35-year-old man with paroxysmal kinesigenic dyskinesia (CBZ, ESC, APZ, and LOF). . Abbreviations: APZ, aripiprazole; CBZ, carbamazepine; ESC, escitalopram; HVA, homovanillic acid; LOF, loflazepate; MHPG, 3-methoxy-4-hydroxyphenylglycol; fMHPG; free MHPG, tMHPG; total MHPG.


Contrast-enhanced magnetic resonance imaging, T1-weighted fat saturated coronal image shows a large isointense signal intensity mass admixed with hyperintense signal intensity.


Immunohistochemistry - CD 31 - positive staining of atypical endothelial cells.


Head computed tomography images of a 64-year-old man with asymptomatic symptom for coronavirus disease 2019. (a) Axial showing subarachnoid space dilated associated with cortical atrophy (Red arrows).


Head computed tomography images of a 64-year-old man with asymptomatic symptom for coronavirus disease 2019. (b) Choroid plexus calcification in the lateral ventricles (Red arrows).


Chest computed tomography (CT) images of a 64-year- old man with asymptomatic symptom for coronavirus disease 2019. Axial plane chest CT scans showing lymph nodes larger than 1 cm (Red arrows).


Right temporal lobe biopsy. HE staining. Magnification is x40. Mildly hypercellular and gliotic gray matter with focal reactive changes. No neoplasia is seen.


A; The tumor lesion before crizotinib administration was mainly necrotic with air-fluid level and had a diameter of about 41 mm, ilo-perihilar right.


B; After 10 days of crizotinib administration, a CT scan of the chest showed extensive bilateral ground-glass opacities throughout both lungs and a further increase in the solid lesion (excavated), which measured about 60 mm.


C; After treatment with corticosteroid, a reduction of the ground-glass component occurred bilaterally, while the lesion in the right lower lobe appeared essentially unchanged in morphology and size.


Diffuse invasive aspergillosis observed in autopsy lung tissue (HE x400).


Cardiomegaly with dilated pulmonary arteries. Peripheral pruning of the lung fields also seen.


Tricuspid regurgitation of severe PH.


34-year-old woman with intermittent right flank pain diagnosed with genitourinary tuberculosis. Computed tomography (CT) shows heterogeneous enhancing mass involving the upper, and ,mid pole of the right kidney with aortocaval, and ,paracaval lymphadenopathy(arrow).


34-year-old woman with intermittent right flank pain diagnosed with genitourinary tuberculosis. Contrast enhanced CT scan of the abdomen show presence of rim enhancement with central necrosis in lymph nodes (arrow).


34-year-old woman with intermittent right flank pain diagnosed with genitourinary tuberculosis. Section removed during right side nephrectomy shows normal looking kidney (thin arrow and renal mass with pus around it (thick arrow).


34-year-old woman with intermittent right flank pain diagnosed with genitourinary tuberculosis. Histopathology slides. Stained with hematoxylin, and ,eosin (x100) shows presence of multiple granulomas (thick arrow).


34-year-old woman with intermittent right flank pain diagnosed with genitourinary tuberculosis. Stained with Ziehl-Neelsen stain (x100) shows presence of acid-fast bacilli (thin arrow).


(a) Computed tomography scan showing a mass suggestive of tumor near the sellar region.


(b) Magnetic resonance angiogram showing a large aneurysm of the left internal carotid artery (ICA).


(c) T2-weighted magnetic resonance image revealing the aneurysm extending to the suprasellar region.


(d) Cerebral digital subtraction angiogram of the left ICA revealing a giant aneurysm at the cavernous portion extending in the medial direction.


Time-series graphs of hormone load tests. Luteinizing hormone (LH)-releasing hormone load test: after intravenous injection of LH-releasing hormone (0.1 mg), LH and follicle-stimulating hormone (FSH) levels were examined. Thyrotropin-releasing hormone load test: after intravenous injection of thyrotropin-releasing hormone (0.5 mg), thyroid-stimulating hormone (TSH) and prolactin (PRL) levels were examined. Corticotropin-releasing hormone load test: after intravenous injection of corticotropin-releasing hormone (0.1 mg), adrenocorticotrophic hormone (ACTH) and cortisol levels were examined. Growth hormone (GH)-releasing factor load test: after intravenous injection of GH-releasing factor (0.1 mg), GH level was examined. Solid, dotted, and dashed lines indicate the data for preoperation, postoperation (3 weeks after operation), and 1 year after operation.


(a) Computed tomography scan on the day after the operation showing thrombosis of the aneurysm.


(b) Cerebral angiogram performed at 8 days after the operation demonstrating good patency of the bypasses and disappearance of flow to the aneurysm.


Magnetic resonance angiogram.


Image. Obtained at 8 years after the operation showing good patency of the radial artery graft and shrinkage of the aneurysm.


Generalized acne on the patient's face.


Wide purplish striae on the patient's abdomen.


Serial chest radiographs showing acute pulmonary oedema from her previous 4 admissions. Left pleural effusion with bat's wings appearance, and ,cardiomegaly.


Serial chest radiographs showing acute pulmonary oedema from her previous 4 admissions. Left pleural effusion with cardiomegaly.


Serial chest radiographs showing acute pulmonary oedema from her previous 4 admissions. Upper lobe diversion with bat's wings appearance, and ,cardiomegaly.


Serial chest radiographs showing acute pulmonary oedema from her previous 4 admissions. Left pleural effusion.


Lateral view of thoracolumbar X-ray showing the compression fracture at T9 to L1 spine with osteopenic bone.


Volumetric 3D reconstruction of the thoracolumbar spine from CT images showing compression fracture.


CT adrenal pre-contrast scan showing the right adrenal adenoma (blue arrow).


CT adrenal post-contrast scan showing the well-defined hypodense lesion at the medial limb of the right adrenal gland.


Chest radiographs obtained on day 3.


Medical image.


Computed tomography scans obtained at autopsy show that the lungs were completely infiltrated by effusion.


(A) Both lungs were massively congested.


(B) Numerous filamentous fungi are seen in the lung after Grocott staining (x400).


(A) The right pulmonary artery contained an embolus (arrow).


(B) Filamentous fungi (arrow) were detected in the embolus by Periodic acid-Schiff staining (x400).


H&E staining reveal large cells with cytoplasmic granules.


CT and angiographic evaluation. Nonenhanced head CT demonstrates acute hemorrhage within the frontal horns of the lateral ventricles.


CT and angiographic evaluation. And in the fourth ventricle Catheter cerebral angiography with a right internal carotid injection in the oblique view shows aneurysmal dilatation along the distal aspect (arrow) of a lenticulostriate artery (arrowheads) arising from the A1 segment of the right anterior cerebral artery (ACA).


CT and angiographic evaluation. Three-dimensional vessel reconstruction (d) clearly demonstrates the origin of the parent medial lenticulostriate vessel from the horizontal segment of the ACA with aneurysmal dilatation distally (arrow).


Chest radiography revealed consolidation in the right lower lung field at the initial visit.


Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


In an 18-year-old female at 15-week gestation, transabdominal ultrasonography (TAS) of pelvis (A-C) shows mildly enlarged, low lying, posteriorly placed placenta. Lower part of the placenta shows multiple anechoic cysts (arrows) which are extending inferiorly and covering the internal os.


On color Doppler imaging (D), low velocity signals were seen in the multicystic placental lesion.


TAS of the fetus showing no gross structural anomaly.


Development of a Right Pleural Effusion after Gemcitabine Treatment.


Images A-C Showing Echocardiographic Evidence of Pulmonary Hypertension.


Ethmoid sinus. Arrowheads). No apparent bony defect can be found.


High-resolution computed tomography (CT) reveals enlargement of the sella turcica . The broadly attenuated bony wall of both the sphenoid sinus. Arrowhead).


Preoperative magnetic resonance imaging depicts enlargement of the subarachnoid space. Arrowheads).


Dilated optic nerve sheaths. Arrow). This most likely indicates a chronic state of increased intracranial pressure.


Intraoperative photography shows the arachnoid herniation at the olfactory cleft (a).


After removing the mucosa surrounding the bony defect, the arrow heads indicate the edge of the osteodural defect (b).


Chest X-ray showing asymmetric lobar opacities.


Transthoracic echocardiography. (a) Four-chamber view showing a tricuspid annular plane systolic excursion of 16 mm.


Transthoracic echocardiography. (b) Four-chamber view showing a mildly dilated right ventricle, with a telediastolic basal diameter of 42 mm.


Computed tomography showing a prominent hilar pulmonary vasculature and pulmonary ground-glass opacities.


Esophagogastroduodenoscopy evidence of multiple hyperemic and hemorrhagic round-shaped lesions in distal duodenum.


Detail of duodenal lesions (PENTAX i-scan imaging).


Histopathology of gastric mucosa showing active inflammation (Hematoxylin and Eosin staining, 20x magnification).


Computed tomography manifestation and pleural fluid of the patient. Right-sided pleural effusion.


Computed tomography manifestation and pleural fluid of the patient. Haemorragic fluid aspirated from right pleural cavity.


Cytological examination of pleural fluid in the patient. Scattered clusters of endometrial glandular cells (ThinPrepTM, H&E stain, x400) in pleural fluid.


Cytological examination of pleural fluid in the patient. Showing nuclear positivity for. Estrogen receptor.


Cytological examination of pleural fluid in the patient. Progesterone receptor with immunohistochemical staining (conventional smear, x400).


Sagittal section magnetic resonance imaging image showing cystic lesion, extending from C2 to C3 level, anterior to the cord. Lesion is hypointense on T1-weighted images and hyperintense on T2-weighted images.


Axial section of T2-weighted image of magnetic resonance imaging showing hyperintense cystic lesion, lying anterior to the cord.


Histopathology slide showing pseudostratified columnar epithelium lined cystic cavity with few submucosal glands, suggestive of bronchogenic cyst.


Postoperative images in axial and sagittal sections of T2-weighted magnetic resonance imaging showing complete excision of the lesion, cerebrospinal fluid accumulation is seen in the intramuscular plane, posterior to the cord.


Coronal CT comparison before and after therapy: paranasal sinuses in coronal projection at T0: engagement of both maxillary sinuses, nasal cavities and ethmoid.


At T1: visible improvement of both maxillary sinuses, with almost complete patency of the nasal cavities and the ethmoid.


Pulmonary function testing with a bronchodilator revealing severe obstructive and restrictive failure without bronchodilator response.


Pulmonary ventilation and perfusion scintigraphy revealing a mosaic pattern of radio-isotope uptake decrease without ventilation-perfusion mismatch.


Bedside chest X ray showing diffuse and bilateral lung infiltrates, cephalization of the pulmonary vessels, bronchial wall thickening giving the aspect or railway track in the upper right lung field and blunting of the right costophrenic angle. The cardiac silhouette is not interpretable (not standing chest x ray).


(A-D) High Resolution Computed Tomography showing scattered ground glass opacities, with predominant bilateral postero-basal and central distribution. It is associated occasionally with a septal thickening giving the aspect of crazy paving.


Bedside chest X ray showing diffuse interstitial lung disease, affecting predominantly the right upper lobe. The right scissure is well visible. We remark also the blunting of the right costophrenic angle. The mediastinum is not interpretable.


(A-D) Computed Tomography Scan showing Crazy paving with ground glass opacities and bilateral thickening of the interlobular septa, located predominantly in the right upper lobe, the middle lobe and the basal segments of the right lower lobe, the apical segment of the left upper lobe and the upper segment of the left lower lobe.


Initial CT chest without contrast demonstrating left lower lobe infiltrate and pleural effusion. Right lower lobe showing patchy reticulonodular interstitial lung disease.


Transesophageal echocardiogram demonstrating small aortic valve vegetation (red arrow).


CT scans of both cases. A; In case 1, a focal patch of subpleural consolidation was observed after nivolumab re-administration.


CT scans of both cases. B; Pneumonitis gradually improved with corticosteroids.


CT scans of both cases. C; In case 2, diffuse ground glass opacity was observed in the lungs.


CT scans of both cases. D; Pneumonitis had clearly improved.


CT scans of both cases. E; Diffuse bilateral pneumonitis recurred in the lungs after nivolumab re-administration.


Operative findings. (a) The cyst arising from the third ventricle and protruding into the left foramen of Monro.


Operative findings. (b) A slight gap between the cyst wall and the edge of the foramen of Monro (black arrow).


Operative findings. (c) The cyst adhered to the choroid plexus at the edge of the foramen of Monro (black arrow).


Operative findings. D) The cyst decreased in size after surgery, confirming the bottom of the third ventricle.


Hematoxylin and eosin staining shows cuboidal epithelium lining with the collagen tissue, leading to the diagnosis of choroid plexus cyst.


Right supraclavicular adenopathy. A specimen of the right supraclavicular adenopathy by percutaneous biopsy.


Twelve-lead electrocardiogram on admission. The electrocardiogram demonstrates hyperacute T waves in V2-4.


Left coronary angiography. A; Initial left coronary angiography of cranial view revealing embolic obstruction straddling the bifurcation in the left anterior descending artery and diagonal branch (arrow).


Left coronary angiography. B; Left coronary angiography after aspiration showing the restoration of blood flow.


Contrast-enhanced computed tomography showed that tumor invading the left renal vein (arrow).


Transesophageal echocardiography showing a patent foramen ovale and shunt flow (arrow). LA: left atrium, RA: right atrium.


Transthoracic echocardiography on readmission showing right ventricular dilatation and a mobile mass attached to the tricuspid valve (arrow). RV: right ventricle, LV: left ventricle, RA: right atrium.


(a) MRI (diffusion-weighted image) showing right corona radiate infarction.


(b) MR angiography (MRA) reveals right middle cerebral artery (MCA) occlusion.


(c) Four hours after tPA administration, the right MCA was recanalized.


(b) Autopsy of the lung tissue (x20) (Case 3) showing inflammatory cell infiltrate of septae and extravasation of red blood cells into alveolar spaces.