H&E staining reveal large cells with cytoplasmic granules.


CT and angiographic evaluation. Nonenhanced head CT demonstrates acute hemorrhage within the frontal horns of the lateral ventricles.


CT and angiographic evaluation. And in the fourth ventricle Catheter cerebral angiography with a right internal carotid injection in the oblique view shows aneurysmal dilatation along the distal aspect (arrow) of a lenticulostriate artery (arrowheads) arising from the A1 segment of the right anterior cerebral artery (ACA).


CT and angiographic evaluation. Three-dimensional vessel reconstruction (d) clearly demonstrates the origin of the parent medial lenticulostriate vessel from the horizontal segment of the ACA with aneurysmal dilatation distally (arrow).


Chest radiography revealed consolidation in the right lower lung field at the initial visit.


Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


In an 18-year-old female at 15-week gestation, transabdominal ultrasonography (TAS) of pelvis (A-C) shows mildly enlarged, low lying, posteriorly placed placenta. Lower part of the placenta shows multiple anechoic cysts (arrows) which are extending inferiorly and covering the internal os.


On color Doppler imaging (D), low velocity signals were seen in the multicystic placental lesion.


TAS of the fetus showing no gross structural anomaly.


Development of a Right Pleural Effusion after Gemcitabine Treatment.


Images A-C Showing Echocardiographic Evidence of Pulmonary Hypertension.


Ethmoid sinus. Arrowheads). No apparent bony defect can be found.


High-resolution computed tomography (CT) reveals enlargement of the sella turcica . The broadly attenuated bony wall of both the sphenoid sinus. Arrowhead).


Preoperative magnetic resonance imaging depicts enlargement of the subarachnoid space. Arrowheads).


Dilated optic nerve sheaths. Arrow). This most likely indicates a chronic state of increased intracranial pressure.


Intraoperative photography shows the arachnoid herniation at the olfactory cleft (a).


After removing the mucosa surrounding the bony defect, the arrow heads indicate the edge of the osteodural defect (b).


Chest X-ray showing asymmetric lobar opacities.


Transthoracic echocardiography. (a) Four-chamber view showing a tricuspid annular plane systolic excursion of 16 mm.


Transthoracic echocardiography. (b) Four-chamber view showing a mildly dilated right ventricle, with a telediastolic basal diameter of 42 mm.


Computed tomography showing a prominent hilar pulmonary vasculature and pulmonary ground-glass opacities.


Esophagogastroduodenoscopy evidence of multiple hyperemic and hemorrhagic round-shaped lesions in distal duodenum.


Detail of duodenal lesions (PENTAX i-scan imaging).


Histopathology of gastric mucosa showing active inflammation (Hematoxylin and Eosin staining, 20x magnification).


Computed tomography manifestation and pleural fluid of the patient. Right-sided pleural effusion.


Computed tomography manifestation and pleural fluid of the patient. Haemorragic fluid aspirated from right pleural cavity.


Cytological examination of pleural fluid in the patient. Scattered clusters of endometrial glandular cells (ThinPrepTM, H&E stain, x400) in pleural fluid.


Cytological examination of pleural fluid in the patient. Showing nuclear positivity for. Estrogen receptor.


Cytological examination of pleural fluid in the patient. Progesterone receptor with immunohistochemical staining (conventional smear, x400).


Sagittal section magnetic resonance imaging image showing cystic lesion, extending from C2 to C3 level, anterior to the cord. Lesion is hypointense on T1-weighted images and hyperintense on T2-weighted images.


Axial section of T2-weighted image of magnetic resonance imaging showing hyperintense cystic lesion, lying anterior to the cord.


Histopathology slide showing pseudostratified columnar epithelium lined cystic cavity with few submucosal glands, suggestive of bronchogenic cyst.


Postoperative images in axial and sagittal sections of T2-weighted magnetic resonance imaging showing complete excision of the lesion, cerebrospinal fluid accumulation is seen in the intramuscular plane, posterior to the cord.


Coronal CT comparison before and after therapy: paranasal sinuses in coronal projection at T0: engagement of both maxillary sinuses, nasal cavities and ethmoid.


At T1: visible improvement of both maxillary sinuses, with almost complete patency of the nasal cavities and the ethmoid.


Pulmonary function testing with a bronchodilator revealing severe obstructive and restrictive failure without bronchodilator response.


Pulmonary ventilation and perfusion scintigraphy revealing a mosaic pattern of radio-isotope uptake decrease without ventilation-perfusion mismatch.


Bedside chest X ray showing diffuse and bilateral lung infiltrates, cephalization of the pulmonary vessels, bronchial wall thickening giving the aspect or railway track in the upper right lung field and blunting of the right costophrenic angle. The cardiac silhouette is not interpretable (not standing chest x ray).


(A-D) High Resolution Computed Tomography showing scattered ground glass opacities, with predominant bilateral postero-basal and central distribution. It is associated occasionally with a septal thickening giving the aspect of crazy paving.


Bedside chest X ray showing diffuse interstitial lung disease, affecting predominantly the right upper lobe. The right scissure is well visible. We remark also the blunting of the right costophrenic angle. The mediastinum is not interpretable.


(A-D) Computed Tomography Scan showing Crazy paving with ground glass opacities and bilateral thickening of the interlobular septa, located predominantly in the right upper lobe, the middle lobe and the basal segments of the right lower lobe, the apical segment of the left upper lobe and the upper segment of the left lower lobe.


Initial CT chest without contrast demonstrating left lower lobe infiltrate and pleural effusion. Right lower lobe showing patchy reticulonodular interstitial lung disease.


Transesophageal echocardiogram demonstrating small aortic valve vegetation (red arrow).


CT scans of both cases. A; In case 1, a focal patch of subpleural consolidation was observed after nivolumab re-administration.


CT scans of both cases. B; Pneumonitis gradually improved with corticosteroids.


CT scans of both cases. C; In case 2, diffuse ground glass opacity was observed in the lungs.


CT scans of both cases. D; Pneumonitis had clearly improved.


CT scans of both cases. E; Diffuse bilateral pneumonitis recurred in the lungs after nivolumab re-administration.


Operative findings. (a) The cyst arising from the third ventricle and protruding into the left foramen of Monro.


Operative findings. (b) A slight gap between the cyst wall and the edge of the foramen of Monro (black arrow).


Operative findings. (c) The cyst adhered to the choroid plexus at the edge of the foramen of Monro (black arrow).


Operative findings. D) The cyst decreased in size after surgery, confirming the bottom of the third ventricle.


Hematoxylin and eosin staining shows cuboidal epithelium lining with the collagen tissue, leading to the diagnosis of choroid plexus cyst.


Right supraclavicular adenopathy. A specimen of the right supraclavicular adenopathy by percutaneous biopsy.


Twelve-lead electrocardiogram on admission. The electrocardiogram demonstrates hyperacute T waves in V2-4.


Left coronary angiography. A; Initial left coronary angiography of cranial view revealing embolic obstruction straddling the bifurcation in the left anterior descending artery and diagonal branch (arrow).


Left coronary angiography. B; Left coronary angiography after aspiration showing the restoration of blood flow.


Contrast-enhanced computed tomography showed that tumor invading the left renal vein (arrow).


Transesophageal echocardiography showing a patent foramen ovale and shunt flow (arrow). LA: left atrium, RA: right atrium.


Transthoracic echocardiography on readmission showing right ventricular dilatation and a mobile mass attached to the tricuspid valve (arrow). RV: right ventricle, LV: left ventricle, RA: right atrium.


(a) MRI (diffusion-weighted image) showing right corona radiate infarction.


(b) MR angiography (MRA) reveals right middle cerebral artery (MCA) occlusion.


(c) Four hours after tPA administration, the right MCA was recanalized.


(b) Autopsy of the lung tissue (x20) (Case 3) showing inflammatory cell infiltrate of septae and extravasation of red blood cells into alveolar spaces.


Non-contrast head CT showing bilateral basal ganglia hemorrhages. (A) Hemorrhage volume was about 18 mL on the right and 27 mL on the left side.


Non-contrast head CT showing bilateral basal ganglia hemorrhages. (B) Markers applied to the patient's head before MIS to indicate puncture points and allow tracking. Hemorrhage volume was about 19 mL on the right and 29 mL on the left side.


Non-contrast head CT showing bilateral basal ganglia hemorrhages. (C, D) Immediate postoperative head CT scan showing a reduced hematoma volume. Hemorrhage volume was about 14 mL on the right and 11 mL on the left side.


Non-contrast head CT showing bilateral basal ganglia hemorrhages. (E, F) Postoperative day 3 CT scan showing residual clots (10 mL on the right and 2 mL on the left side).


Non-contrast head CT showing bilateral basal ganglia hemorrhages. (G, H) Postoperative day 19 CT scan showing that the intracranial hematoma was absorbed.


Chest computed tomography angiography of patient, arrow pointed the location of embolus in the
right main pulmonary artery.


Colonoscopy views of patient's sigmoid.


Rectum , arrow pointed to location of patchy ulceration compatible with inflammatory bowel disease.


EKG showing sinus rhythm with a rate of 78, T wave inversion in Lead 3 and V3.


CTPA showing bilateral subsegmental pulmonary embolism.


CTPA showing mild subsegmental pulmonary infarctions of the lower lobes.


At presentation.


Color fundus photograph of the right eye showed chorioretinal scar along the superotemporal arcade, deep creamy lesion inferior to the scar with bleb like subretinal fluid with macular involvement as demonstrated in the optical coherence tomography.


Medical image.


Two areas of early hypofluorescence at the choroidal level which persist in the end phase with surrounding hyperfluorescence on fundus fluorescein angiography more intense inferior to the superotemporal arcade which represent the choroidal ischemia, late indocyanine green angiography showed defined areas of hypofluorescence corresponding to a scar and recent choroidal ischemia.


Right groin showing multiple excavating ulcers, left groin shows 'Groove sign of Greenblatt' and multiple tense bullae with erosions over thighs and penile shaft.


Ultra-wide field color fundus photograph of the right and left eye depicting diffuse midperipheral chorioretinal atrophy with sparing of the central macula. . Note: The left eye also has central submacular fibrosis.


Fluorescein angiogram (FA) transiting the left eye reveals diffuse atrophy of the choriocapillaris sparing the central macula. . Notes: A central hyperfluorescent lesion in the early images stains (00:29) in the late angiographic images centrally (04:28) (arrowhead). Mild leakage is apparent nasally (arrow).


Microscopic finding of kidney biopsy with hematoxylin and eosin stain Periodic acid Schiff (PAS) stain, and Jones methionine silver (JMS) stain. . Notes: (A) Nodular sclerosis (big arrow) and thickened basement membrane (small arrow) - JMS.


Microscopic finding of kidney biopsy with hematoxylin and eosin stain Periodic acid Schiff (PAS) stain, and Jones methionine silver (JMS) stain. (B) Mesangial proliferation - PAS.


Microscopic finding of kidney biopsy with hematoxylin and eosin stain Periodic acid Schiff (PAS) stain, and Jones methionine silver (JMS) stain. (C) Neutrophil infiltration - PAS.


Microscopic finding of kidney biopsy with hematoxylin and eosin stain Periodic acid Schiff (PAS) stain, and Jones methionine silver (JMS) stain. (D) Cellular crescent.


Microscopic finding of kidney biopsy with hematoxylin and eosin stain Periodic acid Schiff (PAS) stain, and Jones methionine silver (JMS) stain. (E) RBC cast (arrow).


Microscopic finding of kidney biopsy with hematoxylin and eosin stain Periodic acid Schiff (PAS) stain, and Jones methionine silver (JMS) stain. (F) Focal acute tubular injury - JMS (arrow).


Microscopic finding of kidney biopsy with hematoxylin and eosin stain Periodic acid Schiff (PAS) stain, and Jones methionine silver (JMS) stain. (G) IF: C3 glomerulus.


Microscopic finding of kidney biopsy with hematoxylin and eosin stain Periodic acid Schiff (PAS) stain, and Jones methionine silver (JMS) stain. (H) IF: IgA glomerulus.


Chest and upper abdomen radiography showing dextrocardia, normal lungs fields and the stomach bubble under the right diaphragm.


Chest computed tomography showing dextrocardia, with no radiographic evidence of bronchiectasis.


Computed tomography scan of the abdomen showing liver on the left and spleen on the right.


Extraoral patient photograph. (column width).


Intraoral mass in right tonsillar and lateral pharyngeal wall (arrow) with yellow flecks on surface. (column width).


Sagittal section of MRI showing hyperintense mass (arrow) in nasal cavity, nasopharynx and oropharynx. (column width).


Coronal MRI section depicting hyperintense mass in right nasal cavity (red arrow) and fluid accumulation in right maxillary sinus (yellow arrow). (column width).


Excised fleshy, polypoidal gross specimen with both smooth and fungating warty surface. (column width).


Double walled sporangia surrounded by polymorphs and eosinophils (PAS stain, x10). (column width).


Fullness of the right neck at Level III.


Chromosome 10 array-CGH profile of the patient showing a 3.68 Mb deletion at 10pter and a 4.26 Mb deletion at 10qter. A comparison of the extension of the deletions with previously reported patients with ring chromosome 10 is also shown (white bars).


Oxygen pulse (VO2/HR) at the time of the diagnosis. x-axis: VO2; left y-axis: heart rate (HR) represented by red dots; right y-axis: VO2/HR represented by blue dots.


Oxygen pulse (VO2/HR) after cardiac therapy. x-axis: VO2; left y-axis: heart rate (HR) represented by red dots; right y-axis: VO2/HR represented by blue dots.


Arrows point to symblepharon formation seen inferiorly in the right.


Left. Eyes.


Limbal stem cell deficiency in the right.


Left. Eye. Arrows point to neovascularization and conjunctivalization of the cornea. Whorled keratopathy, obscured limbal architecture, subepithelial haze, and conjunctival hyperemia are also present bilaterally.


Image of the suction device with aspirated barium.


Chest X-ray revealing mild cardiomegaly, dilated right descending pulmonary artery, and oligemia in the right lung.


Dilation of right ventricle and pulmonary arteries (arrow).


Obstruction of pulmonary arteries from proximal portion (arrow).


Decrease in the right ventricle size (arrow).


Intrasellar and suprasellar expansive lesion with haemorrhage.


X-ray imaging showing fluid in pleural space, loss of pulmonary lobes volume and reticular opacification.


High-resolution computed tomography (HRCT): fluid in pleural cavity.


Interlobular septal thickening, mediastinal nodes enlargement.


The haematoxylin and eosin staining shows multiple emboli of atypical epithelial cells (A, B). Magnification of 0.5x.


The haematoxylin and eosin staining shows multiple emboli of atypical epithelial cells (A, B). , 20x.


The cells have a characteristic signet - ring shape with a central, optically clear droplet of cytoplasmic mucin and eccentrically displaced nucleus (C). , 40x.


Immunophenotyping of tumour cells: positivity for cytokeratin 7.


Cytokeratin 20.


Negativity for TTF1.


The biopsy was positive for mucin (D). Magnification of 10x.


The haematoxylin and eosin staining of signet ring cell gastric adenocarcinoma. Magnification of 20x.


MRI abdomen pelvis, T2 axial image, important pelvic cavity invasion with vesicular like lesions, englobing the uterus, the left iliac region with involvement of the posterior fascia of the left rectus abdominis muscle. .


Pathologic findings of growing teratoma (right bottom) in contact with the striated muscle of the rectus abdominis muscle (HES x50).


Swelling of the lower lip and chin after 1 hour of irrigation with sodium hypochlorite.


The edema spread to the sublingual and submental spaces and resulted in elevation of the tongue approximately 8 hours after the sodium hypochlorite accident. This required airway protection through oral intubation and mechanical ventilation.


A deep ulcer developed in the lower anterior buccal vestibule, in close proximity to the tooth being treated.


Clinical course of the patient. . Note: CAVI is affected by obstructive sleep apnea, blood glucose control, and body weight. . Abbreviations: CAVI, cardio-ankle vascular index; CPAP, continuous positive airway pressure; CABG, coronary artery bypass grafting; HbA1c, hemoglobin A1c.


Moderate degree of fiber size variation with increased endomysial and perimysial connective tissue. Intrafascicular and perivascular lymphoid aggregates are noted (a; HE). Higher magnification reveals hypertrophic vacuolated fibers.


Moderate degree of fiber size variation with increased endomysial and perimysial connective tissue. Scattered atrophic and necrotic fibers with intrafascicular lymphocytic infiltration are present (b; HE).


Moderate degree of fiber size variation with increased endomysial and perimysial connective tissue. Rimmed vacuoles are highlighted by mGT stain (c; mGT).


Moderate degree of fiber size variation with increased endomysial and perimysial connective tissue. Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles (d; bar = 1 mum).


Electropherogram of compound heterozygous mutations in this patient. A novel mutation c.1057A>G in exon 6 resulting in substitution of lysine to glutamic acid (p. K353E) is presented (a). A known mutation c.2086G>A in exon 12 resulting in substitution of valine to methionine (p.


Electropherogram of compound heterozygous mutations in this patient. A novel mutation c.1057A>G in exon 6 resulting in substitution of lysine to glutamic acid (p. V696M) is presented (b).


Initial orthopantomography.


Initial CT scan.


Right third molar surgery.


Suture.


Dentigerous cyst.


Upper third molar.


Follow-up orthopantomography.


Follow-up CT scan.


Chest CT scan of COVID-19 pneumonia (first chest CT scan). Axial sections of the chest CT scan at different levels show bilateral ground-glass opacities and consolidation images that are bilateral, subpleural, and located mainly in posterior regions (A-C).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). The chest CT scan performed 4 weeks after the management of severe COVID-19 pneumonia reveals the appearance of bronchiectasis. Green arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). The chest CT scan performed 4 weeks after the management of severe COVID-19 pneumonia reveals the appearance of bronchiectasis. Green arrow),. Fissure deformity. Orange arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Paracicatricial emphysema. Red arrow), and . Cavitation in the right middle lobe. Black arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Paracicatricial emphysema. Red arrow).


Follow-up chest CT scan of post-COVID-19 pneumonia (second chest CT scan). Subpleural reticulations. Blue arrow),. Lobular distortions. Violet arrow).


Post-corticotherapy chest CT scan (third chest CT scan). The chest CT scan performed after 3 months of corticotherapy of post-COVID-19 symptoms reveals the regression of ground-glass lesions and bronchiectasis, and the persistence of paracicatricial emphysema (A-C).


Post-corticotherapy chest CT scan (third chest CT scan). The chest CT scan performed after 3 months of corticotherapy of post-COVID-19 symptoms reveals the regression of ground-glass lesions and bronchiectasis, and the persistence of paracicatricial emphysema (A-C). (B-D) Show the disappearance of the cavity image of the right middle lobe, the regression of retraction signs, and the persistence of few reticulation lesions.


Post-corticotherapy chest CT scan (third chest CT scan). (B-D) Show the disappearance of the cavity image of the right middle lobe, the regression of retraction signs, and the persistence of few reticulation lesions.


Intraoperative transesophageal echocardiogram images with color flow doppler of the main pulmonary artery (MPA), left pulmonary artery (LPA) and right pulmonary artery (RPA) prior to surgical pulmonary embolectomy. The images reveal significant flow acceleration across a dilated MPA (Panel A) and minimal to no antegrade flow into the LPA (panel B) and RPA (panel C). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article. ).


Intraoperative transesophageal echocardiogram images with color flow doppler showing the main pulmonary artery (MPA), left pulmonary artery (LPA) and right pulmonary artery (RPA) after surgical pulmonary embolectomy. The images reveal reduced flow acceleration across the MPA (Panel A) and significantly improved flow in the LPA (Panel B) and RPA (Panel C). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article. ).


Intraoperative transesophageal echocardiogram images showing a significantly dilated right ventricle (Panel A) that normalized (Panel B) after surgical embolectomy.


(A,B) Clinical photographs of the patient showing swellings involving the whole of left thigh and anterior part of the left mid-shin.


(C) Radiograph of the pelvis showing a grossly deformed left femur and left ischium with multiple expansile lytic areas.


Bone scintigraphy image, anterior view showing increased tracer uptake involving the left ischium, femur and part of tibia at baseline.


Slightly reduced tracer uptake at the left femur when followed up at 6 months.


Bone scintigraphy image, posterior view showing increased tracer uptake involving the left ischium, femur, and part of tibia at baseline.


Expiratory high-resolution computed tomography (HRCT) revealed bilateral mosaic attenuation (arrows) consistent with air trapping.


Percent predicted forced expiratory volume in 1 second (%pred FEV1). percent predicted forced vital capacity (%pred FVC), and ratio of FEV1 to FVC expressed as a percent (%FEV1/FVC) for patient diagnosed with flavoring-related lung disease, August 2016 to July 2019.


CT scan of the neck showed right sided cervical adenopathy, heterogeneous thyroid and internal jugular vein thrombosis concomitant with superior thyroid vein thrombosis (white arrow).


Histopathological examination showed papillary thyroid carcinoma with papillaappearance and ground glass feature H and E x 40.


External photograph showing bilateral eyelid swelling and severe conjunctival injection.


External photograph showing macroscopically visible giant papillae in the right lower tarsal conjunctiva.


Fundus photographs of right (R) and left (L) eyes of a patient with transdermal methanol intoxication demonstrating bilateral optic atrophy.


Magnetic resonance imaging of a patient with transdermal methanol intoxication. Bilateral symmetric putaminal necrosis and generalized cortical atrophy are seen which is typical of methanol intoxication.


Gross findings of the pericardial sac.


Epicardium. During surgery. Multiple white nodules (arrows in A) and plaques (arrowheads in B) were identified on the surface of the thickened pericardial sac and the epicardium, respectively.


Ultrasonographic evaluation of disseminated neoplastic lesions on the pleura. Small nodules of 1-1.3 mm size on the surface of the pleura, exhibiting homogeneous low echogenicity inside with a hypoechoic structure, were identified, which had not been noted at the early stage of the disease, via detailed ultrasonographic examination using a high frequency linear probe (A, arrows).


Ultrasonographic evaluation of disseminated neoplastic lesions on the pleura. The adjacent normal pleurae were delineated as finely hyperechoic linear structures (B, arrowheads).


Ultrasonographic evaluation of disseminated neoplastic lesions on the pleura. The nodules gradually increased in size and number on the parietal pleura. Arrows) as well as the visceral pleura.


Ultrasonographic evaluation of disseminated neoplastic lesions on the pleura. Diaphragm. Arrows). Arrowheads, parietal pleura; TW, thoracic wall; PE, pleural effusion; DP, diaphragm; PL, lung; LIV, liver. Scale bar = 0.5 cm.


Preoperative magnetic resonance imaging scan.


Histopathological image.


Chest X-ray showing dextrocardia with normal lung field.


HRCT thorax showing bronchiectasis in the lingular segment.


X-ray of paranasal sinuses showing bilateral maxillary sinusitis with the absence of both frontal sinuses.


16-year-old girl with a swelling on the right-side of the face at the time of evaluation.


Axial CT image shows a radioopaque lesion occupyng most of the facial area in the mid and upper facial skeleton on the right side, which is significantly expanded. The maxillary sinus and nasal airway on the right are obliterated.


Axial CT image shows expansion of the right mandibular buccal cortical plate with radiopaque and radiolucent changes.


Axial CT image shows expansion of the right frontal and temporal bones.


PA view of skull shows diffuse radiopacity with faint, linear to irregular central opacities.


14-year-old girl with swelling on the left-side of the face at the time of evaluation.


Inside of the mouth shows intraoral swelling in the region of the palate, labial, and buccal sulcus region.


Panoramic radiograph of the patient shows radiopacity and displacement of teeth.


Coronal CT shows obliteration of left maxillary sinus and displacement of teeth.


Brain MRI finding. Patient 1, (A,B) Axial T2-weighted and fluid attenuated inversion recovery (FLAIR) MR image reveals hyperintense lesion in pons.


Brain MRI finding. (C) No abnormal signal in the parietal and occipital lobes was found.


Brain MRI finding. (D,E) Follow-up MRI at 1 month shows complete resolution of the hyperintensity in the brainstem.


Chest X-ray showing two large nodular opacities along the right heart border.


Axial computed tomography of the thorax (mediastinal window) revealed heterogenous enhancing lobulated mass in superior mediastinum compressing and occluding the superior vena cava.


Axial computed tomography of the thorax.


Lung window. Mediastinal window showing a right middle lobe bronchus cutoff sign due to a moderately enhancing mass. Pleural and pericardial deposits along with right pleural effusion are also seen.


Axial computed tomography of the thorax (mediastinal window) showing metastatic mediastinal lymphadenopathy which is encasing the right pulmonary aorta.


(a and b) Axial computed tomography (arterial phase) showing a wedge-shaped intensly enhancing area in segment IV A.


Modified apical 4 chamber view TTE showing a 2.4 cm x 2.4 cm pedunculated myxoma in the right atrium (RA) attached to RA free wall extending to interatrial septum.


Modified apical 4 chamber view TTE showing 1.1 cm x 1.1 cm pedunculated myxoma attached to the septal leaflet of the tricuspid valve.


CW Doppler across the tricuspid valve showing severe high-pressure TR with 60 mmHg gradient.


TTE basal short axis view showing dilated RVOT, pulmonary artery and heterogenous pedunculated right atrium mass with calcium specks attached to RA free wall.


High-resolution computed tomography of the thorax showing embolic fragment in the lateral aspect of right pulmonary artery (PA), and ,medial aspect of left PA.


High-resolution computed tomography thorax showing pulmonary infarct in left lung field.


- Complete opacification of the right hemithorax. Note obliteration of ipsilateral main bronchus and foci of perihilar alveolar opacity on the left lung.


- Axial computed tomography (CT) of the chest - mediastinal window - showing voluminous hypodense collection with discrete pleural thickening and enhancement associated with retraction of the apex of the right hemithorax.


Axial CT of the chest - pulmonary window. A and B - Fissure thickening with micronodules. Septal thickening and ground glass opacities associated with septal thickening ("crazy paving") in the left upper lobe.


Gross examination of right lung showing pleural thickening, adherence to diaphragm, and ,pneumonia-like pattern.


Photomicrography of tumor cells filling alveolar spaces (air dissemination) (H&E 200x).


Photomicrography of tumor lymphatic dissemination, note fluid edema in bronchiolar lumen (right bottom) (H&E 200x).


Photomicrography of segmental bronchus invaded and obliterated by tumor (H&E original magnification 12.5x).


Photomicrographs. Acinar pattern with columnar cells (H&E 400x).


Photomicrographs. Solid pattern with mucin vacuoles (H&E 400x).


Photomicrographs. Signet-ring cells (H&E 400x).


Photomicrographs. Sheet-like pattern of poorly cohesive cells with eosinophilic cytoplasm (H&E 400x).


Photomicrographs. Large eosinophilic cells in focal trabecular pattern (H&E 400x).


Photomicrographs. Clear cells (H&E 400x).


Photomicrographs. Eosinophilic globules (H&E 400x).


Photomicrographs. Large nuclear pseudoinclusion (arrow) (H&E 400x).


Photomicrographs. Immunohistochemistry for keratin 7 (H&E 400x).


Photomicrographs. Focal nuclear TTF-1 immunostaining (H&E 400x).


Photomicrographs. Focal keratinization (H&E 400x).


Photomicrographs. Focal immunostaining for keratin 5/6 (H&E 400x).


Photomicrographs. Immunohistochemistry for CEA with diffuse staining (H&E 100x).


Photomicrographs. Multifocal immunostaining for AFP (H&E 400x).


Photomicrographs. Diffuse Hep-par (H&E 400x).


Photomicrographs. Cytoplasmatic granular TTF-1 staining (H&E 400x).


Pre-treatment computed tomography (CT) image with intravenous (IV) contrast, demonstrating bilateral pleural effusions (white arrows) and moderate-sized pericardial effusion (black arrows), prior to thoracentesis, pericardiocentesis, or chemotherapy. Black asterisk = atelectatic lung.


Post-treatment CT image after two cycles of fludarabine and cytarabine and four cycles of decitabine alone. White arrow = residual small right pleural effusion. No left pleural effusion or pericardial effusion. White asterisk = liver.


Chest x-ray, posteroanterior (PA) view, January 2019: Bilateral peri-hilar, peri-bronchial cuffing with diffuse, bilateral alveolar shadows more in the right lung.


Chest x-ray PA, April 2020: showing left upper lobe mass-like opacity.


CT chest, April 2020: lung and mediastinal windows respectively, showing a lobulated mass-like lesion.


Chest x-ray PA, March 2021: the left upper lobe opacity resolved.


March 2017, CT chest, lung window, showing bilateral bronchial wall thickening and atelectatic bands in the right upper lobe.


CT chest (mediastinal window), January 2019: there is multiple mediastinal enlarged lymph nodes.


Chest x-ray, PA view, December 2020: normal chest x-ray.


Chest x-ray PA, February 2018: Bilateral, perihilar, peribronchial cuffing with diffuse bilateral alveolar shadows more in the right lung.


CT chest - lung window, February 2018: bilateral ground-glass opacities with bilateral bronchial wall thickening of both upper lobes and basal segments of the right lower lobe.


Chest x-ray PA, February 2021: normal.


Immediate postoperative chest AP radiograph shows increased opacity in bilateral perihilar areas.


Postoperative electrocardiogram shows ST segment elevation in leads V2-4 and T-wave inversion in leads I, aVL, V2-6.


CT scan of chest showing bilateral diffuse ground glass opacity of lung parenchyma on presentation.


CT scan of chest showing improved opacity of lung parenchyma 2 weeks after discontinuation of daptomycin.


Computed tomography (CT) of chest showing a filling defect in the right upper labor pulmonary artery extending into the segmental and subsegmental pulmonary branches consistent with an acute pulmonary embolism (yellow arrowhead). Patchy infiltrates are indicated by the red arrowhead.


Platelet count and time points for anticoagulation administration and laboratory testing.


(A,B) TC and LDL-C levels in response to therapy. N, no; Y, yes.


Axial CT scan. Extensive subcutaneous presence of air in the right palpebra.


Coronal CT scan. Disruption of the right lamina papyracea. Presence of air at the roof of the orbit.


Axial CT scan. One month after the trauma. Complete resolution of air in the right palpebra.


Echocardiography and CTPA images of the patient. . Notes:. Echocardiography demonstrated severe tricuspid valve regurgitation with an estimated right ventricular systolic pressure of 103 mmHg.


Echocardiography and CTPA images of the patient. Computed tomography pulmonary angiogram showed filling defect of the pulmonary artery, and there was no tumor in the lung field. . Abbreviation: CTPA, computed tomography pulmonary angiogram.


Histopathologic examination and immunohistochemistry staining of tumor cells. . Notes: Histopathologic examination of the tumor showed spindle cells with nuclear pleomorphism, arranged in fascicles and with massive necrosis (A) (hematoxylin and eosin staining; magnification: 200x).


Histopathologic examination and immunohistochemistry staining of tumor cells. Immunohistochemistry staining showed that the tumor cells were positive for VIM.


Histopathologic examination and immunohistochemistry staining of tumor cells. SMA.


Histopathologic examination and immunohistochemistry staining of tumor cells. Ki-67.


Histopathologic examination and immunohistochemistry staining of tumor cells. CD99.


Histopathologic examination and immunohistochemistry staining of tumor cells. But negative for DES. (magnification: 200x).


Images of the tumors. . Notes:. 18F-fluorodeoxyglucose uptake on positron emission CT showed accumulated radioactivity in middle, and ,lower chest, and ,no other hypermetabolic lesions were observed elsewhere.


Images of the tumors. CT pulmonary angiogram showed filling defect of the right pulmonary artery.


Images of the tumors. Contrast-enhanced CT detected a right adrenal gland tumor after radioactive seed implantation.


Images of the tumors. Contrast-enhanced CT detected a mass in the right hilum and pleural effusion. . Abbreviation: CT, computed tomography.


(A) Chest radiograph posteroanterior view showing a right midzone patchy consolidation and an ill-defined opacity abutting the right cardiac border with loss of cardiac silhouette.


(B) Chest radiograph right lateral view showing a wedge shaped density extending from the hilum anteriorly and inferiorly along with loss of volume confirming a middle lobe syndrome.


(A) High resolution computed tomography (HRCT) (mediastinal window) of the thorax showing middle lobe syndrome.


(B) HRCT (lung window) of the thorax showing central bronchiectasis.


Matted lymph nodes in the right inguinal region. Discharging sinus and healed scars on the left side.


Mantoux test showing highly positive reaction with induration measuring 25 mm.


Complete resolution of bilateral buboes with antituberculous treatment.


Images obtained a week after the operation. A T2-weighted axial MR image. B; Arrow indicates that satisfactory CSF flow through aqueduct of Sylvius is detected. Indicates the fenestrations of the apical membrane (f1 and f2).


Images obtained a week after the operation. A T2-weighted axial MR image. C;. Indicates two fenestrations of the basal cyst membrane behind the midline (f3 and f4).


Standard chest X-ray on admission.


Lung biopsy showing increased interstitial collagen blue), elastic fibers (a gray), activated pneumocytes ( ), and pathological vessels with thickened walls. 100x.


Lung biopsy with increased interstitial collagen (red) and elastic fibers (blue), Activated pneumocytes , Pathologic vessels with thick walls. evaluation of vessel invasion, 100x.


Lung biopsy with interstitial fibrosis. and activated pneumocytes. Hematoxylin and eosin, 100x.


Right sided pulmonary artery angiography performed at Giessen indicating chronic thromboembolic pulmonary hypertension which was also demonstrated by two ventilation/perfusion (V/Q) mismatches.


Echocardiography images (Two-chamber long axis). Acute onset.


Echocardiography images (Two-chamber long axis). End-diastole.


End-systole. Two months later.


Coronary angiography.


Left coronary. Right coronary. There is no epicardial coronary stenosis.


Tc99 MIBI-SPECT images. Early images (a, c) show decreased myocardial perfusion in distal anterior and lateral wall, and apex.


Tc99 MIBI-SPECT images. (b, d) after complete recovery.


Bull-eye and thickening images. (a-c) Acute once.


Bull-eye and thickening images. (a-c) Acute once. (b-d) Two months later.


Bull-eye and thickening images. (b-d) Two months later.


Gated-SPECT. Synchronism, (a) Acute onset.


Gated-SPECT. (b) Two months later.


Twelve lead electrocardiogram showing the anterior precordial ST depression, S1Q3T3 pattern, ST segment depression in inferior leads and R/S in V6 <1.


Echocardiography demonstrating tricuspid regurgitation and an estimated RV systolic pressure of approximately 80 mmHg.


The 64-slice spiral computed tomography image demonstrating thrombotic obstruction of segmental and subsegmental left and right branch pulmonary arteries.


Blood work on the day of admission and blood work on the last day of hospitalization.


Anesthetic chart. Double circle marks represent start/end of surgery; cross marks represent start/end of anesthesia; a triangle mark represents endtracheal intubation.


Preoperative audiogram. A severe mixed sensory and conductive hearing loss is observed on the right ear, and an air-bone gap is present at low frequencies.


Preoperative CT scan. Air bubbles (arrow) are visible in the vestibule.


Illustration depicting the anomalous stapes footplate. The arrow illustrates the bony defect, while the arrowhead illustrates a tear in the membranous stapes footplate.


Postoperative audiogram. The 1-month postoperative audiogram had thresholds somewhat improved compared to the preoperative audiogram.


Right periorbital swelling and ptosis, and severe chemosis were observed in the initial presentation.


Non-contrast orbital CT scan revealed periorbital tissue infiltration and right orbital edema (arrows). A; Axial view shows muscular thickening of the right lateral rectus muscle.


Non-contrast orbital CT scan revealed periorbital tissue infiltration and right orbital edema (arrows). B; Coronal view shows right periorbital swelling and mucoperiosteal soft tissue attenuation in the left maxillary sinus.


Right lid swelling, chemosis, corneal edema, and orbital inflammation resolved 2 weeks after the onset.


Paranasal computed tomography images before treatment. Pretreatment computed tomography at 8 years and 6 months of age shows paranasal sinusitis. The scans reveal secretory reservoirs in the frontal, maxillary, ethmoid, and butterfly paranasal sinuses.


Endoscopic images of the bilateral nasal cavity and histological analysis of the nasal polyps. A; The endoscopic images show polyps in the bilateral nasal cavity.


Endoscopic images of the bilateral nasal cavity and histological analysis of the nasal polyps. B; Histological analysis shows numerous eosinophils in the polyps. Hematoxylin and eosin staining x200. All paranasal sinuses were released, but after 4 months later, the nasal polyps recurred.


Growth curve of the patient height and weight. The effects of oral steroids suppressed the patient height growth and gained weight. His growth has been restored as the symptoms improved with the administration of omalizumab and he was able to lose weight on oral steroids. B. Ht. And B. Wt. Indicate body height, and body weight, respectively.


Clinical course and laboratory findings. A timeline of the treatments, symptoms, IgE levels, eosinophil counts, and %FEV1.0 is presented. PSL prednisolone, ICS/LABA inhaled long-acting beta-agonist/corticosteroid, CsA cyclosporine, BIS budesonide inhalation suspension, FP fluticasone propionate, SLM salmeterol xinafoate, ESS endoscopic sinus surgery.


Chest X-ray showing massive left side pleural effusion and right upper zone nodular opacity (small air pocket in left apex is due to previous aspiration).


Cytological examination of the pleural fluid showing numerous atypical plasma cells with binucleate forms and plasmablasts.


(a) Computed tomography scan of the chest with contrast showing bilateral effusion with pleural infiltration, right upper lobe involvement, soft tissue lesion in the posterior mediastinum.


(b) Computed tomography scan of the abdomen showing lytic lesions in pelvis and sacrum.


Bone marrow biopsy showing extensive replacement of marrow by sheets of atypical plasma cells, with binucleate and plasmablasts.


Bronchial arterial angiography shows the absence of bleeding event.


Chest X-ray. (A) The chest X-ray shows total atelectasis of left lung after concluding the embolization of bilateral bronchial artery. There was no evidence of active bleeding, but blood clot was detected and removed using bronchoscope.


Chest X-ray. (B) After the removal of blood clot, an improvement in lung collapse was observed.


Flexible bronchoscope through the supraglottic device with bronchial thermoplasty catheter (white in color).


Bronchoscopic view of thermoplasty catheter in right lower lobe of bronchus.


Multiplanar computerized reconstruction of cardiac computerized tomography angiogram showed the left innominate vein drain into the right superior vena cava which in turn drain to the posterior left atrium.


Antero-posterior and lateral views of angiograms; after dye injection in a peripheral vein in the left arm. It showed that the left inomminate vein drain into the right superior vena cava which in turn drain to the posterior left atrium.


Intraoperative findings:. Dorsal view.


Ventral view. CB, common right upper and middle lobe bronchi; ML, middle lobe; RLB, right lower bronchus; RMB, right main bronchus; RPA, right pulmonary artery; RUL, right upper lobe; SL, stapling lines.


A; Sagittal computed tomography angiography showing a left cerebellar hemisphere hemorrhage.


B; Thrombin generation curves obtained with 5pM tissue factor and 4 muM phospholipids (final concentration) in platelet-poor plasma using calibrated automated thrombin generation assay (Stago, Asnieres, France). The area under the thrombin generation curve (or endogenous thrombin potential) is significantly higher in the patient (red) compared to another subject with afibrinogenemia (blue) or a representative normal control (grey). In this patient with combined inherited antithrombin and fibrinogen deficiency, increased thrombin generation is due to insufficient inhibition of thrombin. Thrombin generation is decreased after infusion of 30 U/kg antithrombin concentrate (pink).


C; Visualization of the left coronary artery with computed tomography coronary angiogram showing 80% stenosis in the common trunk.


D; Visualization of the left coronary artery with computed tomography coronary angiogram showing 50% stenosis in the anterior interventricular branch of left coronary artery.


(a) Chest X Ray showing "white out lung.


(b) CT showing dense calcific fibrosis and subpleural cyst.


(a) Lung explant with granular external surface.


(b) Cut surface with granular appearance.


99mTc-sestamibi dual phase images showing a 4-gland parathyroid hyperplasia. . (a) Tracer uptake by the thyroid and parathyroid glands in the early phase image.


99mTc-sestamibi dual phase images showing a 4-gland parathyroid hyperplasia. . (b) Delated tracer washout from all the hyperplastic parathyroid glands (the arrows), in the late phase image.


Changes in Serum Calcium and PTH postoperatively. . Serum Ca: total serum calcium; Ca2: serum ionized calcium level; PTH: Parathyroid hormone.


Changes in Electrolytes (Phosphorus and Magnesium) Postoperatively.


Extensive intravascular filling defects of bilateral pulmonary arteries (red arrows).


The right ventricular (RV) cavity dilation with a thickened wall. The distorted interventricular septum (IVS) is pushed toward the left ventricular (LV) cavity.


The markedly congested lungs. A lobulated, pale, yellow mass is occupying the entire volume of the right and left main pulmonary arteries, loosely adherent to the pulmonary artery at multiple locations and measuring 13 cm in greatest dimension. The pulmonary artery mass extended into the parenchyma of the right upper lobe, 6 cm in greatest dimension.


The cells are positive for desmin and vimentin and showed focal reactivity for actin. This is consistent with a high-grade primary pulmonary artery leiomyosarcoma.


(a) Lymphoid infiltrate in BMA. (b) Lymphoid infiltrate in BMB (H and E, 40x).


Brain MRIs of the patient revealed the size of BM lesion and PTBE. Comparing with the brain MRI before, the maximum vertical diameter of BM demonstrated slight shrunk (17x22 to 14x18 mm).


Brain MRIs of the patient revealed the size of BM lesion and PTBE. (15x17 to 12x9 mm). While peritumoral brain edema shrunk significantly.


Mobile chest X-ray displaying oligemic lung fields.


Computerized tomography pulmonary angiogram (arterial phase, axial slice) demonstrating persisting pulmonary embolus in a branch of the left pulmonary artery (arrow).


Initial chest x-ray after onset of symptoms showing peribronchial vascular opacities in the left lung base and left perihilar region.


Chest x-ray 48 h after stopping clozapine (the second time) showing markedly improved lungs fields now almost completely clear.


An acute papulovesicular rash of both legs.


Rapidly evolved into palpable purpura and hemorrhagic-bullous lesions of variable size ranging from 5 to 40 mm.


Hemorrhagic bullae developed on both feet an lower legs (a-c). A deep necrosis resulting from a large blister at the dorsum of the right feet evolved (a,b) neccessitating autologous skin transplantation.


Hemorrhagic bullae developed on both feet an lower legs (a-c).


Re-examination 11 months after disease onset showed complete clinical remission of disease with re-epithelialization of affected areas (d-f).


Contrast enhanced computed tomography revealing Crazy paving patterned diffuse ground glass attenuation with inter/intralobular septal thickening, representing diffuse alveolar damage, both lungs (black arrow).


Histology of the left lung, pulmonary alveolar proteinosis high magnification photomicrograph showing complete filling of alveoli with periodic-acid-Schiff-positive granular material in preserved alveolar architecture (black arrow) (PAS, x400).


USG showing calcium deposition.


Renal biopsy showing Calcium deposition in medulla.


D-e Myelography. D-e The arrows show the contrast agents leaking from the subarachnoid space to the thorax.


(A) Pre-operative video-endoscopic evaluation showing salivary penetration into the larynx and a wide pharyngeal space.


(B) Postoperative video-endoscopic evaluation showing absence of saliva residue and a decrease in vallecula residue due to a shortened distance between the epiglottis and the base of the tongue, as well as a narrowing of the space of the vallecula.


(A) Placement of the two skin incisions used for the minimally invasive laryngeal suspension, a 2-cm incision at the revel of the mandible and a second 3-cm incision between the hyoid bone and the superior border of the thyroid cartilage. A 1-cm skin incision is also performed for tracheostomy.


(B) Three holes, each separated by 1 cm, are created in the mandible and 6, each separated by less than 1 cm, in the thyroid cartilage. The mandibular and the thyroid cartilage were closely fixed using No.2 nylon thread, passed through the subcutaneous tunnel on the hyoid bone.


Chest computed tomography (CT) scan before treatment (A) shows multiple bilateral areas of consolidation with surrounding ground glass opacities; there are scattered pulmonary nodules, some of which are cavitated.


CT acquired after 2-month treatment (B) shows marked improvement.


T2-flair MRI reveal increase of signal intensity in the right pontomesencephalic junction and left cerebellar hemisphere.


Angio-MRI showing a left vertebral artery dissection in V4 segment.


Chest computed tomography (CT) findings showing evidence of a tumor response. Chest CT images showed a tumor response prior to and after the patient received icotinib. (A) The first appearance of a nodule on August 12, 2010, at four months post-kidney transplant.


Chest computed tomography (CT) findings showing evidence of a tumor response. Chest CT images showed a tumor response prior to and after the patient received icotinib. (B) On February 9, 2011, the nodule remained stable as previously.


Chest computed tomography (CT) findings showing evidence of a tumor response. Chest CT images showed a tumor response prior to and after the patient received icotinib. (C) On October 13, 2011, CT imaging showed a marginal increase in the size of the nodule.


Chest computed tomography (CT) findings showing evidence of a tumor response. Chest CT images showed a tumor response prior to and after the patient received icotinib. (D) On February 15, 2012 (prior to treatment with icotinib), the nodule was pathologically diagnosed as adenocarcinoma.


Chest computed tomography (CT) findings showing evidence of a tumor response. Chest CT images showed a tumor response prior to and after the patient received icotinib. (E) Imaging results on March 12, 2012, following one week of treatment with icotinib.


Chest computed tomography (CT) findings showing evidence of a tumor response. Chest CT images showed a tumor response prior to and after the patient received icotinib. (F) Imaging results on August 7, 2012, following five months of treatment with icotinib. The patient met the Response Evaluation Criteria in Solid Tumors (RECIST) for a partial response. The arrows indicate the tumor site.


Serum tumor markers prior to and following icotinib treatment. Serum. Carcinoembryonic antigen (CEA).


Serum tumor markers prior to and following icotinib treatment. CA19-9 levels decreased following treatment with icotinib.


Computed tomography (CT) evidence of interstitial pneumonitis. (A) On October 13, 2011, the CT image showed for the first time scattered, patchy shadows in the two lower lobes of the lung.


Computed tomography (CT) evidence of interstitial pneumonitis. (B) On February 15, 2012, no shadows were detected.


Computed tomography (CT) evidence of interstitial pneumonitis. (C) CT findings on May 12, 2012, three months after the start of icotinib.


Computed tomography (CT) evidence of interstitial pneumonitis. (D) CT findings on August 7, 2012, five months after the start of icotinib.


Computed tomography (CT) evidence of interstitial pneumonitis. (E) CT findings on October 15, 2012, two months after the patient discontinued rapamycin and icotinib.


Computed tomography (CT) evidence of interstitial pneumonitis. (F) CT findings on November 10, 2012, one month after the patient underwent a segmentectomy. The arrows indicate the site of the interstitial lung disease.


Plasma concentration of icotinib. Eight time points (0, 0.5, 3, 6, 8, 11, 16 and 24 h post-dose) were selected to determine the plasma concentration of icotinib (125 mg TID) by high-performance liquid chromatography tandem mass spectrometry. The resulting plasma concentration time profile was similar to that in the published phase I trial of icotinib.


Clinical characteristics of our patient. Chest CT showed disclosed extensive progressive interstitial changes in both lungs on August 2016.


(A) The "milky" bronchoalveolar lavage fluid.


(B)
P. Jirovecii was detected in the bronchoalveolar lavage fluid by silver hexamine staining.


(A) Pathology showed large amounts of PAS-positive lipoproteins in alveolar and bronchial cavities (x100).


(B) Pathology showed large amounts of D-PAS-positive fine granular lipoproteins in alveolar and bronchial cavities (x100).


Chest CT showed significant improvement in both lungs on August 2018.


Plain radiography. A; A ground-glass appearance with marked calcification and a pathological minor fracture in the right proximal femur.


Plain radiography. B; Multiple ground-glass appearances in the skull.


MRI. A; Isointensity with punctate low signal intensity on T1-weighted images.


B; Irregular high signal intensity on T2-weighted images.


C; Irregular peripheral predominant enhancement on Gd contrast-enhanced images.


Bone scintigraphy showing an accumulation of radioactivity in the right ilium, right proximal femur, right proximal ulna, and the skull.


A; Pathological fracture with displacement in the metaphysis of the right femur.


B; Artificial bone was implanted after curettage and fixed with a locking plate so that the varus of the proximal femur was corrected.


Histopathological findings of the specimen. A; Nodular hyaline cartilage tissue is present in the majority of the specimen without marked atypia.


Histopathological findings of the specimen. B; Proliferation of fibroblast-like spindle cells and woven bone were evident in parts of the lesion.


During Rem sleep, an excessive amount of tonic chin electromyogram activations was evident.


Complex behaviors were detected during N3 sleep through video. The specific movements are as follows: he suddenly sat up from N3 sleep stage with eyes opened widely, shouted, and aimlessly moved his limbs. (A-F) Indicates the order in which abnormal actions occur.


The patient's heart rate rapidly increased from 60 to 105 beats/min with the increase in breathing rate. Brain wave changes from delta to alpha wave.


Still images from patient's transthoracic echocardiogram showing. No early shunting with saline bubble (identified by yellow arrows) injection.


Followed by. Late passage of bubbles (identified by red arrows) into the Left Atrium and Ventricle representing Intrapulmonary Shunting.


Tooth in the right bronchus intermedius as seen on chest X-ray.


Coronal CT with the aspirated tooth in rat bronchus intermedius.


Rat tooth forceps.


The aspirated tooth removed by rat tooth forceps.


External genitalia showing empty right hemiscrotum with meatal opening at penoscrotal junction (arrow mark pointing the urinary meatus).


(a-c) Contrast-enhanced computed tomography abdomen and pelvis showing large complex cyst in the left side of the pelvis and rectovesical space.


(a) Intraoperative picture showing dense adhesion between cyst, bladder, and left spermatic cord.


(b) Resected specimen (cystic structure resembling uterus, cervix with cord structure, and left testis).


(a) Excised gross specimen.


(b) Histopathology showing poorly formed areas of endometrial glands and stroma.


(c) Histopathology showing foci of the cervix.


(d) Histopathology showing seminiferous tubules with spermatocytes and spermatogonia.


Removal of huge clot (black arrow) from left ventricle, curve lines depict edges of ventriculotomy.


Echocardiography shows huge clot in left ventricle (surrounded by curve lines).


Left ventricular apex and internal wall of left ventricle after removal of clot.


Color photographs (a, b) show bilateral asymmetric irregular diffuse hypopigmented macular changes associated with focal hyperpigmented areas.


A radial pattern of hyperautofluorescence was seen in the short-wavelength fundus autofluorescent images (c, d), consistent with butterfly-shaped macular pattern dystrophy. These lesions were associated with hypoautofluorescent patches corresponding to the areas of RPE hypertrophy.


Radiological features during follow-up. (A-C) CT images showing a NSIP + OP pattern and reticular and ground-glass opacities along the bronchovascular bundles with patchy air space consolidation before prednisone treatment. (A) The first chest CT scan at the age of 3 months.


Radiological features during follow-up. (A-C) CT images showing a NSIP + OP pattern and reticular and ground-glass opacities along the bronchovascular bundles with patchy air space consolidation before prednisone treatment. (B) The subsequent CT scan at the age of 2 years.


Radiological features during follow-up. (A-C) CT images showing a NSIP + OP pattern and reticular and ground-glass opacities along the bronchovascular bundles with patchy air space consolidation before prednisone treatment. (C) The chest CT scan on admission (3 years of age).


Radiological features during follow-up. (D) CT images showing improvement after prednisone treatment for 3 months.


Radiological features during follow-up. (E) CT image showing progressive changes upon relapse of SLE after prednisone treatment for 1 year.


Radiological features during follow-up. (F) CT image showing no significant improvement after treated with prednisone plus CsA.


Radiological features during follow-up. (G-I) CT images showing improvement of NSIP after treatment with prednisone combined with CsA and pirfenidone for 7 months, 13 months and 26 months, respectively.


Chest CT findings before and after corticotherapy. (A): Patchy ground-glass opacity, mainly in the right lung.


Chest CT findings before and after corticotherapy. (B): Significant improvement after 3 weeks with prednisone.


(A): Brain MRI demonstrating right occipitotemporal lesion measuring 1.8 cm x 1.4 cm.


(B): Two months after rechallenge of osimertinib and reduction of the lesion, measuring 0.8 cm x 0.5 cm.


MRI images. . A. T1-weighted imaging showed a 7-cm multilocular ovarian cyst, which exhibited regions of high and low signal intensity.


MRI images. . B. A T2-weighted image is shown.


MRI images. . C. T1-weighted sagittal imaging showed that the ovarian cyst was located behind the uterus.


CT image of the route of the shunt. . The shunt tube ran through the left flank to the abdominal cavity.


Photos of the shunt tube obtained during the operation. . A. The head of the shunt tube was located in Douglas' pouch.


Photos of the shunt tube obtained during the operation. . B. The head of the shunt tube was moved to the vesicouterine pouch.


HE staining (x400) showing that the papillary area was composed of many cuboidal surface cells and rounded cells.


The solid area was mainly composed of rounded cells of similar size.


Focal hyperplasia could be found around the vascular wall in the sclerosing area.


A large number of red blood cells could be observed filling the lung interstitium and alveolar cavity in the hemorrhagic area (shown by the arrow in D); Histochemistry (x400) shows that the cuboidal surface cells of the tissue are positive for Pan-cytokeratin (Pan-CK) (shown by the arrow in E), while the rounded cells are negative for Pan-CK.


Positive for Epithelial Membrane Antigen (EMA).


Thyroid Transcription Factor-1 (TTF-1) The pathological manifestations are consistent with the diagnosis of PSP.


Case report timeline following CARE guidelines. . LAMA, long acting muscarinic agonist; LTRA, leukotrienes receptor antagonist; Q4W: every four weeks.


Chest computerized tomography (CT) before any therapy. (A, B) CT slices showed a mass lesion in the upper lobe of right lung and partial of right pleural thickening.


Chest computerized tomography (CT) before any therapy. (C, D) CT slices showed diffuse ground-glass opacities with interlobular septal thickening called as"crazy-paving"pattern.


BALF of right upper lung. (A) HE staining showed a large number of amorphous red-dyed materials, in which scattered in a small number of alveolar macrophages and inflammatory cells.


BALF of right upper lung. (B) PAS staining showed PAS positive in cytoplasm of some alveolar cells.


Pathology of transbronchial lung biopsy. (A, B) A few cancer cells infiltrated in the right lung apex section. Immunohistochemistry showed TTF-1.


Pathology of transbronchial lung biopsy. (C, D) Large amounts of amorphous red-dyed materials filled the alveolar space with PAS.


The lesion of wedge resection in upper right lung. (A) Adenocarcinoma differentiated grade II~III, mainly presenting as acinar and solid type, rarely papillary type.


The lesion of wedge resection in upper right lung. (B) Little amorphous eosinophilic scattered over the alveolar space around.


Chest CT after 2 cycles of postoperative chemotherapy. (A) No tumor recurrence in right upper lobe of lung.


Chest CT after 2 cycles of postoperative chemotherapy. (B) Diffuse consolidation and ground-glass opacity disappeared after therapy (wedge resection and 2 cycles of adjuvant chemotherapy).


Chest CT of ninth months after therapy. (A) A ground-glass nodule found in the superior segment of lower lobe.


Chest CT of ninth months after therapy. (B) A part-solid nodule found in the upper lobe of left lung.


Chest CT of ninth months after therapy. (C, D) Multiple subsolid nodules in lower lobe of both lungs.


Illustrate the serum glucose level in relation to dextrose injections during the interval of emergency department stay.


Computed tomography (CT) images of the chest. (A) High-resolution computed tomography (HRCT) shows bronchiectasis and bronchiolitis, ring-shaped or ductal opacities in upper, middle and lower lungs, some of which are accompanied by small nodules.


Computed tomography (CT) images of the chest. (B) Bronchiectasis involved in right middle lobe.


High-resolution computed tomography (HRCT) images after 20 days of azithromycin therapy. Nodular shadows were obviously attenuated.


High-resolution computed tomography (HRCT) images after 20 days of azithromycin therapy. But bronchiectasis did not change.


Computed tomography scan of the abdomen showing resolution of the gastric pneumatosis after 4 days.


Non-contrast computed tomography scan on presentation revealing gastric pneumotosis and extensive portal venous gas.


Computed tomography scan of the abdomen with contrast three days after the first scan showing resolution of the gastric pneumatosis and portal venous gas.


Computed tomography scan of the abdomen (lung window) showing extensive gastric pneumatosis and free intraperitoneal air superior to the liver (circle).


Fusiform dilatation of the trachea.


Tracheal dilatation and tracheomalacia with dynamic collapse during cough or forced expiration.


Tracheomegaly with an internal diameter of 46.32 mm.


A large, saddle pulmonary embolism (arrows) shown in computed tomography
angiogram of the chest, axial view.


Fluoroscopic image of the SENTINEL cerebral embolic protection device (Boston
Scientific) with proximal basket in the brachiocephalic trunk and distal
basket in the proximal left carotid artery.


Transesophageal echocardiogram shows the AngioVac System cannula (arrow)
retrieved back into the right atrium across the patent foramen ovale. The
left atrial portion of the clot (X) is visualized, as is the right atrial
portion of the clot (*).


Transesophageal echocardiogram and clinical specimen. (A) Negative flow
applied using the AngioVac system's inflow aspirates the clots in a
retrograde fashion into the right atrium across the patent foramen ovale. Microcavitation is seen on the right chamber and leftward interatrial
septum.


Transesophageal echocardiogram and clinical specimen. (B) Post clot extraction.


Transesophageal echocardiogram and clinical specimen. (C) Extracted specimen.


Family pedigree of the patient which demonstrates autosomal dominant inheritance.


A mixture of hypopigmented and hyperpigmented macules on the patient's trunk and extremities.


Chest x-ray. Right diaphragmatic paresis and poorly inflated right lower lobe.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (A) The section shows muscle tissue (big arrow) of the diaphragm and granuloma (star) surrounded by adipose tissue (white arrow) close to the serosa (small arrow) of the pleura, at magnification 200x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (B) Granuloma (star) at magnification 400x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (C) Non-caseating granuloma consisting of Langerhans giant cells (big arrow) and epithelioid cells (small arrow), magnification 800x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (D) Myositis with lymphocytic infiltrate (star) of the muscle tissue, already showing destruction of the muscle cells, magnification 800x.


Patient 1. Computed tomography scan showing left cerebellopontine angle lesion hemorrhage (a).


Patient 1. T1-weighted magnetic resonance imaging revealed a widened internal acoustic meatus and intratumoral hyperintense signal changes (white arrowheads) suggestive of hemorrhagic vestibular schwannomas compressing the brainstem. Axial.


Patient 1. . Coronal).


Patient 1. The corresponding areas are isointense (gray arrowhead) on T2W imaging indicating subacute (6-9 days) methemaglobin blood (d).


Patient 1. Contrast-enhanced T1-weighted scan demonstrated heterogeneous enhancement with widening of the internal acoustic meatus indicative of a multicystic vestibular schwannoma(e).


Patient 1. Susceptibility-weighted imaging revealed diffuse hypointense signal changes reflecting blood product deposition (f).


Patient 2. Computed tomography scan revealing acute intratumoral hemorrhage at right cerebellopontine angle causing brainstem compression The widened IAM is suggestive of vestibular schwannomas (a, white arrow).


Patient 2. And acute obstructive hydrocephalus.


Patient 2. One-month postoperative contrast-enhanced T1-weighted magnetic resonance imaging showing residual tumor extending into the IAM (c). Patient 3.


Patient 2. Computed tomography scan showing a left cerebellopontine angle hemorrhagic tumor (d).


Patient 2. Contrast-enhanced T1-weighted magnetic resonance imaging revealing a widened IAM and heterogenous enhancement (e).


Patient 2. SWI depicting intratumoral blood product deposition (f).


Bilateral, hypodense basal ganglia necrosis in unenhanced CT (arrows); Philips Ingenuity 5 mm.


Bilateral basal ganglia necrosis with T2w hyperintense alterations 3 T Philips Ingenia,. FLAIR.


Hemoside deposits. SWI.


These changes are diffusion-disturbed (C,D). B1000 image.


These changes are diffusion-disturbed (C,D). ADC map.


Flexible fiber-optic scopy view of the upper airway showing the epiglottis superiorly, an atretic larynx anteriorly, and esophagus (hollow tube) posteriorly.


Postmortem specimen of upper airway showing atretic larynx with no vocal cords and dilator in esophagus.


This is the patient's CT scan in an axial plane, in which you can see a right sided stomach, and you can see the liver's edges on both the right on left side.


Here is an intraoperative view, in which the liver, spleen, stomach and gallbladder are all seen on the right side of the abdomen.


This is a water-soluble contrast study done one day post-operatively using gastrograffin meal showing no contrast leak.


Pre-operative X-ray sequences: Pre-operative imaging revealed fracture of the left proximal humerus.


As well as left intertrochanteric femur.


Post-operative X-ray sequences: Proximal femoral nail for the intertrochanteric femur fracture (a-c).


Muscle biopsy showing inflammation and neutrophilic infiltration with muscle necrosis consistent with rhabdomyolysis. Courtesy of Department of Pathology, Saint Francis Medical Center.


Figure depicting the ingredients of energy drink 'NEON VOLT'.


Intraoperative defect after tumor resection.


Postoperative photographs.


Scout image of chest computed tomography showing elevation of both hemidiaphragms.


Admission chest x-ray shows bilateral infiltrates and chronic emphysematous changes.


Admission chest computed tomography, transverse view of upper lobes, shows dominant right upper lobe intracavitary lesion. The central component is 2.1 x 2.3 cm (previously 2.0 x 2.3 cm). The mural nodule within this cavitation is 2.1 x 1.2 cm (previously 1.5 x 1.0 cm) and thin walled. Imaging shows progression of right upper lobe bullous emphysema and cystic bronchiectatic changes.


Admission chest computed tomography, transverse view of lower lobes, shows new onset diffuse interstitial pulmonary ground-glass airspace opacities.


Admission chest computed tomography, coronal view, shows increased mediastinal lymphadenopathy, likely reactive.


Follow-up chest computed tomography after 5 weeks, transverse view of upper lobes, shows the mural nodule in the right upper lobe intracavitary lesion at 3.1 cm and partially calcified.


Follow-up chest computed tomography after 5 weeks, transverse view of lower lobes, shows near complete clearing of bibasilar opacities. Bilateral partially calcified nodules and amorphous/nodular opacities (more on the right than on the left) are visible, as well as bilateral bronchiectasis (also more on the right than on the left).


Follow-up chest computed tomography after 5 weeks, coronal view, shows stable borderline mediastinal lymphadenopathy.


Computed tomography of the chest before treatment of pembrolizumab. Left pleural effusion, left hilar lymphadenopathy, and left lower tumor were observed (A and B).


High-resolution computed tomography of the chest confirmed the presence of ground-glass opacities with subpleural sparing, interlobular septal thickening, a crazy-paving appearance, and traction bronchiectasis (A-C). Emphysema was also present in both upper lobes.


The bronchoalveolar lavage fluid gradually became bloody from the left tube to the right tube.


Pathological findings in biopsy specimens. Thickness of the alveolar walls with myxofibrous and lymphocytic infiltration changes. Agglutination of red blood cells with focal coagulate change was observed in the air spaces of the alveoli (H&E staining) (A).


Pathological findings in biopsy specimens. Thickness of the alveolar walls with myxofibrous and lymphocytic infiltration changes. Thickening of the alveolar walls with focal myxomatous early fibrous change was seen (Alcian Blue-Periodic Acid Schiff staining) (B). Scale bars, 100 mum.


High-resolution computed tomography of the chest indicated resolution of ground-glass opacities, 2 weeks after corticosteroid therapy (A-C).


Chest X-ray of patient on admission to local hospital post-intubation.


Clinical courses and medications. These graphs illustrate clinical course including fever, rash, lung lesions, peripheral blood eosinophil count (solid line) and serum alanine transaminase (ALT, dashed line) over time. Under the X-axis, the medications used for the treatment of heart failure and systemic steroids are shown.


Skin lesions on admission. There were variable-sized, occasionally fused, erythematous macules and plaques covering the skin of the entire body.


Imaging examination of the chest. (A) Simple radiographs of the chest on admission show diffuse heterogeneous increased opacities with a patchy distribution in both lungs.


Imaging examination of the chest. (B) Chest CT on admission shows multiple nodular consolidations with ground-glass density in both hemithoraxes and multiple mediastinal lymphadenopathy.


Imaging examination of the chest. (C) Simple radiographs of the chest after discontinuing the mexiletine and then treating the patient with oral prednisolone. The multiple infiltrative lesions disappeared from both lungs.


Microscopic observation of the biopsy specimen. (A) The tissue of the lung lesion shows eosinophilic infiltration with histiocytes and granular pneumocytes (H&E stain, x400).


Microscopic observation of the biopsy specimen. (B) The epidermis shows parakeratosis, exocytosis of lymphocytes with spongiosis, and vacuolization. The dermis shows extravasated red blood cells and moderate perivascular lymphocytes and eosinophils (H&E stain, x400).


Chest computed tomography scan image showing aortic irregularity (arrow) and retained left hemothorax.


Traumatic rupture of the pericardium with exposed left phrenic nerve (arrow).


Scleral melting 1 month after pterygium surgery.


Amniotic membrane graft in place secured with absorbable sutures.


Three weeks following amniotic membrane (AM) graft: complete AM integration and local inflammation resolved.


CT of the abdomen depicting finding consistent with emphysematous gastritis (axial view).


CT of the abdomen depicting finding consistent with emphysematous gastritis (coronal view).


Genetic results for case 2.


Histology of a prolactin-producing pituitary tumor. Tumor with diffuse growth pattern of cells with elongated nuclei and inconspicuous nucleoli and moderate amount of slightly acidophilic cytoplasm [(A):HE 400x.


Histology of a prolactin-producing pituitary tumor. Prolactin expression in neoplastic cells [(B):400x.


Thyroid ultrasonography (A) showed a normal size gland, with heterogeneous texture and pseudonodular areas, without nodular lesions, suggesting thyroiditis. The color flow Doppler signal showed significantly increased vascularity with diffuse homogeneous distribution (thyroid inferno).


There was a markedly hyperfunctioning thyroid in scintigraphy (B), with homogeneous activity distribution and no focal areas suggestive of hyper- or hypoactive nodular formations. The radioactive iodine uptake was 70.2% at the end of 24 h, markedly elevated compared to normal range (10-30.


Panel (C) shows the evolution of thyroid function. After pituitary surgery in 2009 the patient developed secondary hypothyroidism and initiated LT4. She was admitted with primary hyperthyroidism in April 2015 and initiated MMI. During antithyroid drug withdrawal before scintigraphy, FT4 and FT3 re-increased above the reference range. MMI was progressively reduced after 6 months of treatment, but after withdrawal in October 2015, central hypothyroidism recurred and she resumed LT4 since March 2016. Abbreviations: LT4, levothyroxine; MMI, methimazole; FT4, free thyroxine; FT3, free triiodothyronine.


Evolution of serum prolactin levels over time and its relation with medical, surgical, and radiation therapy. *Samples not diluted.


The left internal carotid artery angiography reveals severe stenosis in the right transverse-sigmoid sinus and superior sagittal sinus. (a) Anteroposterior view (white arrowhead).


The left internal carotid artery angiography reveals severe stenosis in the right transverse-sigmoid sinus and superior sagittal sinus. (b) Lateral view (black arrowhead).


The left internal carotid artery angiography reveals severe stenosis in the right transverse-sigmoid sinus and superior sagittal sinus. (c) Right anterior oblique view (white arrow).


The left internal carotid artery angiography reveals severe stenosis in the right transverse-sigmoid sinus and superior sagittal sinus. (d) Left anterior oblique view (asterisk).


Stature of the mother of the 9 years old affected by cleidocranial dysplasia.


Stature of the 9 years old male affected by cleidocra-nial dysplasia.


Depressed forehead with frontal bossing in mother.


Intraoral photograph of the 9 years old male affected by cleidocranial dysplasia.


Intraoral photograph of the mother of our patient (also affected by cleidocranial dysplasia).


Depressed forehead with frontal bossing in the child.


Hands of the mother of our patient (also affected by cleidocranial dysplasia), showing brachydactyly.


Orthopentamogram of the 9 years old male with cleido-cranial dysplasia showing deciduous retained teeth, numerous supernumerary teeth and dental age lagging behind chronological age.


Orthopentamogram of the mother (32 years) of the pediatric case of cleidocranial dysplasia (9 years), also affected with this condition showing deciduous retained teeth, poorly formed permanent teeth and impacted permanent teeth with supernumerary teeth and dental age lagging behind chronological age.


X-ray PA view chest of the 9-year-old male with cleidocranial dysplasia, showing laterally deficient clavicles.


Lateral cephalogram of 9 years old male with cleido-cranial dysplasia, showing parietal frontal and occipital bossing.


PA view head of 9 years old male with cleidocranial dysplasia showing open metopic fontanelle and suture with numerous Wormian bones.


X-rays showed. L1 upper end plate.


T12 lower end plate destruction with peri-vertebral shadow.


Plain X-ray demonstrating unremarkable features of the chest.


The magnetic resonance imaging of the spine revealed. Kyphotic deformity.


Pre-vertebral fluid collection at T12/L1 extending to the epidural space.


X-rays revealed intact spine post-surgery and decompression (a and b).


X-rays showing failed implants backing off from the. Distal part of vertebra (T12/L1).


Increased kyphotic deformity of the spine.


Contrast-enhanced computed tomography images showing the enlargement of the left kidney, renal pelvis, and ureter. And gas accumulation within the renal pelvis, ureter, and bladder The patient's right kidney is absent, and a thickened gastric wall can be observed (arrows).


Gas accumulation within the renal pelvis, ureter, and bladder The patient's right kidney is absent, and a thickened gastric wall can be observed (arrows).


Tumor cells are diffusely distributed, with beam-like structures and capsular invasion. CD56, syn and cgA expression is positive, supporting the diagnosis of pheochromocytoma.


Chest X-ray showing pneumopericardium.


Contrast enhanced chest computed tomography (CT) scan of patient after pericardial catheter and right sided chest tube insertion. Pneumopericardium, right sided pneumothorax as well as bilateral mild pleural effusion and collapse consolidation are evident. A: Axial view.


Contrast enhanced chest computed tomography (CT) scan of patient after pericardial catheter and right sided chest tube insertion. Pneumopericardium, right sided pneumothorax as well as bilateral mild pleural effusion and collapse consolidation are evident. B: Parasagittal view.


GMS stain illustrating hyphal elements.


Clinical picture showing dysplastic nails in all digits.


X-Ray of the knee showing absent of patella.


X-Ray of pelvis showing bilateral iliac horns.


(A and B) Histopathological findings of lung biopsy of right upper lobe, medium-sized vessels (arteries and veins) are rarely seen and are probably destroyed by the inflammation and replaced by scattered relatively small necrosis consisting of degenerating karyorrhectic neutrophils with basophilia and eosinophils with fibrinoid necrosis (probable foci of leukocytoclastic vasculitis). 8, there are small epithelioid granulomatous collections with occasional central small necrosis, and few multinucleated giant Langerhans-type cells are noted.


(A) 3-D analysis by SYNAPSE shows the lung lobes with a different color: yellow, right upper lobe; blue, right middle lobe; green, right lower lobe; red, left upper lobe; purple, left lower lobe.


(B) 3-D analysis by the SYNAPSE shows the emphysematous area. The larger the area, the more severe the emphysema.


The output in the Chartis system. (A) Right middle lobe: Higher leak airflow before blocking in the right middle bronchus. The airflow stops immediately and a progressive negative pressure is observed.


The output in the Chartis system. (B) Right upper lobe: Small leak airflow (less than 50mL/min) before blocking in the right upper bronchus. And the airflow gradually decreases and reaches zero in 3min and 1s.


(A, B) Chest X-ray and chest CT scan in October 2012. Patchy infiltrations predominantly around the pleura with air bronchograms in the left upper lobe are seen.


(C, D) Chest X-ray and chest CT scan in February 2013. Dramatic improvement is seen.


(E, F) Chest X-ray and chest CT scan in April 2013. Relapse of CEP showing infiltration in right upper lobe is shown.


(G) Chest X-ray in August 2015. Infiltrative shadow in left lower lung field is seen.


Clinical course of the patient. Oral prednisolone to control CEP was tapered off during mepolizumab therapy. Methotrexate was initiated for rheumatoid arthritis and mepolizumab was replaced by benralizumab. No exacerbations were noted after the discontinuation of benralizumab. The degree of respiratory symptom (*green) and arthritis (**blue) are indicated.


EKG showing early repolarization in anterior leads and diffuse T wave depression in multiple leads.


Coronary CTA showing a filling defect at the right coronary sinus (black arrow) at the level of the right coronary artery ostium suggesting thrombus occluding the proximal right coronary artery.


Normal left coronaries.


Left heart catheterization showing normal left coronary artery.


Sub-total occlusion of right coronary artery with filling defect at proximal segment (white arrow) consistent with acute thrombus.


The lesion was treated with balloon angioplasty and stenting with excellent results (D).


CTA of lungs showed moderate-sized filling defects in the left lower lobe consistent with pulmonary embolism (asterisk *).


Midesophageal four chamber view with color flow Doppler showing sub aortic ventricular septal defect with a left to right shunt.


Midesophageal right ventricular inflow outflow view in color compare mode showing the aortopulmonary window and the left to right flow across the defect into the main pulmonary artery.


Intraoperative surgical image (a) external anatomy (b) after opening the window. Figure shows posterior margin of the aortopulmonary window (W), openings of the Right pulmonary artery (**), left pulmonary artery (LPA), aorta (Ao). Origin of the right coronary artery is also seen (C).


Postoperative midesophageal four chamber view with color flow Doppler shows right to left shunt across the unidirectional flap valve used to close the ventricular septal defect.


Chest computed tomography (CT) images showing the ICI-related pneumonitis (CIP) (A) ground-glass opacity in both lungs.


(B) Inflammation absorbed after 2 weeks of glucocorticoid treatment.


(C) CIP recurrence after resuming nivolumab treatment. Ground-glass opacity (GGO) reoccurred, and more lobes of the left lung were involved.


(D) During the period of recurrent CIP, both lungs showed diffuse GGO, consolidation and the air bronchus-charging sign.


(E) Image after 7 days of corticosteroid pulse therapy. The extent of CIP was reduced.


(F) Image after 4 months of CIP treatment. The signs of pneumonitis subsided.


PSG trend graph of abnormal sleep structures obtained three months after onset. Recording Duration (min) 1342.1, from 11:01:45 to 09:23:52 the next day.


Results of 24-hour intraocular pressure monitoring in session 1 (blue line), session 2 (yellow line), and session 3 (green line). . Notes: Drop signs indicate the time of drop instillation. Shaded areas correspond to periods of sleep in the recumbent body position. . Abbreviations: IOP, intraocular pressure; mV eq, millivolt equivalent.


Electroencephalogram shows sharp-slow and delta discharges; bilateral frontal area.


Slit-lamp photographs of upper eyelid.


Lower eyelid. Showing adult lice (red arrows) and operculated oval nits (yellow arrows).


Social Responsiveness Scale-2 (SRS) sub-scores prior to the initiation of omalizumab (blue) and after the 6 month treatment period (red).


Aberrant Behavior Checklist (ABC) sub-scores prior to the initiation of omalizumab (blue) and after the 6 month treatment period (red).


Repetitive Behavior Scale-Revised (RBS-R) sub-scores prior to the initiation of omalizumab (blue) and after the 6 month treatment period (red).


Pittsburgh Sleep Quality Index (PSQI) sub-scores prior to the initiation of omalizumab (blue) and after the 6 month treatment period (red).


Total scores before initiation of omalizumab (blue) and after the treatment period (red) for the Epworth Sleepiness Scale (ESS), General Anxiety Disorder 7-item (GAD-7) scale, Clinical Global Impressions - Severity (CGI-S) scale, and the Rhinitis Control Assessment Test (RCAT). In contrast to other parameters, RCAT scores indicate better improvement with higher scores, while the rest of the tests indicate better improvement with lower scores. The Clinical Global Impressions - Improvement (CGI-I) was rated a 2 at the conclusion of the treatment period, indicating "much improved" symptoms.


Computed tomography scan of Patient 2 showing a left temporal arachnoid cysts.


Magnetic resonance imaging of Patient 3 depicting cerebellar tonsillar herniation.


Computed tomography of abdomen demonstrating bilateral adrenal hemorrhage with right adrenal gland measuring 5.3 cm superior to inferior x3.4 cm transversely x3.8 cm anterior to posterior, and the left adrenal gland measuring 6.1 cm superior to inferior x4.3 cm transversely x5.4 cm anterior to posterior.


Transesophageal echography showing a thrombus , originating from the right cavities.


Straddling the patent foramen ovale , originating from the right cavities. And extending into the left ventricle LA: left atrium, LV: left ventricle, RA: right atrium, LV: left ventricle.


Originating from the right cavities.


Extending into the left ventricle LA: left atrium, LV: left ventricle, RA: right atrium, LV: left ventricle.


(Left) Images of the thrombus. (Right) Surgical view of the embolus. IVC: Inferior vena cava, LA: right atrium, PFO: Patent foramen ovale.


Weight.


BMI. Trend before and after liraglutide treatment.


Photograph of the anterior segment of the left eye showing diffuse corneal edema with advanced keratoconus. Other anterior segment details are not visible.


Chest radiograph on admission demonstrating subcutaneous emphysema (red arrow) and pneumomediastinum (blue arrow).


(a and b) Sagittal reconstructed image through the thoracic spine and axial image at level of carina, lung settings, demonstrating epidural emphysema (green arrow).


(a, b and c) Contrast swallow of the cervical and thoracic oesophagus excluded oesophageal perforation.


Fluid attenuated inversion recovery (FLAIR) demonstrating pontine hyperintensity from lymphoma involvement.


Left hypodense M1 artery (red arrow).


Histopathology showing bone marrow constituents, and ,adipose tissue consistent with fat embolism.


Diffusion weighted imaging (DWI) showing left MCA territory infarction.


Initial presentation with massive swelling of right hand with involvement of hemithorax.


Axial CT chest demonstrating swelling of right hemithorax.


Pathology at 10x magnification showing a nodular, neoplastic proliferation composed of small ovoid to spindled cells demonstrating relatively bland, monomorphic nuclei and located within a variable fibrous to myxoid stroma.


Improvement in swelling after 1 cycle of chemotherapy.


Chest imaging showing signs of COVID-19. . A: Chest X-ray showing an abnormal shadow in the left lower zone on admission.


Chest imaging showing signs of COVID-19. . B, C: Chest computed tomography showing a patchy infiltrative shadow in the left lower lobe.


Chest imaging showing signs of COVID-19. . D: Chest X-ray showing improvement of the abnormal shadow on the day 8.


Clinical course and treatment of COVID-19 and rhabdomyolysis.


Normal sagittal view of the patient's cranial MRI at initial diagnosis of pseudotumor cerebri.


Sagittal cervical MRI of the same patient 10 years post lumboperitoneal shunting demonstrating a new "acquired" Chiari malformation and cervical syrinx.


Sagittal cervical MRI 6 months after ligation of the lumbar shunt, placement of a ventricular shunt, and suboccipital decompression with resolution of the syrinx and Chiari malformation.


Propositus: broad forehead with open metopic suture, pectus excavatum.


Father: mediofrontal depression, ocular hypertelorism, malar hypoplasia.


Father's hands: brachydactyly, brachytelephalangism, and broad thumbs.


(A) Chest x-ray of the propositus: cone-shaped chest, clavicular hypoplasia, enlarged shoulder joint space.


(B) Chest x-ray of father: cone-shaped chest, fragmented clavicles, scoliosis.


(C) Pelvic x-ray of father: narrow pelvis, with short femoral necks, and short pubic rami.


(A-C) Propositus skull CT, frontal, posterior, and lateral views: delayed ossification and wide-open sutures.


Catheterization study showing mild RPA origin stenosis.


Transthoracic echocardiography of the patient (parasternal long axis view).


Preoperative enhanced MRIs. Axial.


Sagittal) showing multiple tumors of the midbrain and obstructing hydrocephalus.


Plain CT 2-days after the procedures revealed a diffuse subarachnoid hemorrhage in the basal cistern.


Lateral view of the left internal carotid angiogram demonstrating the aneurysm of the internal carotid-posterior communicating artery.


Positron-emitting computed tomography of heart taken on August 11, 2008. (A) It shows higher fluorodeoxyglucose uptake of right ventricle comparing the left.


Positron-emitting computed tomography of heart taken on August 11, 2008. (B) The hyper-metabolic lesion due to right ventricular mass.


Transthoracic echocardiography taken on August 12, 2008. The mass arising from right ventricle was observed with the abnormal septal bouncing motion probably due to right ventricular pressure overload by mass effect. Heterogenous mass size of 2.52x2.54x3.25 cm observed.


Digital subtraction angiography of left subclavian artery of the patient. Digital subtraction angiography of the patient performed sixteen months after the initial presentation revealed significant stenosis of the left subclavian artery and stenosis at the origin of left vertebral artery. Other major branches of aorta including renal arteries were normal.


(A) Anterior-Posterior chest radiograph on hospital day 1 showing diffuse consolidative airspace disease. Radiograph was taken immediately following ECMO cannulation after transfer to our tertiary care facility.


(B) Anterior-Posterior chest radiograph on hospital day 12 (4 days prior to discharge) showing decreased opacification of both the middle and lower lung zones with marked improvement of degree of airspace disease.


Negative CD3 staining of patient's muscle biopsy, (20X).


Prenatal course of pleural effusion (PE) and its treatment. In total, three courses of betamethasone were administrated, allowing for complete prenatal regression of the PE.


Chest x-ray at clinical onset of symptoms, consistent with diffuse alveolar hemorrhage (DAH). There can be observed infiltrative opacification pattern mainly seen in the mid zones with apical sparing suggestive for impaired pulmonary microcirculation. There can be noticed areas of subdiaphragmatic air due to laparoscopy.


Chest CT scan without contrast medium confirming the diagnosis of DAH.


Chest x-ray after 48 h showing both lungs clear of significant parenchymal opacities and no signs of pleural effusions.


(A-C) Right lung lesions showed by CT scan (arrows). (A) Right upper lobe mass (arrow) measures approximately 4.0 cm shows in the first chest CT scan.


(A-C) Right lung lesions showed by CT scan (arrows). (B) The lung lesions shrunk after PD-1/PD-L1 inhibitors treatment.


(A-C) Right lung lesions showed by CT scan (arrows). (C) The lung lesions remained stable after discontinuation of pembrolizumab for eight month.


(D-F) Liver metastatic lesions shown by CT scan. (D) Liver metastatic lesions (arrow) measures approximately 1.7 cm showsin the first abdominal CT scan.


(D-F) Liver metastatic lesions shown by CT scan. (E) Liver metastatic lesions measures approximately 1.1 cm after PD-1/PD-L1 inhibitors treatment.


(D-F) Liver metastatic lesions shown by CT scan. (F) Liver metastatic lesions disappeared after discontinuation of pembrolizumab for eight month.


Electrocardiography obtained on admission for abnormal manifestations of serum myocardial enzyme spectrum. Rate of 168 beats per minute. Intervals in milliseconds: PR 70, QRS duration 68, QT 186, QTc 274. The electrocardiography indicated atrial fibrillation (fast ventricular rate type).


Variability of the acetaminophen serum concentration and levels of transaminases, during patient's hospitalization.


Immediate post op x-ray.


Serum calcium and intact PTH levels. . Notes: After the serum calcium was normalized, it did not change significantly over the three courses of denosumab. PTH continued to be elevated 2 weeks following denosumab administration. Subsequently, PTH was normalized owing to calcium supplementation. . Abbreviations: M, month; Ca, calcium; PTH, parathyroid hormone.


Bone turnover markers (TRACP-5b, total-P1NP) and eGFR levels. . Notes: TRACP-5b and total-P1NP levels decreased immediately following the first course of denosumab treatment. Renal function diminished mildly over the entire course of treatment. . Abbreviations: M, month; TRACP-5b, tartrate-resistant acid phosphatase type 5; total-P1NP, total N-terminal propeptide of type 1 procollagen; eGFR, estimated glomerular filtration rate.


1,25(OH)2D and 25(OH)D levels. . Notes: 1,25(OH)2D was suppressed following eldecalcitol supplementation. 25(OH)D level is higher in summer and autumn and lower in winter. . Abbreviations: M, month; 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin.


A single tumor mass in the supraclavicular area.


Holter electrocardiography during prodromal symptoms of syncope.


The main observation results in patient case 1: (A) MRI of the right basal ganglia and right occipital lobe.


(B) Magnetic resonance angiography (MRA) of neck and intracranial arteries.


(C) c-TCD test in the fourth cardiac cycle after Valsalva action.


(D) TEE examination.


The main observation results in patient case 2: (A) Brain MRI of left pontine by FLAIR sequences.


(B) Conducting Computed Tomography Angiography (CTA) of neck and intracranial arteries.


(C) c-TCD test in the 8th cardiac cycle after Valsalva action.


The main observation results in patient case 3: (A) Brain MRI of bilateral medulla.


(B) MRA of basal artery.


(C) c-TCD test in the 4th cardiac cycle after Valsalva action.


Skin changes in patient No. 1.


Skin changes in patient No. 2.


The time course of the changes in the patient's creatinine phosphokinesis (CPK) data. The patient's CPK level increased to 8832 IU/L on the fifth day of hospitalization and then showed a transient tendency to decrease. From the ninth day of hospitalization and following the start of rehabilitation, the patient's CPK level increased again to reach 105,945 IU/L on the 15th day of hospitalization. PE plasma exchange, CHDF continuous hemodiafiltration.


Trend of serum calcium and creatinine after washout of infected joint with Stimulan beads. Creatinine (Cr) mg/dL, Calcium (Ca2+) mg/dL.


Extensive diffuse bilateral interstitial and patchy areas of parenchymal density. Pleural thickening suspected bilaterally.


Fibrotic changes and traction bronchiectasis are seen at both lungs with upper lobes predominance in keeping with interstitial lung disease.


A section from the upper lobes showing elastic fibrosis in the sub pleural location extending into the parenchyma (blue arrow). Rare lymphoid aggregations are noted (green arrow). Minimal traction bronchiectasis (black arrow).


Sections from the upper lobes showing elastic fibrosis in the sub pleural location extending into the parenchyma (blue arrows). Margins between the normal lung and affected fibrotic areas are sharply defined (orange arrow).


Posttransplant chest X-ray.


A; Decline in AST/ALT levels following initiation of steroid therapy (orange arrow).


B; Correction of hyperthyroid state with decline in free T4 and recovery of TSH following initiation of steroid therapy (orange arrow).


C; Decline in CK following initiation of steroid therapy (orange arrow). C1D1, cycle 1 day 1; C2D15, cycle 2 day 15; HD, hospital day.


Chest CT showing the condensation in the left upper lobe (red arrows). The bilateral ground glass opacities are not present on this section. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article. ).


Histological section showing foci of pneumonia with many eosinophilic polynuclear cells (small arrow). Some alveolar ducts and alveoli are the site of endoluminal obstruction by fibrous granulation tissue consisting of inflammatory cells, fibroblasts, and connective tissue (big arrow). Magnification x400. Haematoxylin and eosin stain.


Aspergillus niger growing on Sabouraud dextrose agar. Aspergillus niger is the only pathogenic Aspergillus whose head is radiated, biserial and black at maturity.


CT abdomen. Huge right suprarenal mass measuring 16.5 x 6.5 x 8.7 cm.


CT abdomen. Right adrenal mass with break down areas and calcifications.


Mechanical ventilation and oxygenation before, during, and after prone positioning.


Histopathology examination revealed a large fibrotic area containing many granulomas (red arrow), consisting of epithelial cells surrounded by lymphocytes. Langhans giant cells (green arrow) were also seen at the periphery of the granuloma. There was no sign of malignancy. Histopathological findings were consistent with tuberculoma.


Preoperative photograph showing asymmetry of chin.


Preoperative cephalogram.


Intraoral distractor.


Postoperative cephalogram.


Changes in the patient's body weight and thyroid-stimulating hormone (TSH) level over time.


CT showed a 1.5cmx1.4cm mass in the middle lobe of the right lung, closely related to the bronchi (A, red arrow).


The tumor is mainly composed of lepidic-growing mucinous cells with papillary structures and abundant intra-alveolar mucus (B, 200x).


The skipping growth pattern of tumor cells can be noticed (C, 200x).


In certain glandular areas, the presence of basal cell layers could not be ruled out (D, 200x).


A mixture of ciliated cells and columnar cells could be observed in the glandular area (E, 200x).


No distinct boundary was found in the junctional zone between the glandular and the lepidic areas (F, 100x).


Hematoxylin-eosin (HE) and P40 stain of the glandular area with continuous basal layer, an area of 5x3 mm2 was demonstrated (A and B, 40x).