[ { "swissprot_id": "Q9W3K5", "sequence": "MGLLSEGSPLSWEETKALADHVREHGVNQFINLYHRLKDRQGDILKWGDEVEYIIVKFDDEQKVARVALRAQDLLAQLNEKELADPNGVKSLWRPEYGAYMIEGTPGKPFGGLMAHFNLVEANMRYRREEVTELLAKDECVMSITNFPRLGAPNFTYPLAQPRPEDPLSSARSLYFPDEAIFPGHPRFKTLTRNIRKRRGEKVSIKLKVFKDTKTKLPVEGAPPGEPDVVLLDAMGFGMGCCCLQLTFQACNITEARRLYDQLAPLCPIMLALTAASPIYRGYLTESDCRWNVISSSVDCRTEEERGLAPLDQQKFRIAKSRYDSIDSYLSPEGAKYNDVPLTYDEKVYQRLVEGGIDHLLAQHVAHLFIRDTVSLFSEKVHQNDNEDTDHFENIQSTNWQTMRFKPPPPNSSIGWRVEFRPCEAQISDFENAAIVCFVVLLTRVILSYQLNFLTPISKVDENMQTAQKRDACRKEKFWFRKSSKTTEQRAAKAQAQAQAQAKAQAQTNGKATLNGNGLANGNGNGSENSDQEEQQPLTNGSAKMNGHGSGTTNGTNGSSNGSSNGTDSDHTDTDDEENELFQLLSINEIFNGKPNVFPGLVPLIRSYLQSMEVDTDTHCTIEQYLRFIQKRAAGELITTATWMREQVLSHPDYKQDSVVSERINYDLLKRIQGIQEGKQVEPALLGQDYHSKTKTKDFIPPALQKQLAKNGCCEEK", "function": "Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.", "AFDB_id": "AF-Q9W3K5-F1-model_v4" }, { "swissprot_id": "Q9CWH0", "sequence": "MSYFGLETFNENQSEENLDEESVILTLVPFKEEEEPNTDYATQSNVSSSTLDHTPPARSLVRHAGIKHPTRTIPSTCPPPSLPPIRDVSRNTLREWCRYHNLSTDGKKVEVYLRLRRHSYSKQECYIPNTSREARMKQGPKKSKIVFRGIGPPSGCQRKKEESGVLEILTSPKESTFAAWARIAMRAAQSMSKNRCPLPSNVEAFLPQATGSRWCVVHGRQLPADKKGWVRLQFLAGQTWVPDTPQRMNFLFLLPACIIPEPGVEDNLLCPECVHSNKKILRNFKIRSRAKKNALPPNMPP", "function": "Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.", "AFDB_id": "AF-Q9CWH0-F1-model_v4" }, { "swissprot_id": "Q7XA07", "sequence": "MAAPAMLPGQAVKTPGSIWAKAIEHANEERKKPGADGRGDAFCYFVGSRAAGKSTLLNRFLYPTRAEVPKPSEGIEYTYARKPAAFDHEKKDLAHIWEVGGSQEFAEEIVNSDQLFLTAKQVTTAVVVIVVDLSDPAGVLPTLLYWVEQVKKKLGSTYEKFEKKGLQLPEQLRQRAKSKLYSANEDKDTVYHSGISLVIAATKYDAFKNQDPEVKKVMSRVLRYIAHAHGAFLCYLSGLHGASEGSGAEDAALLDNFTRLMNHLIFTGLEKKPVLKMQPQIDHTGPIMVPAGFDTFKSVGRPRSQGEGTVAGGLAEWRELFEKMFPGVREKEAKMSAKGAKFVIPEQYKEEEVDAVRQRKVTDLENFRKEQAAAVEAAKKKALMAKAQQAEAAAKKKAGAPAAGAKAPAKASPNGTPPRRPSNAGNQ", "function": "Functions as a motor for intraflagellar retrograde transport. Functions in flagellar biogenesis.", "AFDB_id": "AF-Q7XA07-F1-model_v4" }, { "swissprot_id": "Q70KD0", "sequence": "MEVEIRLGSVRYPFRLGTDCLGAIVEDLVAMSASRLLIVCDSNTGPLFGAELVERLSPRVPANLLIHRAGEPYKDLQAVGTLADSALQLGADRASVVVAVGGGVIGNIAGLMAALLFRGIRLVHIPTSLIAMSDSVLSLKQAVNACVGKNLMGTFYAPESVLADTAMLRSLPFRETVSGLCEVVKNSLAIRPSMVEMLRTSLRQDAVYDDETMYEIISESILAKASVTVDDMHECRAGLVLEYGHTVGHAIEYTAAGGLSHGQAIGLGMVVAAEVSHRLGHLDQEAVALHRELLTRAGAMVTIPEEVDLDEVMHRLRFDNKRGYLADPAESSAMVLLGGLGEPLWHDGRPLVSVPMALVGEVVNEIARPEIPNFELVAPVETVEEGRVPDTVGAADG", "function": "Catalyzes the intramolecular carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose (DOI).", "AFDB_id": "AF-Q70KD0-F1-model_v4" }, { "swissprot_id": "Q4PIK6", "sequence": "MSGMPNAELVREQQQPGDPMGSSAHPNAYVPEVGGLGSELPEAPRDKFFRKMREQPLVPIGSLLTCGALIAASNHLRSGNRDQFNKALRWRVGFQGLTVLAALVGSFYYGQQAAATIPAPASSSADAPLQQGAVTTLPGRAPTVWQQTRADERANKGRNEFEGRVGQALDRELNDDKRLEEALLGKEEEINLEQLKKTATKPRPVIGQDARRQV", "function": "Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.", "AFDB_id": "AF-Q4PIK6-F1-model_v4" }, { "swissprot_id": "Q8VZS8", "sequence": "MANSESSSSPVNEEENSQRISTLHHQTMPSDLTQDEFTQLSQSIAEFHTYQLGNGRCSSLLAQRIHAPPETVWSVVRRFDRPQIYKHFIKSCNVSEDFEMRVGCTRDVNVISGLPANTSRERLDLLDDDRRVTGFSITGGEHRLRNYKSVTTVHRFEKEEEEERIWTVVLESYVVDVPEGNSEEDTRLFADTVIRLNLQKLASITEAMNRNNNNNNSSQVR", "function": "Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA. Can be activated by both (-)-ABA and (+)-ABA.", "AFDB_id": "AF-Q8VZS8-F1-model_v4" }, { "swissprot_id": "O02326", "sequence": "MSVRIDEPQLFVSMSKEPTQETVNVGGHHDDSSSNCDERVDDQTEEQKSPPASPDLTANLNVFDLESRQKVVQRLLNSQLNLSNLRAPLNLPPIFQALQGPFSIQQQLLGLASGLTAISPGLDDYDEENTNQGEPEDLTLGGFRKETSVKSEEPSESGINASGPAWSYEEQFKQLYELSDDVKRKEWLDDWLNFMHRIGKPVTRIPIMAKQVLDLYELYRLVVQHGGLVEIINKKLWREITKGLNLPSSITSAAFTLRTQYQKYLYDYECEKEKLSNQSDLQQAIDGNRREAPGRRTAPSFPLPFQLPHAASAAATMLNNQLNGLGMRNDLLDDENTLSLQASGLFGTSYGAEQMAILEAHQRNLERAQRAVQQQVARQSLGLTACSNGNGGNIHNSGRESTSSNDSDIPAKRPKLENDVKTNGASSMRISTKHSDNSKTSMSVSMEINGITYQGVLFALDETVSES", "function": "Transcription factor. Regulates neuronal subtype identity. Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons. Probably acts by binding to specific promoter elements. Promotes differentiation of URA sensory neurons and prevents them from expressing male-specific CEM neuronal features. Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression.", "AFDB_id": "AF-O02326-F1-model_v4" }, { "swissprot_id": "Q8GJ44", "sequence": "MKRKVKKMAAMATSIIMAIMIILHSIPVLAGRIIYDNETGTHGGYDYELWKDYGNTIMELNDGGTFSCQWSNIGNALFRKGRKFNSDKTYQELGDIVVEYGCDYNPNGNSYLCVYGWTRNPLVEYYIVESWGSWRPPGATPKGTITVDGGTYEIYETTRVNQPSIDGTATFQQYWSVRTSKRTSGTISVTEHFKQWERMGMRMGKMYEVALTVEGYQSSGYANVYKNEIRIGANPTPAPSQSPIRRDAFSIIEAEEYNSTNSSTLQVIGTPNNGRGIGYIENGNTVTYSNIDFGSGATGFSATVATEVNTSIQIRSDSPTGTLLGTLYVSSTGSWNTYQTVSTNISKITGVHDIVLVFSGPVNVDNFIFSRSSPVPAPGDNTRDAYSIIQAEDYDSSYGPNLQIFSLPGGGSAIGYIENGYSTTYNNVNFANGLSSITARVATQISTSIQVRAGGATGTLLGTIYVPSTNSWDSYQNVTANLSNITGVHDITLVFSGPVNVDYFVFTPANVNSGPTSPVGGTRSAFSNIQAEDYDSSYGPNLQIFSLPGGGSAIGYIENGYSTTYKNIDFGDGATSVTARVATQNATTIQVRLGSPSGTLLGTIYVGSTGSFDTYRDVSATISNTAGVKDIVLVFSGPVNVDWFVFSKSGT", "function": "Endoxylanase that degrades arabinoxylan and glucuronoxylan to xylobiose and xylotriose (in vitro).", "AFDB_id": "AF-Q8GJ44-F1-model_v4" }, { "swissprot_id": "P60154", "sequence": "MKPLVIKFAWPLPLLLLLLLPPKLQGNYWDFGEYELNPEVRDFIREYESTGPTKPPTVKRIIEMITIGDQPFNDYDYCNTELRTKQIHYKGRCYPEHYIAGVPYGELVKACDGEEVQCKNGVKSCRRSMNLIEGVRCVLETGQQMTNCTYKTILMIGYPVVSCQWDEETKIFIPDHIYNMSLPK", "function": "Does not exhibit any ribonuclease activity.", "AFDB_id": "AF-P60154-F1-model_v4" }, { "swissprot_id": "Q21VW6", "sequence": "MNTPQNSPLGQATAYLDQYDASLLFPIARATKRAEIGVTGALPFLGADMWTAFELSWLNLRGKPQVALARFTVPCESPNIIESKSFKLYLNSFNNTRFADVDAVKARLRADLSEAVWRDAGKNVSPDAAAPPSIGVTLLLPELFDREPIYELDGLSLDRLDVECTHYTPAPDLLRVVPDEAPVSEVLVSNLLKSNCPVTGQPDWASVQISYSGAPIDQEGLLQYLVSFRNHNEFHEQCVERIFMDLWTRCKPVRLAVYARYTRRGGLDINPFRTSYAQALPANVRNARQ", "function": "Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).", "AFDB_id": "AF-Q21VW6-F1-model_v4" }, { "swissprot_id": "Q14679", "sequence": "MASAGTQHYSIGLRQKNSFKQSGPSGTVPATPPEKPSEGRVWPQAHQQVKPIWKLEKKQVETLSAGLGPGLLGVPPQPAYFFCPSTLCSSGTTAVIAGHSSSCYLHSLPDLFNSTLLYRRSSYRQKPYQQLESFCLRSSPSEKSPFSLPQKSLPVSLTANKATSSMVFSMAQPMASSSTEPYLCLAAAGENPSGKSLASAISGKIPSPLSSSYKPMLNNNSFMWPNSTPVPLLQTTQGLKPVSPPKIQPVSWHHSGGTGDCAPQPVDHKVPKSIGTVPADASAHIALSTASSHDTSTTSVASSWYNRNNLAMRAEPLSCALDDSSDSQDPTKEIRFTEAVRKLTARGFEKMPRQGCQLEQSSFLNPSFQWNVLNRSRRWKPPAVNQQFPQEDAGSVRRVLPGASDTLGLDNTVFCTKRISIHLLASHASGLNHNPACESVIDSSAFGEGKAPGPPFPQTLGIANVATRLSSIQLGQSEKERPEEARELDSSDRDISSATDLQPDQAETEDTEEELVDGLEDCCSRDENEEEEGDSECSSLSAVSPSESVAMISRSCMEILTKPLSNHEKVVRPALIYSLFPNVPPTIYFGTRDERVEKLPWEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPSFRSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDAKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNAEYQANADEMACQGHKWALKALWNYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNLAGFVLPNAEDIISSPSSCSSSTTSLPTSPGDKCRMAPEHVTAQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRILVEMEDEFSRRGQFERIFPSHISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVVSDSAPVWSLPTSLLTISKDDVILNAFSKSETSKLGKQSSCEVSLLLSEDGTTPKSKKTQAGLSPYPQKPSSSKDSEDTSKEPSLSTQTLPVIKCSGQTSRLSASSTFQSISDSLLAVSP", "function": "Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.", "AFDB_id": "AF-Q14679-F1-model_v4" }, { "swissprot_id": "Q14318", "sequence": "MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN", "function": "Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.", "AFDB_id": "AF-Q14318-F1-model_v4" }, { "swissprot_id": "A0A075B6N2", "sequence": "MLLLLLLLGPGSGLGAVVSQHPSRVICKSGTSVKIECRSLDFQATTMFWYRQFPKQSLMLMATSNEGSKATYEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAR", "function": "V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.", "AFDB_id": "AF-A0A075B6N2-F1-model_v4" }, { "swissprot_id": "P42107", "sequence": "MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSMLGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVPLYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLFSIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGMLTYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLYSVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVCTWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLSWQPIAKKTKV", "function": "Involved in transport.", "AFDB_id": "AF-P42107-F1-model_v4" }, { "swissprot_id": "O13351", "sequence": "MSESPSANISDADKSAITPTTGDTSQQDVKPSTEHINLKVVGQDNNEVFFKIKKTTEFSKLMKIYCARQGKSMNSLRFLVDGERIRPDQTPAELDMEDGDQIEAVLEQLGGCTHLCL", "function": "Required for chromosome segregation where it may be involved in microtubule assembly. Loss of smt3 leads to an increase in telomere length.", "AFDB_id": "AF-O13351-F1-model_v4" }, { "swissprot_id": "P33338", "sequence": "MSRIDSDLQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEAIRDRDWIRSLGRVHSGGSSYSKLIREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVSVSDPDEGYETILDLMSLQDSLDEFSQIIFASIQSERRNTECKISALIPLIAESYGIYKFITSMLRAMHRQLNDAEGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKLPVDAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPTGATTGMMIPTATGAANAIFPQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQELFQQQLQKAQQDMMNMQLQQQNQHQNDLIALTNQYEKDQALLQQYDQRVQQLESEITTMDSTASKQLANKDEQLTALQDQLDVWERKYESLAKLYSQLRQEHLNLLPRFKKLQLKVNSAQESIQKKEQLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMTQDKMNPILDAILESGINTIQESVYNLDSPLSWSGPLTPPTFLLSLLESTSENATEFATSFNNLIVDGLAHGDQTEVIHCVSDFSTSMATLVTNSKAYAVTTLPQEQSDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEKLQELSLAIEPLLNIQSVKSNKETNPHSELVATADKIVKSSEHLRVDVPKPLLSLALMIIDAVVALVKAAIQCQNEIATTTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSLGNHVMGMIEDDHSTSQQQQPLDFTSEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHAYYNQDDD", "function": "Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H(+)-ATPase on the cell surface.", "AFDB_id": "AF-P33338-F1-model_v4" }, { "swissprot_id": "Q505H7", "sequence": "MEADYYSPEHSDADDGGATPVQDERDSASDDEGNEREQRSEPGSPERQSEDEHSDIEDNKHRSDSGSDNEEGAEHNDSEDEHRPHNSSDLENHDASDSENEESRNHIASDSEDDVRRQKGSDSEGSPVKDAASDSDEEPIRHSASDSEDDGPRKEQANDSEDERHKKNTASDSEDEAPAKHQGSDSEDEAPAKHVASDSEDEAPAKRAASDSEDEAPAKRAASDSEDEAPAKRAASDSEDEAPAKRAASDSEDEAPAKRAASDSEDEAPPKRAASDSEDEAPPKRAASDSEDEAPPKRAASDSEDEAPAKRKVSSSEDEAPSKQAFSASKKSSKKSSGDSEDKARGKRAIIDSDDEDEDVPVKRAASDSEEETHPKGKASDSEDEAPSKQQPSDSEEETPAKAAANNSEDEFPRMKRKIVSSDDSDDEIDRKPLQKKKKKSPRRSSESDSSDKVDSKKRKASESDEEEEKASKKKSAILSDSEDEDAANKSGNKKSRILSDGDDSDSDAGSDRPKQKKKLASSDSEEEDELKSKTEAKNADKLFGSESDSGNEEENLIADIFGESGDEEEEEFTGFNQEDLEGEKTVTSANKQHAAAADSDSDDDDVKPGKMGDFKSDFEIMLERKKSMSGKRRRNRDGGTFISDADDVVNAMIMKMNEAAEEDRNLNSSKKPALKKLTLLPTVVMHLKKQDLKETFIDSGVMSAIKEWLTPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRPNKDIAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMSSSGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPLPSNKDYVVRPKWNVEMESARYQGSSKKGVSRLDKQMRKFVDIKKKNRFGHAVKISIEGNKMPL", "function": "Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts.", "AFDB_id": "AF-Q505H7-F1-model_v4" }, { "swissprot_id": "Q99958", "sequence": "MQARYSVSDPNALGVVPYLSEQNYYRAAGSYGGMASPMGVYSGHPEQYSAGMGRSYAPYHHHQPAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVSKEKEERAHLKEPPPAASKGAPATPHLADAPKEAEKKVVIKSEAASPALPVITKVETLSPESALQGSPRSAASTPAGSPDGSLPEHHAAAPNGLPGFSVENIMTLRTSPPGGELSPGAGRAGLVVPPLALPYAAAPPAAYGQPCAQGLEAGAAGGYQCSMRAMSLYTGAERPAHMCVPPALDEALSDHPSGPTSPLSALNLAAGQEGALAATGHHHQHHGHHHPQAPPPPPAPQPQPTPQPGAAAAQAASWYLNHSGDLNHLPGHTFAAQQQTFPNVREMFNSHRLGIENSTLGESQVSGNASCQLPYRSTPPLYRHAAPYSYDCTKY", "function": "Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.", "AFDB_id": "AF-Q99958-F1-model_v4" }, { "swissprot_id": "Q03714", "sequence": "MSEYLAQTPCKFTIWSSEIDLIRTNLLVNAHPLSTVGRLLQYIHYQIYKQLRAIYQPEEQCTNSEIPHTPLNSINTYFLSYEGRELSATCLLKDITSSSHPDSNHFIRLQLEKRTSPSGSAFDLEYDMEGEFNSMNIQFEINTLSSQRIFNSMEPNLPIGTTLARLEKLALERIKDFEKSAGNLCGIKEDHSVSDLQGFIIKGKQTPMFLNYGSDSDYYKDLNLVDLIGIDFAPAHNSFFTFLFKMNHEQNSHIANDEERFVLEFISDATLSITQMNVKPDTTVKQVKDFICSVYTHSLNLRRNDIKLIYKGQLLHENNFAGNSSKISEYIKEPHEVKVHVQINQEYTESGPGFWNEVFNNPNIFQFMPPDTRSQSPVSFAPTQGRSPAAIRGEERGIPYVTESGNDIVPTDELYRKCIINGDEVVFIPVSELNPQSSYLSVIKGDYGEIKIPISSNDYRINGDNILLSPSAIEQLESALNFKIERPRDSTLLHPSGEHVRAADNTSSANDNNTVENDESAWNRRVVRPLRNSFPLLLVLIRTFYLIGYNSLVPFFIILEFGSFLPWKYIILLSLLFIFRTVWNTQEVWNLWRDYLHLNEIDEVKFSQIKEFINSNSLTLNFYKKCKDTQSAIDLLMIPNLHEQRLSVYSKYDIEYDTNTPDVGQLNLLFIKVLSGEIPKDALDELFKEFFELYETTRNMNTLYPQDSLNELLLMIWKESQKKDINTLPKYRRWFQTLCSQIAEHNVLDVVLRYIIPDPVNDRVITAVIKNFVLFWVTLLPYVKEKLDDIVAQRARDREQPAPSAQQQENEDEALIIPDEEEPTATGAQPHLYIPDED", "function": "Scaffold protein of the endoplasmic reticulum-associated degradation (ERAD) (also known as endoplasmic reticulum quality control, ERQC) pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Has multiple functions in ERAD including recruitment of DER1 to the HRD1 ubiquitin ligase, and regulation of HRD1 activity. Involved in oligomerization of HRD1 and in HRD1 autoubiquitination and degradation.", "AFDB_id": "AF-Q03714-F1-model_v4" }, { "swissprot_id": "Q86KL1", "sequence": "MSMDHQDLKRRDPPADSESQRPSKKISLSSSEASVPIGGPPIDQNLILFQNRAMKVRVEEQKIEINDREQKIKQLNTKIHQYKENISCLCRVWDQLNSGLDLLINRVDFENAMDNLLPKDNITESFEFLSSYITEPVTLDEKYTLDQSLQKKVQKTQSTFSKISKALEKEHTLSKFVFRLLKSKDGIKSNDIEKLLKEDNDKLSKQNQYIQNIYDKVQIQFKQLTDQTTHLADQAAIYQQNNKELKLELEKSQDELTIERKRVIKLQDETLRTPQVKIPSPSLGSNIPGGANNNNNNNNNSNNNNNINNNGNNMGGSGSSSLASSTNGINKQQSNDINGKELTHEELIAELQRQSDSRLLEARKLREEKAILLKELQQIQIDIRVIPEERIQNSMPYQVLRQRYQLVSDELDIHRNQCTKLQNDLAQATIGRRLEREALEAFEAHRRQNIERRVSQLEVESIELKGEKEKLVCLIEQRNPNVPSLQYIQESRLLLDKKDDEIKQLRKEIEQLKLDIEKYKAPKEEIERYKLLVQRDVESKNIEINKLLEKINTITKQNNDLKSNEQQLLQKESELTLSLNILKSNKNNININNLDKDNIEDNSKIKQQQEQQQQQHQKIDNNNKKEEEIKKEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEEQKKDKEMIDIEKSTENIINNNNNNNTNEQKLNEINKNIENGNNENNNNNENTINNENTINNNNNENKDKIIFNLELNESKLKLELSTVKKQLEDITKSKEEYDNEIKEINEKFKAQIKELDITISQNKIQQESQKQELEALVMEIDSMGKAYEQMLEQNTRLTKQLSDKEDTHAHLMAENIKSQQTIRNSKEIQLAIEEKLNRNEEKLKSQGELMQKIEEKSNILQKQLSKVTEDLHSCSFDLEKHKRFVRENNAHSLELKTQLDHLSNLNAELKKKADDSIFALEREIDKAKRLDEEKQLLKKKLEKATSANNNNNNNNNNNNNNNNNNSSSSEEELKLINQRLRCTICNDRQKNYVIAKCFHVFCKECIYSNIDTRKRRCPSCNRAFAETDVHQIYY", "function": "E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B.", "AFDB_id": "AF-Q86KL1-F1-model_v4" }, { "swissprot_id": "Q97UZ0", "sequence": "MMKKGTIILVAPTAIFSAILLYLVIWNAVMSFMNWSLLNSKPTFVGLETYSIVIRTFQFTNSLLHSIELSVILVVIGNILGIFIAALLYFLNSNKARSTFLSIVIYPLSISMAVNGLIWLWLFNIHIGVDWLLVRIGLPQFPWLSSTSTMFPSLVLVSVWAYTGIAALFYLAGFMNIDKTIVEAARLDGTSAFKILYKILIPNSLNSFIIATALLFLFSFRIFDLPYVLSGGTTNIFLQTSELYMYYLFTVEYFSQATAVATMITLIATIIIIPYALTVIRRWIRR", "function": "Part of the ABC transporter complex GlcSTUV involved in glucose uptake. Responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-Q97UZ0-F1-model_v4" }, { "swissprot_id": "Q96PG8", "sequence": "MKFGMGSAQACPCQVPRAASTTWVPCQICGPRERHGPRTPGGQLPGARRGPGPRRPAPLPARPPGALGSVLRPLRARPGCRPRRPHPAARCLPLRPHRPTRRHRRPGGFPLAWGSPQPAPRPAPGRSSALALAGGAAPGVARAQRPGGSGGRSHPGGPGSPRGGGTVGPGDRGPAAADGGRPQRTVRAAETRGAAAAPPLTLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDSGGRPLPPPDTLASAGDFLCTM", "function": "Does not affect cell growth.", "AFDB_id": "AF-Q96PG8-F1-model_v4" }, { "swissprot_id": "B8I6E7", "sequence": "MEKARIYELAKELNTTSKRLMEKLAEIDISVKNHMSLLEPHELDALYKHIGVIRHDDKKNEVEEKKTVAESTNTTEKKKEVKKEVKKENKNAPRIIRTTEIIIDSSTEDSSGANNFPKNETKNVQKKNYKNNFVKVESSTSGLRPGFVRDVKPDLRNKQNAASSKNEVKKALPKETSAPKEEVLNSKIINEDIHKEEKTVADNKGNGSKVLKGSSNTESAQLNNKVAAVEKEEQKSINKPESAQISTQSENKPQQSNGAKQPEEAVVSVNKDSIGKSEQVTAQNDVPSVNKVHPQEKPVHRTDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPQGQYNNQRSDRPHGQYNNQRSDRPQGQYGNKRPDRPQGQHRQQNLDIPKPDASVAQEAFDSQRNEARREFQGRDFDKNVKREEKQKKEAPKSNTATKQRFRPQKIVIEKKGVSEILSEDYIFNEFYNDDGKKKKHRNKRNDKVQVKYIPPKAVLTSITIPESLTVKDLAESLKKTSTEIIKKLMAYGVMATLNNEVDFETATIIAEEYGVKTEKAIQVSEEDILFDDDEVQDESKLQPRPPVVVVMGHVDHGKTSLLDAIRSEHVIDSEAGGITQHIGAYTVKANDRAITFLDTPGHEAFTAMRARGAQVTDIAILVVAADDGVMPQTIEAINHAKAANVTIIVAINKIDKPSANPDKVKQELTEYGIVAEEWGGDAIMVPVSAKKRENIDQLLEMVLLAADMLELKADPERQAKGTVIEAKLDKERGPVATVLVQRGTLKTGDSLIAGSTFGRIKAMTSDKGHAIKAAGPSIPVEILGMDEVPEAGEVFYAVTEDKVAKHLVEKRKFKQKEQQFKATSKVTLEDLFTQIKEGKVKDLNIIIKADVQGSVEAVKQSLEKLSNDEVRVKTIHGAVGAITESDVTLAQVSNAIIIGFNVRPGANVTEAAKNAEVDMRLYSVIYKAIEDVQAAMNGMLEPTYKEVILGHIEIRQIFKVSGVGTIGGAYVTDGKVQRNSEVRVVREGIVIHEGKLASLKRFKDDVKEVAQGFECGVSIERFNDIKEGDVIEAFVMEEVKR", "function": "One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.", "AFDB_id": "AF-B8I6E7-F1-model_v4" }, { "swissprot_id": "Q95104", "sequence": "MVWQGLVLAACLLALPSVTADCLAQCSLCAVKTQDGPQPINPLVCSLECQAALQPAQEWERCQGLLSFLTPFTVGLNGKEDLKSKTVLEESSSEPAKHIRPYLKELEKNRFLLSTPAEKNALSSSLVEKLRGLSGRLGEDAESELMGDAQLNDGALEAEARDSNEEEPKEQVKRYGGFLRKYPKRSSEVTGKEAGEGEGGEVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPSAYYEELFDV", "function": "Leumorphin has a typical opiod activity and may have anti-apoptotic effect.", "AFDB_id": "AF-Q95104-F1-model_v4" }, { "swissprot_id": "Q0WUF6", "sequence": "MGGNKQRWFSFHQRSSSATTTTLPQHKHDETPPEFLCPITGFLMSDPVVVSSGQTFERLSVQVCRNLGYIPDLLDGTRPDLSTVIPNLAMKSTIFSWCDRQKVDHPRPPDAAYVEGVVRARMDKDPNPSPGQSPGPGDKDPEPEILPPVEENSPSDYDAVMEAIRARSKNSMSPTTSLESVTIGQSSYHPVRAVSMFSSSTTSSSSGVFAGADSPFRNAMSFSSTDHSSSPMSPEEEEIFNKLRGTDIFDHEQGLILLRKMTRSSEDLRVSLCTDRILSFLRSLLVSRYNLVQTNAAASVVNLSLEKQNKVKIVRSGFVPLLIDVLKSGTTEAQEHVAGALFSLALEDENKMVIGVLGAVEPLLHALRSSESERARQDAALALYHLSLIPSNRTRLVRAGAVPTLLSMVRSGDSTSRILLVLCNLAACPDGKGAMLDGNAVAILVGKLREVGGGDSEAARENCVAVLLTLCQGNLRFRGLASEAGAEEVLMEVEENGNERVKEKASKILLAMRGGGGGESEFGENAEAREWNRMLEATGLSRTQFQGGQNGGFAYSSQF", "function": "Functions as an E3 ubiquitin ligase.", "AFDB_id": "AF-Q0WUF6-F1-model_v4" }, { "swissprot_id": "Q9P7B8", "sequence": "MAEGDFKNDSTGCIGDSVEFTTFKKRTGKSLGNRRKKRGLSGWEPYFQEPELTAEEKLENETLYSRNIPLTVRMERFIQRYRSRRKWSDPTRIRLFTMYLDLGGVSTGQKQFTGGTDINNDAKAREVSAQTTTDYIEYDILDEYDIDFKWVAGVFLSSHILYNAGLTKEEDLQIACQIVRNFLLSVLHNNVAPEFEDNIRDACLLAEQAETELISNKRLSTKLPGRLQRALASIHVDNYKGLWDKSQSDRTSDSSVNFIESNNTKFMPNDELFEPDGISRFSTQQARDYIQRTLGPRYLTGKVVEQEYLTVKLVSKTLLNFSNQSLCKAVFIVWDPPGSKYSQDTNKERLEVILESDLLNNTVDGTHLEGSFTFLDNGLTILDTVLAVLPTFYEEVKDE", "function": "Component of the argonaute siRNA chaperone (ARC) complex which is required for histone H3K9 methylation, heterochromatin assembly and siRNA generation. The ARC complex contains mostly double-stranded siRNA. Inhibits the release of the siRNA passenger strand from ago1 together with arb2. Inhibits the slicer activity of ago1. Required for swi6 localization to the centromeric repeats.", "AFDB_id": "AF-Q9P7B8-F1-model_v4" }, { "swissprot_id": "Q5KYR2", "sequence": "MSRLIIPSHSPNEEGNVVRVTPESVGWEYVGFEVYVLAKGQTLRKETKDQEACLVLLKGKANISTKLERWEQIGLRMDVFEKVPPYSVYVPANDVYEVEAMTDVEVAVCLAPGKGTYPARLIPPSEVGVEIRGAGNIERRVHNILPESQPADSLLVVEVFTPEGNWSSYPPHKHDQDNLPHESYLEETYYHKINPGHGFMVQRVYTDDRSIDETMVVKNGDVVLVPKGYHPVSAPPGYEGYYLNVMAGPVRTWKFHNDPDHDWVMESKLAAKQKEK", "function": "Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).", "AFDB_id": "AF-Q5KYR2-F1-model_v4" }, { "swissprot_id": "Q94CV1", "sequence": "MSGRSSRRGSFSLRQPPVVDIGCNCRRPKLFSIFSSSSSSSFRRGGSKPKSPNASSTSTTTAFTATTGGAGTATSTDSSWGPASFTTNSLFEEPAAAQQEQEQLETRRRRRQQRRRRRRAGATSFARGGDVGGHDDEQQQLQEQAPYRRVAKESVAVAVESAEPYEDFRESMVQMVVEKEIYAWDDLNDLLHQFLSLNSPRHHPLILHAFADLWTRNGLFSPPSPCQF", "function": "Probable transcriptional repressor that regulates multiple aspects of plant growth and development, partly through brassinosteroid (BR) signaling pathway. Acts downstream of the kinase GSK2, a negative regulator of BR signaling.", "AFDB_id": "AF-Q94CV1-F1-model_v4" }, { "swissprot_id": "Q9FT74", "sequence": "MKDQDLELEKVRLISLATKLGFDEDSAKKCLDRFVDLYGDDGRDFITVELCGDDFLAALADFEEGTEEWDDIQAIESEAQGNLAEMFDKSTNPSDNGFDTDDDDDDSRVEVHVIEDSPEPKKKPEIVELDSSSDLEDVETRFKVPRRSQTCSRSMDYSMEDSVSTISGRKPSVQISNKDHETPSYEELQALDDLEFANLVIFGNKVFRPLQHQACRASMERKDCFVLMPTGGGKSLCYQLPATLKAGVTIVISPLLSLIQDQIVALNLKFGIPATFLNSQQTSSQAAAVLQELRRDNPSCKLLYVTPEKIAGSSSFLETLRCLDRKGLLAGFVVDEAHCVSQWGHDFRPDYRELGCLKQNFPRVPVMALTATATESVCQDVLKSLRIPRAPVLKMSFDRINLKYEVIVKTKEPLKQLQELLRDRFKDQSGIVYCLSKSECVDVAKFLNEKCKVKTVYYHAGVPAKQRVDVQRKWQTGEVRIVCATIAFGMGIDKADVRFVIHNTLSKAVESYYQESGRAGRDGLQAQCICLYQKKDFSRVVCMLRNGQGRNMDRFKSAMAQAKKMQQYCELKTECRRQMLLEYFGESFDRMICKSSLNPCDNCERS", "function": "3'-5' DNA helicase that may play a role in the repair of DNA.", "AFDB_id": "AF-Q9FT74-F1-model_v4" }, { "swissprot_id": "Q5KV89", "sequence": "MGVVHDVWLVTKELLEATALPWPSEEREERLAAVDRLLLEREELLRKLRPPYSEEEQELGREIIVWNQEIEARLLRVCEEIRRDLRMTGAKRQANARYVHPYEQPLSFDGMFYDKRR", "function": "May act as an export chaperone for the filament capping protein FliD.", "AFDB_id": "AF-Q5KV89-F1-model_v4" }, { "swissprot_id": "A0A0H2URJ6", "sequence": "MRNTKRAVVFAGDYAYIRQIETAMKSLCRHNSHLKIYLLNQDIPQEWFSQIRIYLQEMGGDLIDCKLIGSQFQMNWSNKLPHINHMTFARYFIPDFVTEDKVLYLDSDLIVTGDLTDLFELDLGENYLAAARSCFGAGVGFNAGVLLINNKKWGSETIRQKLIDLTEKEHENVEEGDQSILNMLFKDQYSSLEDQYNFQIGYDYGAATFKHQFIFDIPLEPLPLILHYISQDKPWNQFSVGRLREVWWEYSLMDWSVILNEWFSKSVKYPSKSQIFKLQCVNLTNSWCVEKIDYLAEQLPEVHFHIVAYTNMANELLALTRFPNVTVYPNSLPMLLEQIVIASDLYLDLNHDRKLEDAYEFVLKYKKPMIAFDNTCSENLSEISYEGIYPSSIPKKMVAAIRSYMR", "function": "Also catalyzes the fourth step in glycosylation of PsrP in this bacteria. Can transfer the sugar from UDP-galactose to the terminal sugar moiety of PsrP-GlcNAc-Glc-Glc and of PsrP-GlcNAc-Glc-Gal.", "AFDB_id": "AF-A0A0H2URJ6-F1-model_v4" }, { "swissprot_id": "O14096", "sequence": "MAISSLSSPSGARVSSVTVKNKVLKTPCFFLPTSRGTVPHLTPDNVEEFDIPALYVGLEDCLDRLEASPILTNEGTIKKWIAAPSVQPTLLAPRRTSPLPSVSAGQSHINIVTASGAKKLTNDLYIKAVLKLCPELVIPLNDTPTSPPGVKRKPKIVERSVNWTTELLLALKATDAFNTTKVFFPVPDLDTQYLTPIFQFFQENQLANNIAGLAFSNNVNPLPADLVGLPRLSIQKFESPLEILKCIQRGIDIIVPDMITQATDAGVALTFSFPPPSKDVLNSKIELGLDMWDERFATDMEPLQSGCVCKTCRRYKRAYVRHLLQARELVAWILLQLHNVYAFTAFFQGIRASIQEGNFDEDVRKFEEIYMTSFPASHGFGPRKRGYQMDLTNVQPVENKPAWISMKSPLEKEIANEYEALKVTERKEDTQDYNEPELHNSNDPTVDLYADTYATQAATESDSELEDALFSQLDEFDDTAYREQRLEMLKKEFARVEAAKEKGHMQFLTVENEREVMDFTLSSKKVVIHFYHPDFIRCKIIDSHLEKIAKVHWETKFIRIEAANAPFLVVKLGLKVLPAVLCYVNSQLVDKIIGFADLGNKDDFETSLLEFRLLKSSAIDRLKEESSSNKSIYHDELQNNQSDDSDFFE", "function": "Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).", "AFDB_id": "AF-O14096-F1-model_v4" }, { "swissprot_id": "O00155", "sequence": "MAPTEPWSPSPGSAPWDYSGLDGLEELELCPAGDLPYGYVYIPALYLAAFAVGLLGNAFVVWLLAGRRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAAALGGRWPFGDGLCKLSSFALAGTRCAGALLLAGMSVDRYLAVVKLLEARPLRTPRCALASCCGVWAVALLAGLPSLVYRGLQPLPGGQDSQCGEEPSHAFQGLSLLLLLLTFVLPLVVTLFCYCRISRRLRRPPHVGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGALPLPCPLLLALRWGLTIATCLAFVNSCANPLIYLLLDRSFRARALDGACGRTGRLARRISSASSLSRDDSSVFRCRAQAANTASASW", "function": "Orphan receptor.", "AFDB_id": "AF-O00155-F1-model_v4" }, { "swissprot_id": "P32240", "sequence": "MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI", "function": "Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.", "AFDB_id": "AF-P32240-F1-model_v4" }, { "swissprot_id": "A0R5K4", "sequence": "MTSPSIESGARERTRRAILDAAMLVLADHPTAALGDIAAAAGVGRSTVHRYYPERTDLLRALARHVHDLSNAAIERADPTSGPVDAALRRVVESQLDLGPIVLFVYYEPSILADPELAAYFDIGDEAIVEVLNRASTERPEYPPGWARRVFWALMQAGYEAAKDGMPRHQIVDAIMTSLTSGIITLPRT", "function": "Represses the transcription of the lfrRA operon by binding directly to the promoter region of lfrR-lfrA. Binds specifically to a 143-bp region upstream of the lfrR gene.", "AFDB_id": "AF-A0R5K4-F1-model_v4" }, { "swissprot_id": "Q06147", "sequence": "MTLKPSKRRKGRSRHSRKKQITSAILTEEGIMIKAKPSSPYTYANRMADKRSRSSIDNISRTSFQSNISRTSFQSNSDNNSIFETASLISCVTCLSDTDTIDRSETSTTDTSKDDLSANPKLHYPSVNGQLPANTVIPYGRILDARYIEKEPLHYYDANSSPSSPLSSSMSNISEKCDLDELESSQKKERKGNSLSRGSNSSSSLLTSRSPFTKLVEVIFARPRRHDVVPKRVSLYIDYKPHSSSHLKEEDDLVEEILKRSYKNTRRNKSIFVIINPFGGKGKAKKLFMTKAKPLLLASRCSIEVVYTKYPGHAIEIAREMDIDKYDTIACASGDGIPHEVINGLYQRPDHVKAFNNIAITEIPCGSGNAMSVSCHWTNNPSYSTLCLIKSIETRIDLMCCSQPSYAREHPKLSFLSQTYGLIAETDINTEFIRWMGPARFELGVAFNIIQKKKYPCEIYVKYAAKSKNELKNHYLEHKNKGSLEFQHITMNKDNEDCDNYNYENEYETENEDEDEDADADDEDSHLISRDLADSSADQIKEEDFKIKYPLDEGIPSDWERLDPNISNNLGIFYTGKMPYVAADTKFFPAALPSDGTMDMVITDARTSLTRMAPILLGLDKGSHVLQPEVLHSKILAYKIIPKLGNGLFSVDGEKFPLEPLQVEIMPRLCKTLLRNGRYVDTDFDSM", "function": "Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance.", "AFDB_id": "AF-Q06147-F1-model_v4" }, { "swissprot_id": "Q9XW88", "sequence": "MISVMQQMMNNSNMPPPFVKSSDSHETHDESPTSPFIKRSDSPATTSSAAAAAMQHNFWSTRAAQLQQSVSGSSGVSSGSSSSASNNLSRTQADNHSERGSDTASSPQVAPLPTSSGMSMPAAAAAGMYPFNAGRFPTEFNMMVNQSMYNDFYSNSLAASSWPYSYPQQYPFANYSMPSLDGNLNDGGQLEWTSSSHAMRKKRKPYTKAQTLELEKEFLYNTYVSKQKRWELAKYLHLTERQVKIWFQNRRMKDKKQKQRTSGDPTGMLMPPGLD", "function": "Probable transcription factor, involved in posterior embryonic patterning, morphogenetic movements of the posterior hypodermis, and cell fate specification. May regulate expression of transcription factor dmd-3.", "AFDB_id": "AF-Q9XW88-F1-model_v4" }, { "swissprot_id": "P33301", "sequence": "MWVVRYQNTLEDGSISFISCCLQAFKTYSIGRSSKNPLIIKNDKSISRQHITFKWEINNSSDLKHSSLCLVNKGKLTSLNKKFMKVGETFTINASDVLKSTIIELGTTPIRIEFEWINEVWNIPPHLTQFRTMLSEYGISTEISINDIPANLMISDYPKSEDNSIRELYALVSTIPMKKSRFLMELCNTLLPTSKTNLKFDEMWNDMISNPEYNVFDFDPNILLSKFMRLNNIRVLTTIKSEPRLSSLLRTFNINLFAFDNIDSLYKYVDSLEASTEYLILTTTDKKENGKILCTIKTMLTSIIDGTLSAVINMKGASSRTLDNGKFDQISEGMSTILKTSRAPEVEASPVVSKKRKLNRRRVLPLDSLDFFAGGLSTKTLSENRSLTDAKRLNCGAESKTVISSPNIAEADEKHAPFLQNALKPTEDIGKKSGHSSPGAIIVSSPNLGTVNTSEDSLDKSLQSHKLPQPSLPEVAGIGSQTISSNSADYETAAVNSMDDAEVTKNFRVNHHQNIEQPSKNIRKLSNYSREISSPLQENCKSPVKELSIKEKSGTPHAFVEAIQETKNREVKRVKSTIVELKDEELSEEAINQLKNLAIVEPSNNLLRKSFDSEGNKTSRTTEKWENSLMEPEWHKRKNFKTFVKVRPKSKAHKEEGKNNTQSSDFIRNAAFLITRNYVPLKKYSKKDTTTKWGTEENEDMFALTEMERFGSNTFMSDNINSNTIQKRSQALNRFTNEDSSNEGEEDSFSFSRCSGTAASVQPLKNKIFITDEDDLGDIDDKSDRLNHRENNRNLFVVKEMNLRPNLSEECSKQSRHSRSATSRSRGSFGASNNGDGDDDDDDGPKFTFKRRKG", "function": "During meiosis is involved in homologous recombination and during vegetative growth it is necessary for DNA repair. It probably regulates the 5'-3' exonuclease degradation of double strand breaks either at the initiation stage or a later stage.", "AFDB_id": "AF-P33301-F1-model_v4" }, { "swissprot_id": "O28105", "sequence": "MKRVQNLLVAVGLSPNYHRRTYPSGKKSLVVRFYATLTPGLEDVAAKEVESFGCKVEEIRERRGRIFFSGEKSAIPLLNHFSRTLERLNVLLLRCEVEGLDDIYAAVKGLDFSFVKGKSFAIRSLRVGEHDFTSMDIARVAGQAVIDSFMESYGERLKVNLNQPDVIIRVELVDSELFVGVDTTGDDAMHKRWWRVYNHPAHLNAAIACGMLRIADWKVDESLIDPMCGSGTIPIEAALMVRNVPNLRDFAYKKLCEWELAFEPNEVRLKLYGMEKFRKHLVGAIRNAVNAGVADTIEFRQGDATEMTGEYDVIITNPPYGLRIHRKGAIERLYHSFARAAKRCMNQNSRLVIITAEHRVFANAAEEAGLQCTHERFVKYGGLLTKIMVFMI", "function": "S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the methylation of the guanosine nucleotide at position 6 (m2G6) in tRNA.", "AFDB_id": "AF-O28105-F1-model_v4" }, { "swissprot_id": "Q6BP70", "sequence": "MSRLTEDSIGDINLASTQMQGRLEEFDEISKEEENMKKRIERLRKFKNIDTNTNHTIGLQNENLENKNKDTSITKPKRRSKRDNNRIKSLTSLMEETYNKGKSFQELKQSKLGQKDAQLSIFQYFSGHKEKIGDILKRIESIEKRKLESSDVPEIEHESRILYTKKEWTDIIKRIRLRFPELSSRTKKSLKYITNKIQIQNQSQLISEYPKNNSSIWSQASAPPDTEFTDDDLKWLYDLTSEQIINESTILQNDLEESDNETPFVMTLSQVMNTTKSEDTIDREFDVISDSSPEPSPIRVSFCCRDEQSDKALHLSEQKIQVKNSIYDPEFNGNEIFSHQKDSVETAVSIESFPFVQSGQRESITGDIAEISEDNFQVSETAPRQPQAIHGTQEAPIEISSSSINRGKTNLMSEEDRASHNEAEEVIISSPIKDSELFKTPTKRTPGSKNIMSSPFRLHCNSSPLSIRSNSVTPRHERIVSEESSAYSTARSKFKLSSAQPIPSQYQFDDSEEEAIFSSMPARQAYKKRKVYHTSRLLIDGGLYVELMNENSKVKIKTIETKRQPVDSENEIRDSEDEGEHDNSLSVIEITREVDDTDDLVNLGRNPRNENDTSVLQVPSSPQIDNSNVLGSLYTSQAADSAFGSEKILEDPIRSNALELTQDEFNNMSTKDLKAKFQEWGLKPVKGKEKMIQILSETNKLVSQSQLNDSQDKPMTASQHTIKTNIYNRISFHLKQDQYWLDKILSFEPINLCMLQEWLASGSAGVKLETDILEKYCDELGITYTDIK", "function": "Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.", "AFDB_id": "AF-Q6BP70-F1-model_v4" }, { "swissprot_id": "P62848", "sequence": "MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE", "function": "Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.", "AFDB_id": "AF-P62848-F1-model_v4" }, { "swissprot_id": "P9WHU6", "sequence": "MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE", "function": "Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.", "AFDB_id": "AF-P9WHU6-F1-model_v4" }, { "swissprot_id": "O60094", "sequence": "MATKTQLELFTKLTSNDKAIRLSSAAQLIDSLSNEEELKYSLNRLTKGLSSGRESARIGFAVALTELLTRTKDIRATHVLDLLVKHNTASGNLKGQDERDFYFGLLFGLQSIVYSGILTHKESTIEDFQRVVDLLLQLSGKKNWLQDVCFYVIYKLVEQIPEISFSSNAFLAVNKLLQTPAVSKSTEGVGLFLCLTRVPDNVKSEEVAMANWEPAHPLHKSNLVTLSKIMRQADASETGGQNSAWKQKIPMVWKYIFEEYQRKTYSGLAPFHDFWAVVVDEGIFSSTSSLERKFWGFQIMELALDYVSSDNIGDIFSKNFLHCLINHLSDEDRYLYRAAKRVTSKLEKVSKQNPTLVYPIAIHLLGERGSLNFDRVTNTKLVEHILPLADEQGILQLFQLLLSYVKRCPEDIASDTKAVEWRRQWATDTMLSILRSKRSIKQEPWVRELLEIFIAYGYFEVPESEEVIPKFSEGTQNMFRLRLMSALSYLSSSAFQQSQTDHQLGDKNWPYVALNYLLELEKSPKNNLLISMDESVIEIVQKSLSVLHKVTKKIDKKAQHLQQLNAFQLLYSLVLLQVYAGDTDSIDVLEDIDNCYSKVFNKKSKRESTSNEPTAMEILTEVMLSLLSRPSLLLRKLVDMLFTSFSEDMNRESIHLICDVLKAKESVKDSEGMFAGEEVEEDAFGETEMDEDDFEEIDTDEIEEQSDWEMISNQDASDNEELERKLDKVLEDADAKVKDEESSEEELMNDEQMLALDEKLAEVFRERKKASNKEKKKNAQETKQQIVQFKVKVIDLIDNYYKTQPNNGLGFEFLIPLLEMILKTKHKVLEEKGQAVFRNRLSKLKWTEEKPSSKNVLEALKKVHVLCGKKASLGSTGSSISQLLLKLLADTPYLKEGVEVYLKSFLLWIQEPSKSHYNANIFHDFINWGAQQRLKHQQTSTAASSPQKTGHHENEKTNH", "function": "Plays an important role in the regulation of rRNA transcription. Binds to rDNA promoter fragments.", "AFDB_id": "AF-O60094-F1-model_v4" }, { "swissprot_id": "O64792", "sequence": "MLSLNQEVHGPKTSEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVALVFYIGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMFDSHLAK", "function": "Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.", "AFDB_id": "AF-O64792-F1-model_v4" }, { "swissprot_id": "O77564", "sequence": "MWNPLHETDSTSVAWRRPRWLCAGALVLAAGLFVLGFLFGWFIKSPNEAANISPQHNVKKAFLDELKAENIKTFLYNFTRIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTRPNYISIIDEDGNEIFNTSLFEPPPPGYENVSDVVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKILIARYGKIFRGNKVKNAQLAGAKGIILYSDPADYFAPGVQSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRLQIAEAVGLPRIPVHPIGYSDAQKLLEKMGGSAPPDDSWKGSLHVPYNVGPGFTGNFSTQKVKMHIHSDNKVKRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGKLKKEGWRPRRTVLFASWDAEEYGLFGSTEWAEENSRILQERGVAYINADSSIEGNYTLRVDCTPLMYSLVYNLTKELQSPDEGFEGKSLFESWNEKSPSPEFSGLPRISKLGSGNDFEVFFQRLGIASGRARYTKDWVTNKFSSYPLYHSVYETYELVEKFYDPTFKYHLAVAQVRGGIVFELANSVVRPFDCRDYAVVLRNYADKLYNISMNHPQEMKAYSVSFDSLFSAVKNFTEIASNFSERVQDLDKNNPILLRIMNDQLMFLERAFIVPLGLPDRAFYRHVIYAPSSHNKYMGESFPGIYDALFDIENKVDPSKAWGEVKRQISIAAFTVQAAAGTLREVA", "function": "Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.", "AFDB_id": "AF-O77564-F1-model_v4" }, { "swissprot_id": "B6D9A7", "sequence": "MPSPEHPSWLSTLLADTRPPPKLFAWSPANLDSPTAVKPDRADRGDFDPGKYPVDAPITTASEPVKRIYIVGPGNVGRLYASYMSRQRDALPITLVVHRKELLSQWVTSEGVVLADRGGKVTKNKQFDVEWWTESRPRYGPVREVADGEKLHNVFISTKADAGLGEADRLRRYLGRCSSVVFAQNGVSKLWAPYGPLYVASRYHADDAPSFSACVVNHGISAAGLFYSIHTSPSDAFIGPIFKGSAAPAHGQNKRRRLDDDFFTTYISSTPFLDTKHVSSGQLWIIQLEKLVLNAAINPLTTLLRCKTGQLFASYDSHDALTRVLDQLLWQASAVIQALINHDANIDMLTSYAETVHRLVPGSDDYGRNFANIRRKLTVRFSQPILKAKLYAFGLNIREHRSSMLQDAEAGRKTEIRDVNGWIVDMAEYLGLDLDVGIHRGLIELIEECVVLDKEELARRLL", "function": "Ketoisovalerate reductase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity. Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis. The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclization of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine.", "AFDB_id": "AF-B6D9A7-F1-model_v4" }, { "swissprot_id": "Q62028", "sequence": "MVQWLAMLQLLWLQQLLLLGIHQGIAQDLTHIQEPSLEWRDKGIFIIQSESLKTCIQAGKSVLTLENCKQPNEHMLWKWVSDDHLFNVGGSGCLGLNISALEQPLKLYECDSTLISLRWHCDRKMIEGPLQYKVQVKSDNTVVARKQIHRWIAYTSSGGDICEHPSRDLYTLKGNAHGMPCVFPFQFKGHWHHDCIREGQKEHLLWCATTSRYEEDEKWGFCPDPTSMKVFCDATWQRNGSSRICYQFNLLSSLSWNQAHSSCLMQGGALLSIADEDEEDFIRKHLSKVVKEVWIGLNQLDEKAGWQWSDGTPLSYLNWSQEITPGPFVEHHCGTLEVVSAAWRSRDCESTLPYICKRDLNHTAQGILEKDSWKYHATHCDPDWTPFNRKCYKLKKDRKSWLGALHSCQSNDSVLMDVASLAEVEFLVSLLRDENASETWIGLSSNKIPVSFEWSSGSSVIFTNWYPLEPRILPNRRQLCVSAEESDGRWKVKDCKERLFYICKKAGQVPADEQSGCPAGWERHGRFCYKIDTVLRSFEEASSGYYCSPALLTITSRFEQAFITSLISSVAEKDSYFWIALQDQNNTGEYTWKTVGQREPVQYTYWNTRQPSNRGGCVVVRGGSSLGRWEVKDCSDFKAMSLCKTPVKIWEKTELEERWPFHPCYMDWESATGLASCFKVFHSEKVLMKRSWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTQERQFWIGFNRRNPLNAGSWAWSDGSPVVSSFLDNAYFEEDAKNCAVYKANKTLLPSNCASKHEWICRIPRDVRPKFPDWYQYDAPWLFYQNAEYLFHTHPAEWATFEFVCGWLRSDFLTIYSAQEQEFIHSKIKGLTKYGVKWWIGLEEGGARDQIQWSNGSPVIFQNWDKGREERVDSQRKRCVFISSITGLWGTENCSVPLPSICKRVKIWVIEKEKPPTQPGTCPKGWLYFNYKCFLVTIPKDPRELKTWTGAQEFCVAKGGTLVSIKSELEQAFITMNLFGQTTNVWIGLQSTNHEKWVNGKPLVYSNWSPSDIINIPSYNTTEFQKHIPLCALMSSNPNFHFTGKWYFDDCGKEGYGFVCEKMQDTLEHHVNVSDTSAIPSTLEYGNRTYKIIRGNMTWYAAGKSCRMHRAELASIPDAFHQAFLTVLLSRLGHTHWIGLSTTDNGQTFDWSDGTKSPFTYWKDEESAFLGDCAFADTNGRWHSTACESFLQGAICHVVTETKAFEHPGLCSETSVPWIKFKGNCYSFSTVLDSRSFEDAHEFCKSEGSNLLAIRDAAENSFLLEELLAFGSSVQMVWLNAQFDNNNKTLRWFDGTPTEQSNWGLRKPDMDHLKPHPCVVLRIPEGIWHFTPCEDKKGFICKMEAGIPAVTAQPEKGLSHSIVPVTVTLTLIIALGIFMLCFWIYKQKSDIFQRLTGSRGSYYPTLNFSTAHLEENILISDLEKNTNDEEVRDAPATESKRGHKGRPICISP", "function": "Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis.", "AFDB_id": "AF-Q62028-F1-model_v4" }, { "swissprot_id": "Q7TQC7", "sequence": "MFGADGRPAIGTAAGKSWHFSRTMEELVHDLVSALEESSEQARGGFAETGEHSRNLSCPLKRQARKRRGRKRRSYNVHHPWETGHCLSEGSDSSLEEPSKDYREKHSNNKKDRSDSDDQMLVAKRRPSSNLSSSVRGKRLLWHESDFAVDSLGNRTLRRRRKVKRMAVDLPQDVSSKRTMTQLPEGCRDQDMDNDRASQYPEFTRKKVKKRKLKGIRPGPKTQEEGGVLESEERSQPNKDRMEYEEQKASDELRSESDTSSLSSTDAGLFTNDEGRQGDDEQSDWFYEKESGGACGIAGVVPWWEKDEPAELDTNLPDPVFESILSGSFPLMSHPGRGGFQARLSRLHGTPSKNIKKSSGAPPSMLSAPGPGSNKRMVHFSPDAHRHDHWFSPGARTEHGQHQLLRDNRAERGHKKSCSLKTASRQTSMHLGSLCTGDIKRRRKAAPLPGPTAAGIVGENAQPILESNIGNRMLQSMGWTPGSGLGRDGRGIAEPVQAVQRPKGLGLGFPLPKSSPTSPAPTSGNPA", "function": "Enhances the ATPase activity of DHX15 in vitro.", "AFDB_id": "AF-Q7TQC7-F1-model_v4" }, { "swissprot_id": "Q9C6V4", "sequence": "MRTKTKLVLIPDRHFRRATFRKRNAGIRKKLHELTTLCDIKACAVIYSPFENPTVWPSTEGVQEVISEFMEKPATERSKTMMSHETFLRDQITKEQNKLESLRRENRETQLKHFMFDCVGGKMSEQQYGARDLQDLSLFTDQYLNQLNARKKFLTEYGESSSSVPPLFDVAGANPPVVADQAAVTVPPLFAVAGANLPVVADQAAVTVPPLFAVAGANLPVVADQAAVNVPTGFHNMNVNQNQYEPVQPYVPTGFSDHIQYQNMNFNQNQQEPVHYQALAVAGAGLPMTQNQYEPVHYQSLAVAGGGLPMSQLQYEPVQPYIPTVFSDNVQYQHMNLYQNQQEPVHYQALGVAGAGLPMNQNQYEPVQPYVPTGFSDHFQFENMNLNQNQQEPVQYQAPVDFNHQIQQGNYDMNLNQNMKHAHIPFMDGNYYNYHQPPTVGLTSTGHMPSTTTTTTNNNNNNNV", "function": "Putative transcription factor.", "AFDB_id": "AF-Q9C6V4-F1-model_v4" }, { "swissprot_id": "P33203", "sequence": "MSIWKEAKDASGRIYYYNTLTKKSTWEKPKELISQEELLLRENGWKAAKTADGKVYYYNPTTRETSWTIPAFEKKVEPIAEQKHDTVSHAQVNGNRIALTAGEKQEPGRTINEEESQYANNSKLLNVRRRTKEEAEKEFITMLKENQVDSTWSFSRIISELGTRDPRYWMVDDDPLWKKEMFEKYLSNRSADQLLKEHNETSKFKEAFQKMLQNNSHIKYYTRWPTAKRLIADEPIYKHSVVNEKTKRQTFQDYIDTLIDTQKESKKKLKTQALKELREYLNGIITTSSSETFITWQQLLNHYVFDKSKRYMANRHFKVLTHEDVLNEYLKIVNTIENDLQNKLNELRLRNYTRDRIARDNFKSLLREVPIKIKANTRWSDIYPHIKSDPRFLHMLGRNGSSCLDLFLDFVDEQRMYIFAQRSIAQQTLIDQNFEWNDADSDEITKQNIEKVLENDRKFDKVDKEDISLIVDGLIKQRNEKIQQKLQNERRILEQKKHYFWLLLQRTYTKTGKPKPSTWDLASKELGESLEYKALGDEDNIRRQIFEDFKPESSAPTAESATANLTLTASKKRHLTPAVELDY", "function": "Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.", "AFDB_id": "AF-P33203-F1-model_v4" }, { "swissprot_id": "Q2JKS4", "sequence": "MSISLNYSATRDPLSALGLDVGNRRIGVAGSDRLGLLATGLGVIQRRSLSEDIAQVQEWIRRRQATVVVVGIPLLADGSVGSQARKVQRFVRALQVAVDLPIVTVNEYLSTAQAEWDLREAGIPAKAQKGLIDQQSAAVILQTWLDERRASLSEVPAWQSWGNKDYAGEV", "function": "Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.", "AFDB_id": "AF-Q2JKS4-F1-model_v4" }, { "swissprot_id": "Q9ZHV9", "sequence": "MRLGRRTSKQEEAQIDLTSMLDIVFIMLIFFIVTSSFVRESGVEVNRPTAAHAVSQKQAGIFVAITAANDIYIDKRQVDVERVQATLEHLLLDQPDASLVIQADEHAFNGTVVKVMDAAKGAGVKSIALAAEKP", "function": "Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.", "AFDB_id": "AF-Q9ZHV9-F1-model_v4" }, { "swissprot_id": "P11901", "sequence": "MNYSHDNWSAILAHIGKPEELDTSARNAGALTRRREIRDAATLLRLGLAYGPGGMSSLREVTAWAQLHDVATLSDVALLKRLRNAADWFGILAAQTLAVRAAVTGCTSGKRLRLVDGTAISAPGGGSAEWRLHMGYDPHTCQFTDFELTDSRDAERLDRFAQTADEIRIADRGFGSRPECIRSLAFGEADYIVRVHWRGLRWLTAEGMRFDMMGFLRGLDCGKNGETTVMIGNSGNKKAGAPFPARLIAVSLPPEKALISKTRLLSENRRKGRVVQAETLEAAGHVLLLTSLPEDEYSAEQVADCYRLRWQIELAFKRLKSLLHLDALRAKEPELAKAWIFANLLAAFLIDDIIQPSLDFPPRSAGSEKKN", "function": "Involved in the transposition of the insertion sequence IS421.", "AFDB_id": "AF-P11901-F1-model_v4" }, { "swissprot_id": "P02930", "sequence": "MKKLLPILIGLSLSGFSSLSQAENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDANGINSNATSASLQLTQSIFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQYDTVLANEVTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGISDTSYSGSKTRGAAGTQYDDSNMGQNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQELANARYNYLINQLNIKSALGTLNEQDLLALNNALSKPVSTNPENVAPQTPEQNAIADGYAPDSPAPVVQQTSARTTTSNGHNPFRN", "function": "Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.", "AFDB_id": "AF-P02930-F1-model_v4" }, { "swissprot_id": "O32348", "sequence": "MKVSSTGGVSATGASRAKPAGGSSGFSLPSVNAASGAASTASVGGLTGVGSVDALLALQAAGSVGGPLERRKRAVRRADNILDILGEVRIALIDGDISHATLDRLSRAIREQREATDDPRLEGVLNEIETRAAVELAKLQARAG", "function": "Required in an early step of flagellar assembly.", "AFDB_id": "AF-O32348-F1-model_v4" }, { "swissprot_id": "Q9FI46", "sequence": "MGTESGSDPESSSNGWSRARGLVVKTLVLIGGALLIKRLTKSTTRRDHARVVSRSLTGEKFTREQASRDPDNYFNIRMLSCPAAEMVDGSEVLYLEQAFWRTPQKPFRQRLYMVKPCPKELKCDVEVSSYAIRDAEEYKNFCDRPKDQRPLPEEVIGDIGEHLTTIHLNCCDRGKRCLYEGSTSPGGFPNSWNGASYCTSDLAVLKNNEIHLWDRGFDENRNQVWGPKEGPYEFKPATSSSINENLSALNILYQSSIDKPIQGSLILQD", "function": "Confers sensitivity to cabbage leaf curl virus (CaLCuV), probably by supporting viral movement.", "AFDB_id": "AF-Q9FI46-F1-model_v4" }, { "swissprot_id": "Q6FIU0", "sequence": "MLARSAASLSTTAATTQSNMSVTSQFMDANDCKFIVYKASQIRLTEMKRLLGVLVPNLKKRSSQNKNIVPLVTYMLPLLAGPVLNVNAALKEKYNQIVQGQEPTKDNKDYDVTPRDWLTYVMDSNTQNQPLEGCELVEFKKELYDKDKQWLTVTRLLKLIDEVISTYNNKFKSANLLKKTYSKSIEDLIKPSELSLCLDLAVLITDYERDTSEASFRKLQWQVIEKFLATLHSKVEPTLKTYYKSLLAYQSGKLMLYKLPFPEWTIHRMFAFTVRMISLMKLFGCELRVLYYPNRKYLNDLKTKLVCENVYKYDLLITQIEKLCADPLYQIKESKEMMQFFQKYPYSLPKSLPQKTHEFFIKKVISTCINHWNNNTKLVEDWVEMWKFCDKNNSAKEKIESSNEEQLIKMYDERYTVDKLVYLEHEEERAKLSNKKSIGIVVKSSSSSSPNKLLRKLSPISGMAKPKVRSTKSPASSSSSNSNSNSALSSGMATPKERSRRSSVDRGLPKGGRLPGLTKTNTNERLVAPLIHISETSSVSNSGSSSINASPLGSRRGSIKDESAARKMVINRTVERTRSKIGNRPRSASLQSNESAALNSVGIVGSPLSNNRLPKPVSNQSQLRSNSLESNSALNRKMVQDTFKHLMANNPKPSNLSHSPTSSPMRPSSPIPSRSNSNKVSSTNNGAILSPEPKGKSKANNSNDKIKTNGVTSINIDNSDNEIVLKPLPHESKDTTTGPVRPVDESVNNLSEGTPAGSESTPESMKSAVGIEGLDKENLNVESGNMESGEPSKKVRFVGVPPMTEAENPKPTRKGWYKKPAVLHYPPVPQQVTMFRDRLRQEGMVFRTSLRDTVAATSNEVGKKGGMMLSLAIDNPPVKEISSHSRFASKLREKLTR", "function": "GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.", "AFDB_id": "AF-Q6FIU0-F1-model_v4" }, { "swissprot_id": "Q12449", "sequence": "MVVNNPNNWHWVDKNCIGWAKEYFKQKLVGVEAGSVKDKKYAKIKSVSSIEGDCEVNQRKGKVISLFDLKITVLIEGHVDSKDGSALPFEGSINVPEVAFDSEASSYQFDISIFKETSELSEAKPLIRSELLPKLRQIFQQFGKDLLATHGNDIQVPESQVKSNYTRGNQKSSFTEIKDSASKPKKNALPSSTSTSAPVSSTNKVPQNGSGNSTSIYLEPTFNVPSSELYETFLDKQRILAWTRSAQFFNSGPKLETKEKFELFGGNVISELVSCEKDKKLVFHWKLKDWSAPFNSTIEMTFHESQEFHETKLQVKWTGIPVGEEDRVRANFEEYYVRSIKLTFGFGAVL", "function": "Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Binding to HSP82 promotes a conformational switch in the catalytic loop of HSP82, facilitating the interaction of the catalytic 'Arg-380' with ATP in the N-terminal nucleotide-binding domain. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting.", "AFDB_id": "AF-Q12449-F1-model_v4" }, { "swissprot_id": "O32034", "sequence": "MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADAVFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKALGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLARETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDYDLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVATVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHAKKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGNELDAARHPLQIVKFKLDKKIYPSNMMRKGK", "function": "Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-methoxyuridine (mo5U) biosynthesis.", "AFDB_id": "AF-O32034-F1-model_v4" }, { "swissprot_id": "O42720", "sequence": "MLFSKVIAPAFILLGAASAAPGGLAPENASKRDQPSVGDAFDKYNEAVRVFTQLSSAANCDWAACLSSLSASSAACIAAVGELGLDVPLDLACAATATSSATEACKGCLW", "function": "Involved in calcium binding and uptake in yeast phase. Required for growth in limiting calcium conditions and for yeast survival in host macrophages. Is able to bind a variety of lipids.", "AFDB_id": "AF-O42720-F1-model_v4" }, { "swissprot_id": "O42912", "sequence": "MEEFTLDRNSNVGNLIALAVLNKFDELARHGKPIIRANGVREWTTLAGVVIQKKMENEFICVCLATGVKCTPAGIIKNEQLGSVLHDCHAEILALRCFNRLLLEHCILIKESKKDTWLLEVADNGKFTLNSNLLIHLYVSECPCGDASMELLASRLENNKPWNLTVDSEKLMRGRADFGLLGIVRTKPGRPDAPVSWSKSCTDKLAAKQYLSILNSQTSLICEPIYLSCVVLYKKVIVKSAIDRAFGPFGRCAPLAEFGEKDNPYYFHPFTVLETDENFLYSRPLNQAEKTATSTNVLIWIGDKMQCTQVIHNGIKAGTKAKDVEKSQTLICRKSMMNLLHQLSQSLTNEKNYYEWKKLNIKRCQQKQILRNILKNWIPNGGNEFQWI", "function": "Deaminates adenosine-37 to inosine in tRNA-Ala.", "AFDB_id": "AF-O42912-F1-model_v4" }, { "swissprot_id": "P47064", "sequence": "MIHAVLIFNKKCQPRLVKFYTPVDLPKQKLLLEQVYELISQRNSDFQSSFLVTPPSLLLSNENNNDEVNNEDIQIIYKNYATLYFTFIVDDQESELAILDLIQTFVESLDRCFTEVNELDLIFNWQTLESVLEEIVQGGMVIETNVNRIVASVDELNKAAESTDSKIGRLTSTGFGSALQAFAQGGFAQWATGQ", "function": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.", "AFDB_id": "AF-P47064-F1-model_v4" }, { "swissprot_id": "O97472", "sequence": "MTSIKISSDVFNKYHTNGKLRLSTGYVQEALEKQGYPGHDGVVQILKGKEDIGEQMGHGFTYRIRICDGIFQYNTLVSADIDDQIKREAEHLVEGAIIAITNLSTFSQGAGIKTSFLITGYTLLSRYHQTLSAPEVKPRSHSGNPAEHHGYRPNIVVEDVWPEAESITSEFQENMSNPPAAKMPKRESGGEASHNRVPAPEPHRSRAPPPPARRGPSNTERGVIPIAMVTPYVNNFRIHGMVSRKEDIKNIPAKNMKIFNFEITDSNGDTIRCTAFNETAESFHSTITENLSYYLSGGSVRQANKKFNNTGHDYEITLRNDSVVEAGGELLAAPKLNLKRVSLAEIAGHCGEMIDVLVIVEKMDAEATEFTSKAGKTLTKREMELIDESQALVRLTLWGDEAIKANVDDYHGKVIAFKGVIPREFNGGYSLGTGSGTRIIPVPEISGVSELYDWYTTEKPHSELKLISQTSGGMSEAPRTIAGLQEMQFGKDSDKGDYASVKAMITRINPNSALYKGCASEGCQKKVIESDGEYRCEKCNKSMNKFKWLYMMQFELSDETGQVYVTAFGDSAAKVVGKTAQEVGDLKDENLNEYNATFERLQFVPKMWRLRCKMETYNEEVRQKMTVFSVEEVNQDKYIENLKELIEQMKGIEDEGSY", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.", "AFDB_id": "AF-O97472-F1-model_v4" }, { "swissprot_id": "A0A0U1LR74", "sequence": "MEEELEPLNRPTLDPDESYAEEKIYGSSHREPNSRIRVFVSLLILSNTISFGLLGWIGLSSTQASLAIPEDYAIPPRIATQYKRFWWTTEYSSKNQSQQDELWNSIVWTYGMIGVDHEWSKSQHWPDTMSLPQDKTKAVYLLQAYHEIHCLGVLRRLMSQSLAGVDFSESEHTHAHIAHCFDSLLQSTICRADSTPLYTFGGTIVGSGQQHECRDWNALRDYATQNSACYTEESGFGGQCSDGDGLVPATPMETQQDGFWL", "function": "Part of the gene cluster that mediates the biosynthesis of the mycotoxin cyclochlorotine, a hepatotoxic and carcinogenic cyclic chlorinated pentapeptide. Cyclochlorotine is formed by the nonproteinogenic amino acids L-2-aminobutyrate (2Abu), L-beta-phenylalanine (beta-Phe), the unique L-cis-3,4-dichloroproline Pro(Cl(2)) and two L-serines (Ser). The condensation of the 5 building blocks is performed by the cyclochlorotine synthetase cctN, a nonribosomal peptide synthetase. The assembled linear pentapeptide is then assumed to be released through cyclization by the terminal condensation-like domain of cctN. Incorporation of the alternative substrates allo-threonine or alanine by the domains A3 or A1 respectively may lead to the production of the variants hydroxy-cyclochlorotine and deoxy-cyclochlorotine, respectively. CctP probably acts as a phenylalanine aminomutase and provides the uncommon building block beta-Phe. Furthermore, 2Abu can be synthesized from threonine by one of the threonine dehydratases and transaminases localized outside of the cluster. The biosynthesis of the unusual dichloroproline moiety remains elusive since the actual halogenase still awaits to be detected, with the possibility that proline halogenation is accomplished by a so far unknown type of halogenase. Finally, the cluster encoded transporters cctQ and cctS are most likely responsible for cyclochlorotine secretion and thereby may contribute to intrinsic resistance. The functions of the remaining proteins encoded by the cluster (cctM, cctO, cctR and cctG) have not been identified yet.", "AFDB_id": "AF-A0A0U1LR74-F1-model_v4" }, { "swissprot_id": "Q9FK47", "sequence": "MYYHNQHQGKSILSSSRMPISSERHPFLRGNGTGDSGLILSTDAKPRLKWTPDLHERFVEAVNQLGGGDKATPKTIMKVMGIPGLTLYHLKSHLQKYRLSKNLNGQANSSLNKTSVMTMVEENPPEVDESHSESLSIGPQPSMNLPISDALQMQIEVQRRLHEQLEVQRHLQLRIEAQGKYLQSILEKAQETLGRQNLGAAGIEATKAQLSELVSKVSADYPDSSFLEPKELQNLHHQQMQKTYPPNSSLDSCLTSSEGTQKAPKMLDNRLGLRTYIGDSTSEQKEIMEEPFFHRMELTWAEEESLRENHNRPYLSTMVNNAEPRISSSRRSPGRLSIGVGLHEHRGRSSNNSEYTEERFNENNEDCKLETHTRTALDLNTHDENYGTTRPKQFDLNGFSWN", "function": "Transcription factor that may act on the GAL1 promoter. Acts redundantly with MYR2 as a repressor of flowering and organ elongation under decreased light intensity. Represses gibberellic acid (GA)-dependent responses and affects levels of bioactive GA.", "AFDB_id": "AF-Q9FK47-F1-model_v4" }, { "swissprot_id": "Q02651", "sequence": "MACTNDGPNKYPEIVSVKHLFQHSGSKHEFSAGKRFSKSIGKIFKRNSALKTSRTETANHKMELKKREGVTLLPPVPESLLHKLNSWLETFSSTKNMKIEENKIVINEKEIRDSVSYYPDKNGGSAVFCYLPDLVLYYKPPIKVTGKQCPIKRSPWESMEIQYQKFMYPLERLERQFEEVPFRPWYFAMRLKELYRCCERSFTNAANRGKARLLRGKQRTKKSYHKTVNLVSAKISTHSNAPSPG", "function": "Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane.", "AFDB_id": "AF-Q02651-F1-model_v4" }, { "swissprot_id": "Q6ZSG2", "sequence": "MVSKDTGKCILTTSESEVEPAACLALEMKYALDPNRQIKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKPVSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGNLKSLPAADPFKSQNNGFLTDAKEKNEAGPMEEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPEPLSYGEAALQNSTRPPSEEPDYQLLGRAKQDRGRPNSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCPADDERRRATHLNGLQAPSETALACSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQELEKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKTESKKHGRWKLWFL", "function": "Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.", "AFDB_id": "AF-Q6ZSG2-F1-model_v4" }, { "swissprot_id": "Q7SB74", "sequence": "MSIFNQKSKFKIKTEIRTVRETVERPKLKASTSSSSIPTTGSSQHSNVRIAGAGSSLSRASSTPRLNGTSHTTSTSSSARASLTKVTTIPTARRIQSASPIPSINGDGRSSRKRRAIKASSRSPISPHFSEDSDSDSNGDENWEDNLDARKRRKRVHDERPVDVNRKLRHPKIWKGEEADQVERIPGPAIIHAAKVASLEHKCKPALGLKNEEVAVRLQYPGARYPERYELVEGKDKIDAVKDIEKVVQLAASTYLTDEEGKIFLDHQTGILRKLVKSKNRSDGPGFKAALREYNDEFLKLMRKGVIVRNLDKMHGIPRELVDFILDQVYDRTVAPRVELLAKYQNGSDNVYGELNHPFISDILERTNLTSDKVFVDLGSGVGNVTLQAALEIGCESWGCEMMENACNLAEAQYDEFLARCRLWGVKPGKVRLERGDFRKNEKILEVLKRADVVLVNNQAFTSQLNDNLVSMFLDLKIGCKIISLKTFVHDNKNAENDVATSILDVEHLTYPEGYVSWTGASGTYCISTRR", "function": "Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.", "AFDB_id": "AF-Q7SB74-F1-model_v4" }, { "swissprot_id": "Q9CA90", "sequence": "MESIGVLMMCPMSSYLENELEKRFNLLRFWTSPEKSVLLETHRNSIRAVVGNASAGADAQLISDLPNLEIVSSFSVGLDKIDLGKCKEKGIRVTNTPDVLTEDVADLAIGLILALLRRLCECDRYVRSGKWKQGEFQLTTKFSGKSVGIIGLGRIGTAIAKRAEAFSCPINYYSRTIKPDVAYKYYPTVVDLAQNSDILVVACPLTEQTRHIVDRQVMDALGAKGVLINIGRGPHVDEQELIKALTEGRLGGAALDVFEQEPHVPEELFGLENVVLLPHVGSGTVETRNAMADLVVGNLEAHFSGKSLLTPVV", "function": "Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate (HP) into glycolate and glycerate in the cytoplasm, thus providing a cytosolic bypass to the photorespiratory core cycle. Mostly active in the presence of NADPH and hydroxypyruvate.", "AFDB_id": "AF-Q9CA90-F1-model_v4" }, { "swissprot_id": "Q6IP18", "sequence": "MWNNHGGFDGGYGGSGMGGGGGYMQSPGGFGSPAPTQGEKKSRSRSQQIVPCTVSQLLSATQNDEVFRIGEAELSQVTIVGIVRHAEKAPTNILYKVDDMTAAPMDVRQWVDTDEASCENMVVPPGSYVKVAGHLRSFQNKKSVVAFKIAPVEDMNEFVSHMLEVVHAHMAMNSQGAPSGGGSTVALSTPGRVGDSGRAFSGGNDNPTNGLTPHQSQILSLIKSCKGNEGMAFEELKNRLHGMNVNTIRQAVEFLSNEGHIYSTIDDEHYKCTDGD", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.", "AFDB_id": "AF-Q6IP18-F1-model_v4" }, { "swissprot_id": "Q5TXN1", "sequence": "MNPVVCAFGVIFVVVTLELVVAHPGKDVLGCHNGTSITVDECCAIPMLANKTVIEKCKAAHPFKPPQNTDDKGPRGHPGECIAECIMKGMGALKNEKVDGPAFRKAIEPVVKANPAFAKLLDDTVKQCHESINVDSEFTRYVTKPVCKADAKAFINCVYGTLFEQCPTNVWTQKDGCTQLKDKIKKGCAYFALRKHGGRRMRPT", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.", "AFDB_id": "AF-Q5TXN1-F1-model_v4" }, { "swissprot_id": "O83664", "sequence": "MEIQTKTLGTQTVEAHQIITLERGLYGFEKYHRFALFDAVQVPFIHMQSLDDPALSFIAIDPFLFRPDYELDIDDVLLQPLDISSPTDVLVFALVTIPPDGSAVTANLQGPLIVNKKNRKAMQVAMGGDRWRTKHDIVAEMAERRAQEQC", "function": "Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum.", "AFDB_id": "AF-O83664-F1-model_v4" }, { "swissprot_id": "P31708", "sequence": "MKIAGKWKRKAAKAPLHRGTVARHPCLIVRLPVEEQGEIEWQVRSSNGESLLSQGRGSIEQVRPALAAYPSVTFTRVLVPATDVTFYALTLPRQARRHVTQVVPFMLEDQLATEIEKLHFAVLEIHGDDGTVAVVEKNRMQRWLAQCDALGLSVDTLLPDARVLPKHQDGWSALQHDDMWLFRQPTGHAMAAESSWCGDLLKASMPLPAIYSYSAASVGGELAQYEWQEEGEWKAQPETDLFTLAATAHLPASVDLRQGDYAPDKAWQNTLLPWRGVGIAFACYLLLVVADAGWAHYQLYQQAEHWRQESVRVYRQIFPSETNVVNPRAQMQQHLQRTAAGGAGKALLDQLTPLQQLMTQNSAIKIQSLSYDGAAGEFRLALQGTSYQELEQFQQQAAAYYQVQAGEMRQENDRVEGRLTLRSQQ", "function": "Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Plays a role in the complex assembly and recruits OutM resulting in a stable complex in the inner membrane. Provides thus a link between the energy-providing OutE protein in the cytoplasm and the rest of the T2SS machinery.", "AFDB_id": "AF-P31708-F1-model_v4" }, { "swissprot_id": "P43870", "sequence": "MKKSALEKLLSLIENLTNQEFKQATNSLISFIYKLNRNEVIELVRSIGILPEAIKPSSTQEKLFSKAGDIVLAKAFQLLNLNSKPLEQRGNAGDVIALSKEFNYGLVADAKSFRLSRTAKNQKDFKVKALSEWREDKDYAVLTAPFFQYPTTKSQIFKQSLDENVLLFSWEHLAILLQLDLEETNIFSFEQLWNFPKKQSKKTSVSDAENNFMRDFNKYFMDLFKIDKDTLNQLLQKEINFIEERSLIEKEYWKKQINIIKNFTREEAIEALLKDINMSSKIETIDSFIKGIKSNDRLYL", "function": "A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-AAGCTT-3' and cleaves after A-1.", "AFDB_id": "AF-P43870-F1-model_v4" }, { "swissprot_id": "B0BCM3", "sequence": "MKTRSEIENRMQDIEYALLGKALIFEDSTEYILRQLANYEFKCSHHKNIFIVFKYLKDNGLPITVDSAWEELLRRRIKDMDKSYLGLMLHDALSNDKLRSVSHTVFLDDLSVCSAEENLSNFIFRSFNEYNENPLRRSPFLLLERIKGRLDSAIAKTFSIRSARGRSIYDIFSQSEIGVLARIKKRRATFSENQNSFFDAFPTGYKDIDDKGVILAKGNFVIIAARPSIGKTALAIDMAINLAVTQQRRVGFLSLEMSAGQIVERIIANLTGISGEKLQRGDLSKEELFRVEEAGETVRESHFYICSDSQYKLNLIANQIRLLRKEDRVDVIFIDYLQLINSSVGENRQNEIADISRTLRGLASELNIPIVCLSQLSRKVEDRANKVPMLSDLRDSGQIEQDADVILFINRKESSSNCEITVGKNRHGSVFSSVLHFDPKISKFSAIKKVW", "function": "Required for growth within mammalian cells.", "AFDB_id": "AF-B0BCM3-F1-model_v4" }, { "swissprot_id": "P83472", "sequence": "MKLLFAIVALLALAFLCADISAVKTSWPELVGETLEEAKAQILEDRPDAVIKVQPEHSPVTYDYRPSRVIIFVNKDGNVAETPAAG", "function": "Inhibits L.terrestris digestive chymotrypsin LT_CH 1 and bovine alpha-chymotrypsin.", "AFDB_id": "AF-P83472-F1-model_v4" }, { "swissprot_id": "Q8K3A6", "sequence": "MGRAREMGWMAAGLMIGAGACYCMYKLTMGRSEGNELEDEEEDEWEDGQDLDEEEADNWFDFTAMARPWSEDGDWDEPGAPGGTEDRRSGGGKANRAHPIKQRPFPYEHKNIWGEQSFKSFTCILDLNKCVSTQRKKRFTKNINAGFSLSPNISKHLASLSVVGNRSPTPHPTVREKALFVPENPNSSLENQGQIKMSIDEVCRETLLCCCKSFLQQAGLSLLISMTVINNMLAKSVSDLKFPLLSKGSGCAEVRGLEELMSLSEKPVLVGEALAAQMLSSFMCLFTRSGSREMLVEAISP", "function": "May regulate the dynamics and distribution of mitochondria in neural cells.", "AFDB_id": "AF-Q8K3A6-F1-model_v4" }, { "swissprot_id": "Q9KMG5", "sequence": "MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQWVDGVALNTYLDPHKY", "function": "Toxic component of a type II toxin-antitoxin (TA) system. Inhibits translation by cleavage of mRNA.", "AFDB_id": "AF-Q9KMG5-F1-model_v4" }, { "swissprot_id": "Q5ASR2", "sequence": "MGASTKRKKEKQKDFQKPKLKVGKAKAKPDNFTDTSFKSKAITLNQQSLTLTAPSANTQFSHHLSLLSSKSDSQRRDSLAHLTTTLTSQPTHLPPPQPVSVILPSLLPLILDSNASVRANLLKLLRALPQHDVKDHVGTLMPYIRAGMTHLAAEVRVSSVEVLGWLVSIAGDEVVGVAGGWVKTLNCFLSVLGWHVAAKSKWTSLATSTSTSASGSGNGTGSSTSGKASYGKAGAKGRPQVRFLTILADFLDAGIGSSGSQSMDTTADSASESENQYCTFPITTFASHLIPSNFASPYLTLNLFGTPRDEEGEMYETREDRWRVFVARGFLGAVERGLETARGEGGEVGRVSALAAKVLRNARDDLEGDGFGDEL", "function": "Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.", "AFDB_id": "AF-Q5ASR2-F1-model_v4" }, { "swissprot_id": "G3XD43", "sequence": "MRTRQKGFTLLEMVVVVAVIGILLGIAIPSYQNYVIRSNRTEGQALLSDAAARQERYYSQNPGVGYTKDVAKLGMSSANSPNNLYNLTIATPTSTTYTLTATPINSQTRDKTCGKLTLNQLGERGAAGKTGNNSTVNDCWR", "function": "Essential component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. May stabilize interactions between the major and a minor pilin subcomplex required for efficient pilus biogenesis.", "AFDB_id": "AF-G3XD43-F1-model_v4" }, { "swissprot_id": "A9A059", "sequence": "MDAVTGIILAGGESRRFGGGNKAFRMLDGRTMIDRVHDTVKSVCDDMVIVANTPLDYLGWNAVLATDLFDFRGSLVGIHAGLMSAGHEYAFISACDTPFLKQAVIKTIIGGIEDHIDVVVPEKKEGMEPLCAVYSRRCLEVIERHLHQGRMVIKAVYNKLRVRTISEKRLRAVDPDLVSFWNINTKEELEKAEAAIKAGRIS", "function": "Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.", "AFDB_id": "AF-A9A059-F1-model_v4" }, { "swissprot_id": "B2J056", "sequence": "MGIMGTFLLLAAEANAVHSELAEGAAEGGFGLNLDIFETNLINLAILVGILFYFGRKVLSNILNERQSNIATAIQEAEGRLKEAKTALSQAQEQLKQSQAEAERIRQSAVENAQKAKEALLAKAVQDVERLKQTAAADLNTETERAIAQLRQRVATLALQKVESQLKGGIADDAQQSLIDRSIAQLGGNV", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-B2J056-F1-model_v4" }, { "swissprot_id": "Q3TPR7", "sequence": "MPCACNRSNWRRWIRPLLVLFYATTILVAVPICIWKFQKMKVGMHTKSWFIAGIFLLLTIPVSLWGILQHLVHYTQPELQKPIIRILWMVPIYSVDSWVALVYPKIAIYVDTWRECYEAYVIYNFMIFLTNYLTIRFPNLILHLEAKDQQNHILPLCCCPPWAMGEMLLFRCKLGVLQYTVVRPITTVTALVCEILDVYDEGNFGFSNAWTYLVILNNLSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVLIALLVKLGVISEKRTWEWQSAEAVATGLQDFIICIEMFFAAIAHHYTFSYKPYVHEAEEGSCFDSFLAMWDVSDIRDDISEQVRRVGRTMRGYPKKKCFPGDPDHNEHSSLLSSSSQDLTSGSSKVPSPGGLYQGFGHTISSQSPISIASIYEEIMNDIPEEQQKLLNPGQDVTINIPEEQQKLIDKRKDVMIDIPEQNAIPDNSQYQDQEQIVTLQALFPSTETSENSMIDTSESQQESSDLCTESSDSSTESSDLSTDP", "function": "Possible tumor suppressor which may play a role in cell growth.", "AFDB_id": "AF-Q3TPR7-F1-model_v4" }, { "swissprot_id": "Q55EX7", "sequence": "MSSEELPSCGINDNDINNTIPINTRKVQIIPNGNTQCVKCLYNVANNVKDKKLSKKEKKEQKLKEEENNNNNNEEPITQQQKPIGKPIINFRSEQLCWECYRELILKKFKLNIVKVRESKRDAEKLLVALSGGTCSSMLLELLKQCTEGSGKAKMFLDIKCVHIDESSITPYQNHNDTIEFLKEFNNVKLGFPNLEIIPLEDILGTVTPLGERTNQLKLQFAQLSSETSKEDLLLYYRNQLLIQVAHKLNCKKVILGTSSNRLAVQLVASTSKGRGFSVPNETSVIIEQPSNDIKFYQPMRDFLLKEIFIYYRHLNILPVPVMFSILNLKPKHSINTLCEDFLHCLQDISNQTVHTLLRSVDKLISPSIDSNYNCSICSSPLTSAEIKSLEKVILDNNNNINKENKNNNNNNNNNNNNNGCCSTTKTEDSSCCNKTEDNSSNNNNNNTGCCSSSSSTSTSSITVNKETLCYSCKILYRDFKSTPNIAPYIKENSKQLLTTSQLKNEIKDFLLNSDDDDDDEDN", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.", "AFDB_id": "AF-Q55EX7-F1-model_v4" }, { "swissprot_id": "Q6N043", "sequence": "MGDNPFQPKSNSKMAELFMECEEEELEPWQKKVKEVEDDDDDEPIFVGEISSSKPAISNILNRVNPSSYSRGLKNGALSRGITAAFKPTSQHYTNPTSNPVPASPINFHPESRSSDSSVIVQPFSKPGYITNSSRVVSNKSSELLFDLTQDTGLSHYQGGPTLSMAGMSESSFLSKRPSTSEVNNVNPKKPKPSESVSGANSSAVLPSVKSPSVTSSQAMLAKGTNTSSNQSKNGTPFPRACPKCNIHFNLLDPLKNHMKYCCPDMINNFLGLAKTEFSSTVNKNTTIDSEKGKLIMLVNDFYYGKHEGDVQEEQKTHTTFKCFSCLKILKNNIRFMNHMKHHLELEKQSSESWENHTTCQHCYRQFPTPFQLQCHIESTHTPHEFSTICKICELSFETEHVLLQHMKDNHKPGEMPYVCQVCNYRSSSFSDVETHFRTSHENTKNLLCPFCLKVIKIATPYMHHYMKHQKKGIHRCTKCRLQFLTCKEKMDHKTQHHRTFIKPKQLEGLPPGTKVTIRASVGPLQSGASPTPSISASASTLQLSPPRTKNITAKNPAKSNTSKPNTVKSNASKPNTSKPNGSKSKYKPKISNMQKKQSTLASSNKKSKVNTALRNLRYRRGIHKCIECCSEIKDFANHFPTYVHCSFCRYNTSCSKAYVNHMMSFHSNRPSKRFCIFKKHSENLRGITLVCLNCDFLSDVSGLDNMATHLSQHKTHTCQVVMQKVSVCIPTSEHLSELKKEAPAKEQEPVSKEIARPNMAERETETSNSESKQDKAASSKEKNGCNANSFEGSSTTKSEESITVSDKENETCLADQETGSKNIVSCDSNIGADKVEKKKQIQHVCQEMELKMCQSSENIILSDQIKDHNSSEARFSSKNIKDLRLASDNVSIDQFLRKRHEPESVSSDVSEQGSIHLEPLTPSEVLEYEATEILQKGSGDPSAKTDEVVSDQTDDIPGGNNPSTTEATVDLEDEKERS", "function": "May function as a transcription factor.", "AFDB_id": "AF-Q6N043-F1-model_v4" }, { "swissprot_id": "Q9VKK1", "sequence": "MLIALFALAHLPIFRKTPLSASSSPPPSVHRSPRCGKASTAYHPPPADACISITASAIDAASGMSNSAEQDKPIAANGNAAEPQEIEVIHFQAQEKQCCRVIRSNKTKVLTSGGVHTRGSSKVKLKNIVDYKWERKYYYPGHLVAVHRDGKHLAYAINVNNKATGMEGMVRVCNIATSMRALIKGMSGEVLDLQFAHTDCERILAVIDVSSLFVYKVDQIEGNLLCNLVLKVEDPIANYVPEYDMVSWCPYVCSSSATVPINDDDDENQLLIWSRSSQFQCFQVKMIVSEHGRGKIQPAALESGYLKIEEDSLITCAALSPDGTTVAAACADGLVRFYQIYLFDVRNHRCLHEWKPHDGKKVCSLFFLDNINKPVEESYWQHVITTSDANTEIKLWNCSLWKCLQTINVVASPSSLQPRNFIAGIDRSANYLVLSCLDSLAVYVMQIGSTGGADSENRSSDSEGEGCDTSKRIQNVAEFKLSSGILSFSIVNASMRRVKNSIESYYPIEEPDDFDDDSNSTSALVLHMFVVQAKSLQECQIIYQPCVAEKTERSSLNSKRSQTPEDNLLIKEEPESPNSGTVGAVQLDALFAKSAKRASTGSSSAMVAVAAAAAAAPSAILQDATKEAAKSESPQLSSAYTQQVNLMTPDAFSASGTAAAAAVFVSTSTTTSIGTDSSTTTSGQDRSIDSAVLQTIRMLATVTSKTSENPNAEVLLNLMNNTLIEDREQQKLKEKLDARKKFIAIDRNPERNVAENLASGSSSPSREVQEIMATQDDADAYEAELENLDDDDDDEEEELANSSPLPEAVDGTWPIVKLSSHSAELQNAAQIMSQAVQNTNNGNVPPTLGGGHNNNTSVGSNSNNNTATTLSTSNTSSSNNAGGTCVDSSGTGELNAKMELLIDLVKAQSKQINKLENEVNKLQKQQEAAAALHSKQDTSLEPKNLSQLAYKIEMQLSKLMEQYLKRYENEHKKKLTEFLAARESQNRELRDSVLQVLNQYVMNHFTDIIGNVLNMELQRQLLPRVNANMDQLQAQMQVEIVQKLSVFDKTVKENIAQVCKSKQFLDTFGKSVLIGVQTSLQTAFIESMSSTLIPAYEKSSQNMFKQLHDAFSVGIKDFMVQFNTYLQHMPQPQAGSGNTEEINNKLSMLKQLVESSLHKHRTELTDAMLETQREVKSLEILLARQVQETIRAELRKHMEAQNVAMRSQAATPAPPYDLRDSIKQLLMAGQINKAFHQALLANDLGLVEFTLRHTDSNQAFAPEGCRLEQKVLLSLIQQISADMTNHNELKQRYLNEALLAINMADPITREHAPKVLTELYRNCQQFIKNSPKNSQFSNVRLLMKAIITYRDQLK", "function": "In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets.", "AFDB_id": "AF-Q9VKK1-F1-model_v4" }, { "swissprot_id": "Q9FLV9", "sequence": "MEEKPNYVIQVEEELPTLLRKATTEEMVGFDNYKENGHPFPHSISRFHPSHASTTTLNGQETSRSIDTMEAHHHNYNETTPWTHQRKPSISMPTSPNVLMISDPTTSLSSENHKNSGSTGKSVKFLSQPMTKVSSLYIESGNGDDDRRQSHDNHHHHLHRQHQSGHHQNQNQAANKLKDNRYNSFKTWSGKLERQFTRKPASVEPEAPNRNNQNLNTNEAMPVDRYYDALEGPELETLRPQEEIVLPNDKKWPFLLRYPISTFGMCLGVSSQAIMWKTLATAEPTKFLHVPLWINQGLWFISVALILTIATIYLLKIILFFEAVRREYYHPIRINFFFAPFISLLFLALGVPPSIITDLPHFLWYLLMFPFICLELKIYGQWMSGGQRRLSRVANPTNHLSVVGNFVGALLGASMGLREGPIFFYAVGMAHYLVLFVTLYQRLPTNETLPKDLHPVFFLFVAAPSVASMAWAKVTGSFDYGSKVCYFIAIFLYFSLAVRINFFRGIKFSLSWWAYTFPMTGAAIATIRYATVVKSTMTQIMCVVLCAIATLVVFALLVTTIIHAFVLRDLFPNDLAIAISNRPRPKQNSQHRWLDQLRNVSSENIENYLKFTDSDSSQSNDVEACNGKTQESDSS", "function": "Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. Binds to the highly selective inward-rectifying potassium channel KAT1 and inhibits its activity. Functions as an essential negative regulator of inward potassium channels in guard cells. Essential for the efficient stomatal closure and opening in guard cells.", "AFDB_id": "AF-Q9FLV9-F1-model_v4" }, { "swissprot_id": "P07247", "sequence": "MSISMLQDAQTRTLAAALAGIKQEDVHLDRSMSLSPPMSANTSATSAAAIYPAMGLQQAAAASAFGMLSPTQLLAANRQAAAFMAQLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTHLHSPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKEFQTEISMSVNDMYHTSGGPISPPSSGSSPNSTHDGAGGNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGEKPFECERCHMKFRRRHHLMNHKCGIQSPPTPALSPAMSGDYPVAISAIAIEASTNRFAAMCATYGGSNESVDMEKATPEDDGPLDLSEDGASSVDGHCSNIARRKAQDIRRVFRLPPPQIPHVPSDMPEQTEPEDLSMHSPRSIGSHEQTDDIDLYDLDDAPASYMGHQQH", "function": "Krueppel is a gap class segmentation protein. It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules.", "AFDB_id": "AF-P07247-F1-model_v4" }, { "swissprot_id": "A4D9R3", "sequence": "MIRVEDASIGTVWVTCLLAVGLYFIRSRLLSDQFAGFPSVNSRKPWEVLNVFAHRRFQQNGPEYLKAGFAKSPVFGVVTDLGPKLVVSGAFIEDFKDEKLLDHYRAMVEDFMAEVPGFESMFLGNLHNTVLRDVISVITRELDQFTLPLSDEVSTALGDTWSDSPDWTEVTLLPSMLGLIARVSSLIFVGEPLCRDPAWLETVVNFTIVRHQAILALHMCPAVLRPVLHWFLPPCQKLRREIKTARSLINSALEELRKNPPTDRFSSLAWVDAFASGKKYDATMVQLRLANASIHSSADLLAKVLINLCEQPGLIQDLRDEVISVLEENGWRASTLNQLKLLDSVLKESQRLHPITTGTFSRFTRQNIKLTNGTEIPTGTPVMVTNDVAGDAAIYPDPEVFDGYRYLRMREGADKARAPFTTTGQNHLGFGYGKYACPGRFFAATEIKIALCHMLLKYEWRLVKDSPHDMLTSGFASFRDPRARIEVRRRAPDPQEVVLTIK", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor. The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1. Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO. The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E. The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps. Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8. Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9. Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8.", "AFDB_id": "AF-A4D9R3-F1-model_v4" }, { "swissprot_id": "Q94AH8", "sequence": "MVSRSYSNLLELASGDSPTFGRMNRQIPRIMAVAGIMSNIDNDSKDTDLSPKDRIIIVANELPIRAQRRVDGNGSGSSSSSTCCSKGWNFSWDENSLLLQLKDGLGDEAIEVIYVGCLKEEIPLNEQEEVYQILLESFKCVPTFLPLDLYTRYYHGFCKQQLWPLFHYMLPLSPDLGGRFDRTLWQAYVSVNKIFADRIMEVINPEDDFVWIHDYHLMVLPTFLRKRFNRVKLGFFLHSPFPSSEIYKTLPIREELLRALLNSDLIGFHTFDYARHFLSCCSRMLGLTYESKRGYIGLEYYGRTVSIKILPVGIHMGQLQSVLSLPETERKVGELIERYGRKGRTMLLGVDDMDIFKGITLKLLAMEQLLMQHPEWQGKVVLVQIANPARGKGKDVKEMQAETYSTVKRINETFGRPGYDPIVLIDAPLKFYERVAYYVVAECCLVTAVRDGMNLIPYEYIVSRQGNEKLDKILKLEANNRNKKSMLVVSEFIGCSPSLSGAIRVNPWNVDAVADAMDSALEVAEPEKQLRHEKHYKYVSTHDVGYWARSFLQDLERSCGEHGRRRCWGIGFGLSFRVVALDQSFRKLSMEHIVSAYKRTKTRAILLDYDDTLMPQGSIDKRPSSKSIDILNTLCRDKGNLVFIVSAKSRETLSDWFSPCEKLGIAAEHGYFLRLRKAVEWENCVAAVDCSWKQIAEPVMELYTETTDGSTIEDKETALVWSYEDADPDFGSCQAKELLDHLESVLANEPVTVKRGQNYVEVKPQGVSKGLIARRMLSMMQERGTLPEFVLCIGDDRSDEDMFEVICSSTEGPSIAPRAEIFACTVGQKPSKAKYYLDDTTEIVRLMHGLASVTDQITPV", "function": "Regulates plant architecture, shape of epidermal pavement cells and branching of trichomes.", "AFDB_id": "AF-Q94AH8-F1-model_v4" }, { "swissprot_id": "Q9VQS5", "sequence": "MQQDDEQEKSQQLQNFQSDDLLEKLKLLNYEKHLLKEFKLKPLSRFYFVKATNPGEQFYMFTLICWWLCKKLGKDMERPQEYDDPNTVAANIIKLLGEIDVPVDFQPNKLIRGAGPICLSVLEVLSTQACKVAQVGYQKLHIAQEEEFLGDYLEDNAEIILEKLEDEQNAAALSDDSDMELEAHNFRQLNWLNRPQKKSNGDVNLDERNPELDARMSDHQEWHLELERVLPQLKVFVKADARDWRTHISQMETLKTNILENSDTAEAQLKKLHSEFTFDLEKIESREKHLNNELKPLIQQFKELSIELSTIQYAQNQLQEDMEKQTAELNEVMMEQELKKEEMERRGQAMSDGSSVQQIRKAIAKLKDDTAQLNLEVALLVHAHDQDIVVRQLQQNQTTDLANNP", "function": "Required for the formation of cilia.", "AFDB_id": "AF-Q9VQS5-F1-model_v4" }, { "swissprot_id": "Q8KGG4", "sequence": "MYPGMLSEKRTNALPRGEIARGKSAVSRLFSQGGRLKGGFLLLIYSASRPVEQAPRIPVRVLFTVGKKLVPRAVDRNRIKRLMREAYRLEKNILTRALAFDAGKGDHQVMLAFLYRARADAIPSLERFRAEIRHMLKNLLSNRLPQTREGDRIE", "function": "RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.", "AFDB_id": "AF-Q8KGG4-F1-model_v4" }, { "swissprot_id": "Q9LE33", "sequence": "MAESSEPPVVLLHRPPSLTFMDEILTREFRTLITDTSSSESLPSFFPRHASSARAFVISGRLPVTDELLSHLPSLQILVCTSVGIDHIDLAACKRRGIVITNAGNAFSDDVADCAVGLLISVLRRIPAADRYVRSGNWAKFGDFQLGSKVSGKRVGIVGLGSIGSFVAKRLESFGCVISYNSRSQKQSSPYRYYSDILSLAENNDVLVLCCSLTDETHHIVNREVMELLGKDGVVINVGRGKLIDEKEMVKCLVDGVIGGAGLDVFENEPAVPQELFGLDNVVLSPHFAVATPGSLDNVAQIALANLKAFFSNRPLLSPVQLD", "function": "Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate (HP) into glycolate and glycerate. Mostly active in the presence of NADPH and glyoxylate.", "AFDB_id": "AF-Q9LE33-F1-model_v4" }, { "swissprot_id": "A2E5K9", "sequence": "MDIDPKDITISKEFQSIVVPKQLTGPVKAILQEKKLSATETKNVVDDPNGKRIILIPEVTELPKEVLEKVPEAKLEPYPVTLTYKQLTYIELLRHYIPEPLVIPTSFETIGHIAHLNLPDELLPYKKVIGECIILKNPCIKTVAIKQGPINNVYRNMELEVIAGKNDFITEVKQSGFTFKMDFSKVYWNSRLQYEHDSVVATFKENSLVCDAMCGIGPFAVRAAKKGCRVRANDLNPDSYYWLKENCKINGVSENVECFNMDAREFIRKQFDNGGCDYIVMNLPGTAVEFLDAIGEGAKKNRETARMPIVIFHSFDNKDGDYVASLRARAEKALGMKLPEMDIHNVRDVSPGKFMFRCTFSCADLFADEDDDKPHKVE", "function": "Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.", "AFDB_id": "AF-A2E5K9-F1-model_v4" }, { "swissprot_id": "Q4FQX4", "sequence": "MTINNQPEPTNEQRRIIYQARRGLKELDFYFEPYIKELYLTAEAAEQESFAQMLTHEDPDLLDYFTNQSRPEDDAMWALVNKIKTWRHSKSLS", "function": "An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.", "AFDB_id": "AF-Q4FQX4-F1-model_v4" }, { "swissprot_id": "D2TN58", "sequence": "MRIFVYGSLRTKQGNSHWMTNALLLGEYSIDNYQLYSLGHYPGAVPGNGTVHGEVYRIDNATLAELDALRTRGGEYARQLIQTPYGSAWMYVYQRPVEGLTLIESGNWLDRDQY", "function": "May play a role in antibiotic biosynthesis.", "AFDB_id": "AF-D2TN58-F1-model_v4" }, { "swissprot_id": "P46917", "sequence": "MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVDSSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNALQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIGGTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLVDRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKSVLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERVLHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEVWGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR", "function": "Involved in the biosynthesis of galactosamine-containing minor teichoic acid, a non-essential cell wall polymer in B.subtilis 168.", "AFDB_id": "AF-P46917-F1-model_v4" }, { "swissprot_id": "Q5H9N3", "sequence": "MEPHLKIDVSSASGSTTTGATASTSEAPQDSQAQQTMPPPSSDWSNQFNSPEAVSPKANGIKCFSPYSQEDMGPFVEQLLPFVRASAYNWFHLQAAKRRHFKEFDKKMCASEENAKLAELQNDRDELKVKWASRLLGKIKKDIQNDDKEAFISAINGSEPNKCIISVADQKGKMRRIDCLRQADKVWRLDLVTIILFKGIPLESTDGERLERSEACVHPLCINPFHMAISVRGLDVFMANYLKDVDTKITLTYPRNDELSDTVMVKQEPGEQTIVAPHAVLGTSSTHTRVWETNSERNAETIIITYDPQKACHTYFGGRATLAQQSLSAGNTYMVNKTAVDNNFFNAKRSVLCLPPPPIQNCFPYPIAGTSDSQQMDMSEDSNDGPSEKRSRDISSHDSPNSSTNDEVRRIVESGTEKLVLGSSIWAAPGQFSRTQQNQGAPGTSRQVRPLPDFQSQDSARSPGAFRSTAKPVCRMTVNTGNHGDVGVVVVDERNREHVIHAQHIVNALSSLRTTPSMRESPVGRKRMHPHTSNSFEFLNCNQEMNKNEGALGSDISPTHTAVSNLISRESSGYMASPTKFTTARGDTTSFSKIFQKIEEKHLQHNQPSTSYCNSQIQPPILSSKPVDSSVKLIAPVAVKPIMSGCNSIIPSPITTPRITPSFRMLEDDSLINVLGQLAHSNDGTTLNDSFIQHLIDTNSRSPLLSSGNAFSALSMGAVSGLVPGNSIHRPDSSASNGSNSLGVAMGLAVPQNIALAVQQTQNAMSPLHQIRVSVGAPPACSPSSSNSSLGAANQAPVSNTPQDPNAPKLPTDFSHALRNEKK", "function": "Probable transcription factor which recognizes and binds the palindromic sequence 5'-TTGGCANNNTGCCAA-3' present in promoters. Plays a role in locomotion, pharyngeal pumping, egg-laying, and life span.", "AFDB_id": "AF-Q5H9N3-F1-model_v4" }, { "swissprot_id": "Q4JTH1", "sequence": "MFYSCCVSIEPRDPASEPTPTPRRPLRKSQPRSFSQAQPLSWAQLESVLSGRGAGLRNLRAVGVGEGQRRTTSLDPAEAEGTGAEGASQKGITTPFAELHASSAYNFLRGASQPEQMVEAARELGLSALACVDRDGFYGAARFATAVAESGADLATVFGAELSLDVPLTVLCKGREGYTRLSRVIADARMADPDKDSVRYPSLPQLAEAAGGHWLVLLDWRRTDAQLVDFFGADNVVVELQHTMNPADADRNERLHALAVRHGLREIVSSAPTCATPKHSRLAGAKAALRERKDMAAAEPTTHPVGGSWLRSGEEMLQLAGDCEWLARAVETSVQVAEECAFTLDLVAPNLPHFPVPEGYTEMTWLRAITERGGAQRYGPRGSSAAANQAWATIDRELETIEQLGFPGYFLIVHDIVSFCHENNIFCQGRGSAANSAVCFALGITTVDAVASGLLFERFLSPERDGPPDIDLDIESGRREEAIQYVYSRYGRENAAQVANVITYRRRGATRDAGRALGYAPGQIDAWTRHPEQTPDVVQNLAEQMLDHPRHLGIHSGGMVICDRPIAQVVPTEWARMEGRSVVQWDKDDCAAVGLVKFDLLGLGMLEALHHAVDQVRAHRGREVELWRLDPTESEVYAMLSRADAVGVFQVESRAQMSTLPRLKPRTFYDLVVEVALIRPGPIQGGSVHPYIRRRNGLEPVTFDHPCLEPALTKTLGIPLFQEQLMQMAVDAAGFSGAEADTLRRAMGSKRSPQKMERLKKRFYQGLEAKNGIRGVVADRLWDKIVAFASYGFPESHSQSFASLVYYSAWFKYHYPAEFCVALLRAQPMGFYSPQSLLADARRHGVEVLPVDVNDSDVQVDAVASLATPPRTNRPTGVHGLGRGTGEPVGQIRLGLSGAGGVKGISAEVAERIVEARERIGRFTSVEDLSREAGLTVAHVEKLARAGALGSLGLTRRQAVWAAGVAATERPGMLPGTSGVHAPALPGMSAFEMVASELATTGVTTAEHPVQLLREYLDEWHLRPAPRGVHPGDAAPRGGAAVVTADSLLRVPDGTRVRVAGVVTHRQRPATAGGVVFFGLEDETGLANIVVSQGLWARQRAVALNAKILVVRGIVHNAEGAATVTADLLEQVETQLRPAGEIAGAHAGSRDFR", "function": "DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.", "AFDB_id": "AF-Q4JTH1-F1-model_v4" }, { "swissprot_id": "Q9Z429", "sequence": "MQQFTIRTRLLMLVGAMFIGFITIELMGFSALQRGVASLNTVYLDRVVPLRDLKTIADLYAVKIVDSSHKARSGRMTYAQAEQEVKDAGRQIDMLWHAYQKTKKIDEEQRSVDALAKLVDEAQDPIERLKGILERGDKAALDTFVENEMYPLIDPLSEGLSHLTQIQVEESKRAYDAAVVLYDSSRTMLALLLLGILICGGVFATRLIRSIIHPLTTLKDAAARVALGDLSQSIQVSGRNEVTDVQQSVQAMQANLRNTLQDIQGSAAQLAAAAEELQTATESTAQGIHRQNDEMQMAATAVTEMSAAVDEVADNANRTSNASHEAMDLADGGRKQVMLTRETIDRLSGKLNETTRTVFRLAEEASNIGRVLDVIRAIAEQTKLLALNAAIEAAHAGEAGRGFAVVADEVRNLAQRTQTSTQEIERMISAIQSVTQEGVRDVQQSCEFAARSQTMSSEADQALTLIAERITEINGMNLVIASAAEEQAQVAREVDRNLVAISDISEQSTAGVQQTSEASEELARLAANLNNLVNRFSM", "function": "Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for naphthalene or a related compound. May facilitate biodegradation.", "AFDB_id": "AF-Q9Z429-F1-model_v4" }, { "swissprot_id": "Q9ES82", "sequence": "MSANGSSVAQLLWQPPVCRSWKPDVEGAVYHLANCFLLMGFMAGSGVYGCFYLFGILGPGYLCCVLWGWFDACGLDIVLWNVLLTVACLLQLAQLVYRVRVNTLPEEFNLLYRTLCLPLQVPLQVYKEIVHCCHEQVLTLATEQTYAVEGETPINRLSLLLSGRVRVSQDGQFLHYIFPYQFMDSPEWESLHPSEEGTFQVTLTAETECSYISWPRKNLYLLLNRERYISRLFSALLGYDISEKLYTLNDKLFAKFGLRFDIRLPSLYHVLSPSASDGEPESEKDDEEALEAAVSPAQARPICIVPTPPCSAPPATTNFPVPLPRARMPRMPRPDSGNLASRRPLQNSSQVMSRSQAPLAPIHTPEL", "function": "Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.", "AFDB_id": "AF-Q9ES82-F1-model_v4" }, { "swissprot_id": "Q7DDQ4", "sequence": "MAMNKLNFLLLLAVCVSAFSVVMQQNQYRLNFTALDKAKKQEIALEQDYAQMRLQQARLANHEAIRAAAEKQNLHPPVSGNTFMVEHQR", "function": "Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.", "AFDB_id": "AF-Q7DDQ4-F1-model_v4" }, { "swissprot_id": "Q9VW43", "sequence": "MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRSDLVGLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKVQFVKRT", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9VW43-F1-model_v4" }, { "swissprot_id": "Q7FMW4", "sequence": "MADPQHVQEEAAGAEAVHAHAARHDGAVVMEILSRSLQSMPASPDVSAYFSGASSRRPSAADEVDDEEALRWAALERLPSFDRLRTGLMRADADSSGVGVGAVGRGRRWYAHREVDVRTLELAQRQAFVERVFHVAEEDNERFLKKLRARIDRAGIQMPTVEVRFRNVNVQAECHVGTRALPTLANVSRDVGESLLGLVGLNFAKRKALHILKDVSGIVRPSRMTLLLGPPSSGKTTLLLALAGKLDPTLETSGEVTYNGYGLDEFVPQKTAAYISQHDVHAGEMTVKETLDFSAKCQGVGQRYELLKELAKKERQLGIYPDPEVDLFMKATSVEGSTLQTDYILRILGLDMCADVIVGDELRRGISGGQKKRLTTAEMLVGPTKVLFMDEISTGLDSSTTFQIIRCIQQIVHMGEATVLVSLLQPAPEIFELFDDVMLLSEGQIVYQGPREHVLEFFERCGFRCPERKGVADFLQEVTSKKDQEQYWIQSEKPYRYVSVPEFVAKFKKFHMGKSLKKQLSVPFNKGKIHKSALVFSKQSVSTLELLKTSCSKEWLLMKRNSFVYIFKTVQGILVALIASTVFLRTQLNTRDEDDGQIYIGALIFVMITNMFSGFADLSLTLARLPVFYKHRDFLFYRPWTFALPNVLVRIPSSLFESIIWVAITYYTMGFAPEASRFFKHLLVVFMLQQMAAGLFRVTAGLCRTVVVTNTAGSLAVLIMFVLGGFILPKDAIPKWWVWAYWCSPLTYAYIAFSSNEMHSPRWMDKFVPDGKRLGVAVLENSGVFTNKEWYWIATGALLGFTILFNVLFSLSLMYLNPVGKPQSILPEETDSQENIQEGKNKAHIKQIITVETPEPVSPNSIITLDKVIQQLRGYSANTSDRSHSYINAAGRTAPGRGMVLPFEPLYMSFNEINYYVDMPLEMKSQGVTADKLQLLSGISGAFRPGVLTALMGVSGAGKTTLMDVLSGRKTGGYIEGEIYISGYPKNQATFARISGYCEQNDIHSPQITVRESLLFSAFLRLPKEVNDQEKKIFVDEVMELVELTGLKDAIVGLPGVNGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVNTGRTVVCTIHQPSIDIFEAFDELLLLKRGGQVIYSGPLGTNSHKVVEYFEAIPGVPKIEENRNPATWMLDVSSAASEVRLEIDFAEYYRSSTMHQRTKALVKELSNPPPGSDDLYFPSQYSQSTFNQFKLCLWKQWWTYWRSPDYNLVRIFFALFTALMLGTIFWRVGHKMESSKDLLVIIGSMYAAVLFVGFENSVTVQPVVAVERTVFYRERAAGMYSAIPYALAQVVVEIPYVFVETVIYTLIVYPMMSFQWTPAKFFWFFYVSFFTFLYFTYYGMMNVSVSPNLQVASILGAAFYTLFNLFSGFFIPRPKIPKWWVWYYWLCPVAWTVYGLIVSQYGDVEDFITVPGQSDQQVRPFIKDYFGYDPDFMGVVAAVLAGFTVFFAFTYAYSIRTLNFQQR", "function": "May be a general defense protein.", "AFDB_id": "AF-Q7FMW4-F1-model_v4" }, { "swissprot_id": "Q6AC77", "sequence": "MSDQNLGQGSDEPEREEPIVRDKRRIDPETGKVREPQDLSHEELVDVGPAGESQGEEILSDDDLDLLSGQTTADQLAADQLAADQLAAERLADLQRVTAEYANYRKRTESNREIERERAIGDAVKGLIPVLDDLERADTHGDLIEGSAFATIAAKLRASVERLGLLPYGEKGEPFDPQIHEAIFQQPTPGVTADTVADVVETGYRLGSTTVRVAKVVVAVPA", "function": "Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.", "AFDB_id": "AF-Q6AC77-F1-model_v4" }, { "swissprot_id": "A0A0A2JY30", "sequence": "MWVNTLRCPEGIEKVFPGPFACYNRLFDPGSQLDSYALIEETLHTYGPFDGAFGFSQGAALIVSYLLERRAAYPDESLPFRFLILCSPVVPLAGNAEYCHRILGCLSRDNESRIRSCQDTQISDLPERARIAMTMLTDILDASTTITQEPRRFYLDRELPDVPCALHPDLCLTRLPVATLHVRGTTDAKALWNCGFLIQSFFDSPKLRVFEHKSGHDIPRSGPEVRQMLCAMEWIIAQSELP", "function": "Serine hydrolase; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals. Communesins are biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks derived from L-tryptophan. The L-tryptophan decarboxylase cnsB converts L-tryptophan to tryptamine, whereas the tryptophan dimethylallyltransferase cnsF converts L-tryptophan to 4-dimethylallyl tryptophan which is further transformed to aurantioclavine by the aurantioclavine synthase cnsA, probably aided by the catalase cnsD. The cytochrome P450 monooxygenase cnsC catalyzes the heterodimeric coupling between the two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold. The O-methyltransferase cnsE then methylates the communesin scaffold to produce communesin K, the simplest characterized communesin that contains the heptacyclic core. The dioxygenase cnsJ converts communesin K into communesin I. Acylation to introduce the hexadienyl group at position N16 of communesin I by the acyltransferase cnsK leads to the production of communesin B. The hexadienyl group is produced by the highly reducing polyketide synthase cnsI, before being hydrolytically removed from cnsI by the serine hydrolase cnsH, converted into hexadienyl-CoA by the CoA ligase cnsG, and then transferred to communesin I by cnsK. Surprisingly, cnsK may also be a promiscuous acyltransferase that can tolerate a range of acyl groups, including acetyl-, propionyl-, and butyryl-CoA, which lead to communesins A, G and H respectively. The roles of the alpha-ketoglutarate-dependent dioxygenases cnsM and cnsP have still to be determined.", "AFDB_id": "AF-A0A0A2JY30-F1-model_v4" }, { "swissprot_id": "P73735", "sequence": "MTDARPRICILGGGFGGLYTALRLGQLSWEGHTPPEIVLVDQRDRFLFAPFLYELVTEEMQTWEIAPPFVELLAESGVIFRQAEVTAIDFDHQKVLLNDQDKGTESLAFDQLVIALGGQTPLPNLPGLKDYGLGFRTLEDAYKLKQKLKSLEQADAEKIRIAIVGGGYSGVELAAKLGDRLGERGRIRIIERGKEILAMSPEFNRQQAQASLSAKGIWVDTETTVTAITATDVTLQFREQEDVIPVDLVLWTVGTTVSPLIRNLALPHNDQGQLRTNAQLQVEGKTNIFALGDGAEGRDASGQLIPTTAQGAFQQTDYCAWNIWANLTGRPLLPCRYQPLGEMLALGTDGAVLSGLGIKLSGPAALLARRLVYLYRFPTWQHQLTVGLNWLTRPLGDWLKNEPS", "function": "Bifunctional oxidoreductase probably ables to act both on prenyl naphthoquinones and on prenyl benzoquinones. Catalyzes the penultimate step in the biosynthesis of vitamin K1.", "AFDB_id": "AF-P73735-F1-model_v4" }, { "swissprot_id": "Q97HJ4", "sequence": "MRELTSEIKKEIRDIVYDFFSEECEVDINELNDNTSVVDDLDGDSLMLIELVDILKKKYSLNIQLQSIGKYLLKNPAETLEKVVQTTYLLYEYENDITNVGEK", "function": "Acyl carrier protein.", "AFDB_id": "AF-Q97HJ4-F1-model_v4" }, { "swissprot_id": "A9MJC2", "sequence": "MGVMWGLISVAIASLAQLSLGFSMMRLPSIAHPLAFIAGLGAFTTATLALFAGLAGYLIPVSCWQKTLHSLALSKTYALLSLSYVLVRVVTRSVRRFLSKSDARRIVHCGGDNADFPARQLMMACASTAAIRRRNNIEH", "function": "Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.", "AFDB_id": "AF-A9MJC2-F1-model_v4" }, { "swissprot_id": "Q38C92", "sequence": "MRKAGANRNNERQGRNLGQQGPQMSPPGPSMMYPHHHQHQHHHQHQHQHQHQHQHPHQHPHQHHHHHPHHNGVYGNAYDNIRQPQMPPHSFGQGVSGSPWNSPPQQTPMYNQGYNQMSPGTGGGYGDMGGMYRDVHGGQYPSSPSHMGGGANIPYGRNPAMHNGLPAGAPLPGGYGALPHQGAHTPMGFGRGGQPLMEHMQPSGMYGAPMMRHDGYPDTRVSPPAQVGYGAGAPVGPPPPPPMPAGPPYGGVLPGAGVGPGGPMNASRPPAGIGGGGGGGGNAGYLEMRARGMGPQMPASNASRPPRIGTPDPGMMPPNRMNQSPMMGQGLPPQVGNFMPLPGVSPSPHAMIPTTPSMGDTFPGDDANMSGSTEALYDFLHDRGLVSVDNISKFFPEGYGKDDPALKVAVDGNFCLTSLRDELRKRDSLWFLHSTLPEELLMLVQQHVEWMRNMKLEPIWVFNGLSVSGDVETFLTTEAELRARDAVWSKLEDGEIPDEVEIQEAFDQPLGEDVQMAVARYLKEELGVMAVTAPFLNWAQMVAFHKEGIADLLMGPPEMLLLPYDEMKVIVQIDVSNSSVNYLDRDRVLRALFPNHVTETNTRVAGDRLMDLGLITATHAALSSARVTLNLSMQEVYEELSTPTPKFRSIKDFINAHACSQETGKKAGLSIKHSKGRGYLRYSAVFSTKSRDTPLVYLVRVLDPDLTNADMPTNLAGVLGHLVPLSLFYMQFSGLLSVRIMTAITQSYLRDECPVSDTKDYHTTLGLLMTMRSQVIGQILKRIAHPPPIKRTECLSWVRWFQPILAPMDRPRDLIDLDEWEISDSDQLKKLDEDCLADYSIASVLSVTADASRPAVEESNRPAGRVPIRYNSKRETFLAILLKSFDFLGYFSHSTAPNDAVDGMEMECCGMDGHDRGGSVPAAYHEKDLSSMKRSEASDINFMADEGLKDYPSVYFPIYLRATIKANPLDVQASFVLLTELVRVRIINSNPCRYINPANQQVEISMDDQDTNSDSRVLLASRIACLVKLPYRRASENLPFVWAPVYSRHLCAFTVMVRAMCRCLRELVEVITSTVFLSGNSSCSLQDFAEFASILPFGDVPSTIGGLLLHYVLVFPSDYQANLTSREERIEYLQGKFRDIPDLADHLHLVMSFTLQALYLINAYMLNDKETIVAKDQLTGTIVEDTIEMMWQKWRDHIDDNPPGDIHNLYPPRHQEPIPH", "function": "Involved in post-transcriptional regulation of gene expression.", "AFDB_id": "AF-Q38C92-F1-model_v4" }, { "swissprot_id": "P0AE25", "sequence": "MVTINTESALTPRSLRDTRRMNMFVSVAAAVAGLLFGLDIGVIAGALPFITDHFVLTSRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMAGAILFVLGSIGSAFATSVEMLIAARVVLGIAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTAFSYSGNWRAMLGVLALPAVLLIILVVFLPNSPRWLAEKGRHIEAEEVLRMLRDTSEKAREELNEIRESLKLKQGGWALFKINRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMALGTLVLGYCLMQFDNGTASSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDSIGAAGTFWLYTALNIAFVGITFWLIPETKNVTLEHIERKLMAGEKLRNIGV", "function": "Uptake of L-arabinose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).", "AFDB_id": "AF-P0AE25-F1-model_v4" }, { "swissprot_id": "Q47CW9", "sequence": "MNTLNDEAVVERIDKSLARSRVYSLLAIGLGFPDVESHAGFSDGRLMIEMHQALEVCMPGLAEYFSEQIAPRLKLTCSFEDFEALFLTAFETNMPVPSAALYEGVHVQQSNRPGLILELKGFYRNFGLTMDAQGNELEDTLTAELEFMHFLTAKQAQAEMESLSPNAYQRAQRDFLERHLVVWLPLVRAEVNAKVATQFFVALIDLAERFVDAHLEEMLFELNS", "function": "May function as a system-specific molybdenum chaperone protein essential for the assembly of the perchlorate reductase PcrAB complex prior to its periplasmic translocation via the Tat pathway.", "AFDB_id": "AF-Q47CW9-F1-model_v4" }, { "swissprot_id": "Q4L978", "sequence": "MSQKKIIIIGGGLGGISAAIRLAQSGFDVSLYDKNNHIGGKVNRLETEGFGFDLGPSILTMPYIFENLFNYSDKQMKDYVTIERLPLQWRSFFTNGEVIDLYEDLSQMLNANTYLTNDDIQQLHQFLNYAEKIHRFTEKGYFALGLDKVSEIIKYQGLLRSLKGVDYFSTMQQAINRYIEKQKLRDMLGYFIKYVGSSSYDAPAVLTLLIHMQYEQGLWYVKGGIHKLAQALEQLAIEEGVAIHTGMDVCSIDTYFNHITGVRLDDGSHVSADYIVSNREVIPTYRDLLHFSNKKIAQLEKVYEPAASGYVMHLGVDKEYAQLAHHNFLFSNDSKRNYREVFHDKVLPQDPTIYLVNSNKSDPTQAPEGHENLKVLPHIPYIQNQPFTEEQYSDFRERVLDKLEKMGLTDLRQHIIYEDIWTPHDIERTYGSNKGAIYGVVADKKKNKGFKFPKQSEYFDNLFFVGGSVNPGGGMPMVTLSGQQVADKINALECKVTTDSRE", "function": "Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of the terminal methyl side group of 4,4'-diaponeurosporene to form 4,4'-diaponeurosporen-4-al.", "AFDB_id": "AF-Q4L978-F1-model_v4" }, { "swissprot_id": "Q17381", "sequence": "MTSPSSDEDIIDIRVIKEEPESEPDSEAEPATTTNSTDSEDSVEQENKKLLETEKNRKREQKHKMLPNGTTSGTSDTGNQVPATSSAASSVDYTAMNAQDYLPTYSNTTLNYQPYQYQTAANGLLNYNNYSQYATANQLGSNYISPANFMQGGGISPLGFTTGTTGATTAAASVATSSASAVIGRSNGRSSSTVAASPADRSYSGVSGGQGQELTIQEFETVTEKIRRHGTYGQSKPPYSYISLITMAIQKSNSRQLTLSEIYNWIMDLFPYYQNNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSFWTLHEHCGNMFENGCYLRRQKRFKVKEREPSRKKRNANSQQLHQQQHIPKMEIKEEDPTSITTTSSLGAYSLIPQISTKKEIKEELKAVQDATAAAANLGLIDPSGTPSAVNHSQPTSVISSVGTLGTTQAQMTLNGQYASPYLYSSDFATILPQSQNFLNNTLYNTTSSYPGIDYTNGVYQNTLYSSTNPNSAANL", "function": "Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Becomes associated with pharyngeal target promoters by the 8E cell stage, playing a role in inducing large-scale chromatin decompaction, prior to the activation of transcription. Binding with target sequences in pharyngeal cells may be repressed by the nuclear lamina protein emr-1. Activates a wide array of pharyngeal genes including ceh-22, pax-1 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regulation of diet-restriction-mediated longevity by increasing expression of sod-1, sod-2, sod-4 and sod-5 but not sod-3. Positively regulates the expression of the transcription factor hlh-6 in the pharyngeal gland. May regulate gene expression in the intestine.", "AFDB_id": "AF-Q17381-F1-model_v4" }, { "swissprot_id": "Q5ZL54", "sequence": "MSAGGGGQRDAGTAGGRRSKWDQPGPAPAFLLSGAAPLPGRPFPGGGDGGTAVGVSESSAAPSGALDAAAAVAAKINAMLMAKGKLKPAPNTADKLQALGKGPATNKSKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTAEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRIKEIITNGVVKAATGSSPTFNGATVTVYHQPAPITQMSPAVGQKPPFQSGMHYVQDKLFVGLEHAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAAKKLCENLLQTVHAEYSRFVNQITTAVPLAGFAQPAAINSVPSQPSYYPSNGYQSGYPVVPPPQQPVQPPYGVPGIVPPAVPMAPGVLTTLPTGVPPVPTQYPISQVQPPASTGQSPLSAPFLPAAAPVKTTLPAGTQPQVQPHPQGQKRRFTEELPDERESGLLGYQHGPIHMTNLGTGFSSQSEIDGAGSKPASSSGKERERDRQLMPPPAFPVTGMKSESEERNGVGSLPGSHDHQAKKMKTSEKGFGLVAYAGDSSDEEEEHGGHKNASTFSQGWSLGYQYPSSQQRAKQQMPFWMAP", "function": "RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.", "AFDB_id": "AF-Q5ZL54-F1-model_v4" }, { "swissprot_id": "A0A1X9WEP1", "sequence": "MVFDRLAGIYDATGVEFFRPVARRLLDLVDPRPGVDLLDVGCGRGAVLFPAAERVGPGGTVVGIDIAEPMVRATAAEAAERGLGTVSVRLGDGADPAFPAGSFDVVTASMSAALFPDLPAVAARYARLLRPDGRIGLTGPVPPPSLREWALGPLRVGAVVDAIAPEAVAATHPRIAALLGAHPFGAPGAVADALRAAGFVEVRELHEDLELRAPSAEALVGWTWSNGLRVYWELVEPDRRAAVAAELVRDLTAHAAGGPITATYPVAYVTGRLRPAGGTP", "function": "Involved in the biosynthesis of nocamycin I and nocamycin II. Catalyzes the methylation of nocamycin E to yield nocamycin I.", "AFDB_id": "AF-A0A1X9WEP1-F1-model_v4" }, { "swissprot_id": "A9A2X4", "sequence": "MTFGAKTSGSDDLKAIISAISTLVEEATFVATAEGISFRGMDPSHVALIDISWPNSAFEKYECDSDIKFGVRIDEFSKLIKRADKKDSIEISISEQNMLLVTVGKNKKYKMRLIESSATDTPLPKIPYDSKIILSSSKFDKILGDVQVVSDYLTIHTSDSKGDFSGKGDSGEVVIDLDKDDEGIEEISSKEDSVGTYSLEYLNPVVKAVGTTAGFITCEFSSAKPLRIEFKVANIGRIHFYLAPRVES", "function": "Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.", "AFDB_id": "AF-A9A2X4-F1-model_v4" }, { "swissprot_id": "A0A0H2WWV6", "sequence": "MKKIFMMVHELDVNKGGMTSSMFNRSKEFYDADIPADIVTFDYKGNYDEIIKALKKQGKMDRRTKMYNVFEYFKQISNNKHFKSNKLLYKHISERLKNTIEIEESKGISRYFDITTGTYIAYIRKSKSEKVIDFFKDNKRIERFSFIDNKVHMKETFNVDNKVCYQVFYDEKGYPYISRNINANNGAVGKTYVLVNKKEFKNNLALCVYYLEKLIKDSKDSIMICDGPGSFPKMFNTNHKNAQKYGVIHVNHHENFDDTGAFKKSEKYIIENANKINGVIVLTEAQRLDILNQFDVENIFTISNFVKIHNAPKHFQTEKIVGHISRMVPTKRIDLLIEVAELVVKKDNAVKFHIYGEGSVKDKIAKMIEDKNLERNVFLKGYTTTPQKCLEDFKLVVSTSQYEGQGLSMIEAMISKRPVVAFDIKYGPSDFIEDNKNGYLIENHNINDMADKILQLVNNDVLAAEFGSKARENIIEKYSTESILEKWLNLFNS", "function": "Attaches N-acetyl-alpha-D-glucosamine residues to poly(RboP)-wall teichoic acids (WTAs).", "AFDB_id": "AF-A0A0H2WWV6-F1-model_v4" }, { "swissprot_id": "Q03CR5", "sequence": "MKIVVLAGGRSTERNVSISSGYRITNALRQKGQQATFIDLFLGYDLEGKTVEQVFDDANTSKDLNISDAILTDEDINKLRPDGSTQLFGPNVMAICKAADIVFLALHGGDGENGKVQAVFDINGVKYTGSGPLASGITMNKVFSKEVMLYHGIQTSGFKEFKRDQGPKQTVPFDFPVVVKPTSGGSSVGTHIIHNQEELESGLEDVFRFDNSAIVEEFTPGREFSLGVVNGHAYSAIEIKVRSGWYDFKHKFQAGYTDFITPPKDLDEDVHQAMKDVAVQTMDVLGLQNYGRIDFFANEKGVWVIEANNLPGMTPLSLLPQEAEADGVDYGDLVMDIVNGKLKLYADGMTEAGLLTK", "function": "Cell wall formation.", "AFDB_id": "AF-Q03CR5-F1-model_v4" }, { "swissprot_id": "Q9SWA6", "sequence": "MSKETKGNNNTSRVMSGYGGSLEANTLAMIDSTGAKDSRDANEDRLQYLEAVRAASLVPENGIPPTNKMYQAIFRILRFGKTLELITASFQLLTQLHQRFPWVYVSDSADQLDIVDEAWSPFNFGSDVDSDEKDLSVRSLFLQQLIQNMNKRVNESEESDLKILGNMFLFKYLAHVLKLDFTPRNQVYEETMNWSLLKESFLNLLLASRKVNFKLLMKDYLSTMCASIDADEKSISLVELHKDMLTAMKELLVMIMELDTSKKKADLEGITSRGDGVRTPAMEIILDELTYDGYLLSKFLQVFDDPKWKLEIVLQYLTKYIPKPVVRTRRTTVPQAEDSKTLNGILKTFSNGTNPKNITKKIGPDIVQILIGHAFLARLTFSDPHEGDSISEICSSIISAFTSLKRVDQKIEILPFGKEVLFTAGMVLKAKA", "function": "Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Transcription repressor that prevents expression of pathogenesis-related genes (PR) via histone modifications and binding negative cis-acting elements at their promoters. Negative regulator of hypersensitive response (HR) and systemic acquired resistance (SAR) required to dampen the basal expression of pathogenesis related (PR) genes. Functions synergistically with NTL9/CBNAC as negative regulator of pathogen-induced PR1 expression and basal resistance to a virulent strain of P.syringae. Binds to the PR1 gene promoter to suppress defense response in the absence of pathogen challenge and is removed in response to induction. Regulates negatively both gene expression and DNA recombination during pathogen infection, thus being involved in short-term defense response and a long-term survival strategy. Prevents effective immune responses that involve activation of DNA damage responses, probably by negatively regulating the DNA damage sensors RAD17 and ATR. Negative regulator of defenses against the beet cyst nematode H.schachtii.", "AFDB_id": "AF-Q9SWA6-F1-model_v4" }, { "swissprot_id": "Q6CZ26", "sequence": "MKKTSDYAVAVIGLGSMGFGAAASCINAGLTTYGVDINPQALEKLRQAGAAQADTRIDAFADKLDAVVLLVVNATQVNGILFGEPQVAAKLKPGTVVMVSSTISAQDAKNIEQRLAEHQLVMLDAPVSGGAAKAAAGDMTVMASGSDLAFEKLKPVLDAVAGKVYRIGEEIGLGATVKIIHQLLAGVHIAAGAEAMALAARADIPLDIMYDVVTNAAGNSWMFENRMRHVVDGDYTPKSAVDIFVKDLGLVTDTAKSLHFPLPLASTAFNMFTAASNAGFGKEDDSAVIKIFNGITLPEKKEAP", "function": "Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).", "AFDB_id": "AF-Q6CZ26-F1-model_v4" }, { "swissprot_id": "A9KNW3", "sequence": "MRKNSIKNTRINQEVQKELSMLISRELKDPRINPMTSIVAVEVAPDLKTAKVYISVLGDELSQKNTLAGLKSAAPFLRGQLARGINLRNTPELLFVVDQSIEYGVSMSKLINEVNAGNHKASDEEESDDKGHEDEQ", "function": "One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.", "AFDB_id": "AF-A9KNW3-F1-model_v4" }, { "swissprot_id": "A5WCA0", "sequence": "MTTPVCISQAFMDSFHAHHAQLLGKRVWLACSGGRDSLGLALLCRTLFDQGRLPFLPQLIHVNHGMQAANDEWAQQVAQWAQQHDMACQIIGLNLTHKSEQAARDGRYQAMMQLMNQDDVLILGHHQDDQVETLLMRLFNGAGVTGLGAMREWTSKQAHTAQSPPDVNKPRQRIFLWRPWLEISRDQITEYAQRHNLKYIDDPTNVAQSPSKLALQTLNDRAWLRSVLLPHITERYPQASEAMARTAQLMQQASDSIDEQVTQDLAQVALAATEQQSVIALDKLAGLSAPRQAALIHHWLAPYPNQLPPSKRLVDEVLALSFRQDSNHQTCLYFDAGSEQYQVRRYQNKLYRLQHAYAQWLQMMPHQIHLPLAHNAEELSLNLADTDVLSLKQSGLEFDWQLTGVRGLMAHLARLLNSADAKVTPCQLIFEPLPRTIKLALAGRSGRKSGKKLLQALDQPSFMRGSVVLCRLDMMGSDGILQDSSTAVPLFIICIDRIWVLQSQFTALINQLLATEVLSTQILEC", "function": "Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.", "AFDB_id": "AF-A5WCA0-F1-model_v4" }, { "swissprot_id": "Q47142", "sequence": "MVLQSTRWLALGYFTYFFSYGIFLPFWSVWLKGIGLTPETIGLLLGAGLVARFLGSLLIAPRVSDPSRLISALRVLALLTLLFAVAFWAGAHVAWLMLVMIGFNLFFSPLVPLTDALANTWQKQFPLDYGKVRLWGSVAFVIGSALTGKLVTMFDYRVILALLTLGVASMLLGFLIRPTIQPQGASRQQESTGWSAWLALVRQNWRFLACVCLLQGAHAAYYGFSAIYWQAAGYSASAVGYLWSLGVVAEVIIFALSNKLFRRCSARDMLLISAICGVVRWGIMGATTALPWLIVVQILHCGTFTVCHLAAMRYIAARQGSEVIRLQAVYSAVAMGGSIAIMTVFAGFLYQYLGHGVFWVMALVALPAMFLRPKVVPSC", "function": "Probable permease involved in the uptake of 3-phenylpropionic acid.", "AFDB_id": "AF-Q47142-F1-model_v4" }, { "swissprot_id": "Q6L1M2", "sequence": "MMTSKINYYIDLKRFDYKKCLDIQYRLVSMRKNDLIGNTIIFVEHDPVYTIGRKADPRNYSNVNVIRTDRGGDITYHGPGQLVSYFIFDVRINGKKEVKTFLNNIENVYINLLKNLGYSASTGDEPGIWIEKNGKLKKVASIGMAIDDYVSYHGVALNINKEVLNGFIKINPCGLPPAVMDYIDIKRDDAIDLIIREIEKIYGKFNKIEYEGLIS", "function": "Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.", "AFDB_id": "AF-Q6L1M2-F1-model_v4" }, { "swissprot_id": "B9L1E4", "sequence": "MKITVEHLPQSTVRLDIAADPEEFDAALERAFRRISQQVQVPGFRPGRAPRALVERRVGRELIVAEAQRELMDRLYREALQQHRLTPVAEPEVEIYQDEPLAFRVEVQVYPQVDLDGYRDIRVEPREVEVTEEEIDQVIEGLRRSRAVWKTPDEPRQPRDGDQVIVDIEAYEGEQPFQEPLRQATFVLGESNLFAEIDQAIRSLRPGESAEFDISFAEEDERVSPELRGKTLHYRVTVHEVKEAELPEVNDEFAQSLGVATLSELRDRVRRDLLREKAQAARAEVLEQAVQRLLEVATVELPPALIERQVAADVERLREQLRQRGSSLEEYLRFQGKTLEEFKEELRPQAEARLRRYLVLEAFAEAEGIAVSEEELVAEIERLALASGSPEQFRAFYSVPSVRSYLADELHERKVSERLLELVTEGRGAVIGEAARVLAGAEPAEGTEPAAEEAVTAPEVVDGETTPASESAESLAVTETGSRADDDQAS", "function": "Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.", "AFDB_id": "AF-B9L1E4-F1-model_v4" }, { "swissprot_id": "Q9HDY9", "sequence": "MSIALAFFILVLLGFSWASPSALDDTFNVSRSVGLISSSNLESCQSSPLEVGNIYNSTSASEILSTLDAKYITIIGVIGSSNSSIQDLIDSVGNSNNAASSNPTSTVTEYVDRVQTVTEYVTLSCGQAFTSTVDISSSTSSSVINSPTGTAVSSQISTLSMSPSSTPVFSPSASVSSKVASSVSYVSSEPSDSSSSTNTVILTTSVNSPAVSSSETLTSVSITSTESAYTSSSVDIAASTTASSTLPVSTSEATVSFSTDIPATPSTLSSPASSSSSYLVETSSTLTDSVFTTVTATSDSSVITYTLINSVTSSSETTNLPSSSSSLVTIGESSFPSSLLSLLTQSFSTVRSTSSSSTDQLTSASPISSSVISPSVSSPTSSILTNSGSIKSGDHQIVTTSFVQTTTHGSQVETLTYVTTLTETILTTTYDSHTFLTTITPSPSNSISYTNNTFIPSSSIKSSIVYSVTPTSAENYTSSEAFSTSSSLVVIPPVNSSLVTSSTSFTKFSSLSSSQLSTENFTSASSSLSLTNAKSSLSTPSTTIPTSNSSVSLQTSSSLIISSPIISSSLTATSTSTPALTHSITPSNTSYTSSLIPSSSTDYSSSLITVCSNVTSEISSTSLASLISTLTSQQISSNKSSEFVGQTTTEYTTSGSVGFTTTLATQSGSVPGTVLVDVPTPSWITETVTSGSVGFTTTIATPIGTTAGTVLVDIPTPSWVTETVTSGSIGFTTTIATPIGSTAGTVLVDVPTPSWVTETVTSGSVGFTTTIATPIGSTAGTVLVDIPTPSWVTETVTSGSVGFTTTIATPVGTTAGTVLVDIPTPSWVTETVTSGSVGFTTTIATPVGTTAGTVVVDVPTPSWVTETVTSGSVGFTTTIATPIGSTAGTVLVDIPTPSWVTETVTSGSVGFTTTIATPVGTTAGTVLVDIPTPSWVTETVTSGSVGFTTTIATPIGTTAGTVLVDIPTPSWVTETVTSGSVGFTTTIATPVGTTAGTVLVDIPTPSWVTETVTSGSVGFTTTIATPIGTTAGTVLVDIPQQHATTTTTTTFDGFSGYTSSYTGSITETIVIGTPHHSVVDVS", "function": "M cell-type specific protein involved in agglutination during conjugation.", "AFDB_id": "AF-Q9HDY9-F1-model_v4" }, { "swissprot_id": "F4KF14", "sequence": "MTFYISSSLTPTHFSKPLNPSNTLFPSQFRGSLSSFVRRRKPTEAKLSSKFNLFPSRRNGLITCCSTSSFESTESSVSQEEDAESNRLFEKLRETERERLSNMEELERKANVQLERQLVMASDWSRTLLTMRGKLKGTEWDPETSHRINFSDFMKLLDSNSVQYMEYSNYGQTISVILPYYKDGEPLGEEEDSKKEIIFRRHIVDRMPIDGWNDVWKKLHQQIVNVEVFNVDVVPAEVYTTVATFVVWSMRLALFVSLYVWIDSITRPIYAKLIPCDLGTPTKKIRQPLKRQALGSLGKSRAKFISAEEKTGVTFDDFAGQEYIKRELQEIVRILKNDEEFQNKGIYCPKGVLLHGPPGTGKTLLAKAIAGEAGLPFFAANGTDFVEMFVGVAASRVKDLFASSRSYAPSIIFIDEIDAIGSKRGGPDIGGGGAEREQGLLQILTEMDGFKVTTSQVLVIGATNRLDILDPALLRKGRFDKIIRVGLPSKDGRLAILKVHARNKFFRSEDEKEELLQEVAENTEDFTGAELQNVLNEAGILTARKDLDYIGREELLEALKRQKGTFETGQEDSTEVPEELKLRLAYREAAVAVLACYLPDQYRPISETDINSIRSQPNMRYSETSGRVFARKSDYVNSIIRACAPRVVEEEMFGIENLCWISAKSTLEASQRAEFLILQTGMTAFGKAYYRNQRDLVPNLVPKLEALRDEYMRFAVEKCSSILQEYQSALEEITDVLLEKGEIKADEIWNIYNTAPRIPQKPVRPVDEYGALIYAGRWGIHGVSLPGRVTFSPGNIGFATFGAPRPMETQIISDDTWKLVDEIWDKKVEEIKAEAVIQIEEEKKKPQILMATHFF", "function": "Functions in chloroplast biogenesis and chloroplast division. Required for plastid development during embryogenesis. Might be involved in chaperone functions or play a structural role in the thylakoid FtsH complex.", "AFDB_id": "AF-F4KF14-F1-model_v4" }, { "swissprot_id": "P40532", "sequence": "MDATQPQYELSVVTQCLKSAIDVIQWLIPTITKFSQSHPLVFQLLFIFFTFYVFYKLLMNFITLVKRFLYLTLVVTCIGIYMRGSQQFLTVDLLNFYNFVMSNRYYAFKIYTLFINALEREINTVYHLAQMKMEQLLK", "function": "Involved in the regulation of lipid homeostasis in the endoplasmic reticulum, thereby impacting nuclear pore complex biogenesis and localization, and nucleocytoplasmic mRNA transport.", "AFDB_id": "AF-P40532-F1-model_v4" }, { "swissprot_id": "Q54R14", "sequence": "MENNNNNNKNDNEINFKKIEINETLESGKFIESKIDMKLGELIIKVQSPMCFSFHKHLVNQFCFNCFSNSHEINNAKFNKFKVDINKNYIIRCNNCKLIYFCSDECFEKVMSIESFQDSTSTNIHTPLECLILSNYHDQTISPKINTLHDQTENRMIINYLSKIAYSTNNNNKFKLLLIEMNQLIGDFNNDNNNQTLSLNEIKNIKNKSFNLRKLFNNFFFNIDKVIIEELYAKSQRNSFGLWKNSDECFGLSMYGNQTIYNNNNDKDDNISISYFNHSCFPNCVRVQENQSISIYSLIPIKKGDELSISYIDIRMSKNDRLLHLKEIYYFECKCKRCTLPPLSNLSLEIEKTIENYTCKNQSIKCTGILYLPPFNKIQRICNFCHWKEPINN", "function": "Probable methyltransferase.", "AFDB_id": "AF-Q54R14-F1-model_v4" }, { "swissprot_id": "O75888", "sequence": "MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL", "function": "Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.", "AFDB_id": "AF-O75888-F1-model_v4" }, { "swissprot_id": "O61967", "sequence": "MPAFFCLPMACQRQVDSIDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVLPAEIGNLTQLIELNLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITILSLNETSLTLLPSNIGSLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEIGKLTSLREFYVDINSLTSLPDSISGCRMLDQLDVSENQIIRLPENLGRMPNLTDLNISINEIIELPSSFGELKRLQMLKADRNSLHNLTSEIGKCQSLTELYLGQNFLTDLPDTIGDLRQLTTLNVDCNNLSDIPDTIGNCKSLTVLSLRQNILTELPMTIGKCENLTVLDVASNKLPHLPFTVKVLYKLQALWLSENQTQSILKLSETRDDRKGIKVVTCYLLPQVDAIDGEGRSGSAQHNTDRGAFLGGPKVHFHDQADTTFEENKEAEIHLGNFERHNTPHPKTPKHKKGSIDGHMLPHEIDQPRQLSLVSNHRTSTSSFGESSNSINRDLADIRAQNGVREATLSPEREERMATSLSSLSNLAAGTQNMHTIRIQKDDTGKLGLSFAGGTSNDPAPNSNGDSGLFVTKVTPGSAAYRCGLREGDKLIRANDVNMINASQDNAMEAIKKRETVELVVLRRSPSPVSRTSEPSLNGSSHQLNHFDAGSPDSTMFVTSSTPVYAS", "function": "Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical junctions.", "AFDB_id": "AF-O61967-F1-model_v4" }, { "swissprot_id": "Q2UPC3", "sequence": "MSFIPVEHIACSTAKLPSSRCPLLLLQPNGSSTKPVRWRSACNQCHAAKVRCSGERTGCDRCNNLQYQCVYAISRVGKVPGVRARGNKAVRTTTEALQRPATASTLPDADSTGEFQTDQRSENDPLSRSDFGEQDAAHDALSPKSHSALFPDWTEASDKSLNAYETADLFILPSQLMSSDQDPSRSRGHSLQAPSHSGHSIADSHTAAMPDGGLFCPFNKPTTPIPALPDLDLHIQDFHPMDVPVSPLDNGPPVKRRPYSDASCGHSGHSSKGYMSSTFPYSELLSQIGCQTDCGRQPHHYNYRSWTVLICNRIVEFLEHRIQGGVVALDVVMQTNKVTLGEISRILSKGAHKEGSNCAMLLLIAIDQIVTLFECGVKQGSPGDSDRASIGGRDLSALGDDLTGGNVLPNLRFGLFQINQDEQLALRSYLLQRELQRCLQVLTNLRDAIPLEPNPCTALEARVKKLCSAIADSH", "function": "Transcription factor that specifically regulates the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells.", "AFDB_id": "AF-Q2UPC3-F1-model_v4" }, { "swissprot_id": "A0A509AKI1", "sequence": "MVLLNGKLKYIAVVAIFYNLIILLVKEKFPYICTKKKFHAISNRILYEYLNNFVSKDIFRREDITLKNLNFVQTNLKSDKDAEIKENRDTQSVDDNMFQRVYKFILNFFYGNKKNRINKSMNYGKYDNFNKINDIFEFMRNNGLPINITSVCLIDTGLNIKDALINYFLNHDISTYNSYTYHSVNINYKKPDSFNFGINSENCDEDNYSECESTFLENHNGHGKYEDKSTIQGDSLKLIEKKYDKNVDLQRSGIDVEICKAFNNSKEKKNSLNIIPVIKCLEYCKTKNVKIIHMDYNINEQNEQLIQIMDDLKNSEIFVILPSEKLFNEKPYEDNSVIYPSSFFEKFENVFFIGSLDYSDMSSDDADIASNFQIQKNEYLKYRKNNVFLLDSINSSLKKRDDHDILYYEIKYSSAFFINIITIILNIYPNMSIKELRNILSYSIPSKETAQLKTENIFEGNFDINKFIHILLNRGINSSGFVRKYKDVTPNESTNKIFLLEDQKDADIEPQKDSSIDIYCDEGGSDEDIVSTSNGLDVYSEYSHSNNKSDQLLNDEKGLKYETYKDLYSVKENDIYVFESNNPTNSSFMQMNYDDKIKSKYLDNLEEANYQNHRTQFEINRNDNRYPIISEDNLRDRQNMHNIQMLNDGINYSENANNIEELYDNDFEDYRGKDLNPEYNKIRDNNNNKNINKEFGILNTWRKNNEGLYLSDSEEESQPFKWMDMHVDDIYQDRKKRLKGNNYDNRNGRVRRIYEDNKRGRYIKNRNMQKKKNFDRNLKNKRYLNRRTKRHINEKNKRIMREKKNKYNNSVLKRNEMKSHNNSQKTPKIIPRKYSR", "function": "Probable serine protease which plays a role in ookinete traversal of the mosquito host midgut epithelium.", "AFDB_id": "AF-A0A509AKI1-F1-model_v4" }, { "swissprot_id": "Q9NWK9", "sequence": "MEFAAENEGKSGGGLHSVAEGVRLSPEPGREGVRDLAGAEEFGGGEEGTGLTGIKEIGDGEEGSGQRPEEIPMDLTVVKQEIIDWPGTEGRLAGQWVEQEVEDRPEVKDENAGVLEVKQETDSSLVVKEAKVGEPEVKEEKVKEEVMDWSEVKEEKDNLEIKQEEKFVGQCIKEELMHGECVKEEKDFLKKEIVDDTKVKEEPPINHPVGCKRKLAMSRCETCGTEEAKYRCPRCMRYSCSLPCVKKHKAELTCNGVRDKTAYISIQQFTEMNLLSDYRFLEDVARTADHISRDAFLKRPISNKYMYFMKNRARRQGINLKLLPNGFTKRKENSTFFDKKKQQFCWHVKLQFPQSQAEYIEKRVPDDKTINEILKPYIDPEKSDPVIRQRLKAYIRSQTGVQILMKIEYMQQNLVRYYELDPYKSLLDNLRNKVIIEYPTLHVVLKGSNNDMKVLHQVKSESTKNVGNEN", "function": "Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.", "AFDB_id": "AF-Q9NWK9-F1-model_v4" }, { "swissprot_id": "Q9UUK3", "sequence": "MRCPLAYYYTQTTIPTQQKRKSKKMEELLSKQREECKELQSKITNLRKQLKEGNKKQKRALQQKISQMEADLSQKHATERQKLDKGDEETNETQQEDLLNTLLQQMEDTKITTAEKSSVQSSLNTKENTPQQPKKSRNRQKERLERRKAEMKKMSEQAELESEKMADLKNEEKKKFSKILEEAGLVAVDIPADGNCLFASISHQLNYHHNVKLNSQALRNKSADYVLKHCEQFEGFLLDEESGEVLPVSDYCNEIRNNSKWGSDIEIQALANSLEVPVHVYNTEGPVLKFNPSTVKFEKPLCIAYYQHLFGLGAHYNSLLYRDN", "function": "Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.", "AFDB_id": "AF-Q9UUK3-F1-model_v4" }, { "swissprot_id": "Q84V22", "sequence": "MKPRFPQNVYFLARYSYLRRFQHSQRRTFSSFLNNIRSNYSGARASPLGGSSGAGAGAGGGGTGDSKGNAFLVPGATMATILMLGALHARRLYEDKKIEEKREKGIELEFHPDIKASFLGVLPLRSISRAWGSFMSLEIPVWMRPYAYKAWARAFHSNLEEAALPLEEYTSLQDFFVRSLKEGCRPIDPDPCCLVSPVDGTVLRFGELKGNRGMIEQVKGHSYSVPALLGNNSLLPMEPEGKNESKEEAVGDKSDKSWLRVSLASPKLRENVSASPMKGLYYCVIYLKPGDYHRIHSPADWNATVRRHFAGRLFPVNERATRTIRNLYVENERVVLEGIWKEGFMALAAVGATNIGSIELFIEPELRTNKPKKKLFPTEPPEERVYDPEGLGLRLEKGKEVAVFNMGSTVVLIFQAPTANTPEGSSSSSDYRFCVKQGDRVRVGQALGRWKEE", "function": "Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Contributes only to a minor proportion of PtdEtn production.", "AFDB_id": "AF-Q84V22-F1-model_v4" }, { "swissprot_id": "B2S303", "sequence": "MSDRREQFQYAFLDSGIGGLPYAHALRVRVPEASLVYVADRVYFPYGNKSSAQIIARASAVLQKVQTNFSPHIVVLACNSMSVNALEFLRAQVSVPVVGVVPAIKQAVACSHKKHIGVLATQCTITHPYTACLRAQFGAGCVFQMRADARLIECLERGLIFEVEDMQREAVARSVMPFQEAGVDVLVLACTHFVHVRHLFQDCVGTSCTVVDSLEGVVRRTLRLCPPQSQLRGNAACYVTGARDAVCAARYARYAQHFGLRWAGFLDV", "function": "Provides the (R)-glutamate required for cell wall biosynthesis.", "AFDB_id": "AF-B2S303-F1-model_v4" }, { "swissprot_id": "Q6LX42", "sequence": "MDFVSLVNTVNSFVWGPYMLVLLLGTGIFLTLRLGFMQIHTLPYALKLAFSKHQDETSEGDISHFQALMTALAATIGTGNIAGVATAYVLGGPGAIFWMWVTAFFGMATKYAEAVLAIKYRTVDDNGEMAGGPMYFLEKGLPDHGLGKILGVAFAFFGAFAAFGIGNMVQTNSVADAVASNFGVDPLITGFVLAIFTAAVILGGIKSIGKATGIIVPFMAVFYILAGLVILAMNIGYIIPAFGTIFSSAFNFSAGFGALIGTAIMWGVKRGVFSNEAGLGSAPIAAAAAKTDHPGRQALVSMTGTFLDTIVVCTITGLVLTIAGLKAFPGLTDLTGASLTAASFDALMPMGGLIVTIGLVFFAYSTVLGWSYYGEKCFEYLIGTKGIRLYRIAFVLVAFWGATASLPLVWNIADTLNGAMAIPNLIGLLLLSGVVVSETKAFNEIRKNEAKNA", "function": "Catalyzes the sodium-dependent uptake of extracellular D-alanine and L-alanine. Can also transport glycine. Binds glycine and both enantiomers of alanine, while strictly excluding other amino acids.", "AFDB_id": "AF-Q6LX42-F1-model_v4" }, { "swissprot_id": "Q2SZI4", "sequence": "MREPRHVPQLRASGRRFPQRGRRHRFGKRNDAMSWSDRLVSRFNGARDAGGGAAPRTAARAASGARAAAGGLASVVNGARPTRSRMLDFDYSLLWVSIALLGLGVVMVYSASIAMPDSPKYASYHDYAFLLRHCVSLVVAFVAAVIAFRVPVSTWDKYAPHLFLIALVGLVIVLIPHIGKGVNGARRWIPLGITNMQPSEIMKLAVTIYAANYTVRKQEYMQSFAKGFLPMAFAVGLVGALLLLEPDMGAFMVVAAIAMGVLFLGGVNGKLFGGLVATAVGTFTMLVWLSPWRRERIFAYLDPWDERYAQGKAYQLTHSLIAFGRGEWFGVGLGGSVEKLNYLPEAHTDFILAVIGEELGFVGVLVVILLFYWIVRRSFEIGRQALALDRTFAGLMAKGVGIWFGAQAFINMGVNLGLLPTKGLTLPLVSYGGSGILLNCISLAVLLRVDYENRVLMRGGKV", "function": "Peptidoglycan polymerase that is essential for cell division.", "AFDB_id": "AF-Q2SZI4-F1-model_v4" }, { "swissprot_id": "Q09969", "sequence": "MSSFLEFAKPKMLDIKRKINFASGEKTDESVQPQQQTEQSSAQQTTPSAKAVSNPFITPLTESTPGMSESWVELAPSRTSLCSSVDINMVIIDEKDKDSRLSPVSIAQSPHVEFESLEQVKYKLVREMLPPGKNTDWIWDWSSRPENTPPKTVRMVQYGSNLTTPPNSPEPELYQYLPCESDSLFNVRVVFGFLVTNIFSFVVGAAVGFAVCRKLIKHHRQ", "function": "Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth. Required for the induction of mitophagy under stress conditions.", "AFDB_id": "AF-Q09969-F1-model_v4" }, { "swissprot_id": "P60065", "sequence": "MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVYAKMSSLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALVPIVGIAVFGWFWFKGETYMAAWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVLSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAGTPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIWAVIGSGAKEVMWSFVTLMVITALYALNYNRIHKNPYPLDAPVKQD", "function": "Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. Probably undergoes several conformational states in order to translocate the substrate across the membrane; keeps the substrate accessible to only 1 side of the membrane at a time by opening and closing 3 membrane-internal gates.", "AFDB_id": "AF-P60065-F1-model_v4" }, { "swissprot_id": "P47492", "sequence": "MVNKSNSLDELLKQIKITEIIQHYGVKIQTKGNSLLALCPFHDDKNPSMSISSSKNIFKCWACNAAGNGIAFIQKHDQLDWKTALKKAIEICGIKLENWNSNLLTKVDPKQKRYWEINNALITYYQTRLKRETNPNGMNYLVEKRKLNKTLIEQFQLGLAFHNEDKYLCESMERYPFINPKIKPSELYLFSKTNQQGLGFFDFNTKKATFQNQIMIPIHDFNGNPVGFSARSVDNINKLKYKNSADHEFFKKGELLFNFHRLNKNLNQLFIVEGYFDVFTLTNSKFEAVALMGLALNDVQIKAIKAHFKELQTLVLALDNDASGQNAVFSLIEKLNNNNFIVEIVQWEHNYKDWDELYLNKGSEQVILQANKRQNLIEYLVSFFKKQQLDQRVITNKIIAFLTKNQTILNDHSFLIFLIKNLVKLLEYSDEKTLYETVLKHKEKLVSKFDNNRFYINTSGHAQPPQELQKTTAALVQTAFEEAVNELWKPEIFAFALIDKRFLVELKQSHLDEVFKECNFNLFDVELFIEKARIYWSENQTANWVGFESVLDQNYLLNNKARLLEIKDIFLDELTCYQANDFQNYLKTFQTLLKQQKQRLKNLKLTL", "function": "RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.", "AFDB_id": "AF-P47492-F1-model_v4" }, { "swissprot_id": "P32611", "sequence": "MLVLGSLRSALSCSSTASLISKRNPCYPYGILCRTLSQSVKLWQENTSKDDSSLNITPRLLKIIPNDTDIVTLEKQDELIKRRRKLSKEVTQMKRLKPVSPGLRWYRSPIYPYLYKGRPVRALTVVRKKHGGRNNSGKITVRHQGGGHRNRTRLIDFNRWEGGAQTVQRIEYDPGRSSHIALLKHNTTGELSYIIACDGLRPGDVVESFRRGIPQTLLNEMGGKVDPAILSVKTTQRGNCLPISMIPIGTIIHNVGITPVGPGKFCRSAGTYARVLAKLPEKKKAIVRLQSGEHRYVSLEAVATIGVVSNIDHQNRSLGKAGRSRWLGIRPTVRGVAMNKCDHPHGGGRGKSKSNKLSMSPWGQLAKGYKTRRGKNQNRMKVKDRPRGKDARL", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.", "AFDB_id": "AF-P32611-F1-model_v4" }, { "swissprot_id": "Q5N800", "sequence": "MAAAAVVHLSVHGRLRRSPELHARPYHRPSLLRCRAFKQEADNGGEEASSSPPPPTTAEARRRRKGPLYKLKAAIQGLAGSRSAAAEAYGGEYQRAVEKAEEIFFSVATQVGRYVITMMSSGVVLGVGFQLSGGDSQMNTLIWYSWLGGVIIGTMIGANSVLEEHCKAGPRNVVITGSTRGLGKALAREFLLSGDRVVIASRSPESVLQTINELEENIQEGLSVAKKKQREILLHAKVVGTSCDVCKPEDVKKLVNFAKDELGSIDIWINNAGTNKGFRPLVNFSDEDISQIVSTNLVGSLLCTREAMNVMQHQQKGGHVFNMDGAGSGGSSTPLTAVYGSTKCGLRQFQASLLKESRRSKVGVHTASPGMVLTDLLLSGSSLRNKQMFNLICELPETVARTLVPRMRVVKGSGKAINYLTPPRILLALVTAWVRRGRWFDEEGRAVYAAEADRIRNWAESRARFSFTDAMEMYTENTWVSVFSLSVVCAFIILSSSGGPLPGT", "function": "Required for proper chloroplast degradation. Involved in chlorophyll b degradation.", "AFDB_id": "AF-Q5N800-F1-model_v4" }, { "swissprot_id": "P60231", "sequence": "MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALCGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIWSNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTSTEEPAKQQTTNTPALTT", "function": "Required for the transposition of the insertion element.", "AFDB_id": "AF-P60231-F1-model_v4" }, { "swissprot_id": "A0A0A1GNF2", "sequence": "MGSGKDRTLAGWTLPETKTDATAQFDRFVTENRFTIAVVFPLVGAVTLLASAEGLLPDPLAFNPYFVLFGTFVMRLPLVAGIFPLVDRRAGLALVALTLYSYGIELVGVRTGWPYGEFTYGVDLGPMLLGDVPFGLPVFFFPLVLNAYLLVLLLLGNRAASTTVRLLSTLATVMLVDLVLDPGAVAIGFWIYEMPQFYGVPWQNYAGWLLSGSVAVLLFDFGFDRAGLRRRLRDCPFMLDDLVSFVLLWGGINLFYTNWVPFGLAALLGAGLLWTDRFDFDLSETRLGRAVWR", "function": "Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR). Catalyzes the reaction that introduces hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin (BABR) to generate BR.", "AFDB_id": "AF-A0A0A1GNF2-F1-model_v4" }, { "swissprot_id": "Q889M3", "sequence": "MSDQPMNEVQDNAAPANPWLELRRLTPARIALGRTGTSLPTCAQLDFQAAHAQARDAVHLAFDHAAISAQLAEKGRETILLHSAAADRDSYLQRPDLGRRLNDESAQTLRDYAAAHPGGLDLAVVVADGLSALAVHRHAVPFLTRLEEQASAEGWTLSPVLMVEQGRVAVADEIGELLGAKMVVILIGERPGLSSPDSLGLYFTYAPKVGLNDAHRNCISNVRLEGLSYAMAAHRLLYLMREACKRQISGVSLKDEAQLNTLESDDSAENSDRKIGNFLLDGPAVPH", "function": "Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.", "AFDB_id": "AF-Q889M3-F1-model_v4" }, { "swissprot_id": "P57789", "sequence": "MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN", "function": "Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.", "AFDB_id": "AF-P57789-F1-model_v4" }, { "swissprot_id": "Q86DC6", "sequence": "MSKLNPRVAHNPVLSRIIESGRTNLPSGITSAGSLSAYAQAAAVTIRDNRDREKREIADLNNRLARYVEKVRFLEAQNRVLENDIGLFRQAAHIHTGKVRDYYDAEKTSLATLVREQEAKVSSAKQNIRKLEPEITTAIRTLASSLEHRQRVRSDKKEQLKHLSDLESETAYIKRLINDCDDEKSHLKTEISRIRGEIKRILALRDKERNGFSRSQTAAQDLLKKLNATISTHEIAIREEINKARRDSTDKNREFFHRELHMSMKEIRDQFESDSKKARKTWEEWYKKKITEIKKRSEKFSLTQNQAREEVLRIRSLLNELRTKISDADSMTQALSKRIEDMKFREDEELRMFEQSLTEKELAVTRMRDECAKLSVELETLVENQINLRSEIAHYRKLMEQAENLRTSYQSDFVIDTPSPLMRTSSHHYGSSYSLNVRDTHNKTVHHDNYDISSASTINTQQFRSYGKGDVKIIEHKDESIVIENSNSYKSKDLSNWKINHYVNGALTGTFILPVATHIHPHEKISIHSLKSPNLMDDIVATQIYSFDFSKNTKTVLLDDVDDEVGWYAHVSYSH", "function": "Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.", "AFDB_id": "AF-Q86DC6-F1-model_v4" }, { "swissprot_id": "O44406", "sequence": "MSADEPSPEDEKYLESLRDLLKISQEFDASNAKQNDEPEKTAVEVESAETRTDESEKSIDIPREQQLLPSERVEPLKSMVEPEYVKKVIRQMDTMTAEQLKQALMKIKVSTGGNKKTLRKRVAQYYRKENALLNRKMEPNADKTARFFDYLIAIDFECTCVEIIYDYPHEIIELPAVLIDVREMKIISEFRTYVRPVRNPKLSEFCMQFTKIAQETVDAAPYFREALQRLYTWMRKFNLGQKNSRFAFVTDGPHDMWKFMQFQCLLSNIRMPHMFRSFINIKKTFKEKFNGLIKGNGKSGIENMLERLDLSFVGNKHSGLDDATNIAAIAIQMMKLKIELRINQKCSYKENQRSAARKDEERELEDAANVDLTSVDISRRDFQLWMRRLPLKLSSVTRREFINEEYLDCDSCDDLTDDKNDEAAFQEKMAIREYLENKQTEDFAKIAAERGIFKIGEIKSYQTARPIIEDDDVDVESEEEDYGTEFEMLEVVERMPPVSSTLHTEVDLDAVWERDGGSDSERENLSNAPSLHEFPSSSTSSPHATSEHVTSSSPLHIDDDVDRVLNAPPKNSLASSSNRSSF", "function": "RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable).", "AFDB_id": "AF-O44406-F1-model_v4" }, { "swissprot_id": "P21857", "sequence": "HPITESAEMPYPGPASLEERGVGSLDDLSLSEQNYPPQRGAGLRYATLEVLLEKQSLLNPFSRVFGIRKQFAGTTECFWKYCV", "function": "Urotensin is found in the teleost caudal neurosecretory system. It has a suggested role in osmoregulation and as a corticotropin-releasing factor. The non-hormonal portion of this precursor may be a urotensin binding protein, urophysin.", "AFDB_id": "AF-P21857-F1-model_v4" }, { "swissprot_id": "Q8X1Z7", "sequence": "MALDDISAVPKGALDTDPAVERPPPLLDADRSDSERLQPGVKRAEMLRKGWTRQGLIIAFTGLFLATLSINFGDYSTQVYVPYATSAFKQHSAMSAARVVGNITRIAAYPIIAKLGDVFGRAEMFILSIVFQAVGYAIYAGCKNVGQYIAGGIFEAIGSTGFGLTQQVFVADVTNLINRAVWSTLPDSLTVIPALYLGTEIAEAVLEKNEWRWGFGMWAIIEPVCSVLLVGTMLYYQKRARKDPSPAEFASEPTERNVDDGWWKRIYNLVWVQLDAFGAILLLLGLSLFLVPLSLTGSGNSDDWHRGSFIAMLVLGVVIFVAFLAWDTWCAKKPFIPYRMIKNRTVAAACLLGILDFFHYSVFSVFFTSYLQVAAHHGAGPATRIDNSLRVAFQVAGIFAAYFMKFTKRSQVWVFTGVPLCVLGMGVLLYLVDMGEGRVGNEAAFVTAKSLIGIGRGFYQTASQVSVQAKVSRGEVSVVTAVFFAAMSIGGAIGTSVAGAIWRSTLPPKLAQHLPAELKDQAQAIFGSIVVAQKYEVGTPARDAIDMCYRQSQRMLAIAALAALAPMLIIMFFLENVPLTDETTLIELHGNREAVKKNHSGGEGKEARS", "function": "Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis.", "AFDB_id": "AF-Q8X1Z7-F1-model_v4" }, { "swissprot_id": "Q9LVW3", "sequence": "MGVFGSNESSSMSIVMYPWLAFGHMTPFLHLSNKLAEKGHKIVFLLPKKALNQLEPLNLYPNLITFHTISIPQVKGLPPGAETNSDVPFFLTHLLAVAMDQTRPEVETIFRTIKPDLVFYDSAHWIPEIAKPIGAKTVCFNIVSAASIALSLVPSAEREVIDGKEMSGEELAKTPLGYPSSKVVLRPHEAKSLSFVWRKHEAIGSFFDGKVTAMRNCDAIAIRTCRETEGKFCDYISRQYSKPVYLTGPVLPGSQPNQPSLDPQWAEWLAKFNHGSVVFCAFGSQPVVNKIDQFQELCLGLESTGFPFLVAIKPPSGVSTVEEALPEGFKERVQGRGVVFGGWIQQPLVLNHPSVGCFVSHCGFGSMWESLMSDCQIVLVPQHGEQILNARLMTEEMEVAVEVEREKKGWFSRQSLENAVKSVMEEGSEIGEKVRKNHDKWRCVLTDSGFSDGYIDKFEQNLIELVKS", "function": "Contributes to the last few anthocyanin biosynthetic steps. Converts cyanidin 3-O-glucoside to cyanidin 3-O-xylosyl(1->2)glucoside. Can use 3-O-glucosylated anthocyanidins/flavonols and uridine diphosphate (UDP)-xylose as substrates.", "AFDB_id": "AF-Q9LVW3-F1-model_v4" }, { "swissprot_id": "Q759B7", "sequence": "MFARAAAIASVPVMREGTALDAIDSRIIHCKGALARLKELERVVRLLTDSMAGNSAERTIIPLMSYVLALCQGPLFGVSPTLRKRYELLSQMRLVKLTEVNAAASLGAVDLWSRWPADEDDASAVRSKFYDETLHGRILEHLLHTTRNCHALYQRRHKLLLAERDACRTAETQEWNDLYSLAVDDFLVPSEITLGLELAVLITDRDTDTTDMAYQKLNIQVLGMLLEYFNGVAMPTINQYYLELQRAVRNKGINQNNILTSLPFWAHTLHRIFAMLLRAKYLLDIIQSVLRLAYLPNKTHFSHPTVQLASPNLYLFRNVLEKLDEICCGTTVLSARVTEYISPFLQQGVTHRLTYDKVVHLYKEAVRPTVSSLTEAIDLMSNLLKSWEASCSAEHISRLQTLSEDDVSTLSAVEDKFLIDKSLYEEGQKRKQENKKSPAANSTSKKQAVTLQRRPSNRIVSTNASPLRQQVIANGEKRISTAPPMRRRSLSLQRVSPSPDPDANRRSNSLQFSSTNQILLQSSVREALSRYQSRHANIERPLSTPPGTFPYHAFASSMVDEESRRIASLSLAEGNGPAAIKVMANMASEYEDTSRESSLSGCCNYQTYANQVLAQPQLAGSFPTVPLVKKVRFTGVPPPTEDEDPKPKRKGWYKKPAVLHYPTPSQSMIQKNKQRHEGYVFRTSLREQQREKHKQPGRRFAAFLDHVKDTNTLSGHKAGKIKSKLTR", "function": "GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.", "AFDB_id": "AF-Q759B7-F1-model_v4" }, { "swissprot_id": "P30197", "sequence": "MYGKLLICATASINVININHYIVELKQHFDEVNILFSPSSKNFINTDVLKLFCDNLYDEIKDPLLNHINIVENHEYILVLPASANTINKIANGICDNLLTTVCLTGYQKLFIFPNMNIRMWGNPFLQKNIDLLKNNDVKVYSPDMNKSFEISSGRYKNNITMPNIENVLNFVLNNEKRPLD", "function": "Catalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond.", "AFDB_id": "AF-P30197-F1-model_v4" }, { "swissprot_id": "O31073", "sequence": "MNHELPVISLFSGAGGLDCAIESCAEPPLVQDGSGSPLRVAVATDYEQTALDTLSANFPHTKTLCGDIQTIPTAELLEAGGLKPGDPTLVIGGPPCTPFSKSGFWIEEKRNSADPNASLLDEYVRVVRESKPEAFILENVQGLTYKTHQAQFDRLIAGLKDAGYNPTFRVLLAAEYGVPQLRRRVFVVGRRDGKAFHFPETTHSGESERDRVIDHTKIPFTSLREALAGLPDVPEAGEVVEGTYAELAAEVPPGQNYLWHTDRYGGRNEFKWRSRYWTFLLKADPDRPSTTLQAQPGPWVGPFHWENVKNANGEERARRFRVAEMKRIMTFPDEFVFTGVKREVQRQIGNPVPVELGKVVVRALMEQLGYLDSRGTTIPSQAGHEQLELI", "function": "A beta methylase recognizes the double-stranded sequence 5'-GAGCTC-3', methylates C-4 on both strands, and protects the DNA from cleavage by the SacI endonuclease.", "AFDB_id": "AF-O31073-F1-model_v4" }, { "swissprot_id": "X4Y2L4", "sequence": "MKEIAVTIDDKNVIASVSESFHGVAFDASLFSPKGLWSFVDITSPKLFKLLEGLSPGYFRVGGTFANWLFFDLDENNKWKDYWAFKDKTPETATITRRWLFRKQNNLKKETFDDLVKLTKGSKMRLLFDLNAEVRTGYEIGKKMTSTWDSSEAEKLFKYCVSKGYGDNIDWELGNEPDHTSAHNLTEKQVGEDFKALHKVLEKYPTLNKGSLVGPDVGWMGVSYVKGLADGAGDHVTAFTLHQYYFDGNTSDVSTYLDATYFKKLQQLFDKVKDVLKNSPHKDKPLWLGETSSGYNSGTKDVSDRYVSGFLTLDKLGLSAANNVKVVIRQTIYNGYYGLLDKNTLEPNPDYWLMHVHNSLVGNTVFKVDVSDPTNKARVYAQCTKTNSKHTQSRYYKGSLTIFALNVGDEDVTLKIDQYSGKKIYSYILTPEGGQLTSQKVLLNGKELKLVSDQLPELNADESKTSFTLSPKTFGFFVVSDANVEACKK", "function": "Hyaluronidase that mediates hydrolysis of (1->3)-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate. Very specific to hyaluronate: not able to hydrolyze chitin, heparin or chondroitin sulfate.", "AFDB_id": "AF-X4Y2L4-F1-model_v4" }, { "swissprot_id": "Q6D107", "sequence": "MIHTLLRWVFQRLYRIRIEGDSSQFQQSKLLITPNHVSFLDGVLLALFLPIKPVFAVYSSISDRWFMRWLKPYIDFVPLDPTKPLAIKGLIKVIERGQPVVVFPEGRISVTGSLMKVYSGAAFVAAKSGATIIPVRIDGIELSPFGRLAGVFKRRCLPQVTITYLPPTTLPMPEASSARARRALAGERLHQIMMKARMETRPQHTLYQAFLAARSRYGRHSASIADISFNEDSYQGLLKKSLGVSRILQRFTRADEHVGMLLPNATITAASILGASLRNRIPAMLNYTAGAKGLQSAMKAAGIKTIVTSRQFLEKGKLTDLPKQVSEANWVYLEDLKDTVTLKDKLWILFHLLFPARAMLPQKPDDAAIVLFTSGSEGNPKGVVHSHDSLLANVEQIRTVADFTPGDRFMSALPLFHAFGLTVGLLTPLITGARVFLYPSPLHYRIVPELVYDQNCTVLFGTSTFLGNYARFAHPYDFARLRYVVAGAEKLSETTRQVWQDKFGIRILEGYGVTECAPVVAINVPMATKIHSVGLLLPEMESRLITVPGITRGGRLQLRGPNIMKGYLRVENPGVLETPAAENAEGELQQGWYDTGDIVELDERGFCTIIGRVKRFAKLAGEMVSLESVEQLAVKVSPEAQHAASAKSDSSKGEALVLFTTDSQITRDVLLAQARSSGVPELAVPRDIRYVKALPLLGSGKPDFVTLRQMAEEPNSEQSVIEPSIVKQPITNASEPSA", "function": "Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.", "AFDB_id": "AF-Q6D107-F1-model_v4" }, { "swissprot_id": "Q9FMM4", "sequence": "MQGERASLGYLSEALNFEHGSSSSNGVIDHWENIHSLGDNDLQDYMIANSESNTSLANSVYHEQQGLRRFSLGEASSSGTKDEASSHNEQRMETRCFDGRGNEIIDLDPVFAQPSGTNQPVQNVNLNAEYIEIHEDINPYRGRSGFIEANGPGTRVSQPGRSFEENGVGTGSSVEGRRASCKRKALEGSISQSSSGGYHDFQRGESSSWTPGSTVFRPGNGLNISGSLDNGPRGMVSGTVPNFPVSAPNFPVSAIAESSSRNICVRSNPSDHQETVNPSTFAAGTVVRRPVPPSQLNLSRHLPADQHSLDLRPGQSFVVSRNPNSTPVSIPPGSRTMLPPFRWTGSSLVGGTSNSTAPVERNLHLDETRSRSIPGNTLEIPMFAAPEVGNFARSQSSRNVTNGNLNSASSVSRTGSTTSVPPPPPPSSNLAWTSYQNSPHYQRRRTERSELARRSLLSSLAADATNQRSGDHPTLRSLAPPASSDGLVLQPGGDNSQMHNRAYSRAGPLFDRQGDSVVGIPHPLRALAAASRGRSRLMVSQMQNVLDVMRRDANNNNLRLEDVMLLNHSVLFDGATGHDRYRDMRLDVDNMSYEELLALEERIGDVCTGVNEETISNRLKQRKYKSNTKSPQDAEPCCVCQEEYTEGEDMGTLECGHEFHSQCIKEWLKQKNLCPICKTTGLNTAKKRRIA", "function": "Probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro.", "AFDB_id": "AF-Q9FMM4-F1-model_v4" }, { "swissprot_id": "C4Z9Q0", "sequence": "MILEVLMSQSVTIKSNKYGINLILDADMPFADLIKAVVEKFKASANFFKNAKLAISFEGRHLSDEEQQQIIAAIEENTTIEILCIVESGTEQEAIMKEQVEAFNEAVQKQCENVATVSVPEQFYRGTLRSGQVITSESSVTIIGDVNPGAKIIAQGNIVILGALKGNVHAGCTGDRSCFVFALDMQPIQIQIGDLIAKSPDEPQPKHRVRRKEKPAQEQAQIAIAKDGYIYIEPITKNILNSI", "function": "Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.", "AFDB_id": "AF-C4Z9Q0-F1-model_v4" }, { "swissprot_id": "P57719", "sequence": "MNKLLRKVRKAFSLKADNKAETGIGTLIVFIAMVLVAAVAATVLVHTAGTLQQKATSTGSQTTQQVSTGIQVNSIYGLDSNKSVPTHGVIEWLAIQISITAGSSPINLANVTISLTYHGVSASLTYVGLENIGNATVTNDVYGFNSAVGGTNNVFNSSYFKTINGASNGSKHFAILVLSDPTNSMTAQYPVISYEDQVDLLVNVSAVFGGITEGQAVSGEVQAPVGSPGVIQFTAPESFVSDVIQLQ", "function": "Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.", "AFDB_id": "AF-P57719-F1-model_v4" }, { "swissprot_id": "Q9S9N6", "sequence": "MASSLPLLPKPISPFFKTPPFSTSKPLVFLNFQTRLTSRSSDVSVNLKKKNNPWLDPFDSGEDPDNEYGSLFADGKQDEDPRPPDNPDNPYGFLKFPKGYTVELASLPLKIRGDVRRCCCVISGGVYENLLFFPTIQLIKDRYPGVQVDILTTERGKQTYELNKNVRWANVYDPDDHWPEPAEYTDMIGLLKGRYYDMVLSTKLAGLGHAAFLFMTTARDRVSYIYPNVNSAGAGLMLSETFTAENTNLSELGYSMYTQMEDWLGRPFRSVPRTPLLPLRVSISRKVKEVVAAKYRNAGAVTGKFIVIHGIESDSKASMQSKGDADSLLSLEKWAKIIKGVRGFKPVFVIPHEKERENVEDFVGDDTSIVFITTPGQLAALINDSAGVIATNTAAIQLANARDKPCIGLFSSEEKGKLFVPYAEEKSNCVIIASKTGKLADIDIGTVKNAMQVFEGSLALV", "function": "NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-Q9S9N6-F1-model_v4" }, { "swissprot_id": "P36095", "sequence": "MDYIKKAIWGPDPKEQQRRIRSVLRKNGRNIEKSLRELTVLQNKTQQLIKKSAKKNDVRTVRLYAKELYQINKQYDRMYTSRAQLDSVRMKIDEAIRMNTLSNQMADSAGLMREVNSLVRLPQLRNTMIELEKELMKSGIISEMVDDTMESVGDVGEEMDEAVDEEVNKIVEQYTNEKFKNVDQVPTVELAANEEEQEIPDEKVDEEADRMVNEMRERLRALQN", "function": "Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment oflate-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III.", "AFDB_id": "AF-P36095-F1-model_v4" }, { "swissprot_id": "A0A1S3XQD6", "sequence": "MGSDKKTTEEKRKHKRNSPSSPRDEVKSKRQNIKGDEERRKEKDKSKKEKHKSHKSKCHSSEEKKSGEKHKTKSHKHKDKSKNKFEELSKDDYFSKNNEFASWLKDKKNLFFSDLSSETARNLFSDFVIQWNKGKLDSQYYEGIATGPRSSHAWNIKK", "function": "Component of the auxin signaling transduction pathway that regulates cell proliferation and differentiation during flowers stigmas and styles development. Involved in the regulation of auxin-related genes.", "AFDB_id": "AF-A0A1S3XQD6-F1-model_v4" }, { "swissprot_id": "B1X3S1", "sequence": "MYGYPVTTVFPPVSIEDFLSLSIGHWISLRSQFKCSSIDDNWHSSERGDIKLALGPSDNSNTRNLAISMGSQYAMKLEFFLDGRLQSENCIIGTWQIWPDGSLELSYHDANGNEQCERIWFMKTNLRLRSTVAFNQDGTLRQASFCSEIRRVTKHKL", "function": "Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.", "AFDB_id": "AF-B1X3S1-F1-model_v4" }, { "swissprot_id": "F4JTP5", "sequence": "MVMEDNESCASRVIFDALPTSQATMDRRERIKMEVFDEVLRRLRQSDIEDAHLPGFEDDLWNHFNRLPARYALDVNVERAEDVLMHKRLLHSAYDPQNRPAIEVHLVQVQPAGISADLDSTSNDAGHSSPTRKSIHPPPAFGSSPNLEALALAASLSQDEDADNSVHNNSLYSRPLHEITFSTEDKPKLLFQLTALLAELGLNIQEAHAFSTTDGYSLDVFVVDGWPYEETERLRISLEKEAAKIELQSQSWPMQQSFSPEKENGQTGARTHVPIPNDGTDVWEINLKHLKFGHKIASGSYGDLYKGTYCSQEVAIKVLKPERLDSDLEKEFAQEVFIMRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPTLFKVAIDICKGMSYLHQNNIIHRDLKAANLLMDENEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLTGKLPYEYMTPLQAAVGVVQKGLRPTIPKNTHPKLAELLERLWEHDSTQRPDFSEIIEQLQEIAKEVGEEGEEKKKSSTGLGGGIFAALRRSTTHH", "function": "Serine/threonine protein kinase that specifically phosphorylates chloroplast precursor proteins in the cytosol within the cleavable presequences (transit peptides). May be part of a cytosolic regulatory network involved in chloroplast protein import. Does not phosphorylate mitochondrion precursor proteins. Specific for ATP and does not utilize other NTPs. Plays a role in chloroplast biogenesis and differentiation in cotyledons, possibly through phosphorylation of chloroplast preproteins.", "AFDB_id": "AF-F4JTP5-F1-model_v4" }, { "swissprot_id": "O45405", "sequence": "MPTFSLWLPAGSNNVHPCGDPYAHHLFMRCLYHAKHDPTMKFDVKTTNVNKTSQEFKNTGLRRMPGISAEESGETQTFETEDDILDFLEYLKPERGDDEEAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPRLSAKDRAKLVREEPVFSFSV", "function": "Probable chloride channel.", "AFDB_id": "AF-O45405-F1-model_v4" }, { "swissprot_id": "H6S3X4", "sequence": "MRGSTAMLLAAIALFSSQSFATAIGKSRTLRSFEELEERQLASGSGSNNGLDDVKRSALVELLGEKVVAGGPTSILKAMMKLSDEELQNFIDKNIGSDSDSASGGN", "function": "Effector that may act as a suppressor of cell death to interrupt plant immunity. I.", "AFDB_id": "AF-H6S3X4-F1-model_v4" }, { "swissprot_id": "Q6CN41", "sequence": "MSVCQTNPLNTLVSKSGYRFGQPNQHQQSIAQQQSRPRNNALDHQFSQFTGASGPSFAHPQHQQLPMAAVVANATTAASTTSNTATASDHHVWIDQFANMQVHDKTEFPTDYKQMYSQYEARGASYSMGAPVMVSHSQMFPRHQQSLMVNQLESQAYASSSAKLDEQFAELERQVQDDEKEQQQDKDDDFHLKETSPLDEDQRQLKEAAQSIYTTLSDKSSTTSSKFSNSKFLGLMRNISDGVITLKKNPDEDKYTELYSPSTGETFGEEYFPVQDSVLGDPLDSIGDLSNMSSSEAAAKVYHNSV", "function": "Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins.", "AFDB_id": "AF-Q6CN41-F1-model_v4" }, { "swissprot_id": "Q8VI84", "sequence": "MKARRNKKQVPSFRKLIKTSKVKLENKLKNKQFKQQSTIKKYRKEQRKLRQAVKDAVSKKPIPLEDPKSKRPVKRMEREEDEEEEALPLDMMDEDDLQLMKDLGQKASFLTRDLSSSEPVHIKKRKHESVIEKYEKVPRTLQTAPEKELIHLLPIKDKSGIIPQAREKPVTDVQQEEEAEEELEDEEEVIEDPRKELTIEEHVIERKKKLQDKKIQIAALASAILSDPESHIKKLKELRSMLMEQDPDVAVTVRKLVIISLMELFKDITPSYKIRPLTEAEKSTKIRKETQKLREFEEGLVSQYKFYLENLEQIVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDGSKPVSEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKRFMTFKEKRKTLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQKSPLLPAVLEGLAKFAHLINVEFFDDLLVVLHTLIESGELSYQESLHCVQTAFHILSGQGDVLNIDPMKFYTHLYKTLFTLHAGATNDGIEIVLHCLDVMLSKRRKQVSHQRALAFIKRLCTLALQVLPNSSIGLLATTRILMHTFPRTDLLLDNESQGSGVFLPELEEPEYCNAQNTALWELHTLRRHYHPIVRRFAAHLLAGAPSEGSEALKPELSRRSAVELFETYSMAAMTFNPPVESSHSKRKDKFLPGDSFLNEDLNQLIKRYCNEAAPETPLDFAKCLESSSRQYRVNGLS", "function": "May be required for adipogenesis.", "AFDB_id": "AF-Q8VI84-F1-model_v4" }, { "swissprot_id": "Q0GNC1", "sequence": "MSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCSQQYRFSVIMSELSDSDNVPYVVTLLSVINAIILGPEDLRSRAQLRSEFIGLQLLDILTRLRDLEDADLLIQLEAFEEAKAEDEEELQRISDGINMNSHQEVFASLFHKVSCSPASAQLLSVLQGLMHLEPAGRSGQLLWEALENLVNRAVLLASDAQACTLEEVVERLLSIKGRPRPSPLDKAHKSVQTNSVQNQGSSSQNTTTPTTKVEGQQPVVASPCQHVGSIQSSSVDIAPQPVALEQCITALPLPTPPLSSSTPVLPPTPPPLPGPGATSPLPPPPPPLPPPLPGSGTTSPPPPPPPPPPLPPPLPGSGTISPPPPPPPPPLPGTGAVSPPPPPPLPSLPDSHKTQPPPPPPPPLPGMCPVPPPPPLPRAGQIPPPPPLPGFSVPSMMGGVEEIIVAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATLGSPCTAAVEPDFSSIEQLFSFPTAKPKEPSAAPARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTSMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPLRVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPPSQAAGINVEIIHSEASANLKKLLEAERKVSASIPEVQKQYAERLQASIEASQELDKVFDAIEQKKLELADYLCEDPQQLSLEDTFSTMKTFRDLFTRALKENKDRKEQMAKAERRKQQLAEEEARRPRDEDGKPIRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTEASGRVAPTDPPKATEPATASNPTQGTNHPASEPLDTTAADEPQGWDLVDAVTPSPQPSKEEDGPPALERRSSWYVDAIDFLDPEDTPDAQPSEGVWPVTLGDGQALNPLEFSSNKPPGVKSSHQDATDPEALWGVHQTEADSTSEGPEDEAQRGQSTHLPRTGPGEDEDGEDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVQGRVSKGTSKRRKKRPSRNQEEFVPDSDDIKAKRLCVIQ", "function": "Severs actin filaments and accelerates their polymerization and depolymerization.", "AFDB_id": "AF-Q0GNC1-F1-model_v4" }, { "swissprot_id": "Q75AF5", "sequence": "MFKQLSQFGKNITDELAKGINEDTASEGQHGAGAQGGRREEGGSPYEELPKEIQAKLRKFEKYEQKYPLLLNAYKAEKEKSDEVELLLKVLSENTPVSAIGDVETLRGFFEDVGVKTAMLTEEIKRITGENNGLQKQLAEAQESLEQRQRDLTSREEELAKSSREATELRELRQQAVAEKDAAVTERDDAQKAAAEMETRCTEAEAHAAEMKSQIESMETELKRTEKLLTTYKSTIQELGASQATGEAQPSSEAPSVRGKKGKGKRGKGKKRVQAADEKADTSSELELGEEKTPSTSSAGDEIIEAIETKQKYENLVEEHQQLSLELEKSRHWEQECLDSRKKVETLETELKDVKAKLKNSNEELETVRGMLKTVGNELVHARDELKQLNCEGTNEVERLKSELQELRTENSTQIATLKEQLQLLNDQKKALETDVEQHKRKMEDLESELLKSQENVSKFRNQNNDLSEKLRDYIVLKKSEATTRMSLSQKEKTIEYLEEQVRQYNSKEIEDKKAFADSKTELERWQRTAANLEKQLERIRLETKRHDDNLESYIKENGKLSERLEVLQEKYDSLQNLKSNSGDQVSAIRKQCEELNSKLKEATKRVMSLEDELNETSTVLQERTREATTMRRMINSDRSSKDTKIRELEDRVAAASEERDKLKSELDVLLARKNHETQDLKNTNQELVVKINALELKEQELATEVQQLKVLNQTIRRHSSTAADGSEELELTVRKLKDSLRTSEKKMRELKDSNEELKSLNDELNAKLDRLANRYKVLSTQLKMSKDMSSQSRHSSRSGSLVSPSSDNETGNSPRKISISSAHPAPVVASYDNSAEMESNEKLAYIRNVLLGFLEHREQRSQLLPVVSTLLQLSSHDEKRLLTSLK", "function": "Involved in vesicular transport between an endosomal compartment and the Golgi apparatus.", "AFDB_id": "AF-Q75AF5-F1-model_v4" }, { "swissprot_id": "P30420", "sequence": "MTKYRIITFDGGGTLGALSLQLLNRLAYQNPKLISETNVFSGNSIGSFTALALASGRSPEETFDFFKDQILPAFSVSRPGGPVFNQQVPYSGLIKAIRTFFPRDLRLRDLKKRIVVPAFHLFAPELNRWNPVLFHNFLGSPYLNEKASDVILRSSAAPATQRAYQNYVDGYTVATNTSTASIAFAVGKAKQPLDQIAVLSIGTGEQPTQLRRDTKGWGMVSADNILPEDMEDLPPNWGVLLDRSPNEPLLPFLQIISGGSSYYESMVSSELLGDQFFRLNPRIPNFSKTDPSVVPALISIANKTNLRPAFQFIERNWN", "function": "Probable lipid hydrolase.", "AFDB_id": "AF-P30420-F1-model_v4" }, { "swissprot_id": "Q9LBW6", "sequence": "MATPTPFQSQIYRSLPEIERADAIVERISKAIALGLLKVGERLPPEAALSEMFGVGGATLREALSELRERGVVETRRGRSGGTFVVNQPEPETDIMREWFLSTSISEIRDIGDEHSAIAAATIRLACERAEAHDFDRLQELARALVLAETPETRASADSRFHIELAVSAQSPRLANAEIRLQEETVRQLWAPFTVAEAYDPERATAEHLELVRAVAQDQPERAQKLTLEHIRRNIFHLIDTKLVLGYAQSRPSSPATAPDGSSSAEAAMIQEGQ", "function": "May regulate the transcription of the rmpAB operon.", "AFDB_id": "AF-Q9LBW6-F1-model_v4" }, { "swissprot_id": "Q9CCP6", "sequence": "MQAPKHHRRLFAVLATLNTATAVIAGCSSGSNLSSGPLPDATTWVKQATDITKNVTSAHLVLSVNGKITGLPVKTLTGDLTTHPNTVASGNATITLDGADLNANFVVVDGELYATLTPSKWSDFGKASDIYDVASILNPDAGLANVLANFTGAKTEGRDSINGQSAVRISGNVSADAVNKIAPPFNATQPMPATVWIQETGDHQLAQIRIDNKSSGNSVQMTLSNWDEPVQVTKPQVS", "function": "Constitutes a host TLR2 agonist (toll-like receptor) able to stimulate proliferation of CD4+ T-cells derived from a human leprosy patient following protein processing/presentation by MHC class II molecules in peripheral blood mononuclear cells.", "AFDB_id": "AF-Q9CCP6-F1-model_v4" }, { "swissprot_id": "Q03846", "sequence": "MKKTLLGSLILLAFAGNVQAAANADTKGTVTFFGKVVENTCQVKTDHKNRSVVLNDVGKNSLKDKGNTAMPTPFTITLQNCNLTAANSSTNKANKVGLYFYSWENADKENNFTLKNKTSTSNDFATMVNIQLMESDGTKEIKVVGKETEDFVHKNATGAGVALTQTHPDNDHISGSTQLTGVTGDLPLHFIAQYYSLGSTTAGKVQSSVDFQIAYE", "function": "Mediates adherence to oropharyngeal epithelial cells. Helps the airway colonization process.", "AFDB_id": "AF-Q03846-F1-model_v4" }, { "swissprot_id": "Q08422", "sequence": "MSDINEIEIPSRKDEIRQVTPKDPMHEIEDKSTYHAKIKKSDSGTVLGAIPLNSRSSSNSSVTSTGQSSRRVTKKTTKKKKKNACYFDTCSSAASKFIGDCNFCKGHFCSKHRLMENHACNGLTSCKEQLHQRNADKLEAEQTKAPKIQI", "function": "May have a role in protecting cells from metalloid-induced proteotoxicity.", "AFDB_id": "AF-Q08422-F1-model_v4" }, { "swissprot_id": "Q5RI15", "sequence": "MAAPPEPGEPEERKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN", "function": "Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme.", "AFDB_id": "AF-Q5RI15-F1-model_v4" }, { "swissprot_id": "Q8ZNR6", "sequence": "MDSNHSAPAIVITVINDCASLWHEVLLGIEEEGIPFLLQHHPAGDIVDSAWQAARSSPLLVGIACDRHSLVVHYKNLPASAPLFTLMHHQDSQAQRNTGNNAARLVKGIPFRDLHA", "function": "The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.", "AFDB_id": "AF-Q8ZNR6-F1-model_v4" }, { "swissprot_id": "Q9Z254", "sequence": "MPLGLGRRKKAPPLVENEEAEPSRSGLGVGEPGPLGGSGAGESQMGLPPPPASLRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPAAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIQLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSSGGHPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY", "function": "May be involved in G protein-linked signaling.", "AFDB_id": "AF-Q9Z254-F1-model_v4" }, { "swissprot_id": "O31983", "sequence": "MEMDITQYLSTQGPFAVLFCWLLFYVMKTSKERESKLYNQIDSQNEVLGKFSEKYDVVIEKLDKIEQNFK", "function": "May be involved in the secretion of the autolysin BlyA.", "AFDB_id": "AF-O31983-F1-model_v4" }, { "swissprot_id": "P37894", "sequence": "MGRHGGPAAAGPTAPSAVRAKAVNAPSQVFVRIAILAALLLLAVYTAFGVHRLQREAMAQPGGAPLAAKADLIAGRVDANLAAQRAGLSAAADLLKRDPGATMDAAETTLRAAGGEAAAVAVVSEAGVVAVAGRDDGADWKAAALAAGASGRTNWVGSVGETGRLYVATTTSLDRARAFVIASGDASRLVADPEKGESGALALPDGKLIAARGRGVQGAGALREAFALSIEDLGDGPAAVRGQAADGALLDVAVRPVAQGALLAVAAAPTRSVANLDRQVMEGAFSLLVPLGVGIALALLLMIQSRKAEVAHREFIDSERRFRLAVEAARCGIWEWDLNGDQVYLSDVTGAMFGWGGGGVVSGQDLLERISIDHRERVRQALANAAMYGAFDVSFRVPASEQGARSLWIDARGQGFGKPGSEGHARIIGVALDVTEERIAQARAQAAENRLRDAIESVSEAFVLWDRQGRLLMCNRNYRSVFSLEPKILKPGAARAEVNRFAALAIKQDHPAPDGAKGVREAEMMDGRWIQISERRTAEGGLVMTAADITAIKTQEEARRRNEEQLQNAVAGLERSQEQLAELARKYETEKVKAESANKAKSEFLANMSHELRTPLNAINGFSEIMMNEMFGPLGDQRYKGYSQDIHSSGQHLLALINDILDMSKIEAGKMNLKFESMHLEDVAEDAVRLVRNRAEAAGLKLDIDFPQLPEIEADYRAVKQVLLNLLSNAIKFTPRAGSVTVRAEVRRDPFGDLIKVSVTDTGIGIAKEDLARLAKPFEQVESQFSKTTQGTGLGLALTKSLITMHDGVLEMHSTPGEGTTVSFTLPVRHSDQKITRDFVAA", "function": "Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator PleD, leading to its activation.", "AFDB_id": "AF-P37894-F1-model_v4" }, { "swissprot_id": "P25364", "sequence": "MMNEDISIIDGHNSFLTEKSTVLLTQAKRTLEDEKEMITPPSSTVRKTMKEVNKRPSHPLSPDHSSPIAPSKAKRQRSDTCARSNGNLTLEEILQSLERRRINGELAKKPPYSYATLICLAILQSQEGKLTLSQIYHWIHVHFPYYKQKDASWQNSIRHNLSLNDAFIKTEKSCDGKGHFWEVRPGAETKFFKGENRGYEFVKDSLQDIGKYFEIDSTLDELEQVESGEGNDDLPDEEEREEAGKFPSIEIQLNSSPILRVSQLHHIPQLKTDNSVLNPHENLESMRNMIENDVNNIDSLEPPYVMKKYHTSLGLPSLVNAKDHFQAGVKNNNITQANRFNTLPITSAKSPQNFRKYFTSFNSNFEDLSPLRSNVGAGSLLDPLPYSPLKLYDQKNLALMSKPQSQQSYSNSQLPPPPSSHGSDLLKTPKMRHSDGLEKTPSRLISTPKDGNSILRKWQTPSHLFEDLYCSPLFRAIETPIRYITTPGGTLETQISPRKSSAPDVLTSATNSKFASSGLFGVDVYSVWKRATEKISDGNNTTDSNQKHHPYHNHPSNDSGNEKN", "function": "Transcription factor regulating the cell cycle specific transcription of a spindle pole body (SPB) calmodulin binding protein SPC110. Required for full induction of SPC110 transcription in late G1. Binds to DNA consensus sequence 5'-[AT]AA[TC]AAACAA[AT]-3'. Dosage dependent suppressor of calmodulin mutants which have specific defects in SPB assembly.", "AFDB_id": "AF-P25364-F1-model_v4" }, { "swissprot_id": "Q40849", "sequence": "MSISSKFQLRSSTSLLLLVALMVVMGMDGAAAAPNTNFVSSACNTQKIPSGNPFFTNLRAMLADLKQNTAFSGFDYKTSRAGSGGAPTAYGRAICKSSISQSDCSACLSNLVGRIWGICSNAIGARVQLTDCFIQYEQHSF", "function": "Exerts antifungal activity through its carbohydrate-binding specificity.", "AFDB_id": "AF-Q40849-F1-model_v4" }, { "swissprot_id": "Q6M0M3", "sequence": "MIITTSRKPSQRTRSLVNDLARVFNFKILNRGKIPLSELIENKDDMIIVEELKGNPGRLKIFNFENNKILSMNLSLKLQREVSGKAFKNSGKLGSKFDKNTEHLKEFFFEYLFKKLSNYKEENFEVVITFKTVDESTFYIEVHKGSENMGPSLKIKTVKILDIE", "function": "Probably involved in the biogenesis of the ribosome.", "AFDB_id": "AF-Q6M0M3-F1-model_v4" }, { "swissprot_id": "A4ISB9", "sequence": "MQNFTFRNPTKLIFGRGQIEQLKEEVPKYGKKVLLVYGGGSIKRNGLYDEVMSLLTDIGAEVVELPGVEPNPRLSTVKKGVDICRREGIEFLLAVGGGSVIDCTKAIAAGAKFDGDPWEFITKKATVTEALPFGTVLTLAATGSEMNAGSVITNWETKEKYGWGSPVTFPQFSILDPTYTMTVPKDHTVYGIVDMMSHVFEQYFHHTPNTPLQDRMCEAVLKTVIEAAPKLVDDLENYELRETIMYSGTIALNGFLQMGVRGDWATHDIEHAVSAVYDIPHAGGLAILFPNWMKHVLDENVSRFAQLAVRVFDVDPTGKTERDVALEGIERLRAFWSSLGAPSRLADYGIGEENLELMADKAMAFGEFGRFKTLNRDDVLAILRASL", "function": "Long-chain alkyl alcohol dehydrogenase that can oxidize a broad range of alkyl alcohols from methanol to 1-triacontanol (C1 to C30) as well as 1,3-propanediol and acetaldehyde. Oxidizes isopropyl alcohol, isoamylol, acetone, octanal and decanal. The best substrate is 1-octanol.", "AFDB_id": "AF-A4ISB9-F1-model_v4" }, { "swissprot_id": "Q2HJA2", "sequence": "MGPRNPSPDPLSESESEEEENTNYLNESSGEEWDSSEEEDPVVPNLTPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDASTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLISPSRLSRDHATLNGALQFATKQLSRTLSRATPHAFLPKLVPLAFSS", "function": "Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.", "AFDB_id": "AF-Q2HJA2-F1-model_v4" }, { "swissprot_id": "A1WSH4", "sequence": "MGALRPQPPRMPAGHVAPAYWQKRGLAAWALWPLAQLYRALVAARRGLYRAGWLKAQHPGRPVIVVGNVIAGGAGKTPVVIALARHLQARGLRVGVIARGHGRSRRDCRAVLPDSPASAVGDEPALIARHFANGPAVPVFVARRRISAARALLAAHPDTDVLLCDDGLQHLALRRDLEICVFNDQGLGNGFLQPAGPLREPWPRSVDFVLHAGAAPGGSPAPAFGVQRSLAPCALRSDGAAVPLARLQGQPLHALAAVARPGEFFAMLQARGLTLAHTEALPDHYDLQRWERMTDPRLTLICTEKDAVKLWPLHPDALAVPLVLHIDPGFFAALDAWLPARRAMPEIAPGSDAAAIIAGTEPTLPENHRPMDPKLLQLLVCPVTKGPLRYDRAAQELISRSARLAYPVRDGIPVLLENEARPLTDEELEQ", "function": "Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).", "AFDB_id": "AF-A1WSH4-F1-model_v4" }, { "swissprot_id": "Q54DA9", "sequence": "MDGVEIIAKSIKNSAIEKVFGIVGVPITPIAYELQAQGVGFFGFRNEQSCSYAASIVGYLTGLPGLCMTVSGPGVVHALAGVLNAQSNGWPMILLSSSIDQSLVGKGGFQECKQFESAELYCKKCYYLTEIDHFPEILKDAIETSLSNRPGPVYIQIPADLIKSKCKESPNIREAAGYGTIAIKSVVPDMKLIKDAVQLLSEAKRPLVIGGKGAAYCRSENELLEFIEATKIPFLPSPMGKGLLRDDHPLVVGAARSYALKNADVVLVLGARLNWMFNFGKAPTFSTDVKFIIVDVDENQASKTKNPNVVPEIAIVGDARLSIAEMRKLFIGETDEQPQPPQDSLIKSMKMEESWWSNLNQDIQVKTKSLATLMSEPQNNDQEYLTYHKVFNALRVGGLFQEDTIFVNEGANTMDIGRLCIPQTLPRSRLDAGTLATMGVGVGYSVAAQICFPDRSVVCIQGDSAFGFSAMEMEVAVRYKLPIVFIVLNNNGVYEGLESMSDPKYTSSTESASLHIPPTSLSVDTKYELIMQSFGGTGYSISTISNLLDICKQIKSKQISLPTLLNIKIKPTGTKPKIVH", "function": "Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids and the shortening of 2-hydroxy long-chain fatty acids.", "AFDB_id": "AF-Q54DA9-F1-model_v4" }, { "swissprot_id": "Q2UPA7", "sequence": "MSKRIRLGIVGLSADPSHCTNYIHKIPLTTTPLKEKYEITAVSMSSPEKAEAAAIAHGLPRERGYHSVESLAKDPDVDLVVVSVKVPRRAELAMAAIEAGKDVYVEWPFASNLAAAEALAQRARERQVKSMVGLPTRLAPQVLKMKEILRSGSLGRILATNLLVTDDLFLKFHADKRHSHDKTNGANIVTIAGGHLLDAMAFLLGEFTTLHAHTSMLFPKPVLCDTDGNLKTGQFNDSPDTFTMHGKIGISEVPVSVCMYSHPPTTPNLFQWVITGEKGSLKMEGPSLMIHAIPPKLMMTSFGSETVCWEEISLENTIVSGAEYQAWLDNDTERIVTLDEAVVRYRMVDAILRSAESGQCTSYRYD", "function": "Dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells. The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues. One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine. After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT. In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine. Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway.", "AFDB_id": "AF-Q2UPA7-F1-model_v4" }, { "swissprot_id": "O61955", "sequence": "MSTSVAENKALSASGDVNASDASVPPELLTRHPLQNRWALWYLKADRNKEWEDCLKMVSLFDTVEDFWSLYNHIQSAGGLNWGSDYYLFKEGIKPMWEDVNNVQGGRWLVVVDKQKLQRRTQLLDHYWLELLMAIVGEQFDEYGDYICGAVVNVRQKGDKVSLWTRDATRDDVNLRIGQVLKQKLSIPDTEILRYEVHKDSSARTSSTVKPRICLPAKDPAPVKEKGPAATTSPSNPGTEATGTSPATPTP", "function": "Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps. Ife-3 is essential for viability. Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively. Within the pid-1 variant of the PETISCO complex binds to capped 21U-RNA precursor molecules, possibly playing a role in the processing of the 5' end of the molecules to promote binding of other complex components such as pid-3. However, it is not essential for the biogenesis of 21U-RNAs by itself. Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing.", "AFDB_id": "AF-O61955-F1-model_v4" }, { "swissprot_id": "I6Y9F7", "sequence": "MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGSPCAIGWVAGWLSAEFPARVVTGHALSRISPRSIGRFGTSWAAQRADQILHAALVDAFGPDFRDLVWHPTGEQSEAARRSGLLNLPHIPGPHRRYAAQTSDIPYGPGGRENLLDIWRRPDLAPGRRAPVLIQVPGGAWTINGKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAHIVDVKRAIAWVRENIADYGGDPDFITITGGSAGAHLAALAALSANDPALQPGFESADTAVQAAAPYYGVYDLTNAENMHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYVHSEAPPFFVLHGEKDPMVPSAQSRAFSAALRDAGAATVSYAELPNAHHAFDLAATVRSRMVAEAVSDFLGVIYGRRMGARKGSLALSSPPAS", "function": "Shows lipase activity. Is highly immunogenic and may play an important role in the virulence and pathogenesis of M.tuberculosis infection, by altering the balance of cytokines. Significantly down-regulates the expression level of pro-inflammatory cytokines (TNF-alpha and IFN-gamma) and up-regulates the level of anti-inflammatory cytokines such as IL-4 and IL-10 as compared to LPS stimulated macrophages. Also inhibits the expression of iNOS, TLR2 and transcription factor NF-kappa-B in LPS stimulated macrophages whereas the expression of TLR-4 remains unchanged.", "AFDB_id": "AF-I6Y9F7-F1-model_v4" }, { "swissprot_id": "B7XJI2", "sequence": "MSISYNVFDIAVNPTYYSFEKLKLIVEKAKELKILPLFIGLDMETNIQVIHLSKMQQTLCYCGIHPTHINTLYKENNIWNILDIVQADLKQLFVENSEYIIAIGECGLDYYRNQLKIEQQRIFKMQLELSYLNIPYFLHMRNAFDDFYNIIKNYTNVTGVIHSFDGTVDQALALINLGFYIGINGCSLKNNIDLVKNIPIDKILVETDSPFCLIRKSYAGAEYGKVLKVKENEPVYILNLIEIISNIKQMPIQQLIHQFKLNTIKCFPQLKKFQ", "function": "Putative deoxyribonuclease.", "AFDB_id": "AF-B7XJI2-F1-model_v4" }, { "swissprot_id": "Q98QK2", "sequence": "MKIAIVIDSSSGLTKEQANKRGWYFLPLNIDIDEKTYKDGIDLDNKNFFEIFKKNSKTSTSASSRGEIISLFDDITSKYDKVVVFPISYKLSSQYQNLDLIAREYKNIHIVKSKHLSFLTIVQLIKFEKAIGQNQSFDEELKKLSHWDESQKVLLIPEYNDALVAGGRLSPKAAALAKVLKVVPIIKFENGELLKEGKGISFQKTLTKLISSLSGKYSKDSKNYFPVILHAQNSNISFYEEHFLNEFGKKPLILSLPSVISVHTGLGAIAISLVKVDKDVIDQIVEHF", "function": "May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.", "AFDB_id": "AF-Q98QK2-F1-model_v4" }, { "swissprot_id": "Q09476", "sequence": "MPSDDRFADAVKPALEALLSDLQHTTEVLRRAHISDRRSQSRDDFEQSYDLQGNLNTQSVSNGNITTSPYKRRSSEGKDYSKSQERIYENESRLNPPVYSRPSVQSLLSQVEEPPIRASSSRKSLGPPSQAQSYSDVRSNGRSPSRDPLHSDSMIGTMNGELSSKHGVNTIPKGDCAACGKPIIGQVVIALGKMWHPEHYTCCECGAELGQRPFFERNGRAFCEEDYHNQFSPKCQGCHRAITDRCVSVMNKNFHIECFTCAECNQPFGEDGFHEKNGQTYCKRDFFRLFAPKCNGCSQPITSNFITALGTHWHPDCFVCQHCGVSFNGASFFEHNGAPLCERHYHESRGSICSQCRGAINGRCVAAMGRKFHPEHFRCSYCNHQLTKGTFKEVDRRPFCHKCYNNTYALTPA", "function": "Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles.", "AFDB_id": "AF-Q09476-F1-model_v4" }, { "swissprot_id": "O33813", "sequence": "MQVLWKKFQKKLIDANLAECGIEIGVPNVGYNYTVFQKSVLHIVTQGEGTFSYAGETYHLTAGDIFLLERGMEVEYKPSFSNPWTYYWVGMNGKQILNYLSRCSIVDSHVILGQDTTDIKNIIQLICKLSQSIESNNSNDILIMQYLYQLVYTLQEKFPKIFSVQVDIVNEDIQHAVDFINTNYQKHITVEDVAKSVNITRSHLYKLFKKNLGCSPKEYLTYIRMYHASQLLIHTSTLISDISRQVGYKDPLLFSKNFTKHFEISASEYRHHFSINNKQ", "function": "Transcriptional regulator of the lacPH genes for lactose utilization.", "AFDB_id": "AF-O33813-F1-model_v4" }, { "swissprot_id": "Q8LN68", "sequence": "MLPFFDSPSPMDIPLYQQLQLTPPSPKPDHHHHHHSTFFYYHHHPPPSPSFPSFPSPAAATIASPSPAMHPFMDLELEPHGQQLAAAEEDGAGGQGVDAGVPFGVDGAAAAAAARKDRHSKISTAGGMRDRRMRLSLDVARKFFALQDMLGFDKASKTVQWLLNMSKAAIREIMSDDASSVCEEDGSSSLSVDGKQQQHSNPADRGGGAGDHKGAAHGHSDGKKPAKPRRAAANPKPPRRLANAHPVPDKESRAKARERARERTKEKNRMRWVTLASAISVEAATAAAAAGEDKSPTSPSNNLNHSSSTNLVSTELEDGSSSTRHNGVGVSGGRMQEISAASEASDVIMAFANGGAYGDSGSYYLQQQHQQDQWELGGVVYANSRHYC", "function": "Probable transcription factor that functions as a negative regulator of lateral branching, presumably through its expression in axillary buds. Involved in the fine tuning of shoot branching. May function as an integrator of multiple signaling pathways to regulate the development of axillary buds. Works partially downstream of strigolactones to inhibit bud outgrowth. Binds to MADS57 to suppress the negative regulation of D14 by MADS57 and balance the expression of D14 for tillering.", "AFDB_id": "AF-Q8LN68-F1-model_v4" }, { "swissprot_id": "A1TAP4", "sequence": "MTWPNRDQPAFPSSSSGAFSALPQGVSHGGVNLSSFSDFLRHQAPHLLPGAPGPGPTGLPTDAVPHGTTIVALKCPGGVVMAGDRRATQGNMIASRDVQKVYITDDYTVTGIAGTAAIAVEFARLYAVELEHYEKLEGVALTFPGKVNRLATMVRGNLGAALQGFVALPLLAGYDLDDPNPEAAGRIVSFDAAGGWNFEEEGYQSVGSGSIFAKSSMKKLYSQVTDAESALRVAVEALYDAADDDSATGGPDLVRGIFPTAVVIGADGAHEVPEAKISSLCREVVENRSRTETFGPDARPTRGDEL", "function": "Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.", "AFDB_id": "AF-A1TAP4-F1-model_v4" }, { "swissprot_id": "Q4ADV8", "sequence": "MKQEQVRMAVLLMLNCFVKATAPPPWPPSASSASFLDDLGDLGIAPLIRADEAGTARASADFGNLSVAGVGAPRLAAAAAVLYPSRPADIAALLRASCARPAPFAVSARGCGHSVHGQASAPDGVVVDMASLGRLQGGGARRLAVSVEGRYVDAGGEQLWVDVLRASMAHGLTPVSWTDYLHLTVGGTLSNAGISGQAFRHGPQISNVLELDVITGVGEMVTCSKEKAPDLFDAVLGGLGQFGVITRARIPLAPAPARARWVRFVYTTAAAMTADQERLIAVDRAGGAGAVGGLMDYVEGSVHLNQGLVETWRTQPQPPSPSSSSSSSFFSDADEARVAALAKEAGGVLYFLEGAIYFGGAAGPSAADVDKRMDVLRRELRHERGFVFAQDVAYAGFLDRVHDGELKLRAAGLWDVPHPWLNLFLPRSGVLAFADGVFHGILSRTPAMGPVLIYPMNRNKWDSNMSAVITDDDGDEVFYTVGILRSAAAAGDVGRLEEQNDEILGFCEVAGIAYKQYLPYYGSQAEWQKRHFGANLWPRFVQRKSKYDPKAILSRGQGIFTSPLA", "function": "Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group. Is a major QTL involved in grain yield. Modulates the number of reproductive organs by regulating the cytokinin accumulation in inflorescence meristems. Acts as negative regulator of panicle branching.", "AFDB_id": "AF-Q4ADV8-F1-model_v4" }, { "swissprot_id": "P40976", "sequence": "MSQTAPSDTEYNQRLERWSERLKSQTISHLPTDYSRPVPSRLVEAVFERTLPEDAKTALIKVYVAAQAKGILVTPFNILLTIFIILVSRMTGDEDISIGTSSENAIPFVLRTFIQPSDSFLDLLAKVCDLEKEGSSDAVDFSDLINFLNAKLSKKDDPRKTLVHLRFYNAPDAPSENFLSTTGLDVDLTVLVSVKKPSDQLTSLRSQFTFPDLQLKLIYNQLLFSESRVNIVADQLLKLVVSASKDVTGPIGALDLMTPTQMNVLPDPTVDLDWSGYRGAIQDIFASNAAKFPDRECIVVTPSVTIDAPVTSYTYRQIDESSNILAHHLVKNGIERGDVVMVYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPARQIIYLSVAKPRALVVLEDAGVLSPTVVEYVEKSLELKTYVPALKLAKDGSLTGGSVSKGADDILQHVLHLKSEQTGVVVGPDSTPTLSFTSGSEGIPKGVKGRHFSLAYYFDWMAQEFNLSESDRFTMLSGIAHDPIQRDIFTPLFLGASLIVPTAEDIGTPGQLAQWANKYKVTVTHLTPAMGQLLAAQADEPIPSLHHAFFVGDILTKRDCLRLQVLANNVNVVNMYGTTETQRSVSYFVVPARSQDQTFLESQKDVIPAGRGMKNVQLLVINRFDTNKICGIGEVGEIYLRAGGLAEGYLGNDELTSKKFLKSWFADPSKFVDRTPENAPWKPYWFGIRDRMYRSGDLGRYLPTGNVECSGRADDQIKIRGFRIELGEINTHLSRHPNVRENITLVRRDKDEEPTLVAYIVPQGLNKDDFDSATESEDIVVNGLKKYRKLIHDIREYLKTKLPSYAIPSVIVPLHKMPLNPNGKIDKPALPFPDTSQLAAASRSHSKHGVDETLTATERDIRDIWLRIIPHATDVNKKASFFDIGGHSILATRLIFELRKKFAVNVPLGLVFSEPTIEGLAKEIERMKSGEMISVMDIGKEETREPEIEYGKDALDLVDLIPKEFPTSKDLGIDEPKTVFLTGANGYLGVFILRDLMTRSSNLKVIALVRASSEEHGLKRLKDSCTAYGVWDESWAQKISVVNGDLALENWGIEERKWNKLTEVVDYVIHNGALVHWVYPYSKLRGPNVMGTITALKLCSLGKGKSLSFVSSTSTVDTEYYVNLSNEITSKGGNGIPESDPLQGSSKDLHTGYGQSKWVSEYLVRQAGLRGLRGVVVRPGYILGDSKSGAINTDDFLVRMVKGCIELGLYPNINNTVNMVPADHVARVVTASAFHPEQGVIVAHVTSHPRLRFNQFLGTLSTFGFNTKLSEYVNWRIALERFVINESHDSALYPLLHFVLDNLPANTKAPELDDTNTREILKRDASWTNVDVSNGAAILEHEMGLYLSYLVAIGFLPKPTLEGKKLPEVKINEATLEKLASAGGRGGAPTH", "function": "Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.", "AFDB_id": "AF-P40976-F1-model_v4" }, { "swissprot_id": "P53163", "sequence": "MSLRILAKRSSSIWMKTRVTPALISPITITTRFNSTTTTAPSHKDDVRPVDPKISKIVQDISQLTLLETSSLINELKTVLNIPEISMPMGGFMAGAAGAGAGNVPSSTGEAGSGAEEEAKPEAKTVFTVKLDSFDTKTKAKVIKEVKGLLGLSLVEAKKFVEAAPKVLKENVAKDDAEKIKKTLEDLGAKVSLE", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.", "AFDB_id": "AF-P53163-F1-model_v4" }, { "swissprot_id": "Q96P67", "sequence": "MNNNTTCIQPSMISSMALPIIYILLCIVGVFGNTLSQWIFLTKIGKKTSTHIYLSHLVTANLLVCSAMPFMSIYFLKGFQWEYQSAQCRVVNFLGTLSMHASMFVSLLILSWIAISRYATLMQKDSSQETTSCYEKIFYGHLLKKFRQPNFARKLCIYIWGVVLGIIIPVTVYYSVIEATEGEESLCYNRQMELGAMISQIAGLIGTTFIGFSFLVVLTSYYSFVSHLRKIRTCTSIMEKDLTYSSVKRHLLVIQILLIVCFLPYSIFKPIFYVLHQRDNCQQLNYLIETKNILTCLASARSSTDPIIFLLLDKTFKKTLYNLFTKSNSAHMQSYG", "function": "Orphan receptor.", "AFDB_id": "AF-Q96P67-F1-model_v4" }, { "swissprot_id": "Q2UJ66", "sequence": "MHSYVRPNQFVALRLPSEFTKIQKIEPDSTVFLGKFGSFPANQIIGRPFYLTFEILDDADEKDGSCLRIIPAAELHAETLIAEGEGDGEELDTNEDGTPMRTNREIVDDASTQKLTWEEIEALKKESGGAGREIISKLLESHQTLDQKTSFSLAKYMLRKRRKYMKRFTVLPLDVSILTNHMMEDQGAARIMELRDEMVGLLGCWGNVHHGGDASLDEAIAAKPNGRYLVVDDTGGLVVAAMAERMGILYPHDGDEYEEQGSSDEPKKNEAEQAHDDEQPPTESSTHRPARPAHMSASGNSITVLHPNKQPNLSLLKYFGYSQDNPDETHPLHKHLKTISWLQLLDPNADPIYSEEPEIIPESELYTMKSNKRGAYYRKRNRWTRVQSVVNEARAGEFDGLIVATVMDPSSVLKYAVPLLAGSAHVAVYSPSIEPLTELSDLYSTAKKTAFINRRQQLREQKLQQSSDQPDANETELQDSDLSELMAEFYLDPTLLLAPTLQNSRVRPWQVLPGRTHPLMSMRGGAEGYIFHAVRVIPTQQTIQAAGNLSRKKRKVVTQETPTTAVDSGSGVDVEMKS", "function": "Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.", "AFDB_id": "AF-Q2UJ66-F1-model_v4" }, { "swissprot_id": "O13795", "sequence": "MFVPRQLNVRKIKAFTGKENNSIADGNNNKLKDEHYKHNEASKEPSHSISGGLMLNQQDRQLIEPLNPDFLSAVDSILEIYFHRERQKEKVHLAFLIQQDDFWKGIRPNPTQNNLKYALSYVTNALFHFDNSSHMVIRNENIVLPLDIPLYDRIIYVEPVPATLSNKSLLLAGKLRKYLKEFLPYVDAIGTPEGYAFVILYKKVDQSALSKLPVPPGWVLLTRKEWTNREEKYFENQLHLVKASSSDVSNSSNSFPENRYPKLTKVEKQMTKSVSKTSQTDKDEDNLDFTKNLLTRIKNLHPLTNKSTIHSLLSYVFSRQTQNIACEPMYIDYRKDETEAIIRWKTPLHAETCINAFRTQERKQNSHDDIRAHRKKGSSRPFLIAELITGEEEKNYWRMLKK", "function": "RNA-binding protein required for assembly of the holoenzyme telomerase ribonucleoprotein (RNP) complex. Specifically binds telomerase RNA ter1 and promotes assembly of ter1 with catalytic subunit trt1. Telomerase is a ribonucleoprotein enzyme essential that copies new telomeric repeats onto chromosome ends and functions to maintain cell division.", "AFDB_id": "AF-O13795-F1-model_v4" }, { "swissprot_id": "Q53EK2", "sequence": "MEKERQDGLSDKHKFILQYIMCRTAGVDNEQVRELVQEQYGETATVEDVINELNNSLHNFDFKIKRVQDQLDGRLTLHFQNLSGDPVSQMATPYPPVQIELMRKIIEWIMKCDDYQYSLTTLQIQKLSRKEMGLAPSVIESHLHTFERDGWLRQREGIWTFTNHALAELDAYLHNEYESNLYECNACREIVIAGYVCDCGYCLHVYCCKHLAHVNCINCNTPWANATVIGRW", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.", "AFDB_id": "AF-Q53EK2-F1-model_v4" }, { "swissprot_id": "Q26239", "sequence": "MKSYTALLAVAILCLFAAVGVSGKCTKNALAQTGFNKDKYFNGDVWYVTDYLDLEPDDVPKRYCAALAAGTASGKLKEALYHYDPKTQDTFYDVSELQEESPGKYTANFKKVEKNGNVKVDVTSGNYYTFTVMYADDSSALIHTCLHKGNKDLGDLYAVLNRNKDTNAGDKVKGAVTAASLKFSDFISTKDNKCEYDNVSLKSLLTK", "function": "Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also binds tightly to histamine, which is released by the host to induce wound healing.", "AFDB_id": "AF-Q26239-F1-model_v4" }, { "swissprot_id": "Q9VCY8", "sequence": "MDSATNLLEQQGSAADVSGGSHPAEVEVTTQARATFGMDAEGHATGEAVTTTTATLRREGSDEDIFEQVQMILRKRRGWGPEDSLSPNDLDILEYDDELVEEDDAGCPLPSTPEDTQLIEAEMTEVLKAGVLSDEIDLGALAHNAAEQAEEFVRKVWEASWKVCHYKNLPKWLQDNDFLHRGHRPPLPSFRACFKSIFRVHTETGNIWTHLLGCIAFIGVALYFISRPSVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCHSVEMGRLFSKLDYCGIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGVIPAIHYSIMEGWFSQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAFVHYHGISEMAMYRVMYSECTVPIEPITF", "function": "Adiponectin receptor. In insulin-producing cells, regulates insulin secretion and controls glucose and lipid metabolism.", "AFDB_id": "AF-Q9VCY8-F1-model_v4" }, { "swissprot_id": "O94284", "sequence": "MLTLNSTIKSVTGSFQSASMLARFASTHHKVLVVGGGSAGISVAHQIYNKFSKYRFANDQGKDTSLKPGEIGIVDGAKYHYYQPGWTLTGAGLSSVAKTRRELASLVPADKFKLHPEFVKSLHPRENKIVTQSGQEISYDYLVMAAGIYTDFGRIKGLTEALDDPNTPVVTIYSEKYADAVYPWIEKTKSGNAIFTQPSGVLKCAGAPQKIMWMAEDYWRRHKVRSNIDVSFYTGMPTLFSVKRYSDALLRQNEQLHRNVKINYKDELVEVKGSERKAVFKNLNDGSLFERPFDLLHAVPSMRSHEFIAKSDLADKSGFVAVDQSTTQSTKFPNVFAIGDCSGLPTSKTYAAITAQAPVMVHNLWSFVNGKNLTASYNGYTSCPLLTGYGKLILAEFLYKQEPKESFGRFSRFLDQTVPRRMFYHLKKDFFPFVYWNFAVRNGKWYGSRGLIPPHFPVN", "function": "Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone.", "AFDB_id": "AF-O94284-F1-model_v4" }, { "swissprot_id": "Q5RD97", "sequence": "MAQTVQNVTLSLTLPITCHICLGKVRQPVICINNHVFCSICIDLWLKNNSQCPACRVPITPENPCKEIIGGTSESEPMLSHTVRKHLRKTRLELLHKEYEDEIDCLQKEVEELKSKNLSLESQIKTILDPLTLVQGNQNEDKHLVTDNPSKINPETVAEWKKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLVRENLRLKAEVDNRSPQKFGRFAVAALQSKVEQYERETSRLKKALERSDKYIEELESQVAQLKNSSEEKEAMNSICQTALPADGKGSKGSEEDVASKNQGDSARKQPSSSTSSSSHLAKPSSSRLCDTSSARQESTSKAELNCSKNKDLYQEQVEVMLDVTDTSMDTYLEREWGNKPSDCVPYKDEELYDLPAPCTPLSLSCLQLSTPENRESPVVQAGGSKKHSNHLRKLVFDDFCDSSNVSNKDSSEDDISRSENEKKSECFSSPKTAFWDCCSTSYAQNLDFESSEGNTIANSVGEISSKLSEKSGSCVSKRLNSIRSFEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSLDLDGLSKSSQGSEFLEEPDKLEEKTELNLSKGSLTNDQLENGSEWKPTSFFLLSPSDQEMNEDFSLHSSSCPVTNEIKPPSCLFQTEFSQGILLSSSHRLFEDQRFGSSLFKMSSEMHSLHNHLQSPWSTSFVPEKRNKNVNQSTKRKIQSSLSNASPSKATKS", "function": "E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase.", "AFDB_id": "AF-Q5RD97-F1-model_v4" }, { "swissprot_id": "P75063", "sequence": "METRDVLIVGGGVIGCATAYELSQYKLKVTLVEKHHYLAQETSHANSGVIHTGIDPNPHKLTAKYNILGKKLWLNTYFKRLGFPRQKIRTLIVAFNEMEREQLEVLKQRGIANQINLEDIQMLSKEETLKLEPYVNPEIVAGLKIEGSWAIDPVLASKCLALAAQQNKVQICTNTEVTNISKQVDGTYLVWTNNETTPSFKVKKIIDAAGHYADYLAHLAKADDFEQTTRRGQYVVVTNQGELHLNSMVFMVPTIHGKGVIVSPMLDGNFLVGPTALDGVDKEATRYITKDAPCMLTKIGKHMVPSLNINNALISFAGSRPIDKATNDFIIRVAHNDPDFVILGGMKSPGLTAAPAIVREAVRLLNWKLTKKPNWNGKYNLPWI", "function": "Catalyzes the oxidation of glycerol 3-phosphate to dihydroxyacetone phosphate (DHAP), with a reduction of O2 to H2O2. The formation of hydrogen peroxide by this enzyme is crucial for cytotoxic effects of M.pneumoniae on host cells. Is involved in the metabolism of glycerol and is essential for glycerol utilization; glycerol is one of the few carbon sources that can be utilized by M.pneumoniae for growth. To a lesser extent, is also able to use glyceraldehyde 3-phosphate (GAP), an intermediate in the glycolysis pathway, as a substrate (but the structure of the product has not been elucidated). Therefore, in the absence of glycerol, GAP may serve as a substrate in the GlpO reaction to supply H2O2 during mycoplasma infection. Does not show any dehydrogenase activity with NAD(+).", "AFDB_id": "AF-P75063-F1-model_v4" }, { "swissprot_id": "P25307", "sequence": "MARTAATKLALVPLVAAMLLVAADAHHLRPGELCLGPLRRLRKRQRHQPSAGCCSGVKRLAGLARSTADKQATCRCLKSVPARTTPAGPQASPPGAASASPTRSAPVSTALRSTDRTRAPHISSDRRLVG", "function": "Possible dehydrative stress responsive protein. Not shown to have lipid transfer activity.", "AFDB_id": "AF-P25307-F1-model_v4" }, { "swissprot_id": "Q10323", "sequence": "MNKILFYFFFFLTLILSATVYLFGGPMMLFFINYKTDLLKVDDVYNHEIYSNQSAAIPKIIHQTWKTNEIPEKWVGAQKSCIDLHPDYEYVLWTDESMREFIATDYPWFLTQYDSYPYNIERADVVRYFILYKYGGIYLDLDVGCNRTLDPLLHYPAWVRRTSPSGISNNVMGFAKGHPFLLQVVRNLPRFAFNYHFPYLTVMYSTGPLFLSIIWSAWRKLPDAEAWHHIWVMVPELYEKSHHAFFEIYEGSSWHDSDAGFVFYMLHHWAIFTFLGFLTFFIVVYFIFGYALKPAARVSRTGRRVFSSPFSKTSPSRWKIFHRFTSSNEKYDQTRSDSLPFMSDYDLESQTQSHSP", "function": "With imt1 and imt2, is required for the synthesis of mannosylinositol phosphoceramide (MIPC). Catalyzes the addition of mannosyl to inositol phosphoceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole.", "AFDB_id": "AF-Q10323-F1-model_v4" }, { "swissprot_id": "Q96EY8", "sequence": "MAVCGLGSRLGLGSRLGLRGCFGAARLLYPRFQSRGPQGVEDGDRPQPSSKTPRIPKIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALELVTEKGHTFAEELQKIQCTLQDVGSALATPCSSAREAHLKYTTFKAGPILELEQWIDKYTSQLPPLTAFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSDYLFTLARYAAMKEGNQEKIYMKNDPSAESEGL", "function": "Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA (Probable).", "AFDB_id": "AF-Q96EY8-F1-model_v4" }, { "swissprot_id": "Q18240", "sequence": "MSEEPAAKRMKNADEFPNLRSEVAGPVKEKLIELDAIQHQLDVMSENAAEEVLKVEQIFNQKRLPIYEKRKKLTTKIDNFWQTAFLNHHLLSTAIPEEQEDLLAALRDLEVQEFEDLRSGFKIIMTFDPNEYFTNEVITKSYHLQSESPSTEITEIEWKENKKPPFPEDGDSAHTFLEWLTYAALPDSDEIAEVIKDDLYVNPLQYYVMPDMQEVEEDDIEDFLNEERGVDENGQRIPRRNISDSLKVDQDESADGQEGEDEEEEDMGEEEEDGVEEEAEGEEEEEDGAIEEEGGDENVEAHVAVNPENTAE", "function": "Potential corepressor protein, which may affect chromatin structure and/or transcription. May participate in the transcriptional repression of the presenilin protein hop-1.", "AFDB_id": "AF-Q18240-F1-model_v4" }, { "swissprot_id": "O14114", "sequence": "MKEEASEHGGSADETQELSPVSDSSDEMPNNAKRRRRSQSMIANKRIHQAFQEDEGDEDWEEEEHKPKAKRRYNTRSNESFSEGDDEPFEVSESSALEDELSDSEDSFIRSVRSKPKYKPGTRRSTRLRNRRSQDEEESEEEHRPILRERTSRINYSVPLAFPPVDEMDGDPSSQVNQSRSRKTHSELAITKLLRQQVSSFMPYIDSSGSESESDNTRIKKSSAKTIKALTDPANSGGPPDFGRIREKSDLADSDPLGVDSSLSFESVGGLDNYINQLKEMVMLPLLYPEIFQRFNMQPPRGVLFHGPPGTGKTLMARALAAACSSENKKVSFYMRKGADCLSKWVGEAERQLRLLFEEAKSTQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMESRGQVIIIGATNRPDAVDPALRRPGRFDREFYFPLPDRDARKKIIEIHTRNWDPPVPEWLCSMLAEKSKGYGGADLRALCTEAALNSIKRTYPQLYRSTKRLQIDPKTIKVKVKDFVMSMKRMIPSSERSSISPSKPLSPELKPLLNEAFQDIEKTLQKLMPVASKLNPLEEVMYDDPKENDFEYQQRLETFETLRIYKPRFLICGRKGLGQTALGPAILQQYEGVHVQSFDMSTLLQDSTQSIETSIIHLFLEVRRHTPSIIYIPDIDNWLNVLPLTAITTFSSMLERLDFSDQILFLALSSSPLSELHPQLREWFSSKQSVYSLQYPTRDSIIAFFQPILELIKASPTELPGGIPRKRRVLPELPLAPDPPPFTSQKITLKQTKQADMRLLNKLKIKLNALLGSLRARYRKFKKPLIDFNDIYCVDPETGHSYRSREECHYEFVDDVVKQIGSDQKFSMMSLEEIEKRTWDNCYCTPKQFVHDIKLILRDALQLEDSETIKRAQEMYANVLLGVEDMEDDQFSQRCERMALREAERRKLRHGKLQKHLDETKADMQFTSEKPSVDESITEVDDAIKDGPPVLAETLTNSLMEDVGPENVDMDIEDNEIFTNQSTMSVPSMLVENEESPKPDEYIDQKDKVQSPLLNGKSPVGVPSEAALRVSTDVSTNISSNGRADIPVDTLITSPADVPNNAPTDAHNITSADGHIENIEQEVVFPDLVFDEDRLTPLKQLLIDSTTGFTVDQLLHLHSFLYQIIWNTKSEWNRNSVVDECERAVKEFMINALQ", "function": "ATPase histone chaperone which facilitates loading of histone H3-H4 onto DNA in an ATP-dependent manner. Plays a genome-wide role in nucleosome organization and establishment of chromatin. Also plays a role in heterochromatin assembly by stabilizing recruitment of the histone methyltransferase clr4 to methylated histone H3, to promote the transition from H3K9me2 to H3K9me3.", "AFDB_id": "AF-O14114-F1-model_v4" }, { "swissprot_id": "A4VND9", "sequence": "MKSIHWPLAGVAALLLSMQAQAADGQKIYTQGGANPAAMACATCHGADAMGMAAAGFPRLAGIDAGYSRKQLDDFRSGARSNPIMQPIAAALSDEEMDAVAATLEAMPAPDFAAIGRSEAAEGVGARLALRGAWERNIPECVACHGPAGMGVGASFPPLAGQSAQYLGAQLNAWRQGTRKNDPNDLMGHIARAMSDDEVQAVAEYFANVGQKETGQ", "function": "Acts as an electron acceptor for the thiosulfate dehydrogenase TsdA.", "AFDB_id": "AF-A4VND9-F1-model_v4" }, { "swissprot_id": "A6QAM3", "sequence": "MEGVFTYLGGILGEDSHSAVLIAHLLLVAVIVIMIAKMATKSFRAVPNGTQNVMEAYLGGVVAMGKDVIGEELARKYLPLVAAVGLFIFVSNVIGIIPGFESPTSNINVTLPLALMVFVYYNYEGIKKHGVVHYFAHFAGPVKLLAPLMFPIEIVSHLSRIISLSFRLFGNIKGDDLFLWVLLMLVPFVAPLPAYLLLTFSALLQTFVFMILIYVYLAGAVAIDEEHEKAPAPAIDTMGAV", "function": "Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.", "AFDB_id": "AF-A6QAM3-F1-model_v4" }, { "swissprot_id": "B0Y566", "sequence": "MYTALGLAVFTALFHYTIVLAINHYRTREILSQLVKAHNCCPPKTERPWDILGLVKIYSSTKHLLNETALSNVSALFKCYGDTYASRILTQRVYFTCDPRNIRHVLINRFSDFDASDVRAHLFAPITPHGIFAVDGAEWKEARSLYADIFSATRKIFDLQLQEDGFQGLIKQIPRGQAMDLAPLFLKLVLDVNSAFAMGTGLDTLKQDQSLEKKEVAEALMYAKKIMARDGFLGPLHYLLSRKDFYAACETVKAYVEKVVRKEMTAREYQKQSNAATVDDERQKRTQSLLSRILDNTNDVHAVRDAVVTILIAGTDSVASMLSTTFYLLARHERVYAKLRQEILDTIGTEPPTYDNIRKATYLRYVFNEAMRVYPPVPFNARTANRDTYLPAGGGPDGQSGVLIRKGQRVIFASWGSHRSTRSFGADALEFRPERWEGLKSESLGYIPFSAGPRVCLGQQYALLEASYATIRIIQTFERLENRDVRPWTEKIGLNLSNKNGVLVELVH", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis fumihopaside A, a hopane-type glucoside that enhances the thermotolerance and UV resistance of N.fumigata. The first step of fumihopaside A biosynthesis is performed by the squalene hopane cyclase afumA that catalyzes the cyclization of 3S-oxidosqualene into the hopene 21-beta-H-hopane-3-beta,22-diol. The cytochrome P450 monooxygenase afumB is responsible for both hydroxylation at C-24 and oxidations at C-30 of the afumA product. The glycosyltransferase afumC then catalyzes the glycosylation at C-24, using UDP-D-glucose as a donor, to produce fumihopaside A. AfumC is also able to accept UDP-D-galactose and UDP-D-glucuronic acid as donors to yield minor derivatives. Fumihopaside B, another minor derivative produced, is different from fumihopaside A due to the presence of a double bond between C-22 and C-29.", "AFDB_id": "AF-B0Y566-F1-model_v4" }, { "swissprot_id": "P44979", "sequence": "MENQNYSVAVIGLGSMGMGAAVSCINAGLTTYGIDLNPVALEKLKAAGAKAVAANGYDFAHELDAVVILVVNAAQANAVLFGENGIAKKLKAGTAVMVSSTMAAQDAQIISQKLTELGLIMLDAPVSGGAAKALKGEMTVMASGSKQAFELLQPVLDATAAKVYNIGEEIGLGATVKIVHQLLAGVHIAAGAEAMALASKAGIPLDVMYDVVTNAAGNSWMFENRMKHVVEGDYTPLSMVDIFVKDLGLVNDTAKSLHFPLHLASTAYSMFTEASNAGYGKEDDSAVIKIFSGVSLPKKGA", "function": "Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).", "AFDB_id": "AF-P44979-F1-model_v4" }, { "swissprot_id": "Q9X1L0", "sequence": "MCYSANGNTFLIVDNTQKRIPEEKKPDFVRENVGDLDGVIFVELVDGKYFMDYYNRDGSMAAFCGNGARAFSQYLIDRGWIKEKEFTFLSRAGEIKVIVDDSIWVRMPGVSEKKEMKVDGYEGYFVVVGVPHFVMEVKGIDELDVEKLGRDLRYKTGANVDFYEVLPDRLKVRTYERGVERETKACGTGVTSVFVVYRDKTGAKEVKIQVPGGTLFLKEENGEIFLRGDVKRCSEE", "function": "Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan. Also catalyzes the racemization of certain amino acids, including Lys, with low efficiency.", "AFDB_id": "AF-Q9X1L0-F1-model_v4" }, { "swissprot_id": "Q87FA5", "sequence": "MKKTVFNPALNRAAAILIGTLVGISGVVHASVDISSSPLHGGKDVPGNLAILASVEFPTLISVANLADTYTPGVRYVGYFDSNKCYKYHYSSRELDRYFYPVASPRPQANYGCNTTGGVWAGNFLNWAATQTIDPFRSALTGGYRVRDTVSETILEKAVMDRDSQENFPRRNVAGRNVLATLVPTQWNNFRIRIDGLGNRMRFTQFSSLWTDPLNTEGQPYDSSRHPLNRNDRGVYEVSVRVKVCDPSAGLESNCVAYPRGSYKPEGLIQEYSKRIRYSVFGYKNDHSYLIDGGVLRARQKFVGPQTHYPEQGKKTNSHAEWDPQTGILYDNPDPEDAAATTRRVGRTIANSGVINYLNKSGQMDTGRISKIYDPVSELYYTAYRYFKRLGNVPEYSVLTGSVNEKYQQADAFPVITDWDDPIRYACQSNVVLGIGDTHTNQDKNLPGNTNTMEEPSKPQTVRNDRSIDVVKRMAQIFRMEGMRQQDAMTSAVAPKFNFHRYNSAYIAALAYDAHTKDMRPDLEGDQLLTTHWVDVVEAGDYKIPISTNQYWLAAKYGGFQVPAGYDPDKTVNPLSEATWWTNGEYVNNDLKANAKRADNFYVAADAEKMVASLKHAFSRIVAEIKGAGTGLSSNSARLETGAVTYQAQFFSGTWRGDLIAYHVDKVTGALTPFWNANFPAWEQRVIKFANATTLQDFTKKNLGQTALASASAQQINYLRGDRSQEGNVPGKLRIRSGIMGDIVNSQPLYVGAPNGRLYTTANFTGASAYAAFAAQQANRVPVVYVGANDGMLHAFDANTGKEIFAFVPRAAMPKLLEYTDQNYGHQYYVDGELTAADIYDTKLGWRSVLVGTLGRGGKGLFALDVTDPSNIRLLWDKTSADIGGLGNTLSKPMIAQTSDGTWSVLLGNGPNSTADNAQLIVMNLLTGHAAQVPVSKTSNNGLSGVFPWSSQSNGITDRVYAGDLLGTLWRFTFSDNAWKVAPLFTATYQGKAQPISATPLGAIERSTGRMWIFFGTGRALSSHDMDNKEVQSWYGLIDQGTTIPGRTRLSQVQIVDEGVVNGYAVRTVSDPKNIGTDGWYMDLISPKSGKQGERMIVSNMFRGAALIGTTRIPDNSDICKLSGSGFVMAINPFTGGRLGQWFFDLNTGGGSGGALNGNPVSGVGVSSAPNSPVFTGNIMQIGADDGTVTSLKTPSSGGLNINRVSWREILRTE", "function": "One of the three PilY1 homologs of X.fastidiosa, which are involved in bacterial twitching motility as component of the filamentous type IV pili (T4P).", "AFDB_id": "AF-Q87FA5-F1-model_v4" }, { "swissprot_id": "Q9USU8", "sequence": "MSSEQQNEADSKPAVIPQCFKIENQYETFSRLSETSTPGVVPSVSTLWRLLFELQKMIECEPSCVEYFRQRKEELESHVDSEIETSKDESSVNKVEEKVEEFKEDNVEQEIKQKRSLSESPQESMLEKVSKKPKVSEAHNEEISPENVETIENELDLPVKGKDEQTTGLVYKNANDLLTGSLLSFIVDDSFSYEQKKKLLCVDSFPTSDVRSLVAGTPATDDFSHNKPNNQISISTFYSSLDPYFRAFNDDDIAFLKKGFDVSSSYNIPPLGERYYDLTPEDEMTNLCANSIYQNLQTSAQGSLEAFNEADTVSEEVRCGPLTERLMASLIPCYTQNDEEQKPSIAVGEFAETDSGSEKSKIGTSIDGIESGNNEYTEQPDIQESSLSICEDRLRYTLKQLGILYDGDVDWSKRQDDEISATLRSLNARLKVVSDENEKMRNALLQMLPEEMAFQEFQNVMDDLDKQIEQAYVKRNRSLKVKKKRIVTDKIGSSATSGSFPVIKSLMDKRSMWLEKLQPLFQDKLTQHLGSPTSIFNDLSDHTTSNYSTSV", "function": "Transcription regulator. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of a subset of genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B.", "AFDB_id": "AF-Q9USU8-F1-model_v4" }, { "swissprot_id": "Q8S7W9", "sequence": "MASNGMASSPSSFFPPNFLLHMAQQQAAPPHDPQEHHHHHHHGHHGHHHEQQQQQQHHHHLGPPPPPPPHPHNPFLPSSAQCPSLQEFRGMAPMLGKRPMSYGDGGGGGDEVNGGGEDELSDDGSQAGEKKRRLNVEQVRTLEKNFELGNKLEPERKMQLARALGLQPRQVAIWFQNRRARWKTKQLEKDYDALKRQLDAVKAENDALLNHNKKLQAEIVALKGREAASELINLNKETEASCSNRSENSSEINLDISRTPPPDAAALDTAPTAHHHHHGGGGGGGGGGGMIPFYTSIARPASGGGVDIDQLLHSSSGGAGGPKMEHHGGGGNVQAASVDTASFGNLLCGVDEPPPFWPWPDHQHFH", "function": "Probable transcription factor.", "AFDB_id": "AF-Q8S7W9-F1-model_v4" }, { "swissprot_id": "Q9X8Z8", "sequence": "MNTSLTNAARLFTAGLRALLVLTVVTGIVYPLVVTGVAQGLFPGKANGSEIKADGKVVGSSLIGQSYNLPLKEGRETPEPDLRWFQGRPANGLGTNTVNTRYELILSGATNRSADDPELLQWVQDAKAAVVRDNSVPGHPVRPEDVPADAVTSSGSGLDPDISPRYADLQVHRVAAKNGLPAERVQELVDEHTTPRTLGFIGEPRVNVLELNIALVELVAPGAGH", "function": "Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.", "AFDB_id": "AF-Q9X8Z8-F1-model_v4" }, { "swissprot_id": "Q9LQL2", "sequence": "MSCLEIYNKDTMKKKEGEEETRDGTVDYYGRPSIRSNSGQWVAGIVILLNQGLATLAFFGVGVNLVLFLTRVLQQNNADAANNVSKWTGTVYIFSLVGAFLSDSYWGRYKTCAIFQVIFVIGLSSLSLSSYMFLIRPRGCGDEVTPCGSHSMMEITMFYFSIYLIALGYGGYQPNIATLGADQFDEEHPKEGYSKIAFFSYFYLALNLGSLFSNTILGYFEDEGMWALGFWASTGSAIIGLILFLVGTPRYRYFKPTGNPLSRFCQVLVAATKKSSVEAPLRGREEMYDGDSEGKNASVNTGRRIVHTDEFKFLDKAAYITARDLDDKKQDSVNPWRLCPVTQVEEVKCILRLMPIWLCTIIYSVVFTQMASLFVEQGAAMNTSVSDFKIPPASMSSFDILSVALFIFLYRRVLEPVANRFKKNGSKGITELHRMGIGLVIAVIAMIAAGIVECYRLKYADKSCTHCDGSSSLSIFWQAPQYSLIGASEVFMYVGQLEFFNAQTPDGLKSFGSALCMMSMSMGNFVSSLLVTMVVKISTEDHMPGWIPRNLNKGHLDRFYFLLAALTSIDLVVYIACAKWYKPIQLEGKDEMQDMSDDDYDTESEEEREKDSKV", "function": "Low-affinity proton-dependent bidirectional nitrate transporter. Involved in nitrate loading into xylem and not in nitrate uptake. Not involved in histidine or dipeptides transport.", "AFDB_id": "AF-Q9LQL2-F1-model_v4" }, { "swissprot_id": "O25249", "sequence": "MLRLLIGLLLMSFISLQSASWQEPLRVSIEFVDLPKKIIRFPAHDLQVGEFGFVVTKLSDYEIVNSEVVIIAVENGVATAKFRAFESMKQRHLPTPRMVARKGDLVYFRQFNNQAFLIAPNDELYEQIRATNTDINFISSDLLVTFLNGFDPKIANLRKACNVYSVGVIYIVTTNTLNILSCESFEILEKRELDTSGVTKTSTPFFSRVEGIDAGTLGKLFSGSQSKNYFAYYDALVKKEKRKEVRIKKREEKIDSREIKREIKQEAIKEPKKANQGTQNAPTLEEKNYQKAERKLDAKEERRYLRDERKKAKATKKAMEFEEREKEHDERDEQETEGRRKALEMDKGDKKEERVKPKENEREIKQEAIKEPSDGNNATQQGEKQNAPKENNAQKEENKPNSKEEKRRLKEEKKKAKAEQRAREFEQRAREHQERDEKELEERRKALEAGKK", "function": "Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components.", "AFDB_id": "AF-O25249-F1-model_v4" }, { "swissprot_id": "Q6WFW1", "sequence": "MAKEHIVLFPFMSQGHIIPFLSLAKLISERHPTYTITLLNTPLNILNLQSTLPPNSNIHLKSLPYRSSDFGLPPDRENTDSLPFPLVLSFYQSGESLATHFTHFVSDLTRQNHDTPPLLIVADVFFGWTAEIAKRLNTHVSFSTCGAYGTAAYFSVWLHLPHAETDLPDFTAPGFPETFKLQRNQLSTYLKKADGSDRWSKFFQRQISLSLTSDAMICNTVEEMEAEGLRLLRKNTGLRVWSIGPLLPSLPPNSSLGRSGRKSGMEVSYIMKWLDSHPPGSVVYVSFGSIHDTAAQMTSLAVGLAVELATRSCGHSGRRFGGNRNRNSNPNGVPDEFEARMRGSGRGILIHGWAPQLEILEHESTGAFVSHCGWNSTLESLSRGVCMIGWPLAAEQFYNSKMVEEDWEWGGTCEGSGGGVRSEEVERLVRLVTEDEKGSDEENEQYDEMIGGYEEKGGEGSLSGQLIKFIGMESQ", "function": "Crocetin glucosyltransferase involved in the synthesis of crocin, one of the apocarotenoids responsible for the color and bitter taste of saffron.", "AFDB_id": "AF-Q6WFW1-F1-model_v4" }, { "swissprot_id": "O94710", "sequence": "MLCLVYNSILCKQRRISLKVLQQFRCWNISKTFLSYRTLTALAIETSCDDTSVSVVRTSDSSSHCQNEIICLNTHRTISKYEAYGGIHPTIVIHEHQKNLAKVIQRTISDAARSGITDFDLIAVTRGPGMIGPLAVGLNTAKGLAVGLQKPLLAVHHMQAHALAVQLEKSIDFPYLNILVSGGHTMLVYSNSLLNHEIIVTTSDIAVGDYLDKCAKYLGIPWDNEMPAAALEQFASPEINSTSYSLKPPIPLNTREKVHSASFSFSGLESYACRIIRKTPLNLSEKKFFAYQLQYAAFQHICQKTLLALKRLDLSKVKYLVCSGGVARNELLKKMLNDTLMVLQFEHQPTDIKLVYPSPDICSDNAAMIGYTAIQMFKAGYTSSFDVEPIRKWPINQILTVEGWLTKKNKKV", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.", "AFDB_id": "AF-O94710-F1-model_v4" }, { "swissprot_id": "P08472", "sequence": "MQFGVPLLVLCLALGSTEATISLKLVSRLYLPFDKLPVGGGAGGAGGAGGAGGGGGGGGGAGGRGGGGGGRGQTGGMYALNNGVAFKSAYDMDKQLAYVGGGQFVQIVDFSDVVQPKVVKQIATEGPVADIAECGDLVAFTQPGKPHFTDVGSLKIYEKYNPATMMMKELCSVEVGSQPIAVRFAQGCSLIIVANEGVMGENNYTKKYVNPEGTITTVRLAGSVSNGPSQQIVNTTFGAGGPMMTTPMAGFPRGTTWSPNAGAGGQGGQGQYPGQGGQGGQGGQGGQGQYPGQGGQGGQGGQGGQGGQGGYPGQGGQGGPGYYPGQGGQGGQGGQGGWGQGGGQGGQGGGNNPQYPMIPTTPLPGTICNGTSTMSYVVSQINFHKFNAPAEVQRLKALHVRQPYTGQLGDPGPHTFSRGLEPRHITLDQQEQIAYISLQENNAIAVVDLNNNTVIDILPMGVKNWKGLKIDASSADRGILFQTYDQLNSFPMPDAIETYYDAMGDLYVVTANEGAKPMMAQCSLEVCPGGPGEFEEVEIGEEFIVEELLPQPVIDSPLGQAMAEETQLGSSLFSMVDGINPAEPEFFNEVFMFGGRGISAYKVDPITMNMTLAWDSGDVIEKEIAKFFPKIFNGAAFSRPPQRVKPFMTKDSRSSGRGPECESLAVGDVQGRKLIFVGIDGVSALAIFSVAPGNSTPVYESLFKDGHIDASYNALYKNRKTGRVSGTVSMYEVIDVPYWMLLKTLGTNIEGSSAISMTSSAFSIFFAFLSGMFAIFMKM", "function": "Not known. Could be involved in mesenchyme cell migration, adhesion, fusion, or spicule formation.", "AFDB_id": "AF-P08472-F1-model_v4" }, { "swissprot_id": "Q9UTH1", "sequence": "MARIKKIFTQEELKQIPCPYDHKHTIVRHRLEYHLKRCNARPVERTDPYYKKDINISTSTDASESSSFEIVDLSKEELSKWICLFNRISDSLPTPQKKVLFHPAMNARLEEGTKKKHAIQQASLLGHMEKLHYFDNQGSIYYEFGAGRAELSRYVQHCSQQENVYILIDRDSNRTKHDSRILKDSIKNNWPEPKIIRCKIDIKDLKLDFFASEFRNSGKPVFAYSKHLCGAATDLTLNCLKSSPPNALVIALCCHHHCRWRTLSTFAREQLSHWGISNPQEFQILRQMTGWAVNSLREHMHASGGADSHISGLSHEERVKIGLKCKHIINYMRKLECEKMGYESSLVYYVGEETTLENVALIAYKRIN", "function": "tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).", "AFDB_id": "AF-Q9UTH1-F1-model_v4" }, { "swissprot_id": "Q759T1", "sequence": "MNSFRESDEEDNNPFSGTNHLYASGIGAVPEGDDDFLSAEVDTADETVQETREQMMSRLFGECEGPRESSAGGWTSGSMGSIGAPDGHSDEVTEFGIDTVLVEGEVRTPGRARVPASYPDAEGSLGALRIVDAGQYKDTFGNYAIGYTIAYEGRQVTRRYSEFDSLRQALARLLPTVIIPPIPSKHPLIRYFLNPLNAENDIRIIEKRRRLLSRFLNNCHDITDIREHTVFQKFLNPEYIWSEVLLTPPVSILPTNNLLAPPLNPTKPSPLHLLLPTPPRRTTSYGSPKTNNPEYDIRFTELESLLLRYHKCLQPVLASSRQKKIHFKQLASSLADLGAYYNAFSLEDNVINLPHQMDQIRDLSRAIEKIGQAVDVNYVSSELLVENIMILLEEPIGEMLQFVQEGREVLRFRMQKQQQFHIIDTTIKKRRGRIEELRNFQAQLARLEAALKQNAEESPTIARAVQRLDAQHLHKQRKSPSGELQWTGLFKSRSGSVRTHDSLTTRPVTGDVDVDLLSDEERAREIARLEGDLEKLNECYKLIQRDMLQVNESMARSFDWFIMYLHDTWALVLRNYTRTLLNWLKDCLTAWKNARVTIDTIAV", "function": "May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.", "AFDB_id": "AF-Q759T1-F1-model_v4" }, { "swissprot_id": "Q08879", "sequence": "MERPVPSRLVPLPLLLLSSLSLLAARANADISMEACCTDGNQMANQHRDCSLPYTSESKECRMVQEQCCHNQLEELHCATGINLASEPEGCASLHSYNSSLETIFIKRCCHCCMLGKASLARDQTCEPIVMISYQCGLVFRACCVKARENSDFVQGNGADLQDPAKIPDEEDQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGFYFDGISRTCVDINECQRYPGRLCGHKCENTPGSFHCSCSAGFRLSVDGRSCEDVNECLNSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTFRQEKTDTVRCIKSCRPNDEACVRDPVHTVSHTVISLPTFREFTRPEEIIFLRAVTPLYPANQADIIFDITEGNLRDSFDIIKRYEDGMTVGVVRQVRPIVGPFYAVLKLEMNYVLGGVVSHRNVVNVHIFVSEYWF", "function": "Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.", "AFDB_id": "AF-Q08879-F1-model_v4" }, { "swissprot_id": "I6Y778", "sequence": "MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWADSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGATIAEVFARDGAHVVAIDVESAAENLAETASKVGGTALWLDVTADDAVDKISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA", "function": "Catalyzes the NADH-dependent reduction of beta-ketoacyl derivatives. Can accept the beta-oxo fatty acyl group covalently linked with CoA or ACP for catalysis. Highly specific for NADH. Could be involved in fatty acid biosynthesis (Probable).", "AFDB_id": "AF-I6Y778-F1-model_v4" }, { "swissprot_id": "Q93ZJ3", "sequence": "MATSAVLSGARSMLRAASSRSAAASTGRFASQAKSAPPLFRATARRSPLLSPLRNPVELSFCVESLLPYHSATASALMTSKLSISGQTYGWLSDACNDDV", "function": "Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus.", "AFDB_id": "AF-Q93ZJ3-F1-model_v4" }, { "swissprot_id": "Q23232", "sequence": "MSFITAFRERVFIASGDLIRTFRISEETELKNFISWSKINPERIQKPSFDIEKELKAVEKRVILCLAHSNVLTTHGRRLVAVGTNEKQIHVFEYFVNDKGDIVTAEHIVTSVVPKAPTAIVFDKEDAYVVVGDRAGDVHRFSVLNGSAIEMAGAISMILDVAFSPDGKRLLMADRDEKVRALRYPATSVIDSFFLGHTEYVKTLAVQDNDSLWSSGGDKNLYNWSIAKCSAPRRTLDLSQFDAPIRKISINLQHKKIAVIFEKIETVVIVDLNQESLQTTSVSIVGESQCLDIASTKDYFAVLGRSTVHLIDLNNMEQKFVPIDEELTITLTSTNDAIDNLFKNVTHNNQQEYEKRKADKFEQIEKKKRRLNEDINGDDGEGPGPSNS", "function": "Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.", "AFDB_id": "AF-Q23232-F1-model_v4" }, { "swissprot_id": "Q73IR3", "sequence": "MNFRQLIFKILYNENNMKKFLLKPKKSLGQNFILSSEITKKIVALAGSLENFNVIEIGPGYGALTREILVHNPKSLLSIEKDRDLVKHHDQLLNEHQGKYRIIEADALHIIEEELIERPVKVIANLPYNISVALFLKWLDSIKFFTSLTLMFQKEVADRITARPNSKDYGPLSVLSQLLCDIKKEFDIEPKEFFPRPKIHSSVITVNPLPTPKFVVNLETLIKLIRAVFAQRRKMLRNSLQNITNHAETVLENAKLSGNERPENLTIEQFCLLANNVECLLCNKMY", "function": "Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.", "AFDB_id": "AF-Q73IR3-F1-model_v4" }, { "swissprot_id": "Q9L4Q7", "sequence": "MDMDAKQAVIAKLDELKINYTLIEHDPVYTIEEMEKIDIENVDYIVKNLFLRDAKGRQHYLVVADKDQKIDLKTLQDKIGSTKLSFASEDRLQKYLKLTKGAVSPFGVLNDETAEVEVVFDKNLVGRSCVAVHPNDNSATVVLSYEDLEKIVKANGNTFKAIEL", "function": "Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro). Has weak activity on correctly charged tRNA(Ala), tRNA(Gly) as well as tRNA(Cys), tRNA(Met), tRNA(Pro), tRNA(Ser) and tRNA(Leu).", "AFDB_id": "AF-Q9L4Q7-F1-model_v4" }, { "swissprot_id": "Q8L7W7", "sequence": "MAWLSRVRGVSPVTRLAAIRRSFGSAAALEFDYDSDDEYLYGDDRRLAEPRLGLDGSGPDRGVQWVLMGAPGAWRHVFAERLSKLLEVPHISMGSLVRQELNPRSSLYKEIASAVNERKLVPKSVVFALLSKRLEEGYARGETGFILHGIPRTRFQAETLDQIAQIDLVVNLKCSEDHLVNRNETALPQQEFLGSMLHSPVAINARRESVGVYAQEVEEYYRKQRKLLDFHVGGATSADTWQGLLAALHLKQVNLTTSQKLTL", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.", "AFDB_id": "AF-Q8L7W7-F1-model_v4" }, { "swissprot_id": "P0CV35", "sequence": "MAQLHRWDFWCFSTKPLGYLDVVQAIEAEVYDAWRQLRQSANPSKAWHQWKSETRKLFQDLDKKLRGQQEAVVHVAHATFTVAEMQYRQCGGEASHIVF", "function": "Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins.", "AFDB_id": "AF-P0CV35-F1-model_v4" }, { "swissprot_id": "Q8XWR3", "sequence": "MLIHPQFDPIALHLGPLAIRWYGLMYLAAFIMFLWFGRLRTRQPHIAAQGWSGRDLDDMLFYGVLGVILGGRLGYVLFYKPDWYLAHPLDIFKVWEGGMAFHGGFLGVVLAMMLYARMRRRPWMQVTDFIAPMVPCGLAAGRLGNFINGELWGRVSSPDLPWAMLFPQAQGEDRAWLAAHAQQAVTSGVQAVFDQYHMLPRHPSQIYQFLGEGVLFFILLWLYARKPRPMGAVSGMFLVGYGVFRFAAEFAREPDNFLGLLALSLSMGQWLSLPMILAGVAMLAWAYRRAGRNGNDAQAGAHA", "function": "Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.", "AFDB_id": "AF-Q8XWR3-F1-model_v4" }, { "swissprot_id": "O66961", "sequence": "MAEEKKEVQKTPEQKMDELNRQLRGYMANIEALRAEISVINQSITDLRTAEATLRSLKELGKGKEVLIPVGATAQIKAKSEGVDEVIMSIGTGISAVMSYDEAVDRIRKEIAALEALRRALEEAIADLYNKIEELLEEVRKVGQEEAKK", "function": "Molecular chaperone capable of stabilizing a range of proteins.", "AFDB_id": "AF-O66961-F1-model_v4" }, { "swissprot_id": "P40238", "sequence": "MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP", "function": "Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.", "AFDB_id": "AF-P40238-F1-model_v4" }, { "swissprot_id": "P38996", "sequence": "MSDENHNSDVQDIPSPELSVDSNSNENELMNNSSADDGIEFDAPEEEREAEREEENEEQHELEDVNDEEEEDKEEKGEENGEVINTEEEEEEEHQQKGGNDDDDDDNEEEEEEEEDDDDDDDDDDDDEEEEEEEEEEGNDNSSVGSDSAAEDGEDEEDKKDKTKDKEVELRRETLEKEQKDVDEAIKKITREENDNTHFPTNMENVNYDLLQKQVKYIMDSNMLNLPQFQHLPQEEKMSAILAMLNSNSDTALSVPPHDSTISTTASASATSGARSNDQRKPPLSDAQRRMRFPRADLSKPITEEEHDRYAAYLHGENKITEMHNIPPKSRLFIGNLPLKNVSKEDLFRIFSPYGHIMQINIKNAFGFIQFDNPQSVRDAIECESQEMNFGKKLILEVSSSNARPQFDHGDHGTNSSSTFISSAKRPFQTESGDMYNDDNGAGYKKSRRHTVSCNIFVKRTADRTYAIEVFNRFRDGTGLETDMIFLKPRMELGKLINDAAYNGVWGVVLVNKTHNVDVQTFYKGSQGETKFDEYISISADDAVAIFNNIKNNRNNSRPTDYRAMSHQQNIYGAPPLPVPNGPAVGPPPQTNYYQGYSMPPPQQQQQQPYGNYGMPPPSHDQGYGSQPPIPMNQSYGRYQTSIPPPPPQQQIPQGYGRYQAGPPPQPPSQTPMDQQQLLSAIQNLPPNVVSNLLSMAQQQQQQPHAQQQLVGLIQSMQGQAPQQQQQQLGGYSSMNSSSPPPMSTNYNGQNISAKPSAPPMSHQPPPPQQQQQQQQQQQQQQQQPAGNNVQSLLDSLAKLQK", "function": "May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing. Binds to poly(A)+ RNA. Appears to act in the maintenance of CLN3 mRNA levels.", "AFDB_id": "AF-P38996-F1-model_v4" }, { "swissprot_id": "Q9HHT0", "sequence": "MTVTDHREAMIEARAAVTDVREAMDAYAEEFAADVNSIRTDSRHRENIRDMRAAVDAYCESFATAVSTHHDETAALRADLEATAAAFDAYTTAFAADAAAMHDVSALHRDIEALREEFRAVTTDFEDYTTDEFAPAVGALHADAAETAASFTAKQEGFEAYRHDVHESAVPALTADIAATRADFDDTAASFAAYARAFYGHTDDATAQTDADDTTAQTDVLSGQATVTRAQPEEDDTPEDMVQCRVCEEYYQAITEPHLQTHEMTIDGYRDEYGEDVPLRPDDHA", "function": "May confer stability to the gas vesicle membranes. Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.", "AFDB_id": "AF-Q9HHT0-F1-model_v4" }, { "swissprot_id": "P31759", "sequence": "MLTASQKVLQQLAALLLERAGLKITPDGFHSLRLALSARMPVLGLEEPEHYIQRLTGAGGEEELRSLLPLVTVGHTEFFRDAKQFRALEKSVLPDLVSRSRREMRKVSIWSAGCATGEEPYSLAMVLAELGALSLEVDLWATDLNLAAVEAAKQGRFTSRRAISINQARLTRFFKPVEEGYEALPALREYIRFDGQNLAVPVFDKVALSSLDLILCRNVIIYFDLPTIRGLMDRFLAALRPGGLLFLGYSESLFKVYDRFEMIEVDGAFVYRRPLNDKSMRAPPLRITPYPGEPDVAARRPVPADAFTADLRKRMLPEDVPLTTRLPAVSASSVAAPGSPSVTLPALGASSSPRSVVPGRLPAVSPHSPLPAIAARSRVTAELPTVGSVDSARPRITTELPAVATTPRAPTVEVPAWPTLLPPAERLAMAVRKMAQGDFSAAIAGVQRLLADEPSDLDGLLTLGNLFSLTGRIPEAREAFAQAIQREPLCVEARVFGGVAALQAGELSEARSELSKALFLEPTLAIGHYLLAQVHERTQDHEAARRSYRNAIAQLRFPQRPLAGHYPEMPDSADAISRAARYALAALEEQPLR", "function": "This methyltransferase is one of the proteins required for the normal aggregation of M.xanthus cells during fruiting body formation. It is also a component of a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. It may methylate FrzCD to form gamma-glutamyl methyl ester residues.", "AFDB_id": "AF-P31759-F1-model_v4" }, { "swissprot_id": "Q08471", "sequence": "MDKSMIKKRGRPPITKDYPNPLQSPMAHSSMQVQKQGPHSFAKPLMKVGQSSPSPNKRRLSIDHHHNLAATTRKGRYRGVLLSTPTKKSSTNGSTPISTPSSNDSYNNTVFSETRKTFLQSSPPIMTSSPAFQKKNDYMFPSQEQFKLSLTITESGKAVIAGSLPFSPSSKSSHLMNNNNKKIMQNEKIHKGSKKNAPKFEKRRILSLLKQMKNEKYCDTDTLPEAPPAKPSRSDIIDTELPTIIETSASPIGSARNNNILLSQPPQSPPSSAQLKPPSTPKSSLQFRMGFTPNVALNSVSLSDTISKSTNAVGASNNNNQNGNSISNIADANTLLTLTNSPGVFLSPRNKMLPKSTTASNEQQQEFVFKFSSGDPLLLTDDADGNWPEMLFNVSNTPRRQKCFNTPPSWINFGSPGLFSPPRSSNVMVNGTTVATASDSGNVHRQLQAQLEAQVQVQSQSNSPTQRQQQQRQFQIPPPHINMNSSPPQINIASPPHQSMSRVSSIYFNKEKTTTGVANMLGNTKSENLQPPANLFTAAHGPSTPRNQEFQLPTLIECTPLIQQTMNGSLGTKYIPGTSISNSATPNLHGFPVGTGKAPSSFDDSLKQNPYSNKQDDARTALKRLIDDQ", "function": "Activator of G1-specific transcription factors, MBF and SBF. Promotes both the timing of G1-specific gene transcription and cell cycle initiation. Associates with SBF- and MBF-regulated target promoters and this binding is maximal during the G1 phase, prior to maximum budding. Affects cell cycle initiation by advancing the timing of transcription of G1-specific genes. Overexpression advances the timing of SBF-dependent transcription and budding. Depletion delays both indicators of cell cycle initiation.", "AFDB_id": "AF-Q08471-F1-model_v4" }, { "swissprot_id": "Q9NXJ0", "sequence": "MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPNMYESNPVTPASSSAPPRCNNYSANAPK", "function": "May be involved in signal transduction as a component of a multimeric receptor complex.", "AFDB_id": "AF-Q9NXJ0-F1-model_v4" }, { "swissprot_id": "O70305", "sequence": "MRSSTAAVQRPAAGDPEPRRPAGWAARRSLPRTARRGGRGGAVAYPSAGPPPRGPGAPPRGPRSPPCASDCFGSNGHGASRPGSRRLLGVCGPPRPFVVVLLALAPAATPARACPPGVRASPPRSGVSSSARPAPGCPRPACEPVYGPLTMSLKPQPQPPAPATGRKPGGGLLSSPGAAPASAAVTSASVVPAPAAPVASSSAAAGGGRPGLGRGRNSSKGLPQPTISFDGIYANVRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESVLFKCSDFVVVQFKDTDSSYARRDAFTDSALSAKVNGEHKEKDLEPWDAGELTASEELELENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNCSDREGHGPNTRDNKYIPPGQRNREVLSWGSGRQSSPRMGQPGPGSMPSRAASHTSDFNPNAGSDQRVVNGGVPWPSPCPSHSSRPPSRYQSGPNSLPPRAATHTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSMSSGLEFVSHNPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSPSGPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRLQDQRQNSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHKRGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPAYTTPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGPKAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL", "function": "Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.", "AFDB_id": "AF-O70305-F1-model_v4" }, { "swissprot_id": "Q2NJ78", "sequence": "MSILLEKIKTLPPNPGCYLFKNTKDTIIYVGKAKNLKKRVQSYFTKRNNLKTAMLIEETQDFFYIITNNEQEALILEANLIKTHTPKYNFKLLDDKTYPYIEITKEKHPQLKISRFKQIPPGKIIFGPYPNLKSTKETLKLLHLLYPLRRCQLASKKPCLHFHINQCLGACAGKTINYKPNIDAITKFLKGNIKDILKKLHHLMQKASEKMFYEKAQEYRDIIDSIKQTTKKQLISNQKLKNCDIFAYAFNQDQIAIQILKIRQGNIVDSYRSVFSYVGFVCENILTYLNCYYQKNIKPDIIITGKNQDENILQQTITNQTLLEQILQTKVNIYHKGDKKKLFLLALKNAQNDLSHNNLIYQSKDQKIQEALNKLAIIFNKDIKRIDVFDNSQLFGKAFVAARIVFNHFEFDKKLYRTFHIKGELPNEYQAFEETLTRCYNKGKEAENDATDLILVDGSLVQLRQSQKTLKKLGYEIPLGALQKNNKHQLTHLVTFQEKLMLEQDPNLFHFLKSLSEEVHRFAVSFHRKTKKKLDYKTTLSNIKGVGVVRKKAILNHFESLEAIKKATLQDFQKIGINQKLFLLIKKSL", "function": "The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.", "AFDB_id": "AF-Q2NJ78-F1-model_v4" }, { "swissprot_id": "P05846", "sequence": "MSATRIQAVYRDTGVEAYRDNPFIEALPPLQESVNSAASLKSSLQLTSSDLQKSRVIRAHTICRIPDDYFQPLGTHLLLSERISVMIRGGYVGRNPKTGDLQKHLQNGYERVQTGELETFRFEEARSTAQSLLLIGCSGSGKTTSLHRILATYPQVIYHRELNVEQVVYLKIDCSHNGSLKEICLNFFRALDRALGSNYERRYGLKRHGIETMLALMSQIANAHALGLLVIDEIQHLSRSRSGGSQEMLNFFVTMVNIIGVPVMLIGTPKAREIFEADLRSARRGAGFGAIFWDPIQQTQRGKPNQEWIAFTDNLWQLQLLQRKDALLSDEVRDVWYELSQGVMDIVVKLFVLAQLRALALGNERITAGLLRQVYQDELKPVHPMLEALRSGIPERIARYSDLVVPEIDKRLIQLQLDIAAIQEQTPEEKALQELDTEDQRHLYLMLKEDYDSSLLIPTIKKAFSQNPTMTRQKLLPLVLQWLMEGETVVSELEKPSKSKKVSAIKVVKPSDWDSLPDTDLRYIYSQRQPEKTMHERLKGKGVIVDMASLFKQAG", "function": "TnsABC + TnsD promote high-frequency insertion of Tn7 into a specific target site known as att-Tn7 whereas TnsABC + TnsE promote low-frequency insertion into many different sites.", "AFDB_id": "AF-P05846-F1-model_v4" }, { "swissprot_id": "P21149", "sequence": "MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL", "function": "Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. It links pyruvate:ferredoxin oxidoreductase to hydrogenase.", "AFDB_id": "AF-P21149-F1-model_v4" }, { "swissprot_id": "O06923", "sequence": "MEQLMSLFPAISTLFTQDPVISITRIALIIFGFFLSYFGFKRTLEPLIMVPMGLGMIAINAGVLFLEAGVVGTIHLDPLVSEPSVLVNLMQVNWLQPVYNFTFSNGLIACIVFFGIGAMSDISFILIRPWASIIVALFAEMGTFATLIIGIKMGLLPNEAAAVATIGGADGPMVLFASLILAKDLFVPIAIIAYLYLSLTYAGYPYLIKLLVPKKYRGLEVEMDFPEVSQRSKFVFSVLACMLLCLLLPVASPLILSFFLGIAIKEAQIEPFQNLLETTLTYGSTLFLGLLLGALCEAKTILDPKISLIVVLGITALLISGIGGVLGGWIVYWFSKGKFNPVIGIAGVSCLPTTAKIAQKTVTEENPYAVILPLAMGAGVCGLIVSAIATGVFISTLFLLN", "function": "Beta subunit of the biotin-dependent malonate decarboxylase multienzyme complex (EC 7.2.4.4). Acts as an integral membrane-bound carboxybiotin protein decarboxylase by releasing the carboxyl group of the carboxylated biotin carrier MADF. The free energy of the decarboxylation reaction is used to pump Na(+) out of the cell.", "AFDB_id": "AF-O06923-F1-model_v4" }, { "swissprot_id": "P32953", "sequence": "MSFARVRTALRCQRAAASPAPPKVQARRFANKAAPHASASSAGSRAFHLGLAAGAALAVGGAGLYLFSRSPVLLDAQLPVKQRGRARSISAAEVAKHNSRDSMWVCIDDEVWDITNFVELHPGGAKVLEQNAGKDVTKVFKSIHPPKTLEKFLTDDNFVGRIDVDEVTKIGGGKNAEDLRIEQARKELRNVETVVCLDEFEEISQKILSEMAMAYYGTGAETEQTLRDEREAWQRVRFRPRVLRKMRHIDTNTTFLGIPTPLPIFVAPAGLARLGHPDGEQNIVRGVAKHDILQVVSSGASCSIDEIFEVKEPDQNLAWQFYVHSDKKIAEEKLKRALALGAKAIFVTVDVPVLGKRERDLKLKARSQNYEHPIAAQWKAAGSKVEETIAKRGVSDIPDTAHIDANLNWDDIAWIKERAPGVPIVIKGVGCVEDVELAKQYGADGVVLSTHGARQLDGARAPLDVLIEVRRKNPALLKEIEVYVDGQARRGTDVLKALCLGARGVGFGRGFLYAQSAYGADGVDKAIRILENEIQNAMRLLGANTLADLKPEMVECSFPERWVPE", "function": "Catalyzes the oxidation of (S)-mandelate to benzoylformate and enables utilization of mandelate as substrate for growth.", "AFDB_id": "AF-P32953-F1-model_v4" }, { "swissprot_id": "Q6AJL8", "sequence": "MFQVEMTASVREAFGKGPMRRLRQQGITPAVVYGAGKAALPLQMDAKILMTQLLEFSRVNTVVSLSVDGQDAKNVVIAEIQSDPVTDALVHVDFCEIDLDQAREFTVPVTFEGTPKGVDLGGRLESHLTSVILKAKPLDIPNEFVINIADLAIDEQLTVADVALAENVVMVTPAARVMVAVLK", "function": "This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.", "AFDB_id": "AF-Q6AJL8-F1-model_v4" }, { "swissprot_id": "Q10316", "sequence": "MTFRTLDVDSITEPVLTEQDIFPIRNETAEQVQAAVSQLIPQARSAIQTGNALQGLKTLLSYVPYGNDVQEVRTQYLNAFVDVLSNIRAADIPAFVKECSTEEIDNIVNFIYRGLANPQAYNSSVLLNWHEKVVEISGIGCIVRVLNSRPDL", "function": "Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.", "AFDB_id": "AF-Q10316-F1-model_v4" }, { "swissprot_id": "I6WHP7", "sequence": "MIHCKVQQWSPQYLRLPATGYEELTLTLNTSMLARMPEEEDQLFLVVGDSPSSTYVDWGEDCNSTRYPSYDHCTHKILYLGASAGTTRSKRLSATIGIRLSKGTGSNNVLGTPMYLLYNEMKTRIIESSK", "function": "S-adenosyl-L-methionine-dependent protein-cysteine S-methyltransferase with broad substrate specificity. Methylates trehalose-6-phosphate synthase (TPS), enhancing its enzymatic activity and promoting trehalose synthesis upon entry of cells into stationary phase.", "AFDB_id": "AF-I6WHP7-F1-model_v4" }, { "swissprot_id": "O15604", "sequence": "IFMKRSGAYHSELDKDIVQKAGNFPLMQFKTKVKVNPKFLLKGDDMDIVDEAITYYKANVFYKNLDMSICEADKLLAYLMFYLQSLLLTFTGRTKVDCDKMAFSLAIENFGLPGDGKFCLGGIADPPT", "function": "Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.", "AFDB_id": "AF-O15604-F1-model_v4" }, { "swissprot_id": "A0A1D6KUI6", "sequence": "MASLSFASSHASLFCCQQSSSAIILRPAGALLRLSRRQPSSHTISTTDQLFPRRSRMPRNVDTHAAAERNSPSTMSSLEAVDELETNGDSAVVVVREQQQQQHLLMGATDDGLPPSPYDTAWVAMVPAPGNPLVPRFPQCVDWILQNQRSDGSWGPDGGSGDHPSSPLGKDALMSTLACVLALKTWDAGEEHVRKGLSFVGNNSPSCVMTGDERDAPVGFSVIFPGMLARAIDMGLDIPMMTQANVDAFIRLRDTELNRMAATTGSKAFMSYVAEGLGDVLDWDEAAMVYQRQNGSFFNSPATTAAAAIHGNNDRALRYLDSLVNMFGSSVPTVYPRSTYSRLHMVDTLQKMGLSRSFVSEINEMLDMTYRSWLANDDEEMMLDMSTCAMAFRLLRMHGYDVSSDGLAQFSSESSFRDSVHGQANDTEALLELYKASQIQITEDELVLVDIRSWSAKLLKEQLGSDKVSRSVDAQEVQQVLKFPFYTTLDRLEHRRHIEQFKAGGFHMLKSAYRFCKEDEELVSLAVQGFHSSQALYQQELQFLTRWAKEARLHDLEFARIMPMNTFFPNAALMYAPELSEARILCTKNCMLATAVDDLFDVGGSREEMENLVRLIDMWDEHEEVGFCSERVEILFRAIYDTSKELAAKAMAVQNRSVINHVAELWADLVRAMMTEAEWSMRGHVPSSMEEYMQVAETSFALGPIVLMPLYLIGPELPEAVVRCPEYKQLFHHMNVCGRLLNDLQSYEREAKQGKINSVLLVAPRHGGSIEAAKSEVRRAIEASRRELLRMLVAEADATVPRPFRQEFWNMCKMVHLFYMEDDCYSSPKELVHAANMVVFDPLRVREL", "function": "Involved in the production of antifungal dolabralexin phytoalexins in response to biotic and abiotic stresses. In response to fungal infection and in associtation with AN2, is involved in the production dolabradiene, a type of antifungal phytoalexin. Converts ent-copalyl disphosphate (ent-CPP) to dolabradiene.", "AFDB_id": "AF-A0A1D6KUI6-F1-model_v4" }, { "swissprot_id": "Q1EMV2", "sequence": "MKDGMRVGERFTHDFVVPPHKTVRHLYPESPEFAEFPEVFATGFMVGLMEWACVRAMAPYLEPGEGSLGTAICVTHTAATPPGLTVTVTAELRSVEGRRLSWRVSAHDGVDEIGSGTHERAVIHLEKFNAKVRQKTPAG", "function": "Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Cannot use acetyl-CoA as substrate.", "AFDB_id": "AF-Q1EMV2-F1-model_v4" }, { "swissprot_id": "P32266", "sequence": "MNASPVRLLILRRQLATHPAILYSSPYIKSPLVHLHSRMSNVHRSAHANALSFVITRRSISHFPKIISKIIRLPIYVGGGMAAAGSYIAYKMEEASSFTKDKLDRIKDLGESMKEKFNKMFSGDKSQDGGHGNDGTVPTATLIAATSLDDDESKRQGDPKDDDDEDDDDEDDENDSVDTTQDEMLNLTKQMIEIRTILNKVDSSSAHLTLPSIVVIGSQSSGKSSVLESIVGREFLPKGSNMVTRRPIELTLVNTPNSNNVTADFPSMRLYNIKDFKEVKRMLMELNMAVPTSEAVSEEPIQLTIKSSRVPDLSLVDLPGYIQVEAADQPIELKTKIRDLCEKYLTAPNIILAISAADVDLANSSALKASKAADPKGLRTIGVITKLDLVDPEKARSILNNKKYPLSMGYVGVITKTPSSINRKHLGLFGEAPSSSLSGIFSKGQHGQSSGEENTNGLKQIVSHQFEKAYFKENKKYFTNCQVSTKKLREKLIKILEISMSNALEPTSTLIQQELDDTSYLFKVEFNDRHLTPKSYLLNNIDVLKLGIKEFQEKFHRNELKSILRAELDQKVLDVLATRYWKDDNLQDLSSSKLESDTDMLYWHKKLELASSGLTKMGIGRLSTMLTTNAILKELDNILESTQLKNHELIKDLVSNTAINVLNSKYYSTADQVENCIKPFKYEIDLEERDWSLARQHSINLIKEELRQCNSRYQAIKNAVGSKKLANVMGYLENESNLQKETLGMSKLLLERGSEAIFLDKRCKVLSFRLKMLKNKCHSTIEKDRCPEVFLSAVSDKLTSTAVLFLNVELLSDFFYNFPIELDRRLTLLGDEQVEMFAKEDPKISRHIELQKRKELLELALEKIDSILVFKKSYKGVSKNL", "function": "Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane.", "AFDB_id": "AF-P32266-F1-model_v4" }, { "swissprot_id": "P36093", "sequence": "MYHVPEMRLHYPLVNTQSNAAITPTRSYDNTLPSFNELSHQSTINLPFVQRETPNAYANVAQLATSPTQAKSGYYCRYYAVPFPTYPQQPQSPYQQAVLPYATIPNSNFQPSSFPVMAVMPPEVQFDGSFLNTLHPHTELPPIIQNTNDTSVARPNNLKSIAAASPTVTATTRTPGVSSTSVLKPRVITTMWEDENTICYQVEANGISVVRRADNNMINGTKLLNVTKMTRGRRDGILRSEKVREVVKIGSMHLKGVWIPFERAYILAQREQILDHLYPLFVKDIESIVDARKPSNKASLTPKSSPAPIKQEPSDNKHEIATEIKPKSIDALSNGASTQGAGELPHLKINHIDTEAQTSRAKNELS", "function": "Putative transcription factor that functions in pseudohyphal growth.", "AFDB_id": "AF-P36093-F1-model_v4" }, { "swissprot_id": "Q60760", "sequence": "MNNDINSSVESLNSACNMQSDTDTAPLLEDGQHASNQGAASSSRGQPQASPRQKMQRSQPVHILRRLQEEDQQLRTASLPAIPNPFPELTGAAPGSPPSVAPSSLPPPPSQPPAKHCGRCEKWIPGENTRGNGKRKIWRWQFPPGFQLSKLTRPGLWTKTTARFSKKQPKNQCPTDTVNPVARMPTSQMEKLRLRKDVKVFSEDGTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVESTMPSESKFLFRKNYAKYEFFKNPVNFFPDQMVNWCQQSNGGQAQLLQNFLNTSSCPEIQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPRHLQLLADLEESSIFYLIAGKKQYNAPNEHGMCIKPNKAKTEMKELRLLCAEDEQIRTCWMTAFRLLKYGMLLYQNYRIPQRKGLPPPFNAPMRSVSENSLVAMDFSGQIGRVIDNPAEAQSAALEEGHAWRKRSTRMNILSSQSPLHPSTLNAVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL", "function": "Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.", "AFDB_id": "AF-Q60760-F1-model_v4" }, { "swissprot_id": "Q09466", "sequence": "MPFDLLAERKRWNAGYESIDTSSQKLTEVVTPITVTWENIEVKTRKKLFSKKQKQLLNRVSGIAKPGEMVALMGASGAGKTTLMNVLMCRNMKGLEKNGTVKVNGTKIGKEISLISGFAQQQEIFIPTLTVDEYLMIQARLRMKANKHTRRERVDEIIEMLRLQNCRDLKIGTPGLVKGISGGEARRLTFACELLSNPSLLFADEPTSGLDSFMAASVVQILKNLANSGRTLIHQPTAELFFQFDKIIFLSMGKTAFMGTPHESVKFFADCGHPIPKLFNPPEWIQSKLSVIPNNETKSRETIGKIIEFYEKSIIHQKSIVEIRVIATTELPPYIENPGFFAETGALLKRACLDVIRSPAQMRMKLIQKVVMGLFIGSLYWQQPLDPRGVRNTNSALYFLIAELTFSTMFGIMTFMEHELPLIAREYHDGLFYVISYYISRFLSYLPLFTIDGALMIVISYWMIGLNSTWQQVAKSILISVLVEQSATSCGLFLACLFETTSLAIAFAVPASGLFALLSGLYGNTNNFPVYIRWMQWTSWCRYGFEGLVVNQWSQVDNPKWDPFYRELILKQFSFNKDNYQLDVIGLCSIVIFFYLAGYIALFIRIRLSR", "function": "Required for efficient RNA interference (RNAi) of pop-1 indicating a role in the germline development.", "AFDB_id": "AF-Q09466-F1-model_v4" }, { "swissprot_id": "P45763", "sequence": "MPESLMVIRSSSTLRKHWEWMTFSADSVSSVHTLTDDLPLESLADQPGAGNVHLLIPPEGLLYRSLTLPNAKYKLTAQTLQWLAEETLPDNTQDWHWTVVDKQNESVEVIGIQSEKLSRYLERLHTAGLNVTRVLPDGCYLPWEVDSWTLVNQQTSWLIRSAAHAFNELDEHWLQHLAAQFPPENMLCYGVVPHGVAAANPLIQHPEIPSLSLYSADIAFQRYDMLHGIFRKQKTVSKSGKWLARLAVSCLVLAILSFVGSRSIALWHTLKIEDQLQQQQQETWQRYFPQIKRTHNFRFYFKQQLAQQYPEAVPLLYHLQTLLLEHPELQLMEANYSQKQKSLTLKMSAKSEANIDRFCELTQSWLPMEKTEKDPVSGVWTVRNSGK", "function": "Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Plays a role in the complex assembly and recruits GspM resulting in a stable complex in the inner membrane. Provides thus a link between the energy-providing GspE protein in the cytoplasm and the rest of the T2SS machinery.", "AFDB_id": "AF-P45763-F1-model_v4" }, { "swissprot_id": "C0HKD7", "sequence": "MNTYVAEIGEIVRSQRRDEEYIEDITERLSRVSKELLGQRTWIRWFPYLKSIASTLYYTSTVVLGNQTLGEEYVHLFESNGLERTVPSIPSRISFVLLHSAFPLISNYLIQKAESTLTHPSTESFLGIPIRKNQKARQSFLDVFFWLRTKLFPQLQRAHIALFYITGAYYSIARRFTGIRFLSASAHSDIPALKVYRFLGYITLIQLAVSIGISLYSFLEQEKFNNKLKKEKKENNGGSDRNLDENSLFHPTFQCSICLENKNPSALFCGHLFCWTCIQEHAVAATSSASTSSARCPQCRLEFQPRDVTPLLNL", "function": "May be involved in the import of proteins into the peroxisome. Plays a role in lipid storage, most likely through its role in peroxisome function.", "AFDB_id": "AF-C0HKD7-F1-model_v4" }, { "swissprot_id": "P56812", "sequence": "MADEELEALRKQRLAELQAKHGDPGDAAQQEAKQREAEMRNSILAQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSGKVSEQGLIEILEKVSQQTEKKTTVKFNRRKVMDSDEDDADY", "function": "May function in the process of apoptosis.", "AFDB_id": "AF-P56812-F1-model_v4" }, { "swissprot_id": "Q9FCP2", "sequence": "MKMFAYRGKHENFGDELNHWLWERLLPGFFDEDESQLFLGIGSILYDNFDPNMQKIVFGSGYGGYTNPPKVDGNWTFYFVRGKKTAEVLGIDPSYAIGDSGILTRSCWDAKSIEKRYPVSFMPHYESAMYGSWDKVCELAGIHYIDPRWPVEKVLTEISASHKVVSEAMHGCIISDALRVPWRAIRPIAPGNRAKWYDWASALDLEIDFDPIGPSNVVEAGASLVRNNTYLLKNITFRHRRIRQLTGNYVFGSTVKTLQRVAEKPGQLSSDESMVNAHNRMLLELDRLKQDFSKKTASVL", "function": "Catalyzes the pyruvylation of subterminal glucose in the exopolysaccharide (EPS) repeating unit.", "AFDB_id": "AF-Q9FCP2-F1-model_v4" }, { "swissprot_id": "Q7TMV1", "sequence": "MAAVGPPQQQVRMAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIQSIYSQLMILNILVPIIGLITELPLHIRETVVLMSSLILIFNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITTQATVLMYILRMANETESFFISWDDFWDVICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDEIKDNSNASNNNGFIAPNENPNPEEALREDAAGSDRELNEDDSTDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD", "function": "E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination.", "AFDB_id": "AF-Q7TMV1-F1-model_v4" }, { "swissprot_id": "B4N1C2", "sequence": "MSEAKSEMYYSLLEWFKTLNLSAAHNNAEELADGLALAQALNQFAADFFTDSWLAKIKASAVGSNWRLRMSNLKKVTQSLYDYYSEVMNYTLSDFVRPDLQLIAEKCDQVELERLLQLVLGCAVNCAKKQSYITEIMGLEEELQANIMRALQELESTGLVAGERSPSSSASGGAGSGGAVNSLSRNSLSVKALQEERDAMAQKCFETEKKMLLLLDEKTNLQQELQKIQQEFARLEINTTAIGDDGVSLGPVQAGSVRFNEMRRQLDLLKEELLQSEGAREDLKLKAVQQESDLVHMQQRIDELLKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQIKILEERSADYVQQNAQFEDDAKRYANTKGQIELFKKEIQDLHSKLDIESGKNVKLEFDNKNLESKNLALQRAKESLVKERDNLRETVDELKCGHLTNNSGLTGCVEGTTMSRELQPTAMMDKIQRLEAENKALREGQGGQTALAQLLDDANKRCEHLRDQLKSANERILSLSHASQSDDPILKENEFAKQIKQLMELNEQKTLQLEEAVTQNASYQSKVIQLETSLSSREQEILACDAKYRKCVQKAKEIIKNIDPHIANAIDASALEKNMVDVVDEESKPKMSVMEEQLMTTAFYRLGVNAQRDAVDSKLAILMGSGQTFLARQRQSAPRKSLSAMKSK", "function": "Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity.", "AFDB_id": "AF-B4N1C2-F1-model_v4" }, { "swissprot_id": "Q38ZE5", "sequence": "MKIKESLAVGSFAFFGGILRYLIGLVLNQPTGFPYGTLCVNLIGAFCLPFLMRYIVARLHLSDQLALAIGTGFFGAFTTFSSFSVDAIRLVNQQQWSAFAWYVGISMVGGVLLSLLADYWAVKLTHNPEEQEVSQ", "function": "Important for reducing fluoride concentration in the cell, thus reducing its toxicity.", "AFDB_id": "AF-Q38ZE5-F1-model_v4" }, { "swissprot_id": "Q8MSW4", "sequence": "MARLKLRKLEEYLQGVDGFEQPKILLEQYPTPPHIAACMAHHMQSQHEDIEGKLVGDLGCGCGMLSIASTLLGAQLTVGFELDGDAVDTFRGNVVEMELPNVDCVRADVLQLIGSKWEKSFDTVLMNPPFGTKHNAGMDMRFLEVALRLANRAVYSLHKTSTRSYIQKKALEWGARGSVVAELRYNIDASYKFHKQKSKDIEVDFWRFEIGTE", "function": "Catalytic subunit of a heterodimer with Trmt112/CG12975, which specifically methylates the 6th position of adenine in 18S rRNA.", "AFDB_id": "AF-Q8MSW4-F1-model_v4" }, { "swissprot_id": "D4ZX34", "sequence": "MSSNNPTPNLEQLMLEARQLMKDLGLPDKMQGDTPIFVLLVMLDMKPAKSWSEANNQKWGITPLMNKMRELGFKNLAPNTRENIRDDCVGQLVDAELATENPDKPRPKNSPKYCYQINQEVLYLVKKIGSADYPIALNNFLSNYQTIKHKYQAKRQSQRLNVKIAHNFSVSIAPGGQGVLIKSVLQDFCKYFNIDKVLYIDNTVDTARGYSPFIDENLINYLGIDIDKFKNSYDKPDIVLYKSDNKYLIIIEAVKTGGAINVERRDRLLSLFENVDVKLSFVNAFESFKELKRLTKEITRETHAWIMEFPDHMIHFNGDQYLFH", "function": "A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-CTGCAG-3' and cleaves after A-5.", "AFDB_id": "AF-D4ZX34-F1-model_v4" }, { "swissprot_id": "C5DU00", "sequence": "MPMISDGFYKNLLINRVRHSTRVPILPRVPDLTTPLVTKFEKWSGKRRKLFFQNESQIHSYGIKDFELSNNLFAQLLSSPMRSERNCKTKMPKEFLMQLKLSSTQNNDSSKSLGLAPVVQHSKLNKNSYVVNSRDILSQQISSSTKWVPIAALTSQMRFFQMQDVAIDKSNFLNKYEEMLNSLLRDRLISASASKLEPQDGDVIVRFDKDGNRPIEIGQCKSIGNKEVKAILTNLKYIGPTWEQLINEHRNHEEGIVIRFSENEEAVKLLYKMLAYHYTH", "function": "Required for respiratory activity and maintenance and expression of the mitochondrial genome.", "AFDB_id": "AF-C5DU00-F1-model_v4" }, { "swissprot_id": "A8ZNS3", "sequence": "MLIDPLTVVAQIINFLILVALLRRFLYTPITQVMKKRERLIAQQLQDAAHQQEVAQQEAERWRQMQQSLEHRQASFLTQAQDAADEHRHQLLQQIRDEVDSTQAQWREAVKREQHVFLSALQQRAGQQLAATLRCILQDLASANLEQQILETFITRLSHLPFSEQGVLETSLSNARGEELVISSTFPMPEDRKAQILAVLHQYAPAMESSVYQFVTIPDLICGIELKIPGYKLAWTIEQYLEQLEVKLNQVWDGMEKSWVEQG", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-A8ZNS3-F1-model_v4" }, { "swissprot_id": "Q6CG11", "sequence": "MMISCTRTAILPLRRRLMTASTAYPIKFASSIIPGYGRGSADLGIPTANIPIDDVPVLDALDTGIYYGLVQILKTDKPSEKKTSEFQKDRVVDFQYTNKLNDQEINAVLPMVMSVGWNPFYKNDQKSAEIHIIHKFAHTFYGASIKVMVLGYLRPEKNFTSLEALVDEIHNDIKVSEEKMEGTREKKDQFWQ", "function": "Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.", "AFDB_id": "AF-Q6CG11-F1-model_v4" }, { "swissprot_id": "A9QM73", "sequence": "MMTLQMDKTTASSSWERAKSIYDEIAELANKRQKAGNPPDPNLLQLLREKYEAIILESHTFSEQHNIEIPLWQLHYKRIEYFRLHINRVLASSTSTAAQNVKGPSKAEQIAQLKLQFRTFLSEATGFYHDMILKIRSKYGLPLGSFSEDQQSQNLSDKDGKELAEVQKALKSCHRCLIYLGDLARYKGMYAEGDSRSRQYASASSYYLQAASLWPASGNPHHQLAIVASYSRDEFVTTYRYFRSLAVEYPFPTARDNLIVAFDKNRQSYEKLFVPSKDSSKRLTGKGRGKGADISLKDATLVAGPEKDKVTIANEMLKAFSIRFVHLNGILFTRTSLETFFDVLASTSSSLREVISLGSAKELTLGIDTSDSALFIVRVVTMLIFSVHNSKKETEGQSYAEIVQRVEPARNSLTASFELLGLVIEKCVQLGDPSSSYFLPGVLVFVEWLACCPDIALGSDPDDRQTAVRNSFWNQFVVFFNQVLSLGPTFIDDVEDETCFSNMSLYDERETENRLALWEDYELRGFLPLLPAQTILNFSRKHSFGTEGPKEKKARIKRIFAAGKALTSVIKVDQNHVYFDSKKKKFLVGVKPADDFLDSHSSPPKACNALQDNQVMIDHNSPIMQLDQQIYMGEEDDDDEVIVFKPLVTEKRKEASDQIYVPSGGFRKSDQVTTMGDFKALSGSDVAFHENQILQARGNASIQVPASVGANLLGPLQPSTQSQAMHMQQVQTQVQVPASVGANLLGLLLTSTQSQAMHMQQVQTQAVNPQPAQSLAASRLQPIQSQVAQPLPSRVVHFQQTQAQVSHVSPAHSQSTSFGGGSKWSPEEAASLASSLSGFAQLGNGHVMRNEMQGNHGVSYYPAHSLPVHQSYNGNGMGGMPYSQSRTPEAVFPPKIDPVLSSGVVADGLGVQSSLAKKNPISRAFRHLGPPPGFNSVPAKLQKEPAPGSELSGNNHLPVDDYSWLDGYQAQSSRGVGLNSSLNYATSGKPEHLGSTGNGLNGPANFPFPGKQVPTSQVQADFPYFQNPQKDNFVDKNHQSTQLPEQYQGQSTWSSRHFV", "function": "Plays multiple roles in growth and development. Involved in nonsense-mediated mRNA decay (NMD). May provide a link to the mRNA degradation machinery to initiate NMD and serve as an adapter for UPF proteins function. Required for meiotic progression through anaphase II of pollen mother cells. May counteract cyclin-dependent kinase (CDK) activity at the end of meiosis. May play a role in plant defense through its involvement in NMD. Together with EXA1, helps to restrict cell death induction during pathogen infection in a salicylic acid- (SA) and reactive oxygen species- (ROS) independent manner.", "AFDB_id": "AF-A9QM73-F1-model_v4" }, { "swissprot_id": "Q7NDR9", "sequence": "MTSFSAPGSPVDTVLLTSPAGAGRTEAIRIFEDLGYLCLNHVWPELVPTFLKHYAPIAPRLVLCLASRPEADAQAGLIAARVALRSLARTTVHVHLDCPEGVLLSRYALTRRPHPWFDHGKGLLAAIRAERTALEPVRALADEVVDTGPLELAQLRVHLGALVGGRPTELPVTVMSFGFKRGVPADAQFVLDIRFLPNPYYESALKPLTGLDVGVAEYVFASEQSQATYRSLLEFLRFLLHQYRQDRRSQLLIAIGCTGGQHRSVAFVERLSGDLAAEGFACRPSHRDLAVNRLQELSR", "function": "Displays ATPase and GTPase activities.", "AFDB_id": "AF-Q7NDR9-F1-model_v4" }, { "swissprot_id": "P53551", "sequence": "MAPKKSTTKTTSKGKKPATSKGKEKSTSKAAIKKTTAKKEEASSKSYRELIIEGLTALKERKGSSRPALKKFIKENYPIVGSASNFDLYFNNAIKKGVEAGDFEQPKGPAGAVKLAKKKSPEVKKEKEVSPKPKQAATSVSATASKAKAASTKLAPKKVVKKKSPTVTAKKASSPSSLTYKEMILKSMPQLNDGKGSSRIVLKKYVKDTFSSKLKTSSNFDYLFNSAIKKCVENGELVQPKGPSGIIKLNKKKVKLST", "function": "Could act as an H1-type linker histone. Has been shown to bind DNA.", "AFDB_id": "AF-P53551-F1-model_v4" }, { "swissprot_id": "P45781", "sequence": "MRAKQRGVALIVILLLLAVMVSIAATMAERLFSQFQRATHQLNYQQAYWYSLGVEALAKKGIEQSYQDSETINLSQPWALKEQTYPLDYGQVRGKIRDMQACFNLNALAGVKLTPDSVKKPYLLTVLQALLEGLEVESYQAEVIADSTLEFIDKDDSVRTAYGVEDSYYESMIPAYMAADTWLADASEWRAVQQVGGETMNKALPYVCALPTDQWRLNVNTLPAEQAALLAAMFSPTLSPESAKTLLEGRPFDGWASVDDFLAQSALTGVDNAVREEAKKYLSVDSHYFELDAQVLVDTSRVRIRSLFYSNDKKTATVIRRRFGGISERVSDRSTE", "function": "Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Plays a role in pseudopilus assembly and seems to control its length. Interacts with the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.", "AFDB_id": "AF-P45781-F1-model_v4" }, { "swissprot_id": "Q6ZQX7", "sequence": "METRGPGLAVRAESRRLVGIGPRAPPGRVGLQPSGRLDRRGGAGTMGYKDNDGEEEEREGGAAGPRGSRLPPITGGASELAKRKVKKKKRKKKTKGSGKGDDKHQSQSLKSQPLSSSFHDILSPCKERGPKPEHRQSKVEKKHLPSDSSTVSLPDFAEIENLANRINESLRWDGILADPEAEKERIRIYKLNRRKRYRCLALKGFHPDPEALKGFHPDPDALKGFHPDPEALKGFHPDPEALKGFHPDPEALKGFHPDPEALKGIHPDPEALKGIHPDPEALKGFHPDPEALKGFHPDPEALKGFHTDPEALKGFHIDPEALKGFHPDPKALKGFHPDPKALKGFHTDPEALKGFHPDPKALKGFHPDPEALKGFHPDPEALKGFHPDPEALKGFHTDPNAEEAPENLPYLSDKDGSSSHRQPTSKAECPNLCFEGNLTPKLLHSDLAPTLLE", "function": "May be involved in ATE1-mediated N-terminal arginylation.", "AFDB_id": "AF-Q6ZQX7-F1-model_v4" }, { "swissprot_id": "Q86VZ1", "sequence": "MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF", "function": "Probable receptor for purines coupled to G-proteins.", "AFDB_id": "AF-Q86VZ1-F1-model_v4" }, { "swissprot_id": "P28369", "sequence": "MLETETGRYSDTLRSALVSLDGDNAWALSESWCGTIQWICPSPYRPHHGRKNWFLGIGRFTADEQEQSDAIRYETLRSSGPGGQHVNKTDSAVRATHLASGISVKVQSERSQHANKRLARLLIAWKLEQQQQENSAALKSQRRMFHHQIERGNPRRTFTGMAFIEG", "function": "Could be involved in translational termination.", "AFDB_id": "AF-P28369-F1-model_v4" }, { "swissprot_id": "Q6B909", "sequence": "MKNKITVILKKNLANLGSIGTVVKVSSGYAFNYLIPRDFAQLATQGSLKHHKMFLDMKQQKLDEIQDKLQASAQKFNKISKISVKKKVGNNNQIFGSVNDKEIISKLFSITGEKLEKKNIYLPNIKALGIYNLNIIFTSDIQVSMKLQILPFFA", "function": "Binds to the 23S rRNA.", "AFDB_id": "AF-Q6B909-F1-model_v4" }, { "swissprot_id": "O51498", "sequence": "MKELYLIDALNIIFRNYHVMKNYPLLNTQGENVNAFIGFFKTLFFIIKEKNPEHLIITFDSEVPTFRKQKYPSYKATRDLPPDDLIPQIGWIKEGLLKAKIPIFEMEGYEADDLLASFAKKAAKNNYLTYIISPDKDLLQTMSEYVKILKIENNSFIEMDNEYVTKKFGVNSFQIKDYLAIVGDRSDNIPGIKGIGAKGAANLLREFKTLDGIYSNLEIINKKHRELLIKEKENAFLSYELVSLEENLKIPEIENFALKNFSEEIISLFEKHSAIALIKTYKKDILKQEKENADQKSLFKQEPTTNSLDDINTIDTENVKYRSITTKIELDDLIESLKKAKYISIDTETSSLDTYTAKLIGISISFKEFEGYYIPIEAKGKIYIEKNYIIQKFNNLFESNPKIIGQNYKFDYKILKNNGFNPIPPYFDTMIAAYLIDTNSKVSLDFLAEKYLMHKNIKYEDVIQKNDNFANISLEMATSYSSEDADITFRLFNIFTKKLKEDKLDKLMHEIEMPFNKVIIEMEENGIYLDKEYLKEYGKELGKELEAIENEIIKSIGIDFNLNSPKQMHEILFEKLNLKLPEKMKKDSTDIKVLESLREQHESIENLIKYRQIAKLKSTYTDNLIELINYKTNRLHTSFIQTKTATGRITSINPNLQNIPIKDEKGRKIRKAFKPENGNIFISADYSQIELAILAHLSQDEVLIKAFENNKDIHTETASKLFKIEEKEITPNLRRIAKSINFGIIYRMSDFRLAKELGITKEEAKGFINSYFDSYPKIKEFIINQINFVRNAGYSETILKRRRYIKEINSNNYLERSAAERIAINSIIQGSAADIMKIAMVKVFNEFKSKKMESKILLQVHDEMLIESPIEEENEVKKILKIMMETAYTLNLPLRANIETGKSWGEIH", "function": "In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.", "AFDB_id": "AF-O51498-F1-model_v4" }, { "swissprot_id": "Q1K9C4", "sequence": "MPLSFEGTFKAKRNVNLGGKRVSNDRAQLLRKAAMERKNREEERKAENNSVAVQSLSRGFLARRKFKQDFRERWIYKYTKSGRTSIRFNTLEDIKCSISLLVLFAEPDIDLPFVSQVAHNILVWLENLIPLSNGMDDTPKSHLKVKILKVQETLSNSNDSWLWQRFSSLLLNCLVSSINSHRIEGTDTSAETSLLHCLAYVAPYLKSSELSTYYDSVMTFYAQIYPKQNMTNLEDIMSLSLLTPVSSKTDENANSSSAFLFHVLASDCFSSIENCIPPDLIIDKVFSSSLQLSEEACISSLLNLGMIKVFSLAGNCLHLLHTEYKNSSLWKFCSYILDALYVFSGESVNSRIQVVSDVDDDEDDENAFSQNYYSHLQMVAKHFSKNYANQSGIVQRSFAECISSTFITKAFKLVSSNTLQAMSHFYATMIKLFPSNRTSILMYISLVETNEGSLTRSFSRFSWDMFSESPVYQLFHKKFDVQNVLKNDSGYWFQLQLLIDVYSRMLFTMIDDEFHNDKQNPLYPVMAEFCTVLKNLVLGLYWDVQAAKDVDCKSVVDISQLRVSSTSLLQQLYRINSRKQFLPEDFFLMSEYFNLNEFEANALQESELASHAEAEINITYKFDNFSESRPRLNILNNCSFFLPFHFRIHLLQQLLLLDKQANGYAQPFGHLKHAVIRRNRIFDDGFDAFYNFGKLLKGPIRITFVDEHGVVEEGIDGGGLTKEFLTSICKTVFDINYGLFSETKAHLLYPNTHAYAQDVERLRCYEFLGMLIGKCIYEGIQIDAAFASFFVAKWLGHPSYFDDLTSLDPNLYEGLVFLKNYDGDVENDMALNFTVVHEEFGVRNVIDLIPNGSNISVTNENRLQYIHLVSNYYLNARLSRQCRAFTNGFTQIIDPHWLAMFHESEIQILVGGDPVPIDIDDLRRHTVYAGGYEPNSPTIVLFWEVLREFEEEDKRSFVKFVTSVARPPILGFKALMPSFCIRVNGEDETRLPTASTCVNLLKLPMYSTKQTLRDKLLTAVRSGVGFGFS", "function": "Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q1K9C4-F1-model_v4" }, { "swissprot_id": "Q17027", "sequence": "MKCATIVCTIAVVLAATLLNGSVQAAPQEEAALSGGANLNTLLDELPEETHHAALENYRAKRATCDLASGFGVGSSLCAAHCIARRYRGGYCNSKAVCVCRN", "function": "Responsible for the anti Gram-positive activity of immune hemolymph.", "AFDB_id": "AF-Q17027-F1-model_v4" }, { "swissprot_id": "P45067", "sequence": "MNILKRKTPQNIRFGEQKPKYYFHIRAFAVLLGVFFLLGVYFNWQSILEKMDDKPISAFALVGQNTFTTADDIKESLLKMGELKGFWGQDVAPIQEQIEALPWVKGAIVRKMWPNRLSIWVSEYQPVAFWNQNQFVTLDGIVFQLPSVRLTAKNLPYLGGPDYQSLKVIETWNQIYINLKSNNIMAKGINIDDRGAWQVQLDNDIVLKLGRGDWKSKLERFVTIYPQIDVPENKKIDYIDLRYTAGAAVGMVDR", "function": "Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.", "AFDB_id": "AF-P45067-F1-model_v4" }, { "swissprot_id": "Q43257", "sequence": "MAAQLHHALYELLHEAAAAQRALLLAIPFSLLLLPLLLRYLAASASASATKNDGAAPASDPDKLLSLLPSPPMKLPIIGHLHLMGDIPYVSLAALATRYGPDLMLLRLGAVPTVVVSSPRVAEAVLRTYDHVFSSRPRSLVSDIIMYGATDSCFAPYGDHFRKARKLVTVHLLNASKVRSQRPAREEEVRGALDRVRRAAAAREPVDMSELLHSFVNNLVCRAVSGKFSMEEGRNRLFRELTDINAGLLGGFHIQDYFPRLGRIELVRKVACAKTRRVRKRWDDLLDKLIDDHAARMATHQDEDDDKDFIYVLLSLQKEYGLTRDHIKAILIDMFEAGTDTSYMTLEFAMTELIRKPHLMKKLQEEVRRNVPAGQEMVTEDNLPGMTDLKAVIKETLRLHPPVPLLLPHYSLDACEVAGYTIPANTRVVVNAWALGRHSGYWERENEFVPERFLSGDVAGGVDLKPNEFQFLAFGSGRRMCPGVHSASATIEAMLSNLMYRFDWQLPAGMKAEDVDMTEVFGITVSRKEKLLLVPQAA", "function": "Catalyzes the conversion of indole to indolin-2-one.", "AFDB_id": "AF-Q43257-F1-model_v4" }, { "swissprot_id": "P29780", "sequence": "MSLVGVHNEWDPLEEVVVGTARRPCAGPDRSLLAVEYAEYAGPGRWQEVPTGPYPDRALKETEDELEELCEELRGLGVTVRRPGARDSAAPVRTPDWESDGYGDLCPRDGLLVVGDTVIEAPMALRARFLESLAYKELLVEYLAAGSRWISAPKPRLAEGMYSPSGPSGERLRDLEPVFDAANVLRLGTDLLYLVSDSGNELGARWLQSALGAAYTVHPCRGLYSSTHIDSTLVPLRPGLVLVNPARVTDDNLPGVLRTWQRIECPALAGLGYAGDVPHCSTWIGMSLLVVRPGLVVVDSRHRELMRVLERHGVDVLPLKLTHARMLGGGFHGVTLDIRRTGALETYRF", "function": "It is not obvious if strB2 participates in streptomycin biosynthesis as an inosamine-phosphate amidinotransferase. Attempt to measure its activity have failed and the nucleophilic cysteine which is the key residue for amidine transfer is not conserved but replaced by a glycine residue.", "AFDB_id": "AF-P29780-F1-model_v4" }, { "swissprot_id": "A5GN10", "sequence": "MVLPASMRLRGHRCFDHLHRRGKRYYGTWMVLRKAPSNAKLLRRDIHGLLTQTQPHSCRIAVVISGKVHKRAVVRNRLRRLLHDHLRLRFEARSTHSDVWLLISLRPGADADEANLLEECDRLLEEAGLQP", "function": "RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.", "AFDB_id": "AF-A5GN10-F1-model_v4" }, { "swissprot_id": "Q47WN5", "sequence": "MTITTSKQLPSLAQLPETYLIELSEFGAISLSGEEQSKYLQGQVTCDVNSITESNLLVGAHCDAKGKVFSVFRLINRSSAHLLLQPTASIEGSLKELKKFGVFAKVTIDIAEELGFIALIGKQASSLIQQEFSQVPDSLTPVVQIGSTSLVYLSGEQPRYIIIDDKATITAITEKLALPTYSQSVWNLLEITQGFPILTANTSGHYVPQMLNLQAINGISFTKGCYLGQETVARMQYLGKNKRALFCLNSQLEQPFQSDDVIEKQLGENWRKAGDILAHYQADDGSCVIQAILANDGDLPILRIASQADSVVTNQTLPYTLIAE", "function": "Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.", "AFDB_id": "AF-Q47WN5-F1-model_v4" }, { "swissprot_id": "P18065", "sequence": "MLPRVGCPALPLPPPPLLPLLLLLLGASGGGGGARAEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ", "function": "Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.", "AFDB_id": "AF-P18065-F1-model_v4" }, { "swissprot_id": "A0A1B4XBH1", "sequence": "MSFTFLDWPRAEIFSSVSYLGLLLSGTVLYTVYKLIIAIYNYFFHPLRKIPGPPLASISWVPWYKYWFSGYMHRHVTRLHETYGPVVRIGPSEISFISATAWKDIYGLKRCRQIERDPQSFPSLTPNGARFDVLTYSPIDHAKYRKILNPCFSEKATREYERTIHENVDKLVAKLEQNISRGQKKNGSRENVTNWFQWLTFDMVTDVCWGRSFECVANEKSHVCLALSMDLVSYSSFIVFVAWWKGLKDFLVKLSGVEGLFVHLVRSKCEEHHLIAAGNELTGEKGKASIYSNLRAAGDPLDLAELDGNLTAIVIAGSETTGFALTATSYYLAKNPACFRRAASEVRSAFASAEEINDDALRKLPYLKAAIEEALRMTPAEPNGLARKVVVDGGLDIAGEWIPKGTAIYVSQFAANRSSAYFHLPNEYHPERWLGEECPKEFRTDKLDAVQPFIMGVNVCIGRGLAWMEMRVTLAKLLWHFDWTVKGGDGEAFEQAKAWHVWTKSHVNLQLHRRGALYGDL", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sordarin and hypoxysordarin, glycoside antibiotics with a unique tetracyclic diterpene aglycone structure. First, the geranylgeranyl diphosphate synthase sdnC constructs GGDP from farnesyl diphosphate and isopentenyl diphosphate. The diterpene cyclase sdnA then catalyzes the cyclization of GGDP to afford cycloaraneosene. Cycloaraneosene is then hydroxylated four times by the putative cytochrome P450 monooxygenases sdnB, sdnE, sdnF and sdnH to give a hydroxylated cycloaraneosene derivative such as cycloaraneosene-8,9,13,19-tetraol. Although the order of the hydroxylations is unclear, at least C8, C9 and C13 of the cycloaraneosene skeleton are hydroxylated before the sordaricin formation. Dehydration of the 13-hydroxy group of the hydroxylated cycloaraneosene derivative might be catalyzed by an unassigned hypothetical protein such as sdnG and sdnP to construct the cyclopentadiene moiety. The FAD-dependent oxidoreductase sdnN is proposed to catalyze the oxidation at C9 of the hydroxylated cycloaraneosene derivative and also catalyze the Baeyer-Villiger oxidation to give the lactone intermediate. The presumed lactone intermediate would be hydrolyzed to give an acrolein moiety and a carboxylate moiety. Then, [4+2]cycloaddition would occur between the acrolein moiety and the cyclopentadiene moiety to give sordaricin. SdnN might also be involved in the [4+2]cycloaddition after the hypothesized oxidation to accommodate the oxidized product and prompt the [4+2]cycloaddition. GDP-6-deoxy-D-altrose may be biosynthesized from GDP-D-mannose by the putative GDP-mannose-4,6-dehydratase sdnI and the short-chain dehydrogenase sdnK. The glycosyltransferase sdnJ catalyzes the attachment of 6-deoxy-D-altrose onto the 19-hydroxy group of sordaricin to give 4'-O-demethylsordarin. The methyltransferase sdnD would complete the biosynthesis of sordarin. Sordarin can be further modified into hypoxysordarin. The unique acyl chain at the 3'-hydroxy group of hypoxysordarin would be constructed by an iterative type I PKS sdnO and the trans-acting polyketide methyltransferase sdnL. SdnL would be responsible for the introduction of an alpha-methyl group of the polyketide chain. Alternatively, the beta-lactamase-like protein sdnR might be responsible for the cleavage and transfer of the polyketide chain from the PKS sdnO to sordarin. Two putative cytochrome P450 monooxygenases, sdnQ and sdnT, might catalyze the epoxidations of the polyketide chain to complete the biosynthesis of hypoxysordarin. Transcriptional regulators sdnM and sdnS are presumably encoded for the transcriptional regulation of the expression of the sdn gene cluster.", "AFDB_id": "AF-A0A1B4XBH1-F1-model_v4" }, { "swissprot_id": "A5CSN2", "sequence": "MTTTVAVVGATGRMGQLISQIVEASTEFELVASLDSKDELSDMLGADIAVDVTLPAVSQGVVEYAVAHGMNVLVGTSGWTGERITELERRITGKLAVGVVIIPNFSVGSVLATSFAQMAARFYDSIEIVEAHGASKIDSPSGTAVRTAELMSQARGARGPVQAPHTDQRARGQQVASIPVHSLRMQGVVAKQDVVFGGNGEVLTISHDTLAPSAYEAGILLALRATRTARGVVVGLDRLIDLDGSRERAAQAAAGDAPSGPVDDGGPSGQAATVTSA", "function": "Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.", "AFDB_id": "AF-A5CSN2-F1-model_v4" }, { "swissprot_id": "Q18071", "sequence": "MLEISPWETLVKLLTDSLLNCTGTHEDVPHAKTFLRSLTTTYIASLAVATAVTVGTVCLAVLHLIYIHFYITHSSRRLHIVLLACTAPLVSLLALVAMYMPRVWFLSHLLSFLYFSFALWVIICLLLHIFDGHHALVTKMMQRLQYVEIATPPFCCLFPCLPKVRLEGKKIRWCELMVMQAPIVRLFATLVSLVIYFEYQDQGLVPLKVLDFITLPSLLAGIYGTHILVTTVSRMDELISYRYVVVFRLLDFFFMVFGLQQPVFDFLARYGAFGCGTVLPAIETSFYWKNFFTVIEAFCVTLISTVLLQPSKSSFFDKHPSCRSMSSARSTITDVDTDESTT", "function": "Probable transporter.", "AFDB_id": "AF-Q18071-F1-model_v4" }, { "swissprot_id": "Q28R42", "sequence": "MRHTLPIAPQFYVTAPQACPYLDGRRERKLFTALQGDQAETLNNSLSKQGFRRSQNVLYRPSCTDCAACLSARIRVADFAPRRGHKRISRRNEHLFRNPRSAWATEEQYALFRTYLDTRHADGGMADMDVFEFAAMIEETPVKTRVIEYRDRTDGDDLAAVCLTDILDDGLSLVYSFFAPELQKNSLGTYVILDHIALAQEAGLPYVYLGYWVPGSTKMGYKASFPALEVHVNGDWQDIGDPADYDTQTHPLSTDPIAQQVAQITLPDLRGENGRSDGLRGFSDGP", "function": "Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.", "AFDB_id": "AF-Q28R42-F1-model_v4" }, { "swissprot_id": "O35385", "sequence": "MGSSSSTQHHFAFQNAEKAFKAAALIQRWYRRYMARLEMRRRCTWNIFQSIEYAGQQDQVKLHEFFSYLVDHFTPSSHHERDFLNRMFTEERFAQDVETEEGGDFESIEVPDSYTGPRLSFPLLPDHATALVEAFRLRQQLHARYVLNLLYETRKHLAQLPNINRVSTCYSEEVTVCGDLHGQLDDLIFIFYKNGLPSPERAYVFNGDFVDRGKDSVEVLMVLFAFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFCWLPLATLVDEKVLVLHGGVSDKTDLELLAKLDRHKIVSTMRCKTRKESENREEQKRKDNQTSSGQKPTPWFLPQSRSLPSSPFHLGSGFKAYKAGRSCSIPCGSPNSKELSRRGQVRRSVDLELEQCRQQAGFLGIREKGESLPLAPDADCVADGGGVLEPTPEEWKQVVDILWSDPAAQEGCKANAVRGGGCYFGPDVTERLMEKYKLQLLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKATHRLTMRQRISRVEESALRALRQKLFAHSSDLLVEFRKRDPDESGVITLSDWATAVESVLHLGLPWRMLRPQLVNSSADNVLEYRSWLDSLAKEQLSRENIQSSLLEKLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMSIDITDDGICDLARSIDFNKDGHIDINEFLEAFRLVEQSCLEGHASACLQSTDTAESGHSSPGPC", "function": "May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.", "AFDB_id": "AF-O35385-F1-model_v4" }, { "swissprot_id": "O00329", "sequence": "MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ", "function": "Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.", "AFDB_id": "AF-O00329-F1-model_v4" }, { "swissprot_id": "P15743", "sequence": "MTSTKNLAKAIVILYAICFFTNSDGRPMMKRSVSEMQLMHNLGEHRHTVERQDWLQMKLQDVHSALEDARTQRPRNKEDIVLGEIRNRRLLPEHLRAAVQKKSIDLDKAYMNVLFKTKP", "function": "PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.", "AFDB_id": "AF-P15743-F1-model_v4" }, { "swissprot_id": "O75170", "sequence": "MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQDVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVDSFSQGLERSYAVSSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPPHENGNRSLETPQPAASLPDNTMVTHLFQKCCLVQRILEAWEANDHTQAAGGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLVSTHHLHSSSEDEDIEGAFPNELSLQQAFSDYQIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRIQPFDDDEDEDIWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKASQASYFAVSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALNGPV", "function": "Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.", "AFDB_id": "AF-O75170-F1-model_v4" }, { "swissprot_id": "P82604", "sequence": "MKNMPENHNPQANAWTAEFPPEMSYVVFAQIGIQSKSLDHAAEHLGMMKKSFDLRTGPKHVDRALHQGADGYQDSIFLAYWDEPETFKSWVADPEVQKWWSGKKIDENSPIGYWSEVTTIPIDHFETLHSGENYDNGVSHFVPIKHTEVHEYWGAMRDRMPVSASSDLESPLGLQLPEPIVRESFGKRLKVTAPDNICLIRTAQNWSKCGSGERETYIGLVEPTLIKANTFLRENASETGCISSKLVYEQTHDGEIVDKSCVIGYYLSMGHLERWTHDHPTHKAIYGTFYEMLKRHDFKTELALWHEVSVLQSKDIELIYVNCHPSTGFLPFFEVTEIQEPLLKSPSVRIQ", "function": "Catalyzes the stoichiometric dehydration of Z-phenylacetaldoxime to phenylacetonitrile. Prefers the Z-form of phenylacetaldoxime over its E-isomer.", "AFDB_id": "AF-P82604-F1-model_v4" }, { "swissprot_id": "Q9KIZ4", "sequence": "MTQEQANQSETKPAFDFKPFAPGYAEDPFPAIERLREATPIFYWDEGRSWVLTRYHDVSAVFRDERFAVSREEWESSAEYSSAIPELSDMKKYGLFGLPPEDHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQEEFDVVRDYAEGIPMRAISALLKVPAECDEKFRRFGSATARALGVGLVPRVDEETKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRRDTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLKETPVFGYHPAFRNIESLNVILKPSKAG", "function": "Involved in the biosynthesis of epothilones, macrolactones which have a narrow anti-fungal spectrum and microtubule-stabilizing activity. Catalyzes the epoxidation of epothilones C and D to epothilones A and B, respectively.", "AFDB_id": "AF-Q9KIZ4-F1-model_v4" }, { "swissprot_id": "F4HT77", "sequence": "MTSVSPRYRNVPVPKVFLSFRGEEIRHGFISHLADALERYGIMFIIDKDEQRGNDLTSLLLRIKESKVALVIFSSRFAESRFCMDEIVKMKECVDERKLLVIPIFYKVRARDVSGRTGDFGKKFWALAQKSRGCQIKEWMEALECISNKMGLSLGDGRSEADFIKEIVKEVERVLATFTSEDTEDHHCQTVKLLKGLVVGCLAHQELPLVLVFTQVYYYVKFSIFFIEEIFSSCFRKGFVLKPCKEDLQINSISIPGIDLENFKNMMQQAMYELNQMLLQSLGNIDPHRDVAFENQPQDQPDSPIALPEERRVALEATKFCGHAAYWWNQTKTTRARIGKVLIHFWEKLKKKFKDTYDRTVRI", "function": "Disease resistance (R) protein that specifically recognizes the HopBA1 type III effector protein from P.syringae, and triggers cell death. Acts as a NAD(+) hydrolase (NADase): in response to pathogen-recognition, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death. In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR, for which the cyclizing bond is unknown. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules.", "AFDB_id": "AF-F4HT77-F1-model_v4" }, { "swissprot_id": "Q6ZT07", "sequence": "MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARVAPYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGKIQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMYLSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKADSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLTSCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQLLDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDITPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKSKSKNAKDLPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQPAKEGGSGGSGPSCHQGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEHSLGGQMEDIKLEDSSPRDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIGEDTVLVRSGQGTAALPRSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAKNIRMMGKPLTSASDYEISAMSG", "function": "May act as a GTPase-activating protein for Rab family protein(s).", "AFDB_id": "AF-Q6ZT07-F1-model_v4" }, { "swissprot_id": "Q6DJL7", "sequence": "MGDVRTQLTPETPGRAAILNPFESPSDYCSLHEPFVSSPSVFKPSKSAATPQQFRWSIDQLAAINPIEIDAEDIHRQALYLSRAKTDKETEERRQKAIEEFFTKRTIVPSPWTQHEGKPAAPFHSTKCADLIHESPVGRVQAVQSGKSTVGCQTHLSLPVDFNLEKVLGEYFRAEETADQSQDNLSSSSLRRKLFLDGHASGSECSSPSSPPQEGPYYDPPAALGVLCSIDLSPVRCRSPTQTPSSGQFSSSPIQGGRRAFSLGSITSPTFLEKSPASVTSPSFSPIAINLGKTPDAEQKRLIFPSPETLSASTSMVNAFTRNPYIEGCSPIKSIFQIKSRSCRGNAPHRTSLFQIPFALEPHSDDKENSPPSSIKSPEGDLSSLFHQLENIVPDGHVMMGGEPIVSPTVYMQQEYLQSEELKENDTVEMVEPVEIEEEHSWPKETVATDNIPMASFMTGITFSGESSHMCMSPLAESSVIPCENSSIQVDSGYNTQTYGSCIMDGIGAETTYKENDTHISDIQNKCQHFKVKDISSVDCKNQLLEPESPEFQHSTQKSQNKLARYSLNSGMWKLTGDGAINRLNKNGGVQSPPRTLNPKSLSHFLQ", "function": "Required for the activation of aurka at the onset of mitosis.", "AFDB_id": "AF-Q6DJL7-F1-model_v4" }, { "swissprot_id": "P30962", "sequence": "MTLIDLANPTRFLALTARVLPWLAAATVILLAIGLYQSALAPDDYQQGATVKIMFIHVPNAWLSMFVWGVMSIASLGTLVWRHPLADVAAKAAAPIGAAFTFLALLTGSLWGRPMWGTYWEWDARLTSVLILFLMYLGLMALWRAVDDPSRAARAAAVLTLVGAINLPIIKFSVDWWNTLHQPASVMRMGGSSLDKSFLIPLLVMAIAFTLLFVTLHLAAMRNEILRRRVRSLQMMQASRMAFSSEMGAGSRQNNASNEVGAA", "function": "Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.", "AFDB_id": "AF-P30962-F1-model_v4" }, { "swissprot_id": "Q6C519", "sequence": "MITVTPGELATIDDALTDLLLERVFYWAEVRKASVHYKPLRGISDRHIHDLVRSIAACETGAAANLAVKKATNAFLELKEVRGYRGRLSPLAYEEFQRHTVRYLTIYKASCGFEINVSMRYKCRSNRGESCVISRVRYNRGDEIVGLSGCLAKMTKDEELALANDFSVLHSSRRGGNCLMLGPARFVNHDCSANARFVPVPSGMVIQAVKPINVGDEITVKYAENYFGRRNKECLCQTCEENSRGLYGSPQESSEEESDDDMDELTKIELQRRKKRQEQREGGTPELREGGRGSSESSRETSEEAIEISTSKNWPLIPKIESHTADSTPLPVPVGEVSEATVTEVSTVVPAQEAIPVNESTTALSQSSNEFQDPTIDPILNGASAEIRFPSLPSPDTTTSPESQVPPFIQPKSARRNHHYLGMHNTDERVRFNDRLSVLDERGGSEDMESCLVSGSESRDDSTAMSRDEESSRDDGDGSRSKRSKRHVRAQRKNSGSWSFSQEDLSFDRLCKAAREQAYDPSRYALTGVYGFSVSGATQTCVSCCSVYNLTDGPKTLGHFCPRCHRHAAIHSFAWPYTNHKHALPLCLLMMRPPKKLEDEDWGLSKPQVAQQFGAKNRKIFEEDGSLVQKKRKSLAWSWEYTKEEPAQEITSMRIEDMSPKELKKWSQAGRQTRSGRVSMLPEKPKRSRKSAPEPVEMRDNVAQLSREERAWKRARRGTVGHEKVEVNTPTVETPSTGTPKVKKLHWKQKLAMERRQKEAEAAEVAETRVADGVDASTPSPAGSTPTPRGRGRPRKSSREEEIPPEKTPEAKRPSPAATKTPSMSPKVKKEPLSMSFSMSPTSRSGRVRNPTEKALQLMEQGEYVI", "function": "Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.", "AFDB_id": "AF-Q6C519-F1-model_v4" }, { "swissprot_id": "A2AKB4", "sequence": "MEELDGSLSQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPPGNPAQALTPVRHTVTLDKDVLLQNYGFHISETLPLTVVAVTAGGSAHGKLFPGDQILQMNNELAEDLSCERAADILRETEDALSITVVRCTSGVPKSSFLTEEKRARLKSNPVKVHFAEEVLVSGHSQGNSLLCMPNVLKVYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHEEELVQQVVEREESQDSRCLFRVSFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEMKCNSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGKVFNATLMLQDRESYIALLVGAKYGISQIINSKLNIISTLAEFANISRVELTEESEKVSMVKVYLQDVKVLTLLLESSSAKDLACLIAGYYRLFVDPANSVFHWSGNRRPTHRVSAEEGYESRACSDSEESSEVDCVLEPLSDRCLVKLSLCRPFAREEQPPGDSPTPEATRRGPSTCGASSMTDSAESEASDSANTESRGCRTSGSSESMDALEEDDLDACSSSGTSFFHFGPPGFSKGLETNSQEENSRVETSGFLCLLDLGQNANPQCQKIDGPQGLASEACSWGPELSMGRLDPRLYEGSRTDYYNLCSSISPGSHLSDSGSESTASRQGAAPPQWCQQGWMEAQSGSMLESLGLPALPPLAFEGGSSDEEYYDAADKLTPPDTLSGPRAADPSAMRLQSQSRTRGSEESLHPGPEGGEPSRQGGVKKYAKSLRKRRSFLQTDHTSQVSFPLEASASQENTDDVCYYDREPYLTLTAPSPTVSSLQDMQGEPGLLETKALGLLASLRETKSTNPASRIMEMEPETMETKSVIDSRVSSISAIRLRIDPSNTENPVTTDGSSASIPHSPHHSNPGSSSPQAAQVRPFPIVSPDQDPGGTTPKELTAEPEDSTFPLSSDHPNPDNPGPHHVSQGDTSELGEVRSEIGSESFLINHVQEVIPQITGPLCPGDGPTSGECEVNSEETALAADEVQGQLSLDSDREVMHRNGPSLFQKGSGKDLGDSKGDRLDNVPQALDVRAPAGEINSSLCSEPPATGTGQTSSDSEGENREAQEQELLTELDLAPDFLLPSAFPPETIKAEQLDRVIGEDSVPVSTSQQVCVHTVPSLPKLSPCQEEPRSADSGHGSPAESKGDDSPIICLPPERSFLCFAPESHPEGSTSLSRVTSFSFAGINEVAPAEIGIEHCRCQFSYATCFRGLQPETEEEDGDPQTHPAAPLTSPPSAGSQVTLPWRAARAYSCTTPLSRKSHIWPEFCSRALRQLKTTPTNAPEGFVQLTESLLELQDILEASWGVGNKHPPDKCTLHFSESRSRLCMGSQKLLASCQHVIRMDQSPEEMQGAVRVTFQHLVQLAGLCFQFTDCSRCSTRHREVAGNLRDVVYTYHQFVEAAKLTCERGYHDFSVKLLARQCTALTAAVFCLTQKFRASTAL", "function": "Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.", "AFDB_id": "AF-A2AKB4-F1-model_v4" }, { "swissprot_id": "B4G4E5", "sequence": "MHELGTRQRPLSSSSSSSSSSNMTDVSAAAGGATAPAETAATSSSASKPLTNGANKTSTAMAAPTTTPTTAATAAGAAEAGAIASVAGISNQVKLEHHHRQSNNNRPVAPYPPVPAAKPKPTPTPTAESKFKSTSREVDVALRPTPARSSTISPGVSIHTQTIQQESSSAKPGMSSSSSSAQQDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIESRKPLKRPSVTSDLFQQWMSASPTVQQKSPRSLSNSSASSTLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPHNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLNCERCSVFLVDLDCCEASHLEKIIEKPNQPEQRPTRAIMPGDSFDEKKMRNRFTVLFELGGEYQAASVSRPSKTELSTSTLAQIAQFVATTGQTVNICDVHEWVRDHNQIRAESEIDSTQAILCMPIVNAQKIVIGVAQLINKANGVPFTESDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDAIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFLQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQPRTTRTFLLLARRFLRFDLLPFRAFTRALRPLVRPLLELDVLELPDPSRIFLLTVYLRLVTRTIFLPPPEDEEEEDEVEDSVVLVVASVVVVVAVAASVVLKAELDVEALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAGCADEEIKDIEFTVTTLNCNQQAQHGAGAGGDDSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKLLESHVSEDMDDKSPTSPSQPPHAGGSVGRMSASSSTSSAGTVVDKSKKRSKLCSLL", "function": "Has a role regulating cGMP transport in Malpighian tubule principal cells.", "AFDB_id": "AF-B4G4E5-F1-model_v4" }, { "swissprot_id": "Q94A51", "sequence": "MGEIGGEELVLDVDETIFVAVAEDVERSKTTVLWAARNFSGKKICLLYVHRTARAASWTHKKLVGGSFKKHDVKVIERVEKPKVDELMNSYLQLLSETEIQTDKLCIAGQNIEECIVELIARHKIKWLVMGAASDKHYSWKMTDLKSKKAIFVCKKAPDSCHIWFLCKGYLIFTRASNDDSNNRQTMPPLVQLDSDNETRKSEKLESSYMRRRLRYWRSLLEQDGEKDTGQLEREKVEPRAPPLFSSGSSSSFGEPVGPEPVSPELVDSDTLNTSNVEEKEREGDVARKVHRYDKAMHDIGQSDRTVYGEAGKKWEEDASTTEALCKAKALEGLCIKESSQRKRLEELLEKEKLEVKMVIEQNNGFMKELQMVQGRNLKLESQMRKLQDLEKEHGEKFDTAMELLKSFRQKRDEIRIDHENAVKEVNALRRLVKGETGESSGSEMLDYSFMEINEATNEFDPSWKLGEGKYGSVYKGNLQHLQVAVKMLPSYGSLNHFEFERRVEILSRVRHPNLVTLMGACPESRSLIYQYIPNGSLEDCFSSENNVPALSWESRIRIASEICSALLFLHSNIPCIIHGNLKPSKILLDSNLVTKINDYGISQLIPIDGLDKSDPHVDPHYFVSREMTLESDIYAFGIILLQLLTRRPVSGILRDVKCALENDNISAVLDNSAGDWPVARGKKLANVAIRCCKKNPMNRPDLAVVLRFIDRMKAPEVPSSETSSYANQNVPRRPPSHYLCPIFQEVMKDPLIAADGFTYEAEAIREWLANGHDTSPMTNLKMEDCNLIPNHALHLAIQDWQNQW", "function": "Functions as an E3 ubiquitin ligase.", "AFDB_id": "AF-Q94A51-F1-model_v4" }, { "swissprot_id": "I3R9M9", "sequence": "MSRNDASQLDDGETTAESPPDDQANDAPEVGDPPGDPVDADSGVSRRTFLEGIGVASLLGIGTSAASDDSLFQMGGLKPVDDPIGNYPYRDWEDLYREKWDWDSVSRSTHSVNCTGSCSWNVYVKNGQVWREEQSGDYPRFDESLPDPNPRGCQKGACYTDYVNADQRIKHPLKRVGERGEGKWKRISWDEALTEIAEHVVDEVEAGRYDAISGFTPIPAMSPVSFASGSRLVNLLGGVSHSFYDWYSDLPPGQPITWGTQTDNAESADWYNADYIIAWGSNINVTRIPDAKYFLESGYNGTKRVGVFTDYSQTAIHTDEWLSPDSGTDTALALGMAQTIVDEGLYDEAHLKEQTDMPLLVRQDTGKFLRASDVPSVNTDADRPEWMLLMLDSNGRIREAPGSLGERDGQKDYSKSIELDFDPQLDGETTVQTQSGRVQVRTVWAELRDELANWDPEMVHEETTVGKETYQRIAREFAEADKAKIIQGKGVNDWYHNDLGNRALQLLVTLTGNLGEQGTGLDHYVGQEKIWTFHGWKTLSFPTGKVRGVPTTLWTYYHAGILDNTDPDTAAKIRESIDKGWMPVYPEERDNGSRPDPTTMFVWRGNYFNQAKGNVAVEEQLWPKLDLVVDINFRMDSTAMYSDIVLPTASHYEKHDLSMTDMHTYVHPFTPAVEPLGESKTDWQIFRELAQKIQEVATERGVEPISDRKFDREIDLQSVYDDYVRDWETGEEGALAEDRAACEYILEHSEESNPADSDEQITFADTVEQPQRLLEAGDHWTSDIEDGEAYAPWKDFVQDKNPWPTVTGRQQYYIDHDWFLELGEELPTHKEGPENTGGDYPMEYNTPHGRWAIHSTWRDSEKLLRLQRGEPLLYLHPEDAEERGIEDGDSVEVFNDLAEVELQAKIYPSSQRGTARMYFAWERFQFDSDSNFNSLVPMYMKPTQLVQYPEDSGEHLHFFPNYWGPTGVNSDVRVDVRKAGGGDE", "function": "The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. The alpha chain is the actual site of nitrate reduction.", "AFDB_id": "AF-I3R9M9-F1-model_v4" }, { "swissprot_id": "P94575", "sequence": "MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNIPTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGIYGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLLSFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGKFHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFAFASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPAYDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMMADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYDISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE", "function": "Uptake of allantoin into the cell. Allantoin uptake is not dependent on sodium, and PucI is likely to be a proton-coupled symporter. Shows highest recognition for binding of allantoin, good recognition for binding of hydantoin, L-5-benzylhydantoin and 5-hydroxyhydantoin, and to a lesser extent for a range of nucleobases and nucleosides.", "AFDB_id": "AF-P94575-F1-model_v4" }, { "swissprot_id": "Q8C208", "sequence": "MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERELSGGCAPDFLPQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLDKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTDAQALTGQPGDEIRDLEMVPDSMLHPSTERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNASGGYEKDVELVAHHGLEPGFGGSLAFVGTEHLRPLRLPPTNCISELTPVISSVYTQMQPIPSRLELPGSREAGEGPEDLGDGGPLLYRARGSLTDPGASPSNGCQDSTDTESNHEDRIGGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG", "function": "DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1.", "AFDB_id": "AF-Q8C208-F1-model_v4" }, { "swissprot_id": "Q9S1U6", "sequence": "MATLLHIDSSVFPAEASASRSVTAAFRRTWEEQHPEGTVIYRDLAAVPVPHITADAWSAGYADPSERSTRQSAAFAARLELIEELERADVILIGAPMYNYTVPSTLKAWLDSVLLLGRTAGEAPSAQGTPTVVVASRGGSYAPGTPREDFEFVQNYLEAVLRSTLGLDLEFIVPELTMAPRNPAMSELLPLFESSRERAHSEAVTKAKELTERLTADNGR", "function": "Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.", "AFDB_id": "AF-Q9S1U6-F1-model_v4" }, { "swissprot_id": "O00562", "sequence": "MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGSGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPRLYHSVKTGRGPLSDDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWTELSMADIRALEEETARMLAQRMAKCNTGSEGSEAQPPGKPSTEARSAASNTGTPDGPEAPPGPDASPDASFGKQWSSSSRSSYSSQHGGAVSPQSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSEEVFPKEMTKWNSNDFIDAFASPVEAEGTPEPGAEAAKGIEDGAQAPRDSEGLDGAGELGAEACAVHALFLILHSGNILDSGPGDANSKQADVQTLSSAFEAVTRIHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYSAFLRSPEGAGFCGQVALIGDGVGGILGFDALCHSANAGTGSRGSSRRGSMNNELLSPEFGPVRDPLADGVEGLGRGSPEPSALPPQRIPSDMASPEPEGSQNSLQAAPATTSSWEPRRASTAFCPPAASSEAPDGPSSTARLDFKVSGFFLFGSPLGLVLALRKTVMPALEAAQMRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLTVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMLVPSTPTSTSGAFWKGSELATDPPAQPAAPSTTSEVVKILERWWGTKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQLAECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRPQVLSGRFMYGPLDVVTLTGEKVDVYIMTQPLSGKWIHFGTEVTNSSGRLTFPVPPERALGIGVYPVRMVVRGDHTYAECCLTVVARGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHASSGPPRAALGKSSYGVAAPVDFLRKQSQLLRSRGPSQAEREGPGTPPTTLARGKARSISLKLDSEE", "function": "Catalyzes the transfer of phosphatidylinositol (PI) between membranes. Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.", "AFDB_id": "AF-O00562-F1-model_v4" }, { "swissprot_id": "Q02075", "sequence": "MARSTTSLFALSLVASAFARVVDYGFDVANGAVAPDGVTRNAVLVNGRFPGPLITANKGDTLKITVRNKLSDPTMRRSTTIHWHGLLQHRTAEEDGPAFVTQCPIPPQESYTYTMPLGEQTGTYWYHSHLSSQYVDGLRGPIVIYDPHDPYRNYYDVDDERTVFTLADWYHTPSEAIIATHDVLKTIPDSGTINGKGKYDPASANTNNTTLENLYTLKVKRGKRYRLRIINASAIASFRFGVQGHKCTIIEADGVLTKPIEVDAFDILAGQRYSCILKADQDPDSYWINAPITNVLNTNVQALLVYEDDKRPTHYPWKPFLTWKISNEIIQYWQHKHGSHGHKGKGHHHKVRAIGGVSGLSSRVKSRASDLSKKAVELAAALVAGEAELDKRQNEDNSTIVLDETKLIALVQPGAPGGSRPADVVVPLDFGLNFANGLWTINNVSYSPPDVPTLLKILTDKDKVDASDFTADEHTYILPKNQVVELHIKGQALGIVHPLHLHGHAFDVVQFGDNAPNYVNPPRRDVVGVTDAGVRIQFRTDNPGPWFLHCHIDWHLEEGFAMVFAEAPEDIKKGSQSVKPDGQWKKLCEKYEKLPEALQ", "function": "Lignin degradation and detoxification of lignin-derived products.", "AFDB_id": "AF-Q02075-F1-model_v4" }, { "swissprot_id": "Q588Z1", "sequence": "MGSHAWGGAVFSAATLIAFGSVVHASGTVAETAPQSGHAVPADQLDGETLYKARCAACHDNAEGRTPSREVLSKNPASFILASMRTGAMVPMAEGLTLEEMTAIARAVGKADAKTDDGIDLRRIWGNSVEGTPLDAPQCSSAPTPVDLGAANQWNGWSTEKDNGRFQRKPALDVADIPKLKLKWAFQYPGSKNGQATVIGDRLFTTSTSGAVYALNAKTGCVYWRHAAEGATRTSPVIAALPEGAPAKTALFFSDFTKAAVALDAETGKQLWKTVVDDQPALQMTGSITYWDGKIYVPISSGTEAFAQIPTWECCKFRGALVALDAATGKILWKRYTTEQEPRPFKLNKAGRQMWGPSGGAIWVTPTVDEARRLIYVGTSNSYTDVPYDNSDSVMAIDADTGAVRWTVQLLADDNYIDGCWQKGKEHANCPNPLGPDFSIGAAPIYRKMADGKEFLLVGQKSGMIYALDPANKGAKIWERQLSLGSALGGIEFGTAADDGKVYAGVSDIASQAKDRGKPGLWALDIRTGEVAWNFLNAPDTKCRWNNWWCHGAFSQAISVIPGAIFAGSYDGHFRAFDTATGKIIWDVDTGTKAVTTLSGAKAFGGVMDGAGPTIAGGMVYVHSGYAGRSSESGGRDLRGTDGNILMAFSVDGK", "function": "Catalyzes the oxidation of polyvinyl alcohol (PVA) in the polyvinyl alcohol degradation pathway.", "AFDB_id": "AF-Q588Z1-F1-model_v4" }, { "swissprot_id": "P24918", "sequence": "MLRSTLSRSAWRTGRHQAARNASRAFSATAQRPAEVELTIDGKKVSIEAGSALIQACEKAGVTIPRYCYHEKLMIAGNCRMCLVEVEKVPKPVASCAWPVQPGMVVKTNSPLTHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGGDRGRFHEVGGKRAVEDKNMGPLIKTSMNRCIQCTRCVRFANDIAGAPELGSTGRGNDLQIGTYLEKNLDSELSGNVIDLCPVGALTSKPYAFRARPWELKKTESIDVLDGLGSNIRVDTRGLEVMRILPRLNDEVNEEWINDKTRFACDGLKTQRLTIPLVRREGKFEPASWDQALTEIAHAYQTLNPQGNEFKAIAGQLTEVESLVAMKDLANRLGSENLALDMPSGHKPLAHGVDVRSNYIFNSSIVGIESADVILLVGTNPRHEAAVLNARIRKQWLRSDLEIGVVGQTWDSTFEFEHLGTDHAALQKALEGDFGKKLQSAKNPMIIVGSGVTDHGDANAFYETVGKFVDSNASNFLTEEWNGYNVLQRAASRVGAFEVGFTVPSAEIAQTKPKFVWLLGADEFNEADIPKDAFIVYQGHHGDRGAQIADIVLPGAAYTEKAGTYVNTEGRVQMTRAATGLPGAARTDWKILRAVSEYLGVRLPYDDVAQLRDRMVEISPALSSYDIIEPPSLQQLSKVQLVEQNQGATATNEPLKKVIENFYFTDAISRSSPTMARCSAAKKTGDPRTNFMAPGMEEDRPMGQIAYGA", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.", "AFDB_id": "AF-P24918-F1-model_v4" }, { "swissprot_id": "Q97B26", "sequence": "MKIKIGTRPSNLAVAQANMVASSLEAIGIDTEIVKHRSAGDIDTKNPIYSIGKTGVFVQDLNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALVSKYDLRSLPISAKVGTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELGLDAIVMAEAAIQRLGLNVEYSKLDENKFVPAPNQGIIAVVSKKEGTVRKILEEINDENTFEEMQIERSVVQQLKLGCSTPVGILSRPSGKGHKIIAQFFSMQGDDVSVFEQYLNDLSDVDSLVSYIRENIPREYGYIASEE", "function": "Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.", "AFDB_id": "AF-Q97B26-F1-model_v4" }, { "swissprot_id": "Q54U75", "sequence": "MIQILLSTFISFIIIIVSSNDIRSGENDNFNNNKMINNFLTTITTNDTIIIKETESPNDYDFSKEQIESLDKIVYFSSTMGIVGALFIIVSFFLFKAARTFATKMIFFLSLSDLFAAIFYLPYYRDSDIMCNLQGMGLVFFLSSSYLWTMCISISLFMVFFTTIFELNHWFKYFHFICWGIPLFTAIISLIFHAYGKTGSWCFISDPTSIFRLLYYLPLIVVFFINLVVFIAIRWKISQHSNSLVSRVNIIVSFYLIAFSLSQLPTIINSIQNFSDPDNPQFSLFAFQLLLQPLQGFLNCVVYGINEGFINHYVEFFEKYIFRCRCRKSRELKEIESDKTSLLVDYENSDDEEGFDGMDKLIIDDYNRV", "function": "Receptor for cAMP which may play a role in prestalk cell differentiation. May act as a negative regulator of cell growth.", "AFDB_id": "AF-Q54U75-F1-model_v4" }, { "swissprot_id": "Q9LV85", "sequence": "MEALLLPPSPEPQNQITNPANSKPNHQSGDVHKDETMMMKKKKDTNPSNLEKRKLKGKKKEIMDNDEASSSYCSTSSTSNSNSTKRVTRVVHRLRNPMRLGMARRSVGERQAEKLAKPLGFSLAAFANMVIARKNAAGQNVYVDDLVEIFATLVEESLANVYGNKLGSFATNFEQTFSSTLKILKLTNECANPHQSNNNDGGSCNLDRSTIDGCSDTELFERETSSATSAYEVMQGSATATSLMNELALFEETLQLSCVPPRSSAMALTTDERFLKEQTRANDLKTVEIGLQIRELRCKETALGLKFESNNLGKAALELDVSKAAFRAEKFKTELEDTRKEEMVTRIMDWLLVSVFSMLASMVLGVYNFSIKRIEDATSVCDQSEEKSSSWWVPKQVSSINSGFNTFICRVRVWVQIFFGVLMIIVFTYFLNKRSSGTKQTMPISFIVLFLGIFCGVSGKLCVDTLGGDGKLWLIVWEVFCLLQFVANVFTLALYGLMFGPINVTQETRSNRCNSMFPYWARRSVVYVVILFVLPVINGLLPFATFGEWRDFAMYHLHGGSDYA", "function": "May play a role in transcriptional processes. Regulates negatively the senescence and chlorotic lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars, darkness) agents, probably by controlling programmed cell death (pcd). Negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI). Promotes cell division and endoreduplication (e.g. in trichomes).", "AFDB_id": "AF-Q9LV85-F1-model_v4" }, { "swissprot_id": "P0CK98", "sequence": "MSSALLEEVGWDADFAIPVANAENKALEEQIRKKQKDILNLDNKLNKHKDVINALTEHLKNLKQEVSHNQALCKAKEKETESEVHLKALAERETGRLKQEITRLESQLTTLNEKKNAQENSIFKATQKIDELTSQLNWDQQTLEAFLQESAHKDEDTMAIIKYAKQDERKIKELTLNIEKLTLESNQKRKTLDNELTETVTSQIALDKTAESFRQAHTERQELISQWENTIEQMRKRDQDIQQCAMMLAELNQTIREKNDLIKERKDFLEREIENNKELERNIGTVERQAFRLRQQLQEEEKNQRRLQDEVEVLKGTVDRTATDVETSRSQLSSMKKDIQDKTTKVEEAQLHNAALEEKLRMVTEAVLNGEEQAAQMEQLLREQEQNIKEIDSQLLRQKELLFKKSQEVQALRDKEKNVTAEICATRTALSNLDSKLRKLDQNFLQQQMIISNQDFQIQMLERKTLHLQGKVNTEEKKALEKKVADLAASLEEKKKTAANLNKQLKKLQDDIRCIKKDTEKIGAEKTNLSTKIQEVELFIETSEKERKKSRLKKQDSMVEKGLLKMEVQRLRNLLYDRADGVLTLEKRRLQLQTAMKEREEEIRVHREMLNKQVKLTEQERQGLSAAVNEAMSKIDKQRKRYEVLSVSLAPPEGEEDKSQAYFIIKAAQEKEELQRKGDELDAKIRKTEKEIHALENTLQVVNNCNSTHRKALTKVTESSPAHQEKLKLEEQRRAAEEKYKYKRRQTQELQEDIESMSNTLEGLLQEEKVLNEGIERTQAHVLSLNKDILSQEEKINRAVKQCAKYTKEIRSGKQSTEKTFEERDIELRELRDFNKSINKMLLDAMEGNPELSSILQIHFTQAGLSLPSPSSTPSSRLSSKPSSARSSASLHRSSNLSASSSPRSQSVSSPQMKTVDLGLGLSVTSPRGSQPSSAGSSRSSSKCKSP", "function": "Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.", "AFDB_id": "AF-P0CK98-F1-model_v4" }, { "swissprot_id": "Q8RWG2", "sequence": "MHFFFVPNSSSSSPSPANTSSFSLSFLTPQIPENLCKSPTKIHIGTHGISGQSFLSHPTFSSKNTYLYAVVDRSSSGVFSPQKESANGEGEESNTEEGVLVVRRPLLENSDKESSEEEGKKYPARIDAGLSNIAKKMPIFEPERSESSSSSSAAAAARAQERPLAVNLDLSLYKAKVLARNFRYKDAEKILEKCIAYWPEDGRPYVALGKILSKQSKLAEARILYEKGCQSTQGENSYIWQCWAVLENRLGNVRRARELFDAATVADKKHVAAWHGWANLEIKQGNISKARNLLAKGLKFCGRNEYIYQTLALLEAKAGRYEQARYLFKQATICNSRSCASWLAWAQLEIQQERYPAARKLFEKAVQASPKNRFAWHVWGVFEAGVGNVERGRKLLKIGHALNPRDPVLLQSLGLLEYKHSSANLARALLRRASELDPRHQPVWIAWGWMEWKEGNTTTARELYQRALSIDANTESASRCLQAWGVLEQRAGNLSAARRLFRSSLNINSQSYVTWMTWAQLEEDQGDTERAEEIRNLYFQQRTEVVDDASWVTGFLDIIDPALDTVKRLLNFGQNNDNNRLTTTLRNMNRTKDSQSNQQPESSAGREDIETGSGFNLDVFLRSKLSLDPLKLDVNLDSKRLERFTRGRINGA", "function": "Involved, directly or indirectly, in the processing of chloroplast encoded mRNAs. Exhibits sequence-specific RNA binding and RNA remodeling activities, probably leading to the activation of translation of the target gene cluster psbB-psbT-psbH-petB-petD. Blocks 5'-3' and 3'-5' exoribonucleases (e.g. polynucleotide phosphorylase (PNPase), RNase R) in vitro. Necessary for intercistronic RNA processing of the psbH 5' untranslated region or the stabilization of 5' processed psbH RNAs. Also required for the synthesis of psbB.", "AFDB_id": "AF-Q8RWG2-F1-model_v4" }, { "swissprot_id": "G5EGM1", "sequence": "MFTGLHDILIILFLLVTLKIAQNVDHTKFLQKYGYLTSGDNQLSSESLSDALKNMQRMAGLEETGELDERTIQMMERPRCGHPDVEDHQKSRGKRYAPPQFKWKEKIITYGCKAVGTSTRISLDDLRRTMHQAASQWSELADVEIVESSVKNPMMVISAGRENHYPCTVRFDTKTLAHAFFPTNGQIHINDRVQFAMTNYTERMGANSLYSVVAHEMGHALGFSHSPDIDSVMFAYDTPRKWKFTSMDKYNMRSYYGAKASKKENEEEERKTENEDKRRKTEKDRGRTREHESDDIRPNECRVENPIVVQYRGEYLIFKSQWVWRVSSDWKRLIIKAVPINQLFPGLPNPIDAAVTVGHNLWVFVGEMIYVIYGNHMVHAPLRLSDIGINEKYVDLAYEWHYFNPPAVYIWKGSRYWKLDEKMYHRRVDERYPKDTDLNWARVPKGVHSAFTYEKEIHLLRGNQVFRMNSSRSVFDIADGYPQPLQSFFGFCPRNEKLVLNSSSSHFSLIYATITILILIF", "function": "Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium.", "AFDB_id": "AF-G5EGM1-F1-model_v4" }, { "swissprot_id": "Q4V8K3", "sequence": "MNIRNARPEDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDEDGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFSAKYVSLHVRKSNRAALHLYSNTLNFQVSEVEPKYYADGEDAYAMKRDLAQMADELRRQLVLKKSRYVVLGSEENQEAQDSTLPDAEEACQPENPAGKGSEACQPENPAGKGSEACQPENPAGKDTGSHSTDVQDSSEYLDSTS", "function": "Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.", "AFDB_id": "AF-Q4V8K3-F1-model_v4" }, { "swissprot_id": "P14690", "sequence": "MATKIFALLALHALLVSGTTAAIIPQCSLAPNAIIPQFIPPVTALGNEHLAVQAYPGQQVLSASILQQPIAQLQQQSLAHLTVQTITAQQQQQQQQQQQQQQFLSSLSALAVANQAAYLQQQLLTSNPHSLANAAAYQQQQQLQLAMANPTAYVQQQLLLSNPQAATNAATYLQQQQFQQILPALSQLRMANPTAYLQQQQLLPINQLALANTDAYLQQQQLLPVNPLVVANPLVAAFLQQQQLSSFNQISLVNPALSWQQPIIGGAIF", "function": "Major seed storage prolamin.", "AFDB_id": "AF-P14690-F1-model_v4" }, { "swissprot_id": "B3LH96", "sequence": "MSLSNKTVKELRQLLKERYTVEDELTESIALSSMRFKPSQEPEFHALSQSSLLKTKLKQQSSTDIPSYTHVLISKLSCEKITHYAVRGGNIEIMGILMGFTLKDNIVVMDCFNLPVVGTETRVNAQLESYEYMVQYIDEMYNHNDGGDGRDYKGAKLNVVGWFHSHPGYDCWLSNIDIQTQDLNQRFQDPYVAIVVDPLKSLEDKILRMGAFRTIESKSDDNSATSYYELETIIFDSELNRALFETKLNLHCVIEDDESEQISLNRLIDSMKQYSYLMDSKNVRTRIKLATTSERVSNENKKNIDYQNRSTRSQFCLNTQRGDSTETSSFGSMFSGDNTSDVDMEDRNLTQFDSTDTSLCINGEPSIHVNRVERSSRSTDNFHNSKKRMNSNQEKCHDEGNDMLQRNVLETDYARAKNRILASKIKQYERLRFYKDTFTL", "function": "Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.", "AFDB_id": "AF-B3LH96-F1-model_v4" }, { "swissprot_id": "P09859", "sequence": "MKTKVFLGLILSAAVTACLCRPAAKAPGGSHRPTSSLARRDWPEPPSQEQQQRFISRFLPHVFAELSDRKGFVQGNGAVEALHDHFYPDWMDFGRRSTEDAADAA", "function": "Potent stimulus of gastric acid, but not of pancreatic secretion.", "AFDB_id": "AF-P09859-F1-model_v4" }, { "swissprot_id": "P23936", "sequence": "MEKSKGQMKSRLSYAAGAFGNDVFYATLSTYFIMFVTTHLFNTGDPKQNSHYVLLITNIISILRILEVFIDPLIGNMIDNTNTKYGKFKPWVVGGGIISSITLLLLFTDLGGLNKTNPFLYLVLFGIIYLVMDVFYSIKDIGFWSMIPALSLDSHEREKMATFARIGSTIGANIVGVAIMPIVLFFSMTNNSGSGDKSGWFWFAFIVALIGVITSIAVGIGTREVESKIRDNNEKTSLKQVFKVLGQNDQLMWLSLGYWFYGLGINTLNALQLYYFTFILGDSGKYSILYGLNTVVGLVSVSLFPTLADKFNRKRLFYGCIAVMLGGIGIFSIAGTSLPIILTAAELFFIPQPLVFLVVFMIISDSVEYGQWKTGHRDESLTLSVRPLIDKLGGAMSNWLVSTFAVAAGMTTGASASTITTHQQFIFKLGMFAFPAATMLIGAFIVARKITLTEARHAKIVEELEHRFSVATSENEVKANVVSLVTPTTGYLVDLSSVNDEHFASGSMGKGFAIKPTDGAVFAPISGTIRQILPTRHAVGIESEDGVIVLIHVGIGTVKLNGEGFISYVEQGDRVEVGQKLLEFWSPIIEKNGLDDTVLVTVTNSEKFSAFHLEQKVGEKVEALSEVITFKKGE", "function": "Responsible for transport of beta-galactosides into the cell, with the concomitant uptake of protons (symport system), and also for transport of homologous and heterologous exchange of beta-galactosides.", "AFDB_id": "AF-P23936-F1-model_v4" }, { "swissprot_id": "Q96DN2", "sequence": "MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM", "function": "May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.", "AFDB_id": "AF-Q96DN2-F1-model_v4" }, { "swissprot_id": "Q4A6S2", "sequence": "MAFFSKFLNIKSTEMRIAEKSLKRINDLEKYVINNTDEELRSKTQFFKDLLKEGYKLEDIRDEVFAVAREATKRVLGKRPYDVQILGGILLDLGSVAEMKTGEGKTITSIAPVYLNALSGKGAIVSTVNEYLTERDAQEMGQVFNYLGLSVGINKAQMDPNLKRYAYSCDITYSVHSELGFDYLRDNMVSDMSEKVQRELNFCLIDEVDSILIDEAKTPLIISGGEANDSSSYYSADQFVRTLNNDDFLVDEESKAVTLTASGIEKANSFFRIDDLYNIEHSEKVHLIQNALRAHKVFKIDVEYIVKNNKIELVDAFTGRIMEGRSYSEGLQQAIQAKEMVEIEPETQTLATITYQNFFRMFNKLCGMTGTGKTEEQEFIDIYNMRVNVVPTNKPIAREDAPDLIFATAKDKWEAVGKEVERLYQKGQPVLVGTAQIEDSEIIHRILIEKNVPHTVLNAKQDKALEAEIIAQAGVKGAVTIATNMAGRGTDIKPSKEALELGGLYVLGTDKAESRRIDNQLRGRSGRQGDVGISRFYISLEDQLIMRFANFEAFQEVYAKDAGKEITNKQLRFAFNNAQKKIEGFNYDSRKSVLNYDDVIRQQRDLIYSQRDLLLISNEFEEIIRRMIKVFVKNLVAIEDHKLKSGAYDYQKLVDFLNKNIAVYIKHDFNVDEFKRIHDNELVDKVNQMVNDIYNQWLANAIEKTDQAYIDNFKKQVLLKTLDDNWKKHINKMDKLRSNVNLVQYSQKNPYQIYTDEGTKMFEDLIQTIAFESVLKVFSSPLGEKSLITAEIKNDPLYQQVASTFEYNPYLSISEQEKQLLERYNNVKQRLNEVEQQNLQEQSYKDPASDNLENNPEPKTGSQSQSEHEMVLTPDTVIDPSIDTNQWFEEINIDDFINVTKKDSELESKEKEQEEVKNQETQPKENKPAETKVDATKNQENVSEELKAKEVATVVEEKPKKVSKAKSEKLKVAKKVKPKDLESKEKPKSDKAKKSLAKKETQKPKKPKITSEVKIAKVEKTNKKAKAQDKPKAKVTKAKETKPKTEVKADKVKTKTAKTSEAKAQKVEAENFVNKIVFPKNKIDLKLEKIKLK", "function": "Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.", "AFDB_id": "AF-Q4A6S2-F1-model_v4" }, { "swissprot_id": "Q8INF0", "sequence": "MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVREEILFDTVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQLTAALQVHPLSPVPPTPTPKTKAIMPPVSKPLTPMMPVSVSLAASMPTSNVPAVDVMASSSSISGLALTAAAAAHMSLHHQAVVAEALTGASVEVALPSVASGATGAAAGGGAPSDDRNSRIYSPVTFKDVARRSVANSPVRSCAQPDQERRRESRSNSTGHVFMRTPSEIFGSLILDTEEFLEDLQISRSSLANNNNNQSPCGFSPTPPFRIGSAPPKPRPSNPDKFTPEELAAMDQLTPPSTAPARETASCSSASLDRDKATKLKKITFSNSSSLDATTPTALAAVVCPMRTKSPPMAVAPVMHMVQASTSKGDGQRPGSKDSVSSISLHSPPPHRSNSAPARPHSMSKAARKAFLAAKQTKAMEKLDKMIEEVQEVESQSVAKAANMRLALYGHDGGGDLAAGGCPLFLPPPPQQQQQQQQSLMPSSISDSGLCSHGHSHAPSCHHMDPKMTNSQSFQHSPRGGITHQCCSGFGHGNGRHSHRMHSNACRIL", "function": "Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.", "AFDB_id": "AF-Q8INF0-F1-model_v4" }, { "swissprot_id": "Q4P7S1", "sequence": "MPPKMRSSQENVAVSSDATIQASSASSPLQDAMAAVTSLFPLTSPFPDPAKDDTLIPAADILLEQELLRNPDNFRSWSSYIDHIINTNVVKRPPPDVSLTTYQAALLGPLASSTQRTALRRLTSIYERALAQFPTRYSLWRDYLQNRSRFVLGDPKGGSDAKRKRDLQAAREKLDFGPTLIDSVEDEDFGSAYRGGLDGTVGWQEWKSLAALYERALMWLPTMPRLWLSYLSMFIHPQCPPILSFTHARRTFDRALRTLPGSLHLRVWKVYLKWAERRGGETCLRVWRRYLRVDPSLTERYVSILLAQREDQDEPEGEEEEAEDDAQSDRSRKQSGSKALEASKLLLGLARSAMDGTYVSPEGKSPFQLFVEWLELTEKYPEEIGLDPEEEKKYLQHSVALTSDNGMTNARRAPRHIQGKGTAAREIAKASSSKHPETDALDPTRLNVTAIIQKDGLDKFSDQSGRLWTGLATYWIKRGEFDVARDTFEAGIQTVKTVRDFTQIFDAYAETSENVIAFMMDELTEEGGDEEADAEDQEETREDKEAELDRRMQEFEELIERRPLLVNDVLLRRNPDDVQEWEKRVMLYGDNDEKIIETYREAIQKINPRKATPNFHQLFLNFAQFYEYGGSAGLAKRMAEGVEGQEEEEQAEQVEGDLESARKIFEKAITIPFRRVDDLAEIWCEWAEMELRHSNYDEAIRTMARSVAPPRNTKGIQYHDDTLPPQTRLFKSLKLWSFYVDLEESLGDVESTKRVYEKMLELKIASAQIIINYAAFLEDNKYFEESFKVFERGVELFSYPVAFEIWNVYLSKFVKRYGGAKLERARDLFEQALDKCPARFCKPLMLMYGQLEEEHGLVKRAMKIYERATRAVSTDDRFDMYVFYIAKAAATFGLAATRPIYERAIESLPDRQTAEMCLRFAALERKLGEIDRARVIYAHASQFCDPRTQTDFWKEWNQFEIETGSEDTFREMLRIKRSVQAQFNTDVSYIAASALASAQQNQAQRGAQGSSNGHVREDDVDASDPMARVEAASRSAGARQTAFVAASTAASGARSADTTIGDVAKNDEVVGGDDQDDQDLL", "function": "Involved in pre-mRNA splicing and cell cycle progression.", "AFDB_id": "AF-Q4P7S1-F1-model_v4" }, { "swissprot_id": "Q820F2", "sequence": "MHEMSVALAVIDQVEQAAQQAGDVTAVRSVRLQVGELAGVVPDSLSFCFELACAGTVLEGADLVTEEVPGRARCAPCAREWSVGMPPRLSCPECGGARVDLLSGRELQIVSVHWEDGRTHAQTREPISEER", "function": "Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.", "AFDB_id": "AF-Q820F2-F1-model_v4" }, { "swissprot_id": "Q59PR9", "sequence": "MSDLKTTKDTLVSTLFELSKAAQDAANAAIEFYKVASGGSDHVSAEQLKAVSEALNTVATLSSGNGAKIEATESKKKRKQEKDPNAPKKPLTMFFQFSYDLRKKIGIERKKKDLPSLSAIDMNSMIKDRWDSISEAEKAGYKKRYDDAMIIYNIEKKKYEESLKDGSAYYPPPSVQTPIVGHGIEQDFDDDATDIVSSPEEPKKKKKKTEKKEKKKKSGHGSP", "function": "Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth.", "AFDB_id": "AF-Q59PR9-F1-model_v4" }, { "swissprot_id": "O24296", "sequence": "MASMAFSTTFFTPLRDFNQPRTNSTPSTSLPFTKSSIASSKSPFFQLGFSQQASSNFPIVPSKTRSFSVNAKAIKDKTIYDFTVKDIDKKDVSLSKFKGKVLLIVNVASRCGLTSSNYTELSHLYENFKNKGLEVLAFPCNQFGMQEPGSNEEIKQFACTKFKAEFPIFDKVDVNGPFTAPVYQFLKSSSGGFFGDIVKWNFEKFLVDKNGKVVERYPPTTSPFQIEKDIQKLLAA", "function": "Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.", "AFDB_id": "AF-O24296-F1-model_v4" }, { "swissprot_id": "Q9YGT0", "sequence": "MGEHNLFNPGFVGQLVNINARDAFYLSNFRASGGQLAGLQTLRLSRRDNVCSLPWNPSEACSGYPQSHISGPVTLNHTYNQSCDITRQEDNKCFYSDSACATSGGGDNNSTNLISKEGALDNSSVSITAENGQNNLNGMDNGGSYSKYDCLTPAEQPIPNPRLCRSLESVSGCSFINEGAKTSSGITHSLTSPDIQTSVAALNGGALWYPMHRQTRKKRKPYSKLQLNELEGEFILNEFITRQRRRELSDRLNLTDQQVKIWFQNRRMKKKRLLMREQALSYF", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.", "AFDB_id": "AF-Q9YGT0-F1-model_v4" }, { "swissprot_id": "Q03W48", "sequence": "MSLNVVMGNGQHDLRSEMLTMIQQQFCQNELLTVFYIVPNHVKFDSEVNVLQRFSIMNGNDDSELYAQSRLQVYSLTRLAWALMKNTPDRQPDIVEPTGLFMIVSNILREQSDNLPVFSRMQTKSGFVSALVAQLVELRASNVTPENLLEVLEKSADNIFLRQTLNAKLHDLAIVADDFNARMGENQITGQETLIAFAKQLADLKLSNVAFYFDGFNGFTSAEMMVVNQLITTYPVTMGILGDPEKMGQQREGDVFFKPMTTVEQLSITARTAQQEVAITAATKMRPLSRTAQQVLGAWACLGEYRNFTGSRDEVHLNVFAAENPITEIKEVARRIRRSLVDDPTLHLRDIIILSRDLTPYQAHIEAVMSQFELPYFLDMDVNMMNHPLVELILNLLAPNKFQYQTMLAILKTGLLRPTFENKIVSHDEFFDIVSHMDNYLYAYRPYESRWRDFSRPFKLFQVTRDDDDTEISEDEKVNNRLEYLRHFIVEAFDELDDGFAMAKNLRQSVTHLVLWLQKYHVTDALLEQRDDFIAQGNLSRSQQSEEVWQMLTKTLDEMVEIDGERSVSLTDIVTTLQAGLSGAKFSGIPNNLDQLMISEAGIVQNTQYKQLYFIGGTRQNLPAQVKNAALINDAERSIVQPALQSGTNPRYLQNTAQQQMAEENLLFYGSLMSSIGSITLSYPILEPSGQLAEMSPFFKRLVDTFNSEVEVIGSIPSSAASLLKQYVGTARATLSDLVKILPVYGQTAAFKAVQNVISNTMQDRLERVLSAPNYQNNTTKLKPEFISALFGERLNVSISQLESYYSNPFAYFLQYGLKLQERATNELNVAQTGTLYHAVFENVLHELIVKNKSLRDITGDELRALVRQHMQSQLALPAFEILNDSGKMRATTNYLTRVCETLVLNLQAAARENTSKPEAVEQLFGFSKESLPPLSFARMQVRGKLDRFDKQDVNGEFGTIIDYKSNGKTFNWGQAYDGLQMQLLTYWDAAQQSAEKLGVAAIGGAFFAKISPEKTKITDKTDLNALFTGKLIPETFKYRGLFISEPAYVSALTTLEPQEKSAHYPVVLLKNGALGKIGVDAVDPDEFALLLQRNRENIITAGDLILSGYFPIMPVEGGLTYSPYLDIIRFDRALGDAYKVQSPADKNTIIKLLKGGQD", "function": "The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.", "AFDB_id": "AF-Q03W48-F1-model_v4" }, { "swissprot_id": "A2SQJ8", "sequence": "MKICIVSRIDLKEPVELAQSLGWMLRDQGHDVVYEQSVAAELGYAPVSLSKDFSADLIVVLGGDGSVLRTIRMLDHQVPVVGINQGQVGFLTDIERDKAEEILTSLSLPLPLDPRMRISIEFNGRSVGSALNEAVIVTSRPAKILKFAVFVNGRQIDEFRADGLIIGTPTGSTAYAMSAGGPIVDSTIEAMLLVPLAPYMLSSRPYLINSNSEVEIRLVSVKPALLVIDGQDQYEIGENATLLIRKSPDPALFVDVGRGFFDKVEQKLRLL", "function": "Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.", "AFDB_id": "AF-A2SQJ8-F1-model_v4" }, { "swissprot_id": "B1XMM7", "sequence": "MPCPGLQENVTIYKLSIDICRSSRSSSPMNLLATSPSASTAFFQRSAGRWHSQRRYYTLNSDQEPLEAISAIEVVFLPAEHPHLKPLAIAHHLSPDQAFQCGAKVTWESTYTNVQRKPLKGETIFGIRDQLMYRDRGFSTTAPIVAEFELIQPHVMRLQTAYDGASFEEEIKFVGDKHRTRQTITSRAGQELMIAQYLETRL", "function": "Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.", "AFDB_id": "AF-B1XMM7-F1-model_v4" }, { "swissprot_id": "O59679", "sequence": "MSNPRMFQSRGKRVVSDSLPIANSTHTLEDTLKLRPDWTIALSQHETETRSTRTSCSTTTESTIAMRSKQKAIISVLEEFRDSEAAYVHDLHVAQRYYADRLSDRVKKSEWKDVFEIFLVLCKQASLFEIEMHKSLNDEINYILDDQDACLKPKPSVAQLFLSWLPKLSAVYGRYCVIQENIGKKVEKWMKNSSISEYLQECDSMAKIESNSWNLDSFLVKPVQRFLKYPLLLNQLYRSASLGIISDYVLLGEACHKSEIASQRMNELKRRRDIIITALDSVSNSQEVLLLSTDSIDKKIAKLQNSTNIFYVPEHEPILAFVHQLSSSYTNLLNLRSAICDWLKFSRYHYLKFFTFVEAYSVFCKDTKSADKWALISVALDNIAKGAVLRLTEQCQTSVLRPISNGILFFRNPLCVTDVWIKKATAFSKRRQSQVFEEDLESFPLLSNCLLEELPLFLEMARNVTDECILAFAQIQATFYDTIQKVLEPVVAKFNLTDHQDIPSIESIMDFTSLRSSMESSPKSK", "function": "Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation.", "AFDB_id": "AF-O59679-F1-model_v4" }, { "swissprot_id": "P43131", "sequence": "MKTIRTGMMTLAALAVLGTNVVSATSEPVKELSVNVNGQHIEQAAIFDKGQQTVLVPLRDVAESLGFQVKWNAETKAAEVNKGAIFSYAKVGEDRYPFAKMYKTLGAEPRLLNGNTYVPVAFVDEILQAEVNVTDDAVTVVDEESDVAPVRTGTITTLNKREDGGVSFQLNGYETGIILHVDKETKITTADGKELKPEDLQLGMEVEATHQKFMAMSMPQSGAVSIVVKSGLETPEVLGTAGKVASIDKDQEGSYKMLVEGQALAENAPEKVALIVGKDTKIVSAKDNKELAPEDLKAEMKVFAYYGPKLTRSLPPIGVAEKIVVE", "function": "Shows inhibitory activity towards serine proteases, such as trypsin, chymotrypsin and subtilisin. May form a trypsin-inhibitor complex in a molar ratio of 1:1.", "AFDB_id": "AF-P43131-F1-model_v4" }, { "swissprot_id": "O13113", "sequence": "MSGTAGSGVGAAGSVGSVVRRFLAEYGSGTSSRLKVLDAYLLYVMLTGALQFGYCLGVGTFPFNSFLSGFISAVGSFILGVCLRIQINPQNKGEFQGISPERAFADFLFANTILHLVVINFVG", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.", "AFDB_id": "AF-O13113-F1-model_v4" }, { "swissprot_id": "Q47XJ9", "sequence": "MKKLDKTNNSNKLSYQKDGTPYCQRFDDIYFESESGYQQSDFVFIQKNKIGLRLQIAKQTFTVAETGFGTGLNFLLTLQAYQKAQQVSSFQLAPLHFISVEKYPLTKEQLVQSLSILPQLQSLALTFINSYPDCPVEEFGQEFKTTFFNGQVRLTLIFDDAAQGFSSLNCSKEGLVDAWYLDGFTPAKNPDMWSKDLFSQIGRLSKDQATLTTFTVAGFVKRQLRDIGFRLEKLLAKGKKKEMLSAVMQSNPITNKGYYLRPLITKPQHVSIIGGGIASACAAYALTKQGVKVTLYCKDTSLAQGGSSNAIGALYPLLHQQEDDISSFYQQAFWRAKALYTEIAEQGFSFAHQWCGLLEVSYKEALIKRQQAFESLNTWPNELIHGVNAKQASELANIDLPYGGLFMPNAGWMSPRDLVKQIFNAAKSTTRLKIMTDTHITKIQQVANPSSNENGTSWSLTSNQGEFNASVLVICGGADAIEIEQLKSLPLTATRGQVTSMKSNKKINKLSTVICHKGYLTPENNGIHCIGATFQKNDTNITTNKADDDYNLTMLTKCLPELSSTIDWQEQDISSSKARLRCMSQDHLPLVGAVPDIKEHVATYSHLAKDKNWKYSQAAPCIDNLYVLLGLGARGLCSAPLAADILTAELCNTPYPVDSQMLFNLSPNRFIIRDIIKRKIKS", "function": "Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.", "AFDB_id": "AF-Q47XJ9-F1-model_v4" }, { "swissprot_id": "Q02LX5", "sequence": "MTHDLAASGLRFGIEEEFFLLDASDLDIVRSAPAGFVAACRDTLGEHFAEEMFECQVEVASPVFSTLAEAARFHGQARQRLAHLAMDFGLRSLCVGTHPFADWRRARSNPAAHFARLFEDQGRVARRSLVCGLHVHVEIPPSHDRMAVLQRVLPWLPLLLALSASSPFRGGRRSGLASYRRALCGEWPRMNIPPALPDEDAYRRHLALLREAGCIREDGQVWWMIRPSSHVPTLELRICDACPRLADALSLAGLFRALVGEALGAGPRTLPVARDACLEENYWQALRYGCAGRYLVGGRAVGAGDWLEMAWRQCRPQARQGNEWAYEHARGLLGETSASRQLRRYQTLRAAGQERHVALRRLVEELLEENLQPALAGPAGKRAHEGGRSFRPAAGAPMSIRGQE", "function": "ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.", "AFDB_id": "AF-Q02LX5-F1-model_v4" }, { "swissprot_id": "A6SSW9", "sequence": "MTKIWFITGSSRGLGLAIAEAALNNGDSVIATARKPEQLTNLVNKFGKERVFPVALDVTDNNQVLQAVKSGHEKFGRIDVVINNAGYANTAAVEDIDVDDFCAQVEANLMGVVYVSKAVLPILRQQKSGHIFQVSSLGGRIGAPGLSAYQSAKWAVGGFSTVLAQEVASFGIKITVLEPGGIRTDWAGSSMQVPTVSEPYQATVGAFAESLRKSSGSEVSIPSKIANIVLKVLGEKEPPLRLLVGPDAVEYAGKAAEVLSASDEKWRELSLASA", "function": "Oxidoreductase; part of the gene cluster B that mediates the biosynthesis of botcinic acid and its botcinin derivatives, acetate-derived polyketides that contribute to virulence when combined with the sesquiterpene botrydial. Botcinic acid and its derivatives have been shown to induce chlorosis and necrosis during host plant infection, but also have antifungal activities. Two polyketide synthases, BOA6 and BOA9, are involved in the biosynthesis of botcinins. BOA6 mediates the formation of the per-methylated tetraketide core by condensation of four units of malonyl-CoA with one unit of acetyl-CoA, which would be methylated in activated methylene groups to yield a bicyclic acid intermediate that could then either be converted to botrylactone derivatives or lose the starter acetate unit through a retro-Claisen type C-C bond cleavage to yield botcinin derivatives. The second polyketide synthase, BOA9, is probably required for the biosynthesis of the tetraketide side chain of botcinins (Probable). The methyltransferase (MT) domain within BOA6 is probably responsible for the incorporation of four methyl groups (Probable). The trans-enoyl reductase BOA5 might take over the enoyl reductase function of BOA6 that misses an ER domain (Probable). The monooxygenases BOA2, BOA3 and BOA4 might be involved in further hydroxylations at C4, C5 and C8, whereas BOA7, close to BOA9, could potentially be involved in the hydroxylation at C4 in the side chain of botcinins (Probable).", "AFDB_id": "AF-A6SSW9-F1-model_v4" }, { "swissprot_id": "D0ZWT5", "sequence": "MKVHRIVFLTVLTFFLTACDVDLYRSLPEDEANQMLALLMQHHIDAEKKQEEDGVTLRVEQSQFINAVELLRLNGYPHRQFTTADKMFPANQLVVSPQEEQQKINFLKEQRIEGMLSQMEGVINAKVTIALPTYDEGSNASPSSVAVFIKYSPQVNMEAFRVKIKDLIEMSIPGLQYSKISILMQPAEFRMVADVPARQTFWIMDVINANKGKVVKWLMKYPYPLMLSLTGLLLGVGILIGYFCLRRRF", "function": "Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB exotoxin.", "AFDB_id": "AF-D0ZWT5-F1-model_v4" }, { "swissprot_id": "A9V2Y9", "sequence": "MANSTDETATTTLAPAPCFLFDIEGTTTSISFVHEVLFPYARNQVEAFLAAHWDTDAVKADVDKLREQVSGCGKRSVADEAGPKEHGAEAASRLCASRPILLNLLEKIILTWPLVPTAHPLLELGHIWKDAYTSGNVKGHIYEDVVPAFQRLTEAGAQLYIYSSGSIAAQKLLFGHSEAGDLQPYLSGYFDTTTGPKRDAASYSDIAAAIGVTPQSIIFLSDRIEECRAASAAAMRTALVVRPGNAPLSEAERTEFPILHDFTGLRGAKFTQAQAGDTEAKRSASGDGALAAKKAPPTHDF", "function": "Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).", "AFDB_id": "AF-A9V2Y9-F1-model_v4" }, { "swissprot_id": "Q1PEP5", "sequence": "MGKSSKKSVTEVETPASMTKPLKKGKRDAEEDLDMQVTKKQKKELIDVVQKEKAEKTVPKKVESSSSDASDSDEEEKTKETPSKLKDESSSEEEDDSSSDEEIAPAKKRPEPIKKAKVESSSSDDDSTSDEETAPVKKQPAVLEKAKVESSSSDDDSSSDEETVPVKKQPAVLEKAKIESSSSDDDSSSDEETVPMKKQTAVLEKAKAESSSSDDGSSSDEEPTPAKKEPIVVKKDSSDESSSDEETPVVKKKPTTVVKDAKAESSSSEEESSSDDEPTPAKKPTVVKNAKPAAKDSSSSEEDSDEEESDDEKPPTKKAKVSSKTSKQESSSDESSDESDKEESKDEKVTPKKKDSDVEMVDAEQKSNAKQPKTPTNQTQGGSKTLFAGNLSYQIARSDIENFFKEAGEVVDVRLSSFDDGSFKGYGHIEFASPEEAQKALEMNGKLLLGRDVRLDLANERGTPRNSNPGRKGEGSQSRTIYVRGFSSSLGEDEIKKELRSHFSKCGEVTRVHVPTDRETGASRGFAYIDLTSGFDEALQLSGSEIGGGNIHVEESRPRDSDEGRSSNRAPARGAPRGRHSDRAPRGGRFSDRAPRGRHSDRGAPRGRFSTRGRGPSKPSVMESSKGTKTVFNDEE", "function": "Involved in pre-rRNA processing and ribosome assembly.", "AFDB_id": "AF-Q1PEP5-F1-model_v4" }, { "swissprot_id": "O88987", "sequence": "MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKMDTSTDPVRVLSWLRKDLEKSTAGFQDSRFKPGESSFVEEVAYPVDQRKGFCVDYYNTTNKGSPGRLHFEMSHKENPSQGLISHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIHGAENKCVHQSLYMGDEPTPHKSLSTVASELVNETVTACSKNISSDKAPGSGDRASGSSQAPGLRYTSTLKIKESTKEGKCPDDKPGTKKSFFYKEVFESRNAGDAKEGGRSLPGDQKLFRTSPDNRPDDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLMKHAKEVVSDLIDSFMKNLHGVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYNVMFAKKFPENIRRARDKSESYSLISTKSRAGDPKLSNLNFAMKSESKLKENLFSTCKLEKEKTCAETLGEHIIKEGLHMWHKSQQKSPGLERAAKLGNAPQEVSFECPDPCEANPPHQPQPPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQSFLEAAASTNFPTNKPPPPSPVVQDECKLKSPPHKICDQEQTEKKDLMSVIFNFIRNLLSETIFKSSRNCESNVHEQNTQEEEIHPCERPKTPCERPITPPAPKFCEDEEATGGALSGLTKMVANQLDNCMNGQMVEHLMDSVMKLCLIIAKSCDSPLSELGEEKCGDASRPNSAFPDNLYECLPVKGTGTAEALLQNAYLTIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSATAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL", "function": "May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.", "AFDB_id": "AF-O88987-F1-model_v4" }, { "swissprot_id": "P19642", "sequence": "MTAKTAPKVTLWEFFQQLGKTFMLPVALLSFCGIMLGIGSSLSSHDVITLIPVLGNPVLQAIFTWMSKIGSFAFSFLPVMFCIAIPLGLARENKGVAAFAGFIGYAVMNLAVNFWLTNKGILPTTDAAVLKANNIQSILGIQSIDTGILGAVIAGIIVWMLHERFHNIRLPDALAFFGGTRFVPIISSLVMGLVGLVIPLVWPIFAMGISGLGHMINSAGDFGPMLFGTGERLLLPFGLHHILVALIRFTDAGGTQEVCGQTVSGALTIFQAQLSCPTTHGFSESATRFLSQGKMPAFLGGLPGAALAMYHCARPENRHKIKGLLISGLIACVVGGTTEPLEFLFLFVAPVLYVIHALLTGLGFTVMSVLGVTIGNTDGNIIDFVVFGILHGLSTKWYMVPVVAAIWFVVYYVIFRFAITRFNLKTPGRDSEVASSIEKAVAGAPGKSGYNVPAILEALGGADNIVSLDNCITRLRLSVKDMSLVNVQALKDNRAIGVVQLNQHNLQVVIGPQVQSVKDEMAGLMHTVQA", "function": "The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport. MalX can also recognize and transport glucose even though this sugar may not represent the natural substrate of the system.", "AFDB_id": "AF-P19642-F1-model_v4" }, { "swissprot_id": "O13862", "sequence": "MSEHSPEASSTYAQVTSNDELSSNKIYMNADQNNSRKKEMDGSLQNNGGRLQNVNPLGGNESMSAVATSAASSLPTAENGVSLNAASPTIHSNTPTVVSHPVMSGSELKGEESHNSPGTLNGTSVANASKQPNMPNATFRCDKCDMMFVKQSGLTNHKRTYHQVETVVIIGHRRYVWRRNENGRFQCVCGRQNWRRPVNFASHAKQCPSFLAMDPNNIPPEINKVSPHDDLRPLSDSRRRARRPHPSDTIPPGASMARSDPSQVPESNPSAAAAVAAAAVAAAANLTNGVNPPEVPRNLNSSLVDAAESLANVSQQQHHRHPFARQPDYSAHSIPRTAAPYAPSMNMFAQNGPNTSLLPTAMPSDVSISSSLQQQPIHPSYDSRFSKAPQGTDALAALGYGTPSSAATLCPLYRDTPAAIVSEKLHLRLANLRIAYCEDCREFISLNAALDHRRSHHQQNITGDLVHVYSDFLDFQNC", "function": "Acts as a DNA damage-response activator of rhp51. Binds to part of the DNA damage-responsive element (DRE), (5'-NG[GT]T[GA]-3').", "AFDB_id": "AF-O13862-F1-model_v4" }, { "swissprot_id": "E2JA32", "sequence": "MNKGENMNLEMWVQNISATFPWYAQLLRDKQADLSRLESLPLITEELLTQHYYHAENSFPGEHHSYLTSGTTSGKRKRIFYSDNDQRIYLQQRMDIIRDFCGEGHTRACADLGTGHAAATAGEIFQAMGCDVELIDFTRPIEQHIEVLNRFKPDIFFTMPMILDSLIATGKLDFQPKRIILLGDVASLNWQNKVADYFHIQPAQVLDLFGSIEIGSIAFYNHAQKRYQFDSYVRPEVVPVQSLYPGAKYGGDGGILLLTSFAREYFPAVRFVTNDLIEGFAQENVGGRTVYTYQRCLGRFAGEFKHGEKINLSDISDALANNLPYHKYDLADHEGGLVIRIAAKSIPTEVIEAIKHDLLARNPDIAQMISSGLVGDIRIQCVDAQEITGNVSKRRY", "function": "Involved in dapdiamide antibiotics biosynthesis. Ligates fumarate and 2,3-diaminopropionate (DAP) to form N-beta-fumaroyl-DAP. Can also form N-succinoyl-DAP from succinate and DAP, with lower efficiency.", "AFDB_id": "AF-E2JA32-F1-model_v4" }, { "swissprot_id": "P12019", "sequence": "MALNKKLISLLLLIFIILNIVNSHQQEDCDDDDEDIGISAERSERRSVKNSNDGSNFYNLNDYYTPENWNYYSGSFATKDCRDASYITIPLGTTGGLDEGNLSSFLLTKKGSNLFIALDAGTVWQGVRRLTTFKYFNTLFNITYPSWAVLPEQRTSWFLKNHVMSYFIGHSHLDHVGGLILVSPEDYLAKNWIDVQPPINNGIMGLIRKLGFKPTDFTSSSILQKKTIMGLPSTINSISTNLFNNQVWPNLPSFGRYQYFSLASGIEYPFTELVPYNATTMSLVANEFPFSVKVKPFELCHDNLISTSFLFTDSISGEQIAFFSDTGVPSSVACDWEGKIYAVWKQIKIDKLKAIYIETSFPNNTPDSAMFGHLRPRDVMKLMDQLLVQSIQTSPPMTNLKHVKLIIEHIKPQVAEDPNGWTTQRVIYQQLKEANNNGVRIIIPNQGDPICI", "function": "Phosphodiesterase which displays a preference for cAMP over cGMP. Involved in the degradation of extracellular cAMP. Maintains the responsiveness of cells to the chemoattractant cAMP during the aggregation phase of development.", "AFDB_id": "AF-P12019-F1-model_v4" }, { "swissprot_id": "Q7Y220", "sequence": "MAFNTAMASTSPAAANDVLREHIGLRRSLSGQDLVLKGGGIRRSSSDNHLCCRSGNNNNRILAVSVRPGMKTSRSVGVFSFQISSSIIPSPIKTLLFETDTSQDEQESDEIEIETEPNLDGAKKANWVERLLEIRRQWKREQKTESGNSDVAEESVDVTCGCEEEEGCIANYGSVNGDWGRESFSRLLVKVSWSEAKKLSQLAYLCNLAYTIPEIKGEDLRRNYGLKFVTSSLEKKAKAAILREKLEQDPTHVPVITSPDLESEKQSQRSASSSASAYKIAASAASYIHSCKEYDLSEPIYKSAAAAQAAASTMTAVVAAGEEEKLEAARELQSLQSSPCEWFVCDDPNTYTRCFVIQGSDSLASWKANLFFEPTKFEDTDVLVHRGIYEAAKGIYEQFLPEITEHLSRHGDRAKFQFTGHSLGGSLSLIVNLMLISRGLVSSEAMKSVVTFGSPFVFCGGEKILAELGLDESHVHCVMMHRDIVPRAFSCNYPDHVALVLKRLNGSFRTHPCLNKNKLLYSPMGKVYILQPSESVSPTHPWLPPGNALYILENSNEGYSPTALRAFLNRPHPLETLSQRAAYGSEGSVLRDHDSKNYVKAVNGVLRQHTKLIVRKARIQRRSVWPVLTSAGRGLNESLTTAEEIMTRV", "function": "Sn-1-specific phospholipase A1 involved in seed oil biosynthesis. Hydrolyzes polyunsaturated acyl groups from a unique chloroplast-specific phosphatidylglycerol (PG) that contains 16:1 delta 3-trans as its second acyl group. The polyunsaturated acyl groups released by PLIP1 are exported from the chloroplast, reincorporated into phosphatidylcholine (PC), and ultimately enter seed triacylglycerol (TAG). In vitro, possesses broad substrate specificity. Can hydrolyze the galactolipid monogalactosyldiacylglycerol (MGDG), and the phoshpolipids phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidylserine (PS) phosphatidylglycerol (PG) and phosphatidylinositol (PI).", "AFDB_id": "AF-Q7Y220-F1-model_v4" }, { "swissprot_id": "Q5TGS1", "sequence": "MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVPRGAEQPSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGLGQEAPALFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPPQPASSRCAESPGLGLRVWRPWGSPGDDLN", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription.", "AFDB_id": "AF-Q5TGS1-F1-model_v4" }, { "swissprot_id": "Q4QIU7", "sequence": "MASQSPKCLMLYSTTDGHTKTIMDTIARQLADETKVRCDVVDIKDGNSYVLADYEKVLLGASIRYGHFSAAFINYVKQHHSELSAMPSAFFSVNLTARKLDKNTATTNVYTRKFLNQSSWSPQLVGVFAGALWYPRYNFFDRVLIQFIMKVTGGETDSTKEIVYTDWAAVRRFASDFAALPLAVPPRPKANTVEKPDGILRSGSGAHCLLAIVGMSAAVIVGIRIIAAKRG", "function": "In E.coli extracts under anerobic conditions catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX, transferring electrons to fumarate reductase, presumably via menaquinone. In vitro under aerobic conditions forms protoporphyrin IX using ubiquinone as an electron acceptor. Complements an E.coli hemG deletion, allowing normal growth in vivo.", "AFDB_id": "AF-Q4QIU7-F1-model_v4" }, { "swissprot_id": "P53705", "sequence": "MQTSISTTTIEDHLHHYSPEESQKLLSRESSINTDLFKHENESVDLLLKEMNSTPSKLLPIDKHSHLQLQPQSSSASIFNSPTKPLNFPRTNSKPSLDPNSSSDTYTSEQDQEKGKEEKKDTAFQTSFDRNFDLDNSIDIQQTIQHQQQQPQQQQQLPQTDNNLIDEFSFQTPMTSTLDLTKQNPTVDKINENHAPTYINTSPNKSIMKKATPKASPKKVAFTATNPEIHHYPDNRVEEEDQSQQKEDSVEPPSIQHQWKDPSQFNYSDEDTNASVPPTPPLHTTKPTFAQLLNKNNEVNSEPEALTDMKLKHENFSNLSLDEKVNLYLSPTNNNNSKNVSDMDSHLQNLQDASKNKTNENIHNLSFALKAPKNDIENPLNSLTNADISLRSSGSSQSSLQSLRDDNRVLESTPGSPKKVNPGLSLNDGIKGFSDEVVESLLPRDLSRDKLETTKENDAPEHNNENFIDAKSTNTNKGQLLVSSDDHLDSFDRSYNHTEQSILNLLNSASQSQISLNALEKQKQIQEQEQTQAAEPEEETSFSDNIKVKQEPKSNLEFVKVTIKKEPVSATEIKAPKREFSSRILRIKNEDEIAEPADIHPKKENEANSHVEDTDALLKKALNDDEESDTTQNSTKMSIRFHIDSDWKLEDSNDGDREDNDDISRFEKSDILNDVSQTSDIIGDKYGNSSSEITTKTLAPPRSDNNDKENSKSFEDPANNESSQQQLEVPHTKEDDSILANSSNIAPPEELTLPVVEANDYSSFNDVTKTFDAYSSFEESLSREHETDSKPINFISIWHKQEKQKKHQIHKVPTKQIIASYQQYKNEQESRVTSDKVKIPNAIQSKKFKEVNVMSRRVVSPDMDDLNVSQFLPELSEDSGFKDLNFANYSNNTNRPRSFTPLSTKNVLSNIDNDPNVVEPPEPKSYAEIRNARRLSANKAAPNQAPPLPPQRQPSSTRSNSNKRVSRFRVPTFEIRRTSSALAPCDMYNDIFDDFGAGSKPTIKAEGMKTLPSMDKDDVKRILNAKKGVTQDEYINAKLVDQKPKKNSIVTDPEDRYEELQQTASIHNATIDSSIYGRPDSISTDMLPYLSDELKKPPTALLSADRLFMEQEVHPLRSNSVLVHPGAGAATNSSMLPEPDFELINSPTRNVSNNSDNVAISGNASTISFNQLDMNFDDQATIGQKIQEQPASKSANTVRGDDDGLASAPETPRTPTKKESISSKPAKLSSASPRKSPIKIGSPVRVIKKNGSIAGIEPIPKATHKPKKSFQGNEISNHKVRDGGISPSSGSEHQQHNPSMVSVPSQYTDATSTVPDENKDVQHKPREKQKQKHHHRHHHHKQKTDIPGVVDDEIPDVGLQERGKLFFRVLGIKNINLPDINTHKGRFTLTLDNGVHCVTTPEYNMDDHNVAIGKEFELTVADSLEFILTLKASYEKPRGTLVEVTEKKVVKSRNRLSRLFGSKDIITTTKFVPTEVKDTWANKFAPDGSFARCYIDLQQFEDQITGKALQFDLNCFNEWETMSNGNQPMKRGKPYKIAQLEVKMLYVPRSDPREILPTSIRSAYESINELNNEQNNYFEGYLHQEGGDCPIFKKRFFKLMGTSLLAHSEISHKTRAKINLSKVVDLIYVDKENIDRSNHRNFSDVLLLDHAFKIKFANGELIDFCAPNKHEMKIWIQNLQEIIYRNRFRRQPWVNLMLQQQQQQQSSQQ", "function": "Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis.", "AFDB_id": "AF-P53705-F1-model_v4" }, { "swissprot_id": "Q2GHU0", "sequence": "MSDNGDNNTKSPQHNNPQPNEKSDGKVQPGQPQVNPQRKFTAGINKKKEKLNEDLSELDKLRQQLIHFQNQFRLAVADKENVKRIMQKNIDDTSIYAISNFARDLLSSCDNLETSLKNLKEGDSIHAGVLMTYKELLNTLERHNITRIDPIGEKFNPQFHKAVSQMVDAEKDDNTILHVVQPGYIIKDKLLRAASVIISKKSD", "function": "Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.", "AFDB_id": "AF-Q2GHU0-F1-model_v4" }, { "swissprot_id": "A5CAL1", "sequence": "MESIGVLLTCPMNPYLEQELDKRFKLFRFWDFPSANDLFREHSNSIRAVVGNSFIGADAQMIEALPKMEIVSSFSVGLDKIDLVRCKEKGIRVTNTPDVLTEDVADLALALILATLRRICESDRYVRSGSWKKGDFKLTTKFTGKSVGIIGLGRIGSAIAKRAEGFSCPISYHSRTEKPGTNYKYYPSVVELASNCQILVVACALTPETRHIINREVINALGPKGVVINIGRGLHVDEPELVSALVEGRLGGAGLDVFENEPNVPEELLAMDNVVLLPHVGSGTVETRKDMADLVLGNLEAHFLNKPLLTPVV", "function": "Involved in the biosynthesis of L-tartarate from L-ascorbate. Catalyzes the NAD(P)H-dependent reduction of 2-dehydro-L-idonate (2-keto-L-gulonate) to L-idonate. Can also reduce hydroxypyruvate to glycerate, glyoxylate to glycolate and pyruvate to D-lactate. Prefers NADPH to NADH as proton donor.", "AFDB_id": "AF-A5CAL1-F1-model_v4" }, { "swissprot_id": "P38769", "sequence": "MCSPTNFLYEPFSSDAVTQNYDQNLKCTKCGAYYSMACSLREQNVWTCLFCNQSNSNAELPLVPSNTYTLTSAKKEILSRRTIMIIDAICDPHELNYLVSILCNNYITRQQEPLSIITIQQSGHVILHNAVNHRRDAVFSINEFMTKYNLDKLNASYFEKKISEINQESYWFDKSTQGSLRKLLREICKIANKVNISSKRDKRCTGLALFVSSVLASQCSLSAYCHIVSFLNGPCTKGGGKVMSRERGESMRQNHHFESKSSQLQLSKSPTKFYKKMLEKFANQSLIYEFFIASLDQIGILEMSPLITSSMAVSQFDSFNDERFAMSFQKYLNLRDHNAIYNCHSKIMTAKNAIVVKDFPKYSLNPKNLSLPLEISLGHNSAEAPIQFQTTFENQTEKYIRIETLLLPKANRSFGAQNEIVFSMKKIASRIIDSFAYSSKHTKELMKQLFLLPNQIRGKDVDMVNLIQWCYHIYRSPILSVRNTSPDERYLFLHRIINASKDTCLSLCKPFIWSYSDLKHDWIVLDVPLTRAQILQDDKTTICVDGGSYLVLRRGKLLEKEGRELCCKLLNDLQRFPQPLYVETKTGGSQDRFLKSKIIPLDITDKETLGTEDMTFNEYFNLFTDLSGSK", "function": "Acts as a GTPase-activating protein (GAP) for SAR1. Contrary to its SEC23 homolog, NEL1 does not associate with SEC24 and its homologs, nor does it associate with the COPII components, suggesting that it is unlikely that NEL1 functions as a structural component of the vesicle coat machinery. May function as a signaling molecule.", "AFDB_id": "AF-P38769-F1-model_v4" }, { "swissprot_id": "Q5RCY5", "sequence": "MGIRGLMSFVEDHSNEFFTDLKLRDTKIVIDGYALFHRLCFSSNLDLRYGGDYDSFADVVQKFFESLFACNICPYVVLDGGCDISDKKLTTLKDRAREKIQMAHSLSVGGSGYVCPLLIREVFIQVLIKLRVCFVQCFSEADRDIMTLANHWNCPVLSSDSDFCIFDLKTGFCPLNSFQWRNMDTIKGTQNYIPAKCFSLDAFCHHFSNMNKALLPLFAVLCGNDHVNLPIMETFLSKARLPLGATSSKGRRHHRILGLLNWLSHFANPTEALDNVLKYLPKKDRENVKELLCCSMEEYQQSQVKLQDFFQCGTYVCPDALNLGLPEWVLVALAKGQLSPFISDALVLRRTILPTQVENMQQPNAHRISQPIRQIIYGLLLNASPHLDKTSWNALPPQPLAFSEVERINKNIRTSIIDAVELAKDHSDLSRLTELSLRRRQMLLLETLKVKQTILEPIPTSLKLPIAVSCYWLQHTETKAKLHHLQSLLLTMLVGPLIAIINSPGKEELQEDGAKMLYAEFQRVKAQTRLGTRLDLDTAHIFCQWQSCLQMGMYLNQLLPTPLPEPDLTRLYSGSLVHGLCQQLLASTSVESLLSICPEAKQLYEYLFNATRSYAPAEIFLPKGRSNSKKKRQKKQNTSCSKNRGRTTAHTKCWYEGNNRFGLLMVENLEEHSEASNIE", "function": "Possible role in EGF receptor signaling.", "AFDB_id": "AF-Q5RCY5-F1-model_v4" }, { "swissprot_id": "Q14CM0", "sequence": "MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV", "function": "Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.", "AFDB_id": "AF-Q14CM0-F1-model_v4" }, { "swissprot_id": "Q3EDH0", "sequence": "MESNYSGVVNGYDVSFLPTSIPDLGFGVPSSSDFDLRMDQYYHQPSIWVPDQDHHFSPPADEIDSENTLLKYVNQLLMEESLAEKQSIFYDSLALRQTEEMLQQVISDSQTQSSIPNNSITTSSSSNSGDYSNSSNSSVRIENEVLFDNKHLGDSGVVSFPGSNMLRGGEQFGQPANEILVRSMFSDAESVLQFKRGLEEASKFLPNTDQWIFNLEPEMERVVPVKVEEGWSAISKTRKNHHEREEEEDDLEEARRRSKQFAVNEEDGKLTEMFDKVLLLDGECDPQIIEDGENGSSKALVKKGRAKKKSRAVDFRTLLTLCAQSVSAGDKITADDLLRQIRKQCSPVGDASQRLAHFFANALEARLEGSTGTMIQSYYDSISSKKRTAAQILKSYSVFLSASPFMTLIYFFSNKMILDAAKDASVLHIVDFGILYGFQWPMFIQHLSKSNPGLRKLRITGIEIPQHGLRPTERIQDTGRRLTEYCKRFGVPFEYNAIASKNWETIKMEEFKIRPNEVLAVNAVLRFKNLRDVIPGEEDCPRDGFLKLIRDMNPNVFLSSTVNGSFNAPFFTTRFKEALFHYSALFDLFGATLSKENPERIHFEGEFYGREVMNVIACEGVDRVERPETYKQWQVRMIRAGFKQKPVEAELVQLFREKMKKWGYHKDFVLDEDSNWFLQGWKGRILFSSSCWVPS", "function": "Probable transcription factor involved in plant development.", "AFDB_id": "AF-Q3EDH0-F1-model_v4" }, { "swissprot_id": "P78871", "sequence": "MTRESLAPIASKANTLSESKVSENLMSINSDSGTSNANTPSSVTSNSKPVASSTAAKKDPNAPPQKVKQYVCETCTRAFARLEHLKRHIRSHTNEKPFTCSEIDGLPTGCGRQFSRRDLLLRHQQKIHRNPQPRRRRRSTTALPNPSLSNVSVSTTNLASKPVISLPQADSIDKFRYPKLHAALQAQLANNSGSFSASWLQAQQQRLVSAGNGRETVNASASGAVNPTSSQWSDQRLGVPYGPDSPLYYRRATIASDLRPSVYQHPQLYDFNRPESLSGQLDDESLARMPYSPNAVSRNYAMNMTLPESIPEGYEIDKLDWMSFSESLNLPTFNQPSGPSDVSASFLNLQAMPSPHASPKDSLINKSNSYFFQNPPKSNSVDYTRLDNLEHMRQSCISPSGTNFSPSCYSPESLMQQPLTLSPSSIPSGLPTYAHVNSPLGTEQYPSEAYPPKGYVDMEGRISEGIKEEGISLSEEITDKDQAFASMGYFDSYNFEGVENSNSLNNEGDQMETNFQSEKLDNSNSIPFFNFNSFNNNGANWSSDFNYPVSETSGLLTDNNRNQPPSF", "function": "Key transcription factor for sexual development. Activates the transcription of ste11. Binds to a stress response element-like (SRE) region in the ste11 promoter.", "AFDB_id": "AF-P78871-F1-model_v4" }, { "swissprot_id": "Q80YW5", "sequence": "MSADVSGTESGSESGPEPEPGPEPGPESRPESRPKPGPGPEPRPESGPEPGPRSGLRRGPKQGSERSQLCPEHFEPLSWFCLSERRPVCATCAGFGGRCHRHRIRRAEEHAEELRNKIVDQCERLQLQSAGISKYMAEVLQGKNQKAVVMASAARDLIIQRLSLVRSLCESEEQRLLEQVHGEEERAHQSILTQRAHWVDAVQKLDTLRTNMVDMITHLDDLQLIQREQEIFERAEEAEGILDPQDSEKLSFNEKCAWSPLLTQLWAASVLGSLSGVEEVLIDERTVSPLLHLSEDRRTLTFIAKKSKVCSDEPERFDHWPNALAATAFQTGLHAWIVNVKHSCAYKVGVASDQLPRKGSGNDCRLGHNAFSWVFSRYDQEFCFSHNGYHEPLPLLRCPAQLGMLLDLQAGELVFYEPASGTVLHIHRASFPQVLFPVFAVADQLISIVRGPLATVRLDSPPHHPCRSGHASR", "function": "May regulate epithelial calcium transport by inhibiting TRPV5 activity.", "AFDB_id": "AF-Q80YW5-F1-model_v4" }, { "swissprot_id": "P0AEW7", "sequence": "MKFPGKRKSKHYFPVNARDPLLQQFQPENETSAAWVVGIDQTLVDIEAKVDDEFIERYGLSAGHSLVIEDDVAEALYQELKQKNLITHQFAGGTIGNTMHNYSVLADDRSVLLGVMCSNIEIGSYAYRYLCNTSSRTDLNYLQGVDGPIGRCFTLIGESGERTFAISPGHMNQLRAESIPEDVIAGASALVLTSYLVRCKPGEPMPEATMKAIEYAKKYNVPVVLTLGTKFVIAENPQWWQQFLKDHVSILAMNEDEAEALTGESDPLLASDKALDWVDLVLCTAGPIGLYMAGFTEDEAKRKTQHPLLPGAIAEFNQYEFSRAMRHKDCQNPLRVYSHIAPYMGGPEKIMNTNGAGDGALAALLHDITANSYHRSNVPNSSKHKFTWLTYSSLAQVCKYANRVSYQVLNQHSPRLTRGLPEREDSLEESYWDR", "function": "Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.", "AFDB_id": "AF-P0AEW7-F1-model_v4" }, { "swissprot_id": "Q2YA93", "sequence": "MNPMPSALPSDFLHVDLVTLSPLILLAAAAVVVMLTAAFYRHPRPVMILTLAGLVLSFMALFLSQGTASSQVTTLLILDQYALFFIGLIVVATFVVAILCYRYFGGGESRHEALYILLLLAALGGGVLVASSHFASFLLGLELLSISLFALIAYPRFTEHPLEAGIKYLILAGFSSGLLLFGMALVYAQLGTMQFVKIGTMLAAPGAALELYGLAGLALIVTGVGFKLALVPFHMWTPDVYEGAPVPITAFIATASKGAMLVLLLRYFLMAGAHQSHSITFALSLIAVATILVGNLLALLQNNIKRILAYSSIAQLGYLLVGFLAFDQLAIEAVAYFLTAYFVTMLGAFGVVTVLSEGFNGGSAGEFHDAGEKDSDRLADYAGLFWHRPWLAGVFTAMLLSLAGIPLTMGFIGKFYIVTAGVEASLWMPVITLVIGSIIGLFYYMRIIAVMYGWGPEAAGEAIMLRAASPSFAESATLAALALLLIWLGIFPAQLIGVLEGAGGGLT", "function": "NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-Q2YA93-F1-model_v4" }, { "swissprot_id": "Q298S5", "sequence": "MSHLSTINACKLLLFRRCLQAVLLTVGIQFLLLTIFLLFVNFQLLRPLHWISVTLSLVCSMYTWFASIPLVGAVVLYGMILCQQHLAERLYCPTRFRWLVHYAPRKLLFLAAHLLVGYLTAWLYTGYMHTDYRHLWYKCYDQECISAYHVYLLGMGIFAGCYYFVSVHMRQEVEIEFPIVNHLWGEKLREVLYSSLARSLIKSLLPTLAYTLLFWLFGGVVCHKLSHIFAVDLDERLEGFFGVATNGRLLFYGWLLTSQILSNMHLMRCFYSMFLSEEFPLAITKNRAAFVQEKEVTVVAALGLSNVYVVQCLAAKYLYNLVTAGDAEKRSELFQLTEPGNRPANWRSLCDQCLSLFGNFTDELIDSMQKISVLKGSPSSPPLTPISENASASLMAERVLTRQYNQMHGIRAIVSPRSNAVIDRPVDRIHRVPDWCERTSMQLEQSLQLLINRIPGIVYMFTEPEGAKTAFLLTHSLPLVFVIQALSQICVFSLKEDRYGVVQTDLPDIIRSMSRLKGELDKLSSVASNLRGPGSSFSVLRGAVRRSLFHICVAFGEYLSELIPSGEELHQLQTVINQE", "function": "Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope.", "AFDB_id": "AF-Q298S5-F1-model_v4" }, { "swissprot_id": "P16554", "sequence": "MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL", "function": "Required in determination of cell fate during sensory organ formation in embryos. Restricts developmental potential and promote maturation of intermediary neuronal progenitor (INP) cells probably acting as an antagonist of Notch signaling.", "AFDB_id": "AF-P16554-F1-model_v4" }, { "swissprot_id": "P11682", "sequence": "IPGLSEKYTGEELYLMTTEKAAKTADICLSKLQEYFDALIAAISELEVRVPASETILRGRNVLDQIKEMLKHLQEKIRQTFVTLQEADFAGKLNRLKQVVQKTFQKAGNMVRSLQSKNFEDIKVQMQQLYKDAMASDYAHKLRSLAENVKKYISQIKNFSQKTLQKLSENLQQLVLYIKALREEYFDPTTLGWSVKYYEVEDKVLGLLKNLMDTLVIWYNEYAKDLSDLVTRLTDQVRELVENYRQEYYDLITDVEGKGRQKVMELSSAAQEKIRYWSAVAKRKINEHNRQVKAKLQEIYGQLSDSQEKLINVAKMLIDLTVEKYSTFMKYIFELLRWFEQATADSIKPYIAVREGELRIDVPFDWEYINQMPQKSREALRNKVELTRALIQQGVEQGTRKWEEMQAFIDEQLATEQLSFQQIVENIQKRMKT", "function": "Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.", "AFDB_id": "AF-P11682-F1-model_v4" }, { "swissprot_id": "Q9LP74", "sequence": "MTKLVSKIFKRLISQSQYMSSSTTSNLPAASQTSNLESQLLSSAPPPAKKKRGSALLWYLVGFTTYGLGETYKFLQTQVEHLDSRKQCLEMKPMKLNTTKDLDGLGFRRVVCKGIFDEQRSIYVGPKPRSMSKSSEIGFYVITPLLPIPNEPNSMKSPILVNRGWVPSDWKENSLESLGTGGLVAAAKESRKANKLLSSQQSLLSKFWYKLNNPMIVEDQVSRAMHVEVVGVVRKSETPGIYTLVNYPSSLAWFYLDVPKLALAMGFGEDTMYIESTYTDMDESRTYPVPRDVENLTRSKDIPLDYHLYTVLWHWSSLTCFIKASSILMRRLTKSDPIGVEPILIPISILVFICTKIYSLRNLFCKIDTIGVGCVTKLDTGKVK", "function": "May be involved in the biogenesis of the COX complex.", "AFDB_id": "AF-Q9LP74-F1-model_v4" }, { "swissprot_id": "E0U4V7", "sequence": "MKISIVIPVYNSEDLISECLDSLVNQTMPKEDYEIICVDDKSTDSSLDILNQYKKKYENVVVIERTVNSGGPGAPRNDAIKIAKGEYILFVDSDDYIGSEALLRWYNFSKENQSDITLGKLKGINGRGVPKSMFKETNPDVDLVDSKIVFTLGPQKLFKASLLKENKITFPTHIKAAEDQVFTMNAYLKAKKISVSADYDYYYLVKRDGEHMSVAYVPPENFYGAMEDIISAIKASDLEEARKIKLMAVFLNRHFDFSRTKNVTIKMKTDEERAEWFRYLSSFIHAVPEEADQFVLPHIKLRLLFIRNNDLRGLTQYEREEQDIKKFCTVNNGELIARYPSLERYSISEELLKVNYKNKLEHYLQNIEFSDHSLSIQGTITHKLLDDETNKNQSLTGVFVHRDTKAEKYIAPASYDNSTFTFECKFDELASAEEDLGVWDFFIESSIDGYKLRARIGNKRAAYKYSTKTMYLGHNALFVYSARPYFTMNYDNLSIDIKKHAYTEAELSYETESKDLSFIFKDKQIYLPNHSKIIVNTGQSEISLPVKRIDLEPNCTKLTVNVQSLLEQLAHVKKERLIEFAINTSQNKISAKVDNQAIILDTKSVERKSMLFFNKMVEVQYKLLTSKSKFYFQY", "function": "Attaches glucose residues to poly(RboP)-wall teichoic acids (WTAs).", "AFDB_id": "AF-E0U4V7-F1-model_v4" }, { "swissprot_id": "P34609", "sequence": "MACNLSPVNEMADSITSSTPSEIVYGGPGSPDEHRTMSDKVQTMASAIYRELETMIKVHGEDGVKTLMPLVVNVLEALDLAYLERDEQTAELEMLKEDNEQLQTQYEREKALRKQTEQKYIEIEDTLIGQNKELDKKIESLESIMRMLELKAKNATDHASRLEEREVEQKLEFDRLHERYNTLLRTHVDHMERTKYLMGSEKFELMQNMPLPNMQLRNKMGMAASVDASSIRGVSDLISAHMTQSTTMDVNLANHITNEDWQDEFSSDIEPSPRDIPQSSADALTSPITTKEPTPKREAASPKQSEEEEADETTSVDPKENNDLLGADLTDDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSLGMGREVENLIKENSELLDMKNALNIVKNDLINQVDELNSENMILRDENLSRQMVSEKMQEQITKHEEEIKTLKQKLMEKENEQEEDDVPMAMRKRFTRSEMQRVLMDRNAYKEKLMELEESIKWTEMQRAKKMQQQQQNVNQKKSGGIWEFFSSLLGDSVTPPASSRGNRASSSRGKMTRSVEYIDPDMISERRAAERREQYKLVREHVKKEDGRIEAYGWSLPNVEAEVSSVPIPVCCRPLLDNEPSLKIWCATGVVLRGGRDERGQWIVGDPIYFAPASMKKTKTSNHRPELEDEIKRARNLDARESELDEWQSSSLVWVVSSNQGKSLIAVLDANNPNNIIETFPACDSHLLCIQAVSGVMEGEPEMNEEQSKKYLSGGGKIKDLPEGLDGTDLGACEWVELRKMEDSEDGVPTYCSNDMKPSPKRTRDFSISEVAPVDSSAPVKEDPLPPPANRPGGRAALPPHIRDAMSKYDGVSGQMSGALPTVWMGGQNQYIYIHSAVTAWKQCLRRIKMPDAVLSIVHYKSRIFAALANGTIAIFHRNKHGEWSDEGYHSLRVGSATSSVRSLCLVSTNIWATYKNCVVVLDAESLQIVKVFAAHPRKDSQVRNMQWVGAGVWLSIRLDSTLRLYHAHTYEHLQDVDIEPYVTKMLGTSKLDFSYMRTTALLVSNRRLWIGTGTGVIISVPFSGQLEKKIETKDSKRPAGPGGLVRVYGATSENATNDEKTNDDFIPYCNLAHAQLSFHGHKDSVKFFLGVPGASKNGEDESAEVTLRRMLIMSGGDGYIDFRIGEENEPELTGQSIRPRDMSHLIIWEVDAELPILSK", "function": "The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Regulates the retrograde transport of autophagosomes from the neurites to the cell body of AIY interneurons.", "AFDB_id": "AF-P34609-F1-model_v4" }, { "swissprot_id": "A7NPT5", "sequence": "MTPAERRAFERQLQQEFPGLELHAWYRQYRSLKAAHPDAILLYRLGDFYETFDDDAKLVADLLEVTLTYKEFASQKGRDQKQRCPMAGIPYHAVEGYVARLVGAGYRVAIAEQMTETPSSRTDTRPRSIFAAGIEQTALIGGHKMVERKVVRIITPGTIIESGMLPAERNNYLAALIADHGRIGLAYADLSTGEFAAIEFSGERAAQQAQGELARLNPAEILVPDRADLRLPGLEPSSARLEQDLEFLTREERERVLPGERIARRVERENHARWAHGHVTAWSEQRWDLRNARDTLLHQFGVHSLAGFGLADRPLAIRAAGAIVQYARETQQGTVANLRAIRVYTPGDAMVLDPQTQRNLELLEGNSGTTRGSLIGVLDQTRTPMGARLLRRWISQPLCDLARLRARHDAVDHFVNDAILRASVRETLRRVGDMERVVNRIIQGSGVATPRDMARLRDALRALPDLVAALEDWTPPQEDVDLSGMSALQESAALAAAPLDGITPPDDDHTEQEPTTISLRAQREARRRVSARLTGDDLFDEEEEQENAGQPAPLPTTETVRASGESARPSFEMPSLHGHGESPTLDACADILAFLETAIDDDPPALLGASNYLRAGDNGELPRRVIRPGFEPEIDRVVAASRDAQRWISELEPKERERTGIKSLRVDYNRVFGYYIEVPKTYADQVPKHYIRKQTLTTGERYFTDELKRYEEIVEQAQQRLIDLERRAFARICETLAGAGVRLLRTARTIATIDVFAALAEAAVRGRYVRPELYDDTRLRIIGGRHPVVEQTLDETFIPNDIEMDTETRQICLITGPNMSGKSTVLRQVALIALMAQIGSFVPADAAEIGVVDRIFTRIGAQDDIATGRSTFMVEMTETAALLAQSTHRSLIILDEVGRGTSTYDGMAIAQAVIEYIHNEPRLGCRTLFATHYHELTDLERTLPRLKNYHMAATEQDGRVVFLHELRPGGADRSYGIHVAELAGIPQPVIRRATELLAELERRAPRSTPQPAPERTEERPAAGRPTARSHSAARGDPPRAPDGQLSLFDLTPGPVIEMLRRLDINQLTPLEALNKLYELQKLARIGGG", "function": "This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.", "AFDB_id": "AF-A7NPT5-F1-model_v4" }, { "swissprot_id": "D3FSJ2", "sequence": "MKITSGDLPGVGKKISFITSEGSMVVLVIHHTGKREMYFFDDADDDEVSFSLTLSAEETKQMGAQLLGAILNPADTDKIDRIKLIRKQVVVEWIDITKHSPIISKSIAQIEKMKPKGISIVGVFKNDEMMVDPEPTLVLEKGDTLMAVGKRDAIQKFEELCACKENN", "function": "Modulates the activity of the ammonium/proton antiporter AmhT.", "AFDB_id": "AF-D3FSJ2-F1-model_v4" }, { "swissprot_id": "Q960A1", "sequence": "MPLTGIFFNVNGKDVNEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSCTVVLGTWDDCQNKAVYRAVNACLVPLFHVHKTFVITVEGVGSRDKIHPIQDRMARGHALQCGFCSPGFVMSAYALFSNQPNPTIQQINAAIRANLCRCTGYRPILEALYSFSSESGGCCGGNKTGGGCCKDKSSSDEDGGYDEKLLSFNDFPKYDPTQEIIFPPSLRVFSDSETPVTLKGDRIELLLPKNIDQFKKFKKDRTVISSGLITRFVSTRNPKEFSQKWISTKYVKEFNEITVNKDSVVVGAALNIQKMADTLTSSLSINIGKEIDSFIQKFSSPQIANFATWTGAIISGAKSSLSVSDLLILFNVLDAKLTLLNNSGELTQVAIEEFAEKKLFATHTIVNAIFSRSLTGFLFCLKLGETSEQDSTNFNFAALVGNQVSRIFVGLGGQPKRLTSLEVHIDALKGLSVSDLCQTTEMSDYKNVKIALTRFSDFMNHKEKTEEIEGINYLQYFKPKTNESAGRPIANYFNERAITGEAFYVNDIQAYNAVHLGFVLSTVPHAEITKIDVSEALQLEGVAGYFGVSDVPGNNTPGLQISNMNFPDDTTIFADKKVESVGQVIGVIAANDVVLARRAAKLVKVEYKELPSLVNFKEAIEAKSLLGDVQHFGKDENLVKESLENSSKVLEGECDIGGQEHYYLETQSSLVIPGEGDELIVNCSTQGTSFTQLMVAETMKIPAHKIIVKTKRLGGGFGGKVNNASWIACMCAIVAKKLNRPTYGFLSRADDLAITGKRHEVHAKYRVGINFDGKIEGIHYQAWLNGGWSKDHSEGVTMVMGLMVDDVYNMGTIRFDGYPVKTNSNSNTALRGYGNPQSKLINEGVMRRIARDVGKSTEEIKRINFALEGGRRYLGGKIHNDALVECWEYCKKWSEFENRQSGIKQFNKNSTAVKRGIAMSSVRFGLPHPGPTGHGIASLLINLDGSVQLSIGGTEMGQGLNQKMLQVCSEALKRPIDTITIVDCSTDKVTNAPETGGSQNADTNGLAVLACCKKIMSRLQPIIDKNDGEWEKSIREAYGAYVPLQCTEYGTVERAKFGVGEMESPYNTTGACAVEMEIDTLTGYNRVIRVDIVMDVGESLNPALDIGQIEGAFIQGYGLVTCEKITFNKTTGQLDQNTAGKYKIPKASDVPKDFRVKLLGINNANGAQVYSSKGIGEPPLMMSCGAVHSSIMNCIDNWRNENGIHEFVDTISPLSAEKIQELCSKK", "function": "May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1.", "AFDB_id": "AF-Q960A1-F1-model_v4" }, { "swissprot_id": "Q10589", "sequence": "MASTSYDYCRVPMEDGDKRCKLLLGIGILVLLIIVILGVPLIIFTIKANSEACRDGLRAVMECRNVTHLLQQELTEAQKGFQDVEAQAATCNHTVMALMASLDAEKAQGQKKVEELEGEITTLNHKLQDASAEVERLRRENQVLSVRIADKKYYPSSQDSSSAAAPQLLIVLLGLSALLQ", "function": "IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities. Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu. Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2.", "AFDB_id": "AF-Q10589-F1-model_v4" }, { "swissprot_id": "P53219", "sequence": "MMILGKAGILAQYGTIYVRQNTIRNNLSSCIFKQSLCAFHSLAKVLQQKQVPLDLSYDIIKRDAVKTGDEGKPRPPIIILHGLFGNKLNNRSIGRNLNKKLGRDVYLLDLRNHGSSPHSSVHNYEVMSEDVKHFITKHELNTNGGPIIIGHSMGGKVAMMLVLKNPQLCSMLVCIENAPVSLRPNAEFVEYIKALMEIVNDKGKTIRTLKQADEHLAERIGGNELVRRFLLTALKKVKMDNSSSVSSYTFEERIPLATLKDAIVKGEIAAWPLDPARERWTRPALFIRATQSHYVVDEYLPIIGAFFPRFETRDIDAGHWVNAEKPGECAESIVDFVERHED", "function": "Probable alcohol acetyltransferase that uses acetyl-CoA to synthesize acetate esters from various alcohols (Probable). Not involved in the synthesis of ethyl acetate.", "AFDB_id": "AF-P53219-F1-model_v4" }, { "swissprot_id": "A9V196", "sequence": "MAGGYIARVNMKGHYLSWSSDNTYPWQNIQPTQNTKLLGLQDIGFTTDPVRRLRQHNSEIGGGAVRTTRAKGSWDMAAIVYGFPNKVAALRFEWAWQHPLKSRRLRDAVRSDLPASRAAQMQLTAKLHTLAAMLYTVPWSDQPLTLCWLQPDIADKWSNIWQRHCQCQSALPPFLTTRSGNLQDPLFQLNNAAAAASTIQRAALAADHHAWRLAAAAQAQAPDFFTGLGRLDLAAPSVEESGAGPHPSSCSVPPSTGSSAAPTPGALAPQPTKQNKFGVDPRLDSDDRDDNHQFESPDNHEAAAVNVDVVDDSADDGTTDGNEDGPDDVAPHQEVTARHVHGAIGETCGHCHQSVYQELCIVCLNATCTYRAHLLCAAQAAVHPLGQSSPSETRLVPLRHSCPRCAHQAHWASWIAEVTL", "function": "Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.", "AFDB_id": "AF-A9V196-F1-model_v4" }, { "swissprot_id": "Q8K099", "sequence": "MWVALGMLWLLALGGPHQAWGFCPSECSCSLRILSDGSKARTVVCSDPDLTLPPASIPPDTCKLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSALMLRGLRRLRELRLPGNRLVTFPWAALRDTPQLQLLDLQANRLSTLPPEAAHFLENLTFLDLSNNQLMRLPEELLDVWAHLKTGPFLSGHHARLILGLQDNPWVCDCRLYDLVHLLDGWVSSNLIFIEARLRCASPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLGSTVLLRCGATGIPGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETLISLIVTEPQTSTGYSGIPGVLWARTGEGAEAAAYNNKLVARHVPHMPEHVALATKPSMPSIKEELALQNFQMDVPGEFSREPSEHQEAQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGHRDMRRMTVEPGKTSVTIEGLAPKTKYVACVCVRGLVPTKEQCVIFSTDEVVDAEGTQRLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRTGGSAEASGAYVNLERLGHSEDSSEVLSRSSLSEGDRLLSARSSLDSQVLGVRGGRRINEYFC", "function": "Possible role in phototransduction.", "AFDB_id": "AF-Q8K099-F1-model_v4" }, { "swissprot_id": "Q8TY76", "sequence": "MIIATLTGRTIEDMVELAIEAVEQGADALEVRLDYLENLDMSTALRAVRECTRYERVVATLRREEEGGLYKGDEDRRLEILERVSSEADYVDLELDVAEEEIISPSCETIVSYHNFENTPPKEELIGIRDRCAELGDVAKVVTMARGHEDALRILEVVRTAEAPTIGFAMGEEAKYTRVVSVLIGGFATYAAVRKKAAPGQLTVEETRKLLELLG", "function": "Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.", "AFDB_id": "AF-Q8TY76-F1-model_v4" }, { "swissprot_id": "P35729", "sequence": "MACLSRIDANLLQYYEKPEPNNTVDLYVSNNSNNNGLKEGDKSISTPVPQPYGSEYSNCLLLSNSEYICYHFSSRSTLLTFYPLSDAYHGKTINIHLPNASMNQRYTLTIQEVEQQLLVNVILKDGSFLTLQLPLSFLFSSANTLNGEWFHLQNPYDFTVRVPHFLFYVSPQFSVVFLEDGGLLGLKKVDGVHYEPLLFNDNSYLKSLTRFFSRSSKSDYDSVISCKLFHERYLIVLTQNCHLKIWDLTSFTLIQDYDMVSQSDSDPSHFRKVEAVGEYLSLYNNTLVTLLPLENGLFQMGTLLVDSSGILTYTFQNNIPTNLSASAIWSIVDLVLTRPLELNVEASYLNLIVLWKSGTASKLQILNVNDESFKNYEWIESVNKSLVDLQSEHDLDIVTKTGDVERGFCNLKSRYGTQIFERAQQILSENKIIMAHNEDEEYLANLETILRDVKTAFNEASSITLYGDEIILVNCFQPYNHSLYKLNTTVENWFYNMHSETDGSELFKYLRTLNGFASTLSNDVLRSISKKFLDIITGELPDSMTTVEKFTDIFKNCLENQFEITNLKILFDELNSFDIPVVLNDLINNQMKPGIFWKKDFISAIKFDGFTSIISLESLHQLLSIHYRITLQVLLTFVLFDLDTEIFGQHISTLLDLHYKQFLLLNLYRQDKCLLAEVLLKDSSEFSFGVKFFNYGQLIAYIDSLNSNVYNASITENSFFMTFFRSYIIENTSHKNIRFFLENVECPFYLRHNEVQEFMFAMTLFSCGNFDQSYEIFQLHDYPEAINDKLPTFLEDLKSENYHGDSIWKDLLCTFTVPYRHSAFYYQLSLLFDRNNSQEFALKCISKSAEYSLKEIQIEELQDFKEKQHIHYLNLLIHFRMFEEVLDVLRLGHECLSDTVRTNFLQLLLQEDIYSRDFFSTLLRLCNAHSDNGELYLRTVDIKIVDSILSQNLRSGDWECFKKLYCFRMLNKSERAAAEVLYQYILMQADLDVIRKRKCYLMVINVLSSFDSAYDQWILNGSKVVTLTDLRDELRGL", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP120 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.", "AFDB_id": "AF-P35729-F1-model_v4" }, { "swissprot_id": "B2UNU8", "sequence": "MEGNLSFSLMEASGRSIFFLIEGIREQSIKNMFSRMFSWSFVVAACLAGLFPAQSQGEEKAAQSGTIAVKVPASSLLMTRQETGETRLDRSFSNAGLSIGGKKYATGIGTHATSMIPLPVPENPKVLRLEGACGIDDGADGDGSVEFRVMSGSEVLWSSGVMRRGMAAKKFSIPVAENGIRHLYLMADRVDNNSYDHADWVDLAWKTTGSGQGMKGAVVNASEFGMVPGVRKDQGPALRAAVSALRRQGGGVLNIPRGIYHFYPEGALNMSFHISNHDQPLIHPVCVPLADLRNVRVEGNGSLFLFHGKVVPLLVMDSENVSINRLSVDYERSWCTEARVVKTDDRFTEVEIDKKAYPYEIRNNRFVFQGKGWEEGMGSCMAFEKGTGHIIANTSDIGWNGHVEPLGGSRLRLSWNLRQKGIKPGDTLVLRNYNRPHPGCVVYRARKTSLNDVSLHQSSGMALLVQRSEDFHMKGGGVMVRKGTGRVHTAGADATHFSNTRGGIVVEKALFEGMMDDAINVHSTCLGVMEVVDSHTLKCKYMHRQAVGFEVFLPGEKIRFINGPTLEPGGTATVKTAVKKNSAEMVITVEEPLPSSVRAGDAVENADFYPSVVFRNNIVRNNRARGSLFTTPERVLVEGNLFDHSSGSAILLAGDAQGWYESGACHEVVIRKNTFINNLTSRYQFTNAIISIYPEVKQLDRQRDYYHRNVLIENNVFKTFDVPLLFAISTDNLKFINNKVIYNDEFKGWGQKPFQFRRCANILIKDNKVLPPRTWTLEDCKLENTPSDQVRFGG", "function": "Alpha-galactosidase. Removes both branched alpha-1,3-linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures.", "AFDB_id": "AF-B2UNU8-F1-model_v4" }, { "swissprot_id": "Q3KP66", "sequence": "MLQMPKLNEIPPGRAGRREARGEGRWPGQTGPEAARLEWRAQGQAGGARAPWDSWGSSRLPTQPGPGWSRCPPSLLCALSFQKSTMESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRIVRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFGRALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV", "function": "Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.", "AFDB_id": "AF-Q3KP66-F1-model_v4" }, { "swissprot_id": "Q6R2R2", "sequence": "MSCSLARLCLLTLLSPPLSSAASISPAEPISQAYSLALYMQKNTSALLRTYLQYQGSPLSDPGFSAPELQLSSLPPATAFFKTWHALDDGEWLSLAQRAFLALTQHLQLVEDDQSDLNPGSPILLAQLGAARLRAQGLLGNMAAITTALGLPIPPEEDTLGLAAFGASAFERKCRGYVVTREYGHWTDRAVRDLALLKAKYSA", "function": "May have an important role in neuronal precursor development and maturation.", "AFDB_id": "AF-Q6R2R2-F1-model_v4" }, { "swissprot_id": "Q9UKE5", "sequence": "MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW", "function": "Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.", "AFDB_id": "AF-Q9UKE5-F1-model_v4" }, { "swissprot_id": "P11068", "sequence": "MGSAAAHRGDTTQAVRHDRANHLWLERIVRSQRDGLSCLPFHLGLDERSYAELIRTHFPELAGQTSASLGSLAHECSELREDLLEMRRDEWEELRVLLLDGRRGDDPEELWMASIVAAACLGGDHLWRDLGLESRETLRVLLMHNFPHLAERNVKNMRWKKFFYKQLCEQDGGYVCRSPSCEQCPSHHDCFGAEI", "function": "Probably involved in molybdenum processing.", "AFDB_id": "AF-P11068-F1-model_v4" }, { "swissprot_id": "P37017", "sequence": "MMTFKNLRYGLSSSVVLAASLFSVLSYAATDSIGLTVITTVEMGTCTATLVNDSDQDISVVDFGDVYISEINAKTKVKTFKLKFKDCAGIPNKKAQIKLTKRATCEGTANDGAGFANGSTAADKASAVAVEVWSTVTPATGSATQFSCVTPASQEVTISTAANAVVYYPMSARLVVEKNKTVNNVTAGKFSAPATFTVTYN", "function": "Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.", "AFDB_id": "AF-P37017-F1-model_v4" }, { "swissprot_id": "Q49128", "sequence": "MRAILPIPVLIAWAMVVCGGAYAVTTCSGAATATADASQQDLAALKARFRRPESVPHPKANPLTPEKVALGKALFFDPRLSRSGSVSCATCHNPSLGWSDGLTRAVGFGMVPLPRRTPPVLNLAWGTAFQWDGRADSLEAQARMPITAPDEMNMSMDLVVERLKAVPGYAPLFRNAFGSEEPIGARHVTAALATFQRTLVSGEAPFDRWALGDESAIGADAKRGFALFTGKAGCAACHSTWRFTDDSFHDIGLKAGNDLGRGKFAPPSVTAMRYAFKTPSLRDLRMEGPYMHDGQLGSLEAVLDHYIKGGEKRPSLSFEMKPFEMSERERRDLVAFLETLKAEPAAITLPQLP", "function": "Involved in methylamine metabolism. Essential for the maturation of the beta subunit of MADH, presumably via a step in the biosynthesis of tryptophan tryptophylquinone (TTQ), the cofactor of MADH.", "AFDB_id": "AF-Q49128-F1-model_v4" }, { "swissprot_id": "Q6Z433", "sequence": "MSGHHEAKPYQPRRGPAPADEEAAPAAAADEAEAEAEVEAMERYEQEQEYEEGEEGEEEEYEGGEGVPMDADASAAAVAGMDPHGEMVPVAGGEAGGGYPHVASNTLTLSFQGEVYVFESVSAERVQAVLLLLGGRELAPGSGSVPSSSAAYSKKMNFPHRMASLMRFREKRKERNFDKKIRYTVRKEVALRMQRNRGQFTSSKSKAEEATSVITSSEGSPNWGAVEGRPPSAAECHHCGISAASTPMMRRGPDGPRTLCNACGLMWANKGTMREVTKGPPVPLQIVPAATNDVQNGIVEATGVEQHNSAVEEAVSAANGHESQSGVA", "function": "Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.", "AFDB_id": "AF-Q6Z433-F1-model_v4" }, { "swissprot_id": "O59793", "sequence": "MSLAKKIDDDEKQLVKPVNKEQTYKKPIPLEEDDYIEGLSYIIQQQYFPDLPKLKAEVVLESEEVGSFDAQNESRDEKLKYLIAKNSEDPLRKRLPSLAIHEITKAQLDGENKPISVASYQNKFTSEDNASFGELMEDESRLRAEQHKRRFGVHSQQPSNSIQTIGYSNSDAIKSIAWKEKDKSIKTWNYQPKNALMYTPETNHSSSLSQIKKQSTEIQADATGLSQSFLEAANQPSTDPIVPPSVNETDASVNGYPLVDVNFGQAVGSSSKSYFNIPERPRRERLHAMRVRDIRSHSTNTTITSVDSASTALNSYSTPNSVSRKLTNLTPAARRLVARSYLRSPLHGSSPSASRHTALRTSIPKFSWTPTPRVKSTAPTPKRV", "function": "Has a role in maintaining cell viability during stationary phase induced by stress response. May be involved in pre-mRNA splicing.", "AFDB_id": "AF-O59793-F1-model_v4" }, { "swissprot_id": "A1SYY3", "sequence": "MTADKQSSTLKLNRLLQLCSANLPVGGFSFSQGLEYAVEMNWISGQKSTFEWIELNLSESLSRTDLAILKRLYQALDSSDFTAFKLANQHLIACRESSELRFADLAMGKAFVRLLKQLDSLDSEPYSELLNEPELSFVSVFAISAYLCELDLTAAQSGFCWTYIDNQVAAATKLVPLGQTQAQNLLFDLSAEVDHLLTIANQLKDHEIGGSLPRLAMASAWHETQYTRLFRS", "function": "Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.", "AFDB_id": "AF-A1SYY3-F1-model_v4" }, { "swissprot_id": "Q9VSY4", "sequence": "MVEFRFDIKPLFAQPIIKVTSNLLPNTFRGDRRQCLDATSKMTEIIDQLGQLSATSQGLSKPVTTAQRLRMSDNQTIYLLADNEAGHNGAVLGLLKVGTKNLYLFDEAGKTRMVEQTPSILDFYVHESRQRAGLGKRLFQTMLNEEQWTARKCSVDRPSEKLLSFLSKHYGLKRIIPQANNFVLYEGFFNDGESGNGGGNGHANGTPNGLHITNSPNTHLFGATYLGEDSNQRRGSQQQTTPNARLQQITQISPSGRYGAKRPTCSMAEIIHAGNSKGGNGNGSAEANSGNGNHDIPEIAEQLQRQSLADLEANSYEPEPEVEPEPEPEPEPEPEPEVITPPSPPPKSHTPTPPSVRSPEVAESIVGDNRRAPAFQLSKQHTGMKNRSFGVGMAVMPSSKMEFDQMEREDFGVVKINRPPGHEVTSPGQDNTDAMSTVSSGGGGLTDQGYYDLKFYHNKLW", "function": "Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.", "AFDB_id": "AF-Q9VSY4-F1-model_v4" }, { "swissprot_id": "Q6CR06", "sequence": "MNIKQFFVPAGKPLSGLAVGLSIFLTALFLVNNLVYPINEHLLLKPDSLFKFDLNRISLYPLAHLSFFHLFFNVISTFSMIVMFEESHGTLYTGVILNLLAVFTAIPYCLIGSLLFPNVEIGGASGWFFSFLGYFAVKESRVRNSVMITSTFSFPTLYFPVALLFVTALLAPGSSLPGHAIGLLLGYFMGLKENWVAKITPPSFVLKKIETWVDPLINLIPFGIKYYREVEVDRSLEYTSVYLGSESRLPLHNTDTPAEPTFQGNGRVLGN", "function": "Probable serine protease.", "AFDB_id": "AF-Q6CR06-F1-model_v4" }, { "swissprot_id": "P54789", "sequence": "MPRRKSLRSQLLINGIDKSLLSDDSADSSDIDEEEVYGVWTEEPFQKEAGRSYYRSLKKNDVIYRVGDDITVHDGDSSFYLGVICKLYEKAIDKHSGKKYVEAIWYSRAYAKRMEIKPEYLLPDRHINEVYVSCGRDENLTSCIIEHCNVYSEAEFFSKFPAGIPTKRKDLFPCNFFIRRGVHLKVNKYTEPLDWSYYAHNLERIEDLLVEMEENLRPTKKKSGSRGRGRPRKYPLPNVESKESSSKVNSKDENFDLQDDSESSEDNLTIQPQTPRRRHKRSRHNSSNLASTPKRNGYKQPLQITPLPIRMLSLEEFQGSPHRKARAMLHVASVPSTLQCRDNEFSTIFSNLESAIEEETGACLYISGTPGTGKTATVHEVIWNLQELSREGQLPEFSFCEINGMRVTSANQAYSILWESLTGERVTPIHAMDLLDNRFTHASPNRSSCVVLMDELDQLVTHNQKVLYNFFNWPSLPHSRLIVVAVANTMDLPERILSNRISSRLGLSRVPFEPYTHTQLEIIIAARLEAVRDDDVFSSDAIRFAARKVAAVSGDARRALDICRRASELAENKNGKVTPGLIHQAISEMTASPLQKVLRNLSFMQKVFLCAIVNRMRRSGFAESYVYEVLEEAERLLRVMTTPDAEAKFGELILRRPEFGYVLSSLSENGVLYLENKSSRNARVRLAIADDEIKLAFRGDSELAGIA", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.", "AFDB_id": "AF-P54789-F1-model_v4" }, { "swissprot_id": "O95201", "sequence": "MSADGGGIQDTQDKETPPEVPDRGHPHQEMPSKLGEAVPSGDTQESLHIKMEPEEPHSEGASQEDGAQGAWGWAPLSHGSKEKALFLPGGALPSPRIPVLSREGRTRDRQMAAALLTAWSQMPVTFEDVALYLSREEWGRLDHTQQNFYRDVLQKKNGLSLGFPFSRPFWAPQAHGKGEASGSSRQAGDEKEWRGACTGAVEVGQRVQTSSVAALGNVKPFRTRAGRVQWGVPQCAQEAACGRSSGPAKDSGQPAEPDRTPDAAPPDPSPTEPQEYRVPEKPNEEEKGAPESGEEGLAPDSEVGRKSYRCEQCGKGFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPACRKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICAKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYACPLCGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALATPPPAPT", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-O95201-F1-model_v4" }, { "swissprot_id": "Q6CBX2", "sequence": "MSFTEEETKLGKSLFEACSFTERPIAKDSHLETVRQVMRKNIPATITTSDLGLFTDEEEATKKKEIIQGDITIDGTTPLHVICSSFPSDATAEELEVALEMMRELFQWGAGWMLLDEQGQTPGCVAWDRSKAEARDSVLASVYNEIVSAGTRSEVFLRRINKSENVEFLSDDDDEEMDVDDDEEDESRDGEETGDIQQAIADAIKQAKEAGLEVVVDGETVEEVPELVGDKEDEKNNESAAQNEVDLAGSQMDYLKDKLTYTDDNKTLITTQNDGVMMDWEDEIMQKSADLLVSRADKESDGPVVLNVGFGLGIIDTYLQSKKPSKHYICEAHPDVLEKMEKDGWMDKPGVTVLVGRWQDTLPGLLSQGVYFDGMYYDTFSENYSDLVDFFDHVVGLLAPTGVFSFFNGLGADRQVCYDVYKNVVEVDLQEYGLNVEYQVIKVNKDVTGADGHVWDGIKRRYWVVEDFYLPVCTF", "function": "S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.", "AFDB_id": "AF-Q6CBX2-F1-model_v4" }, { "swissprot_id": "Q8GUL2", "sequence": "MEHQNAVKEALNALYHHPDDTVRVHADRWLQNFQGTLDAWQVADNLLHDSSSNLETLIFCSQTLRSKVQRDFEELPPGAFQKLRQSLTTLLKKFHKGPPKVRTQISIAVAALAVHVPAADWGDGGIISWLRDEMHMHPEYVPGFLELLTVLPEETFNYKIAARPDRRRQFEKELTSQMEAALSILSACLKISELKEQVLEAFASWLRLRHGIPGTVLACHPLVHAALSSLNCDPLSEASVNVISELIHHTASPSSGGISAQTPLIQVIVPQILSLQAHLRDSSKDEEDVKAIGRLFADVGDSYVELIATGSDEPMVIVHALLEVTAHPEFDIASMTFNFWHSLQLMLTKRESYSSLGSEASIEVERNRRLHIFQPAYQSLVSLVGFRVQYPEDYQGLSYEDLKEFKQTRYAVADVLIDAALILGGDTTLKILYMKLLEANAQTGNNFQDWRPAEAILFCIWAISNYVSVVEAEVMPQVMALLQNLPQQAQLLQTACLLVGAYSKWLNAAPASVSILPSIIRILMSGMGTSEDCAAAAALAFRHTCDDCRKNLCGYFEDLFNIYCMAINGGGGYKVSAEDSLNLVEALGMVVTELPLDQAKGALEKLCFSAASPLEEAAKEDLEKKHARELTVHIDRFAFLFRYVNHPEAVAAEINKHWAIFRVIFDARPWDMRTMESLCRACKYAVRTSGRYIIDTIGEMLEKIQFHYQQHHQPCFLYLSSEVIKIFGSDPSCAVYLKNLIETLFAHTTCLMTSIKEVTARPDIADDCFLLASRCLRYCPHLFIPSPIFPALVNCAMIGITVQHREACHSILTFLTDIFDLEKSVNEEQFVRIRDNIIIPRGATITRILIASLAGALPSSRLDTVTYSLLALTRTYRLQAVSWAKESVSLIPRTALTETESTKFLQALSDIAYGADVNSLIGQVEELSDVCRRNRTVQELVQAALKPLELNLVTAPVS", "function": "Functions as nuclear import receptor for serine-arginine rich (SR) proteins. Regulates nuclear import of SR proteins that are required for proper splicing of the two resistance (R) genes SNC1 and RPS4, a crucial step for their functions in plant immunity.", "AFDB_id": "AF-Q8GUL2-F1-model_v4" }, { "swissprot_id": "Q37374", "sequence": "MKLNYDFFLNKFNNVYNNDIRLVDLSNKWWYHNCRVHFAGNQKHSFHIVTRSPWPLYSSIAALMFTFGLVMHMHNYFYGNLLSLAGFFLILLMMFVWWRDVIRESTFSGYHTKKVQQGLRLGVILFIISEVMFFFSFFWAFFHASLSPSVVLGSVWPPLGINVLNPLKIPLLNTLILLLSGLTVTWSHHVIRDKSWQKFFFSNSNNEEFKAPLLDNYVICAFALFLTVFLGLEFTVWQGYEYYKASFYIYDGVYGSTFYMTTGLHGLHVIIGTLFLIVCFFRLIDLHFIYNHHFGYEAAIWYWHFVDVVWIFLFLSIYCWGSGVDSFFK", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.", "AFDB_id": "AF-Q37374-F1-model_v4" }, { "swissprot_id": "Q9YD20", "sequence": "MKSRRSRCRRSFTTLVRREEERLARWALELARRGLTGEARRVAEQLFQLAASTRVRPPRRVKRLFCKNCRTPLIPGLTARVRLRSQGGMSYTVVTCLSCGWIHRYPYRKGPRGGAPISPPAAEYGSGGRDSGEREDKGPQGPPRQGGRDNRQGGGHQGGPKGD", "function": "Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.", "AFDB_id": "AF-Q9YD20-F1-model_v4" }, { "swissprot_id": "P01172", "sequence": "MSSSPLRLALALMCLVSAVGVISCGRPHVVLNSALEEARNVPFGEEVPERLTLPELQWMLSNNELTPVQVEEAPRSRLELVRRDNTVTSKPLNCMNYFWKSRTAC", "function": "Somatostatin inhibits the release of somatotropin.", "AFDB_id": "AF-P01172-F1-model_v4" }, { "swissprot_id": "Q8TGE1", "sequence": "MFNRFNKLQAALALVLYSQSALGQYYTSSSIASNSSTAVSSTSSGSVSISSSIELTSSTSDVSSSLTELTSSFTEVSSSIAPSTSSSEVSSSITSSGSSVSGSSSITSSGSSVSSSSPYDERFNSLDLSVHVSAGFSAGVSVGLEPSATTASVTTTLSPYDERVNLIELGVYVSDMRAHLVEYLLFQAAHSTEPHPTEIAAAFLDHGDFTTRLTGISGDEVTRMITGVPWYSTRLKPAISEALAKDGIYTAIPTSTSTTSDTYISSSSPSQVTSSAEPTTVSGVTSSVEPTRSSQVTSSAEPTTVSEITSSAEPLSSSKATTSAESISSNQITISSELIVSSVITSSSEIPSSIEVLTSSGISSSVEPTSLVGPSSDESISSTESLSATSTPLAVSSTVVTSSTDSVSPNIPFSEISSSPESSTAITSGSSSATESGSSVSGSTSATESGSSASGSSSATESGSSVSGSTSATESGSASSVPSSSGSVTESGSSSSASESSITQSGTASGSSVSSTSGSVTQSGSSVSGSSASSAPGISSSIPQSTSSASTASGSITSGTLTSITSGSSSATESGSSVSGSSSATESGSSVSGSTSATESGSSVSGSTSATESGSSASGSSSATESGSSVSGSTSATESGSSVSGSTSATESGSSASGSSSATESGSASSVPSSSGSVTESGSSSSASESSITQSGTASGSSASSTSGSVTQSGSSVSGSSASSAPGISSSIPQSTSSASTASGSITSGTLTSITSGSSSATESGSSASGSSSATESGSSVSGSTSATESGSSVSGSTSATESGSSASGSSSATESGSSVSGSTSATESGSSASGSSSATESGSASSVPSSSGSVTESGSSSSASESSITQSGTASGSSASSTSGSVTQSGSSVSGSSASSTSGSVTQSGSSVSGSSASSAPGISSSIPQSTSSASTASGSITSGTLTSITSSASSASATASNSLSSSDGTIYLPTTTISGDLTLTGKVIATEGVVVAAGAKLTLLDGDKYSFSADLKVYGDLLVKKSKETYPGTEFDISGENFDVTGNFNAEESAATSASIYSFTPSSFDNSGDISLSLSKSKKGEVTFSPYSNSGAFSFSNAILNGGSVSGLQRRDDTEGSVNNGEINLDNGSTYVIVEPVSGKGTVNIISGNLYLHYPDTFTGQTVVFKGEGVLAVDPTESNTTPIPVVGYTGENQIAITADVTALSYDSATGVLTATQGNSQFSFSIGTGFSSSGFNVSEGTFAGAYAYYLNYGGVVASSATPSSTSTTSGATNSTSGSTSFGASVTGSTASTSFGASVTGSTASTLISGSPSVYTTTLTYATTTSTVVVSCSETTDSNGNVYTITTTVPCSSTTATITSCDETGCHVTTSTGTVATETVSSKSYTTVTVTHCDNNGCNTKTVTSEAPEATTTTVSPKTYTTATVTQCDDNGCSTKTVTSECPEETSATTTSPKSYTTVTVTHCDDNGCNTKTVTSEAPEATTTTVSPKTYTTATVTQCDDNGCSTKTVTSECPEETSATTTSPKSYTTVTVTHCDDNGCNTKTVTSEAPEATTTTVSPKTYTTATVTQCDDNGCSTKTVTSEAPKETSETSETSAAPKTYTTATVTQCDDNGCNVKIITSQIPEATSTVTATSASPKSYTTVTSEGSKATSLTTAISKASSAISTYSKSAAPIKTSTGIIVQSEGIAAGLNANTLNALVGIFVLAFFN", "function": "Involved in cell wall organization and biosynthesis. Confers cell surface hydrophobicity (CSH).", "AFDB_id": "AF-Q8TGE1-F1-model_v4" }, { "swissprot_id": "P81702", "sequence": "VSISYDPIYAADLSMGSVACSNGDHGLMAQYPTLGEVPGFPNVGGIPDIAGWDSPSCGTCWKVTIPNGNSIFIRGVDSGRGGFNVNPTAFTKLVGSTEAGRVDNVNYVQVDLSNCINGAN", "function": "Phytotoxin which causes production of phytoalexin in platanus acerifolia, platanus occidentalis and platanus orientalis. Induces also cell necrosis. Behaves as fungal toxin.", "AFDB_id": "AF-P81702-F1-model_v4" }, { "swissprot_id": "Q6KZB1", "sequence": "MENYNVKTRAFPTIGIILLGGISDKKNRIPLHTTAGIAYTGINNDVYTETKLYVSKDEKCYIDGKEIDLNSDRSPSKVIDKFKHEILMRVNLDDENNLSIDSRNFNILSGSSDSGAAALGECIESIFEYNINIFTFENDLQRISESVGRSLYGGLTVNYANGRESLTEPLLEPEAFNNFTIIGAHFNIDRKPSNEIHENIIKHENYRERIKSAERKAKKLEELSRNANIKGIFELAESDTVEYHKMLHDVGVDIINDRMENLIERVKEMKNNFWNSYIVTGGPNVFVITEKKDVDKAMEGLNDLCDDIRLLKVAGKPQVISKNF", "function": "Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate. Functions in an alternative mevalonate pathway, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate. Also able to catalyze the formation of isobutene via the conversion of 3-hydroxyisovalerate (3-HIV) to an unstable 3-phosphate intermediate that undergoes a spontaneous decarboxylation.", "AFDB_id": "AF-Q6KZB1-F1-model_v4" }, { "swissprot_id": "Q0FPQ4", "sequence": "MKIAEIQLFQHDLPVVNGPYRIASGDVWSLTTTIVKIIAEDGTIGWGETCPVGPTYAEAHAGGALAALEVLASGLAGAEALPLPLHTRMDSLLCGHNYAKSALDIAVHDLWGKRLGVPVHELLGGALTDSVSSYYSLGVMEPDEAARQALEKQREGYSRLQVKLGARPIEIDIEAIRKVWEAVRGTGIALAADGNRGWTTRDALRFSRECPDIPFVMEQPCNSFEDLEAIRPLCHHALYMDEDGTSLNTVITAAATSLVDGFGMKVSRIGGLQHMRAFRDFCAARNLPHTCDDAWGGDIVSAACTHIASTVLPRLMEGAWLAQPYVAEHYDAENGVRIEGGRIRVPQGPGLGLTIDPERFGPPLFSA", "function": "Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. To a lesser extent, can also catalyze the racemization of L-proline betaine.", "AFDB_id": "AF-Q0FPQ4-F1-model_v4" }, { "swissprot_id": "Q0Q2J5", "sequence": "MIQTITHIMIISSLIIFGIALIICLFRLIKGPTTADRVVTFDTTSAVVMSIVGVLSVLMGTVSFLDSIMLIAIISFVSSVSISRFIGGGHVFNGNNKRNL", "function": "Expression of the mnh2 operon in E.coli is not able to catalyze Na(+)Li(+)/H(+) antiport. It does however confer higher growth rates than the control strain at up to pH 9.5. The operon may encode an NADH-ubiquinone oxidoreductase.", "AFDB_id": "AF-Q0Q2J5-F1-model_v4" }, { "swissprot_id": "Q91448", "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSRTKEGVVHGVTTVAEKTKEQVSNVGGAVVTGVTAVAQKTVEGAGNIAAATGLVKKDQLAKQNEEGFLQEGMVNNTGAAVDPDNEAYEMPPEEEYQDYEPEA", "function": "May be involved in neuronal plasticity.", "AFDB_id": "AF-Q91448-F1-model_v4" }, { "swissprot_id": "O75521", "sequence": "MAMAYLAWRLARRSCPSSLQVTSFPVVQLHMNRTAMRASQKDFENSMNQVKLLKKDPGNEVKLKLYALYKQATEGPCNMPKPGVFDLINKAKWDAWNALGSLPKEAARQNYVDLVSSLSPSLESSSQVEPGTDRKSTGFETLVVTSEDGITKIMFNRPKKKNAINTEMYHEIMRALKAASKDDSIITVLTGNGDYYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREFVGCFIDFPKPLIAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKATEMLIFGKKLTAGEACAQGLVTEVFPDSTFQKEVWTRLKAFAKLPPNALRISKEVIRKREREKLHAVNAEECNVLQGRWLSDECTNAVVNFLSRKSKL", "function": "Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.", "AFDB_id": "AF-O75521-F1-model_v4" }, { "swissprot_id": "Q8TGA2", "sequence": "MVIQGKRLAASSIQLLASSLDAKKLCYEYDERQAPGVTQITEEAPTEQPPLSTPPSLPQTPNISPISASKIVIDDVALSRVQIVQALVARKLKTAIAQLPTSKSIKELSGGRSSLQNELVGDIHNEFSSIPDAPEQILLRDFGDANPTVQLGKTSSAAVAKLISSKMPSDFNANAIRAHLANKWGLGPLRQTAVLLYAIASEPPSRLASSSAAEEYWDNVSSMYAESCGITLRPRQDTMNEDAMASSAIDPAVVAEFSKGHRRLGVQQFQALAEYLQIDLSGSQASQSDALVAELQQKVDLWTAEMTPEFLAGISPMLDVKKSRRYGSWWNMARQDVLAFYRRPSYSEFVDDALAFKVFLNRLCNRADEALLNMVRSLSCDAYFKQGSLPGYHAASRLLEQAITSTVADCPKARLILPAVGPHTTITKDGTIEYAEAPRQGVSGPTAYIQSLRQGASFIGLKSADVDTQSNLTDALLDAMCLALHNGISFVGKTFLVTGAGQGSIGAGVVRLLLEGGARVLVTTSREPATTSRYFQQMYDNHGAKFSELRVVPCNLASAQDCEGLIRHVYDPRGLNWDLDAILPFAAASDYSTEMHDIRGQSELGHRLMLVNVFRVLGHIVHCKRDAGVDCHPTQVLLPLSPNHGIFGGDGMYPESKLALESLFHRIRSESWSDQLSICGVRIGWTRSTGLMTAHDIIAETVEEHGIRTFSVAEMALNIAMLLTPDFVAHCEDGPLDADFTGSLGTLGSIPGFLAQLHQKVQLAAEVIRAVQAEDEHERFLSPGTKPTLQAPVAPMHPRSSLRVGYPRLPDYEQEIRPLSPRLERLQDPANAVVVVGYSELGPWGSARLRWEIESQGQWTSAGYVELAWLMNLIRHVNDESYVGWVDTQTGKPVRDGEIQALYGDHIDNHTGIRPIQSTSYNPERMEVLQEVAVEEDLPEFEVSQLTADAMRLRHGANVSIRPSGNPDACHVKLKRGAVILVPKTVPFVWGSCAGELPKGWTPAKYGIPENLIHQVDPVTLYTICCVAEAFYSAGITHPLEVFRHIHLSELGNFIGSSMGGPTKTRQLYRDVYFDHEIPSDVLQDTYLNTPAAWVNMLLLGCTGPIKTPVGACATGVESIDSGYESIMAGKTKMCLVGGYDDLQEEASYGFAQLKATVNVEEEIACGRQPSEMSRPMAESRAGFVEAHGCGVQLLCRGDIALQMGLPIYAVIASSAMAADKIGSSVPAPGQGILSFSRERARSSMISVTSRPSSRSSTSSEVSDKSSLTSITSISNPAPRAQRARSTTDMAPLRAALATWGLTIDDLDVASLHGTSTRGNDLNEPEVIETQMRHLGRTPGRPLWAICQKSVTGHPKAPAAAWMLNGCLQVLDSGLVPGNRNLDTLDEALRSASHLCFPTRTVQLREVKAFLLTSFGFGQKGGQVVGVAPKYFFATLPRPEVEGYYRKVRVRTEAGDRAYAAAVMSQAVVKIQTQNPYDEPDAPRIFLDPLARISQDPSTGQYRFRSDATPALDDDALPPPGEPTELVKGISSAWIEEKVRPHMSPGGTVGVDLVPLASFDAYKNAIFVERNYTVRERDWAEKSADVRAAYASRWCAKEAVFKCLQTHSQGAGAAMKEIEIEHGGNGAPKVKLRGAAQTAARQRGLEGVQLSISYGDDAVIAVALGLMSGAS", "function": "Fatty acid synthase alpha subunit; part of the gene cluster that mediates the biosynthesis of aflatoxins, a group of polyketide-derived furanocoumarins, and part of the most toxic and carcinogenic compounds among the known mycotoxins. The four major aflatoxins produced by A.parasiticus are aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits aflA and aflB, as well as the PKS aflC. AflC combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by the fungal fatty acid synthase aflA/aflB. The second step is the conversion of NOR to averantin (AVN) and requires the norsolorinic acid ketoreductase aflD, which catalyzes the dehydration of norsolorinic acid to form (1'S)-averantin. The norsolorinic acid reductases aflE and aflF may also play a role in the conversion of NOR to AVN. The cytochrome P450 monooxygenase aflG then catalyzes the hydroxylation of AVN to 5'hydroxyaverantin (HAVN). The next step is performed by the 5'-hydroxyaverantin dehydrogenase aflH that transforms HAVN to 5'-oxoaverantin (OAVN) which is further converted to averufin (AVF) by aflK that plays a dual role in the pathway, as a 5'-oxoaverantin cyclase that mediates conversion of 5'-oxoaverantin, as well as a versicolorin B synthase in a later step in the pathway. The averufin oxidase aflI catalyzes the conversion of AVF to versiconal hemiacetal acetate (VHA). VHA is then the substrate for the versiconal hemiacetal acetate esterase aflJ to yield versiconal (VAL). Versicolorin B synthase aflK then converts VAL to versicolorin B (VERB) by closing the bisfuran ring of aflatoxin which is required for DNA-binding, thus giving to aflatoxin its activity as a mutagen. Then, the activity of the versicolorin B desaturase aflL leads to versicolorin A (VERA). A branch point starts from VERB since it can also be converted to dihydrodemethylsterigmatocystin (DMDHST), probably also by aflL, VERA being a precursor for aflatoxins B1 and G1, and DMDHST for aflatoxins B2 and G2. Next, the versicolorin reductase aflM and the cytochrome P450 monooxygenase aflN are involved in conversion of VERA to demethylsterigmatocystin (DMST). AflX and aflY seem also involved in this step, through probable aflX-mediated epoxide ring-opening step following versicolorin A oxidation and aflY-mediated Baeyer-Villiger oxidation required for the formation of the xanthone ring. The methyltransferase aflO then leads to the modification of DMST to sterigmatocystin (ST), and of DMDHST to dihydrosterigmatocystin (DHST). Both ST and DHST are then substrates of the O-methyltransferase aflP to yield O-methylsterigmatocystin (OMST) and dihydro-O-methylsterigmatocystin (DHOMST), respectively. Finally OMST is converted to aflatoxins B1 and G1, and DHOMST to aflatoxins B2 and G2, via the action of several enzymes including O-methylsterigmatocystin oxidoreductase aflQ, the cytochrome P450 monooxygenase aflU, but also the NADH-dependent flavin oxidoreductase nadA which is specifically required for the synthesis of AFG1.", "AFDB_id": "AF-Q8TGA2-F1-model_v4" }, { "swissprot_id": "P22751", "sequence": "MKYAASGLLSVALNSLLLLGSNQRFATQDVAPVWRGIAFGQSTDVNFATNVLPEKVGVNDVTINGKKLTVNDKADLSAPITIESRGGKIANTHDGLTFFYTQLPANVNFTLQSDVTVEQFGPESDAKPNAQEGAGLLVRDILGVPRQEPLKEGYEEFPAASNMVMNAIMTQDKKSKTEVKMQLISRNGVTQPWGNTNAEITRTSYQEKINLEQTPTFRLKLERTNDGFITAYAPKGSDQWVSKTVKGADLVTHQDKDHYYVGFFASRNAKITISNASLTTSPANTKPSAPFKAETTAPLLQVASSSLSTSDTYPVQARVNYNGTVEVFQNGKSLGKPQRVRAGDDFSLTTRLTQQKSDFKLVYIPSEGEDKTAKETSFSVEKITLADARNLYVSPEGKAGNDGSKNAPLDIKTAINALPGGGTLWLMDGDYSATVIPVSATQRKGMKTLMPVGKKAVFHGLQLNASYWKVKGIEITEKSFRIEGSHNQIERLLAHHCDNTGIQVSSSDNVGRPLWASHNLILNSESHSNQHPSKKDADGFAVKMRVGEGNVIRGAFSHDNVDDGFDLFNKIEDGPNGAVMIENSISLNNTSNGFKLGGEGQPVAHQVKNSIAIGNHMDGFSDNFNPGALQVSNNIALDNVRFNFIFRPSPYYGYEKQGIFKNNVSLRTQPGKYDDAVVGRLDASNYFIRIIERSTVRVRKSRRRITNPSRCQRSSAGMKKAACNWVIFCRRSNRHKTQRHRNRYPSTPA", "function": "Exo-cleaving lyase that catalyzes the digestion of pectate. Contributes to pectate catabolism but not to bacterial virulence. In vitro can also use citrus pectin and highly methyl-esterified Link pectin as substrates.", "AFDB_id": "AF-P22751-F1-model_v4" }, { "swissprot_id": "B0BNF0", "sequence": "MPCCDPYPWIGLNVGRLSSFPLLKYPQVRRWLAPFIVACSLYFLLWIPEDQPSWVSALVKCQPILCLVLFLWAVAPGGSYTWLLQGALTCSAVGDACLIWPEAFFYGMAVFSVAHLLYLWAFGLSPLQPGLLLCTTLASLTYYSFLLLHLEPNMVLPVAAYGLILNTMLWRGLVLGRSAGWGAVLFIFSDGVLAWDTFVYTLPFARLVTMSTYYAAQLLLTLSALRSPGLKTH", "function": "Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.", "AFDB_id": "AF-B0BNF0-F1-model_v4" }, { "swissprot_id": "Q9SWQ9", "sequence": "MKSKRQALSPLQLMEQTYDVVNFHPGGAEIIENYQGRDATDAFMVMHFQEAFDKLKRMPKINPSFELPPQAAVNEAQEDFRKLREELIATGMFDASPLWYSYKISTTLGLGVLGYFLMVQYQMYFIGAVLLGMHYQQMGWLSHDICHHQTFKNRNWNNLVGLVFGNGLQGFSVTCWKDRHNAHHSATNVQGHDPDIDNLPPLAWSEDDVTRASPISRKLIQFQQYYFLVICILLRFIWCFQCVLTVRSLKDRDNQFYRSQYKKEAIGLALHWTLKALFHLFFMPSILTSLLVFFVSELVGGFGIAIVVFMNHYPLEKIGDPVWDGHGFSVGQIHETMNIRRGIITDWFFGGLNYQIEHHLWPTLPRHNLTAVSYQVEQLCQKHNLPYRNPLPHEGLVILLRYLAVFARMAEKQPAGKAL", "function": "Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in 20-carbon chain length fatty acids (C20) that have an existing delta-11 unsaturation (double bond). Whether it acts on CoA-linked substrates (as in animals) or phospholipid-linked substrates (as in plants and fungi) is still not clear (Probable).", "AFDB_id": "AF-Q9SWQ9-F1-model_v4" }, { "swissprot_id": "Q8MRW5", "sequence": "MTISWRALSHFLIPQSDYGEAKTHLEQLQQTLTHLDHPHHHHAHHPHHHLGLYHGALPNTSTITTDSVVSCVSSTLPAVAKAISASSSCDGLQSERKKCPISDLDSGGHGHGQGHGLMEAICAGQKTSPIPPPPPPCCLTLGESSSSPNPIATAALMNASTSGSSSAGGASASLCNDLTRESSWYAHHHHHHHHHHHQLPDELVMYATPTPTPAIGKFGLDTSTEGYLNARYNVNVKGVRHDRTSSFFDIPAVTHPHNHPHPHPHPHPHPYCYRFPSSPPAGILKKSDEEATSAAVYCSDVSSGQHFPHHTKIEHADSTTTAAQQQQQQQEQQQQQQQQQQQQQHQQQLQQAAALHPHHHHSHHGHHGHQQAEQQALTHLTPLHAASAFKFSHTAVISSSAVYATPSHYAHQQQTQSQSVYRDLSPTTLAAVSDADLKYDSGPYNAAISSTYPSALRPNVVDSTTSSDAELRLDQFYASNGISTSSNGQAISQRRGSLQLWQFLVALLDEPTTSASCIAWTGRGMEFKLIEPEEVARRWGLQKNRPAMNYDKLSRSLRYYYEKGIMQKVNGERYVYRFVCDPDALFNMAYGHLTTGSGKGDQHQLTLSLAKTPPTSGDSQTQSPRVAKSEYYDTAALHKY", "function": "Required in dopaminergic neurons to regulate expression of genes involved in dopamine signaling. Decreases expression of the dopamine transporter DAT and increases expression of the dopamine transporter Vmat and the tyrosine 3-monooxygenase ple which is involved in dopamine biosynthesis. Also involved in negatively regulating the expression of a group of endoplasmic reticulum proteins, the molecular chaperone Calr and the protein disulfide isomerases CaBP1 and ERp60.", "AFDB_id": "AF-Q8MRW5-F1-model_v4" }, { "swissprot_id": "Q6AWY8", "sequence": "MMMMSGRPSGGAGGGRYPFTASQWQELEHQALIYKYMASGTPIPSDLILPLRRSFLLDSALATSPSLAFPPQPSLGWGCFGMGFGRKAEDPEPGRCRRTDGKKWRCSKEAYPDSKYCEKHMHRGKNRSRKPVEMSLATPPPPSSSATSAASNTSAGVAPTTTTTSSPAPSYSRPAPHDAAPYQALYGGPYAAATARTPAAAAYHAQVSPFHLQLDTTHPHPPPSYYSMDHKEYAYGHATKEVHGEHAFFSDGTEREHHHAAAGHGQWQFKQLGMEPKQSTTPLFPGAGYGHTAASPYAIDLSKEDDDEKERRQQQQQQQQQHCFLLGADLRLEKPAGHDHAAAAQKPLRHFFDEWPHEKNSKGSWMGLEGETQLSMSIPMAANDLPITTTSRYHNDD", "function": "Transcription activator that plays a regulatory role in gibberellin-induced stem elongation.", "AFDB_id": "AF-Q6AWY8-F1-model_v4" }, { "swissprot_id": "P43463", "sequence": "MYNKLPISYSRKHTQFQSSIISEILVWIEGNLTNRLSLDDIAQHSGYTKWHLQRVFRKIVGMPLGEYIRRRRICEAAKELQTTNLQVIDIALKYQFDSQQSFAKRFKAYLGISPSLYRLSDTGYNDLLLLEPKVA", "function": "Transcriptional activator of 2'-N-acetyltransferase.", "AFDB_id": "AF-P43463-F1-model_v4" }, { "swissprot_id": "C5H8E7", "sequence": "MASTLKLFMLLPVILLLLQEAYGTIDVEARGDNFNCNKREGPCSQRSLCECDPNLQLGRHSDQLWHYNLRTNRCERGGYRDNCNSHTSSGACVMACER", "function": "Activates large conductance calcium-activated potassium channels (maxiK, KCNMA1/KCNMB), when tested at micromolar concentrations, suggesting a potential mechanism for regulating host blood supply during feeding. Shows no antiprotease activity, and does not prevent ADP-, PAF- or collagen-induced platelet aggregation. Has no effect on blood coagulation and does not inhibit the alternative or classical complement cascades.", "AFDB_id": "AF-C5H8E7-F1-model_v4" }, { "swissprot_id": "Q9VEV4", "sequence": "MFRSRSWFGGPWGGRPKNRLSLEHLKYLYSILEKNTTVSESNRGLLVESLRCIAEILIWGDQHDSLVFDFFLEKNMLSYFLHIMRQKSGGSSFVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIMVHKFDFSDEDVMGYYILFLKTLSLKLNTHTIHFFYNEHTNDFPLYTEAIKFFNHPESMVRIAVRTISLNVYKVQNPSMLRFIRDKTAAPYFSNLVWFIGKHILELDTCVRTDIDHQSNQKLSNLVAEHLDHLHYLSDILLLEIKDLNAVLTEHLLHKLFVPLYIFSLTPAPPPPSLAVVTQNLAAVLNRNVDIDIQEMHNPRVSSIVALFLLSLVFLVVSHAPLVHALAWVILNGDHSVFKEGAAEILNSYVEHREVVVPGFGEPDESLEQALDTVTGQSSSSSYALSEDSGVESSSPATTELDSQADAVEAEQIKLRNITDEEKQLLQKSSSSTKADFAEMAKPFLDTVLHALDCTENDYLALLSLCLIYAMSHNRGIKNEWFEQVLAKSTRGAFSYKTALIEHLLNIITQSSQPSSRIRLITVEIALELLVTFTRPSSDDSRCITAAQQDLLFSARNQSMVVIRNFYKSEDIFLDLFEDEYNEMRKAQLNVEFLCMDSTILLPPTGTPLTGINFTRRLPCGEVEKARRAIRVYFLLRRTCQKFLNEKESLLPLTNVVNLVQVENVLDLNNSDLIACTVVAKDSSKQRRFLVIDALQLILVEPDAKLLGWGVAKFVGFLQDVEVQGDKDDSRCLHITVHRGGVTHNRTPLLSAKFLFDDHIRCMAAKQRLTKGRSKARQKKMYQIAQLIEIPGQMDSPVYAVGGTMVASSSGGSGNSSGSSSRSSHHRPMFSTANRVPGFAAVLRGSNSAGVSRTQMAPNRSIEGIRNESAGRSRRRSPSSTSGSNLRADHSDRERSPSVSMGSHSSSQSRENSQPRSTGNRSRESSPRMPRPRSEEIPLEDFQHSRNNSPHSRGNPSPASRSHTPIRVLHYDQLSGHSGSPREASLGGTNALLSQLNGLNREVLPTQSSEETSFIGSDGNEATGGSEGRRRGAIETV", "function": "Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways. Required for endosome trafficking and maturation. Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes. In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy. Essential for the recruitment of lva-positive Golgi elements to autophagosomes. Likely to function by promoting membrane traffic from the Golgi complex to the developing autophagosomes. Also regulates synaptic growth at the neuromuscular junctions (NMJ) by down-regulating BMP signaling.", "AFDB_id": "AF-Q9VEV4-F1-model_v4" }, { "swissprot_id": "Q9FNP4", "sequence": "MLQEPSAAFSLRRNSFRRRSPRSNVDDRGWNPLHIKARKGDLKSVKQLLDQGMDVNALAWGPKSKGVSALHLAAEGGHIEVMDLLLERGANIDAKTWGSCGWTPLHAAAKERKREAVKFLVENGAFLADDITDTRFNPPVHYCHGLEWAYEEMKKLNSESSSSSGGDTSSSSDN", "function": "Promotes anthocyanin accumulation through interaction with PHYA, especially in response to far-red light, high light and sucrose treatment, probably by triggering A3G2XYLT/UF3GT expression. Required for gametophytes development as well as male-female gamete recognition during fertilization, possibly by regulating mitochondrial gene expression. Represses PHYA-mediated PIF3 phosphorylation.", "AFDB_id": "AF-Q9FNP4-F1-model_v4" }, { "swissprot_id": "Q10951", "sequence": "MTEVECWDDDPDFASDVDNASLFTQSIATTSASTSVDDGFSFDDSISRLNSLSISDVPSAHSRVEQWNQQVHNLNHELSSNKNRISSNVEGYEDDFSFDEEGEEGNNEFNTLRPNKYQDADVDEFNTIRASETASQRPPIPFSSDTLKKTYLSSENDARYPSVSDSPYCESEGFSSFEDDFEIDPDTDLNSILHRKQNRMDPKASFSSVEQSSLRTPSSAHNDDGFWDDFDIDFNNETESIFRKKIRSPNTINQKHPYISSTISYQPNVHQDAKYYPLCKDIFPSLANENPHSDNPNLKYSSKTLSKRDTSSHYPETLKASSKHSSPVKGNSSISSTWTPSNLKIYHSKNSMGLMDLDALKTVASNSKYRTKPKNCKTYGDGTELDTLDELPVDYEFELKLRKKQTTKVSGTPKSKHAGSTQEWHSHTTPRSTSKHENNLNNITNSAKNEHIRSQRQHKTHAAPSKELTKESLSNDQLSVKEKRRHHKKAPTLIQNLNSPRTPKIVGKMRYNPTKHCWEGNDYAIRDFDTPISPSRPALISNISTKKGIQVVGNMVYDPTRLRWIDNSISGQEAEDPFSGFDDLEDTDSTSQYLNENSGSFNGSINSIINFPDMSEIYDVGPEFEKKQFSEDIQWRKRIDGWFFSFKNDDRSRLWELYNILNAEQ", "function": "Has an essential role in ensuring cytokinesis and septation occur only once during mitosis. It does so by interacting with the ras1 signaling pathways, thereby suppressing them.", "AFDB_id": "AF-Q10951-F1-model_v4" }, { "swissprot_id": "A1AN86", "sequence": "MQVNVETISPVSKKVSIEIPADQVNSEIEKTYATIQKRAKIQGFRPGKAPLQLIKRTYADSMRDEVMRRFYETTLFKTLAEHKIEPIDAPTVECDILEEGTPFKYSALVEVMPEVLLTQYTGLEITKERYVFDPQKIEDEIARMRDGMAQLVPVEGDVAVEMGHMVTIDYAFSVDGFPEESTSAENAVVEVGAHRLLPEFEDQLVGMKCGESKHVTVTLPEAYRNPEVAGKEGAFMVTLNEIKRKELPELNDEFAQQFGEFETVEQLREKMTEYHQQHEQDRIEQEQRETVIQALIEKNPLDVPQSMVKRQVEQMLQNLKNRLKSRNMSMEMMGMDDDSFRERVRDSATDKVRGGLLLMALIEKEDFSVSDEEIEKRYEKLAGGNEEMLERIKEHYTSSPSVRHSLIAEIKEDKAVRFLLDNAVITETDPAETAAEA", "function": "Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.", "AFDB_id": "AF-A1AN86-F1-model_v4" }, { "swissprot_id": "Q11X87", "sequence": "MARILAFDFGTKRIGIASTDPMQIIANALDTVHPKDVVVYLKKYLNTEPVEAFVVGLPRTLQNEESSNAANVKAFINLIKKNFPQTPIYGVDERFTSSMAFDTMLAGGVSKKGRRDKATIDKISATIILQSFMEQKQNGTATMIFKPDDANS", "function": "Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.", "AFDB_id": "AF-Q11X87-F1-model_v4" }, { "swissprot_id": "O52513", "sequence": "MRKPSSGQPAGLDAWDETRSLATHAGPDFALYVGDSLDCLAKLPDESINTVVTSPPYWAVRDYEHDEQLGLEDEVDDYVERLVKIFREVYRVLATDGSAWLNIGDSYFNKQITVGGKPPRTGWKRNKQLSLVPFRVALALQDDGWWIRNVAVWHKPNAMPASVRDRLTVTWEPVFLLTKSERYYFNLDEIRVPHQTSDAIERRRAESGTVTGKAQGKKELRKWLNSPRHRATIEGIKEVERRPNAPAAVELASYLRTALKEKKRSIAWVAEQLDLPFERTRHYFRTDEIGSRLPPPEVWEQLKDLLELDATYDEAMTVEVGDNVFRNHPNGKNPGDLLSIPTAPSGANHFAVMPRKLAHFALKATLPMNGSCLDPFMGSGTTGRVVRELGGRFVGVDVNEHYMTDYLVESGVISPETETLW", "function": "A beta subtype methylase, recognizes the double-stranded sequence 5'-GGCCNNNNNGGCC-3', methylates C-? on both strands, and protects the DNA from cleavage by the SfiI endonuclease.", "AFDB_id": "AF-O52513-F1-model_v4" }, { "swissprot_id": "Q92567", "sequence": "MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYATLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAPPPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAIYPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYVPPHW", "function": "In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.", "AFDB_id": "AF-Q92567-F1-model_v4" }, { "swissprot_id": "P08701", "sequence": "MNRKYYFNNMWWGWVTGGYMLYMSWDYEFKYRLLFWCISLCGMVLYPVAKWYIEDTALKFTRPDFWNSGFFADTPGKMGLLAVYTGTVFILSLPLSMIYILSVIIKRLSVR", "function": "This protein is able to protect a cell, which harbors the plasmid ColIa-CA53 encoding colicin Ia, against colicin Ia.", "AFDB_id": "AF-P08701-F1-model_v4" }, { "swissprot_id": "Q86W92", "sequence": "MMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKLLTSSLQKSSSLGNLKKETSDGEKETIQKTSEDRAPAESRPFGTLPPRPPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLAETEKETAEHLDLAGASSRPKDSQRNSPFQIPPPSPDSKKKSRGIMKLFGKLRRSQSTTFNPDDMSEPEFKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTKEQVCNWLMEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEETNHGKLDFNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLAFSNFGNLRKKKQEDGEEYVCPMELGQASGSASKKGFKPGLDMRLYEEDDLDRLEQMEDSEGTVRQIGAFSEGINNLTHMLKEDDMFKDFAARSPSASITDEDSNV", "function": "May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.", "AFDB_id": "AF-Q86W92-F1-model_v4" }, { "swissprot_id": "Q96502", "sequence": "MLKEESNESGTWARACDTCRSAACTVYCEADSAYLCTTCDARVHAANRVASRHERVRVCQSCESAPAAFLCKADAASLCTACDAEIHSANPLARRHQRVPILPLSANSCSSMAPSETDADNDEDDREVASWLLPNPGKNIGNQNNGFLFGVEYLDLVDYSSSMDNQFEDNQYTHYQRSFGGDGVVPLQVEESTSHLQQSQQNFQLGINYGFSSGAHYNNNSLKDLNHSASVSSMDISVVPESTASDITVQHPRTTKETIDQLSGPPTQVVQQLTPMEREARVLRYREKKKTRKFDKTIRYASRKAYAEIRPRIKGRFAKRIETEAEAEEIFSTSLMSETGYGIVPSF", "function": "Putative transcription factor. Does not affect flowering time.", "AFDB_id": "AF-Q96502-F1-model_v4" }, { "swissprot_id": "Q40902", "sequence": "MMTEVHDAGRPRVVIFNGSQLQREAIIPFASRSSCFHHQLCSRGHLLIIFLLLVSPFNDAAVDVDGDDNDNLIIDHVPDAKSSSEALLNFKSSLSTSSPRGHEVLGSWIPSNSPCSGNNGNWLGVLCYEGDVWGLQLENLDLSGVIDIDSLLPLHFLRTLSFMNNSFKGQCLIGISLEPSSHCTCPIIASPVRSRMMLPGYDLSQEALFGKQPIQRQHPHLPGYLLPQVFELSLENNRFTGSIPHFPPNVLKVLNLSNNQLEGPIPPALSLMDPTTFSGNKGLCGKPLESACNSPSQEANNPDSRNSSTISGQSSTDVIRKSPTRLSKVMLIVAVCLVVLCLLIVLILIIRRRSHSSSQNPQPVESNYSNNDRDQNAFTSSAPDDHVTLSGNSTYSNNQHSNSNKAEAPTAAVVGKLSFVRDDRPRFDLQDLLRASAEVLGSGNLGSSYKALLMDGQAVVVKRFKQMNHVAKEDFHEHMRRLGRLTHPNLLPLVAYYYRKEEKLLVYDYASNGSLASHLHGNQSRLDWSSRLKIVKGVAKALAYLHNELPSLALPHGHLKSSNVLLDKYLNPVLMDYTLVPLVNLAQVQHLLVAYKAPEYAQQGRITRKTDVWSLGILILETLTGKFPTNYLALSTGYGTELATWVDTIIRDNESAFDKEMNTTKDSQGQIRKLFDIGVACCQEDLDTRWDLKEVVQSIQSLNDKDHGHSNSDQMHDAGV", "function": "Dual-specificity kinase with both serine/threonine and tyrosine kinase activities. Required for postmeiotic development of microspores (Ref.2). Involved in embryo sac development at the late stages of megagametogenesis (Ref.3). Involved in the phosphorylation of KIP1.", "AFDB_id": "AF-Q40902-F1-model_v4" }, { "swissprot_id": "A0JMA9", "sequence": "MELSYQALRVASQNREAEELRTEARRKNLLILIMHYLLQEGYMDSANSLEQETKISLRRFDVCDNVDLETILMEYESYYYIKFQKYPKITKKALDHDSRVQSKPRSAGKLRRAGSNSTQGLPRIAQQTVLHRPVSGSYFRTHAHQKALSRENSKQENGGNSPREASEIGLNVSAISKTSGEGGQTRRRQVIDFRSMIQDTIKGASQEIALNSLNCNPDPSERLIKPVGAFIGGNSEMRELAAVISRDIYLQNPNVRWDDIIGLDAAKRLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECNTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTGPGGEHEGSRRMKTELLVQMDGLARSDDLVFVLAASNLPWELDYAMLRRLEKRILVDLPSKEARQAMIQHWLPPVSNSSGVELRTDLDYSTLGAETDGYSGSDIRLVCKEAAMRPVRKIFDALENHHSEHKNLPVISLDTVTTSDFLEVLAHTKPSAKSLAEKYAAWQKEFESV", "function": "Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.", "AFDB_id": "AF-A0JMA9-F1-model_v4" }, { "swissprot_id": "Q5EBI0", "sequence": "MSGPLASGTCSDPEEVSDLKSPLSSRFREPLTHARFQELFGGAEPEPELPAEPCLPCLCRLRRRRASACSGPGAWRVLLARLPPLRWLPQYRWRAWLLGDAVAGVTVGVVHVPQGMAFALLTSVPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAVLSLMTGSVVERVVPEPLAGNLSGIEREQLEARRVGAAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVIKALTSGAALHVLVSQLPSLLGLSLPRQIGCFSLFKTLAAVLSALSQSSPAEVTISALSLVLLVPVKELNVRFRDRLLTPIPGEVVMVLLATVLCFTSSLDTRYNVQVVGPLPGGFPQPLLPTLDELPRILADSLPISLVTFAVSTSLASIYADKYSYTIEPNQELLAHGVSNLISSLFSCFPNSATLATTSLLVDAGGNTQLAGLFSCAVVLAALLWLRPFFYYLPKAVLACINISSMRQMFFQMQELPQLWHISHVDFAVWIVTWVAVVTLNVDLGLAVGVVVSMMTVVCRTQRVQCLELGLAEGTELYRPIRESRKLLQVPGLCILSYPAPLYFATRGQFHRILEWHLGLGERIKPGAEPVRVAILDFSGITFVDAAGAREVVQLTRRCQDDGIYLLLAQCNALVLETLTRARLLDSVSPEQLFVSVQDAAAHALERLKPTGPKICTVWV", "function": "Chloride/bicarbonate exchanger.", "AFDB_id": "AF-Q5EBI0-F1-model_v4" }, { "swissprot_id": "Q5MJ70", "sequence": "MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPKGPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATPVDCSLCGKKRRYVRLGLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLKKDKSMEWFTGSEE", "function": "Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Mediates cell survival during the DNA damage process through activation of CDK2.", "AFDB_id": "AF-Q5MJ70-F1-model_v4" }, { "swissprot_id": "O31623", "sequence": "MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDADGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIAGLAGIIETLVSKWLQE", "function": "Involved in sporulation.", "AFDB_id": "AF-O31623-F1-model_v4" }, { "swissprot_id": "Q9I742", "sequence": "MSEISRVALFGKLNSLAYKAIEAATVFCKLRGNPYVELVHWFHQILQLPDSDLHQIVRQSGIDPARLAKDLTEALDRLPRGSTSITDLSSHVEEAVERGWVYGSLMFGESQVRTGYLVIGILKTPSLRHALTGLSAEFAKLKVEALTERFDEYVGASPENGLSASDGFNAGAAPGEASGALAPSAMGKQEALKRFTVDLTEQARSGKLDPIVGRDEEIRQLVDILMRRRQNNPILTGEAGVGKTAVVEGFALRIVAGDVPPALKDVELRALDVGLLQAGASMKGEFEQRLRQVIEDVQSSEKPIILFIDEAHTLVGAGGAAGTGDAANLLKPALARGTLRTVAATTWAEYKKHIEKDPALTRRFQVVQVDEPSEHKAILMMRGVASTMEKHHQVQILDEALEAAVRLSHRYIPARQLPDKSVSLLDTACARTAISLHAVPAEVDDSRRRIEALETELAIIRRESAIGVATAERQRNAETLLAEERERLAALEQRWAEEKRLVDELLETRARLRAAAEAVDAGGVPLGEGEVRLDEEQRQALHARLAELQAQLSALQGEEPLILPTVDYQAVASVVADWTGIPVGRMARNEIETVLNLDRHLKKRIIGQDHALEMIAKRIQTSRAGLDNPSKPIGVFMLAGTSGVGKTETALALAEAMYGGEQNVITINMSEFQEAHTVSTLKGAPPGYIGYGEGGVLTEAVRRKPYSVVLLDEVEKAHPDVHEIFFQVFDKGVMEDGEGRVIDFKNTLILLTTNAGTEMIASLCADPELMPEPEAIAKSLREPLLKIFPPALLGRLVTIPYYPLSDDMLKAISRLQLGRIKKRVEATHKVPFEFDEGVVDLIVSRCTETESGGRMIDAILTNTLLPDMSREFLTRMLEGKPLAGVRISSRDNQFHYDFAEAE", "function": "Component of the H1 type VI (H1-T6SS) secretion system that plays a role in the release of toxins targeting both eukaryotic and prokaryotic species. Acts as an AAA(+) ATPase that disassembles the contracted sheath, which resets the systems for reassembly of an extended sheath that is ready to fire again.", "AFDB_id": "AF-Q9I742-F1-model_v4" }, { "swissprot_id": "P48516", "sequence": "MIREQRSSRGGSRDQRTNRRIRAREVRVVGSDGSQLGVMPLEAALDRARTEGLDLVEISPMASPPVCKIMDYGKFKYEEKKKASEAKRAQVTVLLKEVKLRPKTEEHDYEFKVRNTRRFIEDGNKAKVVIQFRGREITHREQGTAILDDVAKDLKDVAVVEQMPRMEGRLMFMILAPTPKVAQKARELVRQAATAAKRPPPPGAPGAGKSAAGASSGAEEKAEETAEEKKEAQAAPAAAEAQSPTAS", "function": "IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.", "AFDB_id": "AF-P48516-F1-model_v4" }, { "swissprot_id": "Q52185", "sequence": "MSKTIPIVDAQHAGSAYQHVPGHPDPQLSAVAKGTPTGEYLRRYWQPVALSADVTDRPQMVRILGEDLVLFRDKAGRPGLLYPRCMHRGTSLYYGHVEEAGIRCCYHGWLFAVDGTCLNQPCEPEGGLRREAARQPWYPVEERYGLVFAYMGPPEKKPVLPRYDILEDLEEGEFIEVISGGFVSYADHVEDPNVPYHWLQNWENIMDPYHVYILHSTFSGIQFAENFKILPRVDFEAVDGGVIYHAWRDLEDGRQLERINSALFPNISAIPMIDLSPGQGRWIGWHVAVDDQHYRGFFAARTRQPGNFAPIKMHNGKSWTELSEQEKQDFPGDFEAQFGQGRVTLHGEEHLATSDHGIALLRRQMKQQIAIVQQGGDPAGVHFNEADALVRIRSGNFYTTSDKTETAAD", "function": "Degrades exclusively diarylether compounds having carboxyl groups in the 3- or 4-position. Yields a hemiacetal that spontaneously hydrolyzes to phenol and protocatechuate.", "AFDB_id": "AF-Q52185-F1-model_v4" }, { "swissprot_id": "Q27902", "sequence": "MLTIFIVTATLFAILYFYFTRNFNYWKDRNVVGPEPTVFFGNIMESVIRRKHLIMIYKDIYEAFPKEKVVGIYRMTTPCLLLRDLDVIKHVMIKDFDLFNDRGVEFSEEGLGLNIFHADGDRWRVLRQCFTPLFTSGKLKNMLNLMSDRGDKFIKMVEKFCDKEPEQQIIPLVRKFTMASITTCAFGMELDEEMIETLDKLDSLIFTTSYGNEIDMMYPGILKKLNSSIFSKMIAPFFDNLTKTIIEQRGGKPTNRKDLMDLILELRQKKAIEPMKKTHDEQVTTLELTDSVIAAQTFIFYAAGYETSASTMSFLLFELAENPDIQEKVIAEVDETLKRHNGEITYDTLSEMTYLTQVFHETLRKYPVADILLRNAKADYAVPGTNVTLKKGQTVVVSGFGIHYDPKYYPDPEKFDPERFSPENVRNRHPCAYIPFGAGQRKCLGMRFGQWQVQVCIIKLLSKFRFEPSTKTMSEFNYDPKRLLVYPKSGIFLNIIPRNY", "function": "Enables the insect to feed on furanocoumarin-producing plants and evolved as an adaptation for detoxification of xanthotoxin and other furanocoumarins. This isozyme metabolizes isopimpinellin, imperatorin, and bergapten at high rates, xanthotoxin and psoralen at intermediate rates and angelicin, sphondin, and trioxsalen only at very low rates.", "AFDB_id": "AF-Q27902-F1-model_v4" }, { "swissprot_id": "Q64726", "sequence": "MVPVLLSLPLLLGPAVFQETGSYYLTFLYTGLSRPSKGFPRFQATAFLNDQAFFHYNSNSGKAEPVGPWSQVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYKDTTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPEMLKRYLNYSRSHLDRIDPPTVTITSRVIPGGNRIFKCLAYGFYPQRISLHWNKANKKLAFEPERGVFPNGNGTYLSWAEVEVSPQDIDPFFCLIDHRGFSQSLSVQWDRTRKVKDENNVVAQPQ", "function": "Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.", "AFDB_id": "AF-Q64726-F1-model_v4" }, { "swissprot_id": "G5EB89", "sequence": "MAERYIPEHRRTQYKARNQFRPDELRRRREEQQVEIRKQKREENLAKRRGIQTRDGGIGVGGGMAAAESDDEASAIESELNVELPEMVKGVFSDQIEAQIQATTKFRKLLSKERNPPIERVIETGVVSRFVEFLRSPHTLVQFEAAWALTNIASGSAQQTQVVIEAGAVPIFVELLSSPEPDVREQAVWALGNIAGDSPQCRDFVLNAGALRPLLTLINDGRKISMLRNATWTLSNFCRGKTPQPDWNTIAPALPVLAKLIYMLDDEVLIDACWAISYLSDGPNEKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVIINCGALPALLSLLSSTKDGIRKEACWTISNITAGNSSQIQSVIDAGIIPPLVHLLANGDFKTRKEACWAISNATSGGLQKPDQIRYLVTQGCIKPLCDLLACPDNKIIQVALDGLENILKVGEMDKEAGQGDAHVNRYALFIEEAGGMEKIHDCQNNANEEIYMKAYNIIEKYFSDEDEAAGDIDELAPQQTQTGFTLGATQQQPGGFSFGGANGGDSMDM", "function": "Import of proteins with classical NLS composed of one or two clusters of basic residues is initiated by binding to the importin alpha/beta heterodimer, where importin alpha acts as an adapter subunit to bridge NLS cargos to importin beta, which transports the whole complex through the nuclear envelope. Involved in the nuclear accumulation of the light-dependent developmental regulator veA. Participates at different regulatory stages of asexual and sexual development, being required for the completion of both reproductive cycles with the formation of conidiospores and ascospores, respectively. Mediates secondary metabolite gene expression with positive regulation of penicillin production and negative regulation of mycotoxin biosynthesis.", "AFDB_id": "AF-G5EB89-F1-model_v4" }, { "swissprot_id": "P39531", "sequence": "MDDLLKVPEIVTNIASYLSTVDYLSFQQVNKRVYAIINGKNDSKYWSLKLTRMGLQQVHSNEEEEITLLDENDNQNSLRIFEIYKSFTAQNSKKIFVKFYRCYNSYARKLYNNNLANFFPTSYSNDPLKQTRILNFIKKYNFSNKNDIETFTRIETNFNILREIFINSVLKESELNYQSNNLAAVARFMKILLISNEESNAIEFFKSKADLPPSLTVLPSNDELFWAEQPREEDSGGSTVIFNSKNLDTFLNQLRDFLNEKIKLADILFKDEFPVILQFIESFIQDILLDILNNILLSYSEFLKENGKDSKANYECVPELYFTFIKKFDTELNDSVNAGANFRKVVRDLLNLYLEPFVVNYMNQTTRVFESLINSQLANYDTQVQDKQREQNAKIYNTLKDQTDASSASNNELPNDLSIITETSKTVPEADSKPSTIHQSVHSTDISNDKLDFLSSFTKIFKFSNNENQRLKQQLQLAYNLNLISNNLQNIKSLISLDLCYKILQETSEKTDQIYKFHTIESLLPLIKLRCQEIFKILITQLNKNHVKPAFEKAILLLQKYNPNEIEQIEIKFNSLSPANTQVEPLVQFTELINIGDIILQMISIFYKNELIPKKIIDKNKDFLNDVIQLKKNFETSIDDFVAEGLNIGINKLMDEISFVFKTLQLPDDYNPPPPSRNSPIRDIKPTKCAIRVVELLSNHCFLLTGATDKGTIDVYQQEIGERFFNEIVKHLKKCFISTEGAIWLICDLNYFYDFIANKLKQKNVVPYFVGLKSIGQLYIISGKDSKELGKLISDLGKFNGIFTQEEIYEFVQRRSDWVRVRKDVEKVMYGLGIRDCCIM", "function": "Involved in recycling plasma membrane proteins internalized by endocytosis. Required for recycling of the v-SNARE SNC1.", "AFDB_id": "AF-P39531-F1-model_v4" }, { "swissprot_id": "G3MZC5", "sequence": "MGPLGRETWAQRLGTFRASPSAFMAGPEGEDLGRDLLSDLRSEKLSEPMKVALLALSLEYPDQLWPDAPAAEAAATSLLDTLVLLPPRPSALRRPLLLAATTALAAGGALNPASGASGRLLPLLLGLASGRDLGRSFCPASEQRPLQATAWECLRELESCRPGLLGGCLGLLRALLGREGPAQPLSLLLALALRNALVIQARAGAGLQGLLTAGESSMEGGPWNWMLAEEGEVHLQPQAPSWPAAEEDECGLAALELSPEEARELRATVAQLLDASYLLTPVAQAQLLWLLGWALRGLRGQPPVLFKPQLVRLLGTAQLTLLHAMLALKAAFGEALFTAQDEALLLRRLTLAAQHPALPLPTHLFYLHCLLNFPENWPLGPTGEEAAPLLLGSQLCRGLLPSLLHEPMALLARLHLLCLLCVEDEEKEGKGQDRSPRHYLEELLAGLRQRAALDGGPRALATLCFQASYLVAHCLAGQPVVLIPLTQGLAQLYRARPALAPHFVDLLDHVGPELQEPLRVALRQEVASRPGREEALRWHLQMLASVADGDAQSATLSFLRAAAAHCTDWGLQQALLRVCRALLRAGVGGGLADLLQELARQLEDPDGQDHARLYYILLAHLAGPKLGVALGPSLAAPALASSLVAENQGFAAALMVQEAPAPIRLSVGPRRAEGAVPVLRLQVEVLEPVYSLELRFRVEGQLYAPLGAVHVPCLCPGRPTRPLLLPLQPRRPAPARLAVRALYSTPSGLTCHAHLPPLLVAFADLFLPFPQPPEGAQLDFFEELWDSCLPKGTESRLWCPLGPEGLEALVSRHLEPFVVVAQPPVSYLVAIRLPPDSRLLLRLEAAQADGVPVALRTDDWAVLPLAGDYLRGLSAAG", "function": "As part of AP-5, a probable fifth adaptor protein complex, it may be involved in endosomal transport.", "AFDB_id": "AF-G3MZC5-F1-model_v4" }, { "swissprot_id": "P40164", "sequence": "MSLPGTPTTSPTPMDEDTEQAVSVNTEPKRVKVYILENNEWKDTGTGFCIGEVDEGKFAYLVVSDEDSPTETLLKSKLEGNIEYQRQEETLIVWKDLGGKDIALSFEESMGCDTLCEFIVHVQRNIESNISLVTVKSSDNGLGSVHDIITGPVTLPSNDQQQNSQTLLEALKILNENTSFDFLKNETIEFILQSNYIDTLISHFHKAEEEKIPKDLFLLSNIIKTLILYNKRDILESMVEDDRIMGIVGILEYDTEYPTSKANHRKYLGSKGPNFKEVIPLENEDLKIIMKKCFRLQFLKDVVLVRFLDDHNFNLISEIVMDLETCIIDFLQVGTFLDRLIELYDTKTLPESSSEKEKFVQKRKDGIRLLQQCVQMSINLDAVDRSKFYKTLVRKGLFKVLDYAFHMETDSNVRILATDTIITIIEHDILLIHNVQNEDSFKRQHKSAPDDKSSHRKYPQDYSSSTDSKLLLILSTILLSDRSPGLREQVVQALNTLLHPEGCVGNGEGSYDLMGRSNYEAKNTSEDFPSFSYGLNSDSINLNNYHYSSDEMNNLEPESESEFQVMEYFANFYNKIAPILFGPLIKKDITTEMAEIDGQIEKVTKDDLLLIHLVKLVSFVCTEHDRVLSRRFILENGILDSVSKLIGGNHMMQLRLTAVRCIKNLMCLDDKYYHRYMISKNLYAPVFKLFQENIDKNNLANSCIQDFFRIIITECRAYQSDGHNRKEKTNGSYDGNGNDVKTNVNNNRTNFTILNKYLVQTYGDVLRKATDIPFIQDMLETGEENQPDHSSFENSIEGGNDISVNMSTDGFASNHLEDIDIKNVKRLHSEIEHFENDPHYSGDQLAFKKSVDQMNAST", "function": "Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.", "AFDB_id": "AF-P40164-F1-model_v4" }, { "swissprot_id": "P38334", "sequence": "MPQYFAIIGKKDNPVYEIEFTNAENPQGFPQDLKELNPFILHASLDIVEDLQWQINPTSQLNGNGGNGSNGGGGFLRSRAVNNTDNCYLGKVDHFYGLAITAYISYSGMKFVMIHGNSANSSVVIDDNNMRSFYQEVHELYVKTLMNPFYKITDPIRSPAFDSRVRTLARKHLSK", "function": "Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.", "AFDB_id": "AF-P38334-F1-model_v4" }, { "swissprot_id": "P41846", "sequence": "MSRGQIIHSGHFMCSNPHDDLVQDEDEEDVEVDVVEDDDKSMEASSSVHHKNKALDEKPVTFYKFGVGKTQSIAIDVSLNKLNKCIKVAYNKMTTPKWKDFKGLRLHWKQRVRLNNVIWRAYYIEFRKKQPEKPKKPFCYFAVPDDDTTHQKIEGSIVEGMYWKRKMEGVCAQYKRWRIRSKHNLVTDKGGMVATCSSTSVSSMTGELKRKRKHTVPKETIESKLRSYEPPVKLQRSQTPKHTISDEFAWDFDDLDNVFTDDFLNSLSEPYMFPDPRDVYSGNNADIMQPGLLPLQPTIEDIMMSLGDDMPDSPPFHNDRDTMRTPTNDQPSISAQQIPQMRRSASSSASLHQMQVAQAQAQSISQISQPSQQLQHQIQIQQPVAARPHEFMASSIMMDYRLMPTRQSSAITSQMLMLSQSASTLSSQPQYATSTHYSTNNSFLPIRNTMTNQHHLGHTSQHSPWNKQQQSNFLVSLPHQSHVERILNNQPPLVPPPSRSNLLPTQNDPYLPQFLQSTQPTPQPQSHDPMMAPSRSWWLDSPLTASVQSPLSVATPLPLANQTGPQTPLGQLIGSADNGFLFGGNNTPGGFKMSGTTSGVPTLSQRLEQPPISRTSTIFGNVENKPERIFTSLTSQNTPTPSPLDISSLSRLRTSSLNESWKMSHIVEGSPTYQAFAASVTTKPSILESPSTSGDISGPASVPVQASQHPPKIITPPSASSKRKEQEAAMAPLVNRQQSCDVNLLNGKMAVKVEEKSGRHYLPTTPTELKEVTKEEPLLMSAPSSVKSMRRQAPDSTLHPEERKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGVKPTNAVVLAKSADHIRRLQAEKWDKTQKIDEAKAKIEKLNQKITSLQSNLPQSSAPSSSSQVDSKTSLETFFDRYVKEGAKKNWRFWVMSQMLKPICVTQTNSFASSVAGDSSSRNEVAASCSDWLNKNWKATELRPLASTLLVSLATNSSILAEPDTLPDYVMQQLKNPF", "function": "Transcription factor that binds to the E box motif 5'-CACGTG-3', probably in a heterodimeric complex with mxl-2. Involved in modulating longevity in response to TOR signaling, dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and the insulin-like signaling pathway. Plays a role in autophagy. Involved in regulating migration of the ray 1 precursor cells in the male tail, acting in concert with Wnt and semaphorin signaling pathways. Regulates transcription of genes encoding extracellular matrix (ECM) components which may contribute to the substratum required for migration of the neighboring ray 1 precursor cells. Involved in repressing infection by the microsporidian pathogen N.parisii, probably acting independently of its canonical partner, mxl-2.", "AFDB_id": "AF-P41846-F1-model_v4" }, { "swissprot_id": "Q44407", "sequence": "MFESVYNLPEQIQKAYEIGKNISVNVKAEDIDKVVITGLGGSAIGGNLLRVFVLDKCKIPVIVNRDYVLPAYVDSKTLVIASSYSGNTEETLSAYQDAKAKGAKIIAITTGGKLKEFAEKDGFDVITIPSGLQPRAALGYSFIPLLMLFVKLGLIEPVDDQIEETVKVLSDLRERYKPEVPEEKNLAKRLTLKLWNKLPIIYGISGTTEVIAERWKGQICENSKSPAYFNVFSELNHNEIVGTESPKHILGLFEIVMLHDTEDHKRNAIRMDITKDLIKGVVSGVNDIYSIGNSRLARMFSLIYLGDYVSLYLATLYQNDPTPVKKIDILKNKLAEIKD", "function": "Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.", "AFDB_id": "AF-Q44407-F1-model_v4" }, { "swissprot_id": "Q26263", "sequence": "MDYKNDINSDDDFDCSNGYSDSYGSNGRMSNPNGLSKAELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGGLQLIPSRLPSGEFALIMPNTGSAAPPPGPFAWPGSAAGVAAGTASAALASIANPTHLNDYTQSFRMSAFSKPVNTSVPANLPENLIHTLPGQTQLPVKNSTSPPLSPISSISSHCEESRAASPTVDVMSKHSFAGVFSTPPPTSAETSFNTSGSLNLSAGSHDSSGCSRPLAHLQQQQVSSTSGIAKRDREAEAESSDCSLDEPSSKKFLAGAIEKSSSAWRPW", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription. In the larval brain, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma-HLH. As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch. In the developing larval and pupal brain, required for mushroom body differentiation. Involved in sex determination and SXL transcription repression when in complex with the corepressor protein Groucho.", "AFDB_id": "AF-Q26263-F1-model_v4" }, { "swissprot_id": "G2TRS2", "sequence": "MSNQGKDSFKAYSYFCPCGQLFLTIHVSLTRLPQRQLDKRHVVDEKLNHIAHFSTGNKYYITRSDGGYEQRIQLLCRRCTLECAYALEAAPGYIYVDPTLVNEKPVTVSVSNLKE", "function": "May stimulate membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment.", "AFDB_id": "AF-G2TRS2-F1-model_v4" }, { "swissprot_id": "P82165", "sequence": "GYLSLPADTPEVAAAKVAHFAAYNAAAARSAGVVAVAPSYGYAAYGPANIVIGADGVPLDTPEVAARKAADAVAHARAAAGLPAVGPVPAAVVPAVVGSVPADTPEVAAAKVAHAAAHVEANVRNAAEAVGIHGLYGVVPSVYSYGVVPGAYSVHYDGTLLTPDGVPLDTPAVAAGKVANAVAHIKAKSGLIV", "function": "Component of the cuticle of migratory locust which contains more than 100 different structural proteins.", "AFDB_id": "AF-P82165-F1-model_v4" }, { "swissprot_id": "Q754X1", "sequence": "MNQWQLSYQSPVELTEHLRKSYWAYDAKEKSATKMAFDQDVNLIWVGDTYGRVSSYDPSYSLYTRHTAHIGAEPVVELLSHKQGVLSLGGESLNFANRRSVTKLHVTSADIAQLCDMRAMCYGSNSQNTVYCGGTNLASGLVAVDLVKGRLSNTVQYSSKVKLMQSSNRLMAVARQNGMLDLLDPNSNTVVKTFSGHSCMVSSMDFRDHTLVTAGKSKRFNMMYPDQFVNVYDLRIMKQLPPISFSKNTEYMGNGACYMVGADFVQLHPILPTVVVIGSVTGAFDFVDLSNPTVRTQYCHPCQSVTQLQLSPSGDYIAFIEHDNNINMWSRSNGMTGFTSTATTILEYPDYPDDGILAGATSIDDYSYPLSSVGLPYYNEKLLSAWHQTVFRSDGTIPMKVPLPPKSSAASSSHTALSTSSDSRPNTARSGNPSSGGQKYRLLPYDRHKYGHRNVAVPYRSLRERKKKLLITDEDGKDKQELMNYKPSNDREVPPAFTKLQMVYGRFGVQDFDFKAFNKTRYSGLETDIDNVYTNAVLQMYRFVPEVYNFLVSCLKMENFSDNSLLTELGSLYDMMVRANGEICRSSNFQEALASIPKSYLLGLITDSIDNALEPNTTVSGTSISDSDASGSSMTAKLESMVLGDDKTTISCHDNNDNSLTTPQKFNTFLLNRLLFEELQMKINTTQSIVLEELLGIDVQVTTRSISPCANFTRRSDIIPVLTVTSPISNNIKYVNKKLNNQTILPYIESSMSRLKHTKAMCEKCFKCETVESEKTVRNLPPLLSLNISLTSDEWATAKTVRGWLTKEFYATISKDRPILKLQPTDLKTTNAIFKYELNGYVARICDYITEPHLVAYSKIFDPTTRTYKWYMFNDFLVQEVDEEEALNISYWWKTPEIAIYSDAEELTKPFVPASFYTINYSILYRDHFANGMRESIKKEYRLLTAEEAPKPGSLVALDAEFVALSEDQVEISCKGTKTLIKPAKTALARVSVLRGEGDLAGVPFIDDYIVNTKHIEDYLTKYSGIEPGDLDPDTSSKPLVTRRVVLRKIWLLLQLGCIFVGHGLYNDFRNINIHVPKEQTRDTALYYLQGRRYLSLRYLAYALLDKDIQKGNHDSIEDAYTALVLYRKYLDLREKGIFETVLNRIYEEGRASNYRVPGDLQ", "function": "Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.", "AFDB_id": "AF-Q754X1-F1-model_v4" }, { "swissprot_id": "A0A172M477", "sequence": "MRLYILVLAAIAVTLVFASSGPAITYHEVGTRALRQASITDEKSDDSLNAQAPPLSKSEKRLSRSFRTTSRRLPYTNYYHPQYYHPQNYHPHYNYPQYHSSPHVYVHQESKKSWFVRMILEAGIFWAVFHCLSAAFC", "function": "Effector that partially suppresses the tobacco programmed cell death induced by cell death-inducing proteins.", "AFDB_id": "AF-A0A172M477-F1-model_v4" }, { "swissprot_id": "Q68FK4", "sequence": "MACVLEPPLRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLSMGTENNVKSLLDCNIIPALLQGLLSSDLQFIEACLRCLRTVFTSPVTPVELLYTDASVIPHLMLLLSRSIYAQEYICQIYAHCCKGPDHQTILFNHGVVQNIAHLLTSVSYKVRMQALKCFSVLAFDNPQVSMTLANVLVDGELLPQIFAKMLQRDKPIEMQLTAAKCLTYMCRAGSIRTDDNCIVLKTLPCLVRMCSKERLLEVRVEGAETLAYLIEPDVELQRIASITDHLISMLADYFKYPSSVSAITDIKRHQETGQPCIDPEEAEPRGTRDESQCTALSISHPVSQIQHDCLLTSEELDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIEAEHMMDRIVNGLSETSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDDILVVASSTLCNLLLEFSPSKEPILESGAVELLCSLTLSENPALRVNGIWALMNMAFQADQKIKSDILRGLSTEQLFQLLSDSDVNVLMKTLGLLRNLLSTRPHIDQIMSTHGKQIMQAVTFILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYVGHSNLKLQLAAMFCIANLTWNEEEGSQERQDKLREIGIVDILHKLSQSTDPNLCDKAKTALQQYFA", "function": "Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q68FK4-F1-model_v4" }, { "swissprot_id": "D0CCT2", "sequence": "MYKLMKNIQTTALNRTTLMFPLALVLFEFAVYIGNDLIQPAMLAITEDFGVSATWAPSSMSFYLLGGASVAWLLGPLSDRLGRKKVLLSGVLFFALCCFLILLTRQIEHFLTLRFLQGIGLSVISAVGYAAIQENFAERDAIKVMALMANISLLAPLLGPVLGAFLIDYVSWHWGFVAIALLALLSWVGLKKQMPSHKVSVTKQPFSYLFDDFKKVFSNRQFLGLTLALPLVGMPLMLWIALSPIILVDELKLTSVQYGLAQFPVFLGLIVGNIVLIKIIDRLALGKTVLIGLPIMLTGTLILILGVVWQAYLIPCLLIGMTLICFGEGISFSVLYRFALMSSEVSKGTVAAAVSMLLMTSFFAMIELVRYLYTQFHLWAFVLSAFAFIALWFTQPRLALKREMQERVAQDLH", "function": "Efflux pump that mediates resistance to chloramphenicol.", "AFDB_id": "AF-D0CCT2-F1-model_v4" }, { "swissprot_id": "Q09884", "sequence": "MDISSFLLPQLLRKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLIKQKLEEQILIQESNLEHKKISVFLVNKVPLVFQQAEYIRSQLPAKVGMFYGELSIEMSEQLLTNIILKYNVIVITADLFYLFLARGFLSINDLNLIIFDECHHAIGNDAYARIMNDFYHRAKAVLSKKHFTLPRIFGMTASPFTGKKGNLYHRLYQWEQLFDSKAHVVSENELADYFCLPEESYVMYSNKLVVPPSDSIIKKCEETLQGCKLISRAVKTALAETIDMGLWFGEQVWLYLVDFVETKRLKKKALGKQLSDDEELAIDRLKIFVEDWKNNKYSDNGPRIPVFDSTDVTDKVFKLLELLKATYRKSDSVRTVIFVERKATAFTLSLFMKTLNLPNIRAHSFIGHGPSDQGEFSMTFRRQKDTLHKFKTGKYNVLIATAVAEEGIDVPSCNLVIRFNICRTVTQYVQSRGRARAMASKFLIFLNTEELLIHERILHEEKNLKFALSELSNSNIFDSLVCEERERVTDDIVYEVGETGALLTGLYAVSLLYNFCNTLSRDVYTRYYPTFTAQPCLSGWYCFEVELPKACKVPAAQGSPAKSIRKAKQNAAFIMCLDLIRMGLIDKHLKPLDFRRKIADLETLEEDELKDEGYIETYERYVPKSWMKVPEDITRCFVSLLYTDANEGDNHIFHPLVFVQAHSFPKIDSFILNSTVGPRVKIVLETIEDSFKIDSHLLELLKKSTRYLLQFGLSTSLEQQIPTPYWLAPLNLSCTDYRFLENLIDVDTIQNFFKLPEPVQNVTDLQSDTVLLVNPQSIYEQYAFEGFVNSEFMIPAKKKDKAPSALCKKLPLRLNYSLWGNRAKSIPKSQQVRSFYINDLYILPVSRHLKNSALLIPSILYHIENLLVASSFIEHFRLDCKIDTACQALTSAESQLNFDYDRLEFYGDCFLKLGASITVFLKFPDTQEYQLHFNRKKIISNCNLYKVAIDCELPKYALSTPLEIRHWCPYGFQKSTSDKCRYAVLQKLSVKRIADMVEASIGACLLDSGLDSALKICKSLSVGLLDISNWDEWNNYFDLNTYADSLRNVQFPYSSYIEETIGYSFKNKKLLHLAFIHPSMMSQQGIYENYQQLEFLGDAVLDYIIVQYLYKKYPNATSGELTDYKSFYVCNKSLSYIGFVLNLHKYIQHESAAMCDAIFEYQELIEAFRETASENPWFWFEIDSPKFISDTLEAMICAIFLDSGFSLQSLQFVLPLFLNSLGDATHTKAKGDIEHKVYQLLKDQGCEDFGTKCVIEEVKSSHKTLLNTELHLTKYYGFSFFRHGNIVAYGKSRKVANAKYIMKQRLLKLLEDKSNLLLYSCNCKFSKKKPSDEQIKGDGKVKSLT", "function": "Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Digests double-stranded RNA (dsRNA) producing 21 to 23 bp dsRNAs, so-called interfering RNAs (siRNA). Required for both post-transcriptional and transcriptional gene silencing. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H3 'Lys-10' methylation necessary for centromere function. Required for recruitment of swi6 and cohesin to an ectopic dg repeat.", "AFDB_id": "AF-Q09884-F1-model_v4" }, { "swissprot_id": "Q8GMH2", "sequence": "MSAQLKILAINGSERDGNTADVLRHAARVAENRGVDFEAVDLRSIRMERCGPCGDCNDRPVACTLADGVPEVVAKMVAADGIIFAAPVHGFGTASLMQTFIERAGVGYLRFDRPLSNKVAGIISVARRYSAGEVWAQLTVNALLNRMILVGSGFPATVHALHRGDALKDEEGLTNVSRLVERMTDMIELLDEHRRLTGRSDVLASNEVNERVGLALNELQAQP", "function": "Converts 2-amino-4-deoxychorismate (ADIC) to 3-O-enolpyruvoylanthranilic acid (OPA). Involved in the biosynthesis of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.", "AFDB_id": "AF-Q8GMH2-F1-model_v4" }, { "swissprot_id": "P43255", "sequence": "MDLSPVKEALAAKSFDKIADICDTLMLQVASEGIEYHDDWPYAIHLLGYFYVDDCDSARFLWKRIPTAIKERKPEVVAAWGIGQKLWTHDYAGVYEAIRGYDWSQEAKDMVAAFSDLYTKRMFQLLLSAYSTITIHDLALFLGMTEDDATTYVVENGWTVDAASQMASVKKQAVKREQKVDSSKLQRLTEYVFHLEH", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.", "AFDB_id": "AF-P43255-F1-model_v4" }, { "swissprot_id": "O04348", "sequence": "MAIRITFTYSTHVARNLVGTRVGPGGYCFESLVRPRFFSHKRDFDRSPRNRPASMYGSIARELIGEGSQSPLVMGLISILKSTTGHESSTMNVLGVSSFKASSIIPFLQGSKWIKNPPVIDDVDKGGTVCDDDDDKESRNGGSGWVNKLLSVCSEDAKAAFTAVTVSILFRSALAEPKSIPSTSMYPTLDKGDRVMAEKVSYFFRKPEVSDIVIFKAPPILLEYPEYGYSSNDVFIKRIVASEGDWVEVRDGKLFVNDIVQEEDFVLEPMSYEMEPMFVPKGYVFVLGDNRNKSFDSHNWGPLPIENIVGRSVFRYWPPSKVSDTIYHDQAITRGPVAVS", "function": "Cleaves the thylakoid-transfer domain from a chloroplast protein.", "AFDB_id": "AF-O04348-F1-model_v4" }, { "swissprot_id": "P77416", "sequence": "MENLALTTLLLPFIGALVVSFSPQRRAAEWGVLFAALTTLCMLSLISAFYQADKVAVTLTLVNVGDVALFGLVIDRVSTLILFVVVFLGLLVTIYSTGYLTDKNREHPHNGTNRYYAFLLVFIGAMAGLVLSSTLLGQLLFFEITGGCSWALISYYQSDKAQRSALKALLITHIGSLGLYLAAATLFLQTGTFALSAMSELHGDARYLVYGGILFAAWGKSAQLPMQAWLPDAMEAPTPISAYLHAASMVKVGVYIFARAIIDGGNIPHVIGGVGMVMALVTILYGFLMYLPQQDMKRLLAWSTITQLGWMFFGLSLSIFGSRLALEGSIAYIVNHAFAKSLFFLVAGALSYSCGTRLLPRLRGVLHTLPLPGVGFCVAALAITGVPPFNGFFSKFPLFAAGFALSVEYWILLPAMILLMIESVASFAWFIRWFGRVVPGKPSEAVADAAPLPGSMRLVLIVLIVMSLISSVIAATWLQ", "function": "Possible component of hydrogenase 4.", "AFDB_id": "AF-P77416-F1-model_v4" }, { "swissprot_id": "C6WX20", "sequence": "MEHAAFVHNEEQYIVHNPKEVTQIINDLIKHKSMIKVTFNHGADVYLTSIISIDAKTGAVYLDVGVDDEFNRRLLASNHVVFIKEDGVKIKWTSAHIAGVELKDGKAIKIALPKDMVRLQRRDFYRFATPVANPVVCKIPVPDVLNPAEETILELSLVDVSLGGIGTLVAAPLNPALVLGQAFNGCKIGFPDVGETNLTLKVKNITEIHVQDVMTKYRVGFEYVEPSRGNEGLINRYVYILERQAIALAHGAA", "function": "Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.", "AFDB_id": "AF-C6WX20-F1-model_v4" }, { "swissprot_id": "P39595", "sequence": "MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDGDMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLEELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVTSWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYSWWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTVLFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRSLLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGMRIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYSTIPQMLILLFLLIALVSEAAKHFTNGKELTK", "function": "Uptake of Fe(2+) ions across the membrane.", "AFDB_id": "AF-P39595-F1-model_v4" }, { "swissprot_id": "O44342", "sequence": "MMHILVTLLLVAIHSIPTTWAVTCTGCVDLDELSFEKTVERFPYSVVKFDIAYPYGEKHEAFTAFSKSAHKATKDLLIATVGVKDYGELENKALGDRYKVDDKNFPSIFLFKGNADEYVQLPSHVDVTLDNLKAFVSANTPLYIGRDGCIKEFNEVLKNYANIPDAEQLKLIEKLQAKQEQLTDPEQQQNARAYLIYMRKIHEVGYDFLEEETKRLLRLKAGKVTEAKKEELLRKLNILEVFRVHKVTKTAPEKEEL", "function": "Probable chaperone protein involved in dorsoventral axis patterning in early embryos. Probably acts by folding and targeting pipe (pip) into the Golgi.", "AFDB_id": "AF-O44342-F1-model_v4" }, { "swissprot_id": "Q5FC18", "sequence": "MQPASLAGISCTIFENLLKDYTHELTQTVHKNAKLSLQKCPACNKHCRQYCTKPGYDIYGNSVQTPSNVPYYSCLMCKREIAASRYAAHLEKCKGRSLSNATSYSTLFEDDNADEED", "function": "Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.", "AFDB_id": "AF-Q5FC18-F1-model_v4" }, { "swissprot_id": "P43127", "sequence": "MTIQCKVKSIQPLACNTYQILLHPESPVPFKAGQYLMVVMGEKDKRPFSIASSPCRHEGELELHIGAAEHNAYALEVVEAMQAALETDGHIEIDAPHGDAWVQEESERPLLLIAGGTGFSYVRSILDHCVAQNKTNPIYLYWGARDNCQLYAKEELVEIADKFANVHFVPVVEEAPADWQGKVGNVLQAVSEDFESLENYDIYIAGRFEMAGAAREQFTQNKKAKSERMFADAYAFI", "function": "Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Preferably uses riboflavin as an electron acceptor when NADPH is used as an electron donor.", "AFDB_id": "AF-P43127-F1-model_v4" }, { "swissprot_id": "Q9VH89", "sequence": "MVRTRPVPCVPSPDVNTATRRNPGRPKKQSIGADLSTTISKPGRPKKLSIGADLTTIRKPGRPKKLGADLTTIIRKPGRPTKLSNKQSLTALNEPECRIRKCVVKIRRIKVKNGVVSEISRNDAPDVDASTFEPARNSTMYIPSKVQKSTQPQNIKENVAGPETSPCQQRIRSKSPSGPAAEISPKKPPRFFHRDQPLTRTRSSVTRNVFDFLSQSQIEDDSDREDPAADIIQRLVKDGKACVMVRSRKIGKPRAKRTAKKVRPVGNRRKVSTKDNEPEPVKVVPKSIEPRLQKPSRSLSTIFEPEEDYSNDSEHGYVQPIEVPVQVHVEPSTSKQAHEGAYSNLARSVMLNQTQAQNPLPSTDRRRELINMARQLVSTPLNRRAPPVTDVSATTTALSPIAHQSPNAVRTAGGKSPWRVSDDSPLPNTFMFGFNNSQMPSYSSDHVQRRHVYVPDSPVEHAENIPHEESICPPLHEQNHDSNANDSNEENRPPPTISKSMSINDQESEENAENFVHLPNPRRTLQKRTPFKDINILEVVTLPSWKKNVTATVSKEITPTRVAPRPMATSSPAQRSQTRSNLFGFDDDFACEDIPRKSTTPSKGIAPTSMSLNREVTPALANRNQTEVNTFGCNEILPCENIPKEKETNTEERTSSSQNLFGFDEFITESQDSPANFTGLSQNVNLHDKLHRLAELRPRDGELPQVSYTSIRSDCLGESHSKQTDIRYMLCSTMIAPPRPAKRKPAAPTARESMGLFRVDQDEPEQSFADKQPRRTYVKERPQRKRKKRVQILYIESESEDEDEQDSHDKSLDSPEKKRHHVKRPRRDIEHEAKLEQFVTSFNKQCEEVEKFPVIIE", "function": "Regulator of sister chromatid cohesion in mitosis. Probably involved in development of the central nervous system.", "AFDB_id": "AF-Q9VH89-F1-model_v4" }, { "swissprot_id": "Q9TLX6", "sequence": "MYKRDTIAAIATCPNGGGVSILRLSGSKSIDVVKTVSLVSSNQCWHSHCILYGWIKDNEDQSFVDEVLILLMMAPRSYTAENVVEIHCHASIVLANEILRILVKQGVRLAKPGEFTMRAFLNGRIGLSQVESVLKVIHSKTIASAKLAANTLRRGGSERIRRLKHTLSLLLADLEFHIDFSDEFIDVDSIEDELRSTIQSSLLDIKDLISSYNKVSKLNEGTKVCIIGKPNVGKSSLLNAIAKRECSIVTNFPGTTRDIVSFETMLGNTLVRLYDTAGIRQSVDEIEKIGISKTELFVDECQIVFFVLDAIQGLSSEDSVIFNKLNLMNKNFVILINKIDKKVQRKIDEIYETLKCSNRRIIEVSAIKNIGLEKLNNCILDLSSKEDFDLPVHFSVNCKYLEILNNIYLILDELYTGSLNKSVTSYDFIAVELRRVLQGLNQITGDEVVENNVLDAIFSKFCVGK", "function": "Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.", "AFDB_id": "AF-Q9TLX6-F1-model_v4" }, { "swissprot_id": "P71014", "sequence": "MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRTQSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNALRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFYAEASIDVAKRSTPPTQPCGCN", "function": "Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression. Required for complex colony architecture. May function synergistically with exopolysaccharides and TasA amyloid fibers to facilitate the assembly of the biofilm matrix.", "AFDB_id": "AF-P71014-F1-model_v4" }, { "swissprot_id": "K4PW38", "sequence": "MVGSGAAGGGGGGGGGGDHARSKEAAGMMALHEALRNVCLNSDWTYSVFWTIRPRPRCRGGNGCKVGDDNGSLMLMWEDGFCRPRVAECLEDIDGEDPVRKAFSKMSIQLYNYGEGLMGKVASDKCHKWVFKEPSECEPNIANYWQSSFDALPPEWTDQFASGIQTIAVIQAGHGLLQLGSCKIIPEDLHFVLRMRHMFESLGYQSGFFLSQLFSSSRGTSPSPSSFPLKQQQPPPPQLFNWPGHAPPQLPPGASPLFPPGPAAFHPSSRPMPPFPGGGKDESHLFHLPPAAAAKQPQHMDEHHHHQQQPMAAPQQHGGEAPEGDLKWPNGLSFFTALTGRTEDAKFLFGGGGGGGADDGSKTAAAAQDAGHGGAENVEEYLSLESHSNKARRMESAQSTKFKRSFTLPARMSSSTTSTSPSVSASTAPAPPQQQQGMEYRGPHEGGVYSDLMETFLE", "function": "Involved in the repression of jasmonate (JA)-induced genes. Forms a ternary complex with TIFY11A/JAZ9 and BHLH094 to negatively regulate JA-responsive genes. Involved in transcriptional regulation in the root tip. Plays a regulatory role in root cell elongation. Regulates root cell elongation during salt stress.", "AFDB_id": "AF-K4PW38-F1-model_v4" }, { "swissprot_id": "Q05FY9", "sequence": "MNTIFSRITPLGNGTLCVIRISGKNVKFLIQKIVKKNIKEKIATFSKLFLDKECVDYAMIIFFKKPNTFTGEDIIEFHIHNNETIVKKIINYLLLNKARFAKAGEFLERRYLNGKISLIECELINNKILYDNENMFQLTKNSEKKIFLCIIKNLKFKINSLIICIEIANFNFSFFFFNDFLFIKYTFKKLLKLLKILIDKITVINYLKKNFTIMILGRRNVGKSTLFNKICAQYDSIVTNIPGTTKNIISKKIKILSKKIKMMDTAGLKIRTKNLIEKIGIIKNINKIYQGNLILYMIDKFNIKNIFFNIPIDFIDKIKLNELIILVNKSDILGKEEGVFKIKNILIILISSKNGTFIKNLKCFINKIVDNKDFSKNNYSDVKILFNKFSFFYKEFSCNYDLVLSKLIDFQKNIFKLTGNFTNKKIINSCFRNFCIGK", "function": "Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.", "AFDB_id": "AF-Q05FY9-F1-model_v4" }, { "swissprot_id": "Q8SWI4", "sequence": "MVRRSLYFLAVMGVVRSSSGLYIPSVVLQELGIASSQGCLMIAETNNGNFGIVSSGLENPVYITESPQGHREVSWQPVRGEDRAVPIYAPSAEEVRESISSVRGSEPGQYIAPQPTGFVPASTPVFGTIESASTAGAAVPVEGVFVASTENPASTGSSSTSTCPPKGTAGTTDNKGKAGGAAADDKSKSSSSSSSKKKKKGAKSLVALGAVATTALFSIVM", "function": "Spore wall component.", "AFDB_id": "AF-Q8SWI4-F1-model_v4" }, { "swissprot_id": "P0AF22", "sequence": "MTPGGQAQIGNVDLVKQLNSAAVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIVTETRNFHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILLQHLLEN", "function": "Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon.", "AFDB_id": "AF-P0AF22-F1-model_v4" }, { "swissprot_id": "Q23229", "sequence": "MQVEANSERRVKILGIDRSENSPVLTYMETEDDPNFRNSKLAAAPHTVHMMDSGFLAINRQCLVKGKAILAREPKSSNEHMIDDLPKHAHDQHTLSILRDFIDQLKLHNVYEINFYDPLDSSGKLAVIPMLIALWKCMLASETDICDQEVLKSIMNSVIAKFELQIPCKNAVIDATLSGSREEVHIIAEDGSLENSNGTTEHFNKKHDLVFVKTDLHPEDFTPQMFPSQAKAKLLRDAFNNEEDEDTFPDILVPAYMTAHSKNRVRQEDYTCLEVEFDSQVALEKLMNEHEQVEGFEVQQGGILVALKKDSFFDDELIEKIAIAIATESRQSVSSVSFDLLKLGPGASLVTLANSRRFEPECRVVLQIEVKPVSPGETSSEGISDEHHYEEYDEDDIMEEEEAPSARQDDTYDEDEE", "function": "Sex-determining factor that is required for sexual differentiation and X chromosome dosage compensation to promote male development. High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear.", "AFDB_id": "AF-Q23229-F1-model_v4" }, { "swissprot_id": "Q54V07", "sequence": "MKVIYIYLLLLLVCKFLFVKSSCSLKVGKIECTKELETFLLYNETVVNVKMDTNGVKYYFNALEFPYKNLLCDLNIDIKFTPEIPSFPNIPTTGGDFGFTFNFPCDYRRRVKRIEIERTILSLSFDTSKNQFVTYLNPGCGPFNISSSGIQILSTTYETGAIPNVPILDDDKGILTIQGSNLYNTSIKIYSNNILKDTNPSGALDASHSSVTFSAEEFLTPNNWTIEVSICGSFYKSYSFPYFPKLDKMEGVLNDNGGNMVFTGKHLRPKHNVTGTFGNKTIECLTSNSSKSITCTIPSRKNYGFLGYDIPVTITIDGEYKSNTIKISYDLPLIQSVSQRGNSQIFDVTGVYFSGVKNMTVITGKNMKTDIIQKKTATLEEPGFFIESNYTIFIFLPNNTQPGFMNLVVGDGGSETFTSPRYNFKITPTITAGQTFNSTTSGNDLEIKGIFMRTVDSDGRDVPLTVNSGSGGLVCNPLKDGDGLLFTCVLGPGFGSSHTMNVYYNLIPIGSFTVSYNPPYLGTSEQEKDGTIKMNGKDLGESVKDSIMTVVYSDGNTVNGTVIKSSHTSLIFRYPIGNRNTASYIFQLGDQKSNKAGPFTLKPIIENTDPAVPCGGGVVTINGHYFFNYTKDTTTITIGKVPCNISSISETTIECVIVPNLRSLSPYYTSGTKPLVISSSNPGTEKVYQLTPAGLNYKFAPPTITNTSAIDQTALITIYGTSFGDANLEILINDKPCTQPEINIHTYSSLTCNVTNYDEMKIYNYSNTKFNISISVDGQYFIADIFQFKYESGIIYSENKSTGFPNEMYLGFVVFVIFIALISFAAKNQIEKYFEERKSRKAFRSLDNLRLKLRQKHATEIAKHYTFGEQSAPKPDKSTFYDIRKKLSRLPLIRRCFKEHTD", "function": "tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development.", "AFDB_id": "AF-Q54V07-F1-model_v4" }, { "swissprot_id": "Q0P8J9", "sequence": "MKNNPYIIWLTGLAGSGKTTIGQALYEKLKLKYKNLIYLDGDELREILGHYAYDRQGRIDMALKRAKFAKFLNDQGMMVIVTTISMFNEIYDYNRKQLKNYYEIYIECDMHELIQRDQKGLYTKALNKEIDNVVGVDIEFDKPEADLVINNSCRNNLEEKVELIIKKLAL", "function": "Involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the ATP-dependent phosphorylation of cytidine diphosphoramidate (CDP-NH(2)) to form cytidine 3'-phosphate 5'-diphosphoramidate. Can also use other substrates such as the corresponding adenine and uridine diphosphoramidate derivatives or cytidine diphosphoramidate analogs, with lower efficiency.", "AFDB_id": "AF-Q0P8J9-F1-model_v4" }, { "swissprot_id": "Q5U430", "sequence": "MAAAAAAAAVGDPQPPQPEAPAQGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLNAERPLAGAAGGEEAAGGGGGGPGEAEEDALEWCKCLLAGGGGYEEFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRESGFCRRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADAPSEKDLNKVLQLLEPQISFLEDLTKMGGAMRSVLTQVLTNQQNYKDLTAGLGENACAKKSHEKYLIALKSSGLTYPEDKLVYGVQEPAAGTSTLAAQGFAGATGTLGQIDSSDEEDQDGSQGLGKRKRVKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFTKTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESCLIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAQRFLEDHGLLVTWMNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTRNVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSLLPDQEMLMKLMIHPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLLTMASQHHNMVLDVEHERSMLEGALTFLVILLSLRLHLGMSDDDILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFRAPIFEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFPGNPWPPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCMVLYLIELGLENSADDDSEEEVSMGGPERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPELKRDPLASTSSDALDSLQNSGTAQVFSLVAERRKKFQEIINRSNSEANQVVRPKIPSKWSAPGSSPQLTTAILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIEVLIQPEIPKYNHGDGITAVERILLKAAVQSRMNKRIIEEICRKVTPPVPPKKITAAEKKTLDKEERRQKARERQQKLLAEFASRQKSFMETAMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQASSVLGQCRDNAEPKKLPIAEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGGVYVQTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVENNLWQRPCNKSTQDLIKEVEELQGRPGAFPSETNLSKEMESVMKDIKNTTQKKYRDYSKTPGSPDNEFLFMYSVARTNLELELIHRGGSLCSGGPSTAGKRSCLNQLFHVLALHMRLYTIDSEYNPWKKLTQLVEDMNSQVGNEDQQPEVPILYHDVTSLLLIQILMMPQPLRKEHFTCIVKVLFTLLYTQALAALSVKGTEEDRSAWKHAGALRKDTCDAEKCYEVLLSFVISELSKGKLYYEEGAQECAMVSPIAWSPESMERYIQDFCLPFLRVSSLLQHHLFGEDLPSCQEEEEFSVLASCLGLLPTFYQTDHPFISASCLDWPVAAFDIITQWCFEITSFTERHAEQGKALLIQESRWKLPHLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQQSYCECVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICEERYRVLEQQWVSHTFDHINKRWGPHYNGL", "function": "E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May play a role in Shh signaling by mediating the ubiquitination of Kif7. May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A.", "AFDB_id": "AF-Q5U430-F1-model_v4" }, { "swissprot_id": "P38257", "sequence": "MSQIVDFVEDKDSRNDASIQIIDGPSNVEIIALSESMDQDECKRAHVSSAEMIPSSPQRKSVSNDVENVDLNKSIELSAPFFQDISISKLDDFSTTVNSIIDSSLRNENNAKGNAKKLLDDLISDEWSADLESSGKKHNKSQYNLRDIAEKWGVQSLKNPEPIAVDCEYKTQGIGKTNSDISDSPKSQIGAADILFDFPLSPVKHENPTEEKHNSIANENSSPDNSLKPAGKQNHGEDGTSMAKRVYNKGEDEQEHLPKGKKRTIALSRTLINSTKLPDTVELNLSKFLDSSDSITTDVLSTPAKGSNIVRTGSQPIFSNANCFQEAKRSKTLTAEDPKCTKNTAREVSQLENYIAYGQYYTREDSKNKIRHLLKENKNAFKRVNQIYRDNIKARSQMIIEFSPSLLQLFKKGDSDLQQQLAPAVVQSSYNDSMPLLRFLRKCDSIYDFSNDFYYPCDPKIVEENVLILYYDAQEFFEQYTSQKKELYRKIRFFSKNGKHVILILSDINKLKRAIFQLENEKYKARVEQRLSGTEEALRPRSKKSSQVGKLGIKKFDLEQRLRFIDREWHVKIHTVNSHMEFINSLPNLVSLIGKQRMDPAIRYMKYAHLNVKSAQDSTETLKKTFHQIGRMPEMKANNVVSLYPSFQSLLEDIEKGRLQSDNEGKYLMTEAVEKRLYKLFTCTDPNDTIE", "function": "Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions. Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures. May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover. In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved. Spore formation and viability are severely impaired in deletion strains.", "AFDB_id": "AF-P38257-F1-model_v4" }, { "swissprot_id": "P79051", "sequence": "MGTSCNKINSNSNKGKENMHFVLDDNGDSKGNASNQQVERDDKLDMETTRWNGKEFEEPLSTNKKLIIQSNNTSSQHSTPPLSISDTSTHTGSSTDNVEANPNTGFSSARKRSLRSSNLKKKFVPLSSPEESNESEFIDDDESDEVASIIDIKEDETFDSKVEIPEAAPSSSTESDEESIPLSYQSKRRRVSARASSSASSSSRTQAKSIPSHERTHYRLIRQHPELEHVWEKLEEEAPREVKQIEQPKELVLNLLPFQREGVYWLKRQEDSSFGGGILADEMGMGKTIQTIALLLSEPRGKPTLVVAPVVAIMQWKEEIDTHTNKALSTYLYYGQARDISGEELSSYDVVLTSYNVIESVYRKERSGFRRKNGVVKEKSLLHQMEFYRIILDEAHGIKSRTCNTARAVCGLRTTRKICLSGTPLQNRIGELFSLLRFLRADPFAYYYCLQCECKSLHWRFSDRSNCDECGHKPMSHTCYFNAEMLKPIQKFGYEGPGKLAFKKVHSLLKHIMLRRTKLERADDLGLPPRVVEVRKDLFNEEEEDVYQSLYMDSKRKFNTYLAEGVVLNNYANIFQLITRMRQMADHPDLVLASKRKTVDIENQENIVCKICDEVAQDAIESRCHHTFCRLCVTEYINAAGDGENVNCPSCFIPLSIDLSAPALEDFSEEKFKNASILNRIDMNSWRSSTKIEALVEELYLLRKKDRTLKSIVFSQFTSMLDLIHWRLRKAGFNCVKLDGGMTPKARAATIEAFSNDINITIFLVSLKAGGVALNLTEASQVFMMDPWWNGAVQWQAMDRIHRIGQKRPIKVITLCIENSIESKIIELQEKKAQMIHATIDQDEKALNQLSVEDMQFLFSN", "function": "Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation.", "AFDB_id": "AF-P79051-F1-model_v4" }, { "swissprot_id": "P18615", "sequence": "MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQRKSLYESFVSSSDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSASPPRSRSRDRSHERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRERDRDRERDRDRDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKENLVDGF", "function": "(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.", "AFDB_id": "AF-P18615-F1-model_v4" }, { "swissprot_id": "Q65Z91", "sequence": "MQFLAWFNMLLLLPCFSTTKTCFPGCHCEVESFGLFDSFSLTKVDCSGIGSHIVPVPIPLDTSYLDLSSNKLETINESMLTGPGYTTLVSLDLSYNNIAKISSTTFSRLRYLESLDLSHNSLEVLPEDCFSSSPLGDIDLSNNKLLDIALDVFASKGQGKPLNVDLSNNMLSKITRNHEKSIPNIQNLNLSGNRLTSVPNLQGIPLRYLNLDGNPLAKIEKGDFKGLKGLIHLSLSGLHDFRELSPYSFKELPALQVLDLSNNPNLRSLTAEVIFGLNSIQELNLSGTGVSSLPKTVLKYLPSLKSITLRKNIQCFKTIKEGQYHRQIGLTKLGLGAEELLWCKTPCPRPVCRCRDKPLQSAPQNLPTP", "function": "Shows weak bone morphogenetic protein antagonistic activity.", "AFDB_id": "AF-Q65Z91-F1-model_v4" }, { "swissprot_id": "B6JVP0", "sequence": "MTTTIVLASPNYAANESKFATSLAKFQANSTDASHQRDIHMIDRIAGNLASLTVNAYDRGLLFLDESTTLEEIKAILPKLFAAVHPGAALSVDGVFAKELADAFERESLLAGWMIESKGPFVLRRPAQVEAVPLKLSTKKSAGASVGVKLDFLFKKPEKQNTLSKNDVLKAAQEEEEGEDDLYDEDALVSDEETQLGKDVLAPPSTCSKPGKKKRCKNCTCGQREQDEAEAAAASAAAPKAVKLTDTMEIDFTELLKSKNAVSSCGSCYLGDAFRCSGCPYIGLPAFKPGEQVLISENRDKLSWMADDL", "function": "Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.", "AFDB_id": "AF-B6JVP0-F1-model_v4" }, { "swissprot_id": "G5EEN8", "sequence": "MARKTIDSIPEPIALPTEETVQKRIKLKMVDLDAEIAKLNVQSLDSSIQMIRDIDQMNVDAVQTTAALEDQDEQLDKIEANLSNVIDDLNVVSHNITAMEHYCGCGFFRILRAPFKYFRKRERDIIKEEVLEKMTSPKLRRKEESNMMMFTNSSKRRESTGDFMKRLTCDAIEDELERNLMQIDQGLESVKNLAVDMHVQLKLQEPKLNRIEELTETNDFVVEGVNDKVKKLLH", "function": "t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.", "AFDB_id": "AF-G5EEN8-F1-model_v4" }, { "swissprot_id": "Q57310", "sequence": "MRIFISTGEVSGDLQGSLLVGALRQQAEEQNLELELVGLGGEKMAAAGLTLLANTAAIGSVGLTESLRFIIPTWQIQQRVKRYLKTNPIDLLVLIDYMGPNLTIANYLRKTYPNLPILYYIAPQAWVWSPTKRETAQIMAVTDRLLAIFPGEAEFFQKQGLDVTWVGHPLLDRITKEAPSRGSAREKLGIDHNETVITLLPASRIQELRYLLPSICGAAQQLQSQLPNVKLLLPVSLKDYQPQIEQTLKEFNLTVQLLEGKETLTAIAAADLAITKSGTVNLEIALLNVPQVILYRVSPLTMAIARRIFKFNLPFVSPTNIVLNRGIMPELLQEQATASNIAQAGLELLLNGDRQAKIAQDYQELREALGEPGVCERAAQAVLEFANGQQKSRA", "function": "Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.", "AFDB_id": "AF-Q57310-F1-model_v4" }, { "swissprot_id": "Q826W3", "sequence": "MDDGRGAGGFGGGPAVRALDTEAVHAGRDDLARQGLHAAPIDLSTTYPSYDSRAEAARIDAFAADGAEPAGPPVYGRLGNPTVARFETALARLEGTDSAVAFASGMAALSAVLLVRNAMGLRHVVAVRPLYGCSDHLLTAGLLGSEVTWVDPAGVADALRPDTGLVMVESPANPTLAELDLRALAHACGSVPLLADNTFATPVLQRPAEHGARLVLHSATKYLGGHGDVMAGVVACDEEFARGLRQIRFATGGVLHPLAGYLLLRGLSTLPIRVRAASSNAAELARRLAADPRVARVHYPRIGGAMIAFEVYGDPHEVIAGVRLITPAVSLGSVDSLIQHPASISHRIVDAADRRGAGVSDRLLRLSVGLEDVEDLWADLDGALGTDRLPETAGAGREPSRTALRLPERAADR", "function": "Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia. Is probably involved in L-methionine catabolism. Is also able to catalyze the alpha,gamma-elimination of L-homocysteine, and, to a lesser extent, the alpha,beta-elimination of L-cysteine.", "AFDB_id": "AF-Q826W3-F1-model_v4" }, { "swissprot_id": "Q9MCI8", "sequence": "MSKKFTMTLLSSSLAGLLVMSGGVSAQNGTYSVLQDDSQKSGPVKYGSTYEVVKTVDNGNFRYEVKEKKNDKRTLFKFDSEGNVTVKGKGITHTLHDPALKDFARTAEGKKNEQNGNTPPHKLTDSAVRGVYNKVYGLEKTEITGFSVEDGENGKVSLGSDAKASGEFSVAVGNGARATEKASTAVGSWAAADGKQSTALGVGTYAYANASTALGSVAFVDNTATYGTAAGNRAKVDKDATEGTALGAKATVTNKNSVALGANSVTTRDNEVYIGYKTGTESDKTYGTRVLGGLSDGTRNSDAATVGQLNRKVGGVYDDVKARITVESEKQKKYTDQKTSEVNEKVEARTTVGVDSDGKLTRAEGATKTIAVNDGLVALSGRTDRIDYAVGAIDGRVTRNTQSIEKNSKAIAANTRTLQQHSARLDSQQRQINENHKEMKRAAAQSAALTGLFQPYSVGKFNATAAVGGYSDQQALAVGVGYRFNEQTAAKAGVAFSDGDASWNVGVNFEF", "function": "Binds (in a non-immune fashion) to the Fc portion of human IgA and IgG; binding occurs on the cell surface. Confers the ability to survive exposure to human serum exposure. Binds to the Fc portion of human IgG, IgA and to whole mouse antibodies also via Fc. Upon overexpression cells acquire an extra cell surface layer that forms a zipper-like contact between cells; cells autoagglutinate and form biofilm more readily, suggesting it may play a role in defense against a host.", "AFDB_id": "AF-Q9MCI8-F1-model_v4" }, { "swissprot_id": "A3MXT8", "sequence": "MKVRIRGIFATALTKLALDWGFSIVQPTGKIVERFDLPVDNSPPDVTVIDHESKSGVVVLGKCGAVEAFVERLREAVDPVVVKADLGVHDVFVGKVVGEGRVEGPGGIVLRVPPRFAPTVGSVGVFTVVRPPLGPVEGVAVPDIIVEGDYVELSTSPGVRFSRHIPEGERVRLRLLAETRLGWLGGLGVRFKSSARFAEDEAVVREAEALYRELVELAKGGEAGAVLRRGRCLALALFDKAAKERLDEVRRSVVPTARGHHALRAQGLGKCLDLLDYLGVEAYERAAEFLARGAVEIWHIKPWGEMVKMRGEAVGVFGDWLVVKRPLRPGGVLDGIGVKIERGFYALTCVPRRGNYVVHTYYTPEGRAVGTYINVNSEPEWGRRIIYIDLLVDVAYVGGEAKVLDLEEYRRYEDVFPARLRPPSGVLSPPVACGERGIIEAPPQSASS", "function": "Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.", "AFDB_id": "AF-A3MXT8-F1-model_v4" }, { "swissprot_id": "Q8TEE9", "sequence": "MTPLAPWDPKYEAKAGPRPVWGANCSSGASFSGRTLCHPSFWPLYEAASGRGLRPVAPATGHWNGQQAPPDAGFPVVCCEDVFLSDPLLPRGQRVPLYLSKAPQQMMGSLKLLPPPPIMSARVLPRPSPSRGPSTAWLSGPELIALTGLLQMSQGEPRPSSSAVGPPDHTSDPPSPCGSPSSSQGADLSLPQTPDTHCP", "function": "Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.", "AFDB_id": "AF-Q8TEE9-F1-model_v4" }, { "swissprot_id": "Q9W534", "sequence": "MSDETTISLEDGYPPLEALTTMVPPADATGFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAAAFIISLCIADLLFCALVLPFQGLRFVQGTWRHGQVLCRLIPFIQYGNIGVSLLCIAMITINRYVMITHHGLYARIYKRHWIAVMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSIMTDDHGHSSKTTLFITAFVIPCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGALPSGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSFVVCYLPITIVKVADKNVEHPSLHICSYILLYLSACINPIIYVIMNKQYRKAYKTVVFCQPARLLLPFGKTNGASSAAEKWKDTGLSNNHSRTIVSQMSGGTGAASGAGTATGTAAVAVMQTPPEVQQAQALEMVSRGPDLISKSNLPQPNVTPPPPSVLTATPNGSNSNSLTLRLPLKKNNHCYTNSGFNSSTPSPSSGLGIGISSSSIYRPGVGSLGSGSASIRRITMVGDDIILEEEELPPTPPATSAPTTPAPPPPSSPLHPLSTDSSTTTISGGAVVAGSSAPKPATPTPHIYMNVDSPKRNQYYMDRNTNAVAPESDSGPANTSATVSISGSKLTAKMKFPKD", "function": "Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in turn is necessary for the formation of septate junctions of sufficient length to achieve proper sealing of the nerve cord.", "AFDB_id": "AF-Q9W534-F1-model_v4" }, { "swissprot_id": "P36044", "sequence": "MLQRISSKLHRRFLSGLLRVKHYPLRRILLPLILLQIIIITFIWSNSPQRNGLGRDADYLLPNYNELDSDDDSWYSILTSSFKNDRKIQFAKTLYENLKFGTNPKWVNEYTLQNDLLSVKMGPRKGSKLESVDELKFYDFDPRLTWSVVLNHLQNNDADQPEKLPFSWYDWTTFHELNKLISIDKTVLPCNFLFQSAFDKESLEAIETELGEPLFLYERPKYAQKLWYKAARNQDRIKDSKELKKHCSKLFTPDGHGSPKGLRFNTQFQIKELYDKVRPEVYQLQARNYILTTQSHPLSISIIESDNSTYQVPLQTEKSKNLVQSGLLQEYINDNINSTNKRKKNKQDVEFNHNRLFQEFVNNDQVNSLYKLEIEETDKFTFDKDLVYLSPSDFKFDASKKIEELEEQKKLYPDKFSAHNENYLNSLKNSVKTSPALQRKFFYEAGAVKQYKGMGFHRDKRFFNVDTLINDKQEYQARLNSMIRTFQKFTKANGIISWLSHGTLYGYLYNGMAFPWDNDFDLQMPIKHLQLLSQYFNQSLILEDPRQGNGRYFLDVSDSLTVRINGNGKNNIDARFIDVDTGLYIDITGLASTSAPSRDYLNSYIEERLQEEHLDINNIPESNGETATLPDKVDDGLVNMATLNITELRDYITSDENKNHKRVPTDTDLKDLLKKELEELPKSKTIENKLNPKQRYFLNEKLKLYNCRNNHFNSFEELSPLINTVFHGVPALIPHRHTYCLHNEYHVPDRYAFDAYKNTAYLPEFRFWFDYDGLKKCSNINSWYPNIPSINSWNPNLLKEISSTKFESKLFDSNKVSEYSFKNLSMDDVRLIYKNIPKAGFIEVFTNLYNSFNVTAYRQKELEIQYCQNLTFIEKKKLLHQLRINVAPKLSSPAKDPFLFGYEKAMWKDLSKSMNQTTLDQVTKIVHEEYVGKIIDLSESLKYRNFSLFNITFDETGTTLDDNTEDYTPANTVEVNPVDFKSNLNFSSNSFLDLNSYGLDLFAPTLSDVNRKGIQMFDKDPIIVYEDYAYAKLLEERKRREKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKQEEEEKKKKEEEEKKKQEEGEKMKNEDEENKKNEDEEKKKNEEEEKKKQEEKNKKNEDEEKKKQEEEEKKKNEEEEKKKQEEGHSN", "function": "May function as a positive regulator for mannosylphosphate transferase. Is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.", "AFDB_id": "AF-P36044-F1-model_v4" }, { "swissprot_id": "P76909", "sequence": "MLCVKNVSLRLPESRLLTNVNFTVDKGDIVTLMGPSGCGKSTLFSWMIGALAEQFSCTGELWLNEQRIDILPTAQRQIGILFQDALLFDQFSVGQNLLLALPATLKGNARRNAVNDALERSGLEGAFHQDPATLSGGQRARVALLRALLAQPKALLLDEPFSRLDVALRDNFRQWVFSEVRALAIPVVQVTHDLQDVPADSSVLDMAQWSENYNKLR", "function": "Probably part of a binding-protein-dependent transport system YnjCD. Probably responsible for energy coupling to the transport system.", "AFDB_id": "AF-P76909-F1-model_v4" }, { "swissprot_id": "B8NI21", "sequence": "MTAPADSTEKSETSETTTLQTTEVSTVDVDPDLPRVLAKVPGTVWVVAFIAAAERFTYWGITTPWQLHAKPPQASEFARCIRPRRSESIHDIQCLHVFLLFNTNSFRDNLGRLSRSLSDIAPEFDKRFRKLPPTGNILPKAGSVLSCAIRGRFQLDAAMPSYQREHFAKEVSWDETFVNEIRRGLVACRVILGFILFFTCLSQASNNLISQAGQMKTYGIPNDTITAMNPIFCVIMGPVIQKGLYPLLNKNNVKFQSITRMATGFIMMSASMAFAAGVQKIIYDTGPCYDRPLTCPGAENGRIPNQVNVFLQTPTYIILAVAEIFSFVTLSEYTYTKAPTDMKAVVQALGQLGAAAGSAIGIAITPLAHDPSLIWMYTGLAVAMFLVAVVFWILFKKYNAIDREDK", "function": "Peptide transporter; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination.", "AFDB_id": "AF-B8NI21-F1-model_v4" }, { "swissprot_id": "Q9ZVE7", "sequence": "MAVLSTIYSITRASTPTMASLTNDSPSPLPSSSPSKLPSPTSPSKKPLKLRQVSKQMGSQNQQRRGNKPSIAQIERAFGSGSYRDSEGEMDMNTVFDELLLGHANKFESKIEKKLREIGEIFVARTEPKLRSSGKPVLMFTIQWILPIWIMSLLVACGVIKLPFSIPFLDDLIM", "function": "Probable subunit of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. Required for both formation and activity of NDH. May function in assembly or stabilization of the NDH complex.", "AFDB_id": "AF-Q9ZVE7-F1-model_v4" }, { "swissprot_id": "Q5E6C7", "sequence": "MNPIILSVSVMLILALLRVNVVVALTFSALIGGLVGGLSLSETISAFEGGLGGGATIALSYAMLGAFAVAISKSGVTDLLAHSVIKRINGKENIHAATGVKYLLLCLILLVTISSQNVVPVHIAFIPILIPPLLQVFNKLKLDRRLVACVLTFGLVTPYMILPVGFGGIFLNNILLKNLHDNHLDVLASQVPLAMALPALGMVVGLLIAVFISYRKPRTYAEVDNSELAPTSVEPTFNKRHIQISILAIIAALSVQLYAGSMIIGALAGFMVFTFGGVIAWKETQDVFTRGVHMMAMIGFIMISAAGFAAVMKATGGVETLVQALSTSIGDNKPLAALLMLIVGLLVTMGIGSSFSTIPIIATIYVPLAIAFGFSPMATIALVGTAAALGDAGSPASDSTLGPTSGLNSDGQHEHVWETVVPTFLHYNLPLIIFGWIAAMVL", "function": "Seems to be involved in glutamine transport. Complements an E.coli glnP deletion mutant.", "AFDB_id": "AF-Q5E6C7-F1-model_v4" }, { "swissprot_id": "P40571", "sequence": "MGKKAHGGKMKPEIDENGTLLVPPPRTIANQDHFHRLNYLYQISAYQTRARQKARTDAHTPLARNYIKSMDLISKKTKTSLLPTIKRTICKKCHRLLWTPKKLEITSDGALSVMCGCGTVKRFNIGADPNYRTYSEREGNLLNS", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.", "AFDB_id": "AF-P40571-F1-model_v4" }, { "swissprot_id": "G0L322", "sequence": "MKKNYLLLYFIFLLCGSIAAQDWNGIPVPANPGNGMTWQLQDNVSDSFNYTSSEGNRPTAFTSKWKPSYINGWTGPGSTIFNAPQAWTNGSQLAIQAQPAGNGKSYNGIITSKNKIQYPVYMEIKAKIMDQVLANAFWTLTDDETQEIDIMEGYGSDRGGTWFAQRMHLSHHTFIRNPFTDYQPMGDATWYYNGGTPWRSAYHRYGCYWKDPFTLEYYIDGVKVRTVTRAEIDPNNHLGGTGLNQATNIIIDCENQTDWRPAATQEELADDSKNIFWVDWIRVYKPVAVSGGGNNGNDGATEFQYDLGTDTSAVWPGYTRVSNTTRAGNFGWANTNDIGSRDRGASNGRNNINRDINFSSQTRFFTQDLSNGTYNVLITFGDTYARKNMNVAAEGQNKLTNINTNAGQYVSRSFDVNVNDGKLDLRFSVGNGGDVWSITRIWIRKVTSNSANLLAAKGLTLEDPVETTEFLYPNPAKTDDFVTVPNSEIGSSIIIYNSAGQVVKKVSVVSENQKISLEGFAKGMYFINLNGQSTKLIVQ", "function": "Cleaves the beta-1,4-linkages between beta-D-galactose and alpha-L-3,6-anhydro-galactose residues in agarose. Cleaves agarose in a random manner with retention of the anomeric-bond configuration, producing beta-anomers that give rise progressively to alpha-anomers when mutarotation takes place.", "AFDB_id": "AF-G0L322-F1-model_v4" }, { "swissprot_id": "Q8RYD6", "sequence": "MSVFESETSNFHVYNNHEIQTQPQMQTFLSEEEPVGRQNSILSLTLDEIQMKSGKSFGAMNMDEFLANLWTTVEENDNEGGGAHNDGEKPAVLPRQGSLSLPVPLCKKTVDEVWLEIQNGVQQHPPSSNSGQNSAENIRRQQTLGEITLEDFLVKAGVVQEPLKTTMRMSSSDFGYNPEFGVGLHCQNQNNYGDNRSVYSENRPFYSVLGESSSCMTGNGRSNQYLTGLDAFRIKKRIIDGPPEILMERRQRRMIKNRESAARSRARRQAYTVELELELNNLTEENTKLKEIVEENEKKRRQEIISRSKQVTKEKSGDKLRKIRRMASAGW", "function": "Could participate in abscisic acid-regulated gene expression during seed development.", "AFDB_id": "AF-Q8RYD6-F1-model_v4" }, { "swissprot_id": "Q9Y765", "sequence": "MTDSKYDYSDITPVDINTEEPQICQILYDEDYKQIMGLLLALMKAEEYSERALHITELGINELASHYTIWIYRFNILKNLPNRNLYDELDWCEEIALDNEKNYQIWNYRQLIIGQIMELNNNDFDPYREFPILEAMLSSDPKNHHVWSYRKWLVDTFDLHNDAKELSFVDKVIDTDLKNNSAWSHRFFLLFSKKHLATDNTIDEELNYVKDKIVKCPQNPSTWNYLLGIHERFDRSITQLEEFSLQFVDLEKDQVTSSFALETLAKIYTQQKKYNESRTVYDLLKSKYDPIRSNFWDYQISKLTSV", "function": "Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.", "AFDB_id": "AF-Q9Y765-F1-model_v4" }, { "swissprot_id": "Q6P4R8", "sequence": "MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPATATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTSAPSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ", "function": "Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.", "AFDB_id": "AF-Q6P4R8-F1-model_v4" }, { "swissprot_id": "Q750C9", "sequence": "MMAADDTMSSKRADNCYKKDRGTMVYTPTDAQQATGKVHEKVYKFFESLYWMYYIHLPYYLMTSFDSFCLHVFFLVVFTLSLFGLLKWVLSLYWATVGYMAYAATGQ", "function": "Stimulates the activity of serine palmitoyltransferase (SPT).", "AFDB_id": "AF-Q750C9-F1-model_v4" }, { "swissprot_id": "A0A0M4FMK2", "sequence": "MGSLNNEVGSIKCEVGSLKSENSFTKLPSEESLASESKKVTPVSSDFELNCGSLAPTSLSFPAMKFEDDIEIQSPDNSIWESFFADHLEGDFMISSPVRNLPSPQPASSFSSSHNNGNNNNNNYNIYAHRQGIHGQDMMMCSPPRSPLGLYNHPSHKGKGLSPLQKVFNSPNNQFMQIESFNLPALESFLDDDYDKEEDLASSYSTLKVSGTGVAGSSSESFDALSVVPDDLLECLALPSSLSNTSGGFMESLLSDTSAVQVINPDDEIFRTGSIAPLSQQLHQERQQEKQQKQRPVTHARPQQQQIINHNVLVPLAAAPDQEQDSGLQLVHLLLACAEAVSKEDYMLARRYLHHLNRVVTPLGDSMQRVASCFTEALSARLAATLATKPSTSALKPFNPFPPNSLEILKIYQILYQACPYVKFAHFTANQAIFEAFEAEERVHIIDLDILQGYQWPAFMQALAARPGGAPFLRITGVGPSPEAVRETGRCLTELAHSLHVPFEFHPVGEQLEDLKPHMFNRRVGEALAVNSVNRLHRVPVNCIGNLLAMIRDQAPNIVTIVEQEASHNGPYFLGRFLEALHYYSAIFDSLDATFPADSSQRAKLEQYIFAPEIMNIVSCEGPERVVRHERLEKWRRLMEGKGFKGVALSANAVTQSKILLGLYSCDGYKLTEDDGCLLLGWQDRAILAASAWRC", "function": "Transcription factor acting as a central regulator of arbuscular mycorrhiza (AM)-related genes involved at later stages of symbiosis (e.g. VAPYRIN, PT4, PT5, STR, STR2, RAM2, SBT and BCP) but not required for early genes of AM (e.g. common symbiosis signaling genes). Required for the morphogenesis of arbuscules upon symbiosis with AM fungi (e.g. Rhizophagus irregularis, Simiglomus hoi and Acaulospora scrobiculata). Also involved in restricting mycorrhizal colonization of the root meristem.", "AFDB_id": "AF-A0A0M4FMK2-F1-model_v4" }, { "swissprot_id": "O06836", "sequence": "MLHAFERKMAGHGILMIFCTLLFGVGLWMHLVGGFEIIPGYILEFHVPGSPEGWARAHSGPALNGMMVIAVAFVLPSLGFADKKPHLLGNIIILDGWANVGFYFFSNFSPNRGLTFGPNHFGPGDIFSFLALAPAYLFGVLAMGALAVIGYQALKSVGSRKAVPHATAE", "function": "Epoxystyrene isomerase that catalyzes the second step in the aerobic styrene degradation pathway by converting epoxystyrene to phenylacetaldehyde.", "AFDB_id": "AF-O06836-F1-model_v4" }, { "swissprot_id": "A9NHF8", "sequence": "MLYSIGKVVQTHGIKGEVKIKPHTDFDRFVKGFDVIIKDTKYKIQTVREQKDLLLVSFVGYPTLTDVEHLKQQEIYTDEEPLDLESDAFHLPKLIGLKVYDQHNYLIGTVLELVDVPQGYLLRILRDDNGKTVLIPFIDKFIKSVDETSIHIETIEGLI", "function": "An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.", "AFDB_id": "AF-A9NHF8-F1-model_v4" }, { "swissprot_id": "P21997", "sequence": "MSKLLLVALFGAIAVVATSAEVLNLNGRSLLNNDDPNAFPYCKCTYRQRRSPYRLKYVGAENNYKGNDWLCYSIVLDTTGTVCQTVPLTEPCCSADLYKIEFDVKPSCKGTVTRAMVFKGIDRTVGGVRVLESISTVGIDDVTGVPGAAILRIVKDLALPYSVVASFLPNGLPVCINRVPGSCTFPELFMDVNGTASYSVFNSDKDCCPTGLSGPNVNPIGPAPNNSPLPPSPQPTASSRPPSPPPSPRPPSPPPPSPSPPPPPPPPPPPPPPPPPSPPPPPPPPPPPPPPPPPPSPSPPRKPPSPSPPVPPPPSPPSVLPAATGFPFCECVSRSPSSYPWRVTVANVSAVTISGGAGERVCLKISVDNAAAATCNNGLGGCCSDGLEKVELFANGKCKGSILPFTLSNTAEIRSSFSWDSTRPVLKFTRLGLTYAQGVAGGSLCFNIKGAGCTKFADLCPGRGCTVAVFNNPDNTCCPRVGTIA", "function": "The extracellular matrix (ECM) of Volvox contains insoluble fibrous layers that surround individual cells at a distance to form contiguous cellular compartments. SSG 185 is the monomeric precursor of this substructure (C3Z structure).", "AFDB_id": "AF-P21997-F1-model_v4" }, { "swissprot_id": "Q2NQZ7", "sequence": "MATRLQDGNSISPEPMLSDGSAAKRPTILVFDSGVGGLSIYNEVRQTLPNAHYLYVFDNEAFPYGEKPEQFIVDRVVAIVGAMWRQHKIDLVIVACNTASTISLPALRERFPCPIIGVVPAIKPAARLTRNGIVGLLATRATVQRSYTHDLISQYAGDCQILQLGTAELVDMAEARLHGELVPLPVLRKLLRPWLRAAEPPDTVVLGCTHFPLLSQELQAVLPEGTRLVDSGSAIARRAAWLVEHDMDVSSLQGETGPNKTYCLVTTPQAVALMPALTRYGFGSSGMLTL", "function": "Provides the (R)-glutamate required for cell wall biosynthesis.", "AFDB_id": "AF-Q2NQZ7-F1-model_v4" }, { "swissprot_id": "Q8TQ11", "sequence": "MLITTSRKPSAKTRTLCKLLSRFITGRCITRGKMGMQELIGFAEGGPLIVVGEYHGNPGELGFYDDAGKLLFSLRFSDWYSEDIGSYWFPDLEPVLAGQGEIADAFESFFHFKRVESEEVDQLPPLSTVLVAGEKEIDFTGSGKSLFKLNVKGFKKY", "function": "Probably involved in the biogenesis of the ribosome.", "AFDB_id": "AF-Q8TQ11-F1-model_v4" }, { "swissprot_id": "P25545", "sequence": "MAPHWTLRQLRLVALAAASGSYAKAAQDMGLSPPAVTAQMKALEEDIGVPMFERVDGRLRPTAAGQELLSAQERIARALSEAERAIAALKSPERGSVVVGVVSTAKYFAPMALAAFRRRRPEIELRLIIGNREDIIRGIVSLDFDVAIMGRPPPALEAETRLIGDHPHIVVAPVDHPLFKRRKRITPADLTRESLLVREPGSGTRILMERVFEEAGAPNPPIAMEIGSNETIKQSVMAGLGLAFISAHTVAAEVADGRLRVLEVEGLPVVRQWLAVRARDKRLLPAGQALMDFLEREGASFLPQMPGGEGGRCYLPDHVSGSTPAKAVARDPV", "function": "Transcriptional activator for the cbb operon (cbbLSXFP) for RuBisCO and other Calvin cycle genes. Binds specifically to two binding sites in the cbbR-cbbL intergenic region.", "AFDB_id": "AF-P25545-F1-model_v4" }, { "swissprot_id": "P42880", "sequence": "MQSGRVIMIVGNGDVPEGAAATIDAADLVIRFNDCRSVGKGGSRTDIIAVCNTGRPALSMLGGGRWKTSAAVRQARELWSVRSGARFAAMRAALAGTHPDLDDFCDDYTAGFESFARATARKHRVIAAETHDRLERDLARFAPSPYVAPSSGLVVIADIVSSFAAAGDDVVLAGFGHIGWQWHPFAAERRYVDALAAQGRLRRLHPFASSDLPQGA", "function": "Involved in the expression of hydrogenase activity. May be a regulatory gene affecting the expression of the hydrogenase operon or could be involved in the process of nickel incorporation into the hydrogenase apoenzyme.", "AFDB_id": "AF-P42880-F1-model_v4" }, { "swissprot_id": "Q57UZ7", "sequence": "MEGSHSSNMERLEYLYLNLVGQVVQVRLVDDMCVEGLFVACTDVDAETDAGIMICCTRNLASAKRSPLSPSCVNFTDDLFIPYQSIVMIEVQNAKIRTETPGRPDTGRADFSATKFDWADDGVSELLESEPHQTGTWNQFEANEKSFGVKTTYKEEFYTTRLDHSKITEEQRAQADRLAREIESSSTRGIAHRMEREECLHDDEGLDEGQLYSDVHRPQEKKPPYVPPSTGGRKLVNEPPPVPAAAAPATAPTTAPAAAPAPAAAPPAAAPAAAAPPPPPAATSMADDGSMRHKRMNEDPHHMQYDANQTAAGFNPAAAPYTPMKPGAAVPVVDFLASLADAISNNDMCYDCEPHWPGMCNLFYDQDDSSYSQQNYEAAAMPPSHSMNMHMYVNSQPNIPNAHRGYQGPLGRVPHNQSMPMHHMQGQGFHHEMHHHQAFHGMGNYSSQHHNPPIQEYAPHKGQQGVVSRPGMRQGKGGGASRVEPQQPVSANTASSPPPVPTVDSAPNEVKPPAKLQRGRGMAAFTKGDMDGDSGATTNATGGPKKRVGK", "function": "Involved in post-transcriptional regulation of gene expression. Promotes mRNA stabilization by bridging poly(A)-binding protein to mRNAs.", "AFDB_id": "AF-Q57UZ7-F1-model_v4" }, { "swissprot_id": "Q9KEI9", "sequence": "MAKSKYYVVWNGRKPGIYTSWSACEAQVKGYTGAKFKSYPSKEEAEAAFRGEEATPKLAKEEIIWESLSVDVGSQGNPGIVEYKGVDTKTGEVLFEREPIPIGTNNMGEFLAIVHGLRYLKERNSRKPIYSDSQTAIKWVKDKKAKSTLVRNEETALIWKLVDEAEEWLNTHTYETPILKWQTDKWGEIKADYGRK", "function": "Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.", "AFDB_id": "AF-Q9KEI9-F1-model_v4" }, { "swissprot_id": "Q1QWN5", "sequence": "MSRMISLREAETLAVAALEAVGVPRWEAEVTARALIDAERDGLASHGLSRLPFYLAQARSGKVVADAQARVEVAGSVIRVDARHGLAFPAIARGVERAIPLARELGLVAVAIGGSHHFGVAGAPVERLAREGLVAMAFSNAPSAMAPWGGKRPLYGTNPIAFATPRRGTDPLVIDLSLSKVARGKVMLAKKAGEPIPEGWALDIEGRPTTDPDAAIAGSMVPAGDAKGASLALMVELLTAGLTGSHFGFQASSFFEPEGEAPSVGHLMLAFDPAHFSDGYLEHIEALFQAMLEQEGVRLPGTRRHALRRERGESLELPEAVVDELRAYAVSRV", "function": "Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate. Together with SlcC, provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by (2R)-sulfolactate sulfo-lyase.", "AFDB_id": "AF-Q1QWN5-F1-model_v4" }, { "swissprot_id": "Q6NUQ4", "sequence": "MATKTAGVGRWEVVKKGRRPGVGAGAGGRGGGRNRRALGEANGVWKYDLTPAIQTTSTLYERGFENIMKRQNKEQVPPPAVEPKKPGNKKQPKKVATPPNQNQKQGRFRSLEEALKALDVADLQKELDKSQSVFSGNPSIWLKDLASYLNYKLQAPLSEPTLSQHTHDYPYSLVSRELRGIIRGLLAKAAGSLELFFDHCLFTMLQELDKTPGESLHGYRICIQAILQDKPKIATANLGKFLELLRSHQSRPAKCLTIMWALGQAGFANLTEGLKVWLGIMLPVLGIKSLSPFAITYLDRLLLMHPNLTKGFGMIGPKDFFPLLDFAYMPNNSLTPSLQEQLCQLYPRLKVLAFGAKPDSTLHTYFPSFLSRATPSCPPEMKKELLSSLTECLTVDPLSASVWRQLYPKHLSQSSLLLEHLLSSWEQIPKKVQKSLQETIQSLKLTNQELLRKGSSNNQDVVTCDMACKGLLQQVQGPRLPWTRLLLLLLVFAVGFLCHDLRSHSSFQASLTGRLLRSSGFLPASQQACAKLYSYSLQGYSWLGETLPLWGSHLLTVVRPSLQLAWAHTNATVSFLSAHCASHLAWFGDSLTSLSQRLQIQLPDSVNQLLRYLRELPLLFHQNVLLPLWHLLLEALAWAQEHCHEACRGEVTWDCMKTQLSEAVHWTWLCLQDITVAFLDWALALISQQ", "function": "Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.", "AFDB_id": "AF-Q6NUQ4-F1-model_v4" }, { "swissprot_id": "Q6BK42", "sequence": "MRLTISNESNNQILSVDISESMTLEDFQAYIQAEFDISPQDQSLKHNGKPLSGSDKSLEDLGLNNDDLVLLGKTSVGSTTASSGSSVTANSNNSNAVDFQIEAMRTQFLSNPQLNSQLRQSNPQLHSTLNNPSEFKNSVIGSLQQFQNGATPGSYNPQQQEQLSRLQDNPDDPESQSRILEMIRQERIDENMQLAYEIAPESFTSVNMLYINIKVNGVLVQAFVDSGAQSTIISPKLADKCGISRLIDRRFVGEARGVGSQKIEGKIHSVPIAIGDSDTHIPCSFIVIDTHVDLLFGLDMLRRHKCVLDLERDVLVVGGNIETKFLHESEIQANPFLPGVAGSSASAGGTGGTFGGQGIALGSNSAENNNVTSSIVPANSTPDTTKQKAPNAAANAAVKRQDTGNSSSKFSESDIKQLVSLGFSKQEAIFALEQSQGNVEVAASLLFQ", "function": "Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.", "AFDB_id": "AF-Q6BK42-F1-model_v4" }, { "swissprot_id": "Q8SX68", "sequence": "MEQNSNSSVADTFAEAPATDADYGTENCSGSGMSVGDTVSANHEFQTMKPGPGVVHKVMPVANSASSATATNGRTRSEMPHSELVKMLYYLEGELQARDVCIAALRNERVKQLIAQLRTKRLQPNDPYAAIFRDKIALNGNLISRESSTQAAQAEMEVRQIIEQQMEQQYQMVSKQRATHVRMVNILTESLENNQRMLQELEEEKRKHENTTAQGDDITYGLELERNKLKQDLEEERAQVAKMEKDLKKLQETLEYERNRQKQIVLLLIAERKKILMKYIEEGKRSEDLAQILAEEKQRSDTIAEGLEEESKKSLRMEEELEKQTHAMEQERKVLFAKLAKEELRVKELEQELNALRSEHEALKKQQQLGGSGSSVAAAKARQFSDDACATPPMVNIAKIVQPTATVSSMPVSGPQTGIARSIAPGQNIRSAGIATAPTGTATAAIAPLTAVLNHTTTITTTTNNTTTSSNSNSSGSIGVAATAAAVAASVETAATVTVPMVAPPSPSPAKMQPTATIQRAPGGKYAALAAAAALDQTTTPHPHPVPIAVPPVTVPPAGARGAPPPIPTKPIVPPKREPSLSRLGSITGSSAIAAATAATTAAGTAKQN", "function": "Regulates lamellipodial actin dynamics in a Cortactin-dependent manner and is therefore likely involved in controlling actin branch density, actin-retrograde flow rates and lamellipodial protrusion. Functions by slowing the dissociation of Cortactin from Arp2/3 nucleated branches thereby increasing branch nucleation and junction stability.", "AFDB_id": "AF-Q8SX68-F1-model_v4" }, { "swissprot_id": "Q94A15", "sequence": "MDIRKRKNAGGDGDGGADGASVNVGDEPDSFGGRIGSPRRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVKSILFLMPCHSTPYYSTLHRNIPMQFLDCTPSAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEVRRFFHAHFKVDRDLQSSVVVYVVNHAFP", "function": "Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Required for the pollen tube micropylar guidance and embryo development by regulating GPI-anchor mediated protein localization (e.g. COBL10 and A36).", "AFDB_id": "AF-Q94A15-F1-model_v4" }, { "swissprot_id": "D4GP37", "sequence": "MSQSSSTGNFDVASLVEDVNLRRVAQYALVVFFLGFFLVPLETGIMTAIKTNESVARSLPFAPPVGEGFTLGNIQFALEQLSGSFFNSLIMSIPATIGSVLFGSMAAYGLTMVNWRAQMGMLMLFVVGVFVPYQAVLVPLARFWNNIFPLARMIEPMVASIPFFQGYHAELVPLVITHIAYGIPICTILFRSYYQSLPNSLVEAGKIDGASITKIYRRIILPISKPMFGVVFIYQFTQIYNEFLFAFTLVTGSDAPAAPVTLVLPAIGASTSGINFGIRMSAAFLAAVPTLILYVAFAEQFAKGLRTEA", "function": "Part of the ABC transporter complex XacGHIJK involved in the uptake of xylose and arabinose. Responsible for the translocation of the substrate across the membrane (Probable).", "AFDB_id": "AF-D4GP37-F1-model_v4" }, { "swissprot_id": "Q9S814", "sequence": "MEAEIVNVRPQLGFIQRMVPALLPVLLVSVGYIDPGKWVANIEGGARFGYDLVAITLLFNFAAILCQYVAARISVVTGKHLAQICNEEYDKWTCMFLGIQAEFSAILLDLTMVVGVAHALNLLFGVELSTGVFLAAMDAFLFPVFASFLENGMANTVSIYSAGLVLLLYVSGVLLSQSEIPLSMNGVLTRLNGESAFALMGLLGASIVPHNFYIHSYFAGESTSSSDVDKSSLCQDHLFAIFGVFSGLSLVNYVLMNAAANVFHSTGLVVLTFHDALSLMEQVFMSPLIPVVFLMLLFFSSQITALAWAFGGEVVLHDFLKIEIPAWLHRATIRILAVAPALYCVWTSGADGIYQLLIFTQVLVAMMLPCSVIPLFRIASSRQIMGVHKIPQVGEFLALTTFLGFLGLNVVFVVEMVFGSSDWAGGLRWNTVMGTSIQYTTLLVSSCASLCLILWLAATPLKSASNRAEAQIWNMDAQNALSYPSVQEEEIERTETRRNEDESIVRLESRVKDQLDTTSVTSSVYDLPENILMTDQEIRSSPPEERELDVKYSTSQVSSLKEDSDVKEQSVLQSTVVNEVSDKDLIVETKMAKIEPMSPVEKIVSMENNSKFIEKDVEGVSWETEEATKAAPTSNFTVGSDGPPSFRSLSGEGGSGTGSLSRLQGLGRAARRHLSAILDEFWGHLYDFHGQLVAEARAKKLDQLFGTDQKSASSMKADSFGKDISSGYCMSPTAKGMDSQMTSSLYDSLKQQRTPGSIDSLYGLQRGSSPSPLVNRMQMLGAYGNTTNNNNAYELSERRYSSLRAPSSSEGWEHQQPATVHGYQMKSYVDNLAKERLEALQSRGEIPTSRSMALGTLSYTQQLALALKQKSQNGLTPGPAPGFENFAGSRSISRQSERSYYGVPSSGNTDTVGAAVANEKKYSSMPDISGLSMSARNMHLPNNKSGYWDPSSGGGGYGASYGRLSNESSLYSNLGSRVGVPSTYDDISQSRGGYRDAYSLPQSATTGTGSLWSRQPFEQFGVAERNGAVGEELRNRSNPINIDNNASSNVDAEAKLLQSFRHCILKLIKLEGSEWLFGQSDGVDEELIDRVAAREKFIYEAEAREINQVGHMGEPLISSVPNCGDGCVWRADLIVSFGVWCIHRVLDLSLMESRPELWGKYTYVLNRLQGVIDPAFSKLRTPMTPCFCLQIPASHQRASPTSANGMLPPAAKPAKGKCTTAVTLLDLIKDVEMAISCRKGRTGTAAGDVAFPKGKENLASVLKRYKRRLSNKPVGMNQDGPGSRKNVTAYGSLG", "function": "Trafficking signal inducing ethylene response. The nuclear localization is both necessary and sufficient to activate EIN3-mediated transcription and ethylene responses. Involved in ethylene (ET)-mediated signaling pathways by triggering histone acetylation of H3K14 and H3K23 in an ENAP1-dependent manner, thus influencing the expression of ethylene-responsive genes. Necessary and sufficient for 3'-UTR-mediated translational repression of EBF1 and EBF2 mRNAs. Ethylene induces EIN2-CEND to associate with 3' UTRs in cytoplasmic foci and target EBF1/2 mRNAs to cytoplasmic processing-body (P-body). MPK6 regulates the cleavage and nuclear translocation of EIN2-CEND under methyl jasmonate treatment. Required for EIN3 accumulation.", "AFDB_id": "AF-Q9S814-F1-model_v4" }, { "swissprot_id": "D0ZI38", "sequence": "MPISICKHGAPFVVQHENRYGSGASQSSSLSKSIRHISNSHEEIKFISCYSANGACFSNAQMLANASGRPVIGYYGKINKLTASLDNSGRIFRPQHKLAANICYVGNRLLSAPVQLGFGLKHLLTCHSNGNVR", "function": "Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.", "AFDB_id": "AF-D0ZI38-F1-model_v4" }, { "swissprot_id": "O66810", "sequence": "MRTVDITTKIETLREAKAYGRIRLKPETVKLIKENKVPKGNLVEATKLSGIFGAKKTGELLPFCHPIPLDFVALEVKVNEDNLEVFSTVRGIARTGYEMEALTAVTTALLNVYDMCKALDDSMVIEEVKLLEKSGGKSDWFRRLDGVKVNLHAENEGLRKIAEDYLKELGATFAEEAELYISIGDNLPINKEIRSLERVISLYDFRRNPKEVGKEIRVGWSDDALIIILPESEEKIRFFFETFGGIIGNLLCRR", "function": "Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).", "AFDB_id": "AF-O66810-F1-model_v4" }, { "swissprot_id": "P01174", "sequence": "MRCSISLVLGLLALEVALARNLQEHVFNSVQSMCSDDSFSEDTECINCQTNEECAQNDMCCPSSCGRSCKTPVNIEVQKAGRCPWNPIQMIAAGPCPKDNPCSIDSDCSGTMKCCKNGCIMSCMDPEPKSPTVISFQ", "function": "Could be a protease inhibitor.", "AFDB_id": "AF-P01174-F1-model_v4" }, { "swissprot_id": "A0A286YDK6", "sequence": "MAAGVIRSVCDFRLPLPSHESFLPIDLEAPEISEEEEEEEEEEEEEEEEEEVDQDQQGEGSQGCGPDSQSSGVVPQDPSSPETPMQLLRFSELISGDIQRYFGRKDTGQDPDAQDIYADSQPASCSARDLYYADLVCLAQDGPPEDEEAAEFRMHLPGGPEGQVHRLGHRGDRVPPLGPLAELFDYGLRQFSRPRISACRRLRLERKYSHITPMTQRKLPPSFWKEPVPNPLGLLHVGTPDFSDLLASWSAEGGSELQSGGTQGLEGTQLAEV", "function": "Plays a critical role in intestinal function by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas. It is thereby required for normal enteroendocrine peptide hormone secretion.", "AFDB_id": "AF-A0A286YDK6-F1-model_v4" }, { "swissprot_id": "Q5AXA9", "sequence": "MTPSASPSPSPNPGDANVKVDADSPNDFILFSHELPSGDIQDLIRRLHRYGTLPGYPHLARFLQECALLLRTEIQKLPRALRDSVPPFHDVVTLASHWDRLKSGPLSGAWDGPFLCLYEIAMLIGHHETHQLSYRRPACLVGISVGLFSAAAVAVSKSISDLVSYGAESVRTAFAFCVHVQRVSQELEPTMTEQAASVSWATVVIGVPADTIQVELDRFNHLKESESPGANARPLTGVSISHVDQTSVGVTGPPSRLKQLFRQSELLRSSRHSALPISGGLCHVPNVYDDEDVRAILEMAEVWEKWGTRALQVPLISPFTGSPFLCPDAYHLIEAICTEALTKQLYFDKLAGGVVTQLNGLSCQVLHYGASLMSDTIIDDVTSQLSPCDTARQCLVDWALRDAFDQLPGGPTPPRDAKLAVVGMACRMPGGADTPDHFWELLMNGVDTHTTVPPDRFDLDAHFDPSGEKENTTTKGSQSNRPLSRQAEQTDPMQRLALVTAYEALEMAGFVPNRTPSSHLSRVGTYYGQASDDYREVNAGQKIGTYGIPGTERGFGNGRINYFFNFQGPSFNIDTACSSGLAAVQAACSALWAGEADTVVAGGLNVITSPDIYCMLSKGHFLSKTGQCKVWDIGADGYCRADGIGSVVIKRLDDALADNDVILACISAGATNHSAESISITQPHAAAQRENYRQVMDRAGVSPLDVSFVELHGTGTQVGDAVESESVLSFFAPLGRRSHPDKRLHLGAVKSNIGHGEAAAGIASLIKVLLMYRNNTIPRHIGIRTAMNPVVAQHLANRNAGILSENHPWLAATASKKRYAIVNSFGAHGGNTTLLLEDAPSQHSQRYKNHSRRVVASSEVVCTSAKSKASLRANIRALLAYLDTHQETDLRDLAYTTSARRMHHHIRIASSVTSTAQLRSFLQAAADDVDAYAKHIATATKRTAVFAFSGQGCLYHGAAAHLFEQAPLFRNQVLQLDRIVRRLGFPSILVTVAGDAASVYDSARCPHRESTPSSDASHDSNTNRTSTAPAVDSPLIAQLALVVIQIALVQYWGLLGIKPSVVIGHSLGEYAALVAASVLSVADALFLVGKRAELMLAVCEPGSHAMLSVRGASVDRIEELCRESEKRYPFEVSCVNGLTDLVVTGLRGDMASLRDLLQGSGLKCVLLDIPFAFHSKQMSPILEDFENAAQQITFQEPAVPVISPLLGKCISEANVINGKYLARATREPVDFVAALDSAWADGTVNDKSIWIDIGPHPVCTSFASNHYGKAATQSFASLRRGDETLSTLTATLAALHCLGLPVDWNEYYDLRENPARLLHLDSYQWNYKNYWIPYEGSWTLDKAHAGQNNKTKDDNSAVTPAFFTSSVQQIIFEEYDESMGRMEALSDLHHPDLQGAADGHKIHGRSVVTGSIWADITLTVGEYLYKQMVPGGKMPHMNVKGMEVLEAQVLHPDMSQFIQIEGVLDLPRQQTAVRLYAASANGTRNTDKPFASATVCYEEAQDWQDQWQMTSHLVAARANSFWEMAAGGSDDNARPAGKGGPRVNNFFRSIAYQLFANVVDYGARYRGMQRVALSEDTLEATADIVLDKDRHGTWHTPPHWIDSAFQLAGFVMNSFGVQGDGKISGSSRDFFYITPGWRHFRLLERLEPGPEATYRSFVRMFPVGSEPGAYSGDIYLHRGKRLVGVCAGIKFKAVPRALMPVLFPRIEPQAGKRRNQAQTAENRLVKGKGNCEYTHTVFQEPKSRTPAYDVTKSQPHAEHCDISISQKTQPVAAVPVTQPALPAKERGEQNQGQSQSQNAQATACLSLISDETGLDLDDLTGEAAFADLGVDSLMSLALSAKIRAELGIDVQSSIFLECPTVQDLVTWLSK", "function": "Non-reducing polyketide synthase; part of the pkg gene cluster that mediates the biosynthesis of dihydrocitreoisocoumarin and 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin. The non-reducing polyketide synthase pkgA performs the condensation of one acetyl-CoA starter unit with 6 and 5 malonyl-CoA units, respectively. As pkgA lacks a releasing domain, the thioesterase pkgB is necessary to break the thioester bond and release dihydrocitreoisocoumarin and 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin from pkgA.", "AFDB_id": "AF-Q5AXA9-F1-model_v4" }, { "swissprot_id": "A4TM82", "sequence": "MSKENIVTRENTAVSENAVSEPTVNNDVGASATNSVTHPAFTLNVRPDNIGIITIDVVGDKVNTLKAEFADQIATILQQAHALPKLQGLVIVSGKPDSFIAGADITMIAACRTAHDARVLAQKGQSILAQIAAFPVPVVAAIHGACLGGGLELALACHSRICSLDDKTVLGLPEVQLGLLPGSGGTQRLPRLVGVSKALDMILTGKQIRPRQALKMGLVDDVVPRDILLDVAIQRAKAGWLNRRALPWQERLLSGPLGKALLFRIVRKKTLAKTRGHYPAAERIIDVVRKGLDQGGPSGYEAEARAFGELAMSPQSAALRSLFFATTSLKKETGSAATARAIHRVGVLGGGLMGGGIANVTATRAGLPVRIKDINPQGINQALKYTWDALGKRVRSKRMRPTEQQRQMMLISGSTDYRGFERVDIVVEAVFEDLSLKQQMVADIERFGAAHTIFASNTSSLPISQIAALAQRPEQVIGLHYFSPVDKMPLVEVIPHEKTSEETIATTVALARKQGKTAIVVADRAGFYVNRILAPYINEAARCLLDGEPIESVDNALVDFGFPVGPMMLLDEVGIDVATKIMPILVEQLGPRFAAPPSFDVILKDGRKGRKNGRGFYLYSNPTKNSSPTKNGNSPAKRNSFKWRKNKVKPVDASIYTLLGVTPKAHLGAGVITQRCTMLMLNEAVRCLDESIIRNPRDGDIGAVFGIGFPPFLGGPFRYLDSLGADKVVQALRLLVQQYGERFEPCQRLVTMAEQQQQFYPVDANIDEVTDVAS", "function": "Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.", "AFDB_id": "AF-A4TM82-F1-model_v4" }, { "swissprot_id": "Q9CQS9", "sequence": "MAAANPWDPASSQTAAGLLLNHLVASGIVTKEMLDVSKKMAPCFVNFSRLQQISDIQAEIYQNNLELELLKLEKDTADLIHPSHLIEKCDVLQSMNNHLEAVLKEKHAIRQRLLRPMCQENLPLEAVYHRYVVHMLDLAVTFIEKFETHLETVKNSPHLDANLKQMSKALAKMDILVNKTEELAENILKWRELQTEISLYIPKMLTEERHLHELDIVPPLPFFPKAHTETSRAK", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.", "AFDB_id": "AF-Q9CQS9-F1-model_v4" }, { "swissprot_id": "A8MB38", "sequence": "MIVRINKSVAFGSVKAPRSKSWAIRLILLSAISDEETTICSIPDSDDTEAALRMIEVLGSKVIRQGNCIRVIPNLRQCGGYVNVGGSGTVMRLGVALASSCRNPVIIDGDETLKRRPIRELLESLRSLGVNVNGDSLPVAINGPVKGNYVEIRGDLTSQYISGLIMLGLVSGITIRVIGDLVSRQYVDLTRRIIEESGCSVGVSNDVITVNECIPRISLSNVPGDYALSGFYTALALATGGLVTVTGLPKPLGYGDDSLVNIFSNAGARSVFSNGDWSVEGGGELRGIVVDLKDSPDLAPVVASIAPFASGETVITGVRHLAFKESNRLETISDSLRAFGVNVNHGDDSLRISGSITHGALIKCPNDHRIAMMSGVVAAGSNGESIIHNAECVNKSNRLFWRDLVKLGVKLTIN", "function": "Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.", "AFDB_id": "AF-A8MB38-F1-model_v4" }, { "swissprot_id": "E2JA29", "sequence": "MHSVETFNLPALNSLLETTARRFGNRLAVQDDNGSLTFADFVEKVGILSAKLRLVIKRGEHVAVQLPRGINYIVAAYAIWEAGGVYLPLDNQWPSSRIEGILHRSHVRVLIHTSQADQGLELTELPAETRAESPVAGTPAYIIHTSGTTGEPKGVVVSHESLIHLVESHQRDIYQAYDVTEGPVAINASFCFDSALERMALVALGYSLHVVSDQVRKSPYELVKYLRDNSIVNVDLVPSHLKVLLSAGLNEKCDALRLVIVGGEAIDAELWREIVQNQAIYINVYGPTENTINTSFCEIRGETPHIGRPFKNVTCLLLNENGERCAAGEEGELLVAGRHLAQGYYNAPDLTDRVFVHIDGIRYYRTGDRVRQNEQGNLLYLGRIDDQVKINGFRIELADVQHNLTQLPGVKYAAVTPIKLPTGQGLLASIVWNSDAPEQTFSNLEALLGEKLPSYMVPTRWQKLDALPLTDNLKLDHKSLLSHWKNSQEQIGEKFAAESISATEHQIKNLWQKILRQPSLSPDAHFFASGGDSMAAMTLLVELKKVTPQDVSLGDIFKYPTIRKMAAWLDASSVQAES", "function": "Involved in dapdiamide antibiotics biosynthesis. Activates and sequesters N-beta-fumaramoyl-DAP as a covalently tethered thioester for subsequent oxidative modification of the fumaramoyl group.", "AFDB_id": "AF-E2JA29-F1-model_v4" }, { "swissprot_id": "A7I006", "sequence": "MKHYEVLFIVKPTLQDDEVKTKVDFVKEVITKNGGEIAAVVEMGTRKLAYKIDKYERGVYFVIYFTAPTKLIAELVRNLRINEDIIRFLTIKYENKKEISAWEKLSHGVKLSENMKKNERKAPKEPVKKDEEENKESEEEITSEE", "function": "Binds together with S18 to 16S ribosomal RNA.", "AFDB_id": "AF-A7I006-F1-model_v4" }, { "swissprot_id": "Q8IRJ8", "sequence": "MSEQCQLRPHSDTLVRKLVEMNDEEIIKQRLLIDGDGTGEDRRIVVLLKQFLKWASDSLDSNPIMYDRLMAQFAQCKLTALKNVQTLQMIAGERDNYTQLVEHHEESIVLAKAEIESSKKELITAKQIRKNKMEYDLLASLIQDQPDRSETQRHIETIRREIDDLVQKKLKMERKFQKRRNDFTLLMYTIHELEQQLDQDSSSSASSSSSDCDARSEPDLDDNGIMEVSDEDDDLNNSTPTKFDGARGEPKYHSVSTEDSKAMSVEEDTVLELSIDKDEHDVDVAVAN", "function": "The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress.", "AFDB_id": "AF-Q8IRJ8-F1-model_v4" }, { "swissprot_id": "C7DQY0", "sequence": "MMFRLTSVSCFLLVIACLNLFQVVLTSRCFPPGIYCTPYLPCCWGICCGTCRNDNSSLTFLQFCLPFFFFLRPSHPLFLLLPAR", "function": "Inhibits the vertebrate voltage-gated potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3.", "AFDB_id": "AF-C7DQY0-F1-model_v4" }, { "swissprot_id": "Q96RD6", "sequence": "MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF", "function": "Structural component of the gap junctions and the hemichannels.", "AFDB_id": "AF-Q96RD6-F1-model_v4" }, { "swissprot_id": "P39927", "sequence": "MTDPRRRTGRHFLTPENLSSTLQITNLPPEWNQDIITSVVAGSGPVIDIKAKNDPRTGKLTGVLFDYLTSKDCKRAWEILNRIENFPVKIEQIIPPNYKDHLRETANKNSQKQVLQLNRDSYPFEAGLELPFEMVTEVPIPRRPPPPQAANNTNSVSNNTNIQFPDILSKASKHLPSFQDGSIIAPDKISQNLSKIPPLQLIEIISNLKILSNQENIQKSQLESFLDTNSDITISVTQALLEMGFIDYSVVTKVLKSQVGEAPSLLSSNNTSNSNTPVSVIRNNTPLHVPSNEVSNNPNNMPLNVAMPMPMSTPPFIPLPLQQQPFGFAPPGPFMPPAQGPSMGQPVLANQLGQVQQQNISSTEGPSNANKANDSGTINMAKLQLLPENQQDMIKQVLTLTPAQIQSLPSDQQLMVENFRKEYII", "function": "Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. PTI1 is required for 3'-end formation of snoRNAs.", "AFDB_id": "AF-P39927-F1-model_v4" }, { "swissprot_id": "Q9CAN8", "sequence": "MELLDMNSMAASIGVSVAVLRFLLCFVATIPISFLWRFIPSRLGKHIYSAASGAFLSYLSFGFSSNLHFLVPMTIGYASMAIYRPLSGFITFFLGFAYLIGCHVFYMSGDAWKEGGIDSTGALMVLTLKVISCSINYNDGMLKEEGLREAQKKNRLIQMPSLIEYFGYCLCCGSHFAGPVFEMKDYLEWTEEKGIWAVSEKGKRPSPYGAMIRAVFQAAICMALYLYLVPQFPLTRFTEPVYQEWGFLKRFGYQYMAGFTARWKYYFIWSISEASIIISGLGFSGWTDETQTKAKWDRAKNVDILGVELAKSAVQIPLFWNIQVSTWLRHYVYERIVKPGKKAGFFQLLATQTVSAVWHGLYPGYIIFFVQSALMIDGSKAIYRWQQAIPPKMAMLRNVLVLINFLYTVVVLNYSSVGFMVLSLHETLVAFKSVYYIGTVIPIAVLLLSYLVPVKPVRPKTRKEE", "function": "Lysophospholipid acyltransferase with broad specificity. Mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes the acylation of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Can convert lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Exhibits preference for C18-unsaturated acyl-CoA when transferring an acyl group to lysophosphatidylcholine. Can also utilize lysophosphatidylglycerol (LPG) as substrate in vitro. Has neither activity towards lysophosphatidic acid (LPA) nor lysophosphatidylinositol (LPI). Lysophospholipid acyltransferases catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. The primary function of the Lands cycle is to provide a route for acyl remodeling to modify fatty acid (FA) composition of phospholipids derived from the Kennedy pathway. Is involved in PC acyl editing and phosphocholine headgroup exchange between PC and diacylglycerols. This processes control the majority of acyl fluxes through PC to provide polyunsaturated fatty acids for triacylglycerols synthesis in seeds. Involved with LPCAT1 in the direct incorporation of newly synthesized fatty acids exported form the chloroplast into PC through acyl editing.", "AFDB_id": "AF-Q9CAN8-F1-model_v4" }, { "swissprot_id": "Q00650", "sequence": "MGILRKKKHERNASFKSVLTSILATQAATFLLLISGVSLAGTAAAFIATMPLFVVFSPILVPAGITTGLLTTGLAAAGGAGATAVTIILWLYKRATGKEPPAVLSKVLKKIIPGAAAAPRAAPAAAPAAAPAAAPAAAPAPKPAAAPAPKPAAPPAL", "function": "Many of the major pollen coat proteins are derived from endoproteolytic cleavage of oleosin-like proteins.", "AFDB_id": "AF-Q00650-F1-model_v4" }, { "swissprot_id": "Q06115", "sequence": "MCTAITYQSYNNYFGRNFDYEISYNEMVTITPRKYPLVFRKVENLDHHYAIIGITADVESYPLYYDAMNEKGLCIAGLNFAGYADYKKYDADKVNITPFELIPWLLGQFSSVREVKKNIQKLNLVNINFSEQLPLSPLHWLVADKQESIVIESVKEGLKIYDNPVGVLTNNPNFDYQLFNLNNYRALSNSTPQNSFSEKVDLDSYSRGMGGLGLPGDLSSMSRFVRAAFTKLNSLSMQTESGSVSQFFHILGSVEQQKGLCEVTDGKYEYTIYSSCCDMDKGVYYYRTYDNSQINSVSLNHEHLDTTELISYPLRSEAQYYAVN", "function": "Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of animals, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in the bile salts glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a preference for glycine-conjugated bile acids as substrates.", "AFDB_id": "AF-Q06115-F1-model_v4" }, { "swissprot_id": "Q9JHJ1", "sequence": "MAPLRVERAPGGSQLAVTSAQRPAALRLPPLLLLLLLLLLGAVSTSPESLNQSHPTEDSLLSKGKMEDYETNVLPCWYYYKTSMDSVKDWCNWTLISRYYSNLRYCLEYEADKFGLGFPNPLAESIILEAHLIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLVTLVVWRSKDGDAQA", "function": "Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.", "AFDB_id": "AF-Q9JHJ1-F1-model_v4" }, { "swissprot_id": "Q695T8", "sequence": "MVWTSAVVMASPHGSASRAGSNRRTDGLSVNLGQDNTLKHDTPTETAPSASPPRVAPAPIPPKGGPAATPGKDGALDNRGSHDSVPPVAVAIPGREEVNATASQKSVVAGANSQPTPGTQSSKAPASDVDGSSKHGSPEHPDAGSPEVNAEGVPVEEALQAIGDDDPLIHNLPDGVVGRRAPANPFNSSMYAKLRGKKKKHRPKVRDPKLNNNPLRGRLVVCISTTALLCWIYMWELIYNFTSFNGRCVSPVMYPDYKLQEAKQRQPYVIRYGYGGCEYNLGSLAYPRASFGTSAGDKGWPVDLVPNGSAGSAATSWDSPNARVLRHLGGLETNYIREYSETFRLFTSMYMHGGWLHILINLSCQIQILWIIEPDWGFLRTTLLFFLGGISGNLLSAVADPCSITVGSSGSMYALLGALIPYCVEYWKSIPRPGCILVFMIVVIIGILTGMAGFTDNYAHMGGALGGILWGFASITTVSACDKCTLGERMAMTPPFSWCVPKATQQKLLERAKARKAEAIRRRKLQAIQKKKAGGARGKAMYAVKMRLQEEGRPPCKMSFREWVIRGLCAAALFAYWLILFLYLLDPSLYKSYSPPGQLKFSGWLYCKCGTIVYQAPQTYGNLGRFWCFGSEKDAQYYLEP", "function": "Putative serine protease involved in intramembrane proteolysis and the subsequent release of polypeptides from their membrane anchors.", "AFDB_id": "AF-Q695T8-F1-model_v4" }, { "swissprot_id": "Q61578", "sequence": "MAPRCWHWWRWSAWSGLRPSPSRSTPTPGFCQKFSTQEKTPQICVVGSGPAGFYTAQHLLKHHTHAHVDIYEKQLVPFGLVRFGVAPDHPEVKNVINTFTQTARSDRCAFQGNVVVGRDVSVPELREAYHAVVLSYGAEDHQPLGIPGEELPGVVSARAFVGWYNGLPENQELAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDITEAALGALRQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTRPILDPSDFLGLQDRIKDVPRPRRRLTELLLRTATEKPGVEEAARQALASRAWGLRFFRSPQQVLPTPDGQRVAGIRLAVTSLEGVGESTRAVPTGDVEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGVIPNTEGRVVNVPGLYCSGWVKRGPTGVITTTMTDSFLTSQALLEDLKAGLLPSGPRPGYVAIQALLSNRGVRPVSFSDWEKLDAEEVSRGQGTGKPREKLVDRREMLRLLGH", "function": "Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.", "AFDB_id": "AF-Q61578-F1-model_v4" }, { "swissprot_id": "Q8BLD9", "sequence": "MLPPGRNGTAHRARLGLQRQLAQVDAPGGSAAPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVALAWTLSILISFIPVQLNWHRDKAGSQGREGLLSNETPWEEGWELDGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGACEPDPSLRASIKKETKVFKTLSVIMGVFVCCWLPFFILNCMVPFCSSGDAQGPRTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHLCFRTPVQTVNISNELISYNQDTVFHREIAAAYVHMIPNAVSSGDREVGEEEEAEEEGPFDHMSQISPTTPDGDLAAESVWELDCEEEVSLGKISPLTPNCFHKTA", "function": "Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.", "AFDB_id": "AF-Q8BLD9-F1-model_v4" }, { "swissprot_id": "Q66X01", "sequence": "MVDSSSYGLLQYFQKLSDEEFQRFKELLQKEQEKFKLKPLSWTKIKNTSKEDLVTQLYTHYPRQVWDMVLNLFLQVNRKDLSTMAQIERRDKQNKYKEFMKNLFQYIWTSETNTYMPDRSYNTIIDRQYKALLDIFDSESDPATAVVLGTRGKGKTVFLRKAMLDWASGVLLQNRFQYVFFFSVFSLNNTTELSLAELISSKLPECSETLDDILSNPKRILFVLDGFDYLKFDLELRTNLCNDWRKRLPTQNVLSSLLQKIMLPECSLLLELGESSCSKIIPLLQNPREIIMSGLSEQSIYFYCVSFFKIQLGVEVFKDLKKNEPLFTLCSNPSMLWMICSSLMWGHYSREEVISSSESTSAIHTIFIMSAFKSIFGLGSSKYKRFKLKTLCTLAVEGMWKQVYVFDSEDLRRNKISESDKTVWLKMKFLQIQGNNIMFYHSTLQWYFATLFYFLKQDKDTYHPVIGSLPQLLGEIYAHKQNQWTHAQTFFFGIATKHVITLLKPCFGNISFKTIRQEIIRYLKSLSQPECNEKLVHPKKLFFCLIENQEERFVSQVMNLFEEITVDISDSDDLGAAEYSLLRASKLKNLHLHIQKKVFSEIHDPEYGSLENFKLDQKFSAINWTMLSILFCNLHVLDLGSCHFNKKVIEVLCNSLSPTPNMPLTVFKLQRLLCSFMTNFGDGSLFCTFLQIPQLKYLNLYGTDLSNDVVEMLCSALKCSTCRVEELLLGKCDISSEACGIMATFLINSKVKHLSLVENPLKNKGVMFLCKMLKDPSCVLESLMLSYCCLTFIACGHLYEALLSNKHLSLLDLGSNFLEDIGVNLLCEALKYPNCTLKELWLPGCYLTSECCEEISAVLTCNKNLKTLKLGNNNIQDTGVKRLCEALCHPKCKVQCLGLDMCELSNDCCEDLALALITCNTLKSLNLDWNALHHSGLVMLCEALNHKKCKLNMLGLDKSSFSEESQTFLQAVEKKNNNLNVLHFPWVEDELKKRGVRLVWNSKN", "function": "May be involved in inflammation.", "AFDB_id": "AF-Q66X01-F1-model_v4" }, { "swissprot_id": "Q99JV5", "sequence": "MADPESPWSQIGRKIKLEGLSDVASISTKLQNTLIQYHSIKEDEWRVAKKVKDVTVWRKPSEEFNGYLYKAQGVMDDVVNNVIDHIRPGPWRLDWDRLMTSLDVLEHFEENCCVMRYTTAGQLLNIISPREFVDFSYTVGYEEGLLSCGVSVEWSETRPEFVRGYNHPCGWFCVPLKDSPSQSLLTGYIQTDLRGMIPQSAVDTAMASTLANFYSDLRKGLRKA", "function": "Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.", "AFDB_id": "AF-Q99JV5-F1-model_v4" }, { "swissprot_id": "Q9SJ45", "sequence": "MKLPFLNKNHSTSSYSSNSSSSSWPWPSCNQNPKTLSFRATITFTNPIHDQDDDELDLLDPPEITDSVENVIKGLRSSERLIFESKGETNSILEEATSKREEEDEEEGFMLFSLESDDPYSDFKRSMEEMVEAHALHHDWKSLEKLLLQFLKVNAKTSHRYIFAAFVDLLMNLALDTKKAIINNDISKDDGVSASRAAAAGEASTSCCNSMTLGESPSSPLSFYTSCSSSSSSDETSSMSVRFLPLSSLLEMDEKTKEILV", "function": "Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.", "AFDB_id": "AF-Q9SJ45-F1-model_v4" }, { "swissprot_id": "Q9V579", "sequence": "MVVAASTCRTETVFDYSWMNVVVAYWNRYPNPSSTHVLTEDTIQREVRDGKLFSRRLLSKTNPVPKWGARFYNNVPVKIVEDSVLDPVKKTFTTFTRNLGMTKIMKVDEIVVYSEQKDGSTLAVRRAYISSQVFGFSRAIRAFGIERFKANGNKASNGFNYVLRRMFPDSLVGGGHHQHAVTTTSPAGELPATTITVSTTNGSLNNQGALKSAAKVGYEFFKSHASKIAQLFSVKN", "function": "Involved in maintaining the structural and functional integrity of mitochondria. Activity is required for maintaining the subcellular distribution, shape and activity of mitochondria in neurons and as a consequence has an important role in the development and maintenance of dendritic arbors. Function may be particularly important in class IV dendritic arborization (da) neurons.", "AFDB_id": "AF-Q9V579-F1-model_v4" }, { "swissprot_id": "Q2GSS4", "sequence": "MTLKEEFATRNFSIYGQWLGILSMILCFALGIANLFTFRVLIIILSAVCLASSFVILFIEVPLLLRICPTSSKFDDAIRKITTNYMRAAAYAVMAVVQWLTLLSAATSLLAAAVFLSFTCICYLLAGHQGPGLCRQQDPGRRRRRADDCMSGRARLPWA", "function": "Golgi membrane protein involved in vesicular trafficking.", "AFDB_id": "AF-Q2GSS4-F1-model_v4" }, { "swissprot_id": "Q6DBN1", "sequence": "MRCISCREEYLPRNAGTCKECYVEAGETEEELKREIDDLKAKVAFLRLSSSLDHGTSSTSRSFTDVVLIASEDNAGSPPIPAHKSVLVSRSPVFKAMLENEMEESLSGTIKISDVSYDALRTFVYYLYTAEACLDEQMACDLLVMSEKYQVKHLKSYCERFLVTKLSPDNSLMTYAFAHQHNAKHVLDAALSQIVENMDKLTKREEYMELVEKDPRLIVEIYEAYLSKQVNTAAGGTSTSKTS", "function": "May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q6DBN1-F1-model_v4" }, { "swissprot_id": "O05255", "sequence": "MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGLMIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGVAINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSILAIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGGVYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPLFKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR", "function": "Part of an ABC transporter complex involved in the uptake of guanosine. Responsible for the translocation of the substrate across the membrane (Probable). May be a nucleoside transporter of broad specificity but with various affinities for different substrates.", "AFDB_id": "AF-O05255-F1-model_v4" }, { "swissprot_id": "Q6JWV8", "sequence": "MNSGDSSLIDAVIYNHTLCDGWTNSTEGAIYHLGNTILFLGYMGGSGAYGALYIFSFLAPAFLCLALWGWLTMCGLDVFIWNLLLMLQCLAQVCHLIFRLMRDGLANEEFSALYTAVYLPLDVPVQVFKEITGAGENKVLSLAAEETYAVEGKTPIDQLSFLLSGRIRVSLEGQFLHYIFPHQFLDSPEWESLRPAEEGNFQVTLTAETDCRYISWRRRRLYLLLSKDRYIARLFSVMLGSDIADKLYSLNDKLFAKSGVRLDIRLPSLYHVLAPSPPGSEGGSASSPPRGSLGDPTVIKVDPAPSNPGSGTRNPQPDQGKNPVPKNPHQHWSSDTEMPSGEDSTSLILEDFADMTGSLMDYGHEREYLK", "function": "Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding.", "AFDB_id": "AF-Q6JWV8-F1-model_v4" }, { "swissprot_id": "Q87K03", "sequence": "MLKTDLIFERENFSHHDFQNATFKNCHFYMCSFDHADLRDAKFIDCRFIESKALEGCSFRFANLKDASFTNCMLAMSLFNGANCMGLELRKCDLKGANFQGANFANRVSNTMFFCSAFITGCNLTYCNFERVLLEKCDLFENRWNGANLAGATLKGSDLSRCEFSPEQWGTFNVEQCDLTHVELDGLDIRRVSLFGVKICDWQQEQLLAPFGLIIL", "function": "Has no effect when overexpressed in E.coli. When Cys-115 is mutated to Tyr and overexpressed it increases (fluoro)quinolone resistance in E.coli up to 16-fold for ciprofloxacin, levofloxacin and nalidixic acid.", "AFDB_id": "AF-Q87K03-F1-model_v4" }, { "swissprot_id": "A6L3K9", "sequence": "MILKRISILNYKNLEQAELEFSPKMNCFIGQNGMGKTNLLDAVYYLSFCKSATNPIDSQNIRHEGEFFVIQGFYETDQGEPEEVYCGLKRRQKKQFKRNKKEYNRLSDHIGFIPLVMVSPADAELIAGGSDGRRRFMDVVISQYDKEYLDALIRYNKALTQRNALLKSEQEFDEELMLVWEEMMASAGEVVFKKRSEFIAEFIPTFQSFYSYISQDKEKVNLAYESHAMSGGLLDIIKESRRRDRVMGYSLKGVHKDDLIMQLGDFPIKREGSQGQNKTYLIALKLAQFDFLKKTGGNTTPLLLLDDIFDKLDAFRVEQIVKLVAGDRFGQIFITDTNRDHLDKILKKIEREYKVFAVEDGEVTERKEMAE", "function": "The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.", "AFDB_id": "AF-A6L3K9-F1-model_v4" }, { "swissprot_id": "O87691", "sequence": "MILLLAGTSDARALAVQVKKAGYDVTATVVTDNAAIELQRAEVKVKIGRLTKEDMTDFINEHGVKAIVDASHPFAEEASKNAIGAAAETAIPYIRYERASQAFTYDNMTMVSTYEEAAEVAAEKKGVIMLTTGSKTLQVFTEKLLPLSDVRLVARMLPRLDNMEKCQQLGLPQKNIIAIQGPFTKEFDRALYKQYGVTVMVTKESGKVGSVDKKVEAAKELGLDIIMIGRPKIEYGTVYSTFEEVVHALVNQTRS", "function": "Catalyzes the reduction of the macrocycle of cobalt-precorrin-6A to cobalt-precorrin-6B.", "AFDB_id": "AF-O87691-F1-model_v4" }, { "swissprot_id": "G5E8A8", "sequence": "MEFLGTTQTASFCGPKKGCGLQALPPAGQEPVVQECYQPFHLPGYRYLNAWRPSVFHKIATSQTIPEECSGIRRPPTILPSLRSALFCRYTPRDWDRSNDLQIRNAEASRLWASRLTGDSLRIMQDKDQLIHQMQEGTSRNLGQRLSDLGFWKSELCYELDRLLTENSSMDTLKRRLECAAEEVNCPLQVALECLYNREKRIGIDLVHDNVEKNLIREVDLLKCCQDQMRKLAKRIDFQIRDNRDAQHSLERDIEDKSSAQYIDENCFNLRSTSDSISFFHGVEKFDGTVSIPETWAKFSNDNIRHAQNMRANSIRLREEAEHLFETLSDQMWKQFTNTNLAFNARISEETDVKNKLQTQLAKILQEIFQAENTIMLLERAIVAKEYPLKMAQTMLACRTRRPNVELCRDVPQFRLVNEVFTIDDTLQTLKLRLRETQDTLQLLVMTKSRLEHELAIKANTLCIDKDKCMSMRKSFPSTPRLTGYTCSAIGSGPYANHAPRISSGPCSGSALCKGPASCGGGASCGGGASCGGHAPCGSALCSHSVSRSGPGFAPVC", "function": "May be a structural component of the sperm flagellum.", "AFDB_id": "AF-G5E8A8-F1-model_v4" }, { "swissprot_id": "Q4JB16", "sequence": "MTIRLVIVEPEGAYNLGFIARLVKNFLIDEFYVVNPKCDINEAIKFSAKGSEVIEKMMKITNNFDDAIRDVDLKIATSSIADIKGDLLRKSIRPIDLERLIKDKKVAFIFGRESVGLTREEIAKSDFLLFIPANPEYPVLNLSHAVGIVLYELWRNRDNKVPTVSSEPIKLIDDYSKKITDILVNKEATKSMYLVLKRVLIKGIEDNEEAMTIVRILRKIYVRLAKKENESDKLL", "function": "Catalyzes the formation of 2'O-methylated cytidine (Cm32) at position 32 in tRNA. Is specific for cytidine.", "AFDB_id": "AF-Q4JB16-F1-model_v4" }, { "swissprot_id": "P86842", "sequence": "MGTIARYYAHVVLFLVATSVIFTVKKTEAGVPCAESCVWIPCTVTALLGCSCKDKVCYLNHVIAFEAKTMDEHHLLCQSHEDCYKKGSGNFCAPFFNHDVKYGWCFRAEFEGYLLKDFLKMQPRDILKISKAIAK", "function": "Probably participates in a plant defense mechanism.", "AFDB_id": "AF-P86842-F1-model_v4" }, { "swissprot_id": "B5YIX2", "sequence": "MRKLILISLCIFFLASCSELQEVRDIKNAGMPPKYYPEPPQTQVASEGSLWRNKASLYEDKKARRVNDLVTILINESTSAQKTASTTASRDSSTNYGLDTFFGMNTDFNIHNLPLINGFYKAGNVFSPSVKGSATSDFKGDGDTARTGKITGTITAKVVEVLPNGNLVIESRKEVIVNNEKEILVLRGIIRPDDISQSNTILSQYVADAQIYLVGEGTLGDKQSQGWLVRFLDKIWPF", "function": "Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.", "AFDB_id": "AF-B5YIX2-F1-model_v4" }, { "swissprot_id": "P69825", "sequence": "MRLSDYFPESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLTLLEQGVYFPGNDEPIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADIISRG", "function": "The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.", "AFDB_id": "AF-P69825-F1-model_v4" }, { "swissprot_id": "Q5ZM96", "sequence": "MRVKLCGAAGGRLGTLAGLGRSGAAALALPGCLLYTRTGTAPHLTLDTLREVSGVPPVAQLTLPAMAELHDVLAEYKEGAAKFIGMPDTVLYCSLQDPVAPCPSGYNTNKTVSLWSSSGRMEMTASKFMDIQRAIQPDWFQCIADGDTISGEVTRKRAKKSVDRSLSFLDACLQLLEKTPELQGSVMFGTIEGGDVLEERLRSARETAKRPVGGFLLDGFQGRAMAKETKMNLISSVTAELPEDKPRIIHGVGKPDEVLECIERGVDIFESFFPFQVTERGCALVFGYDYLSDPKAEAALKQNGAQDLEKNSPEEDQEEEVVKADPEMTPFEIFLKEKRYHDDFRPLLEGCTCYCCQRHTRAYLHHLLVSSELLAGVLLMMHNFQHYFSFFSAIRDALRDDKLDQLKKLIFRQALQGPENAKIDQ", "function": "Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).", "AFDB_id": "AF-Q5ZM96-F1-model_v4" }, { "swissprot_id": "Q59606", "sequence": "MLSKQISNLNSSSNKPKILSLFSGCGGLDLGFHQAGCETVWANDFSHWACESFRKNIGDVIVEGDIEQINPNDPTIPDCDIILGGFPCQDFSMIWKQPGLEGERGNLYKSFLRFVNAKKPKVFVAENVKGLLTANKKKAIQQIITDFENCGYYVQANVYNFAEFGVPQFRERVLIVGVRLDTGFDFRHPEPTHNETGENGLKPYVTAGQAISNIPQNASNNELLKISDKTRRMLELIPEGGNFTDIPKDHPLYVKGMISHVYRRMHRNEPSKTIIAAGGGGTWGYHFPEPRAFTNRERARLQSFPDDFEFVGSTTEVRRQIGNAVPPQGVVELAKSILPIFSDNYEKVDLHEKLVEEKEILFHDRLSKIRGGKQ", "function": "A methylase, recognizes the double-stranded sequence 5'-GCSGC-3', methylates C-5 on both strands, and protects the DNA from cleavage by the NgoFVII endonuclease.", "AFDB_id": "AF-Q59606-F1-model_v4" }, { "swissprot_id": "P32644", "sequence": "MDFQCRTCSQAYDAEQMMKHLSSTRHKTVFDTSNDEDICCEECQDKNIHQLQIIRFGGEDMVLLCNSCFRKEYSETERPSTSYSLQNGSILKFWEKYVKVRECCCDECGEESNLNANRNGEVLCDKCLPKSNRAKDFVSEKSGRFLYIYLGLNETQNSTRKPRKKGGRRVGRGKKGRKGAKIKKEKKETFEAKISRIAYEVKKENSTIQSSSSSNLRNFKGFKAVESDPVVAAKVSKSETSRSNPGPSNRNKGKGNKANHKKNSGNGIGKEKERKTNIRNNVRNSQPIPEDRKNTNSHVTTNSGGKGKNESVDKHQLPQPKALNGNGSGSTNTTGLKKGKKDHAGQKTKGNDKTGNKNPREAKLNSAGRKNALGKKSNNQPNKGTSRWTIGSDTESSREPSISPNENTTSITKSRNRNKKASKPTLNEKSKTTTMPKKLETKNQEKNNGKTKDGKLIYEEGEPLTRYNTFKSTLSYPDLNTYLNDYSFALFLEQKLENEFVQNFNILWPRNEKDTAFIINVEKNNNSELEKLLPANLLALGRPAFNERQPFFFCTQDEQKVWYIFIKELSIQRGKYVLLVELFSWNNLSLPTKNGSSQFKLLPTSAQTSRILFAMTRITNPKFIDLLLGQKPIKEIYFDNRLKFSSDKLNRSQKTAVEHVLNNSITILQGPPGTGKTSTIEEIIIQVIERFHAFPILCVAASNIAIDNIAEKIMENRPQIKILRILSKKKEQQYSDDHPLGEICLHNIVYKNLSPDMQVVANKTRRGEMISKSEDTKFYKEKNRVTNKVVSQSQIIFTTNIAAGGRELKVIKECPVVIMDEATQSSEASTLVPLSLPGIRNFVFVGDEKQLSSFSNIPQLETSLFERVLSNGTYKNPLMLDTQYRMHPKISEFPIKKIYNGELKDGVTDEQKAWPGVQHPLFFYQCDLGPESRVRSTQRDIVGFTYENKHECVEIVKIIQILMLDKKVPLEEIGVITPYSAQRDLLSDILTKNVVINPKQISMQQEYDEIELFNAAGSQGTAGSLQNNVINIINGLHVATVDSFQGHEKSFIIFSCVRNNTENKIGFLRDKRRLNVALTRAKHGLIVVGNKNVLRKGDPLWKDYITYLEEQEVIFTDLTAY", "function": "Probable RNA helicase, which may be involved in modulation of the translation termination process. Probably unwinds double-stranded RNA. In vitro, unwinds covalently closed, circular DNA in the presence of a DNA topoisomerase TOP1 and replication factor-A protein RFA1.", "AFDB_id": "AF-P32644-F1-model_v4" }, { "swissprot_id": "Q57092", "sequence": "MKLKTGLNLTALLLFMISVAFPAQADTQKMYGIRGDNLSIATQMPAPRTYSVKGQTYTTKSGNEAKSYIKEGLASYYHLKFDGRKTASGDVYNSKQFTAAHKTLPINSYALVTNLHNNRKVIVRINDRGPFSDKRLIDLSHAAAKEIGLISRGIGQVRIEALHVAKNGNLSGAATKTLAKQAKTQEAADRLVLKSNTLFDNTSKSINALKGTEFYCLKMLELTSRSQANKLITQLALANIQTEVNRSGNKYEIYIGPFDDKTKMAQVRTKLQKMANNKPLIVYTYKN", "function": "Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.", "AFDB_id": "AF-Q57092-F1-model_v4" }, { "swissprot_id": "P21268", "sequence": "MKTPTRVSFEKKIHTPPSGDRDAERSPPKKFLRGLSGKVFRKTPEFKKQQMPTFGYIEESQFTPNLGLMMSKRGNIPKPLNLSKPISPPPSLKKTAGSVASGFSKTGQLSALQSPVNITSSNKYNIKATNLTTSLLRESISDSTTMCDTLSDINLTVMDEDYRIDGDSYYEEDSPTFMISLERNIKKCNSQFSPKRYIGEKCLICEESISSTFTGEKVVESTCSHTSHYNCYLMLFETLYFQGKFPECKICGEVSKPKDKDIVPEMVSKLLTGAGAHDDGPSSNMQQQWIDLKTARSFTGEFPQFTPQEQLIRTADISCDGFRTPRLSNSNQFEAVSYLDSPFLNSPFVNKMATTDPFDLSDDEKLDCDDEIDESAAEVWFSKTGGEHVMVSVKFQEMRTSDDLGVLQDVNHVDHEELEEREKEWKKKIDQYIETNVDKDSEFGSLILFDKLMYSDDGEQWVDNNLVILFSKFLVLFDFEEMKILGKIPRDQFYQVIKFNEDVLLCSLKSTNIPEIYLRFNENCEKWLLPKWKYCLENSSLETLPLSEIVSTVKELSHVNIIGALGAPPDVISAQSHDSRLPWKRLHSDTPLKLIVCLNLSHADGELYRKRVLKSVHQILDGLNTDDLLGIVVVGRDGSGVVGPFGTFIGMINKNWDGWTTFLDNLEVVNPNVFRDEKQQYKVTLQTCERLASTSAYVDTDDHIATGYAKQILVLNGSDVVDIEHDQKLKKAFDQLSYHWRYEISQRRMTPLNASIKQFLEELHTKRYLDVTLRLPQATFEQVYLGDMAAGEQKTRLIMDEHPHSSLIEIEYFDLVKQQRIHQTLEVPNL", "function": "Inhibitor of the cyclin-dependent kinase CDC28. Necessary for cell cycle arrest. Involved in pheromone response. Contributes to mating efficiency. Required for oriented polarization of yeast cells in response to mating pheromones.", "AFDB_id": "AF-P21268-F1-model_v4" }, { "swissprot_id": "Q9P7C2", "sequence": "MMKLENKLHRVLCSLHQNSISTHKTYVAVAAQDEYVRMGKVSLPRMYAVKPRIQKNFQDNYRFYGTLLCICWLYFFIWYPFALLALMVGVFLSFVMHGLGSLTINQNIRLDPKYSIPGVCAVTLIVIMFLAPVGRLFWSFCIVSSFAGLHCLLTTYENPAGIL", "function": "Has a role in meiosis.", "AFDB_id": "AF-Q9P7C2-F1-model_v4" }, { "swissprot_id": "O31989", "sequence": "MEYVVMIIILLALFFIFTVFLNTRYSFDEKCLVLKFGLSKTEIPINQIVSIKESDKYGVADNIDYKIGMPYAQPDRIVIETTNKRFLVFLNGAQQFIQKYKRVSV", "function": "Is essential and sufficient to confer resistance to the bacteriocin sublancin 168.", "AFDB_id": "AF-O31989-F1-model_v4" }, { "swissprot_id": "Q28FE5", "sequence": "MAQHDFAPAWLNFPTPPSSTKPFLYSDKHSEGLGRSDCAFNVNRQRHSSSDAFDSAIGRPHGGNLAKREKIAWRPQSRAGAEPTWQRDTSPHPYSMKSQLHSENNTSEIDLPRKVDREERKMFEVEDFSSLYPEHERGKNSFAAGLWEYPVSDRSRSSQMLGIKKGVKDDFSLSGYSIAAGNQSLPGKHWAGIKKEECKSLTKESSIGSSFYQDCPHEKYRPNTSLHAELLAVTPCSLEGEEDTNLNNRNGSCPERDINLNFDENKISEDNGNTLMSGQISSAYPPDGVLSSSLEAEFRLLREMGWQEDSENDETCAPLTEDEMKEFQAISEQLQKNGLRKHVFLRNALALDLFHDSVQKEDSETSSSSDTSDDE", "function": "Functions as a GC-rich promoter-specific transactivating transcription factor.", "AFDB_id": "AF-Q28FE5-F1-model_v4" }, { "swissprot_id": "P28586", "sequence": "TSLCASKQRYLVINLQLGLFLTVKEPSGYSEATLESFNSGTNQLFCLIPEGNRYFIAFDNDDYDTVLDVEFAQDVAGARVIAYTKKASNDDNQLWGLVPLPETPGIIATALPSSNVITGTGIGESMEMQPEDPDLNQVFGFLKY", "function": "Possesses D-galactose binding specificity.", "AFDB_id": "AF-P28586-F1-model_v4" }, { "swissprot_id": "P17894", "sequence": "MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISLLVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSGKSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALKTYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQQISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYYLLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEIDQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKSTFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGELSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLPQVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELLKQADQVKTTG", "function": "Involved in recombinational repair of damaged DNA. Seems to be the first protein recruited to repair centers, foci that are the site of double-strand DNA break(s), followed by RecO and then RecF.", "AFDB_id": "AF-P17894-F1-model_v4" }, { "swissprot_id": "Q8K558", "sequence": "MDCYLLLLLLLLGLAGQGSADSHPEVLQAPVGSSILVQCHYRLQDVRALKVWCQFLQEGCHPLVTSAVDRRAPGNGRIFLTDLGGGLLQVEMVTLQEEDTGEYGCVVEGAAGPQTLHRVSLLVLPPVPGPREGEEAEDEKETYRIGTGSLLEDPSLDPSASAGPHEFRRRENSIPLIWGAVLLLALVVVAVVIFAVMARKKGNRLVVCGPSQSTGVPGMDPPSAAHRSSDSGLPSDIPHVRLDSPPSFDSIYTGSSLDPPSSEPPAPPSQPPLPPKVLMSSKSVTYATVVFPGGDKGKIASCEPVQDPPNSQTPPSK", "function": "Cell surface receptor that may play a role in the innate and adaptive immune response.", "AFDB_id": "AF-Q8K558-F1-model_v4" }, { "swissprot_id": "Q6MGM8", "sequence": "MNMKLTIVTPEKRILVGQEVDEVTVPAFKGELNILPGHAPLITTLETGVMKWKLKGKEKQDLAVISWGYCQVSPEGVNILANIADLPEEIDLQATKEFLALSEKKIMNELITDEDWAEFQRDWAHARAKIEAAEQQPAKK", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-Q6MGM8-F1-model_v4" }, { "swissprot_id": "F4JI44", "sequence": "MVRLLQPKHMVQAVNALHWRNSVEFHKLLKDNGDFSICFNSEQVLPQKISVEKMVKMLPRHLIAVVMTPNKDGKSRYILCGIRLLQTLCDLTPRNAKLEQVLLDDVKLSAQMIDLVILVIIALGRNRKESCNSNKESLLEATLVASCLHLFHGFISPNSQDLVLVLLAHPRVDVFIDSAFGAVLNVVISLKAKLLYRQTDSPKKLGASSVEEVNFHCQQAEAALQFLHSLCQHKPFRERVAKNKELCGKGGVLRLAQSILSLTITPEFVGATVTIASTSRMKAKVLSILQHLFEAESVSFLDEVANAGNLHLAKTVASEVLKLLRLGLSKASMATASPDYPMGFVLLNAMRLADVLTDDSNFRSFFTEHFSMVLSAVFCLSHGDFLSMLCSSDLSSREDDANVDYDLFKSAGWILSVFSSSGQSVTPQFKLSLQNNLTMSSYAHQRTSLFIKMIANLHCFVPNVCQEQDRNRFIQNVMSGLRKDPSSILIKMLPGSSYTPVAQRGTGVCRNLGSLLRHAESLIPSSLNEEDFLLLRVFCDQLQPLIHSEFEESQVQVKVKKLFALLYIGFTILWLICLVTLIQDIEGRGGNLSGKLKELLNLNNEEASEDCDVRVEGVMTKQGVNEEIDTVERLKESDADASNLETSGSDTSSNRGKGLVEEGELVQNMSKRFKGSASGEVKEDEKSETFLVFEKQKKKRKRSIMNADQMGMIEKALAEEPDLQRNSASRQLWADKISQKGSEVITSSQLKNWLNNRKAKLARANKQTGPAHDNNSSGDLPESPGDENTWQQKPSTPIKDQTVTETPKTGENLMRTSSSSEEGIKQGQQVRLMDERGDEIGKGTVLRTDGEWNGLSLETRQICVVDVMELSESYDGSKKMIPYGSDDVGRTFTEANSRFGVMRVAWDVNKLQY", "function": "Regulates COOLAIR, a set of antisense transcripts originating from the 3' end of FLOWERING LOCUS C (FLC). Associates with single-stranded DNA that is part of an RNA-DNA hybrid, or R-loop, that covers the COOLAIR promoter. R-loop stabilization mediated by NDX inhibits COOLAIR transcription, which in turn modifies FLC expression.", "AFDB_id": "AF-F4JI44-F1-model_v4" }, { "swissprot_id": "P40956", "sequence": "MRFRSSSHSLKHVDRELKELINSSENANKCGECGNFYPTWCSVNLGVFLCGRCASVHRKVFGSRDDDAFSNVKSLSMDRWTREDIDELVSLGGNKGNARFWNPKNVPFPFDGDDDKAIVEHYIRDKYILGKFRYDEIKPEDFGSRMDDFDGESDRFDERNRSRSRSRSHSFYKGGHNRSDYGGSRDSFQSSGSRYSRQLAELKDMGFGDTNKNLDALSSAHGNINRAIDYLEKSSSSRNSVSAAATTSTPPLPRRRATTSGPQPAIFDGTNVITPDFTSNSASFVQAKPAVFDGTLQQYYDPATGMIYVDQQQYAMAMQQQQQQQQQLAVAQAQAQAQAQAQAQVQAQAQAQAQAQAQAQQIQMQQLQMQQQQQAPLSFQQMSQGGNLPQGYFYTQ", "function": "Appears to modulate the timing of budding to obtain an appropriate cell size independent of the DNA replication cycle. Transcription factor involved in both heat resistance and flocculation.", "AFDB_id": "AF-P40956-F1-model_v4" }, { "swissprot_id": "Q753D4", "sequence": "MNEKEELHLYHVSLQKQRNYVHSCIGHFVDYRHHHIRAQGGSVEGGKKGSKWRKQLQICMATQTQVELYDVEEGRLRRLFTRTVFGTITGLSSVVADGRSVLIVVGDSGKMSVLRFKYEGGRVRLEALFNEPLSRSGVRRLSPQAHVSVDPQGRCVLLSAMERNKVCYLMDVKQGELQVSSPLEANRPNYVTMQTAACDVAFDNPIFASLEIDLADGAKYLFFYMLDLGLNHMAKVADFELGDGSANFIMSVPDLEQYGINTKAGGPDDGDPDAIVPFVLMGFDNYVSLKDLRGRYDINVQIPTRKLSQKTIITAGTVQKLKRDFFMLLQSNHGDLYKVKILPDEKTASPVVTISYFDTIPQAQNLHIFKHGYMFANSEYGNSYLYQFENLDDEEESMLTSVMPGRRLIIEPRTVLKNLLVADKLALVNPILSSQLTERVPLTIATSTLGDVRLFTAGVNFMDIISSPLPAAPLDIWTVATNGSRFHKLLFIALQESTMILKIAAGTVEELELPHNPFVIAQDKTVLIAHMGGQSIIQVTENKMVHIIENRDESYESKLEWFPPAGICILKASSNSTQLILALSNNEVVYFEIGSNESLNELQDRIEVEERITALAIGNGNRSDYMIIASVDSTVKVYSLKVQDQANFLEVVSMQVLVSPASSLQLASSGGSLCLHIGLDSGVYVRSKLDRNTGELFDVRTKYLGTKPVEISLLLDMNPYINEEVDDEGEEEEEQDDEESLGGPHSRLVPCVVLHSGKTWISYELDSSLFIRPLLNDQSLKRVAQFTSNEIQRNGCCSISSAGFLVIGRIGTFRNNDCWFQESSLALPDSEDSVNGNELENDEKDPDALLEEKQKVNSSIGKLIIPDPDDIKLFYYCEYNEVENSCRVSLFKQGISYKHENSTEAFQLIPDCRPSTATIARFGLDMKHLVISTVNGVLKTFVIRITKAANNRRFELLALHDTVAGSTIHAMCPFHDKLLVPLANAVVLYGLGKKQLLKKSISYLPTSITKIVALDQWNGTRVAVGDIHESVTLLHFDERKNQFIPVADDVTKRHVTVVKFVDECTVIGGDRFGNIWLLRLPLEYDRLIKEGVDSYLLTLNTGIPSNIRECVFKWQLLNHFYINDIPMSFHLIASPQMADRASILYAGLQGTIGYLIPLITRREIEFFDLLEQAMRDADHLFYLDQENRLNDTSELNDGADEEGSVIDRRFPSVQKKRKIPEGAYSLVGRDAMMYRSYYNPVRHVTDGDLCEQFLELYPSEKNFLAARVDNRSVQEIERRINDMRTNCM", "function": "Involved in pre-mRNA splicing and cell cycle control.", "AFDB_id": "AF-Q753D4-F1-model_v4" }, { "swissprot_id": "Q0P9D1", "sequence": "MARTEKIYIYGASGHGLVCEDVAKNMGYKECIFLDDFKGMKFESTLPKYDFFIAIGNNEIRKKIYQKISENGFKIVNLIHKSALISPSAIVEENAGILIMPYVVINAKAKIEKGVILNTSSVIEHECVIGEFSHVSVGAKCAGNVKIGKNCFLGINSCVLPNLSLADDSILGGGATLVKNQDEKGVFVGVPAKRM", "function": "Acetyltransferase that modifies the UDP-4-amino-sugar to form UDP-N,N'-diacetylbacillosamine in the N-linked protein glycosylation pathway.", "AFDB_id": "AF-Q0P9D1-F1-model_v4" }, { "swissprot_id": "Q5XJ97", "sequence": "MADDAAVEDYPTEIEDNLNDFDSSLSSVQNMVQTLVSVSRSDRLLKLDPLEQAKLDLMSAYALNSMFWMYLVTQGVNPKDHPIKQELERIRTYMNKVKEITDRRKAAHIDKEAASRFVRNALWDADDKKRKDKTEHQQKGKHTKFTWS", "function": "Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.", "AFDB_id": "AF-Q5XJ97-F1-model_v4" }, { "swissprot_id": "Q9CDA8", "sequence": "MPHDGHEPPQRIIRLIAVGAGITGLLLCAVVPLLPVKQTTATIRWPQSATRDGWVTQITAPLVSGTPRALDISIPCSAMATLPDSVGLVVSTLPSGGVDTGKSGLFVRANKNAVVVAFRDSVAAVAPRPAVAAGNCSVLHIWANTRGAGANFVGIPGAAGILTAEKKPQVGGIFTDLKVPVQPGLSAHIDIDTRFITAPTAIKKIAVGVGAAAVLIAILALSALDRRNRNGHRLINWRVSMAWLAQWRVILATPPRAGGASRIADGGVLATLLLWHIIGATSSDDGYNLTVARVSSEAGYLANYYRYFGATEAPFDWYFTVLAKLASVSTAGVWMRIPATLAGIACWLIINHWVLRRLGPGTGGLSTNRVAVLTAGAMFLAAWLPFNNGLRPEPLIALGVLFTWVLVERAIALRRLASAATAAVVAILTATLAPQGLIAIAALLTGARAITQTIRRRRTTDGLLAPLLVLAASLSLITLVVFHSQTLATVGESARIKYKVGPTIACYQDFLRYYFLTVESNADGSMTRRFPVLVLLLCMFGVLVVLLRRSRVPGLASGPTWRLIGTTATSLLLLTFTPTKWAIQFGALAGLTGTFGAIAAFAFARISLHTRRNLTVYITALLFVLAWATAGINGWFGVSNYGVPWFDIQPVIAGHPVTSIFLTLSILTGLLAGGQHFRLDYAKHTEVKDTRRNRFLATTPLVVVATTMVLCEVGSLAKGAVARYPLYTTAKANLAALRSGLAPSVCAMADDVLTEPDPNAGMLQPVPGQIFGPTGPLGGMNPIGFKPEGVNDDLKSDPVVSKPGLVNSDASPNKPNVTFSDSAGTAGGKGPVGVNGSHVALPFGLDPDRTPVMGSYGENTLAASATSAWYQLPLHWKESIADRPLVVVSAAGAIWSYKEDGNFIYGQSLKLQWGVTRPDGIIQPLAQVMPIDIGPQPAWRNLRFPLTWAPPEANVARVVAYDPNLSPDQWLAFTPPRVPVLQTLQQLLGSQTPVLMDIATAANFPCQRPFSEHLGIAELPQYRILPDHKQTAASSNLWQSSEAGGPFLFLQALLRTSTISTYLRDDWYRDWGSVEQYYRLVPADQAPEAVVKQGMITVPGWIRRGPIRALP", "function": "Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.", "AFDB_id": "AF-Q9CDA8-F1-model_v4" }, { "swissprot_id": "Q55638", "sequence": "MLKTVAIQVQGRVQGVGFRPFVYTLAQEMGLNGWVNNSTQGATVVITADEKAIADFTERLTKTLPPPGLIEQLAVEQLPLESFTNFTIRPSSDGPKTASILPDLSTCSACLTELFDPSDRRYLYPFINCTHCGPRYTIIEALPYDRCRTTMARFRQCTDCEREYKQPGDRRFHAQPNACPRCGPQLAFWNRQGQVIAEANEALNFAVDNLKVGNIIAIKGLGGFHLCCDATDFEAVEKLRLRKHRPDKPLAVMYGNLGQIVEHYQPNNLEVELLQSAAAPIVLLNKKKQLILVENIAPGNPRVGVMLAYTPLHHLLLKKLKKPMVATSGNLAGEQICIDNIDALTRLQNIADGFLVHDRPIVCPVDDSVVQIVAGKPLFLRRARGYAPQPITLPKPTQKKLLAMGGHYKNTVAIAKQNQAYVSQHLGDLNSAPTYQNFEEAIAHLSQLYDFSPQEIVADLHPDYFSHQYAENQALPVTFVQHHYAHILAVMAEHGVMEESVLGIAWDGTGYGMDGTIWGGEFLKITQGTWQRIAHLQPFHLLGNQQAIKYPHRIALALLWPTFGDDFSADSLGNWLNFNNGFKNKINSRLNQDLNNKNLRQLWQRGQAPLTSSMGRLFDGIATLIGLINEVTFEGQAAIALEAQIMPNLTEEYYPLTLNNKEKKLAVDWRPLIKAITTEDRSKTNLIATKFHNSLVNLIITIAQQQGIEKVALGGGCFQNCYLLASTITALKKAGFSPLWPRELPPNDGAICMGQLLAKIQARQYIC", "function": "Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.", "AFDB_id": "AF-Q55638-F1-model_v4" }, { "swissprot_id": "Q8S8F8", "sequence": "MEPPKGDTVVKTEVPVKDPSLSVVDSKTKGVEDANTEIALSDEVEIETKGSDSTPVKAPSRTSSGSKKSVHWSPELVSGSQEPDQKAASSSSAGSNPYIARSPAETSDASLKDTMETVKGVLGRWGKRVAEAAKKTESLAGNTWQHLRTAPSFADAAMGRIAQSTKVFAEGGYEKIFRQTFETDPEEQLLNSFACYLSTSAGPVMGVLYISSAKLAYCSDNPLSYKNGDQTEWSYYKVVIPLHQLKAVNPSASIVNPAEKYIQVISVDNHEFWFMGFLNYDGAVTSLQDSLQAGALRSV", "function": "Involved in the spatial control of cell division, patterning and differentiation of Arabidopsis root epidermal cells. Could be part of a complex that negatively modulates GLABRA2 and CAPRICE expression via the maintenance of a repressor histone H3 epigenetics status of the GL2 and CPC promoters.", "AFDB_id": "AF-Q8S8F8-F1-model_v4" }, { "swissprot_id": "A7I145", "sequence": "MSETIVAVATAHGIGGISIVRLSGENALSLSDILINKNRKKNKTQNSVSSSQNRIQNFKKINLKPRYATLCELYDNDGNFMDESVVIYYKSPNSFTGEDIVEFQIHGGFTLENLIMDELITNGARIAMPGEFSKRAFLNDKMDLSKAEAIQSIILSRSKSAAKILARNLHGELKNFVIDLRKEIVKTMAFVETCIDYADDDLPNDILDKIQNLLSENITKIDEITQISASRRGLLEGFKVAIIGKPNVGKSSILNSLLKFSRAIVSDEAGTTRDRIEENLQIGSHLIRIIDTAGIRKSENSVENIGISYSIKAANEADIILAVFDASREFDKEDEKIFEILQNQKDKKIIKILNKIDLALKFKAGNSDNFLKISAKNDTKIITKVLNDYLNSQNFDGIMLSSNRQIMAFSNAGKALKRAQNLLNENSLELFAFELNIAIKEIASIYKPFERDEILESMFSNFCLGK", "function": "Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.", "AFDB_id": "AF-A7I145-F1-model_v4" }, { "swissprot_id": "A9B055", "sequence": "MPTTIQAISAEAINLPLTEPFAIASGAQAVAANVLVKVQLADGTLGLGEAAPFPAVSGETQTGTSAAIERLQSHLLGADVRGWRKLAAMLDHAEHEAAAARCGLEMAMLDALTRHYHMPLHVFFGGVSKQLETDMTITAGDEVHAAASAKAILARGIKSIKVKTAGVDVAYDLARLRAIHQAAPTAPLIVDGNCGYDVERALAFCAACKAESIPMVLFEQPLPREDWAGMAQVTAQSGFAVAADESARSAHDVLRIAREGTASVINIKLMKAGVAEGLKMIAIAQAAGLGLMIGGMVESILAMSFSANLAAGNGGFDFIDLDTPLFIAEHPFIGGFAQTGGTLQLADVAGHGVNLA", "function": "Has epimerase activity with a variety of hydrophobic dipeptides (in vitro). Enzyme activity is highest with L-Phe-L-Tyr, but is still relatively low, suggesting that L-Phe-L-Tyr is not the physiological substrate.", "AFDB_id": "AF-A9B055-F1-model_v4" }, { "swissprot_id": "Q01NF9", "sequence": "MTFAEELQQILPPDLPHRDAVIASAARHLDLIVETNQHFNLTRIVSPREAAIKHIADSVIPWRLFSGAPHVVDAGSGAGFPGIPLALVLPETRFTLLESTQKKARFIESAAADLGLANVEVRPDRAEDWLKTHRASIVTARAVAPLTRAVGLFAHALRAGARILLYKGPDAEAEIAEAASEAAKRRVHLRVVERYELPDSLGARTIVEIR", "function": "Specifically methylates the N7 position of a guanine in 16S rRNA.", "AFDB_id": "AF-Q01NF9-F1-model_v4" }, { "swissprot_id": "Q6C9E6", "sequence": "MIFRRQLSTLIPPKVASPATLHGAPNAKRMADVVSFYKALPQGAAPALPKTANPFKLYYRKYFHPKSGKASGAPLLHLILGIFLFGYISDYQFHLKHHKNGAH", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a/ATP6 in the membrane.", "AFDB_id": "AF-Q6C9E6-F1-model_v4" }, { "swissprot_id": "Q54TR1", "sequence": "MNKFILLLSLVTLSCVLAVPQLPAAQQYYMKGSFNIPYFNIVEPIELIYDSVNNRQYISVYNGMDITINFYNQDNTYNVGPVKYDMVCTTTPGNGSLVNVLPTEPSSWVYNGTSTVNGVQVFGYSQKITQYGRTGFYNFYVDANGVPVQFYMDGVDYVFGSHPDVYVLNFDIYTTDISSYESYFDIPVLCNNAKEAPAKENQFDGLFSSIGDNLLAKEEQASNLFKEYKAQYNKEYSSQDEHDERFINFKAARKIIATHNAKESSYKLGMNHYADLSNKEFNTLVKPKVARPSVTGADSVHDDESLRSIPSTVDWRNQNCVTPVKDQGICGSCWTFGSTGSLEGTNCVTNGELVSLSEQQLVDCAILTGSQGCGGGFASSAFQYVMEIGSLATESNYPYLMQNGLCRDRTVTPSGVSITGYVNVTSGSESALQNAIATTGPVAIAIDASVDDFRYYMSGVYNNPACKNGLDDLDHEVLAIGYGTYQGQDYFLVKNSWSTNWGMDGYVYMARNDNNLCGVSSQATYPIPTKN", "function": "Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity.", "AFDB_id": "AF-Q54TR1-F1-model_v4" }, { "swissprot_id": "Q21109", "sequence": "MCSVLIFISILTVLAQCQKIPRFDVSNSELLAMAQKLRQVDTNRARPDQIKLNYQGHTVTRDDSDAAQAKLFSKVDTSLFRKPSYELYINLMDNFNRQTGVIEPRVSQAEEKNEVGKFLDYVLESRPMQELYNWFKAKGHPIATSPQVFRFWIGQLWFSHYSRALGRPDTSGFEHVFIGEAKNGEISGMHNWVRFYVLENNRTENFDYKGFTVKRFNIMAALKFTWDGLLKRAGSILIGTSPEFDMALYTMCFLSRRGRETCDVEFDGCPLQITSFEIMQQNKVYIGSIYPTAGRITDQCRAQNRFN", "function": "Catalyzes RNA cleavage releasing a product with a 2',3'-cyclic phosphate at the 3'-end.", "AFDB_id": "AF-Q21109-F1-model_v4" }, { "swissprot_id": "A8ITV9", "sequence": "MAPKKKEDKDAPPPEDTNPYGVFVSVTMPSATVVLDVQDDAAAQRETHITLNIPGCHVPWASAHTAPSEGGVYQYSVVKHFRRSGGQDGLLQLINGVLTVTVNDSATNAVLASATVDQLQGFAIGQNTWSTEGLDLVPAAEVPEGVPKARSARLAFASIALQERPLPEGADAAALAAAPPPPEAELPPLLPYSYVSGEAAEKGNMVELVVSGLSPLPPNLQAAADAAGGKLHVTVGLALPGGGPAVAVSLAVAGGRVAAPAFRRELLPPGCLQALQYALEDGLPVVLEVARYVSAEGMADPAFEGYHAAAAAPALAAGLGAAGATEAAAEGLSLTAWAASGAKTCLPPYTAPAGKPKPVEAEVPPAGTCLWEKAGAQLAVSLRFARPVVPAWRPPPPPPRPLLELIPPRDLTPKPPPTTAVDEFKAKVRVIARALAEEYKAVLPPPDASVAAAAAGGGAEGRHKALIFELNRSGKYAQMRDSLKTAVVSLVREKYRKSGSMSPNEMALLYNDLYGSLLAAVHSSLNDLVDAAAARPRAPPPAPVPDKQRLGELLELAAQAEAMGDTDRAELLHQRRLLAKNDAQVWYEYGTYCLRRGGAKRGRAEECFREALALEPAHRGALLALLGCSVAAGRNTDPAYLESAEAAAHRLLDVAGRSSLDAWAALAVVYRAYGEAKRAELASCEQEMARLEKQQLAAAAAAASAGVSPSPSYGEGRAGGNGGGVPATEPSTASAGSVAGSAGELQARSFISLANTLLESLALPAEAALALELAAGLRHWPSVGPDTRTLHALAGALAEQALARAAGGGAASAAAEAMLTPGSSVLSMMRADAGEAVSSVAAEAAWRCRLLVAQLHKARGATDEAIRFYQSFIAITQQHAPSTPPPPPPPPPPPPPPPPQEYIEAARSSGRLAEVPLSAWLELAEAYAARGQARFAADVFLLGASARPGCAVLWRGAGRCFVGAEELGPADMALSEANVLDPEDPEAWGWLALVALREGRAEDAEKALAFGLRCGLGDPGLLLDIAAEYRAAGQRRAEQRVLQEVAVKLMPESCSARLLLARCLVAQRCGAEAAEAVAAARQLAAHEDDEAAVAELEAELRGMA", "function": "Axoneme-binding protein that acts as a regulatory componement of the outer dynein arm and regulates ciliary motility.", "AFDB_id": "AF-A8ITV9-F1-model_v4" }, { "swissprot_id": "Q2TB18", "sequence": "MGIRGLMSFVEDHSNEFFTDLKLRDTKIVIDGYALFHRLCFSSNLDLRYGGDYDSFADVVQKFFESLFACNICPYVVLDGGCDISDKKLTTLKDRAREKIQMAHSLSVGGSGYVCPLLIREVFIQVLIKLRVCFVQCFSEADRDIMTLANHWNCPVLSSDSDFCIFDLKTGFCPLNSFQWRNMNTIKGTQNYIPAKCFSLDAFCHHFSNMNKALLPLFAVLCGNDHVNLPIMETFLSKARLPLGATSSKGRRHHRILGLLNWLSHFANPTEALDNVLKYLPKKDRENVKELLCCSMEEYQQSQVKLQDFFQCGTYVCPDALNLGLPEWVLVALAKGQLSPFISDALVLRRTILPTQVENMQQPNAHRISQPIRQIIYGLLLNASPHLDKTSWNALPPQPLAFSEVERINKNIRTSIIDAVELAKDHSDLSRLTELSLRRRQMLLLETLKVKQTILEPIPTSLKLPIAVSCYWLQHTETKAKLHHLQSLLLTMLVGPLIAIINSPGKEELQEDGAKMLYAEFQRVKAQTRLGTRLDLDTAHIFCQWQSCLQMGMYLNQLLSTPLPEPDLTRLYSGSLVHGLCQQLLASTSVESLLSICPEAKQLYEYLFNATRSYAPAEIFLPKGRSNSKKKRQKKQNTSCSKNRGRTTAHTKCWYEGNNRFGLLMVENLEEHSEASNIE", "function": "Possible role in EGF receptor signaling.", "AFDB_id": "AF-Q2TB18-F1-model_v4" }, { "swissprot_id": "Q8S3F1", "sequence": "MDDSSFMDLMIDTDEYLIDDWESDFPICGETNTNPGSESGSGTGFELLAERPTKQMKTNNNMNSTSSSPSSSSSSGSRTSQVISFGSPDTKTNPVETSLNFSNQVSMDQKVGSKRKDCVNNGGRREPHLLKEHVLAERKRRQKLNERLIALSALLPGLKKTDKATVLEDAIKHLKQLQERVKKLEEERVVTKKMDQSIILVKRSQVYLDDDSSSYSSTCSAASPLSSSSDEVSIFKQTMPMIEARVSDRDLLIRVHCEKNKGCMIKILSSLEKFRLEVVNSFTLPFGNSTLVITILTKMDNKFSRPVEEVVKNIRVALAE", "function": "Transcription activator that regulates the expression of at least NAI2, PYK10 and PBP1. Required for and mediates the formation of endoplasmic reticulum bodies (ER bodies). Involved in the symbiotic interactions with the endophytes of the Sebacinaceae fungus family, such as Piriformospora indica and Sebacina.", "AFDB_id": "AF-Q8S3F1-F1-model_v4" }, { "swissprot_id": "Q9K266", "sequence": "MAVIYWDRSKIVWSFEPWSLRLTWYGVFFTVGIFLACLSARYLALSYYGLKDHLSFSKSQLRVALENFFIYSILFIVPGARLAYVIFYGWSFYLQHPEEIIQIWHGGLSSHGGVLGFLLWAAIFSWIYKKKISKLTFLFLTDLCGSVFGIAAFFIRLGNFWNQEIVGTPTSLPWGVVFSDPMQGVQGVPVHPVQLYEGISYLVVSGILYFLSYKRYLHLGKGYVTSIACISVAFIRFFAEYVKSHQGKVLAEDCLLTIGQILSIPLFLFGVALLIICSLKARRHRSHI", "function": "Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.", "AFDB_id": "AF-Q9K266-F1-model_v4" }, { "swissprot_id": "Q9LZ78", "sequence": "MDLDLIQDLPILNFPPAIKIRANTNRDDDGGGCTTPTSSDHKIPPTTATTPPPPPQKPRPPSTPSSLGIRSCKRKLMTSLSKYEIIVNKDEIERFFSSVYNQTMASSTTTAITVAKRRRSFRSCSRR", "function": "Cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle. Inhibits the kinase activity of CYCD3-1/CDKA-1, CYCD2-1/CDKA-1 and CYCB1-1/CDKB1-1 complexes in a dose dependent manner. Cooperates with SMR1 and SMR2 to promote endoreplication during leaf development. Required for normal trichome endoreplicating cell cycles. Positive regulator of effector-triggered immunity (ETI).", "AFDB_id": "AF-Q9LZ78-F1-model_v4" }, { "swissprot_id": "A0A2Z5U1Z1", "sequence": "MSDRTRTTRYANGSLRTCQNCARAKIRCIRSVPTGSCDRCERLRKTCQFQPGRRANAGPSLSESKDRRIDALEAKLDRLLAQSTSATVSEASIDDKSPTTTPTTPRPPPDVIDSGLLTLEAASLLLQDYQRTLMPYCPFVMVPSPATAATLRRDKPFLFLAILTAALYDNMPLQRTLELEVKRTIGRCMIFDGPVSFDMLQGLLVHLAWCQYHSRPRRFSQYLHLAISIITDLQLDRAPEDRFWRTRVDFNGELDREISWGREERRAVVGFFWFSSSISQILQKRSSFSFIPYLETSCELLASTAEYDSDQHLLQLIQLQRLSERIIVASGQHTSEPHDADALEQCYRDRRSELDLYLAQLPFPLTDSHLLMMQYHTVELYLCQVTLFDHKPSAQRPRHDSPFPIEALRMGLTAARTLLDFYISLPLRREVAFNNAGWVQLGFVVTLACKLAVAAADPHIHPHMADLTRALDLSTMLSRCILRIQALVTSQMDARGDRDVFYHYEKRLKRAQWWFESRSLSRSQQQRNEPLPVAGAGEASSPRNARIAEIPAEEEFQVGYAAVSGDGFDFQWPGLFPDPTFDDMFGDWMAQGSSGFDD", "function": "Transcription factor that, with himB, probably co-regulates the him gene cluster that mediates the biosynthesis of himeic acid A, a ubiquitin-activating enzyme (E1) inhibitor.", "AFDB_id": "AF-A0A2Z5U1Z1-F1-model_v4" }, { "swissprot_id": "Q9UIR0", "sequence": "MVDFPGYNLSGAVASFLFILLTMKQSEDFRVIGPAHPILAGVGEDALLTCQLLPKRTTMHVEVRWYRSEPSTPVFVHRDGVEVTEMQMEEYRGWVEWIENGIAKGNVALKIHNIQPSDNGQYWCHFQDGNYCGETSLLLKVAGLGSAPSIHMEGPGESGVQLVCTARGWFPEPQVYWEDIRGEKLLAVSEHRIQDKDGLFYAEATLVVRNASAESVSCLVHNPVLTEEKGSVISLPEKLQTELASLKVNGPSQPILVRVGEDIQLTCYLSPKANAQSMEVRWDRSHRYPAVHVYMDGDHVAGEQMAEYRGRTVLVSDAIDEGRLTLQILSARPSDDGQYRCLFEKDDVYQEASLDLKVVSLGSSPLITVEGQEDGEMQPMCSSDGWFPQPHVPWRDMEGKTIPSSSQALTQGSHGLFHVQTLLRVTNISAVDVTCSISIPFLGEEKIATFSLSGW", "function": "Negative regulator of T-cell proliferation.", "AFDB_id": "AF-Q9UIR0-F1-model_v4" }, { "swissprot_id": "Q4R585", "sequence": "MVWSWVAMASRWGPLVGLAPRCLWLLGAVLLMDASARPANHSSTRERAANREENEILPPDHLNGVKLEMDGHLNRGFHQEVFLGKDLGGFEEDVEPRRSRRKLMVIFSKVDVNTDRKISAKEMQRWIMEKTAEHFQEAMEESKTHFRAVDPDGDGHVSWDEYKVKFLASKGHSEKEVADAIRLNEELKVDEETQEVLENLKDRWYQADSPPADLLLTEEEFLSFLHPEHSRGMLRFMVKEIVRDLGEAGSSLAGAPGPGDQRQGPGIAGKSGKVLREPQPGCGLIRSRLTDQDGDKQLSLPEFVSLPVGTVENQQGQDIDDNWVKDRKKEFEELIDSNHDGIVTAEELESYMDPMNEYNALNEAKQMIAVADENQNHHLEPEEVLKYSEFFTGSKLVDYARSVHEEF", "function": "May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.", "AFDB_id": "AF-Q4R585-F1-model_v4" }, { "swissprot_id": "Q21625", "sequence": "MAYEFDLEDFNDNLEPFGFNCPAKDHFIEKLEGLCKTFRKSGEDIVDDVVSVMSNLGQKSVDSGILAKLEENLEAQAQKTVHTPRSVKKPARGRVPLAEKSGFILSGDPDDIEKPSHHLTNSAIAKLEGHFLDFSPFPGSPANEKFLKRADPSHVVTTIRGKKYQDKGLKGSTKSDDTIRIISKTPSTLYGGDKSSMVIEAKAQRMADIAHRIQKSFEEIVDWGNPSIPSVDVVYTYGQVIHDETKDNEKFGEHSVALMINDEDGTMIRMDFSKMTEDITLFPGQIIAVRGTNETGEELQVDKIFQPAALPVNPVETDTTKEIWFACGPYTATDNCGYEHLCELLDKVVAEKPDILMLAGPFVDKKNTFLNKPTFNITYDNLLEDLLLKVKETLVGTKTQVIIQPNASRDLCVPPVFPSAPFQQNRKLDKIKKELIFVADPCIFRISGVEVAMTSSEPIQALSNTEFHRSANQENIDRVARLSSHLLTQQCMYPLEPTEVPASMGDLLDVCCIGSTPHIVFAPTKLAPSAKCVNGSVFINSSTLAKGPTGNYAKMSINLNAGELMPGETVADYAQIQILKI", "function": "May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Required for the distribution of pie-1 in cell divsion.", "AFDB_id": "AF-Q21625-F1-model_v4" }, { "swissprot_id": "Q86XQ3", "sequence": "MSQHRHQRHSRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIYFSTLDYQDTTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK", "function": "Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.", "AFDB_id": "AF-Q86XQ3-F1-model_v4" }, { "swissprot_id": "F4KBF5", "sequence": "MFGVSMRTLISPSLAPFSLHLHKPSLFSTALRFSFSINNITPTNSPPSTISTRKLQTKATRVTSSSSSQPLSSSSPGEIHVVVGPMFSGKTTTLLRRILAERETGKRIAIIKSNKDTRYCTESIVTHDGEKYPCWSLPDLSSFKERFGFDDYENRLDVIGIDEAQFFGDLYEFCREAADKEGKTVIVAGLDGDFMRRRFGSVLDLIPIADTVTKLTSRCEVCGKRALFTMRKTEEKETELIGGAEVYMPVCRSHYVCGQNVLETARAVLDSSNNHSVVASSL", "function": "Part of the salvage pathway for purine and pyrimidine deoxyribonucleotide synthesis. Phosphorylates preferentially purines over pyrimidines.", "AFDB_id": "AF-F4KBF5-F1-model_v4" }, { "swissprot_id": "Q9I9N5", "sequence": "MDSIDTKRLNDSNASDRALSGCAVLFLGCSSLEHNFLSLYKDERGKFSVFKVIKLTLSDSVGGLEGYEILKLHDADPYLGVELKFMAMPPCQRFLESYACGSLTQFLSQHASRLLALPDGVEIETQLKAGVHTLDHSLQDIEICLDHIRQSQPVRLRDDEVTQLEQQLQNSYGPPSQPPQELPRNCFLFQKRVFDDRPLTPADQQRFAAHVGRDWKRVGRALQKNCRALKGPAIDNLAYEYEREGLYEQAYQLLGRFIQSEGRSAKLSRLISALEETKMTSMAEIMLGIQPRD", "function": "Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.", "AFDB_id": "AF-Q9I9N5-F1-model_v4" }, { "swissprot_id": "Q4J711", "sequence": "MNILNVVRRFEFQLFLVNVIIALFFYFENSAYFSSNNITTIFQYLAEIGIIAIGEAMLMLCGEIDLSPPALANFVPLITLTIYNSIYQAISPTPAIVVSILLSLGLASLIGLMNGLITTKAKVNSLITTVGTLFLFNGIALIYSGGYPESFPYFRFLGGTVSILPVPFIWSLGALVFLILLLHYTKIGVWTIAAGSNPTGASEVGVPVDRVKIINFIIMANIGALVGIIQGSRVLTIGATNFTADVVLEGIAAAVIGGTSLVGGKGSLVGAFLGSVFISELLNGFNILGINAYEFDAILGGAIVVVMVLSYYAKRASYKLKSIATATSSSPEGKDRITKILKFKIQKIYRRVEENE", "function": "Part of the ABC transporter complex XylFGH involved in the uptake of xylose and arabinose. Responsible for the translocation of the substrate across the membrane (Probable).", "AFDB_id": "AF-Q4J711-F1-model_v4" }, { "swissprot_id": "Q54QU8", "sequence": "MENFKNNELESSPIINKNNSSHSINNEDNNYYSHNLEHNDNNNNDNNNTITNSHINNHDHKHNHEHEHKHKHNHDHNHDHDHNHEEEYGHGNELEHNNDQEHNVGNKNLLTNNNNQSKKKKHGHSHGGGEDGSSSGGGGGRHGHGHSHGGGSGSDHNHGSSDEDDEESKPLNQLRNLDSKKKARYSLILALTLTTIFMVGEIVGGYFANSLAIMTDAAHLLTDIGAMFLSLFAMWISQHPPTSSMSFGFHRAEILGALVSVLMIWALTGVLVYEAIQRILYPPDAVDGKIMFIIASCGLFINIIDAIILHWGSGGHGHSHGGGHGHSHGIGGGTQKKKSKKNRLLNNQGQDIEDLGGENGKNKKGVRNINVHSAYIHVLGDCFQSIGVMVASCIIWVHPHWKIADPITTLIFSVIVLGTTIKLLRESLGVLMEGVPPEIDVSEVKGDLSEIEGVTEVHDLHIWSITLGRPALSVHLTILPTIDPEEILSIANKILLEDYEINHTTIQIEKPLVKDKCKDHSCPPPKPKKKKIKNDNLSSPPNQ", "function": "May be involved in zinc transport from the cytoplasm to either intracellular organelles or extracellular spaces.", "AFDB_id": "AF-Q54QU8-F1-model_v4" }, { "swissprot_id": "O43076", "sequence": "MITPKFELRQDEEFVYLDVHTPYIKAKNVEIDAFNNEVNFCIAPYFLKLELPGNVLDDDRANASYDISSGFVHIKFPKETPGEVFPDLDLLTTLLVNQNKEPVKKPLIEEVEDTPSPSTSQNASKDEEKEVKIDWQNIHFDDPDFDWGLLQRLDDEKMQYTSTSQYGFNNQYSGLLKYNALVGNEINQIPEPERTPPSTRSEIRVQLEDEKFDAEHYMADFYDREMIDEILHYIPDYIGEFLLVQQGKSDRLLEFTSEEKEALAKLPKRSYLIDNPKNVYLCLVPLIFAYAYDNRTTLGDPTIESCWNIGTLSSTISCLDTNFLAIKDIFIACIRRSLAYPLYRNWDLALTCWKDTHAILSLGKRWILRVLLRIRNLFEHHDVYYIYNAIVLNDYAYWIQTANDNVLAALAYQVSECTITKEETNWPLEEIEANVQETIIASDEESESIEK", "function": "Involved in the early biogenesis steps of box H/ACA snoRNP assembly.", "AFDB_id": "AF-O43076-F1-model_v4" }, { "swissprot_id": "Q99332", "sequence": "MNLLIDRMENPGSRNCTLLPPSFPRGFCKGRRASSGDAVKIKESGLQPQPQPEPLQAKTNVAHFSKSSSRLPVIAVNDNPVVPRPSTEVNLGSLLQKEREKEKEEQPALHDRRHLYVTKNRAHGVRQRSLEMTSLPVLGSTKTGKFSDFLFEDDIDNRVGRHSRSYSGASSLDDPFRVSPKTDFNSNRARLSCLSKGRRGSMSVFQSCHTGLAFNQIQGSSSSQRRSSAGSFDYERKRLVNQFLQPSLGNSDPFDTLRESVVFEPSSTAGGIKLGNMHSQSQISVNSSPSTSLFYHDLDGSAVNDSSSFLYSRSNVPAFLSSSAFSSTSSTSSDSEDVDRRSLNGVYPSLGYLTNQRKPRNSSGSSTAPGTDTLGFKYLLNRQKSADSSTRFKSVLKVNNNNGSAATPDSSSNSISKSNSNLNDNIDELNYYQNHISTLLVKIENEMRRNLNDTIIKNENNVQKTIQKYDLLSGELTLLLDEMTTLRTTVINQFLVKLKSDFDEDDNKAFINELKISVEESVAQLQGLERRMEVCQERLNKQKSSLREMDSLIELKNVLNKSKNNTKSIYLYRYFIIDIIAFLLMGGFIVYVKNLLTRFFTR", "function": "Calcineurin-dependent protein required for growth under high NaCl, alkaline pH and cell wall stress.", "AFDB_id": "AF-Q99332-F1-model_v4" }, { "swissprot_id": "Q7LXL5", "sequence": "MVIRIYADDREKASGIPELLKELGITVIFSQLTVADYVITDDVAVERKSVNDLVNSVFDKRFFDQISRLSEVYRFPILLVEGDINDIRKITEKWRAINNALISATIDYDVKVFYSRDKKDTAEVLKKIAEKFQFGENKSNRISLHNKAKLESVSDIQLYIVESFPNVGSILAERLLLKFGTIQNICNASISELEKALGSRKKAEDIYKILRTHYSKTNLDNDSKKTTSLFDFL", "function": "A structure-specific endonuclease, cleaves 5' of ds/ssDNA interfaces in 3' flap structures, although it also cuts bubble, Y-DNA structures and mobile and immobile Holliday junctions. Cuts preferentially after pyrimidines, may continue to progressively cleave substrate upstream of the initial cleavage, at least in vitro. May be involved in nucleotide excision repair.", "AFDB_id": "AF-Q7LXL5-F1-model_v4" }, { "swissprot_id": "Q8GWE6", "sequence": "MAYVSMGEAHRRITEYLNRFCDAVSYQDSSTLCRLLSFSSNSPPLLSLADALNVFQDSSSLIRQSDRFSEYGEILAHVFRSLQSYRVGNLVEAYLAFDKFANAFVQEFRNWESAWALEALYVVCYEIRVLAEKADKDLTSNGKSPEKLKAAGSLLMKVFGVLAGKGPKRVGALYVTCQLFKTYFKLGTVNLCRSVIRSIETARIFDFEEFPRRDKVTYMYYTGRLEVFNENFPAADTKLSYALQNCNPKRERNIRMILKYLVPVKLSLGIIPKDELLRNYNLHEYTKIVQALRKGDLRLLRHALQEHEDRFLRSGVYLVLEKLELQVYQRLMKKIYINQKLSDPARAHQLKLEGIAKALRWLDMDMDLDEVECIMTILIYKNLVKGYLAHKSKVVVLSKQDPFPKLNGKPVSS", "function": "Involved in the regulation of ethylene response. Probable TREX-2 component required for nuclear RNA export. The TREX-2 complex (transcription and export complex 2) functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.", "AFDB_id": "AF-Q8GWE6-F1-model_v4" }, { "swissprot_id": "Q96YC2", "sequence": "MNNPYENWINFFQEALNTNIPSIEKIEELVYLGIGGSGIPGRILEILELPVKYQLFRGYKVKVNEKSTVIAVSYSGNTTETIFALLTSLKKTRKAIVITSGGKIEEIASKHNLPVIKLPKGLQTRFVFPYIFTYLIRIINEGLGTNYNVNELVEGIKDYSKLNEISGILASQIIGKIPIIYSSTFLPIAERFKQEINENAKYPAFYNELPEANHNEIELYSYPSPYTFYPIVIVSDKLDEESANLINAYKIYPLYQSILKNIASLTLLAGLTSVKLAMLLGVKPEQLNIIPKIREKTFKLFEGDINADQNL", "function": "Involved in the synthesis of UDP-N-acetylgalactosamine (UDP-GalNAc). Catalyzes the conversion of glucosamine-6-phosphate (GlcN-6-P) to galactosamine-6-phosphate (GalN-6-P).", "AFDB_id": "AF-Q96YC2-F1-model_v4" }, { "swissprot_id": "P34443", "sequence": "MSSSLQSNRQSLNRKVAVMGYPHVGKSALVLRFTQNIFPERYESTIEDQHSKHIAAFHRDYHLRVTDTAGQQEYTVFPRSCSLDINGFILVYAIDDRKSFEMCSNIYEKIVRTYGDTSIPIVIVGNKTDLSTQRVVRAEEGEELARQWDAKFVEITARESNRVHEVFELLLREIEISRGNLSPTERPNGNSPKRNPFKDDGKPCSIS", "function": "Binds GTP and exhibits intrinsic GTPase activity.", "AFDB_id": "AF-P34443-F1-model_v4" }, { "swissprot_id": "A1TZ52", "sequence": "MSEDSQWLLDWPVSGGARAGRAELKTSPEDFRVTESLWPTREDDAAASGPVEVSGDGEHLCLRLEKTGDNTEYVARELAALAGCRSFDVGFCGLKDRHAVTVQWFSLYRPGQEADDQALMAEVGQRWPVRAAVRHSRKLRRGDHQANGFEIVLRNVTGQRELVEAGLERLASQGAPNYFGPQRFGFQGGNLDRAVQIDPSRLNRKRGRAGRSASKNVLYFSAARSWLFNQVLAERVSNRTWTEVLPGEPEPSGAGPTGPLWGDGGTLASGEQETLERGVVDACPGLARLFQSTRMKPERRPLVAHPGEFKWQWLDTTTLRVQFVLSPGQYATTVLGDLFELEDLSLSRDNK", "function": "Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.", "AFDB_id": "AF-A1TZ52-F1-model_v4" }, { "swissprot_id": "O67010", "sequence": "MEIVQEGIAKIIVPEIPKTVSSDMPVFYNPRMRVNRDLAVLGLEYLCKKLGRPVKVADPLSASGIRAIRFLLETSCVEKAYANDISSKAIEIMKENFKLNNIPEDRYEIHGMEANFFLRKEWGFGFDYVDLDPFGTPVPFIESVALSMKRGGILSLTATDTAPLSGTYPKTCMRRYMARPLRNEFKHEVGIRILIKKVIELAAQYDIAMIPIFAYSHLHYFKLFFVKERGVEKVDKLIEQFGYIQYCFNCMNREVVTDLYKFKEKCPHCGSKFHIGGPLWIGKLWDEEFTNFLYEEAQKREEIEKETKRILKLIKEESQLQTVGFYVLSKLAEKVKLPAQPPIRIAVKFFNGVRTHFVGDGFRTNLSFEEVMKKMEELKEKQKEFLEKKKQG", "function": "Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.", "AFDB_id": "AF-O67010-F1-model_v4" }, { "swissprot_id": "O15014", "sequence": "MSLSSGASGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDTSKPTPGTSLFTPSEGAASKKEVQGRSGDGANAGGLVAAIAPKGSEKAAKASRSVAGSKKEKENSSSKSKKERSEGVGTCSEKDPGVLQPVPLGGRGGQYDGSAGVDTGAVEPLGSIAIEPGAALNPLGTKPEPEEGENECRLLKKVKSEKMESPVSTPAVLPIHLLVPVVNNDISSPCEQIMVRTRSVGVNTCDVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGTLLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPNSNTPVNETATASDSKGTSNSSKTRAGANSKGRRGSQNSSEHRPPASSTSEDVKASPSSANKRKNKPLSDMELNSSSEDSKGSKRVRTNSMGSATGPLPGTKVEPTVLDRNCPSPVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEEPILHADLGSCNGASVSQKGSLSPARSATPKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDTDLGALSNDGSDDGPSVMDETSNDAFDSLERKCMEKEKCKKPSSLKPEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAASPGSSSGLTATVAQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKESSKELESPLTPGKVCRAEEGKSPFRESSGDGMKMEGLLNGSSDPHQSRLASIKAEADKIYSFTDNAPSPSIGGSSRLENTTPTQPLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDGEGKVDSVKSKDAEQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPSYAQSSPGALNPSSQAGVESQALKTKRDEEPESIEGKVKNDICEEKKPELSSSSQQPSVIQQRPNMYMQSLYYNQYAYVPPYGYSDQSYHTHLLSTNTAYRQQYEEQQKRQSLEQQQRGVDKKAEMGLKEREAALKEEWKQKPSIPPTLTKAPSLTDLVKSGPGKAKEPGADPAKSVIIPKLDDSSKLPGQAPEGLKVKLSDASHLSKEASEAKTGAECGRQAEMDPILWYRQEAEPRMWTYVYPAKYSDIKSEDERWKEERDRKLKEERSRSKDSVPKEDGKESTSSDCKLPTSEESRLGSKEPRPSVHVPVSSPLTQHQSYIPYMHGYSYSQSYDPNHPSYRSMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARASPSVTCKSSSESKALDILQQHASHYKSKSPTISDKTSQERDRGGCGVVGGGGSCSSVGGASGGERSVDRPRTSPSQRLMSTHHHHHHLGYSLLPAQYNLPYAAGLSSTAIVASQQGSTPSLYPPPRR", "function": "Involved in the regulation of myoblast proliferation during myogenesis.", "AFDB_id": "AF-O15014-F1-model_v4" }, { "swissprot_id": "P0C5R9", "sequence": "MRPVVSTGKAWCCTVLSAFGVVILSVIAHLFNTNHESFVGSINDPEDGPAVAHTVYLAALVYLVFFVFCGFQVYLARRKPSIELR", "function": "Accessory component of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.", "AFDB_id": "AF-P0C5R9-F1-model_v4" }, { "swissprot_id": "P27609", "sequence": "MAFEDRCSPSQANSPGPVTGRVPAPHAETLAYSPQSQYTCTTIESKYERGSPNMTIVKVQPDSPPPSPGRGQNEMEYQDYYRPETPDVKPHFSREEQRFELDRSRGQRLQPTTPVAFSINNILHPEFGLNAIRKTSKIEGPKPIGPNHSILYKPYDLSKPDLSKYGFDYLKSKETSDCNALPPLGGLRETVSQIGERLSRDREPPKSLEQQKRPDSASSIVSSTSSGAVSTCGSSDASSIQSQSNPGQLWPAWVYCTRYSDRPSSGPRSRRVKKKAAPEEKRPRTAFSGAQLARLKHEFAENRYLTERRRQSLAAELGLAEAQIKIWFQNKRAKIKKASGQRNPLALQLMAQGLYNHSTVTESDDEEEINVT", "function": "This protein might be involved in the compartmentalization of the silk gland.", "AFDB_id": "AF-P27609-F1-model_v4" }, { "swissprot_id": "Q55CX9", "sequence": "MDPIIQTIQLFQHTLHHDANVIKAAEAQLQQIKVTDGYSRILLKILASNEVDISIRQGVSIFLKNMIITKWRGAEDESPITQEDAEFIKENLIDLLVHSHHLVQNQIEAMIEIIANRDFPEKWTSLLPKSIQYINTQDVKLILAGLTSIQLGIKRFRYVTMGDKKKELLYTIVNEIFPLLLQILEFLSQHQTIESALMQKKVIKIFGYAIHFEIPDLLIQPEVFNKWLSQFVRIIQRPITPQENVKHADDCRKNQWWLLKRTTAKLLNLLFRKSATSVRSTDHSSVKALNKLFMPVYSVEVMKVFYEQLSTLEQLYKGVHYERYQQKLIEYFSFAIKYGVTYVAMKPWLSTLIQQVLFPIICFNDRDAELWECDPNEFLRSQFESSMTFATARIEVLNFIIDVVGKRGRANLDMIMGFCIQSLNKYNAATNASEKNPREKDGVLVIISVLSAYLKNISFYKSNLEQMLLLHVFPELSSPHGFLKARACSLFSEFYNIEFTDPVYFSNALKLILGLMSDNDLPVRVKAGTSICNLVRANQGVDELRPILPQLLDKIFSLLSEAESEDLVIAIESIIQRFKHEIAPYAVNLCKNLSEQFLRLLELEESDESGESGFASQECLGVYCTLLRALKDIPDVFNSLEQQIVPILQKLFTSDHMMYLDEALRILTFVTYYPKSISPLVWSLFPQIMNLFDECACDFASSYVNPLDNYISYGTEYFLSNQQYIEMVFNMYKKMVGDINQQPVDAGDCCKIMESLIQRAKGRIDYMIVPVLELACGRLLNTDKNNQKSKEFTVYLLEIIANCIYYNPLISTQYLESKNLVEPIFGLWFNRIKHFQRFYDKKISVLAFSSLLTLNPSPNFVKFGTSLILEKMLQFTKDMLSIEKELDKQEAEREQKIKDGTLKPEEEEFIDENDEEDYFDNHKFEFEFTEIPDNQDCQHDDEGEVFLDDIEKATEYFENGGDLGEDEGDNFDDQNDDDDQDSEEDLFEDEDTPDFETPIDEVDGFEFMINSIQNFFQINPTCIQQISEKQQEKIKKYVASAPARKEKLRLEKEKEEKLKQQQQKK", "function": "May function in nuclear protein import.", "AFDB_id": "AF-Q55CX9-F1-model_v4" }, { "swissprot_id": "O23365", "sequence": "MVAAMAFPAAATYPTHFQGGALHLGRTDHCLFGFYPQTISSVNSRRASVSIKCQSTEPKTNGNILDNASNLLTNFLSGGSLGSMPTAEGSVSDLFGKPLFLSLYDWFLEHGGIYKLAFGPKAFVVISDPIIARHVLRENAFSYDKGVLAEILEPIMGKGLIPADLDTWKLRRRAITPAFHKLYLEAMVKVFSDCSEKMILKSEKLIREKETSSGEDTIELDLEAEFSSLALDIIGLSVFNYDFGSVTKESPVIKAVYGTLFEAEHRSTFYFPYWNFPPARWIVPRQRKFQSDLKIINDCLDGLIQNAKETRQETDVEKLQERDYTNLKDASLLRFLVDMRGVDIDDRQLRDDLMTMLIAGHETTAAVLTWAVFLLSQNPEKIRKAQAEIDAVLGQGPPTYESMKKLEYIRLIVVEVLRLFPQPPLLIRRTLKPETLPGGHKGEKEGHKVPKGTDIFISVYNLHRSPYFWDNPHDFEPERFLRTKESNGIEGWAGFDPSRSPGALYPNEIIADFAFLPFGGGPRKCIGDQFALMESTVALAMLFQKFDVELRGTPESVELVSGATIHAKNGMWCKLKRRSK", "function": "Heme-containing cytochrome P450 probably involved in the biosynthesis of xanthophylls. Hydroxylates beta-rings of alpha-carotene. May also have activity on beta-rings of beta-carotene.", "AFDB_id": "AF-O23365-F1-model_v4" }, { "swissprot_id": "Q5FW12", "sequence": "MMIQGFKSSNQEFKFGPWQLTAIKTHIMKSADAEKLAEEMSMPCLPEMMFGDNVLRIQHTSGFGIEFNAKDALKVVKSNQASLKVACAEEWQESRSDSEHNKEVVKPYDWTYTTDYKGTLLGDNMKLNVIPTTDKINTEKLKAREQIMFFEEVLLFEDELHDHGVSSLSVKIRVMPTSFFLLLRYFLRVDGVLIRMNDTRLYHEADKTFMLREYTSKESKISNLSHVPPPLYTEPNEISQYLPVTQTIYEKLEFPSQDLEKAVLVDTKNVTAL", "function": "May be a regulator of serine/threonine-protein phosphatases 2A (PP2A) and 4 (PP4).", "AFDB_id": "AF-Q5FW12-F1-model_v4" }, { "swissprot_id": "P19812", "sequence": "MSVADDDLGSLQGHIRRTLRSIHNLPYFRYTRGPTERADMSRALKEFIYRYLYFVISNSGENLPTLFNAHPKQKLSNPELTVFPDSLEDAVDIDKITSQQTIPFYKIDESRIGDVHKHTGRNCGRKFKIGEPLYRCHECGCDDTCVLCIHCFNPKDHVNHHVCTDICTEFTSGICDCGDEEAWNSPLHCKAEEQENDISEDPATNADIKEEDVWNDSVNIALVELVLAEVFDYFIDVFNQNIEPLPTIQKDITIKLREMTQQGKMYERAQFLNDLKYENDYMFDGTTTAKTSPSNSPEASPSLAKIDPENYTVIIYNDEYHNYSQATTALRQGVPDNVHIDLLTSRIDGEGRAMLKCSQDLSSVLGGFFAVQTNGLSATLTSWSEYLHQETCKYIILWITHCLNIPNSSFQTTFRNMMGKTLCSEYLNATECRDMTPVVEKYFSNKFDKNDPYRYIDLSILADGNQIPLGHHKILPESSTHSLSPLINDVETPTSRTYSNTRLQHILYFDNRYWKRLRKDIQNVIIPTLASSNLYKPIFCQQVVEIFNHITRSVAYMDREPQLTAIRECVVQLFTCPTNAKNIFENQSFLDIVWSIIDIFKEFCKVEGGVLIWQRVQKSNLTKSYSISFKQGLYTVETLLSKVHDPNIPLRPKEIISLLTLCKLFNGAWKIKRKEGEHVLHEDQNFISYLEYTTSIYSIIQTAEKVSEKSKDSIDSKLFLNAIRIISSFLGNRSLTYKLIYDSHEVIKFSVSHERVAFMNPLQTMLSFLIEKVSLKDAYEALEDCSDFLKISDFSLRSVVLCSQIDVGFWVRNGMSVLHQASYYKNNPELGSYSRDIHLNQLAILWERDDIPRIIYNILDRWELLDWFTGEVDYQHTVYEDKISFIIQQFIAFIYQILTERQYFKTFSSLKDRRMDQIKNSIIYNLYMKPLSYSKLLRSVPDYLTEDTTEFDEALEEVSVFVEPKGLADNGVFKLKASLYAKVDPLKLLNLENEFESSATIIKSHLAKDKDEIAKVVLIPQVSIKQLDKDALNLGAFTRNTVFAKVVYKLLQVCLDMEDSTFLNELLHLVHGIFRDDELINGKDSIPEAYLSKPICNLLLSIANAKSDVFSESIVRKADYLLEKMIMKKPNELFESLIASFGNQYVNDYKDKKLRQGVNLQETEKERKRRLAKKHQARLLAKFNNQQTKFMKEHESEFDEQDNDVDMVGEKVYESEDFTCALCQDSSSTDFFVIPAYHDHSPIFRPGNIFNPNEFMPMWDGFYNDDEKQAYIDDDVLEALKENGSCGSRKVFVSCNHHIHHNCFKRYVQKKRFSSNAFICPLCQTFSNCTLPLCQTSKANTGLSLDMFLESELSLDTLSRLFKPFTEENYRTINSIFSLMISQCQGFDKAVRKRANFSHKDVSLILSVHWANTISMLEIASRLEKPYSISFFRSREQKYKTLKNILVCIMLFTFVIGKPSMEFEPYPQQPDTVWNQNQLFQYIVRSALFSPVSLRQTVTEALTTFSRQFLRDFLQGLSDAEQVTKLYAKASKIGDVLKVSEQMLFALRTISDVRMEGLDSESIIYDLAYTFLLKSLLPTIRRCLVFIKVLHELVKDSENETLVINGHEVEEELEFEDTAEFVNKALKMITEKESLVDLLTTQESIVSHPYLENIPYEYCGIIKLIDLSKYLNTYVTQSKEIKLREERSQHMKNADNRLDFKICLTCGVKVHLRADRHEMTKHLNKNCFKPFGAFLMPNSSEVCLHLTQPPSNIFISAPYLNSHGEVGRNAMRRGDLTTLNLKRYEHLNRLWINNEIPGYISRVMGDEFRVTILSNGFLFAFNREPRPRRIPPTDEDDEDMEEGEDGFFTEGNDEMDVDDETGQAANLFGVGAEGIAGGGVRDFFQFFENFRNTLQPQGNGDDDAPQNPPPILQFLGPQFDGATIIRNTNPRNLDEDDSDDNDDSDEREIW", "function": "Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.", "AFDB_id": "AF-P19812-F1-model_v4" }, { "swissprot_id": "P31736", "sequence": "MRVARLPLLHPHRAAPVVRRQLRGSSLLEMLLVIALIALAGVLAAAALTGGIDGMRLRSAGKAIAAQLRYTRTQAIATGTPQRFLIDPQQRRWEAPGGHHGDLPAALEVRFTGARQVQSRQDQGAIQFFADGASTGGRIDLTIKDARWRVDVGWITGEVRSGPLRTPAP", "function": "Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.", "AFDB_id": "AF-P31736-F1-model_v4" }, { "swissprot_id": "P32481", "sequence": "MSDLQDQEPSIIINGNLEPVGEPDIVEETEVVAQETQETQDADKPKKKVAFTGLEEDGETEEEKRKREFEEGGGLPEQPLNPDFSKLNPLSAEIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEPTCPEPDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTKDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKTDGQKQAKVRKLEPNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKKGTTLEPIA", "function": "As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B.", "AFDB_id": "AF-P32481-F1-model_v4" }, { "swissprot_id": "A0A0B5A7M7", "sequence": "MATSLLSPLLVAMLGFLLHVHVARAGLEHTCTLETRMQGAHPQGICGSKLPDIVHTVCQVMGRGYAGGQRQLRKRTSMIDSDDMEAEGGSRGGFLMSKRRALSYLQKETNPLVMAGYERRGIQKRHGEQGITCECCYNHCSFRELVQYCN", "function": "This venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock. Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In vivo, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.", "AFDB_id": "AF-A0A0B5A7M7-F1-model_v4" }, { "swissprot_id": "Q9WU72", "sequence": "MDESAKTLPPPCLCFCSEKGEDMKVGYDPITPQKEEGAWFGICRDGRLLAATLLLALLSSSFTAMSLYQLAALQADLMNLRMELQSYRGSATPAAAGAPELTAGVKLLTPAAPRPHNSSRGHRNRRAFQGPEETEQDVDLSAPPAPCLPGCRHSQHDDNGMNLRNIIQDCLQLIADSDTPTIRKGTYTFVPWLLSFKRGNALEEKENKIVVRQTGYFFIYSQVLYTDPIFAMGHVIQRKKVHVFGDELSLVTLFRCIQNMPKTLPNNSCYSAGIARLEEGDEIQLAIPRENAQISRNGDDTFFGALKLL", "function": "Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.", "AFDB_id": "AF-Q9WU72-F1-model_v4" }, { "swissprot_id": "Q9FN48", "sequence": "MAMAEMATKSSLSAKLTLPSSSTKKTLSLRQVSVSLPTSTSISLLSLFASPPHEAKAAVSIPKDQIVSSLTEVEKTINQVQETGSSVFDATQRVFQVVGDALKPALDTALPIAKQAGEEAMKLASPAFSEASKKAQEAMQSSGFDSEPVFNAAKTVTDVAQQTSKAIEDAKPIASSTMDTISSADPSVIVVAAGAAFLAYLLLPPVFSAISFNFRGYKGDLTPAQTLDLLCTKNYLMVDIRSEKDKEKAGIPRLPSNAKNRVISIPLEELPNKVKGIVRNSKRVEAEIAALKISYLKKINKGSNIIILDSYTDSAKIVAKTLKVLGYKNCYIVTDGFSGGRGWLQSRLGTDSYNFSFAQVLSPSRIIPAASRSFGTRSGTKFLPSSD", "function": "Modulates cytoplasmic Ca(2+) concentration and is crucial for proper stomatal regulation in response to elevated levels of external Ca(2+). May function by regulating concentrations of inositol 1,4,5-trisphosphate (IP3), which in turn triggers release of Ca(2+) from internal stores. May play a role in de-etiolation.", "AFDB_id": "AF-Q9FN48-F1-model_v4" }, { "swissprot_id": "Q6TGJ8", "sequence": "MGKGKNHDRKANPGFGKVKSKSGTSTGEFTLKRVKGENFYRDAKSAARVKMLNGGKAVRDRDGKIVEAAAFQKGEKEAEPGRVKPDRRWFGNTRVISQSALDHFRTALKEQKADPYSVLLKRNKLPMGLLQDDTKDSGSRPHIVETEPFGDTFGPKAQRKRPRLDIGSIEELGESSAAAATAAEAATAESQANGTADLADIYHPTTSTAREPIYAKGTSRRIWGELYKVLDSSDVVIHVLDARDPLGTRCKPVVEYLRKEKAHKHLVYVLNKVDLVPTWVTSGPYAYAYANGPARWVKHLSLSAPTIAFHASINNSFGKGSLIQLLRQFSVLHSDKKQISVGFIGYPNTGKSSIINTLKKKKVCTVAPIPGETKVWQYITLMRRIYLIDCPGIVPVSAKDSDTDTVLKGVVRVENLATPAEHIPALLERVRPEYLERTYNLEHVEGGWHGEQGATVILTAIAKKSGKLLKGGEPDQEAAAKMVLNDWIRGKIPFFVAPPAKSEPGAPTAATAAAATTTEAEKKKTEAEEQELAEERETMEILEEQERSLGKVLGIKRVKGVEQPISKIVTMTKFIGDDARRYVEEEEVVDQDKEMVEKEEEEEEEEDEDEDEEEEELAWEDVFPEEADAVDGGEEVEESDKEETDDEEDVDEEEAVPSAKQLGKRKAIDSDEEEQTANKSKRMTTNKQKATNFYTHANVKNRNRDRKVPKNPGKRSRGDDETTGKKAKKRR", "function": "GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.", "AFDB_id": "AF-Q6TGJ8-F1-model_v4" }, { "swissprot_id": "P42505", "sequence": "MDIDALSLNELKALRSKVDRAIVTYEERKKKEAFAELDEIARKMGYPLAEILTMVETKPRKTVAAKYANPANPSETWTGRGRKPKWVEAALASGKSLEDLTI", "function": "A dim-light trans-acting activator of Puf and Puh expression, that has no effect on the expression of the Puc operon. Responsible for regulating light-harvesting-I and reaction center structural gene expression differentially from that of light-harvesting-II expression in response to alterations in light. Proper light regulation of light-harvesting and reaction center polypeptide synthesis is an important physiological trait that enables cells to adapt to ever-changing environmental conditions of light intensity.", "AFDB_id": "AF-P42505-F1-model_v4" }, { "swissprot_id": "Q9X404", "sequence": "MPARNHTQWMATPPLQKGEWVDSRVYTDQEIFDEELEKIFKKAWVPFRHESELPKAYDFRTTSIANEPIIVTRGPDNEVRAFLNVCPHRGMLIERRPSGSLYEGQPSGNPKRMTCMFHAWQFDMKGNCVYISREKEGYQDRLPKESVGLRRLRCEVKFGGFVWVNLDDNPISLEDWAGEPFQCLRKTLEAEPMEVFHYHKAIVDTNYKLWHDTNCEFYHDFMHYHNRVTGFNDAYFARKNESFEHGHILVGTFEVNYDQYEGFESRAGLSFPHLPPNQWYMIDLFPGMNFNLRGSALRCDVVTPLGPNKVMIEFRGLGLKSDTPEERQTRINHHNSIWGPFGRNLHEDLIGVQGQGTTMRPGQESRRILHGRQENQTIHDENGMRHYYDKWGKWMNRMPSNPELPYNAPAIAAE", "function": "Methanesulfonate monooxygenase (MSAMO) mediates the primary degradation of methanesulfonic acid (MSA) to produce formaldehyd and inorganic sulfite by initial hydroxylation of the carbon atom prior to spontaneous cleavage of the unstable hydroxymethanesulfonic acid. MSAMO has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methane- to butanesulfonate) and excludes all larger molecules, such as arylsulfonates and aromatic sulfonates. All MSAMO components are required for enzyme activity.", "AFDB_id": "AF-Q9X404-F1-model_v4" }, { "swissprot_id": "P30199", "sequence": "MNKFKFFIVFLILSLVFLQNEYAFGSSLNEELSYYSVEYDNAKTFKESIKQKNIELTYKIPELHTAQIKTSKSKLNSLIKSNKNVKFVNPTCSTCVVEKSVKTGKNLNNKKNGSHDLFDRQWDMRKITNEGKSYKLSPDRKKAKVALVDSGVNSSHTDLKSINKIVNEVPKNGFRGSENDESGNKNFEEDKLNHGTLVAGQIGANGNLKGVNPGVEMNVYRVFGSKKSEMLWVSKGIIDAANDDNDVINVSLGNYLIKDNQNKKKLRDDEKVDYDALQKAINYAQKKGSIVVAAVGNDGINVKKVKEINKKRNLNSKTSKKVYDSPANLNNVMTVGSIDDNDYISEFSNYGNNFIDLMTIGGSYKLLDKYGKDAWLEKGYMQKQSVLSTSSNGRYIYQSGTSLAAPKVSGALALEIDKYQLKDQPETAIELFKKKGIEKEKYMDKKHYGNGKLDVYKLLKE", "function": "Protease which cleaves the matured lantibiotic from the modified prepeptide.", "AFDB_id": "AF-P30199-F1-model_v4" }, { "swissprot_id": "Q9VR56", "sequence": "MDTTEKALKEVTPAMLSLNNCPGTTPGTPMSKNQLKKQRKLAEFAELRKLRREREREKKKQKRREAKELGLPVRTGPSRKELKKRQLADGGKSGLSVAIDLDYDDLMQERDIVKCVKQCLRIYTINRRSPQPGNLHFTGIRRNGHIHESFKKNEGWENWHVQYYFDRGHTDIFEHSQLVYLTCESDRVLDKLQPGCTYVIGGLVDHNHFKGLCHSRATSAGLTTARLPLSEHVDMKTRAVLSTYHVFELLTKVAAGQDWTTAILETIPMRKGAKAKITDKKEPNHCLEQQDEKQKQEAESDKPTLTAVESEIESHSLDS", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs.", "AFDB_id": "AF-Q9VR56-F1-model_v4" }, { "swissprot_id": "Q8ZCA7", "sequence": "MLQTTLLALQGLSCMNCAQRVKAALESREDVHHAEVNVHYAKVTGEADTHALIETIKQTGYQATEAQTPDVELHLSGLSCGHCTETVRKALEAVSGVISADVTLESANVYGKADIQTLIAAVEQAGYHATQQGIDSPKTEPLTHSAQSQPESLAAAPNTVPATNVALATSTVSDTNTVLPTNTALPTNTTSTTSTADTASATSTAPVINPLPVTESVAQPAASEGESVQLLLTGMSCASCVSKVQNALQRVDGVQVARVNLAERSALVTGTQNNEALIAAVKNAGYGAEIIEDEGERRERQQQMSQASMKRFQWQAALGLLLGIPLMAWGLFGGSMTLTPETQTPWLIIGIITLLVMIFAGGHFYRNAWVSLKNGRATMDTLVALGTGAAWIYSITVNIWPDVFPMEARHLYYEASAMIIGLINLGHAMEQRARQRSSNALERLLDLAPPTAKLVTDDGEKVIPLADVQLGMILRLTTGDRVPVDGEIVQGEVWMDEAMLTGEPIPQQKSVGDIVHAGTQVQDGTVQFRASAIGSQTTLARIIKLVRQAQSSKPEIGKLADRISAVFVPTVVVIAIVAGLIWYFFGPQPQLVYTLVVATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRDADALQQASNLDTLVFDKTGTLTEGHPQVVAIHTFNGVSEQQALGWAAALETGSNHPLARAILQRAEGLTLATASQFRTLRGLGVSGEVDGIPLLLGNNRLLEEQQIDTRELQSLIQQQAESGATPVILTANGKPAALLSIRDPLREDSIGALQRLHQLGYSLVMLTGDNPITANAIAKEAGIDRVIAGVLPDGKADAIKQLQAAGHKVAMIGDGINDAPALAQADVGIAMGGGSDIAIETAAITLMRHSLYGVVDAVELSKATLRNMKQNLLGAFFYNALGIPIAAGILYPFTGTLLSPVVAGAAMALSSITVVSNANRLLRFKPKQ", "function": "Involved in copper export.", "AFDB_id": "AF-Q8ZCA7-F1-model_v4" }, { "swissprot_id": "Q97C35", "sequence": "MDRAFCGNFYYNGKFDYLEVTVKDGVIESIKKDAGNIARSYLPGAVLPAATDIHVHFRTPGETDKEDFSTGSLSAIFGGTTLVMDMPNNIIPIKDYNAFSDKLGVINGTSYSDFALYSMETGSNSLIVDSRSIGLKVYLGGSTNAAGTMAIPDQEAEMINEKGFTVIFHGELEECLRKHQSETKNLREHNLSRPIECELAAAGYVGSLNLKSKIMAHVSSPEVSGDFLREVTPHHLLLNDEMPLGSIGKVNPPLRDRNTQERLLYAYISGQFDILSSDHAPHTEKDKAEFEYAKSGIIGVETRIPLMLALVKKKILFLDVLYKTGIERPPSIFGIRKGKIEVGYDADFMCVDFTNEKKVNEDRLHSKLPRSPFNGMDAIFPSHVVMRGEVVIDNYEEISDPLGRFVPKGYYDQKL", "function": "Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.", "AFDB_id": "AF-Q97C35-F1-model_v4" }, { "swissprot_id": "Q032G9", "sequence": "MTQAQKLSAQEIIQFIGNAEKKTQVKVTLSGMPSFKSAGFLAENGRPNFKALANKGIQVLGDFHTHYSLKIIIGDWQAVRPLLEGLTENKDYTIEFEGRNSAVPLLDTRAINARIEPGAIIRDQVMIGDNAVIMMGAIINIGAEIGEGTMIDMGAVLGGRATVGKNSHIGAGAVLAGVIEPASAEPVRVGDNVLVGANAVVIEGVQVGSGSVVAAGAIVTQDVPENVVVAGVPARTIKEIDEKTAQKTALEDALRNL", "function": "Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.", "AFDB_id": "AF-Q032G9-F1-model_v4" }, { "swissprot_id": "C1FN35", "sequence": "MENWNKYIPEGMKDILFKESNIKLNIEDQLRKIYKYSGFSEIISPTIEFYDVFNSNIQAIPQEKMYKLFDNLGRILVLRPDMTTPIGRITGTKMKDCTYPLKLCYTANIFRVNEKLNGKRGEITQSGIEIIGTNGIKSDVDSIVTAINALLSVGLKNFKIELGEAGFFQALTENMEIKEENLKKLKEIIRNKNYVALKKFLDEISSKYSKEDFELIKNLPKLFGDIKIIEKAKALTKNKKALKSLDDIHNIYKSIENIGLEAYISIDLGMVQNIDYYTGVIFKGYVEEVGDSILSGGRYDNLIQHFGIELPATGFAINVDDIMIALKKQNTMSMDKDKKVLIFYKEEFLRKAYDFMQELKMKKIICELSLLDDDKEILLYSKKKGIDFIIGFMGEEKLFVKDLKSDKIAFLKKDEIENLLML", "function": "Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.", "AFDB_id": "AF-C1FN35-F1-model_v4" }, { "swissprot_id": "Q5ATK1", "sequence": "MAKLYYMPYIFNEGMPLASGPPTLPEDFTPEKSGFRVLVEVRRMKGHFPAQKWRKRNQEWQCINNETLLPDHVRNGHLAKNVPYRPYRPVYVPFAMTVSPTTDAMGTSEETRSKQTKGSNDDILSAKIAGRVARPVYHCTSARLHDLAYDPWPITTIDTHGLSSLKAPSTHTRILIIGAGFGGLLFAVRLLQAGFSRDDLLLVDSAGGFGGTWYWNRYPGLMCDIESYIYMPLLEETGHMPSRKYVPGEELRTHAEGIAAKWELEQRALFRTTIRTLEWDEGGNQWIAHAEQLGVFTDAKQGGNGGGGPLTFTATFAIIASGTLSKPKVPNLHGVDDFQGHIFHTARWDYDYTGGSPANPAMHRLQGKRVGVIGTGSTAVQVIPQLARWSKELIVFQRTPAAVGLQKNQVTDPVWWKGNILKAGSGWQRKRSENFNAFISISNPPCMENLVNDGWTSSPSFSAAIGGALNMQPDFLDLVKAIDRPRLEAAQDHIRSTVRDDTTAEALINLNHGWCKRPCFHQGYFETYNLPHVRLIKTDAAGVTGLSPKGILVGDTLYEVDLVVLATGYDLGSLCPADRAQIQVLGSEGVAMKEKWAGGPTTLHGVMTRGFPNLFFPGTSQAGVTANQSYMFDRAAEHVAYIIQNSTLEAGGYIDKIRIEPTAEGEKHWTTQSVARISAFAATTACGTGDYTISNRYRSSDVDTMARHMPWGEGMASYVKILEAWRESGTMEGLDIRYHSSEGSR", "function": "FAD-binding monooxygenase; part of the gene cluster A that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids. The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA. 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN. Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A. Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE. Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4. The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide. Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol. Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation. Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional.", "AFDB_id": "AF-Q5ATK1-F1-model_v4" }, { "swissprot_id": "O32144", "sequence": "MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPHAEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVAAETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEGFQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFDIPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHPMKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGISVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEHRIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRLSLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTASRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKELAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAAGPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLIAIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKGLKQWT", "function": "Oxidizes hypoxanthine and xanthine to uric acid.", "AFDB_id": "AF-O32144-F1-model_v4" }, { "swissprot_id": "Q12052", "sequence": "MGRTFIHASKIKHAARKRKHHSNFRTLIKLLNNDAYKIESSKPLKNGKLFKYWKNRRRLFSKIDSASIYMTDELWFSVTPERIACFLANFVKACMPNAERILDVFCGGGGNTIQFAMQFPYVYGVDYSIEHIYCTAKNAQSYGVDDRIWLKRGSWKKLVSKQKLSKIKYDCVFGSPPWGGPEYLRNDVYDLEQHLKPMGITKMLKSFLKLSPNVIMFLPRNSDLNQLSRATRKVLGPFAKCKVLYVKENGYMKGIFCMWGECFFNYEPASTENSRRESSEKEELSSENEELSKRKKHESTTTTKDNTVDIYDVNG", "function": "Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylates the m3G cap on TLC1 telomerase which affects telomere silencing and telomere length regulation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization.", "AFDB_id": "AF-Q12052-F1-model_v4" }, { "swissprot_id": "Q9UTN9", "sequence": "MRMDEFYTKVYDAVCEIPYGKVSTYGEIARYVGMPSYARQVGQAMKHLHPETHVPWHRVINSRGTISKRDISAGEQRQKDRLEEEGVEIYQTSLGEYKLNLPEYMWKP", "function": "Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts. The DNA is bent, the damaged base is rotated out of the DNA duplex into a hydrophobic binding pocket (nucleotide flipping), with Arg-39 donating a hydrogen bond to the orphaned cytosine to stabilize the extrahelical DNA conformation. This structural change in DNA presents the lesion to the nucleotide excision repair (NER) pathway. The affinity for O(6)-alkylguanine adducts increases with the size of the alkyl group. Low affinity small O(6)-alkylguanines are directed to the global genome repair pathway of NER via rhp7-rhp16 and rhp41-rhp23, while strong binding to bulky O(6)-alkylguanines stalls the transcription machinery and diverts the damage to the transcription-coupled repair pathway of NER via rhp26.", "AFDB_id": "AF-Q9UTN9-F1-model_v4" }, { "swissprot_id": "Q9XES0", "sequence": "MAPTEIKTLSFLDSSKSNYNLNPLKFQGGFAFKRKDSGCTAAKRVHCSAQSQSPPPAWPGRAFPEPGRMTWEGPKPISVIGSTGSIGTQTLDIVAENPDKFRIVALAAGSNVTLLADQVKAFKPKLVSVKDESLISELKEALAGFEDMPEIIPGEQGMIEVARHPDAVTVVTGIVGCAGLKPTVAAIEAGKDIALANKETLIAGGPFVLPLAKKHNVKILPADSEHSAIFQCIQGLPEGALRRIILTASGGAFRDLPVEKLKEVKVADALKHPNWNMGKKITVDSATLFNKGLEVIEAHYLFGAEYDDIEIVIHPQSIIHSMVETQDSSVLAQLGWPDMRLPILYTLSWPERIYCSEITWPRLDLCKVDLTFKKPDNVKYPSMDLAYAAGRAGGTMTGVLSAANEKAVEMFIDEKIGYLDIFKVVELTCDKHRSEMAVSPSLEEIVHYDQWARDYAATVLKSAGLSPALV", "function": "Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).", "AFDB_id": "AF-Q9XES0-F1-model_v4" }, { "swissprot_id": "Q2RL77", "sequence": "MTATGKREWTPDQLAAIRARRANILVAAAAGAGKTAVLVERIIQRLTDPEDPVSLENLLVVTFTEAAAAEMRQRIGAALEAAVARDPENEALRRQLLLLNRAHISTIHSFCLWVLRTYFYRLDLDPGFRVMDPAEVDLMQLEVMDRVLEEAFAAEPDGGPVTDLADSLGGRGDANLVDLVLRVWEFSRSLPWPEAWLEQVTSSYKVTPETPLESLPWYGELRQMITLELQEAAWYLEQARQAAAAPGGPAVYLDNLENEKEQVTRLLEEVGDLPWEELNAKLAAVHFGRLKAARGEDVDPVLKERAGKLRNQARDLLYALKEDLCRDEAAVRAELERSGELVATLVGLVRRFDAALREAKGRRNLIDFSDLEHLCLRVLLDEGAGPGRLQPSDVALELRQRFAEVLVDEYQDINTVQDAILALVSRQDVAENNLFMVGDVKQSIYRFRLANPDLFLAKYRQYPEGEGGPNRRILLKANFRSRQGVVDGVNFIFRQVFSPLVGELEYDAAAALVGRAGYPENPAAATPAVEVYLQEGKVAAGTGAGGRTDLPEAVGAGKGGKISGGAGYGETLSGYGAASPGGETGAPDLEDLTALEREALLVARRIRRMVRGTPERPGPEFQVWDQEKKEYRDLTYRDIVILLRATRDRAPVFLEALKQYGIPAYADLGSGYFAATEIETILSLLRVIDNPHQDIPLAAVLRSPIVGLSAGDLARIRLAAPGEDFFTAVVKAAGAPLLPFTARESAAPSSTATGSGGALDNQPGQDPVCIAPYIEDTQEPWRDDHPGPGAAAGKAVPGKDRDLASLLREFLARLERWRTLARRQPLGDVIWQLYRETGYLEFVGGLPGGAQRQANLRALLDRARQFEGFARHGLFRFLRFIERLQQNEGDLGTARALGENEDVVRVMSIHRAKGLEFPVVIVAGLGKGFNLRDLSGDFLLHGRLGLVPLYLDAAAGIKYPTLPYLATGHRLRLEALSEELRILYVALTRAREKLILAGTVRDLPRQAENWCASLFLPGEQLPPVLTSRAGNPLDWLLPALARHPDAAAIRDLAGVGGGHLLPDPSSWQVEVVRGGELPDRGSEEPGVQVRVTAGYQGTESAGQQENPGLLCSGWPGGSRELAGAVTPVQETAGKTVAPPGSNIAEAGVEPGVSPPAGAVSPQDETGPTWLQQEVARRLAWTYPRQPLTALPVKLTVTDLKRRFDVFNEGETPLRPGENTFTRRPAFLQSHQGLTAAERGTATHLVLQHVDLSRPVTGESLAGLLQEMVEREILTPEQAAAVDIRAIVTFFAAPLGKRLLARWEQVKRELPFSLAVPAVELYPGLPAEAAAGEIILVQGIIDCLVEEEDGFLLLDFKTGRIPPDPLAAYREQVRFYTRAVETIFNRNVKEVHLYFLDGGVDFKVTS", "function": "The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.", "AFDB_id": "AF-Q2RL77-F1-model_v4" }, { "swissprot_id": "Q89AB3", "sequence": "MITTIPKSINVTTIPLSGKILIEASAGTGKTFSLTILYIRLLLGITNHVKYKKGLLIKEILVVTFTEHTRAELEIRIKTYIKIFKTACIKKYSNNYVLSKLLSKITDFPKTIDILSKAENSIHELSIYTIHGFCYKILKLNKFNSELMLQNKILKHTYPLYLKISIKFWKYYFAFLSLDITSILLEYFNNPKTLLKEILPLLNKTQLISKLTKTKRKNIVQEYYILIKKIKLFKQKWANYSHLIHSEIIKTNVNKRIYTKSNLKRWINNITAWATQKQTKNFFIPSELKYFRYSFIIKKTTSEKILDDKFFKFIDTFLDSKFSLKEIFIIDASLEIKAMFMQEKIKNRYFEYDDLITFCWNMVNKNNFNISQTILKKYPVALIDEFQDTNNKQYNIFKKIYKKENLLILISDPKQAIYSFSGADITSYLQAKSNIKNQYFLDTNWRSSPKIINSINLLFSRLKNPFLTKNITFYPVKSSRINKTTKFEVNGKNQPALRFLLNKNKNISINEYKEWISITTAKYISYWISSGIKGNATITISNKVRTVNFSDIAIIVRNNLEAKTIQLELTKLNIQSLYLTSKNNIFQSKEILEILWILQAILNPNIERLLKRAMSTNIMSKNTKEIISIPNNHSYWIKLSQEFNQYLIFWNNYGILYVIQQLIINYNISNNNNLLHNFSPNIKNILYIGELLEEKSITIKNKFLLINWLKKNITQDFYLTKPKYIKPNYEKNNYIKIVSIHKSKGLEYPITIIPFATITFNKTVSTVEKICFNLNNTKIKKQKTLKIEKHKFSEDIRLLYVALTRSIIHCSIGISLAQTITQKKKIQKEKSKFKINVLRYIIQSGKNHISTKKLYTELSILKKNKNIEIISEIPNIIKKNFQIPTLNTNSQSLMHYQVSRKFNYNYNFTSYSQLKKNIKPSTMYSTLNTKKLFELNVKKKHCFENKILTPHTFPSGKIYGTLLHKILKNISFHKSINSNWLLKKLSEYNLDKRWCLILKNWMYSILYKNLDKNYNLRLSKLDSKNYIKELKFLLPIKKKLTALKLNNIFQTHQCSSLENKLCFHPIQGILSGSIDLVFLWKTKYFLVDYKSNWIGNSNQSYSQQNIKKIIKKHHYNFQLQLYSLVLHRYLKQHIKNYSFYNHFGGTYILFIRSINEIPSQNGIFYSIPNIEIIKKLEQIF", "function": "A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.", "AFDB_id": "AF-Q89AB3-F1-model_v4" }, { "swissprot_id": "I6Y3Q0", "sequence": "MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELWRKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLAAGALARFGSPELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGTGHGYRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAAGDPGVAVTALATTGLGSVGHLELNGAKVDAARRVGGTDVAVWLGTLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETPA", "function": "Involved in the first cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the dehydrogenation of acyl-CoA ester side chains of (25S)-3-oxo-cholest-4-en-26-oyl-CoA (3-OCS-CoA) to yield (24E)-3-oxo-cholest-4,24-dien-26-oyl-CoA. Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) as well as 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA). It dehydrogenates only (25S)-OCS-CoA diastereomer.", "AFDB_id": "AF-I6Y3Q0-F1-model_v4" }, { "swissprot_id": "Q9VS05", "sequence": "MIKSEEASDRSVMTMDQLGGYYHDPRAHPPFSHPHAHSHPHQHTHTGHPYRAGNLLTGGNYQAMGGGESPTELIDEKPNIGYMELKHYMDATPTATPVSAAQHYSLSALHSMGTPPASSSPIPPYGVLMTAHSAGSASPQSNSKTPTDLPQDLQYASSSTSTAKVQPLQVQLQPLNHQYASTIKYCSNNTILSANDYQLLTSQEQAGQQQPQQLPAQQLQHSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSSPAKSLNGSESSPPSQNHLENKVSGSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPRGYRSKIKVKPYAGHANGYYASGYGDAGMDNGNYYASPAFASYDYSAAGATGVSPAGGQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGSATTPPLAHSALGMAPSASSSSSPLGAAATLQSDYAPTASLVAAGYSYATSAGSLDNGLRSISLQQLPGLSSIQHAQAQAQAQAHHHHHQHHASHPSHSHQGHGSMHQNHGTSSTTPPPSQSGGSHGIDHSPIDRKPAYLPPISPPPMMVALNGGGGYYEGLKYAN", "function": "Component of a regulatory network controlling visceral mesoderm development and midgut morphogenesis. Transcriptional regulator involved in the activation of a large number of genes in the visceral mesoderm including betaTub60D, dpp and Hand. Binds to and regulates a number of enhancers driving expression in the visceral mesoderm in a temporally and spatially restricted manner. Also to binds to enhancers cooperatively with activators, such as bap or HLH54F, to coregulate expression of shared target genes in the visceral mesoderm. Binds to the Ndg enhancer and drives expression of Ndg in the late visceral musculature. May be involved in the transcriptional regulation of wupA in the visceral mesoderm. Plays an indirect role in the later stages of salivary gland positioning.", "AFDB_id": "AF-Q9VS05-F1-model_v4" }, { "swissprot_id": "P81732", "sequence": "DFGHSKKIRKNVHSLTAEEQNSLRRAMDDLQDDKTRGGFQQIAAFHGEPKWCPRPEAEKKFACCVHGMAVFPHWHRLLTVQGENALRKHGFTGGLPYWDWTRPMSALPHFVADPTYDDSVSSLEEDNPYSHGHIDSVGHDTTRAVRDDLYQSPGFGHYTDIAKQVLLALEQDDFCDFEVQFEIAHNSIHALVGGNEPYGMSTLEYFLYDPIFFLHHSNTDRLWAIWQALQKYRGKPYNTANCAIVRHDTYRKPLQPFGLDSVINPDDETREHSVPRDVFNYKDDFNYEYESLNFNGLSIAQLDRELQRIKSHDRVFAGFLLHEIGQSALVKFYVCKHHVSDCDHYAGEFYILGDEAEMPFAYDRVYKYEISQALHDLDLHVGDNFHLKYEAFNLNGGSLGGVDLSQPSVIFEPAAGSHTA", "function": "Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.", "AFDB_id": "AF-P81732-F1-model_v4" }, { "swissprot_id": "Q10326", "sequence": "MSRSICTLTCILPTFSMDYWNQECVELSQVENLFTELASRLELLEMNSKNVLYRLTIGTNPDRNWEAIAFIREFFDSAKHGYVIPKHEIRNRIRLLSEASLISCLRWLLHRIPGGVITWSTYKLFDEAETRANYPVRGFDIFMKHATKHSCHFNILKCFLKLLMSLSAKLAVSSNSSTVSSLELVSQIASIWAFDWPMMNLQETFIYWDRCTNACLRLLLCYIRYTNKSSETGFSCLPSALQSQLQSFNYPPSLKKLNDAKAHVFTFSMNYYMTRDPLEMIQIVTKMNIPDHLTATLPRSSDDIQNDCLFALRQVSKRSSYHSVFSAQESAWTDFIKNGFDHPILPTCTQETVYSLLTGNDTACVYPFPNKPYRLPDVDFEIFSHCSFESLTTVTTNTNIWWVWAESRCTEIPESKRTVFPNCTMLIDKTGRLIILQQTVPQKPVALTASSNKRKNRIFGKIRRSFKRILKPRKINKTVKIMSNSQRRSCQSVLSEGNRTILLHLADQMNACSLQTKSRESIKTLKLIEEKDEYWEPETAGYFNTIVGWADQRKSLYDEAVIKINHSNMLNTLPPTSQGATSTTVSSASSNFLSSSCTPIDDTNSVTGSTLSCSFDEMKLSDKIDDANSLKDDDFIQGSKKDFFEMNLNHSSYQNKDELKPFQLLVKHAFKPPSYRLIRPPLRDWQSSDTLSSEMSKSISSSRSSPFSLEQTISKIQNKL", "function": "Has a role in meiosis and septation.", "AFDB_id": "AF-Q10326-F1-model_v4" }, { "swissprot_id": "P33202", "sequence": "MSENNSHNLDEHESHSENSDYMMDTQVEDDYDEDGHVQGEYSYYPDEDEDEHMLSSVGSFEADDGEDDDNDYHHEDDSGLLYGYHRTQNGSDEDRNEEEDGLERSHDNNEFGSNPLHLPDILETFAQRLEQRRQTSEGLGQHPVGRTLPEILSMIGGRMERSAESSARNERISKLIENTGNASEDPYIAMESLKELSENILMMNQMVVDRIIPMETLIGNIAAILSDKILREELELQMQACRCMYNLFEVCPESISIAVDEHVIPILQGKLVEISYIDLAEQVLETVEYISRVHGRDILKTGQLSIYVQFFDFLTIHAQRKAIAIVSNACSSIRTDDFKTIVEVLPTLKPIFSNATDQPILTRLVNAMYGICGALHGVDKFETLFSLDLIERIVQLVSIQDTPLENKLKCLDILTVLAMSSDVLSRELREKTDIVDMATRSFQHYSKSPNAGLHETLIYVPNSLLISISRFIVVLFPPEDERILSADKYTGNSDRGVISNQEKFDSLVQCLIPILVEIYTNAADFDVRRYVLIALLRVVSCINNSTAKAINDQLIKLIGSILAQKETASNANGTYSSEAGTLLVGGLSLLDLICKKFSELFFPSIKREGIFDLVKDLSVDFNNIDLKEDGNENISLSDEEGDLHSSIEECDEGDEEYDYEFTDMEIPDSVKPKKISIHIFRTLSLAYIKNKGVNLVNRVLSQMNVEQEAITEELHQIEGVVSILENPSTPDKTEEDWKGIWSVLKKCIFHEDFDVSGFEFTSTGLASSITKRITSSTVSHFILAKSFLEVFEDCIDRFLEILQSALTRLENFSIVDCGLHDGGGVSSLAKEIKIKLVYDGDASKDNIGTDLSSTIVSVHCIASFTSLNEFLRHRMVRMRFLNSLIPNLTSSSTEADREEEENCLDHMRKKNFDFFYDNEKVDMESTVFGVIFNTFVRRNRDLKTLWDDTHTIKFCKSLEGNNRESEAAEEANEGKKLRDFYKKREFAQVDTGSSADILTLLDFLHSCGVKSDSFINSKLSAKLARQLDEPLVVASGALPDWSLFLTRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKNKSKGSKDLRNDEALQQLGRITRRKLRISRKTIFATGLKILSKYGSSPDVLEIEYQEEAGTGLGPTLEFYSVVSKYFARKSLNMWRCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAGAFLLS", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.", "AFDB_id": "AF-P33202-F1-model_v4" }, { "swissprot_id": "B3IUN8", "sequence": "MTKQSADSNAKSGVTSEICHWASNLATDDIPSDVLERAKYLILDGIACAWVGARVPWSEKYVQATMSFEPPGACRVIGYGQKLGPVAAAMTNSAFIQATELDDYHSEAPLHSASIVLPAVFAASEVLAEQGKTISGIDVILAAIVGFESGPRIGKAIYGSDLLNNGWHCGAVYGAPAGALATGKLLGLTPDSMEDALGIACTQACGLMSAQYGGMVKRVQHGFAARNGLLGGLLAHGGYEAMKGVLERSYGGFLKMFTKGNGREPPYKEEEVVAGLGSFWHTFTIRIKLYACCGLVHGPVEAIENLQGRYPELLNRANLSNIRHVHVQLSTASNSHCGWIPEERPISSIAGQMSVAYILAVQLVDQQCLLSQFSEFDDNLERPEVWDLARKVTSSQSEEFDQDGNCLSAGRVRIEFNDGSSITESVEKPLGVKEPMPNERILHKYRTLAGSVTDESRVKEIEDLVLGLDRLTDISPLLELLNCPVKSPLV", "function": "Involved in the production of itaconic acid, a soluble unsaturated dicarboxylic acid mainly produced from sugars.", "AFDB_id": "AF-B3IUN8-F1-model_v4" }, { "swissprot_id": "Q8IZC4", "sequence": "MEGPSLRGPALRLAGLPTQQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVLHAVKNLMVCNARLMAYTSELQKLEEQIANQTGRCDVKFESKERTACKGKIAISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVVNVDKTITDICFENVTIFNEAGPDFQIKVEVYSCCTEESSITNTPKKLAKKLKTSISKATGKKISSVLQEEDDEMCLLLSSAVFGVKYNLLAHTTLTLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCRLVAQPACMAEDAFAGFLNQQQMVEGLISWRRLYCVLRGGKLYCFYSPEEIEAKVEPALVVPINKETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKRQAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQKSIKDILDPRSWLQAQV", "function": "May play an important role in lymphopoiesis.", "AFDB_id": "AF-Q8IZC4-F1-model_v4" }, { "swissprot_id": "I6YA32", "sequence": "MTPVRPPHTPDPLNLRGPLDGPRWRRAEPAQSRRPGRSRPGGAPLRYHRTGVGMSRTGHGSRPVPPATTVGLALLAAAITLWLGLVAQFGQMITGGSADGSADSTGRVPDRLAVVRVETGESLYDVAVRVAPNAPTRQVADRIRELNGLQTPALAVGQTLIAPVG", "function": "Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ.", "AFDB_id": "AF-I6YA32-F1-model_v4" }, { "swissprot_id": "Q0VFK3", "sequence": "MAFTFAAFCYMLTLVLCASLIFFIIWHIIAFDELRTDFKNPIEQGNPSRARERVKNVERICCLLRKLVVPEYCIHGLFCLMFMCAAEWVTLGLNIPLLFYHLWRYFHRPADGSEVMFDPVSIMNVDILNYCQKEAWCKLAFYLLSFFYYLYRVGATVRYVSA", "function": "Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs).", "AFDB_id": "AF-Q0VFK3-F1-model_v4" }, { "swissprot_id": "Q26327", "sequence": "EFGILEDGETIFVYVNGQMLGSSKTMPTGKERLLDISHFYFGGDNGEEKGNRHVKVRNVLLYNRVLSASELQCRLPEEVVQKPQSASPTYLKARI", "function": "Interferes with the efficient assembly of the host C3 convertase. Could protect parasites from complement-mediated lysis by sera from a number of different species.", "AFDB_id": "AF-Q26327-F1-model_v4" }, { "swissprot_id": "Q92317", "sequence": "MAGDSDNVSLPKATVQKMISEILDQDLMFTKDAREIIINSGIEFIMILSSMASEMADNEAKKTIAPEHVIKALEELEYNEFIPFLEEILLNFKGSQKVKETRDSKFKKSGLSEEELLRQQEELFRQSRSRLHHNSVSDPVKSEDSS", "function": "Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP.", "AFDB_id": "AF-Q92317-F1-model_v4" }, { "swissprot_id": "P45239", "sequence": "MKNEKLPQFQPHFLAPKYWLFWLGVAIWRSILCLPYPILRHIGHGFGWLFSHLKVGERRAAIARRNLELCFPDMPENEREVILQENLRSVGMAIIETGMAWFWSDSRIKKWSKVEGLHYLKENQKDGIVLVGVHFLTLELGARIIGLHHPGIGVYRPNDNPLLDWLQTQGRLRSNKDMLDRKDLRGMIKALRHEETIWYAPDHDYGRKNAVFVPFFAVPDTCTTTGSYYLLKSSQNSKVIPFAPLRNKDGSGYTVSISAPVDFTDLQDETAIAARMNQIVEKEIMKDITIYMWLHRRFKTRPDEKTPSLYD", "function": "Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).", "AFDB_id": "AF-P45239-F1-model_v4" }, { "swissprot_id": "Q04623", "sequence": "MLLIKRYLMDPESLRRQIMNVYKCYMWKRAFHSNRSLLEVKRREKSLQRKILERILRPKEENAVKKSGFKLWSSHLNNPHKTYMRLEELQRRIMEEVHVEGIKKNDKLFNEINQWHFQNENTSTVRTPTLLIHGYAASSMSFFRNYPGLSKHIRNLYSIDMPASGLSSVPSLEINTTTPLPLDIKFIGENKFKVPYTINANHNKFVIQMYEDFYLDRIEQWRIDNKLGKMNVVGHSFGGYLSFKYAVKYPNSVNKLCLVSPLGVERNIWSVNNNFHSNTLYTIDFKNPNSKFYSKRNMIPKYLFEQQFHILRMMGPLGAKLCWNYIMAAYSRVPSLAYKEYIFELFYGKGGIPEVTTDIFKALFSRCILAKDPLMDSLQYLNVKKLLIVYGQYDWMNKKAGMFMVKELNNLKNCLEGASYLEIPSSGHNLFLDNPESFNQSIVSFLSDETKSP", "function": "May be involved in cell wall organization and biogenesis.", "AFDB_id": "AF-Q04623-F1-model_v4" }, { "swissprot_id": "F4K265", "sequence": "MNCEVCQLKELEVESFEIREVLRCILHTIVFHRALGLIRPKDIDLELFEITYVQCGEIEVEKKIDEKIEQFINWIEKHPNKKSQICLSFYEVKSKQPSWFTKIERLYWEQWYINLNVLQPTKPPVGKSHHSKLVMDPGEASEERSSRRTLLEQSLQEVLFQIIKFVNEKKDHVPPINDGVIYYPFEITIPSSSDSAFGMDMFKRILHSGHPSMLG", "function": "Accessory protein involved in autophagy. Acts as scaffold protein of the ATG1-ATG13 complex for faithful delivery of autophagic vesicles to the vacuole. Required for selective mitophagy.", "AFDB_id": "AF-F4K265-F1-model_v4" }, { "swissprot_id": "P46962", "sequence": "MPSTFESQLFFSRPFLSKRQIQRAQKNTISDYRNYNQKKLAVFKFLSDLCVQLKFPRKTLETAVYFYQRYHLFNRFETEVCYTVATSCLTLGCKEVETIKKTNDICTLSLRLRNVVKINTDILENFKKRVFQIELRILESCSFDYRVNNYVHIDEYVIKIGRELSFDYKLCNLAWVIAYDALKLETILVIPQHSIALAILKIAYELLDNKNWSSKRYSLFETDEKSVNEAYFDIVNFYINSFDMCDLQRHLPADLLPIGVERFMELKKNAGPESGLPQIPDHLLNADPYITITRDNNVQERRYVLSLELINGESSINSSTRHA", "function": "Cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase II transcriptional elongation, and as part of the CTDK-I complex, pre-mRNA 3'-end processing and SET2 mediated H3K36 methylation. Together with CTK3, required for CTK1 CTD kinase activation. Required for DNA damage induced transcription. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus.", "AFDB_id": "AF-P46962-F1-model_v4" }, { "swissprot_id": "E7DDH2", "sequence": "MQKRMLGGMVAGALACFQVQAAQFQCQDDVKPAAISAEEQKLVDQFWAESLVYLEQYLKALETPTGQCKDSAQATIQTYHSETGKAQTRCIMKYRDMELLAKHLKAVLAEPDKAKACFDPQKNYKEFTLYTPSSQVQQLSATSTWINRPLLTDYYTKMGGAIGAAGLELNENFLAITSRTDTTAHWTRDVSIKGLPTLWSSVGWVPLYAENPAAGSDRFRGGYLYAELMGPWGNLRIKEINGEKVGAEIGMTVQLFNTSYPFHYHHPQETYMTLTKPQCVDQNKYMVMHWDSDQFTQTRSDKGWTVEIDGSKERWKKWFANQDVNKEWLTYFERNAIHAFHALEGCNQTIQNSGLVAVWARSTSQDNEQFTQLCRPASGPDGVKRMRPGQKTVCDVRDWKP", "function": "Able to cleave dimethylsulfonioproprionate (DMSP), releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere.", "AFDB_id": "AF-E7DDH2-F1-model_v4" }, { "swissprot_id": "D0NVF3", "sequence": "MHLFFLTAVAFVITSVSVDASVAKDPRGHAPNRTEVDTVNASSSTRLLRKNSTVDLVGEERAPSIVENIKALVKSSAVTPAKLQQWLDERLPAGLVFKNMNLDEPNIFSLLHEPNFAKWVQYADDLSAKSSHKESSVISTLTSLHGDKVVYDTIQAAKLYPQLSELALKLEKDQIRFWIATRKDPSVVFEALNLNWAGISIFPKPEFSAWLKYVDDVNARHPKEAPLSIIPTLKQRFSRGDEAGTDVLLKLIANGKATTEAKTVANKVESALFDFWLNSRETPDKVMDAFKYGTTTQAFLGSPRWKEWERYLSAYNARYPEKKATAIETLTRKYGDAQLLDTLIGASSKGETKTLAAKLQAQQFDRWMNLKESPLDVYNRLRSSYGDTAFFNEPQLNVWVSYMNVFVDKNPSKVDKMFLELGDTFGDMRLFRVLGEAKKFPNLESTATKLQMEKASTLFASGKSPEGIFKVLALDNVGDDILSNTLFHKWLAYLQKFNKEHPNNQESWFDMLRISYQPFGVERIIETGRKNPLTRLMAEKVENAYHNYWLDIKMEPKTAFRSLHLDESGEKLLADPKFNTWVQYLKTFNDRYPNEKTTVIDGLRDNSHDIALLRMFSAAKNDPSTEKLATDLQSALILKWQDAKKTPEELKRVFVGVPAADEMLDRYIKLLAVASSTP", "function": "Effector that enhances P.infestans colonization of Nicotiana benthamiana leaves.", "AFDB_id": "AF-D0NVF3-F1-model_v4" }, { "swissprot_id": "Q94DR2", "sequence": "MRLVGLTGGIASGKSTISNLFKASGIPVVDADIVARNVVQKGTGGWKKIVEAFGNDVLLENGEIDRARLGQIVFSDPEKRQVLNRLLAPHISSGIFWEILKLWIKGCKVIVLDIPLLFETKMDQWTHPVIVVWVNEATQIERLMSRDGCSEEQARNRINAQLALDWKKSQADIVIDNSGTLDETKEKFQEVLRNVSEPLTWKERLRSRDGLFSVVVCTAVGVLLAQKNLL", "function": "Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.", "AFDB_id": "AF-Q94DR2-F1-model_v4" }, { "swissprot_id": "Q07551", "sequence": "MSFHQQFFTLNNGNKIPAIAIIGTGTRWYKNEETDATFSNSLVEQIVYALKLPGIIHIDAAEIYRTYPEVGKALSLTEKPRNAIFLTDKYSPQIKMSDSPADGLDLALKKMGTDYVDLYLLHSPFVSKEVNGLSLEEAWKDMEQLYKSGKAKNIGVSNFAVEDLQRILKVAEVKPQVNQIEFSPFLQNQTPGIYKFCQEHDILVEAYSPLGPLQKKTAQDDSQPFFEYVKELSEKYIKSEAQIILRWVTKRGVLPVTTSSKPQRISDAQNLFSFDLTAEEVDKITELGLEHEPLRLYWNKLYGKYNYAAQKV", "function": "Reduces aromatic alpha-keto amides, aliphatic and aromatic alpha-keto esters, but not beta-keto esters.", "AFDB_id": "AF-Q07551-F1-model_v4" }, { "swissprot_id": "B9LZU3", "sequence": "MLRLYFVALQFLAIIPIPFSFRCREEDLGRSMSFFPLVGLTLGLLLAGCDYLLALALPRPVADLLLVAILALVTGALHLDGLADVCDGLAARGGRERFLAVMKDSRVGAVGVVGLVLALLLKYQALFAVTTDKWETLLFFPMVARFSQVQLTVGSKRARQDGLGSLFIGGAGSMQVAVAAFFTVVTGWLLLGLPGIGCAAVCSLFTCLAKAWFHRKLGGITGDAIGCVSELNEILCLMTLVAIGGRF", "function": "Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.", "AFDB_id": "AF-B9LZU3-F1-model_v4" }, { "swissprot_id": "O01739", "sequence": "MLYALLLLFGGVSTVSSLRVAVVGEGVIGLSTATAILDLAEKRNIPAPEIHIFHHKPFEKILSRHIAGLFRIDSGSEIDRKYGYDTFEKLATLWREYGGLSGVQLVSGHILSDSKTKLDSQRESYGSLVYNYRDLAEPELFGPTSLFDLPRNTTTRGIHYTAYTSEGLRFCPFLKKELMTKGVRFTQRRIGNLEELGAEFDVVVNSAGLLGGVLAGDDAGNMKPIRGVLIRVDAPWQKHFLYRDFSTITIPVIDHVYMGTVKQEGAFGPNNVTSADIQDITSRYVALQPSFKRVHMLSSFVGYRPGRKQVRVEKQIRETNGSKKFTVVHNYGHSGNGFTLGYGSAVHAAHIVLDLPLDAYHGLVPEPLPINATISEWVKYLDD", "function": "Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. Has no activity towards L-amino acids or N-methyl-L-aspartic acid. May play a role in the egg-laying events and maturation processes of the reproductive organs.", "AFDB_id": "AF-O01739-F1-model_v4" }, { "swissprot_id": "P41546", "sequence": "MEMTDFELTSNSQSNLAIPTNFKSTLPPRKRAKTKEEKEQRRIERILRNRRAAHQSREKKRLHLQYLERKCSLLENLLNSVNLEKLADHEDALTCSHDAFVASLDEYRDFQSTRGASLDTRASSHSSSDTFTPSPLNCTMEPATLSPKSMRDSASDQETSWELQMFKTENVPESTTLPAVDNNNLFDAVASPLADPLCDDIAGNSLPFDNSIDLDNWRNPEAQSGLNSFELNDFFITS", "function": "Transcriptional activator involved in the unfolded protein response (UPR) pathway. Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes such as KAR2, PDI1, EUG1 and FKB2. Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway.", "AFDB_id": "AF-P41546-F1-model_v4" }, { "swissprot_id": "Q96PG2", "sequence": "MKAEATVIPSRCARGLPSWQVLSPVQPWQTSAPQNTTQPKLLAPHQHEKSQKKSSLLKELGAFHITIALLHLVFGGYLASIVKNLHLVVLKSWYPFWGAASFLISGILAITMKTFSKTYLKMLCLMTNLISLFCVLSGLFVISKDLFLESPFESPIWRMYPNSTVHIQRLELALLCFTVLELFLPVPTAVTAWRGDCPSAKNDDACLVPNTPLHLKGLPVEPPPSYQSVIQGDAQHKQHQRLREVKQVAPDTWIVTDGAAIWTQTAN", "function": "May be involved in signal transduction as a component of a multimeric receptor complex.", "AFDB_id": "AF-Q96PG2-F1-model_v4" }, { "swissprot_id": "Q46508", "sequence": "MSMLTITIDGKTTSVPEGSTILDAAKTLDIDIPTLCYLNLEALSINNKAASCRVCVVEVEGRRNLAPSCATPVTDNMVVKTNSLRVLNARRTVLELLLSDHPKDCLVCAKSGECELQTLAERFGIRESPYDGGEMSHYRKDISASIIRDMDKCIMCRRCETMCNTVQTCGVLSGVNRGFTAVVAPAFEMNLADTVCTNCGQCVAVCPTGALVEHEYIWEVVEALANPDKVVIVQTAPAVRAALGEDLGVAPGTSVTGKMAAALRRLGFDHVFDTDFAADLTIMEEGSEFLDRLGKHLAGDTNVKLPILTSCCPGWVKFFEHQFPDMLDVPSTAKSPQQMFGAIAKTYYADLLGIPREKLVVVSVMPCLAKKYECARPEFSVNGNPDVDIVITTRELAKLVKRMNIDFAGLPDEDFDAPLGASTGAAPIFGVTGGVIEAALRTAYELATGETLKKVDFEDVRGMDGVKKAKVKVGDNELVIGVAHGLGNARELLKPCGAGETFHAIEVMACPGGCIGGGGQPYHHGDVELLKKRTQVLYAEDAGKPLRKSHENPYIIELYEKFLGKPLSERSHQLLHTHYFKRQRL", "function": "Catalyzes the reduction of NADP in the presence of molecular H(2) to yield NADPH.", "AFDB_id": "AF-Q46508-F1-model_v4" }, { "swissprot_id": "Q9YBS3", "sequence": "MGVFNRLRSFYEARIAPTVASFLSRISPDPNIYTLASPVAAAAALPAWLYISPVASLLLIALSLLLDAVDGAVARFTGRVSPLGSFLDSSLDRISDSLYHATLYIAGVHPLIVIAMLSGGLIVPYLRAKGESLGLEVRGRGLMERGERSIAILAILAISIYNLQTALALASAAAVLVWITVIQRMVYIAGELRR", "function": "Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.", "AFDB_id": "AF-Q9YBS3-F1-model_v4" }, { "swissprot_id": "P38958", "sequence": "MGLFNNFKFKYTRAQLEIFRFSFCLLAPVAVMYYIGTDTDKKLNVPGFWPDPATLNQIPKEPYEIKAELARMKKERLEKRLRLEKKIQEEFGLDLEEEKEKIKRDLALKKG", "function": "Required for the biogenesis of cytochrome c oxidase. Probably for its assembly into an active holoenzyme.", "AFDB_id": "AF-P38958-F1-model_v4" }, { "swissprot_id": "Q09189", "sequence": "MNVTRLYFRVAGTKQFARYVHKYAAYSSTSFQKKKSHFPSPATLDHPDAGEDAFINLRNENYILNAVFDGVGGWANVGIDPSIFSWGLVREIKKVFNNSDEFQPSPLTLLSKAYAALKKSNTVEAGSSTACLTLFNCGNGKLHSLNLGDSGFLILRNGAIHYASPAQVLQFNMPYQLAIYPRNYRSAENIGPKMGQATVHDLKDNDLVILATDGIFDNIEEKSILDIAGVVDFSSLSNVQKCLDDLAMRICRQAVLNSLDTKWESPFAKTAKSFGFKFQGGKVDDTTITCLLIKSKNYE", "function": "Confers azacytidine resistance in high copy.", "AFDB_id": "AF-Q09189-F1-model_v4" }, { "swissprot_id": "O60240", "sequence": "MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS", "function": "Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.", "AFDB_id": "AF-O60240-F1-model_v4" }, { "swissprot_id": "P17054", "sequence": "MSKNTEGMGRAVVIGAGLGGLAAAMRLGAKGYKVTVVDRLDRPGGRGSSITKGGHRFDLGPTIVTVPDRLRELWADCGRDFDKDVSLVPMEPFYTIDFPDGEKYTAYGDDAKVKAEVARISPGDVEGFRHFMWDAKARYEFGYENLGRKPMSKLWDLIKVLPTFGWLRADRSVYGHAKKMVKDDHLRFALSFHPLFIGGDPFHVTSMYILVSQLEKKFGVHYAIGGVQAIADAMAKVITDQGGEMRLNTEVDEILVSRDGKATGIRLMDGTELPAQVVVSNADAGHTYKRLLRNRDRWRWTDEKLDKKRWSMGLFVWYFGTKGTAKMWKDVGHHTVVVGPRYKEHVQDIFIKGELAEDMSLYVHRPSVTDPTAAPKGDDTFYVLSPVPNLGFDNGVDWSVEAEKYKAKVLKVIEERLLPGVAEKITEEVVFTPETFRDRYLSPLGAGFSLEPRILQSAWFRPHNASEEVDGLYLVGAGTHPGAGVPSVIGSGELVAQMIPDAPKPETPAAAAPKARTPRAKAAQ", "function": "Converts phytoene into all-trans-neurosporene as the major product, via the intermediary of phytofluene and zeta-carotene, by the introduction of three double bonds. Both intermediates, phytofluene and zeta-carotene, can be used as substrates and converted to neurosporene. 1,2-epoxy phytoene is also a suitable substrate whereas the C30 diapophytoene is not.", "AFDB_id": "AF-P17054-F1-model_v4" }, { "swissprot_id": "Q9FIK2", "sequence": "MYGRSGLDRFKKSQTSEPFSVSANPPPVVQQHLSPEALSGQKTQIGAGQSNWHPPDWAIEPRAGVYSLEVVKDGQILDRIHLDRRRHIFGRQHQTCDFVLDHQSVSRQHAAVVPHKNGSIFVIDLGSAHGTFVANERLTKDTPVELEVGQSLRFAASTRIYLLRKNSEALFSRPPPPAEIKLPPPPDASDEEAVVAYNTLLNRYGLSNGESGGMLGKRKEKTGSEAGVAKRMKKVRVSFRDQLGGELAEIVGMSDGADVETEPGPINVKEGSLVGKYESLVRVTLIPKGKVKEEKAFTGGTRGGVTDRLQEAMNMLKRGPKTGIYDDLYGGDSLAKAVGTSWASVSQPAAETECGGVGEEDDNDDLFGD", "function": "Inhibitor of protein-phosphatase 1 (PP1). Binds to and inhibits PP1 activity.", "AFDB_id": "AF-Q9FIK2-F1-model_v4" }, { "swissprot_id": "Q8SV74", "sequence": "MAISPEEILHIAYEELVEIEPMTSIPELRLLERTYPPLMPLDIARIPLYAALLLKKSNMCKIRLPSYLQLESLKMSMDVEIEKADEYSCIHPYFFPLATELLENCYNVESIEESKMIVEKIKEIRLAKTLKGIKCLDGKALNMNNITLFEFNEIKELILGSAEVGRRIEDLAKDQ", "function": "The GINS complex plays an essential role in the initiation of DNA replication.", "AFDB_id": "AF-Q8SV74-F1-model_v4" }, { "swissprot_id": "Q5SRR4", "sequence": "MRFMAGPAGSQSLGPLCFHSSPQALYTVLLIVLVMMSLVFGKFVPVNWEPPQPLPFPKYLRCYRCLLETKELGCLLGSDICLTPAGSSCITLHKKNSSGSDVMVSDCRSKEQMSDCSNTRTSPVSGFWIFSQYCFLDFCNDPQNRGLYTP", "function": "May have a role in hematopoietic cell differentiation.", "AFDB_id": "AF-Q5SRR4-F1-model_v4" }, { "swissprot_id": "O32001", "sequence": "MKKVLLGFAAFTLSLSLAACSSNDSEKVSTEKETPQASTDVEKKTEQKESTKEKTADKSKEKDKKELVDVTLDRAVDGDTIKVTYNGNVDTVRYLLIDTPETKKPNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLKEGLARVAYVYEPNTKYIDQFKKDEQEAKSEKLSIWSKNGYVTDRGFNGCVKEKTTAVKKATTSKPAATQPTTPKASSETSTTTEKEASSETTGGTETFKNCTELRKKYPNGVPSSHPAYQSKMDRDHDNYACER", "function": "Catalyzes the hydrolysis of supercoiled double and single strand DNA and RNA. Involved in chromosomal DNA degradation and cell death caused by thermal stress.", "AFDB_id": "AF-O32001-F1-model_v4" }, { "swissprot_id": "P22543", "sequence": "MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT", "function": "Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity.", "AFDB_id": "AF-P22543-F1-model_v4" }, { "swissprot_id": "Q7NQS7", "sequence": "MIRRVLLLSLALLLAGCANEALFRPKPALESAADAPFSVSGRLSANLDGKGHVANFDWRHLPPRDEVAINSPLGNTVAKVLRDPGGVTLLADGKRWQADDVESLTRQVMGWPLPLSNLVWWIRGLPAPGVESRVDADGNLEQQGWHIRFIRDADVDSDHPKRVEMQREGLTVKVVVQSWQ", "function": "Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.", "AFDB_id": "AF-Q7NQS7-F1-model_v4" }, { "swissprot_id": "Q56888", "sequence": "MLTCLSRRVLVGLFSIGILPLNAMASGSWVADDIGITQSVRGVAISAKPLQSPVALAQDNARIVSISWRYQLMSAAPDGLQVKLCTPTRCMPLEGGSGLSRGLAGEAAATQLTFIYFIAGKGRVNPPLQVINHQVIVNYR", "function": "Not essential for flagellar formation and function.", "AFDB_id": "AF-Q56888-F1-model_v4" }, { "swissprot_id": "Q59PG6", "sequence": "MTCLDELAHSLESKSDTTNFKTRNSKIKTIDLYQQNELSGKHPQDQDKFYRLPAIDPIARDKKPWKEDINYFNKCYISSLALMKMCTHAQTGGSIEIMGMLVGKISGHSIIVMDTYRLPVEGTETRVNAQNEAYTYMVEYLTERQQLSNGKNEENIVGWYHSHPGYGCWLSGIDVSTQSLNQGFQDPYLAIVVDPVKTLKQGKVEIGAFRTYPEGSQQQPSMTNKTRKDQNKPHNSGANANRKILPKSKQKDFGSHADKYYSLDIEIFTSSWDDKVIEMLKDEDSLTWMKNLLVDSNNNDKILGIRKDEIRSIELIKNYELISQGNHNADEGETIFDLIEQLKIQANTPKFMLDKLTTMKFDSTFESVLYKRLLKKTQKSTTTKKNRKDLSTDIDDETMLDESDLEKNVGTGGIETSISSDDDDEEEEGEGEGNSSSRRDNNNNEVEEGPTDEVDSEYANEELLEEVGALENYNFNDLLENKSANKFLRSEQKIKHKNRPIHQRMDNSSMISEWNRLGHQQQHMPADYPYQWSSNVANLVKTSKTNRRRERLHRLQGASIDNKKQFELGLHGSPESKAKSANLVKLAKSIGLNEVFDLITLDAQQKLFG", "function": "Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.", "AFDB_id": "AF-Q59PG6-F1-model_v4" }, { "swissprot_id": "Q9H422", "sequence": "MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM", "function": "Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).", "AFDB_id": "AF-Q9H422-F1-model_v4" }, { "swissprot_id": "Q8X229", "sequence": "MNFKTENSTTPNGDWSQSKAFTNSGSSFPVLNGTCELDQENLALSNSGQPESIFTQDSGLHGIDVAAPSDITDLNNQSGYQYNNNLAHDLYFTGSMEMPTTQHPYITNTNNHLSYSNSSEEFSPIGNNMSPDSTGGANSNNFTSGNKRKASNESFSPLSGHHYGTESGNNNNNNGTSRSSQSSSHKSRKKLLDEKDAALIARDDSELTEEELQMKRKAQNRAAQRAFRERKESKLKELEAKLLASEEERQKLLDELEQIKKQNISIATENEILKHNGMGNINNDVQIGNLSSYGRLQVDKFNFPKTQKDFIEHVLQGTNHQLKDENKDKVYNDNQGHKLLALGAVWDYLQIKAEEADLDFNSIDFNDVMEKLKGNEKCHGYGPAYPLELVNEAIESSLN", "function": "Transcription factor that confers fluconazole resistance in S.cerevisiae by activation of the PDR5 gene. Can also activate the transcription of S.cerevisiae genes involved in 4-nitroquinoline-N-oxide resistance.", "AFDB_id": "AF-Q8X229-F1-model_v4" }, { "swissprot_id": "Q9USH8", "sequence": "MKFSQWYTLTAPLLISSLYTVNAANDLRGVASDKSDLYKPDAKGNWKCLGSDKLISFNQVNDDYCDCPDGSDEPGTSACHNGKFFCKNTGYISSYIPSNRVDDTVCDCCDGSDESLIKCPNTCAQKAREYLATLEEHNRLVKNGLKIREQWALESAKKTDEVKARYKEISDSLVAVSAEKTQLSEKVEKMKRSTDLGAEAVLPLDFQDLRVALLSLVDERNEMQERLDILTNLLDELTLLYETDKFDETMKEAILSFEDLKEQEIRRKVSSDDVHNYLESCNNHLSMLTGPSEDITFSSLIKDIKKILNSLVWNIKLSLINFGILSPSASSTPLTDSESYRRFEAAQRDLDAAEENEKSLEKEHTKLMHELEYHHGWDLYRAIKGMETKREIGGYTYKVVFYENVFQDSILLGNFASQEGNVLKYENGQSCWNGPHRSAIVTVECGVENEIVSVLEAQKCEYLIKMKSPAACSPDQLKQSLLNTQNSANENAVNGMEDKESSVDEL", "function": "Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER). Specifically required for the cleavage of the final glucose. The subunit beta retains the catalytic subunit alpha in the ER.", "AFDB_id": "AF-Q9USH8-F1-model_v4" }, { "swissprot_id": "B0R4J5", "sequence": "MTDFQTLLEFIETETGFATSYYDESYLDRRVSARMRRRGVEEYAGYLTLLEEDDDDERAELLDTLSVNVTEFFRDEKVWTALRDVLLELADTVRSIDIWSAACADGREPYSLAMLALDAGLDPRNVSILATDIDEDALARARAGRYESTRTADISDQLGFLDNPQEYVDREGDRAFVVNDRVKDLVTFERHDLITGDPKSGFDLVACRNVCIYIDKQYKLPILDTVSKSLREGGHLVLGQTETLPGEVKERFEAEDPRIRIYSRVADT", "function": "Catalyzes the methylation of several Htr transducer proteins (methyl-accepting chemotaxis proteins) to form gamma-glutamyl methyl ester residues.", "AFDB_id": "AF-B0R4J5-F1-model_v4" }, { "swissprot_id": "Q6AXK4", "sequence": "METTEPGQADGEERMMDLRPRTRSNPEGAEDRRSSTGSLNSSLPSAPQPAVGSRVEGEGEAASSDSPPVSATAIAATASVPVAAVGNTTTTNTASLPAMSPAVKERPKPSQPTMPTQIPPSAELHLRAPRVNCPEKVIICLDLSEEMSLQKLESINGSKTNALNISQKMIEMFVRTKHKIDKRHEFALVVVNDDAMWLSGFTSDPRELCSCLYDLETNVCESFNLEDLFNVILQKIELPQMENIQTIPPPFVVRTLLVFSRHAGMLQFNPSDAVKKMLQSPYFFFDVVFLHNGTEEQTEDTSWKDVYASFCELDTKGMCYRFEVSLCGPAIELHNCMAKLLCHPLQRPFQSHASYSLLEDEDTLENEATV", "function": "Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of babam2 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3/brcc36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.", "AFDB_id": "AF-Q6AXK4-F1-model_v4" }, { "swissprot_id": "Q3UTQ8", "sequence": "MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVESSTLSNRNQSTKGAALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDTKPSEGPGTKYLKSSTRSQQNRHSFMESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETNTSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARPSVKESSREGASSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHADQLKEKEKQGFFRSMKKKKKKTQTVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQQAKNSFSEIRIHPLSQATGGSSNIRQEPTPKGRPALQLPGSSLLRYNGWKHSRSRSSQPDEVIFLASHEKWKQ", "function": "Mediates phosphorylation of MECP2. May regulate ciliogenesis.", "AFDB_id": "AF-Q3UTQ8-F1-model_v4" }, { "swissprot_id": "Q9UTK1", "sequence": "MLFYRFKSWYRLQAKKSPFIYVGLPFLSSVLLVWSCLIPISQVKFNRRDEQVKSLSRDAELDIIKRRRKVDVNEEYYRILLDQLNLQNEEYENKRVKRLKGEPTWEGNSSDKE", "function": "Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.", "AFDB_id": "AF-Q9UTK1-F1-model_v4" }, { "swissprot_id": "P21711", "sequence": "MDGFSQQLEDLYPSCFSPCPSPLGFSEPVIQPFAMNLAPAAQKDFQQHPNRREVTKIPGAGEQSPVQNVRPKDAINPKEADPRSPTADASLVPASQRRKRTFFTQAQLDILEQFFQTNMYPDIHHREELARHIYIPESRIQVWFQNRRAKVRRQGAKATKPILAGHHYSGTSGANRAMFPSAPAPNSSSHQMTTSRAQVQPLKESQMNMFHQNQGFLPYPDSSCNVSRQRFLMSQPTPGAYHLPQASSNVYNQNVKSQNPLWNQQTTNRVYTNMMETVLDLSRRPSQQMPVQPMLMNSFQTNKNIKPEVYTTSPQIPVSTTSSQVSLFANQEPCHMSTTQGGTYGQISPISDSGVSDTSPEPSSDWEENVASVLLNL", "function": "Transcription factor which plays a regulatory role in the development of the embryo. Involved in the establishment of dorsal/ventral pattern in the early mesoderm. Activates the head organizer gene cer1 by acting synergistically with otx2 and siamois through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and siamois to the 3x 5'-TAAT-3' element of the cer1 promoter.", "AFDB_id": "AF-P21711-F1-model_v4" }, { "swissprot_id": "P35783", "sequence": "NNYCKIKCLKGGVHTACKYGSLKPNCGNKVVVSYGLTKQEKQDILKEHNDFRQKIARGLETRGNPGPQPPAKNMKNLVWNDELAYVAQVWANQCQYGHDTCRDIAKYQVGQNVALTGSTAAKYDDPVKLVKMWEDEVKDYNPKKKFSGNNFLKTGHYTQMVWANTKEVGCGSIKFIQEKWHKHYLVCNYGPSGNFQNEELYQTK", "function": "May have an ancestral function in the promotion of ovum fertilization by sperm.", "AFDB_id": "AF-P35783-F1-model_v4" }, { "swissprot_id": "O31945", "sequence": "MKGKKDGLNKQVHIYSIDTSAFYNDQENKLHNKILKSYRYRDHLRKLEHVDKKHKKYITQRIISLKEKLYNAFNDHNQIRTLRTDSLKDNNVISLFDSVLTRTLGIKENSLSEEIMVVQTYHFQILRDIIDKGFIHNNEKYVYFTSSAGQIRTKKSCFIKQSTLDKYQNALTCGLSVEHINAQGGSSINKWNSYMALSNSASSSWEIDIDKAIVVNDLETNVSSLVDYIDRDTYEITRKIMDIPIEHTDGCGMMLPSLSQKSFMVRLPWVKGLLVPFDFRKFAEKHSSFIVKDVYGKEWDIIKDDIQIIFTKSQFKMWKYYDSWDDYRYKFKKYGCLGAKLNEEDPSVEGKLTYQMLQTLTDITDEELKQISSKTVSEITQLGTDKETMMKVLGATEKNKHKTSLQEALLIYPELLNDDHTKEIIKNKKKSMIKDAKSGKLLVSDARYTYLCPDLYAFCERLFLGIESPKGLLSGSDVHCSLYDEGYIDILRSPHLFREHGVRWNKKNEEYEKWFITPGVYTSIHDPISKLLQFDNDGDKALIISDELIVNIAKRNMADIVPLYYEMSVAQKQEINSRNIYEALTLAYGINIGEYSNNITKIWNSDNINLDVIKWLCMENNFTIDFAKTLFMPTRPDHVDEKIKDYIKNKVPHFFINAKDKEEHSVESINESTVNKLDSIIPSDRINFAAVAGKFDYRFLLKNKEIKLNEAVINEYKRLDRNKKWLMNDEEAKPGQKLYVYKIIKQKLLEIHNDDGFITDVLVKHLYKKKSKYKSTLWECFGDIVLENIKHNLKTFKGCCICGKAFKPTSNKAKYCQSCGKKKERDKYKKYNKKRINHR", "function": "A single subunit DNA-dependent RNA polymerase (RNAP) that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates (rNTPs) as substrates. The enzyme is more highly processive than the multisubunit RNAP from E.coli but is considerably more error-prone. It has no detectable proof-reading function but can perform pyrophosphorolysis. Transcribes the late genes of the SPbeta prophage starting from yonK (approximately 35 genes are encoded in the prophage downstream from yonK).", "AFDB_id": "AF-O31945-F1-model_v4" }, { "swissprot_id": "Q7NI47", "sequence": "MTFGHCRRASTLRSAFVLGLCGLLLAGCSGADDDRDAAALKDKYVTVNLGVRGPVDLPADGVGNLQTFSPQQIYAGKKLFESNCQNCHVGGTTTPNPKVSLALAKLQGATPPRDNIQSLVQYMRLPMSYDGSEETFNCRKSDWIEDDEAQNLAAFILRASQKARGWGTARLEANQDSMTTAPP", "function": "Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II.", "AFDB_id": "AF-Q7NI47-F1-model_v4" }, { "swissprot_id": "P45400", "sequence": "MLFWILVAILTAAVAAVLLLPLMRAAEPLPSRHSHDIEVYRDQLGELARDREAGLIGSEEAELARAEIARRMLSASAADQAVAERTPKRLLSNRLAQAFIFLCLPAVGLCLYLTTGSPGVPAQPLAARLADPGDDVNILIAKAENHLALNPQDGAGWDLLAPIYMRHGRLDDAVAAYDRAIRLLGPTPARMGGYAEALVAQAGGLVTAEAQNALQKALALDPDDPRSAFYLALGLKQEGKHAEALAAFRKLAESSPADAPWLSLVNQHIAELAAAPAGPGPAAPGDPAPGDIAAAKEMNAGDRQAMIRGMVDSLASRLKEDPANLEGWMRLVRSYVVLDQRDRAKDALHDGLRAFPATGEQGKQLLALARELGIDAGGEAE", "function": "Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.", "AFDB_id": "AF-P45400-F1-model_v4" }, { "swissprot_id": "Q49ZI7", "sequence": "MKAIILAGGQSERFGEPKAFAQINAQPFYKRIIDVLEGTNMFNQIIISTNETLASQFDHSDIIIDEDQNKDKGPLAGIQSVIQHYESEELFFVVSVDTPMISQKAVSKLYQFMVEHLIEDQLDIAGFKEKGRPIPTIAFYSPHTLPYIDDALNSNDYSLKSVYNKVKSDWLDVNLIESPDYWYKNINYQQDLDSLQQDILNR", "function": "Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.", "AFDB_id": "AF-Q49ZI7-F1-model_v4" }, { "swissprot_id": "Q07065", "sequence": "MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV", "function": "High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.", "AFDB_id": "AF-Q07065-F1-model_v4" }, { "swissprot_id": "Q0IEK6", "sequence": "MVPLSGEQLAQFYRVDGEMALAEAFEKEFLTRELQENDQCMNHPLYQLLQRYAKARAEFSLNVLEFEALRRKCKALANELWTVREQTFAGTGTCGDGKVVHASHISSVAALQESALADFSSNLQDLMKQSFFQCSQSTYEVDATRIKIEQKIYETLNLHPVLSNLPADSPVVLNPPIDAMQLTAAIGELRLCISILFAFLRKGITDKRFLADVRGWTVKLVATQLRIATVHDHLFVLFHVLRSPSGIANWATSLVQLPTEQDLRWGSSEFQHILVVMACILLPIKKRNEFLEKLKLDMNRSIDVVQEEMWAIVDSDGEDCSGSDSISELKEGDLVALIDQIPFGMVFRALTLVDRKLDGTWRLGEDQVRGTHVMKAIAFGTIFVELLGNGLMTYNADRYRQFAKRVARLIKHTVYYVSDLYRILLERTRSVQVVLDDYETTRINLELDVFVVRAAQYIYRSRKIGTWQYLSGFPFDQLSVGALWKLYYFLHLDEFNEELITAVGTDFRDLCIGPNQREKFRNGLVGMPSEDLYYLLQVFSNMALAREIDDFEFIETVALNLFDIGYLNEYTKDFCYKAVKDLLFNIVYKHPSLVSSLLQYMKQDVAQADHSALYVFKSLPLDRWRPQWDDFELLANWILNYGFDAVQSSTARVILIHLNYNFDSNNELFLPHDIHVRIACLITEIYSKHVPELLGNPQGLVASVSSLVKNKTAQDQFLAWCWNMVSLLRLHCMDQSPTVINGMMKNPALILRYVLELERAQQIYQGVTENRPLAIYLAILISTWGHSVPQICHQGFEQIRLLLNDHRYVVVVRCLQLITPLFLECPDSLSHCESFKSILISLMAADKYYARFTKDQFKPESNSPCLTELPNWTKDPAIIGLLDAMAGVAYQFPDAWHSMKEFFRPYFSVSSIILHSPSSATVFLSIFTLELEYELTEIQSGIWHEVIRGIGLPSSPKLTIETAIKKSTSILGYPSFPPSSLAVFKLANLVANCTIKNFMYPIVCQLFFTIYLSRLPLSTEEQRFANCFGVSDQIYECNVGLMKRIKKQLYDAECFYNSASVSESDERQRSFYNHCTRLFKTFQLWLEDTQLNKISTNAVNLPPQFDRYRLAAIFRGNRDHWTDFIDFRGIRSDHRDLADAWQKLCYRYKPEVSTVATNSPARSLASSHSVTDLQDFKQSIFKRLETYDAPAPAPLVFKPTPLIPPAKFTTQSSNSFLVMYNEHLLLDSFYLEQVPKLYIVEDKVLYKDASCSNGCTESRKVLVRYKVSKLDKNLSAVLRENRSAHEALLQRESKLPDRIVMASVRIDAFLRQIVEAYREFKLSGETNVCAKLNKVGSTLFYEFVGKMNDYNQLCPLTKDVCSLGISQLGFFMRENQNDEGIKLLNITLGRPEMISLLSELLVPASCPPQFFLRMYEFVIDSHIKRHDTQVLFVMLSKFDIIAWMNRYRPKLVDVRRLVELILRGLEGWTQKNAVLIQDLLQRHLMHLFEFDFPEYYGDILQMVLAACSLKKIMAQVLLELLNSMRRRVECQPLTFGLGLVSIKEDFRSFATKQKILSYKDLIDTTVLLTQHFQQERLNHGLHGLYPVHSDYCEVLSLLLGSVGHATVVAAVHAYPGVLADELINWLWPPLCDMFSPWLTPYFPQNMKGQQQVANWIQQVASDSSILPPWSELHSETAFRMVKVFEHCIQYLMDTFPSSSALLGHLFSWYELNFAHPALPRHVAVPIHTNLMNLAWDRFRPAPVHITGFSRILQQFIPEAHKFVGHIFIRIAWTPWLQQNIQSWDYQLRYQMLSALLMIFIKISYEPNAREGLKIVTLLQEACNYPWHMLEYQGVEAVLDWFVLSAEPSVVLKMPSESEVVDSAVLDLLQVASSMKFNSGNPLESTALQSQVQAKRILYVRTTVRLLNSCGAKYQKLLGTKQGVQAFHNAVLGLFNIVETVLLQIRSTKDREFEARNLIGEVIVSLQSQGEYTSKLFTEAIVLWTENCRTSDSYIVPSVLDAVGMCKSFSLNLYLLLEEMLFHYFGKSWHGQVNDGGDPVLDASWVKALHKVGLQTVKGFDEEMLVKHRCLLVLHLLTVQKLRTAGSSGERIVVLQKLFQLLENVKVSDQTESKLILLWSLMAVVGVEIMKASSNGQNHLLTLARYLQTCSKDAEGWGEGLLGAIGIRKDGISIRRKVVAKCLSCIVFLLFGEDSGEALEASESGPPSIDCANRCKEYDQAMGDLKQTLTNKRYGDMHIKTRAAINLVENTAMIANIGENVCKIVRLFCDEHFFHSVEEVWRC", "function": "Involved in autophagy.", "AFDB_id": "AF-Q0IEK6-F1-model_v4" }, { "swissprot_id": "Q9SG92", "sequence": "MAEENQEETLELKPSRKPPHFVLIHGMSLGSWCWYKIKCLMEVSGFTVTCIDLKSSGIDSSSVDSLTTFDQYNQPLIDFLSSFPEQEQVILVGHSAGGLSLTSAIQRFPKKICLAVFIGASMLKNGLQTDEDMKDGVPDLSEHGDVYELGFGLGPENPPTSAIIKPEYRRKLLYHMSPQQECSLAALMMRPAPILALTTAKLEEEEKEKGQEEQVPRVYIKTLLDRVMKPEQQDAMIRRWPPSQVYELESDHSPFFSNPFVLFGLLIKAAVSVGSI", "function": "Methylesterase that efficiently and specifically hydrolyzes methyl indole-3-acetic acid (MeIAA) to IAA (auxin). MeIAA is believed to be an inactive form of auxin that needs to be demethylated to exert a biological effect.", "AFDB_id": "AF-Q9SG92-F1-model_v4" }, { "swissprot_id": "Q55BI3", "sequence": "MSLISIRIRSKTGVENIKLESQLKLKELQNIIEEKTKISTDTQKILYGFPPKALDLSNQDAVISGFLANGDTITIENVSSISSNPGVDSVTNDKVTSSTNSFDRNIKSQPFISQEEEEDGGYATRRVTDDDNSCLFSAVAYVLEDKNRLKGYSLRALIAQNVKSDPFEYNEAVLGKSNEGYCNWIQNPKNWGGAIELSILSNHYKVEIAAFDISTQLMYCYGEDRKYTERVYLIYDGIHYDALSICLTKNGPEDFDITRFSVDDKDSLAKMKVLIEKEFKAGKFTDTAKFSLICLNCNKTLKGEKEAAIHASTTGHGNFTEYKKR", "function": "Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.", "AFDB_id": "AF-Q55BI3-F1-model_v4" }, { "swissprot_id": "P75748", "sequence": "MSAGKGLLLVICLLFLPLKSAMALNCYFGTSGGAVEKSEAIQPFAVPGNAKPGDKIWESDDIKIPVYCDNNTNGNFESEHVYAWVNPYPGVQDRYYQLGVTYNGVDYDASLGKSRIDTNQCIDSKNIDIYTPEQIIAMGWQNKICSGDPANIHMSRTFLARMRLYVKIREMPPHDYQSTLSDYIVVQFDGAGSVNEDPTAQNLKYHITGLENIRVLDCSVNFSISPETQVIDFGKFNLLDIRRHTMSKTFSIKTTKSQNDQCTDGFKVSSSFYTEETLVEEDKALLIGNGLKLRLLDENASPYTFNKYAEYADFTSDMLVYEKTYTAELSSIPGTPIEAGPFDTVVLFKINYN", "function": "May be involved in a fimbrial system chaperoned by YbgP and exported by YbgQ.", "AFDB_id": "AF-P75748-F1-model_v4" }, { "swissprot_id": "Q62009", "sequence": "MVPLLPLYALLLLFLCDINPANANSYYDKVLAHSRIRGRDQGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWENLDSDIRRGLENNVNVELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLTQIGTSIQDFLEAEDDLSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKVVEPKIKVIQGSLQPIIKTEGPAMTKIQIEGDPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKQTREERIITGPEIKYTRISTGGGETGETLQKFLQKEVSKVTKFIEGGDGHLFEDEEIKRLLQGDTPAKKIPANKRVQGPRRRSREGRSQ", "function": "Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX.", "AFDB_id": "AF-Q62009-F1-model_v4" }, { "swissprot_id": "C3K630", "sequence": "MEFIEKIREGYAAFGAYQTWYRVTGDLSSGRTPLVVIHGGPGCTHDYVDAFKDVAASGHAVIHYDQLGNGRSTHLPDKDPSFWTVGLFLEELNNLLDHLQISDNYAILGQSWGGMLGSEHAILQPKGLRAFIPANSPTCMRTWVSEANRLRKLLPEGVHETLLKHEAAGTYQDPEYLAASRVFYDHHVCRVNPWPEEVARTFAQVDADPTVYHAMSGPTEFHVIGSLKDWKSIGRLSAINVPTLVISGRHDEATPLVVKPFLDEIADVRWALFEDSSHMPHVEERQACMGTVVKFLDEVCSVPHNVLKAG", "function": "Hydrolyzes L-prolinamide, L-proline-p-nitroanilide, L-alaninamide, L-methioninamide, piperidine-2-carboxamide and piperazine-2-carboxamide. Has a much lower activity towards piperazine-2-tert-butylcarboxamide. Does not hydrolyze dipeptides and D-prolinamide.", "AFDB_id": "AF-C3K630-F1-model_v4" }, { "swissprot_id": "Q9EP73", "sequence": "MRIFAGIIFTACCHLLRAFTITAPKDLYVVEYGSNVTMECRFPVERELDLLALVVYWEKEDEQVIQFVAGEEDLKPQHSNFRGRASLPKDQLLKGNAALQITDVKLQDAGVYCCIISYGGADYKRITLKVNAPYRKINQRISVDPATSEHELICQAEGYPEAEVIWTNSDHQPVSGKRSVTTSRTEGMLLNVTSSLRVNATANDVFYCTFWRSQPGQNHTAELIIPELPATHPPQNRTHWVLLGSILLFLIVVSTVLLFLRKQVRMLDVEKCGVEDTSSKNRNDTQFEET", "function": "The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.", "AFDB_id": "AF-Q9EP73-F1-model_v4" }, { "swissprot_id": "Q43272", "sequence": "MALAGTGVFAEILDGEVYRYYADGEWRTSASGKSVAIVNPTTRKTQYRVQACTQEEVNKAMDAAKVAQKAWARTPLWKRADVLHKAAAILKEHKAPIAECLVKEIAKPAKDAVSEVVRSGDLVSYTAEEGVRILGEGKLVVSDSFPGNERNKYCLSSKIPLGVVLAIPPFNYPANLAGSKIGPALIAGNALVLKPPTQGAVAALHMVHCFHLAGFPKGLISCVTGKGSEIGDFLTMHPGVNCISFTGGDTGIAISKKAGMVPLQMELGGKDACIVLEDADLDLVSANIVKGGFSYSGQRCTAVKVVLIMESIADAVVQKVNAKLAKLKVGPPEDDSDITPVVTESSANFIEGLVMDAKEKGATFCQEYRREGNLIWPLLLDHVRPDMRIAWEEPFGPVLPVIRINSVEEGIHHCNASNFGLQGCIFTRDINKAILISDAMETGTVQINSAPARGPDHFSFQGLKDSGIGSQGITNSINMMTKVKSTVINLPSPSYTMG", "function": "Important as a means of generating NADPH for biosynthetic reactions.", "AFDB_id": "AF-Q43272-F1-model_v4" }, { "swissprot_id": "O29976", "sequence": "MILPCESFNGVPSGCLIIEMNWYSVLKASTAIFFPEKYSSSTSSLSKRSPISAPMINVDGEYLKIFAGRIKLMKAVILAAGLGTRLGGVPKPLVRVGGCEIILRTMKLLSPHVSEFIIVASRYADDIDAFLKDKGFNYKIVRHDRPEKGNGYSLLVAKNHVEDRFILTMGDHVYSQQFIEKAVRGEGVIADREPRFVDIGEATKIRVEDGRVAKIGKDLREFDCVDTGFFVLDDSIFEHAEKLRDREEIPLSEIVKLARLPVTYVDGELWMDVDTKEDVRRANRALVSAAVKGSGDGFISRKINRKISTRISAAIVNKVNPNQMTLISFLVGAFSALASFFSIPLAGLLYQFSSILDGCDGEIARASLKMSKKGGYVDSILDRFVDFLFLAIIALLYPKTATVAMFAIFGSVMVSYTSEKYKAEFGESIFGKFRVLNYIPGKRDERIFLIMIFCLLSAISLQWIFWMFLFVAAISLTRVVVTLLAVLVSK", "function": "Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate. The cytidylyltransferase is absolutely specific for CTP and L-myo-inositol-1-P. The DIPP synthase uses only L-myoinositol-1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myoinositol, are recognized as alcohol donors.", "AFDB_id": "AF-O29976-F1-model_v4" }, { "swissprot_id": "Q8GYM3", "sequence": "MVKALQGAAQNLPADVNQLIDQLERHCLAPDGSLVTKSVYSDLQLAREEMSRERLRYLEAMAIYCEAVAMVEEYQQAISVANHGGIRDVQGLYPQLGLKNSPQVYETLEHRLVVAEAAQKLRLPLISDGGEIHEEEIEKWSILSRSSLDSASTSFTISSTSNSVNYANSSANSVAGGISLSAVDTDVVGGVPNRFLGITPAYLSYVQLQNTISMDMADYQMFLAREIEGRLKEKCDKLADAIVDDTDSSTGNRNSSARLPERVKFIIEEIERDEAALREDLYSADRKFAEYYNVLEQILGVLIKLVKDLKLEHQHKYNEMQKTWLCKRCETMNAKLRVLENVLLLETYTPDSISALHNIRNYLVEATEEASAAYNKAVTRLREYQGVDPHFDTIARQYHDIVKKLENMQWTIHQVEMDLKSHD", "function": "Involved in microtubules reorganization during spindle and phragmoplast development.", "AFDB_id": "AF-Q8GYM3-F1-model_v4" }, { "swissprot_id": "Q99335", "sequence": "MYIKLDIQTEFEVKSLSDLPNFKKLMGNLKMKINKSQLARELNVDRRTIDKYLNGFTPKGTKNKTSKIDTYYEVIAALLSSDSKQIFYYKRVLWQYLTDNHGLKCSQSAFRAYINRKPEFRTYFDEGKRILSGHSVGVRYETPPGEQAQLDWKESIRFETKSGEIVYVNVAVLLLSYSRFKVFHLNISKSQSVLMSFMTEAFEMFGGVPKVIVTDNMKTVMDEARTEHFTGTINNKFAQFAQDFGFKVQPCIAGRPNTKGKVEAPMKLLDEIHTYQGRFTFEELHEFVQKLCARINQTFHQGTGKIPVFALKQEKNLLQPLPKSAIRDSYMIKHKLVKVNTSGMISYKSNQYSVPAEYQGKTVGLQVYDNQIYVYHNMKLIVQHKISQSKLNYKEEHYKKALAKSLPKYPNIDNLAKQNLSVIGEVYRNEE", "function": "Involved in the transposition of the insertion sequence.", "AFDB_id": "AF-Q99335-F1-model_v4" }, { "swissprot_id": "P53244", "sequence": "MFSLSSLSSSGGHSEQKERERISYFDIRINSPYKDIILIQGSPLELSSIPLSGNLVISVKNEIVVKKISLRLVGRFKLEFLQVGRYKKNSSSLASLVKEKRKIFECYWDNLLVSSKGDVLVGGENAENQHNSSSGRSTSNQDMDTSGNAIFLSKRSLSSPVFNKIIRRKTHSSHRKILELPENGVTGTPFEGLRENARSRSSSSNTLNNNSHSYSNRDGSGSSYLFLMKRGNYELPFNTMLPPEVCETIEGLQSGSILYSFEAIIDGRQLWDTDLSVHTSPHGPIGSTSTSGNGMRTKNKIIIKKFKYLRILRTLSMDNLAMQEEISVGNTWRDKLQYETSIPSRAVPIGSTTPVKIKIFPFEKNIRLDRIEMALIQYYAMKDSSAQIYDDEIAVMKITHLADFGPLTDKLDVDCPFTIPDNLKQITQDCCLQDNLIRVMHKLQVRILLQRQVDGEYKNLEIKAQLPMLLFISPHLPMKGRLVLFDKHDGKIHFRPGELVPLFLTTYPAQGLTPGVELNSTTTAHLALPQPPPNYHESTNDHLMPALQPLGADSVVLTVPSYEQAQAQASASSYVTGSVPAYCDDD", "function": "May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.", "AFDB_id": "AF-P53244-F1-model_v4" }, { "swissprot_id": "P43243", "sequence": "MSKSFQQSSLSRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGRMNQGTARLASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHRGDADQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGRDGRSATREPPYRVPRDDWEEKRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMDYEDDRLRDGERCRDDSFFGETSHNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIYPEWNPDNDTGHTMGDPFMLQQSTNPAPGILGPPPPSFHLGGPAVGPRGNLGAGNGNLQGPRHMQKGRVETSRVVHIMDFQRGKNLRYQLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKRIKKPEGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDKKSKTDGSQKTESSTEGKEQEEKSGEDGEKDTKDDQTEQEPNMLLESEDELLVDEEEAAALLESGSSVGDETDLANLGDVASDGKKEPSDKAVKKDGSASAAAKKKLKKVDKIEELDQENEAALENGIKNEENTEPGAESSENADDPNKDTSENADGQSDENKDDYTIPDEYRIGPYQPNVPVGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAEERRQKKET", "function": "May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins.", "AFDB_id": "AF-P43243-F1-model_v4" }, { "swissprot_id": "Q86IV5", "sequence": "MNKLFSLILALFLVNSAVVSSLDSCSICVDFVGNSLNDLLNIILNSGVIGTCGDLCSAVPGGQIVDTVCDLLCDYVGVDEFIKLISDVDPDPIYICEKISVCKTNDNAAASLDLVQINPQNGTVGGTFTLSIAYTVTNTIATGQLAFNIIDPTGNAFGDAVLLVQQSPEQYTQQFQFQATPSEQESFPNGLYTVQALVCEGSCGSPHPNTYTLANGTTTFTISGADSSSMSGAGSFSGSSQSTQTGAASGSGSGFALF", "function": "Cell-counting factor that limits the maximum size of the multicellular structure. May down-regulate the expression of gp24, which mediates cell adhesion.", "AFDB_id": "AF-Q86IV5-F1-model_v4" }, { "swissprot_id": "Q766C2", "sequence": "MASPLYSVVLGLAIVSAIVAPTSSTSRGTLLHHGQKRPQPGLRVDLEQVDSGKNLTKYELIKRAIKRGERRMRSINAMLQSSSGIETPVYAGDGEYLMNVAIGTPDSSFSAIMDTGSDLIWTQCEPCTQCFSQPTPIFNPQDSSSFSTLPCESQYCQDLPSETCNNNECQYTYGYGDGSTTQGYMATETFTFETSSVPNIAFGCGEDNQGFGQGNGAGLIGMGWGPLSLPSQLGVGQFSYCMTSYGSSSPSTLALGSAASGVPEGSPSTTLIHSSLNPTYYYITLQGITVGGDNLGIPSSTFQLQDDGTGGMIIDSGTTLTYLPQDAYNAVAQAFTDQINLPTVDESSSGLSTCFQQPSDGSTVQVPEISMQFDGGVLNLGEQNILISPAEGVICLAMGSSSQLGISIFGNIQQQETQVLYDLQNLAVSFVPTQCGAS", "function": "Extracellular proteinase found in the pitcher fluid of carnivorous plants. Digest prey for nitrogen uptake.", "AFDB_id": "AF-Q766C2-F1-model_v4" }, { "swissprot_id": "B1NF18", "sequence": "MAPINIEGNDFWMIACTVIIVFALVKFMFSKISFYQSANTTEWPAGPKTLPIIGNLHQLGGGVPLQVALANLAKVYGGAFTIWIGSWVPMIVISDIDNAREVLVNKSADYSARDVPDILKIITANGKNIADCDSGPFWHNLKKGLQSCINPSNVMSLSRLQEKDMQNLIKSMQERASQHNGIIKPLDHAKEASMRLLSRVIFGHDFSNEDLVIGVKDALDEMVRISGLASLADAFKIAKYLPSQRKNIRDMYATRDRVYNLIQPHIVPNLPANSFLYFLTSQDYSDEIIYSMVLEIFGLGVDSTAATAVWALSFLVGEQEIQEKLYREINNRTGGQRPVKVVDLKELPYLQAVMKETLRMKPIAPLAVPHVAAKDTTFKGRRIVKGTKVMVNLYAIHHDPNVFPAPYKFMPERFLKDVNSDGRFGDINTMESSLIPFGAGMRICGGVELAKQMVAFALASMVNEFKWDCVSEGKLPDLSEAISFILYMKNPLEAKITPRTKPFRQ", "function": "Catalyzes the formation of the morphinan alkaloid salutaridine by intramolecular phenol oxidation of (R)-reticuline without the incorporation of oxygen into the product. Can also use (R)-norreticuline as substrate.", "AFDB_id": "AF-B1NF18-F1-model_v4" }, { "swissprot_id": "Q22706", "sequence": "MEENAQARERLPPTVTGLSPTEGVPGTQITIRGENLGNDQSDVIMLFICGIDSLWSMKWKSPSKIIARVGAASRGPGEVRIATKSGGKGSSNVKFRVFITQIGPLEESAVWVDETRTVPGREAIRSVPQIQDERDALGLLPSQKRMDQVLLSRDFPDCSGNLRMENFSPQWYLLENHADATIEDLRIAIKNMELSKQNEAKRSEEMHKANLYSLINCVDTLANLHQALEKGENADHFAALKNISKLIKDSKSKAENVFADVLKRKDDADATRNALGVIVRFKFIFFLSSKIEDSMKKGEYITILNDYTRAKSLYADTDVPLFRELMTEIDEKMQVFKEEMKRKLIDTPVSYEEQSKLIKYLKILDPESDPTWDCITSYYVWLEKSLWDMQTQFLEKAKLEDLENQQRINSQNHLITKTNELQNFVTTLVELLLSKLPSFWKLANTYHNSTASPDAIQRLEDINQMLTNIINVSSWLILNALVPKALPDMVLKQYGDQFAKWPTVPADISRSNLQLSLKTTRSLISSLLENQFSLTHVQPLVELCMTARLKLLSDFVDCGVERVALLAHRINWKQDILDRAQQTKTILPDYYENEICECLTRTRDALSISGYPGEACLFSRERFRDTIIDLFVHLITSIKICFDRLFIRQRPQQLAQEPGQKKGNNEITTKKLLIAVGDIEFIIAKTLNNVGKKMQECGVKHVDQIQEKSRAKLSAFRTKMINDCIAMMSSAFEPLIASATYEYLPDDDDISDYAKEMILCSVLQQAELELYAPQLAIECLQQTVSNALDALLLHFSRLNQDTSPLIVTQIVIDLTGLEEALSTYATLAIRVQINTYRAGLVGRFDNQRLQQCLKNMRTTMRMALQSLEQHAENLGDDSHNTSNI", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.", "AFDB_id": "AF-Q22706-F1-model_v4" }, { "swissprot_id": "P9WQG3", "sequence": "MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSELWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSPAINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSPERQFQVFLDDVRLPADALVGAEDAAIAQLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY", "function": "Has acyl-CoA dehydrogenase activity on a number of substrates. N-octanoyl-CoA is the best tested, but n-lauroyl-CoA, n-palmitoyl-CoA and isovaleryl-CoA were also used.", "AFDB_id": "AF-P9WQG3-F1-model_v4" }, { "swissprot_id": "Q9LEW0", "sequence": "MSARISFLKNPDPCNHLSDYKLRYGTDGYKSFNNLFRCFNDARIKIKLQGIDIPRCSYCSVYQKRLYICLICRSISCSSHILLHTQLNKGHDIAIDVERSELYCCACIDQVYDSEFDEVVVSKQLFGLGMSVKSGADVVAVRSNKKRRLDSQLIIGSNFLVSPRDRREKWTFPLGLRGLNNLGSTCFMNAVLQALVHAPPLRNFWLSGQHNRDLCPRRTMGLLCLPCDLDVIFSAMFSGDRTPYSPAHLLYSWWQHSTNLATYEQQDSHEFFISLLDRIHENEGKSKCLYQDNEECQCITHKAFSGLLRSDVTCTTCGSTSTTYDPFIDISLTLDSMNGFSPADCRKNRYSGGPSVNAIMPTLSGCLDFFTRSEKLGPDQKLNCQSCGEKRESSKQMSIRRLPLLLCLHVKRFEHSLTRKTSRKIDSYLQYPFRLNMSPYLSSSIIGKRFGNRIFAFDGEGEYDSSSSSSPSAEFEIFAVVTHKGMLESGHYVTYLRLKGLWYRCDDAWINEVEEEVVRGCECYMLFYAQETVIQKAHKELSYQVISMADAFPFADC", "function": "Component of a deubiquitination module (DUB module) that specifically deubiquinates monoubiquinated histone H2B (H2Bub). Does not seem to be a component of the TREX-2 complex. Seems to act independently of the SAGA multiprotein complex. The DUB module is responsible for the major H2Bub deubiquitinase activity in Arabidopsis.", "AFDB_id": "AF-Q9LEW0-F1-model_v4" }, { "swissprot_id": "Q90YI8", "sequence": "MMEKRQPELCPGSPDAESGPGKREDAAIISRQNGCKEDEESKREEGDKEGGGRFKGDEETDDVPLQNSSNGTSISIIINGVTKETASHNALDLKREVPVIELSRRDAIKAVEQRTESHLVPITELRRPPQLPLPPQQRDDARMVQLSPNAFPVPARAMLYNLAQPLAAINSLGGESEQYSMYPSNRVKRRPAPYEVELDEAKIVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYISFLSNLLEDQDGGRNVSSTTDGETGLMVGAHEVGPQGGPHQDRVVGLARDDIMETMSPGSSCGSLPDGDADGSPESFMEDQDSPPAPRTLTASRGPPLHLTTRDLRRNGRPLDGSSRR", "function": "Transcription factor that plays a pivotal role in hemopoietic and endothelial development.", "AFDB_id": "AF-Q90YI8-F1-model_v4" }, { "swissprot_id": "P37590", "sequence": "MEWLVKKSCCNKQDNRHVLMLCDAGGAIKMIAEVKSDFAVKVGDLLSPLQNALYCINREKLHTVKVLSASSYSPDEWERQCKVAGKTQ", "function": "Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates.", "AFDB_id": "AF-P37590-F1-model_v4" }, { "swissprot_id": "Q9USQ2", "sequence": "MSEIHVKTALSRLADKYLQNSKNPSVPYTIETIVSFFQEIIHSISPDTFQLDIDDILYKIYSKIPPEENNDALFSKLSNLVSRLKSQTVIHNKSQILYFLYLLSPISQSSRDVSSHLLDESISNPINIPSTEVESSNFGQTRYDQVPENPQITDWDEGLENESSISIAHDSSRLNRSTETSSVQHTLITEADLLSSISYVLQGISTEYVQFKNELALLSKRIPVQYLLQMRALSETGLLYQELKVFSNYDPSVSQSIDGDNVSKAFINDQSLALQSLKSVISKELTNFLALIASLDSQIRADASLEKPMVTIRRCIAWTQVAKLKLRILSSVVNDNMNQENKKRLIQVVSKYNVHGDPLIQELSDKILTEITGPLYEMIENWIYKGELVDPYQEFFVKEKNGSESHDHQGQGDVVWKGKYFLDKELIPSFLSEELVDKIFLIGKSLNFARYGCGDFDWAQEHYQKLVKKLSYRDPHSLETVVDKAYTESINHLVYLMEEVFHLTDHLKAIKKYLLLGQGDFVDLLMESLGNSLDQPANTLFRHNLTASLESAIRSSNASYEPEYVLKRLDARLLELSHGETGWDVFTLEYKVDSPINVIITPYCSRQYLKIFNFLWRLKRIEFALAHSWRRVNLGERNVFRNLDYTKFEWHFVSCHLAEMIHFVCQLQYYILFEVIEISWQELQLAMEKPNATLDTYIEAHEKYVTSITHKGLLGGGKSRNEDSFLHQLHDILKVILNFHDAIELLYNFSCSLSNRIRINVPISTDALAAQYTPIKNELSNFTEEFQVRLQKLLHGLASHKDPEMRFLSVRLNYNEFYVSHRRRHDKDVTSQ", "function": "Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles.", "AFDB_id": "AF-Q9USQ2-F1-model_v4" }, { "swissprot_id": "P75528", "sequence": "MMTVEVFSVIILVLLFLILALTLLFVLLNKRTRSFVIRTFTGLFRSKHTTSQKNFYDNLTSTLLRLSTDKIGAIIAIENQDSLESYVNIGYRVTSDFSPELLVTIFYNKQSPLHDGAVIVRDYQIVSVSSYFPMTRQLIDVSYGSRHRSALGLTEKCDAIVFIVSETTGKISVAVRGVIKTLSSNSDRLQDQIIHYLTVKPG", "function": "Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.", "AFDB_id": "AF-P75528-F1-model_v4" }, { "swissprot_id": "A0QUA1", "sequence": "MNVLSAALTEAMTTSSADLVVFEPETRTWHRHPWGQVHLRAQNVAERIGQDGSSAVGIVGEPTVEGVAAILGALLAGSAVSILPGLVRGADPDQWADSTLNRFANIGVTTVFSHGSYLEQLRTRDSSLVIHDDAEVAHAQRSTTLELGAPLGEFAVLQGTAGSTGTPRTAQLRPDAVLANLRGLAERVGLAGSDIGCSWLPLYHDMGLTFLLSAAVGGTETWQAPTTAFASAPFSWVHWLTESRATLTAAPNMAYGLIGKYSRRLTDVDLSAMRFALNGGEPVDIDGTARFGTELSRFGFDPGALSPSYGLAESSCAVTVPVPGVGLKVDEITVTTEAGSSTQKLAVLGHAIAGMEVRLQPGDEDAGVVDREVGEVEIRGTSMMSGYRGEAPLDPGEWFPTGDLGYLTDDGLVICGRKKELITVAGRNIFPTEIERIAARVKGVREGAVVAVGTNERAVRPGLVIAAEFRGPDEAGARSEVVQRVASECGVVPADVVFLAPGSLPRTSSGKLRRLEVKRQLEESKG", "function": "Activates lipidic moieties required for mycobactin biosynthesis. Converts medium- to long-chain aliphatic fatty acids into acyl adenylate, which is further transferred on to the phosphopantetheine arm of the carrier protein MbtL. Shows a strong preference for palmitic acid (C16) and cannot use short-chain fatty acids. Proceeds via a Bi Uni Uni Bi ping-pong mechanism. During the first half-reaction (adenylation), fatty acid binds first to the free enzyme, followed by ATP and the release of pyrophosphate to form the adenylate intermediate. During the second half-reaction (ligation), holo-MbtL binds to the enzyme followed by the release of products AMP and acylated MbtL.", "AFDB_id": "AF-A0QUA1-F1-model_v4" }, { "swissprot_id": "A0R2G4", "sequence": "MGLDLSADPIALTAALVDIPSVSRDERRIADEIEAALRAQAPHFEVIRNGDAVLARTNLGRPSRVMLAGHIDTVPIADNLPSRIVDGEMYGCGTSDMKAGDAVFLHLAATITEPTHDITLVMYDCEEIESSANGLGRIERELRDWLTADVAILGEPSGGYIEAGCQGTIRVVISAKGTRAHSARSWLGDNAIHKLAPVLDRLASYQARSVDIDGCVYREGLSAVRIDGGIAGNVIPDAASVTVNFRFAPDRDVDQAVAHVHEVFDGLDVTLELTDAAAGALPGLTQPAAAALVAAAGGQVRAKYGWTDVARFAALGIPAVNYGPGDPNLAHRVDERVQVAAITAAADMLRTYLTT", "function": "Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.", "AFDB_id": "AF-A0R2G4-F1-model_v4" }, { "swissprot_id": "Q7USI0", "sequence": "MSFQVPTVGVEEEYQLVDPRSGALIPNCKEVMRTIRRNGGSEEAHSEIQHELHLNQIEMASDVCSSLEEVRDALTQTRRMLIDAARSNETELASAGTNPLPIPTDDALTPKDRYQAMTDRYQQIARDLFIFGCHVHVAMEDRELGIQVMNRCRRWLPILQAITANSPYWDGVDTGYASYRRELWAQWPMAGPPAHFDSLADYQSCVDDLVACGAIKDESFLYWDIRLPTRVPTIEFRAADVMTRVEETVGYVGMIRAIVMLAISEEEQGKPIVPIRPSVLSYAIWHAARYGMNEQLVDPESREMIPASELLNRLMTAIDPALKATGEARPVEAFANQLIKSGTGADRQRRGGELSSVVANVVAETVPSAILA", "function": "ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.", "AFDB_id": "AF-Q7USI0-F1-model_v4" }, { "swissprot_id": "Q02487", "sequence": "MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMKR", "function": "Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.", "AFDB_id": "AF-Q02487-F1-model_v4" }, { "swissprot_id": "Q8K1A6", "sequence": "MHKRNGPQAPPGRGAVTARQLGLLVDFSPDGLMIPEDGINEEELEAEFLALVGGQPQALEKLKGQGPLPMEAIEKMARLCMRDLDEDEEGTDEDDVEADEDLLAELNEVLGEEQKAVEPLMPVAQPKPSGPNPGVEATLQERLTLYQSALESARQAGDSAKMRRYDRGLKTLENLLVSAKKGNIINEADIPPPVASGKGAAAGHSHTQATSQLASVSPPAPESSGTLEAPSTTTPTSAKPQLPPDPCSPLARLQSLQHEYKLAALRAKHQDDTATATRHLRIAKSFDPVLEALSRGELVDLSRLPPPPDQLSPEPPLPAAQPLTSASTLTRPEVPQPPRNLLEALEQRMERYHVAAAQAKAKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPMQGLESAEPSQQSLVGVLETAMRLANHDEGSDDEEEETPKKQNTPAASTTQLKSSPSKAPPSGPAPAGKAAPKGTSNRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDIAKVPPAPVNKDDFVLVQRPGPGLSQEAVRRYGELTKLLRQQHEMCLNHSTQFTHLGNIAETIKFEKLAEDCKRSMDTLKQAFARSLPTPAARFEQRTFSVIKVFPDLSNSDMLLFIVKGINLPTPTGLSPSDLDAFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINRGHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLGTLETACEVHEILEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVIDHIPAAMPTVTGPKAKAPLIPASSREAGNRSARPLHSLSVLAFDQERLERKILALRQARRPVPPEVAQQYQDVVQRSQWQRAQLEQGGAALRREYASHLERQLHFYTEAARRLGYDGSREAAKEALYRRNLVESELQRLRR", "function": "Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses.", "AFDB_id": "AF-Q8K1A6-F1-model_v4" }, { "swissprot_id": "P21250", "sequence": "MKILFCLLLLAITALEAGVVKRYNKRFAGFNVAGIGGNAGCVVVDNKLFANSFFLRELTTEEQRELAQYIEDSNRYKEEVKESLEERRKGWQLARDGKEDSKVLSALAEKKLPKPPKKPSFCSAGDTTQYYFDGCMVQNDKIYVGRAYVRDLTPDEVTQLKTFDAKMTAYQKYLSSTIQKQVDSLFGEKSNLFNLFADTRTEATSQASDDATAGATTTQAPVEAPEPPHFCVAIY", "function": "Aspartyl protease inhibitor.", "AFDB_id": "AF-P21250-F1-model_v4" }, { "swissprot_id": "B8DJT6", "sequence": "MSISDDISPVPPAPVSEPNAGQDAGQDAAPAHMAARAEALRDQLNYHSHRYYVLDDAEISDAEYDALFRELQDIEAEWPSLRTPDSPTHRVGDTVVAALETQAHTLRMYSLDNAFSAEEWDGFIQRMLRAEPDAPTAFWCDPKMDGLALEVIYENGVFTTALTRGDGEKGEIVTTAMRTVRNLPLRLHGEGPHPARLEVRGEVVITRAEFDALNAARRGAGEKLFANPRNAAAGSVRQLDASVTAGRPLRFLAYGVGQVVWPAETSDGAASAAQGPEARWATHGQVMAALADYGFGTPPDARRCETPAQVMAYYEDLGRRRSELPFDIDGVVAKLDDLSAQAALGYTARAPRWAIALKFPAHQATTRLEHIAIQVGRTGVLTPVAELAPVAVGGVTVSRATLHNEDEIRAKDLRVGDMVVVQRAGDVIPEVVRPLVDQRPASGLPEFEFPAECPVCHTPVRREPGEAAWRCVNVGCPAVVRQSIIHFVSKAGLDIQGVGRRWVELLVDRGKVTSPADLFGLDKQTLLAFERMGPKLAENFIAAFDTARTGATLNRLICALGIRHVGEQTARTLAAHFADLDALGAAQAETLQQLPDIGPEVAASIRAFFANEGNRALLERLRGVGLWPVRPVRPEADAAGAPGEGSGPLAGLRVLFTGSLTTLTRSDAERRAVAAGANILGSVSKKLDLLVVGDKPGSKLDKATKLGIRVLREQEFLDLLEGRGGDVPEDGDGAPGNEDEAPEVSADVPAAPEVLADAPAAISADASSGVAPGVSGGPDRADMTDRTVRTDSVDAPAMPRKKDQHSLL", "function": "DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.", "AFDB_id": "AF-B8DJT6-F1-model_v4" }, { "swissprot_id": "P46678", "sequence": "MSSIVNKSGTRFAPKVRQRRAATGGTPTPKPRTPQLFIPESKEIEEDNSDNDKGVDENETAIVEKPSLVGERSLEGFTLTGTNGHDNEIGDEGPIDASTQNPKADVIEDNVTLKPAPLQTHRDQKVPRSSRLASLSKDNESRPSFKPSFLDSSSNSNGTARRLSTISNKLPKKIRLGSITENDMNLKTFKRHRVLGKPSSAKKPAGAHRISIVSKISPPTAMTDSLDRNEFSSETSTSREADENENYVISKVKDIPKKVRDGESAKYFIDEENFTMAELCKPNFPIGQISENFEKSKMAKKAKLEKRRHLRELRMRARQEFKPLHSLTKEEQEEEEEKRKEERDKLLNADIPESDRKAHTAIQLKLNPDGTMAIDEETMVVDRHKNASIENEYKEKVDENPFANLYNYGSYGRGSYTDPWTVEEMIKFYKALSMWGTDFNLISQLYPYRSRKQVKAKFVNEEKKRPILIELALRSKLPPNFDEYCCEIKKNIGTVADFNEKLIELQNEHKHHMKEIEEAKNTAKEEDQTAQRLNDANLNKKGSGGIMTNDLKVYRKTEVVLGTIDDLKRKKLKERNNDDNEDNEGSEEEPEIDQ", "function": "General activator of RNA polymerase III transcription.", "AFDB_id": "AF-P46678-F1-model_v4" }, { "swissprot_id": "Q02896", "sequence": "MLFSWPYPEAPIEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILIGMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFAETQEILIKDEKKRKESSFRIQMVISFIMCGIVTILTWIYVVVQKPAIFQVLYGILTLLVVVLSGWLTYYHVHDSFAKKNLFITMVMGMIPFVIGFICWQLDIHLCSFWIYIRRTYLALPLGVLLELHAWWHLLTGTGVYIFVVYLQYLRILTHGNPNDFLFIWRWGFFPELVRKGLPIGTSYSLEYLGPIVNTQVDDETKKNN", "function": "Acyl-CoA-independent ceramide synthase that catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response.", "AFDB_id": "AF-Q02896-F1-model_v4" }, { "swissprot_id": "P32375", "sequence": "MPINAITSDHVIINGANKPATIVYSTESGTILDVLEGSVVMEKTEITKYEIHTLENVSPCTILPGLVDSHVHLNEPGRTSWEGFETGTQAAISGGVTTVVDMPLNAIPPTTNVENFRIKLEAAEGQMWCDVGFWGGLVPHNLPDLIPLVKAGVRGFKGFLLDSGVEEFPPIGKEYIEEALKVLAEEDTMMMFHAELPKAHEDQQQPEQSHREYSSFLSSRPDSFEIDAINLILECLRARNGPVPPVHIVHLASMKAIPLIRKARASGLPVTTETCFHYLCIAAEQIPDGATYFKCCPPIRSESNRQGLWDALREGVIGSVVSDHSPCTPELKNLQKGDFFDSWGGIASVGLGLPLMFTQGCSLVDIVTWCCKNTSHQVGLSHQKGTIAPGYDADLVVFDTASKHKISNSSVYFKNKLTAYNGMTVKGTVLKTILRGQVVYTNANGVSKTPLGQTLLDSRR", "function": "Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring. Involved in the utilization of purines as secondary nitrogen sources, when primary sources are limiting.", "AFDB_id": "AF-P32375-F1-model_v4" }, { "swissprot_id": "Q03FX9", "sequence": "MHTGQIIQLLAGFYDVLTEDHKIVRTRARGNFRNQKTSPLVGDMVDFKESENDTGYITKIHTRENELVRPPLANIDQAVIVTAATEPSFSANLLDRQLVALAEKHIEAILYFSKTDLLSPTEFQDLQKIAGYYQKIGYQVIFPISSQPDADLIELKESFKNQLTIFMGQTGAGKSTLLNRIDSKLNIATGEVSQALNRGKHTTRKVSLIPIEDGLVADTPGFSTYAVFEMADTQLKEYFIDFKKLSQNCRFRECLHLNEPGCAVKAAVEDGSVLSSRYANYEQFIELIRNQKPEYKRKGYQKKDRRKKK", "function": "One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.", "AFDB_id": "AF-Q03FX9-F1-model_v4" }, { "swissprot_id": "Q9VEI3", "sequence": "MYAYNKMGRVPELVICSFIVVTLLVIHFFSDLLRASLGGYYNQDVTLSQLVESQNSDYAWFLKLLVNCFGYSCVFVPGFLIYKYVGRINYLERGNKTFLHKAINMCITGNSGYDQLDAGTSTADKDRPAASTAPKRTSSQEAVQLLWCFGGLMISYLTWGVLQEKIMTQNYLNFTGESAKFKDSQFLVFSNRLLAFLVALAYLQWQPSPVRHRAPLYKYSYASFSNIMSAWFQYEALKFVNFPTQVLAKSCKIIPVMLMGKIMSKAKYESYEYVTALLISLGMIFFMSGSSDSSKASGVTTLTGIFLLSMYMVFDSFTANWQGSLFKSYGMTPLQMMCGVNLFSSIFTGASLSMQGGFMDSLAFATEHPKFVFDMVVLSVCSAVGQLFIYHTIDVFGPVVFTIIMTLRQAVAIMLSCFIYQHSISLLGIFGVLIVFVAIFLRVYCTQRLRAIRKRAEANKPKMAV", "function": "Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Required for the dorsoventral patterning, suggesting that it mediates the transport of the sulfate donor required for the sulfotransferase activity of pip (pipe).", "AFDB_id": "AF-Q9VEI3-F1-model_v4" }, { "swissprot_id": "D7REY3", "sequence": "MFADINKGDAFGTWVGKSVPRREDADILAGRAEYIADIKLPGMLEAAFLRSPFAHARIVSIDVSQALALPGVYDVMVGADIPDYVKPLPLMITYQNHRETPTSPLARDIVRYAGEPVAVVAAINRYVAEDALELIVVKYEELPVVASIDASLAVDGPRLYEGWPDNVVAKVSSEIGDVDAAMASADLVFEERFEIQRCHPAPLETRGFIAQWDFKGENLNVWNGTQIINQCRDFMSEVLDIPASKIRIRSPRLGGGFGAKFHFYVEEPAIVLLAKRVKAPVRWIEDRLEAFSATVHAREQVIDVKLCAMNDGRITGIVADIKGDLGASHHTMSMGPVWLTSVMMTGVYLIPNARSVAKAIVTNKPPSGSYRGWGQPQANFAVERMVDLLAHKLQLDPAAVRRINYVPEARMPYTGLAHTFDSGRYEVLHDRALKTFGYEAWLERQAAAQAQGRRIGIGMSFYAEVSAHGPSRFLNYVGGRQGGYDIARIRMDTTGDVYVYTGLCDMGQGVTNSLAQIAADALGLNPDDVTVMTGDTALNPYTGWGTGASRSITIGGPAVMRAATRLREKILSIARHWLQADPDTLVLANRGVMVRDDPGRYVSFASIGRAAYCQIIELPEDVEPGLEAVGVFDTVQLAWPYGMNLVAVEVDEDTGAVSFLDCMLVHDMGTIVNPMIVDGQLHGGIAQGIAQALYEELRYDENGQLGTGSFADFLMPTASEIPNMRFDHMVTESPLIPGGMKGVGEGGTIGTPAAVVNAIENALRPITNSKLNRTPVTPDRILTAISAGACA", "function": "Catalyzes the hydrolitical oxidation of 1,3,7-trimethylxanthine (caffeine) by incorporation of an oxygen atom originating from a water molecule into position C-8 to produce 1,3,7-trimethyluric acid (TMU). Coenzyme Q0 is the preferred electron acceptor and coenzyme Q2 can also be used, but oxygen and NADP cannot.", "AFDB_id": "AF-D7REY3-F1-model_v4" }, { "swissprot_id": "B7IFR8", "sequence": "MLTLLEKFIQKIEEYNLIEENDRILVAVSGGVDSSVLLNLLARVQEYFKFSIFCATVDHGIRKESKEEVKFVYNMAQSLNVECFIKEFDVPLYAKENKLSIEEAARKLRYKFLNEIAKKINANKVATAHNLNDLAETVLFRLARGTGPFGIYGMKPRNGNIIRPLLFFERKEIEQFATENKIPFVVDKTNFDTKYTRNFIRHKIIPIFKEINPLFEQAVLRFVENVWELDSFVKDKLNVETFEFEGRIFFKVPKDEYILVEFIRRKTMEHFGRAPDKEKLDRLKKNLYKTSFKISFWGDYGVEISYGYGVLGKFIEHMNYECSMDCQNNVNFGPFVVKFGNNGIIFKKMNLTIRNYRFGDKTKGGKKLKEIFVEKKVPSFIRRIIPIFVDEDGYVFYIPNVFLDRDYLSKEENGISIKVEMKGGFWF", "function": "Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.", "AFDB_id": "AF-B7IFR8-F1-model_v4" }, { "swissprot_id": "O68556", "sequence": "MNNHSYLKKNSFHEGDARELLKCIEEESIALSVWSPPYHVGKKYEEGQTYEQWSSLLTKVIALHYPILKPGGFLVINIDDILAFPDPRMPRFQAVNLKKHRVSVTREDILNALKLEPELTKYQLAKKFNCSEQTIERRLKGNNIRGGKYNVQTKVKLAGPVLEKAAEEAGLYLYDRRIWAKDPAWQNSQWHSNSYKAVSEFEHLYIFWKPGETVIDRNKLSKEEWASWASRGIWYIPSVRKNDDHEAKFPLLLPQRLIKLLTQKGDTVLDCFMGSGTTAVAALSESRNFIGIEKEPKYIQLSNKNVETFYISRNKEASKIKETNHSVTDEKKKAEQLELLLEENENSL", "function": "A beta subtype methylase, recognizes the double-stranded sequence 5'-GCCNNNNNGGC-3', methylates C-2 on both strands, and protects the DNA from cleavage by the BglI endonuclease.", "AFDB_id": "AF-O68556-F1-model_v4" }, { "swissprot_id": "Q9HGN5", "sequence": "MDEDETTYPEALRRLLIETPAAIWQLDDESAQCNNCGGPFTWFRRRHHCRWCGKLFCYNCCNSFAKLPVSSVSVDPTEDLIPQDMFIRDPDFLANDNDDDNDSQDSSWINVRVCVNCRQQLSELKELDLPYPITTCLNDDTTTRSNNQVIQSSCGNNLQRIEEPDDFVECPVCYAPLSSFKTLSERESHVANCLSNNSSSPRNMTEFLKHARRYISMQLSETSPCLGQECIICFEEFAAGDRVARIEYCLCIFHLKCYRDWLSTGAAGCPVHAATLHLS", "function": "Functions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate.", "AFDB_id": "AF-Q9HGN5-F1-model_v4" }, { "swissprot_id": "Q5REK7", "sequence": "MMATGTADSQARFGQSVKGLLTEKVTTCGTDVIALTKQVLKGSRSSELLGQAARNMVLQEDAILHSEDSLRKMAIITTHLQYQQEAIQKNVEQSSDLQDQLNHLLK", "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.", "AFDB_id": "AF-Q5REK7-F1-model_v4" }, { "swissprot_id": "Q5A5U4", "sequence": "MKFLAILSLSSSALATISSIQLFAKSDDSKVDGLGLYSKHEGAAIDYLFLGKNGADLKYDDEKKQIFQELKTSSITVRQSFTLGGDVYELGATDNFIPVTINKDGTLSFTGDDKVYASKNVNDPYRYSESEYAVSNKKTDDSAPITIVAKFSDDKAAETSGVAQAASSSAGPAQASVSNFEGAAGQNKLSYGVGMAAVVAGLVM", "function": "Component of the cell wall involved in virulence. Does not seem to have a major role in maintaining cell wall integrity but plays a role in the relationship between C.albicans and the host.", "AFDB_id": "AF-Q5A5U4-F1-model_v4" }, { "swissprot_id": "O67931", "sequence": "MAKHVVVIGGGVGGIATAYNLRNLMPDLKITLISDRPYFGFTPAFPHLAMGWRKFEDISVPLAPLLPKFNIEFINEKAESIDPDANTVTTQSGKKIEYDYLVIATGPKLVFGAEGQEENSTSICTAEHALETQKKLQELYANPGPVVIGAIPGVSCFGPAYEFALMLHYELKKRGIRYKVPMTFITSEPYLGHFGVGGIGASKRLVEDLFAERNIDWIANVAVKAIEPDKVIYEDLNGNTHEVPAKFTMFMPSFQGPEVVASAGDKVANPANKMVIVNRCFQNPTYKNIFGVGVVTAIPPIEKTPIPTGVPKTGMMIEQMAMAVAHNIVNDIRNNPDKYAPRLSAICIADFGEDAGFFFADPVIPPRERVITKMGKWAHYFKTAFEKYFLWKVRNGNIAPSFEEKVLEIFLKVHPIELCKDCEGAPGSRC", "function": "Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.", "AFDB_id": "AF-O67931-F1-model_v4" }, { "swissprot_id": "Q7VGU1", "sequence": "MNHCILACDVGLKRIGLATLKQEIILPLPPIIRINRNQAAKELDNVLKERNIHILVVGMPSGGEAEHSDTQKRISHFISLLSFEGEICFVNEDYTSFNALQSLSYMKRQNRARAQKDGRIDSLSACEILQRYIQSQKS", "function": "Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.", "AFDB_id": "AF-Q7VGU1-F1-model_v4" }, { "swissprot_id": "Q2NIS7", "sequence": "MNYKPRTKVIAGNWKMHKCKDEALEFIQKVSLQVPDQTQVQTLIFPQLTLLDPLVQLQGANLQVGAQNMFYETEGAFTGEVSPQNLLSLGVKHVLLGHSERRTLFGETDQTVNLKLLSALKHKLVPTVCVGESLLTKENNQTQMFLDQQLTNIFAGVPEEALKNMIIAYEPVWAIGTGKSANPQDANKTIEQIREKVTALYSFQASCAIRIIYGGSLSVANIKSILEQPAIDGILAGKASLQTEDFLFFAQIASKQVLVSTKDIFQKNDCPFCY", "function": "Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).", "AFDB_id": "AF-Q2NIS7-F1-model_v4" }, { "swissprot_id": "Q255R8", "sequence": "MKQQLLLLEDVDGLGRSGDIVTARPGYVRNYLLPQKKAIIAGAGTLRLQAKLKEERLLRAAEDRAESEKLAELLKDLVLEFQVRVDPDNNMYGSVTISDIIAEAAKKNVILTRKNFPNAHYAIKNLGKKSVPLKLKEGVTATLFVEVSSESAYIAVLNQQSSQEQTVAAEELE", "function": "Binds to the 23S rRNA.", "AFDB_id": "AF-Q255R8-F1-model_v4" }, { "swissprot_id": "Q13435", "sequence": "MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF", "function": "Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.", "AFDB_id": "AF-Q13435-F1-model_v4" }, { "swissprot_id": "Q9M9K1", "sequence": "MGSSGDVNWKLADHPKLPKGKTIGLIVLDGWGESDPDQYNCIHKAPTPAMDSLKDGKPDTWRLIKAHGTAVGLPSEDDMGNSEVGHNALGAGRIYAQGAKLVDLALASGKIYEDEGFKYISQSFEKGTVHLIGLLSDGGVHSRLDQVQLLLKGFAERGAKRIRVHILTDGRDVLDGSSVGFVETLEADLAALRAKGVDAQVASGGGRMYVTMDRYENDWSVVKRGWDAQVLGEAPHKFKSALEAVKTLRAEPGANDQYLPSFVIVDDNGKAVGPIVDGDAVVTFNFRADRMVMHAKALEYKDFDKFDRVRVPDIRYAGMLQYDGELKLPSRYLVSPPLIDRTSGEYLAHNGVRTFACSETVKFGHVTFFWNGNRSGYFNEKLEEYVEIPSDSGISFNVQPKMKALEIAEKARDAILSGKFDQVRVNLPNGDMVGHTGDIEATVVACEAADRAVRTILDAIEQVGGIYVVTADHGNAEDMVKRDKSGKPALDKEGNLQILTSHTLKPVPIAIGGPGLSAGVRFRQDIETPGLANVAATVMNLHGFVAPSDYETSLIEVVEK", "function": "Catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA). Required for guard cell function (e.g. blue light-, abscisic acid- (ABA), and low CO(2)-regulated stomatal movements) and fertility (e.g. pollen grains production).", "AFDB_id": "AF-Q9M9K1-F1-model_v4" }, { "swissprot_id": "P32710", "sequence": "MLTPLTAFAGVRLRWPAMMRLTCIGILAQFALLLLAFGVLTYCFLISDFSVIYVAQHSYSLLSWELKLAAVWGGHEGSLLLWVLLLSAWSALFAWHYRQQTDPLFPLTLAVLSLMLAALLLFVVLWSDPFVRIFPPAIEGRDLNPMLQHPGLIFHPPLLYLGYGGLMVAASVALASLLRGEFDGACARICWRWALPGWSALTAGIILGSWWAYCELGWGGWWFWDPVENASLLPWLSATALLHSLSLTRQRGIFCHWSLLLAIVTLMLSLLGTLIVRSGILVSVHAFALDNVRAVPLFSLFALISLASLALYGWRARDGGPAVHFSGLSREMLILATLLLFCAVLLIVLVGTLYPMIYGLLGWGRLSVGAPYFNRATLPFGLLMLVVIVLATFVSGKRVQLPALVAHAGVLLFAAGVVVSSVSRQEISLNLQPGQQVTLAGYTFRFECLDLQAKGNYTSEKAIVALFDHQQRIGELTPERRFYEARRQQMMEPSIRWNGIHDWYAVMGEKTGPDRYAFRLYVQSGVRWIWGGGLLMIAGALLSGWRGKKRDE", "function": "May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.", "AFDB_id": "AF-P32710-F1-model_v4" }, { "swissprot_id": "P64686", "sequence": "MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDAQYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEFWDENGGAASGEIELAALNIP", "function": "Thiesterase that shows a preference for long chain fatty acyl groups.", "AFDB_id": "AF-P64686-F1-model_v4" }, { "swissprot_id": "Q9FN69", "sequence": "MATGQNRTTVPENLKKHLAVSVRNIQWSYGIFWSVSASQSGVLEWGDGYYNGDIKTRKTIQASEIKADQLGLRRSEQLSELYESLSVAESSSSGVAAGSQVTRRASAAALSPEDLADTEWYYLVCMSFVFNIGEGMPGRTFANGEPIWLCNAHTADSKVFSRSLLAKSAAVKTVVCFPFLGGVVEIGTTEHITEDMNVIQCVKTSFLEAPDPYATILPARSDYHIDNVLDPQQILGDEIYAPMFSTEPFPTASPSRTTNGFDQEHEQVADDHDSFMTERITGGASQVQSWQLMDDELSNCVHQSLNSSDCVSQTFVEGAAGRVAYGARKSRVQRLGQIQEQQRNVKTLSFDPRNDDVHYQSVISTIFKTNHQLILGPQFRNCDKQSSFTRWKKSSSSSSGTATVTAPSQGMLKKIIFDVPRVHQKEKLMLDSPEARDETGNHAVLEKKRREKLNERFMTLRKIIPSINKIDKVSILDDTIEYLQELERRVQELESCRESTDTETRGTMTMKRKKPCDAGERTSANCANNETGNGKKVSVNNVGEAEPADTGFTGLTDNLRIGSFGNEVVIELRCAWREGVLLEIMDVISDLHLDSHSVQSSTGDGLLCLTVNCKHKGSKIATPGMIKEALQRVAWIC", "function": "Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication. Regulates also trichome cell wall maturation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Activates the transcription of GL2.", "AFDB_id": "AF-Q9FN69-F1-model_v4" }, { "swissprot_id": "Q5JTJ3", "sequence": "MGPGGPLLSPSRGFLLCKTGWHSNRLLGDCGPHTPVSTALSFIAVGMAAPSMKERQVCWGARDEYWKCLDENLEDASQCKKLRSSFESSCPQQWIKYFDKRRDYLKFKEKFEAGQFEPSETTAKS", "function": "Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.", "AFDB_id": "AF-Q5JTJ3-F1-model_v4" }, { "swissprot_id": "Q8NDB2", "sequence": "MLPAAPGKGLGSPDPAPCGPAPPGNTKDIIMIYEEDAEEWALYLTEVFLHVVKREAILLYRLENFSFRHLELLNLTSYKCKLLILSNSLLRDLTPKKCQFLEKILHSPKSVVTLLCGVKSSDQLYELLNISQSRWEISTEQEPEDYISVIQSIIFKDSEDYFEVNIPTDLRAKHSGEISERKEIEELSEASRNTIPLAVVLPTEIPCENPGEIFIILRDEVIGDTVEVEFTSSNKRIRTRPALWNKKVWCMKALEFPAGSVHVNVYCDGIVKATTKIKYYPTAKAKECLFRMADSGESLCQNSIEELDGVLTSIFKHEIPYYEFQSLQTEICSQNKYTHFKELPTLLHCAAKFGLKNLAIHLLQCSGATWASKMKNMEGSDPAHIAERHGHKELKKIFEDFSIQEIDINNEQENDYEEDIASFSTYIPSTQNPAFHHESRKTYGQSADGAEANEMEGEGKQNGSGMETKHSPLEVGSESSEDQYDDLYVFIPGADPENNSQEPLMSSRPPLPPPRPVANAFQLERPHFTLPGTMVEGQMERSQNWGHPGVRQETGDEPKGEKEKKEEEKEQEEEEDPYTFAEIDDSEYDMILANLSIKKKTGSRSFIINRPPAPTPRPTSIPPKEETTPYIAQVFQQKTARRQSDDDKFCGLPKKQDRARIESPAFSTLRGCLTDGQEELILLQEKVKNGKMSMDEALEKFKHWQMGKSGLEMIQQEKLRQLRDCIIGKRPEEENVYNKLTIVHHPGGKETAHNENKFYNVHFSNKLPARPQVEKEFGFCCKKDH", "function": "Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.", "AFDB_id": "AF-Q8NDB2-F1-model_v4" }, { "swissprot_id": "E6MVV9", "sequence": "MNTPPFVCWIFCKVIDNFGDIGVSWRLARVLHRELGWQVHLWTDDVSALRALCPDLPDVPCVHQDIHVRTWHSDAADIDTAPVPDVVIETFACDLPENVLHIIRRHKPLWLNWEYLSAEESNERLHLMPSPQEGVQKYFWFMGFSEKSGGLIRERDYCEAVRFDTEALRERLMLPEKNASEWLLFGYRSDVWAKWLEMWRQAGSPMTLLLAGTQIIDSLKQSGVIPQDALQNDGDVFQTASVRLVKIPFVPQQDFDQLLHLADCAVIRGEDSFVRAQLAGKPFFWHIYPQDENVHLDKLHAFWDKAHGFYTPETVSAHRRLSDDLNGGEALSATQRLECWQTLQQHQNGWRQGAEDWSRYLFGQPSAPEKLAAFVSKHQKIR", "function": "Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys-32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes.", "AFDB_id": "AF-E6MVV9-F1-model_v4" }, { "swissprot_id": "P22469", "sequence": "MSSTNETNQVLQRLNSLKIVETPKEQHEFGKRECYSLDSKKYSLVPATPSSSGHGKFQTELKKRRKNKLNRMYTYEADKNFIKARKSLNF", "function": "Cell cycle regulator that is involved in modulating and adjusting cell proliferation according to the requirements of the developmental program. Interacts with mitotic Cdk1-cyclin complexes to inhibit mitotic entry at the G2/M transition. Likely to function by binding to the hydrophobic patch of cyclins to interfere with the interaction between the complex and certain Cdk1 substrates. At the mid-blastula transition, involved in the cell cycle arrest in G2 of cycle 14 by delaying mitosis and thus reducing cell proliferation allowing cell fate specification and morphogenesis to take place. Acts downstream or in parallel to the checkpoint regulator grp which is also required for the cell cycle pause at cycle 14. During gastrulation, delays mitosis in the ventral region of the embryonic mesoderm thus allowing invagination to be completed before cell division takes place.", "AFDB_id": "AF-P22469-F1-model_v4" }, { "swissprot_id": "B0R664", "sequence": "MTTITPESLPRHELLGLHARVAADTDQSRVGIAGRVVDETMQTVVLRTASGVAQVPKKGATFEFRLTDEAAAPDNGVGTAFKPAGGETRQTTGESVAYVTVDGGRLLSRPERRSENGVDSKWR", "function": "Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.", "AFDB_id": "AF-B0R664-F1-model_v4" }, { "swissprot_id": "Q9XVV5", "sequence": "MVSQLVTYSAHVILFVLVWLLAYTDVVPVLSYLPECLHCLVNYAPFFAVLFLGIYAVFNVVYGVATFNDCAEAKVELLGEIKEAREELKRKRIID", "function": "Stabilizer subunit of the dolichol-phosphate-mannose synthase complex.", "AFDB_id": "AF-Q9XVV5-F1-model_v4" }, { "swissprot_id": "Q9NXE8", "sequence": "MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKKEKKKKHKKHKHRSSSSDRSSSEDEHSAGRSQKKMANSSPVLSKVPGYGLQVRNSDRNQGLQGPLTAEQKRGHGMKNHSRSRSSSHSPPRHASKKSTREAGSRDRRSRSLGRRSRSPRPSKLHNSKVNRRETGQTRSPSPKKEVYQRRHAPGYTRKLSAEELERKRQEMMENAKWREEERLNILKRHAKDEEREQRLEKLDSRDGKFIHRMKLESASTSSLEDRVKRNIYSLQRTSVALEKNFMKR", "function": "Involved in pre-mRNA splicing as component of the spliceosome.", "AFDB_id": "AF-Q9NXE8-F1-model_v4" }, { "swissprot_id": "O17444", "sequence": "MASFQIPVINLEVREVKDIVWEKIQEPVNQRRLILVIVSIALLLDNMLYMVIVPIIPDYLREIGSFDDGPTPPPLRDNITGKIIPVHHDHHGQDSATGILFASKAIVQLMVNPFSGGLIDKIGYDLPMMIGLTIMFFSTAVFACGSSYSVLFFARSLQGAGSAFADTAGLAMIADRFTEENERSQALGIALAFISFGCLVAPPFGGALYQFAGKEVPFLILALVCLLDGLMLLLVMKPVKEAMKQSKDVQDQVIPIWRLLMDPYIAVCAGALTMSNVALAFLEPTISLWMEDNMTTDNWKIGMVWLPAFFPHVLGVVITVKMARKYPQHQWLMAAGGLALEGFSCFIIPFCSGYKMLMLPICVICFGIALIDTALLPTLGYLVDVRYVSVYGSIYAIADISYSIAYAVGPIIAGGVVEAIGFTALNFLIAFSNLAYVPVLRKLRNIYDFKPFENEANILMQDPPNKEYQTYVMHDQKPVEGGVKNHLEYGQQYQQEQETNLDDQQYEYQQQQQGYQQGYQQDQGYQPGYQEQGGSYAPQGQPRVANPFQQQQQQQQQQQQQVQSRGPAAPANPFRQGF", "function": "Involved in acetylcholine transport into synaptic vesicles.", "AFDB_id": "AF-O17444-F1-model_v4" }, { "swissprot_id": "P39732", "sequence": "MVDVQKRKKLLAKAAASASIPAIKGSVPLDSYDIKIIQYKNALYKLNELNRLLNVLVPHLKKKRDNDESYKIIPLVNFILSLCEGPIFNVSPVLAKRYHLLCRFQLIKLSEVQQRLSTNFIDVEGWMFPEEVPLDHYKSCIYNNSLQWKILNSLSCIAQNAIKIYNAKLRQILLERDAYKARSLPFDTSIIEDLLNPVEMTLILDLAVLINDPVRDKSTHSFYKLQWQVMEKLNSCVHSKIFPILRTYYNQLQKFSETRPTSLSNLQKDLPHWEWTLHRIYTFHLRVFSVLCVIISFSRQIFLPNKQHFLDIKTRLSSENVYHYDLIICELMALLSPECDDVTALFELQENLKFWTQTARTDNNSSRTPIFHLQPGLVVELFNNHICKIIPKLRSIMGLLSNWMDCWKYIEKNYKTFDETNDLRENLKEKLERDKALYLEVKNAKSKLKKKPSITKLPASSSPSPSPTSSASPSRQASLESIRTRARAHLASNSSRSPSVSPVRTTFNNKNAETKKSVVSPEKRKLINGRRPRSSSLQSYTNKQQTSYLNSTRHPSIAPPSKLNNQRSNSLQSSTMTLNQKIVQDTVRHLMNKSASTPNPSASSSLAPSPKVSSINNTSSGKSSSTLIANSSDTLAIETLTLDPESNSSELSIKRVRFAGVPPMTEAENPKPTKVGWYKKPAVLHYPPIPASAMIKPLQHKSKYNTLRQEEGFTFRKSLRDGLEWENGESGSETTMMPFGIEIKESTGHRIASKIRSKLR", "function": "GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.", "AFDB_id": "AF-P39732-F1-model_v4" }, { "swissprot_id": "Q0D158", "sequence": "MAKPNQRHACDRCHGQKLRCIHSGGGPCVRCAKAKATCSWSQSLRSNRLKRHNVPISDVPLACAQLATQSTDPNTPQFGAYMSQPSSAGVDIDINLLQTQFTDSTPWALPAGRYPSPASQEMETYNVGHTEADLPTTADWMWPAVANGPVQTTPPANWQQAFNQEWAMMASQHPVATMNTPSRTSPVSDAVDPPNTVCLLATIRELSELNVDLYAHEATVPRPPASLDEPISWKNKDFAIDRTFHLSQRLIEIVNKRYPRYLETARMQTPEGTPERTSESSPSGPPLDQGSCLLVLSCYTRLIETYDRIFANMQGCLDRSSVTAREDYVNMPSVQVGSFSLPHSSSLQIVLILQLARQLLTRMGEIIKAVQPEKGTNSADVTLSESATGGLLLSSALETVSAEEDRLMKRITKLRSTLIELNIL", "function": "Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of isoflavipucine.", "AFDB_id": "AF-Q0D158-F1-model_v4" }, { "swissprot_id": "P84626", "sequence": "MAEEEPKIGVYICHCGENIAGAVNIEEVKKFAETLPNVVVVRDYLFMCSDPGQELIKQDIKEGRVNRVVVAACTPRTHEPIFRKACEDAGLNKYYFEMANIRDQCSWAHWHEKEKATEKAKQIIAAAVAKARLLEPLEDRYVDITQKVLVIGGGIAGIFAALDIANAGYKVYLVERNPSIGGNMAKLDKTFPTNDCSACILTPLMVEVANHPNIELLTYSEVEAVEGTVGNFKVKVRKKQTWVDWDLCTGCGACTDVCPPKARVPDEFNEGLSKRGAIYIQFPQAVPKKAVIDIDACIECGGRKFGTEPRKTKDGKPILAPCEKVCPTGAADRTKPRNPEGELIELDVGAIIVATGYKVMDKTHFKEFAPDSPNVITALQMERLISATGPTEGKLIVPSDIPKYEEWKKKVAKGEEVELEARKPHRIVYVSCVGSRDERFHTYCSKVCCMYMLKQAMLLKEKYPDLDIYIFFIDVRTPGKDFDEYYMRCRQLGIKVIKGKVGGIRRMPDERLWVRGYDAEIGKPVEVIADLVVLATAIEPSDGTIELARKLGINIGAEGFFRERHTKLYPVDTMTEGIFICGCAQGPKDIPDSVAQAKAAASSAMSLIAPGKMKLEPLVSEVDKEKCSGCGICVPLCPYGAITMTKYNESMRAEINPALCKGCGVCAAACPSKAIKLHGFTFEQVLAQVRTLAKRGIVEVL", "function": "Has oxidoreductase activity. The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane.", "AFDB_id": "AF-P84626-F1-model_v4" }, { "swissprot_id": "Q9D708", "sequence": "MADCYTELEKAVVVLVENFYKYVSKHSLVKNKISKSSFRKMLQRELNHMLTDTGNRKAADKLIQNLDANHDGRICFDEYWTMIGGITSPMANLIRQQECQQESQQECQQESQQESQQESQQGSS", "function": "Calcium-binding protein. Binds one calcium ion per monomer. Can promote differentiation of adipocytes (in vitro). Overexpression in 3T3-L1 preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake.", "AFDB_id": "AF-Q9D708-F1-model_v4" }, { "swissprot_id": "Q6L1S4", "sequence": "MSLADIIKDIDKSREEQISKINDEYSKRIEELKKSCDSRIQSIKEYYEKKKEADIKTLKKVQEDKIKIDSKSIKMEKRREIVKDALDISYYHLMNITKSKRYDSILNSMVSTAIKTLGEDCEIFASESDAKKINNAKADHKINGGIIAYSKDKKRMLDFRLNSIFENIKDDLASYFYENIEE", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-Q6L1S4-F1-model_v4" }, { "swissprot_id": "P42948", "sequence": "MTSPESLSSRHIRQGRTYTTTDKVISRSSSYSSNSSMSKDYGDHTPLSVSSAASETLPSPQYMPIRTFNTMPTAGPTPLHLFQNDRGIFNHHSSSGSSKTASTNKRGIAAAVALATAATIPFPLKKQNQDDNSKVSVTHNESSKENKITPSMRAEDNKPKNGCICGSSDSKDELFIQCNKCKTWQHKLCYAFKKSDPIKRDFVCKRCDSDTKVQVNQVKPMIFPRKMGDERLFQFSSIVTTSASNTNQHQQSVNNIEEQPKKRQLHYTAPTTENSNSIRKKLRQEKLVVSSHFLKPLLNEVSSSNDTEFKAITISEYKDKYVKMFIDNHYDDDWVVCSNWESSRSADIEVRKSSNERDFGVFAADSCVKGELIQEYLGKIDFQKNYQTDPNNDYRLMGTTKPKVLFHPHWPLYIDSRETGGLTRYIRRSCEPNVELVTVRPLDEKPRGDNDCRVKFVLRAIRDIRKGEEISVEWQWDLRNPIWEIINASKDLDSLPDPDKFWLMGSIKTILTNCDCACGYLGHNCPITKIKNFSEEFMRNTKESLSNKSYFNTIMHNCKP", "function": "Putative chromatin regulator.", "AFDB_id": "AF-P42948-F1-model_v4" }, { "swissprot_id": "O22901", "sequence": "MGVTLEGQRKESIWVLMRRQRARRALVKKIMIRPRKSVEASRRPCRAIHRRVKTLKELVPNTKTSEGLDGLFRQTADYILALEMKVKVMQTMVQVLTETNCV", "function": "Transcription factor that modulates the balance between cellular proliferation and differentiation in root growth. Does not act through cytokinin and auxin signaling, but by repressing peroxidase expression in the elongation zone.", "AFDB_id": "AF-O22901-F1-model_v4" }, { "swissprot_id": "O34757", "sequence": "MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGIILTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERVPFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERLEEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKGHGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK", "function": "Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates DesR by phosphorylation.", "AFDB_id": "AF-O34757-F1-model_v4" }, { "swissprot_id": "Q05648", "sequence": "MLSFRSLTSTFGFVSRFQIRRLGTSLSIQNLEVQDGRWKGKLATEKKTNREHKSVDTNIKTMKMLKNPKNSTRYLRRSFVPNHRKQENGRDILEDSLSKDHLKVKSCITITTGEGYDLKRCMKLLTMQGLQPTNLIPDEIVSFSYQDNGNKGDVMILGQNGSIVSWGFSESSVRNCIVPIVKAASLNPLNGEDFETEDMDYVEIEGEQDFDKLSSLDNKVTPRIACESFLSGDLIIINSLDSDQGMLDKAAFSSGLSRSTNLAVLEEAMEKHISKTRTITENISKGTKLNLRSSDALKSIGRLFLIRGKLNLYSELIETPDLYWSEPQLEEIFKNVSRYLDIGPRINILNSKLDYSTDECRALISLLNERNSTFLEWIIIYLIAFELCFEIYHFYQKYSSYCSEPTNDDLDATK", "function": "Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.", "AFDB_id": "AF-Q05648-F1-model_v4" }, { "swissprot_id": "A8MGK0", "sequence": "MLNVTLLGSGGGMPMPERHLSSLMINYKGRKILVDCGEGTQVAIRKMNAGFKSIDIICITHVHGDHIFGIPGLLSTMGNSQRLDPVTIVGPKGISDVMRGLLLSIKQLPYSIEIIEDPKGKLGITNTEQGLKIKEQKDGMNDEITVSTLELDHSAPCFGYSFYLNRRPKFEPEKAIKNDVPRLIWSKLQKGETIVAGDRKYSPDLVLGEQRRGIKLTYITDTRPTKDIPQWINQSDLFICEGTYGDNDDMDKAIKNKHMTFMEAGELAKKGKVKELLLTHFSPALKEPNFYEHNAKKEFAHTTIGYDGYRKNIEYKN", "function": "Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.", "AFDB_id": "AF-A8MGK0-F1-model_v4" }, { "swissprot_id": "Q5PB34", "sequence": "MRVLLTNDDGFDSVGMRVLRDVVSGHFAEVWVSAPARDCSAASRALSVRTPIKTHMRGEREFVVHGTPADSAVIGICEMTSTGKRPDLVISGINYGANTGFTVPYSGTIAAAAAAFDIGVPAIAISQQYNGKRCDNNVETSWQNSRKSVMALVSRLLRDTMWHGKCVMSINVPYSDVQGVKFAGHSCDDGHIKWDGPSMERREITSGDGRCVSYVFDDMRSPNSNDNASDTQLLEQGYIVVTPIGHSMTDHAILDKYCGLQ", "function": "Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.", "AFDB_id": "AF-Q5PB34-F1-model_v4" }, { "swissprot_id": "P70365", "sequence": "MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPEDPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDSNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARVNRQQSSDLNSSSSHTNSSNNQGNFGCSPGNQIVANVALNQGQAGSQSSNPSLNLNNSPMEGTGIALSQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDSKEIASILNEMIQSDNSDNSANEGKPLDSGLLHNNDRLSEGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSVPASTAVSVSGQSQGSASIKLELDAAKKKESKDHQLLRYLLDKDEKDLRSTPNLCLDDVKVKVEKKEQMDPCNTNPTPMTKPAPEEVKLESQSQFTADLDQFDQLLPTLEKAAQLPSLCETDRMDGAVTGVSIKAEVLPASLQPTTARAAPRLSRLPELELEAIDNQFGQPGAGDQIPWANNTLTTINQNKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEDRPTLYSQPYSSPSPTAGLSGPFQGMVRQKPSLGAMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGTPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGAGISPQMQQNVFQYPGPGLVPQGEATFAPSLSPGSSMVPMPVPPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANIQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTDADGNQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE", "function": "Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.", "AFDB_id": "AF-P70365-F1-model_v4" }, { "swissprot_id": "Q44249", "sequence": "MSEKLDFITKNNLWTDKQRDAADKVLAEIDSLGLEMIRLSWADQYGLLRGKALSVAALKAAFSEGSEVTMAPFSFNLVSEWVFNPFTAGGGFGIDEFDELGGVPSVVMVPDPTTFKVLPWADKTGWMLADLHWKSGEPFPLCPRGIMKKAVKSLSDEGYLFKCGIELEWYLTKIVDRSLSPESLGAPGVQPDAIQVQPVAQGYSYLLEYHLDQVDDIMSKVRKGLLELNLPLRSIEDELAPSQMETTFDVMEGLEAADAALLIKSAIKQICSRHGYHATFMCKPAINGFSVASGWHMHQSLVDKDTRKNLFIPSEGEVVSPLGRAYAGGLLANGSAASSFTTPTVNGYRRRQPHSLAPDRRAWAKENKAAMVRVISATGDPASRIENRIGEPGANPYLYMASQIVSGLDGIKIKRDPGGLQGAPYGAQVPMLPTALAEALDALEHDSELFRSCFGDTFIKYWLQLRRSEWARFLDAEGAEAAEPTGAVTQWEQKEYFNLL", "function": "Involved in the initial oxidation of aniline to catechol by the release of its amino group. Catalyzes the ATP-dependent ligation of L-glutamate to aniline to yield gamma-glutamylanilide. AtdA1 has a broad substrate range and is able to convert the following anilines: aniline (100%), o-chloroaniline (92%), m-chloroaniline (69%), p-chloroaniline (92%), o-methylaniline (40%), m-methylaniline (27%), and p-methylaniline (45%). It can also accept chlorinated and methylated forms of aniline, preferably in the o- and p-positions.", "AFDB_id": "AF-Q44249-F1-model_v4" }, { "swissprot_id": "A0A0U1LQE2", "sequence": "MLKTVLITGCSHGGLGAAMAKIYHAKGFQVFATVRNKAKVGSLGGIDGIEIMELEVTSVESIRQCANTVAKRTGGTLDILVNNAGVNAIVPLLDASLDDAKKVYDANVWSVVAMAQAFAPMLIKAKGTMCNISSVSGEMVFAWAGVYSSSRSAGTRISETLRLELAPLGVRVVTVILGGVQTSGNDPSNIADLELPSSSYYQKITAVIDLHKKTMVHPNKQNVDVAAENVVNDLLNGRGIFIRRGQASTLSWLFNTFLPYRLFTYLINRESALDKIGFRGDTE", "function": "Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of the mycotoxin cyclochlorotine, a hepatotoxic and carcinogenic cyclic chlorinated pentapeptide. Cyclochlorotine is formed by the nonproteinogenic amino acids L-2-aminobutyrate (2Abu), L-beta-phenylalanine (beta-Phe), the unique L-cis-3,4-dichloroproline Pro(Cl(2)) and two L-serines (Ser). The condensation of the 5 building blocks is performed by the cyclochlorotine synthetase cctN, a nonribosomal peptide synthetase. The assembled linear pentapeptide is then assumed to be released through cyclization by the terminal condensation-like domain of cctN. Incorporation of the alternative substrates allo-threonine or alanine by the domains A3 or A1 respectively may lead to the production of the variants hydroxy-cyclochlorotine and deoxy-cyclochlorotine, respectively. CctP probably acts as a phenylalanine aminomutase and provides the uncommon building block beta-Phe. Furthermore, 2Abu can be synthesized from threonine by one of the threonine dehydratases and transaminases localized outside of the cluster. The biosynthesis of the unusual dichloroproline moiety remains elusive since the actual halogenase still awaits to be detected, with the possibility that proline halogenation is accomplished by a so far unknown type of halogenase. Finally, the cluster encoded transporters cctQ and cctS are most likely responsible for cyclochlorotine secretion and thereby may contribute to intrinsic resistance. The functions of the remaining proteins encoded by the cluster (cctM, cctO, cctR and cctG) have not been identified yet.", "AFDB_id": "AF-A0A0U1LQE2-F1-model_v4" }, { "swissprot_id": "Q95Q39", "sequence": "MTITRILTCLLICLFIRIPAAGTKTTQLIFKRFTEETCQNDPCLNGGTCTPGKLSCTCATGWMGRYCHRKCRNIYKSCDRWAVEDKCHTILTQTNFFDVNCAISCKMCSPDPNYVAPEIPLAPALEPMQFFLGKWHSRASKGLRFPTDLYDTEYEEIIDIAPANVPMFGPPSLNFTSTSWFGDDTRVVHGFITLKPNSFPPEVAILSTSNEGLNMIELGTLKHHVLTLNVSYMQVHPTMDSKVLPLGATRRLRRVGSLLEMTVAKLFSENKVSQFKKMFKKIADYAF", "function": "Plays an important role in determining body shape and sensory ray morphology, possibly by acting as a signaling molecule outside the expressing cell.", "AFDB_id": "AF-Q95Q39-F1-model_v4" }, { "swissprot_id": "Q8INK9", "sequence": "MFALSARHALRRTRIFAIPRFFADSRQDSDNPDKRYSGPAATMDNKSEKVTVNKEELRKRLTPVQYQVTQEAGTERPFTGCYNKHYEKGVYQCIVCHQDLFSSETKYDSGCGWPAFNDVLDKGKVTLHRDASIPGGNILLLIAHPERIRTEVRCARCNAHMGHVFEDGPKPTRKRYCINSASIEFVNADPATSSPPVATPTAAPIAQQ", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization.", "AFDB_id": "AF-Q8INK9-F1-model_v4" }, { "swissprot_id": "Q08199", "sequence": "MVRILPIILSALSSKLVASTILHSSIHSVPSGGEIISAEDLKELEISGNSICVDNRCYPKIFEPRHDWQPILPGQELPGGLDIRINMDTGLKEAKLNDEKNVGDNGSHELIVSSEDMKASPGDYEFSSDFKEMRNIIDSNPTLSSQDIARLEDSFDRIMEFAHDYKHGYKIITHEFALLANLSLNENLPLTLRELSTRVITSCLRNNPPVVEFINESFPNFKSKIMAALSNLNDSNHRSSNILIKRYLSILNELPVTSEDLPIYSTVVLQNVYERNNKDKQLQIKVLELISKILKADMYENDDTNLILFKRNAENWSSNLQEWANEFQEMVQNKSIDELHTRTFFDTLYNLKKIFKSDITINKGFLNWLAQQCKARQSNLDNGLQERDTEQDSFDKKLIDSRHLIFGNPMAHRIKNFRDEL", "function": "Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2.", "AFDB_id": "AF-Q08199-F1-model_v4" }, { "swissprot_id": "Q9BKZ9", "sequence": "MREGTPRVRIEVNKGSNRPSQFVSESEEQRLQRVQSRDSDTATMNFVTDDRMMEEHDEYSAFKEAYEEEESREYVIENGVKRLVNQHYDSRGYSSAGRGQKGRREEERRRNMAVDYSSQDFRQSLAAIDQASRDGAISRGEDGVRVRQIGDTTIMTEHRDPYSFYWQLDQARREAESPPRRPPPTDYVIDEEEEVLETVYSPEADDVMFENQYRRPVRHPLPPPPPIMEEEPKDLPPGWEKHEDPQGYSYYWHVDSGTIQRQPPPPVNRETQADAPPPQIIQLPPQQPVIEEHAFKQTTTKRRIEQDEMSEREIEDVAMIENGDTYHKPVRFAVRSLGWTDISEDELTAEKSSRAVNRAIVDLTTRSDIDSIPKWGDGRELIMELDDNELALLDPDSMNVIHSERIQAIRVWGVGRDNGRDFAYVSRDRGTRRFMCHVFRCDTSAKTIANTLRDICKRLMLHRRPSSLHAIESGEKRIVRSEGLTAPIDEPRKVIRCHFLGVTQVPKATGIEILNEAVDRLVSQVRSERWILADVSIAPSTIAIVEVNGQQIAECRVRYLSFLGIGRDVKHCAFIMQTSSESFMCYVFHVEPNAAAMAKMVEAACKLRYQKVLDAHSSSRHHSGMSIHGQHPPSTYHGKGWTETFRDAFGSVTSRMVPSRSAQRL", "function": "Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2.", "AFDB_id": "AF-Q9BKZ9-F1-model_v4" }, { "swissprot_id": "Q9VHP4", "sequence": "MLASIILSGWLLLAWLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQMMNPETFLQYMDGLSRQFKAPFISWMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLLEPIVSVVAANSNPDQQRSEMEMRGKSKAIFIEQVREHVERGQLSWQDVRDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDINLEQLQRLEYTEMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNISLKLKDYPLCRVERR", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9VHP4-F1-model_v4" }, { "swissprot_id": "Q6MPB8", "sequence": "MKKTTRSKYRQEFSGDHVFDYKDPASLTRFIGDGGKITPSRISKLSVAQQKRVAAAVKKSRNLALLPSGSDSYDTFHRAEAISPVPFEI", "function": "Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.", "AFDB_id": "AF-Q6MPB8-F1-model_v4" }, { "swissprot_id": "Q8L5Y9", "sequence": "MAGQEDEYDPILDNKREAEAKSQVSVAADKNMAPSTSGTPIHRSGSRPQLDLSKAEIQGNLEERDPTILLPNQSDDISHLALDIGGSLIKLLYFSRHEDYSNDDDKRKRTIKERLGITNGNLRSYPVLGGRLHFVKFETHKINECLDFIHSKQLHRRDPYPWSSKTLPLGTGVIKVTGGGAFKFADLFKERLGVSIEKEDEMHCLVSGANFLLKAIRHEAFTHMEGEKEFVQIDPNDLYPYLLVNVGSGVSIIKVDGEGKFERVSGTNVGGGTYWGLGRLLTKCKSFDELLELSQKGDNSAIDMLVGDIYGGMDYSKIGLSASTIASSFGKAISENKELDDYRPEDISLSLLRMISYNIGQISYLNALRFGLKRIFFGGFFIRGHAYTMDTISFAVHFWSKGEMQAMFLRHEGFLGALGAFMSYEKHGLDDLMSHQLVERFPMGAPYTGGNIHGPPLGDLDEKISWMEKFVRRGTEITAPVPMTPSKTTGLGGFEVPSSRGSALRSDASALNVGVLHLVPTLEVFPLLADPKTYEPNTIDLSDQGEREYWLKVLSEHLPDLVDTAVASEGGTEDAKRRGDAFARAFSAHLARLMEEPAAYGKLGLANLLELREECLREFQFVDAYRSIKQRENEASLAVLPDLLEELDSMSEEARLLTLIEGVLAANIFDWGSRACVDLYHKGTIIEIYRMSRNKMQRPWRVDDFDAFKERMLGSGGKQPHRHKRALLFVDNSGADVILGMLPLAREFLRRGTEVVLVANSLPALNDVTAMELPDIVAGAAKHCDILRRAAEMGGLLVDAMVNPGDGSKKDSTSAPLMVVENGCGSPCIDLRQVSSELAAAAKDADLVVLEGMGRALHTNFNAQFQCEALKLAMVKNQRLAEKLIKGNIYDCVCRYEPPSL", "function": "Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK1. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'-phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein.", "AFDB_id": "AF-Q8L5Y9-F1-model_v4" }, { "swissprot_id": "Q9VVH3", "sequence": "MVLGFLVRGGLVAATVYYTQKVGIWGDSDQTDKLYNDIKSELRPHVQKLEKQLPFEVPQLPKTGEMRFLAKHYYNEGVKNTFRFIHMLPCYAGRGLKKVKDTFQDFAQSPAIAGGAESSPPK", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.", "AFDB_id": "AF-Q9VVH3-F1-model_v4" }, { "swissprot_id": "Q9W1X9", "sequence": "MDSPLNDGSHHPPPHAPHPLADYQFSAEEVKALRECNTESFFQRSLPFGTGLGLLAYFGVKNGYLQGHVKYGAVPKVVMGVILGYFVGKFSYQQKCAEKIMRLPNSHLGELLRQRRQGGGVISSITPDENLGRAFTLAPFSPSSADVYSDEAYQPGRSTSLNLDTESRPTLSGLDDIYRPTLDSGSMLEAELPLEPSKPGQSYEDLRRRNREEYSKHQQSPYSRPYEPPVAVQQRPVEQAQSEPAGRKNQYGDSWTD", "function": "Maintains stem cell potency. Involved in endocytic pathways that mediate signaling during hematopoiesis.", "AFDB_id": "AF-Q9W1X9-F1-model_v4" }, { "swissprot_id": "A4QFW4", "sequence": "MTVNISYLTDMDGVLIKEGEMIPGADRFLQSLTDNNVEFMVLTNNSIFTPRDLSARLKTSGLDIPPERIWTSATATAHFLKSQVKEGTAYVVGESGLTTALHTAGWILTDANPEFVVLGETRTYSFEAITTAINLILGGARFICTNPDVTGPSPSGILPATGSVAALITAATGAEPYYIGKPNPVMMRSALNTIGAHSEHTVMIGDRMDTDVKSGLEAGLSTVLVRSGISDDAEIRRYPFRPTHVINSIADLADCWDDPFGDGAFHVPDEQQFTD", "function": "Catalyzes dephosphorylation of dihydroxyacetone phosphate (DHAP) to produce 1,3-dihydroxyacetone (DHA). Is the main enzyme responsible for DHA production from catabolism of sugars (glucose, fructose, and sucrose) in C.glutamicum. Displays no activity toward nucleoside monophosphates (AMP, CMP, GMP, or UMP).", "AFDB_id": "AF-A4QFW4-F1-model_v4" }, { "swissprot_id": "P18269", "sequence": "MSRRVFASAVLLLIVVTMCCGGAATAQVGSNADASTPGSALTGAIAGEGSSSGGVEGLQRVDLFVPQKTQVLPKKGPDSSRRDSFFSPSLVSAGGVIAAFAEGHINTKNPHNESAKPFSDVVAGYIDSAWEWPTLVEKVSESTWQAHTVLGKAEGKKSLDVVLRPTTTTKGNKVFLLAGSTDLSYVNWSWREGSLELKLVVGDVTKPTSSEPTERIKWGEIKSLLNESTIAAQKGKLTEFLASGGSGVVMEDGTIVFSLMAVNEKKDGVFSLIIYSKDNGSTWSLSEGISPAKCGAPRITEWEGSLLMIVDCENDQRVYVSRDMGTTWTEAIGTLSGVGSTHNWETIGRRLAVEALITVTIEGRKVMLYTQRGYALGETETTSPLYLWVTDNNRSFFVGPVGMDNAVKGELAGALLYSDGGLHLLQRRDSGEDSVMSLSRLTEELKEIKSVLSTWSQKDVFFSSLSIPTVGLVAVLSDAAGDGRWYDEYLCLNATVTNATKVKDGFQLTEPDSRAVWSVNIPDGNVRHISLSHNFTLVASVIIEEAPSGNTPLLTAVLVDAGPEYFMRLSYTADNKWMTMLKDEKKPTTESRPWEAGKEHQVALMLQGNKASVYVDGELLGEEEVPLTGEKPLEIFAFCFGACKIDGDEEESSPKEIGKKPRVTVTNVFLYNRPLNSTEMRAIKDRIPVPTRAPEPQVKIAPKPAAPAAPAGNEETARETGDGGANGDAVSAYGRVLLPLLFLLGLWGLATA", "function": "Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.", "AFDB_id": "AF-P18269-F1-model_v4" }, { "swissprot_id": "A0M2C1", "sequence": "MFGDMMGMMNKLKEAQEKVEATKKRLDTVLVDEQSSDGLLKITITANREVKNISIDDKLLEDKEQLEDYLVLTMNKAIEKATNINEAEIGAAAKDGMPDIPGMDGLMK", "function": "Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.", "AFDB_id": "AF-A0M2C1-F1-model_v4" }, { "swissprot_id": "B0R6I5", "sequence": "MHSTTRREWLGAIGATAATGLAGCAGVGGAGQPVTVGSLLPLSGPGSLGALAADHQRAIDTAVEHANRGGGINGRDVVHVSKDTEADPSVAADRYATLAADESPLAIVGPVLSGVTTALTEQAAADAQLLVSPSTTAPAIATAGRSDGQKFVARTCPNDSQQAAVMAKIVDDDMYAAADTATILYVDNAFGAALADVLADRLGADLLASVPYQGGTDTPGGPVDDALAPDPDAVAFIGSPGSSSGVIDELVGREYGGEIALSSALASASSPPSWNGAYTATVNSASTVGTKRLRRALSDATPLQPYTENAYDAAALALLAASYSGDPTPRAVAGALQSVSGGVGHSITVGDFGRATDLIDAGRELNYNGATGNVDLTAALEPVTGYLIQQLTDAGIETRELLKSGYFTDGGDA", "function": "Mediates chemotaxis towards five attractant amino acids (leucine, isoleucine, valine, methionine and cysteine). May function as a receptor that binds the amino acids and transduces a signal to BasT. Has probably no additional role in transport.", "AFDB_id": "AF-B0R6I5-F1-model_v4" }, { "swissprot_id": "Q4QTJ1", "sequence": "MSKLITTEPLKSMAEVISNYVIQRESFSARNILNKNSLVKKEIRYDLEVPTSADSIWSVYSCPDIPRLLRDVLLPGVFQKLDVIEGNGGVGTVLDIVFPPGAVPRSYKEKFVNINHEKRLKEVIMIEGGYLDMGCTFYMDRIHIFEKTPNSCVIESSIIYEVKEEYAGKMAKLITTEPLESMAEVISGYVLKKRLQVFGFEIKPKLRFNLLLCLIICLVIAGGMFVAGVPL", "function": "Involved in the biosynthesis of (S)-coclaurine, the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or papaverine. Condenses dopamine and 4-hydroxyphenylacetaldehyde.", "AFDB_id": "AF-Q4QTJ1-F1-model_v4" }, { "swissprot_id": "Q96316", "sequence": "MGSTVAAALLLFLAAVPAVFAATFKVGDISGWTSNLDYTVWLTGKTFRVGDTLEFVYGLSHSVSVVDKAGYDNCDSSGATQNFADGDTKIDLTTVGTMHFLCPTFGHCKNGMKLAVPVLAAAPSPSTPSSPPSTPSTPSSPPSTPSTPSSPPSPPSPPSPSLPPSSLPPSASPPTNGTPDSETLTPPPAPLPPSLSPNAASKGVMSYGIIGVTMILMYAVMT", "function": "Probably acts as an electron carrier involved in oxygen activation and/or lignin formation.", "AFDB_id": "AF-Q96316-F1-model_v4" }, { "swissprot_id": "P17200", "sequence": "MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTESVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR", "function": "The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. May couple to multiple functional responses in cell lines.", "AFDB_id": "AF-P17200-F1-model_v4" }, { "swissprot_id": "Q8BLI4", "sequence": "MRTHTRGAPSVFFICLLCCVSAFITDENPEVMIPFTNANYDSHPMLYFSRKDVAELQLRAASSHEHIAARLTEAVHTMLTNPLEYLPPWDPKEYSARWNEIYGNNLGALAMFCVLYPENTEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQETFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLILMNQGYLQEAYLWTKQVLSIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFDINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKPVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTYFNNVLMFSPAVSKSCFSPWEGQVTEDCSSKWSKYKHDLAASCQGRVIAADEKDGVVFIRGEGVGAYNPMLNLKHIQRNLILLHPQLLLLVDQIHLGEESPLETAASFFHNVDVPFEETVVDGVHGALIRQRDGLYKMYWMDDTGYSEKANFASVMYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSVDVQSFSIHGDPQRLDVFIATSEHAYATYLWTGENTGHSAFAQVIADHQKILFDQSSAIKSTAVPEVKDYAAIVEQNLQHFKPVFQLLEKQILSRVQNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQRQQRGKSKKSRKAGKHYKFVDAVPDIFAQIEVNEKKIRQKAQVLAQREQPIDEDEEMKDLLDFADVTYEKHKNEGSVKGGFGQVRMVTSHNRAPSLSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCVLLWLYSSCSQSQC", "function": "Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.", "AFDB_id": "AF-Q8BLI4-F1-model_v4" }, { "swissprot_id": "Q661D6", "sequence": "MGQKVHPYSLRVKINKDWKSKWYFDKKLYSTILHEDFLIRLEIMKFLKGIKFDISDIEIIRNNPQKVTVVIVTPRPGSVIGLKGSNLEKIGQLLTKKISKKISIKIKEVKRPELDAQIIANGIAKQVENRVSYRKVLKSSLSTSMLKGAQGLKIKIAGRLGGAEIARSFEVKEGRVPLHTLRANIDYGFSEAQTTYGIIGVKVWLFKGEVLGRQTNSDAGQVINKKPFRERGESVKNFDKILNNREKANERQSRAALNKKDGLSKDETGLLNKLGSSFSKERIDSNEQNIGG", "function": "Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.", "AFDB_id": "AF-Q661D6-F1-model_v4" }, { "swissprot_id": "Q8XX54", "sequence": "MQITVVGAGIVGISTAYALAQEGHQVTLVERNPGPGEGTSYANGGQLSYSYVAPLAGPGVLSHVPGWLLRRDSPLRLKPSLDPVLLRWGLRFIAACNRERADRTTRELLALSFYSRARMEALRAASPDLSFSFARRGKLVVYRDAAAFASARAQVGYQATLGCEQHALSADETIAREPALAGARGAIVGAIYTPDEDVADCHQLCVGLFNRLCALPNVALRFNAGAESLWVEGRRVRGVRTAHEPITADAVVVAAGVASAGLLGPLRIDPGLYPLKGYSISLPLGEGGAGSDGAPVVSVTDAARKIVYARIGRTLRVAGMADLVGWSDRLDPRRVQTLYDETRALFPAALRASDAGADAAPWAGMRPATPTGVPVVGPSPVDGLWLNVGHGALGFTLAMGSAGLLADLIARRAPAIAAAPYALAR", "function": "Oxidative deamination of D-amino acids.", "AFDB_id": "AF-Q8XX54-F1-model_v4" }, { "swissprot_id": "Q19821", "sequence": "MFSSEGKFRKTYRHQFNQLRTGDETEIPMSTLASRIETRKIPLTNGQIHAIKEAPDELVDIDGFQKIVTSKAAQRSTIKRIMYDMADPIMSDSQKIEVHSYIDSYSWCPPPIFMLLITIIQVGIFFFYWESDGGRSIWTDCAGCFVHHNHTAPGIFIFAPKLRGEAWRFTSYMFLHAGLNHLLGNVIIQLLVGIPLEVAHKIWRIGPIYLLAVTSGSLLQYAIDPNSLLVGASAGVYALIFAHVANVILNWHEMPLRWIRVLVLFVFIFLDFGGAIHRRFYTNDCDSVSHLAHIAGAVTGLFFGYVVLYNVVEHRIEKIIRYVCLFLYSAFFATTIIFVIVRQPYSKNLWNNENCS", "function": "Serine protease which activates lin-3 isoform a in the proximal vulva precursor cells (VPC) during vulva development to transmit the inductive anchor cell signal to the distal VPCs.", "AFDB_id": "AF-Q19821-F1-model_v4" }, { "swissprot_id": "Q6L0W5", "sequence": "MISYDKSLNYFSLYYRSNHLIMPDLISKREIGYIPFSGTMIRHLSFRNHREIESFVKRNTPRHLYYSSAYYIKPDEKRMEKKIWEGAELIFDLDADHIPGSDKMTYEEILLEVKKHVSRLLNYLINDFGFDDDSIKLYFSGGRGYHVHVVSDRVYSLDSDARREIGNYIKMEDFTIDNIIRASREKPESGPLKRFNEYISEIYSDENYLKRFYNGDFDRYYKSLDVYKDGKKKIDIMRENNYEKFKIVSKRDLDVLNNILNDFKDKYSAEIDEPVTTDVHRLIRFPGSLHGKTGLAVTPVNINEFDNFDPLISAVPEVFKDKYEHVYLNSDYMITMMNEKFSLNAGENKVPLYLALFLTGMKIGNFIEKK", "function": "Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.", "AFDB_id": "AF-Q6L0W5-F1-model_v4" }, { "swissprot_id": "Q1L908", "sequence": "MSGACREVVTLQLGHYSNFIGTHWWNLQDAGLVYDADVPAGELQSDVLFREGLTLAGHVTYTPRLIAIDLKGSLQTLRKEGSLYDTENENSAFTWDGQIMTHQESPPSKNSFLQELDNLDTGGVLAESDFNHLTSSVDNCSVPGASVAVETINSSLERIQKSYRLEGSVRVWSDFLRLHLHPRTISVINQYNHDGESERLEVFGQGEALLQGQVLEDLEDRLHFFIEECDYLQGFQVLCDLTDGFSGLGSKVTEYLQDSYGGRGILTWGVAPVNHPDTSSMKDLYHMMNCALGTLQMANHSSLFCPLTLRGGLCRRPPPPTAFPLLNCDPLLWYHSSSVLALALDALTVSYRMRHCSATMWQLSDALTTSGRKVVSAYGSVPFPMMLGGCLPDALDAFSNAVPWRSLSACPEISDRRFCFSQSVTLKGVDEQSLVSRLLPGMEAPSPLHYERSGEDVLSAYVRSHYPSSPLAVQLVSSGSKVTPPFPQIFSPSLSAQGFLQSHSTPASPSCPPVSCLPVLTSLQSSPAVGLQLSELQRACASLDLRRVAPSFLTHGPEHAEISEYLEQLRNLAHCYRQSHSRSSSEEDDDD", "function": "Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.", "AFDB_id": "AF-Q1L908-F1-model_v4" }, { "swissprot_id": "Q9W4V8", "sequence": "MSMSMAPATVLQLLRGLSTPRLLTHIHQHRALGNHYHHYHQHYQHQHHLLHHQQQYLRLFTCTALPAAAPALFSILHTARGYSSTTKQEAGATGPNDAPEVAPNAPLLAKLFPQTSPEVDSNAEQERKKREEEEEKENERAWKRMKLGFAIFGGSAVAAGFWAVYEFGKPEVDPNGQPIEDEFTHKPLVQQYLQRMWKSIHYYQRMIQEPSRAKLLPDPLKPPYVQPRYTLVLEMKDVLVHPDWTYQTGWRFKKRPGVDHFLAECAKDFEIVVFTAEQGMTVFPILDALDPNGYIMYRLVRDATHFVDGHHVKNLDNLNRDLKKVIVVDWDANATKMHPDNTFGLARWHGNDDDGQLLDLIAFLKIIAQNNVDDVREVLHYYRQFDDPINQFRENQRKLAEQMLEAERIEQSKTKPMVKQWSRNILGR", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.", "AFDB_id": "AF-Q9W4V8-F1-model_v4" }, { "swissprot_id": "A0R4Z6", "sequence": "MAPDTPSQPASRRDELLQLAATMFADRGLKATTVRDIADSAGILSGSLYHHFKSKEQMVEEVLRDFLDWLFGRYQQILDTATSPLEKLTGLFMASFEAIEHRHAQVVIYQDEAKRLSDLPQFDFVETRNKEQRKMWVDILQEGVADGSFRPDLDVDLVYRFIRDTTWVSVRWYKPGGPLSAEQVGQQYLAIVLGGITQSQGDKHA", "function": "Controls the expression of a small regulon that may play a role in the utilization of cholesterol.", "AFDB_id": "AF-A0R4Z6-F1-model_v4" }, { "swissprot_id": "Q6CG53", "sequence": "MSSSLYRVLRNAWEVGPRSYWKQLNSIGDTKSGRLVGTDIYGNKFYETDHQDEIHLRTRYVEYKEKDYDMSQVEPGWHFWLGYGVDTAPCNTPKEKLPIRAYPYKFQPNYTGTPGAFVTYNTLKPKISAWEPVTKQRS", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.", "AFDB_id": "AF-Q6CG53-F1-model_v4" }, { "swissprot_id": "O43292", "sequence": "MGLLSDPVRRRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTMVEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFSRKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLYLLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEPGGAPGPSVPLPPSQGVGLASLVAPLLISQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGPRTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEHHTYGALLFPLLSLGLYPCWLLFWNVLFWK", "function": "Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.", "AFDB_id": "AF-O43292-F1-model_v4" }, { "swissprot_id": "B2HIL4", "sequence": "MIMDTNAVSFRARDEVTTQLAPGTGGQAVPTSNGMMTRFAMSESSLTDLLHKAATQYPNRAAYKFIDYDVNPDGFTETLTWWQIYRRAKIVAEELRGYGASGDRVAVLAPQGLEYIIAFLGVLEAGLIAVPLPVPQFGIHDERISAALQDSTPSVILTTSPVIDEVTKYAPHARAGQGGTPIVVAVDLLDLDSARELDLTPPAHSSTAYLQYTSGSTRSPAGVVLSHKNVITNCVQLMSDYLGETEKVPSTAVSWLPFYHDMGLMLGIILPMINQDTAVLLNPMAFLQRPARWMQLMGKFRGQISCAPNFGFELAVRRTSDEDMAGLDLGHVRGIGSGAERVNPATLQRFIDRFAPFNLRDTAIRPSYGLAEATVFVATAEPGRPPRSVNFDYQSLSVGRVERCANEADDGAKLVSYGSSWTSEVRIVDPEARTECPAGTVGEIWVQGDNVAMGYWRNPQLTERTFDAKLTDPSPGTSIGPWLRTGDLGVMFEGELFITGRIKDLLIVDGSNHYPDDIESTIQEITGGRVVAIAVPDADGEKLVTIVEFASWGHSGQEAIDKLRSVKREITSAISRAHRVRVADVVLVATGSIPVTTSGKVRRSSCAERYRNDGFTRLDRSA", "function": "Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phenolphthiocerol, which is an important intermediate in the biosynthesis of phenolic glycolipid (PGL), also called mycosid B.", "AFDB_id": "AF-B2HIL4-F1-model_v4" }, { "swissprot_id": "P58955", "sequence": "MFDWVGLLLKVLYYYGQIIGLINFEIDWQRGRVVAAQRGILFAIAINVLICMVLLLQISKKFNLDVYFGRANQLHQYVIIVMVSLRMASGISAILNRWRQRAQLMRLVECVLRLFLKKPHVKQMSRWAILVKFSVGVVSNFLQMAISMESLDRLGFNEFVGMASDFWMSAIINMAISQHYLVILFVRAYYHLLKTEVRQAIHESQMLSEIYPRRAAFMTKCCYLADRIDNIAKLQNQLQSIVTQLNQVFGIQGIMVYGGYYIFSVATTYITYSLAINGIEELHLSVRAAALVFSWFLFYYTSAILNLFVMLKLFDDHKEMERILEERTLFTSALDVRLEQSFESIQLQLIRNPLKIEVLDIFTITRSSSAAMIGSIITNSIFLIQYDMEYF", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.", "AFDB_id": "AF-P58955-F1-model_v4" }, { "swissprot_id": "P91758", "sequence": "MLLKLIVALSLTLTLASATSDPKGWFCSFECNDWNQLEMACQKEKDCFEKTNNQFTNETVACMQPCWDLGIPCRTQCYKVYDQCTSDCPYTVPNPYECFTTCFKEAFAEVKPQIPKANLDE", "function": "Interacts with the p75 low-affinity neurotrophin receptor. Evokes neurite outgrowth and modulated calcium currents in pedal motor neurons. May be involved in target-derived trophic support for motor neurons.", "AFDB_id": "AF-P91758-F1-model_v4" }, { "swissprot_id": "Q6XGD5", "sequence": "MGIPESQLDTWSHQGSIAQSASTYSIIKNALESANTKYHGKNFKVFLQGSYGNDTNIYAESDVDVVICLDDVYYSDLTQLSPEDKDAYDRAFVPATYSYTQFKQDVLEALTERFGSDVKVGDKAIVVAANGSRRKADVIASMQFRRYWKFKGHYDSQYDEGICFFNGAGERIANYPKQHSENLTLKHQASNKWLKPMVRVLKNLRSKLIADGKLKSGLAPSYYLEGLLYNVPNEKFGTSYADCFVNAMNWIQTEADKDKLVCANEQYYLLWEGTHTSWEKADAEAFIDAAIKMWNEW", "function": "Cyclic dinucleotide synthase that catalyzes the synthesis of 3',3'-cyclic UMP-AMP (cUMP-AMP) from UTP and ATP, a second messenger for cell signal transduction. Controls the activity of cUAMP-activated phospholipase CapE, a patatin-like lipase that is a direct cUMP-AMP receptor encoded in the cdnE operon.", "AFDB_id": "AF-Q6XGD5-F1-model_v4" }, { "swissprot_id": "Q6C5G5", "sequence": "MSGNNSPINAQLFPDARDVTKDALQTFVELPECTYMKGLGSSQQAEVMACDCKPGPTACDEDSGCINRLTSIECVRCCKGCQNKRFQGKKYASVDVISTEKKGFGLRATKDIAAGEFVYEYVGEVIDEPTFKERTAIYTTQGVKHFYFMMLQKGEFIDATAKGGLGRFCNHSCAPNGHVEKWVVGKRLRMGIFASRHIQRGEEVTFDYNVDRYGAEAQACYCGEKNCVGFLGGKTQTESASKVSGTLTAALGLTSRDINAILRGKKSAEDLRPRDLTVQDVSKVMASLMMNQEAWQVNLMLQRIALCTDTSVQAAVMKMHGYQIFAQILTATWGDNPLGLDDSDRVNVTLMLLRVLQKWPRITKNKISSSQIENVVKSLTSNDNSDIATIAQELLSEWANLKMAFRIPRRKIDPDGDEHSVSRGTSEEVTKESSKSEEPNDVEVVKVNKKADNNGNGVTDSPSTRSESPFTFIPTPYSNKTAPKGPKKAVKQPASPMVPPRSLPKGWQFANDPQGKVYYYNLELNIQQWDFPKASRASSPSTPKGPKGPKGPRGNRRDERRDNSETREPLSLQSQRESDLQRIIEQARLQEVKNNSEPAPSASAKPVNAQAHRLTKLLAKVVPNQVSKYDVDRERAKKCSKDIVQILVDKELKRPEPMTEISDEKAKKIKEFVKGYMGKVVKRLEEKEGGAKDFGRGRQGNRRDSERQSDRRGRQGQSDRDHSDNHGRKRKGEENQPYEAGPMYDDESAETSTETVKKPKVDMEIDLE", "function": "Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.", "AFDB_id": "AF-Q6C5G5-F1-model_v4" }, { "swissprot_id": "Q9LMH6", "sequence": "MYSRRELEDLEYRYYSEMKDGTRKVKISESLFRCPFCYIDRKRDYQFDDLLRHASGIGGSSRTKDGRDKARHLALERYMRKYLRPRERPRPSPTSDVSSLPKEEFTGKWKSTLSTTEEGEFITTENSSSPHIVKAEPKFVSGDDSGRSGEERLKFSDKPDPFFSNEDKSYPAKRPCLVSGAKEGDEPVQRIGLSHGASFAPTYPQKLVSLGAGNGDQMYVHPWKGILANMKRTFNEKTRKYAGESGSKIREDLIKKGFNPHKVTPLWNGRLGFTGFAIVDFGKEWEGFRNATMFDKHFEVSQCGKRDHDLTRDPGDKLYGWVAKQDDYYSRTAIGDHLRKQGDLKSVSGKEAEDQRKTFTLVSNLENTLVTKSDNLQQMESIYKQTSSVLEKRMKEKDEMINTHNEKMSIMQQTARDYLASIYEEHEKASQHLEAQRKEYEDRENYLDKCQAKNKTERRKLQWQKHKNLMATQEQNKADEDMMRLAEQQQREKDELRKQVRELEEKIDAEQALELEIERMRGDLQVMGHMQEGEGEDSKIKEMIEKTKEELKEKEEDWEYQESLYQTLVVKHGYTNDELQDARKALIRSMRELTTRAYIGVKRMGALDETPFKKVAKEKYPAVEADKKAEELCSLWEEHLGDSAWHPIKVVEKDGIAKEELNEEDEKLQELRKELGEEVYAAVTQALKERNEYNGSGRYIVPELWNFKQNRKASIKEGVVYLVNSWKQKKPKPKRR", "function": "Acts in association with FDM3 and FDM5 for RNA-directed DNA methylation (RdDM).", "AFDB_id": "AF-Q9LMH6-F1-model_v4" }, { "swissprot_id": "F4IJ79", "sequence": "MTIFNWVQKKLHQNVIKEIDGVRKNEKKKRNEGISEIEKNTKAILDQVGLVDALDNWFDGVLTIGTFGFDTLNFKEEDEMDDDECGSGDLDYVVIDGSIIKNVDQESDPLISVENKFYDHHEDVGNLYVQADTDHFGSIKTAETPAVTAAAEAEIEPQKKRTTLAELFMEDHDKGYDTWHCKKPNNPNLDGEEVKYYKQNGSKLSKRFSFVKKKLVMSKSKEEENDLRPIKKMRQMIKRMLKKKIHPDVDATKALKKDVPYKPTRNCEALESHYLLKIQDCVA", "function": "Involved in the regulation of inflorescence branch growth angle. Promotes horizontal inflorescence branch growth.", "AFDB_id": "AF-F4IJ79-F1-model_v4" }, { "swissprot_id": "P25345", "sequence": "MFHAFTFLKGGRFYSSLTVKSLYEQVHHTSHDPISINGWIKSIRLLKRIAFLDLQDGTSVNPLRIVIPLTNTDEVQFLKILKTGQTLSISNATWQSTPNRKQPFELQIKNPVKSIKLVGPVSENYPLQKKYQTLRYLRSLPTLKYRTAYLSAILRLRSFVEFQFMLYFQKNHFTKVSPPILTSNDCEGAGELFQVSTNTSPTASSYFGKPTYLTVSTQLHLEILALSLSRCWTLSPCFRAEKSDTPRHLSEFWMLEVEMCFVNSVNELTSFVETTIKHIIKACIDNQQELLPKQFISSQENNASSELSINQETQQIKTRWEDLINEKWHNITYTNAIEILKKRHNEVSHFKYEPKWGQPLQTEHEKFLAGEYFKSPVFVTDYPRLCKPFYMKQNSTPDDTVGCFDLLVPGMGEIIGGSLREDDYDKLCREMKARGMNRSGELDWYVSLRKEGSAPHGGFGLGFERFISYLYGNHNIKDAIPFYRTSAESIDF", "function": "Catalyzes the attachment of asparagine to tRNA(Asn) in the mitochondrion.", "AFDB_id": "AF-P25345-F1-model_v4" }, { "swissprot_id": "Q86XE3", "sequence": "MAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCYQLYGDPRAGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVAIGRTDIEDLDLYATSRERRFRLFASIECEGQLFMTPYDFILAVTTDEPKVAKTWKSLSKQELNQMLAETPPVWKGSSKLFRNLKEKGVISYTEYLFLLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKREIKGDEEKRAMLRLQLYGYHSPTNSVLKTDAEELVSRSYWDTLRRNTSQALFSDLAERADDITSLVTDTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVLEIEFLSYSNGMNTISEEDFAHILLRYTNVENTSVFLENVRYSIPEEKGITFDEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLKKELHSR", "function": "May play a role in mitochondrial calcium uptake.", "AFDB_id": "AF-Q86XE3-F1-model_v4" }, { "swissprot_id": "P42334", "sequence": "MSFSELNIDAFRFINDLGKEYSMLNPVVYFLAEYMMYFLALGLVVYWLTRTTKNRLMVIYAVIAFVVAEILGKIMGSLHSNYQPFATLPNVNKLIEHEIDNSFPSDHTILFFSIGFLIFLFHKKTGWLWLVLAFAVGISRIWSGVHYPLDVAAGALLGVLSALFVFWTAPKLSFIHQMLSLYEKVEQRIVPSKNKSNDKSKNF", "function": "Part of the binding-protein-dependent transport system for bacitracin that confer resistance to this antibiotic; probably responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-P42334-F1-model_v4" }, { "swissprot_id": "D1BJD0", "sequence": "MSAEQQAVVSAEQQAVVSAEQPAVVSADQPAVTWTVVVPVKVTSQAKTRLAGDLSPTQRVELVRAMVVDTVAAARATPTVDRVVVVTDDPDVVADLSADEPAGTDAERRADPSAENRASTSAQHPCLRAHLDVVPEPSPAAGLNAAIRAGVASARSGGGLAAVSVAVLLGDLPALRPGDLGAALEAASAHHRAVVTDADGSGTTLLTARSGVELYPAFGPGSAAEHAARGHVVLDVADVPAVSGLRQDVDLARDLAAVAALGPGPRTTEVLDRWARLGEGSSAA", "function": "Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.", "AFDB_id": "AF-D1BJD0-F1-model_v4" }, { "swissprot_id": "Q9Y794", "sequence": "MSSSPFTNLGNLDTEAIYENKENEYQTNITNETSNVQNLSSGNDDQQYPNSTNDDANNGLTASQAKLQDIAAVTLFQDNNISTTTLAPPSPSPLRLNEAPRRRGRPRKYPPKPIDEGSEPIIKRKRGRPPKIKSSSPSTKLDDPLKPKRGRGRPRLHPLPVVQPSVDEGTTQNNLQMGLDEPNIIEGFAEGHANLSELKPKRGRGRPRKIKPEEGSSSQNGLSPLVVLPAKRGRGRPPLHRSEQKIANTPISNNVTVESTGTNLHTHSQLNPENEQSSSEFYSLNPQSEIRKEVVVTDQPLFSTADVPVKRKRGRPPLNKPKILFGTSTENKIDENRPKRGRGRPRLERPSGLPLDSKSQSLFKRKRGRPPKIASGIVPLSAFTRKHEDMLHDSDALSLKHFAITSPNNQQFLNNQQRESAPLLPRKRGRPPKKRQENAEIRNITPGLTDSSVHSSSATPQSESSSPNSVSPLLPSSDRLPLLRQSQFTPPPKKPNFEVAIISPKKSQHKLYPNPVVESVFNDVPYSEIDSQLHTIKSTIAARLCGKSHIPLVGHMDEQTKLYQWVRQTIVLGEGNSVIIVGPRGSGKSVLVDDILSRAAQEINEKSYVVRLNGTYQTDDKLALREISRQLSIELESIESDEALKSEMNFSDTLTKLLATLSHPVDLGIAEDVMTTSAAVIFVLEEFDLFVQHSRQMLLYNLFDIAQSRKAPILIIGLTTRYDCSESLEKRVKSRFSHMVIPMRPPSSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTRSHLHKLVQHHYFASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRFEARDIPACNFNSAYQEYRQLHQSSVINAAASGALAHSSRLWGRDVALEAWETLGSIGLIIPVHPSTNVSGALSRQCQLWQPEVDINVVSVGLREHRRLPSHYYRWLKEVI", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner. This binding is mediated by the N-terminal A.T hook repeats of orc4.", "AFDB_id": "AF-Q9Y794-F1-model_v4" }, { "swissprot_id": "W8JDE2", "sequence": "MDQLMNFSLTSPIFLLLSSLFLIILLNKLMRGNKIQKGKKLPPGPKKIAIIGNLPSNGRFTSLIVFLNNLAEKYGPIMHLRIGQLSAVIISSAEKAKEILNTHGVRVADRPQTTVAKIMLYNSLGVTFAPYGDYLKQLRQIYAMELLSPKTVKSFWTIMDDELSTMITSIKSEVGQPMILHDKMMTYLYAMLCRATVGSVCNGRETLIMAAKETSALSASIRIEDLFPSVKILPVISGLKSKLTNLLKELDIVLEDIISAREKKLLSQPQQPLMLDEEDMLGVLLKYKNGKGNDTKFRVTNNDIKAIVFELILAGTLSSAAIVEWCMSELMKNPELLKKAQDEVRQVLKGKKTISGSDVGKLEYVKMVVKESVRLHPPAPLLFPRECREEFEIDGMTIPKKSWVIINYWAIGRDPKIWPNADKFEPERFSNNNIDFYGSNFELIPFGAGRRVCPGILFGTTNVELLLAAFLFHFDWELPGGMKPEELDMNELFGAGCIRENPLCLIPSISTVVEGN", "function": "Involved in monoterpene indole alkaloids (MIAs) biosynthesis. Converts by aromatization the tetrahydro-beta-carboline alkaloids tetrahydroalstonine and ajmalicine to the corresponding beta-carboline alkaloids alstonine and serpentine, respectively.", "AFDB_id": "AF-W8JDE2-F1-model_v4" }, { "swissprot_id": "Q708S3", "sequence": "MPIEFVCKIKFAEGEEAKGASTEGGGTGMLDEGLRRQKEGMADLASFASSSSLHGLARALGTSERLGFRQTLWGLALLVSLGLFLYQATWSAATYLERPHLAALREETRRELTFPAITLCNVNRFRFSALTDADIYHLANLTGLPPKSRKGHRPSELQYPPPNMLDIFQRTGHQLEDMLKSCNFSGQNCSSEDFSVVYTRYGKCYTFNGNKTSPKRVRQGGTGNGLEMMLDIQQDEYLPIWRETNETTLEAGIRVQIHSQNEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRASSEPVIPGYDTYSVSACRLHCESTQVQRECNCRMVHMPGDADICAPSKIKCVDKALASLQKSTGDSCPCETPCNLTRYGKELSMVKIPSRGSARYLSRKYQKSEEYIRDNFLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAKNKIKQLLKPKKSQKQTNQRNLIQEQIQRTKNLREQNLKAQLTAGAIATVRFEEVKVKAANDVAQPHSAHPTSVLPNHHNAQQAVQQDFAC", "function": "Probable cation channel with high affinity for sodium.", "AFDB_id": "AF-Q708S3-F1-model_v4" }, { "swissprot_id": "A0A0A2JYK3", "sequence": "MTVDTAPQSHYQETKVSEIPIVILKSSATDDVAAHEAIEALKVAGVCIVRNLLDRSTVDKVRQELQPYDKQADSFEGFPKNYCQVAGLLSKSPTYAHSIVGNKLFTAVRNYFLTSTYECWAEKGTWMSVKSPPQLDSTLALYVNPGSGDQGLHRDDATQQNWNSGASEYSLGRDSGCAMMVALTECAREDGTTRFIPGSHLWDYQYDHPSNDDPRIRYAEMRPGDAYLMLSSVIHAGSVNYSTDRRRVLAAVFAARSHLRQVENQYLTYDIETVRTFPTWLQRFMGYSLSKLFQGWVDKKDPLLVVDPNAQPEGEDDGGMKPNEGEHVVEAQI", "function": "Dioxygenase; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals. Communesins are biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks derived from L-tryptophan. The L-tryptophan decarboxylase cnsB converts L-tryptophan to tryptamine, whereas the tryptophan dimethylallyltransferase cnsF converts L-tryptophan to 4-dimethylallyl tryptophan which is further transformed to aurantioclavine by the aurantioclavine synthase cnsA, probably aided by the catalase cnsD. The cytochrome P450 monooxygenase cnsC catalyzes the heterodimeric coupling between the two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold. The O-methyltransferase cnsE then methylates the communesin scaffold to produce communesin K, the simplest characterized communesin that contains the heptacyclic core. The dioxygenase cnsJ converts communesin K into communesin I. Acylation to introduce the hexadienyl group at position N16 of communesin I by the acyltransferase cnsK leads to the production of communesin B. The hexadienyl group is produced by the highly reducing polyketide synthase cnsI, before being hydrolytically removed from cnsI by the serine hydrolase cnsH, converted into hexadienyl-CoA by the CoA ligase cnsG, and then transferred to communesin I by cnsK. Surprisingly, cnsK may also be a promiscuous acyltransferase that can tolerate a range of acyl groups, including acetyl-, propionyl-, and butyryl-CoA, which lead to communesins A, G and H respectively. The roles of the alpha-ketoglutarate-dependent dioxygenases cnsM and cnsP have still to be determined.", "AFDB_id": "AF-A0A0A2JYK3-F1-model_v4" }, { "swissprot_id": "Q1ERH8", "sequence": "MKEEIDAPVSTDASGTDLENARDQPSGEKPTAVDIYLVEWDGPNDPELPMNFPLWKKSLITCIFSTLTIWVTFSSSVFSAAAGITSKEFHVSVEVMTLGTSLTVLGFTVGPLVWGPMSELYGRLKPLYIGYAIFIIFQVPVAVAQNLETLMLARFFLGFFGTSALAIIPGALADFWGPVERAIAISLFSAATFVGPIFGPIMYVNTMITLVNGVWTRANHDMSSGGFIVDSSLGWRWTAWITMIPASFFGIIAFLTLPETYHPVLLQRRASRLRKETRIWAYHSRLDENTPTFGEILTKYLFRPIQMLFLEPILVCMTIYISLIYGILYLFFVAYPIAFREVRNWKSLGIAALPFLGILVGVLMGCLLVTIATRLWYAPKLQNGSVVPEDRLPPMIVAAILLPIGLFWFGWTSSPSISWAPQAIAGAPIGMGILMIWMQGLNYLIDVYLVVANSAMSANTLIRSAVSAAFPLFATAMYHKLGVDWATSLLGFLSIAMIPIPVIFYFYGAKIRALSRFSPKW", "function": "MFS transporter; part of the gene cluster that mediates the biosynthesis the mycotoxin citrinin, a hepato-nephrotoxic compound to humans due to inhibition of respiration complex III.", "AFDB_id": "AF-Q1ERH8-F1-model_v4" }, { "swissprot_id": "B1B5P4", "sequence": "MGFVLPASFPGASSITTGGSCLRSKQYAKNYYASSYVTTLWHKKGKIQKEYCAVIFSRHNLKQHYKVNEGGSTSKECEKKYVVNAISEQSFEYEPQARDPKNIWGSVNDALDTFYKFCRPYAIFSVVLGATFKSLVAVERLSDLSLAFFIGWLQVVVAVICIHIFDVGLNQLCDIEIDKINKPDLPLASGNLSFRNVVIITASSLILGLGFAWIVGSWPLFWTVFICCMFAAAYNVDLPLLRWKKYPVLTAISFIANVAVTRSLGFFLHMQTCVFKRPTTFPRPLIFCTAIVSIYAIVIALFKDIPDMEGDEKFGIQSLSLRLGPKRVFWICVSLLEMAYGVTILVGATSPILWSKIITVLGHAILASVLWYHAKSTDLTSNVVLQSFYMFIWKLHTAEYCLIPLFR", "function": "Involved in the biosynthesis of sophoraflavanone G (SFG). Can use flavanones (naringenin, liquiritigenin and hesperetin) as substrates, but not flavonols or isoflavones. Shows a strict specificity for dimethylallyl diphosphate.", "AFDB_id": "AF-B1B5P4-F1-model_v4" }, { "swissprot_id": "P96686", "sequence": "MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLADELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLLKDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAIAKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN", "function": "Member of the two-component regulatory system YdfH/YdfI. Regulates the transcription of ydfJ by binding to its promoter region.", "AFDB_id": "AF-P96686-F1-model_v4" }, { "swissprot_id": "Q8VZD4", "sequence": "MDVSKVVSFSRNFAVLVKVEGPDPKGLKMRKHAFHQYHSGNATLSASGILLPRDIFLSGEVAAKVLFEAGQDMALVLTVASVVEPFLTLGHRTSSSISQDPVKLIPGAMIEIMVEGQLKSEKEAPFWVPAQLLSLVDVPVSSAALQSLIEASSGSKDSGWDIGWSLVSAANGSQPSINIEHYSKPLMQLDEPHNANFMAKSATRMAILGVPLSLLGQPSMNFASSSSKGDTLVALGSPFGILSPVNFFNSVSTGSIANSYPSGSLKKSLMIADVRCLPGMEGAPVFAKNGHLIGILIRPLRQKNSGVEIQLVVPWGAITTACSHLLLEEPSVEGKASQWGSEVLSVKSDASIPAQVAIEKAMESVCLITVNDGVWASGIILNEHGLILTNAHLLEPWRYGKGGVYGEGFKPYVLGAEEFSSTGSKFWEQKSQTLPRKAPRNHYSSVGENIREYKHNFLQTGHRDIRVRLCHLDSWTWCPANVVYICKEQLDIALLQLEYVPGKLQPITANFSSPPLGTTAHVVGHGLFGPRCGLSPSICSGVVAKVVHAKRRLNTQSISQEVAEFPAMLETTAAVHPGGSGGAVLNSSGHMIGLVTSNARHGAGTVIPHLNFSIPCAVLAPIFKFAEDMQNTTILQTLDQPSEELSSIWALMPSLSPKTEQSLPNLPKLLKDGNNKQTKGSQFAKFIAETQDMFVKPTKLSRDVIPSKL", "function": "Trypsin-like serine endopeptidase involved in the processing of glyoxysomal higher molecular weight precursor. The dimeric form carries out the specific cleavages needed to remove PTS2-containing presequences, whereas the monomeric form degrades the removed presequences and misfolded proteins (Probable). Not required for degradation of glyoxylate cycle enzymes during seedling development.", "AFDB_id": "AF-Q8VZD4-F1-model_v4" }, { "swissprot_id": "Q8BGT0", "sequence": "MARDAELARSSGWPWRWLPALLLLQLLRWRCALCALPFTSSRHPGFADLLSEQQLLEVQDLTLSLLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAELTACMVRSARPVRLCQTCYPLFQQVAIKMDNISRNIGNTSEGPRCGGSLLTADRMQIVLMVSEFFNSTWQEANCANCLTNNGEDLSNNTEDFLSLFNKTLACFEHNLQGHTYSLLPPKNYSEVCRNCKEAYKNLSLLYSQMQKLNGLENKAEPETHLCIDVEDAMNITRKLWSRTFNCSVTCSDTVSVVAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQENAT", "function": "Required for osteoclast and melanocyte maturation and function.", "AFDB_id": "AF-Q8BGT0-F1-model_v4" }, { "swissprot_id": "Q7UJD7", "sequence": "MADSTGPISLTVHGAAGRMGRRVVALGLADPNFQLVGAIDHAKSDHLGQDSGAVAGEAPSGIEISSHWPVLDDAATNQAVIDFSLPEAIDGCVEHCVKVGSPLVVATTGLSDEQKQNLSEAAASIPVVWAPSMSLAVNLSMKIAEQITAALKDVAGGLDVEILERHHRFKADAPSGTALKFGELIAGQLGESTSHVHGREGHTGARTREEIGYHAIRVGDNPGEHTIVFGMLGEKIELNVAASNRDCYASGALAAAKWLIHQKKGPGLYSMFDVLGMSDN", "function": "Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.", "AFDB_id": "AF-Q7UJD7-F1-model_v4" }, { "swissprot_id": "Q9VVU5", "sequence": "MPVLPMPPLMQNAVEPMQVDIAPPNEDNENNEEQQIVVENPSIDLEVYANQYAGIVRLHRLIYVADVCPVLAVEALKMAITYVQTTYNVNLYQVLHKRLSDLNAGNAPAPPANAGGDQAGAAAPGPLAAAPLPDIAAQPVAQAQGQAQPAVEKDAFAYDAAWVDTKMKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLADHYLSCGDLTNALKCYSRARDYCTSGKHVVNMCLNVIKVSIYLQNWAHVMSYISKAESTPDFAEGSKEANAQVHTRLECAAGLAELQQKKYKVAAKHFLNANFDHCDFPEMISTSNVAVYGGLCALATFDRQELKRLVIASTSFKLFLELEPQLRDIIFKFYESKYASCLTLLDEIRDNLLVDMYIAPHVTTLYTKIRNRALIQYFSPYMSADMHKMAMAFNSSVGDLENEVMQLILDGQIQARIDSHNKILFAKEADQRNSTFERALIMGKQYQRHTRMLVLRAAMLKSHIHVKSISREGGSNHGAELCVSAGSSTTAQLARI", "function": "Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.", "AFDB_id": "AF-Q9VVU5-F1-model_v4" }, { "swissprot_id": "Q12JH7", "sequence": "MDAPSRSHLASPILVANYRSLPSFMYRDSLPEAAVSPQLLALNTRLLETLEQDLAWFNSSDALEQLSGKTYYGSNLPFALAYSGHQFGGWSPVLGDGRAHVLGQLKTAADELIDVQLKGSGATPFSRGGDGRATLGAVIREYLLSEAMAGLNISTTGSLAVIATGEDVWRNGAYPGAILVRTAKSHLRVGSFQYAAVHQGPEAVKTLADFALAQYYPELSHDENPYQALLAQVIKGQAELVAQWMLVGFIHGVMNTDNSSITGETIDYGPCAFMDEFNPNKVFSSIDSQGRYAWGNQGAIAQWNMARLGETLLPLLDSDEAKALEIAQAQLGDFNRLFAEHFYQGMARKLSLDASDPELIPFVDSTLQLMTNTRVDFCQFFNALTEYHSTHREQDAGLVALFSTEAFPSLSSTPAQLLQDWLSQWQAKACDSQAALAAMIKANPKFIARNHKVEAAISAAEQNNDYSLFLDMARVLANPYVLAEQDKHYQDAPTPDQRVKQTFCGT", "function": "Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).", "AFDB_id": "AF-Q12JH7-F1-model_v4" }, { "swissprot_id": "P75826", "sequence": "MFSGLLIILVPLIVGYLIPLRQQAALKVINQLLSWMVYLILFFMGISLAFLDNLASNLLAILHYSAVSITVILLCNIAALMWLERGLPWRNHHQQEKLPSRIAMALESLKLCGVVVIGFAIGLSGLAFLQHATEASEYTLILLLFLVGIQLRNNGMTLKQIVLNRRGMIVAVVVVVSSLIGGLINAFILDLPINTALAMASGFGWYSLSGILLTESFGPVIGSAAFFNDLARELIAIMLIPGLIRRSRSTALGLCGATSMDFTLPVLQRTGGLDMVPAAIVHGFILSLLVPILIAFFSA", "function": "Mediates export of lysine.", "AFDB_id": "AF-P75826-F1-model_v4" }, { "swissprot_id": "A0M684", "sequence": "MLIHTKAIIISALKYGEADLIVKAYTLSDGLCTYMLKGVLKSRKGKFKASMFQSLTQLEIVANHRGGGKMEYLKEAKVTGNYQSLHTHPIKLAMVMFLAEMLRNAIREEESNEPLFHYLEYSFQFLDSTDKIANFHLLFLLNLTRYLGFQPEMGIKDLPVFNLLDGIFQDFSSNDYCIEGKNVDLLKSFLGTDFDALQYIKMNQTSRNDFLSMLLLYYELHIEGFRKPKSLSVLNEIFG", "function": "Involved in DNA repair and RecF pathway recombination.", "AFDB_id": "AF-A0M684-F1-model_v4" }, { "swissprot_id": "Q6F4M7", "sequence": "MHTTDTETFEEQFAIEQRLVDSVVASFDSTTDPRLKELMQSLTRHLHAFIREVRLSEDEWSNAIAFLTAVGNITDDRRQEFILLSDVLGVSMQTIAVSNPAYEDATESTVFGPFFVEDAPEVTLGGDIAGGATGQPCWIEGTVTDTAGNPVPEARIEVWQNDEDGFYDVQYSDGRVSGRAHLFSDAHGRYRFWGMTPVPYPIPSDGPVGKMLAATNRSPMRVAHLHFMVTADGLRTLVTHIFVAGDPQLERGDSVFGVKDSLIKDFVEQPPGTPTPDGRHIGDRNWARCEFDIVLAPEQI", "function": "Involved in the degradation of para-nitrophenol (4-NP). Catalyzes the conversion of hydroxyquinol to malelylacetate.", "AFDB_id": "AF-Q6F4M7-F1-model_v4" }, { "swissprot_id": "Q01389", "sequence": "MPFLRKIAGTAHTHSRSDSNSSVKFGHQPTSSVASTKSSSKSPRATSRKSIYDDIRSQFPNLTPNSTSSQFYESTPVIEQSFNWTTDDHISAGTLENPTSFTNSSYKNDNGPSSLSDSRKSSGGNSVNSLSFDKLILSWDPTDPDEWTMHRVTSWFKFHDFPESWILFFKKHQLFGHRFIKLLAYDNFAVYEKYLPQTKTASYTRFQQLLKKTMTKNVTNSHIRQKSASKLKSSRSSSESIKSKLKNSKSQEDISNSRSTSESALSPTKSGPSKTDEKNFLHSTSTHQKTKSASSLYRRSFISLRGSSSSNASSAKSPSNIKLSIPARPHSIIESNSTLTKSASPPASPSYPSIFRRHHKSSSSESSLLNSLFGSGIGEEAPTKPNPQGHSLSSENLAKGKSKHYETNVSSPLKQSSLPTSDDKGNLWNKFKRKSQIGVPSPNTVAYVTSQETPSLKSNSSTATLTVQTADVNIPSPSSSPPPIPKTANRSLEVISTEDTPKISSTTASFKETYPDCINPDKTVPVPVNNQKYSVKNFLLDQKFYPLKKTGLNDSENKYILVTKDNVSFVPLNLKSVAKLSSFKESALTKLGINHKNVTFHMTDFDCDIGAAIPDDTLEFLKKSLFLNTSGKIYIKDQMKLQQKPKPAPLTSENNVPLKSVKSKSSMRSGTSSLIASTDDVSIVTSSSDITSFDEHASGSGRRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEENAPKMVFKTSPKLELNLPDKGSKLNIPTPITENESKSSFQVLRKDEGTEIDFNHRRESPYTKPELAPKREAPKPPANTSPQRTLSTSKQNKPIRLVRASTKISRSKRSKPLPPQLLSSPIEASSSSPDSLTSSYTPASTHVLIPQPYKGANDVMRRLKTDQDSTSTSPSLKMKQKVNRSNSTVSTSNSIFYSPSPLLKRGNSKRVVSSTSAADIFEENDITFADAPPMFDSDDSDDDSSSSDDIIWSKKKTAPETNNENKKDEKSDNSSTHSDEIFYDSQTQDKMERKMTFRPSPEVVYQNLEKFFPRANLDKPITEGIASPTSPKSLDSLLSPKNVASSRTEPSTPSRPVPPDSSYEFIQDGLNGKNKPLNQAKTPKRTKTIRTIAHEASLARKNSVKLKRQNTKMWGTRMVEVTENHMVSINKAKNSKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNFKSTRLAKFIKSNDKLNSSKLRITSQENKTE", "function": "Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act on this kinase. BCK1 probably phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.", "AFDB_id": "AF-Q01389-F1-model_v4" }, { "swissprot_id": "Q8FDU7", "sequence": "MQCEFKGVISALPTPYDQSQQIDMESLRKLIRFNIEQNIKGLYVGGSTGEAFLQNVAEREKILETVADESDGRLTLIAHVGGISTAESEVLAKAAKKYGYHAISAVTPFYYPFSFEEHCIHYRKIIDSADGLPMVVYNIPALSGVRFSLDQINELVTIPRVCALKQTSGDLFQMEQIKRNHPELVLYNGYDEIFASGLIAGADGGIGSTYNIMGWRYLEIFEAVKNNDVIKAKEMQVACNQVIDTLIQSGVLAGIKTLLYYMGIINTPVCRSPFSPVKEKNLDVLSKLAERLFEEHDRNKKMKII", "function": "Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.", "AFDB_id": "AF-Q8FDU7-F1-model_v4" }, { "swissprot_id": "Q45347", "sequence": "MEFQYRGNKTVLSNCYQNPPLRASRPLYINPANRSEATVYLVETSGGIVEGDHNVFDIDIKEGADVCLIPQSATKIYPSYNGIWSSQDMDITIGPKASLSFKTEAVIPFEQARFNSKTVIQMTSDSTFLWGDILSPGRVARGEVFEYTDVRTNFQVWMDDECLIYDPLLISKDNMGLKKMGMLEDHLFIGSMWFVTPTIEEFDIRELNERLQESPHSKASASMLEGKAVNVRWLASDLVDLKKEMNRIWDEFANYIV", "function": "Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.", "AFDB_id": "AF-Q45347-F1-model_v4" }, { "swissprot_id": "Q99KI3", "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMARDLHFEGMFKKELQTSIF", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.", "AFDB_id": "AF-Q99KI3-F1-model_v4" }, { "swissprot_id": "Q8SU25", "sequence": "MKREVPVSTMSYLVCGMIEYLMEQRSDIEADLKSIGYEVGIKLLELCNFEREVRISTLLYRATFDLLSLVSDSDRRVEKARDVDRTYLLTDSDGLFSRFISVPDEWNGLSADSIVCGMIQAALMASGYDSEVTAFPEPSENLPNRVIFQIRILDL", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi.", "AFDB_id": "AF-Q8SU25-F1-model_v4" }, { "swissprot_id": "A0A067XMN9", "sequence": "MEAADPNNNLTITSPSTLLSNPTQPPAQPLKLRDSCHACASSKVKCHKEKPTCSRCRKRGITCEYFAHRRPGRKQENRAKDTTNHVERQENTTAVEMLDLNWPAPDFSTQTSIANDNLDVFHDIFVPPDQLNNGLTDFTIDFDDFDIQSDPAEIASLPDTSSLESMFVTSPTAPTDTITPNVITPNVGLSVLEGLPDTTHHTQAINLASYIQTPPTEKTPDSRIKHLEENKDPCMTRALSFLTQLSESTSRICKTSETGCSGTNKKSLPESLDGIIAENRRLLEAMSNILQCRCSEDDDLLCIQAIVASKILNLYASAIEIKPSPARVGSGVSTHTTAGQYEPQVEQQLSTRTHPQLASGRDPIRMAAQSVLGELHRVQRLLSQMLQKSKDNETMRRKGSENGLRAVADKVPLTSGVSFGSIEADLRYKLGKLSIEIITLLRGA", "function": "Transcription factor that, with ptaR1 and ptaR3, coregulates the expression of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes.", "AFDB_id": "AF-A0A067XMN9-F1-model_v4" }, { "swissprot_id": "P39902", "sequence": "MKTSRLPIAIQQAVMRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMENVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAVYRCVHCGEQLVAK", "function": "Involved in bolA gene expression at the stationary phase.", "AFDB_id": "AF-P39902-F1-model_v4" }, { "swissprot_id": "Q2A5L0", "sequence": "MQYTLKQISEHLNAKVINEPSGEVIITGLNYAEQAKENDLTLIDKQEHIKLWQNSKAAAAIVSKKISKELAQVNDKPLIVVNNADLAMAKILELFSVPYPEQNGIHEKAVIDPTAKIGKNVSIGPGAYIGKNVEIGDNTIIYANVCIYNDAKVGTNCIIWPSVTIRDRTIIDHFCRLYSNCSIGSDGFGYRPSEDGRTIVRIPHIGNVVIGSFVDIGSNTCINNAKYGSTIIGDYTKIDNLVQIGHNVIIGKGCMICGQAGISGSVTIGDGVIIAGNAGIKDHTNIGSDARIGGKAGVMWDVPAGESHMGYPAYKDSELAKQWIAIRKLPETMKKLKAIAKSLNIDL", "function": "Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.", "AFDB_id": "AF-Q2A5L0-F1-model_v4" }, { "swissprot_id": "Q8SYD0", "sequence": "MLVRNICKFTQVMGRFRVVVNPRDYCHLAPLKRSRYHQRSEFGCRPLCSNAAGYEVSWAAPPASGSSGGMFWAFSAAFTLNLFGGADEKEETPEEKLIKTIKRSILCIQREQYDKAEQMLHLALRMAQDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKMPDDKDILELYGLTKNWFGQLLMKQGKYLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAYVNLEKYAEARETLLEAMELTKELKDATQEGILQANLGLVYLREGLMSQAENACRLAWKLGKQHQNPDAVEQAEYCLNEIKTTLNGEKRQ", "function": "Required for mitochondrial complex III formation.", "AFDB_id": "AF-Q8SYD0-F1-model_v4" }, { "swissprot_id": "Q10267", "sequence": "MAPDISKKRLPCKVLVFNLPPTLPEQVFLQSINSFLPHVEWHRFSKGKATVGTRSELLSFAYLKFQSATAVQEFFRVYQGHTFIDKKNNTYRAIVTIAPYQKIPPSKVKADSLEGSLEQDPKFQEFKVQRESYSQTASNDDVIEKLQTSTPLLQYLAEKKNAVVEKGKSKPSKKSVKAKKKLRLAEKPASNNSKAGKSSQESKKSSKAPAESAAAVIKEDKVSDRKKSKKKPKKTPVSNSTASQASENASDKKTKEKKSSGKQKIASKKKDQLTTDNV", "function": "Involved in nonsense-mediated decay of mRNAs containing premature stop codons.", "AFDB_id": "AF-Q10267-F1-model_v4" }, { "swissprot_id": "P08632", "sequence": "MTRSQKEKMLAGEMYNAADPEIQAELLLTGAWLKRYNDTLGDSAERWNGLLLERLGAVGLGAVIRPPFHCDYGFNIRIGAWVYINYNCVILDVAAVTIGDGTAIGPAVQIYTADHPHDPEQRQAGLQLGRPVSIGRHAWIGGGAIILPGVTIGDHAVIGAGSVVTRDVPAGSTAMGNPARVKAGGRLPKS", "function": "Acetyltransferase implicated in the O-acetylation of Nod factors.", "AFDB_id": "AF-P08632-F1-model_v4" }, { "swissprot_id": "Q10164", "sequence": "MVKMDVVRTTGFFLRSEPTTCRITTFAYSAEIIYFHAETTFLFEKIMKEGNELEKYSKIELNSEIWEDEEEEDNSGIVSQNERLMKLVNKQREIIYELHKDLEKVKKDNTSLRMRLSKYESTDSFPSSQPSRANSPQSDSYSSPYEKGKLFPKISLKSSKDVPTASAHISSSDHEKSSSVSLSALNNYNKTTDIKARSLDRLSDMTRPKLLLNTKRSHRSSEEPGASSPVTSPILKDSQKERIQALRNKAIKTYSVSTESAERIDSIRSDNLSPLSLNTSSFRRPITKPTPFNSDSNISIDPKDNNSNKQDHFAEIEDELRQQFLDIKVGRANASSPRRKSISIVKPHGISSPKHSTNNLSSKSGKFHSDFRVVSENVLLQARSETNSPIIENKEANNFLAPTSNVPAYSTPARPTESPPPPPISSSSTTPRPDDKPSLPPRGLSEDNDSLSLQKTGSSDTRRSSFSTLKIPDSDICFTRRRSDSNRTWTVIDPHHSQSFDNDILAEIPTSKLDNSSQKSPGKLSSKGLLNSFSPISPFSKSKSHNHHPSSQVEKSTSNSKGSMLPLDTLYNNKLSFRLDESLVRYLRFELMKTSLASLSPDFDCIGLQFVVGVSASSHLASQWKDEVWSFTRSIGECRSFATSFVLDIGAPPFPTLDWFTNDSSVIQNELLRRSVDTYFRYIFQTDLKLEQRIKLLEFLSSDTLREYLHDVFFLPPEHAQKEGVLLKYIENSGLVSRYFYLKDNILYFAENRNSPVLGTIHLKDAQVNRYNANLPIFSIIDPPHEFLTGENYQSAFVIQEKQTETRTGTATVHVLLARDVEDQKSWLRAILRQVPGSTSPLNASPFSVLSSDFPGSSRYRDQSSPIRFYGKADSRPVSQEAILSQDISSSPSPVLPPSENVASYADDSLVSNLTMSPKLRDSMEQVPLENHREFEISDRVSELSFDSSTGSVLEIADTRRNQDAPEKHVPVIEIQSSRPSLEKTDQSTPVELLIDSHSQNSQNEEKRSRMKFWAFPHHKAENYEQISDTNIPVIETNVMLSPSSTTSAEPLQKHIVRKSGIFGLPLNEAVNISTQFNDSGLPIVVYRCIEYLESCRAEKEEGIYRLSGSASTIKHLKEQFNEGVDYDLLSSDEEFDVHVIAGLLKLYLRNLPTNLLDTSMHKLFELLPNVPNDSAALGELCDVISKLPPENFALLDSLLHHLRRIIAFEKVNKMNIRNVCIVFSPTLNIPSDIFMMLILNYDHIFTDISRQTNGAQNESDSDVSDDNGEDNEFF", "function": "GTPase-activating protein for Rho-type proteins.", "AFDB_id": "AF-Q10164-F1-model_v4" }, { "swissprot_id": "Q936S7", "sequence": "MEKLRILICDGNTEADRASFKKFVGCAPSKQFESLLKNYNSQIRTEIAFPADPGPLMTLPLGAYDGILITGSNSHIYEAQPGNLRQIEFAQKAFASGTPMFGVCWGMQLAVVAAGGEVLPSRVADCSCETPFATGVELTSYGSGHPMHHSRTSGFDVFSFHSDEVTRLPGGAVVTARNRNFIQAVEIKHGRSTFWGVQYHPELSGWDQAGFLRESARSLVEDGSYETLNHVEHAAQAISMFKAGAQISEENLVHFEGVDTNSFEFRPLEILNWLDHLVIPTAKRKFGWGGGWLQK", "function": "Involved in the degradation of isopropylamine, which is a constituent of the herbicides atrazine. Catalyzes the hydrolysis of gamma-glutamyl-L-alaninol (GALO) to L-alaninol and L-glutamate. It can also uses gamma-glutamyl-isopropylamide, gamma-glutamyl-ethylamide, L-glutamine, and gamma-glutamyl-p-nitroanilide.", "AFDB_id": "AF-Q936S7-F1-model_v4" }, { "swissprot_id": "Q4P3W3", "sequence": "MAKTIDFLASDGEDNFAARTISATSKPNRNDATASSSKPQKRARRSTKGSDDDGNDDFDIASSLLASAAEPAAVGMLSSSQQASQKAYASRVSAKDDDDDDARFIASVMQHANIKAGLEVAKKALSGKNKGKNKLGSGVVTGGGSFQSMGLHPSLLRSLLIRGFTTPTPIQRQAIPAIMSQPPRDVVGMARTGSGKTLAYLIPLINRLNGRHSPTFGIKSLILCPSRELAVQILRVGKEIARGWKADAGEGQDSRGEAIRWAIIVGGESLDEQFGIMSNNPDVVIATPGRMLHLTVEMNLDLKSVEYVVFDEADRLFEMGFAEQLEEMLLRLPPTRQTLLFSATLPKKLVEFTKAGLQANPKLVRLDADSKISADLRMAFFSVKPSEKEAALLVLLRDVIGVPLGEQAARDLDEEAQFNEDASDNQADGQRSRGYGNRRAEFKGKTKDKHLGNKRKRGGPGGALELLPHQTIIFCATKHHVEYLLLLLTTTGYACSHIYSSLDQATRGIQMSRFRRGQNSLLIVTDVAARGIDLPVLEHVVNFDFPPQPRTFVHRVGRTARAGRNGWAWSMCTNAELPYLCDLQLFLARPLVSSHTAIAALANGRDVASADALGLHDSLILGTLPREALDLETEFISSSLTNTSSSTAHDFPALRAVADRAQQKYEKSIAKASQESHRRAKEMVKLGSIEQINIRTASGREGQVPEWTLAGSPLEEMAVHDVVKRPEVYGLNRANKADAVTSALGSDRMDDKVKRGTDNALKEADEAAKRAALLAKVNAFRPQETVFEIGIRGDATPLGALMRSRRQTMQVKTKRAEALEARKRAIEGGGDAMEDDEEVTKPKVAARNKGKKKATAGKADNDEAVVGDAMVDMEQADEADILAAFDTTKPSKAQVQREALTDSETDASESDRDAASARHTKRARTKKAAPTSYRDPNFYLSYEQQGSTSERGYSLNNARSHTDSFIQQASAVSFDLAGDDATLGTQSQRPNVTRWDSKKKNFIQATVGADNKKMIRTESGVRLPASFRSGRYEDWKREKRIDMPKTGEIESNNHRVHERSPPETSVMGLKRFRHTKLSAPKTAGVFGNRRPGQPKRQAAKDEVKSARQIQKDRELKEKRREKNARPSKSDTNRRAKRGAARRGRGGHGPRGASR", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.", "AFDB_id": "AF-Q4P3W3-F1-model_v4" }, { "swissprot_id": "Q9CHQ8", "sequence": "MVIGLTGGIASGKSTVVDFLISEGYQVIDADKVVRQLQEPGGKLYKAIVETYGLDFIADNGQLNREKLGALVFSDSKEREKLSNLQDEIIRTELYDRRDDLLKKMTDKSVSKNFDSKSQGKNLSVNKPIFMDIPLLIEYNYTGFDEIWLVSLPEKIQLERLMARNKFTEEEAKKRISSQMPLSEKQKVADVILDNFGTIEALKKQIQRELARIEEQK", "function": "Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.", "AFDB_id": "AF-Q9CHQ8-F1-model_v4" }, { "swissprot_id": "P41852", "sequence": "MKQKVLIAALFLVAYLGFLLVKLPATLVVRHLPLPPNLVQLEGVSGTLWSGQVARLQYASESLTQLRWELNGWSLLRFAPEVSLRFGDRSGLNGQGVVGWNGAAFGRDITLNVPAPWVLDRVPMRLPFPLTVAGQLQLKVDQFAQGNPWCDNLYGNLHWYGADADTPAGKLPLGDPELKLTCIDSRLVAELKQGSEAVQVLGKLELQPNRQYLFQGTLKPGPELPDQMKQGLPFLGQPDGQGRFPLRYQGRI", "function": "Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.", "AFDB_id": "AF-P41852-F1-model_v4" }, { "swissprot_id": "Q556J9", "sequence": "MNKNKKGFKLFFIFPVIAFGLGTWQVYRYDWKKRLIQRAKDRMEEDPIELSNSFIKNFKGSSFGDLNKYEFRRVYLNGKVIDNQYVLLGPRSIDGTLGYYVISPLQLSDGTRILLNRGWSASTPKSNYKIPYAIEELKLIHQKEKEQGQQQGNQESILYRYFNILGVISKTKERGSAFTPTNQPEKGQWYSLDVDAMADQLNTEPLMINTMDETEINSKPSSLPNPQFKRFDNDVESSFHNKHMSYIGTWYTLSASLFFIYFRYMRKLPK", "function": "Probably involved in the biogenesis of the COX complex.", "AFDB_id": "AF-Q556J9-F1-model_v4" }, { "swissprot_id": "P15030", "sequence": "MTAIKHPVLLWGLPVAALIIIFWLSLFCYSAIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVSWLLVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG", "function": "Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-P15030-F1-model_v4" }, { "swissprot_id": "Q5AM60", "sequence": "MCHKMMNKFQQRLHHTTSTPLFKTCVYFSNWSVYQKKHFPQDIPIEYYTHIFYAFILIDEQTGKLKFSDEWCDLQMPQPSPNQSITGNLQQFYEMKKKNRHLKLIMSIGGWGTCHLFESVVSNDTKFDNFVNSTIEFAEKYGFDGVDIDWEYPKNSTQAAKLVELLARLRNKLNSKYIITVAAPGGSDNIEILKIQEMDKYLTFWNLMCYDFAGEGWSSKTAFHSNLFGNNGDNSLNASDVVQTYINKGVHPTKLILGMPMYGRIFHGVDRPEIGIPFTKERKSGCIEADVVDYNKFGDTFDYEDFDPRKVGALKYDSHSKQLITFDNLQCARIKASFIQSRQLGGGMWWDSAGDVSVTNDGCLVKNFVDQLGGVEVLEKSANNLHGC", "function": "Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in sporulation.", "AFDB_id": "AF-Q5AM60-F1-model_v4" }, { "swissprot_id": "B9KZW1", "sequence": "MGRYIGPVCRLCRREGVKLYLKGERCFGPKCPIVKRHPNKNYPPGQHGPTQRAARRPSEFALQLREKQKLKRVYGILERQFRRHFDEAERRPGLTGDNLLQILESRLDNVVYRLGFADSRRQARQLVRHGHFLVNGRKTDIPSYQVRPGDIIAVRPESRRREYFKVLEETAKNKAVPAWLSRDLETMSGRVLRLPTRDEIDIPPVNTQLVVEYYSRR", "function": "With S5 and S12 plays an important role in translational accuracy.", "AFDB_id": "AF-B9KZW1-F1-model_v4" }, { "swissprot_id": "O13858", "sequence": "MSHASKNYNAQLTAAAASTALHGTKKIYNSNENDRAVNSFLGNRTSYGEAVNGSPQYDYMRSRMSTLGSANQPMAPPSLRNRSSVYLPTPAGPPQIPVNTGKRYTLTSSSANYMTKSERQMRPPKSYDFPPSQQVRPSTSRSPSYASYNSEEVNFQSYQDPRLLPRTSQMYMPDNNYSPAVKSPAAQRRSSSYMVPANSRGSPANYNTPYYPTAIPPPIEEYSPSVSLPTSPVAEESYNNVQRSSTVRNNTTQKSVLKKPSRKMSPAYTSSYRQNSPSSQVPPVSKKHVIIYENKEGSSSSESVYEDVFEDFDPSGSNQASLRSTSTIHYTPSSKRISVIPPNTSNIGSRVVSRSGQNNNQPAQPGQYNQQSQPVQSYQSGQSTQHFQPVQPIQPVQSTQYYQPSSPVQPVQNGVPAPPMQPVQSTQYYQPSSPVQPVQNVKPAQPAQPSLEDAAKRRVEEMLRQMDITPTASSTTANNAYASAEPHPSAFPDDMNSVFSDSSFERERDSGRGRSTNLFSKFKSGRSRSKASGEAPYSYPAPPVPSVNNAGARLTLRDSGAAPEATYSLRQPSNHAYSEGRSYTFTGGQPPSVPTMPYGSRFANDSDSMMGSTADFSSKKKGGKFKAFKKFFKMRF", "function": "Important for the biogenesis of filamentous eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations.", "AFDB_id": "AF-O13858-F1-model_v4" }, { "swissprot_id": "Q28065", "sequence": "MKHQRVPVMILHSKGTMASWPFSRLWSISDPILFQVTLVATLLATVLGSCGIPPYLDFAFPINELNETRFETGTTLRYTCRPGYRISSRKNFLICDGTDNWKYKEFCVKKRCENPGELLNGQVIVKTDYSFGSEIEFSCSEGYVLIGSANSYCQLQDKGVVWSDPLPQCIIAKCEPPPTISNGRHNGGDEDFYTYGSSVTYSCDRDFSMLGKASISCRVENKTIGVWSPSPPSCKKVICVQPVVKDGKITSGFGPIYTYQQSIVYACNKGFRLEGDSLIHCEADNSWNPPPPTCELNGCLGLPHIPHALWERYDHQTQTEQQVYDIGFVLSYKCHFGYKPETDGPTTVTCQSNLEWSPYIECKEVCCPEPNLNNYGSITLHRRPSTSTHCTYISGDKISYECHSKYMFDALCTKHGTWSPRTPECRPDCKSPPVIAHGQHKVVSKFFTFDHQAVYECDKGYILVGAKELSCTSSGWSPAVPQCKALCLKPEIEYGRLSVEKVRYVEPEIITIQCESGYSVVGSENITCSEDRTWYPEVPKCEWEYPEGCEQVVTGRKLLQCLSRPEEVKLALEVYKLSLEIEILQTNKLKKEAFLLREREKNVTCDFNPE", "function": "Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component.", "AFDB_id": "AF-Q28065-F1-model_v4" }, { "swissprot_id": "Q62293", "sequence": "MAWASSFDAFFKNFKRESKIISEYDITLIMTYIEENKLQKAVSVIEKVLRDIESAPLHIAVTGETGAGKSTFINTLRGVGHEEKGAAPTGAIETTMKRTPYPHPKLPNVTIWDLPGIGTTNFTPQNYLTEMKFGEYDFFIIISATRFKENDAQLAKAIAQMGMNFYFVRTKIDSDLDNEQKFKPKSFNKEEVLKNIKDYCSNHLQESLDSEPPVFLVSNVDISKYDFPKLETKLLQDLPAHKRHVFSLSLQSLTEATINYKRDSLKQKVFLEAMKAGALATIPLGGMISDILENLDETFNLYRSYFGLDDASLENIAQDLNMSVDDFKVHLRFPHLFAEHNDESLEDKLFKYIKHISSVTGGPVAAVTYYRMAYYLQNLFLDTAANDAIALLNSKALFEKKVGPYISEPPEYWEA", "function": "Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii. During avirulent type II T. gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol. Not recruited to virulent type I T. gondii PV membrane. May confer an antiviral state for vesicular stomatitis virus.", "AFDB_id": "AF-Q62293-F1-model_v4" }, { "swissprot_id": "Q8MSX1", "sequence": "MSSTKSQVALATNIPTNLSSAASASTAAAAAAVVVVASANAAVASSANSSGVGSGSGPGPGSGAGVSGPVAAGTATAVATGSTVTAATSVAATTSTSVATISTSCSSSSINNINNNCGEECQSAAGSSNLGRQNSFGNRRGNMKGKHLTRSHAMRESTSPPRTPTPRAASEQQQQQLQGEQHEHNNNNNINSSSKAQSAGRGNSPLMETPAVIVTSQQPQQQQQQQQQQQQSVPPKPQQNVPLSNEAEFPKLSPPKKSGGQHNRTNSNGSGMEFNNNNNSSNKKFVVDMKANGLDNKPHNNSSTGVIFNSGMNYKAAERHDRHERHEMSSQNSNLSNNHDEEPYHYEPRGGGGGKKHRANTNAKGNKPRLKNLGGSSSGSIDLGGGGGNGNCNNMSNNGQSNNSSNNTSGFISRENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRMLIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDDARKSILKRDTHSFDEVRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTGGNHDGYSGGGGDEECYGGWEQQQQQQKQSQPPRPKRPNGKMLQMQNSTESRDGMRSGGAVPKSHNFGNYGGPPSSGGPGNNSLPRGDSTNSIKSGRGGFVKQDSTGSTPWRLSPSSSGSIYHYDPSNLPPNQALQHSGNQYQSQNQGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQLQQPQQLHQQSSQQYATTELSCSSTESYAEEEAQSPGMECSEGYESYEQQSLPVQQQLSGNGDSASTKGDDCDSLASATACLSITTSTSTKNYDRIEVQKYKNQATSPNIPACCAVGEKLELEAGLPQEQEQEPMAGPSSSGSATSSVGITELPSSQTPLPMVNQVNCDLQSVSPSTTPYSQCEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQAPDGSTVFHTTTTPNGAAPYCATTYQQGPDGSIYAVPQGMVYAAYPQPGVGTAGGASQPLFQLTTSSHPPAQTIFASPEAGAEIPGGTYMIPVFDPAQQPREGLIPAQAIYQTGPGGPGATTVMPMATAAAYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQLPMAPYPIQYSYPYYHPISYYVPQQAVAAAPMVASQPQVGQAPMQQQAPHTGAGTTTGPPTVVSVSGQQHHQPHQQHHQQQQHSSNGSVVTSSAYGTRVKRTPGGGSIHYNPSYTPSSVAHAGGAHHPSAGSAQIIAAPAASTTTYHALPTLTLAHGGPATGTDLSGAGGAHVYALPAQHALIPTNIFPYAAAAAAAAGGPGGPPTTPQVVQQAPPPPPQSAPHHALITAAPFYPANGGNMDQGASQSAPSTPAAPGRQAPLFSTPPAPNNGSSGSSSAGGGGNSGGYHSNSSTPHYYQGQNSNEGYTSPYEKRNHGGGASGAHSVGVRKPYHPGGYNPRHSVPLGGIPSGAKTPLLNSNNEPTPRASPSSVSLGGASSSGGANSYPHRGPPPHTMGVKRDNKPNQLPLISGPPPSYAANSSPGVSSYESKPPVRLNAGAASFRSQKSMNQDYRRSVSQRNSPSANGGGSGSHESSNNSPNSIVGSQSNSAANTPNAAAPPPPQPQPTLVSHSGGFVVLDQTTGAAMNASPPSLYGGGGGPNAGISGGAGASGAAGSNGGHQPGGGGGARSHIPTAQLHHSAAAAAAAAAGSQQATAAVLSGVAAAAALGGYNPNGASGVYFKYGQTYFAHPSVALPNSRRSPSNDIRPQMAQVAGMYPTMMIQARHPSRHPNPNYKGSRPR", "function": "Required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo. Involved in proper grk mRNA localization and translation in the oocyte. May control germline mitosis by facilitating the cyclin E (CycE) proteolysis by the SCF-ubiquitin-proteasome complex.", "AFDB_id": "AF-Q8MSX1-F1-model_v4" }, { "swissprot_id": "P38037", "sequence": "MEKLTYYQEITFNGKKQKRKKEEVIKMTGKVTKMHSTKNYDVLLENDQEIKAYISGKMSLHNIKLIPGDMVDVEISPFNLTLGRIVFRHK", "function": "One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.", "AFDB_id": "AF-P38037-F1-model_v4" }, { "swissprot_id": "Q9BUL5", "sequence": "MLEAMAEPSPEDPPPTLKPETQPPEKRRRTIEDFNKFCSFVLAYAGYIPPSKEESDWPASGSSSPLRGESAADSDGWDSAPSDLRTIQTFVKKAKSSKRRAAQAGPTQPGPPRSTFSRLQAPDSATLLEKMKLKDSLFDLDGPKVASPLSPTSLTHTSRPPAALTPVPLSQGDLSHPPRKKDRKNRKLGPGAGAGFGVLRRPRPTPGDGEKRSRIKKSKKRKLKKAERGDRLPPPGPPQAPPSDTDSEEEEEEEEEEEEEEMATVVGGEAPVPVLPTPPEAPRPPATVHPEGVPPADSESKEVGSTETSQDGDASSSEGEMRVMDEDIMVESGDDSWDLITCYCRKPFAGRPMIECSLCGTWIHLSCAKIKKTNVPDFFYCQKCKELRPEARRLGGPPKSGEP", "function": "Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.", "AFDB_id": "AF-Q9BUL5-F1-model_v4" }, { "swissprot_id": "A0A120HUS7", "sequence": "MEKSPLKIGILNVMHDKADTKTRLQHVLTHTAIPVDLHFYYPMTHYAGRTVPEAVSSILDPLDIHEVATMDGFIITGSPIETLEFDQVHYIAEVRTLLKTLSQHVPNQLYLCWGGMVALNYFFGISKLILPHKLFGVYPQTILEPHPLLKGLKNDFKSPHARYAEMDVRGIHADPRLTINATTTKGKLFMVTEPTDTQTFVFSHIEYDRWGLDSEYKREVAAHPEIDYVRAKHYYHHKNDYDHPKFNWKKTQRTIFDNWIQHVADHRNDNH", "function": "Catalyzes the formation of O-acetylserine (OAS) from L-serine and acetyl-CoA. To a lesser extent, is also able to use succinyl-CoA and propionyl-CoA as acyl donors, but not butyryl-CoA. Does not acylate D-serine and L-homoserine.", "AFDB_id": "AF-A0A120HUS7-F1-model_v4" }, { "swissprot_id": "Q9Z2E2", "sequence": "MAESWQDCPALGPGWKRRESFRKSGASFGRSDIYYQSPTGEKIRSKVELTRYLGPACDLTLFDFRQGTLCHPIPKTHPLAVPSKKKKKPSKPAKTKKQQVGLQRSEVRIETPQGEYKAPTATALASLSVSASASSSASASASASSHAPVCCENCGIHFSWDGVKRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGDCAACLVKEDCGVCSTCRLQLPSDVASGLYCKCERRRCLRIMEKSRGCGVCRGCQTQEDCGHCCICLRSPRPGLKRQWRCLQRRCFWGKRDSSKRGSKVASQRHSQAPPLPPHPASQYTEPTELHISDIAPTSPAEFIYYCVDEDEDELQPYTNQRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGGNQKRQKCRWRQCLQFAMKRLLPSAGSGSGEGAGLRPYQTHQTHQKRPASARQLQLSSPLKAPWAVVTAPPGPVRDSRKQQAGRGSVLPQPDTDFVFLQEGTSSAMQMPGTAAASTEVPVQAAQCSAPSWVVALPQVKQETADAPEEWTAVTTFLTSSTLQSGFPSKAADPDLSPVKQEPPGPEEDGEEKKDDVSETTPAEEIGGVGTPVITEIFSLGGTRLRDAEAWLPRLHKLLAVNEKEYFTELQLKEEVL", "function": "Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters.", "AFDB_id": "AF-Q9Z2E2-F1-model_v4" }, { "swissprot_id": "P39808", "sequence": "MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILTKEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVLGRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA", "function": "May be involved in the assembly, structure, or function of the flagellum. May polymerize to form a filamentous structure that is part of the flagellum.", "AFDB_id": "AF-P39808-F1-model_v4" }, { "swissprot_id": "A0A0D4BSN8", "sequence": "MKLDDKRILIIGAGEVGTAVAEDLVNRSDPTEIIIHTSRQQTMDMRVGHLKEMAGPRTLLTGSWGDIFAPYELTHRSRSEINDRNVRLALAEFFLQPSGEAQLRRTTIYELISRHRPHIVIDAVNSASVCTYTEDPHQTCGELLDLARGTGGPRTAEAPAELPAVTPDIADVATDALLSLSTPILHRYVDSLRRAMADFQVERFIKVSTTGLGGMGYNCPYTHGSVTEFGLSDALVGKIGSAGVLHQLLWNLHHTAGCDVRLVIPAALIGWESVRHGAYTSRGRPVALQDCSRPLPLHLDRPLGEHAAASSVAEPAAEDEPSAEMVHVPAGDNSTYSRAEMSLSTALGQFESVTREEVAAAVLDTLLGSTRFDLFTAMDTASLQSSYLAAQMRTSTLTSMRQLEKAYDRPSIVSGNLGPTISKDLLELHVLCTAAGSLEQARTMSTTVLASSASALVREDVYLRQQALSIGLAVLLPDDQWLAGPRLSVPSRIDPEAKVTRADIDDWSRQGWVDLRPARILHWQENLRRIEQDASAGKTAFALDDTAYDVGEVLAYHYKLTGQARRIKGL", "function": "Involved in the biosynthesis of the antibiotic indolmycin, an inhibitor of the bacterial tryptophan-tRNA synthetases. Catalyzes the NADH-dependent reduction of beta-methylindolepyruvate to yield indolmycenate.", "AFDB_id": "AF-A0A0D4BSN8-F1-model_v4" }, { "swissprot_id": "D5AQY7", "sequence": "MTDPSVVHARAPAPDRIGRLGAGVRGLMQHAEEAAGLAQRPGLLQGLDPRAKVAGAFALILAAVATRSLLVLLALFVLATALAAASQISPARLARQVWIVVLGFTGMIALPALILVPGTPVLSLPFGLAITEQGLRAAAFLTGRSETTATLALALVLTTPWPQVLKALRCLGVPRAAVMILGMTHRYIFVLADLALDLFEARRSRLVGRLSPAEARRLATGIAGALFERALALSSEVHLAMLARGWRGEVHLIDDFRFRPRDGGALVLAAAILAGVVWAGSVWP", "function": "Part of the energy-coupling factor (ECF) transporter complex NikMNQO involved in nickel import. The complex confers nickel uptake upon expression in E.coli; can also transport cobalt with a very low affinity.", "AFDB_id": "AF-D5AQY7-F1-model_v4" }, { "swissprot_id": "Q20757", "sequence": "MSDSTGRINSKASDSSSISDHQTADLSIFNGSFDGGAFSSSNIPLFNFMGTGNQRFQYSPHPFAKSSDPCRLAALTPSTPKGPLNLTPADFGLADFSVGNESFADFTANNTSFVGNVQSNVRSTRLLPAWAVDNSGNIRDDLTLQDVVSNGSLIDFAMDRTGVKFLERHFPEDHDNEMHFVLFDKLTEQGAVFTSLCRSAAGNFIIQKFVEHATLDEQERLVRKMCDNGLIEMCLDKFACRVVQMSIQKFDVSIAMKLVEKISSLDFLPLCTDQCAIHVLQKVVKLLPISAWSFFVKFLCRDDNLMTVCQDKYGCRLVQQTIDKLSDNPKLHCFNTRLQLLHGLMTSVARNCFRLSSNEFANYVVQYVIKSSGVMEMYRDTIIEKCLLRNILSMSQDKYASHVVEGAFLFAPPLLLSEMMDEIFDGYVKDQETNRDALDILLFHQYGNYVVQQMISICISALLGKEERKMVASEMRLYAKWFDRIKNRVNRHSGRLERFSSGKKIIESLQKLNVPMTMTNEPMPYWAMPTPLMDISAHFMNKLNFQKNSVFDE", "function": "RNA-binding protein that binds to the consensus sequence 5'-CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis.", "AFDB_id": "AF-Q20757-F1-model_v4" }, { "swissprot_id": "A6QLI6", "sequence": "METVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEIGAKPAPRALSTSAVLCQQVTETPPANEKDKAAKAEVQQAPDGSQQAPDGSQQTADGTQLPSGHPSLASSQGTGSKCPFLAAEMSQGGSSVFRKASLALQEDVQEMHAVREEVAQTSVNPSVINVKTEGGELNGLLKNFQDIMRKQRPERVSHLLQDNLPKSVCTFQYDRFFEKKIDEKKNDHSYRVFKTVNRKAQCFPMADDYSDSLISKKQVSVWCSNDYLGMSRHPRVCGAVIDTLKQHGTGAGGTRNISGTSKFHVDLEQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDAGNHASMIQGIRNSGVPKYIFRHNDVSHLRELLQRSDPAVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGLQGGGIGDRDGVMPKMDIISGTLGKAIGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILRSTEGRTLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMSYFVDNLLATWKRVGLELKPHSSAECNFCRRPLHFEMMSEREKSYFSGMSKLVSAQA", "function": "Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.", "AFDB_id": "AF-A6QLI6-F1-model_v4" }, { "swissprot_id": "Q9JIT1", "sequence": "MLRNKDRSSNKGNLAVTAVALQDHLLHDLQLGHLSVADPCKIKARKKEKKSKSLKRDATAIIDTGLRKSTEGPNMEDPEKEYVLDPTPPPLTLAQKLGLLPPPPLPLSSDEWERVKQRSLLQGDSIQPCPICKEEFELHPQVLLSCSHVFHRACLQAFEKFTNKKTCPLCRKNQYQTRVIHDGARLFRVKCATRIQAYWRGYIVRKWYRNLRKIIPPSDAKLRRKFFEEKFTEISHRILCSYNTNIDELFSEIDVCLAVNRSILQQLDERCGQIITKEDWEKIQAQAAHHEIYECSICLTPLSFHGDGRQAAIGTSSQRPRETVLLSCAHLFHNACLLALEEFSLGDNAPFHVCPLCRSCYQKKIVEC", "function": "May play a role in sperm formation.", "AFDB_id": "AF-Q9JIT1-F1-model_v4" }, { "swissprot_id": "O43058", "sequence": "MNFNSTNPYYFTHEKNLNNASKYSELPIAYQEIPLQSLPPYPKVASKLKGVVAGGKENNIASFQKPSSKATRPYIPSYTRLTYSVPPLPIPPPSEQSLDTIIYRNPSVSSSQSQEPEEFFLPLDDGKKPPYSYAMLIGMSIIRSPDRRLTLSAIYDWISNTFSFYNKSNNGWQNSIRHNLSLNKAFMKIERPRNLPGKGHFWSIRPGHEEQFLKLKLRKPGVNSRPAPPVQDVTSSTKYGSSTGSSGFNTFNTSPHIFNQRHQYLQNYYTASLTNIPTISNVNATNFHPLHSQQPYVDTPGIDAPSDLEAKFSDLGVSSVVSVTSPLQSCTNSPSPPLSSPASSASPSESLRNESLGIKSAKSLGLNKDDAPVEGPPVSHLEKDVETPSVHDSVLGFNDTVTNLGKKGLKDGTTNTLQIPAVRLPSLPSSPTIKNPSGLLLKRSNSIDFPTPPKALCPKLFCFRDDIVADDYTKFSLLSPIRSDMSGISASPNTNLKEHRTRILQMLATPDAKQLSSLTSSDAEFWSVTPLKSSILRNGDASKQVTLSESPKGDSLLDGGSLSYFTNNISSVAGLETPSKLPMSKSFDTFEDDFLDPMDMLSFENHFSDFNSNRKVSPVKREVRRKYISSATTIHSSAAQDDTYLPSPTKRKMPLLRQTSTLF", "function": "Required for promoter sequence element PCB-driven, M-phase-specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15.", "AFDB_id": "AF-O43058-F1-model_v4" }, { "swissprot_id": "P19255", "sequence": "MSSSDIFIGETIGTALLILLGGGVCAAVTLKASKARNAGWLAIAFGWGFAVMTAAYISGPLSGAHLNPAVTVGIAIKDGDWSNTPTYFAGQLLGAMIGAVLVWVAYYGQFQAHLTDREIVGGPGAQDTTAKSVEAQEKGAGPVLGVFSTGPEIRHTVQNLATEIIGTFVLLLAILTQGLNDEGNGLGILGALITGFVVVSIGLSLGGPTGYAINPVRDLGPRIVHALLPLPNKGGSDWSYAWIPVVGPLIGGAIAGGVYNVAFA", "function": "Mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism.", "AFDB_id": "AF-P19255-F1-model_v4" }, { "swissprot_id": "P20021", "sequence": "MSEQKVKLMEEEMNVYRVQGFTCANCAGKFEKNVKKIPGVQDAKVNFGASKIDVYGNASVEELEKAGAFENLKVSPEKLANQTIQRVKDDTKAHKEEKTPFYKKHSTLLFATLLIAFGYLSHFVNGEDNLVTSMLFVGSIVIGGYSLFKVGFQNLIRFDFDMKTLMTVAVIGATIIGKWAEASIVVILFAISEALERFSMDRSRQSIRSLMDIAPKEALVRRNGQEIIIHVDDIAVGDIMIVKPGEKIAMDGIIVNGLSAVNQAAITGESVPVSKAVDDEVFAGTLNEEGLIEVKITKYVEDTTITKIIHLVEEAQGERAPAQAFVDKFAKYYTPIIMVIAALVAVVPPLFFGGSWDTWVYQGLAVLVVGCPCALVISTPISIVSAIGNAAKKGVLVKGGVYLEKLGAIKTVAFDKTGTLTKGVPVVTDFEVLNDQVEEKELFSIITALEYRSQHPLASAIMKKAEQDNIPYSNVQVEEFTSITGRGIKGIVNGTTYYIGSPKLFKELNVSDFSLGFENNVKILQNQGKTAMIIGTEKTILGVIAVADEVRETSKNVIQKLHQLGIKQTIMLTGDNQGTANAIGTHVGVSDIQSELMPQDKLDYIKKMQSEYDNVAMIGDGVNDAPALAASTVGIAMGGAGTDTAIETADIALMGDDLSKLPFAVRLSRKTLNIIKANITFAIGIKIIALLLVIPGWLTLWIAILSDMGATILVALNSLRLMRVKDK", "function": "Couples the hydrolysis of ATP with the export of cadmium. Involved in cadmium resistance.", "AFDB_id": "AF-P20021-F1-model_v4" }, { "swissprot_id": "B0R6I4", "sequence": "MSDIDRGLFERVLPARIRGSYAAKFNVLLLVVVIIVAAAGGYIHLQTQSTVGENTERRVSGIAEQQAATLHDWLTQKESTTTFLASNIGGDAVRTSDVKPQLERQLATLQQDVRAIHVVSTSQDTVVASTDDARSGTTLQAGDAPWLSTIEDGTTDVSVSDPYEVDDSPVVAMTAPTDKPGWVLVMTMSLAQHSQSFNSPIATGDVKVVNGDGVITLDNRNRALLEQYTDTAGNVPAAVATARSGQTVYNTEPERTGMDDGRYATAYTPVAGTDWVLTYHVPRGQAYALQSEVTQNLAGLVVVALVGLLLVGLTVGRRTSSALDELAGVAAAIADGDLDTTIPDTDRTDELGQLVGAFGEMQTYLTTAASQADALADQNFDADVLDEDLPGAFGASLSQMHTRLEALITDLDEAREDAEQTRKDAEEARAASERLNERLERRAAEYSDEMAAAAAGDLTRRLDEDVDSEPMQDIAEAFNDMMGDVEATLAQVRSIADAVDAASTDVSTSAAEIRSASDQVSESVQDISADADQQRDRLGTVGDEVTSLSATVEEIAASADDVAETVNQAATESERGQELGEDAVAELERIEATADSAVERVTALEEAVDAIGDVTGVITDIAEQTNMLALNANIEAARADKSGDGFAVVADEVKDLADEVKESATEIETLVDDVQADVADTVADMSELGDRVDAGSETIEAALAALDDIGDQVEAANGSVQSISDATDEQAASTEEVVTMIDEVTDLSDRTATESQQVSAAAEEQAASVSEVAGRADDLDDQVSTLNDLLDQFDARAASADTDEN", "function": "Mediates chemotaxis towards five attractant amino acids (leucine, isoleucine, valine, methionine and cysteine). Probably transduces the signal from the substrate-binding protein BasB to the histidine kinase CheA.", "AFDB_id": "AF-B0R6I4-F1-model_v4" }, { "swissprot_id": "Q5A1L6", "sequence": "MSTRDLPHSFSELSYGWVKRIRAEFTVGKSKEQLLAEDYHSTTDEDSEVVTSVKANSLWPAFASGAGLFSDGYVNNSISTVLFCLKKIYPDEITKSNAINNIASIAFVGTVVGQLGFGYISDRIARKGGMMAANVMLIFFTLMCAVGSWGVTVQGFFACLTVWRFFLGVAIGAEYPTSSVIASEFANQLPPGKRNRYFSWFTNAMIDSGFVVSAFVPFVLIWIFTEKHLRALWRVAIGLGVIPPLSLFFMRLKMKNSSSFQKLHMKNVKYRDYPWWLIVKFYWFRLTIVSLIWFIYDFSAYSFGNFNTIIIGEIIPEAPIWKQWGWSIVFNLFYIPGAFLGAISADYIGPRLTLALGVGIQGVIGIAMSACLNSLKKHIAGFVVVFGIFTTFGEFGPGDNIGLLASKTSATAIRGQYYGIAAAIGKIGAFVGTWVFPAIQSKYANNANPDLQLQVPFYISSALCLFSACLAIFFCPQVGQDAIYKEDHDFVQYLSNNGFDINMLGEGGDVREVCRESDSLEKGKRDDFQVDNNSL", "function": "Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT4. GIT3 acts as the major GroPCho permease. Does not possess detectable glycerophosphoinositol (GroPIns) transport activity. The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism. This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids.", "AFDB_id": "AF-Q5A1L6-F1-model_v4" }, { "swissprot_id": "Q5UYI1", "sequence": "MDAALGPPEQMAELEEDLTPMMAQYYELCRQYDDALVLFQVGDFYEAFCAAAKRVARLCEITLTQREDSTGEYPMAGIPIDNAESYVETLLDAGYRVAIADQVEDPDEVSGVVERAVTRIVTPGTLTESELLGGADNNYVAALTAGERYGLALLDISTGDCYATSVGSESAVADELSRFGPAEAIVGPDVDVDRDAVFGPACLVTRYDADAFAQDRAEDRVGQYFGPPERLLAGGAEIRACGGLLAYAEYTRGSSGAVGPDGEPVDPDVDPAGTLDYLNHLTRYDPREYMLLDAVAVESLELFKRRSVRGHENRTLVDTVDETACALGRRKLTDWLRRPLLDADRIEARHGAVAELQRDPATREELSALLAEVYDLERLISRVSRGRANARDLRSLAATLSVVPDIRDHLADADARLLADLHATLDPLAETREEIEAAIRPDPPQQVTEGGVIREGYDEELDRLRSTEQSGKEWIDELEASERERTGIDSLKVGHTSVHGYYIEVTNANLDAVPEDYQRRQTLKNSERYYTPALKEREDEILRAESAADDLEYDLFCAVRDEVADEAERVQALADRLARLDVLVSFAEVAAQYDYCRPTVGSDGIDVTAGRHPVVERTEDAFIPNDTHLGSGPVPASRDGSDDGVTADDIQPFLAVVTGPNMSGKSTYMRQVALICLLAQSGSFVPAKAADLPILDRVFTRVGASDDIAGGRSTFMIEMTELATILDAATENSLVLLDEVGRGTSTADGLAIARAVTEYLHDEVGAYTLFATHHHDLTAVAAALSGATNRHFETSREDGDVRFDHELAPGPAAASYGVEVASMAGVPDSVVERSRDLLADAETADTGVEATRETEVASEPRPGTRADSETDSTATETTGPTENGAASAPAGEATSDDHAQEVFQTNGAAAEDELPESVAQQLASLDVATMTPIEAMNALADLQDRIE", "function": "This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.", "AFDB_id": "AF-Q5UYI1-F1-model_v4" }, { "swissprot_id": "Q6UEF1", "sequence": "MGSHAPAVAGKPDPKKGPYQATPWNIQLSATDTPGFTHVGNLERRSADRASDLVMNNHSKFHTFHDEIVGFHNHISHHVLTLWALGATPDEMQAAYDFNKPFQLLTYYNDPSVNIKLRDPEFFRQGLGNFELYGDYVRFFQAEVAAKGTQTVLHDYLFKGDTLTEDLLARLFSGFLHPLINLGFALEFQQPFLAAECLASTCMHPPYPAEFLTATEQHVECNGRPRSLPILSIAEGMRLDPVVATAVGPEDGNNRIADALLKRALKELIPHLSYFQVEPTEHDLARKTAEILQASAYICGAAQHPRKVEALDFVMLHSLTAAVFFPTIIKQEWISIETRARLLEWKGRSDLITYAALGCPKLYPDRITGYQPKQAATGWSDVVQRARVYQDDGHACKVIRALMCAENVCQPFEGEEGFPLKKADFLTVAHMTMDSVERMSDPNWVRQTEKVKQMSAQGRGQHSQVSAIMLRWVRWCGTEGAWDDFPDLEELSPSA", "function": "Oxidoreductase; part of the gene cluster that mediates the biosynthesis of aflatoxins, a group of polyketide-derived furanocoumarins, and part of the most toxic and carcinogenic compounds among the known mycotoxins. The four major aflatoxins produced by A.parasiticus are aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits aflA and aflB, as well as the PKS aflC. AflC combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by the fungal fatty acid synthase aflA/aflB. The second step is the conversion of NOR to averantin (AVN) and requires the norsolorinic acid ketoreductase aflD, which catalyzes the dehydration of norsolorinic acid to form (1'S)-averantin. The norsolorinic acid reductases aflE and aflF may also play a role in the conversion of NOR to AVN. The cytochrome P450 monooxygenase aflG then catalyzes the hydroxylation of AVN to 5'hydroxyaverantin (HAVN). The next step is performed by the 5'-hydroxyaverantin dehydrogenase aflH that transforms HAVN to 5'-oxoaverantin (OAVN) which is further converted to averufin (AVF) by aflK that plays a dual role in the pathway, as a 5'-oxoaverantin cyclase that mediates conversion of 5'-oxoaverantin, as well as a versicolorin B synthase in a later step in the pathway. The averufin oxidase aflI catalyzes the conversion of AVF to versiconal hemiacetal acetate (VHA). VHA is then the substrate for the versiconal hemiacetal acetate esterase aflJ to yield versiconal (VAL). Versicolorin B synthase aflK then converts VAL to versicolorin B (VERB) by closing the bisfuran ring of aflatoxin which is required for DNA-binding, thus giving to aflatoxin its activity as a mutagen. Then, the activity of the versicolorin B desaturase aflL leads to versicolorin A (VERA). A branch point starts from VERB since it can also be converted to dihydrodemethylsterigmatocystin (DMDHST), probably also by aflL, VERA being a precursor for aflatoxins B1 and G1, and DMDHST for aflatoxins B2 and G2. Next, the versicolorin reductase aflM and the cytochrome P450 monooxygenase aflN are involved in conversion of VERA to demethylsterigmatocystin (DMST). AflX and aflY seem also involved in this step, through probable aflX-mediated epoxide ring-opening step following versicolorin A oxidation and aflY-mediated Baeyer-Villiger oxidation required for the formation of the xanthone ring. The methyltransferase aflO then leads to the modification of DMST to sterigmatocystin (ST), and of DMDHST to dihydrosterigmatocystin (DHST). Both ST and DHST are then substrates of the O-methyltransferase aflP to yield O-methylsterigmatocystin (OMST) and dihydro-O-methylsterigmatocystin (DHOMST), respectively. Finally OMST is converted to aflatoxins B1 and G1, and DHOMST to aflatoxins B2 and G2, via the action of several enzymes including O-methylsterigmatocystin oxidoreductase aflQ, the cytochrome P450 monooxygenase aflU, but also the NADH-dependent flavin oxidoreductase nadA which is specifically required for the synthesis of AFG1.", "AFDB_id": "AF-Q6UEF1-F1-model_v4" }, { "swissprot_id": "P49334", "sequence": "MVELTEIKDDVVQLDEPQFSRNQAIVEEKASATNNDVVDDEDDSDSDFEDEFDENETLLDRIVALKDIVPPGKRQTISNFFGFTSSFVRNAFTKSGNLAWTLTTTALLLGVPLSLSILAEQQLIEMEKTFDLQSDANNILAQGEKDAAATAN", "function": "Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating.", "AFDB_id": "AF-P49334-F1-model_v4" }, { "swissprot_id": "Q46865", "sequence": "MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQVYLKITVIHDVLIVSFKEK", "function": "Initially reported to act as a cotranscription factor with MqsA. Following further experiments, the MqsR-MqsA complex does not bind DNA and all reported data are actually due to a small fraction of free MqsA alone binding DNA. Addition of MqsR to a preformed MqsA-promoter DNA complex causes dissociation of the MqsA-DNA complex, probably causing derepression of MqsA-repressed transcripts. Does not bind DNA in the presence or absence of MqsA.", "AFDB_id": "AF-Q46865-F1-model_v4" }, { "swissprot_id": "A2CIR7", "sequence": "MEETLKSLSMDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGAAADQAAAPPGALLLDHLSPRSPSGGASASSPRGAGGSAAAAAAATPGAVIPVSSVSYEVFLLLLQFLYSGQVSLVPQKGEPRPGCGERGCWHTHCAAAVDLALDTLAAARSFGVEELALLTQKQLAGMVEKASIEDVMKVLMASRKQDLHQLWTTCSHLVAKSGLPPEVLAKHLPIDVVAKIDELRLKSMSRRSPFLSHHHHHPHAAAAGIEASSAAELDDHHKIRRMRRALDSSDVELVKLMVMGEGLNLDDALALHYAVENCSREVVKALLELGAADVNHPAGPAGKTPLHVAAEMVCPDMVAVLLDHHADPNVRTVDGVTPLDILRTLTSDFLFKGAVPGLAHIEPNKLRLCLELVQSAAMVMSREDAQTAAVNAAPIYGESPGGGGGGGVYNASGTSSSMVNLSLDNRMVYLNLGMDAQFGKMNDGGDGDDGGSRGPSSLFSPHGFP", "function": "Involved in defense response against pathogens.", "AFDB_id": "AF-A2CIR7-F1-model_v4" }, { "swissprot_id": "C9K202", "sequence": "MSQFAREIVRNAIYNTSSPDADSVSLRKATTTILLIGVTYCILVGIYRVTLHPLAKYPGPKLAAVTRLWHSYHLCTGDIVSVLSRAHEAYGPVLRIAPDEVLFISSRAWDDIYGARPGKPEMDKDTPLYKGPTAPHSIVTVDGELHRFYRRLLAKGFSDAALREQEPVIQRNINLLVEKLHKEVAAGKTPEMTAWFNYATFDLIGELAFGETYGCLENSHYHPWVEMILEVMKLRAMTHAVGYYPWIFHILMWFVPKSLREKFVTHRRYTHDKVQRRMDQKIHYKDLTTNLVDPQNGLERYEIDGNCSTLIIAGSETTATALSATLYFLTQNENAKRKVIGEIRTTFNNAGDINSISVNQLKYLSACMNEALRIFPPGPAVFPRRVPQGGDFIDGHWIPGGTQVGIAHYCINRSRRNFVDPDKFIPERWLGDPTYQTDDRHAVQPFSYGPRNCIAHNLARLEMRLVLARLIWEFDWELAPGSERWEEEALVFNVWSTKPLMIKFTPVAR", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the fungal neurotoxin cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca(2+)-ATPase with a unique pentacyclic indole tetramic acid scaffold. The hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) cpaS incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-terminal redox-incompetent reductase domain to make and release the tryptophan tetramic acid, cyclo-acetoacetyl-L-tryptophan (c-AATrp), as the first intermediate in the pathway. CpaS catalyzes a Dieckmann-type cyclization on the N-acetoacetyl-Trp intermediate bound in thioester linkage to the phosphopantetheinyl arm of the T domain to form and release c-AATrp. CpaD then regiospecifically dimethylallylates c-AATrp to form beta-cyclopiazonic acid. CpaD discriminates against free Trp but accepts tryptophan-containing thiohydantoins, diketopiperazines, and linear peptides as substrates for C4-prenylation and also acts as regiospecific O-dimethylallyltransferase (DMAT) on a tyrosine-derived tetramic acid. The beta-cyclopiazonate dehydrogenase cpaO then carries out the dehydrogenation of beta-CPA to yield an unstable enimine product, which is captured by intramolecular cyclization to create the pentacyclic fused scaffold of alpha-cyclopiazonate. Finally, the cytochrome P450 monooxygenase cpaH mediates the conversion of CPA into the less toxic 2-oxocyclopiazonic acid, the end product of the CPA pathway in A.oryza.", "AFDB_id": "AF-C9K202-F1-model_v4" }, { "swissprot_id": "P45594", "sequence": "MASGVTVSDVCKTTYEEIKKDKKHRYVIFYIRDEKQIDVETVADRNAEYDQFLEDIQKCGPGECRYGLFDFEYMHQCQGTSESSKKQKLFLMSWCPDTAKVKKKMLYSSSFDALKKSLVGVQKYIQATDLSEASREAVEEKLRATDRQ", "function": "Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics. Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation. Promotes cell motility during ovary development and oogenesis. During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles. Also required for border cell migration during oogenesis. During border cell migration, required for actin turnover and lamellipodial protrusion. Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium. During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary. During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis. Required for mushroom body neuroblast proliferation and axon growth. Plays a role in the positive regulation of protein secretion. Plays a role in the regulation of nuclear localization of actin. Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling.", "AFDB_id": "AF-P45594-F1-model_v4" }, { "swissprot_id": "Q5B5E0", "sequence": "MWSWFGGAAAQKRKEAPKNAILQLRSHLDMLQKREKHLENQMNEQEAIAKKNVTTNKNAAKAALRRKKVHEKNLEQTQAQIVQLEQQIYSIEAANINHETLAAMKAAGAAMEKIHNGMTVEQVDETILRDKLREQQAINDEIAIAITNPGFGEQVDEEDLEAELEGMEQEAMDERMLHTGTVPVADQLNRLPAPANAERKALPFPPQKRTPTDSLPAAKAKQKAEEEDEEAELEKLRAEMAM", "function": "Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB).", "AFDB_id": "AF-Q5B5E0-F1-model_v4" }, { "swissprot_id": "P25932", "sequence": "MHTVEDMLVEKNYSKCPLKKRPVNYQFEAPQNHSNTPNEPQDLCVKKMEILEENPSEELINVSDCCEDEGVDVDHTDDEHIEEEDEDVDVDVDSDPNQTQAAALAAAAAVAAAAAASVVVPTPTYPKYPWNNFHMSPYTAEFYRTINQQGHQILPLRGDLIAPSSPSDSLGSLSPPPHHYLHGRASSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGYPSLGGYTHTHHHHAPISPAYSENSYYSMRSMTPESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPETMPNASAKKDKNQPPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHTLPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCSKTFSRMSLLTKHSEGGCPGGSAGSSSSSELNYAGYAEP", "function": "Transcription factor that can both stimulate and repress transcription. Binds to the consensus DNA sequence 5'-A/GCAGGTG-3'. Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. The somatic protein is required for maintenance of male germ cells. Acts with other members of the snail protein family to control embryonic central nervous system development.", "AFDB_id": "AF-P25932-F1-model_v4" }, { "swissprot_id": "P50190", "sequence": "MRPLRHAVGSSTVTLETDLTLFPEDLHAPLLGSAGNATVDELALAARFDGLHQLLYTRGGVRPTNAAIEEVGKLLLLRLWLSRDDEASVDGVGLRALFDGAVPDESVVEVTKKAFTQVLTVDRMSLRAVDGSSRPLWPYDEPFRLAEPTVLQSALALVNEILGGGTRVADPLGTAFDAFLSGRYDHSGGLGTYLTPSSVARMMAEVVLDLLSSDALADVRAPIIADPFCGTGRFLVAAFDAAEERHENVDLAGLLDGGLVGADQSTTAIAKSGLNLLLYGAQQPEVYAVADSMTDPGLDRLRGTLAAVLTNPPFGGGKYDDALGIDRTRELFPSVRPNRPMDPRLLDSRCLSNFCDPGESLG", "function": "A gamma subtype methylase that recognizes the double-stranded sequence 5'-GATNNNNATC-3', methylates A-? on both strands, and protects the DNA from cleavage by the MamI endonuclease.", "AFDB_id": "AF-P50190-F1-model_v4" }, { "swissprot_id": "O74952", "sequence": "MFPHRVSHLSKLFSRRFPNWKRKVQTDSWSNVPEHIHSKIGRNLFQKEGHPICSLRQLLEQQFQKFEMNNVQKESPIVSVETNFDSLGFPKTHVSRSKSDTYYMNNKTCLRTHTSAHQPEEFSRLAKEGFKKNGFLITADVYRRDEVDSSHYPIFHQMEGALVWNRNDTAKMKNDLKKVALSPSLKSMVDDETTALETHNDMQDIYSLEETKFVSQHLKDTLTTVIHDLVSLAPSISSGAEQVRYRWTYDSFPFTKPSFQLEIDWKGKWLEILGCGVVQDRLLKGAGLNNYIGWAFGIGLERLAMILYGIPDIRLFWSLDERFSKQFLPNKISTFKPFSKYPACFKDIAFWINNDFNPNDFYEIIRDVCQDMVESVNLIDQYTAKSGKTSLCYRVNYRSMERSLRNEEIDKLQEKLRNRVANSLRVELR", "function": "Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.", "AFDB_id": "AF-O74952-F1-model_v4" }, { "swissprot_id": "P35166", "sequence": "MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPAVRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQTSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAITIPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLSDQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEMESSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGFTEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN", "function": "The anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigX, inhibits SigX activity and stabilizes it.", "AFDB_id": "AF-P35166-F1-model_v4" }, { "swissprot_id": "Q5Z678", "sequence": "MEHGGHELAVVVLVLLLLVSATSCTFLEEDVILGTVEEAKVARLGGGGGGGSKGANASTRRADNTCAGVGVGVGGGGGGGGGGGGGGRGRFYLGWKEEIAGMAGRPETAAWLRAVRRRIHERPELAYEEVETSRLVRDELDAMGVGFRHPVARTGVVANIGTGRPPVVALRADMDALPIQEAVEWEHKSKNPGKMHACGHDAHVAMLLGAAKILKAREHHLRGTVRLLFQPAEESGAGAKRMIEGGALEDVEAIFAVHVSHQHPTSVIGSRTGPLLAGCGFFKAVIHGGRRSGDAVLAAASTIISLQSIVSREADPLDSQVVSVAMVNGSDHPAATARAAAAEEEEEFVLGGTFRAFSNASFYQVRRRIEEVITAQARVHGCEAAVDFFENQSFYPPTVNDARMYAHVKAVAGELLGAGSYRDVPPMMGAEDFSFYSQVVPAGFYYIGVRNETLGSVHTGHSPYFMIDEDVLPTGAAFHAAIAERYLANHSPSSSSSSDSDDPDVELEAS", "function": "Hydrolyzes certain amino acid conjugates of the plant growth regulator indole-3-acetic acid (IAA).", "AFDB_id": "AF-Q5Z678-F1-model_v4" }, { "swissprot_id": "P96855", "sequence": "MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRPVFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAVATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAPGGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLEVSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVKHLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKANAKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAGVRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPAPYGRGASPAEQLLIDQELAAAKVERPDLVIGWWAAPTILEHGTPEQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLREITGDSLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATGTALGNPMEELLKVLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGAQSSVRKLIGVRYRQALAEYLMEVSDGGGLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR", "function": "Involved in the second cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the dehydrogenation of the five-carbon steroid side chain of 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) to yield 3-oxochol-4,22-dien-24-oyl-CoA. Can also use 3beta-hydroxy-chol-5-ene-24-oyl-CoA, and shows weak activity with cholyl-CoA and deoxycholyl-CoA.", "AFDB_id": "AF-P96855-F1-model_v4" }, { "swissprot_id": "Q75EE0", "sequence": "MTHSRTALVLIHPATTTRPELLTAAKQHSSLSGANIEQHLVNKLNDGSLQLQDNSYDVIFYVTPEAADEILFPRRLIGVLAAALRAGGSLHGLYDKYQVDALLSGFDIVREPTYHWQKRAVTASAPVKLAPRQPVSAAGLPRFKRASAPSPAAVTPTLDEVPPAAVDPVKAALLDSAAGDAPIAENDLVVGHDSTPITLLTCGRTQTRRRKACKDCTCGLREENEKEISDTHARQEKLLLGDAVKFSEPELAEIDFTIEGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLSAISDDL", "function": "Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.", "AFDB_id": "AF-Q75EE0-F1-model_v4" }, { "swissprot_id": "Q04733", "sequence": "MTSVRGASKTGRTSKTSTATTALVLACTAHFLVVFDTSVITVALPSVRADLGFAPASLQWVVNSYTLAFAGLLLFGGRLADIHGHRRVFLGGLAVFTLTSLIGGLATSPASLIAARAGQGAGAAVLAPLAVTMLTTSFAEGPRRTRALTISTAVALVGGASGNLLGGVFTEFLSWRSVLLVNVPIGIPVLFLAARVLAGPRKRPWGRVRLDLPGAVLATAGLTLLTLGVSQTHEHGWGEAAVAVPLAGGLLALLAFVVVEARFAASPLIPPRLFGLPGVGWGNLAMLLAGASQVPVWFFLTLSMQHVLGYSAAQAGLGFVPHALVMLVVGLRVVPWLMRHVQARVLIAAGAAIGALGFWWQSLLTPDSAYLGGILGPAVLISIGGGLVGTPLARTVTSGVGPLDAGAASGLMNTTRQFGGAFGLAVLLTVTGSGTSGSPAELASHYGDAFVGIAVFMLAIAVLTPVLPALARSTPPGVIHVSPVAR", "function": "Involved in cephamycin export.", "AFDB_id": "AF-Q04733-F1-model_v4" }, { "swissprot_id": "Q9YG32", "sequence": "MFLSGRDLVLLGVVKGHSNGAIQPAGVDLSVGEIESLADAGFLGEEDKIMPKGDRIQCEYGVCELEPGAYRLRFNEVVSIPPGHVGFCFPRSSLLRMGCYLGCAVWDPGYTGRGQAMLLVANPHGLRLEMGSRIAQLVVARVEGPLTSLYKGDYQGEGL", "function": "This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.", "AFDB_id": "AF-Q9YG32-F1-model_v4" }, { "swissprot_id": "P0C8X8", "sequence": "MNTKVVLIMLMITSVILVVEAETLFTANCLDRKDCKKHCKSKGCKEMKCEQIIKPTWRCLCIMCSK", "function": "Blocks voltage-gated potassium channels.", "AFDB_id": "AF-P0C8X8-F1-model_v4" }, { "swissprot_id": "Q501D5", "sequence": "MGGPAYDCLTNPLGAVRFSFVNALSSGYDPASSVGKDWGVVDLFRHYFSDESAISQVPILDSSSIKWVQPKTLVRFRGMIQDMLGNEFYAGAYKDDSTWRTNKYSDVSQFPEGSSTEIQVWERRLLYCVPVPGKNQWTECSSQELKNRFLDLTGQNREKRVRVDEEMTDSMDSSTLEAGRNGSPFKKMKVGEATSSASESQVPQTSGIPPATSADSLPCLVKIYDSPESDLKLNDVVEFLGVLTFDPIVMMDTDTLDENSDALSEAESVQMPSGKVPRLHCLIHRKLETQHFLHGSSLLPEPKSPQIFKEIRESLMKYLTGLLGNDHIAAQFLLLHLLSKVHGRVDNVAVGKLSLNLIHLNKESMSIFGTQLSGALKSLLPFTQSIPLTIEYLNTASFGPKKDYGINRLMPGVLQIADGTHLILDETELQPGTLNSVGVENANLLKNLLECQKVEYDFQYYKMEMATDVQMLIFSEGKSNIMPADLVLPLQPSQVNSLEVITPETAETWRCYLATCKSLSHSIGQELQQVVENDLVAARQTDRSLGSQDLSRLLTMARMMSVSYGETTLSLEHWQMVLELERLRKERLK", "function": "Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin. Required for sister chromatid cohesion.", "AFDB_id": "AF-Q501D5-F1-model_v4" }, { "swissprot_id": "P32521", "sequence": "MYNPYQQQGMGYQQQQQQQQQQPNGFYPQQQQGQSSNQPQGQPQPQQQMAFNQPQATGIGGMPQSFGNSFSSMPQQPQTGYNNNGNNGSVYGNGNFGQQPQQQQQQAKPQHTGYVPNSSMPMMNTTGTMPPPNPAQQPQLQSIQPQGTGYYQAANTANVHSVQPLQSQGTGYYVSTPNLISSNQTQQPLQAQGTGYYQSQPQQVPPPQQAQSLQPLKPQQTGFYLQPQNQAPLEPLKPTATGFVNSFANNGLNNDIKIPAIRLSFITAQDQAKFETLFRSIVTNGSNTVSGANCRKILMRSGLPPSQLARIWTLCDTSKAGELLFPEFALAMHLINDVLQGDTIPYELDSKTKNEVSSFIDAINLSIANQDSSANDAPKTPFDEFITAGVQNLQPQPTGYMPQTSFGIPLQSQITGGGVASALNPQSTGFMAPTTFNMSMNTGTPGLNPQITGGAPASMQPNITGNALQPQTTGMMPQTTGMMPQTTGMMPQTSFGVNLGPQLTGGALQSQYTGGYGSVMPQQSGPASMPNLSFNQQGLQSQLTGLQPQPTGFLPPSNFSATMPLTAQKTGFGNNEIYTKSNFNNNLIDNSSQDKISTEEKSLFYKIFETFDTQNKGLLDSPTAVEIFRKSGLNRADLEQIWNLCDINNTGQLNKQEFALGMHLVYGKLNGKPIPNVLPSSLIPSSTKLLDNLKNQLKTEPTTTKEKPSFGKIDALSYKNNDDDVLPNYRNRRKVYSAKNEEQSSFSSPSAKSVNHSSSTLQTDDISVDKTVEKKTAKPKYAGFSREINLKNIASLENEIKNISNPENCYDSSIPSDLTSRFDAIIAKLPNLFNEISTIDNEITNAKIQLYRKKNPSSIIGSGPNGEITENDRKKAKSRALLRARMSALTGKSTESEDSLSMEDEQQSAEIKRIQQENGKNQEIIKDIRSSISDISASLKSTMTGSNMISNQEFERWEFGIGLEDGVREFLDDLKSNSNKSVTESSPFVPSSTPTPVDDRSSSPSYSQFKTAEERAAYLKEQAKKRMKEKLAKFDKNRRNVTQSSRSISSENSREQPQQIAGSSNLVEPRATPFQEEKYVEVAQPTQPVQSTQPVQPTQPVQPTQPVQPTQPVQPTQPVQPTQPVQNVYNAKQESDDEDEDDEEKRLQEELKRLKLKKKADKEKRLAALRKQIEDAQNESDEEETNGKDNFGGHVNVPQAAPVAPSAAFSQNSTNAPRSVHAAVTPAAGKNSTGLPSTTMGHNPYFKDASASSTSTFDARAAEMQRRIQRGLDEDEDDGWSDEDESNNRVAVDNKVEEAKIGHPDHARAPPVTAAPLPSVTPVPPAVPVPQANTSNEKSSPIPIAPIPPSVTQEPPVPLAPPLPAVDGFQEPPIPSAPAIATAVQKSGSSTPALAGGVLPPPPPLPTQQASTSEPIIAHVDNYNGAEKGTGAYGSDSDDDVLSIPESVGTDEEEEGAQPVSTAGIPSIPPAGIPPPPPLP", "function": "Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. Required for the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface.", "AFDB_id": "AF-P32521-F1-model_v4" }, { "swissprot_id": "Q9GTD4", "sequence": "MMKDEYNSQECMVCSAPADGLHYGAISCRSCNAFFRRTVVEKAEYRCKHTNTCLIDPDGRCACRSCRFTKCIEAGMKIGAVQPRRDPTGSQKERRKRAGGVGEMMSMNNSPLERNGNSFSSDGPTSNSFIVDAIRTDYGFATPRRISTDYSNSPDRYRKYVKIELDDEPIPSTSSAPEKQSCQSSPNDDEQQEFNHLVYAFGEHQRMMQLSFSTFEQFLDEHSNGPKLRRMDPLDVSKLSAVELTGLLYWIEKQQPYGELPVEDRSSLLKRYSVRKLSLDHFYSASKHPEYCARGEFVMNNFTFVPADRTGFELPDDDPHQIQAKREHCRTFAPTFNRFWKNVIRPFVLMKVNDAEVVFLHIMLLWSVTNNEHVTEDTRKVMKQRRDWAMNRLFDWYNEHGTSDPPLRFGQMILLLGEIELICDMHCQDFQVAKLFEFCDMSKFWYETLCYAPCNTNVLKFDPNLLENLKRFTAISVMENNGGLRPFVKTEIKQDPVLYSSPEVIAPESCYNDYQTVDIPVDCNPHTEPVSMDPNLANIDPAVLVFNAHMLPSVMAPLPDDADYHRPQLYHTQSEEVMT", "function": "Orphan nuclear receptor.", "AFDB_id": "AF-Q9GTD4-F1-model_v4" }, { "swissprot_id": "P50189", "sequence": "MQNAVSQAISQGIHVRREILGSLTYEQRVFLLEDLFVDLFGHQHVMLQRWAALTGQSAQVDTGYIAQFVASIVLGEPGQGFRGKGDDLADGSEVKSAANISGVDRPRWNHNLGSLDDDEHRRSRGLPTAGEEYLGVPYMFYLLVDRPHGVSDPAPIRIRAWCIDAQEDGDWRDLFETFLTSRRGRTYNFQLHPPVGYDDDVVVNTLGNLDFSNVLVFDARLSLADRDRPEIDWHVPLPTQVIPVTGRTRALRYGGRGARPTRLTNTADIVLGTNDLGALFPGVLAPRDSYDLATVSEIETEAEVEEYS", "function": "A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GATNNNNATC-3' and cleaves after N-5.", "AFDB_id": "AF-P50189-F1-model_v4" }, { "swissprot_id": "Q1PDW3", "sequence": "MIIMMNCFPCFTSQKSRNAPCTTNETNDDNVEHDEFRPPVVATTKRTEEREPAEQQPPVKTFNFRELATATKNFRQECLLGEGGFGRVYKGTLQSTGQLVAVKQLDKHGLHGNKEFLAEVLSLAKLEHPNLVKLIGYCADGDQRLLVFEYVSGGSLQDHLYEQKPGQKPMDWITRMKIAFGAAQGLDYLHDKVTPAVIYRDLKASNILLDAEFYPKLCDFGLHNLEPGTGDSLFLSSRVMDTYGYSAPEYTRGDDLTVKSDVYSFGVVLLELITGRRAIDTTKPNDEQNLVAWAQPIFKDPKRYPDMADPLLRKNFSERGLNQAVAITSMCLQEEPTARPLISDVMVALSFLSMSTEDGIPATVPMESFRDKSMSIALSRHGSCSVTPFCISRKDVGNKSSSSSDSEDEEEEKEQKAEKEEESTSKKRQEQEETATDSDDESDSNSEKDQEEEQSQLEKARESSSSSSDSGSERRSIDETNATAQSLKISYSNYSSEEEDNEKLSSKSSCKSNEESTFSRYDSGRDHDDSSRNTSMRINSLAHDDKEEDEEENHETRSYSDHDDSPRNTSMRINSLSHDDDEEEEEENHQTRLEHIHSSKSEDQSVYSDDDAGESGESSLHRIEAKEEEHISSDHD", "function": "Involved in pollen tube guidance into micropyle. Participates in perception of the ovule-secreted peptide signal LURE1.", "AFDB_id": "AF-Q1PDW3-F1-model_v4" }, { "swissprot_id": "E9PZZ1", "sequence": "MPAHVTPRTEDARRGAGPSSACGCSWFCHLRPVEDPASPSVCLAAVATMHGTSRTSATSVNADCCIPAGLRLGPVPGTFKLGKYLSDRREPGPKKKVRMVRGELVDESGGSPLEWIGLIRAARNPQEQTLEAIADLPGGQIFYRALRDVQPGEELTVWYSNSLAQWFDIPTTATPTHDEKGEERYICWYCWRTFRYPNSLKAHLRFHCVLSGGGGRAFLPQEHAARPGASPVAEGLGLPPKPTVPDLTAPVQAIALRPQAPAAQLAQACGARESIKREASLAPLATSPPPGKWGTPKKGKEQPDRAHSQFLGIVGGSSGGGGGLPFYPGVRSAFKPAGLARAAAQSDPYREEGGGKGPGLALGRLLGGGRAGGRPGSGESPAGHHHHHHHAHHHHHHHPKCLLAGEPPPAGLPCPGALRAFPLLAGHPEEASAFKHVERAPPAAATTSLPSARYAALPAPGLPVERCALQPLDGGSLKAYPGGGGGGECSPLPAVMPAFTVYSGDLLYGPPAAYYPLKLHLGGLLKYPESISYLSGPAAAAAAAAAAAAAAAAIGPAELGSLASIDREIAMHTQQLSEMAAGKSRARLDSGTLPPAVVAATGPGGGGGGGSAAGKPKTGHLCLYCGKLYSRKYGLKIHMRTHTGYKPLKCKVCLRPFGDPSNLNKHIRLHAEGNTPYRCEFCGKVLVRRRDLERHVKSRHPGQSLMAKAGDGPGPEPSYALEPGDPKSEDSDVDVCFTDDQSDPEAGGRGEHDS", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-E9PZZ1-F1-model_v4" }, { "swissprot_id": "Q6CMF1", "sequence": "MVEEGANKTVGAPTVGDDQQPKEFVRPPFTPFQDILDAFNYLMWNPEANAIAMPVLILLESIAMKFIQNKVSYTEIDYTAYMEQIWMIQNGERDYSQIKGGTGPLVYPAGHVFIYKIFEWVSDGLENISEAQDLFRYLYVITLMIQFMCFGLLNIPPGYAIFAILSKRLHSVYVLRLFNDCFTTLFMSLAVLVMILCAKYKIRGFLVLIGSSFYSMAVSIKMNALLYLPGVLLTIYLLERCNTFKIVLNLAVMVIWQVIIAIPFWKEYPWEYLQSAFNFSRQFMYKWSVNWQMVDEEVFLDPLFHRSLLISHVIVLVVFLFYKLIPTNMNTPAGLLKIGKANLLHPFTDAVFSAMRVNAEQIAYILLVTNYIGVLFARSLHYQFLSWYHWTLPVLLNWANVPYPLCVLWYLTHEWCWNSYPPNATASTLLHACNTSLLLAVFLRGPANSKSGDNETTHEKAE", "function": "Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.", "AFDB_id": "AF-Q6CMF1-F1-model_v4" }, { "swissprot_id": "P0CN27", "sequence": "MPSRGSFRGRGRGSGSGFGSNTRFTGRRRGRGGGGGGGGVAYGIDRRPATSTNQANREDGTAATEKFEEVKVYDEIDEKIGFWRFESVRAEGEEKVGWLVNMHQTLVPSDVHPGGLAAVDYYFIQDDGGSFKVSIPYEPYFYLTCRGGTESIVEEWLLKRYEGIIIRIEREKKWDLSLPNHLLSAPPVFLKLFFHNTADLQTIRRDLLPLARSNSEKFTAVDAYADVVSAEAAANGHGDDENRAWGAEDDTKKKKDKEPSECIIEVREHDLAYHLRVAIDLNIRVGLWYTVTSRTGVITLERIPDRVKRADPVVMAYDIETTKQPLKFPDQQTDQIMMISYMIDGMGYLITNREIVGEDIDDFEYTPKDEYPGEFTVFNEPDEPAVIRRWFEHIRDSKPTVIATYNGDSFDFPFVDARAKIHGISMYEEIGFKPDIEEEYKSRSTMHMDCFRWVKRDSYLPQGSQGLKAVTTAKLGYNPIELDPELMTPYAIEQPQILAQYSVSDAVATYYLYMKYVHPFIFSLCNIIPLSPDEVLRKGTGTLCETLLMVEAYDAHIIMPNRHEDPHGVTYEGHLLASETYVGGHVEALEAGVFRSDIPTHFKIVPSAIQELIDDLDAALRFSLIEEGQVKLEDVENYDEVKQQIQTALETMRDEPNRFDNPLIYHLDVAAMYPNIMLSNRLQPDSVKEEADCAVCDYNRPDKKCDRRMEWAWRGEYFPAKRDEVNMVRYALEQETFPPKRPYDPKRRFVDLTPTEQSALLHKRLGDYSRKVYKKTHDTKIVTKTTIICQRENSFYIDTVRAFRDRRYEYKGLHKTWKKNLDKAFEEGGAVATVDEAKKMIVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGITCLTGATIIQMARQLVEQIGRPLELDTDGIWCMLPGVFPEDFNFKLKNGKKFGISYPCTMLNHLVHAQFTNDQYHELVNNDSGTYNVKKENSIFFELDGPYKAMILPSSKEEDKLLKKRYAVFNPDGSLAELKGFEVKRRGELQMIKIFQSQIFDKFLLGKTTEECYAAVATVADQWLDILQSKASSLHDDELVDLIAENRSMSKTLAEYAGQKSTSISTARRLAEFLGEQMVKDKGLSCRFIISAKPNGAPVTERAVPVAIFTAEEPVKRHYLRKWLKDNSLTDFDLRTILDWDYYTERLGSVIQKLITIPAALQKVPNPVPRIRHPDWLYKRIATKEDKFQQHKITDMFTKLKDMEDLGDGQKKVGPKLAVVRRRNRKEQEKESEVEEVPPEPEYDYAGYIRIMKKKWRKQRQEKARARKSGLRQDGTISSMLRTQTSSMNSKQWDVIQIASTNRPGEFKLWLAIDGTFQSVRLKVPREFYLNFKEDPEPQMLATDRYEAVEVVRTLPRGQPARHLYKLSVDEVLFMEGESHFSTLINNPNVDGAFELQVPLVVRALLSLGTSCALRSNILGGLNRGLDKGFDLVDLERSGNLSRRKYLNEGRGIRYHFLFHAVADQRHIIGLFSPDSTNASIYLVDRAKNRQQLPNPLKFYTDRVERAERGVFSYPDMLDFTTSYHSSESSAFKALGKDLQAINHGLNVIALCSPFEHSYYQAKAPVYSNFPFITYRLGKEEDPGLMWLLQTSRRMIGLYLRLSSWLKEQIQIASHFDVPIGNLGADIAVFLADIEFARRLKQQDMLIWWSSTPRPDLGGSEEDANSSEDLVSPHISNRGCYSSTVLEMEVSDLAINAVLQSALVNEMEGSGTGSLAFDSASHNLDEYAKGAVNTSVMLGDAVLSTQTFGVLKSMLRAWYADKARAHVKGDSLSPAEIVVDQFWRWISSSTSSMFEPALHRFLHGLMRKTFLQLLAEFKRLGTQVVYADFGRVFLLTSKPDAGSAFAFAKYLVAAANSQELFRHLIIDVAQFWNYLAWMDVANFGGVKVSPETAASREPPAKRFEISMDWNIQSFLPGTLQPVFERNVASFIFSLYSAKRSSSDGREPLRVIHSLNIDQPGTEATSTMNPTKEKEKKAASKSISQTLTRRLLSDIAAVKRQQAAVHLEPEEAYTLAFPDLPGARSKRINPTLELIKAITEVYSLASEHSIEVQILKRNLLDLIGVKEFSSDAAFNPPCESIEVPMVICKKCNAIRDVDLCRDPDRLPSVNPDSGEMLEPARKNWVCHKCDSEYDRFQIEQPLIEMVTKTITNYQIQDVICLKCSQTKSDNLAATCKCGGGFRTTSNRNELKTKLKMIKSVCDYHKLPFAGSYVEETLSRW", "function": "DNA polymerase II participates in chromosomal DNA replication.", "AFDB_id": "AF-P0CN27-F1-model_v4" }, { "swissprot_id": "Q6P326", "sequence": "MNVSWALLAVVLVLTVATYECRPRGRILGGQDSKAEVRPYMASIQQNGIHQCGGVLIADKWVLSAAHCATNSSNSSLNVMLGAISLSKPEKYKIVVKVLREIPHPLYNSTIKHHDLLLLELSEKVTLSPAVNPLPFQNENIDISAGKRCLVAGWGQMRLTGKKPDTLQELWVPLISRDVCNRRNYYDNEITANMICAGESRKDSCEGDSGGPLVCDGIAVAIVQGGFRKCGNPTKPGIYTLIEPYKSWIMESMYNATLQSNPSPL", "function": "Probable serine protease.", "AFDB_id": "AF-Q6P326-F1-model_v4" }, { "swissprot_id": "P29110", "sequence": "MTDTARTHHDITSRDQYPRDRDQYSMIGRDRDQYSMMGRDRDQYNMYGRDYSKSRQIAKAVTAVTAGGSLLVLSSLTLVGTVIALTVATPLLVIFSPILVPALITVAMLITGFLSSGGFGIAAITVFSWIYKYATGEHPQGSDKLDSARMKLGSKAQDLKDRAQYYGQQHTGGYGQQHTGGEHDRDRTRGTQHTT", "function": "May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.", "AFDB_id": "AF-P29110-F1-model_v4" }, { "swissprot_id": "Q6EWX0", "sequence": "MPPKEESSKVTRRSTRSSASVTVENSEPIESHTPTIDDLTFGEESITIDAVLSNFPGRRSQIFDFIRLMGPLDCPTLPIMIYGGASTGKTSVVLQVLRHLNRPFVYSSCRTCYNPRILFESILNQSLLHRKCSLNGYSSAKRCDKPSDFVNLLREALSSVIKTLESTSETSRSDKPDEKPMGKMVYLILDNVDLIRDWDKGTIILQFLFSLYTVLKMPQLGIILISGLPPDVYYSNMGYTDPIPLYFPEYSEEDLRQIFLRNQPNRKLYSAFLDVVLKPFCRVTRRVEELSTTFSLLFRKFCEPLDDLGISPNEDMKRRLYSHLKPLIAHCLNEIFRVSSHPHDGETRGERRQKASYSSENREELEILDFHMSTSAKFLLLSAFLASRNPATLDASMFDSTGGMDNRKRKRKASEKSMEKKEIAEQEAVMKGPGSFPLERLLAIFQCIASVGDSSFGEEDEEEENTTGYDKENNNLMSDILLQVSSLCDANFLIKSGSCPLEGSIRYRSMVSEDLAQKVAKSLSFPLSKYLYRR", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.", "AFDB_id": "AF-Q6EWX0-F1-model_v4" }, { "swissprot_id": "Q9WVB3", "sequence": "MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVHLENIFSLAENFFQAIERFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTENSAKEEDKQVPESAALQHPKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQEHGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFLIKSPSALLDYYQEDVSRPQPETQESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLERFTVPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQALANTKENMALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDDNIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQVLTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLIITGSRDCASVYHIKY", "function": "As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning. Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4. Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation. Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression.", "AFDB_id": "AF-Q9WVB3-F1-model_v4" }, { "swissprot_id": "P45671", "sequence": "MSAATILVADDDRAIRTVLTQALARLGHEVRTTGNASTLWRWVADGQGDLIITDVVMPDENGLDLIPRIKKIRPDLRIIVMSAQNTLITAVKAAERGAFEYLPKPFDLKELVSVVERALNSNTPPAALPADAGEADEQLPLIGRSPAMQEIYRVLARLMGTDLTVTITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRELIESELFGHEKGAFTGATNRSTGRFEQAQGGTLFLDEIGDMPLEAQTRLLRVLQEGEYTTVGGRTPIKTDVRIVAATHRDLRTLIRQGLFREDLFYRLCVVPIRLPPLRERTEDVPLLVRHFLNQCSAQGLPVKSIDQPAMDRLKRYRWPGNVRELENLVRRLAALYSQEVIGLDVVEAELADTTPAAQPVEEPQGEGLSAAVERHLKDYFAAHKDGMPSNGLYDRVLREVERPLISLSLSATRGNQIKAAQLLGLNRNTLRKKIRDLDIQVVRGLK", "function": "Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.", "AFDB_id": "AF-P45671-F1-model_v4" }, { "swissprot_id": "Q9YDW8", "sequence": "MLKAIVTNDDGVHSRSLRALAESLASRGWDVVVAAPLGNWSGYSKSIGRFRGNRVYRFESRGVRFFTGDMPPAALVGTAIDIAGFEPDIVVSGINYGPNLGIYDFFSSGTIGGALEAALRGFKSVSISSACREEETDCLPEALSISLAVVETSVETLSSSAGLMVVNIPRSPRGFKVTRPCRRVPRFSGEIGEEGSLLVEKFDHSRLFSSEHDSCDGRLFSMGYIPVSLYKIDNGWIHPLDPSRDGYLKAVEDILNYKIFPSAGKQF", "function": "Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.", "AFDB_id": "AF-Q9YDW8-F1-model_v4" }, { "swissprot_id": "O67911", "sequence": "MENIEIVSSGKHTLHGLNFYLSYFDDVAKVLPREHYCFIVGGWVRDRILGEPVGYNIDVDFLTTADPVELAKNFAKRIGGHFFVFEKRGFLIKRPTIASVVLHLPPYRYRFDFSPLKGKDLEKALIEDLKERDFTANAIAVNLDDVLSIGAKQTIVYDPTGGIKDLEQGLLRPVSIENLKRDPVRVLRGFRIAIEKNLQLTEDFYEFVKEDPRIVLKSAVERITHELFKIMKEKTAHKVIRELYEYGVLEAIIPEIGRLREVKDQGEHHIYPLDEHTLKTLEYLEQVIEDRAKYLSAELLENFGKKRVLGEFTDVELLKWGALFHDIGKPQTFAVREGKVTFYEHDKVGAQIVREIGERLRWGDEATEFVAKLVRHHLRPFFLREAFKKGELKRRGMANFWRECGDIAPHLFLLSIADAMASGDEEEDIKALMETIAELESFNRNEMKEEIQKPLLNGDEIMEILGIKPGKIVGILKKALLEAQIDGKVETKEEAIEFIKRSTKNLKPLDEG", "function": "tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the two cytidine residues to tRNA.", "AFDB_id": "AF-O67911-F1-model_v4" }, { "swissprot_id": "A2ZIW7", "sequence": "MASAGDRRGGGGPPGSGDDSGGGWETVEKRVKKPAQQVGKGQWGQWNSPNAAPAPTAPWSGSGAFHHSGNTLVRHSDRRPARGTPRPPPQNRSTGAELQAPRGVVTAPLANGWQWGARSCPPGTESKEGGLPLSGCDPETDNAEGDDTSDDDNDDDMSDDLSDDYDSDASEKSFETRKNHKLFKGFFEVLDALSVEQLNEPTRQWHCPACKNGPGAIDWYKGLQPLMTHAKTKGSIKVKRHRELASLLEEELSRRGTSVVPSGEQFRKWKGLREGTDREIVWPPMVVVMNTVLEQDEDDKWKGMGNQELIDYFSEYAASKARHAYGPNGHRGMSVLIFDSSAVGYMEAERLHDHFVRQRTDRNTWNSAHKVTFLPGGKRQLYGFLATKDDMETFNRHCHGKSRLKYEMRSYNEMVVTQMKQMSEDNQQLNYLKNKMVKKEQHSKLVEDTLSVVTQKLRETMEENTIVRNKAKEKHLEYEKEMKYQEEFFHDQIEKIHKPTEEKEIKFEKLLQEERAKARQSDVDSGSTEDRRQRKEKIQNFIDCQVKDVEEFEAERDKLIKLHEEKKVKLKKEYLAKEFELEKELDTALTALMDKHKPDIFKSSTSPST", "function": "Required for post-transcriptional gene silencing and natural virus resistance.", "AFDB_id": "AF-A2ZIW7-F1-model_v4" }, { "swissprot_id": "G5EGD2", "sequence": "MEDNRKRNMERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLENNLDNEITNEVWTEDTIAECLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLTGRALRDFLHPSDYDEFDKQSKMLHKPRGEDTDTTGINMVLRMKTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFMQGITIPAGQGTTNANASAMTKYTESPMGAFTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKSMKELFAKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSMPAGMQVDIKKEVDDTRDYIGRQPEIVECVDFTPLIEPEDPFDTVIEPVVGGEEPVKQADMGARKNSYDDVLQWLFRDQPSSPPPARYRSADRFRTTEPSNFGSALASPDFMDSSSRTSRPKTSYGRRAQSQGSRTTGSSSTSASATLPHSANYSPLAEGISQCGLNSPPSIKSGQVVYGDARSMGRSCDPSDSSRRFSALSPSDTLNVSSTRGINPVIGSNDVFSTMPFADSIAIAERIDSSPTLTSGEPILCDDLQWEEPDLSCLAPFVDTYDMMQMDEGLPPELQALYDLPDFTPAVPQAPAARPVHIDRSPPAKRMHQSGPSDLDFMYTQHYQPFQQDETYWQGQQQQNEQQPSSYSPFPMLS", "function": "A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection. Required for aha-1 nuclear localization. Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression. Role in life span extension is dependent of temperature. Not required for survival in anoxic conditions. Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3. May be involved in manganese homeostasis by repressing divalent metal transporter smf-3.", "AFDB_id": "AF-G5EGD2-F1-model_v4" }, { "swissprot_id": "Q5NN67", "sequence": "MFDVAPSELLLVAVVALVVIGPKDLPRAMRVVGRWLGKARKLSRHFRSGIDEMIRQSEMEDMEKRWAEENAKLLAENQGQGNQTASTSSPATPSPVSDDPAEQNIVFTSPADLEVNTADTSHLAANHTETTATTAASTPAKPKEADQQEKQS", "function": "Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.", "AFDB_id": "AF-Q5NN67-F1-model_v4" }, { "swissprot_id": "Q6FQ15", "sequence": "MRLVSRRRLKGLALVAFALIGITIFVRILMEFQLEREVSFYKKFFRLKKDGLHGVYNPIDIKQIPKQTIDDLYRAKMETVSASKPIDWSKYAYVNYVTEPNYLCNTLIMFHALIKKFGTKAKLELLISNELFKSEIQSRNEQVQRILKKIRELDSEQIVIKEVQNIVKPTDQSPWNESLTKLLVFGLTEYERIIYLDNDAILQDKMDELFFLPNDITFAAPLTYWFMSEKDLEKTYKEVQHDKMSINLNKYTKQLSNRIRNGKEIYNHLPALPQSLYLNSDRVAKEILDSTSSASPLFDADSLKKVGKVKFASNLMVIKPSQETYDYIINDCLPRIVNKKEKYDMDLINEELYNLRHVVSRQVTLFRKLRSAFKPSILVLPFGTYGILTGSIRKPQEHMIMRNDILGYKNIDDEGNEIQKSIEEVVLNNKYIHFSDFPLGKPWAYSSFDQLKCRVDPASSKDVAADQKNCDVWNSIYESYFTQRMVCSKDDSPKASEIQAA", "function": "N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.", "AFDB_id": "AF-Q6FQ15-F1-model_v4" }, { "swissprot_id": "Q6YR48", "sequence": "MNYKPRTKVIAGNWKMYKCKDEALEFIQKVSLQVPDQTQVQTLIFPQLTLLDSLAQLQGTNLQVGAQNMFYESEGAFTGEVSPQNLLSLGVKHVLLGHSERRTFFGETDQTVNLKLLSALKHKLVPTVCVGESLLTKENNQTQVFLDQQLTNIFAGVPEEALQNIIIAYEPVWAIGTGKSATPQDANKVIEQIRDKVTALYSSQASCAMRIIYGGSVSVANIKTILEQPAIDGILAGKASLQTEDFLFFAQIASKQALASTKDIFQKNDCPFCC", "function": "Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).", "AFDB_id": "AF-Q6YR48-F1-model_v4" }, { "swissprot_id": "P13794", "sequence": "MKLKNTLGVVIGSLVAASAMNAFAQGQNSVEIEAFGKRYFTDSVRNMKNADLYGGSIGYFLTDDVELALSYGEYHDVRGTYETGNKKVHGNLTSLDAIYHFGTPGVGLRPYVSAGLAHQNITNINSDSQGRQQMTMANIGAGLKYYFTENFFAKASLDGQYGLEKRDNGHQGEWMAGLGVGFNFGGSKAAPAPEPVADVCSDSDNDGVCDNVDKCPDTPANVTVDANGCPAVAEVVRVQLDVKFDFDKSKVKENSYADIKNLADFMKQYPSTSTTVEGHTDSVGTDAYNQKLSERRANAVRDVLVNEYGVEGGRVNAVGYGESRPVADNATAEGRAINRRVEAEVEAEAK", "function": "Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium.", "AFDB_id": "AF-P13794-F1-model_v4" }, { "swissprot_id": "P47482", "sequence": "MKQKIIIFGGSFDPIHNAHLYIAKHAIKKIKAQKLFFVPTYNGIFKNNFHASNKDRIAMLKLAIKSVNNALVSNFDIKTKNAFSINTVNHFKSCYPTSEIYFLIGSDKLNELEKWDHIQQLKDLCTFVCYERKPYPFNKKIANQFNVKYLAKCPLEIASSKLLNQPRKKLIPLAVLNYINTNHLYLIPTLKAMVDDKRFQHCLRVGKLAKQLAIANKLDAKRAFVAGAYHDLAKQLPVDQLVNIATSELKITNYPSWKVLHSYVGAYILKNWFGVKDKMIINAIKNHTIPPKQVSKLDMIVYLADKLEPNRKQEQWSGGIEIDQLVKLAKSNLKQAYLITLKYVQNLVKD", "function": "Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield ADP.", "AFDB_id": "AF-P47482-F1-model_v4" }, { "swissprot_id": "Q13790", "sequence": "MTGLCGYSAPDMRGLRLIMIPVELLLCYLLLHPVDATSYGKQTNVLMHFPLSLESQTPSSDPLSCQFLHPKSLPGFSHMAPLPKFLVSLALRNALEEAGCQADVWALQLQLYRQGGVNATQVLIQHLRGLQKGRSTERNVSVEALASALQLLAREQQSTGRVGRSLPTEDCENEKEQAVHNVVQLLPGVGTFYNLGTALYYATQNCLGKARERGRDGAIDLGYDLLMTMAGMSGGPMGLAISAALKPALRSGVQQLIQYYQDQKDANISQPETTKEGLRAISDVSDLEETTTLASFISEVVSSAPYWGWAIIKSYDLDPGAGSLEI", "function": "Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.", "AFDB_id": "AF-Q13790-F1-model_v4" }, { "swissprot_id": "Q5S2C3", "sequence": "MAVPVEEAIAALSTFSLEDEQPEVQGPAVMVSAERAATDSPIEYSDVAAYRLSLSEDTKALNQLNTLIQEGKEMASILYTYRSCVKALPQLPESMKHSQADLYLETYQVLDLEMSRLREIQRWQSSASAKLAADMQRFSRPERRINGPTVTHLWSMLKLLDVLVQLDHLKNAKASIPNDFSWYKRTFTQVSAQWQDTDTMREELDDLQIFLSTRWAILLNLHVEMFRVNNVEDILQVLIVFIVESLELDFALLFPERYILLRVLPVLVVLATPSEKDTEALYKRVKLNRLINIFKNDPVIPAFPDLHLSPAAILKELSVYFQKFSSQTRLLTLPAPHELPPREALEYQRHYLIVNHIGALRAEHDDFTIRFASSMNQLLLLKSNDGAYTEWCREVKGNMYDMVVEGFQLLSRWTARIWEQCAWKFSRPCRDAGETPEASGSYSDYEKVVRFNYTAEERKALVELVGYIKSVGSMLQRCDTLVADALWETIHAEVQDFVQNTLATMLRTTFRKKKDLSRILSDMRTLSADWMANTRPEHEMPSSQHGNDESRGNFFYPRPVAPTAAQVHCLQFLIYEVVSGGNLRRPGGFFGNNGSEIPVNDLKQLETFFYKLSFFLHILDYSASIGILTDLGFLWFREFYLESSRVIQFPIECSLPWMLIDYILEAQNSGLLESVLLPFDIYNDSAQQALVVLRQRFLYDEIEAEVDHGFDIFVSRLSESIFTYYKSWSASELLDPSFLFALDNGEKFSIQPVRFTALFKMTKVKILGRTINLRSLIAQRMNRIFRENLEFLFDRFESQDLCAVVELEKLIDILKHSHELLSQDLSIDPFSLMLNEMQENISLVSFSSRLATQIWSEMQSDFLPNFILCNTTQRFVRSSKVPPTQKPSVPSAKPSFYCGTQDLNAAHQSFARLHSGFFGIPHLFSIVKLLGSRSLPWLIRALLDHISNKITTLEPMISGLQEALPKSIGLLSFDGGVTGCMKLIREQLNWGTKSELKSEVLRGIKEIGSVIYTMGLLDIVLREVDTKRFMQTAPWLGLIPGAEGQIVNAQDGESPLVNLLKSATSAVVSSPGCLNPAAFYTMSKQAEAADLLYKANMNGGSVLEYTLAFTSASLDKYCSKWSAPPKTGFVDITTSKDFYRIYGGLQIGYLEEITAPQSAQHEVLGDSIAWGGCTIIYLLGQQLHFELFDFSYQVLNVSEVETVSASHTHRNPQIHQGWEGLLEGMKKARRLNNHVFSMLKARCPLEDKTACAIKQSGAPLPRVRFENTVSAFETLPQKGTVG", "function": "Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the ARP2/3 complex. Interacts with the active form of RHO-family GTPases.", "AFDB_id": "AF-Q5S2C3-F1-model_v4" }, { "swissprot_id": "Q7M4L6", "sequence": "MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL", "function": "Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.", "AFDB_id": "AF-Q7M4L6-F1-model_v4" }, { "swissprot_id": "Q54B37", "sequence": "MLIHPFIQSFTEIIDNRMKLGNNMEGVIECKNCQTDTPKCNKVCLTCNSDIGERCWRCNYLGKINSKFCFRCNVKLHPTSIPPKDSIQPIPIFTKHPIASTLLINKSIIPTQSENNSINDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNNNDSKIIDATITNTKNNNTTNNNNISNNNSSNIISNSNNNNNNNNNNNNNNNNNNNNNNNLNFLKKSTSCDNGSFESISDSISPIKDIINNINNRTKDIEKLNSALPLNKKSNSSTSWSNFNTFKNNSKTNNNNNNNNNNNNNNNNNNNNNNYKPTITSSQTQPSLMENSKDIDKKEKIPSNINNNRSTTIIYKYQEDNSEDYTDDGDFEEFQINSNLTSESSSIDSLIIKDGVIATTVTSSTINCINDNNFDPDQLSSSTSSIKKPKLFYSITKKKLVSQSPPPPQPPFLASASSSSTTTITTTDSLEKSIKDSTPIATTLVNDYQNQNQNLNNESAASSSSLSTTTTTTTTTTTTTLLPDSQTNLNNLIFIEKLNNDLSGSIETLNNSLNNSLNSLNSSFNFRLNLNSITNNEDKRLSNSSLLDEIIDAFPSPPSKNPYISVLNTSGGIGSNSNSSNNNNSNSNNITNSNSSSFSKKNSNNNNNYQPVISLPIPIVNHQQQQQQQQLQTAAILGNNNINFIQNPSSTSTTTTTTTASTTTILIKSDHRTNLIKEILTTELDYVNDLETIINVFCKPLRDFISNEDSASIFSNIEQIWQINKQLYENLISNTLTIGQVFSNMSDSLKVYSVYCNYHQKSLDSLNQLLKTPQNESFFDQLLSKPELRGMGPHSFLIKPVQRICKYPLLLKELLKATAEDHFDYPQLILAVEKIEKIVGTINSQKKEMETWQRTMQLIQNLKGADNLQLLAANRHLILEGSLHLVIGFTENAEKKNSSLKFKKGVYFLFNDLFLFTKQKGTTYKLLFYTQLDNVLIHANVSNCFPADKSVFSLVEIGVGGRKWTFCNTNSNSSNISNSGNSSGIINSSSSSSGSCSNGGNSSGYNNLNNTCGIYSGNSNNNNNNNNNNNNIFSTIQKLIEKTWEDKFMGQSSVSHRLSIPSTSSPNNGASLNGNSSSNSSSTSISTVGSPNVTSAAKQQQQLQQQQQSSKKRNRRLVKSLVNIKT", "function": "GTPase-activating protein.", "AFDB_id": "AF-Q54B37-F1-model_v4" }, { "swissprot_id": "F4I3Z5", "sequence": "MELEQLKKSVEENPDDSSLQFELGLYLWDNGGDSEKAAEHFVLSAKSDPNNAVAFKYLGHYYSRVTLDLNRAAKCYQRAVLINPNDSDSGEALCDLFDRQGKEILEIAVCRDASEKSPKAFWAFCRLGYIQLHQKKWSEAVQSLQHAIRGYPTMSDLWEALGLAYQRLGMFTAAIKAYGRAIELDETKIFALVESANIFLMLGSYRKGVELFEQALKISPQNISVLYGLASGLLSWSKECINLGAFGWAASLLEDARKAAKASSELASSMSCIWKLHGDIQLTYARCFPWSGGTENSEFTLKTFSDSILSWRSICYSAALSAKASYQRALHLAPWQANVYTDIAITCDLVSSLSDDSDTSSSWKLPEKMVLGALLLECENSEFWVALGCMSDNSALKLHALIRALHLDVSLAVAWAFMGQIFRESDEMKFAKQAFDCARSIDPTLALPWAGSADTYARESTSDEAFESCLRAAQISPLAEFQVGLAWLALLQGNISSPQIFACIEQAVQRSPYYPEPHNLHGLVCEARHNYHTAIASYRLALAAMSIYPESSVKSHAGKVSINLVRSLSKAGRFKESVMECANLKSKGLLDAGGLQIYAFSLWRTGQNDSALSVIRDLAGRISTREKTSIAFPISFICSLLYCISGLDSAITSIQKMPKDFFQSSKISFIVSAIHSLDQSDRLQSIVASTRSYITSQEEIVAMHYLIALSKLLKTGAGDFLGYEKGIAHLSKAIHMYPHSNLIRNLLGYILLAGEGMKDACTASRCCIINVSECANKEGLKSALEVLGGGSVACNVIGNTAPRFSFPTCHCQYLNAPVVVVELQRFLHQEPSNSSVRYLLILNLVQKAREQRFPRQLCRAIERLISVALSDETCSKEGEYKKFQLLLCASEISLQMGNIAESINHARKASSLSLPSSYLFLGHLQLCRAYAANGSTKNMQEEYRACLELKTDSNIGWICLKLIESQYNLEPDANLLEMSLQECSSQKKNSWKEWMAVYSLARGLDSTGKKDFFSAEEFLAQACSLLNSESCLLLCHGAVCMELARQSNDSQFLSLAVKSLSKVQASSLFPLPIVYTLLAQAHGSLGSKEKWEKNLRLEWFCWPPEMRPAEVYFQMHILARQSEDRPETTSGIENYQSPEKWVIRAIHTDPSCRRYWKVLDKLVQHPMS", "function": "Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).", "AFDB_id": "AF-F4I3Z5-F1-model_v4" }, { "swissprot_id": "P55869", "sequence": "MQTGLSLACLVLLCSVLGEAALRKPKRQAGATDTNGAAKSEPAPVKTKGLKTLDRGWGEDIEWAQTYEEGLAKARENNKPLMVIHHLEDCPYSIALKKAFVADKMAQKLAQEDFIMLNLVHPVADENQSPDGHYVPRVIFIDPSLTVRSDLKGRYGNKLYAYDADDIPELITNMKKAKSFLKTEL", "function": "Involved in cement gland formation; probably specifies dorsal ectoderm to acquire an anterior fate such as cement gland and forebrain. Signals via the FGF pathway.", "AFDB_id": "AF-P55869-F1-model_v4" }, { "swissprot_id": "P32372", "sequence": "MGSSKPLKGFVICCTSIDLKQRTEISTKATKLGAAYRSDFTKDVTHLIAGDFDTPKYKFAAKSRPDIKIMSSEWIPVLYESWVQGEDLDDGLLVDKHFLPTLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQSIQRNAVLEPQYFQLDMPAEKIGLGAYVRLDPNTTEAKSYSENQKISKNKEKSGQSLAALAEEADLEPVIMKRGKKRDRSILWEELNNGKFEFSSRSEENSVLLDDFTPETVQPLEENELDTELNIENEAKLFKNLTFYLYEFPNTKVSRLHKCLSDNGGQISEFLSSTIDFVVIPHYFPVDELPIFSFPTVNEWWIERCLYYKKIFGIDEHALAKPFFRPSLVPYFNGLSIHLTGFKGEELSHLKKALTILGAVVHEFLGVQRSILLVNTNEPFSMKTRFKIQHATEWNVRVVGVAWLWNIIQSGKFIDQVSPWAIDKKENQEIKKFTNQNNMVFPTSDRDTRLQNSLAQQPIGHSTPHNSPSLLSVKKRQNNHIRSNTLIQLNSNSKDSTIFPRRSVTVPGDKIDTVWKSSVTKPETPTSPQEHVSYIDPDAQREKHKLYAQLTSNVDAIPPANDLQNQENGLLLITESHRKLRRR", "function": "Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Interacts simultaneously with both 'Thr-187' phosphorylation sites in a crb2 dimer for establishing the DNA checkpoint.", "AFDB_id": "AF-P32372-F1-model_v4" }, { "swissprot_id": "O61308", "sequence": "MEGTCSEEENLAKRVTPTAVTSGTYGTHVVDTTDLALSDVVIGCGSTIYETSDSIGSDVMLGLSSHGVSSVSGLDRDLNSFKKRIDANTEEQREHADMMVGLQRKIEEYRRRIVDAEKQVSIQKANDDVSFSIKETADTWLPDMKSDAADYEWASRLDEERRRNDELHMQITQQQVDLQRLQKYFEANMQEKEKIYQTREKNLAYYLNAEQRKMLDLWEELQRVRRQFADYKEQTERDLENQKNEVAKVTQSVGGMAGRLNTSSHGDSGLVQDVVLLEAMRRFRELQAVPVGASADDYNALMKKYEETVERVIELESHGDGSTAKMLSLEAELRRTKDKFIECSEFLRKLGDLAAGSYRGDERTSKIVSLSPGGMSLPSEIYRSVRNILRNHDSEMQHIQRKLKNSDTQVCELTTRLEGTEEARRRSDKQLVDAKREINIQQRAVDDANRELRRVEDRLHIMESEKIVAENARQQLEEEVRRLTLQVDQSKADGERRVVEEGEIQKRIVEDEYRSMISELTRRMNAFQDENKRLKNDLGCTKERLKNVEFEYNSTVRKLEDKDIALKHLEDTKLDLLKDLENQRTRYDAVTNELDTLQTTFETSTKNIAQLEANIKEINLMRDEISKEKDSLAQKLADVTHKLEIETVRREDIQRSCVGHSEDVEKQRLQIIEYEREVMALRRLNDELDTNVKTGQAKVTSLENSIISVQTEVTKLTTLNDKLQKEKQSIMSSKQKADTDVDLLKEKLRKLEQECDKLKEENKALHEDEQIARQMCKEEASRIHLLERDLKDAMTEVEELKKQLQKMDEENSERLESVLRTKISSDTVDTSEIAEYTEVKVKELREKYKADLERLQSNKDDLERRVQILEDELAERQRIVERQRTEMNDLKLEYQLESDRLRAEMATVELKYQSEVEDERDQRSRDADSWKVTSEELRSKISFMEKMLEEAKHRETVLREEATEWEEKHDIISNESLKLRNEIERIRSDAEEDIQKWKKDVHMAQNELKNLERVCETLRSQLTAANDRVASLNTTINEQTSKIRELNSHEHRLEEDLADSRATSSAIENDLGNATGRLRSSEEHNAILQSENRKSKTEIEALKHQIDTIMNTKESCESEVERLKKKIVQTTTITKEQNEKIEKLRIEHDHLERDYREKTKEVDRLKEVEKTFELKVNRARQELDEFSKKLIVTETERNAISGEAQKLDKEVQLVKEQLQYKSDEFHKALDELANAHRISEEGRVNAIHQLEARRFEIDDLKSRLENSEQRLATLQQEYVNADKERGALNDAMRRFQATISRSVVAEEHVDVSTIETQMQKLMSRIEAIERERNEYRDSLNRLKNRCSTSYSSVDRQETVYRTFEERVISAEDERRKVELKLSSMKEMLKSQEEKLKQRDEERRNLKSNIVTFELEARAKDAQIRHLNDLLKRVQAELENSQNDNRALRERQEQYETNRIHLEQRLPTDEGEPRVKALMAAFATERQSLSDSLKKLASQLQISETKNADLRDDAERLKRDLLKAERVEEDLRRNLVEQTEIMRENQQLRSQLGVAQSDLANASGRKQQLEGELAAVRAELRDHKQHLHDAISRIAELQRQLQDANAEKSRLTDRIIGLEKTIGTLRNTETELRAQLSTAADERKALNSELEEMRRRIVQMESEKKDVDNQLEEVNKARIIMTKKIEILETEKHSAELVISETASQREAIERSLNALERENKELYKNCAQLQQQIAQLEMDNGERLIALTTKQKEDHEKFVAAVKAEKVQVERIVENRDRAQKSRIRQLENQLSMMREQLDNERARSHQMSERFIVNETNRRVSSSSFRLSGDAAGVAAATILHPQTDRLDYVFANRSALSSYYTVPTEQHASRGKEAYRTSSTIKSSEGTTRESYTYQSRTVSSNIIEQANGMTSSASGEGMSRAYPPTEVNQGDVTGRKSRPATRKQQMKSTFSE", "function": "May play a role in the organization of the spindle apparatus and its interaction with the centromeres.", "AFDB_id": "AF-O61308-F1-model_v4" }, { "swissprot_id": "Q55724", "sequence": "MGKCSYRFISLQTLTPNSLLDHSPNPTIWAKPLQIGSLTLHSRVLQSPLSGVTDLVFRRLVRRYAPQAMLYTEMVSATEIHHLRTLPQVMEIDPRENPISIQLFDCRPDFMAEAAQKAVAQGAQSVDINMGCPVNKITKKGGGSSLLRQPAVAEAIVKTVVAAVDVPVTVKTRLGWDDGEINIVEFAQRLQDAGAQMLTLHGRTRAQGYNGRARWQWIAKVKQALTIPVIANGDIFSVEAAIACLEETGADGVMCSRGSLGYPFLVGEIEHFFKTGEKRKAPTVAEKLTCAQEHLQMLWEYKGQRGLFQARKHLAWYCKDFPGAAALREQLFQINSVQEGKDLLDQAISTAKLCL", "function": "Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.", "AFDB_id": "AF-Q55724-F1-model_v4" }, { "swissprot_id": "Q6Z3Y6", "sequence": "MASAGGCKKKTGNSRSRSPRSPVVLRRAMLHSSLCFLVGLLAGLAAPSDWPAAAGAAVFLRTLRASNVIFSRSSNRPQQPQLVVVVTTTEQSDDSERRAAGLTRTAHALRLVSPPLLWLVVEEAPAEKHAAPPTARLLRRTGVVHRHLLMKQGDDDFSMQISMRREQQRNVALRHIEDHRIAGVVLFGGLADIYDLRLLHHLRDIRTFGAWPVATVSAYERKVMVQGPLCINTSSSSVITRGWFDMDMDMAAGGERRAAADRPPPETLMEVGGFAFSSWMLWDPHRWDRFPLSDPDASQESVKFVQRVAVEEYNQSTTRGMPDSDCSQIMLWRIQTTL", "function": "Probable beta-1,4-xylosyltransferase involved in xylan biosynthesis in cell walls.", "AFDB_id": "AF-Q6Z3Y6-F1-model_v4" }, { "swissprot_id": "O42504", "sequence": "MNSYFANPSLSCHLSGGQDVLPNVPLNSTTYDTVRHFSSYGAAVTQNRIYAPFYSPQDNVVFGSGRAQYDYGSNVFLQDKDVLPSCRQTNMGLSTQSHIAQEYSLDQGRTGTQEQKSNIPIYPWMQRMNSHSGVGYGTDRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTVTGSEQTGGSQEEREDRGGATEEGKDEDKKKE", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.", "AFDB_id": "AF-O42504-F1-model_v4" }, { "swissprot_id": "Q94177", "sequence": "MNPDEVNRALGHYLNDADSGELVVEDSTTVQVKNPEARKTGDKIEVFYSRKTTVVSPTNSDDEDADFCSDSELLPQQEGHRSRATSFAGRIRAGSDDEAMPKHTILRYRRKKGGQWREINLQGTPDKRKDDEDELEVDVKEDRSEQTGIVTKTYEARWKVLKYEHLPEWLQDNEFLRHGHRPPLPSFSECFKSIWSLHTETGNIWTHLIGCVAFFFLACWFLTRPDNHIQFQEKVVFSFFFAGAVLCLGLSFAFHTLSCHSVNVVKIFCKLDYMGISLLIIGSFIPWIYYGFYCRREPKITYIAMVSVLGIGAIVVSLWDKFSESRFRPIRAAVFVGMGCSGVIPTIHYIITDGVHSLFADNSFHWLLLMAFLYLLGAGLYATRTPERFFPGKCDIWFQSHQLFHTCVVIAAFVHYYGISEMAFARLNEQCPVR", "function": "Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation.", "AFDB_id": "AF-Q94177-F1-model_v4" }, { "swissprot_id": "Q9ZKP2", "sequence": "MALVKEVLEVLNRLSPFELQESWDNSGLNVGSGNSEFSQIIACLEITLQIALNAQENALIITHHPLIFKPLKTLNDEAYPGNILKILIQKNISVISMHTNFDKTHLNKHFARALLRFDGLIEKGLMLVKENANIEFDVLLEKIKLSLGVGQLACVKSSQMIKDLAFVCGSGASMFSSLKAQSCLITGDVKYHDAMIAQSLGISLIDATHYYSERGFALIVAEILHSFNYLVTIENFKNPLQII", "function": "Converts GTP to dihydroneopterin triphosphate.", "AFDB_id": "AF-Q9ZKP2-F1-model_v4" }, { "swissprot_id": "D3ZZW6", "sequence": "MSLVSPSPDSNAVMAGDQDASTSQVPSQSESKIGPNVATQTLRKPTMSKVILRTVADKGVHSRVSLAALKKAVSITGYNMAQNTWRFKRVLQNLVKKGMLKQVTGKGASGSFRLGKKQAFKSKCKAKRRQRRQKPGQRRTGSRRSLLGSKKSNNRLFKGVRRVAKGRRH", "function": "DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.", "AFDB_id": "AF-D3ZZW6-F1-model_v4" }, { "swissprot_id": "Q9CCK2", "sequence": "MTSSDSHRSAPSPEHGTASTIEILPVAGLPEFRPGDDLSAALAAAAPWLRDGDVVVVTSKVVSKCEGRLVPAPEDTRGRNELRRKLINDETIRVLARKGRTLIIENGLGLVQAAAGVDGSNVGRGELALLPVNPDASAAVLRIGLRAMLGVNVAVVITDTMGRAWRNGQTDVAIGAAGLAVLHNYSGAVDRYGNELVVTEIAVADEVAAATDLVKGKLTAMPVAVVRGLSPTDDGSTAQHLLRNGPDDLFWLGTTEALELGRQQAQLLRRSVRQFSDEPIAAELIETAVAEALTAPAPHHTRPVRFVWLQTPAVRTRLLDRMADKWRLDLASDALPADAIAQRVARGQILYDAPEVIIPFMVPDGAHAYPDAARASAEHTMFIVAVGAAVQALLVALAVRGLGSCWIGSTIFADDLVRAELELPADWEPLGAIAIGYAHEPTDLREPVRVADLLLRK", "function": "Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.", "AFDB_id": "AF-Q9CCK2-F1-model_v4" }, { "swissprot_id": "Q6AF82", "sequence": "MEGRIRVTEFLLSVPAIGTTKTQDALRRLGIAPSKRLGGLGRHQRLRLRVFLIEREERPVRRRKHLVVLAGPTAVGKGTVSAYIRENYPEVLLSVSATTRSPRPGEVDGVNYYFVDDAAFDRMIAAGDLLEHATVHNAYRYGTPRAPIEKALDDGRSVLLEIDLQGARQVRASMPEARLIFLLPPTWEELVRRLTGRGTEDAAEQQRRLETAKVELAAQNEFDHRVVNHTVADAAREVVDLMMVRPAPVRPSTA", "function": "Essential for recycling GMP and indirectly, cGMP.", "AFDB_id": "AF-Q6AF82-F1-model_v4" }, { "swissprot_id": "P25718", "sequence": "MKLAACFLTLLPGFAVAASWTSPGFPAFSEQGTGTFVSHAQLPKGTRPLTLNFDQQCWQPADAIKLNQMLSLQPCSNTPPQWRLFRDGEYTLQIDTRSGTPTLMISIQNAAEPVASLVRECPKWDGLPLTVDVSATFPEGAAVRDYYSQQIAIVKNGQIMLQPAATSNGLLLLERAETDTSAPFDWHNATVYFVLTDRFENGDPSNDQSYGRHKDGMAEIGTFHGGDLRGLTNKLDYLQQLGVNALWISAPFEQIHGWVGGGTKGDFPHYAYHGYYTQDWTNLDANMGNEADLRTLVDSAHQRGIRILFDVVMNHTGYATLADMQEYQFGALYLSGDEVKKSLGERWSDWKPAAGQTWHSFNDYINFSDKTGWDKWWGKNWIRTDIGDYDNPGFDDLTMSLAFLPDIKTESTTASGLPVFYKNKMDTHAKAIDGYTPRDYLTHWLSQWVRDYGIDGFRVDTAKHVELPAWQQLKTEASAALREWKKANPDKALDDKPFWMTGEAWGHGVMQSDYYRHGFDAMINFDYQEQAAKAVDCLAQMDTTWQQMAEKLQGFNVLSYLSSHDTRLFREGGDKAAELLLLAPGAVQIFYGDESSRPFGPTGSDPLQGTRSDMNWQDVSGKSAASVAHWQKISQFRARHPAIGAGKQTTLLLKQGYGFVREHGDDKVLVVWAGQQ", "function": "Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, MalF, MalG, and MalK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the MalS protein.", "AFDB_id": "AF-P25718-F1-model_v4" }, { "swissprot_id": "P39859", "sequence": "MQLLFVHDFPVEKYKDNYYSIGFSHKIWNRYLTIFDKMLINSRVKNVDNGEIINKSNGEKVNFKTIDSYKSPKSLIFKHKKIFEALTISIKKSDGVLIRVPSVLGFIAALICKKINKPYMVEVVGAAFDAYWFHGSIFGKILSLPMEYLQKNAVKNASIAIYVTKKYLSNKYPCNGKEFKGISNVQSVEKFNKNLDIGNKIKIGLIGSTFVDYKGHNVAIKSISNLVNEGYNIELEFVGDGPSKKFMEMAKKYNVENNVIFKGKIYDKTALNNWFRNLDLYIQPSLTEGHCRAIVEAIGNGVPTLASNAGGNSDSVNKEYLFKPKDVVKLTKLINRSILSKQYREENVLENKKNISGYNLENIQIEREKALLNYKKIINDFYLAKGINKNA", "function": "Required for the biosynthesis of type 1 capsular polysaccharide.", "AFDB_id": "AF-P39859-F1-model_v4" }, { "swissprot_id": "Q8ZA49", "sequence": "MAYKHILIAVDLSPESKVLVEKAVSMAKPYNAKVSLIHVDVNYSDLYTGLIDVNLGDMQKRISEETHNALTELSQNAGYPVEQTLSGSGDLGQVLVDAIKKYDIDLVLCGHHQDFWSKLMSSARQLINTVHVDMLIVPLRDDENGEDD", "function": "Required for resistance to DNA-damaging agents.", "AFDB_id": "AF-Q8ZA49-F1-model_v4" }, { "swissprot_id": "P49340", "sequence": "MKCLWLLVITVLCLRCDTAGTKPRRGRGSMWWGIAKAGEPNNLSPVSPGVLFMDPAVHATLRRKQRRLARENPGVLAAVAKAQYAFAECQHQFKYRRWNCSTRNFLRGKNLFGKIVDRGCRETAFIYAITSAGVTHSLARACREASIESCTCDYSHRPRAAQNPVGGRANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKTLREKMNLHNNEAGRRHVQTEMKQECKCHGMSGSCTVKTCWMRLPSFRSVGDSLKDRFDGASRVMLSKADVETPAQRNEAAPHRVPRKDRYRFQLRPHNPDHKSPGVKDLVYLESSPGFCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTNTMFVVERCNCTFHWCCEVKCKLCRTEKVVHTCL", "function": "Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.", "AFDB_id": "AF-P49340-F1-model_v4" }, { "swissprot_id": "E7FHF1", "sequence": "MKARIIYRASFDAAHAVKIEEWEELHGHTFSLEVVVEGEIKKGYVMDFLKLKKVVDGVVKELDHRNLNKIMDNPTTENIALWISERIRKNLPGDVKLKRLSLWEGNEFGVELEW", "function": "Catalyzes the conversion of 7,8-dihydroneopterin monophosphate (H2NMP) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). Cannot use 7,8-dihydroneopterin (H2Neo) or 7,8-dihydroneopterin triphosphate (H2NTP) as substrate.", "AFDB_id": "AF-E7FHF1-F1-model_v4" }, { "swissprot_id": "Q9Y942", "sequence": "MASEIPYDESPSGEESGEIKCKNIVTDPVRGLKICADTGEIIGEDIIGTESDVKAYTPEERQQKTHYGGPLKYSHHYMGVEASLEHPRDHGPKGIKQRKILPRRPPRLSARPLTSVDKNLQTALSLINEVASRMGMPEIVVEDASKIYREAMEKGLTRGRSIESIVAASLYAASRIHGLPHSLTDIIKAMKGNVDAETRRDVARSYRLLVRDLNIKIPVRKPENFVYTIISALGLPEHVAIEAIKIIDLSRKKGLTAGKDPGGLAGAAVYLAALKHGIRKTQKEIAHVVGVTEVTIRNRYKEIAQALGIEEELEEKGGEEKG", "function": "Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).", "AFDB_id": "AF-Q9Y942-F1-model_v4" }, { "swissprot_id": "O27744", "sequence": "MIVLNDRIIPWQPTVIAGPKQAMLVTPETATMMIKKARRPLMVVGPLAKRQEVLEHTVKIIRHFDLPVVATADTYRALSEAGIESEPHGIVEITNLLKDPSWEGIRGEGQHDLVIFIGCIYYIASQGLSSLKHFAPHIKTLTICKTFHSNADASFPNMDDDEWFRYLEKMYAE", "function": "Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.", "AFDB_id": "AF-O27744-F1-model_v4" }, { "swissprot_id": "Q84TH5", "sequence": "MSAFDGVENQMNGPDSSPRLSQDPREPRSLLSSSCFPITLKFVDVCYRVKIHGMSNDSCNIKKLLGLKQKPSDETRSTEERTILSGVTGMISPGEFMAVLGPSGSGKSTLLNAVAGRLHGSNLTGKILINDGKITKQTLKRTGFVAQDDLLYPHLTVRETLVFVALLRLPRSLTRDVKLRAAESVISELGLTKCENTVVGNTFIRGISGGERKRVSIAHELLINPSLLVLDEPTSGLDATAALRLVQTLAGLAHGKGKTVVTSIHQPSSRVFQMFDTVLLLSEGKCLFVGKGRDAMAYFESVGFSPAFPMNPADFLLDLANGVCQTDGVTEREKPNVRQTLVTAYDTLLAPQVKTCIEVSHFPQDNARFVKTRVNGGGITTCIATWFSQLCILLHRLLKERRHESFDLLRIFQVVAASILCGLMWWHSDYRDVHDRLGLLFFISIFWGVLPSFNAVFTFPQERAIFTRERASGMYTLSSYFMAHVLGSLSMELVLPASFLTFTYWMVYLRPGIVPFLLTLSVLLLYVLASQGLGLALGAAIMDAKKASTIVTVTMLAFVLTGGYYVNKVPSGMVWMKYVSTTFYCYRLLVAIQYGSGEEILRMLGCDSKGKQGASAATSAGCRFVEEEVIGDVGMWTSVGVLFLMFFGYRVLAYLALRRIKH", "function": "High affinity abscisic acid (ABA) transporter that mediates the export of ABA, with a preference for (+)-ABA, through the plasma membrane, especially in vascular tissues (e.g. phloem companion cells), and is involved in the intercellular ABA signaling pathway. Together with ABCG31, export ABA from the endosperm to deliver it to the embryo via ABCG30 and ABCG40-mediated import to suppress radicle extension and subsequent embryonic growth.", "AFDB_id": "AF-Q84TH5-F1-model_v4" }, { "swissprot_id": "O05403", "sequence": "MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTSAAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALSGLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRRNIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPNKIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISNLLVGERYIR", "function": "Anti-sigma factor for SigV. Negatively regulates SigV activity through direct interaction.", "AFDB_id": "AF-O05403-F1-model_v4" }, { "swissprot_id": "Q02969", "sequence": "MSQFGTTDIVSGSETPPYSGASYQDAQDDNTHPHSSDAGAEKFSAGSGSESHTESSRSDDEDSQAKTKMVDNITILKYILDSLSGRDKLAKIIKYALDILKLFIEKSKRNLTVLDPSVLTYYTKILKNLTVKVALRHPITVIKVLLLSLLRNFDKKIDFISQQLSTFRYILRFGGTPFRVCSFLGKFNKTRKCNFQIDQIKKIWFNEASLREFLDLYYGIFDELDLLYKLKIWTNKSFYSFVSRQESLAWQYDILLSLKDHWLNLQSLQKRQLELEVQLKVQNNALLLSPILMHQAHKDDGSQSPIRKQLLNDLNVNNDAEVLIHKQLKAIKDEKTLVYLDIARLSFDCMANTSDILNLKTPKGTYAVLSLGSGLTGLVKLWITTKRSLCSSKD", "function": "Required for regulation of peroxisome size and maintenance. Has a role in the import of peroxisomal matrix proteins. Imports RHO1 into the peroxisome. Also promotes peroxisome division and biogenesis.", "AFDB_id": "AF-Q02969-F1-model_v4" }, { "swissprot_id": "Q8GWP5", "sequence": "MQISCLPISIPSITPRTSIPLLPSLSSNPRRIFNLTSLQSPNHCFFKRLHKSQTGFSNPVLAAMRREEDVEVDDSFYMRKCVELAKRAIGCTSPNPMVGCVIVKDGDIVGQGFHPKAGQPHAEVFALRDAGELAENATAYVSLEPCNHYGRTPPCTEALIKAKVRRVVIGMVDPNPIVFSSGISRLKDAGIDVTVSVEEELCKKMNEGFIHRMLTGKPFLALRYSMSVNGCLLDKIGQGASDSGGYYSKLLQEYDAIILSSSLSDELSSISSQEAINVSIQPIQIIVASNAQQSHILASSHTVEESGPKVVVFTAKESVAESGISSSGVETVVLEKINLDSILDYCYNRGLCSVLLDLRGNVKDLEVLLRDGFEQKLLQKVIIEVLPEWSTKDERQIASMKWLESKHVKDLQSKQLGGSVLLEGYF", "function": "Monofunctional pyrimidine deaminase involved in the riboflavin biosynthesis pathway. Has also a reductase domain that lacks catalytically essential substrate-binding residues.", "AFDB_id": "AF-Q8GWP5-F1-model_v4" }, { "swissprot_id": "P44413", "sequence": "MSFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKKPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL", "function": "A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GTYRAC-3' and cleaves after Y-3.", "AFDB_id": "AF-P44413-F1-model_v4" }, { "swissprot_id": "Q9ERQ6", "sequence": "MGRAGGGGPGWGPPPVLLLLGVTLVLTAGAVPAREAGSAIEAEELVRSGLAWESRANDTREEAGLPAAGEDETSWTERGSELAAVGPGVGPEETLEASAAVTGTAWLEADGTGLGGVTAEAGSGDAQTLPATLQAPDEALGSSTMPPAIPEATEASGPPSPTLRDKPSLVPELPKEIPLEVWLNLGGSTPDPQRPEPTFPLQGTLETQPASDIIDIDYFEGLDSEGRGTDMGRFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLEEEEEEEEDKDAVGGGDLEDESDLLLPSQKPGVGPGTGQPTSRWHAVPPQHTLGMVPGGSISLRPRPGDPGKDLATSENGTECRVGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCDTPCVSSPHARALAHCDNIVCQDDPSAPHKIQEALKSRLKEEESFNIQNSMSPKLEGGKGDQDDLEVNCLQNNLT", "function": "May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.", "AFDB_id": "AF-Q9ERQ6-F1-model_v4" }, { "swissprot_id": "Q3YST7", "sequence": "MKRSDKELHLSKVEGLFSKFKYFIIANFQGMVANDFFSLRKELKMANSGLMVVKNSLSRIALKKMGREELSAKFFGSIFIVYSDDIILISKILAKFMKDNKSKISLLCAYDSNEILDSEKVLYFASLPSLRELHAQIMSMISYNIPVRLALCLKALGNKE", "function": "Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.", "AFDB_id": "AF-Q3YST7-F1-model_v4" }, { "swissprot_id": "A1RZT8", "sequence": "MRLLVLRGVDEVTVSSRSTVVIKSGNRVFERALRDVDAVLVVGSGIKISSSLPPVLALHGIPLSILAKGHVAVLLNPVGTKYNNYRALQYTLPKNKALAIALEYLKSRVRGMASIIRNRGGRLPALPEPPDPALYEDPARLESDIRSWEAAASNTLWDEVFKLLDPSAARELRERYGFAGRKPGHPDPLNKAISAMYAVLYTLSTKALVAAGLDPTYGFLHRTQYSVPLAFDYAEAFKPLAVEAALDLVNEEGLPTLSEDGDLDKDSLNKAMKRLYRYLSAKHRETGKTPYQQIHLKAFCLAKHLEGKCSREKLAFTWDKKRYIIHE", "function": "CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.", "AFDB_id": "AF-A1RZT8-F1-model_v4" }, { "swissprot_id": "Q98SN7", "sequence": "MLSPNRLAASPGIAVAPGRAECGAFPRTAGAAPRICLPFVLILLALTPRADSSWWYIGALGARVICDNIPGLVNKQRQLCQRYPDIMQSVGEGAKEWIRECQYQFRHHRWNCSTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVYAITRACSQGELKACGCDPLKRGRAKDERGEFDWGGCSDNINYGIRFAKAFVDAKEKKVKDARALMNLHNNRCGRMAVKRFLKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLQKKYNGAIQVIMNQDGTGFTVANKNFRKPTKTDLVYFENSPDYCVMDKSAGSLGTAGRVCNKVSRGTDGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEDTVDVHTCKAPKRAEWLDQT", "function": "Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo.", "AFDB_id": "AF-Q98SN7-F1-model_v4" }, { "swissprot_id": "M1RNJ8", "sequence": "MGFKDKILFWKDEVQYRTLAVADQVANRFLHSFENVYQGDESVEDADSRPVGLTNETLSHSSDFFVLPEERISTRVKIRRQNILNTTLILGMLIALVIWTAILSTNSYFSSSLASASPLFNKEGRVVRPMRESNLGLHADPQTRKSSKTLYDLLSDFDNAFYDDENMILGSLAFGENTYSRQPYVANGYIGSRIPNIGFGYALDTLNLYADAPGALNNGWPLRNRRFAGSFVSDFYSLQAKLNSTNFPELDEKGYTTVISSIPEWTDLQFTVDLNGTKWFNPQSVLIDDVINYNQNLSMKDGIVSTNMDWLNGMINIKSEVWAHRKIHSLGITRLEISLNLDALPDEFTELPVTVYDIIDLNTSHRTTLYEKGQDEDNKAIYMIVNPDNVPYSNAVVYSTCTIKGTENNFSPYNFTSDDRIARNYMTNLTEENPKVVIYKYTSVVSSEYNNDEPNPNVNLKFASNIANTAKGNYKSLLSNHKRAWYDLYNDAFIEIPSDSLLEMTARSSLFHLLANTRQYNVSTTRGLPVGVGGLSSDSYGGMVFWDADVWMAPALLPFFPNIAMNMNNYRNATHQQAIENAKQYNYPGAVYPWTSGRYANCTSTGPCIDYEYHINVDIALASFSIYMNGAEGADEDYLRFTTWPMVKDAAVFFKAYVKYNETLGEYETYNLTDPDEFANHVNNGAFTNAGIKTLLKWATDIGTHLGEEVDPKWMEIADNIHIPRSDSNITLEYSGMNSSVEIKQADVTLMVYPLGYINDESILNNAIKDLYYYSERQSASGPAMTYPVFVAAAASLLNHGSSSQSYLYKSVLPYLRSPFAQFSEQSDDNFLTNGLTQPAFPFLTANGGFLQSILFGLTGLRYSYEVTPRTKKISRLLKFDPVKLPLLPGGIAIRNFKYMGQVLDIIIDDNNGTIAHKGGDKPIRIKVPNRDILHDRNITSALYSKRDDDLSATDDYYGTYFTLYPNEELVIPLYDTKLNIDGNIAESKQITNLTAGVPGDVGFSALDGNNYTHWQPFDKSDNAKLLIDLGFNSTHVIKKGIILWGQRPAKNISLSVLPHSERIEQLFANITDLLETSSITKGGLPLNQMLGQTQSNVTAEIDDDILALLNWKGDDLDQLIPYLPDMHLLQEKFIPILKDYPIKPNQRYYEEIIDDDIIKLLPSNTTEFTIDYNSIPGGEKRARYVVLTVHGTYDDDDDLKGATIREIVLQE", "function": "Periplasmic/secreted acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source. Growth on trehalose is not restricted to respiration.", "AFDB_id": "AF-M1RNJ8-F1-model_v4" }, { "swissprot_id": "Q9SJ74", "sequence": "MATLILSFLLLLLATKLPESLAGHCTTTTATKSFEKCISLPTQQASIAWTYHPHNATLDLCFFGTFISPSGWVGWGINPDSPAQMTGSRVLIAFPDPNSGQLILLPYVLDSSVKLQKGPLLSRPLDLVRLSSSSASLYGGKMATIRNGASVQIYASVKLSSNNTKIHHVWNRGLYVQGYSPTIHPTTSTDLSSFSTFDVTSGFATVNQNSGSRALKVTHGVVNAISWGFLLPAGAVTARYLRQMQSIGPTWFYIHAAIQLTGFLLGTIGFSIGIVLGHNSPGVTYGLHRSLGIATFTAAALQTLALLFRPKTTNKFRRYWKSYHHFVGYACVVMGVVNVFQGFEVLREGRSYAKLGYCLCLSTLVGVCVAMEVNSWVVFCRKAKEEKMKRDGLTGVDRCSGSHS", "function": "May act as a catecholamine-responsive trans-membrane electron transporter.", "AFDB_id": "AF-Q9SJ74-F1-model_v4" }, { "swissprot_id": "P0A333", "sequence": "MPPMLSGLLARLVKLLLGRHGSALHWRAAGAATVLLVIVLLAGSYLAVLAERGAPGAQLITYPRALWWSVETATTVGYGDLYPVTLWGRLVAVVVMVAGITSFGLVTAALATWFVGREQERRGHFVRHSEKAAEEAYTRTTRALHERFDRLERMLDDNRR", "function": "Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel.", "AFDB_id": "AF-P0A333-F1-model_v4" }, { "swissprot_id": "B5TVM2", "sequence": "MPAFPTLDLDGKLGKMDRVVLGWTAVFWLTAMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSPRAQALSKRNLEWDPYLDCLDSRRTVRVVASKQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVILGIFLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHDDDSNFRQSYHQMRNKQFPMSGDLESNPDYWSGVMGGNSGTNRGPALEYNKEDRESFRHSQQRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRSRRANGNSHEARAGSRFERSESRAHGAFYQDGSLDEYYGRGRSREPPGDGERGWTYSPAPARRRPPEDAPLPRLVSRTPGTAPKYDHSYLSSVLERQARPESSSRGGSLETPSKLGAQLGPRSASYYAWSPPTTYKAGASEGEDEDDAADEDALPPYSELELSRGELSRGPSYRGRDLSFHSNSEKRRKKEPAKKPGDFPTRMSLVV", "function": "May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions. Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1.", "AFDB_id": "AF-B5TVM2-F1-model_v4" }, { "swissprot_id": "Q09312", "sequence": "MDQSKMRRTNQFRKTSQKPPSTGIDSYPTPAQSPMAQHETPMWDFNSLNPYFSMLNMNDGINYARHQQNHIVTSRPPTPLTDLMSLRSFQSFPNVFMPVSRSRTSSFIQSDTDSSRLESDDFSQNVRCFSADIDRSKSYGSSKHYHLKYSRPALSRNSRSFTRSNNVLPTWSLDSNGEMRSRLSLSEVLDSGDLMKFAVDKTGCQFLEKAVKGSLTSYQKFQLFEQVIGRKDDFLKLSTNIFGNYLVQSVIGISLATNDDGYTKRQEKLKNFISSQMTDMCLDKFACRVIQSSLQNMDLSLACKLVQALPRDARLIAICVDQNANHVIQKVVAVIPLKNWEFIVDFVATPEHLRQICSDKYGCRVVQTIIEKLTADSMNVDLTSAAQNLRERALQRLMTSVTNRCQELATNEYANYIIQHIVSNDDLAVYRECIIEKCLMRNLLSLSQEKFASHVVEKAFLHAPLELLAEMMDEIFDGYIPHPDTGKDALDIMMFHQFGNYVVQCMLTICCDAVSGRRQTKEGGYDHAISFQDWLKKLHSRVTKERHRLSRFSSGKKMIETLANLRSTHPIYELQSSGHDSFKTDYFSTASEHDGPELEKNGIEEGSLMLEPRSNKSSVSVKFSSSGSHGDD", "function": "Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform b 3'-UTR. Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes.", "AFDB_id": "AF-Q09312-F1-model_v4" }, { "swissprot_id": "P0DO96", "sequence": "MGKIFIIDVTNRDGVQTARLGLSKLEKTLINIYLDEMGIFQSEFGFPTTKHERGYVEANLELAKMGVIKNLRLEGWIRAIVADVDLAFRRAPSLKHLNLSISTSEQMINGKFQGRKVFKDIIEDMTIAVNAAYAKGAETVGVNAEDASRTSIVNLIEFGKAAKEVGATRLRYCDTLGYDNPFTIYETARTLAEKVGMPIEIHCHGDLGMAIGNSLAGAKGVIDGGQDVYVNTTVNGIGERAGNADLVAFLLAILKSKGFGEKYQLGHEVDLSKAWKIARFASYAFDVEIPINQPGVGRNCFAHASGIHADGVIKDSQNYELYGYEELGRGEALMVETGREICAGQYSGISGFRHVMGNMSVELPEDKDEANKILELVRYANVEAHKPLVEDELIFIAKYPEISRRLLTLTPLMND", "function": "Catalyzes the condensation of the acetyl group of acetyl coenzyme A (acetyl-CoA) with oxaloacetate to form citrate. This enzyme is highly Re-face stereospecific with respect to the C-2 of oxaloacetate.", "AFDB_id": "AF-P0DO96-F1-model_v4" }, { "swissprot_id": "Q8CGK5", "sequence": "MWRADRWAPLLLFLLQSALGRPRLAPPRNVTLFSQNFTVYLTWLPGLGSPPNVTYFVTYQSYIKTGWRPVEHCAGIKALVCPLMCLKKLNLYSKFKGRVQAASAHGRSPRVESRYLEYLFDVELAPPTLVLTQMEKILRVNATYQLPPCMPSLELKYQVEFWKEGLGSKTLFPDTPYGQPVQIPLQQGASRRHCLSARTVYTLIDIKYSQFSEPSCIFLEAPGDKRAVLAMPSLLLLLIAAVAAGVAWKIMKGNPWFQGVKTPRALDFSEYRYPVATFQPSGPEFSDDLILCPQKELTIRNRPAPQVRNPATLQAGPERDSTEDEDEDTDYDDDGDSVQPYLERPLFISEKPRVMEHSETDESGVDSGGPWTSPVGSDGSSAWDSSDRSWSSTGDSSYKDEVGSSSCLDRKEPDQAPCGDWLQEALPCLEFSEDLGTVEEPLKDGLSGWRISGSLSSKRDLAPVEPPVSLQTLTFCWVNNPEGEEEQEDEEEEEEEEEEEDWESEPKGSNAGCWGTSSVQRTEVRGRMLGDYLVR", "function": "The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.", "AFDB_id": "AF-Q8CGK5-F1-model_v4" }, { "swissprot_id": "O93852", "sequence": "MTDIPESLKPFVTKKVIHSTWAGTFLCKPQAIFQPRNVEEIQELIKQARLHGKTIMTVGSGHSPSDLTMTTEWLCNLDKFNHVLLEEPYYAPKSPTDDTPEIKFVDLTVEAGTRIFELNEYLKRNNLAIQNLGSISDQSIAGLISTGTHGSTQYHGLVSQQVVSVKFLNSAGELITCSSVDKPEYFRAILLSLGKIGIITHVTLRTCPKYTIKSKQEIINFETLLNNWDNLWLESEFIRIWWFPYTNKCVLWRANKSTDPLSDPRPSWYGTKLGRFFYESLLWVSVHLFPRLTPFVEKFVFGQQYGEVETLGKGDIAVQNSVEGLNMDCLFSQFVNEWSSPLNSGPEILTELKKIITDASQTGDFFVHAPIEVRCSNVTYSDEPFTDDKNQKSLYPSQEWLSNRSKTSAGPIPGNNLRPYLDNSPKLPYSKDGKITNDQLTLFINATMYRPFGTNVETHKWFQLFEDVMSKAGGKPHWAKNFIGLTQDEKYDKQQDLKTQLEFGGKPFYTMLGFKPVMQDWFGKDLVAFNKVRKETDPDGVFLSGKVWAERNGILLD", "function": "D-arabinono-1,4-lactone oxidase that catalyzes the final step of biosynthesis of D-erythroascorbic acid, an important antioxidant and one of the virulence factors enhancing the pathogenicity. Is also able to oxidize L-galactono-1,4-lactone, L-xylono-1,4-lactone and L-gulono-1,4-lactone.", "AFDB_id": "AF-O93852-F1-model_v4" }, { "swissprot_id": "P48013", "sequence": "MEFVVSNTNLRDLSRIFLNLSRIDDAVNWEINKDQLILTTLNSSRSGFGKVTLTKKFFDKFTFHPDTLFLTGFVSPTVRLSTQIKPILSIFRNKIFESTLLVNNNLNTNAGAAESSSKKNVVVENIQMQITSGKECRVIFKFNCKHGVVKTYKIAYEQTQTLHAVFDKASCHNNWQINSKILKDLIEHFGQKTEELTIQPVQGRVLLTSFTEEVVHNKDVLKQPTQTTVSIDGKEFEQVSLNEGIIITLSLKEFRAAVLLAESLGTSIASYYSVSGKPALFTFNKGKFMEIEAQFILATVMGPDDFDESSLGARWQQSGTANSSLLVPENTSAAPALENEAPSASIGWQTNGDAETSRMFHSTLDIPRNEEPAAKPSRQTTDEENHPLFLEGMPDETELMAFDNDVADDAEFGPTQHEQTYHGIFSQDDTET", "function": "Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.", "AFDB_id": "AF-P48013-F1-model_v4" }, { "swissprot_id": "F4K460", "sequence": "MDSDMEISLDRLPIKRLESIEENGAERFPSDVDYDDKRVSLIRRIDFAWALEEEDELKKKKQKKSSKDSVEQWKWKGMVENLQLAHQELTVIIDLIDTVQANDAVTVAGMTRPKPMPNEILSDLAVSTATKLQGYRNLGNYFKQSAKALEQKINREARFYGALIRLQRNWKVKRQRMLASNASNEGFTIDLSDSSLYDPTSGFRPSTLSTIRVDHDSAGMLAINVPQDSWYSLRFGYVGLNPIGNSNESDEHIDSTTGHDIPGTSEKLSASDDKYVKETHSLLREVHKSIFAEQLFDMLNREAFNEGVGFNISGLRENFMEMSIGQGASLFVSLHPSGKNPSIKKSESATLLIESSGRVEPAEGGDYRLKKLGFPNRTSYEIYLQQIFHEHAFGKAKDQLKSKSIRASNQTEKDSNSGLLDHFCLSLTHRIFSNRVLVHLESVVCKVPYLHLISHPTWNSRTSSWTVFMTVPPSIIPQGRSETQSPDGKRNLKTQFRTKVVVKDDCISVEAECTPNVVGLLKSSSCNLFSINKYECDVADLPVMILQQVASQIVCWLLEEARTVGTKASREFLSLSLEIVEGERVSLVAHVNPEDAKGCISWWLVMENGCTEEREGVSESRKLLGHLSLDVLYSVLMDLINLCGTGRNALERL", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.", "AFDB_id": "AF-F4K460-F1-model_v4" }, { "swissprot_id": "Q8R5K5", "sequence": "MAAAFRKAVKSRQREYRERSQPGFRKHLGLLEKKKDYKLRADDYRKKQEYLKALRKKALEKNPDEFYYKMTRVKLQDGVHIIKETKEEVTPEQLKLMRTQDVKYIEMKRVAEAKKIERLKSELHLLDFQGKQQNRHVFFFDTKKEVEQFDVAAHLQTAPELVDRVFNRPRIETLQKEKVKGVTNQTGLKRIAKERQKQYNCLTQRIEREKKLFVIAQKIQTRKDLMDKTQKVKVKKETVNSPAIYKFQSRRKR", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA.", "AFDB_id": "AF-Q8R5K5-F1-model_v4" }, { "swissprot_id": "P43456", "sequence": "MEYHELNPLIRGRELELISKDTFEQMIQTDSIDSLGEILQSTIYQPYIYDGFDKDFEANLSQERSKLFQWLKESAPEPEIVWIYTMRYTFHNLKVLTKAEITGQNLDHLYIHDGFYSLEVLKDAIHTQVSVELPDSLMDYIREVHEYCEESTILQGIDVIYDRCFLTEQRRLGEQLGYPELLEEIIAFIDLTNITTTARGILQHRSAGFMTTVISSSGSIPKDTLLSFVRGEMASFTQFLLTTDYSELLKQVIHEEQIDLVSLEQLKDDYLSSFYQVAQTQAFGPLPLLAFLNAKEVESKNLRLLIIGKRNHFSLEQLKERMRQVYDL", "function": "Involved in ATP-driven sodium extrusion.", "AFDB_id": "AF-P43456-F1-model_v4" }, { "swissprot_id": "Q27893", "sequence": "MWLPVYVPLLLVFGVSLSLPQGSLGTDSSSLRGVDADTEKRINVGKKHLQTLRNLETRCHDSLQALVVIDAGSSSTRTNVFLAKTRSCPNKGRSIDPDSIQLIGAGKRFAGLRVVLEEWLDTYAGKDWESRPVDARLLFQYVPQMHEGAKKLMQLLEEDTVAILDSQLNEKQKVQVKALGIPVMLCSTAGVRDFHEWYRDALFVLLRHLINNPSPAHGYKFFTNPFWTRPITGAEEGLFAFITLNHLSRRLGEDPARCMIDEYGVKQCRNDLAGVVEVGGASAQIVFPLQEGTVLPSSVRAVNLQRERLLPERYPSADVVSVSFMQLGMASSAGLFLKELCSNDEFLQGGICSNPCLFKGFQQSCSAGEVEVRPDGSASVNEDVRKNRLKPLATYCSVNNPEISFKVTNEMQCRENSIDPTKPLAERMKIENCSIIKGTGNFDKCVSQVESILVAPKLPLPANIEAASSGFESVDQVFRFASSTAPMIVTGGGMLAAINTLKDHRLLRSDFSGDVEELAEAAREFCSSEVIIRTDGPVIQLPNARGEQKLNSLNFDLCKTMALTVSLLRHMAAGENQPSFIKWEKSIAGPDGKPLADLGWQVGVILHHVLFTEEWGRNAYEAGYSHNL", "function": "May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite and may contribute to intracellular survival and virulence. NTPAse-I has a specific activity 4.5-fold higher than NTPAse-II in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).", "AFDB_id": "AF-Q27893-F1-model_v4" }, { "swissprot_id": "A0LV52", "sequence": "MADGEGGAASAPTAGTRPVYRRVLLKLGGEMFGGGHVGVDPDIVASIARQIAAVVAEGVQMAVVIGGGNFFRGAELSVRGMDRARSDYMGMLGTVMNCLALQDFLEKLGVDTRVQTAITMGQVAEPYIPRRAIRHMEKGRVVIFGAGLGAPYFSTDTTAAQRALEIGAEVVLMAKAVDGVYDSDPKTNADAVRFDHLDYDEVLARDLKFADATAISLCRDNGMPIIVFNLLEEGNIARAVHGEKIGTIVSSGDGVPPRRQAVSPAR", "function": "Catalyzes the reversible phosphorylation of UMP to UDP.", "AFDB_id": "AF-A0LV52-F1-model_v4" }, { "swissprot_id": "Q08559", "sequence": "MRLLHHGEYGTKLIGGKCSIDGKLGHPCPLSRRRKKHLREKEMGPQYVRMYGPKRKAIIRTGNPDDGINLPDTGRGTLTAATIWSRAYHSNYSYLVRPKVVTLSKHRELMTTFLLYVLYVCIYISAFIK", "function": "Involved in K1 killer toxin resistance.", "AFDB_id": "AF-Q08559-F1-model_v4" }, { "swissprot_id": "Q6BS08", "sequence": "MSTTSIESNNDIGRSVKTIGVYSIGPEIGKGSFATVYKCFNTKTNESVAIKSVVRSKLKSKKLVENLEIEISILKTMKHPHIVGLLDYKQTTSHFHLVMDYCSMGDLSYFIRKRNQLIKTHPVISSLLERYPSPEGSHGLNEVLVIHFLKQLVSALEFLRNKSLVHRDIKPQNLLLCPPLHSKQEFKDGGFVGLWELPLLKIADFGFARFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPFRADNHVQLLKNIEKSNDRIKFPSAAQVPESLKRLIRSLLKYNPTERVSFNEFFNDPLIVNDLEGNDEPLETSEMDENLFISEYISPIKSSQKSQYIEPITTEVAVKEKSKQDLPAREVSTHASESQTKAVDTRPSSRDEEIKEIINKNSPGPETSRSIQPHNLKEKSLVLKNKDNDIILERDYVVVEKRAVEVNAIADELAHAGSGAVAINPRRTSSGSDNSYNGPNNMQLYRRPSLRSNSSGSQRRPSFTDRRISISISPTNALTKAIGLASNRLFGVNASGSPTNRLIEETDERLAINENNSSMNATNNTFSTILSNPNFANNLLIQKLNLPTSATVANNSQTNTSPQLSPQSKTDESVLNRLESLATKAHAINLFADVKFSQLIPSPPSSDALDDDLLHQNDMLPPKIVKSISEEGVVLYVKTLSLLAKGMVIASDWWYSQFEIDDPSNKNSNENPLKQSSNNNSDDLSLAVRINELVQWIREKFNECLEKAEFIRLTLQEANTLLSNEDSSEYMGNSNSVADKTRVVAEKLIFDRALEMSRNAAVNELVKEDLKGCELAYSTAIWMLEALLDEDSSNDEDRLDDEDKAMVEKFIVSIGNRLSVLKRKLEVV", "function": "Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.", "AFDB_id": "AF-Q6BS08-F1-model_v4" }, { "swissprot_id": "P16966", "sequence": "MNHAQLRRVTAESFAHYRHGLAQLLFETVHGGASVGFMADLDMQQAYAWCDGLKADIAAGSLLLWVVAEDDNVLASAQLSLCQKPNGLNRAEVQKLMVLPSARGRGLGRQLMDEVEQVAVKHKRGLLHLDTEAGSVAEAFYSALAYTRVGELPGYCATPDGRLHPTAIYFKTLGQPT", "function": "Renders tabtoxin-producing pathogens tolerant to their own phytotoxins.", "AFDB_id": "AF-P16966-F1-model_v4" }, { "swissprot_id": "P43565", "sequence": "MFNRSNTAGGSQAMKEGLGINKLSPISSNSNPSSLTSSNYEKYLQLATEKNPCMILELELDGKVRYGSPQWNTITGVADDSGSSPTYIADLILGSDQDKGVFQKATDMLLMNDDTSCTITFKIKAADYEGSAGCDDESTITTLEARGILIRDGHTQLPSHTMWIVKPRTNDWSDFYANEDAQDDMVIQLSDNCDDIDIQLPEEFAKTLGFGAKIFVQYLKRIRLEMIIDEFNLPLPKMELCRVCENFVPVWWLETHSQSCVCEHRTESLIQLLHDNLLEQQAILANFTKDSEYKGSQIQVRSNNFLNQVLDSLRELCQDAIDINPSEMVPDLYHSLSTFPQDNGNNNNNNNNNNNNNNALLDQFPIQKDTVSLNSYFQFSPRTNHNIQNVTSWQSRFFLNDDQDPGLALLIHDTLDLARKKVDAVLRLDNAMTYSLKIKNEVNNYVVQLIREQIEINKHAILTHPMNLRSSSIFHSPLPQIHSQQPEAENLIYSSSTPLQVQHDQCASFEAPSKSHLEPIPFPVSSIEETPTANDIRHPSPLPRSCSNTVMKLPTPRRKLDSNGLFSDAYLNADIIPNPSIESTISIDRDNNTNSRGSSMKQYGIGEATDSRTSNSERPSSSSSRLGIRSRSITPRQKIEYSHVDNDDRTNEMLSRDKDSLQPQPSVDTTITSSTQATTTGTKTNSNNSTNSVLPKLMTSISLTPRRGSPSFGNLASHSMQQTNSFKLIHDKSPISSPFTFSKDFLTPEQHPSNIARTDSINNAMLTSPNMPLSPLLLATNQTVKSPTPSIKDYDILKPISKGAYGSVYLARKKLTGDYFAIKVLRKSDMIAKNQVTNVKSERAIMMVQSDKPYVARLFASFQNKDNLFLVMEYLPGGDLATLIKMMGYLPDQWAKQYLTEIVVGVNDMHQNGIIHHDLKPENLLIDNAGHVKLTDFGLSRAGLIRRHKFVPHKSSLSISSTLPIDNPANNFTMNNNNSNHSQLSTPDSFTSDHKQYNRSKKSSLGQQYEHSEYSSTSNSHSMTPTPSTNTVVYPSYYRGKDRSHGSSNIDLPASLRRSESQLSFSLLDISRSSTPPLANPTNSNANNIMRRKSLTENKSFSNDLLSSDAIAATNTNINSNNNISLSPAPSDLALFYPDDSKQNKKFFGTPDYLAPETIEGKGEDNKQCDWWSVGCIFFELLLGYPPFHAETPDAVFKKILSGVIQWPEFKNEEEEREFLTPEAKDLIEKLLVVDPAKRLGAKGIQEIKDHPYFKNVDWDHVYDEEASFVPTIDNPEDTDYFDLRGAELQDFGDDIENDNANILFGKHGINTDVSELSAANLSPPLNHKNILSRKLSMSNTTNRSSNNSNSSVHDFGAHTPVNKLSIASVLESVPQETGYITPNGTGTTTTSAKNSPNLKNLSLAIPPHMRDRRSSKLNDSQTEFGSFNFRNLSALDKANKDAINRLKSEHFSEQPGVHRRTSSASLMGSSSDGSVSTPGSNASNTTSGGKLKIHKPTISGSPSTFGTFPKTFLRSDSFSTRSYSPERSISIDSSTLSRKGSIIGDNQQTTANSSDSPTMTKFKSPLSPANTTTVSSYFSRQRVLSKSFSQRTNSSDLSAEESDRLQAISRVNSLRNRRRSGRKSSSTSEIGYHMDVLVCEPIPIHRYRVTKDLENLGCTVVSVGAGDELVSRATSGVSFDLIMTALKLPKLGAIDIVQLLKQTNGANSTTPIVAITNYFQEAATSRVFDDVLEKPVKLDELKKLVAKYALKKSQEDEEHTILSDSDETH", "function": "Protein kinase that positively regulates proper entry into stationary phase of cells under nutrient starvation conditions. Involved in glycogen and trehalose accumulation, derepression of stress-induced genes, induction of thermotolerance and starvation resistance, and proper G1 cell cycle arrest. Also involved in the activation of a meiotic genes activation pathway. Phosphorylates IGO1 and IGO2, both involved in the TORC1 control of gene expression and chronological life span.", "AFDB_id": "AF-P43565-F1-model_v4" }, { "swissprot_id": "O67757", "sequence": "MSEQQVQELEKKWYALQVEPGKENEAKENLLKVLELEGLKDLVDEVIVPAEEKVVIRAQGKEKYRLSLKGNARDISVLGKKGVTTFRIENGEVKVVESVEGDTCVNAPPISKPGQKITCKENKTEAKIVLDNKIFPGYILIKAHMNDKLLMAIEKTPHVFRPVMVGGKPVPLKEEEVQNILNQIKRGVKPSKVEFEKGDQVRVIEGPFMNFTGTVEEVHPEKRKLTVMISIFGRMTPVELDFDQVEKI", "function": "Participates in transcription elongation, termination and antitermination.", "AFDB_id": "AF-O67757-F1-model_v4" }, { "swissprot_id": "Q05357", "sequence": "MSAPRRAVVTGLGVVAPHGIGAETFWKTAVDGTSSLARIDREGCGHLPLKIAGQVPDFDPAALIEDTYLVQTDRFTHFAMAATQLALDDARLSRADIDSPYSVGVVTAAGSGGGEFGQRELQKLWGQGSKYVGPYQSIAWFYAASTGQISIRGGFKGPCGVVAADEAGGLDALAHAALAVRRGTATVVAGATEAPLAPYSMVCQLGYPELSRSADPGRAYRPFTSAACGFVPAEGGAMFVLEEEGAARERGADARATVAGHAATFTGASRWEESRAGLAHAIGTALARAGCRPQDVDVVFADALGVPEADRAEALALADALGPHARRVPVTAPKAGIGRAFCAAAVLDVATALLAMEHELIPPTPHVLDVCHDLDLVVGRARPARPRTALVLSRGLMGNNSALVLRRGAAPFPE", "function": "Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptomyces halstedii.", "AFDB_id": "AF-Q05357-F1-model_v4" }, { "swissprot_id": "G5CTG4", "sequence": "MAHNEKDPSSVEPIKRKRFSNEYVRLFLAEFLGTFILIVFGCGTVAVTILSKHQSQDFFSVNVGFFLGIAFGVFIAGGVSGGHLNPAVTLAFAVINKCKWRKVPVYMAAQYLGAWVGSAILTAIYYDALHNHDQGNRTIETAGIYASYPQEFLTWQGGLADQIFATLLLMMGILALTDERNMVGPTGRAYVPLLVGLLVLAIGLAFGFNCGYPINPARDFGPRLFTAMAGWGTQVFSEPRGTYNWWWIPIIGPHVGAIIGALAYNFFIGYHWPKERDDVQLQSPSSPIVIVKNDAYQPLRPSRSVYSEELRITTS", "function": "Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.", "AFDB_id": "AF-G5CTG4-F1-model_v4" }, { "swissprot_id": "P43254", "sequence": "MEEISTDPVVPAVKPDPRTSSVGEGANRHENDDGGSGGSEIGAPDLDKDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRNKSDCPCCSQHLTNNQLYPNFLLDKLLKKTSARHVSKTASPLDQFREALQRGCDVSIKEVDNLLTLLAERKRKMEQEEAERNMQILLDFLHCLRKQKVDELNEVQTDLQYIKEDINAVERHRIDLYRARDRYSVKLRMLGDDPSTRNAWPHEKNQIGFNSNSLSIRGGNFVGNYQNKKVEGKAQGSSHGLPKKDALSGSDSQSLNQSTVSMARKKRIHAQFNDLQECYLQKRRQLADQPNSKQENDKSVVRREGYSNGLADFQSVLTTFTRYSRLRVIAEIRHGDIFHSANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNEPADMQCPIVEMSTRSKLSCLSWNKHEKNHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAWSVDFSRTEPSMLVSGSDDCKVKVWCTRQEASVINIDMKANICCVKYNPGSSNYIAVGSADHHIHYYDLRNISQPLHVFSGHKKAVSYVKFLSNNELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVYHKEITRPVTSHRFGSPDMDDAEEEAGSYFISAVCWKSDSPTMLTANSQGTIKVLVLAA", "function": "E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth). Represses CIP7 in darkness.", "AFDB_id": "AF-P43254-F1-model_v4" }, { "swissprot_id": "Q65ZA6", "sequence": "MSEIRLIRAINDELYLVEVQATLERKADSLHIGDLKIIKEKNSEKKKATLTVGNQYMEGVVESLKKPLAVLQKTNADPVDVYSSPSHELKCCSIIRERIRFSSRPLPTK", "function": "Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Replication factor C (RFC) complex has an essential but redundant activity in sister chromatid cohesion establishment. An RFC-like complex (ctf18-RFC) is formed where ctf18 replaces rfc1 in the RFC complex along with the association of dcc1 and ctf8. This complex is required for efficient establishment of chromosome cohesion during S-phase. Acts as a PCNA loader, loading PCNA onto primed templates.", "AFDB_id": "AF-Q65ZA6-F1-model_v4" }, { "swissprot_id": "Q2NK67", "sequence": "MMNMLSDRKKLILKAVVENYSQKRQPVGSKMLTYLPYLKFASATIRYDMVQLEKEGFLQKNHTSSGRVPSFKGYVYYLNHLLTRDHDVACMFESIDKVIQKKRFCKGQVIKEALNLLNNLTNYTTMAIGSDIFNNSKITKIDFIPLNSAQAVILIITDKGNVQHQNISLEQTKEISIYDLKDVVQVVNDLLKDKFLSEAAHIIQSDFFKKTIAKYICFQEQLIALFMEAFSSFASENLYFSGVSKMLEKPELNNPEIIKKFMGLLERKELLKIMLNQDSLSFKFSDGLQLTPLKDCMILSIPFDVNPNEKGRIAVVGPSWMKYPKVIPILEYLAVHLSKLNDQE", "function": "Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.", "AFDB_id": "AF-Q2NK67-F1-model_v4" }, { "swissprot_id": "F1RAX8", "sequence": "MLSLAKAKLAVVGIGRQCVAVRTLNGARAVHRSFSSSEHDQDSSTSENELFDIIISGGGMVGTAMACSLGLDPNLTGKKILLLEAGHEKKMDKIPETYSTRVSSISPGSATLLSGLGAWDHIVNMRCKPYNKMQVWDACSDALITFDKENLQDEMAYIVENDVIVAALTKQLQTLSDHVKVQYRTKVVKYTWPHPYHVSESIPWVQVALANGKTLHTKLLIGADGPNSMVRREAGIPTVKWNYDQSAVVAVLHLSEPTENNVAWQRFLPTGPIAMLPLSDTESSLVWSTSHQHAEELLQMDEESFVDAINSAFWSNENHSELVETAGSLFRMALSVLMPDSGSARQLPPSVSGIGPKSRVMFPLGMGHATEYIRHRVALIGDAAHRVHPLAGQGANLGFGDVSYLTQVLSQAAYNGKDIGAMQHLLEFETERQRHNLPMMTAIDLMKRLYSSNTAPMVLLRTFGLQATNAVPPLKEQIMAFASK", "function": "FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.", "AFDB_id": "AF-F1RAX8-F1-model_v4" }, { "swissprot_id": "O74384", "sequence": "MSYEKHSDAKASRYAWNQPWNPFEVTLSDPTYPMNLEEKNQIPYRFQSVPDDVPEVPHIESRYKNLPGNNIYLCCGRLQMSSQYKAFLISLFALILPGVLFFIFSAFWLWHHVSPAVPITFAYLYALAVVSMFKCSTADPGILPRNAYSLTYNPAHPWSVIPEDRKVLVGSTRSDSVFVNTVYCHTCHLYRPPRASHCHLCDNCVEYLDHHCIWLNTCIGRRNYRYYFIFLLSVVLSALYLTGLGFYTSIGSFHESTDTNFAAHLRRPWAGVSFFLGIYGALGAILPGILFCYQCYLISVGQNVHEYLRAKSTETEDVHPFHDSIWLNFLVVLCRPKNVSYVRPTRKSYV", "function": "The erf2-erf4 complex is a palmitoyltransferase with a major role in driving sexual development. Palmitoylates ras1. Palmitoylates isp3. Palmitoylates rho3.", "AFDB_id": "AF-O74384-F1-model_v4" }, { "swissprot_id": "P04956", "sequence": "MKKFLVLLIALIMIATLLVVPGVQTSAEGSYADLAEPDDDWLHVEGTNIVDKYGNKVWITGANWFGFNCRERMLLDSYHSDIIADIELVADKGINVVRMPIATDLLYAWSQGIYPPSTDTSYNNPALAGLNSYELFNFMLENFKRVGIKVILDVHSPETDNQGHNYPLWYNTTITEEIFKKAWVWVAERYKNDDTIIGFDLKNEPHTNTGTMKIKAQSAIWDDSNHPNNWKRVAEETALAILEVHPNVLIFVEGVEMYPKDGIWDDETFDTSPWTGNNDYYGNWWGGNLRGVKDYPINLGKYQSQLVYSPHDYGPIVYEQDWFKGDFITANDEQAKRILYEQCWRDNWAYIMEEGISPLLLGEWGGMTEGGHPLLDLNLKYLRCMRDFILENKYKLHHTFWCINIDSADTGGLFTRDEGTPFPGGRDLKWNDNKYDNYLYPVLWKTEDGKFIGLDHKIPLGRNGISISQLSNYTPSVTPSPSATPSPTTITAPPTDTVTYGDVNGDGRVNSSDVALLKRYLLGLVENINKEAADVNVSGTVNSTDLAIMKRYVLRSISELPYK", "function": "This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.", "AFDB_id": "AF-P04956-F1-model_v4" }, { "swissprot_id": "Q9HU15", "sequence": "MSRLPVIVGFGGYNAAGRSSFHHGFRRMVIESMDPQARQETLAGLAVMMKLVKAEGGRYLAEDGTPLSPEDIERRYAERIFASTLVRRIEPQYLDPDAVHWHKVLELSPAEGQALTFKASPKQLPEPLPANWSIAPAEDGEVLVSIHERCEFKVDSYRALTVKSAGQLPTGFEPGELYNSRFHPRGLQMSVVAATDAIRSTGIDWKTIVDNVQPDEIAVFSGSIMSQLDDNGFGGLMQSRLKGHRVSAKQLPLGFNSMPTDFINAYVLGSVGMTGSITGACATFLYNLQKGIDVITSGQARVVIVGNSEAPILPECIEGYSAMGALATEEGLRLIEGRDDVDFRRASRPFGENCGFTLAESSQYVVLMDDELALRLGADIHGAVTDVFINADGFKKSISAPGPGNYLTVAKAVASAVQIVGLDTVRHASFVHAHGSSTPANRVTESEILDRVASAFGIDGWPVTAVKAYVGHSLATASADQLISALGTFKYGILPGIKTIDKVADDVHQQRLSISNRDMRQDKPLEVCFINSKGFGGNNASGVVLSPRIAEKMLRKRHGQAAFAAYVEKREQTRAAARAYDQRALQGDLEIIYNFGQDLIDEHAIEVSAEQVTVPGFSQPLVYKKDARFSDMLD", "function": "Involved in the initiation of the fatty acid biosynthesis. Catalyzes the condensation of acetyl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protein (ACP) to make the fatty acid synthesis (FAS) primer beta-acetoacetyl-ACP. It can also use short-chain acyl-CoA as substrates, including butyryl-CoA, and hexanoyl-CoA, but does not use any of the longer chain acyl-CoA substrates.", "AFDB_id": "AF-Q9HU15-F1-model_v4" }, { "swissprot_id": "A3DLP6", "sequence": "MEIYGIVYSVKDPAGFGMAEYIIKYYGLEKSNVCKNAITCYVGNNFVLAGFSEDVIYFDFLDGRLPDKVSRYIVLSRHSSAKKVCSYTVHHTGNFGPEAPYGGRPRTLSIANPIVSHKLLINLSILAEEYGRIDEYEVSYEATHHGPTDVRKPLNFIEIGSTIDEWKDPVNHEIVALAVIKFLENPNHECIPVTGVGGGHYPRKHTKMAFEKNYCYGHIMAKYALQYLSPEILEEMIVKSDPVPQRIIVEKKGTRREHRRIIEQYVLNRGIVLEYI", "function": "D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.", "AFDB_id": "AF-A3DLP6-F1-model_v4" }, { "swissprot_id": "Q9VT90", "sequence": "METAKDNTARTFMELMRVPVQFYRTIGEDIYAHRSTNPLKSLLFKIYLYAGFINFNLLVIGELVFFYNSIQDFETIRLAIAVAPCIGFSLVADFKQAAMIRGKKTLIMLLDDLENMHPKTLAKQMEYKLPDFEKTMKRVINIFTFLCLAYTTTFSFYPAIKASVKFNFLGYDTFDRNFGFLIWFPFDATRNNLIYWIMYWDIAHGAYLAGIAFLCADLLLVVVITQICMHFNYISMRLEDHPCNSNEDKENIEFLIGIIRYHDKCLKLCEHVNDLYSFSLLLNFLMASMQICFIAFQVTESTVEVIIIYCIFLMTSMVQVFMVCYYGDTLIAASLKVGDAAYNQKWFQCSKSYCTMLKLLIMRSQKPASIRPPTFPPISLVTYMKVISMSYQFFALLRTTYSNN", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.", "AFDB_id": "AF-Q9VT90-F1-model_v4" }, { "swissprot_id": "P20482", "sequence": "MISNKKSYAMKMLQLALALSLLHYNPDYLLHRWDSQLELGTHGDGWELEMLRTVHRLDMDHNPYGNRKGLSPRIEDLLNFDDPSLGGMANGIGGCKLPPRFNGSTFVMNLHNTTGNSSVQTAALQDVQSTSAAATGGTMVVGTGGAPTSGGQTSGSALGEIHIDTASLDPGNANHSPLHPTSELDTFLTPHALQDQRSIWEQNLADLYDYNDLSLQTSPYANLPLKDGQPQPSNSSHLDLSLAALLHGFTGGSGAPLSTAALNDSTPHPRNLGSVTNNSAGRSDDGEESLYLGRLFGEDEDEDYEGELIGGVANACEVEGLTTDEPFGSNCFANEVEIGDDEEESEIAEVLYKQDVDLGFSLDQEAIINASYASGNSAATNVKSKPEDETKSSDPSISESSGFKDTDVNAENEASAASVDDIEKLKALEELQQDKDKNNENQLEDITNEWNGIPFTIDNETGEYIRLPLDELLNDVLKLSEFPLQDDLSNDPVASTSQAAAAFNENQAQRIVSETGEDLLSGEGISSKQNRNEAKNKDNDPEKADGDSFSVSDFEELQNSVGSPLFDLDEDAKKELDEMLQSAVPSYHHPHPHHGHPHAHPHSHHHASMHHAHAHHAAAAAAAHQRAVQQANYGGGVGVGVGVGVGVGSGTGSAFQRQPAAGGFHHGHHQGRMPRLNRSVSMERLQDFATYFSPIPSMVGGVSDMSPYPHHYPGYSYQASPSNGAPGTPGQHGQYGSGANATLQPPPPPPPPHHAAMLHHPNAALGDICPTGQPHYGHNLGSAVTSSMHLTNSSHEADGAAAAAAAYKVEHDLMYYGNTSSDINQTDGFINSIFTDEDLHLMDMNESFCRMVDNSTSNNSSVLGLPSSGHVSNGSGSSAQLGAGNPHGNQANGASGGVGSMSGSAVGAGATGMTADLLASGGAGAQGGADRLDASSDSAVSSMGSERVPSLSDGEWGEGSDSAQDYHQGKYGGPYDFSYNNNSRLSTATRQPPVAQKKHQLYGKRDPHKQTPSALPPTAPPAAATAVQSQSIKYEYDAGYASSGMASGGISEPGAMGPALSKDYHHHQPYGMGASGSAFSGDYTVRPSPRTSQDLVQLNHTYSLPQGSGSLPRPQARDKKPLVATKTASKGASAGNSSSVGGNSSNLEEEHLTRDEKRARSLNIPISVPDIINLPMDEFNERLSKYDLSENQLSLIRDIRRRGKNKVAAQNCRKRKLDQILTLEDEVNAVVKRKTQLNQDRDHLESERKRISNKFAMLHRHVFQYLRDPEGNPCSPADYSLQQAADGSVYLLPREKSEGNNTATAASNAVSSASGGSLNGHVPTQAPMHSHQSHGMQAQHVVGGMSQQQQQQSRLPPHLQQQHHLQSQQQQPGGQQQQQHRKE", "function": "Plays a role in posterior cephalic patterning. Probable subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis. Isoform B may have a repressive effect on Dfd response elements, thereby modifying the activity and specificity of the Hox system and moving the body anterior/posterior axis.", "AFDB_id": "AF-P20482-F1-model_v4" }, { "swissprot_id": "P33314", "sequence": "MSSNNEPAQSRTSYFKLNEFLSNVKHYKNTFKGEIQWCNNLSLNDWKTHYLQITSTGALTHSIDELTADSTNIQPIIKHLQQCRIEIIKDKHSSFKDINANCNFIIQVNTSGKDNKVYLRVKSWSDFKKLLTCLIWWSSMKTNGIFNKFQVSRPLEFKSKKMAKPESLLVYKLNVFGPIVKNIVLPPATNILESPDIINNDDNSVGWFSAMGVLKSNGMLDLLLQSDGSLIYSLNISQLLRSEIRILDSSVLQSENSLFLGELPLLRSQLGLEKFRIENIASAATNSSDISQEIIVEFPLRIDLEDCFIALQSFARSEYLSITGSDKSNDMKISNSFKISILEANFQSINLNDKNNTPWSIFTDITAWGHTWARTSMVSNSSNPFWREEFQFNELLRLTNSYLEIKQLFHDLNNKKRLRLIGKIKITQEIINDTRYNKETRLPIMDVDNKNFQIGTICIKISSNLNFILPSTNFVKLEKLLMNANLSMVSNLIYKSSSSMENDNKLTQTSIIFLDIFQSLSRIEEWFHVLIDKELAKIDGTVSRINQKNLDSKHVFNSLFRGNSILTKSIEQYFFRVGNEYLSKALSAILKEIIESNKSCELDPARVKEKDEVKKRKIIADNYKRLYSWVTKIWKRLYATSNDLPIEIRNVLKIFRQKLEIICIDDTLQIILNGISGLLFLRFFCPVILNPKLFKYVSQNLNETARRNLTLISKVLLNLSTLTQFANKEPWLMKMNNFIDKRHNDLLDYIDKMTQKKLDFNSKILNLSSTISRPKLAIEQTMLDDLPQIPYLLDKNLRETEFVNLIVNFSQEDMTKMEKYNHMDNGGKGELIEEEGLLSGSSLNLSVDKKDLDSPIEVKPEIGELEFEKITENNTEIFGDDLMNLLKSDDVGSRSRDLDNGANSGIKFNSIIPKAEEEKHAMKELEQESCLLYNRINHIRKRLSGYECASSTLFEDKKYSISLSHKIFYEEIKEGKEIVLKLLNKPTNENSSARLQKFFTKGVSSKSNNTVGDSYCKFLTIDVSDENPKSSNKTSVHGTSSENGAKDDYLTLPNSQGKGNLGNRFSPTKLSRIMRKPPNADVPKEQNSRKLTRWFKKKKETGGS", "function": "Stimulates the GTPase activity of BUD1/RSR1. Participates in the regulation of bud-site selection.", "AFDB_id": "AF-P33314-F1-model_v4" }, { "swissprot_id": "B9WEX6", "sequence": "MFSRLVLLRKVSISLGRYYSSQAHPQTYIYNLLSKSKCRSCGIQLQDKYPDKPGFYRLPGQNDNNTDNKSKTSELNKKYEKILQNLDVSDRNLLINNFSAPKQEHEKITSVPSLQQVTPVEEDACDTLEVQKTQQGQSLSCKRCNDVIYNSKNKSVYDPKRDNLNKSEFPIPKLQQVLSTIPIDAPLVYVFSANDFPMGINQEIFQYRPPQQIFFVMTKSDILIPKTNVAFYNNFKKFLQNYMFKRFNVPRENVFIASGKDRWKMNDLYHFIPNYAYIIGDTNCGKSTLVKSLLINHHVKHWKYEARQQRQNERPNGKQSSSASLKNKDFKQLDRLIDSFSSKNGPGTSHIPGFTRDVVPVDIDGIKQLFDVPGFTTNENMQDIFDKLNHKQIARITKGTSTFKYGSLKSKFDTIKNGQVLSLNGVGYLQFPGQDSMYQIRNVTRFALHKFKNLEKVDSILQRNEIPTSMSSHFIVNRQQQQQQRNEIRGYYKRYIVPPFYGTIDLVIKDIGYINIKPTGKKLTNELMVLYLHPSLEAIIRQPILNYIDPPSPKKLIDGTKMKSFITSDIGKTPFYSRLIPSKIPSDPSSFLASSPSSDYNQLNQYLQIDESSESAYNDILELDETNKYDYWIE", "function": "May be involved in the mitochondrial lipid metabolism.", "AFDB_id": "AF-B9WEX6-F1-model_v4" }, { "swissprot_id": "B2MW54", "sequence": "MAESTTTCFLLLVTGYVTAVMSEEAHLRSRRDFGCGQGMIFMCQRRCMRLYPGSTGFCRGFRCMCDTHIPLRPPFMVG", "function": "Has antibacterial activity against the Gram-positive bacteria S.aureus ATCC2592 (MIC=0.8 ug/ml), S.aureus 6A (MIC=0.8 ug/ml) and S.aureus 15A (MIC=1.6 ug/ml), and against the Gram-negative bacteria E.coli ATCC 25922 (MIC=3.2 ug/ml), E.coli 23A (MIC=6.4 ug/ml), E.coli 27A (MIC=6.4 ug/ml), P.aeruginosa 3A (MIC=3.2 ug/ml), P.aeruginosa 7A (MIC=0.8 ug/ml) and H.pylori NCTC11637 (MIC=6.4 ug/ml). Has antifungal activity against C.albidus ATCC2002 (MIC=25.6 ug/ml). Very low hemolytic activity against rabbit erythrocytes.", "AFDB_id": "AF-B2MW54-F1-model_v4" }, { "swissprot_id": "Q28FQ5", "sequence": "MEKEDAGAVQCGTGEGEAVVLNERSEQCSAFASIAGCDEAVAQCFLAENDWDMERAINSFFEPGVESALQNKAAADIADPLKQETMSGTASDSCIDLTGDDLVVTKSEATTSNSSTVKQEDESHFSFLTWNIDGLDESNVAERARGVCSYLALYSPDVVFLQEVIPPYYEYLKKRAVSYTIITGNEDEYFTAMMLKKSRVKLISQEIVPYPSTVMMRNLLVANVNISGNSICLMTSHLESTKDHSKERLKQLDIVLKKMMDAPPLATVIFGGDTNLRDQEVAKIGGMPNNILDVWDFLGKPEHCRYTWDTKVNKNLRAPYICRLRFDRIFFRASQEGSQVIPQSLYLAGTEKLDCGRFPSDHWGLLCDFAIIL", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals.", "AFDB_id": "AF-Q28FQ5-F1-model_v4" }, { "swissprot_id": "Q8ITW8", "sequence": "MTAEGRYLEIRKKTVKSKFRFPASSSSTRCLICSAQATGFHFEAQSCSACAAFFRRTVALTKSFKCITGRDDCNVHYSMHQICRSCRHKKCLSNGMKPGGVQPKKPNIETGRAFFTKSGLKRNKKFANVSPQTADEQKLVVEGVKVPKIEVQEPNSLEDLEQDNEFVIKTPTPRKISSSTSFSASTTTNYSTPGPSPMAPCSAGPDVLTLFIREEMKLGERRRLLFSERAVGTLLGQNKHCPYKKEDIKPLVFHDFRLTIKTHIMLVYEWLQTWPELQELDDFDRMSLLRKAVLIHFLLDPSFLSYQIGEPDKLIMQNGGFISTADHHGVGWEDETDISGENKRKYYVPIMKQITDEIMPAMEAMKITFEEFVALKALACFQGGFENVSEAKRHLITQQVNRIMTSLHTHYLENSEEKIAERFGTIVLMLSNIFTAGNDFVQNHREIDIFHIWDLDKLVLQLLNLDKIMETEARETAEKRAMRNGINVVNNNNDVLLGQAKLEK", "function": "Transcription factor. Binds to regulatory elements and regulates transcription of target genes, including acyltransferase dgat-2. As part of a lysosome-to-nucleus retrograde lipid signaling pathway, acts as a direct nuclear receptor of oleoylethanolamide (OEA) and, acting in concert with nuclear hormone receptor nhr-49, activates the transcription of genes promoting longevity and mitochondrial beta-oxidation. Required to modulate expression of delta-9 fatty acid desaturases, thereby regulating lipid metabolism; in some contexts, acting in concert with nhr-49. Involved in modulation of lipid metabolism in response to the citrate-induced mitochondrial unfolded protein response (mtUPR), acting downstream of transcription factor dve-1 and ubiquitin-like protein 5. Plays a role in modulating mitochondrial morphology and function. Involved in positively modulating life-span in a germline-dependent manner, acting in concert with nuclear hormone receptor daf-12. Plays a role in transgenerational lipid accumulation in response to a high-fat diet.", "AFDB_id": "AF-Q8ITW8-F1-model_v4" }, { "swissprot_id": "P40459", "sequence": "MKIFHTVEEVVQWRTQELRETRFRETIGFVPTMGCLHSGHASLISQSVKENTYTVVSIFVNPSQFAPTEDLDNYPRTLPDDIKLLESLKVDVLFAPNAHVMYPQGIPLDIEEQKGPFVSVLGLSEKLEGKTRPNFFRGVATVVTKLFNIVMADVAYFGQKDIQQFIVLQCMVDELFVNTRLQMMPIVRNNNGLALSSRNKYLCPESLKISENLYRGLKAAENAIRRLAPGGRLSRSEIIDTVTQIWAPYVDSHDFKIDYVSLADFKTLDELSDVENTSEQQPIVISCAVYVTDREKPDTVVRLIDNIVI", "function": "Required for pantothenic acid biosynthesis.", "AFDB_id": "AF-P40459-F1-model_v4" }, { "swissprot_id": "Q9FT72", "sequence": "MKKSPLPVQNVQSSDKNVAGKEALVKLLRWHFGHADFRGKQLEAIQAVVSGRDCFCLMPTGGGKSICYQIPALAKPGIVLVVSPLIALMENQVMALKEKGIAAEYLSSTQATHVKNKIHEDLDSGKPSVRLLYVTPELIATKGFMLKLRKLHSRGLLNLIAIDEAHCISSWGHDFRPSYRQLSTLRDSLADVPVLALTATAAPKVQKDVIDSLNLRNPLVLKSSFNRPNIFYEVRYKDLLDNAYTDLGNLLKSCGNICAIIYCLERTTCDDLSVHLSSIGISSAAYHAGLNSKMRSTVLDDWLSSKKQIIVATVAFGMGIDKKDVRMVCHFNIPKSMESFYQESGRAGRDQLPSRSVLYYGVDDRKKMEYLLRNSENKKSSSSKKPTSDFEQIVTYCEGSGCRRKKILESFGEEFPVQQCKKTCDACKHPNQVAHCLEELMTTASRRHNSSRIFITSSNNKTNEGQYSEFWNRNEDGSNSNEEISDSDDATEAANSVTGPKLSKKLGLDEKLVLLEQAEEKYYERNKQVKKSEKNAISEALRDSSKQRLLDALTRVLQLLACVEEIDSQKGSEFLENECYRKYSKAGKSFYYSQIASTVRWLGTASRDELMTRLSSVVSLAREQEPLEEPLLATEPVENIEEEDDGKTNTVESRVDEPTQELVVSPILSPIRLPQVPSFSEFVNRRKIKQNTLIDKSSEGFDDKKPAKIMKLQ", "function": "3'-5' DNA helicase that may play a role in the repair of DNA. Exhibits an ATP or dATP-dependent DNA-helicase activity. Cannot use GTP/dGTP, CTP/dCTP or UTP/dUTP as nucleotide cofactors. Catalyzes DNA strand annealing. On nicked Holliday junctions, unwinds the lagging strand. Cannot act on intact Holliday junctions.", "AFDB_id": "AF-Q9FT72-F1-model_v4" }, { "swissprot_id": "Q29AK2", "sequence": "MGLPPLQTQPGTFLVALGLCCWLLATANAHNCQHQHPKAHEVVHGVRIQLADSDDDDAAGSSDAAVHSVRRRSVTAEQPLRILLVYDDSVYRLEEEKFNLINDTVLPEAVQFWEQALMVRETKGIIRLNRKCDSTQVYVKNGHTHCIDQCKATTMCGEVQVPNEHLDVCRVCNATGQNCRIDSNTQPGDGIQNADFVFYVSARQTQRCFKGLTVAYAAHCQQEAALDRPIAGHANLCPESISTKPQELQTLISTVKHEILHALGFSVSLYAFFRDDEGRPRTPRKSETGKPFLNEKLQIHQWSNETIRKVVRENWSVRGGHVNKEVDMMVTPRVVAEARAHFDCDKLEGAELEDQGGEGTALTHWEKRILENEAMTGTHTQSPVFSRITLALMEDSGWYRANYSMATPLSWGKGLGCSFAMRSCKDWIQMNHARGRSIHPFCSKVKQDPLQTECTDDRNSVALCNLIRHDYELPKSYQNFDSLQNVKSGEEGFYGGSVSLADHCPYIQEFTWRSKNIIVRGSHCRFVENNPKPEKNFALESYGHGSKCFDHSEAMWEERSCHQTREWQHWGSGCYKYTCFDGRLHILVGNYTYKCSFPGQKLSIRIAANGWLHKGAIMCPPCHELCGSHFAAQGKQCRPGEEADPLNKYPRDNLACGAESRQQRSVAIISAALLLAAGLRLGHS", "function": "Essential for the coordination of mitotic progression, and also plays a role in cell migration.", "AFDB_id": "AF-Q29AK2-F1-model_v4" }, { "swissprot_id": "Q9C5W7", "sequence": "MACRGCLECLLKLLNFLLAVAGLGMIGYGIYLFVEYKRVTDNSVTFDLTNGDQSYVSFGRPILMAVSLSSNIFDNLPKAWFIYLFIGIGVALFVISCCGCVGTCSRSVCCLSCYSLLLILLILVELGFAAFIFFDNSWRDELPSDRTGNFDTIYNFLRENWKIVRWVALGAVVFEALLFLLALMVRAANTPAEYDSDDEYLAPRQQIRQPFINRQAAPVTGVPVAPTLDQRPSRSDPWSARMREKYGLDTSEFTYNPSESHRFQQMPAQPNEEKGRCTIM", "function": "Necessary for the efficient intracellular multiplication of tobamoviruses, being a component of the replication complex.", "AFDB_id": "AF-Q9C5W7-F1-model_v4" }, { "swissprot_id": "Q74MZ4", "sequence": "MASKVIRKFIQNAKLTVFSQEFIRLYLRGANVSKVIIRQTPIVNRVIIYSARPKMISEERKAHLAKLLELKFGLEKPVIEVLPIENPNLDAHVIAERLAMGIERNIRAYRRLAQRYLETIMNAGAIGAEIVIAGRLSGQRGKTWRFKAGNLRKTGTIGQFELDRAFNIAYLKPGVAGIHVTILKPDAEIPDIIEFKSPEEISIEEIEKIDKEIAEKMKKYLETYLLAKQM", "function": "Binds the lower part of the 30S subunit head.", "AFDB_id": "AF-Q74MZ4-F1-model_v4" }, { "swissprot_id": "Q00619", "sequence": "MRQPWWKDFTIPDASAIIHQNITIVSIVGEIEVPVSTIDAYERDRLLTGMTLSAQLALGVLTILMVCLLSSSEKRKHPVFVFNSASIVAMCLRAILNIVTICSNSYSILVNYGFILNMVHMYVHVFNILILLLAPVIIFTAEMSMMIQVRIICAHDRKTQRIMTVISACLTVLVLAFWITNMCQQIQYLLWLTPLSSKTIVGYSWPYFIAKILFAFSIIFHSGVFSYKLFRAILIRKKIGQFPFGPMQCILVISCQCLIVPATFTIIDSFIHTYDGFSSMTQCLLIISLPLSSLWASSTALKLQSMKTSSAQGETTEVSIRVDRTFDIKHTPSDDYSISDESETKKWT", "function": "Receptor for the peptide pheromone P-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; P-factor signaling alone may be sufficient.", "AFDB_id": "AF-Q00619-F1-model_v4" }, { "swissprot_id": "D1ZBF6", "sequence": "MANSDEIHYDLVEDDEFDIVNIVVEGLDETSIHSPPPSVSAATHGGVKNPSFSQRRTSGRHDFQKWLHEELGKYPAKTHAQKVVEELDAPKSGLIYLRGFNEPLYPYSDQGPPFRQQRHFFYLSGADFPGCAVTYDIPRQHLIVWIRRNDPRLSLWYGTTPSIEEVKSKSDVSDVRYIDDVTKYLHANLTPDTTLFLLHPDQTPKLEPPSLNLRHRFKGPKIDTTSLLPAIEAARVIKTPHEISLIRRAVALTSLAHRMVLQRIKHLSNEREAHAVFEGFCISQGAPRQSYAVIAASGANASTLHYEANDQPLEGKQTMLLDAGCEWGCYASDVTRTFPLKGKWTKEGEEIYKVVERMQRETIDAIRPGRLYYKLHLVACLVAVEELMKLGILHNGTRTEILAKGTVAAFFPHGLGHHVGLEVHDVSGRERLLLSSSSSSGLSRQAISGSRRLPPPRNMKREQVTPEDLAAMYREAMMDTAGDEVEQSAVAPPPPYRGRQRLKENMVVTVEPGIYFHRPYIQSFFLSNPDHAKYINTKVLDRYWDVGGVRIEDCILVTKDGYENLTTAPKGKEALKIINAGIPGFPCDGKA", "function": "Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.", "AFDB_id": "AF-D1ZBF6-F1-model_v4" }, { "swissprot_id": "B1MK49", "sequence": "MHPITYYPVDTQRLVRSNAERIRHKPYAHYFNPDVAVPEEVFAALKAPLEPEQVLGTSSTELNRLLEPGYLEGETGYCGLPDGAGYTSSLVRFPGATPEMFRWWFWWHSFEPERYSLWHPWCHADIWRTDPETETAPNLTDEQRYVGSTHHINEYIGQDPLDIEITFIDPARWGFDADGFAAAGIGAHACGSVLMKGSHMRLATMVHLARITDDGFELRSRYWIADRAEPRHDPVAGIAQLTTVPGFSGERQAYEQLVHDQTEFNHLATFLPDIYQEFGPR", "function": "Catalyzes the hydrolytic C-C cleavage of phloretin to phloroglucinol and 3-(4-hydroxyphenyl)propionic acid. Can also hydrolyze monoacetylphloroglucinol (MAPG) but not 2,4-diacetylphloroglucinol (DAPG).", "AFDB_id": "AF-B1MK49-F1-model_v4" }, { "swissprot_id": "P53901", "sequence": "MSEEVWNGNQGILSVYVSKARDLPNLNKLDKQNVMLRLRIAHMTRASNTLHRAGQNPVFHYLEKFDITPEIKPLMYVEVYCDRRKKSPLPIGRCEIDLLNAIRADPKEGYCTWYELKRSGDEFAGTIFIELTFTPKVPRLNRDDLNKEMDRLDSSMAMRPIPPLPTESEYDYVHGSTMRQITPQCVSTSHEDKDEGQPYRNGNVFSMSSKSDTAVLANSNDPIILPPTFSASMGTTSTLETNDTAISNTSNTKFHFANLRKLKEKINIFKNPDSSTNNCQNESNKVDIEALQKAIGVTSLSYDEDDDDDDENDAFYSSSHRVSHNYNQPPLPPIPTRDDMSNYSSSRNTPLVRRDRPSRLDSSSPNSHPHPSGLNSPKLPPLPTTSNSNFNSRKNSMSPTRKRPPPRLS", "function": "Required for the ingression of the plasma membrane into the bud neck at the end of cytokinesis, leading to the separation of the mother and daughter cells. Stimulates the synthesis of the primary septum (PS) by CHS2.", "AFDB_id": "AF-P53901-F1-model_v4" }, { "swissprot_id": "Q6R053", "sequence": "MNPNLLEKDLRGKETTNGSIRYKEANNFRSLPNSHTAACKTSLNNPSISRNHPHNKSASVLESEDEHGNERGENEKSLRMRGKSGINTKVCSRGHWRPTEDAKLKELVAQFGPQNWNLISNHLLGRSGKSCRLRWFNQLDPRINKRAFTEEEEFRLLAAHRAYGNKWALISRLFPGRTDNAVKNHWHVIMARRTRESQRQRQQPPPTLSRDAEMTVSSSCRYNQGKFINEEDDDDDVSAVSTCTTELSLTPPSSAYQPRFFNYDSTLASGKDGQCVQRAEVNGIYGKKMDHQNHHTISVSERKVEMKMRSGYYYFDFLGVGAS", "function": "Acts as a cell-specific local repressor of quiescent center (QC) self-renewal by cell divisions in the primary root. Counteracts brassinosteroid (BR)-mediated cell division in the QC cells. Regulates maternally seed size, especially before the heart stage, promoting both endothelial cells expansion and cell number in the outer integument layer of the seed coat. Modulates the expression of genes involved in cell wall metabolism such as cell division and expansion. Negative regulator of flowering via the repression of FT transcription.", "AFDB_id": "AF-Q6R053-F1-model_v4" }, { "swissprot_id": "A0R4Q6", "sequence": "MTQMLTRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVLA", "function": "Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.", "AFDB_id": "AF-A0R4Q6-F1-model_v4" }, { "swissprot_id": "P94417", "sequence": "MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAEDTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLEGDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVLPESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENFTDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKNTNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEHGLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGEAMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAGVLIS", "function": "Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.", "AFDB_id": "AF-P94417-F1-model_v4" }, { "swissprot_id": "Q941B6", "sequence": "MAQAARLSLRMQKELKLLLSDPPHGASFPHLSSAANGSGDFSTFSTIDAQIEGPEDTVYANGIFNLKIQIPERYPFQPPIVSFATPIYHPNIDNSGRICLDILNLPPKGAWQPSLNISTVLTSMRLLLSEPNPDDGLMCEVSREYKYNRQTFDYKAREMTEKYAKVKADGCSTSLQIKNHGDEKSGESGNSVKLKLTVESSLSIAHTVKRETAGRDEQEDGNGKRKAVVGFGEGNSFGNDGIKRSRKKLSLALPSQSQKKDLCGEEELTRGVSAACKENKKPNLNGKKLSLGLKQPCNDTLASFRTSAAKSDNNRLSRKLSLRSPLGELNEVSKPEVLAQTDMKLEMNQNEDARSLRGEFENSVLEETSMAESIVVLDSDDSGQEEEERVSSSRSRLSLAKRRVLKCRP", "function": "Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.", "AFDB_id": "AF-Q941B6-F1-model_v4" }, { "swissprot_id": "P45157", "sequence": "MAETIPLNPITLPLNQISLIEASAGTGKTYTIGSLYLRLLLKAGENNFSRPLNVEEILVVTFTEMATEELKKKIRERITDAINKLTAFAKTQDKSAFKNDEFLTALCDNLNIFEAIHRLKLAEQNMDLAAIYTIHGFCRRMLMQYAFHSGIHFNLELIKDQSDLLVRFANEFWREHFYPLDFESANFIATELVSPANVLSLLKADLGKDLQVEIENKQALSVPIQIFLPQYLGGYQKALNELKAFWLESADEISAIITNELVKDYPKDQLKSLNRKKYQVKRLGDWINKINQWSNNPRDYQINTTLKDYFLQSSIEKNCEESTDKNKDKKPATPFYSPIFADLEKRVNALMTPDLLSKLTLYHYRQGLQQKLLDYKLNHQEKSFDDLLRLLCEALQDAQGDELAEMIRFQYPFAMIDEFQDTDSQQYAIFSKIYRDNPEKNTGFIMIGDPKQAIYRFRGADIFTYLKASDEAQSRFELTKNYRSEKHLVDGVNALFDFPQSPFIYQNIKFTAVDSRDDHLRFYLNGKVEPAYRFYLTESDKVNKTEMAKICAISIQHWLKSAAENQAVFQNEDTYKTLQAANIAVLVRDKNEAALVKNELQKLGIASVYLSDQNSVFDSNVAKELAWVLKACLNVAERPILNAIATALFGLNAADIHQIQQNEADWQRWADSFAQYQQTWQRQGILAMLHQILLEQGISERLLSQATGERDLTDFLHLAEILQQAATLHESEAALLSWFEKQIQGEARQEAQIRLESERQLVKIVTIHKSKGLEYDLVWLPFLAAPSKDPSKKYINIYYSKERDETLWDIENRNLNALCEETFAEELRLLYVALTRAKYQMAFALPAQFDKKWNALHYVLSQGEIGKEINLSDSKDTETLLQTFKEKMQDNVEICTKPNLEALPTLSINTKNDDFKASEFTGNIEQDWRITSFTSIEQAHRRQNYFTESAGKKHAVFDDAKDYDSQNAIEISTALLNENESNILDLPRGKQVGTALHRHFENCYFSDLANTEEIDKLRQSLQLDETFTESLQNWLQQISHTPLSNEIGIALADLANKDCIKEMPFYLAIREHFDVEAFNHTLKAHHHLPSESLQFEQIQGMVRGSIDLVFRHNGKYYLVDYKSNFLGSTLADYNQEALKKEMLHSHYDWQYLIYTLALHRYLQSVVPHYDYARDFGGVFYLFLRGMNGEPQSGVFYDRPSVELITELDGVF", "function": "A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.", "AFDB_id": "AF-P45157-F1-model_v4" }, { "swissprot_id": "Q5R5M4", "sequence": "MELKKSPDGGWGWVIVFVSFFTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCLYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKKIAPEDLPDKYSIYNEKGKNLEENINILEKSYSSEEKCRTTLANGDWKQDSLLHKNPTVTHTKEPETYKKKVAEQTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYEIAFYFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAPTTFLYKVASNV", "function": "Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.", "AFDB_id": "AF-Q5R5M4-F1-model_v4" }, { "swissprot_id": "Q89FG2", "sequence": "MAGPRHISVSEASRPVLPRHAKLKYDETREVWVILAPERVLAPDEIAVEVLQLCNGERSVGDVSDQLAAKYAAPREAILTDVIAMLQDLADKGFLTEAREKTS", "function": "Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.", "AFDB_id": "AF-Q89FG2-F1-model_v4" }, { "swissprot_id": "Q0WNX9", "sequence": "MSERKRELAEEASSTSFSPLKKTKLNDSSDSSPDSHDVIVFAVSSSSVASSAALASDECSVTIGGEESDQSSSISSGCFTSESKEIAKNSSSFGVDLEDHQIETETETSTFITSNFRKETSPVSEGLGETTTEMESSSATKRKQPGVRKTPTAAEIEDLFSELESQDDKKKQFIEKYNFDIVNDEPLEGRYKWDRL", "function": "Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity. Regulates cell division which is crucial for plant growth, development and morphogenesis. May inhibit CDK kinases specifically involved in the G1/S phase transition.", "AFDB_id": "AF-Q0WNX9-F1-model_v4" }, { "swissprot_id": "Q5U623", "sequence": "MASPDRSKRKILKAKKTMPLSCRKQVEMLNKSRNVEALKTAIGSNVPSGNQSFSPSVITRTTEITKCSPSENGASSLDSNKNSISEKSKVFSQNCIKPVEEIVHSETKLEQVVCSYQKPSRTTESPSRVFTEEAKDSLNTSENDSEHQTNVTRSLFEHEGACSLKSSCCPPSVLSGVVQMPESTVTSTVGDKKTDQMVFHLETNSNSESHDKRQSDNILCSEDSGFVPVEKTPNLVNSVTSNNCADDILKTDECSRTSISNCESADSTWQSSLDTNNNSHYQKKRMFSENEENVKRMKTSEQINENICVSLERQTAFLEQVRHLIQQEIYSINYELFDKKLKELNQRIGKTECRNKHEGIADKLLAKIAKLQRRIKTVLLFQRNCLKPNMLSSNGASKVANSEAMILDKNLESVNSPIEKSSVNYEPSNPSEKGSKKINLSSDQNKSVSESNNDDVMLISVESPNLTTPITSNPTDTRKITSGNSSNSPNAEVMAVQKKLDSIIDLTKEGLSNCNTESPVSPLESHSKAASNSKETTPLAQNAVQVPESFEHLPPLPEPPAPLPELVDKTRDTLPPQKPELKVKRVFRPNGIALTWNITKINPKCAPVESYHLFLCHENSNNKLIWKKIGEIKALPLPMACTLSQFLASNRYYFTVQSKDIFGRYGPFCDIKSIPGFSENLT", "function": "Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).", "AFDB_id": "AF-Q5U623-F1-model_v4" }, { "swissprot_id": "P16699", "sequence": "MKVYKKVAFVMAFIMFFSVLPTISMSSEANGAALSNPNANQTTKNVYSWLANLPNKSNKRVVSGHFGGYSDSTLAWIKQCARELTGKMPGILSCDYKNWQTRLYVADQISYGCNQELINFWNQGGLVTISVHMPNPGFHSGENYKTILPTSQFQNLTNHRTTEGRRWKDMLDKMADGLDELQNNGVTVLFRPLHEMNGEWFWWGAEGYNQFDQTRANAYISAWRDMYQYFTHERKLNNLIWVYSPDVYRDHVTSYYPGANYVDIVALDSYHPDPHSLTDQYNRMIALDKPFAFAEIGPPESMAGSFDYSNYIQAIKQKYPRTVYFLAWNDKWSPHNNRGAWDLFNDSWVVNRGEIDYGQSNPATVLYDFENNTLSWSGCEFTDGGPWTSNEWSANGTQSLKADVVLGNNSYHLQKTVNRNLSSFKNLEIKVSHSSWGNVGSGMTARVFVKTGSAWRWNAGEFCQFAGKRTTALSIDLTKVSNLHDVREIGVEYKAPANSNGKTAIYLDHVTVR", "function": "Could be involved in the degradation of glucomannan and catalyzes the endo hydrolysis of beta-1,4-linked mannan, galactomannan and glucomannan.", "AFDB_id": "AF-P16699-F1-model_v4" }, { "swissprot_id": "Q80YT5", "sequence": "MSHHSSPPPKHKGEHKGHGLPRGSERGSSSRDKDRSATTVSSSAPMPAGGKSSRTNCPPPAPPKTVNRLINEKSPYLLQHAYNPVDWYPWGQEAFDKAKKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLNENFICVMVDREERPDVDKVYMTFVQATSSGGGWPMNVWLTPGLQPFVGGTYFPPEDGLTRVGFRTVLMRICDQWKLNKNTLLENSQRVTTALLARSEISVGDRQIPASAATMNSRCFQQLDEGYDEEYGGFAEAPKFPTPVILNFLFSYWLSHRLTQDGSRAQQMALHTLKMMANGGIQDHVGQGFHRYSTDRQWHIPHFEKMLYDQAQLSVVYTQAFQISGDEFYADVAKGILQYVTRTLSHRSGGFYSAEDADSPPERGMKPQEGAYYVWTVKEVQQLLPEPVVGASEPLTSGQLLMKHYGLSEVGNINSSQDPNGELHGQNVLMVRYSLELTAARYGLEVEAVRALLNTGLEKLFQARKHRPKAHLDNKMLAAWNGLMVSGFAVTGAALGMEKLVAQATSGAKFLKRHMFDVSSGRLKRTCYAGTGGTVEQSNPPCWGFLEDYAFVVRGLLDLYEASQESSWLEWALRLQDTQDKLFWDPRGGGYFCSEAELGADLPLRLKDDQDGAEPSANSVSAHNLLRLHSFTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRTLSAQQQTLKQIVICGDPQAKDTKALLQCVHSIYVPNKVLILADGDPSSFLSRQLPFLSSLRRVEDRATVYIFENQACSMPITDPCELRKLLHQ", "function": "May play a role in fertility regulation.", "AFDB_id": "AF-Q80YT5-F1-model_v4" }, { "swissprot_id": "Q7YXU4", "sequence": "MNLKPPTSKVELRIKCHKILDKDTLSKSDPRASVYEKDRAGQFRLIGKTETIQNQLNPEFKTPIVIDYRFEEIQVLKFEIHDVDKNDEDFIGDASCTLTSILSKPGQTVCLQLLTKSGKHAGSMTVIAEEIKNTLQTIKFNLIGKKFDKKDLFGAGCDPYLIISRKVPSTNTFVKIYESQVQKGTLNPVFSGIEMKLEELCGGDMQREIKFEFYDWDRIGKHDYIGEFHTNAQELLQPNQAFNVINSHKQEKKSGYKNSGTVSVSDAVIEREYNFLEYIMGGCQMNLIVGIDCTASNGDSNDPNSLHYKNAQGLNQYANAICSVGNVIVPYTTTPLIPVYGFGGIMPGQSEVSHCFPMTLNASNTLCCGVNGVLDCYYDNISKIQLHGPTYFAPLINMAARYASQGQSQSNQKYTILMIITDGEILDADNTIDAIVKSSGLPLSIIIVGVGNANFTNMNILDGDDAALQSGGVRAERDIVQFVAMRDYLNRPNELAAEVLREIPTQFLSFMKKYKFRPNPPPPPPPVIIGAPPQYDNPTTTTTATSPSTGIDLNKGSNVGLNLTKTESSPSPSGGAGIDLNKGSVVDITKGVSNVSLEKN", "function": "Required for cytokinesis, contractile vacuole function and development.", "AFDB_id": "AF-Q7YXU4-F1-model_v4" }, { "swissprot_id": "Q54C27", "sequence": "MKVLNNLLLFVFLIFLVGSNVVNSTSQTWINQDVQRSIDVTTHLSKESISIKAKSLTDKNDIYQISFNSKYHVSIQALDSQNNELKVYLSPNSINIKEGFKTYNIELKNKVKKDEIVQLKVKVTSMIEQMIPYPSEIKQGQTQLVLYLNNHYFTSPYKTETQKTTVKLASSKVESYSEEQPTSLKGMTVTYGPYSAIEAFSVSPMRIHYENGSPFFVLTNLLKEYEVSHWGNLAVETHYQLENKGAHLVGAFSRLDYQRNPSVNPNQIAEVNEAVPLSATDFYYRDSIGNISTSSYQYLANRINFKIQPRFPLMGGWKNTFYTGYNLPIEKFLSVDTLTGQYHLNVTFGVGIDNVYVENHILKVVLPEGATDIKVHAPFAFTQSEENRKTYLDTIGRPVVVINIKDTASENYRYIQVTYNLSSLSIFHEPLLVIGAVFTLCIFIILYSRFDLSISKSKQI", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.", "AFDB_id": "AF-Q54C27-F1-model_v4" }, { "swissprot_id": "P38537", "sequence": "MAKQNKGRKFFAASATAALVASAIVPVASAAQLNDFNKISGYAKEAVQSLVDAGVIQGDANGNFNPLKTISRAEAATIFTNALELEAEGDVNFKDVKADAWYYDAIAATVENGIFEGVSATEFAPNKQLTRSEAAKILVDAFELEGEGDLSEFADASTVKPWAKSYLEIAVANGVIKGSEANGKTNLNPNAPITRQDFAVVFSRTIENVDATPKVDKIEVVDAKTLNVTLSDGTKETVTLEKALEPNKETEVTFKIKDVEYKAKVTYVVTTATAVKSVSATNLKEVVVEFDGTVDKETAEDAANYALKSGKTIKSVSLAADNKTATVTLTDKLNNNKADAISISNVKAGDKEINVKNVEFTAVDNKIPEVTEVKSLGTKAVKVTLSEPVENLSSTNFTLDGKAYFGNVVMGAGNKTVILTPYSSSALSVGDHKLTVSGAKDFAGFVSLNSTHEFKVVEDKEAPTVTEATATLETVTLTFSEDIDMDTVKASNVYWKSGDSKKEASEFERIADNKYKFVFKGSEKTLPTGKVDVYVEDIKDYSDNKIAKDTKVTVTPEIDQTRPEVRKVTALDEKTIKVTFSKTVDGESAIKTGNYTVKDKDDKVVSVDKVTVDSKDSKSVIIDLYSKVSVGENTITIKNVKDATKLNNTMLDYTGKFTRSDKEGPDYEHVINADAKAKKVVLKFDKKMDAASLADYSNYLVKINDTLQTLSEDVATLSVSNDATVVTITFAETIKGDDVVFASGKAISGSGKVNVNELQVMGVKDTSGNVHKKFNGSENKITLSSTSTPLKLAKIDKDYDAKYTAELVDRKTVKVKFSTVINSAAANAFTSESHKIDSIQVNGTSTVTVKFKDEINTNASDLDLKVNLSKLVDIAGNESTNNTPIAIKAGINLLDSVAPVVVGEPVVDKETITFTFSENLTSVSIGEVLSTDFTVTRVSDNKDLAIKDYSVAIANNNQVVITLSDNREVATAYKVTAKNAKLITDDNGDKKNAIADFTKTTATKVEASGTLSLDAAKTNLNNEITKAKDAKATGTEGTAATNQIVGSKDALQVAIDVAELVKNDTAATLQQLTDAKTDLTAAITAYNAAKVEDISSLLVAPDLVLGTTDNGTITGFVAGTGETLKVTSDSAANVEVTDPTGLAVTAKAKGEANILVQVLKGDKVIKTGTVKVTVSE", "function": "The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of bacteria.", "AFDB_id": "AF-P38537-F1-model_v4" }, { "swissprot_id": "Q9VEG6", "sequence": "MSRILFILLLLIVTQLSELQAAAFSVRQNRFDEVPDLQTPAPLATSTESSKKPEKATSGLLKKCLPCSDGIRCVPQIQCPAHVRMESHEKPQICDLPAGKFGYCCETGQNHTAPKPETSPKERRSGFPTILSPAVLDEARRNFEHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAISNSAIEQVMTTQLFGKKEQVPVEDFITNNVPIKFTETPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSDGTPLLGARKISRTLLSDVDRPHPKYNLMVMQFGQVLAHDISQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFVRLSLVPSPDCQLSYGKQLTKVTHFVDASPVYGSSDEASRSLRAFRGGRLRMMNDFGRDLLPLTNDKKACPSEEAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQPMQQVDSSISQGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFPIEIAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPSVNLEAWRA", "function": "Required for ovarian follicle maturation. Involved in the formation of a rigid and insoluble egg chorion by catalyzing chorion protein cross-linking through dityrosine formation and phenol oxidase-catalyzed chorion melanization.", "AFDB_id": "AF-Q9VEG6-F1-model_v4" }, { "swissprot_id": "Q8VYR0", "sequence": "MWSVMGLVRRTAMSSTVNKASPVRSLLGGFRCLNVESKEEDEKKDMTVLEAKKLMRLVNVEDMKKKLIGMGDKEMVTYTTLIEASQGLGIARSLDEAHAFARVLDDAGVILIFRDKVYLHPHKVVDLIRKAVPLGLNPDDELIREEFDKMRSMKEEIDVLAHQQVRKILWGGLGYSVVQIGIFVRLTFWEFSWDVMEPITFFTTATGIIVGYAYFLMTSRDPTYQDFMKRLFLSRQRKLLKSHKFDAERFKELENKWKITSCSSSSCHANASIRNRVGVDLDLEDSLQSHHRD", "function": "Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.", "AFDB_id": "AF-Q8VYR0-F1-model_v4" }, { "swissprot_id": "B0R5L0", "sequence": "MTTFLAGGTGTPKLLAGARRVFDPAETTVVGNTGDDVALGGLLVCPDLDTVLFEGGGVLDRETWWGIADDGSTTHDYLTDLAAAADIDPDTPRYLPDDAQTAGRDIARWRRFSAASEFMFIGDRDRAVHTLRAGLLDEGHTLTEVTRRLADAFDLSVDLVPMSNDPVATIVQTPDGEQHFQTFWVAEHGDPTVEDVEFRGGERATAAQPAIEAIRDGPVVVGPSNPVTSIGPMLALDGIADALRDAQVVAVSPFVEDEVFSGPAAKLMAAVGHDPSTAGVADAYDFADAFVLDTADSTDLDRPVVRTDTSLDTEADAERVARACRDALVAASGEVT", "function": "Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.", "AFDB_id": "AF-B0R5L0-F1-model_v4" }, { "swissprot_id": "F4JRF5", "sequence": "MKRKSPLQVQALEGFYLEQMYPTPKEMEDLGKSLGLTLKEVRGWFKRRRSRGKGVKSMANDGLGAKNPQLYDRSLMRSSTSSRCVGVAVEERCIVGTRKASCQNLLPSSHILAKVFRKDGPSLGSEFDHLPSGARKASWLGTSSVGQQKQKVARKRKISELMDHTSQDCIQENATVMKHGIGKGLMTVWRVMNPNRRDVSPCVDLLDERATLPQSSARNPPHQKKKQRQLASILKQKLLQKRSTEKKRRSIHREAELNKDETQREFKENCELAADGEVFKETCQTISTLVDDEELEMRERHERGNPLTCSCHHPSSGSHGCFLCKGIAMRSSDSSLLFPDLLPKFPPNSVQMRMPFGLHPWNSSPESVKKLFKVVHFLYTYSVTLDIGPFTLDEFTRAFHDKDSLLLGKIHLSLLKLLLLDVETELERGSFSNLSISCKFLALLQSVESQILILDMWRNSLNSLTWTELLRQILVAAGYGSLKCAVQSEELSKERKLMKKYGLRLGTLKGELFRMLNGQGNNGLKISELADAPEVAVLNLATVPEERENSICSTLASDITLFEKISESTYRVRVNCFSEDPDKSQSDSDDSGSVDDESDDCSISSGDEIEHVSENPALRKVKCRKRRKHKSKMREVCSEIDESHPGEPWLLGLMEGEYSDLSVEEKLDVFVALIDLLSSGSTIRMEDLPRAVADCAPSIYSHGSGGKIKRSSSNQYSYPRGSWVHGGELYGIKALSKSSDSHPVDSSSIVGAFAKLAGNRANNVHPMQSVYLGSDRRFNRYWLFLGTCNANDPGHRCVFFESSEDGHWEVINNKEALRALLSVLDDRGRREARLIESLEKRESFLCQAMLSRQVTQSETAHFTDIVREDSSSPVSDIDNNLCLNEIANDQFSSQHAAIVFEIGSKREKSLLWSLIQEFDDWIWANFNFNLNSVKHRRRSYLDSLTRCKSCHDLYWRDEKHCKICHATFEVDIDLEERYAIHAATCMRKEECDTFPDHKVLSSQLQSLKAAVYAIESAMPEDALIGAWRKSAHRLWAKRLRRSSSVSEITQVIGDFVGAINEEWLWHCSDQGQTLMGEIINCFPSMPQTTSAIALWLVKLDTLIAPYVEKAPPERDQPLCRTRNTSRRASKR", "function": "Transcriptional regulator required for the maintenance of the plant vegetative phase. May prevent the early activation of the vegetative-to-reproductive transition by regulating key genes that contribute to flower timing.", "AFDB_id": "AF-F4JRF5-F1-model_v4" }, { "swissprot_id": "Q23255", "sequence": "MCGSDDSFDDFVPDSQEPASSRTRNQDHLDDDEVPCSQRPDAANDTMVEDLDEGDEPAHDESEDIIKILVATDIHCGYGENKANIHMDAVNTFEEVLQIATEQKVDMILLGGDLFHENNPSREVQHRVTQLLRQYCLNGNPIALEFLSDASVNFNQSVFGHVNYYDQNLNVGLPIFTIHGNHDDLSGKGLTALDLLHESGLVNLFGKHSNIQEFIVSPILLRKGETRLALYGIGSQRDDRLVRAFKNNSISFLRPNAGAEDWFNLFVLHQNRPRRAMHRSTGNFLPESLIPQFFDLLIWGHEHECKPDPQYVASSEAVGDGFYILQPGSTVATSLTPEEALQKNAFLIKIKGRKFASKPIPLQTVRPMVCDELLLDKIPPGSRPILKTDRPKHTDGRYIDEIAIEAKINEMITTAKAKRRPRQPELPLIRLKVIYDGDWLNITPANAKRIGLRYENVVANAVDMVFIKKNNKPKEGKLQTENEKNITEMADEMGQVSATNLQTIINDYFINQPLVDQMTVLKPIGIGRALEQYSAIEEGGLATSANRNFDSCLMHQIDVVRKTLKKMPLPPINDPSDLDKFRDLITKDLYDMKKADSERFKNPVADVEMEEDEDDPQYYMPPQSTSRTNYASGSEDEVANSDEEMGSSISRHSKQPTTRGRGRGARGAGASRETTRGRSNKVVSTRQIDSDGFEIINDSPSPPPASRSTRGKARGKSAPSKKRDLSFF", "function": "Required for meiotic crossing over and chiasma formation. Pachytene morphology and homolog pairing are normal. Vital in long term for maintenance of reproductive capacity of subsequent generations.", "AFDB_id": "AF-Q23255-F1-model_v4" }, { "swissprot_id": "A0A1J0HSQ1", "sequence": "MAQQKVIKYTVEHNRKDGVSEEDFIEWFTNTLIPQMVPVMQKNNILKYAVHKTDHQISTAFQSQVDKVRPGWVVSKCDLILEHWVNDLGDIMKLSQDPEWAAALKDQDVWMDNSKSNIHIGYDTIYIEDGTITNVPRK", "function": "Dehydratase; part of the gene cluster that mediates the biosynthesis of iso-A82775C, a enylepoxycyclohexane and biosynthetic precursor of the chloropestolide anticancer natural products. Within the cluster, the prenyltransferase iacE prenylates siccayne to generate pestalodiol E, using dimethylallyl diphosphate (DMAPP) as cosubstrate. The probable oxidoreductase iacF is then involved in the epoxidation of pestalodiol F to pestalodiol F, which is further converted to pestalofone A by the short-chain dehydrogenase/reductase iacG. Iso-A82775C is subsequently generated from pestalofone A by the short-chain dehydrogenase/reductase iacC. Iso-A82775C is further condensed with maldoxin via a Diels-Alder reaction to produce the anticancer natural products chloropestolides A to E (Probable).", "AFDB_id": "AF-A0A1J0HSQ1-F1-model_v4" }, { "swissprot_id": "P30820", "sequence": "MKVRAQVPTVKNATNFNMVADSKTAVGSTLENLKAAIAGETGAHAKYTAFAKAAREQGYEQIARLFEATAAAELIHIGLEYALVAEMEPGYEKPTVAAPSAYSCDLNLISGANGEIYETSDMYPAFIRKAQEEGNSKAVHVFTRAKLAESVHAERYLAAYNDIDAPDDDKFHLCPICGYIHKGEDFEKCPICFRPKDTFTAY", "function": "Exhibits NADH peroxidase activity (in vitro).", "AFDB_id": "AF-P30820-F1-model_v4" }, { "swissprot_id": "Q4UNB2", "sequence": "MIYMLDTNICVYAINKHPDSYYNNLELLAKNNTIAISSIVLAELQYGVSKSKKKEQNQSKLDIFLSRLEIIDFSAKCTFYYGELRTELEQKGLIIGNNDLLIASHAIAENATLVTNNIKEFKRIPNLILENWDK", "function": "Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its RNase activity is partially inhibited in vitro by VapB2.", "AFDB_id": "AF-Q4UNB2-F1-model_v4" }, { "swissprot_id": "P20950", "sequence": "MFTQAVIALIGLVSIRTGKTEDVTPCTTNCGCWARLEKQITVYRGDYSAAEENLKENKKNFGKIIAATVLGSEKLKATVAPVLLSAAQIIHECEEALTTARPAILDAEKKVAELRALYDVQQKLKEGNGELQLHIQDDTNINTAKEVPKANLGNINKKGCADDLNTPDAATIDKTNIETEGPTPKVITHVHVEARCQRDGTPTNGCHDGQLGQNGKLEFSLTYDSKDTNDLATWLADTATKKQISATEVDFIGNLNTEANTAIKGLKSSNPAPACSKKIRDYKTIADNSKFNLMVTKALIGKTDAEAGQESKEPELAAAITKYYGTEGTKFEDQLWKAIERTPAYLGDQKKEQTTKIEKLETLTEVGEATARGLVKQLAAGAQARQTASGDDQSAENQCGGKKEDECKDGCELVEGVCKPVKQGEGENKEKTGTTNTTGSNSFVIKKAPLWLAFLLF", "function": "VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.", "AFDB_id": "AF-P20950-F1-model_v4" }, { "swissprot_id": "A2CI35", "sequence": "MSSRRLGSSRARGRDLAHEVKHFGGLTKHLKKIIFDSNNCLTELKTSDHFEEEVISTLVLPPVADEIVGKVTKNPPALVIFGQTYTSKATLVNKIFREDLFQIVDDSDNNKTWRAVHLKYGSQRNTRLTLTNSFELLNEEPGSPVMRNSWTGIPRVEMLVKEEHQKDACMLSATTEATLNHPLLQCKLQILVTPHNCPGISISQAYNVCTHNVLPVLLYCFDKDQLSEENLRDLQELQNCAGTLPILFVDCREPSEPLVAHRERRLVEDAHEDFDDDSAYDTDERIEGERERHNGLDARLRRRCRPTPNDRPSVIDQLSRAGFISSPEENGRMRGVLDVFTIVNQVEDLHNSAAIVQFIRRSLQYYLIRCCTAMHDLHQHCMNLFITTAFDMQRDILVTPKRIEYARQRENELFDSLKDLTNQKQEQLRSLIQSTVADMTEDLLEQAGNYRFTDLEVSQEGKIQSQKDIKRCTEQIQDLVLARLNACVVEKLIGSVELLRESFLGTLQRCLASLEKIDGDLETSTTVALRQILNAAYQVEVSVRTSSSVVRIIWERMKEFFQSIKPFKTPTRVDTEWKRKVAQTMINNLDESKLAKSICSQFRSRLNNSHESFSTSLRQLEQKHSGRLEKTEEQRMKVRKVYAPRLARLALESTSLRDMVLYGMPKLEREIGRGQYGVVYSCRSWGGVTHCAVKSVVPPDDKHWNDLAMEFHYTRSIAEHDRIVAVIGSVIDHGYGGMGCSPAVLLLMERMQRDLHTAIKANMELPERLHVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKHDRGKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGKYDNSVDTYAFGILLWYVCAGHVKLPQAFEQCANKDHLWTSVKKGVRPERLRPQFDDASWNLMKSSWAGEPSERPLLGEVQSKLQDIYTKALAKREAEGGGGGGAKEQQNLKSDTL", "function": "May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. May play a role in the embryonic development.", "AFDB_id": "AF-A2CI35-F1-model_v4" }, { "swissprot_id": "A7YSY2", "sequence": "MAPDSGSFPEGPPLKLLPVDTRDRGTQRCRLGPTALRALGAHLGSAVKISLPDGGSCLCTAWPRRDGADGFVQLDPQCTSPGSAVGAPGSGGIINLNRLRLVPCPPLRSLAVWPELREQAGASGAPSPAAVLEAVQELLRNRPVSQGYVVAAPPGAPGPVAALHIVSGAPSPNPAGLVTPRTHISLSEVPPSEEEPQPEVPLGGLSEAADSLRELLRLPLRYPRALASLGLEVPRGVLLAGPPGVGKTQLVRAVARETGAELLAVSAPALQGARPGETEENVRRIFKRARELASRRPTLLFLDEVDALCPRRGGPHQAPESRVVAQVLTLLDGIGEDREVVVVGSTNRPDALDPALRRPGRFDREVVIGTPTLRQRKAILQVITSKMPISGQVDLNLLAEMTVGYVGADLTALCREAAMQALLHSEKNQDNPTIDETDFLEAFKKIQPSSFRSVIGVTDIKPVGWEQIGGLEDVKLKLKQSIEWPLKFPREFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCRCSFVSVSGADLFSPFVGDSEKILSQVFRQARANTPAIVFLDEIDSILGSRSISRTECNVQDRVLSVLLNELDGVGLKTIERRGSKSDQHGKCKQLEKNEELEFQEIFNSNVIVVAATNRPDVLDDALLRPGRLDKIIYIPPPDEKGRLSILKVCTKNTPMGPDVSLEKVAAETCFFSGADLGNLCKEAALLALQENGLEVTTVKQEHFLESLKTVKPSLSHKDLTLYKNLFQKKEFSILEDI", "function": "ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Acts together with SPATA5, C1orf109 ortholog and CINP.", "AFDB_id": "AF-A7YSY2-F1-model_v4" }, { "swissprot_id": "G2TRM0", "sequence": "MSTPTTVYRSLLRQLREMNVIYKTSTLKQKKGFTKTQKDFLVYTKACLRNNKVEQLSKFQEVVAFLKSGNQHELLFNRHHPLANVNELEKVKLAARRVGLESPE", "function": "Needed for the assembly of the mitochondrial F1-F0 complex at high temperature.", "AFDB_id": "AF-G2TRM0-F1-model_v4" }, { "swissprot_id": "P43057", "sequence": "MSTSQPSQQQNPEQVVNDIRQKIEKERKIIQGFNDVKRNTNNPEVIQKWKSKIIESQSMIDYYQETMNKLTRQMQRLNTNSSSRTASRSSVISEYKPSYSNFDLIKYECPSLGNKIQFMLQYLEFKLQVENKYSEANKKLSHLYLMDGDKSSSNAAEGGRAESDQRIQLLEKALKKYQKFSINDHEFDRDYEIMDSTKHSRKLLTGRLTVSITCIRDVDHIATALAKKRETVVVIKVDDLEKARTKPSKNDNWNEEMVIDVDKSHEIELAVMDKQNGIYVPVAVNWFSLFDLAEEIRKKKVAKDQGSSGWLPAANLPQTGGSGAGTGSSMTGGASYGATSPLPAHNDLRPSVSPSSDAKENKVSVSTWLSLEPGGQMLINLNFEKSITNGKQFRGPLGRHGAIRQKKEEVFEKHGHQFVQKQFYNIMSCALCGEFLRYTGYQCQDCKFLCHKKCYQKVVTKCISKSGSDYDAAQLNHRIPHRFEPITNHGTKWCCHCGYILPWGKKNVRKCTECGVMCHAQCTHLVPDFCGMSLQMANEILATIESTKVSPKKAQHQQSHAKPLPPKPPIESKPSMDSEETLHNEPSYKSLRPASVVHQDTNFVSKLPTTVQNKYQEPVELPPQQQNQVVPSTRRRGHGSTDLSFETGYGQQQHQHHRDVPQIVVEDHQHYNSNDNRDVEMEESKDEFDNFDYNNKYTENEILTDVQQDQVRSPFADQIQGVPETSHAKQQNQQVQQVQQQEELGHQRTHSSGKSGKSKRRKRKVGLDDFQFLAVLGKGNFGKVMLAESRHTSKLCAIKVLKKDFIVENDEAESVKSEKRVFLTANKEMHPFLLNLHCCFQTENRIYFVMEYISGGDLMWHIQKNRFTAKRAKFYACEVLLGLKYFHDNGIVYRDLKLDNILLTTKGHIKIGDYGLCKEDMWHKSTTSTFCGTPEFMAPEIVAGKAYDRSVDWWAFGVLLFQMLLCQSPFKGDDEDDIFNAIENDEVKYPINLSRQTVLVLQALLTKDPSQRLGSGPKDAEEIMEHPYFHDVNFDDVLNCRIPAPYIPEVQSEHDYSNFDKEFTSETPRLTPVETVLTSEMQEQFRGFSHISDNATI", "function": "Necessary for osmotic stability.", "AFDB_id": "AF-P43057-F1-model_v4" }, { "swissprot_id": "Q6CQW3", "sequence": "MASVRKRKMAKSSVKKVSRRNKDKQKQVNIKGNPIIAENWDYSLTLAQNYKKLGLKVKMGKFAGGEEADLSKVIKKDVYEHSAFSDDESEDEKDSQGEEDEDDVNLEELNSDGEYDESKIPEGEARIKRDDDGNIVKVYYGKRKAIDIDMDVEELRRENEKNEVKTEVVKKLEAYASRPVAKKERGLSQREDQWLEQLYKKHGDNYKKMFFDKKLNVYQQTENVLRRKILKWKELHNIE", "function": "Involved in the biogenesis of the 60S ribosomal subunit.", "AFDB_id": "AF-Q6CQW3-F1-model_v4" }, { "swissprot_id": "Q9FD10", "sequence": "MPLSVGQGYFTSSISSEKFNAIKESARLPELSLWEKIKAYFFTTHHAEALECIFNLYHHQELNLTPVQVRGAYIKLRALASQGCKEQFIIESQEHADKLIIKDDNGENILSIEVECHPEAFGLAKEINKSHPKPKNISLGDITRLVFFGDSLSDSLGRMFEKTHHILPSYGQYFGGRFTNGFTWTEFLSSPHFLGKEMLNFAEGGSTSASYSCFNCIGDFVSNTDRQVASYTPSHQDLAIFLLGANDYMTLHKDNVIMVVEQQIDDIEKIISGGVNNVLVMGIPDLSLTPYGKHSDEKRKLKDESIAHNALLKTNVEELKEKYPQHKICYYETADAFKVIMEAASNIGYDTENPYTHHGYVHVPGAKDPQLDICPQYVFNDLVHPTQEVHHCFAIMLESFIAHHYSTE", "function": "Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and negatively regulates the formation of Salmonella-induced filaments (Sifs) in epithelial cells. Has both deacylase and esterification activities in vitro, but esterification is probably the dominant activity in host cells. Significantly contributes to cholesterol esterification, which reduces cellular cholesterol in cells and abrogates the ability of SifA to associate with cholesterol and LAMP-1 vesicles.", "AFDB_id": "AF-Q9FD10-F1-model_v4" }, { "swissprot_id": "Q54F46", "sequence": "MASIVMKSQHSLGYPNIGNINRSDYDSYEQQYNNPTGSKQYNNNNNNNTNTNEINNGTNTNLNPNNMYGMYNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNINNNNNNNNNNNNNNNNNNQHLSQSQQLSPTPYSSNSFSKLLSRSTNDLMLDQDDPSKKKRKRTSPDQLKLLEKIFMAHQHPNLNLRSQLAVELHMTARSVQIWFQNRRAKARNMEFKPQLSHGGSDLIYNALGSQNGMNSMGGGGGNGGGNGGGGMNGINNILNGNHNRNLNKYIPHGGNSINGNMGGGGGGGGGSHNHHHHNHNHNHHNHNHNHNHNQPLSNGDCGEKFSVASAWNKILLHPNNIDFLIRYNPDDPNSIDVNARDSKGLSLLFTAAFLGYEYQVRRLIESGANPNIKDNQGNTPLIAASVLGNQPIVELLLEHRADPNLVNDEGVSPLFSACKGGHLQIASSLLDHDAEVSVKTKINGETPLHIASLKGFEKICKLLIETEAKASVIDSNNRTPLHHACIMGYFSIAKLLICNGADMNAIDIDGHTPLHTSSLMGHDLITRLLLENGADPNIQDSEGYTPIHYAVRESRIETVKFLIKFNSKLNIKTKNGQNLIHLSVQFASLMMGQMIFESKGCEIAADDSDDQGYTPLYLAAKAGKTNFVKYLLSKGASKKIALEKLIQENQDKEIIQMLESTVTKSSNNNNSNSNINNINNINNINNINSQPNTNSDNNNNNNNNNFNENYSNGNNEQSQPPGNKFEEDDEDDFYDRVYKKSYTNRIISNSFSYQQKLNSGNGISVNSGNLED", "function": "Putative transcription factor, that seems to be involved in anterior-posterior patterning of the slug, probably by controlling the proportions of prestalk and prespore cells.", "AFDB_id": "AF-Q54F46-F1-model_v4" }, { "swissprot_id": "Q7L0X0", "sequence": "MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAPSPAGDPWQRATKHRLGTEHQERAAQSDGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSASVRWAVREHRSPRPLGGARFRLLFDRFGQQPKFHRFVYLPESSDSATLRELRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTLPEAGSRGGVDYQLLTLALLTVNALLVLLALAAWASRWLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLIEFPCDRFMDSAGGGAGGSLRREDRLLQRFAD", "function": "Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.", "AFDB_id": "AF-Q7L0X0-F1-model_v4" }, { "swissprot_id": "J9VL95", "sequence": "MAFNPNPEKTTSCCSTSKAQDKCTCPKGKCECETCPKSTKTPGSGPCNCGVKEKVSTCGCNGSGAACTCPPGQCACDSCPRKAKSVSTCGCGGSAAACSCPPGKCACDSCPKQAQEKVSSCACNGSGGACTCPPGKCSCSGCPAQAKENPADQPTTCGCQGVGVACTCPPGQCACDGCPAKAK", "function": "Copper metallothionein that protects the cell against copper toxicity by tightly chelating copper ions. Required for antioxidant-mediated growth rescue in the presence of fluconazole. Acts as a critical factors for lung colonization and virulence.", "AFDB_id": "AF-J9VL95-F1-model_v4" }, { "swissprot_id": "Q8TD07", "sequence": "MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS", "function": "Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.", "AFDB_id": "AF-Q8TD07-F1-model_v4" }, { "swissprot_id": "P23201", "sequence": "MGTSSEVSLAHHRDIFHYYVSLKTFFEVTGENRDRSNSTRAQKARAKLLKLSSSQFYELSTDVSDELQRRIGEDANQPDYLLPKANFHMKRNQARQKLANLSQTRFNDLLDDILFEIKRRGFDKDLDAPRPPLPQPMKQEVSKDSDDTARTSTNSSSVTQVAPNVSVQPSLVIPKMASIDWSSEEEEEEQVKEKPNEPEGKQTSMDEKKEAKPALNPIVTDSDLPDSQVLARDITSMARTPTTTHKNYWDVNDSPIIKVDKDIDNEKGPEQLKSPEVQRAENNNPNSEMEDKVKELTDLNSDLHLQIEDLNAKLASLTSEKEKEKKEEKEEKEKEKNLKINYTIDESFQKELLSLNSQIGELSIENENLKQKISEFELHQKKNDNHNDLKITDGFISKYSSADGLIPAQYILNANNLIIQFTTRLSAVPIGDSTAISHQIGEELFQILSQLSNLISQLLLSADLLQYKDQVILLKASLSHAITSIRYFSVYGPVLIPKITVQAAVSEVCFAMCNLIDSAKIKSDSNGESTTSNEGNRQVLEYSSPTATTPMTPTFPSTSGINMKKGFINPRKPASFLNDVEEEESPVKPLKITQKAINSPIIRPSSSNGVPTTSRKPSGTGLFSLMIDSSIAKNSSHKEDNDKYVSPIKAVTSASNSASSNISEIPKLTLPPQAKIGTVIPPSENQVPNIKIENTEEDNKRSDITNEISVKPTSSIADKLKQFEQSSEKKSSPKENPIAKEEMDSKPKLSNKFITSMNDVSTDDSSSDGNENDDADDDDDFTYMALKQTMKREGSKIEKNNDSKLPANIVELDLHESPESVKIESPESIKEITSSEMSSEMPSSSLPKRLVEDVEPSEMPEKGASVESVRKKNFQEPLGNVESPDMTQKVKSLGMTGKAVGPESDSRVESPGMTGQIKSLNMAGKVVGPEADSRVESPGMKEQIKSLGMTGKITAQESIKSPEAARKLASSGEVDKIESPRMVRESESLEAVGNTIPSNMTVKMESPNLKGNTVSEPQEIRRDIASSEPIENVDPPKVLKKIVFPKAVNRTGSPKSVEKTPSSATLKKSGLPEPNSQIVSPELAKNSPLAPIKKNVELRETNKPHTETITSVEPTNKDANTSWRDADLNRTIKREEEDEDFDRVNHNIQITGAYTKTGKIDYHKIPVDRKAKSEAEVHTSEEDIDESNNVNGKRADAQIHITERKHAFVNPTENSQVKKTSHSPFLNSKPVQYENSESNGGINNHIKIKNTGETTAHDEKHYSDDDDSSYQFVPMKHEEQEQEQNRSEEEESEDDDEEEEDSDFDVDTFDIENPDNTLSELLLYLEHQTMDVISTIQSLLTSIKKPQVTKGNLRGESNAINQVIGQMVDATSISMEQSRNANLKKHGDWVVQSLRDCSRRMTILCQLTGDGILAKEKSDQDYADKNFKQRLAGIAFDVAKCTKELVKTVEEASLKDEINYLNSKLK", "function": "Involved in pheromone-induced morphogenesis and efficient mating, perhaps as a cytoskeletal protein.", "AFDB_id": "AF-P23201-F1-model_v4" }, { "swissprot_id": "A1AV41", "sequence": "MSMNRFRETLQRATEEMQFELSGEQLRDFQLFAMELKKWNLRVNLTAITDDGEIAVKHIADSLFLARQLDSTERVLDVGSGAGIPAIPLKIAIPGLETVSVDAVGKKIHFQRHVARLLRLQGFQALHARIESLHATHGRSFDVITSRAFSDLGLFVRLTAPLLAEGGRLIAMKGPAAGDEMEEAKTTLAALRHEVCSLHPYRLPLESGERCLVVMRPVSKI", "function": "Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.", "AFDB_id": "AF-A1AV41-F1-model_v4" }, { "swissprot_id": "A0A0H2VA68", "sequence": "MKTGSEFHVGIVGLGSMGMGAALSCVRAGLSTWGADLNSNACATLKEAGACGVSDNAATFAEKLDALLVLVVNATQVKQVLFGEKGVAQHLKPGTAVMVSSTIASADAQEIATALAGFGLEMLDAPVSGGAVKAANGEMTVMASGSDIAFERLAPVLEAVAGKVYRIGSEPGLGSTVKIIHQLLAGVHIAAGAEAMALAARAGIPLDVMYDVVTNAAGNSWMFENRMRHVVDGDYTPHSAVDIFVKDLGLVADTAKALHFPLPLASTALNMFTSASNAGYGKEDDSAVIKIFSGITLPGAKS", "function": "Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).", "AFDB_id": "AF-A0A0H2VA68-F1-model_v4" }, { "swissprot_id": "Q89VI2", "sequence": "MIHAISAVNRHLYEDVLEQHFRLRHDIFVEERHWETLRRPDGREVDSYDDEDTVYLLALEGRRVVGGHRLYPTTKPSMMSEVFPHLAAVRGCPSDPLIWEWSRYFVVRDRRDGALNLQLMAAVQEFCLDQGIAQVSAIMETWWLPRFHEAGFVVTPLGLPALVENAWTMAATVDIRRQTLDVLHDRIGMPSIVQQDGPRLDAVARANLCGLAAAQRKSA", "function": "Catalyzes the synthesis of IV-HSL (isovaleryl-homoserine lactone), a quorum-sensing (QS) autoinducer molecule which binds to BjaR1 transcriptional regulator to activate expression of QS-dependent genes. Is active with isovaleryl-CoA but cannot use isovaleryl-ACP as acyl donor.", "AFDB_id": "AF-Q89VI2-F1-model_v4" }, { "swissprot_id": "D3SGB1", "sequence": "MMHLLRRGAFAILLIVLLPSAALADLRLASWNIQHLGWNVGKDYPAVARIAAQFDFLAIQEVMNAEGIYRLRDTLEDATGAEWSVLYSDALGRNTYREKYAFLWREAAVEYVGGALTYIDEADRFAREPFSAVFRSRGTDQHFLAATVHITYGDRVADRVEEIEALRRYWDWLADVMPEYAGERILFGDFNLPPHHDGWASMRAVAEPLVTEGATTLSTHDRRYANLYDNLWVPKDHTLPLGDAGILPFPVVLSEVTGVYWDHEKARDRVSDHAPVYVLFEGNTLHDAVVAEIADQEAGCIDLNRASVSELTALPHIGEARAEAIKDGRPWNAVRDLKEIRGIGAGRLEEIKARGEACIEP", "function": "DNA nuclease able to digest short and long DNA substrate. Is resistant to ionic strength and thus active at high salt concentration.", "AFDB_id": "AF-D3SGB1-F1-model_v4" }, { "swissprot_id": "P74167", "sequence": "MAMAWLMGLGLALASVLWVELVRDCYHALAHVWSPLYRLHGWHHRVFRSDLSVVSTEIYQKAHWYNDVPEALVMLAFGIWPPLLTWMWQGFSQWPLILAASAGMVYTLGFLLSAIARGVGLPNADEITDLTHRPGPFLTPPAPWMVNRTYHWRHHFDDPNAYFCGTLTLVDKMLGTALSLKGKKIAVTGASGGFGQALLQELHQQGAKAIAITSCGQEVTVIGAEKTIPIRTEQWCIGQEDQLKDLLAEIDVLVINHGVNVHQRRDGQAIQEAYEVNTFSALRLMELFLATVKTNRHIATKEIWVNTSEAEVNPAFSPLYELSKRALGDVVTLKRLDSPCVIRKLILGPFKSKLNPVGIMSAAWVARQVVKGVKRDSRNIIVTINPITFIAFPVKEFFVSLYFRCFTKKS", "function": "Involved in the biosynthesis of galactolipids found in the photosynthetic membranes. Catalyzes the isomerization of monoglucosyldiacylglycerol (GlcDG) to yield monogalactosyldiacylglycerol (MGDG).", "AFDB_id": "AF-P74167-F1-model_v4" }, { "swissprot_id": "Q0T1X7", "sequence": "MKEKTIIIVGGGQAAAMAAASLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQQVLPANWWQENNVHLHSGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFTLHHAGDAARLREVLQPERSVVIVGAGTIGLELAASATQRSAAQRSAAQRRCKVTVIELAATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHVVDGEKVELTLQSGETLQADVVIYGIGISANEQLAREANLDTANGIVIDEACRTCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQIAAAAMLGLPLPLLPPPWFWSDQYSDNLQFIGDMRGDDWLCRGNPETQKAIWFNLQNGVLIGAVTLNQGREIRPIRKWIQSGKTFDAKLLIDENIALKSL", "function": "Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.", "AFDB_id": "AF-Q0T1X7-F1-model_v4" }, { "swissprot_id": "Q9M1W7", "sequence": "MCYRQETMSGLLDGIPEAVALRCLAHVPLHLHPNLELVSRSWRAAIRSHELFRVRKELRSSEHLLCVCAFDPENIWQVYSPNCDRWLTLPLLPSRIRHLAHFGAVTTAGMLFVLGGGSDAVSPVTGDHDGTFATDQVWSYDFVQRQWTPRASMLVPRAMFACCVLQGKIVVAGGFTTCRKSISGAEMYDPENDVWTSIPDLHQTHNSACSGLVVNGKVHVLHKGLSTVQVLESVKLGWDVKDYGWPQGPMVVVEDVLYVMSHGLVFKQEGDTWKMVASASEFKRRIGMAMTSLSDEVLIVGGVIGPDRLNWDIKPLSDVDALTVGNDRPAWRSVAPMTRCRGTILGCTQLTI", "function": "Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q9M1W7-F1-model_v4" }, { "swissprot_id": "Q9LKL2", "sequence": "MDLNGECKGGDGFIDRSRVRILLCDNDSTSLGEVFTLLSECSYQVTAVKSARQVIDALNAEGPDIDIILAEIDLPMAKGMKMLRYITRDKDLRRIPVIMMSRQDEVPVVVKCLKLGAADYLVKPLRTNELLNLWTHMWRRRRMLGLAEKNMLSYDFDLVGSDQSDPNTNSTNLFSDDTDDRSLRSTNPQRGNLSHQENEWSVATAPVHARDGGLGADGTATSSLAVTAIEPPLDHLAGSHHEPMKRNSNPAQFSSAPKKSRLKIGESSAFFTYVKSTVLRTNGQDPPLVDGNGSLHLHRGLAEKFQVVASEGINNTKQARRATPKSTVLRTNGQDPPLVNGNGSHHLHRGAAEKFQVVASEGINNTKQAHRSRGTEQYHSQGETLQNGASYPHSLERSRTLPTSMESHGRNYQEGNMNIPQVAMNRSKDSSQVDGSGFSAPNAYPYYMHGVMNQVMMQSAAMMPQYGHQIPHCQPNHPNGMTGYPYYHHPMNTSLQHSQMSLQNGQMSMVHHSWSPAGNPPSNEVRVNKLDRREEALLKFRRKRNQRCFDKKIRYVNRKRLAERRPRVKGQFVRKMNGVNVDLNGQPDSADYDDEEEEEEEEEEENRDSSPQDDALGT", "function": "Controls photoperiodic flowering response. Component of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Positive regulator of CCA1 and LHY expression.", "AFDB_id": "AF-Q9LKL2-F1-model_v4" }, { "swissprot_id": "Q81WT0", "sequence": "MKNERHVLIVFPHPDDESYCVAGTILAYTQRNVPLTYVCLTLGEMGRAMGNPPFATRESLYAIREKELKRATNILGIKDLRMMGYRDKTLEFETPGELRRVIQKCVEELNPSLVISFYPGYAVHPDHDATGEAVAEALATIPENKRPTFYAVAFANNHEAEIGPPHVKNEVKEYVPKKLEALQAHASQFATKVTELKREYEDGVTETVEWLEREPFWIYPFKDKNK", "function": "Involved in bacillithiol (BSH) biosynthesis. Catalyzes the second step of the pathway, the deacetylation of N-acetylglucosaminylmalate (GlcNAc-Mal) to glucosamine malate (GlcN-Mal). Could also be involved in bacillithiol-detoxifying pathways through formation of S-mercapturic adducts.", "AFDB_id": "AF-Q81WT0-F1-model_v4" }, { "swissprot_id": "Q99222", "sequence": "MLRRELNNSISNRSIENESFPFERPNVSYIISAEFDNKLGPILKHQYPKDIPGFNQFSHEQRNGNTSVSMNLASLMIPSSIERNPGKQDITVFTLYYNKFTQNYQLFPVPKDPRFSFNLHHREQSDGSVTNSIYYDAENHQDAKNNRYTIVLEDDELECQEVQNNQKAIDNEPLFFINVANTVLDTTNDRGAVIKSIAIGTPLKTFFAFKNIIVLVLDLYMKAPTQAAATDILLDCFNMLNSIDLTLINDIHSKSSIQEVLHSIHDESIITKVFLDPDSTLKKLFCINGFDTKDKYGNIVTFHDQLIQYHFTRFQPKTLPPFLLKIPLQFNMIRREPIYIENDYNELVLKFLDKFVPYLLKAGQKVNAWKLVINSTKLSKEDLCAFILSLANITATYASDPQSYFKGNAALIFPYMDISLVDGLRAYVASNSDFVGCFAIIGTANPIFRYQLDIWDYYYDVDEGVFYENNSPEKEKPDTVAEVKIGPNPLRKIFNRPHFSTNAVNESQVNLGQKLFSLLIDEYHDSDTIMSVLRRLNVLQLENLLDALKRREIPPNIALKDEYIMFYKDFFIFPEFFDYFTLHSIELLSNLDNCLFSLGNTCQLFSTEQIYSQLSQILDIVKELFRMVSVSRTNIEKFLNACLNYSPFKILPTAQLHGDNISRWSFESEVRQGFDNFNSYMGIEKDPHGVIVSAIDLFTQIYSFDILAFFLTFITKESGQDLPFTKSLSRRRTYLTRIAQSSSLRQFLQLSTRPNIRILGGNGQGTGNSNYPEFTNASSVISPKLRASPLLERRASKICYAITKLLYRLECHPIGMALLKKYLHNQLREAYLESKRHFISKKGDSTNTSSTIASSSFAGASVPLSSNESGMLNGLKQINEQQESTLETTQKED", "function": "Involved in actin patch polarization. Required for maintaining a proper budding pattern in yeast cells. Required for proper polarized localization of the ADP-ribosylation factor ARF3 at the plasma membrane.", "AFDB_id": "AF-Q99222-F1-model_v4" }, { "swissprot_id": "Q83MT2", "sequence": "MLHRPRITPAVANARRAMLNTLPADLHNQLVLIALSGGRDSLAAMVIASWVIPRLNGRVGAVVVDHGLQENSARIADEVRIRAEQFALNPILIKRVSPSRVSAGPEASARIARYAAFYDALEETKAYAIILAHTLDDQAETVLLGLMRGSGPSSLRGMKAVSYTPEDCRYMNNKACNSVTAVYAHNTQRCSCDSTQRCSCDSRPYPPPPEPRNENRSYFPHPSCKCVEGSATRFTNADIDSRFGVFIRPFLDITRHETGKICEFYGLDYWNDPHNEDVRFSRVRIRHNVMPVLENEIGPGVKYALSRTAKLAQLDTEYLDHLSNELLDEIASKESDWSIRLPINTLQKTPVPIRLRVIRLAALQYFTVSLSFKHTRQIERLLCSSCDIKHVNLPRLITAQRVGNYIYMHTLRGKL", "function": "Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.", "AFDB_id": "AF-Q83MT2-F1-model_v4" }, { "swissprot_id": "O13990", "sequence": "MQFLSSFVFAALALLPLSAMAVDEAASEIASSTKPASTNGTLSFCLGVKHADGTCKYTDDYLADFEVLAPYTNMIRTYATSDCNTLEYLLPALAQSPYNFSAILGVWPTDDAHYDLEKQALMQYLPQYGVDHVRAITVGSEVLYRNDLPADVLAERIYDVRGLVQQKLGFDVPVGTADSWNLWAGGSGDVVITASDFIMSNDFPYWQGQNTSNMTNTFISDTLAALERVQSVKGTNNVTFWVGETGWPTDGPSYGEADATVDIASEFFQEALCNIRRKGIDIFFFEAFDEDWKGDSSSVEPYFGAMYSNRTLKYNLNCTSE", "function": "Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.", "AFDB_id": "AF-O13990-F1-model_v4" }, { "swissprot_id": "O60906", "sequence": "MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ", "function": "Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo. Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine.", "AFDB_id": "AF-O60906-F1-model_v4" }, { "swissprot_id": "B9JNG1", "sequence": "MNPSPLSIHSALSSDALRIDAAAEVDRIAQAMRDQVRNKMRRRGLVIGLSGGVDSSVCAALAAYALGAQNVFAIFMPENDSDPESLSLGQEVAKAFSLEGAIEDIGSALAAMGCYERRDDFIRQVEPAYGSGWSCKVVISSPLAGEGYALSTLVLQAPDGSQTRHRMPASVYLGIVAATNMKQRTRKQMEYYHADRLNYAVLGTPNRLEYDQGFFVKNGDGAADLKPIAHLYKSQVYQIAEYLGVPEEVRRRPPTTDTWSLTQTQEEFYFALPYDRMDLCLHALNEGLGVEETAKATQLTTDQVERVWLDIHSKRKATRPLHLAPLLVQPVF", "function": "Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.", "AFDB_id": "AF-B9JNG1-F1-model_v4" }, { "swissprot_id": "Q5A1B3", "sequence": "MKFTIVLFTLISVTVAAAATTTTTAAANRIQNKAYAYYYCNSYCTQAVNDENSCGYYDTDVSNQEYYACLCTKSSYYNNLRSCDCFTKVVYYYSTSICSRANVGTYVGGRTSTTWGVSATKYRSSTSTSSLTRKSSSIGASPSIAIASSTKESSSTESSSSLEQSSSAGQSSSTEQSPSTEVSSSSSIEESSSNQDISSTDSITTISSDSSTGNTDSPTQGGGGNSGNNGSNGDGGNDASGGGGVVNENEQASSPPSSQSSTNSNQPNSSQTAPGAANYLSSVSVGTLMILVLGLI", "function": "Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.", "AFDB_id": "AF-Q5A1B3-F1-model_v4" }, { "swissprot_id": "D3BAV8", "sequence": "MMRSTLSLLQKCRLPNNNGSLLSFKNNQVVNQTALFSMKSNQQYRFYSTDVKDLAPLIKELRNRTSAPLKDCKEALIQNKNDIEKATSWLHEKGKSTANKFADRAVVEGTISIVVNNGKAVILEMNSETDFVSRGETFRALADQISRATLESNLLAQSLAEIKPDTIAPQPASGSTVADLIVGTVAKLRENIRLRRVHAIDASNQPNTIVAGYAHDPSGTNQFGRLGSLVQLQYEGGQPDIAALNQLARNIAVHIVGVGPSYVSIESVPKVLLDEAIANKRHPNSLYDEVVLLEQKYISGEDNETVKAAVQRISKQLKTNITIKSFVRYSVGEGMEKKVENYGAEVMEKINKAK", "function": "Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.", "AFDB_id": "AF-D3BAV8-F1-model_v4" }, { "swissprot_id": "Q10268", "sequence": "MIRNTLAFLAILFLLIPTALLIIGSVSVPSTRMTLAKVEGTEFGIFGTCTGNGTDCTETSFGYNASSSLIDDFYYKGDKRLVLSKVLITHIISAFLSFLSAIFVFFSIFLVNQAVNIINIIVVFITTLLTCLAFAIELVLFLPHNTWQSYVTAGAIGSDLIAILALCLRSVSISRIGQKSARLEHVDTMNSSYSSYKTDVKYPLALDDKLSSVPTLPKFHDALTSTSEFGPPSDSGDTVGTTQYPGDIKYATGYESTVASPVPSRVAKLSSRDTPSIIADYDEFRKSESSPSRSSVLSTSKPEVHETEGYCPHKTGNRPGFPSLNIPRTRPTTAGIANTQFDLEPYRNRQAGSISSEGTDSRFFDVENQVSVAQTPSVKPEMFPKTARPFAAIHANASSTQLRNTENITHPGIPNHFAKTTSSVFDEPPATRMPQTRSPVNDHSSFPSDLPIKGEMSTNMTGAPRVGSRNNSSNDLHAQAGMLKNVGNGPRNAPRNNSSNNLHAQGGMPMNMRGPRGAPRNNSSGDLHIQSGMPMNGRNGPRDTSRNNSSSDLYAQSGMHPNMNNGHRGAPRNNSSNDLHAHGGMPVNMRGPRNTSRNNSSSEFNAQIPMNLRNGPRNASRSNSSTDLFGQSGIPGNSRGMPTSPNSRNNSALDLSMHGIPLANNSRQFKRPSYGNMSRPSFELNGSRNPSHGSLNTAHAGMGYGPRSMMRDPQNLSNVPPVSNTLDQLSGNADFELPVRGNRNNRRGPGGNRMIR", "function": "Required for correct cell separation at high temperatures.", "AFDB_id": "AF-Q10268-F1-model_v4" }, { "swissprot_id": "Q19848", "sequence": "MPPKKAPAKKLHELAAEVRVGHKINDISKKTFIVGKQFATGGFGRIHTCTEEGKSQQMVMKIEPSTNGPLLTEVVVFNRILKKELIESYKKKKKISWIGLPYLIANGYFTYESEKMRYMIIPKYATSLEAVRETNGGTLAMKDSLTVASCILDALEYLHESDYAHADVKAANILLEKQGVYSTAVLVDFGLAHRTTNNVDKPDKKRAHNGTCIFTSTDAHRGNNPSFRGDIEILAYNLMMWATGTLPWMALESSPEKVFDAKQKFIAGLPGTLQNVLKNESSAVVGCIASMFDISMKTNYTDKVDMGKLKKLVTDAIQKTSSDGKKTPTRQKKLAEEDKNAVTPKRSTRRLAVKEESDNKDNDEVEVKPEKKATPRKRTTRKAVEVNNDSDDNEEQYENPKSKSSRTQTKSKRAKEEDVDDEEEIIIPKSSRSRSKVQLSGEGSDVTTPSSAASTSRSRSIRLGLTSSTASSNKVAKKIEQKYKRLSMNKSSLVPVTISVASDKSPTTSTPSSSSGLRSKRKSSEDVGEGITLKTQVLITPAIKKAKTKSGISSATKASPTELRRVPGVRNFPKGRRSMIIKETSAKYKERLASRQTKPTFDDSSCSSEV", "function": "Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage.", "AFDB_id": "AF-Q19848-F1-model_v4" }, { "swissprot_id": "Q00813", "sequence": "MTQDYEVEFVERGEREARILVRGITPAFANGIRRAMVADVPTFSIDTVRVIENTSVMFNEQIGLRLGLVPLTTDLDDFEIGDEVTLSLSVDGPSTAYSSDLVSSDPMVEAADDNIPIIDLKEGQRLEVEADAVLDTGREHAKHQGGVAVGYRHLQQVEVVGDLGEFEDDDPNILRGVIEEQAAEHAAGDATNGELVATDEFDNDLRNRYPGKDVEVSDVPNAFVFHVETDGSFTTEELVLRAVETLRDRATELKDAVQL", "function": "DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "AFDB_id": "AF-Q00813-F1-model_v4" }, { "swissprot_id": "P0A1V9", "sequence": "MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR", "function": "This is an oxacillin-hydrolyzing beta-lactamase.", "AFDB_id": "AF-P0A1V9-F1-model_v4" }, { "swissprot_id": "A1X157", "sequence": "MATDGASCEPDFARAPEDAAGAPAEAARKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMSTQLAAAESRQKKLEMEKLQLQTLEQEHKTLAARLEEERVKNKHVVLMLVKECKQLSGKVIEEAQKVEEALAQLEEEKKRASGLEEELSGEKRRSAEMEAQMEKQLSEFDTEREQLRAKLSREEAHTTDLKGEIDKMKKMTEQLKRGNDSKPSLSLPRKAKDRRWVSVSVGTEGPGTGSVACQTDLGVESTDHVKKLPLTVPAKPAAGSPLVAASAKGSGGATAPLARPGVDRQASHADLIVSSPPTIPPPNTNKIEENGPSTSSGPDTPSSTAPLPSNAAPPAIQTPNAAAQNYPAQAPSTHTVHSPCANAALHPALTPRVQAVRFRFQGNANNDQDQNGNNTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGAPPRPGAPPTGEGSTHPPVGRTSLKTPGAARVDRGNPPPIPPKKPGLSQTPSPPHPQLKVLLDSSRASNAGPKVDHKTVALPPTSVPQGNRVINEESLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWRAETPGLKPPACSDRPLVIPTTIAFRCPINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINHSCEDGHSALYSAAKNGHTDCVRLLLNAEAQVNAADNDGFTPVCAAAAQGHVKCVELLVAYHANINHAAAEGQTPLYLACKNGNKECIKLLLEAGTDRSVKTRDGWTPVHAAVDTGSVDGLKLLLYHRAPACGDGLDTEASRLGVFDLDEGEANPESTPTPVIPADLINHANREGWTAAHIAASKGFKNCLKILCRHGGLEPERKDKCNRTVHDVATDDCKHLLENWNALKIPLRISVGETQGDNSGPDEFESEHTICALNIRKPTSWDDFSKAVSQALTSHFQAISSDGWWSLEDVTLNSPAEASIGLSATSVLSITLGNVPWSVGQSFTQSPWDFLRKHQAEQVTVLLSGPQEGCLSSVTYASMIPLPVLQNYLRLVEQYHTVIFHGPEGSLQDYIALQLALCMKHRQAAVGFSCDIVRADVDAGFSKEQLVDLFIKSACLIPAKQSPASKKTIIILENLERASLSELLGDFLAPLENRSPESPYTFHKGNGTSECYYFHENCFLVGTIAKACLQGPDLLVQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFRGKLPSPGEPVCKMVDWALSVWRQLNSCLSHLGTPEALLGPKCFLSCPVVPGHAQATVKWMSKLWNAVIAPRVQDAILSRASVNRQPGLGQTAAKKHPSPGQQAVVKAALSILLHKAVLHGCPLPRAELDQSMADFKGGSFPLSLVSSYSSCSKKKGENGAWRKVSTSPRKKSGWFFSPTWSKPDLSDEGIKSKTISQPNCNRNASLSRQKCLENDLSLALNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADTRDDLRRFDSSRNRPAPSATVTNPRMPVSQKEVSPLSSHQTMERSNRTLKTELGVSRVKSFLPVPRSKITQCSQNTKRSSSSSNTRQIEINNNSKDEIWNLRNNEQIEKPNQ", "function": "Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.", "AFDB_id": "AF-A1X157-F1-model_v4" }, { "swissprot_id": "Q089C0", "sequence": "MQQQTSADMNLLWGQLILEELARLGVKHVCMAPGSRSTPLTLAAASQTQLTRHIHFDERGLGFMALGLAKASNAPVAIITTSGTAVANLYPAIVEAWLTHVPLIILSGDRPPELIDCGANQAIIQPAIFAQYAKQVNLPTPDLGYPANALLSTIDHALANQHQPVHINCMYREPLYPTELVTLAHVKKTASVTTSTYLAPLNQWFENTKPLTRYASLTSAELPTTDTLMRFVHGKGVIVVGTLAPEDNPQQIVALAQKLGWPVLVDAQSQLRQHPGVIGHVDQLLLNPKANKQLEQAERILVFGGRFISKRLLQYIAQQSWHSYWHVVKHGDRLDPTHQSKEFYQASVQAVCQLPWPRSSQANWALQLLPLNESLESLFKQQIDNTTFGEAQVVRAIALAQSDQHILFIGNSLPIRLYDMYAPIATNTPAIYTNRGASGIDGLIATACGVAADKNAPTTLVMGDLSCLHDFNSLALLKQMTQPFVLVIINNDGGNIFNLLPVPNESLRNDFYRLSHGLEFGYGAAMFGLAYRQADDIESFNQAYQEAFEFNCASVIEVNVSPTQASDQITQISQWVKQH", "function": "Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).", "AFDB_id": "AF-Q089C0-F1-model_v4" }, { "swissprot_id": "Q05598", "sequence": "MTGLDRLSYQSRWAHVAPQRKFLLWLAMMILAFVLPPVGQGIELLIIAGLSCWLLRISLWRWCRWMAIPFGFLLVGVITIIFSISREPQMLLAGISVGPYWIGITRAGVVTANETFWRSLTALSATLWLVMNLPFPQLISLLKRAHIPRLLTEQILLTWRFLFILLDEAVAIRRAQTLRFGYCSLPNGYRSLAMLAGLLFTRVLMRYQQMTTTLDIKLYQGDFHL", "function": "Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity.", "AFDB_id": "AF-Q05598-F1-model_v4" }, { "swissprot_id": "Q96GJ1", "sequence": "MAGLKRRVPLHSLRYFISMVGLFSKPGLLPWYARNPPGWSQLFLGTVCKGDFTRVIATKCQKGQKSQKKPSHLGPLDGSWQERLADVVTPLWRLSYEEQLKVKFAAQKKILQRLESYIQMLNGVSVTTAVPKSERLSCLLHPIIPSPVINGYRNKSTFSVNRGPDGNPKTVGFYLGTWRDGNVVCVQSNHLKNIPEKHSQVAQYYEVFLRQSPLEPCLVFHEGGYWRELTVRTNSQGHTMAIITFHPQKLSQEELHVQKEIVKEFFIRGPGAACGLTSLYFQESTMTRCSHQQSPYQLLFGEPYIFEELLSLKIRISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGTGVIGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKSKEDGQSIVAVVNPARAGLHYKVIQAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLLGEPFVLQQAVPVDLFPHTPHCELVLLFTR", "function": "Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA. Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs. Specifically methylates the uridine in position 429 of 12S rRNA (m5U429). Does not affect RNA stability or mitochondrial translation.", "AFDB_id": "AF-Q96GJ1-F1-model_v4" }, { "swissprot_id": "Q03322", "sequence": "MNNSEDPFQQVVKDTKEQLNRINNYITRHNTAGDDDQEEEIQDILKDVEETIVDLDRSIIVMKRDENEDVSGREAQVKNIKQQLDALKLRFDRRIQESTQTTIPLEETVENSTLNTSMAENNDGGMSNPFQEQMLREQDVHLDGIHKTMQNLHIQAQTMGDELENQGQLLDNMDEGMDGVVNKLARGRRQLEWVYEKNKEKYDDCCIGLLIVVLIVLLVLAFIA", "function": "SNARE protein (of Qc type) involved in membrane fusion probably in retrograde traffic of cytosolic double-membrane vesicles derived from both, early and possibly late endosomes/PVC (prevacuolar compartment) back to the trans-Golgi network (TGN or late Golgi). It has been reported to function both as a (target membrane) t-SNARE and as a (vesicle) v-SNARE. Upon vesicle tethering to the target membrane, which requires additional proteins, a SNARE-pin is formed. This is a very stable 4 parallel alpha-helical coil bundle consisting of 4 SNARE domains (usually one of each type: Qa, Qb, Qc, and R), of which at least one is anchored in the opposite membrane. The formation of the SNARE-pin is believed to bring the two membranes in close proximity and to provide the energy to drive membrane fusion. Through its interaction with the VFT (or GARP) complex, it may also contribute to vesicle recognition specificity and tethering. Regulation of SNARE-pin formation also seems to depend on the phosphorylation state of the protein, phosphorylation by TPK1 causing inhibition and dephosphorylation by SIT4 activation.", "AFDB_id": "AF-Q03322-F1-model_v4" }, { "swissprot_id": "Q9ZVH0", "sequence": "MGDRNNDGDQKMEDVLLPGFRFHPTDEELVSFYLKRKVQHNPLSIELIRQLDIYKYDPWDLPKFAMTGEKEWYFYCPRDRKYRNSSRPNRVTGAGFWKATGTDRPIYSSEGNKCIGLKKSLVFYKGRAAKGVKTDWMMHEFRLPSLSEPSPPSKRFFDSPVSPNDSWAICRIFKKTNTTTLRALSHSFVSSLPPETSTDTMSNQKQSNTYHFSSDKILKPSSHFQFHHENMNTPKTSNSTTPSVPTISPFSYLDFTSYDKPTNVFNPVSCLDQQYLTNLFLATQETQPQFPRLPSSNEIPSFLLNTSSDSTFLGEFTSHIDLSAVLAQEQCPPLVSLPQEYQETGFEGNGIMKNMRGSNEDHLGDHCDTLRFDDFTSTINENHRHHQDLKQNMTLLESYYSSLSSINSDLPACFSSTT", "function": "Promotes periclinal root capforming cell divisions. Activates expression of its negative regulator SMB in a feedback loop for controlled switches in cell division plane.", "AFDB_id": "AF-Q9ZVH0-F1-model_v4" }, { "swissprot_id": "O94506", "sequence": "MSFPTDMETNEILDQLDKIDERNEDILLKSLKASKCTYKPWSREEFLRRLLTYRSRWAYVNDPQIGEINCCLNGWLCESNNILVCDVCRNKINLTALQQVDAENDSLNELPEKTKERLEVSLKEEHQDNCLWRLHKFPPDIYHLSVSAELVQVGRRFNSLSTRLVSTHLPEEMTLKRLEKVANKIRVDWEKEDAAVLLGIALTGWSEQVPGRLYVCNYCHRRLGVWNLQSEGQDFDVLEEHKKSCPWVIPQPFTDLLGWQQIFELLCKESIFQSTTKTMDVSQYTDYTFSLLQGLR", "function": "Involved in the export of mRNA from the nucleus to the cytoplasm.", "AFDB_id": "AF-O94506-F1-model_v4" }, { "swissprot_id": "P53256", "sequence": "MSVQAEIGILDHVDGSSEFVSQDTKVICSVTGPIEPKARQELPTQLALEIIVRPAKGVATTREKVLEDKLRAVLTPLITRHCYPRQLCQITCQILESGEDEAEFSLRELSCCINAAFLALVDAGIALNSMCASIPIAIIKDTSDIIVDPTAEQLKISLSVHTLALEFVNGGKVVKNVLLLDSNGDFNEDQLFSLLELGEQKCQELVTNIRRIIQDNISPRLVV", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP46 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.", "AFDB_id": "AF-P53256-F1-model_v4" }, { "swissprot_id": "B6A876", "sequence": "MEKEEKSNLIYDKDPGYVWDNKNECEGAAEETYQELNYEPSISADKLTWTPTRLAKTVFNTYEDDDDFNVLCYFTDWSQYDPRIINKEIRDTGGRSADILRLNTPDGRPFKRLIYSFGGLIGDKKYSADGNASIAVRLGVATDPDDAIANHKGKTIPVDPDGAVLASINCGFTKWEAGDANERYNQEKAKGLLGGFRLLHEADKELEFSLSIGGWSMSGLFSEIAKDEILRTNFVEGIKDFFQRFPMFSHLDIDWEYPGSIGAGNPNSPDDGANFAILIQQITDAKISNLKGISIASSADPAKIDAANIPALMDAGVTGINLMTYDFFTLGDGKLSHHTNIYRDPSDVYSKYSIDDAVTHLIDEKKVDPKAIFIGYAGYTRNAKNATITTSIPSEEALKGTYTDANQTLGSFEYSVLEWTDIICHYMDFEKGEGRNGYKLVHDKVAKADYLYSEATKVFISLDTPRSVRDKGRYVKDKGLGGLFIWSGDQDNGILTNAAHEGLKRRIKNKVIDMTPFYLDSDEELPTYTEPAEPQCEACNIK", "function": "Part of an orally active toxin complex (TC) with strong insecticidal effects on larvae of the Coleoptera Costelytra zealandica, Acrossidius tasmania and Adoryphorus couloni and some Lepidoptera larvae. The TC has an endochitinase activity (Probable). This subunit might aid infection by degradation of the larval peritrophic membrane (Probable).", "AFDB_id": "AF-B6A876-F1-model_v4" }, { "swissprot_id": "O30297", "sequence": "MRAAVVYKTDGHVKRIEEALKRLEVEVELFNQPSEELENFDFIVSVGGDGTILRILQKLKRCPPIFGINTGRVGLLTHASPENFEVELKKAVEKFEVERFPRVSCSAMPDVLALNEIAVLSRKPAKMIDVALRVDGVEVDRIRCDGFIVATQIGSTGYAFSAGGPVVEPYLECFILIPIAPFRFGWKPYVVSMERKIEVIAEKAIVVADGQKSVDFDGEITIEKSEFPAVFFKNEKRFRNLFGKVRSIG", "function": "Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.", "AFDB_id": "AF-O30297-F1-model_v4" }, { "swissprot_id": "Q9QYL0", "sequence": "MAQMVAGDQDAGTLWVPSQSESQTESDISTQSLRKPTMSYVILKTLADKRVHNCVSLATLKKAVSITGYNMTHNTWRFKRVLQNLLDKGMIMHVTCCKGASGSLCLCKERALKSNHRAKRCQDRQKSQKPQKPGQRESEPCQLLLSSKKKNDQLFKGVRRVAKGNRHCHY", "function": "DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.", "AFDB_id": "AF-Q9QYL0-F1-model_v4" }, { "swissprot_id": "Q9ZW82", "sequence": "MRAAINRANSLGGLFSFRFIRNIKSMSSSTSQDFVSRPVIKKVFAKLQKEGDGAVVRRGISRSEQKLLDPFLMLDEFSVSPPAGFPDHPHRGFETVTYVLEGGITHQDFKGHKGTIYAGDVQWMTAGRGIIHSEMPEEEVNKGLQLWINLSSNEKMIEPNYQELSHSDIPKAEQNGVEVKVIAGESMGIQSPVYTRTPTMFLDFTLQPGAQIHQNVPESWNAFAYILESGEGGGVFSSSNSSPIPAHSVVVFGPGNDGVSVWNKSSSKQLRFVLIAGEPIGEPVVQYGPFVMNTQAEIDMTIEDYHYGKNGFEMAKYWRSQ", "function": "Involved in susceptibility to the bacterial plant pathogen Ralstonia solanacearum. Stabilizes the xylem cysteine protease XCP2 by blocking its autolysis.", "AFDB_id": "AF-Q9ZW82-F1-model_v4" }, { "swissprot_id": "Q86M34", "sequence": "MIVLLLLISYCFAGNGVNVKNQLLLMPYPTTVNAQFGSNDCVEATSNIKMVLSNNCQNDPNCLSFMTFNFNHTITYPLQRQRNLEDFRVSIFAPIDIEEMKGNVVYSANTVNIELTGNNIEEIYPPLKIGIDESYSLDVTKEGIKISATTVYGARLGLETLIQMLRPYQGKYIIKHIPIMIEDKPRLQWRGLMIDVARNSFSRSAFVKIINAMAAIKANVLHIHLSDAQTFMFESKEYPELSKKGAFFQNKVLTQSFIKQLVQYGAKRGVIVYPEIDTPAHTASWNAGYPGVVADIWDYIVSSSMRYGENVLALNPANEKTFSIIDALMKEMGEVFGNDYVHFGGDEVWTGAWSKAKEYPAILEWMNKKGINTLKELEAYFNKYAQEQIIKNGKTPVCWEEVYQKGSADKKTIIQVWNNVNLLKEAATAGYKVILSAGYYLDMQMPLCSDYVADSCTNPNHMWVWTNRDMYRNDPIKELDYATKQNVLGGEACSWDESVDEQNFFDRVFQRFSAVAERFWSSEDITDPESHEVRANYVRCLGLRRNFLKGTGPLYHSYCQLPEDI", "function": "Hexoaminidase complex may contribute to amoebic pathogenicity and may be involved in the destruction of extracellular matrix components.", "AFDB_id": "AF-Q86M34-F1-model_v4" }, { "swissprot_id": "Q96ER9", "sequence": "MMGRSPGFAMQHIVGVPHVLVRRGLLGRDLFMTRTLCSPGPSQPGEKRPEEVALGLHHRLPALGRALGHSIQQRATSTAKTWWDRYEEFVGLNEVREAQGKVTEAEKVFMVARGLVREAREDLEVHQAKLKEVRDRLDRVSREDSQYLELATLEHRMLQEEKRLRTAYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPVSLQEAIREQASSYSRQQRDLHNLMVDLRGLVHAAGPGQDSGSQAGSPPTRDRDVDVLSAALKEQLSHSRQVHSCLEGLREQLDGLEKTCSQMAGVVQLVKSAAHPGLVEPADGAMPSFLLEQGSMILALSDTEQRLEAQVNRNTIYSTLVTCVTFVATLPVLYMLFKAS", "function": "Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume.", "AFDB_id": "AF-Q96ER9-F1-model_v4" }, { "swissprot_id": "Q886M6", "sequence": "MTTSTPNGHDLPARLLQALAPWRTASTWYVGFSGGLDSTVLLHLLAELAKRANLPALHAIHVHHGLQAIADAWPEHCRQVCQALGVAFESVRVKVEPGASVEQAARQARYAAFTERLGEGDVLLTGQHRDDQAETLLFRLLRGAGVRGLAAMPEQRRLGRGHLARPLLGVSRVELESYARRQGLRWVEDPSNDDQQFSRNFLRSQVLPLLTSIWPHATASLARTAGHLGEAQQLLDELAAQDVANAQATTPFSWLGLPVLNLGPIARLSGARQRNVMRHWLAPLTRLPDSDHWAGWEALRDAAQDARPLWRLADGALHRAQGCIWWLPAGWEQACSEAVNWADPRAPLDLPENGQVSLEGEAPLGDLSVRYRQGAEVMHLSGRGRRDLKRLLNEQAVPAFLRGRWPLLYRDDELLAVANLPGLDGSPNERWRLRWVAPTGDQSLS", "function": "Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.", "AFDB_id": "AF-Q886M6-F1-model_v4" }, { "swissprot_id": "Q9CWU0", "sequence": "MFEVLVLKIEDPGCFWVIIKGCSHFLEQEVDYQKLNTAMNDFYNSMCQDVEMKPLMLEEGQVCVVYCQELKCWCRALIKSIISSADHYLAECFLVDFAKYIPVKSKNIRVAVESFMQLPYRAKKFRLYGTKPVTLHIDFCEDNAEIVPATKWDSAAIQYFQNLLRATTQVEAKLCAVEEDTFEVYLYATIKNEKVCVNDDLVAKNFAYYVSPMGNKNLNPLEKPRQSLNSVTCSSKLSPSLTLWPMLLQGKDYHRMENKALNYKDSLTDSPKMMLEKQQQSLPLKHTEKCTESSVYWPTKRGITIYADPDVPSVSGSSQRPNEKPLRLTEKKDCDEKNGCVKLLQFLNPDPLRADGTSDLHQLQKVKLGTLQPGVVLRNRIEPCLTLEKSPLSADLKKMALTCLNSDTEDMKVAMEEMIPPEALQRNKFPGPSHTASYSWPPIARGCDMVVISHCGNDPLLYLPPLLTILQMGGCYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSMSSRPLHPVLLTIGLHKDEAKNMKLPRGCDVIVTTPHSLLRLLTYRSLLFLRLCHLVLDEVHMLFFEANEQMFAILDNFKKNVEVEERESAPHQIVAVGVHWNKHIDHLVREFMKDPCVVITALEEAALYGSVQQVVHLCLECEKTSTLLQVLDFVPSQAQKTLIFTCSVAETETVCKGSPAEQGDKKTKSVLLLTERNASHAVGILRYLERADAKIPSELYEFTAGVLEAKEDKKARRPLCPYLKAFGFCKDKRICPDRHHINPEMDIPRKLSNKTLPVFGHIRVIPFYISNATNYFGRIIDKHVDLYETLNAEMNEYFKESSNKTSAEKVENLGLYGLEEKTLFQRVQVLEVSQKEDTWGLGSILVKLIDEGRTKLITRDQLLLLPEKFHTLPPQAVEFIVCRVKPADSEIEWNPKVTRYIHHKIVGKMHDAKVVLALGNTLWIDPMVHVTKLSNLKTSIIDYNVRAEILSMGMGIDNSEHLEQLKKLYKEAKLPAFEDLPCQTSIPTTVEDTVCLQGTQQGDGGTERGAGSQEDSDNQKPGVLSEDIGSETISSAPQPHGRSFHPQIKWFQKDDVVILKIKIRNVKDYKCKFFTDRVIFSAWVGDKFYLADLELQGDIRKDDCKCIIKDDEPLITLAKEKQECWCGLLKQRNPNVAFDFDHWEECEEDSPFSKVVNSKNLSCKVAALAESSGSSSDTTDGSESE", "function": "Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.", "AFDB_id": "AF-Q9CWU0-F1-model_v4" }, { "swissprot_id": "Q9SRR2", "sequence": "MDGLCYVIFIIFSLLSCAFSPLSYASPATFSRRHLLQAPVTDPSTFSPPFFPLYSSTSPPPPPSPPQPLPPPAPTFATFPANISALVLPRSPKPQTPSRTLLIPAISAVLAAATLIALAFFFYGRWRGQTSHFKDESKSLASDISQSQQQTLPCPPPRNNNTQNKLSVAPSTSDVLYLGNVVTSSGSGFVKPESPDISPLPPLPARSFLLQHHSEANLDEEEEDDDFYSPLASIAGQESRDRRINPYSNCSCSISSHSDSPAMSPSAAMSPPMNSTAPHWSTNQNTHSPSSPERTVRNNKRYGGQSLRMFSLWNQNLGFPRISSASTSPERGMIRTPDAYARSSMYSSVSTTPDRFFRKVLDSSPPRWNDFSRNVKSLFLSSTSASPARDFCINISESSRSLKSSWEKPELDTTQQRESAAAAVTLPPPQRPPPAMPEPPPLVPPSQSFMVQKSGKKLSFSELPQSCGEGTTDRPKPKLKPLPWDKVRPSSRRTNTWDRLPYNSSNANSKQRSLSCDLPMLNQESKVLDPRKSQNVAVLLTTLKLTTNDVCQALRDGHYDALGVELLESLARVAPSEEEEKKLISYSDDSVIKLAPSERFLKELLNVPFVFKRVDALLSVASFDSKVKHLKRSFSVIQAACEALRNSRMLLRLVGATLEAGMKSGNAHDFKLEALLGLVDIKSSDGRTSILDSVVQKITESEGIKGLQVVRNLSSVLNDAKKSAELDYGVVRMNVSKLYEEVQKISEVLRLCEETGHSEEHQWWKFRESVTRFLETAAEEIKKIEREEGSTLFAVKKITEYFHVDPAKEEAQLLKVFVIVRDFLKILEGVCKKMEVTSSLA", "function": "Might be involved in the organization and polarity of the actin cytoskeleton.", "AFDB_id": "AF-Q9SRR2-F1-model_v4" }, { "swissprot_id": "P0AAT4", "sequence": "MQDLISQVEDLAGIEIDHTTSMVMIFGIIFLTAVVVHIILHWVVLRTFEKRAIASSRLWLQIITQNKLFHRLAFTLQGIIVNIQAVFWLQKGTEAADILTTCAQLWIMMYALLSVFSLLDVILNLAQKFPAASQLPLKGIFQGIKLIGAILVGILMISLLIGQSPAILISGLGAMAAVLMLVFKDPILGLVAGIQLSANDMLKLGDWLEMPKYGADGAVIDIGLTTVKVRNWDNTITTIPTWSLVSDSFKNWSGMSASGGRRIKRSISIDVTSIRFLDEDEMQRLNKAHLLKPYLTSRHQEINEWNRQQGSTESVLNLRRMTNIGTFRAYLNEYLRNHPRIRKDMTLMVRQLAPGDNGLPLEIYAFTNTVVWLEYESIQADIFDHIFAIVEEFGLRLHQSPTGNDIRSLAGAFKQ", "function": "Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks.", "AFDB_id": "AF-P0AAT4-F1-model_v4" }, { "swissprot_id": "O88917", "sequence": "MARLAAALWSLCVTTVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLAFPNPYQFVSSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPAPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKQNVVLEVTVLSTEGQVQELVFPQEYASESSIQLSANTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGTGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQYEVACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGAHGSLKTSAMRSNTRYYTGTQVPGQGRHIHQVSLGPRGRSALPESQKDPGGQSGPGDPLTFGLCPSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGASGGAKGPPPEPPVPPVPGVSEDEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPNEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAAPSLEGPGPDGDGQMQLVTSL", "function": "Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization.", "AFDB_id": "AF-O88917-F1-model_v4" }, { "swissprot_id": "Q10241", "sequence": "MRLFDAMPPYLTYQAPLSLIIFHKMVFAIRIRQFHTTLVSAEKNGLQKLIPPRLKTIWNQMLVETKGAGNGPERFEMIRQKYKALTADEIQKYKNKLQEQFDAEKKRFMETLRSFTPTEIDSENRRRSKEAHSTGSRYYRLRHPDVPKKPSSAFILFYKELRNNPKLRQELGIPEAISTLVEETQNASKAWKELAEDKKKPFIDKSKALKEQYDKFMKEAGFR", "function": "Binds to cytosines in base mismatches and opposite chemically altered guanines.", "AFDB_id": "AF-Q10241-F1-model_v4" }, { "swissprot_id": "Q9LPL6", "sequence": "MANNAAACAERATNDMLIGPDWAINIELCDIINMEPSQAKEAVKVLKKRLGSKNSKVQILALYALETLSKNCGESVYQLIVDRDILPDMVKIVKKKPDLTVREKILSLLDTWQEAFGGSGGRFPQYYNAYNELRSAGIEFPPRTESSVPFFTPPQTQPIVAQATASDEDAAIQASLQSDDASALSMEEIQSAQGSVDVLTDMLGALDPSHPEGLKEELIVDLVEQCRTYQRRVMALVNTTSDEELMCQGLALNDNLQRVLQHHDDKAKGNSVPATAPTPIPLVSINHDDDDDESDDDFLQLAHRSKRESARGTGQGNFNPILPPPPSSMRPVHVDSGAMDFLSGDVYKPQETFENVKPPSTSQSSNHDYSAPIFDEPVPQSKSPEHALFTKPVYDQTEQLPPAPWETQEPRKYPPSMSARTNKRPEYFQHNVPQHSSSASESSYDDLLGQSRNLSLNPTASAAPVTPPKKDDKPEDILFKDLMDFAKTRTSSSSSSKPNNQNNKPF", "function": "Might contribute to the loading of the ESCRT machinery.", "AFDB_id": "AF-Q9LPL6-F1-model_v4" }, { "swissprot_id": "Q54K81", "sequence": "MSLTLKIQIVRDKQVKAMKFSPTQTVAEVCAQVREKINETSGDDHGLFQPGIDAKRPSRWLKMDKTLQFYDLKINDELDYKKKHRPLKVRLMDETVKTMLVDDSLTAGEILEIIGKRIGIKNYEEFSLQTEGAAAGEWINHAQPLHEQGVPDDAVVLLKKKFFVDDFNVNRDDPIQLHLVYVQSRDAIISGSHPCSYEEAVQFGALQCQIQLGNHNPNLHKPGYLKIKEYFPPSFHKKKDAEKDIYKEFRKLTGMSESNSKFRYVQLCRSLKTYGITFFLTKERVKGQKKPVPKLLGITRDSILRLDAETKEVEHEYPLNHLRRWAASPQSFTLDFGDYEDDYVSVITTEGEAISQLLSGYIEILMKKRKDTGTVIDENETDIANVESVGRIRGQTSQATTSSSLSGYDGNGGREGQYSAPGQAIGYRGGLGGPLSIKVTNIDSASAAVANLLNEMELDPNAVIGQKSSLTPQQWRQQLAIHAKAVAAAAGKLLGNLNNPNGMDKNQMDSNARDVALTIDQLVHAARAASIASGEDPDGEMPLFDGAKAVAESISKLLKATKDLSSNPNDENARNLIAQAADQLKLMTSYLDGACNGVITDSGTLRLLMEAGKAIAIATQDLVNQANVAIQDINDPIRKNQLNMAIDETMKAGIHASAVSQALAATILDPNCRQQFNTAAKTAQDTNNYLLSAAKAAQMDPALLEKLRASAKSIAEAYASLIQSADLAQPKSGDDVEFTSASKTILSAAAQLLGSQGKSDNIMQQAKVIEEAMGHLIAGARRAALKTDDPGVRDRLIQCSKAVAEAVRNLMEIAQDSADNPEDKVLFAKLQESSKRVATAVKQLVGDAGKESAFQLLRTNAKLACAATTGLMNTSRQSMLQGHLSDQESNKLLLACVQAGPAITNLLNSITSSQKAPNDLPAQNQLIEVARVSAPIAYQVVAVAKGAIPHFTDQHSKQEVSNSSNTASDAIRALLDAIGDLTSAVGQQEFDDALDTVQALEADMESSTMLVQAGTTHQIPGQTRENALELLNVAARALGSSAKQVLLQYKTSPEKLGETSKDLATSVSQVTNAAKSVCFTTQNRSVQKAVLGAAKQITTESTNLVSCARAVSSNPGDPSLESALQSSVKAIAEALANLLTTSKGGDPGGKDLDDAIEAIKNDTKRINNPPVNLGGEGGVNSEKAISSSKALVGAVSQVAANARSNPSALGASARTTSTTFTLLVDTINLCTGTIVNKQLAIEIVKGGQLLGIETIKLLQASRFAASRPGEGEGELNQTQQSVSNTVKQLIYNIQSSVPGQAEIADALEIVKQAIIALNSSESSGSRPNALESLTQAAKNLADYTAQVVQSKGNSEKMGTQCKSASESLKDVVEYTKASLSTAEGHPDSIKTLASKVDDSSNALFNSCKKTGQLSDQDKKNAALDAKNLALSVPNLMGAAKKISASLVQSNPEKSKDILLVAQNITIATSKLVNIAKSVASGQSQADVSQLAATKKEVSELISKLLNATNGHDQDATTISIDLDSLSKSEQALLDASRSTANYMSQFMAIGKTISTGTKDPNVHQQFSGAAQNVSSGVQQLLSAINGMKPEQKDLDESIEIIQNAVVDLDSATLNAAIGLLENTAPVGKTAQVCQEELVDISRELATSMKTFLAAPKQDPTNLGQSAKDTANILPKIVNISKQLASLTTNPDIKQTQLLLSKKLADNMLELMISAKSGDVSDSKQAFNASQSIADILTSVKGGVMQSRDCDESIQIIGKSKENLQKPANDTHGKTYQQYRDEMTEIAKQLALGVSQLANSAKSKPEEIGSSSLKIASIIPRLAETARSTAAATNDVAAKKKLIDSTTGIIDATSNIISDAKLASADHKNTQLQQKISNNFKDITTQIANLIAALRAGATADRDIENACNEVNHVTTDLDAASLFAAAGQIDIDTDGHTTQNIQEQVGKLAQDLKDSKNQLAEASGKTIEDVGTSAKATASINQKLAHATKVCAALTSDSTTQQNLLSAARTVSSNLQQTISASKNAQKNPNAGNKAILDKSSQELEESIDSLANLVQSSTTTKGISELEGVSSEIRKQLAAYDSATANVNANATAEDVVNSAKNLAESIAYLVSSCNNSPEDIAEASKGTTLAIKSLLANAKGASVLTDDAVIQQNVTESAKAAAQTVLKLIQAAKQQRNDPSNPAHQNKLSEISSEVVESISTCVNAAEDLPEGKRAKLLFAAGESLEETAEKELKAAAAIIEEATAALLNAKKKREQNRIASGIDEAGIDESILEAARAITSATGVLVQCATNVQHELVLAGKVGNKGNMYRRDPTWARGLISAAQAVAGSVQGLVHSANSSSQGKVDEEQLVASAKGVAAATARLVTASRAKADLNSASNSQLAQAAKQVSNATAALVEAAKQVNEEPEVEFDTTNLSNAQIISKEMDQQIQILKLKKELEQAEKKLFSIRKKEYSDQTGNPSPAKDSDNKPTTSISVGITPTKRTTQASPPSPPLTPTQQAAGTPTLPPRPLMKKPAPSQAPSSPVAPVSAPVSKPSPKPAPKPAAPTAAAPNKTYTLEELKKKPANIDHSNLEIYLSDEEFKAVFNCERSELAAMPTWKRNNIKTKLGLF", "function": "Actin-binding protein required for multicellular morphogenesis. Substrate of pkgB and/or pkbA.", "AFDB_id": "AF-Q54K81-F1-model_v4" }, { "swissprot_id": "Q9P7L2", "sequence": "MATIYACRGFHRVPVKLSPSSTLQEVILSSYKQLGFSDWHNLELLHGDKKVDTSLLLRLSGIINGAKLIVKESATNQSGKSSSSISPQSKKIKVALQLPGAARIIDEASSETSIKQLLERHSLLTKVSHVLINGRNFKSEEFDNPLLLYGIREGSILIRLFPIKAQQSIVSEQAPVSQTFNGDVKEKKNADLMDIESENKKDDIVESFPKYPVDAHKLLEPLPTPIPSLPSTPSSYQNLPSQSLTGESLPTVSNQEKDEGVIEKVAVNNTPSVSSKSPFPKKKSFSSMLAQVKKEKAENNGSDGYDLQPTKSQLELYQSILRKRANQVSSTSLTKSSSPKPLPSSAIVKFDFGNGKSIVHEFSKDDNIETLRAFVASHLSPEESTSFQLTFSNYEALPTTGLIVEHIGRAVVRVHTISDPVYAQR", "function": "Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.", "AFDB_id": "AF-Q9P7L2-F1-model_v4" }, { "swissprot_id": "Q8S6P9", "sequence": "MADCTTMRLASSVTIILLLLVASQALVVSGESSSSAMQSKTLNMNKLLNISEDHSPNGGRHWMQRMQPDSCSEQNVVVYQNNAEHLPSGIPTYSVEIINVCTACTVYDVHISCGEFASAELVDPSQFQRIGFNDCLVKGGGRLGPSEAVSFQYSNSFAYPLAVANVACE", "function": "May play a role during anther development.", "AFDB_id": "AF-Q8S6P9-F1-model_v4" }, { "swissprot_id": "C5M7P6", "sequence": "MSKKKEKKFQESKISTRSYRSTTMLRHQIRRITTANRLLDELKTSKDIEKFLNNSTWSIKELLQQPLTNTTTKEVSSDVVTKMLKLSGLSDSQDIQNIRKSLNLQMMFINHLYDKSGNNAEKKVNDNNCMFRLLASDHIPQRPLDLDTLMDEINKLEPSEEKGEIGFGIKDLQRDSFVINKK", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.", "AFDB_id": "AF-C5M7P6-F1-model_v4" }, { "swissprot_id": "Q7V5B5", "sequence": "MATTLRDILDKLLGRQPASAKTARERLQLVLAHDRSDLSPELLDQMRREIFEVVAKYVEIDLEEGEVSLETEDRMTALVANLPIKRSQAKAVSSQENGASSQEAVSSQESVSTPGAME", "function": "Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.", "AFDB_id": "AF-Q7V5B5-F1-model_v4" }, { "swissprot_id": "Q9C7A8", "sequence": "MAGQTDPHISLFSPQEVEFMAEDELVEIVPNMNMEQLNFISGDFGRFIPQIPTKVPLWLAVALKRRGKCTFRPPGWMSVDNLTQILEAERESQSTFQALPFSYVEIARLLFDHARDDIPDMYMVRSLVEDIRDVRLHKLETNLGSFQGTSAVKISNVSAMEVNIVRPFVIRALEAFYKHDKPEADVDRDTRSSRQQRETNNEPRRPLRQR", "function": "The GINS complex plays an essential role in the initiation of DNA replication.", "AFDB_id": "AF-Q9C7A8-F1-model_v4" }, { "swissprot_id": "Q9JJA2", "sequence": "MAAALPLQPSTTASATTTATAVALGEVEDEGLLASLFRDRFPEAQWREKPDVGRYLRELSGSGLDRLRREPERLAEERAQRLQQTRDLAFANYKTFIRGAECTERIHRLFGDVEASLGRLLDRLPRFQQSCRNFVKEAEEISSSRRMNTLTLNRHTEILEILEIPQLMDTCVRNSYHEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQQLRTNIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEACRVHLFDIITQYRAIFSDEDPLLPPAMGEYTVNEGAIFHGWVLQKISQFLQVLETDLYRGIGGRLDSLLGQCMYFGLSFSRVGADFRGQLAPVFQRVAISTFQKAVEEAVEKFQDEMTSYTLISTAAILGSSNTPATVPATQPGTLQPPMVLLDFPPLACFLNNILVAFNDLRLCCPVALAQDVTGTLENALTKVTKTILAFHRAEEAVFSSGEHEIFVQFCTAFLEDLVPYLNRCLQVLFPPAQIAQTLGISPTQLSKHGNLGHVNISAIQEPLAFILPKRETVFCLDEQELGPDLVAPAPELPAEQRSMEPVTEKREPGEPLPQEPMEGEPLPAEPPSEGGAIGSVPCPQPGEQP", "function": "Required for normal Golgi function.", "AFDB_id": "AF-Q9JJA2-F1-model_v4" }, { "swissprot_id": "P18891", "sequence": "MPTEFLYTSKIAAISWAATGGRQQRVYFQDLNGKIREAQRGGDNPWTGGSSQNVIGEAKLFSPLAAVTWKSAQGIQIRVYCVNKDNILSEFVYDGSKWITGQLGSVGVKVGSNSKLAALQWGGSESAPPNIRVYYQKSNGSGSSIHEYVWSGKWTAGASFGSTVPGTGIGATAIGPGRLRIYYQATDNKIREHCWDSNSWYVGGFSASASAGVSIAAISWGSTPNIRVYWQKGREELYEAAYGGSWNTPGQIKDASRPTPSLPDTFIAANSSGNIDISVFFQASGVSLQQWQWISGKGWSIGAVVPTGTPAGW", "function": "Lectin that specifically binds to L-fucose. Has strongest preference for the alpha-1,6-fucosylated chain (core fucose) on glycoproteins among alpha-1,2-, alpha-1,3-, alpha-1,4-, and alpha-1,6-fucosylated chains. Might play a role in the differentiation of the fruiting body. Exhibits antifungal activity against Mucor racemosus and thus could act as an antifungal protein in natural ecosystems.", "AFDB_id": "AF-P18891-F1-model_v4" }, { "swissprot_id": "O83544", "sequence": "MFRSQRMKFLELVVLERDVDRVLEYLGKTALVHLRLSAAARGSSSHCAQSKEYVGRLEEACKYLGVSGECAFSPGDSLPTEEDYTLAQQILAEVDALHAREREGDAPSVPRGKSSVAHDSANEEQFQGEKCALGSMRGPALCALLRRFALQERVHRTRDALESTRHTYRIAGWLPAHEAKDLVAGLDNVTTGRMAVRLFEPQELSFIRDGSEHVPVCYQHGRFVRSYERMVSSYGCPPYGLVDPTPFVAFSYALLFGIMFGDLGQGLLFFVLGLLLRTRRVRALNRWAHLDYVFLSVGFSSMVMGFLTGEFFAHGTLLAPLIRSVTALCGGVPRDHILHLMPSHGSLHTLMAFFGFTLFLGFVINSLGLIINIVNQVRLRHALQQCVQKRECADSSFFGTWLPLQCAYHFLEFHSGSLMRLQWACLSWVFFVKSFWSVCASVCVRGFLKVLACI", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-O83544-F1-model_v4" }, { "swissprot_id": "O22993", "sequence": "MASIDNVFSLGTRFSIPENPKRSILKHATTSSFSARTQTRWRAPILRRSFTVLCELKTGSSSSGETNNSPAADDFVTRVLKENPSQVEPRYRVGDKLYNLKEREDLSKGTNAATGAFEFIKRKFDSKKKTETDKSEESVYLSDILREYKGKLYVPEQVFGPELSEEEEFEKNVKDLPKMSLEDFRKAMENDKVKLLTSKEVSGVSYTSGYRGFIVDLKEIPGVKSLQRTKWSMKLEVGEAQALLKEYTGPQYEIERHMTSWVGKVADFPNPVASSISSRVMVELGMVTAVIAAAAVVVGGFLASAVFAVTSFAFVTTVYVVWPIAKPFLKLFVGVFLGVLEKSWDYIVDVLADGGIFSRISDFYTFGGVASSLEMLKPILLVVMTMVLLVRFTLSRRPKNFRKWDLWQGIAFSQSKAEARVDGSTGVKFADVAGIDEAVDELQELVKYLKNPDLFDKMGIKPPHGVLLEGPPGCGKTLVAKAIAGEAGVPFYQMAGSEFVEVLVGVGSARIRDLFKRAKVNKPSVIFIDEIDALATRRQGIFKENSDQLYNAATQERETTLNQLLIELDGFDTGKGVIFLGATNRRDLLDPALLRPGRFDRKIRVRPPNAKGRLDILKIHASKVKMSDSVDLSSYASNLPGWSGAKLAQLVQEAALVAVRKTHNSILQSDMDDAVDRLTVGPTRIGLELGHQGQCRRATTEVGVAITSHLLLRYENAKIERCDRVSIIPRGQTLSQVVFHRLDDESYMFGRLPQLLHRLQVLLGGRAAEEVIYGSDTSKASVDYLSDASWLARKILTIWNLENPMVIHGEPPPWRKRPQFVGPRLDFEGSLYDDYDLVEPPVNFNMDDEVAHRSEELISQMYNKTVSLLRQNQTALLKTVKVLLNQKEISGEAIDFILDHYPPQTPLNSLLQEQNPGSLPFVPEHLRRESGDFVLVNHSTDVNAQV", "function": "Functions in chloroplast biogenesis and chloroplast division. Required for plastid development during embryogenesis. Might be involved in chaperone functions or play a structural role in the thylakoid FtsH complex.", "AFDB_id": "AF-O22993-F1-model_v4" }, { "swissprot_id": "C0LGQ9", "sequence": "MNLSRILLLSMFFLSAMGQLPSQDIMALLEFKKGIKHDPTGFVLNSWNDESIDFNGCPSSWNGIVCNGGNVAGVVLDNLGLTADADFSLFSNLTKLVKLSMSNNSLSGVLPNDLGSFKSLQFLDLSDNLFSSSLPKEIGRSVSLRNLSLSGNNFSGEIPESMGGLISLQSLDMSSNSLSGPLPKSLTRLNDLLYLNLSSNGFTGKMPRGFELISSLEVLDLHGNSIDGNLDGEFFLLTNASYVDISGNRLVTTSGKLLPGVSESIKHLNLSHNQLEGSLTSGFQLFQNLKVLDLSYNMLSGELPGFNYVYDLEVLKLSNNRFSGSLPNNLLKGDSLLLTTLDLSGNNLSGPVSSIMSTTLHTLDLSSNSLTGELPLLTGGCVLLDLSNNQFEGNLTRWSKWENIEYLDLSQNHFTGSFPDATPQLLRANHLNLSYNKLTGSLPERIPTHYPKLRVLDISSNSLEGPIPGALLSMPTLEEIHLQNNGMTGNIGPLPSSGSRIRLLDLSHNRFDGDLPGVFGSLTNLQVLNLAANNLSGSLPSSMNDIVSLSSLDVSQNHFTGPLPSNLSSNIMAFNVSYNDLSGTVPENLKNFPPPSFYPGNSKLVLPAGSPGSSASEASKNKSTNKLVKVVIIVSCAVALIILILVAILLFCICKSRRREERSITGKETNRRAQTIPSGSGGGMVVSAEDLVASRKGSSSEILSPDEKLAVATGFSPSKTSNLSWSPGSGDSFPADQQLARLDVRSPDRLVGELHFLDDSIKLTPEELSRAPAEVLGRSSHGTSYRATLDNGVFLTVKWLREGVAKQRKEFAKEVKKFSNIRHPNVVTLRGYYWGPTQHEKLILSDYISPGSLASFLYDRPGRKGPPLAWTQRLKIAVDVARGLNYLHFDRAVPHGNLKATNILLDGAELNARVADYCLHRLMTQAGTVEQILDAGILGYRAPELAASRKPLPSFKSDVYAFGVILLEILTGRCAGDVITGEQEGVDLTDWVRLRVAEGRGAECFDSVLTQEMGSDPVTEKGMKEVLGIALRCIRSVSERPGIKTIYEDLSSI", "function": "Receptor kinase acting as an early component in abscisic acid (ABA) signaling. Required for darkness, ABA, high CO(2) and hydrogen peroxide (H(2)O(2)) induction of S-type anion currents in guard cells leading to stomatal closure, possibly via the phosphorylation and activation of the anion channel SLAC1 and as a scaffolding component. Seems to act in parallel with SRK2E/OST1 in the ABA signaling pathway which regulates stomatal movement. Binds ATP. Involved in the local and/or systemic stomatal responses (e.g. stomatal closure) to light stress.", "AFDB_id": "AF-C0LGQ9-F1-model_v4" }, { "swissprot_id": "B2HGX7", "sequence": "MIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLAAGVTWSASLVFGPVSPLPGLLAVAVLLLATRGLHIDAVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAVQGSAFSTLSAAGSRGIAGIAVAVFAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVLVAWLAVLLFASLAAAPRPWQGPAAVVAAVCAGTLLIRHCVRRFGGITGDVLGCAIELATTVTAVVLAALVRL", "function": "Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.", "AFDB_id": "AF-B2HGX7-F1-model_v4" }, { "swissprot_id": "O94614", "sequence": "MDSASSMRNRSPLGVPEFSYSSQSVNNIRGIKSRNRSSIGHSITDPQVASRINAFYLSNVQSSIPFETDAIGPAYGIGDMIAPEMNDTQSLSASVTNMKKENFYSRPNVSSSSILLTIKRATSSQETKRDRPLPNIRNSAPSATRSHSTPCVAPGYLRTSNEAADVVFPHEEAHFSNHNPKPNNGSPLQKQVVADLPFPLPVSDEEQLDWIRANEDLVHSQDIDEALEWAEYVLRFTQSHLPYLQTYESENLHEINYLESMCENALYKIREFSELENAKAMYFDAYVYETGAFDVESDIQRAWDLYSSSANLGYTRSLYRLGVLLEDQGNLEEAVEYFEKGVSENDSACCWRLSLLILEGMLDGVGEYAHRHASGLELLERSADTADADVPSGLYSHALVNLHEHPGLVDLGSENIRVPIDEATALKSFAKAAFLGHSSAQLRMGAVYEFGKYGCPVVPRYSLFYYSAAAKRGETEADLAVAKWYLNGSDGIPVDEDLAFMHAERASMAGNANAQFLMGYLFDTRGNTEQATYWYNEAAKAGHSEAIERLALLENQIQEPEPENITSSQYPNQDVIKEIPVTASETSPPHAPAVSSTPVTSAPPVSQTKVTKVSVPKKTSKKFLIKHNKCIIS", "function": "Involved in septum formation. Required for the proper localization of chs2 at the septum.", "AFDB_id": "AF-O94614-F1-model_v4" }, { "swissprot_id": "P51566", "sequence": "MQSSVYRDKASSIAMILETQRNVEFPHRIVDKRPRKRPRLTWDAAPPLLPPPPPPTVFQPPLYYGPEFASGLVPNFVYPNMFYNGLPRQGSPPWRPDDKDGHYVFVVGDTLTPRYQILSKMGEGTFGQVLECFDNKNKEVVAIKVIRSINKYREAAMIEIDVLQRLTRHDVGGSRCVQIRNWFDYRNHICIVFEKLGPSLYDFLRKNSYRSFPIDLVRELGRQLLESVAYMHDLRLIHTDLKPENILLVSSEYIKIPDYKFLSRPTKDGSYFKNLPKSSAIKLIDFGSTTFEHQDHNYIVSTRHYRAPEVILGVGWNYPCDLWSIGCILVELCSGEALFQTHENLEHLAMMERVLGPLPPHMVLRADRRSEKYFRRGAKLDWPEGATSRDSLKAVWKLPRLPNLIMQHVDHSAGDLIDLLQGLLRYDPTERFKAREALNHPFFTRSREQSIPPFNPNPHPFLYNQKN", "function": "Activator of yeast transcription factor, STE12.", "AFDB_id": "AF-P51566-F1-model_v4" }, { "swissprot_id": "O46028", "sequence": "MEGIAKITLILLFLFVTMHTFANWNTEAAVCVYRTCDKDCKRRGYRSGKCINNACKCYPYGK", "function": "Blocks Shaker B (Sh) and voltage-gated potassium-channels Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3. Also inhibits small conductance calcium-activated potassium channels (KCNN) and intermediate conductance calcium-activated potassium channel (KCa3.1/KCNN4).", "AFDB_id": "AF-O46028-F1-model_v4" }, { "swissprot_id": "Q7SB97", "sequence": "MSLFGSSPPNDGSAALNPAKTANSSRSTLFDNEAPTTRSGSALFADDDHDSPWDMPTPRKQRSRADLIRNLLPSGDVPESYIETFDAVVRTENRSTNGRITAGGVARTLAAAKLGADDQARIMGIIAPASASATGAGGGGDGAHGGEANSSAAAAAAAVGLGDLGRNEFNVLLALIGLVQEGEVASLDGVDERRRNLPQPKLQGLVNENVQPMLPNLSELGAKPPQRPVTPPKAPTPSPPKQQQQQQHQPPTLRKVSMEYPEDPWNAPDLHKGHNHGPLEHSTGHNGAADVPRSVANDLNGNDAVSYSTSPEVTTTSSALPGRTTSTFTTSQPPSGPSSIHNVAESIQESNGAWNYFPGSSSGGGFGEPADNAITGPFGDSGGPGQSVSGSVGGSNPNRSIGHVRSGSNVEENILVTLMPEKEGVFMFQHHNYEVSSIRRGSKVVRRYSDFVWLLDCLHKRYPFRVLPLLPPKRVAFNGNHLSNDGAFIEKRRRGLARFLNALVRHPVLGQEQLVIMFLTVPTELSVWRKQATISVQDEFTGRTLPPGLEDSLPPTLEELFARTRVGVRRSAELYISTCTIMDRLIKRSEGVAADHARMAVSLISLTETSADTYATDHNDVPLLNDGLQAMGRHLRTAQTLMEDEAKAWEEGVLEDLKRQRDALVSLRDMFDRRDRLDKDNIPFLQRRIETNEAKLQALNAKPEGMVKPGEKERVVEAIIKDKESIVTQHNRSVFVKECIRDELRFFQNTQYNVSRLTQDWAQERVKYSEMLADNWRRLLDDLEGMPLGD", "function": "Required for vacuolar protein sorting.", "AFDB_id": "AF-Q7SB97-F1-model_v4" }, { "swissprot_id": "O13911", "sequence": "MSSKKRKSPPQESLTSYFEKSSKSSKKYGSQNKDSDSSSTCLQQKIEIQWSITDSLYIAKYGKLKKTKKFIAFDLDGTLIKTKSGRVFSKDAADWTWWHPSVVPKLKALYQDNYSLVIFSNQNGIPRKPSAGHTFQMKIRAIFESLDLPIVLYAAILKDKFRKPLTGMWNSFLKDVNRSIDLSFIKYVGDAAGRPGDHNSTDLKFAENIGIKFETPEQFFLGHSFVPPNFESFHPKNYLVRNSSSHPYHFKKSEHQEIVVLVGFPSSGKSTLAESQIVTQGYERVNQDILKTKSKCIKAAIEALKKEKSVVIDNTNPTIESRKMWIDIAQEFEIPIRCIHLQSSEELARHNNVFRYIHHNQKQLPEIAFNSFKSRFQMPTVEEGFTNVEEVPFKCLKDYEDTWNYWYE", "function": "Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA.", "AFDB_id": "AF-O13911-F1-model_v4" }, { "swissprot_id": "Q6BLT3", "sequence": "MPPIYVKGGVWTNVEDEILKAAVSKYGLNQWSRVASLLAKKSAKQAKARWNEWLNPNIDKSEWTREEDEKLLSLAKLLPNQWRSIAPIIGRTATHCVERYQKLLEDTNDVGIEGDENDLRLSGPGIESLPATGTSHVGDLNINPESKPAKPDEEDMDDEEKEMLSEARARLANTQGKKAKRKARERMLEESKRISLLQKRRELKAAGMKVSLESKNKKRRQEFDYNADIPHEHEPQSGLYDVDEENEANRLERIKFERGVAKEGIPLQEVDEKHKKQKQEAKKSKDDGAKQTQMSLEAAAEVFHEREQEILKRRKLDLPAPEISLDTQPPIGESGSINISDITTKDSNQEGIDDRILKATRELKRNQATKSSLLAEDTPEIKKETLSKEPTSSKLKSQWKKSVLNLLKSYFAKLPKPHNDIGIILPSYDPNEEPITASNEMSTDSRVDQGERLRNLEILRQVDEEKAKLRRSQAVQRELPIPKPSSLQQIDTSKCSKLDLLIFNEMRTLLNSDYAKYEDPTFKTNLIDDLDEESFGIVNNEISGELMKMESAKVSPKSSHLPKTYEMAEQIISKLHELSSESSSIENSISANINISAFNYRENNALQNIDNLYNELNRADIELKGYTKMLQNEEISIESRSKYLHELVDDLVDNEHLLEEKVRMLRRT", "function": "Involved in pre-mRNA splicing and cell cycle control.", "AFDB_id": "AF-Q6BLT3-F1-model_v4" }, { "swissprot_id": "Q5JDJ7", "sequence": "MKGYLTFVLHTHIPYVRKHGKWPFGEEWVFEAISETYIPLLMEFERLRDSGVKFGIVINVTPVLAEQLTDEYMKKAFEEYMERKLKAMEEDLKSGKYDEKAVSYMLNYFRKVYDYWKAINGDIIGKLRELQDQGYVEVITSAATHGYLPLLGRDEAIRAQIANGVATYEKHFGMKPKGIWLPECAYRPAGEWELPGGRKVKRQGIEKFLEEFGLRYFFVESRLIDEGPASNVYGEVLIADTEKTTLRPYWIKGSNVAVFARNRETGHQVWSAHYGYPGDFWYREFHKKAPKSGGQYWRITSKEVGLGEKEFYDPDKAMERVEEHARHFVSLVERLLREHEEKFGEKGIIVAPYDTELFGHWWFEGVKWLGRVLELLYQRGVETPTLSRFLEEYSGEKHEIELPEGSWGANSDHSTWWNEETEWTWPHIYRAEDRMVAIVSRFRGRDELTNRVIEQLARELLILEASDWQFLITTGQAKEYAKRRVLIHSRDFHRLANELVRYVKIGEFDVKLLEELEERDNPFRPVVVGPYVSENPPELEEYVEPPEVPPEKEETEEKPKVLTEKATSLALAVKKVKPVKEETREVKKKAVEASKRGKRKSSKSKRLPRKVSKKAPSKGPSDLLSIKGIGPKTFQKLKRAGVETIEDLKNANIEDLARKTGISTKRLKKFIAQVE", "function": "Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position. The branch chain-length distribution of the reaction products shows degree of polymerization (DP) of 5 to 30, with two local maxima at DP 6 and DP 11. Exhibits an alpha-retaining catalytic mechanism. Does not display alpha-galactosidase or pullulanase activity, since melibiose and pullulan are not substrates. Is not able to catalyze the hydrolysis or transglycosylation of maltoheptaose, suggesting that the TK1436 protein contains neither alpha-amylase nor 4-alpha-glucanotransferase activity.", "AFDB_id": "AF-Q5JDJ7-F1-model_v4" }, { "swissprot_id": "A4IIF2", "sequence": "MNKVRPRYIIDRPAYSVELFNEEYEKKIRSYPIGGKARKLFSCSTSKIKNFIFRLFPILSWLPKYNIKGNLLNDALGGISAGTIQIPQGMAFALLANLPPVNGLYSSFFPLVVYFFMGGIPQMVPGTFAVISIIVGNVCLKLAPESHFQNVTSNGTITNIEAMNTARMHISATLACLTAIIQIALSFVQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGVSIPPYSGVLAIIYTFIDICKELPKTNVASLIFALISTVLLIIVKELNMKFMHKIRFPIPMEIIIVIVATAVSGSFKLPERYHMNVVGHIPLGFPSPTVPNVTQWDEMVGTAFSLAIVGYVINLAMGRTLGAKHGFDVDANQEMLALGSGNFFGSFFFIHVICCALSVTLAVDGAGGKSQIASFFVMMSVMVTILALGTYLNPLPKSVLGALIAVNLKNSLKQLSDPFYLWKKSKLDCLVWLVSFFSTFILGLPYGLAVGVAFSILVVIFNTQFRNGSSLNQVTATDIYVNPKVYSKVQPIDGIKIVTYCSPLYFANSEIFRQKVIKKTGLDPGKVYLSKKKYLKQQEQELKKKEQKKKRGSLFMKNKTLSLQELQEDFDGVSPTDSNNNSTVNGTASAISYISSNTLTSGSQTTENVQNGFSTPAQTQDPIIAAPPIVNFHTVIIDMSGVCFVDLMGIKALGKLCTSFQRIGVNVYLADVQAQVYDDIENGGMFAEGSLDRKHLFITVHDAVLYAEANNTGIVNTDSKKKGAGDTEIYITDTQDEISEDYPNLEEAMFGSMFQTEIQTAL", "function": "DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. May prefer chloride anions and mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane.", "AFDB_id": "AF-A4IIF2-F1-model_v4" }, { "swissprot_id": "P07256", "sequence": "MLRTVTSKTVSNQFKRSLATAVATPKAEVTQLSNGIVVATEHNPSAHTASVGVVFGSGAANENPYNNGVSNLWKNIFLSKENSAVAAKEGLALSSNISRDFQSYIVSSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLKQVQDFEENDHPNRVLEHLHSTAFQNTPLSLPTRGTLESLENLVVADLESFANNHFLNSNAVVVGTGNIKHEDLVNSIESKNLSLQTGTKPVLKKKAAFLGSEVRLRDDTLPKAWISLAVEGEPVNSPNYFVAKLAAQIFGSYNAFEPASRLQGIKLLDNIQEYQLCDNFNHFSLSYKDSGLWGFSTATRNVTMIDDLIHFTLKQWNRLTISVTDTEVERAKSLLKLQLGQLYESGNPVNDANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKRLWDQDIAIAGTGQIEGLLDYMRIRSDMSMMRW", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.", "AFDB_id": "AF-P07256-F1-model_v4" }, { "swissprot_id": "P52569", "sequence": "MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF", "function": "Functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine).", "AFDB_id": "AF-P52569-F1-model_v4" }, { "swissprot_id": "Q8ZVA7", "sequence": "MRVVYSVEEVEIPKGVSVSIERTGPFDYIVKVKGPLGEVTKEFKNTPVVMSLQDGKIVMEVFKARKREYAILGTYKGILKNMFLGVTRGWRYKLKVIYTHFPMLVKVQGNQLVIENFLGRKSKITLNIPKGVKVEVKGKEDIVIEGIDRELVSTFAAAVQAATELHGDERPSPHGREGGLGVVDGIYVVGYEHIKS", "function": "This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.", "AFDB_id": "AF-Q8ZVA7-F1-model_v4" }, { "swissprot_id": "Q10109", "sequence": "MDNWEDPNFELRNLRVIDLKKILHESGVSFPVNARKIEYIRMVDRIRKNKLSSGPQHLLSHLQKEENSNTSKASSSEDEIAPKYLYPSSPSKSTKKPHNETEPLLSPQFIDKPSNIETPVKIESPHVSQNNTFQSYSELSPNVETSLTMKTPPAHASTPKFRSHKSHRVAVPMSFMDSSALHTSPAFSERLKLLSSSNNFSPQLRSPKISHRLQTSATSSPLQHKRPFTNVPERVSRDIEFAPLDSARPSESSSPYSEVDSAEEDDELFQNYVLQQTRKESKLWSFIKKVFHDIKYANYRLLHNLRAFPGISAISSSYLVHIFMILLGVVAAIFLALLREKMFTAGFCDSGASGSSASILGISFPSLCRTCPPNAICPSPNYVECKPGYVLYEPWYSSLGFWPSKYCVSDTSREESVNIFREECLSVLRSWNAILHCSNNSSDLLERNMSYNAHPYVADNLNISSDHISFPSKPFALGLLHDTLLERKSPTLGLEMFEDLFKASLAVLSETNEVVMDSKLICYDSWAGIPLRCRLKQQLIKFVWRNKVFLFGILALSGVIFKLINFFRTRSIVAKYLPSASRFCVESLKRQKANYQMSRSQEPVIPLIEMHDILFHGNGPLEQIHMTKATARTLWEAIVERVEQVGSVRTRESEVDGEWTRVWEWVGTNTLDFQTDRSFINTTSPLRE", "function": "Nucleus inner membrane protein involved in meiosis. Plays a role in regulating nuclear envelope (NE) morphology and nuclear integrity, particularly during spindle pole body (SPB) extrusion or insertion through the NE, and perhaps during karyokinesis.", "AFDB_id": "AF-Q10109-F1-model_v4" }, { "swissprot_id": "Q5A4X5", "sequence": "MSSLQQPIPPNSTLATTASSNQSGSNDFVKKLFLMLQEDSYKEVVRWTVKGDSFVVINTNEFTKDILPKHFKHSNFASFVRQLNKYDFHKVKISNEAKASYPYGEDAWEFKHPEFRINDAEALENIKRKGPTAKKSASNVTIKTEANNNGTQPTCNHNYSQLVSATNHLKEQVESLKNDKHSLYQEISVLERKYKTVVENIVAINTFNERYYRSMNVLINSIVQNGMKLPPLDFPPPVQLGPDSGIGSNLGPISSDTALPSISHHLSSPLPHHQQLLNRTIRPISSPIDGIPLVKLQQQSLGQNLQAPIGTPSAVPFSEEASSSIQAATPAPLAQPVAQPINQPPPPPPPPATQQQPLPPPPPPATATSQIPSAPPPPTQQQVGTSSSSVPTISPKSQGIVVSNSASPTTSAQISTTSVPNPKFHVLLVEDDNVCIQLCRKFLVKYGCSVTVVTDGLNAISTVEHTKYDLVLMDIVMPNLDGATATSVIRSFDTKTPIIAMTGNIEDNDLVTYLQNGMSDILAKPFTKDDLYAILSKHLLDPKENKQDNEPTVKKQKLS", "function": "Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.", "AFDB_id": "AF-Q5A4X5-F1-model_v4" }, { "swissprot_id": "P46937", "sequence": "MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL", "function": "Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3).", "AFDB_id": "AF-P46937-F1-model_v4" }, { "swissprot_id": "Q9UW22", "sequence": "MNSHSEALFEINQRLSSHIRTMSNFPVFDPQKITNDVEANIKRMTSILKSKRLTREDEDLMKMINDCSKVLHEMLLERIMLQQDSIQFFTEKEASDSPFSNSADTIDEDDDKKIKSRRLTKKQLLVLEGWFQKHKNHPYSQKDQTNLLIKSTKLSKSQVQNWISNRRRKEKNTKVSPELAALLLTG", "function": "Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with A1 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating.", "AFDB_id": "AF-Q9UW22-F1-model_v4" }, { "swissprot_id": "P39696", "sequence": "MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIKNRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTEQLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESDITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELYTLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV", "function": "Dispensable for transformability. Not known if it can act as a pyrroline-5-carboxylate reductase.", "AFDB_id": "AF-P39696-F1-model_v4" }, { "swissprot_id": "P27816", "sequence": "MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI", "function": "Non-neuronal microtubule-associated protein. Promotes microtubule assembly.", "AFDB_id": "AF-P27816-F1-model_v4" }, { "swissprot_id": "O96910", "sequence": "MKVAIIILSLALVAAVFADQNCDIGNITSQCQMQHKNCEDANGCDTIIEECKTSMVERCQNQEFESAAGSTTLGPQ", "function": "Water-borne pheromone that attract the marine mollusk Aplysia into breeding aggregations and coordinate male and female reproductive behavior within the aggregation.", "AFDB_id": "AF-O96910-F1-model_v4" }, { "swissprot_id": "P09818", "sequence": "MHLVVCIKQVPDSAQIRVHPVTNTIMRQGVPTIINPHDLAALEEALKLCDTYGGEVTVVTMGPKMAEDALRKALTFGAHRAVLLTDRHFAGSDTLATSFALAQAIAEIGETFGTPDVVFTGKQTIDGDTAQVGPGIAKRLDLQQLTYVAKILSIDAASREITVERRAEGGSQILRTGLPCLVTMLDGADAIRRGRLDDALRAARTKVVKWSAADAGIAEPANCGLRGSPTVVKRVFAPTSREQKARQIDTTNKPLREIADGLIAAIFADRPALKHDLGSTGQQGAPDVDRES", "function": "May play a role in a redox process involved in nitrogen fixation.", "AFDB_id": "AF-P09818-F1-model_v4" }, { "swissprot_id": "B3DWU5", "sequence": "MILVDISNSVTKIGLFKEGELRLLEKIPTAQISFEQTERIAQMYPLEDLILCSVVPQKNLFFEKPFLGRLYQIDPTVPLGIPIHYPNPREIGADRLANAVALSLLYGYPAVAIDFGTATTFDIVDQKGAFCGGIIAPGLSMMTSYLHEKTALLPLVEIKEPSKVIAQSTEEALRVGAVHGYRGMVQYLIEKIKEELGLLQKFIVVATGGGSRLVCSQLKSVDVIDEMLTLKGIRLIGEILIKRKRKDLPFPEGYPPMKGESFPFSLFTHNQ", "function": "Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.", "AFDB_id": "AF-B3DWU5-F1-model_v4" }, { "swissprot_id": "Q6NL34", "sequence": "MIENSFKMEMHFKNRWQAASLFLRYPRTVTLCLSGKSGDMDESVNLSTSMGDVEASMLNHNVSFSSTMVTSNGDLSLPKLSVTLSAEEILKLRSGRPKNAVESPHAGVPMETSLAAEEEANGDEEEESVRVVDIEDTLELTSNGNEAKPEDQELAIAPVLQYFQGALVELGRRCWTSSTEAQHYTKGCYWSPDGTCLLVPVHLDGMHVIEMPSDLYSADTVQPARSLTKLQSEVHVPEGGTVYDCVWYPHMNSLQPETCLWLATRQHEPIHMWDAFDGSLRCSYSGYDAVDEVMAAISLAFSHDGEQIYAGYKRCIKIFDTSRPGRFCDDYPVKFAISCIAQTTAHPHTLTCGNWHGYIQHFDLRCSHKQGPLFTLGGHKGGITQLRYGEFGNGEWHLFSGARKCDKILQWDMRNYKQPLVELQRHVDTNQRIQFDLASDSNWLASGDTRGFVNVWDLKKYGDPSVLPLHSDCCNGVALNPAMPILATSSGQFHFTDQSAQGDNVTLNGTETTELPAPADVNQNQKEVLYENAVVMWWCGQTG", "function": "RNA chaperone that plays a key role in Cajal body formation. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs). Probably acts by mediating localization of scaRNAs to Cajal bodies.", "AFDB_id": "AF-Q6NL34-F1-model_v4" }, { "swissprot_id": "Q6MMJ3", "sequence": "MGRHKKPETIYDIHEANDRLADVFRNHGFDLVSHSQRQQLAHFYRLLMLNQEKENFTRLLKLRDVAIKHFIDSIIIMKYTDLQFPLLDVGTGPGFPGIPLKIMYPDQQILLGEGVQRRVEFLKHVRSEMNLKNLDILGRNINKHCVYPVRGAITRAVEDIGNTLGNVMSCLEIGGRVYFMKGPGVGPEIEAAKKDWGEYYKLVQDVAYSLPQTPHERRLVVYEKIKNMPLPEEDEGEELLMDELSNEEKRRWAKY", "function": "Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.", "AFDB_id": "AF-Q6MMJ3-F1-model_v4" }, { "swissprot_id": "Q04368", "sequence": "MDLLKFSSLAISEINFLHESSFDSIDHSWFLLIGCKLDQDDEIYIPINGNEAESQWYIEKVIRIPMQENDKINQERLERRINLTKVTQKDICILGILDLCQLEEDENITNKVTEKVLTQLTALALKYLIKYNVFRQHTSFQEAVNSLKGYKIENSVQIGAEIILDFLQDKVQIKDVNDRYQIPTPNNTVDPGFDEFQLIDMKDKEINIQKYNNNTIRKLLEKINRMIIFLKNYDATDKPFSSTQDVILRKISMLVTQLQRGGTSDMNYLLDNKINEIKLLEISCKQWEISNMLKK", "function": "Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response.", "AFDB_id": "AF-Q04368-F1-model_v4" }, { "swissprot_id": "P11927", "sequence": "MNVTSPKDGNHSFSKKNRFNTNKPRFHKLNEQAQSINLPEDRDSIVSSNTTSIMTDDAFDYNEGIASRTKNINSDSDRSNDTIKQNNYNKRETGYNPFYNGSGINQRYTQFRKREFEPTLAENKAEEYISDEDNVKIDEDNIENELQFTPKIKEASILRSSLLGQRNVLNTRNPKSKESHIKVKPIINNKSSSQRKSSAALRKQLGKPLPLPYLNSPNSDSTPTLQRKEEVFTDEVLQKKRELIESKWHRLLFHDKKMVEKKLESLREYERKRMPPRGTDVSSSEQDNSFKISTPTKSYVSLEQKPLPNLSAMNNFNDVTDNKEKEETNNNILKFQAQRDPLQILQSEIEMHTKKLDTIIELLKDDTDSKEKRKVVTNDNAAPEQMVNKGWRKNVMMIYKKSGNIMKKYREYFLWTICILILLYCNIYVYYRF", "function": "KAR1 is required for function of both intranuclear and extranuclear microtubules. KAR1 helps localize CDC31 to the spindle pole body (SPB), CDC31 then initiates SPB duplication via interaction with a downstream effector.", "AFDB_id": "AF-P11927-F1-model_v4" }, { "swissprot_id": "P00963", "sequence": "MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL", "function": "May amidate Asp of the extracellular death factor precursor Asn-Asn-Trp-Asp-Asn to generate Asn-Asn-Trp-Asn-Asn.", "AFDB_id": "AF-P00963-F1-model_v4" }, { "swissprot_id": "P25439", "sequence": "MASPSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHPGAYGHPMQHGPPGQGPPGHHMPPHHQGMIFSKGPHMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPGPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDDDDMD", "function": "Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast lineage, as part of the Brm remodeling complex, suppresses the formation of ectopic neuroblasts probably through interaction with erm and HDAC3.", "AFDB_id": "AF-P25439-F1-model_v4" }, { "swissprot_id": "O23215", "sequence": "MKCPYCSSAQGRCTTTSSGRSITECSSCGRVMEERQTQNHHLFHLRAQDTPLCLVTSDLQTAAQPSPEDEEDPFEPTGFITAFSTWSLEPSPIFARSSLSFSGHLAELERTLELASSTSNSNSSTVVVDNLRAYMQIIDVASILGLDCDISEHAFQLFRDCCSATCLRNRSVEALATACLVQAIREAQEPRTLQEISIAANVQQKEIGKYIKILGEALQLSQPINSNSISVHMPRFCTLLQLNKSAQELATHIGEVVINKCFCTRRNPISISAAAIYLACQLEDKRKTQAEICKITGLTEVTLRKVYKELLENWDDLLPSNYTPAVPPEKAFPTTTISTTRSTTPRAVDPPEPSFVEKDKPSAKPIETFDHTYQQPKGKEDKQPKFRQPWLFGTASVMNPAEMISEPAKPNAMDYEKQQLDKQQQQQLGDKETLPIYLRDHNPFPSNPSPSTGISTINWSFRPSVVPGSSSNLPVIHPPKLPPGYAEIRGSGSRNADNPHGDF", "function": "Plant-specific TFIIB-related protein that may be involved in an intracellular signaling pathway between plastids and the nucleus. May act as general transcription factor (GTF) of RNA polymerase I-dependent transcription and rRNA synthesis. Forms a ternary complex with TBP2 and the rDNA promoter region.", "AFDB_id": "AF-O23215-F1-model_v4" }, { "swissprot_id": "Q52TG1", "sequence": "MEEFKKYFERDSYWQQHFLYPLLFQEYIYALAHIHNHGLNGSIFYESGEVLGYDNKSSLILVKRLILRMYQQNFLIHSSNESHQNGFVGHKNPFFSQMISGGFAVIVEIPFSLPSLIEKKKKEITKSQNLRSIHSIFPFLVDQFSHLNYVSDILIPYPIHLEILIQIIQSWIQDVPSLHLLRFFLYEYHNWNSFITRKKSLSTFGKENPRFFWFLYNSYVSEYESVFCFLRKHSSYLLSTSYRNLIERTHFYGKIEHLPVVCSNDFHKNLQLFKDPCMHYVRYQGKAILASKGTSLLMKKWKWYLVNFWECNFSFWFQPYRIHINQLSNSSFLFWGYFSIVLINPLPVRSQMLGYSCLIDNTLTKKLETLVPIIPLIGSLSKAKFCNVSGHPASKPIWTDLSDSDIIDRFVRICRTLSHYHSGSSKKQSLYRMKYILRLSCARTLARKHKTTVRAFFQRLGSGFLEEFFTEEQKFLSLVLPRTSLASGSDRVYKERIWYLDIIRINDLVNYSRLAMELCTGNITKRIEKRSKIAFLFSTDMLKCSCSGS", "function": "Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.", "AFDB_id": "AF-Q52TG1-F1-model_v4" }, { "swissprot_id": "Q9C658", "sequence": "MAADNTGSKSSSAADSYVGSLISLTSKSEIRYEGILYNINTDESSIGLQNVRSFGTEGRKKDGPQVPPSDKVYEYILFRGTDIKDLQVKASPPVQPPASTINNDPAIIQSHYPSPMPTSGSLPSTASGSLPDISSHNGQPGQHGMGFQNAMPLYQPGGNLGSWGASPQPPMYWQGFYTPPPNGLPQLHQQSLIRPPHGLPMPNSLQQPLQYPNFNTPPPPTGSSSLQGSSLPEAPSSLFPFSTSSQMLAPSSLPFPGLPPVTLSSSLQSTLQSAPSPSLASEMAPPLLSNKAPITAPPTLPQDTNLLSFSLSTTRATEASTGLPLSNKPSVVTGPISPPQTTPLTSAPVAGVSSSISQDKPKPLLVTPGQLLQSGSSAVSLSPPSTNADKDVEVVQVSSSAGLEQSVPVTSEAQPPILPLPSSARPTQKPNGHSFPNHNGYRGRGRGRGRGAGRSHQVMKFTEDFDFTAMNEKFNKDEVWGHLGKSTTLDGDEDDDSPTVDEAELPKIEAKPVYNKDDFFDSLSSNTIDRESQNSRPRFSEQRKLDTETFGEFSRFRGGRGGRGGYGRNNGYSRGGYGGRGYGGYGGRGGGGGGYGYGGRGQGRGVSNRTT", "function": "As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.", "AFDB_id": "AF-Q9C658-F1-model_v4" }, { "swissprot_id": "P73625", "sequence": "MSDSTNLTIAEETLALLEWPRLCQHLSTFTQTPLGAIAARYLLPPSQWEESRELLAQTQAVESIENSPESNWHFKGIADITEPLARVERGGLVTGLELLAIAGTLAGVRRLRRVIEERDDLEILQTLVAEVRTLPELEQAIHHCLGEDGKVAERASPKLGEIRQKLKAVREQIQQKLQKIIQRQSNALQEAVITQRGDRFVLPIKAGYKEQMPGIVHDSSASGNTLYVEPQAIVELGNKLRQARRQEQTEEERILRQLSDQVLEVLLDLEHLLAIATRLDLATARVRYSFWLGAHPPQWLTPGDEKPITLRQLRHPLLHWQAEKEGGPAVVPITLTIDSQIRVIAITGPNTGGKTVTLKTLGLVALMAKVGLYIPAKETVEMPWFAQILADIGDEQSLQQNLSTFSGHICRIIRILQALPSGVQDVLDPEIDSPNHPIFPSLVLLDEVGAGTDPTEGSALAIALLRHLADQPCLTVATTHYGELKALKYQDARFENASVEFDDQSLSPTYRLLWGIPGRSNALAIAQRLGLPLAIVEQAKDKLGGFSEDINQVIAGLESQRREQEQKAANAQKLLQETEIFYQQVSQKAASLQARERELKSYQDQEVQQAIAAAKEEIAKVIRQLQRGKPSAQKAQQATEILGQIQAEQKAKVAPKPIGYQPTVGERIRIPSFGQTAEVTQVNATAQTVNVTLGLMKMTVPMADIESLNGKKVEPPPKSEPVPKKVKAEPPATEAKSPPVLVRTEKNTLDCRGDRLERAESRLEKALNQALDAGVLWIIHGKGTGKLRQGVQEYLSHHPLVKSYALAPQNDGGAGVTIAYLR", "function": "Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.", "AFDB_id": "AF-P73625-F1-model_v4" }, { "swissprot_id": "P38369", "sequence": "MCMMGSVFSRKGMLCVLAVWCAASAAYPLRLRYKFRKGDTHRINSLIREDVFVNDTLAHTAEITNRITVHVSEVRVAHGSAPDAARYVCHFMTSEKSPNNTFRWGRHYESIFWRDAFGVYDIDRSFFMPVVRNVPVFPDYDIEVGDTWEHEAEEAHDLRDGFGIQTPFIVPFTVSYTYRGEVQRGSRRYHHITAAYSMSYESPKRTHGVQRNAKEGMYPVRTTGVSKQNLYWDNELGNIAEYDDEFRILLYLSGGTVLRYQGTATAKNFAPERFDPARTVVELQETLKDLHMPDAKVRETEEGVTISIENVQFDADSASLAPSEYEKLRKIAELLRAFPDRELLVSGHAARRGSVQDQQRISEERADVVARYLQELGVVDAAHVYTRGCGAQQSIAPNDSEDGRRKNRRVEITIISK", "function": "Could function as a porin.", "AFDB_id": "AF-P38369-F1-model_v4" }, { "swissprot_id": "P16664", "sequence": "MRAHRIDTFLIRENIKLEIIHESNSYFGGEHISIAFRFKHLGSQHELFNYKEKLLTVDKAVEEKLEQQAKVQDDGEGTMENQTWSLKSLLGAFKRTGEPEESVDVDNMKMLNESKMLREKIQKQMYFHQPVTLISGYVQISGVFQYDSEVISESKFKQDEVKMVGLDIVPGHTTNSVLALEDGEHFKGKRNLTNYLNSDYTNVTNGLLFSESGSRGRTGTYNERTLMISNDTSIKTLPLLLIPQTLLFSEISLEPGEVRTFYFKSTKLPKDICPSYSSSKVASINYTLEVGADVLSDDNIEKFSNRVPITIAPYISSNAEQYTSRLDKPAIILKTGNIKELKPRLFTRKVSTASAVSFGRRKSSIIDIDSPLEDNEFVKRVKKNFIELVESNQNVSRDIDELIDLQMGVQFGKDEDSSDPEPNDSHFSNEMVTSAESSLRSDAVTKRRKSYSVRDNISNLEQKMWNDCSLVKSDENSNLLPQLINLQNAYQINRNNETMAKVSLSAPFYKTTDDINLVIELDPITTPLLKVTSLTVSLESFEIINPKYKTEGKGIGSKPKGNSVYEKHFICFDECKSVSVKLLPPRSPTNQITGQFKTDVFQHKWMIGLKFVIIAKTESITLDQFYEDKKGILFHSKENLEGEEFTCYVPIPILCTSEDFMGW", "function": "Required for proper mitotic growth.", "AFDB_id": "AF-P16664-F1-model_v4" }, { "swissprot_id": "Q58292", "sequence": "MHYFSEKPTTKSDVKIVEDILRGKKLKFKTDSGVFSYGKVDKGTKILVENVVVDKDDDILDLGCGYGVIGIALADEVKSTTMADINRRAIKLAKENIKLNNLDNYDIRVVHSDLYENVKDRKYNKIITNPPIRAGKEVLHRIIEEGKELLKDNGEIWVVIQTKQGAKSLAKYMKDVFGNVETVTIKGGYRVLKSKKL", "function": "Probable methyltransferase that uses S-adenosylmethionine as the methyl donor. Binds neither NAD nor NADP in vitro.", "AFDB_id": "AF-Q58292-F1-model_v4" }, { "swissprot_id": "D5ARG9", "sequence": "MLSLALPCRSWAHRLPAALKFGLLAVAMIALMRIGSLAGQGAAVLVVAALTASLGRKAIRQSLVTLRPLVWIVAVILIWDSLQGAVAQGVLFGLRVLAMVGLANAVTLTTPLPEIVALIERLAQPLARFGISPRIPAISVALVIRFVPVLRARHDTLAEAWRARSARKPRGKLLAPLTFSLLDDADHMADALRARGGLALPRKGRDTVGT", "function": "Probably involved in biotin uptake, although complementation experiments in E.coli do not indicate a clear role.", "AFDB_id": "AF-D5ARG9-F1-model_v4" }, { "swissprot_id": "P80483", "sequence": "DGIADASKKFSDATYPIAEKFDWGGSSAVAKYIADASASNPRQAALAVEKLLETGLTMDPKLVRAAVAAHSKALDTAVSNPKLVASKEDFAAVNEALARMIASADKQKFAALRTAFPESRELQSSLFAGNNGYEAEKAYDSFKALTSAVRDASINGANAPVIAEAARSERYVPDGPVGRAAKKFSEATYPIMEKLNWVKSPEISKYLATASSKDPKMMAPGIDKTLEVALTMNQNLINNAVYAHVRAIKGALNTPGFVAERDDFARVNLALAKMIGSADPAKFKALLTAFPGNADLQMALFAANPEQAKAAYETFVALTSAVV", "function": "Water-soluble antenna for capture of solar energy in the blue-green range. Peridinin is an asymmetric carotenoid.", "AFDB_id": "AF-P80483-F1-model_v4" }, { "swissprot_id": "Q50703", "sequence": "MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESLEDELDELDENWKGSSSDLLADAVERYLQWLSKHSSQLKHAAWVINGLANAYNDTRRKVVPPEEIAANREERRRLIASNVAGVNTPAIADLDAQYDQYRARNVAVMNAYVSWTRSALSDLPRWREPPQIYRGG", "function": "Plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2). Interacts with TLR2, leading to the subsequent activation of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa-B) signaling pathways. Induces macrophage activation by augmenting the expression of several cell surface molecules (CD40, CD80, CD86 and MHC class II) and pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-12p40) within macrophages. Also participates in adaptive immunity by directing Th1-polarised immune responses. Stimulates specific humoral and cellular immune responses in tuberculosis (TB) patients. Induces a strong IgG(1) antibody response and an increased Th1/Th2 type immune response in mice.", "AFDB_id": "AF-Q50703-F1-model_v4" }, { "swissprot_id": "P21876", "sequence": "MRKRISAIINKLNISIIIMTVVLMIGCGQQPEAGKTGVSGGVNGNLGNSLMELGRSAENAFYAFIELVSDVLGFTAKSDTTKQEVGGYFNSLGAKLGEASNDLEQVAVKAETGVDKSDSSKNPIREAVNEAKEVLGTLKGYVESLGTIGDSNPVGYANNAAGSGTTAADDELRKAFKALQEIVKAATDAGVKALKIGATTLQANGGADNKEGAKILATSGGNPAAADVAKAAAILSSVSGEEMLSSIVKSGENDAQLAAAADGNTSAISFAKGGSDAHLAGANTPKAAAVAGGIALRSLVKTGKLAAGAADNATGGGKEVQGVGVAAANKLLRAVEDVIKKTVKNVLEKAKEKIDKARGSQEPVSESSK", "function": "The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune response evasion.", "AFDB_id": "AF-P21876-F1-model_v4" }, { "swissprot_id": "P57766", "sequence": "MFKIVYPNAKDFFSFINSITNVTDSIILNFTEDGIFSRHLTEDKVLMAIMRIPKDVLSEYSIDSPTSVKLDVSSVKKILSKASSKKATIELTETDSGLKIIIRDEKSGAKSTIYIKAEKGQVEQLTEPKVNLAVNFTTDESVLNVIAADVTLVGEEMRISTEEDKIKIEAGEEGKRYVAFLMKDKPLKELSIDTSASSSYSAEMFKDAVKGLRGFSAPTMVSFGENLPMKIDVEAVSGGHMIFWIAPRL", "function": "One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.", "AFDB_id": "AF-P57766-F1-model_v4" }, { "swissprot_id": "Q5QNQ6", "sequence": "MGKAAALSRGGGCAGRSRGLSSLFTVVPCLSCHTAAPGMNSSAFGSGPASKPQLQPVQAPERELLSKQVCQPISEPASRSEPGSQTTSVPRPSGVGQESELQGLWPGSENGTRSVSIIKASPELAMPSPLQSTVGSLPVTKPESKLVPKTQSFLRQGQAKISVGTPVSGIGVQMVSPPLDSYKGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRATINLASTHFETEDSCGILLCNGARTYHLKASSEVDRQHWITALELAKAKAIRVMKTQSDDSGDDDEEPAAPADNSELHHTLKTLSLKLNDLSTCNDLIAKHGAALQRSLNELDSLKIPSECGEKLKVVNERATLFRITSNAMINACRDFLELAETHSRKWQRALNYEQEQRVHLEETIEQLAKQHNSLERAFCNTPGGPASSSKSFSEGSFLTSKGENSEEDEDTEYFDAMEDSTSFITVVTEAKEDRKPESGPGTTTVDWTSADNVLDGASFMPKNSCKVKRRVRIPDKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVNCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRMEDMGLRSLCEQVSHHPPSAAHHVFSKHGWSLWQEITIASKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTKDRCQLKFVPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDDQMECSKIVHSSPSSDGRQKTVYQTLPAKLLWRKYPLPENAENMYYFSELALTLNEQEDGVAPTDSRLRPDQRLMERGRWDEANTEKQRLEEKQRLSRRRRLESCTAGCGGEEEKESDGYVPLWFEKRLDPLTGEMACMYKGGYWEAKEKKDWHMCPNIF", "function": "Binds 7-ketocholesterol.", "AFDB_id": "AF-Q5QNQ6-F1-model_v4" }, { "swissprot_id": "Q09724", "sequence": "MRCSVAVRASSIYVKNPQLRKSFLHSNYVQLIQESPNFLILQHNNLLPREAKSLRTELKAKVPGSKLQVIRGSIFHHALKVYESIDRLSNGCVDMQKVNLIETHKKAQKIKLDIDNLFVGPLAIFTLGPKLSPEAIRGFMSVLKGYQNKILLLGIRAESKGMDPFEVENLSKIPSLEFLQSSLLSVLSSPASQLRRILDLSKANVAYTLERREPSE", "function": "Involved in mitochondrial genome encoded proteins translation.", "AFDB_id": "AF-Q09724-F1-model_v4" }, { "swissprot_id": "Q54T76", "sequence": "MNDVSRIFPGFYIGSLPAVNRNTLDKYQITHVCSVLNEFQPKWTKIYKYLHIDIYDSPSVDIMKYFDKTFQFIEEGRKDGGVLVHCFAGISRSATICIAYIMRKLNISFEDAHGLVSDARPIIYPNESFIKQLKKYELILKKNRENPQIVEKESEEEDDDEDDDDDDYDSDEDDDDDSEDDDFEEEFDNVVKKKNNNNKKVNVKNTTKVFSNISISSEQTTTSTTTVPTPTLNPETKIEETTTTTTATATATLVEEVVESTSPKATLGEHRYSCRKCSKDLFLDFDILDHEQGQGQTSFKWNKRDNTTCNKSVGANGEQIEDQNKVICTSYFISEIEFSLSQTYSGMEGKLFCPSCNEKLGSWSWSGEQCSCGAWIAPSFQIPKTRVDEKKVLK", "function": "Has a dual specificity toward Ser/Thr and Tyr-containing proteins.", "AFDB_id": "AF-Q54T76-F1-model_v4" }, { "swissprot_id": "P91167", "sequence": "MYNTDYKKYNVDIFHPAHFEDIQEESADCGPNVQEVRQFLESNRLEYALQSVLLNPPFGHSEQELKNRAVLLVAEVIHAFRQTDIEESVHKLSNENGDILMKYIYKAMQLCSDSATCLSLLLWHSQLVSKFGQGSIVRVLSNRQRL", "function": "Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.", "AFDB_id": "AF-P91167-F1-model_v4" }, { "swissprot_id": "P47177", "sequence": "MYFLNQLIFQDVSVMSVDKREDMSRSFQKCLNLRYPIIQAPMAGVTTIEMAAKACIAGAIASLPLSHLDFRKVNDIEKLKLMVSQFRDQVADESLEGNLNLNFFCHDIVDKPTDLQTANWAKLYRKSMNVPIDMNEIKFDNGNVSFKAFEKENALQDFFQYLSDGFRPKIISFHFGHPSKSTIEYLQKIGILIFVTATSVREVRLLARLGINGIVCQGYEAGGHRGNFLVNDPKDDENLSTVQLVKRTVDELAEMKNKGLIHATPFVIAAGGIMDSKDISYMLSQQADAVQVGTAFLGCSESNASKNFSSPFTRETTTKMVNIISGKPARTISTPFIEKVIANFQGEELPPYGYMYSAFKQVRKKYPELANFILAGQGFQNVQSGITTDKKIETMGARLKIDGK", "function": "Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites.", "AFDB_id": "AF-P47177-F1-model_v4" }, { "swissprot_id": "P09615", "sequence": "MDISYIFVICLMALCSGGSSLSQVEGKQKSGRGRGSMWWGIAKVGEPNNITPIMYMDPAIHSTLRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTRNFSRGKNLFGKIVDRGCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSPQANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHNNEAGRAHVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNSLRATNALAPVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDHMPDILLENSHPISKIHHPNMPSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHKPPGSKDLVYLEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL", "function": "Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, and diffuses long distances despite its lipidation. Lipophorin is required for diffusion, probably by acting as vehicle for its movement, explaining how it can spread over long distances despite its lipidation. In non-neuronal cells, wls directs wg secretion via clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps26 and Vps35) to sustain a wls traffic loop encompassing the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi. In neuronal cells (the larval motorneuron NMJ), wg signal moves across the synapse through the release of wls-containing exosome-like vesicles.", "AFDB_id": "AF-P09615-F1-model_v4" }, { "swissprot_id": "Q5W7C1", "sequence": "MMASMAALLQRLLVVVNQVDPGAPGFWREFLVGMLKPVAATAVVAMAVALSFTQRLGLEGEMLYAMARAFLQLSVIGFVLQFIFTQKSAAWILLAYLFMVTVAGYTAGQRARHVPRGKHIAAVSILAGTSVTMALLVALRVFPFTPRYIIPVAGMMVGNAMTVTGVTMKKLREDVGMQRGVVETALALGATPRQATARQVRRSLVIALSPVIDNAKTVGLIALPGAMTGLIMGGASPLEAIQLQIVVMNMLMGASTVSSILSTYLCWPAFFTGAFQLNDAVFAAD", "function": "Associates with STAR2 to form a functional transmembrane ABC transporter required for detoxification of aluminum (Al) in roots. Can specifically transport UDP-glucose.", "AFDB_id": "AF-Q5W7C1-F1-model_v4" }, { "swissprot_id": "P39735", "sequence": "MAPSIATVKIARDMVLPLRIFVNRKQILQTNDKTSNKSNATIFEAPLLSNNSIICLKSPNTRIYLSQQDKKNLCDEIKEDLLLIVYELASPEIISSVLSKIRVGHSTDFQINVLPKLFAGADTDNAVTSHIQSVTRLAKFKYKLHYKHKWELDIFINSIKKIANLRHYLMFQTLTLNGFSLNAGPKTLLARKIEKQPQVPNLLIENGDADALDTPVEEDIKPVIEFMYKPVINLGEIIDVHVLHRPRRHKVRTQSKQPQEE", "function": "Catalyzes 3'-non-homologous tail removal of RAD1/RAD10-dependent single-strand annealing recombination intermediates. Plays a key role in targeting RAD1/RAD10 complex to 3'-flap cleavage substrate in recombination. Also contributes to the integrity of ribosomal DNA arrays.", "AFDB_id": "AF-P39735-F1-model_v4" }, { "swissprot_id": "Q48743", "sequence": "MKRLLAFCLLFFAALGQAKVPPPARSAADAEIQRAVAAFMQQYQVPGVAVGITVDGAERYYNYGVSSRKTQAKVGANTLFEVGSVSKTFTATLASYAQVNQQLSLADHPGKYLPEMKGHDFDKVTLLNLGTHTAGGFPMQVPTQVKTDQQLTAYFQSWHPQYPAGTKRTYANPGIGMLGVIAAKSMRMPFQKAMTGVLLPKLGLTNTYLTVPPAKMAFYAQGYDDKGQPVRMSPGALWEPTYGIKTTARDLLRFVEINLDQVKVEPKLKRAIDGTHVGYYRLGEMTQGLVWEQLPYPASETSLQANSSQKVIFESNAVAALTPPRPPQANVLINKTGSTRGFGAYVAFNPARKIGIVLLMNRSVPMDGRIKLAHTILDTAGGMAK", "function": "This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.", "AFDB_id": "AF-Q48743-F1-model_v4" }, { "swissprot_id": "Q7XPF8", "sequence": "MHPPSLVLDTLKRIKLYIAMKLLLPNSEVPRIYWEKAQHLCGFLSMKLISRARCVASSVKQSYSFLVCKSNPLVVQLVYFVIISFAGFLALKNLKPQGKPGPKDLDLLFTSVSTLTVSSMATVEMEDLSDRQLWVLILLMLMGGEVFTSMLGLYFNNANANRNENSQRSLPSISLDIEFNSPANNGDHKITECGQSEETMSQNQVQQNKSITYNPCAVLVRIVTGYFVATVISSSVIIIIYFWIDSDARNVLKSKEINMYTFCIFTAVSSFANCGFTPLNSNMQPFRKNWVLLLLVIPQILAGNTLFSPLLRLCVWVLGKVSGKAEYAYILQHPGETGYKHLHVRRNSVYIVLSVTGLILLQVMFICSFEWNSESLEGMNWLQKLVGLLFQSVNTRQAGESILDISTLSPSTLLLFAVVMYLPSDASFLTANADNQPLTDKKTNSISRALWRNFTVNKLSCLAMFTFLACITERKSISSDPLNFNIFSIVFEIISAFGNVGYSLGYSCQKLLKPDATCKDASYGFVGRWTEEGKLIVILVMFLGRLKEFILK", "function": "Functions as a low-affinity sodium transporter.", "AFDB_id": "AF-Q7XPF8-F1-model_v4" }, { "swissprot_id": "Q2J8A4", "sequence": "MMLEARTAFTLLTVLPLRGPEHTDRRLAGRAMALAPFVGLALGLLAGSAVFATRIVTAVPGQRAQTLLPAVVGVTVLALVTRGLHLDGLADLGDGLGAWRARGRDRALEIMRESTIGAFGAIIVLFVVLLQVGALSTTISAHRGTLSILVAAMTSRLAATLACTGAVPPARPDGLGALVAGTVRTRDAALSFLAVCAVAALAGLLDFDGGGPGRALRAVLAVWVGTGVSFLLRRYLLTRFGGITGDILGGLIEITAAATLLVMAMTIPTPVLHTLGLH", "function": "Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.", "AFDB_id": "AF-Q2J8A4-F1-model_v4" }, { "swissprot_id": "A6TR78", "sequence": "MPQIKLLDNLTINKIAAGEVVEGPYSIVKELIENAIDAGGTAITLEIKEGGKKYIRVTDNGIGISSDDVNRAFMRHSTSKISSLQDLSTTFSLGFRGEALASISAVSQVEMITKPKDQSYGILTEIEGGEITNQKKVGCPTGTTMIIKNVFFNTPPRYKFMKSTQAETARISEMISRLALSSPHIAFKYINNQTTIFTTPGDGTLSSVILSVFEKNFFQNLIPLSVNKPALELDGFISQVDFVRGNRSFQIFYVNGRYIKSKLISQAIEEAYKGKIPINKYPICVLNIKIDPEDADINVHPSKTEIKFHKEKEIYHYIYNYVTQVLSESSTISEIMMIPSTKNQHQQHHHLKEINLSQENIQSKESIGVKQQDKVMVADEQEKVKEYNSQYVMDSRPKVQPPPMVNTLKTEDTQLNVASIISNELPVESRGIRTNPQLQKNFIKTYLQNYKVVGQLFNTYIVIEKDQSVYLIDQHAAHEKLLYIQFHEELKKETVASQQLLTPVVLEFSHEDYITLIENISEFIPLGFELEAFGQNSIIIRAVPLLLDKPKDYNFIFELIDQVKNEKHVKPDYIREKIIQRSCKEAIKAMDILDIQEIQQLIRDLEKLEPPLTCPHGRPILLTLTKNQIEKLFKRIQ", "function": "This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.", "AFDB_id": "AF-A6TR78-F1-model_v4" }, { "swissprot_id": "Q5JHN1", "sequence": "MKIEKLIIKDFRSHALTKVNFSSGINLIIGQNGSGKSSILDALLVGLYWPSKPKDLKKDDFERINGSGTEITVFFEKGNVKYQIHRNIGRGLAFVKYHDGSSWKTLETGQKPVRDWMEKLVPYDVFLNAIYIRQGEIDAILESDESREKVVRQVLGLDRYENSYKNLLDVRKEIDARIKAIEDYLKSTENIDELIGNLEKELTSVLREINEISPKLPELRGELGGLEKELKELEKTAEELAKARVELKSEEGNLRELEAKKSGIQSMIRETEKRVEELKEKVKELESLEEKAKEYERLSRFYRNFTEGINRIEKLLATYSQQAENLRERIDELSKKEARVKELLKEKEGLQKELGALEEDLKAYQRAKELMANLERLKKRLTLSEEEIEKLEAEIQKARERKEEIMKELEEIGSRRGELKSIAGERNKALMELKKAKGRCPVCGRELTEEHRKELLEKYTAELKEISAEMKELEKREKKLRAELVEVEKTLKKERELFALKEVLEQIRETEEKLKEYDLEKLEEANEKAEELKKKLAGLEGEIKSLEDEIKKGELLKKKLALVEKKLRELEEERASLLGELKKLGFGDVKELEERLKELEPAYKRYIELRPARDELKREEDLLKSLKLDLTAILKEIEKTSKRVEELRKRVEELEKSYDKDRHEELKGKTRELSNELAGLEARLKSLEERRDEVKASLEKLREEKETRKEKAKELEKLKKARERVQRLREKVKAYKNLLKEGALAKVGEMASEIFEELTEEKYSGVTVKAEENKVRLGVVYNGKEYGLGFLSGGERIALGLAFRLALSLYLAGEISLLILDEPTPYLDEERRRRLVDIMQRYLRKIPQVIVVSHDEELKDAADRVIRVSLENGVSVVREAEVG", "function": "Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.", "AFDB_id": "AF-Q5JHN1-F1-model_v4" }, { "swissprot_id": "A8Y3H3", "sequence": "MRQNRRASMIVNRILITLIVLVSLSFLFLRAGPKFSEADRACIQDEWQENKSLNVSSEINNETYQIVFADVQKEFKWIFLPKEISGNPDILMIVSSNRDNFARRNVIRKSWMNSDKNKIVAEKRMKILFLVGVNSENEKENTVVLKEAEVFGDIIVVDLEDNYQNLPYKSLTILLYGQSKTAESVKLIGKIDEDVIFYPDQLTPLINDGTINMSISAIYGEKWNAGVEVSNKDETNKWFIPKYSFKCQLLPSYLSGPFYLTTRKAAERILKSTKHRKFISVEDVFITGLLAGDVGVEKKQLPSMYMYDETTTDTAKAEILAWHNFKNNAEFLESWENLRLSRCKACRKSRNFRGSRSQLDEERNQ", "function": "Transfers N-acetylgalactosamine onto carbohydrate substrates. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.", "AFDB_id": "AF-A8Y3H3-F1-model_v4" }, { "swissprot_id": "Q10659", "sequence": "MAELHLSFPAYSLCWINNHQMAVGGGGGTTKSGVKNKLKLLSYEDYEPEVGEGHTKFIEHGEIELKHSDDAVMSLGYFKNELIAGINNTIDGKLIDHLRLYGRKDKLFEEKNALRLTDFDNDEQYQRLCLFEPLHDAICISCTNKSFFIISKNDHKVLFEKHGSDVYDVSSTEDKLAIAVDDRVEIYDWNTFELVQVLYMPVERATVRGVSFLPNQSIVAAYNYIKDSKRFASLVRFDYSSKNQLWRFGMIRDLKNAKGVTCFCCDKENGMIIVAGADCSIRFMSLDLTKLSQVYKHSLPVTDMQLSPDSEALVSVSADGLLCLQFVGKFKNLSAVKLEDAGVILRLSLMFPFVLAILYFYLQLLFPDEKLDAIHRFFSFILHIFSKYTIRNYDL", "function": "Required for the formation of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein sar1.", "AFDB_id": "AF-Q10659-F1-model_v4" }, { "swissprot_id": "B2JMF6", "sequence": "MAARSIASLSLSFGLVSIPVKLYSATESSSDVRFNLLAPDGSRVRQQYISESSGAVVERSSMKKGYEFEKDRFVVFTADELKALEESASHVVEIVAFIPEKSIDPVYYDKAYYIAPDRRGGKPYSLLQQALAESGRCALAKWASKGKTRIVQVRPSADGLVFQQLLFADEVRSMKDLNIEHVDVSASELKLAMQIIEQGTEDHYDPAAYEDEEKKRILAAIDRKIEGKQVISNERADVPAEGGEVIDLMEALRASLRGGAKAKPAAAPRRKAPEPVAGMAEATRARKPAARAPKSPAEAPAKVRARK", "function": "With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.", "AFDB_id": "AF-B2JMF6-F1-model_v4" }, { "swissprot_id": "Q27367", "sequence": "MCCKCCGETQRKVWVFGLGSVFLLLGILIVVFWPGIADNLVEDGLTLKPGTDAYESWLEAPIPIYLSFYMFNWTNPEDIRNPDIKPNFVEMGPYTFLEKHKKENYTFYDNATVAYYERRTWFFDPERSNGTLDDMVTAAHAITATVADEMRDQRKIVKKIINFMLNHEGGKLYVTKPVGEWIFEGYQDNITDFLNLFNTTKIDIPYKRFGWLADRNESLTYDGLFTIHTGTDDISNLGRLTHWNGKSETGFYEMPCGIVNGTTGDMFPPKMNVNDEITIFATDACRFMNLRPRGTYENHGLTATKWVGTEETLDSGENYPNQACFCDEARFDECPKTGVVECKACRDKAPIYSSFPHFYLADQSYVDAVSGMKPEKEKHEFFLAVEPITGVPVQVHGRIQINMMIEPDDDFDIYRGVQKVLMPMFWFDQYAELSSELASKAKLAINLSSYGIIFGYSMIAFASVFLITGITLTVTKKWVRRTPEDEDILTN", "function": "Macrophage receptor for apoptotic cells.", "AFDB_id": "AF-Q27367-F1-model_v4" }, { "swissprot_id": "Q5YCC5", "sequence": "MSEFGAGAELPGWVTESRSRGEFFSPEESHAAAPAGFLQELPSYRSVLWRRAAAGDVQERWGNLRGIASAERREPQPDGGERGAIPLWELPFSIAEKRDSQQGDIKYSSGWNHWKRTSSKSWKKALKDIKELSSYMQLWRHDIHSIEGKFGTGIQSYFSFLRFLVLLNFLMFILMFSFVTLPAVISNYGIFNSSSTKISPNNTEPYCTVYTPSGNKGLVYFYTYLKDLLTGTGFLEVTVLFYGYYTIDAAWFSVLRYNLPLAYLLTTFAYLALSFVWIIKRSVERFRQHLVDDEDQFQSYCNKVFAGWDFCITDLNAARLKHRSLLYELQTNLEEERLKQKIAERTMKEKLQIYSLRIFINIIVIAVLSGCFYSIYRATVFSQENSSVSIRRNVMIANLLVQYLPSIVITSANFIAPQIFSFLIRFEDYSAAFEIRLTLIRCVFVRLANVGVLLFSLWSQIHCDNDQCKACGYDYELYPCWESAVGQEMYKLLIFDFMIIIAMTLFVDFPRKLLVTYCSWKLVQWWGLQEFGISDNVLEIIYGQTICWIGTFFSPLLPAIATIKYFIIFYIKKISLIHTRKPASRPIRASSSNFFFLAVLLIGLILAFVPLGVSIALISSSKACGPFRNFNTSWAIVPYTILEFPIGLQKFLYGIASEAFAVPFFVIACLFMFYFIALAGAHKRVVEQLREQLVTESRDKLFLLEKLSEAQKNSGKPQKARKLTSSWLLEPLDKG", "function": "Probable ion channel.", "AFDB_id": "AF-Q5YCC5-F1-model_v4" }, { "swissprot_id": "F4K2K3", "sequence": "MDRIAVRAKRKELGISCMLNTEVGAVLAVIRRPLSESYLSPQETDHCDSSVQQSLKSLRALIFNPQQDWRTIDPSVYLSPFLEVIQSDEIPASATAVALSSILKILKIEIFDEKTPGAKDAMNSIVSGITSCRLEKTDLVSEDAVMMRILQVLTGIMKHPSSELLEDQAVCTIVNTCFQVVQQSTGRGDLLQRNGRYTMHELIQIIFSRLPDFEVRGDEGGEDSESDTDEIDMSGGYGIRCCIDIFHFLCSLLNVVEVVENLEGTNVHTADEDVQIFALVLINSAIELSGDAIGQHPKLLRMVQDDLFHHLIHYGASSSPLVLSMICSCILNIYHFLRKFMRLQLEAFFSFVLLRVTAFTGFLPLQEVALEGLINFCRQPAFIVEAYVNYDCDPMCRNIFEETGKVLCRHTFPTSGPLTSIQIQAFEGLVILIHNIADNMDREEDEGNEEDDNNSNVIKPSPVEIHEYIPFWIDKPKEDFETWVDHIRVRKAQKRKLAIAANHFNRDEKKGLEYLKYNYLVSDPLDPMALASFFRFTPGLDKTMIGDYLGDPDELHLSVLRSFTHTFEFTGMNLDTALRTFLESFRLPGESQKIERMIEAFSERFYDQQSSDIFASKDTVHILCYSLIMLNTDQHNPQVRRKMTEDEFIRNNRAINAGNDLPKEYLSELFQSIATNAFALSTHSGPVEMNPNRWIELMNRTKTTQPFSLCQFDRRIGRDMFATIAGPSIAAVSAFFEHSDDDEVLHECVDAMISIARVAQYGLEDILDELIASFCKFTTLLNPYTTPEETLFAFSHDMKPRMATLAVFTLANTFGDSIRGGWRNIVDCLLKLRKLQLLPQSVIEFEINEENGGSESDMNNVSSQDTKFNRRQGSSLMGRFSHFLALDNVEESVALGMSEFEQNLKVIKQCRIGQIFSKSSVLPDVAVLNLGRSLIYAAAGKGQKFSTAIEEEETVKFCWDLIITIALSNVHRFNMFWPSYHEYLLNVANFPLFSPIPFVEKGLPGLFRVCIKILASNLQDHLPEELIFRSLTIMWKIDKEIIETCYDTITEFVSKIIIDYSANLHTNIGWKSVLQLLSLCGRHPETKEQAVDALIGLMSFNASHLSQSSYAYCIDCAFSFVALRNSSVEKNLKILDLMADSVTMLVKWYKTASTDTANSYSPASNTSSSSSMEENNLRGVNFVHHLFLKLSEAFRKTTLARREEIRNRAVTSLEKSFTMGHEDLGFTPSGCIYCIDHVIFPTIDDLHEKLLDYSRRENAEREMRSMEGTLKIAMKVLMNVFLVYLEQIVESAEFRTFWLGVLRRMDTCMKADLGEYGDNKLQEVVPELLTTMIGTMKEKEILVQKEDDDLWEITYIQIQWIAPALKDELFPDEEI", "function": "Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in vesicular protein sorting. Essential for pollen germination.", "AFDB_id": "AF-F4K2K3-F1-model_v4" }, { "swissprot_id": "P24228", "sequence": "MRFSRFIIGLTSCIAFSVQAANVDEYITQLPAGANLALMVQKVGASAPAIDYHSQQMALPASTQKVITALAALIQLGPDFRFTTTLETKGNVENGVLKGDLVARFGADPTLKRQDIRNMVATLKKSGVNQIDGNVLIDTSIFASHDKAPGWPWNDMTQCFSAPPAAAIVDRNCFSVSLYSAPKPGDMAFIRVASYYPVTMFSQVRTLPRGSAEAQYCELDVVPGDLNRFTLTGCLPQRSEPLPLAFAVQDGASYAGAILKDELKQAGITWSGTLLRQTQVNEPGTVVASKQSAPLHDLLKIMLKKSDNMIADTVFRMIGHARFNVPGTWRAGSDAVRQILRQQAGVDIGNTIIADGSGLSRHNLIAPATMMQVLQYIAQHDNELNFISMLPLAGYDGSLQYRAGLHQAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQYLSGYAVEPADQRNRRIPLVRFESRLYKDIYQNN", "function": "Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.", "AFDB_id": "AF-P24228-F1-model_v4" }, { "swissprot_id": "Q59971", "sequence": "MSGEAPRVAVDPFSCPMMTMQRKPEVHDAFREAGPVVEVNAPAGGPAWVITDDALAREVLADPRFVKDPDLAPTAWRGVDDGLDIPVPELRPFTLIAVDGEDHRRLRRIHAPAFNPRRLAERTDRIAAIADRLLTELADSSDRSGEPAELIGGFAYHFPLLVICELLGVPVTDPAMAREAVGVLKALGLGGPQSAGGDGTDPAGDVPDTSALESLLLEAVHAARRKDTRTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAEVLAGRLAADADGDAISRFVEEALRHHPPVPYTLWRFAATEVVIRGVRLPRGAPVLVDIEGTNTDGRHHDAPHAFHPDRPSRRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPQARLAVPYEELRWCRKGAQTARLTDLPVWLR", "function": "Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, DoxA catalyzes the C-13 hydroxylation of 13-deoxycarminomycin and 13-deoxydaunorubicin to yield 13-dihydrocarminomycin and 13-dihydrodaunorubicin, respectively, as well as the oxidation of these 13-dihydro-anthracyclines to their respective 13-keto forms, carminomycin and daunorubicin. In vitro, it also catalyzes the C-14 hydroxylation of daunorubicin to form doxorubicin (adriamycin), although this strain is not a doxorubicin producer. It is not able to accept anthracyclinones (aglycones) and anthracyclines with a 10-carbomethoxyl moiety. 13-oxidation of the anthracyclines possessing the 4-methoxy substitution is greatly favored. The anthracycline analog desacetyladriamycin can be oxidized to 10-hydroxydesacetyladriamycin. It can only use NADP. DoxA acts jointly with DauV.", "AFDB_id": "AF-Q59971-F1-model_v4" }, { "swissprot_id": "Q9C616", "sequence": "MELFPAQPDLSLQISPPNSKPSSTWQRRRSTTDQEDHEELDLGFWRRALDSRTSSLVSNSTSKTINHPFQDLSLSNISHHQQQQQHHHPQLLPNCNSSNILTSFQFPTQQQQQHLQGFLAHDLNTHLRPIRGIPLYHNPPPHHHPHRPPPPCFPFDPSSLIPSSSTSSPALTGNNNSFNTSSVSNPNYHNHHHQTLNRARFMPRFPAKRSMRAPRMRWTTTLHARFVHAVELLGGHERATPKSVLELMDVKDLTLAHVKSHLQMYRTVKTTDKAAASSGQSDVYENGSSGDNNSDDWMFDMNRKSRDSEELTNPLEKSNGLWTNSSGEARLHGKLIDNVAEIMLPSEKELDGKCSSYERISSEEMSSSSISGTSPFKPNLEFTLGRSH", "function": "Probable transcription factor that regulates lateral organ polarity. Promotes abaxial cell fate during lateral organd formation. Functions with KAN1 in the specification of polarity of the ovule outer integument.", "AFDB_id": "AF-Q9C616-F1-model_v4" }, { "swissprot_id": "Q9YEJ9", "sequence": "MAQAAVERRVFRLSVDEETVVAAGVGALSEAPRAAGGTAYIVHEEALSAEAARLARILEARGVEVLGAVAGGGERVKSLDWVTRLWDLMLQAGVERSTTVYIIGGGALLDAAGFAASTLMRGLSTVNIPSTTLAAFDAAAGGKTGVNLRGKNMVGTFHNPRMVLVEPGIVAGQPDEGYRDGFAELVKHVALSGDREPAASLLPQALARRPAPLARLAFWSLGYKMQVVAGDPRERGLRRILNLGHTIGHALEAASSYTLSHGRSVSIGLAGELELSRRLAGLPRGEAEDVLDMLSTAGLPLEPPPGLAGEAAGLVGLDKKREGGSIVMPLLERLGRPRLSRVPVETVSRLMVELWGGG", "function": "Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).", "AFDB_id": "AF-Q9YEJ9-F1-model_v4" }, { "swissprot_id": "Q2LTL4", "sequence": "MKRAFERMSMAIAIRNQQKKVKIDLRQIRRRVQKLLRLVDCREKEISLLFVDDEEIQEINQRYLGRNYPTNVISFSLSEGEFSSVNPDVLGDIVISVDTASRDAERGNIPVSDELDFLIIHGLLHILGYNHENNNPEETACMQKKEQELFFLLHGYPLDF", "function": "Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.", "AFDB_id": "AF-Q2LTL4-F1-model_v4" }, { "swissprot_id": "Q8IX15", "sequence": "MVRGWEPPPGLDCAISEGHKSEGTMPPNKEASGLSSSPAGLICLPPISEELQLVWTQAAQTSELDSNEHLLKTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYRRDQLHFKSLLSFTHHAGRPPEEVPPPPVPAPEQVGIGIGPPTLSKPTQTKGLKVEPEEPSQMPPLPQSHQKLKESLMTPGSGAFPYQSDFWQHLQSSGLSKEQAGRGPNQSHGIGTASWNHSTTVPQPQARDKPPPIALIASSCKEESASSVTPSSSSTSSSFQVLANGATAASKPLQPLGCVPQSVSPSEQALPPHLEPAWPQGLRHNSVPGRVGPTEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYQKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAIPTPPPSTRSLNERAETPPLPIPPPPPDIQPLERYWAAHQQLRETDIPQLSQASRLSTQQVLDWFDSRLPQPAEVVVCLDEEEEEEEEELPEDDEEEEEEEEEDDDDDDDDVIIQD", "function": "May function as a transcriptional regulator.", "AFDB_id": "AF-Q8IX15-F1-model_v4" }, { "swissprot_id": "B4U247", "sequence": "MTKLLLGFMGVGKTTVAAQLDEHFLDMDRLIEAKIGMSISAFFSYRGEAAFRKLESDTLQEVLALDNETIVSTGGGVVLSKANRELIRKNHKHNILLTASFEVLYDRLKKDRLCQRPLFLNHSKAEFYAIFQQRMALYEGLADKVINVEHRTPKEVAAIIANMS", "function": "Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.", "AFDB_id": "AF-B4U247-F1-model_v4" }, { "swissprot_id": "Q6E3D4", "sequence": "MSQEEVPGEIPGDIAIEKAENTVQDDVEAKNTSETKKTIPPMLNVEKVDVAAVGEKSPAPVSVYDLFKKYQKPDVKSDSEDMNIGFDQLTTDEKNGFLRKLQMLTVGNKKTLKVPGESTPSPASRLLKKFVPSRRPSTENKSCESPSRFSLFGKSNKKAPELERPMNGGQPRKKSARRLNFGKEIEERTETDFQNNRVVAAMTREYEKIVTLKGVPVPINKPPRQQGPRGSLETPTDSPAKTETSSISKSYGSDYQSSRDRYTSINEDSLTKKRISTPNRGQGLSNRDNATWHGELPPRDYTSPTFSRKIFVGGVPWDITEAALKDSFGEFGSCAVEWPGHEARYRNAQSNTASLNLRNQSKYTGQAATGYVYMIFEDERAVASLLHECSQEIGGAGEWYFKIRAQRSKSTEIRQVQIIPWVTSDSMFCEDESLLEVGIEPKRTVFVGALHGMMTAQVLHSIMEDCFGSVECVQLDTDKFKYPIGSGRVTFREHGAYFKAIEMGYLHVHTSKFRKRVQIDPFLESTNCMVCTTELAHCFCRNRNCFKYYCHTCWAVDHGHGHDGEVHVPVIVPSSASKAFSGPNRRSHLSSNSPSKPASLMSSSNSQVAHMVSPAYPVLVGAPAQNLSALYGYIQNSQQMMITPAAVYEPPMTPSPNEMKRRSFPEFQPQPTVFFNSTPMMTPQKGVPCSDGSAVPAYYANSAAFLTPPSSYYNSPSHSTSSNLSPQQPQQYYGANLYYGYMPQMSYDGGPNQSAMHLPHTPNYQQ", "function": "Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs.", "AFDB_id": "AF-Q6E3D4-F1-model_v4" }, { "swissprot_id": "Q92275", "sequence": "MLDPLYPLFPIFAFLGFVLAILPLPWHLQAWNSGTCFFMMWTALGCLNQFINSVAWADDAMNKAPVWCEISIRILMGASVGIPASSLCIIRRLYYIAKVRAVSKTRAEKMRAILVDALICVLFPLVYIALQYIVQGHRFNILENIGCYPAVTNTPVTYVVSYVWPVLLGLISATYGVMALLQFNKHRLQFSQFLHTHSTLSASRYLRLMALALTEMMCTMPLGIFVIVLNSKTENIQPWVSLAVTHYGFGRIDQVPAIVWRSQHLIVVCNELTRWCAPVSAFIFFFYFGFAEEARRNYAAAWRRVCRALGLPERVPSLPTTKKPFSSSDNKGSGFAEKFAAKAKGFSNFNVKDFTSEFTSKAHDFTSKAKQYTLPRPMPQTLSSSGFSSSDSTRFGSSVDGKELPSPTTKEFSSPIPIHLSGMQTLASFDSNKDLPSPPAYDIEAQYGPYNIDNRVSYHIADTGVRASYPMGVAYSSDSEHRRIVPHHSTVPHHSTADEPASPALPDTPSSCSSSATFSTLQSRDFIVLPSSADVTRRDSGSSAGGVASTSRPTRAGPPRLPSLSQLFGISSMRGQEGDVEAQGEEMAADVDVSEMVLDTLAPASIIAATTTAGAPATTTPDRGEPDVPTSPRTHRASV", "function": "Receptor for the BAP1 pheromone, a prenylated mating factor. Has a role in the initiation of B-regulated nuclear migration.", "AFDB_id": "AF-Q92275-F1-model_v4" }, { "swissprot_id": "P07363", "sequence": "MSMDISDFYQTFFDEADELLADMEQHLLVLQPEAPDAEQLNAIFRAAHSIKGGAGTFGFSVLQETTHLMENLLDEARRGEMQLNTDIINLFLETKDIMQEQLDAYKQSQEPDAASFDYICQALRQLALEAKGETPSAVTRLSVVAKSEPQDEQSRSQSPRRIILSRLKAGEVDLLEEELGHLTTLTDVVKGADSLSAILPGDIAEDDITAVLCFVIEADQITFETVEVSPKISTPPVLKLAAEQAPTGRVEREKTTRSNESTSIRVAVEKVDQLINLVGELVITQSMLAQRSSELDPVNHGDLITSMGQLQRNARDLQESVMSIRMMPMEYVFSRYPRLVRDLAGKLGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLDHGIELPEKRLAAGKNSVGNLILSAEHQGGNICIEVTDDGAGLNRERILAKAASQGLTVSENMSDDEVAMLIFAPGFSTAEQVTDVSGRGVGMDVVKRNIQKMGGHVEIQSKQGTGTTIRILLPLTLAILDGMSVRVADEVFILPLNAVMESLQPREADLHPLAGGERVLEVRGEYLPIVELWKVFNVAGAKTEATQGIVVILQSGGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAATILGDGSVALIVDVSALQAINREQRMANTAA", "function": "Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.", "AFDB_id": "AF-P07363-F1-model_v4" }, { "swissprot_id": "Q9D8C3", "sequence": "MKRAFVTVGTTSFDELVARVVANDCVQILESLGYNHLVLQVGRGTVVPKPFRTESFTLDVYRYKDSLKEDLQQADLVISHAGAGSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEGHLFYCTCRVLSCPAPVSLLLVLLGSAKILQQLPSATLSCFGYLPTQAPVLVATAYSYLHSVFSSFPPLSTFLIIPCTMQKGWKKYCGQKSLNEASMDEYLGSLGLFRKVVAKDASCLFRAISEQLFHSQIHHLQIRRACVSYMKENQQAFESYVEGSFEKYLERLGDPKESAGQLELKALSLIYNRDFIIYRYPGKPPTQVTDNGFEDKIILCYSNNGHYDSVYSKEFQSTAGICQAILYELLYKDVFVVDEETLKTAVDLFRSGSRRNKHHALTASVEGSSDQKSSTEDRTEEAAACSSAASTPEGNKQGTERQKVPESPSKMLFPYKVLKALDPEIYRNVEFDAWLDSRKELQKSECVEYGGRYYFLGDKCQVCMESGGKYYNAHIQEIDNDKSSVVVFIEEFAERHSIPLAHVRPVNQVALLPSWNAIPIRNGRGYPTITGGYFPEIVMTDMNMKQRKKMFKKFRGKEIYMTMAYSRGDPLVPSRIQHSMHYGHDPLLYYSQTAGHILSSQHFYPQHSSQRQGRGYGMPRDSSHLISKQNLPNPKVGFCSGSGRKCCQSYDNVSYRSRSFRRSHRQMHCMNKGCQYGFAPENGVEETVTFYALEEGNETAYSTLPNNGGPTTMVPATSGYCVARQGYNSCKPPLNSGDSNDHCDNGGYHGDYLYSSEQGYETSSVYTTTVSTANLSLQDSGPSSVPQDTVTSYNYPQKVLENSAAIAVSWASHVPVPVIPNCAGDNEALRTSDISSQNAIQPGFVPPPAQGSPAYLEPSAAGAAGAAAAAAAAAAPVATPVAAPLPLPPPLPPPPPATLEAGDASGFPLPPPPPPPPPPPPPYSYDPSGSDLPQDTKVLQYYFNLGLQCYHHNYWHPMVYMPHVQQQLQPQPQPQPQPQPQPQPQPQPQPQQPQQQQPPPQQQQQQQEQVHGESYPDCTEQPLVDQSAPQVYSDVVREDGTQADVSTNDTFPIADAVPLPHGAVYYPVMTDPYGSPLLGFDSYVPVASDYSSIAMWHPVNAACGASAQIHGAMNPGPIGYMLLPNSPHYTPQN", "function": "May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway (By. similarity).", "AFDB_id": "AF-Q9D8C3-F1-model_v4" }, { "swissprot_id": "Q27018", "sequence": "SLILLVAVQALTEEDLQLLRQTSAECKTESGASEAVIKKARKGDLEDDPKLKMQLLCIFKALEIVAESGEIEADTFKEKLTRVTNDDEESEKIVEKCTVTEDTPEDTAFEVTKCVLKDKPNFFGDLFV", "function": "May be a carrier protein for lipids.", "AFDB_id": "AF-Q27018-F1-model_v4" }, { "swissprot_id": "Q9R9U8", "sequence": "MNCSLRCRFFLILVMAGFSFFVALFGMRLMHKMAEFAYFEREHVVALSKVYYELHKKEINISFIVGQVQRARRQTTAVNSLWKGDKALLRLLGKGLILELSEASEIKLGLLERYASSIYKDGLNPGHIEEMKRLVSWPYTNSNRFGIEIADISKRVKAYVYFLVVSINCLFFVVIFLLMKKTRSSIDEIVHVMNDMSRGDLTYRTIPSNDEVGKMQSSIIAMGAGVSALIESIKHIQGDLFNSAGEALNISQSTSNDICDQAGKIDEFVSALSQISFAITETSNAANKSSALSSEGRQLAVHGQKAIETAVSSINALSQRVNDSHVAIKCIEADIAKIGKIIEIIDQITDQTNLLALNAAIEAAHAGEAGKGFAVVADEVRSLAQRTNNSTYEIQAMIASLNKGIFFALGVMGDCVVESKNSVNAASEASRSIEKIVDSVSQVMLQIAQVATASEEQSAVVKDMLDNANIIREIAAGVELGSRRISEVNTHR", "function": "Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.", "AFDB_id": "AF-Q9R9U8-F1-model_v4" }, { "swissprot_id": "Q7UNR2", "sequence": "MVVGQRERKRRCIRGEPLMNDTTWVLDGGRLIDPANGIDRIARLVLHEGKVHSIDTPDGDVPPDAGRLDVTGKIVAPGLVDLATELREPGSEEDETIQTGSNAALAGGYTTVLCCSSTKPLMDSAASVQLVRQIAQRVDGVRVLPIACLSKGRQAEQMAELGILAAAGAAGFSDTPRPMPNDALLKRALDYCRMFDLPIFDRPEVPELADGGVMHDGQIGLILGLKGLPTEAEDLAVARDVRLAEATKGRLHVGPVSTMGSIDMIGRVKSRGIHISASVCPHNLFGSDELLRSYDSRYKVHPPMRSPSHVEALRNAVAEGVIDAIESGHMPRAQEKKANDLDLAPFGASALETTLAAIATDLVETKILPWSRAIECLSTAPARIAGVKGGTLSVGANADVTVIDPLNAWSVEAKEFRSRCHSSPMTGRTLTARVTHTLVGGRLKFELHPTVASAAS", "function": "Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.", "AFDB_id": "AF-Q7UNR2-F1-model_v4" }, { "swissprot_id": "P9WGU6", "sequence": "MGVPSPVRRVCVTVGALVALACMVLAGCTVSPPPAPQSTDTPRSTPPPPRRPTQIIMGIDWIGPGFNPHLLSDLSPVNAAISALVLPSAFRPIPDPNTPTGSRWEMDPTLLVSADVTNNHPFTVTYKIRPEAQWTDNAPIAADDFWYLWQQMVTQPGVVDPAGYHLITSVQSLEGGKQAVVTFAQPYPAWRELFTDILPAHIVKDIPGGFASGLARALPVTGGQFRVENIDPQRDEILIARNDRYWGPPSKPGIILFRRAGAPAALADSVRNGDTQVAQVHGGSAAFAQLSAIPDVRTARIVTPRVMQFTLRANVPKLADTQVRKAILGLLDVDLLAAVGAGTDNTVTLDQAQIRSPSDPGYVPTAPPAMSSAAALGLLEASGFQVDTNTSVSPAPSVPDSTTTSVSTGPPEVIRGRISKDGEQLTLVIGVAANDPTSVAVANTAADQLRDVGIAATVLALDPVTLYHDALNDNRVDAIVGWRQAGGNLATLLASRYGCPALQATTVPAANAPTTAPSAPIGPTPSAAPDTATPPPTAPRRPSDPGALVKAPSNLTGICDRSIQSNIDAALNGTKNINDVITAVEPRLWNMSTVLPILQDTTIVAAGPSVQNVSLSGAVPVGIVGDAGQWVKTGQ", "function": "May directly or indirectly regulate the accessibility of the key branch point intermediate, monoacyl phosphatidylinositol tetramannoside (AcPIM4), to the elongating alpha-1,6 mannosyltransferases which could regulate the lipoarabinomannans (LAMs) biosynthesis.", "AFDB_id": "AF-P9WGU6-F1-model_v4" }, { "swissprot_id": "A4J716", "sequence": "MTSSRFGRLAPGVRDVLPAEAHLMRGLKEKFTKLVETWGYKEVVTPTFEYMENLASEELQEEKFFKFLDRQGHLMALRPDMTRPMARLVATRMKGITPPLRLFYLANVFNYEQPQVGRQREFYQAGVELMGPSSPEADAEVVAMVAEYLMQTGLADFQISIGNVGIFHGLVKQLGLPKEVAQELKEALGNKDFVKVEEILGSHAATPEEARRTLDLIELRGGPEILDRAFGLAQPGPAADAIDNLRQLYWGLTCYGVERHITLDLGLLRGLDYYTGLVFEGYTVAMGFPICGGGRYNQLLAKFGLPMPATGFAVNLERVLVALERLQGPPREPVPDVLVAWEDNSLANALQCVKELRYQGLKVVTAMFEYPPAKAKAEARSLGASRVIYFDKEGKSEELSL", "function": "Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.", "AFDB_id": "AF-A4J716-F1-model_v4" }, { "swissprot_id": "B0JFB8", "sequence": "MKAVITLLFLACILVVTYGDLICGTNYCKDHPCTSPIARASCRSPATYRANHSGKCACCPACVTLLRERAACKTYSKEIGETPSAVCQEPLKCLNGVCTKVTPRR", "function": "Inhibits proteases from the fungi A.oryzae and R.oryzae, trypsin and chymotrypsin. Does not inhibit protease from the bacterium B.licheniformis or papain.", "AFDB_id": "AF-B0JFB8-F1-model_v4" }, { "swissprot_id": "P52127", "sequence": "MESNDSGGVAAKHGFLFQDCVAAYHVTRMLRDKTIRSVRCEVTDDIDIVSDGYIDFVQVKSTGKTRWNISDIVQNSKGADKKTIPCSSILHKSMQCESDLSLGRRYSIVTEEKVNKTLEYLTISPNARLDKPGRQELIDDLNKRTDNFLTDSGISVSDWIDAATWEVFSSLRELELLGIKNIRLASQDLHGVILSSETVAEDIWCRILDTVTRKGEHSRRIHSADDKSYLRPDLLEWFKQRVEDDQSRSGRKIYVKRDLPHILTPFRAPMASVCAKRKGQVLHQQYSLKKYRYKHIADNVCQWLDEVFLRPKEMSDIHKLTFIEKRERLKNSVFKSLHDVSEFLGRVLLHATIRQHHESQPIPCMLYVEKAGAEKILENVHIVRRDPEGDQLWIGFSELVTDINIAVRLPEIRDQLYEDISDCIDTARKKILDIKDDNYLLRHDIDEILDGSQPFDAHLDRFTFVLFVGYDSNLLTEPETPGFEDDLEKETAVLFEKFAADLIEDSPFANLCIHVFIYPAPSLERLTQLVDEKVREVV", "function": "Part of an antiviral system composed of AbpA and AbpB; when both are expressed from a plasmid they confer resistance to phages T2, T4, T7 and lambda but not RB32 or RB69. Resistance is temperature dependent, it can be seen at 30 degrees Celsius but not at 37 or 42 degrees Celsius. The system impairs phage but not bacterial DNA synthesis (shown for T4, T7 and lambda). Partially suppressed by mutations in T4 gene 41, a replicative helicase.", "AFDB_id": "AF-P52127-F1-model_v4" }, { "swissprot_id": "P31378", "sequence": "MQKISKYSSMAILRKRPLVKTETGPESELLPEKRTKIKQEEVVPQPVDIDWVKSLPNKQYFEWIVVRNGNVPNRWATPLDPSILVTPASTKVPYKFQETYARMRVLRSKILAPVDIIGGSSIPVTVASKCGISKEQISPRDYRLQVLLGVMLSSQTKDEVTAMAMLNIMRYCIDELHSEEGMTLEAVLQINETKLDELIHSVGFHTRKAKYILSTCKILQDQFSSDVPATINELLGLPGVGPKMAYLTLQKAWGKIEGICVDVHVDRLTKLWKWVDAQKCKTPDQTRTQLQNWLPKGLWTEINGLLVGFGQIITKSRNLGDMLQFLPPDDPRSSLDWDLQSQLYKEIQQNIMSYPKWVKYLEGKRELNVEAEINVKHEEKTVEETMVKLENDISVKVED", "function": "Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage and cytosine photoproducts generated by UV irradiation as well as abasic sites. Has also 8-oxoguanine DNA glycosylase activity. The AP lyase can incise AP sites opposite all four bases. May also play a role in the regulation of mtDNA copy number by introducing a double-stranded break (DSB) at the mtDNA replication origin ori5, initiating the rolling-circle mtDNA replication.", "AFDB_id": "AF-P31378-F1-model_v4" }, { "swissprot_id": "Q81H98", "sequence": "MKYPYSFEVLTNGKLVMRLPQEIKLMETFLGVEVSAFGDWILEEIHSVLNGKENYVVVNGNICGLEIRKDTTTVLDNLAEDGKGDFCEIETIELVDLIHIWQDKQKEFKKGKNKELK", "function": "Immunity component of an LXG toxin-immunity module. Neutralizes the RNase activity of cognate toxin BC_0920. Probably does not have immunity protein activity on other toxins with the LXG domain.", "AFDB_id": "AF-Q81H98-F1-model_v4" }, { "swissprot_id": "P0DJJ3", "sequence": "MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGMQPSPHEPPYHSKAECAREGGKKASKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDVLKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRRSTPTPELTSKKPLDDTLALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMESPKLARPFPTGTPPPLPPKAVPATPPRTGSPLTVATGNDQAATEAKIEKLPSISDLDSIFGPVLSPKSVAVNTEEKWVHFSDASPEHVTPELTPREKVVTPPAASDIPADSPAPGPPGPPGSAGPPGPPGPRHVPSPLNLEEVQKKVAEQTFIKDDYLETLSSPKECGLGQRATPPPPPPPTYRTVVSSPGPGSGSGTGTASGASSPARPATPLVPCSSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRGKFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINSSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPGSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN", "function": "May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.", "AFDB_id": "AF-P0DJJ3-F1-model_v4" }, { "swissprot_id": "Q6C233", "sequence": "MPTGYHNFCDDELDESINFNYNRKPSQPKDYDDDSRTSGRTTPKRARGGRGRGSGDRGGRGGSRGRGGNGGSSRGGKKNGWRDEKPSLLSSILNSRQHASENREHMFNKSLRGAEFITFIKSAEVYDPSKLLKDVGVTVEEANVVNEVEDIHIIVPEVIPEVQDVTGADAQLEDQESEDEEVVTTITETYADDGDNQEDDDDEMLVDGNGQLVDDYDDDEDDDDEDDEIDEEVDDDLIADENAVDVSTLQDAINEVANDTINDDRKEEDPSEGSEADDEEDEAAEFVMDTEGDPDMVDMEFMETDFAYLNKKKRAEKSRTPLTSSTAVISDRPVASVSADTTLVGSVASKKRHNADPRAVDIPEYNSDIDPEVLKDYIESIKNEDEGSDAENIDWIRSALGTQLGGTEQYYVDSDDSENDDFDDDDEDDEEEYEWPENGTVGCIRNIVATRAASQGYQFMVEHTLDADMEEWWNEDLIRDSVAEHLGVSVSELPDEAYRWYVTRLGGDIEDPDLSEEGINYSDYYDDSDEDEKAREASEMDSLIQSLIDDEVDDRKALMDHGYTPPMTKSRGKNQVPNFGVNDPELQAQLEKHWVNSRAAKRAKREQRQAMRKQGMFTKEFKQGGIIPLHAKYPILMTVEEARKEIEIFINAPNKPMVLDFPPMGAEFRSVLKKLSACYHLKPDIHGVQKSKHVSMLRTSRTSCHNNNYIQKFHDKFPKKFKLVIRNAKYSTEQYLYETKHQKGSKRSAVRVHNREGEIVGHEAPAIDDSNIGRLLLQKMGWTTGEGLGAQSRGISEPIIAKVKISKRGIGA", "function": "May be involved in splicing.", "AFDB_id": "AF-Q6C233-F1-model_v4" }, { "swissprot_id": "Q84MD2", "sequence": "MGMSPLTVKKLGFIFMIVSASALSVSFAGRPSIFVHKKINLREEMVERSMHEHERLLRMNTKDYGNNSPSPRLERPPFKLIPN", "function": "Peptide hormone required for contiguous Casparian strip diffusion barrier formation in roots via the regulation of CASPs protein expression and distribution in a GSO1-GSO2 signaling pathway. The Casparian strip is required for ion homeostasis (e.g. iron and potassium ions).", "AFDB_id": "AF-Q84MD2-F1-model_v4" }, { "swissprot_id": "Q9NF14", "sequence": "MSDRHLYGSDHSYLSSKPSCSSCRRQSSTSQKNECMTNPGSIVLTQRWTVCNFESLLKLSRPGSCLRSTVFKDDAVPDACWQLCLYPGGKREENANNVSLFLKMSATSPSKEVVLKAEYRFYFLDDNDEPKFSNVNVGEFHAKPPKGGHSWGLRNIPTQKVQNSIRQDKSLVISCHIELIPDASKVPCKRVPITPSIEMPFAQIPRAHVESELEMLASGDGTDMTIVAGPLDGEREQFRVHAYKLRAHSDVFQMMLSHTEMRENQEKRIEILDFSPTSVRAMVEFIYAGVIKSDIDVYQAVDVMQIAEKYQILALKMTCEQHLLDRLNVNNVLECITHAERYNTDVLYDACVDFAIHNRQHVMALTSWRNFISDEPVLASNLLEKMVKSNDNSSPPVKKPRV", "function": "Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q9NF14-F1-model_v4" }, { "swissprot_id": "Q7UR74", "sequence": "MCDQLAFASQRKPYQHMDLRHHVRDIPDYPKPGILFRDITPLLAHPEALTASVEEMAKPFLDQKIDVVAAAEARGFIFGTPLAMRLNAGFVPIRKPGKLPFDLHSFAYELEYGSDELQIHVDGIKPGQRVLIVDDLLATGGTVEACLRLLEKCDAEIVGCSFLIHLVALGGEARLSPYHVHSVLEYGGDDAEDELSIQNRPPGPSV", "function": "Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.", "AFDB_id": "AF-Q7UR74-F1-model_v4" }, { "swissprot_id": "Q4P9E5", "sequence": "MSAEPSVQTTSSSGPTELRSAPSYAGSWTKLTPPLTPWVVSLLSDLGFGQMTPVQASTIPLFVSHKDVVVEAVTGSGKTLAFVIPVLEMLARRTTRLKKDEVGALIVSPTRELAEQIYKVLVMFLDAQNHAHVQAQQQQDQDEQDEQDEQEAQSDSDTDPDASTALNNKRKSSNHLVARKNMISGAQLVVGGSKCTPLDDYRQLRDSGADILVGTPGRLEELLSKKGVKKSSLEVLVLDEADRLLDLGFTENLRRILSLLPKQRRTGLFSATMTDALSELVRIGLRNPVRVVVKVEAKHKTSSSIDDSRRTPATLQNLYQLCRAQNKLAQLARIVLFESSQNAISGGARKLIVYFSTCAQVNYFYSVFSQVSILRQHRVKLYALHGKQTPSKRKSMFDTFVASTALDSGASGASVLFCTDVAARGLDLPDVDVVVQYDPPTDPKVFSHRCGRTARAGRNGRAIVMLHTGREQDFVSYMRVKRIPLSPYPYLSSTLHGILEPAEDDASAHDLELSIRDLAKTDREIFELSIRAYVSYVRAYTKHEMSYIFRINELDLAGVARAFALIRLPSMPELKSRQSAGTLIYNQEPIDFSSIPFKDKAKQRIRLAKLSGDQAKPPARIKASVDDAAQLQDDQCDSHDSDDAHPNSSATRAKNKRKLEREKGAWSAQKERKQARLANREKRARKRTFLKTQAAESSSNAKHEPPQDDHDEHDWNDDYRKLQKDKRQQRQRNKADRANSDNDDAMHFNSDSDAAAANADAEPFFVI", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.", "AFDB_id": "AF-Q4P9E5-F1-model_v4" }, { "swissprot_id": "Q8GXN2", "sequence": "MDQKVRQFEVCTQDGSVDRHGNPAIRANTGKWLTAILILVNQGLATLAFFGVGVNLVLFLTRVMGQDNAEAANNVSKWTGTVYIFSLLGAFLSDSYWGRYKTCAIFQASFVAGLMMLSLSTGALLLEPSGCGVEDSPCKPHSTFKTVLFYLSVYLIALGYGGYQPNIATFGADQFDAEDSVEGHSKIAFFSYFYLALNLGSLFSNTVLGYFEDQGEWPLGFWASAGSAFAGLVLFLIGTPKYRHFTPRESPWSRFCQVLVAATRKAKIDVHHEELNLYDSETQYTGDKKILHTKGFRFLDRAAIVTPDDEAEKVESGSKYDPWRLCSVTQVEEVKCVLRLLPIWLCTILYSVVFTQMASLFVVQGAAMKTNIKNFRIPASSMSSFDILSVAFFIFAYRRFLDPLFARLNKTERNKGLTELQRMGIGLVIAIMAMISAGIVEIHRLKNKEPESATSISSSSTLSIFWQVPQYMLIGASEVFMYVGQLEFFNSQAPTGLKSFASALCMASISLGNYVSSLLVSIVMKISTTDDVHGWIPENLNKGHLERFYFLLAGLTAADFVVYLICAKWYKYIKSEASFSESVTEEEEV", "function": "Low-affinity nitrate transporter. Involved in nitrate removal from xylem sap. Not involved in oligopeptides transport.", "AFDB_id": "AF-Q8GXN2-F1-model_v4" }, { "swissprot_id": "B1GZN4", "sequence": "MRKVQEIEDLLAPVAAREKIEIVDVQYSKKAGDWVARIFIDKDSGVTISDCENISCIFGAFLDESDILKDSYVLEISSPGFKRVLKSEKSFRRFIGSKTRIRTFKPINNQRNFLGTLLNFDDGRIKINDVTNGVVEIEFSDIRKANIEADI", "function": "Required for maturation of 30S ribosomal subunits.", "AFDB_id": "AF-B1GZN4-F1-model_v4" }, { "swissprot_id": "Q8C0E3", "sequence": "MDGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGTGGSGGPARCPLCQEPFPDGLQLRKNHTLSELLQLRQGSVPGPMSAPASGSTRGATPEPSAPSAPPPAPEPSAPCAPEQWPAGEEPVRCDACPEGAALPAALSCLSCLASFCSAHLAPHERSPALRGHRLVPPLRRLEESLCPRHLRPLERYCRVERVCLCEACATQDHRGHELVPLEQERALQEVEQSKVLSAAEDRMDELGAGIAQSRRTVALIKSAAVAERERVSQMFAEATATLQSFQNEVMGFIEEGEATMLGRSQGDLRRQEEQRSRLSKARHNLGQVPEADSVSFLQELLALRLALEEGCGPGPGPPRELSFTKSSQVVKAVRDTLISACASQWEQLRGLGSNEDGLQKLGSEDVESQDPDSTSLLESEAPRDYFLKFAYIVDLDSDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWVSVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRGFSVWFCGLEAPLPHAFSPTVGVCLEYADHALAFYAVRDGKLSLLRRLKASRPRRSGALASPTDPFQSRLDSHFSGLFNHRLKPAFFLESVDAHLQIGPLKKSCITVLKRR", "function": "E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD.", "AFDB_id": "AF-Q8C0E3-F1-model_v4" }, { "swissprot_id": "Q8MPQ7", "sequence": "MGKKDKNVSVEEEVDEAEIEKLAAENANKPAPQLTKEDLDAMDDAEPGTSRLALIGKMIKKVSIGTDISNISMPGSFILAKSTLSYFSDNFSSFFGELLKANKIDNELERMLQVQRYLFTTLKETEDTTRKPLNPILGETWQANIHVKDGDGNDVTDNYFFAEQISHHPPISSSTVYNKKEGVNCTFCLPVRSQFMGTYVKISFEGESHITFEKYDEKFTFVAPPMAIRIFRSFSEYVGKGILKSDKNDYLIKSTYTSKPLFGGVYNGFESKVYKGKEKLYKIKGTWSGDMKITNLKTNETTPFFTRPTESAKVVFPDDGNTLPTDSSVVWKGVFDASKKDDVKGMSQEKVKVEEEQRKLAHHRKNADEWKPVHFNKIDGRWQLVNLKD", "function": "May play a role in the regulation of the slug-fruiting body switch.", "AFDB_id": "AF-Q8MPQ7-F1-model_v4" }, { "swissprot_id": "P17906", "sequence": "MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVADGLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQFTYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNVPDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS", "function": "Negative regulator of sigma-B activity. Dephosphorylates RsbS. Plays a role both in maintaining low sigma-B activity during growth and in reestablishing prestress sigma-B activity after induction. Could have a negative feedback role by indirectly communicating sigma-B protein levels.", "AFDB_id": "AF-P17906-F1-model_v4" }, { "swissprot_id": "P38092", "sequence": "MEALLQQSRAMCPFLKRSSPNTLRSLATATRPSTSPGGGTMTNLQRIARRCPVMSKALAVQSARMTGTKRFTSSAAGVPGAGAGTPKPTRGSPGKRALHSTGGNGANMSTEFHKGAQQIHPGLSNATRSHVGASATVSGPTPRAPVAAPFDYDAFYNAELQKKHQDKSYRYFNNINRLAQEFPRAHTASKDEKVTVWCSNDYLGMGRNPEVLATMHKTLDTYGAGAGGTRNISGHNQHAVSLENTLAKLHGKEAALVFSSCFVANDATLATLGSKMPDCVILSDSLNHASMIQGIRHSGAKKMVFKHNDLVDLETKLASLPLHVPKIIAFESVYSMCGSIAPIEAICDLADKYGAITFLDEVHAVGMYGPHGAGVAEHLDYEIYASQDTANPLSTKGTVMDRINIITGTLGKAYGCVGGYIAGSAALVDTIRSLAPGFIFTTSLPPATMAGADTAIRYQARHQQDRILQQLHTRAVKQSFKDLDIPVIPNPSHIVPLLVGDAELAKQASDKLLEEHGIYVQAINYPTVPRGEERLRITPTPGHTQELRDHLVEAVNTVWNDLGIKRASDWKAMGGFVGVGVEAAELENQPIWTDAQLNMRPDETLEAAVEREFQAAVPGMKAGGAKAKPVGSIAANPIGASIPVAAAA", "function": "Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.", "AFDB_id": "AF-P38092-F1-model_v4" }, { "swissprot_id": "Q2EEW4", "sequence": "MPRDLFSDALTRLRNALRVNKQTVIIPFSNLNYSFSNILLEEHLLEKKTILSKKYIKLEGLKFYNKKSDHTLFNFFKNCQRLSKPSNRLYIKAGDIPLIDNGLGFVILSTSYGLMTGKKARALNIGGELLCQFNFQ", "function": "One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.", "AFDB_id": "AF-Q2EEW4-F1-model_v4" }, { "swissprot_id": "Q9HTB6", "sequence": "MTQRLFVTGLSGFVGKHLQAYLAAAHTPWALLPVPHRYDLLEPDSLGDLWPELPDAVIHLAGQTYVPEAFRDPARTLQINLLGTLNLLQALKARGFSGTFLYISSGDVYGQVAEAALPIHEELIPHPRNPYAVSKLAAESLCLQWGITEGWRVLVARPFNHIGPGQKDSFVIASAARQIARMKQGLQANRLEVGDIDVSRDFLDVQDVLSAYLRLLSHGEAGAVYNVCSGQEQKIRELIELLADIAQVELEIVQDPARMRRAEQRRVRGSHARLHDTTGWKPEITIKQSLRAILSDWESRVREE", "function": "Reductase that catalyzes the conversion of GDP-6-deoxy-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (GDP-D-rhamnose).", "AFDB_id": "AF-Q9HTB6-F1-model_v4" }, { "swissprot_id": "Q2LXE3", "sequence": "MPLSDNLNLLWSSLIVAELVKNGLDTFFISPGNRNAPLISALIHEERSVKKICVDERAAGYRALGHAKAAGRPGVLVCTSGTAPANYYPAVIEAFRDEIPLVILSADRPPELIGSDANQTIVQPDLYGRYCRDSLLIPCPSADYPLEALLARIDSLIARPVGPVHINCAFRDPLVPGIPDSRPIPDELLATAGRLYAREGAYTTYPSPGTLHTGLEDVEAILNRTARGLIVIGRLDGPRDAPALEELAKKLGWPVFCDIASSMKGRIPSDRQIFSLDHPEALRLVSAYAPETILQFGSGLVSKHYFASLLPHSEATVIQISPRAGLRDPAHRVNVRLSMPAFAFVEGLHLQENPSLDATACCLFLDSLETLYQALQRRIPEETLSFSRIASDLLGAVPDGEGLFLGNSLVIRAFDKFRSPFPRKISVISNRGVSGIEGNIATSVGFAEASRRRVTAVIGDISFLHDLNSLLLLAQSATPVVLIIINNGGGRIFERLPIRDFPEILEPYMTTPHGMTFDLLAAQFDLPYFRAATPDELRKAYESALDAERSAVLEVTLDPEEDLRTFQTFQNVRLP", "function": "Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).", "AFDB_id": "AF-Q2LXE3-F1-model_v4" }, { "swissprot_id": "Q8K1M5", "sequence": "MDLSALASSREVRGPGPGAPVNRPLLPLLLLLLLLPLPASAWYKHVASPRYHTVGRASGLLMGLRRSPYLWRRALGGAAGPLVGLPGQMARSALLLPSPGQELWEVRSRSSPAGLPVHATRSLRDLEGAGQPEQSLSFQSWTSAEPAARAFGETLRAQPWFLQQIIFADPVRLDDRLKNRWRPRA", "function": "Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release.", "AFDB_id": "AF-Q8K1M5-F1-model_v4" }, { "swissprot_id": "P16536", "sequence": "MFSFIDDIPSFEQIKARVRDDLRKHGWEKRWNDSRLVQKSRELLNDEELKIDPATWIWKRMPSREEVAARRQRDFETVWKYRYRLGGFASGALLALALAGIFSTGNFGGSSDAGNRPSVVYPIE", "function": "Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.", "AFDB_id": "AF-P16536-F1-model_v4" }, { "swissprot_id": "A4I9M7", "sequence": "MKLCGVRSSGVSLTRSSDFPRFRAAHHGGAHTATRHQSLCGRRLDSYMGAGKRWCFRPLLAEPRRYSNASSAFTTDGATAPAHGEGLYVSHYAMPEDARRLVGTPQLLPRNPAEEVAFKKNLIRSFPQACIRNVSVVAHVDHGKTTLSDAMLRFSNLLPADGATGTFTDRLKVEKERGITIKAQTCSVLLTLRETGTQYLVNLIDTPGHVDFQYEVSRSLCASEGAALLVDVRQGVEAQTMAQFYAALEQNLTILPVLTKMDSVMSDAEVEKTLLQLEDSTGLLSREVILTSAKSKRGIEQLFQHIIDKVPPPCGREGFSDMKQLPAMHPGSADRKKVEKELVPLRALLFDCWTSESSGMADGAASAPVSTASSVSSGTAPASGGQSVAKDGIYGLIRVMDGTVTPGTTVTFFHSGKKHEVREVGIIHPTLHPTAALTAGMVGFVFFPGLLKKDVFIGDTLCTLPTRKHTMRVVATGSPATASRTKPATAAETASSDDASGSGSSSVVEPIPGFKTVQPVVFAGFYPDEGVYITQLREAVDLLCVNDPSVTVEQLQCPALGPGLQLGFLGFLHMQVFKERLLMEFGQAVLVTPPQVQYMYVEQHGDPDDPAQRKPVSVSNWRWPHEGVGAYLEPFVTATVLTPSEYLNEINSAALSAFRGEMQEMRVIDGARTLVRYRMPLADLARGFFSTVKSSSHGYATLEYDDLTYMTADLVKMDIVINKAHISALSTICLRHEANTHARRIIGSLKEKLLRSSVDLPLQALVGSKIIARETVKAYRKDVTAKIHAGDISRKQKKWNDQKKGKERMARRSVGTVTLDQSVLAAALGATTAR", "function": "Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.", "AFDB_id": "AF-A4I9M7-F1-model_v4" }, { "swissprot_id": "P76187", "sequence": "MVQRITIAPQGPEFSRFVMGYWRLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHLRERMEIVSKCGIATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLIHRPDPLMDADEVADAFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRVRPMAWSCLGGGRLFNDDYFQPLRDELAVVAEELNAGSIEQVVYAWVLRLPSQPLPIIGSGKIERVRAAVEAETLKMTRQQWFRIRKAALGYDVP", "function": "May function as oxidoreductase.", "AFDB_id": "AF-P76187-F1-model_v4" }, { "swissprot_id": "Q56902", "sequence": "MSLVINDLLKSLHHLPLIFHMAYSDTKARYKRSMLGPLWLTLGAAVGVVGLGLVWSQLLHQERSELIPSLTIGLLLWQFISGCVIESTSTFVKQSQIIRNLQLPFFIHPIQLIVRQSITLAHNLIVLVVVLIIYPQNLGLVSILSIVGFAIVLINLLWISVMLSIIGARFRDVEQIVQALMPIIFFLTPVLYKAGHAGVNQAIIWLNPFTYFITLVRDPIFGNIPAVFVYQITIGMAIVGWGLTLIIFNRFAPRIAFWI", "function": "May form an ATP-driven O-antigen export apparatus, in association with RfbE.", "AFDB_id": "AF-Q56902-F1-model_v4" }, { "swissprot_id": "P83534", "sequence": "MKKIIVVGSTNVDKVLNVEKYALPGETLAINTYQQSHGGGKGANQAIAAARSGADTTFITKLGNDEDAKMMVKGFKADGMNIDDVITTTDQETGKAYITVDKSGQNSIYVYGGANMAMTPTDVDAHKSAIINADRVIAQLEIPVPAVIEAFKIAKEHGVQTILNPAPAKELPEELLKLTDIITPNESEAATLTGIEVKDETSMLANAKFFFERGIKMVIITVGGRGSFFATPDDHALIPPFPAKVVDTTAAGDTFIGSLASQLEIDLSNIRKAMLYASHASSLTIQVAGAQNSIPTREAILNVINQDQMTKTEIEKQKAQAAAYAAKLVPDHIVLGLGSGTTAAYFVKAINQRINDEHLDIQCVATSVGTEKLAEKLGMRMLDVNTIDQVDLTVDGADVVDHQLNGIKGGGAALLFEKLVADMSKQNIWIVDQSKYTDSLAGHILTIEVIPFGGMGVFRYLKENGYQPEFRFKDNGDILETDSGNYLINIIIPKDADLEKLSIDLKKQTGVVEHGLFLNVCDELIIGGDQIKTIKRSDLS", "function": "Bifunctional enzyme that catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium, and the reversible conversion of ribose 5-phosphate to ribulose 5-phosphate.", "AFDB_id": "AF-P83534-F1-model_v4" }, { "swissprot_id": "Q08218", "sequence": "MSTRPQPDWYYHRHPYASTPLAEGEEPQLLPIQDQGNHKKSKIWMAYKAPIVRWYKNAMLVKDNFWKDLESSHQIIWYPYKGISESVGNSDYLHLFFLIFGYYLLNLLLIVAFTSILAWSLLVCIYLPFLGLFALPLAYMQTILISTTLCNSMVKGTDFVLFTRIYGVTFARKGLTELSEACETISFTPFVYRRSHRLGGLFSKRFYLVSLPQFFIFFFWYIFIAFMFLLLLLVPIVGPITINMLPFSPGMGFYYFEPYFVDVLHLDSRKLSKVYYKGFAKWLLYSISSGLLESIPILGGLFIGTNAVGASLWIVKEIKDRDQPAVPPSPPAEPEEPTVGSYAPPIQQSIAHINPP", "function": "Involved in spore wall assembly.", "AFDB_id": "AF-Q08218-F1-model_v4" }, { "swissprot_id": "Q55370", "sequence": "MFTHLDENQQPRMVDISQKVAGDRRAVAQCIVQLPKAIKDYLTGQEIFLKKGPVIQTAIIAGTMAVKKTADLIPFCHTLPIHGCKFDINIVYQKRDYLEIFLQCAVNTNYKTGVEMEALCGVSVAALTIYDMCKSISSEIIIKNTKLIEKTGGKADVSQTPLYGLVLTGGKSRRMGKDKALINYQGQPHGQYIYDLLAKYCEQVFLSARPSQWQGTPLENLPTLVDRGESVGPMSGILTALQSYPGVNWLIIACDLAYINSTMVEKLIAQARQDLVATCYENADQGFPEALCGFYTPLALQLFTKAQNIGLHCPVKILQMADCQLIKPDNLFDIANINSPEDYGQIN", "function": "Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.", "AFDB_id": "AF-Q55370-F1-model_v4" }, { "swissprot_id": "O30827", "sequence": "MCAESAKICARSRRHSIDDLLSEIHTRAQQYYFSEQIAELAYQALIKEARLTPKPGLVDSTNNGSHQDMSLSTFEQSAIALRPFFTQFVLMGIETTNLPDSHILSKIRPLGLQAEQAMFVATNQVNTHKGAIFAFGLVCTALGRHFSRWQNKMMSSPSFEISQDTTGISLISETVARFTQGITDELKNYSKNQPLTAGITLYQQYGFTGARGEAEKGFPLVQQAVVFILSQAESEMRWYWALLYLMANNNDTNIVHRGGINGLQFIQDEAHKRLGNAKNLQNANALMASLREFDDDCIARNLSPGGSADLLALTIFFLSLLYC", "function": "Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.", "AFDB_id": "AF-O30827-F1-model_v4" }, { "swissprot_id": "Q5AP90", "sequence": "MSINFLSIPRNRFKAIGVLSVTCILIYVILHSSIITTDFDVSDYGDKFIPSIIFDDNNDNGENLKDPQPELDNDKGNGETDTTTSNSMTTAHTFWKGIFDTFDKYKMDLGQDPENAVSYVDKLKQKQGPLNKEVLLSKAIVSSELMKHLKEKHSGVVEDLPSVMPGSVYNKGSKGVVIIGGGKFSWLAYLALVQLRNVGSKLPVEIVMPSRADYEKELEFCENTLPEMQASCVVLPDVLGEAVMKNRKFASYQFKALALVVTSFEHILLLDSDNMIVSNPDEIFESKLYHQYGMITWPDYWKRTISPLFYDVAEIEVNENKRVRYNRFPLYNAPNVRSNIYTDQEREEVPFHDLQGSIAELSTESGQLIINKHTHGKTILLALYYNFYGPNLFYKLFSLGEQGEGDKDTFVAAAVVTRQDYYQVKSFIKTFGYADSDDKFQGVSMGQRNPLIDRKHYEDHVLALLEKDSFKSSSIADQIEQMKKFENEDFDQHNSIPLFTVHCNYPKLDPKLYMSRDDLYDEKEKKLKYRLYGNLKYTKEVVKDGETGTEASTDKVQIDFELQQWQHMQDILCLKKIYFTHFIDNDMNELCQFIENQVAWLSKSQN", "function": "Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.", "AFDB_id": "AF-Q5AP90-F1-model_v4" }, { "swissprot_id": "A8WHT1", "sequence": "MIILKRLFSNMSILQPPEVVRGMTKLEKEAFRMPVDFPVIEIEARDAGIVGRRVRLEPYLIGHKLKPLKNLVDSEKDGKKYLVFHPDKVQEDETRFKILELLKRELGNEKLLDWTTLSKDLTFENWDAKSIFKAVLPVGIDYSSYTQTGHIIHCNFADEILPFRFIIAEVLLDKVNNCKTVVQKGNIITNVYRNLDLELLAGEDNYVTEVKETGLRFKMDFSKVYWNSRLSHEHERVSGMFNTQSLVYDACCGIGPFVLPATLKRKPKRVVANDLNPESVKWLKVNVGLNKIKEERIEIHNMDAKMFIKENVADDVVRLMLEESTAGEFENEVPKPMSEVHVVMNLPAYAVNFLPAFRGALSRFKDEIEKVPLDKRYKWNVYCYLFAKSHVDVPDSWYEDEARRMCDEKTKWERSLVVKCHNVRTVSSRKEMFCAQLELPYEFLLAEPFPDEPEAQCESEEAEEPSSKRIKVDT", "function": "Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.", "AFDB_id": "AF-A8WHT1-F1-model_v4" }, { "swissprot_id": "Q54AX5", "sequence": "MGGNLSSELKSTKYRKREIVDLRKMNIDKLPPTIGALQCKELLLSENDLITIPEEIGKLSKVEIIDFAKNRINYIPPEIGSLATLKQLFLSNNKLFYTPITPNIGALKNLTRLDLSSNQLDDLPVEISNCEALEYLDISDNQLQSFPLEFGKLYNLQVFNCSKNSLKSLPSEISGWVKLEELNVSNNQLAFLPNQICLLGLLSTLNVGFNKLQQLPEELSSMVSLTNLDLKVNPPLQYVPQLSNLRQLKILSIRNLQITHLPLGLGLLSELIELDIRDNPQLKEIPYDIATLINLQKLDLFGNNMRIVPREVGNLINLQTLDLRQNKLTIDNIPSEIGKLVNLKKLLLSNNLLIALPPEIASMKALKEFEASNNQLQAIPTEIGELSGLTKINLSGNKLTSIPASFGNLSELQICDLKSNEIAELPTTLDGLKSCTKIDLSHNMLTELPWEFGDLIGLTILDVGHNPLTIPPNPIVMKGTESIIQWLKKNEKEGRKGKVSGLGIQQDNEK", "function": "Involved in cytoskeleton remodeling, which is needed for normal chemotactic aggregation and efficient cell sorting during multicellular morphogenesis.", "AFDB_id": "AF-Q54AX5-F1-model_v4" }, { "swissprot_id": "Q9P7R5", "sequence": "MLHEIILLLAGNTSGLFIEKNGQILLHPSVQPLHPGERELINDIVSLASKRKRIERYIEIFDEDLIQQNQFLLKALRLLLSKKLFLYDESLANLERMIISSDPYFVGSGKFVSLAQLEAHLADWKETLSSLLVLQGNISQCLSVASTFQKLHNMYMGSTHLNFKKLVLECECAFQKTWLDELVQYLVNDSGDDSFKCSFLCGDTKDFVSCSNNVPFLTQDIVNCLVSIRTCMLNAKKCFTDAFCEILRCFYRLVYEMPLPLTKSSVTKLADEMFTLVSEKIIFQLASFHQIFDLVKMLEMVMLLENVEFLPTLSEMFRDVRGEYCSSNDVQGVVIDDILPVVLRKTISLLDLATEYGECVSFLKLVSIFDEEDEMIRSENRKIDVEGLNMQLLLCLKWPFNLFMDKNALNVYSDLWILLGSLHLSITKIKSLFYERKEYTAKGISQPWTQLWVTLWFLSSLQYYAYECVIKPSYCKLRESLTELYRTQKLRMQDCSQLHALTLTYAKKMLFFYDDDLHISLNSIYHELSLFRSQEVSKVDCQLAAHVSHSIECIRQKENDPSYDREIINALIVQLNL", "function": "Required for proper anchoring of astral microtubules at the spindle pole bodies (SPBs), during anaphase, ensuring correct cell polarity.", "AFDB_id": "AF-Q9P7R5-F1-model_v4" }, { "swissprot_id": "Q06504", "sequence": "MTTIQPFEPVDLFKTNNVNLDILTENFPLEFYFEYMIIWPDLFFKSSEMTVDPTFKHNISGYMMAKTEGKTTEWHTHITAVTVAPRFRRISLASKLCNTLETMTDVMPHEVNFIDLFVKCNNQLAIKLYEKLGYSVYRRVVGYYNSAEDGYPDTLKKVDDNKDAFDMRKAMARDRNRSVRPDGRSHKCYPHDVRF", "function": "Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn, Met-Gln or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions, it is presumed to N-acetylate 15% of all yeast proteins.", "AFDB_id": "AF-Q06504-F1-model_v4" }, { "swissprot_id": "A1ZAX0", "sequence": "MIANLVSMETDLAMNIGLDTSGEAPTALPPMPNVTETLWDLAMVVSQSTQWPLLDTGSSENFSELVTTETPYVPYGRRPETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVICYPYPEEWGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHFNRYLFCRGASGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSCYQSTIRSCRLQETTITTLPNGGNQNGANISAVELALPVLQAPGHNEAHAPPSYGFLPLNEIVQQTRSSPAKFQESLLN", "function": "Receptor for the neuropeptide CCHamide-1. Plays a role in the modulation of starvation-induced olfactory behavior where starved flies show increased responsiveness to food odorants, repellants and pheromones.", "AFDB_id": "AF-A1ZAX0-F1-model_v4" }, { "swissprot_id": "P37062", "sequence": "MKVIVLGSSHGGYEAVEELLNLHPDAEIQWYEKGDFISFLSCGMQLYLEGKVKDVNSVRYMTGEKMESRGVNVFSNTEITAIQPKEHQVTVKDLVSGEERVENYDKLIISPGAVPFELDIPGKDLDNIYLMRGRQWAIKLKQKTVDPEVNNVVVIGSGYIGIEAAEAFAKAGKKVTVIDILDRPLGVYLDKEFTDVLTEEMEANNITIATGETVERYEGDGRVQKIVTDKNAYDADLVVVAVGVRPNTAWLKGTLELHPNGLIKTDEYMRTSEPDVFAVGDATLIKYNPADTEVNIALATNARKQGRFAVKNLEEPVKPFPGVQGSSGLAVFDYKFASTGINEVMAQKLGKETKAVTVVEDYLMDFNPDKQKAWFKLVYDPETTQILGAQLMSKADLTANINAISLAIQAKMTIEDLAYADFFFQPAFDKPWNIINTAALEAVKQER", "function": "Peroxidase whose active site is a redox-active cysteine-sulfenic acid.", "AFDB_id": "AF-P37062-F1-model_v4" }, { "swissprot_id": "Q27601", "sequence": "MSAPQQQQQSQQKQQQHVRVVEQQQVEPAEAVTSSMESESISASKELTGLTHECGVFGAIACGDWPTQMDIAHVICLGLVALQHRGQESAGIATSEGKCSKNFNVHKGMGMISTLFNDDSMKKLRGNLGIGHTRYSTAGGSGVVNCQPFEVHTTHGALALAHNGELVNNESLRREVLARGVGLSTHSDSELIAQSLCCAPEDVSELDGPNWPARIRHFMMLAPLSYSLVIMLKDKIYAVRDTYGNRPLCIGKIVPINAGHGNNLDTPADGWVVSSESCGFLSIGARYVREVEPGEIVELSRSGYRTVDIVERPDFKRMAFCIFEYVYFARGDSIFEGQMVYTVRLQCGRQLWREAPVEADIVSSVPESGTAAAHGYARESGIEFAEVLCRNRYVGRTFIQPSTRLRQLGVAKKFGALSENVAGKRLVLIDDSIVRGNTIGPIIKLLRDAGAREVHIRIASPPLQYPCYMGINIPTREELIANKLNPDQLARHVGADSLAYLSVEGLVEAVQLKHRDAGDSKSKGTGHCTACLTGEYPGGLPDELSW", "function": "Involved in the first step (and regulatory point) of the de novo biosynthesis of purine nucleotides, where it catalyzes the transfer of glutamine amide to 5-phospho-alpha-D-ribose 1-diphosphate.", "AFDB_id": "AF-Q27601-F1-model_v4" }, { "swissprot_id": "Q49GP5", "sequence": "MMAECDPTDGEPGNGSGDSTPETNFLSSEVPAVLFEKTRSAPSLGLSLNPGAAVRISDSTESVLTELEADGSGEEALLLPGPAGSLSPRAGKEKRTRRNMLSSSSDNLASPGNSSGEFNHFPEDPEFGEIIQRAEQAIENGVFPERISQGSSGSYFVKDPKGKIIGVFKPKSEEPYGHLNPKWTKYFHKVCCPCCFGRGCLIPNQGYLSEAAASLVDQKLGLWIVPKTKVVHLASETFHYNAIDRAKSRGKKYALEKVPKVGRRFHRVGLPPKVGSFQLFVEGYHEADFWLRKFEAEPLPENMRKQLQSQFERLVVLDYVIRNTDRGNDNWLIKYEKPGDGELTEKESEWTDPKDSAIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVAFSQETRDLVLSRISDMNFVQDLCEDLYEMFRTDKGFDKTMFEKQMSVMRGQILNLTQALKDGKSPIQLVQMPRVVVERSRSGGQGRVVQLGNAFTQTFHCKRPFFTSW", "function": "Contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).", "AFDB_id": "AF-Q49GP5-F1-model_v4" }, { "swissprot_id": "Q12739", "sequence": "MFPGARILATLTLALHLLHGAHAAIGPAGNMYIVNEDVSPDGFARSAVVARSVPATDPTPATASIPGVLVQGNKGDNFQLNVVNQLSDTTMLKTTSIHWHGFFQAGSSWADGPAFVTQCPVASGDSFLYNFNVPDQAGTFWYHSHLSTQYCDGLRGPFVVYDPSDPHLSLYDIDNADTVITLEDWYHIVAPQNAAIPTPDSTLINGKGRYAGGPTSPLAIINVESNKRYRFRLVSMSCDPNFTFSIDGHSLLVIEADAVNIVPITVDSIQIFAGQRYSFVLTANQAVDNYWIRANPNLGSTGFVGGINSAILRYAGATEDDPTTTSSTSTPLLETNLVPLENPGAPGPPVPGGADININLAMAFDFTTFELTINGVPFLPPTAPVLLQILSGASTAASLLPSGSIYELEANKVVEISMPALAVGGPHPFHLHGHTFDVIRSAGSTTYNFDTPARRDVVNTGTGANDNVTIRFVTDNPGPWFLHCHIDWHLEIGLAVVFAEDVTSISAPPAAWDDLCPIYNALSDNDKGGIVPS", "function": "Lignin degradation and detoxification of lignin-derived products.", "AFDB_id": "AF-Q12739-F1-model_v4" }, { "swissprot_id": "P54576", "sequence": "MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTTQNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDDYVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDMIVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQGKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNRANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGILTRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGASEQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEANMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAVVADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVLNTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDEQLVTLDKVKHSTETLKHASQELMNTIAKFTL", "function": "Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. All amino acids serve as attractants in B.subtilis, they appear to cause an increase in the turnover methyl groups, leading to methylation of an unidentified acceptor, while repellents have been shown to cause a decrease in methyl group turnover. The methyl groups are added by a methyltransferase and removed by a methylesterase. McpC is required for taxis to cysteine, proline, threonine, glycine, serine, lysine, valine and arginine and for aspartate, glutamine, histidine and glutamate. Primarily mediates response to positive stimulus of PTS carbohydrates. Greatly influences the duration or magnitude of the response to negative PTS carbohydrate stimulus.", "AFDB_id": "AF-P54576-F1-model_v4" }, { "swissprot_id": "G4MWA8", "sequence": "MKLRVSQSPTPQMVITMLHGSSTYSLLASKKRNSNVVGQYIKNGIPFRMRNPADPSQPQVILPFKYLSEMKNAAESSWSFMHFSNQSFLLEYINAPLGSSIAHQVVRGELNKNLDWTALQPYMLFANTIARTTSLVLAGPELSANPEWTTIMVTFTMTLMQTSQEVRAKYSPWLRWLVPWIHPGAKNLYKIRKRCAQLLAPSYQNRRAGMVGDEKPFMDAIQWLMNKRTYKSKDLMKLSDDQLFLSVASIHSTSASTLSTLYDLLDRPECMDGILHEIRTIRAESKSSDWTKHDLDRLVKLDSFMKESQRYHPVGQVTVQRSNPRAYEFSDGLKIPANTQTCFLSYELNHDPDVYPDPETFDADRFLRMREKVDPQKYHFAYVSEDSINFGAGAHSCPGRHFAANEIKLMLCELLLGYEMKWPDGQSRPPTMFHDFSSNPNPGFDICIRERRL", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of a tyrosine-derived cytochalasan acting as a fungal signal recognized by resistant rice plants and leads to avirulence in Pi33 resistant rice cultivars. The first step in the pathway is catalyzed by the hybrid PKS-NRPS ACE1, assisted by the enoyl reductase RAP1, that are responsible for fusion of the tyrosine precursor and the polyketide backbone. The polyketide synthase module (PKS) of ACE1 is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the tyrosine precursor. Because ACE1 lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase RAP1. Reduction by the hydrolyase ORFZ, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ORF3 then yield the required isoindolone-fused macrocycle (Probable). A number of oxidative steps catalyzed by the tailoring enymes identified within the cluster, including cytochrome P450 monooxygenases CYP1 to CYP4, the FAD-linked oxidoreductase OXR2 and the short-chain dehydrogenase/reductase OXR1, are further required to afford the final cytochalasans that confer avirulence and which have still to be identified (Probable). The monooxygenase CYP1 has been shown to be a site-selective C-18 hydroxylase whereas the function of CYP3 is the site-selective epoxidation of the C-6/C-7 olefin that is present in some intermediate compounds. Finally, SYN2 and RAP2 are not required for avirulence in Pi33 resistant rice cultivars.", "AFDB_id": "AF-G4MWA8-F1-model_v4" }, { "swissprot_id": "I1RV24", "sequence": "MPPQQEQDTDSDAIRSYNEESKSETPGCIPDAMLSSDETSNDVASDISPPPDGGWNAWLCTLCGHFLFMNTWGFINSFGIFQTYYTTFLDRDPSDISWIGSIQVFLSFFVGAFVGRYIDSGHLRLVLSCGTILVLIGIFTASLSTQYWQLILSQGICCGLGNGFLVTPAVSVTSTYFAKRRSLAIGISTCGSVTGALVFNSMARQLLPTAGFGWTMRAIGFVQAATLLFVVVAMKTRLPPTKSGRLVEWVAFKQLDYTFFTIGMFFNFWAVFFGYYYIAPYSRDIITPTLTYTQSLNLLLILNGVGVFGRMIANHYADTFGPLELLIPTCLVAAVATFSWIAVDTPTHAYVWTVFYGIIGGSILSLFPAGISCLTTDLSTRGAYIGMNFTVISFATLTGNPIAGAIITAMQGRYYGAQAFMGSSFIVGTAFIVAAKMNHVK", "function": "MFS-type transporter; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat.", "AFDB_id": "AF-I1RV24-F1-model_v4" }, { "swissprot_id": "Q8H1F6", "sequence": "MFAQLAPSPSPSPANVSHFVHRRTFRQCTYAVSASLPTANSSRPPPIQIVGGKDLNLDVTRKDDSIGFKLEANEDEIDWMNLESDIRLWTRALRPVQWYPGHIMKTEKELREQLKLMDVVIEVRDARIPLSTTHPKMDAWLGNRKRILVLNREDMISNDDRNDWARYFAKQGIKVIFTNGKLGMGAMKLGRLAKSLAGDVNGKRREKGLLPRSVRAGIIGYPNVGKSSLINRLLKRKICAAAPRPGVTREMKWVKLGKDLDLLDSPGMLPMRIDDQAAAIKLAICDDIGEKAYDFTDVAGILVQMLARIPEVGAKALYNRYKIQLEGNCGKKFVKTLGLNLFGGDSHQAAFRILTDFRKGKFGYVSLERPPL", "function": "GTPase that may function in chloroplast ribosome assembly (Probable).", "AFDB_id": "AF-Q8H1F6-F1-model_v4" }, { "swissprot_id": "Q6P7K0", "sequence": "MANEACPCPCDIGDKIEYGAKGQEVQIEHIKAYVSKPHSSTDKAVIVVQDIFGWQLPNTRFMADLLTAHGYITICPDFFVGQEPWKPSNDRSTFTEWLQTRQATKVEKEINVVLKYLKEQCHVKKIGVIGFCWGGVVTHHLMLKYPELKAGVSFYGIIRDVEDRYNLLNPTLFIFAEMDHVIPLEQVSLLEEKLKVHSKVDFQVKVFPKQTHGFVHRKNEDINPEDKPFIEEARKNMLEWLHKYIN", "function": "Cysteine hydrolase.", "AFDB_id": "AF-Q6P7K0-F1-model_v4" }, { "swissprot_id": "Q8RF14", "sequence": "MKDKNCLFDLINKIESIDNVSIKKAQTELDRKMKPKDSLGVLEDICKKTAGIYGYPLKKLEKKCHIVVAADNGIIEEGVSSCPIEYTSIVSEAMLNQIACIGIFTKTLGIDLNVVDIGMKNDIKRNYPNLIHKKIRRGTNNFYKERAMSINECLEAIFTGIDIINEKSKDYDMFSNGEMGIANTTTSSALLYSVTRQNIDDIVGRGGGLSDEGLNKKKKVIIEACERYNTFEMDAVEMLASVGGFDLACMLGIYVGAALNKKLILVDGFISSVAALLACSLNKNIQDYLLFTHKSEEPGVNIILDYLKEKTFLNMNMRLGEGTGAVLACPIIDCAIEMINTMKSPEEVYNLFNK", "function": "Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).", "AFDB_id": "AF-Q8RF14-F1-model_v4" }, { "swissprot_id": "P54070", "sequence": "MHVLLSKKIARFLLISFVFVLALMVTINHPKTKQMSEQYVTPYLPKSLQPIAKISAEEQRRIQSEQEEAELKQSLEGEAIRNATVNAIKEKIKSYGGNETTLGFMVPSYINHRGSPPKACFVSLITERDSMTQILQSIDEVQVKFNKNFAYPWVFISQGELDGMKQEMIRQAITDSMNGDPELINIKFAEIPADEWVYPEWIDENKAAESLISLANVPDGDSRAVRYQARYFAGFFWRHPVLDEFDWYWRVDPGIKLYCDIDHDLFRWMQDEGKVFGFTLSMSEAKEANEKIWDVTKKFAKDFPKFISENNFKSFITKKDSEDFNNCEFTSNFEIGNLNFYRSPAYRKFFNYIDEEGGIFYWKWSDSIIHTIGLSMLLPKDKIHFFENIGFHYDKYNNCPLNDDIWNQYNCNCDQGNDFTFRSGSCGGHYFDIMKKDKPEGWDRLP", "function": "Glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Required for addition of mannosylphosphate in yeast mannan. Recognizes any oligosaccharides with at least one alpha-1,2-linked mannobiose unit.", "AFDB_id": "AF-P54070-F1-model_v4" }, { "swissprot_id": "Q90VZ3", "sequence": "MSYGQIRLVETSGASGATSQQDNLGYSGVKASHKMAEIDSGRMSKYKSKINKVGQSYGIEPALIAAIISRESRAGNQLKDGWGDWNPQRQAYNAWGLMQVDVNPNGGGHTAVGGWDSEDHLRQATGILVTFIERIRTKFPGWSKEKQLKGGIAAYNMGDKNVHSYEGVDENTTGRDYSNDVTARAQWYRDNGYSG", "function": "Possesses lytic activity against M.lysodeikticus and several fish pathogenic bacteria.", "AFDB_id": "AF-Q90VZ3-F1-model_v4" }, { "swissprot_id": "P0CF91", "sequence": "MNYSHDNWSAILAHIGKPEELDTSARNAGALTRRREIRDAATLLRLGLAYGPGGMSLREVTAWAQLHDVATLSDVALLKRLRNAADWFGILAAQTLAVRAAVTGCTSGKRLRLVDGTAISAPGGGSAEWRLHMGYDPHTCQFTDFELTDSRDAERLDRFAQTADEIRIADRGFGSRPECIRSLAFGEADYIVRVHWRGLRWLTAEGMRFDMMGFLRGLDCGKNGETTVMIGNSGNKKAGAPFPARLIAVSLPPEKALISKTRLLSENRRKGRVVQAETLEAAGHVLLLTSLPEDEYSAEQVADCYRLRWQIELAFKRLKSLLHLDALRAKEPELAKAWIFANLLAAFLIDDIIQPSLDFPPRSAGSEKKN", "function": "Involved in the transposition of the insertion sequence IS186.", "AFDB_id": "AF-P0CF91-F1-model_v4" }, { "swissprot_id": "Q8NH08", "sequence": "MDSPSNATVPCGFLLQGFSEFPHLRPVLFLLLLGVHLATLGGNLLILVAVASMPSRQPMLLFLCQLSAIELCYTLVVVPRSLVDLSTPGHRRGSPISFLSCAFQMQMFVALGGAECFLLAAMAYDRYVAICHPLRYAAVVTPGLCARLALACCLRGLAVSVGLTVAIFHLPFCGSRLLLHFFCDITALLHLACTRSYADELPLLGACLVLLLLPSVLILASYGAIAAALRRLRCPKGRGKAASTCALHLAVTFLHYGCATFMYVRPRASYSPRLDRTLALVYTNVTPLLCPLIYSLRNREITAALSRVLGRRRPGQAPGGDLREL", "function": "Odorant receptor.", "AFDB_id": "AF-Q8NH08-F1-model_v4" }, { "swissprot_id": "Q2FQR4", "sequence": "MDWAEKYRPRHLNEMVGNREALHQMSEWATRWTVESPPLILYGKPGIGKTSSAWALAHDMNWEVVELNASDQRTKAVIEKVAGGSASTGSLTGAARKLIILDEADNLQGNADRGGARAIAEVIRQARQPLILIANDLYGLDGTIRNLCTKVQFKALPAKSLVPRLREICSREQLTCSAQALTDIAEQSGGDIRSAVTMLYASAIGKDTVGEDDVSISAKDSRASIFDLVAATLGYRQVPSLLDMSMSVDETPDTILQWIEGNLGVLPDRKKTAQAYAALSRADMYLGYTFLTQYYTLWRYATSVMLYGVHDVMKGRPSGYAKIMPPSRWRQMSVAKKQKTIREQLLSDMGTSMHMSASTVRNLYLCPISLLAKQFPEQFAKSYDLDVDKLDILIHDPATSKSIIKKIEDEKKQIEKELKKKKKEEDAKGKKARGSKKEKEPIVEETPSIDSFSSQEPGNPPEQPSTEPVEKDKKSSQSTLFSF", "function": "Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.", "AFDB_id": "AF-Q2FQR4-F1-model_v4" }, { "swissprot_id": "P70985", "sequence": "MNTQKPFENHLKSVDDLKTTYEEYRAGFIAFALEKNKRSTPYIERARALKVAASVAKTPKDLLYLEDIQDALLYASGISDKAKKFLTEDDKKESINNLIENFLEPAGEEFIDELIFRYLLFQGDSLGGTMRNIAGALAQQKLTRAIISALDIANIPYKWLDSRDKKYTNWMDKPEDDYELETFAKGISWTINGKHRTLMYNITVPLVKKNVDICLFNCEPEIYTPQKVHQQPEKYLLLGELKGGIDPAGADEHWKTANTALTRIRNKFSEKGLSPKTIFIGAAIEHSMAEEIWDQLQSGSLTNSANLTKTEQVGSLCRWIINI", "function": "A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-CYCGRG-3' and cleaves after C-1.", "AFDB_id": "AF-P70985-F1-model_v4" }, { "swissprot_id": "B0ZT45", "sequence": "MVFCTYCGHSFTRDEHLERHILTHTNVKPFKCFTCHMSFARRDLLQGHYTVHGRNQDQQEIPAANGMIPKSAGRTPIACSNCAKTKTKCDKKFPCSRCASRNLRCTLRPTLVSTKNAARMGLITPETIAQDIANGTLPPDQTVAAEKVPLPIAPTGHVEESSKSSSPSGSPTSISHNSTGSDAPPAPMFDQFNGCPTPPQGLSPTTPSGQGFNGPASFPGFDDYNQQIGKTSAEDCNLHFMLDWQQLQLPIGLDPMLQPDMLGDQDLNFDMGAMGLGTQMEPILSINPELTNNMPPPLITPIETPKFDRSSSDLDAFSSGLHDRQYSVVSNQSVDSHYQAPPQPDPVVVAQDGWNVFRCVPSVHPSACPSTARWNLEALESTLQNHDGRSKWRPEVDENLFDGSDQLAVMQIHESTRDKLLAITQGFLHKALEIHRGNEAAQTYAPSNFVLLPPTKVLEYFLRSYTNSFERFYPLTSKGSLDANELMFCYQDRASSLLILLMVAQGAMNVPSREARSLTGGLVETCRISLFDLIERNIVMASDHNVLHAALIFTELASWSGDKWQMDIAMGQRGMYAAMLRHSGVLDRTTYPPQGSFSDGQTNADHMWNLWIQQESRSRPVYSWAMVDQELALFHGASPLFSVTEFGIALPHNEELWRAKSAGEWTSLMGQRVSTTDSDATASPPSLRDLSRRFLDDEMDSAECFLNPMHLRLLLLPLQAMVGHYQQLMCCFSDSGSSRVKNKTVTASSTRCRLEEVQCLLQRWYNIAMDYLKEHSVCSVMQASLVLYHLISLNAVTDFVQIERLARRETFDGTYQSLVWTHKRCITDVGEAIFHCGQVISLIRSMPRSVRPPWWAASIYRVALVLWCDSLIDKDGSSSYGGKSGQTFAVDALPSDHPLIQRYLNKGEGTPRLSKRDGSTIGLDHGLTVLNHCAEIIDEGATSRFQEGIRGKLDRLMRT", "function": "Elsinochromes biosynthesis cluster-specific transcription factor that positively regulates the expression of cluster genes including RDT1, PKS1, PRF1 and HP1, and subsequent elsinochromes production.", "AFDB_id": "AF-B0ZT45-F1-model_v4" }, { "swissprot_id": "O83506", "sequence": "MMELSRTPAVMRLLEYAREKKAITHDEVENILAHYGVETEELLHDVLDMLEQENIKVFSSEEEELEDEVFAGLKGPAADDGDGSFPLSTERVRDKLCDSSRGARQNLLSNARNIALDDPVKLYLRDIGQEKLLTAEQEVMLSKRMEEGEGIIKDIITQSGLLLPEFYHIGRSLSKKALAVLDPAESGRTRKEISEEMADRRRLKQAYGEVLRSLYPEMRHYMAMKKRLDERGEPVTVLSSDEEVCKQRDKLLSCLQKVDLQLEEIDRFSRKFLDTARKIREYKRRKDRHEKQLMIADLCDMRKIGRGLAVPRQRAKLEETLGMSADCIQEIYTQIQKVTRRLRRIEYDFENTIDGILSMARAIHRGHVMLKKAKDKLINANLRLVVSIAKKYTNRGLLFFDLVQEGNIGLIKAVEKFEYRKGYKFSTYATWWIRQAITRSISDQARTIRVPVHMIEQINKVTRESRQLLQKFGREPSDEEIAQQLCWTVEKVKQVKSVAREPISLETPIGEEEDSSLGDFVPDADVENPSRVTERVLLKEEVRSILSALPAREHEVLRMRFGLDGDYSQTLEEVGLYFDVTRERIRQIEAKALKRLRHPRHSRRLKDFLDS", "function": "Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.", "AFDB_id": "AF-O83506-F1-model_v4" }, { "swissprot_id": "G5CTG7", "sequence": "MADAPTYIRQSTTGTATTAPTTMPVHPDTTYYKTTTTTVSDAPRAIADVNDDNHDNYDETTGLRSGEKKTRPLVTSTTAPIDAGRMTLGQKISRWTRIGSDLAREALAEFLGSFILIVFGNGVVAQVVLSRGAHGNFLSINIGYGLAVAFGVYIAGGISGGHLNPAVSLAFAALGKLPWRKLPVYMFAQYAGCICASAIVHAIYYDALNNYDGGNRTRGDTWQSTAGIHASYPQEFLYWQTGLADQIFATSFLMIGILALTDNRNTGPPGGVVPILVGCLVMAIGLAYGFNCGYPINPARDMGPRLFTLMAGWGSRTFSNYNPYIFNDYYQRIPYWFWIPVVGPHLGALLGAAIYFFFIGNHWPTLHRNVLELQVGHRDNSDDIELLAAKSRRPIEVVTTTETTRERRT", "function": "Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.", "AFDB_id": "AF-G5CTG7-F1-model_v4" }, { "swissprot_id": "P56066", "sequence": "MKMYNIPTPTMAQVIMVDDPITTTEFVISALRDFFDKSLEEAKALTSSIHRDGEGVCGVYPYDIARHRAAWVRDKAKALEFPLKLLVEEIK", "function": "Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.", "AFDB_id": "AF-P56066-F1-model_v4" }, { "swissprot_id": "Q1G3I2", "sequence": "MCRGFEKEEERRSDNGGCQRLCTESHKAPVSCELCGENATVYCEADAAFLCRKCDRWVHSANFLARRHLRRVICTTCRKLTRRCLVGDNFNVVLPEIRMIARIEEHSSDHKIPFVFL", "function": "Developmental regulator acting by forming heterodimeric complexes, that sequester CO and CO-like (COL) proteins into non-functional complexes. Engages CO and the transcriptional repressor TPL in a tripartite complex. Involved in the CO-mediated long-day flowering-promotion pathway.", "AFDB_id": "AF-Q1G3I2-F1-model_v4" }, { "swissprot_id": "A0A0H2ZJC1", "sequence": "MSEEELEQDELDGADEDDGEELAAADDGEADSSDGDEAPAPGKKAKAAVVEEELPSVEAKQKERDALAKAMEEFLSRGGKVQEIEPNVVADPPKKPDSKYGSRPI", "function": "Causes widespread changes in gene expression, and plays a direct role in the regulation of genes encoding ribosomal components. Associates with chromosomal DNA through interaction with RNA polymerase. Contributes to biofilm formation and secondary metabolite production. Important during transitions to and from the survival state.", "AFDB_id": "AF-A0A0H2ZJC1-F1-model_v4" }, { "swissprot_id": "B7GPC7", "sequence": "MTFIKQMMPRYVASMTAGIVAAAMAATCAFAPVANADAVSPTQETIQSTGRHFMVYYRAWRDVTMKGVNTDLPDDNWISMYDIPYGVDVVNIFSYVPSGQEEQAQPFYDKLKSDYAPYLHSRGIKLVRGIDYTGVAVNGFRTFMKEQNKTESEATEADYDAYAKQVIDKYMISVGLDGLDIDMEAHPNDADVKISDNVIRALSKHIGPKSAKPDTTMFLYDTNGSYLNPFKNVAECFDYVAYQQYGSSSDRTARAAADYQPYIGNEFVPGLTFPEEGDMNNRWYDATEPYEESHFYQVASYVREHNLGGMFVYALDRDGRNYDEDLRRIVPSNLLWTKTAIAESEGMALDTAKTAANHYLDRMSLRQVIDDNAASADKARDMVGKAANLYETNKAVLGGDYGEGFSNTYDPTLEAGLLGIDISVLQQQIDKSSEIIGADTAESDAKTALRMARDAAIDGLTGKIYTADQVSAWSQALKAALDATVPVPTPDSTDQNGNRDKVTNHKVQGQPKQLSATGISTDIIVAVGVTLAIAGVALSLSRKLS", "function": "Endoglycosidase with broad specificity that cleaves the chitobiose core of high mannose and complex N-linked glycans. Is able to release N-glycans from diverse host glycoproteins such as human and bovine lactoferrin, immunoglobulins A and G, and ribonuclease B. Is active directly on human breast milk - a complex matrix of lipids, oligosaccharides, and proteins with disparate glycosylation types - successfully removing a significant proportion of the total amount of N-glycans. Does not recognize O-linked glycans or free human milk oligosaccharides (HMO).", "AFDB_id": "AF-B7GPC7-F1-model_v4" }, { "swissprot_id": "P35196", "sequence": "METDSGIPGHSFVLKWTKNIFSRTLRASNCVPRHVGFIMDGNRRFARKKEMDVKEGHEAGFVSMSRILELCYEAGVDTATVFAFSIENFKRSSREVESLMTLARERIRQITERGELACKYGVRIKIIGDLSLLDKSLLEDVRVAVETTKNNKRATLNICFPYTGREEILHAMKETIVQHKKGAAIDESTLESHLYTAGVPPLDLLIRTSGVSRLSDFLIWQASSKGVRIELLDCLWPEFGPIRMAWILLKFSFHKSFLNKEYRLEEGDYDEETNGDPIDLKEKKLN", "function": "With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).", "AFDB_id": "AF-P35196-F1-model_v4" }, { "swissprot_id": "A0A0H3B0B8", "sequence": "MLSAGSIDVSSQNIAVAGSSVVADKDIRLRAQENLTVSTAQQSESGTQLFEQKKSGLMSTGGIGVFIGTSRQKTTDQTQTVSHIGSTVGSLTGNVRLEAGNQLTLHGSDVVAGKDLALTGADVAISAAENSRSQQYTAESKQSGLTVALSGPVGSAVNTAVTTAKAAREENTGRLAGLQGVKAALSGVQAVQAGQLVQAQGGGITEMVGVSVSLGSQKSSSQQQQEQTQVSGSALTAGNNLSIKATGGGNAANSGDILIAGSQLKAGGDTRLDAARDVQLLGAANRQKTDGSNSSRGGSIGVSVGGSGLSVFANANKGQGNERGDGTFWTETTVDSGGMFSLRSGRDTTLTGAQVSAETVKADVGRNLTLQSQQDRDNYDAKQSRASGGISVPVAGGGAAVNLSMSRDRLSSQYDSVQAQTGIFAGSGGVDIRVGEHTQLDGAVIASTAAADKNTLDTGTLGFSDIKNKAVFTVEHQGGSLSTGGPVGSDLLSNLGGMVLAGLGNGGYAEGTTQAAVSEGTITVRDTENQQQNVDDLSRDTGNANGSIGPIFDKEKEQNRLKEVQLIGEIGGQALDIASTQGKIIATHAANDKMKAVKPEDIVAAEKQWEKAHPGKAATAEDINQQIYQTAYNQAFNESGFGTGGPVQRGMQAAIAAVQGLAGGNMGAALTGASAPYLAGVIKQSTGDNPAANTMAHAVLGAVTAYASGNHALAGAAGAATAELMAPTIISALGWDKNTLTEGQKQAVSALSTLAAGLAGGLTGDSTADALAGGQAGKNAVENNYLNSTQALTFDKELSDCRKSGGNCQAVIDKWKKVSDEQSVKLDETLKNNPLEAQVWDKEVAQGGIAITERPGWLSSLGADVMSSEEAKAYVQQWNGQDLSKIDVNSPGWTKFAAFASDPENQVAVASLGMLGKDLTKAALSYMGRNTSTATVSASSVGMKWGQGNMKQGMPWEDYVGKTLPVGSRLPPNFKTYDYFDRATGAVVSAKSLDTQTMAKLSNPNQVYSSIKKNIDVTAKFEKASLSGVTVNSSMITSKEVRLAVPVNTTKAQWTEINRAIEYGKNQGVKVTVTQVK", "function": "The CdiA protein is thought to be exported from the cell through the central lumen of CdiB, the other half of its two-partner system (TPS). The TPS domain probably remains associated with CdiB while the FHA-1 domain forms an extended filament with the receptor-binding domain (RBD) at its extremity; in the secretion arrested state the C-terminus of the RBD and YP domains form a hairpin-like structure as the FHA-2, PT and CT domains are periplasmic. The YP domain is probably responsible for this arrest at the point where it re-enters the host cell periplasm. Upon binding to a target cell outer membrane receptor a signal is transmitted to activate secretion. The filament elongates slightly, the rest of CdiA is secreted and the FHA-2 domain becomes stably associated with the target cell's outer membrane where it facilitates entry of the toxic CT domain into the target cell periplasm. From there the toxic CT domain is cleaved and gains access to the target cell cytoplasm via an inner membrane protein.", "AFDB_id": "AF-A0A0H3B0B8-F1-model_v4" }, { "swissprot_id": "C6X2D2", "sequence": "MKPFRFKKFTVQQHKEVFRVGTDGVLLGALADVSDAKNILEVGTGTGLVALMTAQRNPTSNITAIDVNPVAAELAAKNFLESHFGHRMRAMHCDYKTFGTQKKFDLIISNPPYFETNPSEKDATARQQRELSFKTLISKTAEILATEGRFCVIIPFPAGPTFEKTCEENKLFLLRRITVYGNANVEPKRLILEFSSNKNISVSEEIFVTEKAPRVYSEQYLKATADFHEFE", "function": "Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).", "AFDB_id": "AF-C6X2D2-F1-model_v4" }, { "swissprot_id": "Q8NEQ6", "sequence": "MAPSEDPRDWRANLKGTIRETGLETSSGGKLAGHQKTVPTAHLTFVIDCTHGKQLSLAATASPPQAPSPNRGLVTPPMKTYIVFCGENWPHLTRVTPMGGGCLAQARATLPLCRGSVASASFPVSPLCPQEVPEAKGKPVKAAPVRSSTWGTVKDSLKALSSCVCGQAD", "function": "May regulate the transcriptional function of androgen and estrogen receptors.", "AFDB_id": "AF-Q8NEQ6-F1-model_v4" }, { "swissprot_id": "Q9FKW9", "sequence": "MEKPGMSLLKGSLCVIVFLLLLSLVESVKGGGYVKYGTEAKVVPGKLNVHLVPHSHDDVGWLKTVDQYYVGSNNRIQNACVRNVLDSVVDSLLRDPNRKFVFAEMAFFTRWWEEQSPERQEQVRRLVKSGQLEFVNGGWAMNDEATCHYIDMIDQTTKGHRFIKQQFNTTPRAAWQIDPFGHSSVQAYLLGAELGLDSVHFARIDYQDREKRKAEKSLEVIWRGSKTLDSSSQIFTNIFFVHYGPPTGFHYEVTDDYVPLQDNPRFDGYNIKEAVNDFVNASLVYANVSRGNHVMWTMGDDFQYQFAESWFRQMDRLIHYVNKDGRVNALYSTPSLYVDAKNVANVTWPLKTHDFFPYADRAYAYWTGYFTSRPALKRYVRALSGYYMAARQLEFLVGKNSGGPNTYSLGDALGIAQHHDAVTGTAKQHVTNDYMKRLALGASEAEAVVNSALACLMNKAPKGGCTKPAIAFSQQCSLMNISYCPSTEETLPGQKSLILVAYNSLGWNRTEIIRIPVNDAGLSVEDSSGNTLDAQYIPMDNVTSNLRSFYTKAYLGISSLQRPKYWLVFKAKVPPLGWNTFFISKASAQGSNNHKHSSVMLSPMNNTTEIGPGNLKMVFSSDSGRLERMYNSRTGADIKVDQNYFWYASNVGDAKDPQVSGAYIFRPNGSLAYPVSSSKICTVTSAFIGNGNVQSKLQIVRGPLIDEVHQQFSPWVAQVVRLYKEKEHAEFEFTIGPISVGKGHLTGKEIITRMVTDMTTAKEFYTDSNGRDFLKRVRDNRTDWHLEVNEPIAGNYYPLNLGMYIKDEKAELSVLVDRATGGASIKDGEIELMLHRRTSMDDSRGVEESLVETVCVNDTCAGLTIRGNYYVSINKVGEGGRWRRETGQEIYSPLLMAFAHENKEKWKASNTVKGYAMDHLYTLPQNIALITLEELDLGNVLLRLAHLYEAGEDSDYSKIAKVELKKLFSGKMIKEVTEMSLSANQEKVKMKEKMKWKVEGEAEQPSSPLRGGPVDKSTLVVELGPMEIRTFVVQFYQKQRRRKLFVG", "function": "Liberates mannose from p-nitrophenyl-alpha-D-mannoside in vitro.", "AFDB_id": "AF-Q9FKW9-F1-model_v4" }, { "swissprot_id": "E9RAH5", "sequence": "MSIGKLLSNGALLVDVLIIGAGPAGLSTATGLARQLHTAVVFDSGVYRNAKTQHMHNVLGWDHRNPAELRAAGRADLTTRYSTIQFQNSTIEAIRQVETNQLFEARDNEGHSWYGRKVVLATGVRDIPLDIEGYSECWANGIYHCLFCDGYEERGQETVGVLALGPIANPARALHLARMALRLSESVTIYTNGNEQLAKEIQQAAEESPVGASGLKFEARPIRRFEKGDVAKTVIVHLGESESKTEGFLVYNPQTEVNGPFAKQLALNMTEGGDILTTPPFYETSVPGVFAVGDCATPLKAVTPAVSMGSLAAGGLVAQLQAQALPEFRLDQEL", "function": "Thioredoxin reductase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp. The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain. The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin. This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties. Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure. GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides. Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA. GliT is required for self-protection against gliotoxin. GliT plays a role in preventing dysregulation of the methyl/methionine cycle to control intracellular S-adenosylmethionine (SAM) depletion and S-adenosylhomocysteine (SAH) homeostasis during gliotoxin biosynthesis and exposure.", "AFDB_id": "AF-E9RAH5-F1-model_v4" }, { "swissprot_id": "Q9M8T8", "sequence": "MAMASASSSSSSISVIIFLLLAPLCLSREPPSQIPNGTLDLSLLWYGQFTPTQKERVHDFIESLNFDAKEGLDPKVSAWWKVVESYQERFEVKDIYRQKKSNRTVAPRIKVKVVRSYVDEKMKYGKELTMGNGEKLVETAIGNMSKVVPVVLLSAQVRAHGVGFCDGTCQHNALAKIKGQKEPRRYIMVSNPEVECPGECAWPFHTADKGPRGMTYQPASGEVGADALVIQLATGLADLATNPDLTKSLFKSETTPYNDDVKKNHESSSMYIVDPATKCTRVFGSGAFPGFTGRIRVDPITGGAFNSHGINHLKFLIPSIWDPKTKSCWTPM", "function": "May play a role in a brassinosteroid-dependent regulation of growth and development.", "AFDB_id": "AF-Q9M8T8-F1-model_v4" }, { "swissprot_id": "Q2TBI2", "sequence": "MVICCAAANCSNRQGKGEKRAVSFHRFPLKDSKRLMQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLAEKKRRAGGHGRPRRRDTGKASAGLRAQASDPVDGKAAAGSPSSSSASPMAKPEPRKLKRATPQGRTAARAARETAGQERGRQPLEGRAEDGPASAATSCSQGEAGTGAEDAGEEGATPADRGLVDRSGVSADDFTPPGSGACKFIGSLHSYSFSSKHARERPAVPREPVERKRLRRDAEPGCSGSSPGPEKGPAQSPPRACPSASSSLTATPQKPAQGASAPPTDVTPKPAAEAVQSEHSDASPMSINEVILSASGACKLIDSLHSYCFSSRQSKSQVCCLREQVEKKNGELRTLRQRVSRSDSQVRELRQKLDQLRRLSLPHLSSLLPPGREPPKMSPVVEPLSWMLGTWLSEPPGAGTFPTLQPFRYLEEAHISHVGQPMLNFSFNAFHPDTHKPMHRECGFIRLEPDTNKVAFVSAQNTGIVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGNLEQTVSMATTTQPLTQHLHVTYKKVTP", "function": "Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region.", "AFDB_id": "AF-Q2TBI2-F1-model_v4" }, { "swissprot_id": "Q8N307", "sequence": "MGCLWGLALPLFFFCWEVGVSGSSAGPSTRRADTAMTTDDTEVPAMTLAPGHAALETQTLSAETSSRASTPAGPIPEAETRGAKRISPARETRSFTKTSPNFMVLIATSVETSAASGSPEGAGMTTVQTITGSDPREAIFDTLCTDDSSEEAKTLTMDILTLAHTSTEAKGLSSESSASSDSPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGLHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSWSPGSDVTLLAEALVTVTNIEVINCSITEIETTTSSIPGASDTDLIPTEGVKASSTSDPPALPDSTEAKPHITEVTASAETLSTAGTTESAAPDATVGTPLPTNSATEREVTAPGATTLSGALVTVSRNPLEETSALSVETPSYVKVSGAAPVSIEAGSAVGKTTSFAGSSASSYSPSEAALKNFTPSETPTMDIATKGPFPTSRDPLPSVPPTTTNSSRGTNSTLAKITTSAKTTMKPPTATPTTARTRPTTDVSAGENGGFLLLRLSVASPEDLTDPRVAERLMQQLHRELHAHAPHFQVSLLRVRRG", "function": "May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.", "AFDB_id": "AF-Q8N307-F1-model_v4" }, { "swissprot_id": "P59014", "sequence": "MEFTHLDENGMVRMADVSGKPPTRRKACASGRIVMLPETIALLRRKELPKGNVLAAAKIAGIQAAKQTSTLIPLCHQLNLSWIDIEFEIGDDSIGIAATVITRESTGVEMEALAAVSVAALTIYDMCKAVDKTMEISAIRLDHKTGGKSSAAEYHPRTAILVMSDSIAAGTATDHSGAILREGLQKAGCAVEALTITPDEPVEIAATVEAWIGEGIEFIVTSGGTGLGPRDLAIDTLAPKFTRRLPGVEQELLRWGQTKTRTAMLSRLAAGVIGNTVVVCLPGSTSAAKDALEVLVPAIFHAFPMLKGDGHA", "function": "Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).", "AFDB_id": "AF-P59014-F1-model_v4" }, { "swissprot_id": "A0L4N8", "sequence": "MSQTPMPQPDQAPPVDVGQPVDEAEAKRRRFKTHGRKKGKVNDTRLARIEAGLLALSLPPGSADRGALIDQLGGNGQSQRVILEIGFGNGETLAALAARHPEDCFIGIDVFLEGFGTLLNRLTRGDISNVRLVCQNALQVLLERIPDASLDGVIINFPDPWRKKRHFKRRIVQTEFLDALAPKMRSGADLTLATDWANYAEWMVAHLEPHTAFVNQAEPGPFAAPPPWWIETNFERKGVAAGRIIRHLHYKKR", "function": "Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.", "AFDB_id": "AF-A0L4N8-F1-model_v4" }, { "swissprot_id": "Q6FLY9", "sequence": "MSFIRIARSLARGYYNLPTNIIDRTSINTSRKDDDSDTKATGSQLDSPDEEWLKDYNSFVNVRRRNRSVLRTFVFGIGLFLIIAILTLWWPLTGADLPQCHSIYMYPSYARVDGFNEKFTSLANKYHLYLYREQGMDKEPLNNGEIQLDGIPVLFIPGNAGSYRQVRSIAAACSELYFKQSDILINKNAKNLDFFAADFNEDFTAFHGGTMLDQAEYLNDAIRYILSLYDQPDVSTTLAKPKSVIIVAHSMGGIVARLMPTLKNHIHGSVHSYLTLSSPHAAAPITFDGDVLQLYKRTNEYWKRELNDKSSFIFNNVSLISITGGIQDTILPADYAMIEDLIPYSNGFTVHTNTIQDVWTPIDHLAIVWCKQLREIISRYLVETSNIYLPSKVVPLEERMKIASQLFLSGFEDSYRNYSGEELRNLTTNSEVSSEMKLNDIVKITKDTIPDKPYLSVPVAQFDGNVFLTLFSNSDNIKILGCANSYRHDPTIHSCKDLSHFIKKVPRYFDPNKEHKTESNKLLHTSIDEFKKYDFVIVDFSTIVEEHDLLVYATLSREEHTVIDVTPSNLLFMSQKIKVPPGALMNKWEFINLWDSLFAYKMNVDTTAMEQPFEPFVKQHIKEPFETKWHLNVLESTTSISFHNIAPFIPTNENITRSLFLTLVGSPENDYFIRISVDYLMTLKLLYIRYRLAIASFPIAVITMVLAYQFYIYDRRGIFLPFVTALGHLISTYNTIICFSLLGLSFLCDMKLVQNALFAIDPSHLNKPYFNSNKDVRNNFYLLGLRSKLLGVLVYFFFTIGTALVILLNGILLTFQKLFTMAINLKRTNMLQNQRTNTTAIITKWRFLALFLIIISVSTFIPYQMAFMLAVIIQVINSLKVSSLSARTKNHQNLLNFNMSLLLLLIFIAIIDFPIIIVFLHNVAIRCGTSFRSQHNCLAIIPILLMVNNNSLLRLPNRTKGNKGRLVSLLGLIYLSLFSLIYGIRNLFWLHHGVNIFSMWVFYLTIFSKGS", "function": "Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.", "AFDB_id": "AF-Q6FLY9-F1-model_v4" }, { "swissprot_id": "O45876", "sequence": "MGYLLTIACYIASFSPSIALFCSFIAHDPVRIILFFLGSFFWLVSLLFSSLAWLGLSTVLPDTFLLSLTVCIIAQELSRVAYFMLLKKAQRGLNKITRQGQISVAPGVSDLHNARHMLALVCGLGMGVISALFYTMNAFAIFSGPGTIGLPNALKTGEIDTNRAGKYLPLCYTLSAILLTLFHVTWTIMVWDSCHKIGRIPSAFVPGAAAVVSHLLVTFLSSLNSRGFHVLVFAVQFLILLICIAYCNVIMGGTISSFVNGIGQSITDAVTLKQVRTLIEERKLRTQRQSVPDEPMTERAGTSNTVNA", "function": "Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2.", "AFDB_id": "AF-O45876-F1-model_v4" }, { "swissprot_id": "P40518", "sequence": "MEADWRRIDIDAFDPESGRLTAADLVPPYETTVTLQELQPRMNQLRSLATSGDSLGAVQLLTTDPPYSADAPTKEQYFKSVLEALTQVRQADIGNVIKNLSDSQRDVLVKYLYKGMSVPQGQKQGGVLLAWLERITQVSGVTPIVHYISDRRTV", "function": "Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.", "AFDB_id": "AF-P40518-F1-model_v4" }, { "swissprot_id": "P11792", "sequence": "MMNFFTSKSSNQDTGFSSQHQHPNGQNNGNNNSSTAGNDNGYPCKLVSSGPCASSNNGALFTNFTLQTATPTTAISQDLYAMGTTGITSENALFQMKSMNNGISSVNNNNSNTPTIITTSQEETNAGNVHGDTGGNSLQNSEDDNFSSSSTTKCLLSSTSSLSINQREAAAAAYGPDTDIPRGKLEVTIIEARDLVTRSKDSQPYVVCTFESSEFISNGPESLGAINNNNNNNNNNQHNQNQHINNNNENTNPDAASQHHNNNSGWNGSQLPSIKEHLKKKPLYTHRSSSQLDQLNSCSSVTDPSKRSSNSSSGSSNGPKNDSSHPIWHHKTTFDVLGSHSELDISVYDAAHDHMFLGQVRLYPMIHNLAHASQHQWHSLKPRVIDEVVSGDILIKWTYKQTKKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLKDRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAIDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTTASTSYMNKHQPMMTATPLSPAMQAKFAGFTFVDESAIDEHVNNNRKFLQNSYFMEPGSFIPGNPNLPPDEDVIDDDGDEDINDGFNQEKNMNNSHSQMDFDGDQHMDDEFVSGRFEI", "function": "Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity. Regulates ribosome biogenesis, translation initiation, and entry into stationary phase in a TORC1-dependent manner.", "AFDB_id": "AF-P11792-F1-model_v4" }, { "swissprot_id": "Q8CJM2", "sequence": "MIDRKALLNDLKQQVKAVEADLGKQVKALDEVGARLRAEYDQARKLGRTAATWNSWLDERVTQVAVAWVLGTVFVRFCEDNRLIPEPYVTGPDNYRRDLAETRYDVYVEADDDPTYRGWLRRAFAELGDGQAGRLLFDSDHNPLYQIPLSHDGARELVEFWRQRDEEGALVHDFTDPLSADGTEGWGTRFLGDLYQDLSEAARKTYALLQTPEFVEEFILDRTMNPAVREFGYEELKMIDPTCGSGHFVLGAFRRLVRLGGENQPGKDVHQRVRAALDSVHGVDINPFAVAIARFRLLVAAMAASGVRTLDEASKYEWPVHLAVGDSLIKSGSQQGSLFGESDDDLTDELAEFKYATEDVGEHPEMLRPGRYHVVVGNPPYITVKDKSLNALYRELYPACAGKYALSVPFAQRFFELAKREDAEGSGYGMVGQITANSFMKREFGTKLIEGYFGHAVELTEVIDTSGAYIPGHGTPTVILVGTRRGGDGRSPVIRTVRSVQGEPVAPENAEEGLVWRAIVEQIDKPGSVSQWVSVDDLDREKYFSKQPWVLADGGQEMLEQINAASHAILKRDLHRIGFYGIMGADDAMSAVPRTFRRNNAESEYVRRLVVGDEVRDFRIADGDDAFHPYGSQRDLVGPDAFPNLAAWLWPYRTELGGRATFSGGTYFADGRPWWEWHQLPKDVGAHAWSLNFAFVATHNHVVLDRSGCAFTRTAPVIKLREGASEEEHLRLLGLLNSSTAGFWLKMVSYPKGGDPVGDEGARVSVHPWSDRYEFTGTKLQEFPLPSEYPTGLGTALDALAQRLAAASPAAVAAEAVPIAGLLREARTRWEAIRSRMIALQEEMDWQVYSLYKLHSEDLRVSEDPDDTNIPELTLGGRAFEIVLARRVAAGEASDEWFKRHNSTPITEIPAHWPAPYREIVQKRIDAIESNRAIGMVERPEYKRRWATEGWDALQEKALRSWLLDRMENRDLWCDENGQPTILTLARLTDALSRDEDFASVAKLYAPRKELAKVVAELITDEHVPFLSALRYKPSGLKKRADWEEVWDLQRKEDAAPDEPAKRKIRDSIPVPPKYTSADFLRPSYWKARGKLDVPKERFVSYGQTNAATPELYGWAGWDHREQAQALATYFTNTALSTKEITPFLAGLLELQPWLSQWHNEFDMLYSGSPADFFAGYRQQKQGEHGLTDDDLRGWRPPAATRRRRAAAKQ", "function": "May be a subtypes G and alpha restriction enzyme that recognizes and cleaves an unknown sequence. Methylates an adenine residue in the same sequence.", "AFDB_id": "AF-Q8CJM2-F1-model_v4" }, { "swissprot_id": "B7Z8K6", "sequence": "SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKLGKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSCHKPKAIVHTEKVNMMSLTVLGLRMLFAKTVAVNFLLTAKLFFL", "function": "Constant region of T cell receptor (TR) delta chain that participates in the antigen recognition. Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair. Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells. Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements.", "AFDB_id": "AF-B7Z8K6-F1-model_v4" }, { "swissprot_id": "P39705", "sequence": "MHRKSLRRASATVPSAPYRKQIISNAHNKPSLFSKIKTFFTQKDSARVSPRNNVANKQPRNESFNRRISSMPGGYFHSEISPDSTVNRSVVVSAVGEARNDIENKEEEYDETHETNISNAKLANFFSKKGNEPLSEIEIEGVMSLLQKSSKSMITSEGEQKSAEGNNIDQSLILKESGSTPISISNAPTFNPKYDTSNASMNTTLGSIGSRKYSFNYSSLPSPYKTTVYRYSAAKKIPDTYTANTSAQSIASAKSVRSGVSKSAPSKKISNTAAALVSLLDENDSKKNNAASELANPYSSYVSQIRKHKRVSPNAAPRQEISEEETTVKPLFQNVPEQGEEPMKQLNATKISPSAPSKDSFTKYKPARSSSLRSNVVVAETSPEKKDGGDKPPSSAFNFSFNTSRNVEPTENAYKSENAPSASSKEFNFTNLQAKPLVGKPKTELTKGDSTPVQPDLSVTPQKSSSKGFVFNSVQKKSRSNLSQENDNEGKHISASIDNDFSEEKAEEFDFNVPVVSKQLGNGLVDENKVEAFKSLYTF", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).", "AFDB_id": "AF-P39705-F1-model_v4" }, { "swissprot_id": "Q9ERD6", "sequence": "MDLMNGQASSVTIAATVSEKSSSSESLSEKGSELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPILPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGASTPRSAASREDLAGPDIGASPQGGRKSSAAAAAAAAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSATFPNAGPRHLLDDSVMEPHAPSRGQAESSTLSSGISIGSSDGSELSEETSWPAFERNRLYHSLGPVTRVPRNGYRSHTKASSSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVVGWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGSRMNAMLWFKHLSAACQSNKQQVPTNLMTFE", "function": "Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion.", "AFDB_id": "AF-Q9ERD6-F1-model_v4" }, { "swissprot_id": "A9GHW2", "sequence": "MGDLSNRARKILFAAVTEFIATGDPVGSRTLARKYGLDLSAASIRNVLADLEEAGYLHQPHTSAGRIPTDRALRLFIDALVELRSLSPEQQAELSARFTEIYAGANDPLRETGRYLSELSGAAAVVAAPRAELRALAQLRFIPTKPGQLLAVLVFADGSVANRFISVDEAINEGELTRIHNLLTDVIEGRTLGEIRDLFARRLADERLQIDALRRRAFELGSKATADVTPRSEVVIEGQNRLIDLPEYADVDRLKKLMKALEEREELVDLLDRTLAAGAGEVTVFVGSEAGDLGGGQLSLVAAPYMENGRVAGTVGVLGPTRMDYAKVMPLVDATAAAMTEVRGKVK", "function": "Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.", "AFDB_id": "AF-A9GHW2-F1-model_v4" }, { "swissprot_id": "P47074", "sequence": "MKAYAKKRISYMPSSPSQNVINFEEIETQKENILPLKEGRSAAALSKAIHQPLVEINQVKSSFEQRLIDELPALSDPITLYLEYIKWLNNAYPQGGNSKQSGMLTLLERCLSHLKDLERYRNDVRFLKIWFWYIELFTRNSFMESRDIFMYMLRNGIGSELASFYEEFTNLLIQKEKFQYAVKILQLGIKNKARPNKVLEDRLNHLLRELGENNIQLGNEISMDSLESTVLGKTRSEFVNRLELANQNGTSSDVNLTKNNVFVDGEESDVELFETPNRGVYRDGWENFDLKAERNKENNLRISLLEANTNLGELKQHEMLSQKKRPYDEKLPIFRDSIGRSDPVYQMINTKDQKPEKIDCNFKLIYCEDEESKGGRLEFSLEEVLAISRNVYKRVRTNRKHPREANLGQEESANQKEAEAQSKRPKISRKALVSKSLTPSNQGRMFSGEEYINCPMTPKGRSTETSDIISAVKPRQLTPILEMRESNSFSQSKNSEIISDDDKSSSSFISYPPQR", "function": "Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20.", "AFDB_id": "AF-P47074-F1-model_v4" }, { "swissprot_id": "Q4WKX0", "sequence": "MTVNGKDIDSPNAQYVAAGIDMSDLFPAPFPTNVKTVHLETLSLAKLLQRDEDELRRIYENCKDPGFFQLDLTDDEQGVQLLQDAVDCARLMKQLLPNMSVEEKRMYKQHSRVGVYSKGYQVYDVLPNGQPKYNETVNFPMTEMLGYGDSTVDLPDWLSPHRELFQRTMRSGNKIANIVLAALEVGLQVPRGALTDAHRIQDPSDDFLRLLRYPGLQPGQPRDDLCFPAHKDFTSLGILFTWLGGLQLLASASAPGVTSGTMTGPLDIAEDAWRWVQPVPGTAIVNVGNALEILTNKALTSGLHRVVRAPGEQLPFDRYSVLVGTRPANSFPMKPLQSPQISPVLDPAAAEIATMTSGQWGTHNIGSFNNWVKARTERQEVLIIP", "function": "2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of fumigermin that inhibits germination of spores of the inducing S.rapamycinicus, and thus helps the fungus to defend resources in the shared habitat against a bacterial competitor. The partially reducing polyketide synthase fngA alone is sufficient for the production of fumigermin. FgnA catalyzes the condensation of 3 malonyl-CoA units to an acetyl-CoA starter, and 3 methylations to yield fumigermin. It is remarkable that the five cluster genes including fgnA are conserved in distantly related fungi, supporting the assumption of a fumigermin cluster; it is thus possible that originally all five genes were functional, but that the genes encoding tailoring enzymes became inactive from mutations, similar to the case of the fgnA gene in strains A1163 and Af293 (Probable).", "AFDB_id": "AF-Q4WKX0-F1-model_v4" }, { "swissprot_id": "P53509", "sequence": "MKKTIGLILILASFGSHARTEIATKNFPVSTTISKSFFAPEPRIQPSFGENVGKEGALLFSVNLTVPENVSQVTVYPVYDEDYGLGRLVNTADASQSIIYQIVDEKGKKMLKDHGAEVTPNQQITFKALNYTSGEKKISPGIYNDQVMVGYYVN", "function": "Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.", "AFDB_id": "AF-P53509-F1-model_v4" }, { "swissprot_id": "O29918", "sequence": "MDRKVLMLAVILFALAVRFQNFGEIFDSGIYYTGYDSYYHMRLVEVMVKESFRPDYDYYINYPFGLKITWPPLFDYILAFPGMLFGFHSSEIFAVFLPVILGVLSVVLICLTALQIVNNQTFALISAFIYAAAPVAVWKTVLGQADHHALVIFLFLLSAYLLLKDGVWKILAGLPMLFMALAWLGSPIYGALLAFSALVHFDRKALRLVAASYLIPAISFVLYPPVGISFFGLAAFLFVGSVVKGYEDRFRNATIYYIALSLATVLIIYFIPLPHFEFVKGGINYIFGANIYLPTISEARSLQIFEIISASGYIYFIFALISVLFFRNRFVLSMFFLSFILALMQLRFTEVLVVPSALLSAYLVSLVLERLEYPVFEKADEEEKSRRRKRKDRKVKQKNAEVEWKDHAVVAAFLVILAIPCIVVAVVPFDLTEDWKEALEWMRTSLEEQNYLNPYEKPEYSVMSWWDYGNWILYVSKKAVVCNNFQAGAVDAAKFFTAKSEDEAIKIAKKRGVRYVVTADEITMKDANNTKFPAIMRIAGYNVDLMTEGEILNFFNHTVLYRLHMENAENLTHFRLVKEFGDVKIFEVVGS", "function": "Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (a GalNAc-linked heptasaccharide composed of 4 Hex, 3 dHex and a sulfate for A.fulgidus AglB-S) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.", "AFDB_id": "AF-O29918-F1-model_v4" }, { "swissprot_id": "Q9RWM1", "sequence": "MLPLTAAITAGGASSRFGSDKALALWQGRPLLDQVAAGLAACERRLLIAPPGKYALPGWETWPDTRPGEGPLAGLEVALTHAAPGWVAFTGVDNPALTSDYWLTLLAACRPGMSSVQALHPERGPQPLGALYHTALLPRVTGLLAAGERRLRLTAPAEQTVLVTGLGAHFFQNVNRPADLAELSGRGEESLEV", "function": "Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.", "AFDB_id": "AF-Q9RWM1-F1-model_v4" }, { "swissprot_id": "A0A120KVR5", "sequence": "MGLPFLCHTRVCLFSNKIPFVLCGSRFAPATLHAHHTAAGGGETLNFPELSSPSTSKEPSVGSDSPQKKNKKQAFDALARWCGGHQQLLMRIQQSAEDTSAGVVFETPLTEVDSAAIRWLQGSTEQLTCGQSLLVCSFVCEVLYCQLNSASGGIGVEEAQRLQIHALTNRIAALLQRADESNKLESQPLSVLMSCAYVVQRLKYVDNPLFGETQRSLVKVPPSIMFALLHKLRGDGLGKLFQLDERTATDVCLSFLFIATEEHRQAFFSSGDAALVSNVLRRLVRYTASKTRRMRIQKEGDIIDLLTVDSPSDGGARQTPVCTSGTGFTSPSMRECAMIMQNVSFSSPSNRLELLLYLLCVRRNLAQCSLKDIELVPTVLSTVANIRSAEACSIRKKIISQLWLPENNPTLVAQLLVHSGESIPRYVTYLQGVPASKLSPRDAAQVILCAGTYLSYESLQLYIMAALRDIMPSSSLVTLGAETTSASVPATASVPTRVPACDSLETVLSVLLMRVEEKGGSLSEVEKDACMEYIRRLNELIDWCASAPTSSPKPALQRLTLLTKLFNRGLVVHAPETVVELAVQSLQLDPGNTMMNTLKCVSEALPLVSDDKKRSIIIEKMISYSGTRTTSSVIRFLLLLAPLVDADSPHSCELVEQLLKFHTLNPHKLRQASVEGVAKGIDVYTLLLINGIDFLLASGDWRSSPSQLQNVITTWVRDYTLYVMDPARKQKIDDGAAAHVAPATKGEKTDVVQHQQPSRLNEGGELPTLSGPNDEELEQVFTCLLRAGVKLPHAFSSELLSRIRRLQAKRNPADGTDQQVVFPLPAHFVFCCKLDVPVEVSVTPEMMKYHIDACDYRIIHCVITAFFSAAGTFKHNINDLLLCNMRLASRSFELFIQRLGEEASRSFRPATVSSVVANTLRFVVNHITKQERCQRVLRKLNEKGGIEAGEEELEGDRSLIAEHTRLGELLTRMIAYLSGAHVKNVGLSVLDRLSLLSPACGEYLMMRLSTQLSEFTQVELLYLVQKYPKSQDLVAELLGKSDLVSSMDFGDYMRVMRNLPMPINALVIGAHLPGLNFQWCTRILSSLSVRHESVPLHLLASVLRRLNDVTESATLTDRNIAFVVLQKYLQFDQTSGDGGDLEERQRLIKCSCDKLLVLSRINSLDTLKEFLVEFPEALSGVICESLSKHVVQHIVGGLLKDLDGLLTLCRLLHRHKLLTSDVKVAIVDGFFMKTLQSEVEGRANIEGESSQGLQPLNSVRGASLKTTHPVSNVLALALLLSDGPLHFPGASNSSSTICGDNERCAVSSMFQVVKESYTSPRDRLLIANTLVGQKGPNALTVVAKEICTELIENCESVTSNDFSRLLQCISRLKCWSELDLANSRFDEVFQRSCTQADAHSRCVAFRAVSFEADIFRRYESFMIPLLQETVDVMSNEDLETVLSSVLSLPFTEALESLIDAIGTRLLRMIDQCRRSALIRLLQCHAAFGIQDDALVSVCVATLTDQCGRDFRLDTAQVLALLQAAVDLDFFLPPKLVTSCFTWLEHHVENMTITQLGHAVRLAVDVEVGYTAAVHTLTLRALEQRDAIRSNASFREAVEMLCDEFSAEIPWHLRAPVLRRRYQSERLLEYLDKRRLAVDSTVA", "function": "As part of the mitochondrial 3' processome (MPsome), involved in the maturation of guided RNA (gRNA) precursors.", "AFDB_id": "AF-A0A120KVR5-F1-model_v4" }, { "swissprot_id": "Q1IZN3", "sequence": "MTDGLPERFDVLVHPVSELRGELRAQPSKNYTTRYLLAAALAEGETRVVGAATSEDAEALIRCLRAWGADVDRVGEDVVVRGFGAHPRAGMTLNPGNAGAVARFLMGVAALTTDTTFVTDYSESLGRRPQGDLLAALERLGARVSSRNGQLPVTLSGPVRGGRVEVSAQRSSQYASALMFLGPLLPDGLDLRLTGEIKSHAPLRQTLDTLAAFGLQARASADLTRITIPGGQAYRPGRVLVPGDYPGSAALLVAAALLPGEVTVTNLREGDLQGEREALNVLRAMGADLVREGDRVTVRGGRPLHAVTRDGDSFTDAVQALTAAAAFARGTTTWENVATLRLKECDRISDTRRELERLGLTATETADSLSITGADRIPGDLTADGHGDHRMIMLLTLLGLRAEAPLRITGAHHIRKSYPLFFRHLEELGAHFEYLPTDAA", "function": "Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.", "AFDB_id": "AF-Q1IZN3-F1-model_v4" }, { "swissprot_id": "O35622", "sequence": "MARKWNGRAVARALVLATLWLAVSGRPLAQQSQSVSDEDPLFLYGWGKITRLQYLYSAGPYVSNCFLRIRSDGSVDCEEDQNERNLLEFRAVALKTIAIKDVSSVRYLCMSADGKIYGLIRYSEEDCTFREEMDCLGYNQYRSMKHHLHIIFIQAKPREQLQDQKPSNFIPVFHRSFFETGDQLRSKMFSLPLESDSMDPFRMVEDVDHLVKSPSFQK", "function": "Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.", "AFDB_id": "AF-O35622-F1-model_v4" }, { "swissprot_id": "Q9DG36", "sequence": "MACQRHLLFLLLVLFAVSTQLSHGQHWSHGWYPGGKRELDMPASPEVSEEIKLCEGEECAYLRNPRKNLLKNILGRSNQKKNADVLARQLQKK", "function": "Stimulates the secretion of gonadotropins.", "AFDB_id": "AF-Q9DG36-F1-model_v4" }, { "swissprot_id": "P61727", "sequence": "MSLPMTETVTDPAETAPPTAERSYPRFAKPQRVAFVQSSWHRDVVAGCWESFVREIVERGIVASQVDLFEVPGSFEIPLHVQMLAKTRRYTAIVAAGLVVDDGLTGFVAQTVIQALMDVQLKTEVPVFSAVATPHSFERGSPNTEHFRQHFATKGADVAHACADTLLSLERLRGQVAAGIV", "function": "Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.", "AFDB_id": "AF-P61727-F1-model_v4" }, { "swissprot_id": "A0A0A7HGA1", "sequence": "MTYKLYIMTFQNAHFGSGTLDSSKLTFSADRIFSALVLESLKMGKLDAFLAEANQDKFTLTDAFPFQFGPFLPKPIGYPKHDQIDQSVDVKEVRRQAKLSKKLQFLALENVDDYLNGELFENEEHAVIDTVTKNQPHKDGNLYQVATTRFSNDTSLYVIANESDLLNELMSSLQYSGLGGKRSSGFGRFELDIQNIPLELSDRLTKNHSDKVMSLTTALPVDADLEEAMEDGHYLLTKSSGFAFSHATNENYRKQDLYKFASGSTFSKTFEGQIVDVRPLDFPHAVLNYAKPLFFKLEV", "function": "The subunit probably binds to the 5' handle of the crRNA, helping in discrimination between self- and non-self.", "AFDB_id": "AF-A0A0A7HGA1-F1-model_v4" }, { "swissprot_id": "A2BK57", "sequence": "MENGAVQQLQLLGKRVKGFGVGGRYVAHPYYSGRFRELLGCTPFPGTLNFDANLDWRELASMCEPQVIPGTVWDGVRLGAVYVWKAKIMTRHGYVDCAVIRPLLSGHPPTVLEIVACEKLEPILENNPDKTVIVTIACKRGDALRWRRY", "function": "Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).", "AFDB_id": "AF-A2BK57-F1-model_v4" }, { "swissprot_id": "Q08562", "sequence": "MAAVPTIDLTLADSDNEDIFHSFSSSTSVDKIDIRKENGKLRMAGLEVAQSNDDAARQAFHVFKTNISNNETFDTILSKSKTITDSTFNNEKSSNEVKQQQVLKEETMGSSNDEKKTQESSPSAEMIKLFYENDDVPLSDSFKQKEEGKRINQDEQVKENICGISSSYVSKDYDGVEDDFEPNTCQDSNLDFQEEKLNLNNKPSQQQFSDPETKDNSLKSENKDQIKGVTTTSYRDLPIESSAFQDSETQNNSKNTIPNIVNEKRTPALPSNLSSVESSLKNETAKVEGKTTVRLPGLQNNVALLEQEQSELFKHFSEQPVDISDFGRKIKRKHSGDFADNKILKRPILPSKNMDHTTHNSHDSEQKNSSIIILSDEDESGAGINDIESPLKVSEPNTADALRSSVPEVISLLDLPNIDLNNSVIKEASGSNSIPTSETDAQSSSSSVLQGTIMTEQATQSSQHECNSSLDTLKKNHQKLLKDLNSRESELRNALSCCKTNSEILRRKLSRREKEVSDAEKHWQLLLTSMARGGRTISSTQQILVDEAENQLNKLKEKRQLTKSKLDSINLKMYNYNEQWKSFVHSKNINLQKSLAALERSARDSKASATVNKRNECLAEKEKLDQMLKEGTLSFSTYKQLTGEIQQKLNDLKLGDQRTTDINSVLPIVRQPLAKRDLFIKSIDTAKDLLAKNTSRTEMTKRILYRHLDNLVSYKNFFEDGRSLIDINRRHVAHESAQILFTNGVKMPIVFETLQDYGIKFSNPAIVNPDRRAQYFKSIEVARDLISKSTRSEDAKRKITRFLNIIEEFRKDIDTGFPPTPLKREGVGKAVVGLRQQGLKMDRLYENLRRYKIPITSEELLQQSYLFPVNADQRPPSNWNIVENTEDTSSTANDLSMQDEFHISNMHAAEDQEQIRALLENVKQSESIIDGEALTPEDMTVNLLKHQRLGLHWLLQVENSAKKGGLLADDMGLGKTIQAIALMLANRSEESKCKTNLIVAPVSVLRVWKGELETKVKKRAKFTTFIFGGSGNGKVKHWRDLARYDAVLVSYQTLANEFKKHWPKKLDGEQNQLPAVPHIQALNRLKTSNEYYSPFFCNDSTFYRILLDEGQNIKNKNTRASKACCTINGMYRWVLSGTPIQNSMDELYSLIRFLRIPPYHKEQRFKLDIGRFFQRNKQYQYDNEDRKNALRKVRVLLNAIMLRRSKADKIDGKPLLELPPKIVEVDESRLKGEELKFYTALESKNQALAKKLLNNSTRGSYSSVLTLLLRLRQACCHSELVVMGEKKAEGTKVANGKSFEDDWLRLYYKITHMSGEAQAQVITSMNSMTCFWCMEQLEPEAMSVLTGCGHLICDTCIEPFIEESSMLPQAKKTKGGAFAIPCKDCQRLTNEKDIVSHKLYDQVINQGFTEEDLHAEYLSEMEKQKIQQKNVYVPNFESLEPSTKIEQCIQVIQRVFDESATEKIIIFSQFTTFFEILEHFLKNKLNFPYLKYIGSMNAQRRSDVINEFYRDPEKRILLISMKAGNSGLTLTCANHVVIVDPFWNPYVEEQAQDRCYRISQTKKVQVHKLFIKDSVEDRISELQKRKKEMVDSAMDPGKIKEVNSLGRRELGFLFGLNAL", "function": "ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.", "AFDB_id": "AF-Q08562-F1-model_v4" }, { "swissprot_id": "P91929", "sequence": "MTAVFRVGLVRLVSRATQSPNLLQAQTNALPAAFQQRCSISGKTMRGGPRVPKAAPYPYKTKKYSVFNAIFDKTSKRFDENSKVICVEGPIAAGKSKFAKELAEELDMEYYPAVDLDLIYINSYGYDMRKLDPQLPPSCRSYDVRNFCLDPSHDLAAQFQIRMYMLRYSQYIDALQHVLSTGQGVVLERSPYSDFVFMEAMFRQGYLSRGARSVYNELRQNTIGELLKPHLVIYLDLPVDAVKKQIKARNVDYEVQSKVFSDAYLSDLEQLYKQQYLKDISTHAELLIYDWTAGGETEVVVEDIERIDFNQFEADIHNKKMLDWRFPLEAEWCEARIKYCHEKPDLMNYFNVPRFDVPELVRSADDGKVWRDVWFNAPGMKYRPGYNADMGDEGLLTKTKIGINQGI", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.", "AFDB_id": "AF-P91929-F1-model_v4" }, { "swissprot_id": "P35202", "sequence": "MSEECIENPERIKIGTDLINIRNKMNLKELIHPNEDENSTLLILNQKIDIPRPLFYKIWKLHDLKVCADGAANRLYDYLDDDETLRIKYLPNYIIGDLDSLSEKVYKYYRKNKVTIIKQTTQYSTDFTKCVNLISLHFNSPEFRSLISNKDNLQSNHGIELEKGIHTLYNTMTESLVFSKVTPISLLALGGIGGRFDQTVHSITQLYTLSENASYFKLCYMTPTDLIFLIKKNGTLIEYDPQFRNTCIGNCGLLPIGEATLVKETRGLKWDVKNWPTSVVTGRVSSSNRFVGDNCCFIDTKDDIILNVEIFVDKLIDFL", "function": "Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP).", "AFDB_id": "AF-P35202-F1-model_v4" }, { "swissprot_id": "O04846", "sequence": "MKIMMMIKLCFFSMSLICIAPADAQTEGVVFGYKGKNGPNQWGHLNPHFTTCAVGKLQSPIDIQRRQIFYNHKLNSIHREYYFTNATLVNHVCNVAMFFGEGAGDVIIENKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTEEPFLSQMKEKLVKLKEERLKGNHTAQVEVGRIDTRHIERKTRKYYRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPLDTSFKNNSRPCQPLNGRRVEMFHDHERVDKKETGNKKKKPN", "function": "Reversible hydration of carbon dioxide.", "AFDB_id": "AF-O04846-F1-model_v4" }, { "swissprot_id": "Q03782", "sequence": "MRPRRRGLAYHHTKPKGQLSQGHYPTTSNDGQRRKVGNSEAFQSFDIWKNLDRIRSTKKNAGQFIKGSLLILPMRTEDKQQFDECMDELHKYISKDILRCYPQKEQKDEGMLFYIVLKDFNILDSCFVLSVLLAFQKRLWMAPSEKSYFRVPKNINLTGSFYLPKNIETGRGHIITSYRREQPSSSIVEVGFNVVPDFQQFQVKACHVSKFMNELSNFFSQVEFGKCEANVINYFKREYNRTYSQISLALYELPLIGDGLFDIKSYISKTRPIIETSKAQMIKHISEMKAYNEISGLQGDQFPRQQRPLSNSPSSNSISSSQTIEAGATSYQTQPQRHAVNKPSNVLNSSNRHSGPKTFEDGRYSEGNKPGFMTQDEIKQHCIGTIKASMDAVKKKSSYQILKTYVRCPRQNYIDIVYQNLNDLRSKTNCNIVVLNLNNLHESQMWLESLNTTNYTIFAQAPHPSTIRVISIGGVGEYIVKALELILNILEH", "function": "Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.", "AFDB_id": "AF-Q03782-F1-model_v4" }, { "swissprot_id": "P95481", "sequence": "MERTLDRVGVFAATHAAVAACDPLQARALVLQLPGLNRNKDVPGIVGLLREFLPVRGLPCGWGFVEAAAAMRDIGFFLGSLKRHGHEPAEVVPGLEPVLLDLARATNLPPRETLLHVTVWNPTAADAQRSYTGLPDEAHLLESVRISMAALEAAIALTVELFDVSLRSPEFAQRCDELEAYLQKMVESIVYAYRFISPQVFYDELRPFYEPIRVGGQSYLGPGAVEMPLFVLEHVLWGSQSDDQTYREFKETYLPYVLPAYRAVYARFSGEPALIDRALDEARAVGTRDEHVRAGLTALERVFKVLLRFRAPHLKLAERAYEVGQSGPEIGSGGYAPSMLGELLTLTYAARSRVRAALDES", "function": "Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin. Catalyzes the ring rearrangement and decarboxylation to convert 7-chloro-L-tryptophan (7-CLT) to monodechloroaminopyrrolnitrin (MDA). It can also use 7-chloro-D-tryptophan, but 7-chloro-L-tryptophan is the preferred natural enantiomer.", "AFDB_id": "AF-P95481-F1-model_v4" }, { "swissprot_id": "C4K7V2", "sequence": "MIYQSLFSHQASLPSEQLPFTVILLNDWGLIRVTGKDRVKYLQGQITLDVPLLKENQHILGAHCDPKGKILSTVRLFHYLKGLAFITRKSLLHDELMELRKYAVFSKVEIDIAESTVLLGIAGDQARKVLKNCFEKLPTETEPVVHEDDYSLLHFSSPRERFLLVSQAFKEGDFLIQKLQDQAVFRSSEQWLALDIESGFPIIDAKNKTQFIPQAANLKALGGISFTKGCYTGQEVVARTEYRGVNKKALYWLTGKACRVPDVGEALEIQMEEDYRRTGVVLAAVKLQDGSLWVQAILNHDFQKDSILRVKGDENGRLMISHRSFKKFEPSSNPIA", "function": "Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.", "AFDB_id": "AF-C4K7V2-F1-model_v4" }, { "swissprot_id": "P0CU71", "sequence": "MSYTWLITRASSGRGAAIALAALEAGHKVIAGARNPAKASQVRPEIQNQGGTWLRLDDSTADVRHVIAKAAKEHGLNVLVNNAGGYALRGVLEDFSETELYQQMETNFFGPIRAIQGALPWSRAQKPGTIFNISSTSDITGFTGFSLYAASKAALEGASEALYGELALFGIRVLVVQPGASRTKFQSAGPRPAVSEACVGTTVDAILQRAVGMAAERR", "function": "Oxidoreductase; part of the gene cluster that mediates the biosynthesis of the bianthraquinone cladofulvin, a conidial pigment not required for virulence but that plays a role in fitness and resistance to environmental stresses including UV light and low-temperature stress. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) claG. The atrochrysone carboxyl ACP thioesterase claF then breaks the thioester bond and releases the atrochrysone carboxylic acid from claG. This compound is decarboxylated by claH to yield emodin, which is further converted to chrysophanol hydroquinone by the reductase claC and the dehydratase claB. The cytochrome P450 monooxygenase claM then catalyzes the dimerization of nataloe-emodin to cladofulvin.", "AFDB_id": "AF-P0CU71-F1-model_v4" }, { "swissprot_id": "P0A1N1", "sequence": "MQHLDIAELVRSALEVSGCDPSLIGGIDSHSTIVLDLFALPSICISVKDDDVWIWAQLGADSMVVLQQRAYEILMTIMEGCHFARGGQLLLGEQNGELTLKALVHPDFLSDGEKFSTALNGFYNYLEVFSRSLMR", "function": "Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.", "AFDB_id": "AF-P0A1N1-F1-model_v4" }, { "swissprot_id": "A7IB66", "sequence": "MQLDRIAQDLVAALRFYSRLPLPAGRDDPDAFAVPSLNRIAYAIPLAGAVIGLIGAVVLVGALALKLPAFLASVLAVTALVLTTGAFHEDGLADTADGLGGGRDKAQRLAIMRDSRIGTYGGCALILALLLRVAALEALVASAGMFRAALALVVAEAASRAAGVLLLLALPPARADGAGASFGRPSESAGLACALVAALLVVVILVPGFGISTAFAGLIAPLVALFAMMRLSGRLIGGQTGDVAGATQQVAVIVFLLGVLIFPGR", "function": "Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.", "AFDB_id": "AF-A7IB66-F1-model_v4" }, { "swissprot_id": "Q9BVW5", "sequence": "MLEPQENGVIDLPDYEHVEDETFPPFPPPASPERQDGEGTEPDEESGNGAPVRVPPKRTVKRNIPKLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRLDLPILHEDFVSNNDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR", "function": "Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.", "AFDB_id": "AF-Q9BVW5-F1-model_v4" }, { "swissprot_id": "Q07683", "sequence": "MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLEALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLITFIRTKRKVQEELS", "function": "Transcriptional repressor for the ans operon coding for L-asparaginase and L-aspartase. NH4(+) may influence this repression.", "AFDB_id": "AF-Q07683-F1-model_v4" }, { "swissprot_id": "Q568D5", "sequence": "MNSLSPELALSRISPELRPLLCSIVRNGRVGLDSSSCLRITDLKSGCTSLMPGPCCDRFKLHIPYAGETLKWDIIFNARDPELPPDFIFGEDADFLPEPSELPNLVSWDSGKPECLLLLVKEMLQQYHQYQCQRLRDSSRLLFEYDSLLEDPNYGRNMEIYAGRKNSWTGEFSARFLLKLPVDFSNIPIYLLKDTALDPGEDVALLSVSFEDAEATQVFPKLYLSPSIEHALGGSSALHIPAFPSGGCLIDYVPQVCQLLTNKVQYVIQGYHKRREYIAAFLSHFGMGVVEYDAVGFTKLTLLLMWKDFCFLVHVDLPLYFPRDQPTLTFQSIYHFTSSGQLYSQVQKSYPYSPRWDGNEMAKRAKAYFKSFIPQFQEGAFANGKL", "function": "Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the brca1-bard1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.", "AFDB_id": "AF-Q568D5-F1-model_v4" }, { "swissprot_id": "P45459", "sequence": "GSGTPTEAQTQPQQGGAHERVDLPGNMADALSQQQGQVDAATQGMTGAASTLPTAPATVMSGAAAREATRPVQGTAPQQHKTPAKTAAAKPTATQHKSPTTVYTPPAKPSSTAKAGAVASSGSSVQSAPGSHYTLQLSSASRSDTLNAYAKQQKLQNYLVYATKRDGKPWYVLVSGNYASSAEAKRAIASLPADVQAKKPWVRPVHQVQQDLKK", "function": "Non-essential cell division protein.", "AFDB_id": "AF-P45459-F1-model_v4" }, { "swissprot_id": "A0A166Z003", "sequence": "MPDNHGPWGLRWRAKPSFILTTVAMGLFTDLVLYGILLPALPFTMRNRFDIPNAEIQHYTSAFLATYAGASVFFSVPAGWAASKLGSRQLFLGGLMFLVVATAIFAFSTSLVLLVVSRLLQGMSTAVVWTAGLDMVQDTVEPSQVGETIGTIFATISVGELAAPVLGGVLYERGGISAVFAVSAVLLAIDLALRALVIDKKTAVKYESPRLIRFPVERNMSDDHVASAPTVMEAQESVHEGTRLLPQVDDDGDHYKIDRELGSIVRAIPLLYCFREPRLHLAMLLSFVQALFIGTFDATVPTVAESLFHFSSLQVGLVFIALMLPYFALGRLSGQAIDRFGTKAAATSGYAFLVPCLMLLGLPEKNLVPKEANVALFCTILALNGIGLAVVTSPGYVEAIDVTTKYQVANPGHFGENGPYAQLFGFSSLYFFTGLAVGPLLGGFLRANFGNAVMGAVYAAISGVTAIVSFLFVGVRRFGPGLV", "function": "MFS-type transporter; part of the gene cluster that mediates the biosynthesis of pyrrolopyrazines, secondary metabolites showing insecticidal activity. Probably involved in the secretion of peramine and other pyrrolopyrazines (Probable).", "AFDB_id": "AF-A0A166Z003-F1-model_v4" }, { "swissprot_id": "P40086", "sequence": "MLFRNIEVGRQAAKLLTRTSSRLAWQSIGASRNISTIRQQIRKTQLYNFKKTVSIRPFSLSSPVFKPHVASESNPIESRLKTSKNVAYWLIGTSGLVFGIVVLGGLTRLTESGLSITEWKPVTGTLPPMNQKEWEEEFIKYKESPEFKLLNSHIDLDEFKFIFFMEWIHRLWGRAIGAVFILPAVYFAVSKKTSGHVNKRLFGLAGLLGLQGFVGWWMVKSGLDQEQLDARKSKPTVSQYRLTTHLGTAFFLYMGMLWTGLEILRECKWIKNPVQAISLFKKLDNPAIGPMRKISLALLAVSFLTAMSGGMVAGLDAGWVYNTWPKMGERWFPSSRELMDENFCRREDKKDLWWRNLLENPVTVQLVHRTCAYVAFTSVLAAHMYAIKKKAVIPRNAMTSLHVMMGVVTLQATLGILTILYLVPISLASIHQAGALALLTSSLVFASQLRKPRAPMRNVIITLPHSSKVTSGKILSEASKLASKPL", "function": "Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin YAH1 and ferredoxin reductase ARH1.", "AFDB_id": "AF-P40086-F1-model_v4" }, { "swissprot_id": "G5EEI4", "sequence": "MQTFVLLALVAACSAAVIQVPTHKTESLRAKLIKEGKYTAFLASQHAARAQQLNTGFQPFVDYFDDFYLGNITLGTPPQPATVVLDTGSSNLWVIDAACKTQACNGYPDSGYTKQKFDTTKSTTFVKETRKFSIQYGSGSCNGYLGKDVLNFGGLTVQSQEFGVSTHLADVFGYQPVDGILGLGWPALAVDQVVPPMQNLIAQKQLDAPLFTVWLDRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAKTYWQFPLDAFAVGTYSETKKDQVISDTGTSWLGAPNTIVSAIVKQTKAVFDWSTELYTVDCSTMKTQPDLIFTIGGAQFPVKSVEYVLDLQLGGGKCALAVFSMGSGGFGPSWILGDTFIRQYCNVYDIGNGQIGFATAVHKGL", "function": "Aspartic protease, which is part of the necrosis cell death pathway. Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells. Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) levels leading to lysosome rupture and to the subsequent release of asp-1 which leads to necrosis.", "AFDB_id": "AF-G5EEI4-F1-model_v4" }, { "swissprot_id": "P28805", "sequence": "MAKGKDVRVKVILECTGCVRKSVNKGSRGVSRYITQKNRHNTPSRLELRKFCPYCYKHTIHGEIKK", "function": "Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.", "AFDB_id": "AF-P28805-F1-model_v4" }, { "swissprot_id": "P9WI26", "sequence": "MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLYELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG", "function": "Induces pro-inflammatory responses.", "AFDB_id": "AF-P9WI26-F1-model_v4" }, { "swissprot_id": "Q8VY63", "sequence": "MDYLGIDMSCAIGSLRNGDFPEKDCLLPLISKLLGYCLVAASITVKLPQIMKIVQHKSVRGLSVVAFELEVVGYTISLAYCLHKGLPFSAFGEMAFLLIQALILVACIYYYSQPVPVTTWIRPLLYCAVAPTVLAGQINPTLFEALYASQHAIFLFARLPQIWKNFKNKSTGELSFLTFFMNFAGSIVRVFTSLQEKAPISILTGFALGVVTNGSILTQILLYSKPAAAKEKKAN", "function": "Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.", "AFDB_id": "AF-Q8VY63-F1-model_v4" }, { "swissprot_id": "Q4P2W8", "sequence": "MINFFGGKAPTAAQPASSTSTAVNGARFASVSTSSSASASAAGQPPLKKTKIAPSPVTVVTTVKKKVAPPTSVEPRDPIAALSGYNSKNALPEEKRRRIIEERLAAQRQKSIESSLEAQLRAPTKSLSKSQSASSTSRRSAASFSKPKTKKPRKKVVDSDSDHDEFGDYGKSSRKPSTAPSTPRASKRTSVDPHPTSDSYQKVGRDGVQPNYTVPRDIRASTSPTNTTAIPIDTQSRPSKPISSADIVTANIKNYGPYFNGLGDAPRAVLEYPGTDASEEFLLLVPKDADEYDPLMELLATVRAIVTHYLTPEQRKAFGSLDSLEVSNNAGMILPSATHGASASTSAVCNMVAALTDSNGINGARAKSADLLDGQGSKAERRNHLVGAGTYKDTGSMTPEPHANGISQTAPVSPTSQTSGISASAGGSSVAKTVLVNNALLRLDSPAPTELSVASDHSSTPAASCGTDPDSILRSFTKARNRRDGPLFMRTLARFNSALAALRDTGALAANIADLGSCTGVPEGIWRLIQDQVYARVVGPRVEELGRYQAFSDNVYGELLPRFMSEIAQLTLLGPEKVFVDLGSGVGNLLIQTSLQTGAEAYGCEMMRIPASLASQQVVEAQLRWAAWGLRGGSAIEAWQGDFGDHGGVRDVLKRADVVLVNNYAFLPKTNENLSLLFLDLPDGAKVVSLKPFVPPDFRLTQRTLSSPLAILRVTERLYTSGCVSWADGGGKYYIQEVDRSLVREFLQNAGAATRAKRGKVSEGDDTVAASDLMVGQDVRRKRWKAALQDDDEDDDEF", "function": "Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.", "AFDB_id": "AF-Q4P2W8-F1-model_v4" }, { "swissprot_id": "Q08642", "sequence": "MQPPIRENMLRERTVRLQYGSRVEAVYVLGTQLWTDVYSAAPAGAKTFSLKHSEGVKVEVVRDGEAEEVVTNGKQRWALSPSSTLRLSMAQASTEASSDKVTVNYYEEEGSAPIDQAGLFLTAIEISLDVDADRDGEVEKNNPKKASWTWGPEGQGAILLVNCDRDTPWLPKEDCSDEKVYSKQDLQDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRQKLYHVVKYTGGSAELLFFVEGLCFPDESFSGLVSIHVSLLEYMAEGIPLTPIFTDTVMFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYMNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPIKQLLGPDFGYVTREPLFETVTSLDSFGNLEVSPPVTVNGKEYPLGRILIGSSFPLSGGRRMTKVVRDFLQAQQVQAPVELYSDWLTVGHVDEFMTFIPIPGKKEFRLLMASTSACYQLFREKQKAGHGEAVMFKGLGGMSSKRITINKILSNESLTQENQYFQRCLDWNRDILKRELALTEKDIIDLPALFKMDENHQARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLETHVRGLLEPLGLACTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP", "function": "Catalyzes the deimination of arginine residues of proteins.", "AFDB_id": "AF-Q08642-F1-model_v4" }, { "swissprot_id": "D4GYH0", "sequence": "MKRLAKAAFSQNSLTAPIVSTFVYLISVVRVVLNGNWPVTSSDTAMFQHIGWMVFSGKRYYIDAWDPKPPLTLELATIIAYISNGDPHLQHTLSVVSTIVAGILLTYLISHITSEITGNQFAGLLSGIVFITFPVIHYSAVFGYEPKYFVFLFGLGSIYLSRNPKPILSGAAAAASAGMWQFAIIFPIISFGIISRRKSKDLILKYVFGATIIAFISLLPIYLQGGLVAMTVEVIIAPLYAGETQSFLYRLVKGVTHLKLMIPIALLGMAGILLGFLDDIRERWWVVGLLLWFCIQIFILDYDGADDLFLGIILVSMGIGFAFEKLSTKYESERINSIVTAVVVCMLIWQVVTLGGVGVITNPYSYSGDGPDQAILESGIQQFAHLSGYTEYTIGGSPPDEQYNVKSRYGPDKIEELFFTSTIPSTCHYRLSGMELEWMNLTEQSFTEEKCGKWRLP", "function": "Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Transfers mannose, the terminal pentasaccharide residue, from its dedicated dolichol phosphate carrier to the protein-bound glycan comprising the first four subunits of the N-linked pentasaccharide.", "AFDB_id": "AF-D4GYH0-F1-model_v4" }, { "swissprot_id": "P20779", "sequence": "MLDAFSRAVVSADSKTAPIGGDDLNQLRSFIASGNRRLDAVNAIASNASCMVSDAVAGMICENTGLIQAGGNCYPNRRMAACLRDAEIILRYVSYALLAGDASVLDDRCLNGLKETYTALGVPLQSTARAVAIMKAQAAAHIQDNPSEALAGAKLRKMGTPVVEDRCASLVAESSSYFDRVIAALS", "function": "Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex.", "AFDB_id": "AF-P20779-F1-model_v4" }, { "swissprot_id": "P0ABT9", "sequence": "MSAAGKSNPLAISGLVVLTLIWSYSWIFMKQVTSYIGAFDFTALRCIFGALVLFIVLLLRGRGMRPTPFKYTLAIALLQTCGMVGLAQWALVSGGAGKVAILSYTMPFWVVIFAALFLGERLRRGQYFAILIAAFGLFLVLQPWQLDFSSMKSAMLAILSGVSWGASAIVAKRLYARHPRVDLLSLTSWQMLYAALVMSVVALLVPQREIDWQPTVFWALAYSAILATALAWSLWLFVLKNLPASIASLSTLAVPVCGVLFSWWLLGENPGAVEGSGIVLIVLALALVSRKKKEAVSVKRI", "function": "Involved in response to cystine.", "AFDB_id": "AF-P0ABT9-F1-model_v4" }, { "swissprot_id": "O97101", "sequence": "MEELIKAPNSNFIIMSNQPYQTTSPEIVEDYIIKRGQPFVLTGTTQGWSRSNMFTLDFLSERYSEMELINSPRNNETHTDLQGWRMKDFISYLQVSPEERNPKHLYGKDIACPREWQEYLSHKLQPQYSYKSRFDLVSHLPDYLQPETLLVYIGSNGTYTPGHIDMCGSLSQNLMVSSDQDAFAWWFIVPTEYKDEALKFWGDKGGDVYNESRFIRPIDLLGAPFPIYVFKQRPGDFIFVPPDSVHQVVNCGPGISTKVAWNSISLKSLPISYFSSLPHTRRMAKPELFRIKAIAYYTLRKIMGDVENTNFNTIDVNDVIDIIAPLLEIFHNILQTESILIPKPNYPYCNGETIPFLQPFKYFNGDRIQDRRCDHCNSDIFNRCYHCETCKTDDGQGKDFCFDCVSSGIGCEFHFKVMVLKEFISHSKLKKELSSFYEIYKNLLAHSGRRPKEVDDIITKSTDRVSDECGFLTTATVAYHVVFYSSQKKIKCHRCEKRFKKFSIIFCTNCNARFCEQCVVNTFGQNFQVLMKRNEWECFCCKGLCDCSNCTSNSNSSNHPRILNNNQQLGLPYNNNNNSNNNNNNNINNNNNNNNNNINNNNNNMNNNNSINNNNNNNNNNNINNNNINNNNHHNNNGNNNLNSSYSSLNALSSLSQQQSYGSYDNYNNNNNNNNYNNNNNNNGHIQILKSGRQYDDEQSSSSGSGSSNSTPTKPRPRNGGDDGLMSHFSGNNNNNNNHHNNNNNNNNNHHMMSHHHHNNNNNNNNNNNPTTSSLSSLSTSLSSSSTSTQKPMDVHSKKRPIVLDNDKPKGRPPKNLKEWTSTHKFIISLIELFRSSNNAILGKPNPHYKPIENLPPLVQLYLSQRKAFGGVLWAKTNSCPLLPCIWVKDLSVIPPNTKLLPSLIQGKKIVVLFFGDQDQEEYVGIVGKKSIFSFDEVNQTLLLKCGEVPLAQLEDLFNTTEPEIAMKKDIAAFNYKNQIEEKEEGLYVKQELYNNKKII", "function": "Transcriptional regulator involved in phagocytosis and pinocytosis. Both activates and represses transcription. Regulates expression of acaA, carA, pkaC, csaA, cotB and lagC. Promotes amplification of the tRNA gene-associated retrotransposon TRE5-A, a mobile genetic element formerly called as Dictyostelium repetitive element (DRE). Suppresses agnC and agnE encoding argonaute proteins which are part of a RNA interference pathway controlling TRE5-A amplification. Required for amplification of both sense and antisense RNA transcripts, but does not activate their promoters found in A-module and C-module of the TRE5-A, respectively. Nevertheless, binds to distinct DNA sequences containing A and T stretches within the C-module in vitro.", "AFDB_id": "AF-O97101-F1-model_v4" }, { "swissprot_id": "Q9WYH8", "sequence": "MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN", "function": "Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).", "AFDB_id": "AF-Q9WYH8-F1-model_v4" }, { "swissprot_id": "P38018", "sequence": "MEKIQKITYKELVAEKVNDFNTTFVIEPLARGYANTMGTVLRRTLLSSITSVAPFAIKINNVEHEFQTISGLKEDAITLVRNIRNIRFVYNEEIFEKENLAKISFKTNKEGEIFASDIPEVSGLEIVNKDQYIANIAKGGSLEFDLFLRKGRGFIDFEENKNVISQYGSRLESSIKNGQFLAMDSDFSPVKKCAISFEELNSSSKLIEERLKIKIETDCTVSAKEAIEQAAKIIVAHFQIIGNINALETIELFEENKEKKEREIKSTTPITKLGLSVRSENALRRAKYNTVEEVLGLSDEELSNIKNLGKKSIQDIIEKRNEWKERIGYDDGQSDNFIIESLDQLNNSEEGEE", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "AFDB_id": "AF-P38018-F1-model_v4" }, { "swissprot_id": "Q12236", "sequence": "MYFDKDNSMSPRPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSNRNVGDLLLEKRTAKPMIQKALTNTDNFIEMYHNQQRKNLDDDTIKEVMINDENGKTVASTNDGRYDNDYDNNDINDQKTLDNIAGSPHMEKNRNKVKIEHDSSSQKPIAKESSKAQKNIIKKGIKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLDRRLTISQIKEHHFFKDLNFKDGSVWSKTPPEIKPYKINAKSMQAMPSGSDRKLVKKSVNTLGKSHLVTQRSASSPSVEETTHSTLYNNNTHASTESEISIKKRPTDERTAQILENARKGINNRKNQPGKRTPSGAASAALAASAALTKKTMQSYPTSSSKSSRSSSPATTSRPGTYKRTSSTESKPFAKSPPLSASVLSSKVPMPPYTPPMSPPMTPYDTYQMTPPYTTKQQDYSDTAIAAPKPCISKQNVKNSTDSPLMNKQDIQWSFYLKNINEHVLRTEKLDFVTTNYDILEKKMLKLNGSLLDPQLFGKPRHTFLSQVARSGGEVTGFRNDPTMTAYSKTEDTYYSKNIIDLQLLEDDYRIEGGDLSELLTNRSGEGYKCNQNSSPMKDDDKSESNNKGSSVFSGKIKKLFHPTSAAETLSSSDEKTKYYKRTIVMTSFGRFLVFAKRRQPNPVTNLKYELEYDINLRQQGTKIKELIIPLEMGTNHIVVIQTPYKSFLLSTDKKTTSKLFTVLKKILNSNTNKIEKELLQRNQKVIERRTSSSGRAIPKDLPTSKSPSPKPRTHSQSPSISKHNSFSESINSAKSNRSSRIFETFINAKEQNSKKHAAPVPLTSKLVNGLPKRQVTVGLGLNTGTNFKNSSAKSKRS", "function": "Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step.", "AFDB_id": "AF-Q12236-F1-model_v4" }, { "swissprot_id": "O14772", "sequence": "MRAVRRGLREGGAMAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSGGYSQRLPNASALGKIFTALPLGNPIYQMLELKLAMYIDFPLNMNPGILVTCADDIELYSIGEFEFIRFDKPGFTALAHPSSLTIGTTHGVFVLDPFDDLKHRDLEYRSCHRFLHKPSIEKMYQFNAVCRPGNFCQQDFAGGDIADLKLDSDYVYTDSLFYMDHKSAKMLLAFYEKIGTLSCEIDAYGDFLQALGPGATVEYTRNTSNVIKEESELVEMRQRIFHLLKGTSLNVVVLNNSKFYHIGTTEEYLFYFTSDNSLKSELGLQSITFSIFPDIPECSGKTSCIIQSILDSRCSVAPGSVVEYSRLGPDVSVGENCIISGSYILTKAALPAHSFVCSLSLKMNRCLKYATMAFGVQDNLKKSVKTLSDIKLLQFFGVCFLSCLDVWNLKVTEELFSGNKTCLSLWTARIFPVCSSLSDSVITSLKMLNAVKNKSAFSLNSYKLLSIEEMLIYKDVEDMITYREQIFLEISLKSSLM", "function": "Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.", "AFDB_id": "AF-O14772-F1-model_v4" }, { "swissprot_id": "Q9Y7N2", "sequence": "MAQAPEYHYVGSVDYQPTRPSAHQNLIELYGLTELAKKVGRVDEFGNKRKMRRSYKAYIQDLPGYNEILRDNTIKQWLTNPIREEVPIDIEFLHHVFSVEPGIIPGFNPKVFGLEDDVVMGNVSRDSSQPRSPSRRKK", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.", "AFDB_id": "AF-Q9Y7N2-F1-model_v4" }, { "swissprot_id": "O60174", "sequence": "MGPKSKEYENPSSYKNDEDNDDDGDFVLENVMSEEDIEIETPSRNRKRVSTTRRTPSKPIRSQPLTPSSSKGAGNEPKSQNSSTTRGSAKKQSSKGLEEKLINSYGTHVESLNKGRRLIEIWKYYETAPGQSSFEGQTSSDSKLQTLLNLDGQQLLSYSENPFYLFEVKNLSISFHFESPQQVEPCQPVNPFKENPQKSGFVVNTGIPLSSVSWLPTNKETQFLAVGGMLKFSETTESVFMRTSGRNQIQLWKLENKTNFKSEFILYHDWGSVLQLEWCPTISVEDSILGFLAVVCSDGKLRVLRVPRSPVKFHVFVEQADFTFGFNDSLISCCTWVSPEHGDIHQILVGCSNGYLALWDILSSQECPLFYIPYHDSYIHNVVQCLDDFPWLFLTTAFDCYTRIFDIRDPIIDNRPLSHKRDICYTITWNNMLQSIISCSESQSVVIESLRGTSTQLLDERNGSIISLSNSKFHPFVACAASDGIVTIVNPFRLLGFSHKQKANVHRIFQLEYSEKQDSYRMLDGFRPRLPKAKKLDMYIYPWQIQVNKVEWNGNKGYAGWLASGMACGILRVEDLSAVERR", "function": "TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with sfc3 in DNA binding. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.", "AFDB_id": "AF-O60174-F1-model_v4" }, { "swissprot_id": "P32030", "sequence": "MVKSEMEFKSNFSIDAILAKKPINTATQPIKTEPVHHHHQYVHPYSNSDGELSASEDFDSPSRTSTPMSSAAESLSSQNNDKLDVEFDDELEDQLDEDQESEDGNPSKKQKMTAGSDTKKPPYSYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFKANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKLRRKNPGASRTRLAAYRQAIFSPMMAASPYGAPAPSYGYPAVPFAAAAAAALYQRMNPAAYQAAYQQMQYQQAPQAHHHQAPHPAQMQGYPPQLNAELFQRMQFFGKFPSS", "function": "Transcription factor involved in segmentation. Required for the formation of the mandibular lobe. Different levels of slp activity seem to be required in different segments.", "AFDB_id": "AF-P32030-F1-model_v4" }, { "swissprot_id": "D4AS70", "sequence": "MVTLPLLLSILPLAAVFSSAASLQVRENHDCASIQPPQVPGAEILSVIGVQRRVEVAPFPPSPSKPNTTIDICSVNVTLSHMGVNDKVVVSVWLPLPDKWNGRFQATGGGGWAAGTFDLLMGPAALEGYSTAGTDAGVTVDPGSADKWALKEDGTVNYDLLENFASRSIHDMAIVGKAVTESYYKKPANYSYFYGCSNGGRQGMVEAQKYPDDFDGILAGAPAIYWPQFLTSTEWPQVVMQSEKVFPSQCVFEAFRKAGIAACDKLDGVEDGVVSNLDGCEFNPFALVGKKVKCGEESTTITLAQAWVAKKIYDGPKSTAKHALWDVLPVGASYVGLANSTIENGVPKIAPFVIGSSWIRSFLKKDVNFDLSTITYADMPKLFQQSIDEFDKIAGGSNPDLSALKKSGTKLLSWHGLADELIHPQGSIKYRQAVEHRMGGGSEVDNYYRLFLAPGVTHCGIGVNDGAAPIDTLKVLVRWVEKGEAPETMPATATDASGTTTLFTRNLCRYPLVPRYKGGDKNSADSFECAKDFGSHH", "function": "Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds.", "AFDB_id": "AF-D4AS70-F1-model_v4" }, { "swissprot_id": "Q02234", "sequence": "MTGKQHQKHEQKARQAQVKAQINRDKARSKLLRQREKLARRRARNRRQSEVRRGNQSKAQHDTQSETQRGTQSKSQRDNETGGTKNPTAHSTLPPQKTNAENAVRNSHSTVPELPKYSSVPARERLYGLRLHRETTASEDKSVTVAVTRAPKAERQRGGADE", "function": "May play a structural or regulatory role in gas vesicle synthesis.", "AFDB_id": "AF-Q02234-F1-model_v4" }, { "swissprot_id": "Q7N561", "sequence": "MSDWSGSVPANAENGKSTGLILKQGDTISVVAHGWVKYGRDNVEWAAPDGPVPNNPQPSSIATLVAKIANKKFAIGNGVLHKTVPVDGELILLFNDVPGTFGDNSGEFQVEVIIESRYSPLK", "function": "Lectin that specifically binds alpha-galactoside-terminating glycoconjugates. Shows high apparent binding to the alpha-Gal epitope (Gal-alpha-1,3-Gal-beta-1,4-GlcNAc terminating glycans) as well as to Gal-alpha-1,4-GlcNAc and Gal-alpha-1,3-GalNAc. Gal-alpha-1,3-GalNAc may be one natural ligand bound by PllA both in the nematode symbiont and in infected insects.", "AFDB_id": "AF-Q7N561-F1-model_v4" }, { "swissprot_id": "Q559A9", "sequence": "MENFKYRNNENDVAIIGIGFRLPGCKNFTPNELWNNLKNGFNGVVELSNRWSDNFYTMGKVSSAYAGLLPFDELKSFDPLFFGINPTEVPTIDPQQRILLKCTWEAFEDAGIDPIKIRGSNTSVFIGTSTNDYQRIIREKDQTITNAFGTSLHATSNRISYCFDFRGPSMTLDTACSSSLNCVKLGYQSIRDGTSNLSIAGGVNLIIDPYFTASISDLNILSKTGSCKTFDASADGFARAEGSGIIVMKNLKQAMIDGDKIYCVIKGASSNVDGGGLQDKSNFYAPSSLSQCNNIKMALKSTNGTVEPKDISYFECHGTGTPTGDPIETRGISMVFNDESRSKENPLLIGSIKSNIGHLEAGSGIASLIKCCLMFKNKCFAPNINFKVPNPKIKFEEWNLKVVTEPIQFTKSNTCIGLSNFGVTGSNCCLILSQFNNNNNDNQIVGNNNNIKSNKEYLIPFSSNSVKSLENYQQLLIKNGENEFKFLEFIKHQIFTKPTSLYQRSVVIASSWDQFNNAKIMKTSNSKSSNISIERNNPITVFVFCGQGSQYDRMGLELYNNDFIFKESMDLLDNKLSKYYGYSVLEKLRNCDSKSIQHPMIAQPVMCMFNISLFELYKHWGIEVSFIIGHSLGEIPAAYCSGMINIDTLCYLIYHRSIAQTKTHTNGRMLSINISADEYFSQYSKQYPDIEIACFNSPTSIVIAGNEQKLNEISEILKEKGIFSAMLASLSSFHTSSQNKVKEDIVNKQFDSKQSEIPIFSTVTTNLFDSVTSPFNSSYVFNNIVSPVKFSQTISNLYKHIESNQLGNDIVFIELAPHPTLQFYLKQMIPKPTNDDNSIEFKVSVYSALNKKNNDIEEIQRTISQLYCDNGYNVNFKCQFQHDDTHGSINSNINQLSNISLPHYQWDDEKYWKEDPSISKLIVNGPQTDNLGYLNENSPNSKSYETFIDIKRPPFQYLKGHMVKGKYYFPGCGYIDNLLKIYKSQDLTINQMGFKSPLIFIEGVNQALQTNIFKKSTSNTTTNNNDEFRVEYHFNDQKTNRWILSSFGDFQLSNHSSNSDNLEKINIKQLIQNQCNLTKLSRDELYSHIKSKTGLTYNGVFQGVNKCYLGENCSLSEVSLELKREPSSFFNTAVLDTCLHGMLCLLEEQSQLVFDRIEGFKYHSSNVPTSEEEMKIHSNIYVYSTINPSRIGDSYSASIVIMMEDGTVLIEIENAVCTSLTPIKESISVKYPTNQLFSMYLQSKDSPIPSPLNFKSLYNQNQQQLKIDKQFTDWMQKCEKFISNQFFKNIEKRNPEINLEILNSKTIIELKSKYCQNLKNERLFQFVFETIKQLGVNAYDDDDDLTIDSSEDRKSIYEILIKSTKVIPKLLFPLEDEDLTIDSPQSLFENGLLDRFYNNPNLMTNQCQLIAQIIKESLKPLLNKKMVFRILEMGGGTCSLSVVVLNLINQLLLENPSFEIDIEYTWSDISPSFISAAKEKLSHIDKRINILYRSIDIEQPFIEKQDLSPSYYDFVIMSNVLHVVKKLSPSLDEIHKILTPNGHLLFVEIPYKELISDSIFGAFNQWWAFEDTDIRKDRCSIPPNQWIQVLSNHNYKDTIVSDNKECTWCCFVIHSQKPSLLELSKKIECNQYDNIIVFGNENSQDNFTKSIKLSYNNNIIKWVSNIVEIKKFIKLNIITNNSIIYFTKGIEELTIDNFKLINFQYIQINQLLLKYESKCKNVLVTRDCDGSNYLASSLIGAARYFDEYRQLELFTLDFDNDTIQSCDECSSSSCSNLIKLIEPLIDPKINIQREFLIRNNRVYFERAKLETNLKKSFKSESFENSNKLISTLNFNLDYQLQSKPFKQLLQNEIEVEIKATGINYRDYLVFTGSLPIEKTNHNGISNQPEFGVDFSGIVTKVGGGGGNGEFKVGDRVYGIGHNTTSSHITIDSRYASLIPNSLDYIEASSITSSYILSLYGIFDIGNLDIQDNESILIHSGTGGIGLSALNSLRWKGHKSHLFVTVSSKEKEQYLRDNYGSFITGIYSNKDKNYPKLIKEKLNQLGSNKQGVDLILSSLPNGDDNLNFKCLAKNGRIIDLSNNIDLFNISKSKIKKLLNTINDGFESGELQVIPIIEFSNSNIRDAIEFINERQHIGKIVISHDDSNLLIDLINKHSNQPNYSILKSDYQISQSNLGKNILITGQSGIVLEILKWIIKFSNSIENVIILSKSLMKWELELLIGKTMKKANNKIKFHFKSVDVSDSIQVENSINQILNDNPNIVNIDSIFHFAFTQITKKVEEIDMESLNVSHNAKTIGAINLHNQSINRNWRLNNFVMASSATSIIGSTDQCSYVCANTVLDSLSKYRKSIGLPSICTNYGAIESAGFVSKNESVAAMFNGIGIISISTDLILGTLDLQIQNQQSSTNLMLSDFNFLNFVNNNLQLSLISKFDFQTNLAKNQVNEKLQNQTQNQNLQIQSPSSTTDCQTIIKDSFLHKISEVLSIDISKLNLDLKLLDYGADSLAIVQIKNWIDMEVSPNLIVIQQLQTFTITSSIQYTINSFLKKKVQSQE", "function": "Probable polyketide synthase.", "AFDB_id": "AF-Q559A9-F1-model_v4" }, { "swissprot_id": "Q9LN09", "sequence": "MVSSKKPKEKKARSDVVVNKASGRSKRSSGSRTKKTSNKVNIVKKKPEIYEISESSSSDSVEEAIRGDEAKKSNGVVSKRGNGKSVGIPTKTSKNREEDDGGAEDAKIKFPMNRIRRIMRSDNSAPQIMQDAVFLVNKATEMFIERFSEEAYDSSVKDKKKFIHYKHLSSVVSNDQRYEFLADSVPEKLKAEAALEEWERGMTDAG", "function": "Transcription factor which promotes the expression of heat stress-inducible genes by contributing to the formation of a heat stress-specific transcriptional complex with NF-Y subunits (e.g. NF-YA2 and NF-YB3) and DREB2A at the promoter of target genes, thus promoting heat tolerance. Together with the glyceraldehyde-3-phosphate dehydrogenase (GAPC), enhances heat tolerance.", "AFDB_id": "AF-Q9LN09-F1-model_v4" }, { "swissprot_id": "O25094", "sequence": "MKKNYSYKNIQAIDFTNLNDGEKLLVLEFRNHPNTALWMYSTFISLKTHLQFIEDLKNSPNHRYFLFKEEGVYLGVGSITKINFFHKHGYLGIYKNPFLKNGGETILKALEFIAFEEFQLHSLHLEVMENNFKAIAFYEKNHYELEGRLKGFISKDKEFIDVLLYYKDKKGYNDQSLLKL", "function": "Catalyzes the third step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates N-4 acetylation of UDP-4-amino-4,6-dideoxy-beta-L-AltNAc to form UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose.", "AFDB_id": "AF-O25094-F1-model_v4" }, { "swissprot_id": "C0Z787", "sequence": "MQKRAISSRFSEKAVSYEKYALVQKKMADHLSQMVTEITNENDVRSILEIGCGTGGLTRVIRSYFSAAHYEAVEIAQGMLEQAKNNLEQHGLICSFSQADAEEWVWEQQAKSKDLIVSGACFQWFARPAHTLRGLARILKPGAPLVFSTFGPDTFWELHDSFTNAHAILGEKGVRHGLEFLSARDWHEQLEQAGFTDIEISRKYERLTYPGVRDFLHAVKAVGASVSMEQGSGLGRRKLLAEMIRYYEQTYKRETGIPVTYEVIYVRAVSSRAVTFFK", "function": "Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.", "AFDB_id": "AF-C0Z787-F1-model_v4" }, { "swissprot_id": "O06553", "sequence": "MARQVFDDKLLAVISGNSIGVLATIKHDGRPQLSNVQYHFDPRKLLIQVSIAEPRAKTRNLRRDPRASILVDADDGWSYAVAEGTAQLTPPAAAPDDDTVEALIALYRNIAGEHSDWDDYRQAMVTDRRVLLTLPISHVYGLPPGMR", "function": "F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo. Binds coenzyme F420, but does not bind FMN or other flavins. Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'-phosphate (PLP), the anti-tuberculosis drug PA-824 or aflatoxin analogs as substrates.", "AFDB_id": "AF-O06553-F1-model_v4" }, { "swissprot_id": "Q9VXE6", "sequence": "MEDAQEQRESSQAELAKKHPLTPLKELPEESEEEEEEEDESSAGALRESDSNNSIMGKMKMRVSSILPASLSGWFSPSSKDGNDALSSPANLRQSQPRQSNGRLTTKRKRGRRRIMLAEVDADAADDLDDGSDAKGLNYEEVALADNIAEHDLAAEDEQTRRSEYNVFLLRKRAGAVAAAGGDEDEAEEDELEEDDEDGDEEDDDEEQENLQQSAAVQTKRRRLELETPVNLPNMRRLPLLSSTPAAPLAAATSSSSSQMYKGVSHIAPHRRNHLNLYGSQRQREPAYNFFTGNEAAEGSTGDLPHSIRRSLNIPFGGSSTATSYNNSLSSLPNHKRPSLIGKQTHRRDLTMDETGTGPAMSSEEHLNHLLRISRTNNNTSNNNNNNNNNNNVIETKTRRSELSAAAGGCGDSQSESDMNEYHDNGEGHDGLRPSHYNSNSNLEFYGNLQSSKSIFNRSNTAAQQSHRNSTWSLNSLTQRRRFNASIYGSTSALSDSRLLSGSASNSGSASASSSPFYQGRTTFGGNSGNNRLFSRSNLSSSAASSMLGLNSAGSSPAHQLHASMTGGIGYGMKAVDMRPSDSGSLAETSVGQGGSKKPGTGLSNTTMRILNLLESYSTPLIDAKRMGSSIKEHQSSRQQRQGTPATPYLRSTSASRNVSVPNHINELAELRSNKLLVPTMQQLLERRRLHRVTQNSRDVVHSQNVRAGGENNQEKPKPTAPYVAPIDQSANHTQHTNKMRSRLSHQTRNKETRTAEEEAPPPLDLPQISFPDMASAPKFDLIIKPTVPVVSKPSTTDPIQSSKSSNTNLSTTNSKQMPNFLANPQPAAPIVNFAANGNVSAISKPSKRTFTFSEPTPLSNFQENCIPKPKINRKYTFSAPAPLDDLRITNKQSQPTINGTPSSKEWECDTCMVRNKPEINKCVACETAKPVASAAPVQAPLPPSTAAIDTQSFVGFGDRFKKSTTAWECDACMLSNKAEASKCIACETPRKTVAPKVNNFSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPGATMALPATSNIAVATPSIITDGFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIANSSYPSINNNLPAGSGFDISFTRKANMWECQTCLVMNKSSDEECIACQTPNSQARNSNSESALISSISSSSASFSGSLSRPSSRSSSGSTSTCGSVCSGSIVSISSTTESAKALSAKKVPPKPDAGFQQLVAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNPAATTANSAASSVPKFRFGFSHVKEVVKPSVETTTTPAPTSAQFSFGFGQSNQGKDVADSKKTEAPKTFMFGVSKVEEPKTVSFGTGIKETTATSSTEATAPTPAAAAPAPVQFVFKAPTTATTASSLTTTISTTSNAPALGGFSFGAPSSSSTVSSSTTSTSANPAAVKPMFSWSGAGSAVSSTSSSQQPVAKAPTLGFGVSSSTVTTTTTSTKVFAFTPASGLDPAAATSAPAAGAGFSFGSQSKPATTQNTGTFFFGQPTAVAPATPTNPSVSSIFGAPATSTTASTSVSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTTFGASSGSGTTTTPSFGWSSNGDAAKSNSAAVGSAAVPSSSASTMATPIFGSSSMFGPSSSSNNTTSTSTTSLPFGSAATTAATTPAGGNAALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIFGNPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAPALPGAFNFGGATAATPAASSAPFVFGSSTNEPLAKPSFNFTGSAASSTAPAPAFNFTANTAATNNPSGGDSTPNANALFQFSATSTAPANIFAFNPPAAGNSAQSSQTARRKIRAPVRRLPPR", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy. Preferentially binds to NARs of the male X chromosome. In males, together with Mtor, required for the localization of the male-specific lethal (MSL) histone acetyltransferase complex to the X chromosome and therefore for the transcription of dosage compensation genes. May play a role in double strand break DNA repair.", "AFDB_id": "AF-Q9VXE6-F1-model_v4" }, { "swissprot_id": "Q9UW13", "sequence": "MRRAVSKILPTPKLFNDSAHFHSNFRLEYNSVDDFYVQLDNPHKVWLPGEEISGQVVLISKKNLANIVITLSLVGFIKINASSHSKLRPLKHTLFDYTIKIYGKDEEEQTDSAEFSNGLLKGEHVFPFIVKLPNKRVYTSIDFGKGSINYILKAAIGNSSSYVIPASPDNASTSSLTKKKILQNPSHTSEKVISLVNPIDVSLLPRPKPKRLILKDPRTSSNKKLSRTQTSTSTINTMSSNEHDHSLPEGATPEDSDHKSLKSIPVPTIKAILEVPQRGYLRGESIPIKLSINHLRKIQDFNGIIITFVRVCRLDNGPDGVVESFRKDLQQLILPLYVDPVTFQSEINSSLRVPADAFPTILGCPLVSFQYFVEVLINLSGKSIALDSDVDARAKANPQATKSSSDKFKFNFDSTQTERSTYINTDSYKRSKKFLQLTTEIYIGTHRSSTQEEQAPQAEEVASRRSSSMASNSNSSPAVFSTSSPHSPVEHQYAGAINSIPESVAVSNFTPPYENVVPSYVPPEFVSHLQNQSELSEKERMRQHESSLLPSAPPDDEQPSPVNMTSNQQPFSFFTYQNTNTSPPVPLDDDLYQEPVDSAPNYLNVNNDRLIVPQDNNSNSET", "function": "Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. Required for hyphal development.", "AFDB_id": "AF-Q9UW13-F1-model_v4" }, { "swissprot_id": "Q96EB6", "sequence": "MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS", "function": "(Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection.", "AFDB_id": "AF-Q96EB6-F1-model_v4" }, { "swissprot_id": "I1R9B6", "sequence": "MVKILPPTASIDWDQISIATNLGLGHVESTYHMSTGRWSDPVFVNDPYLRVHGLAPGLQYAFRTPKGRVSIFRPDKHAKRMSHSTSTISIPNIPESLFLASVELAVTSNSSYVPPHTSRAMLYIRPFAFGSSEMIGLVPPSEYKFCVYVKPVPAYHGLSAQDALILTGFDRAAPHGLGHAKVGGNYAPVIKWSEQAKADGFGMTLHLDSKTRTEIDEFSTSGFLGIKVSDEGAVKVVAPSSPCIIDSTTSDCCLQLARHYGWNVEKRPIKYTELPEFSEVVAVGTAASVVSIRSITLEDSRETVRYLDATTNQGRYARKLSTSLDDIMHCRVEDVFGWCHQVGEAPVEDVPTRKMGSSNKKPAFVDIMTLSCAGQGARFSCH", "function": "Aminotransferase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves. The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).", "AFDB_id": "AF-I1R9B6-F1-model_v4" }, { "swissprot_id": "Q5PP37", "sequence": "MDSVYKTDENFAADVAALLAPLPTPQLQEYFNKLITSRRCNGIEVKNNGTIGKGVYANSEFDEDELILKDEILVGIQHSSNKVDCLVCSFCFRFIGSIEKQIGRKLYFKNLGVSGCCDDDSSEEDECVKYNGNEEQCGGSSSSHNTLPEGVVSSLMNGEMALPHTDKFPLPSPLSCPGGCQEAFYCSESCAAADWESSHSLLCTGERSESISREALGEFIKHANDTNDIFLLAAKAIAFTILRYRKLKAEHVDKKAKQSEPKQSLLLEAWKPVSIGYKRRWWDCIALPDDVDPTDEGAFRMQIKNLACTSLELLKIAIFDKECEALFSLEIYGNIIGMFELNNLDLVVASPVEDYFLYIDDLPDAEKEETEEITRPFLDALGDEYSDCCQGTAFFPLQSCMNHSCCPNAKAFKREEDRDGQAVIIALRRISKNEEVTISYIDEELPYKERQALLADYGFSCKCSKCLEDSSSI", "function": "Histone methyltransferase that methylates 'Lys-36' (H3K36me) of histone H3 to produce H3K36me3. Promotes early stages of cellular dedifferentiation through H3K36me3-dependent, and to a lesser degree H3K4me3-dependent, activation of Lateral organ Boundaries-Domain (LBD) (e.g. LBD16 and LBD29) genes. Positive regulator of root organogenesis including lateral root formation as well as adventitious root formation from wounded leaf tissues. Recruited by JMJ30/ARF (e.g. ARF7 and ARF19) complexes to promote the deposition of H3K36me3 and, to a lower extent, H3K4me3 at LBD genes promoters, thus ensuring their stable activation during callus formation on callus-inducing medium (CIM).", "AFDB_id": "AF-Q5PP37-F1-model_v4" }, { "swissprot_id": "Q5MQL3", "sequence": "MKFFVLFAILIAIVHASCASVPKVVYDGPIYELRQIEEENIEPDTELMDSNEPLLPLRHRRVTCDVLSWQSKWLSINHSACAIRCLAQRRKGGSCRNGVCICRK", "function": "Antibacterial peptide mostly active against Gram-positive bacteria.", "AFDB_id": "AF-Q5MQL3-F1-model_v4" }, { "swissprot_id": "Q8KY01", "sequence": "MTTSLALYLALGCGLAAVLYGFIQRGWILAQDAGNARMQEIAGAIQQGAAAYLARQYKTIAIVGAVLAILIFFFLGGLTAAGFVLGAVLSGACGFIGMNVSVRANVRTAQAATKGIGPALDVAFKGGAITGMLVVGLGLLGVSLFFWFLSGGIHADPATLKPLLGLAFGSSLISIFARLGGGIFTKGADVGADLVGKVEASIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTLIAAMALGALLLPNAALAAAVYPLVLGGVSIIASIIGCAFVKASPGMKNVMPALYKGLIVAGAISLVFFFFVTRMVMPDDALGAGTQMRLFGACVVGLVLTAAMVWVTEYYTGTQFKPVQHVAQASTTGHGTNIIAGLGVSMKSTAWPVIFVCLAIYGAYALAGLYGIAIAATSMLSMAGIVVARDAYGPITDNAGGIAEMSGLPDSVRDITDPLDAVGNTTKAVTKGYAIGSAGLAALVLFADYTHALEARGMSLSFDLSDHRVIVGLFIGGLIPYLFASMAMEAVGRAAGSVVVEVRRQFRDIKGIMEGTAKPEYGTAVDMLTTAAIKEMIVPSLLPVVAPILVGMLLGPAALGGLLMGTIVTGIFVGISMCTGGGAWDNAKKLIEEGFTDANGVLHKKGSEAHKAAVTGDTVGDPYKDTAGPAVNPLIKIINIVALLIVPLLPLASNPVKASHAEPAPMVQPAETAPAMPAAPMAEPSAPAASQ", "function": "Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.", "AFDB_id": "AF-Q8KY01-F1-model_v4" }, { "swissprot_id": "P51892", "sequence": "MQRTIKSFFQPKLGAEVKTKEEKVKNDVQKEKEEPEKSVPERPLKERNGRALCGDTESPVKRVSKKSARVLESDSEEEEENSKVQATPEKMNNESDPKNDVKETPPSARKETPPSARKETPPSARKETPQSARKETPPSARKDAKSEGASEMNTSQDFVSPCSSKSIDSPLCSDSPGISPSGIPKRKTARKQLPKRKLEISPSESNPPKDDFDVKGAVKRQKKEAEGDIQQEEPMETSHNISMEEECPIKKETNPDVVQETISNADDPNIELVDQKDVVSGEKQSEPKCQEQPQPKLTSPTVEPKASKGKARKKNSPLPKKVKFSDKVSFKDNDSEEKSNEEKSDEEPQKKADSAKPVKQISSFFAPRKPAIKTEKREENLNEKNVTETSLEESPKPKKNVGSFFGASKQEATEEQTEYNPSKSKYHPIDDACWCNGQKVPYLAVARTFERIEEESARLKNVETLSNFLRSVIALTPEDLLPCIYLCLNRLGPAYEGLELGIGETILMKAVAQATGRQLEKIKAEAQEKGDLGLVAESSRSNQRTMFTPPKLMASGVFGKLKDIARMTGNASMNKKIDIIKGLFVACRHSEARYIARSLGGKLRIGLAEQSVLSSIAQAVCLTPPGRDAPPTVMDAGKGMSADARKSWIEEKAMILKQTFCELPNYDAIIPILLEHGIDDLPKHCRLTPGIPLKPMLAHPTKGIGEVLKRFDEAAFTCEYKYDGERAQIHILENGEVHVYSRNQENNTTKYPDIISRIPKIKKESVKSCILDTEAVAGDAEKKQIQPFQVLTTRKRKDVDASEIKVQVCVYAFDMLYLNGESLVKEPFAKRRQLLRDSFLETEGQFMFATYMDKSNTDEISEFLDQSIKDSCEGLMVKTLEQDATYEIAKRSHNWLKLKKDYLEGVGDTLDLVVIGAYLGKGKRTGIYGGFLLASYDEESEEYQTICKIGTGFTDDDLEKHYNFLKDHVIENPRSYYRWDSATEPDHWFDPVQVWEVKCADLSISPVHKAALGLVEDQKGISLRFPRFLRIRDDKKPEESTNSFQVADLYRKQQQIQNTSSTEKAEEDFY", "function": "DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.", "AFDB_id": "AF-P51892-F1-model_v4" }, { "swissprot_id": "Q84R36", "sequence": "MAPSPAAAMPLAAEPDEVVVEVEEEEERGVKGGGGVAGLDEVEGLVVGSYCHDVLLRGGRVVGETLGGAAAFVSNVLDAASPAGASLAVVSKVGHDFAYATAAAPARHPPVLCASPTTSFHARFSDDAASAHAPDRQLRRVHACDPIYPADLPDRRFAYGLAVGVAGEVLPETLERMIRLCRAVLVDAQALIRAFDGEAKGGGAVRHVALEATPYARLLPRVAFLKASSEEAPYVGVETARRRCCVIVTEGRDGCRLYWDGGEARVAPFPAVQVDPTGAGDSFLAGFASGLLWGLSATDAALLGNFFGAAAVSQVGVPTFDPKMLQAVKQILEKAVKRPCTHINGNTFTFQRSSMHDELHKSLQEAAMLVCEQKQANSPATDNGDVCSINELTSLPS", "function": "Kinase that phosphorylates myo-inositol to produce multiple myo-inositol monophosphates. Participates in phytic acid biosynthesis in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.", "AFDB_id": "AF-Q84R36-F1-model_v4" }, { "swissprot_id": "B0Y568", "sequence": "MLDRSKMTSAIPDSNSSSSPRGHNQSERDSYNRKKRKGPRLAHRKSRTGCQRCRARRVKCDESRPVCRDCHRHGIPCVYDRPAEEGAIPPSTGIQSRPLEPSPSDPSNDAHMELRLLHHFTLFTSATMPGAHLKRIKDCWSIDVPRLAFSYKPLLHAVFAIAALHLSKVNPDEAGLPDIHCNFLEQALREHRLCIGGITTQTADAVCFTSILLQIDVFATLQSRHVVSYEQVSEWMRLVRGSVAVFDAAMEIVRHNTHPPNIWCIIDTFPMPLRTNSDAGSFSFLLPTVPDDEDDETALEAYRGAVAHINATWLAMEAKEHPQISCRRLMVFPLFVTAGFIDLLEKRRPRALVPCPHHYVTYGGSETLHTNTS", "function": "Zn(2)-C6 fungal-type transcription factor; part of the gene cluster that mediates the biosynthesis fumihopaside A, a hopane-type glucoside that enhances the thermotolerance and UV resistance of N.fumigata.", "AFDB_id": "AF-B0Y568-F1-model_v4" }, { "swissprot_id": "Q8VZ10", "sequence": "MALKLTSPPSVFSQSRRLSSSSLIPIRSKSTFTGFRSRTGVYLSKTTALQSSTKLSVAAESPAATIATDDWGKVSAVLFDMDGVLCNSEDLSRRAAVDVFTEMGVEVTVDDFVPFMGTGEAKFLGGVASVKEVKGFDPDAAKERFFEIYLDKYAKPESGIGFPGALELVTECKNKGLKVAVASSADRIKVDANLKAAGLSLTMFDAIVSADAFENLKPAPDIFLAAAKILGVPTSECVVIEDALAGVQAAQAANMRCIAVKTTLSEAILKDAGPSMIRDDIGNISINDILTGGSDSTRNSTAMLEENTVSDKTSANGFQGSRRDILRYGSLGIALSCVYFAATNWKAMQYASPKALWNALVGAKSPSFTQNQGEGRVQQFVDYIADLESKQTATTVPEFPSKLDWLNTAPLQFRRDLKGKVVILDFWTYCCINCMHVLPDLEFLEKKYKDMPFTVVGVHSAKFDNEKDLDAIRNAVLRYDISHPVVNDGDMYMWRELGINSWPTFAVVSPNGKVIAQIAGEGHRKDLDDVVAAALTYYGGKNVLDSTPLPTRLEKDNDPRLATSPLKFPGKLAIDTLNNRLFISDSNHNRIIVTDLEGNFIVQIGSSGEEGFQDGSFEDAAFNRPQGLAYNAKKNLLYVADTENHALREIDFVNERVQTLAGNGTKGSDYQGGRKGTKQLLNSPWDVCFEPVNEKVYIAMAGQHQIWEYSVLDGITRVFSGNGYERNLNGSTPQTTSFAQPSGISLGPDLKEAYIADSESSSIRALDLQTGGSRLLAGGDPYFSENLFKFGDNDGVGAEVLLQHPLGVLCANDGQIYLTDSYNHKIKKLDPVTKRVVTLAGTGKAGFKDGKVKGAQLSEPAGLAITENGRLFVADTNNSLIRYIDLNKGEDSEILTLELKGVQPPTPKAKSLKRLRKRASADTKIVKVDSVTSREGDLNLKISLPDGYHFSKEARSKFVVDVEPENAVAIDPTEGTLSPEGSTMLHFIQSSTSASVGKISCKVYYCKEDEVCLYQSVQFEVPFKVESELSASPTITFTVTPRAPDAGGLQLQGTR", "function": "Required to maintain light harvesting efficiency, especially during nonphotochemical quenching (NPQ) recovery, via the regulation of chlorophyll excited-state lifetime probably by preventing the formation of a slowly reversible form of antenna quenching.", "AFDB_id": "AF-Q8VZ10-F1-model_v4" }, { "swissprot_id": "I3R637", "sequence": "MASKKEQWKSDLYGDAVRDELEAFAEEGFESIPEDERDKWFTRFKFWGVFQQRTGQESYFMMRLTNANGVLEPGQLRTIAEVARDYATGPVDNPEFGNGWVDLTTRQSIQLHWLELEDIPEIWEQLESVGVTSRSAGGDTMRNITGCPVAGKDTHELVESKPLLDRFQSELREDDALSNMPRKFNISVTGCREGCAQDSINDIGLEPARKEVDGEVITGFNVRVGGGLGSRKPRVARSLDVFVADEERAYEVVRGFVELYHDHGNRDVRARARSRFFVDDWGTEKIRDRLESEYLDFELQSAGEDIRDEYTYNAGRPQSAGKSDHVGVHEQSDGRYYVGLSVAVGRLTAADALELADLADKYGSGKIRLTRRQNPIVMDVPAGALDDLLAEPLLSKHTPEPNPFQRGTVACTGTEFCSLALTETKARTARMLRWLRDNVEVPDDVHQLKIHYSGCTADCGQANTADIGLFGMRAQKDGEMVEAMDIGVGGGIGDEPSFVEWIHQRVPADEVPGAIASLVEAFAAHRTAGQTFRQWVEAEGPDAVAEYCEPIETDFEAPYMHDAKQSWYPFADEDEPPKTEQPMTSD", "function": "Catalyzes the reduction of nitrite to ammonium in the nitrate assimilation pathway, using ferredoxin as the electron donor. Can use reduced methyl viologen but neither NADPH nor NADH as electron donors.", "AFDB_id": "AF-I3R637-F1-model_v4" }, { "swissprot_id": "Q6NE74", "sequence": "MAETILIETKTAGGNCRSYLMAGASYLGILCFVPLLMSRDDEYVYFHAKQGLVLWMWSILAMFALHLPGIGKWLFGFSSMGVLMLSVVGLVSVALRRTWRLPLISHVVALI", "function": "Plays a role in regulating magnetite crystal size; partially redundant function with MmsF.", "AFDB_id": "AF-Q6NE74-F1-model_v4" }, { "swissprot_id": "Q9BQI5", "sequence": "MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQPSPHEPPYNSKAECAREGGKKVSKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMESPKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFGPVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPGPTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPPPTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRGKFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN", "function": "May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.", "AFDB_id": "AF-Q9BQI5-F1-model_v4" }, { "swissprot_id": "O58758", "sequence": "MRYAMNKIPALLLVGALIIATVASGCIGGTTTTETPTVTKTKTQEVITLKVIGPWSGAELDAFMEVLKAFEKQHPNIKIEYKTYRAEDLSTILPLQFESHDTPADVIFMWGWFIAEMGKKGHLMELNNIINPEEYVPGILDSVTVDGKIYGAPFTAAAKPGFWYRKSFFEKHNLKPPKTWDDFVALLEEIKKIPGIKAPIVSGDSVGWPLSDVTEHFILTFGGKDLQLKLIKGEVKWEDPQVRKIFEEKLVPLLKAGYFSDPIEWTSAVDLWWKGEYALYFMGTWITGMVDDPNDLGLIPLPGVKAMVIAPDYLMVPKYTSHPKEALELAKFLATEGQRIHVGTKSGKLATWKKVSIDDYWAPMRDVAKIVANVESAPDLDDSVGGEWQKVFWDQLKLLWVQPDRLDEVLKTLDEKFPKK", "function": "Probably part of a binding-protein-dependent transport system PH1036/38/39.", "AFDB_id": "AF-O58758-F1-model_v4" }, { "swissprot_id": "S0DTP6", "sequence": "MASHMKLYLFGDQTFDVQPHLQHLLQKRDNLFLHEFLNQSYNALRAELFKIPYSIRKDLPRFTCQEDLLLWDQSGPRCVALDMAMTTLYQLGTFISQAGISSYDAQNSRVVGLCTGAFAAAAVSCSSFTADLIPMAVSSVVAAFRTGLLVTDTARRVDPSQDLNRSWALLVPGQKAAKAFQEFWDANDGGVLTSMPYISAYAPNGITVSGPPQRLGDLAHWLASKSITSKAIPIYSAYHAPHLYSQKDARRIVDGLMLNKAVSPSEQIPLLSSTGSKPEERSFATLLEDAIAQALLHPLRWGSIFDDVQAALETTGSQQFSVQSIGSNAEHLIYTALKKTSLRYLVPETTVPSQPTSVPSVPDAGTSKPKLAIVAMSGRFPGAKDNEAYWDLLYKGLDVHKPVPSLRWDQQTHVDPTGAGKNTSATPFGCWLDDPSEFDARFFNISPREAPQIDPAQRLALMTAYEAIEQAGIVPDATPSTRPDRVGIFYGVTSNDWMETNSAQNIDTYYIPGGNRAFIPGRINYFFKFSGPSYAVDTACSSSLAGIHLACNALWQGDVDTAIAGGTNVLTNPDYHAGLDRGHFLSRTGNCKTFDDGADGYCRGEGVATIIIKRLDDAIAENDPILGVVLGAHTNHSAESESITRPHVGAQRVIFNKILNEAAVDPYSVSYVEMHGTGTQAGDATEMSSVLETFAPPVAEGKVARPESQKLYIGSAKANIGHGEAASGVCSVIKVLQMLKKDTIVPHCGIKNKINHRFPTDLEQRNVRIAMGPTQWKKGTEINPRRVFVNNFSAAGGNSALLIQDAPPRKQLIASNDSRIQFPIAITAKSGVSLQGNMRSMLKFLSTNSHVSLAELSYTTTARRIHHQHRVLIPGATSEEICSKIETALQNNTGVTRPKAAPKVVFTFTGQGAQYPGMGKQLFEENEFVRNELLSLDRIAQNLGFPSMLPFIQSDEPDVSKFAPSLVQLASVCLQITLSKLWASWGITPTAVVGHSLGEYAALNVAGVLSDTDTLFLVGGRAQLLEQKCTRGTHAMLVVKGSQEEITEALKGQEYETACINSPIETVLAGPNEQIAKVKEQLAAASFKTTLLKVPYAFHSSQLEPMVSDIEKLAGKVTFSDPKIPILCPLEGTVIENANPFNASYLARHSRQPVNMLTALTTAYRDGYLSDRSMVLEVGPHPAVSGMVKPTLGQQITCVASLQRRRAPWDMLSAALKSLYDAGASINWVDYQSNFPGAHTVVDLPAYSWDLKEYWIQYVNDWSLRKGDPPLVINNVSKLESTTIHSVVEESGDSEKTGIVVEADIARKDLSPLVQGHEVDGIPLCTPSVYADIALTLGKYLLERYQPQQKDDMVVVSDMTVSKALILRGDGSRHPIQAHAEADWSSQSVSIKFMSFDNKGNLQEHSACVVLFKDRSHQDALQSEALTTKQKMQNLRNQITTGESARFNRPMAYRMIRPLARFHDDYRAIDEVVLNSETLEASSKISFGTVKRDGDFHTHPAVIDALTQSCGFAMNCNDHTDIDVDVYMNHGWGSLELFEPLDFEKEYTTYTQMHAGEDKLWYGDVTIFDQDRVVAFFGQIAIQGVPRRVLKVILSIESGKKGQPQRQTQDKPRNTPSQTKDSTPKPAQNKPAAKVEPPKFSTAIRIISEESGIDVSDFTDGTTFADVGIDSLLGLTISARFQEELDIDLDFNALFFEHPTVKDLRAFLGADEDVSESSSSAASDSGRDTTTTGSATPELQEEFAESAEVEFERALEIISEESGVARSDLDDETNFADCGVDSLLSLVIASRFQDTFGLNIAHEQLFMECQTVGDLKTMLAREMGLATPASKPAAIPAPVVSEAVAQETVVTHSDTSNLAEREQAITELVNKYTAGFKAPTSNPNGPPLGKNESVVLVTGASGGLGSHLVYALAQLEEVHTVVCLNRPNREDPTTRQYKAMRDKGIRFPEHLKSKVRIFQTDTSKPKLGVADSEYASLIRSVTHIIHNAWPMSAKRPLSGFESQFQVFRNLLDLGRECASNRPADFKFSFQMISSIGVVGQWGLAAGQTGKIVVPEERTTIDSLLGNGYAEAKWGCERMLDETLHKFTDRFRPMVVRLGQIAGSKTSGYWNPMEHFGFLIKSSQTLNALPDVDGNLNWTPVNDIADTLTDLILSDRTPYPIYHIDNPIGQQWRDVNNILSDTLRIPNKVPFKEWLDMVRKAPQQDNPAALLADFLEDTYLRMACGGLVLDVKHSLEHSKSLSAVGPVSETVVRKYIHIWKEIGFLKTTAEDKAGFEAERLRLWGPRV", "function": "Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusarubins, highly pigmented naphthoquinones responsible for the coloration of the fruiting bodies. The non-reducing polyketide synthase FSR1 is responsible for the condensation of seven acetyl-CoA units to yield a haptaketide. After rings A and B are formed by aldol-type cyclization, the PKS-derived product is released as 6-O-demethylfusarubinaldehyde. Then, two hydroxyl groups at C-5 and C-10 are incorporated by FSR3, and simultaneously hydroxyl groups at C-6 and C-8 are methylated by FSR2. The aldehyde is, on the one hand, reduced by FSR3 to 8-O-methylfusarubin alcohol, which equilibrates mainly with 8-O-methylfusarubin and only small amounts of 8-O-methylnectriafurone. On the other hand, the aldehyde can be oxidized to form 8-O-methylfusarubinic acid, a reaction driven by FSR3 equilibrating with 8-O-methylfusarubinlactone, finally resulting in 8-O-methylanhydrofusarubinlactol after a further reduction step and loss of water. 8-O-Methylfusarubinic acid can also undergo decarboxylation, resulting in 8-O-methyl-13-hydroxynorjavanicin after another hydroxylation step at C-13. Both steps are most likely also accomplished by FSR3. No enzymatic function has been determined so far for either FSR4 and FSR5. Their deletion does not alter the product spectrum, but the possibility that they catalyze specific enzymatic steps during perithecium development cannot be ruled out. FSR4 might possess a regulatory function in the biosynthesis of fusarubins.", "AFDB_id": "AF-S0DTP6-F1-model_v4" }, { "swissprot_id": "Q2QXZ2", "sequence": "MSSEDSLKSLSLDYLNLLINGQAFSDVAFSVEGRLVHAHRCVLAARSLFFRKLFCGLDPNHQPPPPPPPPLNWPTAGGGGGGSGGGGRGGAGGGGGAPATPELVIPVSSIRYEVLVLVLQFLYSGQASVAAPKSGPLPGCGARGCWHTRCGAAVDLALDTLAAARSFGVEQLALLVQKQLESMVKEASVDDVMKVLMASRKFEMQELWATCSHLVARSGLSADLLAKHLPIDVVAKIEEIRAKSPLAAAAAPRSPFLTHHYLPMNPASSAADRDNKIRRMRRALDAADIELVKLMVMGEGLDLDDALAVHYAVQHCNRDVVKALLELGAADVNSRAGPTGKTALHLAAEMVSPDMVSVLLDHHADPNSRTLDGVTPLDVLRSLTSEFLFKGAVPGLTHIEPNKLRLCLELVQSAVMVTTRDDGAPVTGGEAGGSDGGNFPRSDADDSLVSLTMNSTLMYQGQEMAAAVAAGEGRKSNNGRGSPPPAMYFPNGFA", "function": "Involved in defense response against pathogens.", "AFDB_id": "AF-Q2QXZ2-F1-model_v4" }, { "swissprot_id": "P28721", "sequence": "MFFKKNLTTAAICAALSVAAFSAMATDSTDTELTIIGEYTPGACTPVVTGGGIVDYGKHHNSALNPTGKSNKLVQLGRKNSTLNITCTAPTLIAVTSKDNRQSTIVALNDTSYIEKAYDTLVDMKGTKNAFGLGSAPNGQKIGAASIGIDRSNGGIHAADDTGEIPVDLIQTDHWSAATPTWKASSNGAFCSLTSCSAIERGYSVAKTGELTPVAITAVTFPLLIDAAVNDNTILGSDETIKLDGNVTISVQYL", "function": "Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon.", "AFDB_id": "AF-P28721-F1-model_v4" }, { "swissprot_id": "Q7BHL7", "sequence": "MDKETNDNEYRRQSEHRTSAPKRKKKKKIRKLPIILLIVVILLIALVVYIVHSYNSGVEYAKKHAKDVKVHQFNGPVKNDGKISILVLGADKAQGGQSRTDSIMVVQYDFINKKMKMMSVMRDIYADIPGYGKHKINSAYALGGPELLRKTLDKNLGINPEYYAVVDFTGFEKMIDELMPEGVPINVEKDMSKNIGVSLKKGNHRLNGKELLGYARFRHDPEGDFGRVRRQQQVMQTLKKEMVNFRTVVKLPKVAGILRGYVNTNIPDSGIFQTGLSFGIRGEKDVKSLTVPIKNSYEDVNTNTDGSALQINKNTNKQAIKDFLDED", "function": "Involved in SarA attenuation. Affects resistance to oxacillin and teicoplanin, as well as the synthesis of virulence factors.", "AFDB_id": "AF-Q7BHL7-F1-model_v4" }, { "swissprot_id": "Q1QZP3", "sequence": "MPAVSRPLPPLTALAPPELEWRADDISDAPYASAYGDVYFSRHDGRAETGHVFVEGNRLPERFAAWRETRAFVIGETGFGTGLNMLCAWACFERHAPAEARLHLVSTEKYPLPRDALARALAIWPDMAARAGVLLDQWPEPVGGVHRLWLSSRVVLDLHFGDAAERLSRLDGRVDAWFLDGFSPAKNPDMWQPELFAAMAQVSRPGATFATFTCAGVVKRGLRDAGFTWRKTPGFGRKREMLCGEIAAPPDDRRRASTPWFTPPRARPARHVVVIGAGLAGTSVAAALARRGVAVTLLERDAPGAGASGNRQGALYVKLAAETNPQSRVYLAGLLYTRRWLTALDPEQRLWQDCGVLQLAPGDKEATRQQRFLAHHALPERVLHGVDAATASQAAGTPLDAPGLDYPQAGWVRPDRLCQQLAASPGITQRRGEAHDLDFDADADAWRIALTDGSTLTADHVVVATAHEAPRFTPLAGLPLKPIRGQLTHVPVPADAPSLARVVCAGGYVAPAMEGVLSLGATFAPGDTDTAVRTTDHARNLDEFTATLPAFAEALRAAGVTLDPAACEGRASLRAASPDKSPYAGPVPVREAWLDDYAVLGADARRVPSTAGRHHPGLWVSAAHGSRGLASAPLCAEVIASRLCDEPLPLERELIDHLHPGRRLIADIIRGNATRGNATLSTSSPNDDAQPSPTTTETP", "function": "Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.", "AFDB_id": "AF-Q1QZP3-F1-model_v4" }, { "swissprot_id": "P0CQ29", "sequence": "MYGDLALQLVNSSHRTTLSSTPQLPLPKYALPLILSICLETRQLGTSIASIAESHGQLSLTQDRGLVCNLTVQHLAARRNKRCMLAYLATRVGGIKERWWDAGGGLAYLLSPAASASVNPEADAPDLRSALSPQELDFLRGYNNLLLDYKSDFLDVLDLTAGIEKPPGEIMVDVRVVRDAGEVFLDSGERVDFRKGQRFRLERAQVERLIIQGYLEEV", "function": "The GINS complex plays an essential role in the initiation of DNA replication.", "AFDB_id": "AF-P0CQ29-F1-model_v4" }, { "swissprot_id": "Q05086", "sequence": "MEKLHQCYWKSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML", "function": "(Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses.", "AFDB_id": "AF-Q05086-F1-model_v4" }, { "swissprot_id": "O48684", "sequence": "MSSRFSLTVVCLIALLPFVVGIRLIPARITSVGDGGGGGGNNGFSKLGPFMEAPEYRNGKECVSSSVNRENFVSSSSSSNDPSLVHIAMTLDSEYLRGSIAAVHSVLRHASCPENVFFHFIAAEFDSASPRVLSQLVRSTFPSLNFKVYIFREDTVINLISSSIRLALENPLNYARNYLGDILDRSVERVIYLDSDVITVDDITKLWNTVLTGSRVIGAPEYCHANFTQYFTSGFWSDPALPGLISGQKPCYFNTGVMVMDLVRWREGNYREKLEQWMQLQKKMRIYDLGSLPPFLLVFAGNVEAIDHRWNQHGLGGDNIRGSCRSLHPGPVSLLHWSGKGKPWVRLDEKRPCPLDHLWEPYDLYKHKIERAKDQSLLGFASLSELTDDSSFL", "function": "May be involved in pectin and/or xylans biosynthesis in cell walls.", "AFDB_id": "AF-O48684-F1-model_v4" }, { "swissprot_id": "Q9GPS6", "sequence": "MVLILDNDLKPLYFTLAIISASFLVKRAYQSTNIYDFFNIKKKCNPFPQSQSELVDLLHYQKRMVLNKTIVETLKFVDRKLFLENKNVENPYYDEPKPIGYNATISAPHMHALMLDLLADRIPMSNGVALDIGSGSGYVTACLGHLMGCTGRVIGVEHIPELIERSIESIKRLDSTLLDRIQFLVGDGIKGWKQLKYDIIYLGAAIESLQVARELIDQLKNGGRIVMPVGKSNDFHELMVVDKNEDGIVSIKSLGVVRFVPLTSKENQLNPKNKPNATKVTNINGEKTLIRCEIIPAPDSNSNNNIKEFENLINKK", "function": "Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.", "AFDB_id": "AF-Q9GPS6-F1-model_v4" }, { "swissprot_id": "Q6R327", "sequence": "MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQMHEEAEAVLATPPKQPIVDTSAES", "function": "Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.", "AFDB_id": "AF-Q6R327-F1-model_v4" }, { "swissprot_id": "Q61179", "sequence": "MASGKVRCTRKLRSWIVEQVESGHFPGVCWDDAAKTMFRIPWKHAGKQDFREDQDAAIFKAWALFKEKHKDGDIGHPAVWKTRLRCALNKSSEFEEVPERGRMDVAEPYKVYRILPAGTLPNQPRNQKSPCKRSISCVSPEREENMENGRTNGVVNHSDSGSNIGGGGNGSNRSDSNSNCNSELEEGAGTTEATIREDPVFLEHQLPLNSDYSLLLTFIYGGRVVGKTQVHSLDCRLVAERSDSESSMEQVEFPKPDPLEPTQHLLNQLDRGVLVASNSRGLFVQRLCPIPISWNAPEAPPGPGPHLLPSNKCVELFKTTYFCRDLAQYFQGQGPPPKFQATLHFWEESPGSSHSQENLITVQMEQAFARHLLEKIPEEEKAALFLLQHTEQSPSALGH", "function": "Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.", "AFDB_id": "AF-Q61179-F1-model_v4" }, { "swissprot_id": "Q9ZT48", "sequence": "MSLKNDASSSHDGGSNRESVIDDHGRRKSTCGYCKSPARSSISHGLSAQTLTVYDYQALIDRGWRRSGTYLYKHEMDKTCCPPYTIRLKASDFVPTKEQQRVSRRLERFLDGKLDVQPREQRGASSSGDVSDTRRKTLGAAKSEENKKVEAVMDDLSKNIDQAVQLCIRSGEFPSNMQIPKASVKKVFCARRKKLAEGTEQILYTSNIAFPIAAAIKRIQTSEKEGINSAEGNRLSPETISEMLLSAMHKVGETPDVSIKVCKGHINFLSSAKDSFSDRDVVPNGNISRGANSLDGSETLHAKKDSENHQARKRKLEIHLKRSSFDPEEHELYKRYQLKVHNDKPGHVVESSYRRFLVDSPLIDVQPSGDEKVPPCGFGSFHQQYRIDGRLIAVGVVDILPKCLSSVYLFWDPDYAFLSLGKYSAIQEINWVIENQARCPSLQYYYLGYYIHSCSKMRYKAAYRPSELLCPLRFQWVPFEVARPMLDKKPYVILSDIAISHNQCSLLAGASETLVEPAASEHEDMEQGETNDNFMGCSDEDEDEDEDDDDDDDDDEEMYETESEDSHIESDPGSKDNDINNILIGLYGSQYRYKEMRQIITPVGRKQLEPMLQSYRKVVGAELSERMVYEIN", "function": "Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Component of the N-end rule pathway with ATE2 and PRT6. The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination. The end-rule pathway regulates various aspects of leaf and shoot development. Involved in the oxygen-dependent N-arginylation of RAP2-12, an activator of hypoxic gene expression. This N-terminal modification leads to ubiquitination by PRT6 and subsequent degradation of RAP2-12 under aerobic conditions. Has an important role in the progression of leaf senescence. Involved in disease resistance. The end-rule pathway plays a role in regulating the timing and amplitude of the immune response following infection with the bacterial pathogen Pseudomonas syringae pv tomato. Regulates the biosynthesis of plant-defense metabolites such as glucosinolates, and the biosynthesis and response to the phytohormone jasmonate (JA), which plays a key role in plant immunity.", "AFDB_id": "AF-Q9ZT48-F1-model_v4" }, { "swissprot_id": "Q8RCN8", "sequence": "MEELKALILSIQFMTGIPIPINIDVKEDKIYKIASYFPVVGLLIGGILYIAYLLLKDLFSREIVMTFLVAFSYILTRGMHIDGLADTFDGLFSNKDREKIIEIMKDSRLGTNGVLALVFMVILKILFLSDIRQSLLFSALLVSPVIARLSVVFSIAISKSARGGKGLGGLLLERAGLREFVIALLISTIAGYFVMPLKDLALLYVISLSFTCLISKYISKKIGGMTGDTLGAVNEFVELIAFIYFSIL", "function": "Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.", "AFDB_id": "AF-Q8RCN8-F1-model_v4" }, { "swissprot_id": "Q9I6P6", "sequence": "MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLHYDGSPRDVRRLCADLGLEILLFQPFRDFEGCRRERLGRNLERAERKFDLMQELGTDLVLVCSNVAADALGEPALLADDLRQLAERAAVRGLRIGYEALAWGRQVNTWEQAWDLVRRADQANLGLILDSFHTLSLDGDPRGIADLPGEKIFFVQMADAPLLAMDVLEWSRHFRCFPGQGGFDLAGFLAPVVASGYRGPLSLEVFNDGFRAAPTRANAVDGLRSLLYLEEKTREHLQRQTPHVAVDELFAPPPASLCDGIEFLEFAVDETLGARLGQWLQRLGFARAGEHRSKNVSLLRQGDINLVLNAEPYSFAHGFFEAHGPSLCATALCVRDAGQALERARAYGGQPYRGLLGPNEREIPAVRALDGSLLYLVERHTEGRSIYDSDFVTNDADTSGLGLRRVDHVALALPAEGLDSWVLFYKSLFDFGADDEVVLPDPYGLVTSRAVRSPCGSVRLPLNISEDRNTAIARSLSSYRGSGVHHIAFDCADIFAAVAQAKEAGVALLEIPLNYYDDLAARFDFDDEFLSELAYYNVLYDRDAQGGELFHVFTEPFEERFFFEILQRRHGYAGYGAANVPVRLAAMAQARRGVRRVKL", "function": "Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. Is required for growth on either quinate or shikimate as a sole carbon source.", "AFDB_id": "AF-Q9I6P6-F1-model_v4" }, { "swissprot_id": "Q4P3D8", "sequence": "MTSIRTSNCASEGRRLTILYMTQTGTSSDLALRISRQAQRKRFHVTIADVCSYDPTDLVSESLMLFLVSTTGQGEFPTTSRPFWNFLLRKGIPEDILEDVTFAAFGLGDSTYPRFCWPVRLLSRRLRGLGAKELVEHGEGDDMHYLGLEGELGPWMNRFWRKLDELCPLEAGVREVGRDELLPPSVTVTKVETEEGRLKEKHDGRDALGRHLEDQGWSISILDKNQRMTATDHFQDVRLLEFVRLNQTDVEEDKRQIGENEEISRGSASALDGISIQTYRPGDILCLHPINDAASVTEMLSRLDLDADTLVSLAGSTIPSTVPQSPAHMSVRDLLTHHLDFTSVPTNSFFEQIRLFSPTGSQEREKLDEYCGIFPEEELAKGANPQDGIDEMYEYAQRPRRTIKEVLDEFKSVQVPLAYIADVLPWIKPREFSIASAPPANSEREKRVSEEPHAIQLSVAMVKYKTRLRKARTGLCTRWLSSLPLGSRVPVVIKPGYLTLPPAQAPLILIGPGTGCAPLRSLVIDRLSNSTLARSEIHLFLGFRYRTKDYLFQHDWQHLQQSYANQFHLHTAFSRDGEAKTYVQDLIVKPDNAHVLWEAITERNAWIVVAGASGKMPEQVRGAFESIARSQGGMDEEQAKRFMDALERQRRWQEECWG", "function": "NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.", "AFDB_id": "AF-Q4P3D8-F1-model_v4" }, { "swissprot_id": "Q8FNZ0", "sequence": "MLNVTDLRGHTPSKSDIRRALPRGGTDVVSVLPIVEPVVDDVQNRGAEAALDYGEKFDHIRPASVRVPAEVLKAAEDTLDPRVREAIEESIRRVRKVHADQKPREHTTELAPGGTVTERFLPIDRVGLYVPGGNAVYPSSVIMNAVPAQEAGVGTLVVASPPQADHGGWPHPTILAACSILGVDEVWAVGGAQAVALLAFGDDSADLEPVDIITGPGNIFVTAAKRLVRGVVGTDSEAGPTEIAILADDTANPVNVAYDLISQAEHDVMAASVLITDSEQLARDVNREIEARYAITRNADRVAEALRGKQSGIVLVDDIEVGIAVADQYAAEHLEVHTANAREVSERISNAGAIFVGDFSPVPLGDYSAGSNHVLPTSGTARFSAGLSTHTFLRPVNLIEYDEAALKDISEVVINFADAEDLPAHGEAIRARFETLPTTTADTTDTPDATA", "function": "Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.", "AFDB_id": "AF-Q8FNZ0-F1-model_v4" }, { "swissprot_id": "A0RUR7", "sequence": "MGQLGVGRTGKTAVLDIELRRSGSRTIISRQYSEVPLQVQRALYPDAGLPGMAHVYVLSPSGGLLQGDRYKTSISLKDKAAAHVTTQGASRIYGMNSNCAIHKMDISAGKGCYLEYIPDQVIPYAKSRYFQEVRLAIDDDAAAVYSEVVTPGRVAMGESFLYDILCTSVRCENQDGSLRFAENARAEPRRMNLRGEAVLGGYSVHGTVYVMAPPESARTIEYTAGRIISHTDGILGGTSLLPGGAGITARLLSHRTDSIFKCIEGIAGACRMEMTGAAYPGIRKC", "function": "Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.", "AFDB_id": "AF-A0RUR7-F1-model_v4" }, { "swissprot_id": "P0CT89", "sequence": "MPSPLRQLLELMIQAVETLESVCEEKGISLPDLHAPYTPASEAFLRIPAAIEAANVITAAADHMSAIVSPPTSYLYKFLGGPCRAVAIRACLESNVSEIIREAGPSGIHVDDIAKKNGHDAQKLARFLRYLATHHIYREVSPDVFTHSRLSCFFDTYKPSAEVIANPKQKYDNTRGFAAPASHHLDITFKAAALAWETMDDPKTGHSDELTDAPFARAFPEDKTLWNLLERDAFARNRFDLTMVAVAQRQSPDSIFRAFDWERLPAGALVVEVGGGMGTSAFPLATKYPEMRLVVQDLPDVIAKAEKLWTEKMPDALSSGRVVLQGHDCFAPQPQTDAAVFLLKMILHDWSDEYCVKILRQLRAAARPDTALVIVDCLVPLACRLDDAAEAALPGAVGPQAPPPLLPNYGTVNEYVYNMDVMMHLLFNAQERTVAQFTRVLLRAGWRVCAVHRTQEGNGVFLQSVEAVPA", "function": "S-adenosyl-L-methionine-dependent methyltransferase that preferentially catalyzes the methylation of 4-OH phenolic compounds like coniferyl alcohol, vanillyl alcohol and ferrulic acid. May play a role in promoting lignin degradation by methylating and inactivating free-hydroxyl phenolic compounds, products of lignin cleavage which are known inhibitors of lignin peroxidases.", "AFDB_id": "AF-P0CT89-F1-model_v4" }, { "swissprot_id": "Q06201", "sequence": "MSDTTEVPRQSSENDQDNNLERTNSLKSPDVTNNIPSLFKLAAEWQINNPQETFQNHILENDVLKKINEITHLIRESYKDLSSQDGMMSKQQQEKMDWDLFCTVPVNIIEQYTKDMDEIYEKMERLAKQQRLWCESAFQIDVERCGDSILNAETWMKKKERHLEYKNIEMERSANEIKETIQRLTDDR", "function": "Probable transcriptional activator involved in meiotic prophase and synaptonemal complex (SC) assembly.", "AFDB_id": "AF-Q06201-F1-model_v4" }, { "swissprot_id": "P54787", "sequence": "MTDDEKREILKEFDPFSQLEQANGNPDKDVKFKKDDPNRAAAEETNRDISAQDKGDEEPFYDFQIFIKQLQTPGADPLVKYTKSFLRNFLAQRLLWTVSEEIKLISDFKTFIYDKFTLYEPFRSLDNSKMRNAKEGMEKLIMGKLYSRCFSPSLYEILQKPLDDEHMKDLTNDDTLLEKIRHYRFISPIMLDIPDTMPNARLNKFVHLASKELGKINRFKSPRDKMVCVLNASKVIFGLLKHTKLEQNGADSFIPVLIYCILKGQVRYLVSNVNYIERFRSPDFIRGEEEYYLSSLQAALNFIMNLTERSLTIEDHEDFEEAYQRNFKQLAEEKEEEEKKKQLEIPDELQPNGTLLKPLDEVTNIVISKFNELFSPIGEPTQEEALKSEQSNKEEDVSSLIKKIEENERKDTLNTLQNMFPDMDPSLIEDVCIAKKSRIGPCVDALLSLSE", "function": "Required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. May bind a Rab GTPase such as VPS21.", "AFDB_id": "AF-P54787-F1-model_v4" }, { "swissprot_id": "Q9M2U1", "sequence": "MVFSSLPVNQFDSQNWQQQGNQHQLECVTTDQNPNNYLRQLSSPPTSQVAGSSQARVNSMVERARIAKVPLPEAALNCPRCDSTNTKFCYFNNYSLTQPRHFCKTCRRYWTRGGSLRNVPVGGGFRRNKRSKSRSKSTVVVSTDNTTSTSSLTSRPSYSNPSKFHSYGQIPEFNSNLPILPPLQSLGDYNSSNTGLDFGGTQISNMISGMSSSGGILDAWRIPPSQQAQQFPFLINTTGLVQSSNALYPLLEGGVSATQTRNVKAEENDQDRGRDGDGVNNLSRNFLGNININSGRNEEYTSWGGNSSWTGFTSNNSTGHLSF", "function": "Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence. Enhances the DNA binding of OBF transcription factors to OCS elements.", "AFDB_id": "AF-Q9M2U1-F1-model_v4" }, { "swissprot_id": "B9FXT3", "sequence": "MPRRARARGGGGGGGEEVKVEDDFIDSVLNFGGGGGGEEDGDDGEEEQQQQQAAAAAMGKEFKSKNLEAERRRRGRLNGNIFALRAVVPKITKMSKEATLSDAIEHIKNLQNEVLELQRQLGDSPGEAWEKQCSASCSESFVPTENAHYQGQVELISLGSCKYNLKIFWTKRAGLFTKVLEALCSYKVQVLSLNTISFYGYAESFFTIEVKGEQDVVMVELRSLLSSIVEVPSI", "function": "Transcription factor that plays a crucial role in tapetum development. Required for male fertility and pollen differentiation within the developing anther. Plays a major role in maintaining tapetum development, starting in early meiosis. Required for pollen mother cell meiosis. May regulate the anther-specific cysteine protease CP1 and lipid-transfer proteins C4 and C6. Required for anther development. Functions in parallel with GAMYB to regulate early anther development. Functions upstream of the transcription factor TDR and may positively regulate its transcription.", "AFDB_id": "AF-B9FXT3-F1-model_v4" }, { "swissprot_id": "Q6CC11", "sequence": "MYDPARDCYQAEGESADARDAAEIAGGEFLADSATPETKSDSTKSDGNDPKQETSETKRPAYNYLPKIARKETTSGSRDAASAKPQLKRREREDVRVAGDRVAPRADMGSYVDYSEKESRERQDRDRDSRDHRDRDRDRDRGRDRYDSRDRDRYDSRDRPRDYDSRDRDRDRDRDRYDDRVRDYDSRERDRYDDRARDYDRGSRDSRDYRDRHDRERERYDSGNSRETRDVRESRERSLSPTREPKPHDPAAPAPSKQKRPSQRGGREAAAARAAQYRAEMEKREARAQAAAQQGDQVGDSLVRNHYNQAPERGVVARQSSPIIKLRNFNNFIKSVLIQKQSLGFGMRVIDMGCGKGGDLNKWSRQRVRDYIGVDIADVSVQQASERYHNMQPRPRFYAEFHVADAFGTPLIDIINPRAFPVDCISSQFAMHYAFATEELARSMLTNVSNSLCRDGVFLGTIPNSDKILEGIAGGLKESEPKEGEERYGYFGNSVYKVEFNTPPTKDQAFRPPFGHKYTFYLQDAINNVPEYVVPFEVFRALASDYNLELIYKKPFLEMFDEEVKNDLNMARLAERMKVFKEDGSLGIDGDQREACGFYLAFAFRKLGA", "function": "Responsible for methylating the 5'-cap structure of mRNAs.", "AFDB_id": "AF-Q6CC11-F1-model_v4" }, { "swissprot_id": "Q02084", "sequence": "MANSTVAEPEKMEQSGTCEEDEEEENMEGDEDECDDDEEENMEPAETVTIGSTYKCRRSDNTLHAAEIIKTRKTKENAEEFYVHYVGLNRRQNEWVDKSRVLQAKQIKTEELNNTEDETNGVSDQSEGKAARSNKRKIEDGDGDQKKRKVDDEEDDFTEDLTCPLCRSLFKEPVILECGHNFCKHCIDKSWESASAFSCPECKEVLTERKYTTNRVLANLVKKAAVGVKDKDVKPKEKCDEHDERLKLFCKDDGTLACVICRDSLKHSNHNFLPIQDAVGVYRDQLIALVSPLETTMKENQKLKCDQSQKISLHRENIVDCKKHIECEFEKLHQFLREKEAKMVEDLNAEREGLLKDMEANLVKMTDNCEFIEEAISTTQSRLNESDPIAFLTDIKSFIEKCCEEHRKGVPAESVLVNKELSQGRFKGPLQYIIWKELKSVVQPGLAPLTLDPNTAHPNLVLSEGLTSVKYTDTKQQLPDNPKRFSQCILVLGAEGFDSGKHYWEVEVGNKTAWDVGMASESSNRKGKIKLNPKNGYWAIWLRNGNAFKALESPSKTLNLTSKPSKIGVYLDYEGGQVSFYNADDMSPIYTFNGSFTEKLYPYLSPFLQDSGKNAEPLKLVHTKL", "function": "May be a nuclear regulatory protein that is stored in the germinal vesicle for use during early embryogenesis and may play a role in the synthesis or processing of pre-mRNA during oogenesis. Binds 3 Zn(2+) ions.", "AFDB_id": "AF-Q02084-F1-model_v4" }, { "swissprot_id": "Q6FR30", "sequence": "MSRNVDKSQTVLALYQEHKAESRRDYNRYKRPRVESVRDPAEAREWYKQTLREVGECTNRLYDPLLSEEQVRECNARVNQLIQESQRWSRHLRRFKQRQRPPVYGGVVVNGVRYIGRARELPEARKRPTAARQFTVKRAKYVDFSDNGDFSDNGDYRGTSERLRKAHGIAQQESVLVEPPTQQQMEEYLVERRKRQLLHQLNL", "function": "Involved in pre-mRNA splicing.", "AFDB_id": "AF-Q6FR30-F1-model_v4" }, { "swissprot_id": "Q6E211", "sequence": "MHTKVLQQGLWALLLWPHLFTVSVPLDCRDDQASLARCPSISQEKLLDRVIHHAELIYRVSEESCSLFEEMFIPLPLRLQSNQGGYACITKALPIPSSKSEIQQLSDKWLLHSVLMLVQSWIEPLVYLQMTLDRYDHAPDMLLNKTKWVSEKLISLEQGVVVLIKKMLDEGAMTTTYSEQGAFQYDVQLEMLEYVMRDYTLLTCLKKDAHKMETFLKLLKCRQTDKYNCA", "function": "Selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells.", "AFDB_id": "AF-Q6E211-F1-model_v4" }, { "swissprot_id": "Q97UL6", "sequence": "MIKVSAPGKILWIGSYSVVFGGISHVIAVNKRVSCSLREIKEKDSLIFHTSYGHFKNSGNELINSVLDTFRERLSQLPQGYEIDLYNDKEFIIDGKKTGLGSSSAATVSLTACLYYAIHGKLDLFEIHKLAQIANYKRQKGIGSGFDIASAVFGSIVYKRFTDLDKMDFYFEKLNLGNYDMMLGFTGKSSETVGLVRKFVEKSNLDDFKEIMRLIDEENYMAIKLIKLNKLDEAVEHIKLGRKYLNYIAERIVGVKLVSKMEEELIKIAEEEGALVALSPGAGGGDSIFALGNDLNRVREAWSKRGIFIIDVKEDEGLRLESN", "function": "Catalyzes the phosphorylation of (R)-mevalonate 5-phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.", "AFDB_id": "AF-Q97UL6-F1-model_v4" }, { "swissprot_id": "Q8N8U9", "sequence": "MLWFSGVGALAERYCRRSPGITCCVLLLLNCSGVPMSLASSFLTGSVAKCENEGEVLQIPFITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCEQCKGCTYEGNTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHLGMCCPTCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQEGCCEECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKILNRKGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPFQVLVKNDARRTRSFSWTKSVELVLGESRVSLQQHLTVRWNGSRIALPCRAPHFHIDLDGYLLKVTTKAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSWEFQTCHSTVDYATFYRSCVTDMCECPVHKNCYCESFLAYTRACQREGIKVHWEPQQNCAATQCKHGAVYDTCGPGCIKTCDNWNEIGPCNKPCVAGCHCPANLVLHKGRCIKPVLCPQR", "function": "Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.", "AFDB_id": "AF-Q8N8U9-F1-model_v4" }, { "swissprot_id": "Q7V1W1", "sequence": "MKEKLTVSDSKKLFHEQFPYVIPGLYKRIVDEMLVELNLLNHQNEFIQDDLFCVGLTETFKELTKGYKPEEHLRVLFESLCNSSNFEPKKIKEASKKTLEVYKDKSLKEISILLKQKSDSNLYSSRILNLGIYLIIANATDFKDIKDPEKNKIISDIINKLNLSFNKAEKDIGIYKSSILKMEQAKELLQEAKIKDKKEKKK", "function": "May be involved in photosynthetic membrane biogenesis.", "AFDB_id": "AF-Q7V1W1-F1-model_v4" }, { "swissprot_id": "O02604", "sequence": "MEDLSDVFDIYAICACCKVAPTSEGTKNEPFSPRTFRGLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTSVSEVYNSKGTTLDFLVYSKVGGGVDGGASNGSTATALRRTAMRSTAMRRNVAPRTAAPPMGPHSRANGERAPPRARARRTTPRQRKTTSCTSALTTKWGRKTRSTCKILKFTTASRLMQHPEYQYLGIIYDIIMNGNKQGDRTGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMAA", "function": "Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.", "AFDB_id": "AF-O02604-F1-model_v4" }, { "swissprot_id": "B1HUK4", "sequence": "MGRQGLIHIVILQYKLGGIYPMKAVDIRQMYLEFFKEKGHHHEPSAPLVPINDPSLLWINSGVATLKPYFDGRVIPDNPRITNAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKKEAIHYAWEFLTDKKWMGFDPELLSITIHPEDQEAYDVWHQEIGIPEERLIRLEGNFWDIGEGPSGPNSEIFYDRGVEYGSDENDPEMYPGGENERYLEIWNLVFSQFNHNPDGTYTPLPKQNIDTGMGLERIVSVVQNVPTNFDTDLFMPIIEKIEEFANRKYKRPSEVDLNEIFGSEEDINTPFKVIADHIRTVAFAIGDGALPSNEGRGYVLRRLLRRAVRYAKQIGIEKPFMFELVPTVGKIMEDFYPEVTEKCEFIQRVIKNEEIRFHETLDGGLAIFNEVAESQKAAGHDFIPGADAFRLYDTYGFPIELTEEYAEEVGMKVDHEGFETAMEEQRERARAARQDVDSMQVQNEVLANLTVASEFVGFDTLVANTEIAAMIVNGQVEKVASEGQEALVILAKTPFYAEMGGQIADSGIISNDSFTAVVKDVQKAPNGQPLHTVIVESGEMHVEDAVQAIVHRDDRNLIIKNHTATHIMQRALKDVLGDHVNQAGSYVGPDRLRFDFSHFGQVTKEELQQIERIVNEKVWDDIEVVIEEMAIDQAKAKGAMALFGEKYGDVVRVVSIGDYSIELCGGIHVKRSSEIGFFKIVSEGGIGAGTRRIEAVTGKVAYEVVKEEEALLNDAAALLKANPKDIVTKVQALQGDYKELQRDNEALSQKIANAHSWGNCRCSTNNWRCHSSFYKSRSKDNNLLRQMMDDLKALMPKAVIVLGAVDGDLSDAMCRGITIINRWQLPCWKYREIWCQKLVVVIGGVRPDMAMAGAKDASKLDEALLSVYDYVKSI", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.", "AFDB_id": "AF-B1HUK4-F1-model_v4" }, { "swissprot_id": "Q2NF84", "sequence": "MSVGADKIISNIKADAQAKADEIISKAKAESEKIIADGEAKAQIEKEQILDSANKQADMKYQQIISEAKVNSRRKELEAREELIEKAFRIASEKIEKLASENSANYVESLKVMIKDASIQVGSTQLEILVREDDVENVKSMIDEVSEYVTKETGNETSFVIGEPIDIIGGAVVKTVDGDVEVKNTIEARMLRYRKHLRSEVAKKLFR", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-Q2NF84-F1-model_v4" }, { "swissprot_id": "Q9HVZ6", "sequence": "MSRLFVKRLPTGSFLMLLLYIGLLLSAIAVAYSTYWNRQLLNSLYSELSVRDKAQAEWGRLILEQSTWTAHSRIESLAVEQLRMRVPDPAEVRMVAP", "function": "Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.", "AFDB_id": "AF-Q9HVZ6-F1-model_v4" }, { "swissprot_id": "A0A084AFG8", "sequence": "MATATPPPQDFPPYPPFTSLRLAAARDVAQMANLSVQGFKDSEIFRYERPGHDQYPEDAVAYFANLYRDRLEDPRAVVIVAEDWDGAERVVVGVGCWILPQDSPRTGQFVVPCVGDREPALDRDLCCRRLELFNAVTKATEERYLDGKVICDKFVVHPSYQRRGHGTAMLRWSLRLCTQDTVDQGVIPSHVGEPVYLSLGFEVIGEMHVPDEGDTQGFTQRVAVYKARQT", "function": "Acetyltransferase; part of the satratoxin SC3 cluster involved in the biosynthesis of satratoxins, trichothecene mycotoxins that are associated with human food poisonings. Satratoxins are suggested to be made by products of multiple gene clusters (SC1, SC2 and SC3) that encode 21 proteins in all, including polyketide synthases, acetyltransferases, and other enzymes expected to modify the trichothecene skeleton. SC1 encodes 10 proteins, SAT1 to SAT10. The largest are SAT8, which encodes a putative polyketide synthase (PKS) with a conventional non-reducing architecture, and SAT10, a putative protein containing four ankyrin repeats and thus may be involved in protein scaffolding. The putative short-chain reductase SAT3 may assist the PKS in some capacity. SAT6 contains a secretory lipase domain and acts probably as a trichothecene esterase. SAT5 encodes a putative acetyltransferase, and so, with SAT6, may affect endogenous protection from toxicity. The probable transcription factor SAT9 may regulate the expression of the SC1 cluster. SC2 encodes proteins SAT11 to SAT16, the largest of which encodes the putative reducing PKS SAT13. SAT11 is a cytochrome P450 monooxygenase, while SAT14 and SAT16 are probable acetyltransferases. The SC2 cluster may be regulated by the transcription factor SAT15. SC3 is a small cluster that encodes 5 proteins, SAT17 to SAT21. SAT21 is a putative MFS-type transporter which may have a role in exporting secondary metabolites. The four other proteins putatively encoded in SC3 include the taurine hydroxylase-like protein SAT17, the O-methyltransferase SAT18, the acetyltransferase SAT19, and the Cys6-type zinc finger SAT20, the latter being probably involved in regulation of SC3 expression.", "AFDB_id": "AF-A0A084AFG8-F1-model_v4" }, { "swissprot_id": "P80668", "sequence": "MTEPHVAVLSQVQQFLDRQHGLYIDGRPGPAQSEKRLAIFDPATGQEIASTADANEADVDNAVMSAWRAFVSRRWAGRLPAERERILLRFADLVEQHSEELAQLETLEQGKSIAISRAFEVGCTLNWMRYTAGLTTKIAGKTLDLSIPLPQGARYQAWTRKEPVGVVAGIVPWNFPLMIGMWKVMPALAAGCSIVIKPSETTPLTMLRVAELASEAGIPDGVFNVVTGSGAVCGAALTSHPHVAKISFTGSTATGKGIARTAADHLTRVTLELGGKNPAIVLKDADPQWVIEGLMTGSFLNQGQVCAASSRIYIEAPLFDTLVSGFEQAVKSLQVGPGMSPVAQINPLVSRAHCDKVCSFLDDAQAQQAELIRGSNGPAGEGYYVAPTLVVNPDAKLRLTREEVFGPVVNLVRVADGEEALQLANDTEYGLTASVWTQNLSQALEYSDRLQAGTVWVNSHTLIDANLPFGGMKQSGTGRDFGPDWLDGWCETKSVCVRY", "function": "Acts almost equally well on phenylacetaldehyde, 4-hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde.", "AFDB_id": "AF-P80668-F1-model_v4" }, { "swissprot_id": "Q96PZ2", "sequence": "MSCKKQRSRKHSVNEKCNMKIEHYFSPVSKEQQNNCSTSLMRMESRGDPRATTNTQAQRFHSPKKNPEDQTMPQNRTIYVTLKVNHRRNQDMKLKLTHSENSSLYMALNTLQAVRKEIETHQGQEMLVRGTEGIKEYINLGMPLSCFPEGGQVVITFSQSKSKQKEDNHIFGRQDKASTECVKFYIHAIGIGKCKRRIVKCGKLHKKGRKLCVYAFKGETIKDALCKDGRFLSFLENDDWKLIENNDTILESTQPVDELEGRYFQVEVEKRMVPSAAASQNPESEKRNTCVLREQIVAQYPSLKRESEKIIENFKKKMKVKNGETLFELHRTTFGKVTKNSSSIKVVKLLVRLSDSVGYLFWDSATTGYATCFVFKGLFILTCRHVIDSIVGDGIEPSKWATIIGQCVRVTFGYEELKDKETNYFFVEPWFEIHNEELDYAVLKLKENGQQVPMELYNGITPVPLSGLIHIIGHPYGEKKQIDACAVIPQGQRAKKCQERVQSKKAESPEYVHMYTQRSFQKIVHNPDVITYDTEFFFGASGSPVFDSKGSLVAMHAAGFAYTYQNETRSIIEFGSTMESILLDIKQRHKPWYEEVFVNQQDVEMMSDEDL", "function": "(Microbial infection) May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction.", "AFDB_id": "AF-Q96PZ2-F1-model_v4" }, { "swissprot_id": "P38636", "sequence": "MAEIKHYQFNVVMTCSGCSGAVNKVLTKLEPDVSKIDISLEKQLVDVYTTLPYDFILEKIKKTGKEVRSGKQL", "function": "Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.", "AFDB_id": "AF-P38636-F1-model_v4" }, { "swissprot_id": "O94611", "sequence": "MTESERTSHLDILYENQRGIMLCGVPYFSEKSLLNFDPAPWVDQHFVASPVSTKTATCPDPSWEWAWQRWYIDMSGDVDESGWQYGFSFTMNNWHGKPVSLHSFVRRRRWIRKRKKKELRRDELPLVPESFTISSSYPIQRSSTQTRSSFEDDSSDFDLSEVTTIPALLRALQDSRIDREKLEALATFLASASIDEKVYVKNCKKDLLKNFVFEHSCRKANELLNASLTAAEASTSQVALRESPTPQD", "function": "Has a role in meiosis.", "AFDB_id": "AF-O94611-F1-model_v4" }, { "swissprot_id": "Q8XT73", "sequence": "MSLNVLFVASEAVPLAKTGGLGDMVGACAGALQRAGLHVTVMLPGYPAAQAQLRDARVACALPDLPGGPARVLLGAMPDTGVPVLLLDAPALFDRPGNPYLDACGEPYADNALRFAAFSHAAAHVAGGVPDLPAFDIVQAHDWHAALVPLLVKRAGRPVKTVLTVHNLAFQGNFPPRIAQDLGLPPEAVREAGFFGQFSFLKAGLMWADRITTVSRTYAREILTDAFGYGMQDVLRARRHDLVAILNGIDNAVWNPSKDAYLSRPFFAGNLSGKHAAKLQLQTLLRLPKDAHAPLLALGSRLTHQKMADVALQALPQMLEAHPDLQVAVLGCGERRYESAMAALAERHPRRMAAVIGYTERNAHMLHAGADLLLHGSRFEPCGLTPLYAMRYGTVPVASRVGGLVDTIADRGSPEAALRGATGFLFDGETPEAMAGAVARALRVFVQPRAWRVLQYNGMTTDFGWSQPASEYLALYATLAPRATPMPHLQHWPMRTLARPASPPDTAPVGKPARRRRTTALSTTARAHPVARAAGREKIRA", "function": "Synthesizes alpha-1,4-glucan chains using ADP-glucose.", "AFDB_id": "AF-Q8XT73-F1-model_v4" }, { "swissprot_id": "Q6L732", "sequence": "MALAAPPGELTLALTPDDKTLDPASLDRALAILAEHGILVLTGMLRTRLTDQLRTAMLDDLPEVLRQQDVPTNFVPGHVQQDPPVRESLLFPDVLLNPVVYQITHAVLGADARNAVYSGNMNLPGSHEQPVHLDEPHLWPGISHPPYCLCVDVPLIDFTLENGSTEYWPGSHVLNPDECYDERGCVLPAELERRRAVAPPVRFPIPVGSVVIRDGRLWHRGVPNLSAAPRPLLAMTHYTEWFDMPPIQLPDTVKSWVDGSDRHTHAHFVAGDVDHLTGDHPFAVR", "function": "Mediates the conversion of kanamycin B into 2'-dehydrokanamycin A during the transformation of kanamycin B to kanamycin A.", "AFDB_id": "AF-Q6L732-F1-model_v4" }, { "swissprot_id": "A0A0P0ZEA9", "sequence": "MEGSINDARRTNYLVLLRTCYEIYGIYEPLLALFAVYSVAVVVYRLYLHPLARFPGPKLAAATGWYEFYHDVFRGGQYLYEIESMHRKYGPIIRINPHELVVNDPDFYNTVFVAANTRRTDKWSGLEGIGLRGSLAFTRDHDLHRIRRKRYEPFFSRLSVSRIEPIIVDEAKLLAKQLEASSKTGRVIELEHVMSAFTGDVITTLCSEKSPDMIRHPEFGKGWHTSLYNFPSCFRAGAFNSFLEYSTDHINTAKREMLSVDKLEQNNKSSVFRYVLSTDMPQAERDTERLAREAALLFGAGSVTTTRFFSVTIYYTLRNRQIRDRLSAELKDVMAGYPSTLPTWQELDRLPYLHAIVKEGLRYACPFVLSSSLAAWSSLSHKFSSRLSYGVMRHLSRISPDSALHYKQWTIPPGTPVGMSSYSLHTDPETFPEPFKFMPERWLGEYNPKMNRSWVPFTRGSRNCLGMNLAYAQIYWGLAVMFRPGGPRLELYETNESDIRPVLDFLGPLPKSGSRGLRVTVS", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the sesterterpene stellatic acid. The first step in the pathway is performed by the stellatatriene synthase that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylgeranyl diphosphate (GGDP) and then converting GGDP into stellata-2,6,19-triene. The cytochrome P450 monooxygenase Stl-P450 then catalyzes three successive oxidation reactions on the C-20 methyl group to generate the carboxylic acid of stellatic acid.", "AFDB_id": "AF-A0A0P0ZEA9-F1-model_v4" }, { "swissprot_id": "Q52E66", "sequence": "MDPLEARQLIPAAPGSDDEGRTSRARLCQAVNLPANGALVMPNGEVITLTAPAAFKPACAPNTTPAIIAGPGGTTGAGVDDAAHVGPQFSDLSDPFYASTFPQCYALAATTVIAYTLVIMLVITPRSFLDGGIVVLGRRGFTSGGSGHGIIGGRPWLQKVAALTVAISLTIATADTFKVAEQQYAFGLQNARELQDKVLNGTELKIIRIISDTFLWLAQAQTLIRLFPRQREKVIIKWTAFALITFDLIFDSLNSFQFPGPGNSRPGSFTDAIPALSYLFQLALGVLYAAWVIYYSLMKKKYAYYHPQMKNICFVAGLSLLSILVPVVFFILDISKPEFTGWGDYVRWVGAAAASVIVWEWVERIEALEREEKRNGILGREVFDGDEMLETDSDATWPQRSRATKGPHGDGDDDDDDGEGGRRIAVGDGTGRRRARRANGSHDSLAADSGRGRNHTQLWTSIASRYRSRPNNGADVSETEKDNTRQTSKNVRPAAARFLQPPLWPARPPPAATPVSRTDTASADSTVYAIRYHPLTDVHSRTTTRPTPPPQLSTERQSAVVDVSGTPTAVEDVRSHDQPSGSQSASPSPPRDQQSPGPPNLVRLSREETRRERRQSLATTSRTGTRVGPDSDDPSASSQQGGESSRGSESTAAKGWRTLAQTLPFRGGTARSAEDSSDSQSTTSKSRSKLQVSREGKSDRWDLRNRMEDFAVTQAERIRERIRPTPDTDSLPVTVIPAPARRGAALAQLLEEDESRQGSGRPRPQDDERPILGSPTLPSSGQRQNSMGPEPLSSNDDLSDSHIPPPAVVRAASRANTSRSTTRDRPPEP", "function": "Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.", "AFDB_id": "AF-Q52E66-F1-model_v4" }, { "swissprot_id": "Q8KLS9", "sequence": "MIDLPRHPPSMLPVIRTVPEHAATGELKRRYDAVKSAFDVPWMGVVAMAHTQYPRFFDALWEGFEPIAGTRAFQDACRAMRAATEAGVERSLGISPLAHRLQDLGYDPREIGEIRTIIEVFSHGNYPYILLATVSRYLLSGGDLSGEPQVFETSPRSPHIFHQPILMEPHHADEHTRGIFADIQATLALPILNTDYRALARWPSYFHLAWAELRPLIRTPSHAALSQQLHEQAIAVLRTLPNPARLKGDMVTRGCGR", "function": "Catalyzes the hydrolytic dehalogenation of small (R)-2-haloalkanoic acids to yield the corresponding (S)-2-hydroxyalkanoic acids. Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-2.", "AFDB_id": "AF-Q8KLS9-F1-model_v4" }, { "swissprot_id": "B8G8K0", "sequence": "MPVHMMMSGIIIAGGRSRRFGTDKRRLRLWGEQGPCLLERAVALLQPLCSEVLVVLNDAHAWPDLPARLVADEQPGSGALGGVISGLQAMQTPTALVIAADMPVIVPALLAALAQWPFVGDALIPSSYPHPGQLQPLLAVYRHSALAPLRRVFAAGERRLQVAVTALHWVDPGPELWQMYDPTARSLLNLNTPDDLKLVQAYLGTTNI", "function": "Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.", "AFDB_id": "AF-B8G8K0-F1-model_v4" }, { "swissprot_id": "B8MPW2", "sequence": "MAAAALIRSTRCNTCRRYLLQSFTRVVGLTAQNSRLPNEPQRRQFFTTPYLNIKSSHRHLSDRDASAASNNEYFITNESANSSQAVPWYLQVEPVIEPTHPAVRQQEIPAVPANAPPITQEILQHLSLEIGLDDMVLLDLRGRDPPPALGGNVIMVIGTARSLKHLNVSADRFCRWLRSTYKLRPYADGLLGRNELKIKLRRKARRARLASSSGTISDTSDDGITTGWICVNVGSVDDPSVVQNMREGGFEGFGKVQGGTRIVVQMFTEDKRADVDLEQLWAPKDNVKAGDSEENHSYSTGGDYQVRSMPPITSENNSNHPISNVPRPLRRVDLSQRRSFSTGAGQHSARTDVDPESGYEVVDAKNESSRQEPPLSAIFSTLKEMSPEETIEQLGSGPEDKNSTEFLRDCYSSVGTSHNGNSALRLMLGAAGVSAQHPGYTKEYLWTLFLEQTASGYRISEPLGFEIASAFLVPRRLDAKEQGRTASEFVDFDIESAMRVMDNLSLNGETIIRKHRVYNMMYEALILGLRNERLDDVRLKALRIRTLMTEIGLDWQSEDTRETMQLRLLLGDVDGFYEIWHAIAFNEGSRTADDYELLFRVHAEAGNPVYARECLGVWISMMGREDPPVLPSASIISAIARCAHVAGHDADTFRLLSASDEWREVERLILSDLRTLEQLT", "function": "Probable mitochondrial mRNA stabilization factor.", "AFDB_id": "AF-B8MPW2-F1-model_v4" }, { "swissprot_id": "Q96ME1", "sequence": "MASSGEDISNDDDDMHPAAAGMADGVHLLGFSDEILLHILSHVPSTDLILNVRRTCRKLAALCLDKSLIHTVLLQKDYQASEDKVRQLVKEIGREIQQLSMAGCYWLPGSTVEHVARCRSLVKVNLSGCHLTSLRLSKMLSALQHLRSLAIDVSPGFDASQLSSECKATLSRVRELKQTLFTPSYGVVPCCTSLEKLLLYFEILDRTREGAILSGQLMVGQSNVPHYQNLRVFYARLAPGYINQEVVRLYLAVLSDRTPQNLHAFLISVPGSFAESGATKNLLDSMARNVVLDALQLPKSWLNGSSLLQHMKFNNPFYFSFSRCTLSGGHLIQQVINGGKDLRSLASLNLSGCVHCLSPDSLLRKAEDDIDSSILETLVASCCNLRHLNLSAAHHHSSEGLGRHLCQLLARLRHLRSLSLPVCSVADSAPRADRAPAQPAMHAVPRGFGKKVRVGVQSCPSPFSGQACPQPSSVFWSLLKNLPFLEHLELIGSNFSSAMPRNEPAIRNSLPPCSRAQSVGDSEVAAIGQLAFLRHLTLAQLPSVLTGSGLVNIGLQCQQLRSLSLANLGMMGKVVYMPALSDMLKHCKRLRDLRLEQPYFSANAQFFQALSQCPSLQRLCLVSRSGTLQPDAVLAFMARCLQVVMCHLFTGESLATCKSLQQSLLRRWGEVTGRRPQLFTELREEPSARTSRATGRRQPCLPDSGVVCCPCGRPLAVSGIILVGVSPSLVVKTTCVYRVLFKNLDYASIFFLVCLFETESHSVVQAGVQWRDLSSLQPLLSGLQPQPPEQLENELEIGFSYCFVI", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", "AFDB_id": "AF-Q96ME1-F1-model_v4" }, { "swissprot_id": "Q21624", "sequence": "MAQIVRQSKFRHVFCKPVKHESCMSDIRVTEITWDSLFCDVNPKFIAFINRGAGGPFMVIPVNKIGRVDKDYPFVDAHKAPCLEVAWSPFNDNVIASCSEDTTCKVWVIPDRGLNRNLSEPAVELTGHQKRVNTIAWHPVANNVLLTAGGENVMFMWNVGTGEALLEISGHPDQIWSINFNFDGSQFVTTCKDKKIRILDSHTGEVVHEGMGHEGVKPQRAIFVKDGLILSTGFTKRSERLYALRAPEDLSTPIVEEELDTSNGVVFPFYDEDSGLVYLVGKGDCAIRYYEVNNDAPYVHYINTYTTNEPQRAVGFQSKRGMSSEENEINRIYKLTTKGVVDILQFFVPRKSDLFQHDLYPDTRSTIPALTAEEFMEGKNAAPNRQPVNAAAAAAAAKPKVQVAKKANILSTLAPTAAESVPTQSYSERPPSSQQPSPRPSASPRPRPVVDDDMGIVTMREAPPSRPASSRASRTEIPPKEESKVDPMKPKQAVQLKSRAARDEPGGGAQTAGQRRAAAELERIKRDQSRTADEDNTLAPPPSSSRASASPRGSVSAASDVGHVPQNMDELLEDLMKMKAVLRQHERRIRMLEEEIADRNMSNAYSF", "function": "Required to direct the migration of Q neuroblasts along the anterior axis of the body during larval development. This is dependent on its asymmetric expression in Q neuroblasts.", "AFDB_id": "AF-Q21624-F1-model_v4" }, { "swissprot_id": "P29064", "sequence": "MRSIKAASLTPLLAALFTTLSSTLALPSSVWEHQLETNVLALRDTNNNGSSSTISPSFDVTKCPGYKLVGQPQQSQHGFTAQLSLAGDACNAYGVDIANLTLSVVYEKQHQLHVHIYDTAKQQYQLPNGLIFDRPGDNPADIQNGSTADQSDLVFHHTAENGTQSGNGGWAFWIARKSSGDVIFDTRASNIPTYNDGLSSVSSNTKRNTTAMPAHEMVFENQYLQISSALPTGANIYGLGEYVTGSFRRNPDETLQPFFTLDAGTPVDSNMYGYHPIYTEARRGSDGKLRTHSVHLQNTAGMDVLLRRGVIQYRAIGGTLDFRFFSGDQPASSSSSSSGNDKAVATVKNSPNTAIQQYVNFIGNPVIHPYWSYGFHLCRWGYNNVSETQAVIDAMRQNNIPLEVQWNDIDYLQEFRDFTTDPQRFPQKEFAAMIAKLKDNHQHYIPIIDMAIPKAPTNDTDVYYPGTRGDELDVFIKNRNGSQYIGEVWPGYTNFVDQQAENAGKWWTEAIRNFSEIVDFSGIWLDMNEPSSFVIGNAAGPETNLSNTPAYTAATSVAGWPQGYNNLTWGTSGNITVNGSYTYQQGPVQNNDGSKQRRSLLLSRDEDVLVQRDINVNGGNGDKFGPEDPNYQYANSSQRYLSNPPYAIHNGIHISETPLNVNLDKKTVAMEAVGVDGQRAFYDVHNLDGTLEEQHFYNALRDIRPQERPFLISRSTYPGAGKFTGHWLGDNYALWTILPGEEAYKAGAGMAQSIDGVLQFQIFGIHLIGADICGFNRNSDEELCNRWMMLGAFLPFMRNHNTIGAIAQEPFRWDSVANASRIAINKRYEILPSLYSHMAQSAESGEPAVRALWYEFDEVFEQTKDYAHQFLFGDDLLVSPVLEPNVTQIKALFPNAGGKWRNVFSYEALDVEYNKNVTVDAALSTINVHLRPGKVLLTHSKPAYTVYETAQSPYGLIVNLNDQGEAKQTFYLDDGMTPAPTPNSTLTVSAGNNSVNGSIEGEYKAQQNLTYVVVLDVKQKPTQVMMGGNKTEFSWDQQKTLLNVTGLNADLNGSGRFRGLRLELSLLCED", "function": "Hydrolyzes a broad range of alpha-D-linked glucopyranosides, including maltose (alpha-1,4), sucrose (alpha-1,2), isomaltose (alpha-1,6) and turanose (alpha-1,3).", "AFDB_id": "AF-P29064-F1-model_v4" }, { "swissprot_id": "Q2L4W6", "sequence": "MNGIITPQKQKQLMSSPSRDPLSTTELSTPTSQTTVDVNDTKKSEGLDSTIILLTPGTSPNATPGSSELGLSKKPNSIKNNTYSTAAQAAYLNRRAADQSTVMTTDPISYANNNINNGTLPQQNAYYANSYYPSYYAQSQAISNNRPGVSGFRPAFNSVAPCYGSQWQTHQSVHPYHVNNTHQYLKPYVQNVYPQMPSLNQPGLHIVNQPTYLAPVPSATVPTNSVSLSMPSFSQGQKNIPAAINQEMSVGTTKENTNYLSQLVGLHPAIPPAIPSMFPMSHDNKKSNMESTSRTRNVYIRGLPPNTSDENLLLYTNRFGKVSSSKAIIDMETNLCKGYGFACFEEEKSALICISAMTLCGYQCSFAKESFSARLQSLQDTESTNLYISNLPLHWNESDISTLFKPSKIISNRVLRDSKEQSRGVGFARMQDRKTAEDIINKFNNFVLDPALPPLQIRFADSTDQKKFKGQTQKRRLWRAREYSVLTKGMTANNAFSKVEEFANNSMPSKVGMYVPLESNTVYQHSPTYDTYGWQSMYPSYSVYPSNYENSRSTTPYHAHPATSAAN", "function": "RNA-binding protein which plays a role in sporulation. Regulates the progression of meiosis I and may function in the vicinity of the Mei2 dot.", "AFDB_id": "AF-Q2L4W6-F1-model_v4" }, { "swissprot_id": "P38877", "sequence": "MPSVDIDASQWQKLTQSREKQTTVITPLGMMMLEIQGELELPKDFASLARRDSPNEGRFSEQDGETLIRFGSLQIDGERATLFVGKKQRLLGKVTKLDVPMGIMHFNSKDNKVELVDVMKYKVIFKDRPLPIM", "function": "Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.", "AFDB_id": "AF-P38877-F1-model_v4" }, { "swissprot_id": "Q2V0W1", "sequence": "MGGEGGADDSVVHFVFVHGASHGAWCWYKLTTLLVAAGFKATSVDLTGAGINLTDSNTVFDFDHYNRPLFSLLSDLPSHHKIVLVGHSIGGGSVTEALCKFTDKISMVVYLAADMVQPGSTSSTHDSIMTVGEEDIWEYIYGEGADKPPTGVLMKEEFRRHYYYSQSPLEDVSLASKLLRPAPVRALGGADKLSPNPEAEKVPRVYIKTAKDNLFDPLRQDRLVEKWPPSQLYILEESDHSAFFSVPTTLFAYLLRAVSFLQL", "function": "Involved in chlorophyll degradation. Specific for the pheophorbides of the dihydroporphyrin and tetrahydroporphyrin types. Chlorophyllide a, pheophytin a and the nonfluorescent chlorophyll catabolite (NCC) are not used as substrates.", "AFDB_id": "AF-Q2V0W1-F1-model_v4" }, { "swissprot_id": "Q5EAR6", "sequence": "MRVDENLRLDEQLLLFMEQLEALEEKRQRLNSLIEEGWFSIAKARYSMGNKQVSALQYASEMQPLAHVETSLLEGGTAEFKCERSENKAEEQKTKTIEDIGAKETGLRRRVHTKQKEVKEGEQDTDEVKTKTDSPTPEHRNPLKWFGILVPQNLKQAQSAFKEVITLSVEIASLQSTILATRKEMQVQMKEKQERTEKAQLEVKEE", "function": "Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. May be involved in Golgi homeostasis.", "AFDB_id": "AF-Q5EAR6-F1-model_v4" }, { "swissprot_id": "Q2NHB7", "sequence": "MDILTLIFYSIYLMIPAYLANGSALVFGGGTPMDFGHYCWDNRRLIGNGVTWRGTVCGGLFGMVIGGILGLLATYGIGSYFFNITASQITFMSGFVPQGLLVGFLLGFGALIGDAIGSFLKRRLNFERGKPVPLLDQLDFVVVSLLFVSTVVSLSLEMIVIIILVSIFLHLGANMFAYMINLKDVWY", "function": "Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.", "AFDB_id": "AF-Q2NHB7-F1-model_v4" }, { "swissprot_id": "Q52986", "sequence": "MYVAVKGGEAAIANAHRLLADRRRGDRALPAITIDQVVEQLGLAVDRVMAEASLYDRALAALAVRQARGDMIEAIFILRAYRTTLPRFGYCEPVDTAKMKVERRVSATYKDLPGGQLLGPTFDYTHRLLDPSLIGEEPVDEPVLKEPGEHVMRVSDILDGEGLIEGDGKMPEGHVAGDLTREPMEFPMARDLRLQALARGDEGFLLALAYSTQRGYGRTHPFVGEVRIGEVEVELELPELGFAVSLGVIRVTECQMVNQFKGSSRQPPQFTRGYGLVFGQSERKAMSMSLVDRALRTDEFDEDIVAPAQDQEFVISHADNVQATGFVEHLKLPHYVDFQAELDLVRRMRREHDAAQAGGKDGMKEAAE", "function": "Together with PhnG, PhnH and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.", "AFDB_id": "AF-Q52986-F1-model_v4" }, { "swissprot_id": "Q9UTR5", "sequence": "MLRNGAQNGNINSESHESFGKAAKGFRIFSSFSSSQKLFQRRSSGSITHSPTALSSTTSLNENDGNHFRPASSLSFSPSSLSRKDSGPGDGLEVNKKNNFYRRSSSTDDFGISHARSRKEIQSLGRPHTRQSFSVSDVSNGSSYPNIRKNSVHVNAPMPSFPEGSTAVLLKHHSGSKSASAISNIAPSHSNSTSSRRPYIHPAFLSQVAVEFRKRLNIGDRVKDGLLYKDAFLGSEAVDVLMHIVRTTDRNLALLLGRALDSQKMFHDVTYSHRLRDSLKEVYQYRRIISPPPGLSSMDSNGSSIENNFLYTKRRANTSDSFDSVLSDSSTTPTISSSVQVNSLAFITSSLSAITKEPEAPETEYNPHGVFTLLTECYSSTCSRNRLCYSISCPRRLEQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNRQQFIRCVFHNIMQIHAVNSRLSNALNRTQTLQPVVNTIGDLFLDYVPKFEPFIKYGANQAIAKFEFEREKSTNRNFANYVHEVERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQLSCSPADRAKLTLFDPSRLLIFKGVVKLKASSYSNGDTENDIHMFLLDNFLLLCKIKIQMKRRVHKLHLRPLPLELLSISYIEDSPSRGSLPRRPSSALLTNPISITKSNPPPVKAYGLQLVFIGARGFSISLYLNTLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQSWFTGNKLLCAVAYDAGRKLLFGTYKGLYISSRKSNNGSCLEPIFKLQLPNISQLDVIEEHNVLLLLAEKILYELPLDALDSVEQINSKSLRRVTGHVSFVKTGFCMQRILVCAVKSTVLNTTLRIYEADRALKNKKTQSLKKPFGNQATLKIFTEVQMPMEALSVHFLKTKLCVGSFKGFDIISLENAVFQSLLNPADTSFRFLEKREDIRPIAMFRLRGEFLLCYSDFAFFVNTNGWKSRQSWMINWEGQPQGCALCYPYILAFEPDFIEIRNAETAELVQIIMGQNIKLLTDGRGLISEGGEILYSTEPIPFSSGENPIVHSLILPPANAAGPAL", "function": "Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches.", "AFDB_id": "AF-Q9UTR5-F1-model_v4" }, { "swissprot_id": "Q6MGS3", "sequence": "MYAIIRTGGKQYKVQAGDVVQVDKLEQALGAEFEINEVLMVGGESTAVGQPLVKGAKVTVVVTKQAKTRKEIVFKKKRRQGYRKFATHKQEFTELFVKAISFDGKTAKSDEAATVVDVKAVRAEKAQARVAARKERAANKGPAEVVKKAAKKVAKKKVAKKAVKKTVKKATKTGAKKKAAKKTSKKA", "function": "This protein binds to 23S rRNA in the presence of protein L20.", "AFDB_id": "AF-Q6MGS3-F1-model_v4" }, { "swissprot_id": "Q9UNY4", "sequence": "MEEVRCPEHGTFCFLKTGVRDGPNKGKSFYVCRADTCSFVRATDIPVSHCLLHEDFVVELQGLLLPQDKKEYRLFFRCIRSKAEGKRWCGSIPWQDPDSKEHSVSNKSQHASETFHHSSNWLRNPFKVLDKNQEPALWKQLIKGEGEEKKADKKQREKGDQLFDQKKEQKPEMMEKDLSSGLVPKKKQSVVQEKKQEEGAEIQCEAETGGTHKRDFSEIKSQQCQGNELTRPSASSQEKSSGKSQDVQRESEPLREKVTQLLPQNVHSHNSISKPQKGGPLNKEYTNWEAKETKAKDGPSIQATQKSLPQGHFQERPETHSVPAPGGPAAQAAPAAPGLSLGEGREAATSSDDEEEDDVVFVSSKPGSPLLFDSTLDLETKENLQFPDRSVQRKVSPASGVSKKVEPSDPVARRVYLTTQLKQKKSTLASVNIQALPDKGQKLIKQIQELEEVLSGLTLSPEQGTNEKSNSQVPQQSHFTKTTTGPPHLVPPQPLPRRGTQPVGSLELKSACQVTAGGSSQCYRGHTNQDHVHAVWKITSEAIGQLHRSLESCPGETVVAEDPAGLKVPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKKEEKEKSTALTWLSKDDSCDFTSHGTLIICPASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIPTNKQEAEIPGANLNVEGTSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSKKGGERLSILTKSLLLRRTKDQLDSTGRPLVILPQRKFQLHHLKLSEDEETVYNVFFARSRSALQSYLKRHESRGNQSGRSPNNPFSRVALEFGSEEPRHSEAADSPRSSTVHILSQLLRLRQCCCHLSLLKSALDPMELKGEGLVLSLEEQLSALTLSELRDSEPSSTVSLNGTFFKMELFEGMRESTKISSLLAELEAIQRNSASQKSVIVSQWTNMLKVVALHLKKHGLTYATIDGSVNPKQRMDLVEAFNHSRGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVIHRFVCEGTVEEKILQLQEKKKDLAKQVLSGSGESVTKLTLADLRVLFGI", "function": "DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.", "AFDB_id": "AF-Q9UNY4-F1-model_v4" }, { "swissprot_id": "O13800", "sequence": "MNQVTQFSGNSANLMLYWILKSYYSRFDRIMWIDTLGTFNPAALPLPCLEKTMLVRSFDAQGLKDAVDELESNLKSSEDQAYALCIDSFSNPIGLLMAQGNISFAHAFMMTLGRKCRILTRKFRLAVYLSTSLVYIKQLHLSKPALGNSWPFCLDHSYILEDQQHNKCLVHCNQSRKDLLGCSQLFLLLKGSFTHEYLTIDFYNGTPVSVSSKLHVSPSLYHSSTLNSPS", "function": "Involved in homologous recombination where it functions at an early stage of recombination in a pre-recombinogenic complex with rlp1 and sws1. Also has a role at a later stage of recombination in association with the rhp55-rhp57 complex.", "AFDB_id": "AF-O13800-F1-model_v4" }, { "swissprot_id": "Q21187", "sequence": "MCSTMTATMNQTICEKQNITMDLLRSPIQIPSASDTIKIETPSTISSQPSPIQTPLAAASSDNFERPSLSYKDLIIEAIDRSPEKRLKLNEIYQVIRLLHPYYRHRPDQWGWQNSIRHNLSLHDCFVKLPLKQTSASGVVGHFWTVVPELSDKQTLRRRNRQQPRALAKKSDAGRTLSRDDRGSSGSGETSPSPSQPSISPPNENPMPSVQALNVLELLSGMNDYKGTLFQNNYRTNLIQDNSAVNGLQNLLTTTLMQINPQLGALLSLANLNNLTTNQLQIASPSLSPIKAESQSFLLQ", "function": "Transcription factor. Binds to the regulatory elements of genes that contain the sequence motif 5'-TTGTTTCT-3'. Involved in regulating intestinal transcription of vitellogenin vit-2, acting in concert with transcription factors elt-2, mab-3 and daf-16, and also the TGF-beta/Sma/Mab pathway. Functions downstream of the insulin/IGF-1-like signaling (IIS) mediated pathway, in regeneration of axons after injury and in short-term memory, perhaps acting in neurons, and in modulation of longevity, perhaps acting non-neuronally. Plays a role in the modulation of endoplasmic reticulum (ER) homeostasis during chemical and pathogen stress, including exposure to the Gram-negative bacterium P.aeruginosa.", "AFDB_id": "AF-Q21187-F1-model_v4" }, { "swissprot_id": "Q55736", "sequence": "MDGLFAPIPSNPLIDFTILLLVTLILPPIFERLKLPGLVGLLFAGIVLGKSGLGVLNEDSESIKLFTDIGKIYLMFVAGLEIDMVDFRRTRNRSLLYGSLTFAVPLLTGLAVGLTFGYSFNASVLLGSLFASHTLLGYPIVQRLGIVRNQAVMVTIGATIFTDIAALLVLAICISIHSGSFSPAGLVVQLVAIAVYSALVLIGFDWAGREYFRRTGDEQSNQFLFVLLAVFLASVGSELINVDKIVGAFLAGLAVNDVLGNSPVKEKVEFLGTTLFIPFFFIGIGLLLDLPAFLVTLTTLFPLVVAIVVGLILSKGVAAILAQWKLGYTWVEGLTMWSLSIPQVAATLAAAVAGYQAVNAAGDRLVSETVLNTIIVLMLITSIVGPLMTAKFAPKIPIPNTLSSLTEDLDDPEENGAVTLIPPKASTFTVLVPTQNPQTLSYLLEMGALIARHESGVVIPLAIAKAPVHMDDPGLTSRLARNELLLQQATELATNLKVDAHPALRIDDDVARAISHTAREKNADLIIMGWSQQTLGLRAKLFGSTIDSVFWSAHCPVAVMRLLSDPRSFHRILFPIKNLTPQTLELFQFTQRLAETNGAIVTLLHVCPHNTSPQQVQAFKTEMERFLNQCRATADYPIKVICHDDAAKVLVRVSHTFDLVVLRSFRRRSVGGVALGEVTDKILREITSSFVLFGDPYA", "function": "Na(+)/H(+) antiporter.", "AFDB_id": "AF-Q55736-F1-model_v4" }, { "swissprot_id": "P46670", "sequence": "MDFTAKIKELERELSETSDYKTLQKKTISLRSELNTLSHSLTSYEKEHFSNDIENVLKSINAKLSESKGKKRLFSFKQKNSSSAVHKNVERTELANAPAYTTTLKKHYVLEKGDSAFENLEFCTVTSTTDYSGNSALSGSLCFRNITKCVINLQRIFFQTGSIFITDCTDSIIFLRSPSDKDFQIRLRDLKNCKILIEKLSPSIDCKQVVIIENCHKCIFNASTRDHLIIQDFSNPFQSEETEDNSAFAFEDFDICNKDTMQLFRAYL", "function": "Tubulin-folding protein; involved in the early step of the tubulin folding pathway.", "AFDB_id": "AF-P46670-F1-model_v4" }, { "swissprot_id": "Q08BB3", "sequence": "MARKTVSRKRKAEEPKEQQFDWCQSAFKRPRVSSSVRHAQHWWQSRRSVVCSVRGREFRPQQQHEWSFQRSLRGFAAGRIPGILREREFSLGRLNKVFASQWLNHRQVVCGTKCNTLFVVDVLSGQITRIPMLKDREGRGEVSQGLGGVGSPFHFHNPGSVGGLDVQQGCGIHAIELNPSRTLLATGGDNPNSLAVYRLPTLDPVCVGDDGHNDWIFSIAWISDTMAVSGSRDGSMGLWEISEDVLSQAEKRQNVEGVPGYSHISHRALKDIPKEYTHPYNCKVRALAFNNSHKELGAVSLDGYFHLWKAEDNLSKELSTKLPYCKENVCLAYGLDWSVYAVGSQAHVSFLDPRQSSQNIKSVSSRERGSGIRSVSFYEHIVTVGTGQGSLLFYDIRAQRFLDGPSSTPGGYRNRTAEGILKLTTGRGWLNHDETWRSYFSDIRSFPNAVYTHCYDDSGTKLFVAGGPLCSGLHGNYAGLWS", "function": "Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, leading to their ubiquitination and degradation.", "AFDB_id": "AF-Q08BB3-F1-model_v4" }, { "swissprot_id": "Q44287", "sequence": "MKMKAKWLPIAAGVTAALASQAAFAVDFHGYFRSGVGVSTDGSMQTGLSDNAKQKVGRLGNEADTYGEIQLGSEVFNKDGKTFYVDSMVAMTSNGSNDWESTESKFQCTSANGTALDGCENKEDATFALRQFNVQAKGLLGFAPEATLWAGKRYYQRHDVHISDFYYWNISGRGAGIEGIQAGPGKVSFAWVRNDRSGTNVDGTYNDEMNVNTLDLRYAGIPLWQDGSLEVGVDYAIANPSDAQKDSANAQYKNAKDGVMLTAELTQGILGGFNKTVLQYGTEGYSKTFAFWGDRSWYGAEAKDGADGFRIINHGVIPMGNSWEMGHQLVYGVGNDMWDTNDKWETMSVVARPMYKWDDFNKTIFEGGYFKDKNKSTNGTSEEDAGYKLTLAQAWSAGSSFWARPEIRVFASYLAQDKKEMKGNAFNNGTADDTWNFGVQAEAWW", "function": "Involved in the transport of maltose and maltodextrins.", "AFDB_id": "AF-Q44287-F1-model_v4" }, { "swissprot_id": "P53112", "sequence": "MSDVVSKDRKALFDSAVSFLKDESIKDAPLLKKIEFLKSKGLTEKEIEIAMKEPKKDGIVGDEVSKKIGSTENRASQDMYLYEAMPPTLPHRDWKDYFVMATATAGLLYGAYEVTRRYVIPNILPEAKSKLEGDKKEIDDQFSKIDTVLNAIEAEQAEFRKKESETLKELSDTIAELKQALVQTTRSREKIEDEFRIVKLEVVNMQNTIDKFVSDNDGMQELNNIQKEMESLKSLMNNRMESGNAQDNRLFSISPNGIPGIDTIPSASEILAKMGMQEESDKEKENGSDANKDDNAVPAWKKAREQTIDSNASIPEWQKNTAANEISVPDWQNGQVEDSIP", "function": "Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17.", "AFDB_id": "AF-P53112-F1-model_v4" }, { "swissprot_id": "A7Z9Y5", "sequence": "MGKQPIDLLMQPSWRIIDQSSLGPYFDAKQSFAMDDTLCASVGKGESPATARSWVHHRTIVLGIQDTRLPFLEDGVKLLEDEGYRVIVRNSGGLAVVLDEGVLNISLIFEDEKKGIDIDRGYEAMTELVRRMLRPHHAEIEAYEIKGSYCPGSYDLSIGGRKFAGISQRRLRGGTAVQIYLCADKSGSERADLIRRFYQAALKDKSNDTKGVYPDIRPETMASLSELLRTDITVQDLMLALLTELKELSGRLYAAGLSPEEEMVFEKNLTRMLERNEKVFGTQESLD", "function": "Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.", "AFDB_id": "AF-A7Z9Y5-F1-model_v4" }, { "swissprot_id": "A0A0A2IBP6", "sequence": "MESTDSSPPLSMTDTEKKGDAVTTVTDESSVSEYERFLHLENVFSGASRKKLLRKLDLRLLPTLSFLYLMCSLDKSNAGNAKLFGLLEDLGMSGTQYNLALMYFFFTYGLSEPVSNIMLRRVGPKIWFPFIVCAWGLITTLTSQASSYAGFVVIRLMLGITEAGLYPGAYFILSMWYTPKEIGTRMAIFYGANTTAGAFGGVIAYGVGSLDGNLGWRAWRWLFLIEGCITIFAGLACLFCLPAFPHQYQAGKGTKWLTDEELEYASLRVKYANGPVSSTYTFRWSDVVAAAKDRKTYFMMMLFWWGGSVPTYSLSYTLPTMVANLGYTAVKAQVMTTPPYIFATCVCVAVGYISDQTQRRYLCIMGAYTLGLIGIIILWITVHHPSIPGVSYFAIFLAAAGYSAQAPIVGAWTASNITNPSKRAAAIGLLMLLGSVGGGSIGSNIYISSEAPTYPLGFGFSVGATVLGAMIPATIHWFLMRKENKRRGGLDVAEIERKYTTEELGEMGEDSPLFRFVL", "function": "MFS-type transporter; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals. With the MFS transporter cnsL, is most likely responsible for cummunesins secretion and thereby may contribute to intrinsic resistance (Probable).", "AFDB_id": "AF-A0A0A2IBP6-F1-model_v4" }, { "swissprot_id": "Q5TYQ1", "sequence": "MIHLSQTMDKSSLPSLSDLCMSLVSSRLELFCEMRDDGSLSFREPLVFPQELADQLLCKMATDGVLNDSTVGIFRNCQQFRLRHACIRTARISAEAFHRALCPHRLVELDASRVNADLTIADILRGLSSNKSLQESLQRLVLNGLTMSSLEEPSRRCFSAMQGLRALSVSNVDFYDWGLADVCLLPRLESLDISNTSVSNLTPLLGLRSRLRYLTMHQLKRLEMTTAQLLAVLSQLEVLQHLDISDDKQFTSDVARQLLETPGILPQLVSLDVSGRKQVTDAAVKAFVEARPGMTFVGLLATDAGFSEFLSGEGSLKVTGEANETQICEALRRYSEREGFVREALFHLFSLTHAIEKPRPDILKLVALGMKNHPTTLNVQLAASACVFNLTKQELAFGIPVRLLGNVTQQLLEAMKTFPNHQQLQKNCLLSLCSDRILQEVPFNRFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLSTEQTAQLGAELFIVKQLLHIVRQKTCQSTVDATLKFTLSALWNLTDESPTTCRHFIENQGLELFIKVLESFPSESSIQQKVLGLLNNIAEVSELHGELMVQSFLDHIRTLLHSPEVEVSYFAAGILAHLTSRGEKVWTLELTLRNTLLQQLHSAILKWPTPECEMVAYRSFNPFFPLLECFQTPGVQLWAAWAMQHVCSKNAGRYCSMLLEEGGLQHLEAITSHPKTHSDVRRLTESILDGLQRHRARTGYTAIPKTQAHREKCNP", "function": "Serves as substrate adapter subunit in an E3 ubiquitin ligase complex zyg11-cul2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation.", "AFDB_id": "AF-Q5TYQ1-F1-model_v4" }, { "swissprot_id": "Q8J2Q9", "sequence": "MSLYDKSVTATRSAHRTSDTLHSLVAGSVAGGLEIAITYPAEFAKTRLQLNQVSGRNKQNVPWPRFGLQWYSGCIPFLIGNSVKTSIRFVSFDGYQKLLADDDGNISRFGILLAGFGAGATESLLAVTPSERIKTIIIEDRRLEKPRIRNSFHAMSIIARDHGLSGFFQGFWPTTARQSAGSAIRLGSYTFLKQVVQSRTPQGGKIGTVKTFIIGSLAGLITVYLTQPLDTIKTRMQRLEARTRYGNAFICARGILEQEGFTAFWSGAVARSLRLVMSGGIVFMVYEKVVEGLDVISPAKRYEIAA", "function": "Tricarboxylate transporter; part of the gene cluster that mediates the biosynthesis of fumonisins B1 (FB1), B2 (FB2), B3 (FB3), and B4 (FB4), which are carcinogenic mycotoxins. On the basis of the chemical structures of fumonisins and precursor feeding studies, fumonisin biosynthesis is predicted to include at least five groups of biochemical reactions: synthesis of a linear polyketide with a single terminal carbonyl function and methyl groups at C-10 and C-14; condensation of the polyketide with alanine; reduction of the polyketide carbonyl to a hydroxyl; hydroxylation of 2-4 polyketide carbons; and esterification of six-carbon tricarboxylic acids to two of the hydroxyls. The biosynthesis starts with the polyketide synthase FUM1-catalyzed carbon chain assembly from one molecule of acetyl CoA, eight molecules of malonyl CoA, and two molecules of methionine. The C-18 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of alanine by decarboxylation, on the carbonyl carbon of polyketide acyl chain. This step is catalyzed by a pyridoxal 5'-phosphate-dependent aminoacyl transferase FUM8. The resultant 3-keto intermediate 2-amino-3-oxo-12,16-dimethylicosane is then stereospecifically reduced to the 3-hydroxyl product 2-amino-3-hydroxy-12,16-dimethylicosane by reductase FUM13. Subsequent oxidations at C-5, C-10, C-14 and C-15 followed by tricarballylic esterification of the hydroxyl groups on C-14 and C-15 furnish the biosynthesis of fumonisins. The C-10 hydroxylation is performed by the cytochrome P450 monooxygenase FUM2 and occurs early in the biosynthesis. The C-5 hydroxylation is performed by the dioxygenase FUM3 and occurs late in the biosynthesis. Cytochrome P450 monooxygenases FUM6 and FUM15 may be responsible for the two remaining hydroxylations at positions C-14 and C-15. The FUM11 tricarboxylate transporter makes a tricarboxylic acid precursor available for fumonisin biosynthesis via its export from the mitochondria. If the precursor is citrate, the FUM7 dehydrogenase could remove the C-3 hydroxyl of citrate to form tricarballylic acid either before or after the CoA activation by the FUM10 acyl-CoA synthetase and FUM14 catalyzed esterification of CoA-activated tricarballylic acid to the C-14 and C-15 hydroxyls of the fumonisin backbone. Alternatively, if the precursor is cis-aconitate, FUM7 may function to reduce the double bond. In this alternate proposal, feeding studies with tetradehydro-fumonisin B1 suggests that FUM7 cannot function on the tricarballylic ester and must therefore act before the FUM14-mediated esterification.", "AFDB_id": "AF-Q8J2Q9-F1-model_v4" }, { "swissprot_id": "Q9RYX4", "sequence": "MKIYRSTLLHTPASPFAVPDALQTFSDGALAVGDTGTIAHLGTFTEVLAEVRAACPDAEVHDLRGGVLLPGFIDTHVHYPQVRVLGGLGMALLEWLDRNTLPEEARLADAAYARTIAGEFLHGLASHGTTTALVFGSHFAGAMDEFFAEAAARGLRVVAGQVVSDRLLRPELHTTPERAYAEGKALIERWHGQGRSLYAVTPRFSLSASEGILDACAALLTEFPDVRFTSHINENNQEIEVVRGLFPGARDYLDTYERAGLVTPRSVFAHNVHPNERELGVLAAQRCSVAHCPCSNSALGSGLFPLRRHLAAGVHVALGTDVGGGTGFSLLKEGLQAYFMQQLLGEEGAALSPAHLLYLATLAGAQALGLDGQVGDFTPGKQFDAVWLRPRAGSTLATVLAHAESEERTLAALFALGTGDDVERVWVGGGVVFAREAEA", "function": "Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.", "AFDB_id": "AF-Q9RYX4-F1-model_v4" }, { "swissprot_id": "P39012", "sequence": "MALLEKLHRRIVDMGLVPRIIALLPVISMLCALFGFISIAILPMDGQYRRTYISENALMPSQAYSYFRESEWNILRGYRSQIKEMVNMTSMERNNLMGSWLQEFGTKTAIYENEQYGETLYGVMHAPRGDGTEAMVLAVPWFNSDDEFNIGGAALGVSLARFFSRWPVWSKNIIVVFSENPRAALRSWVEAYHTSLDLTGGSIEAAVVLDYSSTEDFFEYVEISYDGLNGELPNLDLVNIAISITEHEGMKVSLHGLPSDQLTNNNFWSRLKILCLGIRDWALSGVKKPHGNEAFSGWRIQSVTLKAHGNSGHDITTFGRIPEAMFRSINNLLEKFHQSFFFYLLLAPRQFVSISSYLPSAVALSIAFAISSLNAFINNAYANISLFSEYNLVALLVWFVSLVISFVVSQAFLLIPSSGLLMTISMASCFLPLILSRKIHISEPLSYRLKNVAFLYFSLVSTSLLMINFAMALLIGTLAFPMTFVKTIVESSSEHEVTTQSSNPIKTEPKDEIELVENHMDTTPATPQQQKQKLKNLVLLILTNPFISITLFGLFFDDEFHGFDIINKLVSAWLDLKCWSWFVLCIGWLPCWLLILASSFESKSVVVRSKEKQS", "function": "Component of the GPI transamidase complex. Required for a terminal step of GPI anchor attachment onto proteins. Affects endocytosis.", "AFDB_id": "AF-P39012-F1-model_v4" }, { "swissprot_id": "P85513", "sequence": "LVSESNPGRAIPAGGKGATIRAARPGLATTLNGPKAGNGTTGATKLTTPARPLSEGANMMCDHRAGGNAAISGSSVGEGTARAGDSKVMSRMLSPKGSIIAGTVNMMPADIAAGSVRTPSSLPPDGRSATPMSVSEVASDISHKDGSVNVTKDPVTAAGLTAMRKNANKGSPPASPLPLKADNKGVHINKHWVDLKNDNDFNTR", "function": "Cleaves the glycosidic bonds of gellan backbone and releases tetrasaccharide units of glucuronyl-glucosyl-rhamnosyl-glucose with unsaturated glucuronic acid at the non-reducing terminal. The enzyme is highly specific to the heteropolysaccharide gellan.", "AFDB_id": "AF-P85513-F1-model_v4" }, { "swissprot_id": "Q0UWF1", "sequence": "MSNKPAPKSEDKAEEWSGPAATRFDKYAATQPHKAYSEYFDPCQEAADKSIRCLKRNGGERAMCTDFFQAYRDCKEQWQNARKEARRNTSWFGK", "function": "Required for the assembly of cytochrome c oxidase.", "AFDB_id": "AF-Q0UWF1-F1-model_v4" }, { "swissprot_id": "A0A084B9Z4", "sequence": "MPQDPNTTLQMSSSKPSLSDLSVSADPVLGKADNQVRDSLALPSIEGGEEGVMRPLAWLFGLCAIQQASGATLLRNDVSTVEPLPPTQDPWYRAPPGFEKKQPGDVLRIRQAPGNLTTVVSNSSAAFHILFRTTNARSEPAWAVTTLFLPKKLYRAPSRNAALLSFQLADNSANPDSAPSLGLYWRLAQDNPMLGLRSDTSFISNLLSEGWLVNIPDQSGPEAAFGASRQAGHATIDAIRAIQHLCSLTGATGINAAIWGYSGGTFATGAAAELMPTYAPNINIVGAVLGGMVTDVSGGFDSLNRSPIAATIIATLLGVTAQFPEERAYLESRLVPETRDEFMSVLDINVFDALVHFAGRDIYAFFIDGAADIEAPILQNLFEAQSRIGFGDIPPMPMFIYKAIADEVVPIGPTDVTVQRWCDGGADITYERNTVGGHIAEIENGKPRAIQWLWSIFDESYSAQSPECRIRDVTVEVPVQVVGRV", "function": "Probable trichothecene esterase; part of the satratoxin SC1 cluster involved in the biosynthesis of satratoxins, trichothecene mycotoxins that are associated with human food poisonings. Satratoxins are suggested to be made by products of multiple gene clusters (SC1, SC2 and SC3) that encode 21 proteins in all, including polyketide synthases, acetyltransferases, and other enzymes expected to modify the trichothecene skeleton. SC1 encodes 10 proteins, SAT1 to SAT10. The largest are SAT8, which encodes a putative polyketide synthase (PKS) with a conventional non-reducing architecture, and SAT10, a putative protein containing four ankyrin repeats and thus may be involved in protein scaffolding. The putative short-chain reductase SAT3 may assist the PKS in some capacity. SAT6 contains a secretory lipase domain and acts probably as a trichothecene esterase. SAT5 encodes a putative acetyltransferase, and so, with SAT6, may affect endogenous protection from toxicity. The probable transcription factor SAT9 may regulate the expression of the SC1 cluster. SC2 encodes proteins SAT11 to SAT16, the largest of which encodes the putative reducing PKS SAT13. SAT11 is a cytochrome P450 monooxygenase, while SAT14 and SAT16 are probable acetyltransferases. The SC2 cluster may be regulated by the transcription factor SAT15. SC3 is a small cluster that encodes 5 proteins, SAT17 to SAT21. SAT21 is a putative MFS-type transporter which may have a role in exporting secondary metabolites. The four other proteins putatively encoded in SC3 include the taurine hydroxylase-like protein SAT17, the O-methyltransferase SAT18, the acetyltransferase SAT19, and the Cys6-type zinc finger SAT20, the latter being probably involved in regulation of SC3 expression.", "AFDB_id": "AF-A0A084B9Z4-F1-model_v4" }, { "swissprot_id": "Q7VGD9", "sequence": "MSRALLKYIRLSPTKARLVARQVQGMNAEIAIASLEFTPNKAARVISKVIASAVANGGYDAQDVIILSCRVDAGPVLRRFMPRAKGRATPIRKPMAHILVEVGTQKSVQQSVQSTKAKAKGAKNIKSEDSKNSLKVTESKADSKVDAAQKASTTQEKAESKTKVAKAKVATTKSTATRKTTKKKTEGEEK", "function": "The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.", "AFDB_id": "AF-Q7VGD9-F1-model_v4" }, { "swissprot_id": "Q9QXC1", "sequence": "MGLLRLLVLCTLAACCMARSPPAPPLPQRPLSPLHPLGCNDSEVLAVAGFALQNINRDQKDGYMLSLNRVHDVREHYQEDMGSLFYLTLDVLETDCHVLSRKAQKDCKPRMFYESVYGQCKAMFHINKPRRVLYLPAYNCTLRPVSKRKTHTTCPDCPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQASCSLQHSDSEPVGICQGSTVQSSLRHVPLIQPVEKSVTVTCEFFESQAQVPGDENPAVTQGPQKLPQKNTAPTSSPSVTAPRGSIQHLPELDDEKPEESKGGSPEEAFPVQLDLTTNPQGDTLDVSFLYLEPGDKKLVVLPFPGKEQRSAECPGPEKENNPLVLPP", "function": "Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.", "AFDB_id": "AF-Q9QXC1-F1-model_v4" }, { "swissprot_id": "O22920", "sequence": "MELSMFGREDTNSSQWGEVHGPFMLEEIVCQAQNMLTSRGIFMKSNPLKYALPLLLLQMSVIIVTSRLIFRVLQPLKQGMISAQVLTGVVLGPSFLGHNVIYMNMFLPAGGKIIIQTLSNVGFVIHLFLLGLKIDGSIIRKAGSKAILIGTASYAFPFSLGNLTIMFISKTMGLPSDVISCTSSAISLSSMTSFPVTTTVLAELNILNSELGRLATHCSMVCEVCSWFVALAFNLYTRDRTMTSLYALSMIIGLLLVIYFVFRPIIVWLTQRKTKSMDKKDVVPFFPVLLLLSIASLSGEAMGVHAAFGAFWLGVSLPDGPPLGTELAAKLEMFASNLFLPCFIAISGLQTNFFEITESHEHHVVMIEIILLITYGCKFLGTAAASAYCQTQIGDALCLAFLMCCQGIIEVYTTIVWKDAQVVDTECFNLVIITILFVTGISRFLVVYLYDPSKRYKSKSKRTILNTRQHNLQLRLLLGLYNVENVPSMVNLLEATYPTRFNPISFFTLHLVELKGRAHALLTPHHQMNKLDPNTAQSTHIVNAFQRFEQKYQGALMAQHFTAAAPYSSINNDICTLALDKKATLIVIPFHKQYAIDGTVGQVNGPIRTINLNVLDAAPCSVAIFIDRGETEGRRSVLMTNTWQNVAMLFIGGKDDAEALALCMRMAEKPDLNVTMIHFRHKSALQDEDYSDMSEYNLISDFKSYAANKGKIHYVEEIVRDGVETTQVISSLGDAYDMVLVGRDHDLESSVLYGLTDWSECPELGVIGDMLTSPDFHFSVLVVHQQQGDDLLAMDDSYKLPNVEHQKIGDTGIQQRFSAEEGFTTIDLGKR", "function": "High-affinity potassium transporter that plays a role in K(+) acquisition. May operate as a K(+)/H(+) symporter.", "AFDB_id": "AF-O22920-F1-model_v4" }, { "swissprot_id": "Q6WAU0", "sequence": "MVMNKQIVLNNYINGSLKQSDLALRTSTICMEIPDGCNGAILVKNLYLSVNPYLILRMGKLDIPQFDSILPGSTIVSYGVSKVLDSTHPSYEKGELIWGSQAGWEEYTLIQNPYNLFKIQDKDVPLSYYVGILGMPGMTAYAGFFEICSPKKGETVFVTAAAGSVGQLVGQFAKMFGCYVVGSAGSKEKVDLLKNKFGFDDAFNYKEESDYDTALKRHFPEGIDIYFDNVGGKMLEAVINNMRVHGRIAVCGMVSQYSLKQPEGVHNLLKLIPKQIRMQGFVVVDYYHLYPKFLEMVLPRIKEGKVTYVEDISEGLESAPSALLGVYVGRNVGNQVVAVSRE", "function": "Monoterpene synthase that catalyzes the specific reduction of the 4,8-double bond of (+)-pulegone to produce both (-)-menthone and (+)-isomenthone in a 70:30 ratio. Unable to utilize either (-)-isopiperitenone or (+)-cis-isopulegone, or to catalyze the reverse reaction with (-)-menthone or (+)-isomenthone. Has an absolute requirement for NADPH.", "AFDB_id": "AF-Q6WAU0-F1-model_v4" }, { "swissprot_id": "Q755E4", "sequence": "MGLFGKDRGERIAEFPCYLLETGTHLVPLPGILYNLVIERTYGERILGQFRGIGEAVDGALTGAGEAAEVPGRVAEVMKAFQERYDSGDKTQAVYICLVTEAAAGRHIGCIARLTGARAEGGELSVLLRGLVRAVVGQPVPSRRNEMWNGSVTVLDDAQRVATWGARQLDFARQGVFGAFEELDAGIGTFTARFKSSQKRGADGAAHLLTLSPLANTLFFHFSRSSFERSWKILRTMMHGFRDAKKDIRTAMDMLSVADLTVGLLPTTTAQRLEFLQAEDPAARIKTFVRHMQQLLEVFGSLYRATEYVHDRFETHGPIAKSQLIANQLRSLRFYIDDIKRNKPESGPGGRSRRLLPRPASGNSAAAGEEDDSEDSELVAIKRYVDEIEVKGVHADGVKMLKKDYRSLSKMHVQSTEYQMLRNYFDFIMGIPFGIYVSTPEIDLVASSRKLDNDHYGLVQVKKRLLEYLCVLKLSANSPGVTADAGAIEDGSATKRAVVYENKAQEQRKTKVPFLLLVGPPGVGKTSVAKSVADVLGRRFQRISLGGIHNEAEIRGHRRTYVGAMAGMIVNALCKAGCMNPLILLDEIDKVLSVPAGAGASRLNGDPGAALLEVLDPEQNHTFTDHYVGFPVDLSQVLFFCTANDLSGMSEPLVDRMEVIHIEGYTYEEKIAIGRHFLLPKQIRLNSFDMTGINLSLTDDAWRTVVVDYTREAGVRNLDRQLGAIVRGKIVEYVENNMSGSGDDVVTQKNLPKFLGLPPHSLREEVTQTTSFAEKYGVVHGLSYNSDGTGGVLVFEVIRSGDSRDKRLTVQTTGNLGTVLSESVSIATSLVKSLLARHVVHSSADDTSVAEFFRSECHLHVPFGAVPKDGPSAGAAISLALLSLALKRPVDPALCVTGEITLRGKILPVGGVKEKLLAAQLQGMGLALVPRGNRNDLVELAEDNAETQQRLLADPALPELATLQHKLGMAVHYCSDFRDLVLHAWPTADNLWHACEDSSVRPQL", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.", "AFDB_id": "AF-Q755E4-F1-model_v4" }, { "swissprot_id": "Q84J78", "sequence": "MNSLAIRVSKVLRSSSISPLAISAERGSKSWFSTGPIDEGVEEDFEENVTERPELQPHGVDPRKGWGFRGVHRAIICGKVGQAPLQKILRNGRTVTIFTVGTGGMFDQRLVGATNQPKPAQWHRIAVHNEVLGSYAVQKLAKNSSVYVEGDIETRVYNDSISSEVKSIPEICVRRDGKIRMIKYGESISKISFDELKEGLI", "function": "Binds to ss-DNA.", "AFDB_id": "AF-Q84J78-F1-model_v4" }, { "swissprot_id": "Q9YAD5", "sequence": "MKGKGRNRAVKSLEIYVRKLAQANGIKPEMAAHIFHLIYEETPNGGISDDDLESLTGYKQSDIRRILRLLGDKRIIVSRKGRHPRKEATRYFWRIDSDTINVSLLTLKKKVLEKLVVKEAHDSGNSYYTCPRCGSKYSFDEAFTLDFTCPRCGEVLEEADSREGLERLRRTIDALREEIARDESRIYRS", "function": "Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.", "AFDB_id": "AF-Q9YAD5-F1-model_v4" }, { "swissprot_id": "P95931", "sequence": "MDIGSNEILVASDYDRTLASEENNFVISPIVSQKVNEFSKKYKFVVVTGREKKFIDKLAVGLKPTAWILENGSLILFNDREFVLCEKSWFERDRKKIIEILDNLKVRYSIGRIILYVDGYGSKLDMLSEIEKYGRIEVNRNDAMILPKGVDKGVGVLKFKELTGFKGKIIALGDSENDYALFRVADIKVAVANAIPQIKEIADIVTENPNGLGVVEILDKILSGNFGKEVDIY", "function": "Catalyzes the dephosphorylation of 2-phosphoglycolate.", "AFDB_id": "AF-P95931-F1-model_v4" }, { "swissprot_id": "O13788", "sequence": "MSNVTENKHDLHENGVPDSAQPMELDVSKKEDTEPEVRDEAKEFLLSQLPQVEVPEWAQWFDFSKVHEIEKKQNPEFFDGKNTSKTPEVYKEYRDFMISTFRLNSKVYLTFTACRRNLAGDVCAVLRVHRFLEQWGLINYNVNPDTRPSKIGPPSTSHFQILADTPRGLVPLLPPPSSSIPRSKAVTIEDPSIVRTNIYDPSLDDVLKGKGSTPNQKPSLSNLHENNIDQSDSPQHCYCCGNKFNESYYQSQTAQKYNVCISCYQQNRFPSPTTIADYKEVAIQNKIEDDDTWTAQELVLLSEGVEMYSDDWAKVASHVNTKSVEECILKFLNLPSSDKALFKMDKVHTNPVVDSLQGKNPILSVVSFLAKMVPPSSFTQKSSAKEEESDKVKGESVYPKPESESYDVEMNGKSLEDSDSLSELYLTNEEKKMASIIKDSVNVQIKLIESKLSHFDYLDQHIRLKSQELDAFAQATYREKLYMKRECQNARKKIEQQLQSKDTAANGLPVQSSAETSVIPASSMSPS", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.", "AFDB_id": "AF-O13788-F1-model_v4" }, { "swissprot_id": "O24210", "sequence": "MAAPREPEVIRDKAAMRAWSRRRRAEGKTVAVVPTMGYLHQGHLSLISAAAAAASADPVAIVVTIYVNPSQFAPSEDLATYPSDFAGDLRKLASTGVVDAVFNPPDLYVRGAGRRGAASGGAISCLEEAAGDGHETWVRVERLEKGMCGASRPVFFRGVATIVSKLFNIIEPDVAVFGKKDYQQWRVICRMVRDLDFAIEIIGSEIVREADGLAMSSRNVHLSREEREKALSISRSLVDARTGALKGNTDCKQIKNKIVQTLTETGGQVDYVEIVEQESLVPVEQIDGPVVICVAAWFGKVRLIDNIEIDTRS", "function": "Catalyzes the condensation of pantoate with beta-alanine to form pantothenate. Essential for panthotenate biosynthesis (Probable).", "AFDB_id": "AF-O24210-F1-model_v4" }, { "swissprot_id": "Q12XX5", "sequence": "MKHIIFTDLDGTLIDHDTYSYDAARPALDLLKEKEIPLIFCTSKTRAELEVYVDELECHHPFISENGGAIFIPKDHFSIELKDVHEIGNYKVIEFGTSYTRIRGVLEDIRKKTGFKITGFGDLDAEGVSKDTGLDIRSAKLAKLREYDEAFRLEEDENATAKVIELIHAAGLNYTKGGRYWHIMGDNDKGKAVRALTEIYRQQFTEVVTIALGDSLNDLPMLKAVDIPFLVQKPDGKYDPSIILTEIKHAEGIGPVGWNNAIMDLIGKNNNI", "function": "Involved in the biosynthesis of glucosylglycerate. Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) and mannosyl-3-phosphoglycerate (MPG) to glucosylglycerate (GG) and mannosylglycerate (MG), respectively.", "AFDB_id": "AF-Q12XX5-F1-model_v4" }, { "swissprot_id": "Q4JB80", "sequence": "MIVIFVDFDYFFAQVEEVLNPQYKGKPLVVCVYSGRTKTSGAVATANYEARKLGVKAGMPIIKAMQIAPSAIYVPMRKPIYEAFSNRIMNLLNKHADKIEVASIDEAYLDVTNKVEGNFENGIELARKIKQEILEKEKITVTVGVAPNKILAKIIADKSKPNGLGVIRPTEVQDFLNELDIDEIPGIGSVLARRLNELGIQKLRDILSKNYNELEKITGKAKALYLLKLAQNKYSEPVENKSKIPHGRYLTLPYNTRDVKVILPYLKKAINEAYNKVNGIPMRITVIAIMEDLDILSKGKKFKHGISIDNAYKVAEDLLRELLVRDKRRNVRRIGVKLDNIIINKTNLSDFFDI", "function": "Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.", "AFDB_id": "AF-Q4JB80-F1-model_v4" }, { "swissprot_id": "Q67Y69", "sequence": "MAGEIQDPFSLSFQGNSIHSGSISFGRFEKEGLSWEKRSSFSHNRYLEEVDKCSKPGSVTEMKAHFEAHFKKKGIRFPASLESQTWGVHQTSNEPDDEAVHATESFEDYRSDGSFSEDTSQSNSVCNYSHEQEKCGQGKSQCEFDEESDHCVSYDEILVNSDEVIELDEEEGGGDHGRVADLVECENLGPPEMPQEIVIQDSALVEEAGSKLDEHASKKPSNSMETPSSSVNVKPIIPNDVRVTKASTKGHDVTPKAASRRTKGSSLSSNSKTNVDAKSQKELRPKKTIESQPKSSNKTETRPPIATNRCKTSTTSSKLEMSTGSTSFRFKCSERAEKRKEFYMKLEEKIHAKKTETNQVQAKTQQKAEAEIKQFRKSLNFKATPMPSFYNIGTRPVSHNKTEPSKVAQSRSRPATSASITNRAVTRVSYKHGFEEAEMVKVMVSNRKQSAAKDSDLQKGNLMAVEMKQQIGARRSRN", "function": "Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules.", "AFDB_id": "AF-Q67Y69-F1-model_v4" }, { "swissprot_id": "Q9Y948", "sequence": "MPSARDILQQGLDRLGSPEDLASRIDSTLLSPRATEEDVRNLVREASDYGFRCAVLTPVYTVKISGLAEKLGVKLCSVIGFPLGQAPLEVKLVEAQTVLEAGATELDVVPHLSLGPEAVYREVSGIVKLAKSYGAVVKVILEAPLWDDKTLSLLVDSSRRAGADIVKTSTGVYTKGGDPVTVFRLASLAKPLGMGVKASGGIRSGIDAVLAVGAGADIIGTSSAVKVLESFKSLV", "function": "Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.", "AFDB_id": "AF-Q9Y948-F1-model_v4" }, { "swissprot_id": "P0CT28", "sequence": "MSNGTPSVRVLYFASARTTIGHSSETISLPTTPFPLASLITLIANKYSSRGAEAVLRTCRWSVDNTLIEIDELIEWTLHGREEVAAIPPVSGG", "function": "Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.", "AFDB_id": "AF-P0CT28-F1-model_v4" }, { "swissprot_id": "Q8F8T4", "sequence": "MKQDSQSENESIVCDLSVSEDQRNVKFFSDLQTPIPKHLPFFMDVTLRDGNQALRRPWNLEQKETIFKQLLKLGVQGIEVGFASSNNQEFEACKYLSSIAPDNVVISSLSRAVEKEIEVSWKAIRFAPKPRIHIVYPVSAFTIQNVLKISPEKVLDRISQSVAYAKSLVGSKGEVQFSGEHFGDSLENLDFAAEAFQIALNNGADVVNLPNTVERYRPWLFVSMVKAVANLLPEDTRISIHTHNDLGMATATTVESYFAGAVQLETALNGLGERAGNTNTYEVAIALHNCGVEVPLNFSTIYETSRLVSYLSEIPIYEKAPLIGEDVISHRSGIHQDGVAKTRHLQKGAYRAFDAALIGRPEGDRIEFTNQSGKSAVYCILKDAGENITLEEAGRLQPILKKISEDLGRRELTLEEIRIEWNRLLRAI", "function": "Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Also has low citramalate synthase activity.", "AFDB_id": "AF-Q8F8T4-F1-model_v4" }, { "swissprot_id": "Q550G0", "sequence": "MIPKQPKSNILIFLLENSDHLGLLKSLITFLPGRYGDSELFSEGLYSVANILQSYLDYRSSGILLSNNIDKISNGEKVPPPYYLTTLRWITTVQSLELFFEMLATKKGEQHDDSNSNNNNSNNNIKKMIIFIIELLKAILRLKLLIKTNGDMLVHHSFYVPSKDVKTILENNRNQQKQFQNKRPAVTMSINNNNNINNNDNNNINNNNNTNDDNFNNNNNNNNNRRTLSDQIFEQQRIVNQENNLLYQQQRELQQNESTLIKLLPPPPPKDYNTKTIGEILFIFRPVIYWVSYCIFGKKSWKPWFLSLVTELLSKSFSEYGNFKQKIRLTLLEAKELNRRKKLLFFYLIRSPFYEKFIGDGLLNKFLNFLKKIHIFKTLIDILINYLNVYRTRYFYTSAS", "function": "Required for peroxisome membrane biogenesis.", "AFDB_id": "AF-Q550G0-F1-model_v4" }, { "swissprot_id": "Q06139", "sequence": "MQSISNCPIGLVSKNTINSASTIAEWVACPWKYINVVGSGRYVSNKPDKITRYDLLKAAQEAEMQELLTRNDMKGRHKRNKKSKIALETIAEENSSTESLF", "function": "Mitochondrial protein that is involved in citrinin resistance.", "AFDB_id": "AF-Q06139-F1-model_v4" }, { "swissprot_id": "P34758", "sequence": "MSFDWLNVPGLDLSSGDQAEKRPSNGLGPPSVSFDFGINTAAPHDSSFWDQGSRSHSDTTLSYRNNHSNTAADNATNVSSPQKDNPPNGEVRTLSGGDVYAESPEDMQVPLSLSQNQLTHEEIRTYLRWYHYICLRTHGKLVRLNDVFRFLTNFNLSQKVKDRIVEIFRSCKNALNIGQFFAVLRLVSRAIIYGILPLRRMILEKAPVPKPRPILSSENHEEVYEEVEDDDSSAKTGDQKVDFDSFASLLLTGKTTRKRVRRRIKNLNFKSKKVRFSEHITFQDPPNLNQESSNNSEARKQDPDAEDEDQDSNNDSPLDFTLPMDQLLKRLYKRRKNSGLVSSLPSEQQETEEEKKVLEDMKDSLSHFKQIQTVDSASLPISSVFLQNGNTLPTSNVNNTTVPQQLPLEPLKPTATGSANHLVREEYNQGLHPSNGAIQTGLQPLKPTATGSANYLMRSHMEQPQSIKPSSTPETVTNSGGLQPLKPTATGSANYLMKQHISPSVNNPVSSMFQAQFTNQSSSPQSTGPAFLNSPNITLPQSNQQQPYQEVNPTQAKIEPSNISPQHTYSNNVRINNGNIVSMPKVEITGAFPPQNTLPQHQQSHLLSPQNTIPQHQRSQLISPQNTFTQNQPILSPQHTYSNNQATMISPQNTYTNNQQQPQHLPPPPPPRAQQQQQGAIVPPQHMYSNVQKQNNLVPTQPSYTNSPSIQSPNFLSPQNAANSYFQSLLSSSPSPNPTPSNASTVNGNNASNGISSFQNTSAAMNNTQSHQTYIQQQQQQQTQQRIYGGQLSQMQQHPGQLHLNNSDIHSQPNKPNYGMLGQQVHQQQQQQQQQFPFTADVNRSNSSDILGNLQSLQQQVDALQIQYNRRP", "function": "Regulates both fluid phase and receptor-mediated endocytosis. Involved in vesicular transport at a late stage of the secretory pathway. Regulates actin cytoskeleton organization.", "AFDB_id": "AF-P34758-F1-model_v4" }, { "swissprot_id": "O33833", "sequence": "MFKPNYHFFPITGWMNDPNGLIFWKGKYHMFYQYNPRKPEWGNICWGHAVSDDLVHWRHLPVALYPDDETHGVFSGSAVEKDGKMFLVYTYYRDPTHNKGEKETQCVAMSENGLDFVKYDGNPVISKPPEEGTHAFRDPKVNRSNGEWRMVLGSGKDEKIGRVLLYTSDDLFHWKYEGVIFEDETTKEIECPDLVRIGEKDILIYSITSTNSVLFSMGELKEGKLNVEKRGLLDHGTDFYAAQTFFGTDRVVVIGWLQSWLRTGLYPTKREGWNGVMSLPRELYVENNELKVKPVDELLALRKRKVFETAKSGTFLLDVKENSYEIVCEFSGEIELRMGNESEEVVITKSRDELIVDTTRSGVSGGEVRKSTVEDEATNRIRAFLDSCSVEFFFNDSIAFSFRIHPENVYNILSVKSNQVKLEVFELENIWL", "function": "Hydrolysis of sucrose, raffinose, inulin and levan. Specific for the fructose moiety and the beta-anomeric configuration of the glycosidic linkages of its substrates. The enzyme released fructose from sucrose and raffinose, and the fructose polymer inulin is hydrolyzed quantitatively in an exo-type fashion.", "AFDB_id": "AF-O33833-F1-model_v4" }, { "swissprot_id": "P29506", "sequence": "MIGALHACVDAEPKIINDIWADFWKSQINSVLLNPSDGSETYLASDNGKSTSSREQSTSPDDDNLLMNEDDGIALEDDNDTGESAAKRRRTRTNFSGWQLEELESAFEASHYPDVFMREALAMRLDLLESRVQVWFQNRRAKWRKREQNRNGSSEIKKDDGEQMETKALPTFPFSIDSILAVSRVPRGRRPNAKYPRVQACKNLSPFMIPLFPITQPGGNVIREKSPPLPTQQSQIVATNALTTVAELLKSV", "function": "Transcription factor. Involved in motor neuron fate determination and maintenance. In concert with unc-37, represses the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neuron fate. Regulates synaptic specificity and the pattern of synaptic input to VA motor neurons, and, depending on context, acting in opposition to, or supported by, Wnt signaling. Required in patterning of the synaptic outputs of the postmitotic DA class cholinergic motor neurons. Acts as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons, probably by binding to specific promoter elements. Has no role in axonal guidance or outgrowth.", "AFDB_id": "AF-P29506-F1-model_v4" }, { "swissprot_id": "Q01766", "sequence": "MHFKDLGLHDYTLKNLMYENNCCKFYDAVDENNISYVLKFVPSDVTSEGDTFPFVDRFQVKEGVFLVYSSNDFGKEGTDYFTYTGSGGNEVHISGTSSEAGIKPQFIETCHPKHLKRGTKEQEDINSSTSKKSAVINNFSGEKTPNPRPQSSNISERETYVGILNVKCKNKNSSKIRSEKLVSSVIETKHTPGLASILSKEGTTYPNNADGKHISIVNPSSKIYHSSHKQIVKTPIPKSGLSPIERCPFNGQNIKCYSPRPLDHESPQRDFNNNFQLRILKSSVLQRRQSTQNS", "function": "Involved in salt tolerance.", "AFDB_id": "AF-Q01766-F1-model_v4" }, { "swissprot_id": "Q8REH1", "sequence": "MKIAIYGGSFNPMHIGHEKIVDYVLKNLDMDKIIIIPVGIPSHRENNLEQSDTRLKICKEIFKNNKKVEVSDIEIKAEGKSYTYDTLLKLIEIYGKDNEFFEIIGEDSLKNLKTWRNYKELLNLCKFIVFRRKDDKNIEIDNEFLNNKNIIILENEYYNISSTEIRNKVKNKEDISGLVNKKVKKLIEKEYID", "function": "Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).", "AFDB_id": "AF-Q8REH1-F1-model_v4" }, { "swissprot_id": "Q96AQ8", "sequence": "MDCGSVGGQRTQRLPGRQRLLFLPVGLSGRPGGSETSARRCLSALSDGLGALRPRAPAARGGVSRASPLLLLLLVPSPRLAAAAPRRQLGDWERSRLGYAAPPAGRSSAWRCSPGVAAAAGALPQYHGPAPALVSCRRELSLSAGSLQLERKRRDFTSSGSRKLYFDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNEKKLLELRTEIVALHAQQDRALTQTDRKIETEVAGLKTMLESHKLDNIKYLAGSIFTCLTVALGFYRLWI", "function": "Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex).", "AFDB_id": "AF-Q96AQ8-F1-model_v4" }, { "swissprot_id": "Q55DV8", "sequence": "MSKPDLNSLSIKMKQINLLKERFSHTIEVVKDSTFKIPFLNVHLLISLPVNFPNSPPAYFLEILQTHQPVSLPPNYQWTQISNLASVTVHIMEPFIKDSRILETLIEQVKRSQAMQQQQQQQQQQQRNQQAQQQYSPPPPYKDQPINKQPAQQQPQPVQQKPQQQQNGTNKIPMIPTEFPELKSKSVEELEELLKNEDSLNAFIYSYDEVSELSNRKSKLLSENERLTKITDPLPNDINDLSANLMTSKQKLEELKRKQEQLQQKKNSIADKYSQQNLLEILNDSISDLESESDNIVHSFLEGNLELKEFKKQFKEKRSSYHSKCANKDLFFK", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process.", "AFDB_id": "AF-Q55DV8-F1-model_v4" }, { "swissprot_id": "Q0S7M1", "sequence": "MGSFPCPQKIEQVLLSGQGLNELSFASRPACASMLVERVPHHGVVYGLGQETAVAQPNLPEGFDFTDPDVYAERIPYQEFAELRKTAPIWWNPQPPEIGGFHDDGYWVVSKLEDVKEVSRRSDVFSTHENTAIVRFADDIPRENIEMQRFILINKDAPEHTKLRKLVSRGFTPRAINSLREELTERAEKIVKEAAESGAGDFVTQVACELPLQAIAELLGVPQEDRLKVFDWSNQMTGYDDPELDIDPQAASMEILGYAYQMADERKKCPADDIVTTLIEADIDGNELSPEEFGFFVILLAVAGNETTRNAITHGMMAFLDHPDQWELYKKERPKTTADEIVRWATPVNSFQRTALEDTELGGVQIKKGQRVVMLYGSANFDEDAFENPEKFDIMRENNPHVGFGGTGAHFCLGANLARLEIDLIFNAIADHLPDISKLGDPRRLRSGWLNGIKEFQVDYKTASGGCPVRH", "function": "Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.", "AFDB_id": "AF-Q0S7M1-F1-model_v4" }, { "swissprot_id": "Q9I069", "sequence": "MSQLPIPLPLNESRWRYVTASGGGMTVAFLAGSGGSITLLSPEGENVSFRYGGVGGGIGLGMRLPRFGKVNLNVKGKSVGGAGALEALPSTGTVLVADGLVGRDLSRGDFTGPCMYVELGAGVIAGGSGTAILFGLDPKLLAAVALASASPLTAALGASMSRQLLQSSRGALLMAGVNVGAQFGGGAAAYLGALF", "function": "Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells.", "AFDB_id": "AF-Q9I069-F1-model_v4" }, { "swissprot_id": "Q8RIS8", "sequence": "MKRPPHHPVTVADVGGTHLRWARWSPDGGLGEVHTTPSPGHARRPGAGAADLQAELIRELASRVEPGARAGVSLGAAMDHHSGTAYASAPLWGPQVSPFDVPAALRAARPDVHWTVVNDVTAGLLHLAEMVRDAGVRKACLVTISTGIACRTMDLRTGGIPVDAAGLQGEIGHLPATVLADGVPVVTRCDCGEPGHVAASSSGPGIRRVAAVLARRDPATWAGSGPTTRMMAGSGFEDAFRAALDDGDPVAADLLTAVTAPIADLLRTALCLDPELDLIALTGGVAHGLEPHYSAAVHDHLRRRGLYLTSEREPDWLTGRIRVVPPATADPLVGAGLAALAAGPVPAYSGGGREALVGR", "function": "Catalyzes the conversion of 2-epi-5-epi-valiolone to 2-epi-5-epi-valiolone 7-phosphate. Involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose.", "AFDB_id": "AF-Q8RIS8-F1-model_v4" }, { "swissprot_id": "Q6FP19", "sequence": "MAKRHKHFESRGGFRKKRGGGRGSQRGRGSKRGRGGRFRGFEETERSASEPGAWLNSSVPLGDGDLSNPDMMVDNYRPRKHISQDTITDHYFGRKSSLKLNSMRMAGLRHNDWRDPNNGNSASFRKRPIEFIKANCTYDPSRDLILQLANRSKNQESKEPEEDANKCSEYAEHSEKDMEIDTAATENDANISYDESDTDQEIGNFNHSIENSKHNNNISECDITAVTDQELFFVDEEGMDISQKPTKVVHITEHEKKMGSNVEFHNVLTVGKVEISLNQDENDEVYVDRKPTAKYHPFHNYISNVIERMQEEENIDSDDFEDEDDIYLDNSGNDMPETELDQDEIIDLQRHDDKDHAVQTCAIPTNTLSNDLDTLHITESNDDRITINNHNMDSTVETDKEKDPEFGFLEEDYAVNTSEVIVDNIRLGLNDNSYFLKCYRFFGDYSFHWIDQEAFVSFLTEDLELPMNRVGAYLAYVKNSLVPDETPPSPTYSDIPFSDTSNESDEDNALPNVDAVSSCSNDDEDEELGDDVDDLVSYSLKYANSRNIDYETRALEFTGKGKKKKLLVNEQLDLDNETMETLQAKLSKRMENKAKKRRLKEDFIDKENMNSDDLFLKYPYGFHVQNIRDEFELFLTRNKDRMSFPPLDPHGNKVITKFATCYNIKSSKVGKGNHTHIMVEKVKKTKWSRPNYNMVLQLTRQRPVFMRIDVRRPKEDAIKENSGRRGPTAKFHVKEGEVVGENAPEIGQDNIGRRMLEKLGWSSGEGLGAHGNKGISIPVMARVKKSKSGLRHSKEDEDTGRSSSFRKK", "function": "May be involved in splicing.", "AFDB_id": "AF-Q6FP19-F1-model_v4" }, { "swissprot_id": "P17551", "sequence": "MNSPQPPDTTAAGSVHTAPTYTLRQLVMYFLRLGTLGFGGPVALAGYMHRDLVEAKQWITDADYKEGLALAQLAPGPLAAQLAIYLGYVHYRIVGATLVGVAFVLPSFLMVLALGWAYVRFGGLTWMQSVFYGVGAAVIGIIAISAYKLTKKSVGNDKLLWFIYLVLVAVTVITESEVAWLFLAAGVLVWFWRAPPKWLRQGKMNAFAATPLPAASGMMSTLDWPLLSQIGVFFAKAGAFVFGSGLAIVPFLYGGVVTEYHWLNDKQFVDAVAVAMITPGPVVITVGFIGYLVAGLPGACVAAAATFLPCYLFTVLPAPYFKKYGKLPAILAFVDGVTAAAIGAITGAVIVLAKRSIVDIPTALLALVTVALLLKFKKLSEPMIVAGAALIGLVAYPLLHH", "function": "This protein reduces chromate accumulation and is essential for chromate resistance.", "AFDB_id": "AF-P17551-F1-model_v4" }, { "swissprot_id": "Q99MR1", "sequence": "MAAETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFAAVLQEEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLPATSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKPARRDGVRSGFEEGGAGPRKEHARSDSENWRSLREEQEDDGSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGERRRKFDFDLRGERGGCGEEDGRVGGGNSHLRRCRGLDGFEDDKDGLPEWCLEDEDEEMGTFDASGAFLPLKKGPKEAIPEEQELDFRGLEEEEEEEEEPSEGVDEERPEAGGKEATPLPPPENSSSPSSLPALGPLWTTNEEGGEAVEKELPPAEGDELRGLSLSPRISSPPGPPGDLEDEEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSTAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQHFLQLVGSRQLPQCTTLREKAAMGDLTPPQQQQLTTFLQQLQALKTPRGGDQNLLPTMSRSLSVPDSGPLWDLHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQQQEEQKRRQEEEELFRRKQVRQQELLLKLLQQQQATNVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQAAPREPLRAQAPNHRVQLGGLGSAPLNQWVSEAGPLWGGPDKSGGSSGGNLGLWEDTLKSGGSLARSLGLKSSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTAGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQQQQQQQQEAWLSSTSLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY", "function": "May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1.", "AFDB_id": "AF-Q99MR1-F1-model_v4" }, { "swissprot_id": "Q8KWT5", "sequence": "MKTEQDLQELYFPTPKLIEWDNGVRQYSSVRGDTEVLLSYVPPHTNVEPHQHKEVQIGLVVSGELSMTVGDVTRKMTALESAYIAPPNVPHGARNETDQEVIAIDIKRLKAGETYTSPEDYFLNIFKTRDLLPGMEVTFFVEDWVEIMLANIPGNGGEMPFHKHRNEQIGICIGGGYDMTIEGCKVDMTFGTAYFCDPREDHGAINRFEKDSKSVNIFFPPRYNRAKAKKLEAKES", "function": "Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the endocyclic-delta(4),delta(8)-7R-dihydro-hydroxyphenylpyruvate (en-H2HPP) to generate a mixture of 3E,7R- and 3Z, 7R-olefins of the exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP).", "AFDB_id": "AF-Q8KWT5-F1-model_v4" }, { "swissprot_id": "P51998", "sequence": "MTIKRNLVKTLQSIRYQATTATAHAESTLNPLPNAAIPPKYALVTVRSFPSLEPLTFVPVPTSTVAAPLRRDILWRAVVYENDNRRVGASNPPGRSENGFSRRKLMPQKGSGRARVGDANSPTRHNGGRALARTAPNDYTTELPSKVYSMAFNNALSHQYKSGKLFVIGGEKVDLISPTPELDLNRLDLVNTNTVEGKEIFEGEVIFRKFLEEFQLKGKRLLFITDKTREGLIKSSDPYKQKVDVIQKELVEVNDILRAQAVFIELEALEYLAMAHQKEILHSVSN", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.", "AFDB_id": "AF-P51998-F1-model_v4" }, { "swissprot_id": "P40380", "sequence": "MEPSTPPMRGLCTPSTPESPGSFKGVIDASLEGNSSIMIDEIPESDLPAPQVSTFPPTPAKTPKKQLLPNLMLQDRSNSLERCMEEDREHNPFLSSSDNQLLSRKKRKPTPPPSDGLYYVFRGKRIKKSFRPGTDLSTFKPKLLFADSAPSSSSDNPTSSVDLNDYSQIGILPPNLNSIGNKMFSLKSRVPSSSSGSFVAPPPQMRLPAYSSPQKSRSNTKDENRHNLLR", "function": "Regulator of cell cycle G1 phase progression. Ensures the correct sequence of S phase and mitosis in the cell by acting as an inhibitor of the cdc2 mitotic kinase. Probably interacts with cdc2 to inhibit its action until the cell mass for Start is reached. Determines the length of the pre-Start G1 period and prevents mitosis from happening in early G1 cells. Required for maintaining pheromone-induced G1 arrest. Acts as an adapter protein since interaction with cdc13 promotes cyclin proteolysis during G1. Becomes a target for degradation at the G1/S phase transition, following phosphorylation by cig1-associated cdc2 at the G1/S phase transition.", "AFDB_id": "AF-P40380-F1-model_v4" }, { "swissprot_id": "A2RMJ9", "sequence": "MTNNQKVKTLTYSAFMTAFIIILGFLPGIPIGFIPVPIILQNMGIMMAGGLLGPKYGTISVGAFLALALIGLPVLTGGNGGAASFLGPSGGYRIAWLFTPFLIGFFLKKLKITTSQNWFGELIIVLLFGVIFVDFVGAIWLSFQSNIPLLTSLISNLVFIPGDCIKAILTVVIVRRLRKQGGFELYFRK", "function": "Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins.", "AFDB_id": "AF-A2RMJ9-F1-model_v4" }, { "swissprot_id": "Q6AYL9", "sequence": "METLSFPRYNIAEIVVHIRNKLLTGADGKNLSKSDFLPNPKPEVLYMIYMRALQLVYGVRLEHFYMMPVNIEVMYPHIMEGFLPVSNLFFHLDSFMPICRVNDFEIADILYPKANRTSRFLSGIINFIHFRETCLEKYEEFLLQNKSSVDKIQQLSNAHQEALMKLEKLNSVPVEEQEEFKQLKDDIQELQHLLNQDFRQKTTLLQERYTKMKSDFSEKTKHVNELKLSVVSLKEVQDSLKSKIVDSPEKLKNYKEKMKDTVQKLRSAREEVMEKYDIYRDSVDCLPSCQLEVQLYQKKSQDLADNREKLSSILKESLNLEGQIDSDSSELKKLKTEENSLIRLMTLKKERLATMQFKINKKQEDVKQYKRTMIEDCNKVQEKRDAVCEQVTAINQDIHKIKSGIQQLRDAEKREKLKSQEILVDLKSALEKYHEGIEKTTEECCTRIGGKTAELKRRMFKMPP", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.", "AFDB_id": "AF-Q6AYL9-F1-model_v4" }, { "swissprot_id": "Q92ET8", "sequence": "MFPFERQNKIIHLLDQNNKITVPELSRILDVSISTIRNDLSALEESGMIKKVHGGAVLLKSEEKFTNFNDRIIRNIEEKEAIAKEAATLVKNNQTIILDASSTALALAKELHGFSRLTVITSGLYTAIELKDNPNISVILTGGIVTTNSFTLEGILGANLIENIHADLCFMSAKGFTMEEGLTDFNIYETELKRLLAKRTNKLVALLDHTKMGVISTASITTAENIDLLITDNKINKALYKKFQDAGLPVKIAE", "function": "Involved in the glycerol metabolism. Repressor of the gol operon for glycerol metabolism.", "AFDB_id": "AF-Q92ET8-F1-model_v4" }, { "swissprot_id": "P47146", "sequence": "MSWRYSILTVDGSFKIFIPWEIFLTWNFLSAAWLNSTESNTYIHYSTCWGTSDYTLNISVIEATTEKLVDTRLLTTLENATAWINSNSIDEDEDDMPHATNVADRLDGLSLSKRVYSICHYEF", "function": "Required for normal microtubule organization.", "AFDB_id": "AF-P47146-F1-model_v4" }, { "swissprot_id": "A8ERK3", "sequence": "MSQFLYLVPTLTILVGALVLMFMSMYDKFNIKNHIFASSVFLIIALLFALSNVSNSFSVQPYESFLNNVLTFDSFSNFFNILLIAGTLLTLLIGEHYFQHRSYFKGEFFSILLFALFGMMVLAQANELITAFIALEIASFSIYIMVGYNSDDSKRVEAIFKYLVLGSFIGAFYLLGMVLVYGATTSTNLADVSTFIATANQQDMILVYIGLTLILFTFLFKIAAFPFQSWLLDVYRGAPMIITAYMASTFKIAIFSFFLRVILDYISPIIDFWDTILSVVIILTLVFGTWLAVTQQIVKRMLAASSIVHTGYLLLAFIALGYKDGHLINIDSAYAVMFYLIAYLLSALGAFGLASHIISETNVKVTFDDFKGLAKQRPFLAAMMTIFLLSLAGIPSTIGFIGKIYVFTEAIASGYTLLTVIAILATIVSVYYYFRLIAVMYFYPAPDNCETEEFDDKRVSTYAIMFVAILTVLGGIGSAIVFFIPAMNIDTLINFSQVAVQSLFIR", "function": "NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-A8ERK3-F1-model_v4" }, { "swissprot_id": "O25045", "sequence": "MLLKNASFYDDEVLKRADIRLKDSLITEIKENLSPINNEEVIECRDLFVLPSFIDLSVTGLEGYENLKQKAFKGGVGLLNVFNCDQSGIKNIMAIKNNQLADIATLKNKGGEILIAPSDAFLELISHYAKSYNLPLLISLENSFEALNSGELAYELGQNFVENAFENTRLVRFMEVSRALQIPVLLDKVNSITTLKLIKAFNDLGAKLQAQTPLSHLVLDESVYEDYEPRFKIAPPLRDKESQNALKEALKNNEIAMLTSLHASKNSNAQLFEESAFGCESIEDAFSVAYTFLVQKKVISFQQLIKVMAINQAKFLKLNAGEVKENQLANLMIVDLNAQTRVSNQNSPFYGLELYGEVQRMILKGQTTFIKENACKKS", "function": "Non-functional DHOase.", "AFDB_id": "AF-O25045-F1-model_v4" }, { "swissprot_id": "Q93971", "sequence": "MMSDDMLDENDENFACQDVDEIIIYVPEFAGYREVNIDTAVSVCPTPIQQARRESSCRNLEMRRRFEKLRREKKEEKKLLADDEKDFDEDDDVFEDGEGLQMRTFQPNASIRDENGSMPSLLPRTAPIKKTRKHRRRRSGSFTGGVYPRKGHRNRSLLGHAIPPPNVHSADWRDMLAITDNKDDKLMKTLGVTRYLQSKGGDQVPPTSTTTGGAGGDGNAVPTTSQAQAQTFNSGRQTTGMSSGDRLNEDVSATANSAQLVLPTPLFNQMRFTESNMSLNRHNWVRETFTRRECSRFIASSRDLHKCGCGRTRDAHRNIPELTSEFLRQKRSVAALEQQRSISNVNDDINTQNMYTKRGANEKWSLRKHTVSLATNAFGQVEFQGGPHPYKAQYVRVNFDTEPAYIMSLFEHVWQISPPRLIITVHGGTSNFDLQPKLARVFRKGLLKAASTTGAWIITSGCDTGVVKHVAAALEGAQSAQRNKIVCIGIAPWGLLKKREDFIGQDKTVPYYPSSSKGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKRLEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLAFAHQNVTEDGLLPDDIRRQVLLLVETTFGCSEAAAHRLLHELTVCAQHKNLLTIFRLGEQGEHDVDHAILTALLKGQNLSAADQLALALAWNRVDIARSDVFAMGHEWPQAALHNAMMEALIHDRVDFVRLLLEQGINMQKFLTISRLDELYNTDKGPPNTLFYIVRDVVRVRQGYRFKLPDIGLVIEKLMGNSYQCSYTTSEFRDKYKQRMKRVKHAQKKAMGVFSSRPSRTGSGIASRQSTEGMGGVGGGSSVAGVFGNSFGNQDPPLDPHVNRSALSGSRALSNHILWRSAFRGNFPANPMRPPNLGDSRDCGSEFDEELSLTSASDGSQTEPDFRYPYSELMIWAVLTKRQDMAMCMWQHGEEAMAKALVACRLYKSLATEAAEDYLEVEICEELKKYAEEFRILSLELLDHCYHVDDAQTLQLLTYELSNWSNETCLALAVIVNNKHFLAHPCCQILLADLWHGGLRMRTHSNIKVVLGLICPPFIQMLEFKTREELLNQPQTAAEHQNDMNYSSSSSSSSSSSSSSSSSDSSSFEDDDDENNAHNHDQKRTRKTSQGSAQSLNITSLFHSRRRKAKKNEKCDRETDASACEAGNRQIQNGGLTAEYGTFGESNGVSPPPPYMRANSRSRYNNRSDMSKTSSVIFGSDPNLSKLQKSNITSTDRPNPMEQFQGTRKIKMRRRFYEFYSAPISTFWSWTISFILFITFFTYTLLVKTPPRPTVIEYILIAYVAAFGLEQVRKIIMSDAKPFYEKIRTYVCSFWNCVTILAIIFYIVGFFMRCFGSVAYGRVILACDSVLWTMKLLDYMSVHPKLGPYVTMAGKMIQNMSYIIVMLVVTLLSFGLARQSITYPDETWHWILVRNIFLKPYFMLYGEVYADEIDTCGDEAWDQHLENGGPVILGNGTTGLSCVPGYWIPPLLMTFFLLIANILLMSMLIAIFNHIFDATDEMSQQIWLFQRYKQVMEYESTPFLPPPLTPLYHGVLILQFVRTRLSCSKSQERNPMFDFSLKLFLDNDQIEKLHDFEEDCMEDLARQKLNEKNTSNEQRILRADIRTDQILNRLIDLQAKESMGRDVINDVESRLASVEKAQNEILECVRALLNQNNAPTAIGRCFSPSPDPLVETANGTPGPLLLKLPGTDPILEEKDHDSGENSNSLPPGRIRRNRTATICGGYVSEERNMMLLSPKPSDVSGIPQQRLMSVTSMDPLPLPLAKLSTMSIRRRHEEYTSITDSIAIRHPERRIRNNRSNSSEHDESAVDSEGGGNVTSSPRKRSTRDLRMTPSSQVEESTSRDQIFEIDHPEHEEDEAQADCELTDVITEEEDEEEDDEEDDSHERHHIHPRRKSSRQNRQPSHTLETDLSEGEEVDPLDVLKMKELPIIHQILNEEEQAGAPHSTPVIASPSSSRADLTSQKCSDV", "function": "Required for initiation and continuation of postembryonic mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. May be a cation channel.", "AFDB_id": "AF-Q93971-F1-model_v4" }, { "swissprot_id": "P16643", "sequence": "MTDLKITLVNEDGESTISGKGHPLPAPLIFPPIYCFCFIQYKTEGKLWDKNDFQIKSGKIEFGGEEYDITESKGTWSKDDEENHIKVSLHLIVPPKKIFQKNF", "function": "Cell-cell adhesion during early development.", "AFDB_id": "AF-P16643-F1-model_v4" }, { "swissprot_id": "Q9VVG4", "sequence": "MLSIGAMANIKHTLQKELFLASGERLLSVVTVVKKKDKKPCYLCVVTTAPPVPVVTLCLIKQSEQREGEYKRKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVRGQRAEFRNVPAAWLSEKSPEKVALGRAVQKTQHMDDEEDEEEEAQEFTALTDKEANELGKLFSECDFAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDILGHVKETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAIAAAQCLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFIHLGNEIGDMQVTSTELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYDRDVRNFFNLAKIQVTEKLRNSREDLDMSTSSRKSAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFFQMDVISPTTKNTQTTLEMEKAVDMTQSIISGAVSPSGDGVPQKRIDRQINEDVRKLMMGLFGCLEPELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQDTHSFLSMTFASALVQVKRSFDRFMQNQLLSIREAKLHKRSKAILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNAIFEGIQLHSQEHPKTPVQVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGRPLEKLNQFFEGVQLKVAQGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSEEENLLQVVWHAMQEEFIAQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.", "AFDB_id": "AF-Q9VVG4-F1-model_v4" }, { "swissprot_id": "C6BSL0", "sequence": "MPQNQSDIRRVFLHTGDAYLGVKPTIVSTVLGSCVAISMFSPRKRQGIICHAFLPSRAEIKDVNEPSIQICRYVDTAVDHLLKSMRRLGVRKNELEVKLFGGATGLSYSQVRPSCALGIGNRNVDAALENLEAKGLKPVSMDVGGNVGRKLLFCTYSGDVWIKRLEKHMF", "function": "Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.", "AFDB_id": "AF-C6BSL0-F1-model_v4" }, { "swissprot_id": "Q2KCH9", "sequence": "MIYSDAGIFLNETKASLVYSRLSKHIRNLGLSGFREYCELVASPAGAAARREMLSHLTTNFTRFFRENHHFEHLRDHVLPELLQRARSGGRVRIWSAASSDGQEPYSIALTVLSLMPNVADYDFKILATDIDPKILAIARAGAYDESALETVSPAMRKQWFSEVEVQGRRKFQVDDRVKRLITYNELNLMAQWPFKGKFDVIFCRNVVIYFDEPTQMKIWQRFAGLLPEGGHLYIGHSERVSGEAKHVFDNIGITTYRYTTKGLGRKA", "function": "Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.", "AFDB_id": "AF-Q2KCH9-F1-model_v4" }, { "swissprot_id": "P28829", "sequence": "MEYYTSKEVAEWLKSIGLEKYIEQFSQNNIEGRHLNHLTLPLLKDLGIENTAKGKQFLKQRDYLREFPRPCILRFIACNGQTRAVQSRGDYQKTLAIALKKFSLEDASKFIVCVSQSSRIKLITEEEFKQICFNSSSPERDRLIIVPKEKPCPSFEDLRRSWEIELAQPAALSSQSSLSPKLSSVLPTSTQKRSVRSNNAKPFESYQRPPSELINSRISDFFPDHQPKLLEKTISNSLRRNLSIRTSQGHNLGNFGQEILPRSSRRARPSELVCPLSSLRISVAEDVNRLPRIDRGFDPPLTVSSTQRISRPPSLQKSITMVGVEPLYQSNGNEKSSKYNVFSESAHGNHQVLSFSPGSSPSFIEQPSPISPTSTTSEDTNTLEEDTDDQSIKWIRGALIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRIGENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHPFVS", "function": "Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase.", "AFDB_id": "AF-P28829-F1-model_v4" }, { "swissprot_id": "Q9LR47", "sequence": "MREEKSKTNKLAWSKKMVRKWFNIKSKTEEFQADDPSSAGIEVEHRSSFSAEKAPSTIKNTKTEKLSKNWEQQARQRRMNYENPRIIDVQNYSIFVATWNVAGRSPPSDLNLDEWLHSSAPADIYVLGFQEIVPLNAGNVLGAEDNGPAQKWLSLIRKTLNNRPGTSGTSGYHTPSPIPVPMAELDADFSGSTRQKNSTFFHRRSFQTPSSTWNDPSIPQPGLDRRFSVCDRVFFSHRPSDFDPSFRGSSSSHRPSDYSRRPSDYSRRPSDYSRRPSDYSRRPSDSRPSDYSRPSDYYSRPSDYSRPSDFSRSSDDDNGLGDSPSTVLYSPGSAANENGYRIPWNSSQYCLVASKQMVGVFLTIWVKSELREHVKNMKVSCVGRGLMGYLGNKGSISISMLLHQTSFCFVCTHLTSGQKEGDELKRNSDVMEILKKTRFPRVKSSEEEKSPENILQHDRVIWLGDLNYRIALSYRSAKALVEMQNWRALLENDQLRIEQKRGHVFKGWNEGKIYFPPTYKYSRNSDRYSGDDLHPKEKRRTPAWCDRILWFGEGLHQLSYVRGESRFSDHRPVYGIFCAEVESAHNRIKRTTSYSASRVQAEELLPYSRGYTELSFF", "function": "Has phosphatase activity toward PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Required for the patterning of procambium and during the differentiation of vascular tissues. Acts before the acquisition of preprocambial identity. Seems to be also involved in the abscisic acid (ABA) signaling pathway. Acts redundantly with CVL1 for maintaining vascular continuity. Regulates phosphoinositide-dependent VAN3 localization.", "AFDB_id": "AF-Q9LR47-F1-model_v4" }, { "swissprot_id": "Q755Q4", "sequence": "MARPTNSAASDVIPPSSKTRMPKIKPFKTIRTTFLKKKNTIGNLVSKGTHSSQSGGHKDSYMGDVESLTLRSPQSRGSWVESIDSKKIHSLSNDRVTLFRYEHVRVTSYQSVRKKYRNSGDSRRGQERMESAVKGTDVLRRERASVIEPRGPLEIYQIITPISKEPSQKVTYLCLGRKEQIIKPILPKLRITMLTREGLQFSVLSFNPENSWKIEFLGALGDSAVPCNVILAFENAVKNICRYTSELNNDPIEEVGTEDDDDLEYLLYSDFAEDDDTGSDITLNREHSSEPSDLLNCSTTNEMINDAFRKAIEHIRHVGSMPLIEAHGVKSFSSQLKIDGEQVDPPPKASPRQRAVSVPVETRTWSKLSTHPVALSTWMDIEYDDIKE", "function": "Required for peroxisome inheritance.", "AFDB_id": "AF-Q755Q4-F1-model_v4" }, { "swissprot_id": "Q9KEJ2", "sequence": "MKPTETLQEKGKLFLVVMMPILITQIGLYAMNFFDTVMSGQAGANDLAGVAIGSSLWVPVFTGLNGVLLALTPIIAQSIGAEKRDDVPYVFLQGLYLSIAISIAVILIGAVVLDPILSAMSLEDEVGRIAKEYLIGLAFGIVPLFIYTTIRCLIDSLGETRVTMFITLLSLPINIFFNYVLIFGKLGFPRLGGVGAGYASAITYWFILAVAIVVVVKVRPFTDFQLFKKLYHVSLKKWKEILLLGLPIGFTIFFETSIFAAVTLLMSTFDTATIAAHQAAVNFASFLYMIPLSIAFTLTIAVGYEVGAKRVEDARQYSRLGITFALIMGLVAGVIIYVLRAPVASLYTNDSQVAWLIQQFLIYSIFFQLSDALATPIQGVLRGHKDVNVPFVMALVSFWIIGLPTGYLLANFSPLGPYGYWIGLITGLASCAIALSWRLKQMQRKFERAARLSQNGNS", "function": "Multidrug efflux pump.", "AFDB_id": "AF-Q9KEJ2-F1-model_v4" }, { "swissprot_id": "G5ECL4", "sequence": "MSSERRKDNPLRFALILHLLAVLVQGDIQPRFSCYNHYLAGIRTSSVLPISGHSSAPSNVKCIFENDVAFTEIHSALENSYQVMGKKSVNFQVLDLFHLRELVRRSHCTQTLTVTWKNVPEAGKGGLKVVSLLNETTRIEYSGDERQDFLFDETFAGVRHLIPDEDDNESNPTVTTTRLLCKHIPQPECLVRGKFEVDLEANLEWSYAFSFKTDITNQTLFTLRCGDTTSEVRLENDFFIRADGNAPVAVTHLSDATWHTAIVKHNQPDSHFLKIDDFPEIELGKSISDDTDKTITLSISVNGNIQLIDPTDTNDDCMYSFDKPQKRLQETVSTRTMCVGCGCPKLSGTFDGLSKCDEEDENSYNLRRDVDRLSFIHIDNAFDIDSNGAAIPAISTSFKSDSDVGLIFFGYWQNFHGKGRLQVYYHYDTISAVFCKHTDDEECSSCSIRSSEGFGKDQWIQTILWGGGDEIHLAVDSSVCRLQQLSNISLAEVYAIPQISGGAGLFIGGTWHEKKRRGLYKADAEQKYFENTREKAPVLRGCIKDVFVRGSKTDVSEMFEVQKQAMLNEPDDSNAFAVRKYCQSCIPACSEGTRCRSRAPLQDSAMICDCADELQFNTSEGTCNRERDTPVALSTAFLSENQIVLDIQNTKAILSKVWLKFALPKQINQAQRIVEFNSHRETLFNINLETDGTVNVQLHGQDTASRQLNLLDDRVHLLQLQRRTPMGTRHSAKKYDLYIDGFHTVVSDIGKLVLNNVSVTAAETEDEWSSVIVHDLGLSYEYDEHFAISHPSNVIHQVDLHSQLLPYQIRAPDLSKTGILDDSLWEKPAYVTDSEAAPVLESSPHGEVVDFTADIIEPEQLLSGRWILYSLFLTILLCLFILMCIVCYWCVLRPRAMRRTDTGSQRTIIRDSPDYAPVKMRRDSIGGISIDDDGSIGTDDTDLQAYRDIPSHRVKIYRESMVSILVPSIDQPAEAAIVKRSHSTISDQTPSRPHDTSHAPLVAVNDD", "function": "Maintains the normal guidance and termination of axonal branches of VC motorneurons. By associating with cell adhesion protein casy-1, mediates axonal interactions to establish synaptic connections between the male-specific sensory neuron HOA and the AVG interneuron. Plays a role in regulating male mating behavior.", "AFDB_id": "AF-G5ECL4-F1-model_v4" }, { "swissprot_id": "F4K1R2", "sequence": "MEARRLAILCSHLNPPGPNPTRDPTLRVSDCSSGSSGDGKVESSTLQNDCVFCKIIRGESPCLKLYEDDMCLCILDTNPLSHGHSLIIPKLHYPTLEETPPSVVAAMCSKVPLISNAIVKATGSDSFNLLVNNGAAAGQVIFHTHIHIIPRKERDCLWASESLRRHSLKLDKEASQLVSCVRRHLCSLPEEQLVQPS", "function": "Possesses adenylylsulfatase activity in vitro.", "AFDB_id": "AF-F4K1R2-F1-model_v4" }, { "swissprot_id": "Q30KJ4", "sequence": "MATRSVLLALVVLNLLFYVPPGRSGPNVYIQKIFASCWRLQGTCRPKCLKNETISYFGVILYICGCVNPKYLPILTGK", "function": "Has antibacterial activity.", "AFDB_id": "AF-Q30KJ4-F1-model_v4" }, { "swissprot_id": "Q04062", "sequence": "MFNNHEIDTILSTLRMEADPSLHPLFEQFEKFYEEKLWFQLSESLTKFFDDAKSTPLRLRLYDNFVSKFYDKINQLSVVKYLLASLKDSKDFDESLKYLDDLKAQFQELDSKKQRNNGSKDHGDGILLIDSEIARTYLLKNDLVKARDLLDDLEKTLDKKDSIPLRITNSFYSTNSQYFKFKNDFNSFYYTSLLYLSTLEPSTSITLAERQQLAYDLSISALLGDKIYNFGELLHHPIMETIVNDSNYDWLFQLLNALTVGDFDKFDSLIKVQISKIPILAQHESFLRQKICLMTLIETVFVKNIRMLSFEDISKATHLPKDNVEHLVMRAISLGLLKGSIDQVNELVTISWVQPRIISGDQITKMKDRLVEWNDQVEKLGKKMEARGQSIWV", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.", "AFDB_id": "AF-Q04062-F1-model_v4" }, { "swissprot_id": "Q6YYX9", "sequence": "MAIVDLVNAGEQQQMGSKRAAAEDGDGGVDDSREYYCRRGVRHLCDSGITRLPGNYVLPASDRPGQAAGAAAAAGGSVKLPVVDLSRLRVPSERGAVLRTLDAACREYGFFQVVNHGVGGEVVGGMLDVARRFFELPQPERERYMSADVRAPVRYGTSFNQVRDAVLCWRDFLKLACMPLAAVVESWPTSPADLREVASRYAEANQRVFMEVMEAALEALGVGGGGVMEDLAAGTQMMTVNCYPECPQPELTLGMPPHSDYGFLTLVLQDEVAGLQVMHAGEWLTVDPLPGSFVVNVGDHLEILSNGRYRSVLHRVKVNSRRLRVSVASFHSVAPERVVSPAPELIDDRHPRRYMDTDLATFLAYLASAAGNHKSFLHSRRLY", "function": "Involved in the regulation of shoot development and salicylic acid (SA) homeostasis.", "AFDB_id": "AF-Q6YYX9-F1-model_v4" }, { "swissprot_id": "P55995", "sequence": "MTEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKNNKSLVFIACQKDKLNDNEAPYYDVGVIGSVMREANMPNGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEYDKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDPNRIADLIAAALHLKKDQAYSLFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEYFLKEQLKQIQKELGTDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLDVPFGQYGKKALDIKHVREQLDKDHYSLKRPKERIVEYFATMQLLEMRRKKKPEKKDKTKGTILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVNELRGHRRTYIGSMPGRIVQGLIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNTAFRDHYANFSIDLSQVIFIATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECLKLIIEKYTREAGVRDLRRQIATIMRKVALKYLEDNPHQKGRTKKGKNEKSEDQKSEDQKSENQKSENKDFCVSITPNNLKEYLERMVFEIDPIDEENKIGIVNGLAWTPVGGDVLKIEVLKIRGKGELKLTGSLGDVMKESAIIAFSVVKVLLDNETLKVPKIPSETDAEGKKKKKVLKVYNAYDLHLHVPEGATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALIPVKNYERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL", "function": "ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.", "AFDB_id": "AF-P55995-F1-model_v4" }, { "swissprot_id": "Q60837", "sequence": "MDMMGLAGTSKHITFLLLCQLGASGPGDGCCVEKTSFPEGASGSPLGPRNLSCYRVSKTDYECSWQYDGPEDNVSHVLWCCFVPPNHTHTGQERCRYFSSGPDRTVQFWEQDGIPVLSKVNFWVESRLGNRTMKSQKISQYLYNWTKTTPPLGHIKVSQSHRQLRMDWNVSEEAGAEVQFRRRMPTTNWTLGDCGPQVNSGSGVLGDIRGSMSESCLCPSENMAQEIQIRRRRRLSSGAPGGPWSDWSMPVCVPPEVLPQAKIKFLVEPLNQGGRRRLTMQGQSPQLAVPEGCRGRPGAQVKKHLVLVRMLSCRCQAQTSKTVPLGKKLNLSGATYDLNVLAKTRFGRSTIQKWHLPAQELTETRALNVSVGGNMTSMQWAAQAPGTTYCLEWQPWFQHRNHTHCTLIVPEEEDPAKMVTHSWSSKPTLEQEECYRITVFASKNPKNPMLWATVLSSYYFGGNASRAGTPRHVSVRNQTGDSVSVEWTASQLSTCPGVLTQYVVRCEAEDGAWESEWLVPPTKTQVTLDGLRSRVMYKVQVRADTARLPGAWSHPQRFSFEVQISRLSIIFASLGSFASVLLVGSLGYIGLNRAAWHLCPPLPTPCGSTAVEFPGSQGKQAWQWCNPEDFPEVLYPRDALVVEMPGDRGDGTESPQAAPECALDTRRPLETQRQRQVQALSEARRLGLAREDCPRGDLAHVTLPLLLGGVTQGASVLDDLWRTHKTAEPGPPTLGQEA", "function": "Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.", "AFDB_id": "AF-Q60837-F1-model_v4" }, { "swissprot_id": "B6YR69", "sequence": "MRLSKFKFHLPQELIALFPSVDRDESRLMVVYHKTGRVEHVIFKDIIQYFNEKDTFIFNDTSVIPARLNGNKEKTGARVEVFLLRELDPIQRIWDVLVDPARKIRIGNKLYFENEDSDTIVAEIIDNTTSRGRIIRFLYDGPYESFKKILYNLGNMPIPDYLDRKVTKEDRERYQTIYAKNEGAVVAPAAGLHFSHELMKRLELKGCELTFITVHSGMGNFRAIDVEDLFKYKSESERIVINTETATKINQAKQNRKQICAVGTSVLRTIEDRENVVTSQGYLNPFTGWTNKFIFPPYNFITSTSLITGFHLPLSSMLLQVAAFGGFDLIMDVYKQAIEAKYRFGVYGDAMLII", "function": "Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).", "AFDB_id": "AF-B6YR69-F1-model_v4" }, { "swissprot_id": "Q9FRR1", "sequence": "MNQKPPPYGYGGAGGGGVGPSSTSNTTIIGTLSARAKQTTQSMITTLRPWREILDLSALSLPRGYDEAMAHLKHNISYFRGNYALAVLAIVFLGLIYHPMSMIAFIVVFIGWILLYFSRDANDSIVISGKEVDDKIVLVLLSLVTVLALVYTDVGENVLVSLIIGLLIVGAHGAFRNTDDLFLDEESARRGGLVSAGSGNRPPSSYTPI", "function": "May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.", "AFDB_id": "AF-Q9FRR1-F1-model_v4" }, { "swissprot_id": "Q8BMI4", "sequence": "MGVNDLWQILEPVKQHIHLQDLSGKTIAVDLSLWVCEAQTVKKMIGTVKKPHLRNLFFRISYLTQMNVKLVFVMEGEPPMLKADVISKRTQTRYGPSGKSRSQKTGRSHFKSVLRECLEMLECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPHVDCYTISSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQIFKGQSLLQRFNQWIEDPCYSVPQSAPKKVVHCSVCSHPGSPKDHERNGCILCKSDKYCEPHDYDYLCPCEWHQTDHNRHLSEIENNIKKKACSCEGFPFHEVIQEFLLNKNKMLKPITYQRPDLLLFQRFTVQKMEWPSHYACEKLLVLLTRYDMIERKHGRKTSNQLQPIRIVKPRVRNGVHCLEIEWEKPEHYVVEDGDPGKLSLLTMEEASLFEAAYPDAVAVYQKQLSETKGRKQKSMKNKPKGSHLPEADDVINSQSLMTLKPTSKAFPKQNPKINLENSPDPILAQESTSPSLNSFVSPENAPCLNLQEQLVPSPRTLAIKQSKDVSHFLVSECSQPSSSSHDISVITDLQLSTIDWAGTSFSNSPAVQRNTFSQDLASESESSAILPDFEQLSYESEQGTSDSEGSGRDLQQSNPEEQLLSGISALHLHDLPLKERIRIKSSCPQYNVGADAGLESLPLKLKGSCIAYSSSDGSSNFSKDLTGVYLHKESRNSKVLDSRLQENCGANTSLPYSFSDKAVKTSSLQVGLPTAAIPHNPRVAVKTTKNLVMKNSVCLERDSSDEDNAPGSWKSKYTAPEMKHSSQKHSLVHVRDSTHNKLRNPKVESKETKLCNESFKTAEDEENGFSDLGRSPQSFRPCHDKDENSTASWENPLPLRQRLKLRFQNTQSGFYNT", "function": "Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction. Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA. Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates.", "AFDB_id": "AF-Q8BMI4-F1-model_v4" }, { "swissprot_id": "P39678", "sequence": "MSNQIYSARYSGVDVYEFIHSTGSIMKRKKDDWVNATHILKAANFAKAKRTRILEKEVLKETHEKVQGGFGKYQGTWVPLNIAKQLAEKFSVYDQLKPLFDFTQTDGSASPPPAPKHHHASKVDRKKAIRSASTSAIMETKRNNKKAEENQFQSSKILGNPTAAPRKRGRPVGSTRGSRRKLGVNLQRSQSDMGFPRPAIPNSSISTTQLPSIRSTMGPQSPTLGILEEERHDSRQQQPQQNNSAQFKEIDLEDGLSSDVEPSQQLQQVFNQNTGFVPQQQSSLIQTQQTESMATSVSSSPSLPTSPGDFADSNPFEERFPGGGTSPIISMIPRYPVTSRPQTSDINDKVNKYLSKLVDYFISNEMKSNKSLPQVLLHPPPHSAPYIDAPIDPELHTAFHWACSMGNLPIAEALYEAGTSIRSTNSQGQTPLMRSSLFHNSYTRRTFPRIFQLLHETVFDIDSQSQTVIHHIVKRKSTTPSAVYYLDVVLSKIKDFSPQYRIELLLNTQDKNGDTALHIASKNGDVVFFNTLVKMGALTTISNKEGLTANEIMNQQYEQMMIQNGTNQHVNSSNTDLNIHVNTNNIETKNDVNSMVIMSPVSPSDYITYPSQIATNISRNIPNVVNSMKQMASIYNDLHEQHDNEIKSLQKTLKSISKTKIQVSLKTLEVLKESSKDENGEAQTNDDFEILSRLQEQNTKKLRKRLIRYKRLIKQKLEYRQTVLLNKLIEDETQATTNNTVEKDNNTLERLELAQELTMLQLQRKNKLSSLVKKFEDNAKIHKYRRIIREGTEMNIEEVDSSLDVILQTLIANNNKNKGAEQIITISNANSHA", "function": "Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.", "AFDB_id": "AF-P39678-F1-model_v4" }, { "swissprot_id": "Q8EQ23", "sequence": "MPTPSMEDYIEIIYNLIESKGYARVSAIAEALDVHPSSVTKMVQKLDKDQYLDYEKYRGFVLTSKGKKIGERLVFRHELLEEFLEIIGVNDENIYDDVEGIEHHLSWNSIDRIGDLVNYFKDDDSRVKDLKKVIKESDQQVNETAEK", "function": "Central regulator of manganese homeostasis.", "AFDB_id": "AF-Q8EQ23-F1-model_v4" }, { "swissprot_id": "Q00538", "sequence": "MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMKNTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAASINGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPFIGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFLSYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQFIGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEAGQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAGQRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLVWLFLAAHNGTAASEKM", "function": "Resistance to the epoxide antibiotic methylenomycin.", "AFDB_id": "AF-Q00538-F1-model_v4" }, { "swissprot_id": "Q9Z4S6", "sequence": "MANLTRRQWLKVGLAVGGMVTFGLSYRDVAKRAIDGLLNGTSGKVTRDRIFGNALIPEAQAQTHWQQNPQQTIAMTQCFGCWTQCGIRARVNADGKVIRIAGNPYHPLSQEHPIDSSVPFSEAMEQLAGESGLDARSTACARGATLLESLYSPLRLLEPMKRVGKRGEGKWQRISFEQLIEEVVEGGDLFGEGHVDGLRAIHAPDTPIDAKHPSFGPKTNQLLVTNTSDEGRDAFLRRFALNSFGSKNFGAHGAYCGLAYRAGSGALMGDLDKNPHVKPDWENVEFALFMGTSPAQSGNPFKRQARQLASARLRENFQYVVVAPALPLSTVLADPRGRWQPVMPGSDSALAMGMIRWIMDNQRYNADYLAIPGVQAMQQAGEQSWTNATHLVIADELPTLAGQHLTLRHLTPDGEETPVVLNTDGELVDASTCRQARLFVTQYVTLADGQRVTVKSGLQRLKEAAEKLSLAQYSEQCGVPEAQIIALAETFTSHGRKAAVISHGGMMAGNGFYNAWSVMMLNALIGNLSLSGGVFVGGGKFNGVSDGPRYNMNSFAGKVKPSGLSIARSKTAYEASEEYRDKIAGGQSPYPAKAPWYPFVAGQLTELLTSALEGYPYPLKAWISNMSNPFYGVPGLRAVAEEKLKDPRRLPLFIAIDAFMNETTALADYIVPDTHNFESWGFTAPWGGVASKATTARWPVVAPATHRTADGQPVSMEAFCIAVAKRLHLPGFGDRAITDPQGNTFPLNRAEDFYLRVAANIAFMGKTPVALANQEDISLTGVSRILPAIQHTLKADEVGRVAFIYSRGGRFAPEDSGYTEQRLGNAWKKPLQIWNADVAAHRHAITGERFSGCPVWYPARLSDGRAIDDQFPIGQWPLKLISFKSNTMSSSTAVIPRLHHVKPANLVALNPQDGERYGLQHGDRVRIITPGGQVVAQISLLNGVMPGVIAIEHGYGHREMGATQHSLDGVPMPYDPQIRAGINLNDLGFADPTRTITNTWLDWVSGAAVRQGLPAKIERI", "function": "Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrA is the catalytic subunit. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.", "AFDB_id": "AF-Q9Z4S6-F1-model_v4" }, { "swissprot_id": "P95442", "sequence": "MTTTLYTGFHQLVTGDVAGTVLNGVDILVRDGEIIGLGPDLPRTLAPIGVGQEQGVEVVNCRGLTAYPGLINTHHHFFQAFVRNLAPLDWTQLDVLAWLRKIYPVFALVDEDCIYHSTVVSMAELIKHGCTTAFDHQYNYSRRGGPFLVDRQFDAANLLGLRFHAGRGCITLPMAEGSTIPDAMRESTDTFLADCERLVSRFHDPRPFAMQRVVVAPSSPVIAYPETFVESARLARHLGVSLHTHLGEGETPAMVARFGERSLDWCENRGFVGPDVWLAHGWEFTAADIARLAATGTGVAHCPAPVFLVGAEVTDIPAMAAAGVRVGFGVDGHASNDSSNLAECIRLAYLLQCLKASERQHPVPAPYDFLRMATQGGADCLNRPDLGALAVGRAADFFAVDLNRIEYIGANHDPRSLPAKVGFSGPVDMTVINGKVVWRNGEFPGLDEMELARAADGVFRRVIYGDPLVAALRRGTGVTPC", "function": "Catalyzes the deamination reaction of hydroxyatrazine to N-isopropylammelide (dihydroxy-isopropyl-atrazine). The enzyme is also capable of catalyzing some dechlorinating reactions.", "AFDB_id": "AF-P95442-F1-model_v4" }, { "swissprot_id": "Q2N9C8", "sequence": "MMADEKKTPENEAETATPAVAVEDALKAEPTETLEAQKAKAEAETPAVAETPSEAAANQSAAQGAEGQPRERGGHDRGGRGGRGGNDRGRGRGGRDNRRGGRREEEDDGIIEKLVHINRVSKTVKGGKRFGFAALVVVGDGQGRVGFGKGKAREVPEAIQKATAAARKKMIRVALKEGRTLHHDGNGRFGAGKVTVRTAPPGTGIIAGGPMRAVFESLGVADVVTKSVGTSNPYNMIRATFDALQDQTSPKSVAQRRGKKVADLLGRGGASEAEAEADAAAIAE", "function": "Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.", "AFDB_id": "AF-Q2N9C8-F1-model_v4" }, { "swissprot_id": "Q9PGG2", "sequence": "MNALQWSFRAQCLTGFLFCTGLLAYAIFLQLHQGLEPCPLCIFQRIAFAVLGILFLIAGLYNSSNVYTRKAYGLLIFLTAAIGTGIAGRHVWVQLMPHNTISSCGSPLSFLSETMGPFEVFRTVLTGTSDCGNIDWRFLGLSMPMWSMFWFVALALLGLLVGFKAERRKPLFS", "function": "Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.", "AFDB_id": "AF-Q9PGG2-F1-model_v4" }, { "swissprot_id": "B1A0U6", "sequence": "MVLLYILIMVALIPMYMTVVQDATFSHPPPGLLIPEAWSGSGSIRLWTDAQEIPVRCFWKLVYDPRIHPETAAIQQGDSIMYMYSGTRFLDYRTVLSALLLTFVFFWRMLSMFDRSRNRFQRACVSIPSALLEVCRQKAIKKTATLPFYGQALYFGIMCLYTAHIVLWDFLNSFAGTLWLITLNLANGTAQIINLRKERHRNRHDEESSWTFGQIVPIVLLVSPLVAAFEDLLSKRSRRALREGSVGNTSLNEVDLTPEPSLTEATTLSLHTRPLIYSVPTSITQSSIASQKSSGTPAQDLIRSSWPYAILFWELHVLLAFMVIWLPLAQSQLFIFRYAYWEAYYAFPAAVGTFWLTVVIAVPFSSIGRSSYPCPKPRRSGLNVA", "function": "Part of the gene cluster that mediates the biosynthesis of elsinochromes, pigments consisting of at least four interconvertible tautomers (A, B, C and D) that have a core phenolic quinone to which various side chains are attached and which play an important role in fungal pathogenesis. The non-reducing polyketide synthase PKS1 was proposed to iteratively catalyze decarboxylation between acetyl-CoA and malonyl-CoA subunits for polyketide chain elongation. The released polyketide undergoes cyclization to form an aromatic ring, and proceeds via serial modification steps to produce the heptaketide back- bone of elsinochrome. As elsinochrome has a symmetrical structure, two identical heptaketides are fused to form a core 1,2-dihydrobenzo-perylene ring structure, which can then be successively modified to produce the various derivatives of elsinochrome. Some of these reactions may be cooperatively carried out, at least in part, by the products of RDT1, OXR1 and PKS1. PRF1, embedded within the elsinochrome cluster possibly functions to stabilize some of the biosynthetic enzymes required for elsinochrome production. As prefoldin is a hexamer containing 2 a and 4 b subunits, additional prefoldin subunits, whose coding genes may not immediately link to the elsinochrome biosynthetic gene cluster, are required to fulfill the chaperone function. In addition, no methyltransferase-coding gene exists within the biosynthetic gene cluster, even though elsinochrome has four methyl groups at positions C3, C7, C8 and C12. Apparently, the identified gene cluster does not contain the entire entourage of genes responsible for elsinochrome biosynthesis. Once elsinochrome is synthesized, it must be exported outside the fungal cells, which is probably accomplished by the ECT1 transporter, to avoid toxicity.", "AFDB_id": "AF-B1A0U6-F1-model_v4" }, { "swissprot_id": "P9WMQ2", "sequence": "MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEMLLITFNRAASRELRERVRGQIVEAVGALQGDAPPSGELVEHLLRGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADVELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALALALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATALEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPKQAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATLGHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEALRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNALAEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFGETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRRVLSQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAGPPEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHDDGTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRAQSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTPRVTDEQAWAVFAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSYSDLVRGSEAVTVTSEPAAGGRADEVEIAVVAAPGSGADLTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVRRHAPWWTVDVDHAQLAPELARALLPMHDTPLGPAAAALTLRQIGVRDRLRELDFEMPLAGGDLRGRSPDVSLADVGELLASHLPGDDPLSPYADRLGSAGLGDQPLRGYLAGSIDVVLRLPGQRYLVVDYKTNHLGDTAADYGFERLTEAMLHSDYPLQALLYVVVLHRFLRWRQRDYAPARHLGGVLYLFVRGMCGAATPVTAGHPAGVFTWNPPTALVVALSDLLDRGRLQS", "function": "A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.", "AFDB_id": "AF-P9WMQ2-F1-model_v4" }, { "swissprot_id": "Q5RG44", "sequence": "MSQENVSDKVRNIQKQIGHNIKFGQRPPSLRKSEGDEGSSDEEEVPQSPLRVLAQVENEPPETSAKEKSVSHDTVQHRTPVKSPRTKRPPPPGTIESINLDAVPQSVPRLDNTAAKHKLSVKPKNQRVSRKHRRFTQEFHEDDFSEIQEEFEKDEEVFDSSREDYGIIHGSKEDYEPTEKSQRQRFHEEEKEHLEIKKREQEEERKMEKHRRMIEEQRLEEEKRRRQEEERLQKVEEERKQREEEERKKREEEERRREEEERRLRHEEERKRQEEEERMKKEEEERKRAEEERRQQELLAERLRLEEERKREQEERRRKEEEEAEKRRIQELQEKRLREEEHRIREEERCRQEEAERKRLEEEERKRQLQEEKAGSTDPEWKRKAEELRWREMEERQRPFTFKVSSGEKQILFQKVNLTPVTPATGQQGETTAETWEGAKASSPGGPDSPTLSSSLYVPHTAILVTGAQLCGTAVNLDQIKDTACKSLLGLSEGKKAMGTPPSKSKTSPDRKSGKTKSVFESSLSTDQSNAAVLAEWASIRSKIFKGAEEGKYPEYTDQSRRPTSEDLNTVPFSHTNLRKTMSASAKFSITPARKKFADSNRNSEIFGQEEGVKTESAFTETSPVQKELPSLGTKVQSRGSKLVRIADEECMFAKDLPSFLVPSPPHGSPKSQRSESGSPIQAESEDSDTKDEDGEQKAQGGDEQPSPFGIKLRRTNYSLRFHNEQSAEKKKKRYSAGDSFEGVPVPLTAIDQDSDNSTLSEKSSPISPQQENIEFQTTVAPSKESRSKFSRSTLPLARTEGDNMSPKPPLYQKPATSPKPSEGATPLLSPLPKPGRRTSGDTISQRTGEAEQVATEQGSDHKGGVTASGPSQKSGQGEEDVKEKKSFFPSISIPWREKTDRRTELIKKEKPSLQARHSLDSSRSQDKETGPLWITLALQKQKGFREQQQNREERRNQREAKLAEKQARDRESAGSSPTEDKGNGSSSIISKHQTADENKRPDTLLARFERRDNLKKANTLPSSVTVEITDSTPSPPATKDVTKRFPPGDTTQVSTEPAWLALAKRKAKAWSDCPQIIK", "function": "Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin.", "AFDB_id": "AF-Q5RG44-F1-model_v4" }, { "swissprot_id": "Q86B14", "sequence": "MIYTDAGVDEDKATIRPNQTHQFQKVQDEAKEWTKNKFLEFLNNFKLKKKIDKNNNNNNNEDNEDNNENENEYDENGIKKEKIDKSYYRQQVERMIKNDKSSLYIDFLHLEKFDKGLGKALLMEYFRLEPAIRQGLSIFIQKYFPSFMERVNKERIVLSICCYNVSTFVHIRELRSSRIGSLCSISGTVTRTSEVRPELVIGSFICKDCNTSSLPIAQQFKYTEPTKCLNPLCSNQRRWKINLEESTFTDWQKVRVQENNSEIPGGSVPRSLEIILRGDSVETARAGDTCTFVGTMNVIPDVSKMSIGNNAQIIKGVASSTKEGSNANGKDDFGGVGGLKDLGVREMNYRVCFFSQSVRSNVSTLSSINRKESGDNHGGHSHSVGIIDEDLEPESKESFLDSLPKKEKDSLKKMIKSKKIYQNLVNSICPSIFGHEEIKRGVLLMLFGGVHKKTPEKIRLRGDINVCIVGDPSTSKSTFLKYLVSFLPRTVYTSGKASSAAGLTATVVKDQESGDFNIEAGALMLADNGICCIDEFDKMEPGDQVAIHEAMEQQTISIAKAGIHASLNARTSILAAANPIGGRYDRNKTLKQNLNIGGPLMSRFDLFFVVLDECNPESDHRIAEHIVLTHQKREKAFNAPFSATEIKNYIKYTKFICPTIPDESVQLLVGHYDRLRQMDTSGSKTPAYRITVRQLESLVRLSESLARLHLDTKVLPKYVNEAARLLEKSIVHVETNDVILGDDDDDLVKNVENDNDNHAEEDGDDGIGKLTMNFSKYSQLSKLLVLQIKQSGKEKSGIKQIDLIDWYIKDQLESGIITDDEVTKETKITKMVINKMINKDNSLVVLVPNQYPDHRILIIHPNYSFDK", "function": "Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.", "AFDB_id": "AF-Q86B14-F1-model_v4" }, { "swissprot_id": "Q9LK18", "sequence": "MVQLLFKFLIQVGATFVELSRNEIGNKNLLLLIHHAGSLLLSMFGSFSNYPVQKFLDMLDERCLTLIASEFDSYFENLVKDRVGNYVVQRLIWGFKRTGIDLPHSLTSVLVTRSIHLCKHRYGYQVIEAFDRSTRLA", "function": "Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.", "AFDB_id": "AF-Q9LK18-F1-model_v4" }, { "swissprot_id": "Q6F5E2", "sequence": "MIKHSLSDCLADPDHLIRIKSYVEANVRFLGLSLVTLLVTIQMFRALGSPLRLNKPLVGRRSILEPRWLVGLRFTKGGRELLRQAYKKYKDEIFKVQCNDTEICVLPHRYVEELRGLPASKVSSPQALYNKGLGSYTGLEVIVESHLHFQAIQGHLTPNLASALGIVLDELQDALKTVLPDCSDEWVPFDVHTVLSELVSRLSSRVFGGLELARNQQWIQLSTAYPRNAFACTMALRMVPRIIRPLLAAVLPTYWRTRSNIRDAKRIVGGIITKRRADEGATDMSAKEHPCDLLQWMMNAAAGTETHADDLAHRLLFISDASVMTTSLLISHCLYDLVAHPEALSCIREEVHNVLREGDNFQKTTLHKMRSLDSALKESQRLNPPFLMTFDRVVREPLLLSDGTQIPVGTHLAMPTDAMLQDSSLLPQGGVAPDQFDPFRYARAREDPENAQRFQLATTEAKSLVFGHGKHACPGRFFASSEAKIILSHLLLLYDFRYPEGKGRPESWLFSENVAIDPNARLLIKKRNDAASNLAMLAKAL", "function": "Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of aphidicolin, a specific inhibitor of eukaryotic DNA synthesis and DNA polymerase alpha. The geranylgeranyl pyrophosphate synthase GGS is required for supplying a sufficient amount of geranylgeranyl diphosphate (GGDP), the general precursor of diterpenes. The diterpene synthase ACS then catalyzes the conversion of geranylgeranyl diphosphate to aphidicolan-16-beta-ol via the intermediate syn-copalyldiphosphate (syn-CDP). In addition to aphidicolan-16-beta-ol, the enzyme produces also low levels of amphidicol-15-ene and amphidicol-16-ene. The cytochrome P450 monooxygenase P450-2 then catalyzes the two-step hydroxylation from aphidicolan-16-beta-ol to 3-deoxyaphidicolin via a 17,3-deoxyaphidicolin intermediate. Finally, the cytochrome P450 monooxygenase P450-1 converts 3-deoxyaphidicolin to aphidicolin.", "AFDB_id": "AF-Q6F5E2-F1-model_v4" }, { "swissprot_id": "Q89ZX0", "sequence": "MRTFLSLKTCLLSALLLCVNSIAASKIISVSDFGLKPDSRINAVPFIQKAIDACKQHPGSTLVFPKGRYDFWAQHAIEKDYYETNTYDVNPKILAVLLEQINDLTIDGNGSEFIMHGRMQPFTLDHCRNITLKNFSVDWEIPLTAQGIVTQSTSEYLEIEIDSHQYPYIIENKRLTFVGEGWKSSLWAIMQFDPDTHLVLPNTGDNLGWRSYDATEINPGLIRLSDPKKEADKFFPAPGTVLVLRHSTRDHAGIFIYHSMDTKLENVKLFHTCGLGILSQYSKNISFNDVHIIPNTSKKRVLSGHDDGFHFMGCSGLLKIENCSWAGLMDDPINIHGTCSRIMEVLSPTRIKCKFMQDMSEGMEWGRPDETIGFIEHKTMRTVATGKMNKFEALNKAEFIIELSVPLPAGVEAGYVIENLTCTPDAEIRNCHFGSCRARGLLVSTPGKVIIENNVFESSGSAILIAGDANAWYESGAVKDVLIRNNDFRYPCNSSIYQFCEAVISIDPEIPTPEQKYPYHRNIRIMDNTFHLFDYPILFARSVNGLTFSSNTLIRDTTYQPYHYRKEGITLEACKSVVISNNKIEGDVLGRIVTIEKMKPSDVKISKNPFFKLKK", "function": "Alpha-galactosidase. Removes both branched alpha-1,3-linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures.", "AFDB_id": "AF-Q89ZX0-F1-model_v4" }, { "swissprot_id": "Q9VPH0", "sequence": "MRKSPASLPSEAFSSSNSSLSNSYSDGSDLANWEEYVSTDGSLFYMEYVRCEKTGVSAERRVEFMRRSLRLGKKSSRRQPHSNNQNQSQNQNQSHGPSRLDSQTEPQEFRFSQFKTAAPDPKKLDLVITAADRFRFGRRSTAVESILGFRVLPFPDQPECLMVDGFVHDVSALQHGIKRGDWFRSLNGIEVYASNVDELLKQFVEPTQVCLGFQSCGAASAVSPTDPGYNRNVREEQVCKVENFPMFTEKFEQMLITEGNFGIPGSSVDIRMPFAMLLLPPECYQHEQQQDSLYYFPEIPDNFLFKARGSFLTLHAVLSELHTQPLSSRLLVDQVQYHVNYRQLNGFLVLFAYAGGLCCAAECSLRSDELIGYIRFSLPGLVLESFNQEREPGNSSRLKLFLRHFCEIQRTRLVARCHGHIRFEELLGQSRSLPLPKEAQLRIFDALSEMEAMDYRNWNDEPLTTHREFFIYGSALYYDGFLVASLLPPEVRVSVEGFLRCRGIFELLGAAPGIKVREMYVWEEIVLPSATGRYFLTICTKNHLSLAVILKIFDAPDMAPDAVVGPSLFYIEEIQETLDHLVQCGIESLAMFWSVSNKRPEVLDATASESRDQEKEPNNRLESFLKQKLTVLSPSVEEEAQLCSSLGGSSIHSLTPSEDESCRRRLTPIHGTAEDSDSGSDWENFAVQHPLHYGLNLGAESHSQSQMTESMWKEINNVVPVKISAGWKNSVLHYVYIDIANGSLFAPFTDSSENSNYLSEIRQACHIIHAVLQKSKHYRRHLSESSRAQTNSNGHSSHTVSLVKEHGMILEVSTQPKSDGQSQSSTSSRFVVVGRLFQSPAKEVYVCHRSDVPQNIVEMAFRLSFFSMG", "function": "Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Acts downstream of fuz and accumulates asymmetrically in wing cells to regulate planar polarity in the wing. Probably acts by regulating ciliogenesis.", "AFDB_id": "AF-Q9VPH0-F1-model_v4" }, { "swissprot_id": "Q6FIT9", "sequence": "MSFSSLLPPPEHSPPDDVNSREVEIITKEHDFIVNALTKKEAVHSSNNNIGSFVGSQVANFNDVIPLRQKDFYGVQAPLPTTQEIELCKVRTQEVVNRLLHKFTDKGKAGYQKDTRKITTGSRIITIESKRQDPLQPSRQKNTSSKIVLPEDDETDTPILHATDDAKSKRLTKEERAKWNIPAAVSSWKNPMGYTVGLKHRAAHGKKTGNVGSINNKVSDIVAALDETDQEIREGIQQENELKRKQLKEEERIKEEKLRAIAERSKIQTQSSAVKKRGSRFEGGRHQNKKIKKEEPPIKSAAERLKELAYAQGREVSEKVILGAAKATTTGTGANVHYDSRLFSKGANAAAKRSEEQVYDNPLFVQQEIDSIYRVNAKSIDEANSVSASRYGPIQFTKAHSLDDKSTAKDEEET", "function": "Involved in pre-mRNA splicing.", "AFDB_id": "AF-Q6FIT9-F1-model_v4" }, { "swissprot_id": "Q2M2T3", "sequence": "MAAVVALCRKAMETVKTKEFRDYLASTHFWGPVANWGLPLAAFRDMRASPDIISGRMTTALIFYSMAFMRFAYRVQPRNLLLMACHGTNIVAQSMQAGRYLNYHYGGGTTAATTAAVSAASATSTGSVDSSATSTGSVDSSATSTGSVDSSAATTPAAEDPVAHSNCQEITCCYLVTWDCD", "function": "May mediate the uptake of pyruvate into mitochondria.", "AFDB_id": "AF-Q2M2T3-F1-model_v4" }, { "swissprot_id": "P30641", "sequence": "METEIPVNEKETSFRRRVYTTIETLIDIENTDQLQEHLPHLHCLGWDEVVEERYVNKQCGFPSCQKAPPKITRNQMFEIDRKEGKIFEFRKQRAKFCSEMCYQKSSFVRKQLDEHPLWITGLTEARTQKVYEVPDESFVSPIAEKSEPVDSQFKKEPSIWLVTDSIIAKVQDMKLSEEAEEPKSLDPEDQDIEPFKLTDDDKDFIKSIKEFRNSNFGPPSTSKLLKTAPKPVLSAKDRKKEDEVLAKLRAKYGNKNALQKKPPILIEAQEIHSKLKTMEKAKEAWLVDLIKSWFTPETRKLVREGARPTGGAAEQILMDFLSGKKVDAEKLVNLPNLDKYNVKEKRLNIFLHSIRNHWMDLEARLHLTPTRRDILSRVASTFQLDSENITGWTKREINSIVIALFIVICLVDVELGDDYFKKDNASPELTAISNELCGLDSFQITGLHAAIKSQC", "function": "Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.", "AFDB_id": "AF-P30641-F1-model_v4" }, { "swissprot_id": "Q45695", "sequence": "MRQAIMSYQNLVSEAGLTQKHLIYGDKELFQHELKTIFARNWLFLTHDSLIPSPGDYVKAKMGVDEVIVSRQNDGSVRAFLNVCRHRGKTIVDAEAGNAKGFVCGYHGWGYGSNGELQSVPFEKELYGDAIKKKCLGLKEVPRIESFHGFIYGCFDAEAPPLIDYLGDVAWYLEPTFKHSGGLELVGPPAKVVVKGNWKVFAENFVGDIYHIGWTHASILRAGQAIFAPLAGNAMLPPEGTGLQATTKYGSGIGVSLDAYSGVQSADLVPEMMAFGGAKQEKLAKEIGDVRARIYRSQVNGTVFPNNCFLTGAGVFKVFNPIDENTTEAWTYAIVEKDMPEDLKRRLADAAQRSTGPAGYWESDDNDNMVLSQNAKKYQSSNSDLIADLGFGKDVYGDECYPGVVSKSAFSETNHRGFYRAYQAHISSSNWAEFENTSRNWHTELTKTTDR", "function": "Component of the 2,4-dinitrotoluene dioxygenase (DNTDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into 2,4-dinitrotoluene (DNT) to form 4-methyl-5-nitrocatechol (MNC) and nitrite. The alpha subunit has a catalytic role in the holoenzyme. Also able to convert naphthalene to cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene.", "AFDB_id": "AF-Q45695-F1-model_v4" }, { "swissprot_id": "P49756", "sequence": "MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK", "function": "RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.", "AFDB_id": "AF-P49756-F1-model_v4" }, { "swissprot_id": "Q9X6V6", "sequence": "MSKRVRSSLILPAVCGLGLAAVLLSSCSSKAPQQPARQAGISGPGDYSRPHRDGAPWWDVDVSRIPDAVPMPHNGSVKANPYTVLGKTYYPMNDARAYRMVGTASWYGTKFHGQATANGETYDLYGMTAAHKTLPLPSYVRVTNLDNGKSVIVRVNDRGPFYSDRVIDLSFAAAKKLGYAETGTARVKVEGIDPVQWWAQRGRPAPMVLAQPKQAVAQAAPAAAQTQAVAMAQPIETYTPPPAQHAAAVLPVQIDSKKNASLPADGLYLQVGAFANPDAAELLKAKLSGVTAAPVFISSVVRNQQILHRVRLGPIGSADEVSRTQDSIRVANLGQPTLVRPD", "function": "Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.", "AFDB_id": "AF-Q9X6V6-F1-model_v4" }, { "swissprot_id": "Q01359", "sequence": "MASFFRTAVRGPSAGLFRAVARPQPIAARVSLFSTSSRFRSEHHEETFEEFTARYEKEFDAVQDVFELQRNLNNAFAYDLVPSPSVLAAALKAARRVNDFPTAVRVFEGIKAKVENKGQYEQYLAELKPLREELGITLKEDLYPEEAN", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.", "AFDB_id": "AF-Q01359-F1-model_v4" }, { "swissprot_id": "P25992", "sequence": "MSKGGEHKRVTLTSIIQGDAGFSRFGSNILEPDAASAAPDNSSKPTTKTAKCIRIKLDLFETDSNKYPEFNYSRLLYLEKKKTKKLKQVSTTNGSASTDPFADNDDDVARIVKELEAKYGNSYATGRGKSKKDDYRDIGMGYDESDSFIDNTEAYDEIIPEEAETLEGGFYINCGALEFKNLTKKSYTTRTDAIIKMPERSRKRMVSSSSESSSSSSGDDDENDDGNNEEDDESDSEDDSEENDESDSEDDSESESLEDEDSAATAKSSSKYKDNHQAKRAKVIVTGKSKPSSSSLTSGKKPPTKPITTSSSSNSPRPSTVEISDTEDGQDPIQTQPSSQLQSLPQSQAQAQALKKVVKTTTVKDMLKAKRDSFLKSQSGTAAVKGVGNGELKCVSTDVSSSDSSDMESEHGRADRQAGQHGKDGQENLRTADTLLPTTLDADIVTAVNSFKEAVKSRDMCGKKFNLDVKLSPLLLRVYEAVLCTDRNERNMVFSHIEYQLQLPKYYMLRKGKQVRAKEEKRKSTIMLEKLRRAVAVVMPKAVANYETELRTFAEQAAADVNSELPPKMPRKKFQWTSELRHLLYDVYQARWTSYAFLAKRKESLEEFINWYLKEKVVELWPPGWMRLDELQREITRYKNAKLKAKEKPKAPPASASPKPVGVVSAPEQMPPASSYLKAVEDPRSRGNSDTDSATSASSNSLKRKLKEMPKQTSKPPKKKVAKQVPLQPQLTPHPQFQLAPAATAAVSIPAISNNNNHLPHLDTLLSMPSTSAQAAALNAAAVAAASTVLDLASPSRKIDLNTSNNFYNLITAASLAASGNPSPHSGDGQAKVIVGARPSPHVINLDDYQCTSDILQTSKQLAATTTVITAISKAAQTTSVARESSSESDGVEIVGVFPASKPQKKVQSKPKNKTQNRGRSSLGAVGQVNGSLGYSANNMYIYNSPRTLGPVYDLTDPHIMKTMSNLKEMEKQFIQAAFSPNSVKGASGGMGSSAPSTPTRQ", "function": "May play a key role in egg organization. May be a transcriptional regulator having a role in chromatin remodeling in concert with Hira, a histone chaperone. Involved in chromosome segregation by affecting kinetochores function in the first meiotic division.", "AFDB_id": "AF-P25992-F1-model_v4" }, { "swissprot_id": "P07383", "sequence": "EIIPVPDQAAWNASKKSIQINDAIKMRYVEWGNPSGDPVLLLHGYTDTSRAFSSLAPFLSKDKRYLALDLRGHGGTSIPKCCYYVSDFAEDVSDFIDKMGLHNTTVIGHSMGSMTAGVLASIHPDKVSRLVLISTALKTGPVLEWVYDTVLQKDFPLDDPSEFAKEWVAAPGKHDNGMAKNLKTEELAVPKHVWLSAARGFSIINWTAASKYLTAKTLILWGNQNQPMTESMQNDIRAALPKAKFIQYNGFGHSMFWEDPEMVAKDLNEFLK", "function": "Alkaloid degradation.", "AFDB_id": "AF-P07383-F1-model_v4" }, { "swissprot_id": "O94687", "sequence": "MEKGIKKYLPSLPFLACISDFPENHGTSRRSATVSLERVHELFTEHWLSNLKNRREKRQELAEEAVYCRSEMLSQRKLLAAVDFPQQLKNSPAKAKATHTSSGVTKEVRASKKYTSSNVEFPLVTDGKEKPVKSKQLRKNSVTEFEKPIETKKSKHRKSRNKFLDKSSGSMEIESWDNSTSDSIIESSSRLHESISLRENDIRSSDSKSVGWDDNSTGFRESSKSLDHTDTSMFMELDSNSDPQFRPKYQAKSSWFAPDDPEASWGNLDDGWGETNGSWSSTDDTKHYKNEWAESINLDNFNRPSQQEDYDKPKNTQVSRSSNHHRRYDSYHPDSRSDSYRSKREHYDNRDTGPRSKHLEKSSYVYNQNFEDRTHLSDHGAHFHLGNANDFNMQGSSRKRKASDRQRESRENELPTKKLNASDSHNPLASLTTDKNDLYINWLKSLSFFQTNSSCAEALVKVIPHYHNKLIDFSQVLQLVFSASEKFPIQENQPLPEQLMFLSNLEKQTPFAKAVGSSIYKLVTGKNLSLDFASQILKEASILEHKNEK", "function": "Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.", "AFDB_id": "AF-O94687-F1-model_v4" }, { "swissprot_id": "Q47953", "sequence": "MRSKTITFPVLKLTGQSQALTNDMHKNADHTVPGLTVATGHLIAEALQMRLQGLNELALILKHAHWNVVGPQFIAVHEMLDSQVDEVRDFIDEIAERMATLGVAPNGLSGNLVETRQSPEYPLGRATAQDHLKLIDLYYSHNIEAHRVVLEHNGHLDPISEDLLVAQTRSLEKLQWFIRAHLDNGNGNI", "function": "May contribute to bacterial adherence, or be involved in the protection of the bacteria, or both.", "AFDB_id": "AF-Q47953-F1-model_v4" }, { "swissprot_id": "Q6D4X4", "sequence": "MIDLRLPLTDIHRHLDGNIRAQSILELGRQYNIALPASDLDALRPHVQVTKNEPDLLSFLQKLDWGVAVLGSLDACRRVAYENVEDAMNAGLDYAELRFSPYYMAMNHKLPIAGVVEAVIDGITAGSRDFDTDIRLIGIMSRTFGTEACQQELDALLSQRDRIVALDLAGDELGYPGAQFTSHFQQARDAGWHITVHAGEAAGPESIWQAINHLGAERIGHGVTAIIDPRLMTHMAETGIGIESCLTSNIQTSTVETLDKHPLIHFLRYGIPATINTDDPAVQGIEIRHEYEVAAPLAGLTAVETRKAQENGLNIAFISEQEKQQLREKVLRKRASA", "function": "Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.", "AFDB_id": "AF-Q6D4X4-F1-model_v4" }, { "swissprot_id": "P0A0V1", "sequence": "MKNQVKKILGMSVVAAMVIVGCSHAPKSGISKSNKAYKEATKGAPDWVVGDLEKVAKYEKYSGVFLGRAEDLITNNDVDYSTNQATAKARANLAANLKSTLQKDLENEKTRTVDASGKRSISGTDTEKISQLVDKELIASKMLARYVGKDRVFVLVGLDKQIVDKVREELGMVKK", "function": "Could play a role in the pathogenesis of H.pylori by serving as an inflammatory mediator.", "AFDB_id": "AF-P0A0V1-F1-model_v4" }, { "swissprot_id": "O27041", "sequence": "MSDMFLPARMRKLKIITLDQYSDSVVRSLHEEGVTQIDDISERIQQDAEWRQILKPSRATPYTGRVSSLLMKTSGILDFLGSVAAEEKGLRDTIREFINPPIFEKREVEELDTESLIERAEETLGRVESETRVMEEKLNELDSERSAVESSLSVAEKLKDFDIDFSDLQDSEYITGIAGRITAENLPELRDKLADITDELVISDREGENKAERILIIVTLKKHADSIASVLRRMEFERFEISELQGRPSEIISSSKTRLEEISRERKEIISKLRDINAEWEDELLVLREQLEIEKERNEVFSLFGETRKTVMLEAWVPLKEADRVIAVVEESSEGTALTDLEDPDPEEVPVLLDNPRFAKPYETFVEMYSPLKYNEIDPTIFMAFVFPFFFGFCLTDAGYGIIDALIGFILYRGLGKVNNFMRNFGIIMMSCGVWAFILGMVTNGFIGDFFPRFFNITLPTVIPAIDAFVNPQNILIMALTVGVLHINFGLILGARNNIRLGNMREALGSQIVWLILELGIILYLVGGMIFGAPLIILAFAMLLYYNGLFGLMDVSGFLGTLLSYARLLALCLSTGGIAMTVNILTGLSYEMIPVIGVVLAPIIFVFGHIANNAFQSLGAFINSLRLHYVEFFAQFYMGGKNKFNAFRAERNFTKIRR", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-O27041-F1-model_v4" }, { "swissprot_id": "A0A084B9Y9", "sequence": "MWASFPRPEAIPPGYVGETQHQHRSIMLLNGKSRSWIFLYERLPAPSHDRVKCIAEDVIEFADSFADWSIWNNTKLEDVVDHSTAGMSNLEEGIVKNFSHGRIVLVGDACHKFTSNAGLGLNNGIQDIVAGCNSIRKVVTESGFDLPDVKALEATFKTYYEMRLGPFNDDFIHSKMMTRMQAWANTWYFLFTRYLFFIFSEWILFRFTMLRRVCTGLVLTMHLAKSRLVALLNGFIRSGYHSFIWISAIRPCNDQLLNQLLAGAIQIEILCSLNTWRISSCRAPLLLVFDQARG", "function": "FAD-dependent monooxygenase; part of the satratoxin SC1 cluster involved in the biosynthesis of satratoxins, trichothecene mycotoxins that are associated with human food poisonings. Satratoxins are suggested to be made by products of multiple gene clusters (SC1, SC2 and SC3) that encode 21 proteins in all, including polyketide synthases, acetyltransferases, and other enzymes expected to modify the trichothecene skeleton. SC1 encodes 10 proteins, SAT1 to SAT10. The largest are SAT8, which encodes a putative polyketide synthase (PKS) with a conventional non-reducing architecture, and SAT10, a putative protein containing four ankyrin repeats and thus may be involved in protein scaffolding. The putative short-chain reductase SAT3 may assist the PKS in some capacity. SAT6 contains a secretory lipase domain and acts probably as a trichothecene esterase. SAT5 encodes a putative acetyltransferase, and so, with SAT6, may affect endogenous protection from toxicity. The probable transcription factor SAT9 may regulate the expression of the SC1 cluster. SC2 encodes proteins SAT11 to SAT16, the largest of which encodes the putative reducing PKS SAT13. SAT11 is a cytochrome P450 monooxygenase, while SAT14 and SAT16 are probable acetyltransferases. The SC2 cluster may be regulated by the transcription factor SAT15. SC3 is a small cluster that encodes 5 proteins, SAT17 to SAT21. SAT21 is a putative MFS-type transporter which may have a role in exporting secondary metabolites. The four other proteins putatively encoded in SC3 include the taurine hydroxylase-like protein SAT17, the O-methyltransferase SAT18, the acetyltransferase SAT19, and the Cys6-type zinc finger SAT20, the latter being probably involved in regulation of SC3 expression.", "AFDB_id": "AF-A0A084B9Y9-F1-model_v4" }, { "swissprot_id": "Q93VM9", "sequence": "MDAFRDAILQRAPIETFALKTVQHFIQPQKQTKLAQDENQMLENMLRTLLQELVAAAAQSGEQIMQYGQLIDDDDDDDDIHGQIPHLLDVVLYLCEKEHVEGGMIFQLLEDLTEMSTMKNCKDVFGYIESKQDILGKQELFARGKLVMLRTCNQLLRRLSKANDVVFCGRILMFLAHFFPLSERSAVNIKGVFNTSNETKYEKDPPKGISVDFNFYKTFWSLQEYFCNPASLTSASTKWQKFSSSLAVVLNTFDAQPLSEEEGEANSLEEEAATFNIKYLTSSKLMGLELKDSSFRRHILLQCLIMFDYLRAPGKNDKDLPSETMKEELKSCEDRVKKLLEITPPKGKEFLRAVEHILEREKNWVWWKRDGCPPFEKQPIDKKSPNAGQKKRRQRWRLGNKELSQLWRWADQNPNALTDSQRVRTPDIADYWKPLAEDMDPSAGIEDEYHHKNNRVYCWKGLRFTARQDLEGFSRFTEMGIEGVVPVELLPPEVRSKYQAKPNEKAKRAKKEETKGGSHETEGNQIGVSNSEAEAEGGRGDAETMESDAIADTPTPEEQQRLGGSDTENGQEAGQIEDGETEEAGLMDTDLDHPPMPVS", "function": "Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export. Contributes to the integrity of the endogenous trans-acting small interfering RNA (ta-siRNA) pathway. May process or transport a long RNA molecule so that it can be a template for secondary siRNA production. May participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center. Required for the generation of functional messenger ribonucleoproteins (mRNPs). Plays an important roles in plant innate immunity.", "AFDB_id": "AF-Q93VM9-F1-model_v4" }, { "swissprot_id": "O36019", "sequence": "MPRLNTQLPRMYSAPPGHSKAVSTELNKDLSSVGGRSAKLGQVIHHCFYKTGLIILESRLNVFGTSRPRESSKNNKWFNLEIVETELYAEQFKIWKNIELSPSRKIPPMVLHTYLDISDLSKNQTLSVSDGTHSHAINFNNMSTMKIVLERWIVNLDGEALSTPLELAVLYKKLVVLFRSLYTYTHLMPLWKLKSKIHKLRAHGTSLKVGCALSTDDVLSNDFLPISAPISSSLGSSIATFSFSPVGTPAGDFRISVQYRKNCHFEVHDSDALLSNQLLSADKHQLAASNNSQDFEDGKQYDQPPPSFATRLAKQSDPNSLLQSEIQHLASIESITAQAAPLVTIHPFKSPSLSASPGSNFDNMSISPKVAVNRYIHRGPSATSLNKFSMISDAASKSRAKLPPLTSGSLKLNTLDISNTPNLRRFSSSFGPRERKESFSSRNRLPLVNHPIRSIFKHNVSENPITDHSEHAVYDSEFASKDDLSGFIQLLDSHAHHLNASEGSKSSGSFPGKVQTLTSGISPVAHPHNSLGSSNEIFDIDTYNHSIDNSGSRFTEAVKHNLGNSSHSIMRHHTLGTLRSRPSFSEKSTFPAPLTSISQASTFQGDNRSPSTVIPHTQTEVPSANDTSKQLASLHDMRKSQSPICARSATSAGLPRFEYHTSLSKSLEHSSTPASLQATKTPSPSFVLEPGIPQEYKKHFDNLSEERRQCLTPSTPTYEYYNEHNPNYDDDLLFTMTDMTLEPHDVSAIRLGSPKSDD", "function": "Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phase and has a role in meiosis and sporulation.", "AFDB_id": "AF-O36019-F1-model_v4" }, { "swissprot_id": "O27083", "sequence": "MQTPEIKEGTEQYLWRRKTMNPGDKGVKRKGSDRQREKMSVIVMAGTEDARRIISRLSGMPWVEVTATATTEHGSDLAEKSGASRTVTGALDSDGLRELMADLDACILIDATHPFAAQATENALRACRETGTIYVRFERPEVIPDGVIRVGSFREAGEVASSLIGDGEVVMHLAGVSTLGDVLRSLEPERVAVRVLPSTSSIEKCLQLGVPPSHIIAMQGRFSAEMNLALLREYRAGAVITKESGETGGLPEKVEAASELGIPVILVERPEVNLEGEAVFGNINDLMDHVLKILRDMGQPGD", "function": "Catalyzes the reduction of the macrocycle of cobalt-precorrin-6A to cobalt-precorrin-6B.", "AFDB_id": "AF-O27083-F1-model_v4" }, { "swissprot_id": "Q0AZE0", "sequence": "MKIILVNNRFKENTEKKAQEIAGQLSALNVEVIIDNGLDEPYAGTVDFIMVLGGDGTMLRAARRYGQRAIPVLGVNMGTVGFLSNIEINELAEYLPLILREEYSLEARMMLEVAVFQQQSLLTRVFCLNELLLRSNSPRMLSFALEISGQKLEPYRGDGLIVSTTTGSTAYSLSAGGPIADPQLDAFIVTPVASHIINKRPLVVSPEREISLHLLEEREAIIGIDGQIKMDFGAENRVLIKRAPHPLLMVNLKAKPFFTSIDRSLQRQ", "function": "Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.", "AFDB_id": "AF-Q0AZE0-F1-model_v4" }, { "swissprot_id": "Q7M826", "sequence": "MKFIIDRFDGKKNYEQIYTLAKEDIEAKTLLGVLLLIKQTQDITLNFTASCRMAICGACAVRVNGHSYLACDTKMTELFEEYKNSDTFRISPLGNHRVISDLVVDWEPAIENLRKIKPGLVAKSEFSAKEGCQQNQEEFDRIIKQWDCILCGSCVSECNKFSADQSDYMEPFVFTQAWRLANDSRSKDPMIHVKPAVANGLWNCVHCHECTNRCPKHISAAEDIANLRVMAMKKGLNTGVGPAHAKAFHTDLVEGSGRLNEIRLALRIEGVATVARTGMAITLMRAGKMNPLEIFGGHTIKGHEDLVKMIDAAKAATKE", "function": "Iron-sulfur subunit of 8-methylmenaquinol:fumarate reductase (MFR), that catalyzes the reduction of fumarate using 8-methylmenaquinol-6 as electron donor. The complex shows no succinate oxidation activity. Is involved in anaerobic metabolism.", "AFDB_id": "AF-Q7M826-F1-model_v4" }, { "swissprot_id": "P36678", "sequence": "MIKSWWAEKSTSEKQIVAALAVLSLGVFCWLGVIKPIDTYIAEHQSHAQKIKKDIKWMQDQASTHGLLGHPALTQPIKNILLEEAKRENLAITLENGPDNTLTIHPVTAPLENVSRWLTTAQVTYGIVIEDLQFTLAGNEEITLRHLSFREQQ", "function": "Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Plays a role in the complex assembly and recruits GspL resulting in a stable complex in the inner membrane. Provides thus a link between the energy-providing GspE protein in the cytoplasm and the rest of the T2SS machinery.", "AFDB_id": "AF-P36678-F1-model_v4" }, { "swissprot_id": "P13496", "sequence": "MSEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMFVRPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKPQFTPSQPLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKEMAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVDAALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAKKEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYKQMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDIVVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAGSSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCVASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLPSDQHVIKSGLSQHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCERIYEQDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQLIKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVDKWKQKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHNISLSGNTSTAPGISNVSYSAPAGTAPVVAEEVELLKNAFNQERNQRLRLQAQDMRAKLSQFEPLHVPQPQDQRITALESELTRMKHAWVLSLLQVRSQDSVNSGTRIDAVALQRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPTVDVKRVLQI", "function": "Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.", "AFDB_id": "AF-P13496-F1-model_v4" }, { "swissprot_id": "Q94AQ8", "sequence": "MASLISFSLLPKPKAVRSSISAPQTQTINTEKLEDKFGRKGIKFSESNNIPMVELKVRNGSSLKLSLSDAHVLSYKPKVYWKDEGFEEVLYTVDGDESRGGVGVVIVNGEEPKGGSSVISGCDWSVKDTDSDAIDALQIELSCTAGVLDITYIVSLYPVSMATALVVKNNGRKPVTLKPGIMSYLRFKKRSGAGIQGLKGCSYCPNPPLSSPFELLSPSEAMKAESSGWFGSEEGEKPGIWAVEDSVITLLEKKMSRIYGAPPAERLKAVYNTPPSKFETIDQGRGLFFRMIRIGFEEMYVGSPGSMWDKYGKQHYFVCTGPTSMLVPVDVASGETWRGAMVIEHDNL", "function": "NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-Q94AQ8-F1-model_v4" }, { "swissprot_id": "A0A0P1AL95", "sequence": "MTGILCFPPFARFFMLLSGCAWLAGVSSGTSLVASAFSDENQLSEFVHVAEIAQIHRNLRGHINSAIIEANDTSEERMQPNNVVGEGKAPSGAQETVAQILVKGMNKVADFLKDLTRSQK", "function": "Secreted effector that does not suppress pattern-triggered immunity (PTI) in plant host.", "AFDB_id": "AF-A0A0P1AL95-F1-model_v4" }, { "swissprot_id": "P51688", "sequence": "MSCPVPACCALLLVLGLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNEL", "function": "Catalyzes a step in lysosomal heparan sulfate degradation.", "AFDB_id": "AF-P51688-F1-model_v4" }, { "swissprot_id": "O94664", "sequence": "MPRRAVLFRGNSFISFSSISSGNESSAHGDASLGQADKPLTVDVLDAWTTQFTKKQTRVFHEAYVSAYIDLQQKYARLERLQEQILNLERSLLNYKSLKSNSTTTVATVPSEKRYFFRRKPKTSSTTNSLSSSSSSVSHMNQDANPNSTVLTFTAVPYDSCLPAPDRHTPSSASSRASETGTTSPQSMRNQISLLYSKVDQVKTEIASAQAVMHDLLRTYPGSESLQQSTHTQF", "function": "Has a role in meiosis.", "AFDB_id": "AF-O94664-F1-model_v4" }, { "swissprot_id": "Q05022", "sequence": "MVASTKRKRDEDFPLSREDSTKQPSTSSLVRNTEEVSFPRGGASALTPLELKQVANEAASDVLFGNESVKASEPASRPLKKKKTTKKSTSKDSEASSANSDEARAGLIEHVNFKTLKNGSSLLGQISAITKQDLCITFTDGISGYVNLTHISEEFTSILEDLDEDMDSDTDAADEKKSKVEDAEYESSDDEDEKLDKSNELPNLRRYFHIGQWLRCSVIKNTSLEPSTKKSKKKRIELTIEPSSVNIYADEDLVKSTSIQCAVKSIEDHGATLDVGLPGFTGFIAKKDFGNFEKLLPGAVFLGNITKKSDRSIVVNTDFSDKKNKITQISSIDAIIPGQIVDLLCESITKNGIAGKVFGLVSGVVNVSHLRTFSEEDLKHKFVIGSSIRCRIIACLENKSGDKVLILSNLPHILKLEDALRSTEGLDAFPIGYTFESCSIKGRDSEYLYLALDDDRLGKVHSSRVGEIENSENLSSRVLGYSPVDDIYQLSTDPKYLKLKYLRTNDIPIGELLPSCEITSVSSSGIELKIFNGQFKASVPPLHISDTRLVYPERKFKIGSKVKGRVISVNSRGNVHVTLKKSLVNIEDNELPLVSTYENAKNIKEKNEKTLATIQVFKPNGCIISFFGGLSGFLPNSEISEVFVKRPEEHLRLGQTVIVKLLDVDADRRRIIATCKVSNEQAAQQKDTIENIVPGRTIITVHVIEKTKDSVIVEIPDVGLRGVIYVGHLSDSRIEQNRAQLKKLRIGTELTGLVIDKDTRTRVFNMSLKSSLIKDAKKETLPLTYDDVKDLNKDVPMHAYIKSISDKGLFVAFNGKFIGLVLPSYAVDSRDIDISKAFYINQSVTVYLLRTDDKNQKFLLSLKAPKVKEEKKKVESNIEDPVDSSIKSWDDLSIGSIVKAKIKSVKKNQLNVILAANLHGRVDIAEVFDTYEEITDKKQPLSNYKKDDVIKVKIIGNHDVKSHKFLPITHKISKASVLELSMKPSELKSKEVHTKSLEEINIGQELTGFVNNSSGNHLWLTISPVLKARISLLDLADNDSNFSENIESVFPLGSALQVKVASIDREHGFVNAIGKSHVDINMSTIKVGDELPGRVLKIAEKYVLLDLGNKVTGISFITDALNDFSLTLKEAFEDKINNVIPTTVLSVDEQNKKIELSLRPATAKTRSIKSHEDLKQGEIVDGIVKNVNDKGIFVYLSRKVEAFVPVSKLSDSYLKEWKKFYKPMQYVLGKVVTCDEDSRISLTLRESEINGDLKVLKTYSDIKAGDVFEGTIKSVTDFGVFVKLDNTVNVTGLAHITEIADKKPEDLSALFGVGDRVKAIVLKTNPEKKQISLSLKASHFSKEAELASTTTTTTTVDQLEKEDEDEVMADAGFNDSDSESDIGDQNTEVADRKPETSSDGLSLSAGFDWTASILDQAQEEEESDQDQEDFTENKKHKHKRRKENVVQDKTIDINTRAPESVADFERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKATAKKFGGEKVSIWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDKKKVEDLFERIITKKITRKQAKFFFNKWLQFEESEGDEKTIEYVKAKATEYVASHESQKADE", "function": "Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.", "AFDB_id": "AF-Q05022-F1-model_v4" }, { "swissprot_id": "Q09858", "sequence": "MTSRKEQLDAFLSRTLSETIAHIPLEKFAQCFPSMKKGKVIAVIHQQLIEFFEKSCKQEYANLIKERDLNKKLDMLDECIHDAEFRKLHGESEVDISNKQPQEILKAHLYSHKRELLDKLNQDLLDIDKENEGLSTQIAAGRKSN", "function": "Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle.", "AFDB_id": "AF-Q09858-F1-model_v4" }, { "swissprot_id": "Q9ZCW4", "sequence": "MTLFRSGIILAFLTFIARIFGLVREQFIASLFGSTPMGDSMNIAFKLPNLFRRIFAEGALSSVFIPIYNEKMLISKKAANNFSGKVFTLLSLTLIVIIALMQIFMPQLILCIAPGFYAKKEKFELTVFLCRITIPYLIFVSLTALLGGILNSVKKFAAFAFSPIILSVCVIIFTLIFGNYIESTISISVSLIIAGILQVVFMFICVKKADLHFPIIFHTNDPDVKKLLINMGPATISSGVQQLNLFISQSISSFIEGAISILAYADRIYQFPLSIIGTSFSTILLPEMSKVYKSNDIVSAQKIQNNAIRIGLLLSLPATFGIIILSHPITNIIYERGVFTPQDTTNTAEAISAFALGLPAFILAKILTPIFYANGDTKTPLKITLFSIIINTNMNLLLMDSLKHIGIAVGTSIAAWYNLGLLYSYSTKQHKLHIEAGIKLFCAKILLCCTLMSIIIALIKHYYLEYLYSEYLLIKVSMLGSTIIIGVAIFFGTAYLLKVVNYDNSTK", "function": "Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.", "AFDB_id": "AF-Q9ZCW4-F1-model_v4" }, { "swissprot_id": "Q9X5M1", "sequence": "MNAHPAGPRHAEELHHADVPDKPQSPDEIMLLAPNVWPRNLVRGADGVVTIAGVPVTDLAAKFGTPLFVIDEDDFRTRCRDIAAAFGGGQYVHYAAKAFLCSEIARWVDEEGLSLDVATGGELAVALHAGFPASRITVHGNNKSVAELTAAVQAGVGHVVLDSEIEIERLDQIAGAAGVVQDVLVRVTVGVEAHTHEFISTAHEDQKFGLSLATGAAMNAIRRVFATDNLRLVGLHSHIGSQIFDVAGFEIAAHRVIGLLRDVVAEFGVEKTSQMSIVDLGGGLGISYLPHDDPPPMKELADKLLEIVRTESAAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVAVSQTAHRRYVSVDGGMSDNIRTSLYAAQYDARLVSRVSDAPPALARIVGKHCESGDIVVRDTWVSDDIAPGDLIGVAATGAYCYSMSSRYNLLCRPAVVAVADGQARLVLRRETVEDLLSLEVKGQ", "function": "Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.", "AFDB_id": "AF-Q9X5M1-F1-model_v4" }, { "swissprot_id": "Q9K920", "sequence": "MLEQGYHLYEAVQFLAIHAPSSAQKKMNAMLMDLRSGYPLHKALDHLQLPQDVQLLLYVSERNGDLAQGFRKSGELFKKREEMKRKWEGAMRYPLLLIIVTLLLMFILMYFVLPHHQTLYRSLQIELPVITKLVIACSEKLPWLFTAFFVVAILLVLTYFVTFHRFPPTKKVTVLLRIPGLSQWTKEVITCLFCLTLGGLLKGGLSIMEALSICKEQDFFLFFRSEGEEMMLELENGERLYECLRRRPHYLKELPFVVENGEKTGNLAKDLLYFSDYQLEEFERRVKKWLVAIQPIVFSMIGAVILVLFLAMMLPVFQMIGAI", "function": "Required for transformation and DNA binding.", "AFDB_id": "AF-Q9K920-F1-model_v4" }, { "swissprot_id": "Q3JF36", "sequence": "MMHITHLDIRNFRNLKHIELHPSKGVNILSGANSSGKTSFLEAIYLLGLGRSFRTVQLISAIQAGMESLRVVAKVKQVGGSHTAGVEFGPAGFRARINKDTVKKRSQLATQLPLLYMSSYSHVVLDGGPRYRRQWLDWSLFHLEPGFHDLWWCYQRTLKQRNHVLRVHKPSWQQEINAWNKKLSTYGEQITSLREAILFKLQDSVSQLFTALAHQPISPVTMEFKQGWARTVRLEEILNESLNYDRAAGYTRYGPHRAEVAFYVDGKDVREILSRGQQKVFCYSLALSQANLLYRTKEQNCIFLIDDFTSELDADHRKRLLTLLNKLGMQVFATTIESLGSEIKAHPNIKEFHVKLGQVEEMV", "function": "The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.", "AFDB_id": "AF-Q3JF36-F1-model_v4" }, { "swissprot_id": "Q8Y7I6", "sequence": "MKRTTRYSRKYVPSIDGLRALAVIAVIAYHLNFSWAKGGFIGVDIFFVLSGYLITNILLTQWEKNQSLQLKQFWIRRFRRLIPAVYVMIVVVVIYSVFFHPEILKNLRGDAIASFFYVSNWWFIFHNVSYFDSFGLPSPLKNLWSLAIEEQFYLIWPAFLLVFLKWVKNPKLLLKIVIGLGLLSAVWMTILYVPGTDPSRVYYGTDTRAFDLLSGCALAFVWPFNRLSPVVPRKSKAVLNIAGTISILCFILFTAFVSEYQPFLYRGGLLFVAILGVIMIATISHPASYLSKIFSFKPLRWIGTRSYGIYLWHYPIITLTTPVLEITQPNIWRAILQVAATFIIAELSFRFIETPIRKNGFINYFKGFKDKNYFIWKNKPVGKWLSIAGVVAVLAIFTLGMSNVLSVNTNAEKQQTSVKTTTSTPDEKKDDKKEDKATKDKEADSNKASEQKETQKPDNKNKSAATPKTIITQTVAIGDSVMLDIEPYLKEAVPNITIDGLVGRQLRDAITTATGYKKFNSENSSVILELGTNGPFTEDQLNDLLDQFDKATIYLVNTRVPRGWQSDVNKSIANAASRPNVTVVDWYSRSSGQSQYFAPDGVHLTKAGAQAYVAMLTSVMNK", "function": "Responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan. O-acetylation of the peptidoglycan is the major determinant for lysozyme resistance. Critical for virulence and escape from innate immune response of the host. Involved at both early and later stages of listeriosis in the mouse model of infection. Required for successful host colonization and for intracellular survival of bacteria in macrophages of the infected host. Controls the production of inflammatory mediators in the liver of the infected host. Confers resistance to host antimicrobial molecules and to cell wall-targeting molecules such as beta-lactam antibiotics and bacteriocins.", "AFDB_id": "AF-Q8Y7I6-F1-model_v4" }, { "swissprot_id": "P0AE86", "sequence": "MRIVTAAVMASTLAVSSLSHAAEVGSGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSELETMHRLVTAENFDENAVRAQAEKMANEQIARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSSSNSRSQ", "function": "Acts as an accessory protein in the Cpx two-component envelope stress response system. Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the envelope stress response in the absence of inducer. Aids in combating extracytoplasmic protein-mediated toxicity.", "AFDB_id": "AF-P0AE86-F1-model_v4" }, { "swissprot_id": "Q1AGV6", "sequence": "MNRLLLLLALVLSGVAAESIRETETMDPTSMLEYESSGSFTDEVFVDEDDDDDYEDGVDYEIDSESDNDEDYSGSGDDDFDDEDNVEDEDEEETTTLGNQIPEHDFDETKTGRKFDTFNENNEIDNDIRHPAKPKTLEPSNEIPMASIGSSGFFQRTEVIVAIIAGTLVGLVVAVSFIVFLVIRRNQNGDLVKKPIYKKTSTMEV", "function": "Cell surface proteoglycan that bears heparan sulfate. Regulates non-canonical Wnt signaling, being necessary and sufficient for fibronectrin-mediated translocation of dvl2/dsh to the plasma membrane. Required for proper convergent extension movements during gastrulation, which shape the neural plate, and for subsequent neural tube closure.", "AFDB_id": "AF-Q1AGV6-F1-model_v4" }, { "swissprot_id": "C0QXH9", "sequence": "MNEYDIKDTIAALSTPYSKSALAIIRMSGSKALEIASKICFYANNENKNINNFEHRKSYYALIKDENNIPVDEVIVLSSLSPNTFTSEDTIEFISHGSIVVIDALMNLLIKNGARAANRGEFTYRAYINGRIGISEAEAIHDLIDSNNKLMAEASIYKMRGRLTREIDKLRENIKNSLMLVYGELDFPEDETESFSYDKLIENFEIIKKDIENILSNSKRVENLINGIKVAILGRVNAGKSSIFNMILDRERAIVSNIAGTTRDFLSENIYIENIPFYLMDTAGFHKKADNDIELEGIERAKKCAYESDIILAVFDGSDIANEDDINLIEFLNALENKNIIYILNKSDEDKKFNKEIDNANIINISTKTKDGKDKLISALKDYVSDSDMDIFNKETYVNNRERCYLENGLKQIDICIKKSLESYSLDEVAEEMNILNNILGNVSGKVDAEEVINEIFANFCIGK", "function": "Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.", "AFDB_id": "AF-C0QXH9-F1-model_v4" }, { "swissprot_id": "O31625", "sequence": "MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINRVAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK", "function": "Transcription factor involved in spore coat assembly and spore resistance. Regulates the transcription of at least cgeA, cotG and cotS.", "AFDB_id": "AF-O31625-F1-model_v4" }, { "swissprot_id": "Q12204", "sequence": "MLRFTHRGLPSSTRFRNIFVRLNHIYVPWFYAIDVPNSKPYLPTYQTLHSPKKFKPFSVDDSNRLEKASKRQERRPVLVNEDYLFKVDLSHMELSPTYWEGPTYQVRRGVWFDSSNQPLSSDLTSEIEGLYKQLKFDDSNDDPTTTPPAESQDIFRLKGKYPVDKENEGEQKNGSSNKDENESTFKFILFANKQTAFLLSDLDGGKLQLAFLRSNLAQSLPINATMITRSYKYSSSATTKQTSTSFKAAKTPQTEVADGSNSSKSRSIETKLEKKVSNLFNLSDFLQLFNGNASKDQDDAQSLEKQMETDYNNADNSQGANASSKIEDGKNSGASDRQIRSNRRDVDNLILCVHGIGQTLGKKYEYVNFAHTVNLLRSNMKKIYNNSEKLQSLNTAPDYKSNCNVQVLPITWRHSISFQTDAKEENIENPDLPTLSQVTVNGVLPLRKLLADGLLDILLYVEPYYQDMILQQVTSQLNKTYRIFKEFNPEFDGKVHLVGHSLGSMILFDILSKQKKYELEFQVDNLFFIGSPIGLLKLIQRTKIGDRPEFPNDLERKLTVQRPQCKDIYNVYHVCDPISYRMEPLVSKEMAHYEQTYLPHCSEAYGLTSKVLEFGENIWKDLPGTDENNLQSKKTSPEKKEVKLSENLTRMLTGLNYTGRLDYAMSPSLLEVDFISAIKSHVSYFEEPDIAAFILKEILSKHENASEIYVKRKTG", "function": "Probable phospholipase that hydrolyzes phosphatidic acid.", "AFDB_id": "AF-Q12204-F1-model_v4" }, { "swissprot_id": "Q55C82", "sequence": "MQESKYQELQKQAEKSVKESMTLFQDWPNKGVGFQDISNLFLCYDKFSDVLDYYEHRFSDVDLVVGLEARGFILGTAFAQRMKLPMMMIRKKGKLPGPCFRESYKKEYGTDEFEVQEKALSKVVVKPSKKYHVLIMDDILAPGGTMAASIELTKKVLINNGIKDFKISTSLISSIKVLNGKEKIYEKYNDVSVDIIIEM", "function": "Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.", "AFDB_id": "AF-Q55C82-F1-model_v4" }, { "swissprot_id": "O94680", "sequence": "MASSKKSKTHKKKKEVKSPIDLPNSKKPTRALSEQPSASETQSVSNKSRKSKFGKRLNFILGAILGICGAFFFAVGDDNAVFDPATLDKFGNMLGSSDLFDDIKGYLSYNVFKDAPFTTDKPSQSPSGNEVQVGLDMYNEGYRSDHPVIMVPGVISSGLESWSFNNCSIPYFRKRLWGSWSMLKAMFLDKQCWLEHLMLDKKTGLDPKGIKLRAAQGFEAADFFITGYWIWSKVIENLAAIGYEPNNMLSASYDWRLSYANLEERDKYFSKLKMFIEYSNIVHKKKVVLISHSMGSQVTYYFFKWVEAEGYGNGGPTWVNDHIEAFINISGSLIGAPKTVAALLSGEMKDTAQLNQFSVYGLEKFFSRSERAMMVRTMGGVSSMLPKGGDVVWGNASWAPDDLNQTNFSNGAIIRYREDIDKDHDEFDIDDALQFLKNVTDDDFKVMLAKNYSHGLAWTEKEVLKNNEMPSKWINPLETSLPYAPDMKIYCVHGVGKPTERGYYYTNNPEGQPVIDSSVNDGTKVENGIVMDDGDGTLPILALGLVCNKVWQTKRFNPANTSITNYEIKHEPAAFDLRGGPRSAEHVDILGHSELNEIILKVSSGHGDSVPNRYISDIQEIINEINLDKPRN", "function": "Catalyzes triacylglycerol (TAG) formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol (DAG), thus forming an sn-1-lysophospholipid. Plays a major role in triacylglycerol formation at log phase. Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains.", "AFDB_id": "AF-O94680-F1-model_v4" }, { "swissprot_id": "Q8N4C6", "sequence": "MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH", "function": "Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole.", "AFDB_id": "AF-Q8N4C6-F1-model_v4" }, { "swissprot_id": "O74395", "sequence": "MRLKSFSTTLDTLRRRFNDSSSEEDKLEKNIQDETSIKEVSLQDAKQSDEKGVEEKVFNDESFSIDVAPKPEDELSGIVKARYLTEHSSRISFYICYFSIFLLFFAISFQAECYYSLTAYATSAFAGHSLLSTIAVANNIISAAIKPPLARLSDVFGRLEAFLFSLLLYLVGLILMAASTNVQTYAGGSVLYNAGYTGVELIMTIFMADTSSMANRSLVLGISYLPFVVTIWIGPRVAQEFYMHSTWRWGIAVWTILIPACSIPFLAVYSYYQFRAWREGALKGTLTINPVELFKKLDIIGLILMTAGLALVLLSISLASYDTGKWSDAKFIVMIIIGGLCLIAFVLYEIFVASFPALPFRLMREPTIGACCAMSFLFYITFYCWDNYYYSFLQVVHYTSITAAGYISYTYSFTSCATGFFLGILIRLTKRYKWYFVASIPVYILGQGLMIRYRGEQYNWGYQIMPQIIVGIGGGVIANLLTVAVQTVVSTENFAIVTALVSTVTPIGGAVGSAISGAIWNSVMPKRLEKNLPSDLKDQAYTIFESLTVQLSYTRGTDARNAIILSYSEVQKILTSVATGFAGAMIFPVWFVANPRLSTVKTHIFDSKESKV", "function": "Involved in the transport of siderophore iron and so has a role in iron homeostasis.", "AFDB_id": "AF-O74395-F1-model_v4" }, { "swissprot_id": "Q9BXW4", "sequence": "MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL", "function": "Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.", "AFDB_id": "AF-Q9BXW4-F1-model_v4" }, { "swissprot_id": "P52701", "sequence": "MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL", "function": "Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.", "AFDB_id": "AF-P52701-F1-model_v4" }, { "swissprot_id": "P32364", "sequence": "MHWNIISKEQSSSSVSLPTLDSSEPCHIEVILRAIPEKGLQNNESTFKIDPYENTVLFRTNNPLHETTKETHSTFQFDKVFDANATQEDVQKFLVHPIINDVLNGYNGTVITYGPSFSGKSYSLIGSKESEGILPNICKTLFDTLEKNEETKGDSFSVSVLAFEIYMEKTYDLLVPLPERKPLKLHRSSSKMDLEIKDICPAHVGSYEDLRSYIQAVQNVGNRMACGDKTERSRSHLVFQLHVEQRNRKDDILKNSSLYLVDLHGAEKFDKRTESTLSQDALKKLNQSIEALKNTVRSLSMKERDSAYSAKGSHSSAYRESQLTEVLKDSLGGNRKTKVILTCFLSNVPTTLSTLEFGDSIRQINNKVTDNTTGLNLKKKMDLFIQDMKIKDDNYVAQINILKAEIDSLKSLHNKSLPEDDEKKMLENTKKENIKLKLQLDSITQLLSSSTNEDPNNRIDEEVSEILTKRCEQIAQLELSFDRQMNSNSKLQQELEYKKSKEEALESMNVRLLEQIQLQEREIQELLTTNAILKGELETHTKLTETRSERIKSLESSVKELSLNKSAIPSPRRGSMSSSSGNTMLHIEEGSEISNSPWSANTSSKPLVWGARKVSSSSIATTGSQESFVARPFKKGLNLHSIKVTSSTPKSPSSGS", "function": "Possible microtubule-based motor that can interact or substitute with myosin 2 (MYO2).", "AFDB_id": "AF-P32364-F1-model_v4" }, { "swissprot_id": "Q65XS5", "sequence": "MKPPRRWMYGRGGGKGKPAGLLLLGVFLCLSVVLLLLLHGSSPSLEGEGRKPEAVEAAGGGGEEEEVAVARAEVEEAPLPPGNARLAFLFIARNRLPLDLVWDAFFRGDKEGRFSIFVHSRPGFVLTRATTRSGFFYNRQVNNSVQVDWGEASMIEAERVLLAHALKDPLNERFVFVSDSCVPLYNFNYTYDYIMSSSTSFVDSFADTKAGRYNPRMDPIIPVENWRKGSQWAVLTRKHAEVVVEDEEVLPEFQKHCRRRPLPEFWRDWDRPIPAEAWKAHNCIPDEHYVQTLLAQHGLEEELTRRSVTHSAWDLSSSKDRERRGWHPVTYKISDATPALVKSIKDIDNIYYETENRKEWCTSNGKPAPCFLFARKFTRAAGLKLLDLSLIAANGASTM", "function": "Glycosyltransferase required for the regulation of cellulose biosynthesis in the cell wall. Required for the biosynthesis of hexoses (glucose, mannose and galactose) in both cellulosic and non-cellulosic (pectins and hemicelluloses) components of cell walls. Required for the formation of arabinogalactan proteins which contribute to the strengthening of cell walls. Possesses low glycosyltransferase activity.", "AFDB_id": "AF-Q65XS5-F1-model_v4" }, { "swissprot_id": "P26502", "sequence": "MLFHAAEKTGHHFTIGAAGVDVFFVISGFIMWVISDRRSVTPVEFIADRARRIVPVYWLATGVMVAGALAGLFPNLVLTLEHVLASLFFVPARSPSSGEIWPVLVQGWTLNFEMLFYAVFAGSLFMPRNWRLPVVSGLFLALVIAGRVVAFDDAVMLTYTRPVILEFVAGMIIGEFWLKGRVPPLAVGSALFACSLGGFALIGVLGLPFDELTTGPLAVLLVIGVLSLEANGCVRALSLPGLLGDASYSIYLWHTFAISVVAKAGLAIGLGAPATMFAAVLSGTLIGIAAYMMLERPLLRRGRARRVTAGLAGRAAE", "function": "Required for the acetyl modification of the third sugar (glucose) of the octasaccharide subunit of succinoglycan (EPS I).", "AFDB_id": "AF-P26502-F1-model_v4" }, { "swissprot_id": "Q80UF4", "sequence": "MAKSPGNSTLEDSLGQYQRSLRERANRSIHQLKCALREVDVTVEEDALDPSTSINVENEDTGVAWHELQHSHAVNQLKALLRQQTNKENETSPPRRRKLSPSRPSECDDGSMPTMHNLVPIINDQSQYIHHLEAEVKFCKDELSGMKNRVQVVVLENERLQQELKSQRPEETLREQTFLDASGNMQNSWIMTREDSRVDEAAKRPFSHGDAETGKTASTGDANKWKLELERLKLTYEAKTDLLESQLMLLRKDLAEYQKTCEDLKERLKHKESLLAASASSRVGGLCLKCAQHEAVLSQTHSNVHIQTIERLTKERDDLMSVLVSVRSSLAEAQKRETSAYEQVKHAVQMTEEANFEKTKALIQCEQLKSELERQTERLEKELASQQEKRAVEKEMIKKEVAREREDAESKMLILSQNIAKLEAQVEKVTREKTAAVSHLEEIQNHVASQEMDVTKVCGEMRFQLNKTKMEKDEVEKEHREYKAKSHKDLEMKVQEIEKLRLELSESEQHVEQEQQKAARARQECLRVTELLGEAERQLHLTRLEKDSIQQSFSNEAKAQALQAQQREQELTQKIQQMETQHDKTESEQYLLLTSQNTFLTKLKEECCLLAKKLEKVSLKSRSQIVRLSQEKRYLCDKLEKLQKRNDELEEQCIQHGRVHETMKERLRQLDKHGQATAQQLVQLLNKQNQLLLERQNLSEEVARLRAQLPSMPQSDC", "function": "Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis.", "AFDB_id": "AF-Q80UF4-F1-model_v4" }, { "swissprot_id": "Q24371", "sequence": "MNIYNKLRAREHGYGNERTYDFALRRLSVAKEDSWRGIAPANYCPDFNPEPPIFSAKFANCDGYRHILAIANEDGKITLQDTTQRNHQPEEQSLVGPQCHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAGSGIRGLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILIWDIRANLNMDLTSRVDNCIYSGHTGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYKKEPLPRHKLPYAGSSTFRGFTNLIVDASGTRLYANCMDNTIYCYNLASYSQRPLACYKGLLNSTFYIKSCLSPDGKYLLSGSSDERAYIWNLDHAEEPLVALAGHTVEVTCVAWGSSHDCPIVTCSDDARHKIWRIGPDLDGLSEAERAEKYRGTASYVREFGKKAFGPSSGNHKYNLRDLESTPRSLKRLMDQNERTPGSVEKTTTKRSFLEMLGVAGQETEATEQPQKRAKPLESRGRRLFGPSSQETACRHIQLQSINEEDASPSKRQKENSAAEDVSPLHKLLSTPSHSPLSENVNHVYTSPPTTSAAAAAVAADALNPPPISAAIYSPTSNLPNYVLDGEAPHLGIMSPKRKAKEKVDWLTNIRKQKLMSGRAHVTLSEKISEEQQADVLASPRLQSLRQSECSPRIHASPRRRISHTDGGGGTPAGSSSHSHSQSQPKTPTSSRRNSETTLLRFFSIQRSSSVPAEETTTTNAAPSSSDPHPPAVTAPAATPLSMRTPTTAVGSD", "function": "Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex.", "AFDB_id": "AF-Q24371-F1-model_v4" }, { "swissprot_id": "P16112", "sequence": "MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRHPRRSRPSTAH", "function": "This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.", "AFDB_id": "AF-P16112-F1-model_v4" }, { "swissprot_id": "B9FXV5", "sequence": "MSQRGDRGEGHARRPGRSSSFGGGHRGGGGVGGAGKGGGGSSGQPPLATNRSFRKSGNGHGGHQRAVSQPDTHGFQPAPAPTALQTPPLRPPAPQNAPAHVPVPAPRPQHHDPSGARAPTLPPSSENTANAPPLKGIPHAAPRAPSRISSTSTSQGAPKGGAYNLQFGSFPMNGGTGGSTMQFPARTSSAPPNLDEQKRMQALPEGHKVVPSGLVPQAPKHQQQQQPLQQQKQQPQSQPPLQQTRKDVVSSNHSSKPINPHIPSQVKSSVHVSPSVPNVAPPRPPVQQIPGMPMSMPFHHQAPLQFGGHNPQIPPQGVVPSSLQMSMGLHGANAPQVAQQMYIPTIQHHHQLQPPTMMHQAAGIPYGPAAHQLTQMSGMMNVGVAPQFTPQQPNKYVTGPTRKTTVKITHPDTHEELKLDKRMDSSGQRGLPSVQQQSQPVSTYGSPMGFYQQNSYNQSTMFYPTTSGVGQVPTVSQGPRFVSTQTVSYISPSMNTGPGSNKDNLAGSTTSGHSQVTGKPHPAGLHMEKSGVQTVTISAPPGKSDVNKLKPAEDVVSHRQKDNEAVSGVRKSGENESKASPITEKHPTPVSQPLQALAANPETTAAASFVVNSVPGDDGKSKESIQRTGSFKDSNKNATKDTRNLSQEPQSASSAEDLKVHTSVKDVCCGVSLMESKGVNKESEQTNAASASPTEMLKAADASSIDRSSARSTSESTENVQEVGKSDVAIGDSEKSGITNKVSPDLTKDDISSGSTGNESHEVCTLDLAEQLPVGASNPDNLDTATSVTDQGQLLKEPSSSVSDENVIMDRSHQSAEKMSDLVDDTVASVASSETLPESIIQNANAKGNTSGNQETGSATSSNILNVLPVPHSVASEDPLKPESMLKDQSSSAPAASARPVSREKPSVEITRTKFTAVKKKKRREMLSKADAAGSSDLYNAYKGPEEKVDFIGASESLDSSSIADHELPDESSEKEVNMGEDEGKKKVELDDWEDAAEMSTPKLERSDSSNQTTEANGRKRYSRDFLLTLAQSCTNLPVGFQMIEYASVLFPNLAGKSYVVDHPSPGRGADRPASRGDRRGVVIEDDRWGKSGHLFGSGRDMSMDNGPPTMNHRGAPGVMRNPRGGLINVGPVAPQMSRSGSDADRWQQKGIFPSPVTPMQVMHKAEKKYVVGKVSDEEEAKQRQLKAILNKLTPQNFEKLFEKVKEVNIDNVATLTGVISQIFDKALMEPTFCEMYANFCFHLAGALPDFSEDNEKITFKRLLLNKCQEEFERGEREEAEADKTEEEGEIKQTKEEREEKRIRARRRMLGNIRLIGELYKKRMLTERIMHECIKKLLGNYQNPDEENIEALCKLMSTIGEMIDHAKAKEHMDAYFDIMLKLSTSQQLSSRVRFMLRDSIDLRKNKWQQRRKVEGPKKIDEVHRDAAQERHAQSSRLARGSVVGSGPRRGAAPMDYGPRGSAAALASPSSQQVGHRGMPSHSRGFGTQDIRFEERSPLDHRTTVLPPRKDEAITLGPQGGLARGMSIRGQPLISNAELSSADSRRMVSGPNGYNSASTAREEPGSRIPDRSGRIAPNTQFAGPSNRPASQEGRSGNKLYSEDDLREKSISAIREYYSAKDEKEVALCIEELNAPSFYPSVVSLWVNDSFERKDMERELLTKLFVSLCNSRNNLLSKSHLTAGLATVLGSLEDALSDAPRAAEYLGRLLARFVVESILSLQEVGTLIEKGGEEPGELVHHGIGADVLGAVLESIKVEKGDSFLNEAKASSNLKLEDFRPQHLKRSKLDAFMKA", "function": "Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.", "AFDB_id": "AF-B9FXV5-F1-model_v4" }, { "swissprot_id": "Q9USL5", "sequence": "MKLIQKNIEKNGSGWITMCPEEPEDMWHLYNILQVGDQLKASTVRRVVKVGATGSTSGSRVVMKLRILVENMDFDTKAAQLHIKGRTTEYHPEVKMGSYHTLDLELHRNFTLYKNEWDAFALDRVDAACNPSRNAEIGAVVLDEGLANICLITDYMTILRQRIDQVIPRKRRGDSSAYQKGLDKFYDSVFQSINSEFDFDKLKVVILASPGFVARGLYDYIFSMAVKLDLKQIVKSKNKFVILHSSTGHIHSLNEILKDPAVESKLADTKYVQEIRVLNKFYDVMNEDDRKAWYGPNHVLKAFELGAIGELLISDSLFRSSDIATRKKWVSLVEGVKEINCPVYIFSSLHESGKQLDLLSGIAAILTYPVDEEDISEDEEDEESQNFEHS", "function": "Involved in protein translation. Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of hbs1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions.", "AFDB_id": "AF-Q9USL5-F1-model_v4" }, { "swissprot_id": "Q9LYE4", "sequence": "MSQHSNYQMTTASDYYSTKPVLSAIRSHKLISSVFEGKCPSDYESAWSPTSPLDFRLFSTLGNPFAASSSRSIWRGKQRSWDSGKVGLSIVHSLVDDHHTDSSATIVLPSPDSKNIIFGSLMRSGQKPHLLSQPFTKALMPKDVIPNAVFEIGHDVIDVLELRKSGSVDAAYCSGAENFSVNNNACQVTKQDPGSLNGGTESDMEISEDYTCVISHGPNPKTTHFYGDQVMESVEREELKNRCCKNEKESIFAVAPLDLTTPVDVLPPKDFLSFCYGCSKKLGMGEDIYMYSGYKAFCSSECRSKEIDLDEEMEDGDEEEAIKSVSSSDKESKKKSNGVFFTVG", "function": "May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway. Negatively regulates KIN10 leading to a repression of the SnRK1 signaling pathway.", "AFDB_id": "AF-Q9LYE4-F1-model_v4" }, { "swissprot_id": "O13828", "sequence": "MSFTNATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFYEDFIRAQNDQLPSLGLRVFSAKLFAHCPLLWKWSKVHEEAFDDFLRYKTRIPVRGAIMLDMSMQQCVLVKGWKASSGWGFPKGKIDKDESDVDCAIREVYEETGFDCSSRINPNEFIDMTIRGQNVRLYIIPGISLDTRFESRTRKEISKIEWHNLMDLPTFKKNKPQTMKNKFYMVIPFLAPLKKWIKKRNIANNTTKEKNISVDVDADASSQLLSLLKSSTAPSDLATPQPSTFPQPPVESHSSFDIKQKILHLLNEGNEPKSPIQLPPVSNLPLNPPIQSSNSRLSHDNNSFDPFAYLGLDPKNPSASFPRVVSQNNMLTNKPVLNNHFQQSMYSNLLKDQNSVQHLFAASDMPSPMELPSPSTVYHQVFYPPTSTSVSSYGLGKTPQPAYGSSSPYVNGHQTQQISSLPPFQSQTQFLARNSDNSGQSYNSEGDSNSKRLLSMLSQQDTTPSSSTLSKEANVQLANLFLTPNSLETKKFSDNSQGEEISDNLHGESCNNPNANSVHSAQLLQALLHPSATETKEETPKKTSDSLSLLTLLKSGLPTPANDLQNKSQNNERKASSQVKELEVKNYSKSTDLLKKTLRIPRNDEPLEAANQFDLLKVSPQQKSEVPPKRNELSQSKLKNRKKKENSETNKNHVDMSPGFVKILKRSPLADQKKEDTQESDFKGSDDHFLSYLQSVVSSNSNGLH", "function": "Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.", "AFDB_id": "AF-O13828-F1-model_v4" }, { "swissprot_id": "Q39592", "sequence": "MAAGLPPVQYSIDTDADLETRLAGKGLKVVEIFSEWCGPCKSVLPTFRRIRLDKDDENALLFLTVCAEKCNFLETAKEHRGKSEPLFLLYRNGQLKARIEGANTPALNQQVLSLTPANADVDDLEENPMYLAKMERERIARGETVKDAKGAKKGKK", "function": "May be involved in regulating the redox state of functionally important thiol groups within dynein.", "AFDB_id": "AF-Q39592-F1-model_v4" }, { "swissprot_id": "Q9SI61", "sequence": "MAATTSFSSSLSLITKPNNSSYTNQPLPLFPKPFLKPPHLSLLPSPLSSPPPSLIHGVSSYFSSPSPSEDNSHTPFDYHNDEDDEKPREECGVVGIYGDPEASRLCYLALHALQHRGQEGAGIVTVSPEKVLQTITGVGLVSEVFNESKLDQLPGEFAIGHVRYSTAGASMLKNVQPFVAGYRFGSIGVAHNGNLVNYKTLRAMLEENGSIFNTSSDTEVVLHLIAISKARPFFMRIIDACEKLQGAYSMVFVTEDKLVAVRDPYGFRPLVMGRRSNGAVVFASETCALDLIEATYEREVYPGEVLVVDKDGVKSQCLMPKFEPKQCIFEHIYFSLPNSIVFGRSVYESRHVFGEILATESPVECDVVIAVPDSGVVAALGYAAKSGVPFQQGLIRSHYVGRTFIEPSQKIRDFGVKLKLSPVRGVLEGKRVVVVDDSIVRGTTSSKIVRLLREAGAKEVHMRIASPPIVASCYYGVDTPSSEELISNRLSVEEINEFIGSDSLAFLSFDTLKKHLGKDSKSFCYACFTGDYPVKPTEVKVKRGGGDFIDDGLVGSFENIEAGWVR", "function": "Catalyzes the first committed step of 'de novo' purine biosynthesis from glutamine. Involved in plastid biogenesis and cell division.", "AFDB_id": "AF-Q9SI61-F1-model_v4" }, { "swissprot_id": "Q5W0B1", "sequence": "MAQTVQNVTLSLTLPITCHICLGKVRQPVICINNHVFCSICIDLWLKNNSQCPACRVPITPENPCKEIIGGTSESEPMLSHTVRKHLRKTRLELLHKEYEDEIDCLQKEVEELKSKNLSLESQIKTILDPLTLVQGNQNEDKHLVTDNPSKINPETVAEWKKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLVRENLRLKAEVDNRSPQKFGRFAVAALQSKVEQYERETNRLKKALERSDKYIEELESQVAQLKNSSEEKEAMNSICQTALSADGKGSKGSEEDVVSKNQGDSARKQPGSSTSSSSHLAKPSSSRLCDTSSARQESTSKADLNCSKNKDLYQEQVEVMLDVTDTSMDTYLEREWGNKPSDCVPYKDEELYDLPAPCTPLSLSCLQLSTPENRESSVVQAGGSKKHSNHLRKLVFDDFCDSSNVSNKDSSEDDISRSENEKKSECFSSPKTGFWDCCSTSYAQNLDFESSEGNTIANSVGEISSKLSEKSGLCLSKRLNSIRSFEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSLDLDGLSKSSQGSEFLEEPDKLEEKTELNLSKGSLTNDQLENGSEWKPTSFFLLSPSDQEMNEDFSLHSSSCPVTNEIKPPSCLFQTEFSQGILLSSSHRLFEDQRFGSSLFKMSSEMHSLHNHLQSPWSTSFVPEKRNKNVNQSTKRKIQSSLSSASPSKATKS", "function": "E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase.", "AFDB_id": "AF-Q5W0B1-F1-model_v4" }, { "swissprot_id": "Q7TMA2", "sequence": "MSTAPSLSALRSSKHSGGGGGGGGGGGSGGGSADPAWTSALSGNCSGHGPGSSPAGSTKPFVHAVPPSDPLRQANRLPIKVLKMLTARTGHILHPEYLQPLPSTPVSPIELDAKKSPLALLAQTCSQIGKPDPSPSSKLSSVASNGGGAGGAGNGAGGDKDAKSGPLKLSDIGVEDKSSFKPYSKPGSDKKEPGGGGGGGGGGGGGGGVAAEKSGFRVPSATCQPFTPRTGSPSSSASACSPGGMLPSAGGGPEGKDDKKDPEAGGGGSSKGSGGASADGVPAGLGHGRISCGGGINVDVNQHSEGGPGGKALGSDCGGSSSSSSGSGPSAPTSSSVLGSGLVAPVSPYKPGQTVFPLPPAGMTYPGSLAGAYAGYPPQFLPHGVALDPTKPGSLVGAQLAAAAAGSLGCSKPAGSSPLAGASPPSVMTASLCRDPYCLSYHCASHLAGAAAASASCAHDPAAAAAALKSGYPLVYPTHPLHGVHSSLTAAAAAGATPPSLAGHPLYPYGFMLPNDPLPHICNWVSANGPCDKRFATSEELLSHLRTHTAFPGTDKLLSGYPSSSSLASAAAAAMACHMHIPTSGAPGSPGTLALRSPHHALGLSSRYHPYSKSPLPTPGAPVPVPAATGPYYSPYALYGQRLTTASALGYQ", "function": "May function as a transcriptional repressor.", "AFDB_id": "AF-Q7TMA2-F1-model_v4" }, { "swissprot_id": "Q9US03", "sequence": "MEEEGHKSLTSHLPQSSSSLSQSREIAKEFTSNIPPPTIKTNSSSSNILKPRLSLQNEVNQLKPAKFPSKMLPPGSLASVKSSSLAKKARPFTASSNPRMPKSAHPISSRSVSASSHFGRPASAVSSSLNSSDDVRSMSDESMESYNDEKSVNASALRTTEDRLRSMEMAYAQLSAKVIPSPSKRPANYKFYEQRIAMLEESLEVERSRTSELQEQFSVALREKAEAEANKIVSQKGMESLEIMLNSMKSENHQRMAMLEENHARVMETAELQHQAELQDFASNIEQKANSLIMEYKNELQSAEEHFSHKIKELTSENELKISRLQEEKDSLLKKVQEGASLAMQRVQNKHDLEKKRLQSAIQPLQEENNSLKQQIEQLQRELASETVVKENLKSSLDQQSANVQKLESTNRALESTIKTLEEDVYTMKNKIIELEGILKSANVERDGLVEKLIAEETLRRKLHNTIQELKGNIRVFCRVRPPLGDGESAQIAFPDQNSEASTIEIVAQAPGSSLTGNGIKQYAFNFDRVFSPETTNEDVFNELSQLIQSAMDGYNVCIFAYGQTGSGKTHTMSSNTGMIPSSVRMIYNRSTSLKERGWEYRMEGQFLEIYNETIIDLLASGNEEEKGKKKLEIYHDTKAGRTTITNITSEPLDTPEQVTWLLDQASKNRSVAATNANEHSSRSHSVFMLHLNGSNSTTGETCRSTLNLIDLAGSERLSSSQSVGERLKETQAINKSLSCLGDVIHALGSGKEGTYIPYRNSKLTNLLQYSLGGNSKTLMFVNISPLKQHVPETLCSLRFATKVNNTQIGTARKVTK", "function": "Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle. Required for the polarization of interphase microtubules where it orients the microtubule plus ends toward the cell ends and the minus ends toward the cell center. Mediates minus end-directed sliding of cytoplasmic microtubules relative to each other, thereby promoting mitotic spindle disassembly.", "AFDB_id": "AF-Q9US03-F1-model_v4" }, { "swissprot_id": "A5DUG6", "sequence": "MYTYMEYLQKCFFKTTNWNEDNIFSNINATSQAILDFPIPNGLKVDSSSKTTDYLASSFTLSNFHLINGSLAYLYSLCPLTNTMGTKDVSLQDAIAGFRIIEPMITLRNQPVGPKTKKLRYSNKYNNNNNNNKNINNKKYAMKKDSRNSLLYGRMYFPGSALEAMVIKRINENTQLLVKCVSNPHLERNGTMIVYLQNNTMKYLRELIYSTNESLIGLRFLYNLGNPITKNISPALAPKFDNSVVSVGTELWFAARTMSPGLSTALRYSTRSTSTGKPLTMTLAVNPILGHISSTYTVKTSVASTFCSKYDFNFFSYASNLSLGFELYSYARNKNYLSPVESSMMLEQPTATVPGSLHNQATKPRRESQRQKSEDYISSSDSDYTRMQVKEFGPGGRITSEQKSNDRLPNKVSPIQNKRDRGREHFTNSSSNNSNSNINSNANTNLDAAFEEKVTTAFQNLVNASDFSSVVKVSTSLRDKTVKLLWEGRVKDFLVSTGARIAINPVTNAPEFSKFGINFSYAF", "function": "Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.", "AFDB_id": "AF-A5DUG6-F1-model_v4" }, { "swissprot_id": "Q8K9B7", "sequence": "MKEIYAIFGGNFDPIHYGHITSAEKLSREISIKKIILLPNYGPPHRSKTKTSIIDRLKMIKFAIKDNKLFTISYLETKKNTTFYTIETLKKIRKKIGYLQPLCFIIGEDNLNNLNIWKDWKKILSLSHLLICPRIHIKKSNPKLKKWISDHTTKNSNLLHKKPFGFIFFSKMSMLNISSTAIRKSYYEGKSACGLLPSKIDKYILSKNLYKIYNQN", "function": "Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).", "AFDB_id": "AF-Q8K9B7-F1-model_v4" }, { "swissprot_id": "P11934", "sequence": "AAAQRRQNDSSVFLAIMVAAAVESESSLTDGDAGALLLQDISEWDEVFRFDRLEAVERAAHAAAAAAFGAFVARGDWTASAAAAFQAAGKQIAFMAAFSTVAGAKGSATVRDADAFAAKFASAAALQELVGNNSPISFFIFDLLFAAILFASKAKAANQAAFAAAAELAAESLFVRLPSLHQVSFFALAGFAAVAAHRHMNGYGSHTFKLVAKDGSVYCSKFWYKADQGQAAEVWKDAEEVAAEDVDYFRDLNFQAEAAGRYPLWELASQVMTFSDFEIDPFNENIPTKVVPRESVPLIVDAELLLNRNPLNMFAEVEQVFMDVAAASKGADEVEDPLIQRQFAYIDTHLSELTASYGIPVCRPYATVLNDQEDGARYDDVQDVLVIAPNAFSASAVEVQIPAAAAFNLAAARVAAAGDVRVNAVVEADQRKQSRQFWASDVNAQKKRLVDAFRMEVASAVSASIQVDVTVEFSFVAAAAAARIAAAVGSAAAGALANRRQIKVIASLAVLAKADAKVRQKNALESSSQAVAVDAKAAAQDIVDSSDAANVVTVAREFAVLPQTAAADAAEFVAAASAKAFSSFPAMEVISVAAAAGAVAEPARASLDLNMAMFFSRIVASRGAAANAIAALVKASRDGVFVAAVLAKAAANNRAAEAIFKFEVRQAVDA", "function": "Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.", "AFDB_id": "AF-P11934-F1-model_v4" }, { "swissprot_id": "Q8WPP2", "sequence": "MDEPSNMSTTSSKIPQYDFYSDVDNLHPDQFRIQCLPGRNFISPLVEQKKDFVKAHVIHDKDLDIMYDPMPKGKCNISQSCLTLPLACPRVSLHFDPSKTTVAMVTCGGVCPGLNDVIRGITLAAVCSYHVKKVIGFKYGYWGLSKAGRHTAIELTSNIVRGLRHLGGTFLGTSRGGQNISDMVDTLVEYGVNILFTIGGDGTQKGAVAISEEVNRRGLDIAVFGIPKTIDNDLSFSQRTFGYETAVSEAVIAIRAAHAEAISHEYGVGIVKLMGRNSGFIAASATVASALSHICLIPEKNVSKKVLLSLIEARFMMAKDIVIVVAEGFGQDWPDCNEDLGSDASGNKRLTDIGLVIKKIVQDHLSKNPKYHQSTVKYIDPSYMIRACPASTSDAAFCSNLSTLAVHEAMAGRTACLITLWYSNFVLVPIKTAVSHRKIVSTGGALWRQVREVTVDGSGDIAMVHQQELSRELKAINAHRNSIMEQLSKL", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.", "AFDB_id": "AF-Q8WPP2-F1-model_v4" }, { "swissprot_id": "P26802", "sequence": "MELFTVNRYTEDLKEQKDGAQGTNNEDEILQKLLKKAAKRKRKHEAIEVVETPILEKETSDVKESESKEEQVEEPEKPLEVVQEEDVPSNEFQVLGGDDSAAKKKKVQMQLPNWLAHPTIIEGGSLQPEEEVPASEAIDQLDYLEKYTCQALKQMKIKRLFPVQKQVIPWILEAHAKPPPFRPRDICVSAPTGSGKTLAFAIPIVQLLSQRVDCKVRALVVLPVAELALQVYRVISELCSKTELEVCLLSKQHKLEDEQEKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRIMDAVFQNWLYHLDSHVKETTDQLLAGTQAPLCYAELQASFGKQPHKLLFSATLSQDPEKLQDLRLFQPRLFATVLTMPVLKDATEEGADTEALTDPGQFVGRYTTPAELTEQYCVTELRLKPLTVFALVEKYKWKRFLCFTNSSDQATRLTFVLKVLFQKYSTKVSELSGNLSAKVRNERLRDFAAGKINGLICSDALARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQDMTLFKKILSDANKGLGEEIHVSPDIEIQHAVEYKEALAGLRSEKVKNKNQKMAEKNRVATKALIHKKQEETATVRPLTLMEKLQIKANEIVQSSKKSSETKNSKTKADKTKYQPKETKKQIIAKQLKAIEN", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.", "AFDB_id": "AF-P26802-F1-model_v4" }, { "swissprot_id": "B0T0X6", "sequence": "MARSTVLTPEDEATPAVRHARWQDYFQLMKPRVMSLVVFTALTGLLAARTPIHPLLGAVAVLCIAIGAGASGALNMWYDADIDAKMRRTRGRPVPMGLVKGEEAATLGVVLSLLSVMLMGMAINWLAAGLLAFTIVFYAVVYTMWLKRWTAQNIVIGGLAGALPPAIGWAAATGHAPLNAWLMVLIIFLWTPPHFWALSLYISTDYAKAGVPMLPVVKGAKETRKQILLYSLALIPVCLAPAFTGLGGWLYLAVSGLGGLVFLTLAVRVFRSLAGEASDPRPADRDLYEVGEAAAKRGKPVGDAKHARNLFAFSILYLFALFAALLAEAVLGLPILNLHVLELPL", "function": "Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.", "AFDB_id": "AF-B0T0X6-F1-model_v4" }, { "swissprot_id": "B2JLI5", "sequence": "MDTIAFRMVLNRGMRDEYERRHREIWPELVSKLHNAGVRDYRIFLDDDTHHLFAVLTRTADHSMERLPELAVMRKWWDYMADIMQTAPDRTPLQQALIPLFELQHPSN", "function": "Involved in the anomeric conversion of L-rhamnose.", "AFDB_id": "AF-B2JLI5-F1-model_v4" }, { "swissprot_id": "O07638", "sequence": "MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYEEVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK", "function": "Essential for cell growth and for normal cell shape.", "AFDB_id": "AF-O07638-F1-model_v4" }, { "swissprot_id": "O87943", "sequence": "MSDVQTLEYKGKVVQFAPENPREAEIPADELHEHLQNPSTERTRRLKARCRWKHAAAGEFCEKGVTAGIERMRLLTESHWATRGEPEPIRRAHGLKNILDKSTLVLQTDEFIVGYHAEDPNMFPLYPELSYMAVQDYLKSKYSPQPAKEAQEIVDYWKPFSLQARCEPYFDPVDLHRGYQVSTIEGPVFATGYNSVIPPYETVLEDGLQARIALAEEKIEHARAEMEKFPWHAPSGLEWIDKIDNWKAMVIACKAVIAWARRHARLCKIVAEHFETDPKRKAELLEIADICQRMPAEPARGLKDAMQSKWFTFLICHAIERYASGFAQKEDSLLWPYYKASVIDKTFQPMEHKDAVELIEMERLKVSEHGAGKSRAYREIFPGSNDLFILTLGGTNGDGSDACNDMTDAILEATKRIRTTEPSIVFRYSKKNRAKTLRWVFECIRDGLGYPSIKHNELGVQQMLEMAKYSRNGNGATPEEAHYWVNVLCMAPGLAGRRKAQKTRSEGGSAIFPAKLLEITLNNGYDWSYADMQMGPETGYAKDFATFDQLWEAFRKQYQYAIALAIRCKDVSRTMECRFLQMPFVSALDDGCMELGMDANALSEQPNGWHNPITSIVAGNSLVAIKKLIYDEKKYTMAQLMDALQANWEGYEEMRRDFKNAPKWGNDDDDADVLISRFYEEILGGEMMKNINYSGGPVKPTGQAVGLYMEVGSRTGPTPDGRFGGEAADDGGISPYSGTDKKGPTAVLRSVSKVQKNQKANLLNQRLSVPIMRSKHGFDIWHAYMDTWHDLNIDHVQFNVVSTEEMKAAQREPEKHQDLIVRVSGFSARFVDIPTYGQNTIIARNEQNFNAQDLEFLNVEL", "function": "Catalyzes the addition of fumarate to the methyl group of toluene, leading to the formation of benzylsuccinate.", "AFDB_id": "AF-O87943-F1-model_v4" }, { "swissprot_id": "Q8EEB1", "sequence": "MPGFELFGPEEKQEVADVMEHGFTFRYNFDHMRNDRWKTRDMEQLLCEKMNVKHAHLLSSGTAALQTAMMAAGIGAGDEVIVPPFTFVASVEAIFMAGAVPIFAEIDETLCLSPEGIEAVITPRTKAINLVHMCGSMAKMDEIKAICKKHNLVLLEDACQAIGGSYKGQALGTIGDVGCYSFDSVKTITCGEGGAVITNNTEIYDNAHMFSDHGHDHIGKDRGAESHPIMGLNFRISEMNAALGLAQLRKLDTIIDIQRKNKKAIKDAMASIPEVSFREIPDPEGDSAGFLSFMLPTEARTQEISKKLAANGVDGCFYWYVNNWHYLKNWKHIQELKAPAALPITLIADRPDYTQISVPKSDAIMSRTISMLIKLSWTDAQIAERIENIKKAFAQ", "function": "Catalyzes the second (last) step of the biosynthesis of Kdo8N (8-amino-3,8-dideoxy-D-manno-octulosonate) from Kdo (3-deoxy-D-manno-octulosonate).", "AFDB_id": "AF-Q8EEB1-F1-model_v4" }, { "swissprot_id": "Q9VG74", "sequence": "MLLNDIISGKLVDSVYIIAEIGQNHQGCVETAKKMIWEAKKAGCHCVKFQKSDLPAKFTRSALDREYISDHAWGKTYGEHKEYLEFSKDQYLQLQAHCKELNVDFTASAMDERSLEFLSALNVPFIKIGSGDANNFPLLKKAANLNLPLVISTGMQTMQTVERIVQTMRESGKEDYALMHCVSSYPTDPKDCSLQLISVLRTRFPNVAIGYSGHELGVIISQAAVLLGARIVERHFTLDKSQKGSDHRCSLEPQELKALTTAITNFKLSSVPMPPQEIVKKLNGDEELEAALQHVESKTILPCELPCRNKLGKSIVAARNLNKGYRLQLADMAIKVSEPSGLTAEDFLDLVGKELADNIGEDEPILGNSIIN", "function": "Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system.", "AFDB_id": "AF-Q9VG74-F1-model_v4" }, { "swissprot_id": "Q08204", "sequence": "MTSLIDLGRYVERTHHGEDTEPRSKRVKIAKPDLSSFQPGSIIKIRLQDFVTYTLTEFNLSPSLNMIIGPNGSGKSTFVCAVCLGLAGKPEYIGRSKKVEDFIKNGQDVSKIEITLKNSPNVTDIEYIDARDETIKITRIITRSKRRSDYLINDYQVSESVVKTLVAQLNIQLDNLCQFLSQERVEEFARLKSVKLLVETIRSIDASLLDVLDELRELQGNEQSLQKDLDFKKAKIVHLRQESDKLRKSVESLRDFQNKKGEIELHSQLLPYVKVKDHKEKLNIYKEEYERAKANLRAILKDKKPFANTKKTLENQVEELTEKCSLKTDEFLKAKEKINEIFEKLNTIRDEVIKKKNQNEYYRGRTKKLQATIISTKEDFLRSQEILAQTHLPEKSVFEDIDIKRKEIINKEGEIRDLISEIDAKANAINHEMRSIQRQAESKTKSLTTTDKIGILNQDQDLKEVRDAVLMVREHPEMKDKILEPPIMTVSAINAQFAAYLAQCVDYNTSKALTVVDSDSYKLFANPILDKFKVNLRELSSADTTPPVPAETVRDLGFEGYLSDFITGDKRVMKMLCQTSKIHTIPVSRRELTPAQIKKLITPRPNGKILFKRIIHGNRLVDIKQSAYGSKQVFPTDVSIKQTNFYQGSIMSNEQKIRIENEIINLKNEYNDRKSTLDALSNQKSGYRHELSELASKNDDINREAHQLNEIRKKYTMRKSTIETLREKLDQLKREARKDVSQKIKDIDDQIQQLLLKQRHLLSKMASSMKSLKNCQKELISTQILQFEAQNMDVSMNDVIGFFNEREADLKSQYEDKKKFVKEMRDTPEFQSWMREIRSYDQDTKEKLNKVAEKYEEEGNFNLSFVQDVLDKLESEIAMVNHDESAVTILDQVTAELRELEHTVPQQSKDLETIKAKLKEDHAVLEPKLDDIVSKISARFARLFNNVGSAGAVRLEKPKDYAEWKIEIMVKFRDNAPLKKLDSHTQSGGERAVSTVLYMIALQEFTSAPFRVVDEINQGMDSRNERIVHKAMVENACAENTSQYFLITPKLLTGLHYHEKMRIHCVMAGSWIPNPSEDPKMIHFGETSNYSFD", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.", "AFDB_id": "AF-Q08204-F1-model_v4" }, { "swissprot_id": "Q67TC3", "sequence": "MTTFLFSLAEASGGKEFHIHQPFPVLLQGTYFEINNMIITQWLIVAGLLALAFVINRAVLSGRPSKLRGSLELLIDFLEGWFASFIGSRQYARQYMPLLCTLFLFIIVSNYLGVVPTVGYGLFAPTGRWGTTLGLGIVVAIAVQVIAIRTLGAGGWLKHILHLGPLSLLEEIVHPFSLSLRLFGNIFGEETLLAVIIFLAPMIAPIPIMVLSLVFGALQAVVFTTLTAIYIGAVLEHHQAHAHHPEGEAEHEPAPAH", "function": "Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.", "AFDB_id": "AF-Q67TC3-F1-model_v4" }, { "swissprot_id": "A1TSE0", "sequence": "MSDPTEHPEILQDPSSSAPVQGRTDLPPGWLEVTSMDMDAQGVARRPDGKVVFIDGALPFEWVSASTHRKKNNWEQASLTAIHRESPQRVRPGCPHFGLHAGACGGCKMQHLHVGAQVAVKQRVLEDNLWHLGKVKAETVLRPIEGPAWGYRYRARLAVRHVEKKGKVLVGFHERKSRYIADMEVCPVLPPHVSAMLLPLRALIASMDARDTCPQIELACGDDVTALVLRHLEPLSEADLGRLRSFAAAHGVQWWLQPKGPDTVHLLDEGGPQLNYALPDFGITMPFKPTDFTQVNPHINRVLVTRALRLLDAGRTDRVIDWFCGLGNFTLPIATQAREVVGIEGSEALVARSRENYRKNQDDRPQGQALAPATFVARNLFEMTPEMLIADGVADKWLVDPPREGAFALAKALADIHQARIGAEDAPALPASAEGWTPPQRIVYVSCNPATLARDAGLLVHQAGYRCVAAGVVNMFPHTAHVESMAVFERV", "function": "Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.", "AFDB_id": "AF-A1TSE0-F1-model_v4" }, { "swissprot_id": "P58056", "sequence": "MYQPQPFVTRLAFKCSDRPEAQEARERLAARYGDVGPENAQVIVALGGDGFMLESLHEAIASQTPIYGMNRGSVGFLMNEYSEDGLLERINAAERAVIHPLAMVAIDARRTQHRALAINEVSLLRQTRQTAKLRISIDGKVRMGELVCDGALLATPAGSTAYNLSAHGPIIPIDGRVLALTPISAFRPRRWRGALLPQSARVTFEILEADKRPVSAVADNFEVRDAMEVHISEDRGTSLAMLFDAGRSLEERVLAEQFSA", "function": "Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.", "AFDB_id": "AF-P58056-F1-model_v4" }, { "swissprot_id": "O13563", "sequence": "MSMSSTVIKFRAGVCEYNEDSRLCTPIPVQGEIEIKPNEEEELGFWDFEWRPTEKPVGRELDPISLILIPGETMWVPIKSSKSGRIFALVFSSNERYFFWLQEKNSGNLPLNELSAKDKEIYNKMIGVLNNSSESDEEESNDEKQKAQDVDVSMQD", "function": "Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.", "AFDB_id": "AF-O13563-F1-model_v4" }, { "swissprot_id": "Q84BZ0", "sequence": "MSADPFVIVGAGHAARRTAEALRARDADAPIVMIGAERELPYDRPALSKDALLNDDGEQRAFVRDAAWYDAQRIALRLGTRVDAIEREAQRVRLDDGTTLPYAKLVLATGSRVRTFGGPIDAGVVAHYVRTVADARALRAQLVRGRRVAVLGGGFIGLEVAAAARQLGCNVTVIDPAARLLQRALPEVVGAYAHRLHDERGVGFQMATLPRAIRAAAGGGAIVETDRGDVHADVVVVGIGVLPNVELAQAAGLDVDNGIRVDAGCRTADRAIFAAGEVTMHFNPLLGRHVRIESWQVAENQPAVAAANLLGADDAYAELPWLWSDQYDCNLQMLGLFGAGQTTVVRGDPARGPFTVFGLGGDGRIVAAAAVNLGRDIGAARRLIAAGAMPDPQQLADPTVGLKTFL", "function": "Part of the multicomponent anthranilate dioxygenase, that converts anthranilate to catechol. Probably transfers electrons from ferredoxin (AndAb) to NADH.", "AFDB_id": "AF-Q84BZ0-F1-model_v4" }, { "swissprot_id": "G5EG44", "sequence": "MEQQLNLGHLLTAARLLDIGALDISSLDLGALTSTSSSPGSSSPAMFDLSNESELRSLFCGKLKVDKKQSSCASNASTSSQPYCSSPPARKSSKHSRTAHNELEKTRRANLRGCLETLKMLVPCVSDATRNTTLALLTRARDHIIELQDSNAAQMKKLNDLRDEQDELVAELAQLQADEEVAQATSQACQTLSQSRPESRASSFTSTSSRDSPCYLEYSPSSKPMDSHKPTIIDLYAEGLIPRGPITFPRPLVYPHNVFDLMNLPPTPFDVSQFLPINLQV", "function": "Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mxl-1. Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and may overlap with the insulin-like signaling pathway. Plays a role in autophagy. Involved in promoting infection by the microsporidian pathogen N.parisii, possibly together with transcription factors pha-4 and zip-10.", "AFDB_id": "AF-G5EG44-F1-model_v4" }, { "swissprot_id": "P40381", "sequence": "MKKGGVRSYRRSSTSKRSVIDDDSEPELPSMTKEAIASHKADSGSSDNEVESDHESKSSSKKLKENAKEEEGGEEEEEDEYVVEKVLKHRMARKGGGYEYLLKWEGYDDPSDNTWSSEADCSGCKQLIEAYWNEHGGRPEPSKRKRTARPKKPEAKEPSPKSRKTDEDKHDKDSNEKIEDVNEKTIKFADKSQEEFNENGPPSGQPNGHIESDNESKSPSQKESNESEDIQIAETPSNVTPKKKPSPEVPKLPDNRELTVKQVENYDSWEDLVSSIDTIERKDDGTLEIYLTWKNGAISHHPSTITNKKCPQKMLQFYESHLTFRENE", "function": "Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes.", "AFDB_id": "AF-P40381-F1-model_v4" }, { "swissprot_id": "Q9NWM0", "sequence": "MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT", "function": "Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.", "AFDB_id": "AF-Q9NWM0-F1-model_v4" }, { "swissprot_id": "D4AY62", "sequence": "MLSLIVACLVLPLICYKLVRSYNQSREDEQFAASKGCQPPRKWSAKWPLGLDMLVKAVRYEKRQQILQLFLEEVAASGSTFEQNLLFARGIDTVEPRNIEAILSTQFTGSGIFTQDGPQWKHSRELLRPQFMTNRFRNFEQIRHAVNNLISSVPDSGVVDLQPLFFRLTFETTLFLLFGHYLPSLKSEGITGHESQFANAFNLGQDYLAQRGRLGDLYWLLGGREFKDACKVCHDFIDNAVQKALKHSSREKKVSDEEKETYVFIDALVQETREPSVLRDQCLNILLAGRDTTACCLTWTLRLLVQHPDVLSKLRDEVRDTIGMGPDAPDPTISQVKKLSYLSLVIKEVLRLYPSVPVNSRAAVKTTTLPTGGGPDGSAPLLVRRGEAVGYCVYAMHRRKDIYGPDADCFRPERWENDALKDVGYGYLPFNGGPRICLGQEFALLEVGYTVVRLLQTFETIEEAETKVPGAPLGEEKQTLTLVVSSGEGCWVSMKKGTK", "function": "Together with an NADPH cytochrome P450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.", "AFDB_id": "AF-D4AY62-F1-model_v4" }, { "swissprot_id": "Q8IWU6", "sequence": "MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQCNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG", "function": "Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.", "AFDB_id": "AF-Q8IWU6-F1-model_v4" }, { "swissprot_id": "Q5A0E5", "sequence": "MLYQQSYPITNKLLNASAAGSTSTASIIDGGCTLSKPGSGKTKSTTSLPSFNELLTSIPLPNEFKPSTKNTNQAAAATATSPYNYYMGPPAQHRLPTPPPYPMSSPTTATAATPLSQQSPHLQPQQTLQQPQPYHQQYYNYQYAAPPYPHPSQVPPPASYQQRHQQPMYQNTNGVPIIIRPSPGLITPTSTTFDHAKIRSNSTGDLSANSLALSSNNNTQSKDPRRKHVCKVCSRSFTTSGHLARHNRIHTGERKHQCPWPTCEARFARQDNCNQHYKTHTNGKNKRNRQQHRTLEASHVGTKYNTKSLV", "function": "Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament-specific gene expression in response to inducing conditions. Plays a key role in biofilm formation and dispersion. Also plays the role of a negative regulator of virulence in mice models. Required for the expression of the cell wall genes RBR1.", "AFDB_id": "AF-Q5A0E5-F1-model_v4" }, { "swissprot_id": "Q8SUE9", "sequence": "MTRRFTMTPNSRNPVKTPVSGMKVAPFPRHSIATEEVRRRDMRVVREKGYRQQCVDGILRFLVENGYDGQVSQKILHNPSSKDFQSIFKFLYGFVDDFTFSSRFEDEVVNVMKNLKYPYCGEITKSQLSAITPHTWPVILSMCSWLVDLISHGTSLLQQEEERSVESCFFEYVCDGYMRFMEGDEDDTALEEEFERRVTEIYTGIFKEIDRKKEELRRIEEMISEARKMSEGREELDRKKRELTDDLNMLIASEKQLEGKKRKYLGAISRLSEEIVKVEEEIESLRAQEDGLRAQITKQRINPEDVKEMNAEKIELFKELERMKPEKESLMKVVGEQEREAQERAEEVEKLFFDLKGLRDEISLRIVKDGKGVPRVANEVSGEVFSGMSGVIVRLEEELNSKSDVLVTAEMNKSILEEARGEKESITSELNSRLGYYSDKLVMAGKLYLEKKEISENEQRKSKTEMELLENELLKLNLESNTSLLMSEQKLQKARIVLDRTLNSINYEREEINKMIFGFYNAAMDIHASIQSQVGDLRALLNK", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.", "AFDB_id": "AF-Q8SUE9-F1-model_v4" }, { "swissprot_id": "Q3AIG9", "sequence": "MRPRPCSILSLDVGRRRIGLAGCDALGISVTPLAALRRGRFDADLVVLQAHCCERSVQGLVVGLPLDAAGQPTAQAEHCQRYGLRLAAALDLPLAWVNEHSSTWAAGEQFGLKGDRSGRLDSAAAALLLEQWLAEGPELKPAQQTASRSGAGAGDGGS", "function": "Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.", "AFDB_id": "AF-Q3AIG9-F1-model_v4" }, { "swissprot_id": "Q12362", "sequence": "MEDSNNEASDDFNNLLNKEIESAKEVKLRKFANRNNNRNENSSKVKDASGFRLRVIQTDGHKTKKTDPDYEVTIDGPLRKIEPYFFTYKTFCKERWRDRKLVDVFVSEFRDREPSYYSKTIAEGKVYLNDEPANLDTIIRDGDLITHKVHRHEPPVTSKPIDIVFEDEDILVIDKPSSIPVHPTGRYRFNTITKMLERQLGYSVHPCNRLDKPTSGLMFLAKTPLGADRMGDQMKAREVTKEYVARVKGEFPIGIVEVDKPVRSVNPKVALNAVCEMSDENAKHAKTVFQRVSYDGQTSIVKCKPLTGRTHQIRVHLQYLGFPIANDPIYSNPDIWGPDLGRGGLQNYDDIVLKLDAIGKTNPAESWIHPHSEGEYLLGRQCEECEAEMYTDPGTNDLDLWLHAFRYESLERNSDTQKPLWSYRTKYPEWALEPHRRYMEMAVKEAGKCGPTKTAFSVGAVLVHGTQVLATGYSRELPGNTHAEQCALIKYSQLHPNCPTIVPMGTVLYTTMEPCSFRLSGNEPCCDRILATQGAIGTVFVGVMEPDTFVKNNTSLNKLESHGVNYIQIPGYEEECTIIAFKGHDNSDDKA", "function": "Involved in riboflavin biosynthesis. Converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate.", "AFDB_id": "AF-Q12362-F1-model_v4" }, { "swissprot_id": "P60860", "sequence": "MYRPDIDLSSSGTMDTVSPTPASPMAGIDLRGAELTAARLRSALPRGGADVETVLPKVRPIVQAVAERGADAALEFGASFDGVRPAAVRVPEAALDKALADLDAAVADALRVMIDRARAVHADQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVASLVVASPPQAQFDGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTGAEWPGFSSDRARSASSPGADAELVPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAHVAADLISQAEHDEMAGSVLVTPSEDLAAATDAELAAQLPTTVHRERVTAALGGRQSAIILVDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVFVGPYSPVSLGDYCAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVITLAQAEDLPAHGEAIRRRFER", "function": "Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.", "AFDB_id": "AF-P60860-F1-model_v4" }, { "swissprot_id": "P40464", "sequence": "MVDHQWTPLQKEVISGLSAGSVTTLVVHPLDLLKVRLQLSATSAQKAHYGPFMVIKEIIRSSANSGRSVTNELYRGLSINLFGNAIAWGVYFGLYGVTKELIYKSVAKPGETQLKGVGNDHKMNSLIYLSAGASSGLMTAILTNPIWVIKTRIMSTSKGAQGAYTSMYNGVQQLLRTDGFQGLWKGLVPALFGVSQGALYFAVYDTLKQRKLRRKRENGLDIHLTNLETIEITSLGKMVSVTLVYPFQLLKSNLQSFRANEQKFRLFPLIKLIIANDGFVGLYKGLSANLVRAIPSTCITFCVYENLKHRL", "function": "Transport of FAD from the cytosol to the mitochondrial matrix.", "AFDB_id": "AF-P40464-F1-model_v4" }, { "swissprot_id": "Q9M4A2", "sequence": "MEGKFAISESTNLLQRIKDFTQSVVVDLAEGRSPKISINQFRNYCMNPEADCLCSSDKPKGQEIFTLKKEPQTYRIDMLLRVLLIVQQLLQENRHASKRDIYYMHPSAFKAQSIVDRAIGDICILFQCSRYNLNVVSVGNGLVMGWLKFREAGRKFDCLNSLNTAYPVPVLVEEVEDIVSLAEYILVVEKETVFQRLANDMFCKTNRCIVITGRGYPDVSTRRFLRLLMEKLHLPVHCLVDCDPYGFEILATYRFGSMQMAYDIESLRAPDMKWLGAFPSDSEVYSVPKQCLLPLTEEDKKRTEAMLLRCYLKREMPQWRLELETMLKRGVKFEIEALSVHSLSFLSEVYIPSKIRREVSSP", "function": "Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.", "AFDB_id": "AF-Q9M4A2-F1-model_v4" }, { "swissprot_id": "A1RX33", "sequence": "MSTGTSASYKRDNAFYALDKVERILLDGYSLCDACTGRLFGLRGYGLSNTERGRALKTLLIMKAFQASPRQADLELLRVLARTGFEPARELLKKLSGEDVEVKACSICEGLTGRYYELALRAVEEAKSYEFNTFEVGVRIDAEVIRREEELWRRYGLESAESIRNEASREVGKIISKLTGKEYSRNNSELLIIVDLSAGAIELHPAPVFVYGRYRKYARGLPQNPWPQPDERIKFNTSIEELIVKPALELFEAEKAKFHAAGREDIDVRTLGTGRPFVLEIKKPRKRNIDLKVLAEKINSGAGGLIEVLDLAYTDRKTIKKLKSLASIAKKAYVARVKFEKPVDDEKLAEISKVFSNAVINQRTPTRVLHRRVDKLRKKIVYRLEARKISQDEVEFYLETQGGFYVKEFIHGDNGRTTPSIAEFLGNNVLSIELDVVSIEETAA", "function": "Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.", "AFDB_id": "AF-A1RX33-F1-model_v4" }, { "swissprot_id": "Q8I6K0", "sequence": "MWLSLVILGVASAIVNVSTQESCTTPNGETATCLPIESCKIFWDYVVTSGADPEINSFLRASLCRQGNYVVCCGSTLKFNSALPDRTECGLQDDFKVLGGEDTDLGEYPWMALLQQTKTSGAKSFGCGGSLISDRYVLTAAHCVVSSSYTVTMVRLGEWDLRATQDCVGSGSYQYCSPPPQDIGIESITSHPNYEKSSRGVFNDIALIRLARPVNRNKYVQPICLPLPTERTPVGENLLVAGWGATETKAQSDKKQKLKLPVTDLPACKTLYAKHNKIINDKMICAGGLKGKDSCKGDSGGPLFGQTGAGNAQFYIEGIVSYGAICGTEGFPAIYTRVSDHLDWIKQNVRV", "function": "Serine endopeptidase which, by cleaving prophenoloxidase activating factor PPAF2, is required for the activation of the prophenoloxidase cascade probably following the recognition of pathogen-derived products.", "AFDB_id": "AF-Q8I6K0-F1-model_v4" }, { "swissprot_id": "A5YVF1", "sequence": "MSFSKWGGKPSNSSEKQKASSTPTVEEINRGVGDIGLNSEQNEGWEVYARKPKNKGGSSAGKQWAPQNPSPKAWGNQNTKAWGHPDVGKKSGTRNNAGSGRGSGNNWSTPSDPQKLARPHLYDGGFPSSAPVPPALKNGWDWSSRVASAHPKDNSQVAAAADDDKASEHDAEDNELDFLDESDDDLHSDDFDSDVGEMSYETRKKNPWFNQLFHSLDSLTVTEINEPERQWHCPACKGGPGAIEWFTGLQSLMTHAKTKGLRVKIHRELAELLEEDLRQRGTSVVPPGEVYGRWGGMEFKDKEIVWPPMVIIMNTRLDKDENDKWIGMGNQELLEYFSSYAAVKARHSYGPQGHRGMSLLIFEASAVGYIEADRLSEHFSENGRNRDAWERRSARFYPGGKRLLYGYMADKKDIDNFNQHSAGKSKLKFEMRSYKEAVWNPAKQMREDNQQLIWFKNKAAKHQMQAKALEESLSLVSEKHRQTLEENKIVRLKTKMHHEQIKEEMEFQEQFFKDQIKIIHDARTAREDNFEKTQQEQREMVKQSNANTASVEDHRVRAEKVAKFIKLQDKEMEEFVEERENLMRTHDDRIAALRRKYWEEEVELERKFDLELSKLMEKYSPKQSDEVNSSGTM", "function": "Required for post-transcriptional gene silencing and natural virus resistance.", "AFDB_id": "AF-A5YVF1-F1-model_v4" }, { "swissprot_id": "Q9HNE6", "sequence": "MGASPVALTPLTARARRTLARPALALGWVAISIAALPAITGVSLSPTARYAPLVASAVVFGMPHGAIDYLALPRAVTGTVTVRWLAVVGVLYLVLGGGYAAAWFFAPVPAAFAFVAITWLHWGQGDLYPLLDFLDVDYLDTRPRRAATVLIRGGLPMLVPLLGFPERYRSVVDAFAAPFGGSVGDLAVFDPRVRLWLGVAFAAATVAVLAAGRRRTHSPGAWRVDAAETLLLWVFFFVVPPVFAVGVYFCVWHSVRHVARAIAVDGSVHPSLRAGDILGPLARFGVEAAPMTAAALALGGVLWWAVPNPPTTLESGAALYLVLIAVLTLPHVAVVTWMDRVQGVL", "function": "Appears to partially substitute for Brp function in retinal biosynthesis during bacteriorhodopsin production. Probably catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.", "AFDB_id": "AF-Q9HNE6-F1-model_v4" }, { "swissprot_id": "A1Z8X3", "sequence": "MSTKQSPALQLAEGQLTKLTSESEEIRMRALDQIETRFIRCLQLGEPIQFKPVLLLKQLIRWFGYTPPLVPDRVLAMIMELLRSEYAEAVIRKIPYERFKAELQKVRRVLHKQESKRVSELLDDMNLLLLEKYNIDRVTPSVSSLSSNDIPSQATESADSSSNQIYDNLKPEDYEPSWSHPCLDDVATMKSMIDLPRNSVELQLQLTELIIRMGDYPTEYFLQPPFVFLHLVQLQTMTDGSLIHVNRALIACLRLLQQRILLRRNTLSYADRFDPPSRPKQVKVVSALVILLENCMKLIRPLLFSCTNDNWHIMELIVEIVRTHDVLSSKIPLVSITLIADAVKSLLAYCNSVEGSCMTQLMDSLRIPRLQSLILNGVLHDMVALNINYDKRMDRRQAKALIQPIVLDSAYLSGMPERMKSLNTLISSLDSGPSPDEELIKLKRAYSVALNQLHPNTELTGSLLIQKYRQVCLVLVQLGSETLVKQLFGAVVKCIPFYAGNLKLRKDADELLYTLVDLPALKLRSLIYRLMIKSTVAHFHSFMNKTVYMTGCSNVDLIRQHILGVPLTPLLLRRMIIQSSEANTSERMQQWCLDYPIMIMKLNAILAPQDFSVVFPLLLPVLPLLISRSVTHKILHNVIWNVLEPDSSRLDPQLMLRGYVYFMFHPDGEVRSEATTTIAYVLQCQEQTNRYLPTASNVPVEHIANDLCIIQPPFCYRSIFIKCSDERFQGQRSLDALFRLLQAKDIKSNIRKSTMTQLNVLLRNWRACEEFSTKEDGYRLIMESLHNALKKGNDTDILLPTVSILMKLLFNDDEFRLEVANTFGVYTLLLRALFLFPHLEQLRQDVSICLFQMLFQNCITSTEDKLVLNANMEPLILPVTYEIEHKVIPTAVTEGLELQQNVEATHFGRDRAKAAQHWRLYMAYRVCQVPSSITLESVSALDIRESLKIKMADLALVRSSDLNEQLSCQFIAAENCSKHEDLQKTVSAIQLFLVVLRNSLSDTVAENLWKLIHKYIRLAPGNEADDKVYKSMLDLCVTCIRFSQPHAINGLSYALETDHHHSFQLLLHDSQISLDKLFLICQCMMQLLSNELSDDSMNWYGKFFMQLSAVAKTHFELRQLQHVRCILCMLRFVSERNLKFSNAQLMSYSQHFIQLSSNLRTSTQTGSEWQRDCLYIICQLQIHLIYQEPKASSKASIPNDVGASYKVLRYFLTLCGHGDSEVRALSWVSLANWITICGSQVAEILPRLDFLPGGLPACCLTTLTDAHEMMLIRELAGRVFILLMPLIGAESSLELLRKHDLLKTAYNSLKAIHDTPWMFKKIVGERHSCEVISCYVAICTKMVAMKPEWCAALCGHSLMSGLSDVMKKLKSQASCSIPLVELCASQICELYSMCYTNNFEFLKMTICRDSVFLQNYLTLINDVLSLECPEYMVIPLLKMFLIFCTDSNSNSFLIEQIKNKPSLFMDFFLFGLHVKLINSPFQRFTLSALSLVFTKAQLAAYDISMLSELEKFELAFSDPDIAKDGKQEFESKKKQSVSQCIYDESSDNSDDNKQRPNHAIQATNAAIIIFHRLDQLFDRYYLSKALNFLELPAVGQVQVCEALGELLKASTWAVKAAGESKLLGKVVHILDDFLNDEKIGNAAVYVKRVGPHKAQSIISNLLVLINMLSQWHSSPNSEIIQTSMAANIAKILIRIWPWLSHSYHLKKVTVQLIMFLTEHSFEMCKQISLLQSGHAQSLLHLMARVADFETTKKEIPNKEPSLNMVPALRVMVNCCCCTEGRLSLSKMNLLDMFDTILPANPCSTHLKVRPPVLIAWLGFWEVFSRYDVGGKACHLQSLINTIRRSPPLSHKRILCLRILRNMCFFNGNRPRLVELADFINLLRDILEQRVQKAPTSEKNGLNSFEEHRLAVLMLWKLFGFGAKYKGMLRGTKLFKLLIGLRVEMSVVFSEEENKYAGVPYANDLAKLLEKLMESMRQ", "function": "Participes in the structural integrity of both centrioles and basal bodies and in centriole cohesion. Participates in the later stages of centriole assembly through the interaction with Rcd4 leading to the centriole to centrosome conversion.", "AFDB_id": "AF-A1Z8X3-F1-model_v4" }, { "swissprot_id": "Q6CRH6", "sequence": "MSVQFIVLFRDDDDNKDDSCKLLLYHDLTAHMLSTNEKEQKIGIIKGMWRFSNEFSQSNDYCHVELDSYSMLVLEVEPSYYLALGFENTHNSQWPKYKVRLSQCYQFFAMQHGKMQDIEDKTLSGLLNEHFIPFWDEINLIPDYFLMQDINTAIDDKMFPCCQFADALNSISEVKDWQNYLKNNVLLSEENYLNIKDVCVYHLPKNNKNTKEYGFITNFDPQFKSLPTLSNWLVGIDSMYGTVSSHGLAGTMSLTETEQQIELDAEEAHHEQPPNIKTVWDNVTLPITFTMDALKDIGQLTGVSNSLSLFTNMKPSWNLWSSSSENGAGSAKLDDKDEYSWLISPLNPSFLPKVYQMRKFYLQFDDWSQYNILFWKFKDVIVAVIVDPSFKKISEESFLMKLQEELWNGISLFYENTGFEKRQCSFDYTILFKEEGKYYSSIPRWKNGLDESDTALKLVIKGLDETLQFLTNNANRKSSVATVTEVGHDMSLTDHPIPSDPSKGEDGTEKTDKSESSIFSKLNESQLVELNKELMVILGTRSLTVWYKDANTKERMLKLNNGLMVYLLENNRKLVLIIKNWFIDSQQKTKSKRSTDMIESLGKDVSTWWNRIKDHEPL", "function": "In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.", "AFDB_id": "AF-Q6CRH6-F1-model_v4" }, { "swissprot_id": "Q9SEU4", "sequence": "MRGRSYTPSPPRGYGRRGRSPSPRGRYGGRSRDLPTSLLVRNLRHDCRQEDLRKSFEQFGPVKDIYLPRDYYTGDPRGFGFVQFMDPADAADAKHHMDGYLLLGRELTVVFAEENRKKPTEMRARERGGGRFRDRRRTPPRYYSRSRSPPPRRGRSRSRSGDYYSPPPRRHHPRSISPREERYDGRRSYSRSPASDGSRGRSLTPVRGKSRSLSPSPRRSISRSPRRSRSPSPKRNRSVSPRRSISRSPRRSRSPRRSRRSYTPEPARSRSQSPHGGQYDEDRSPSQ", "function": "Involved in intron recognition and spliceosome assembly. Binds to multiple 5'-GAAG-3' repeats found in its third intron, suggesting autoregulation of alternative splicing. May be necessary for accurate splicing of the 3' region of introns.", "AFDB_id": "AF-Q9SEU4-F1-model_v4" }, { "swissprot_id": "Q9VXG1", "sequence": "MCDAAAATATTTTTAAVAAAVATTTASVALEATATQPGTTTTTVATASAGTTSPEAAIPTAATATSARNSNSERSARQNCCRLCIAPQTECISIINSYAADKEPLSTKIHNCVGIKVTPQDRLSQQICHACISYLNSWQSFKNRCFSSQAKQRQWLDTNKSKLLNYLDLNSAENGGGGFFDQHLHQQQQHHQHLENELEAEKEKATPTAASTAANILDGIHSLKKRKSLTVYPLPAMPIKDEPIDTDDDYQMKSIDESDDMVDPTMFLERSEHEGDVPLTASDYDYTAQHGVNASSVAASLPPNAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPHNTPITKPTPALAAALEMQRAAAAAATAEANRAAGAAGGNISTQKYRQVVMNAFIKCEGGGYDYDNPEQYRPLLTRDKVEFIEQNDEFLEQYQTMTCRCCNKYFSTYKNFMAHVRKKYPQLPRNLCFNCLKMNDSKALFISHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGMARSNSMEHSPGKRSLLGALGVGSSAEESRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHLKEEVIVPVATKAAIERTAAMESAAADANAAATLSALGEGAETEDQFAEKVEAAGATTTDKLTNPDEEDSDDLDEDSSGDDDDSSGTGDDDDDDDSDDDEDGEGEDEDEEGDGGEGEDEEGVQPPAQLLPQQQHKTDLNLNQDDDDLVEEVISSDDDEDDDGEVESDDDDEDDDDEEDDVEEPEPVGLTVRPLMNGKSKMPPLIVASSDDEDDGVMPIEDIIEEEFDEDADPDPEDAIEEVDEDDLDEGEVEDEPNVVSTASFSESESSTTTTSNSHSHSHSTGERRKKAVDQLNDPGFTCDLCQLCFDSQELLQSHIKSHILNGPKLSTVSAAAAAAAAAATASSKATALLTAAKAKPDSKSAVLANNNNSKTSSKTVAAGATN", "function": "Required for normal development of ethanol tolerance. Relies on two distinct molecular pathways: a cellular stress pathway defined by hang, and a parallel pathway requiring octopamine.", "AFDB_id": "AF-Q9VXG1-F1-model_v4" }, { "swissprot_id": "Q570B4", "sequence": "MGRSNEQDLLSTEIVNRGIEPSGPNAGSPTFSVRVRRRLPDFLQSVNLKYVKLGYHYLINHAVYLATIPVLVLVFSAEVGSLSREEIWKKLWDYDLATVIGFFGVFVLTACVYFMSRPRSVYLIDFACYKPSDEHKVTKEEFIELARKSGKFDEETLGFKKRILQASGIGDETYVPRSISSSENITTMKEGREEASTVIFGALDELFEKTRVKPKDVGVLVVNCSIFNPTPSLSAMVINHYKMRGNILSYNLGGMGCSAGIIAIDLARDMLQSNPNSYAVVVSTEMVGYNWYVGSDKSMVIPNCFFRMGCSAVMLSNRRRDFRHAKYRLEHIVRTHKAADDRSFRSVYQEEDEQGFKGLKISRDLMEVGGEALKTNITTLGPLVLPFSEQLLFFAALLRRTFSPAAKTSTTTSFSTSATAKTNGIKSSSSDLSKPYIPDYKLAFEHFCFHAASKVVLEELQKNLGLSEENMEASRMTLHRFGNTSSSGIWYELAYMEAKESVRRGDRVWQIAFGSGFKCNSVVWKAMRKVKKPTRNNPWVDCINRYPVPL", "function": "Contributes to cuticular wax and suberin biosynthesis. Prevents the postgenital fusion of epiderm cells in organs in contact, as well as ectopic pollen hydration and germination. Required during ovules formation. May regulate an epidermis-specific developmental program during gynoecial ontogeny.", "AFDB_id": "AF-Q570B4-F1-model_v4" }, { "swissprot_id": "E9JFX9", "sequence": "MKKRIVLNAFDMTCVSHQSAGTWRHPSSQAARYNDLEYWTNMAMELERGCFDCLFIADVVGVYDVYRGSAEMALRDADQVPVNDPFGAISAMAAVTEHVGFGVTAAITFEQPYLLARRLSTLDHLTKGRVAWNVVSSYLNSAALNIGMDQQLAHDERYEMADEYMEVMYKLWEGSWEDDAVKRDKKSGVFTDGSKVHPINHQGKYYKVPGFHICEPSPQRTPVIFQAGASGRGSKFAASNAEGMFILTTSVEQARQITTDIRNQAEAAGRSRDSIKIFMLLTVITGDSDEAAEAKYQEYLSYANPEGMLALYGGWTGIDFAKLDPDEPLQAMENDSLRTTLESLTHGENAKKWTVRDVIRERCIGGLGPVLVGGPQKVADELERWVDEGGVDGFNLAYAVTPGSVTDFIDYIVPELRKRGRAQDSYKPGSLRRKLIGTNDGRVESTHPAAQYRDAYVGKESVADRTQPSPFANAKAPVAE", "function": "Monooxygenase that mediates oxidation of dimethyl sulfide, the first step in dimethyl sulfide degradation pathway. Has much lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides.", "AFDB_id": "AF-E9JFX9-F1-model_v4" }, { "swissprot_id": "Q7KM13", "sequence": "MDHNMHVNAPSLHHWGYAAGPGVVMPGATATTPQSHWVPPPQSHHSAHSNHSHGHSQGHSHGIGSLKRTLSESDCDDLYSEESSKEQISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSLQSKTLDSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSCASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQLGGRTSVSRTSGSAVTESLPSHDLHSDSSSQQQQQQQQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTHDHSAVHSEQQVPTYIELTNSNRPAAIGSDSLSYSAAPQYPVSGLPGQDYNNSSVLQYATPNGAKPYRPWGAEMAY", "function": "Transcriptional repressor which acts as a downstream effector of Notch signaling.", "AFDB_id": "AF-Q7KM13-F1-model_v4" }, { "swissprot_id": "Q9HWH8", "sequence": "MDLSSLEIFRAVAHEASVTRAAQRLQRAQSNVTTRIRQLEEDLGVELFLRDGKRMSLTERGSEFLAYAEQLLALADEARQSMHPAEPGGRLRLGSMESTAASRLPALLASYHKACPRVALEVSTGTSHALFDGVRARRLDCALVAAGPGWAGELDGSGLRGEPLFREELLMILPAEHPPVHDVAEVRLRTLAGFARGCTYRQLAEDSLGTPLTVQEVGSYHAILACVAAGACVGVLPRSVLQLLGTPPLRSLPLAEVDTWLVWREGYATAAFERWRGVLGQAGD", "function": "Represses its own transcription and the expression of nmoA, a nitronate monooxygenase. The nmoA-nmoR intergenic region is the sole direct binding site of NmoR across the P.aeruginosa PAO1 genome. Other genes seem also to be under negative control of NmoR, especially PA1225 and the hemO gene.", "AFDB_id": "AF-Q9HWH8-F1-model_v4" }, { "swissprot_id": "P71052", "sequence": "MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSYHVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVLQLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAFIDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRTGVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGAGGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRDKMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVLISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQIEKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLIHLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRFIEDFHELPEADLRARLFAAINTSEEMTAASVH", "function": "Involved in biofilm formation.", "AFDB_id": "AF-P71052-F1-model_v4" }, { "swissprot_id": "O35003", "sequence": "MNLGFRVTGKFVRELLDVLDEIAEEIRQEEKEKYPYTEWERKREVVKERLRKLPEYVREAISVITVQKRVGRPKKVDLEKRVMLFLFARLMDKSNRDIEELLELFEPLFGIKVSYKTIERLYSDEEVRMALHNLFILLLREEGVSGDFSGDGTGYSLTITKHYRSNPKRKGKDFRYVFRIIDIDTGMYVGFGYSDRSEKDAFEKALGMLKSMGVKVNSISLDKYYSSRKTLRLFDAETAVYVIPKRNLARIGFDWLRVIERIVEAPYRFLKRYFKRNLSEAGFSADKRRFGWLIRQRREDRREMALFAVGLWHNVFAVRVVR", "function": "Involved in the transposition of the insertion sequence ISA1214.", "AFDB_id": "AF-O35003-F1-model_v4" }, { "swissprot_id": "Q9FMU5", "sequence": "MSLSQNAPKSKGIKREELKKQYEDVEDEEEIGSDDDLTRGKRRKTEKEKQKLEESELVEMKKLENLIFGSLYSPVTFGKEEEEDGSALFHVDRSAVRQIPDYEDDGDDDEELSDEENGQVVAIRKGEAAWEDEEEKQINVDIASVNRLRKLRKEENEGLISGSEYIARLRAHHAKLNPGTDWARPDSQIVDGESSDDDDTQDGGVDDILRTNEDLVVKSRGNKLCAGRLEYSKLVDANAADPSNGPINSVHFHQNAQLLLTAGLDRRLRFFQIDGKRNTKIQSIFLEDCPIRKAAFLPNGSQVIVSGRRKFFYSFDLEKAKFDKIGPLVGREEKSLEYFEVSQDSNTIAFVGNEGYILLVSTKTKELIGTLKMNGSVRSLAFSEDGKHLLSSGGDGQVYVWDLRTMKCLYKGVDEGSTCGTSLCSSLNGALFASGTDRGIVNIYKKSEFVGGKRKPIKTVDNLTSKIDFMKFNHDAQILAIVSTMNKNSVKLVHVPSLTVFSNWPPPNSTMHYPRCLDFSPGSGFMAMGNAAGKVLLYKLHHYQNA", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA.", "AFDB_id": "AF-Q9FMU5-F1-model_v4" }, { "swissprot_id": "A6QB63", "sequence": "MKKLALFALLMVPAILLASGHDSGEASRYLTQTGRESDFWPRVINFTIFAAILYYLIANPIKNFFKGRREGIAGQLKEIESKLQAAKDEKKEAQSHLNESVNKAAEIIEDAKKEAEILAAKIAEASENELVVLEKQFEEKITLEERKAARDVIDEVLSENITTDDIALDETKVVDIISRKAEHGKVA", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-A6QB63-F1-model_v4" }, { "swissprot_id": "Q9V3Y3", "sequence": "MFRLLVLAACLAISVHAYSDGAPKAACRDLTPQHGAKLQVTKPPYSISGPSHVRSDQKLTLTLGGDEFLGFMIQARDGQNRVVGQFQVVDSVHSQTLDCSGKDDTITHLSAQKGKPLTGITFDWIPPAGYKGNVKFMATVVQTGFVYWVGRVTKDIDVE", "function": "May have antimicrobial activity. A late response immune regulated gene that is negatively regulated by spz during the immune response.", "AFDB_id": "AF-Q9V3Y3-F1-model_v4" }, { "swissprot_id": "O32198", "sequence": "MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLLSSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPLGDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHDAVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLEGKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKASKVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGKGTQIEVKVPIFPEEKGENERDSSIID", "function": "Member of the two-component regulatory system LiaS/LiaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also involved in response to cationic antimicrobial peptides and secretion stress. Activates probably LiaR by phosphorylation.", "AFDB_id": "AF-O32198-F1-model_v4" }, { "swissprot_id": "P33212", "sequence": "MPTTPIPFTPLHMFRRLLCVGLFLFAGIHTTLGATLPLPSTSYKYTVLDQDLSAALQEFGNNLKISVNISAEVKGRIRGRIPELSPREFLDRLTDLYDLQWYYDGVVLYVSAAKEAQTRMLVLSSVHFSAFKLALDKLDISDERYPVRPAPGNGLVLVSGPPRFIALIEQTLNGLLAVAQAQPRATDTPARESVMVLFRGSSTTVVRGGRPEVFYTSEMLPENDDGGKAELSKK", "function": "Regulates cultivar-specific nodulation of soybean.", "AFDB_id": "AF-P33212-F1-model_v4" }, { "swissprot_id": "Q13442", "sequence": "MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQKEGGDGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK", "function": "Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.", "AFDB_id": "AF-Q13442-F1-model_v4" }, { "swissprot_id": "O74957", "sequence": "MSYKPSSEIALRPGYGGLGKQITLKANFFQIISLPNETINQYHVIVGDGSRVPRKQSQLIWNSKEVKQYFGSSWMNSVYDGRSMCWSKGDIADGTIKVNIGSESHPREIEFSIQKSSKINLHTLSQFVNSKYSSDPQVLSSIMFLDLLLKKKPSETLFGFMHSFFTGENGVSLGGGVEAWKGFYQSIRPNQGFMSVNVDISSSAFWRNDSLLQILMEYTDCSNVRDLTRFDLKRLSRKFRFLKVTCQHRNNVGTDLANRVYSIEGFSSKSASDSFFVRRLNGEEQKISVAEYFLENHNVRLQYPNLPCILVKNGAMLPIEFCFVVKGQRYTAKLNSDQTANMIRFAVQRPFERVQQIDDFVHQMDWDTDPYLTQYGMKIQKKMLEVPARVLETPSIRYGGDCIERPVSGRWNLRGKRFLDPPRAPIRSWAVMCFTSTRRLPMRGIENFLQTYVQTLTSLGINFVMKKPPVLYADIRGSVEELCITLYKKAEQVGNAPPDYLFFILDKNSPEPYGSIKRVCNTMLGVPSQCAISKHILQSKPQYCANLGMKINVKVGGINCSLIPKSNPLGNVPTLILGGDVYHPGVGATGVSIASIVASVDLNGCKYTAVSRSQPRHQEVIEGMKDIVVYLLQGFRAMTKQQPQRIIYFRDGTSEGQFLSVINDELSQIKEACHSLSPKYNPKILVCTTQKRHHARFFIKNKSDGDRNGNPLPGTIIEKHVTHPYQYDFYLISHPSLQGVSVPVHYTVLHDEIQMPPDQFQTLCYNLCYVYARATSAVSLVPPVYYAHLVSNLARYQDVTADDTFVETSEASMDQEVKPLLALSSKLKTKMWYM", "function": "Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H3K9 methylation necessary for centromere function. Required for recruitment of swi6 and cohesin to an ectopic dg repeat. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex. Has ribonuclease H-like cleavage (slicing) activity towards target messages complementary to siRNA and can direct site-specific cleavage of RNA substrates via siRNA. Slicing activity is required for both post-transcriptional and transcriptional gene silencing as well as for histone H3 'Lys-10' methylation spreading, conversion of double-stranded siRNA to single-stranded siRNA and siRNA-dependent association of ago1 with chromatin. A member of the argonaute siRNA chaperone (ARC) complex which is required for histone H3K9 methylation, heterochromatin assembly and siRNA generation. The ARC complex contains mostly double-stranded siRNA.", "AFDB_id": "AF-O74957-F1-model_v4" }, { "swissprot_id": "K7VCB9", "sequence": "MDVGAKEEEMGQVWWGHRAWSLLSAVRARAPLVQCITNLVSMDIAANVLLAAGASPAMVHSLREVPDFTPRCDAVYVNVGTLSEDWLPSMRAAASAGRPWVLDPVAAAASGFRMKACLELLSLCPAVVRGNASEILALASRSTAASSNFKGVDSSHCSVDAIEAAKALALSSSAVVAVSGAVDFVTDGKQVISVSNGVPMMQKITATGCAVTALIAAFVAMEPSDAIVAAACALAIFGLVGEIGMESAKGPASLRMHLIDALYCLNEETVTSRVRISLRP", "function": "Thiazole kinase involved in thiamine salvage pathway.", "AFDB_id": "AF-K7VCB9-F1-model_v4" }, { "swissprot_id": "C5A5S2", "sequence": "MLQVIFLGSGGIMPTRERNVPAIALRYKGEIILFDVGEGTIRQMNSAKLSPMRVEKIFITHFHGDHYLGLGGLIQTMNLWNREKPLHIYGPKYTFEFVQNFLNSGFFRPGFEVHVHELGETRLKFKDYEIWSFKVEHGIPALGYVFKEKDKRGKFLPEKLAQYGLRPGPILGKLEKDGKIEWNGQVIRLEDVTGPRRRGVKVVYTGDTEPCERVRLFAERADLLIHDATYLSDGDRGDSYHSTVEEACETARRAKVKLLALFHRAFRYTYDEYLSGASKICQETGVNFVIPRDFDVLTYKSGEWKRENLLEEGK", "function": "Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.", "AFDB_id": "AF-C5A5S2-F1-model_v4" }, { "swissprot_id": "Q2W8R8", "sequence": "MAEAILLETENTPCGCRSYLMAGLSYLGILCFVPLLMSRDDEYVYFHAKQGLVLWMWSVLAMFALHLPLIGKWLFGFSSMGVLVLSVAGLASVALRRTWRLPLVGYFVALI", "function": "Plays a role in regulating magnetite crystal size; partially redundant function with MmsF.", "AFDB_id": "AF-Q2W8R8-F1-model_v4" }, { "swissprot_id": "O43182", "sequence": "MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDEAGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQEKSPSGSFHFDYEVPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGGPNGIFASPRRWLQQRKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRACSTPHVQVAGKAERPTARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGPPEGVETPTDQGGQAAEREQQVTQKKLSSANSLPAGEQDSPRLGDAGWLDWQRERWQIWELLSTDNPDALPETLV", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.", "AFDB_id": "AF-O43182-F1-model_v4" }, { "swissprot_id": "Q8BM65", "sequence": "MIPSKMMSANPEEDPLDTFFQYIEDMGMKAYDGLVIQNASDIARENDRLRNETKLAYLKEKNEKRRRQEETIKRIGGEVGRGQDASYAGKHFRMGFMTMPAPQDRLPHPCSSGFTVRSQSLHSVGGTEDDSSCGSRRQPPPKPKRDPSTKLSTSSETVNSTAASKSGRSLERAEGKFTVPASHSPPRASTSGHLFPSPGSQERNIKVSAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHVPRRTSLPRDSSLSQVCSPAADPEEEEPVYIEMVGNILRDFRKEEDDQSEAVYEEMKYPIFDDLGHDSKCDFDHHSCSSQCATPTVPDLDFVKSSGPCTPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPPGACPSSLPSHGSSHAKDQTGALGPAPGASILSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSSSVPHTTPRPVSQDGAKMVNAAVNTYSAAQSGSRSRTPTSPLEELTSLFTSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDSKERGHYGSSSSREPVKAQEWDGTPGPPVVTSRMGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQASDLQQSQVPSSLANRD", "function": "Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.", "AFDB_id": "AF-Q8BM65-F1-model_v4" }, { "swissprot_id": "P0DJQ9", "sequence": "MGKTMWARAVFLCFSVGTLLWQEVLTRRIPVDTGQCGLPKSQEDLNSFLWTVRRHPPAYLFGTIHVPYTRVWDFIPQNSKKAFHDSNSVYFELDLTDPYTISALANCQMLPQGENLQDVLPRDLYRRLKRHLEYVKHMMPHWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEADIRSRGVPVLDLYLAQEADRMKKKTGAVERVEEQCHPLNRLNLSQVLFALNQTLLQHESLRAGSFQAPYTTEDLIKHYNCGDLNAVIFSHDSSQLPNFINVTLPPHEQVTAQEIDIYFRQELIYKRNERMARRVIALLKENKDKSFFFAFGAGHFLGNNTVIDVLRQNGYEVEHTPAGQTFTAAKPKTNPTSDDSMATDSPAMKYFDHVPATASYFGESDEEMLPPHLLLPDSISQLEEFGKQNSWHRKHYRNQRPRQFNDLWVRLDDSTTTLPSNTRNTNGEQSAESLVWLPEQDHHNYLDVKLSHSQSNSSPKCLSASPAFLYTLVTLCLITTMRTRS", "function": "Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave wnt8. Required for head formation.", "AFDB_id": "AF-P0DJQ9-F1-model_v4" }, { "swissprot_id": "Q94A38", "sequence": "MSSLPLRSGEKMESPSISDAVPLHAPEDATADFSQPQSPLHEVDSFPVTESSDDVVVNVSEIPNLSPSDDDFDHERNSGEDRDQDHGENPVETDGVVVPIDELNQKIIRQVEYYFSDENLPTDKFLLNAMKRNKKGFVPISTIATFHKMKKLTRDHALIVSALKESSFLVVSADEKKVKRLSPLPEIRDPKIFTVLVENLPEDHSNENIREIFGKAGSIKSVSICDPNAVEESEKGGKKENFIRTRLHAFVEYETVEAAEKAAATLNNEQDWRNGLRVKLLEQAAGKFAQRRPARREVDKEKDTTGRVHDQTGGEKNKKTREHQNHRLHHSDNPADDDGGNHQKDKNGNKGRVVGQGRRQNHQGGNGIGHGTASSSSHPNYHPVEVSKRPPGPRMPDGTRGFTMGRGKAIPPPTSTQTSHEV", "function": "Transcriptional regulator.", "AFDB_id": "AF-Q94A38-F1-model_v4" }, { "swissprot_id": "Q9LSB2", "sequence": "MASSSSSSLSFSTSKKNKTFFKKPNSAFSSSRATSLIKRQQTVFKKAKELSILCDIDVCVICYGSNGELKTWPEEREKVKAIARRYGELSETKRRKGSVDLHEFLEKMNKDDPEKEEKKKIKVRRVPKVKYPVWDPRFDNYSVEQLMGLVQSLERNLTRIQHRTCAVVEAQGQRRVQYTNMANQELMMANTMNQLQQHSNQVSMYLWNHGNGAFSQIPVSALASNQTQSLAPIPPELMIYPNSDAGNYSGSLGVQGTGINGLQNMNMLTYNNINSVNDFSKQFDQNSRAESYSSLLGVHEDGNNEFENPNMSSRNNFNVQDCAGLLGMQGAGTNGLQSMNMHDYSNNNSINSNGLSHQYVQFPTYNSQHQDRVFNLDQNGNNTRSL", "function": "Probable transcription factor that may function in the maintenance of the proper function of the central cell in pollen tube attraction.", "AFDB_id": "AF-Q9LSB2-F1-model_v4" }, { "swissprot_id": "P15728", "sequence": "MNIKGSDNGSFIKGSPENDIIDGGKKNDWIDAGNGDDRIKAGDGQDSITAGPGHDIVWAGKGSDVIHADGGDDLLYSDASYPLYVTDPHRVIPHSGEGDDVLYAGPGSDILVAGDGADVLTGGDDGDAFVFRFHDPMVGTTHCYTSVMDFDTKQDRFVLDAADFGGDRNLFDANFINHSKGFPGEFVDTFYNGAAEGAHGEHVVVITDRGFASAAAAATAIDHEARGDIIVFHDQKTLGQDGETHGATLAYVDSANHAHAFAHVDNLHDMSDLTSLTAENFGFI", "function": "The NodO protein may play a role in nodule development by direct interaction with the root hair cells or some other plant surface in a calcium-dependent manner.", "AFDB_id": "AF-P15728-F1-model_v4" }, { "swissprot_id": "Q852M4", "sequence": "MPALTRALRCALLAARVALAREKARRAFASHGEMLSQPAAALARLPPASVRVLVGFGAALLVSLVVLHRRPAARGAAGGGGPAEYDPAARFLALSEGANATIAADLRALTAGPHLAGTGAAAGAAARVLSGFRAAGLRTLTREYTPLLSYPGHASLALLRADRTLLAHLSLDEPADVGRRLVRPYHAYAPSGGAVAEAVFVNLGREEDYLTLERLGVSVRGRVAVAIRGGGYRGGVVRRAAERSAAAVLIAGHADGGVERGTVILGGPGDPLTPGWAATAGAERLDFDHEDVKRRFPAIPSMPVSGKTASAIIRTLGGPALPADWQTGVGLPVDVGGVGPGPTLVNFTYQEDRKMGMIQDIFAIIKGYEEPDRYVILGNHRDAWTYGAVDPNSGTSALLDIARRLGIMLQSGWTPRRTIILCSWDAEEFGMIGSTEWVEENLEDLQSKAVAYLNVDCAVQGIGLFAGSTPQLDNLLVDVTRQVKDPDVEGKTVHDTWNKMTGGINIERLARTDSDFAPFLHHAGIPCMDLYYGKEFPGYHTALDSYHWMEKHGDPLFLRHVAIVEIWGLLALRLADDPVLPFDYQTYASQLQEHANAFSSMMENSKWVHLLNRSIEDLSDAGLEFLKEAKKLQDQNISDGYSLMRRRLLNDRLLLAERSFLQADGLQGRGWFKHLMYSPPEDYESKLSFFPGVADAISRSSNRSAKEQQAAVRHEVRKISRAIQRAADVLRGEFSNRNESLYSSLSVAP", "function": "Involved in the regular timing (plastochron) of lateral organs formation. May regulate the rate of leaf initiation and the duration of vegetative phase. Seems to be redundant to the function of PLASTOCHRON1 and PLASTOCHRON2, but to act in an independent pathway. May be required for the synthesis of small signaling molecules that have a role in regulating meristem function. Involved in plant hormone homeostasis.", "AFDB_id": "AF-Q852M4-F1-model_v4" }, { "swissprot_id": "Q21265", "sequence": "MQNLSLSLVILSVLIAVTLACKCREQSTKESFCNAHWVSHVKVKVRVGKQGLPEGSERKGLNNLRYTVQHVEVFKKPSNMTTLPDEIFTPSEAPACGLKIAAGHEYLLAGRVEGPNALYTVLCGQVLPDDRSQTSFENVLEWKNVPQTLQSQVKSIKC", "function": "Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor.", "AFDB_id": "AF-Q21265-F1-model_v4" }, { "swissprot_id": "P87309", "sequence": "MENYTKSTTMCGKRKPTFEIYRESDFSKITNQGTVTAFDIISNKETFSESKQLKKAKSRNVTLVDKNTKADKRYKSEKLSDYLLNQEHHKNSPKIINDVLVIGKSDGLINSFPLSQNYISSSESQTSSGNVDIIGNDNSHASPYLPKFELKSQSQSNHSNVVKNQPIKLCKKTEGGTNLDHNKSINGAVKSGTSKSANKDRIYVFYEDEEVMEYRYIFGSRMQTKNHDINANNKRKIFYQNSFSNFHLLHKIIQPNYEPASAEERKLCIEILDEVLQY", "function": "Required for the formation of meiotic double-strand breaks and for the segregation of homologous centromeres during meiosis I. Interacts with the SFT and DSBC complexes, two subcomplexes involved in the formation of meiotic double-strand breaks. Stabilizes the SFT subcomplex on DSB sites and recruits the DSBC subcomplex onto DSB sites.", "AFDB_id": "AF-P87309-F1-model_v4" }, { "swissprot_id": "Q01481", "sequence": "MASHSAAGRRPTALVHIALFVAIAAVIINSSVCLGAAVHDAATSGTGALDPNVPAVPTPGGAGQPYTGRGCRTVYGCKPPAGSQP", "function": "Associated with pathogen defense.", "AFDB_id": "AF-Q01481-F1-model_v4" }, { "swissprot_id": "Q8RM04", "sequence": "MNVPVGHLRNVQVLGIDAGGTMTDTFFVDQDGDFVVGKAQSTPQNEALGLIASSEDGLANWGMSLHEALAQLQTGVYSGTAMLNRVVQRKGLKCGLIVNRGMEDFHRMGRAVQSHLGYAYEDRIHLNTHRYDPPLVPRHLTRGVVERTDMIGTQVIPLREDTARDAARDLIAADAEGIVISLLHSYKNPENERRVRDIVLEEVEKSGKKIPVFASADYYPVRKETHRTNTTILEGYAAEPSRQTLSKISNAFKERGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYKNIACSDIGGTSFDVALITQGEMTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDPYTRAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYLNPDNFLGGAVKLDRQRSVDAIKAQIADPLGLSVEDAAAGVIELLDSDLRDYLRSMISGKGYSPASFVCFSYGGAGPVHTYGYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINMPTETPDTDKEKAAATLQAAWEELTKNVLEEFKLNGYSADQVTLQPGYRMQYRGQLNDLEIESPLAQAHTAADWDQLTDAFNATYGRVYAASARSPELGYSVTGAIMRGMVPIPKPKIPKEPEEGETPPESAKIGTRKFYRKKRWVDAQLYHMESLRPGNRVMGPAVIESDATTFVVPDGFETWLDGHRLFHLREV", "function": "Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide.", "AFDB_id": "AF-Q8RM04-F1-model_v4" }, { "swissprot_id": "Q45047", "sequence": "MKILVIDIQGLIKQVFVRAFSKDNDVEILNAGFNSLNLINVFLQKFPDLVIIDENTARSNFGNSLNNVLNNISLPVVFIAQNEMLPNFGCLEQSKEKVKLIINKLNFKLTVDLFRSKYLALIKLELKNLGKNKLISSFEVKRIQAPDFSSNSKVELRENNLNDSSIRKSYRVSDVINFAPKNDPDVIIKYQGLINKHKTGKIIVVGSSTGGTEALRIFLRSFKKDSPPIIIVQHMPGGFTKSFAKNLNNEFNIDIKEAEDGDILRPGLVIIANGSYHLIVKYSSGNYFVNLLDGPLVSRHKPSVNVLFRSAAMYAGSNAIGVILTGMGDDGAVCMLEMKKNGAYTIAQDQETSVVFGMPMEAIKIGAVDKILPLSEIADHVLRRS", "function": "Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.", "AFDB_id": "AF-Q45047-F1-model_v4" }, { "swissprot_id": "Q1I490", "sequence": "MDFKDYYKILGVEASADEKAIKAAYRKLARKYHPDVSKERDAEDKFKEANEAYEVLGDKDKRAEYDEIRKYGGQHGRPFQAPPGWQSRGGNGGGGGFEGGDFSDFFSSIFGARGGNPFGGGGGRQQRSAGRRGQDVELELAVFLEETLNKESKQISFQVPQTNGAGQRTGFTTKTLNVKIPAGVTDGERIRLKGQGAPGVGGGANGDLFLTIRMAPHPLFDVEGHDLIITVPLAPWEAALGAKVAVPTLTGKINLTIRPDSQSGQRLRVKGMGLLNKQGERGDLYAQLKVVMPAQSDAAARELWTQLSEKAAFNPRTQWSK", "function": "DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM.", "AFDB_id": "AF-Q1I490-F1-model_v4" }, { "swissprot_id": "P53913", "sequence": "MSSTSDNNANSAREKKPLKFVSEGVGNVEAQRIREQVEQKKYEAEYKRKTRKSLRDQLRSNAISKQKQYNGLVRDRESFTRLSKEDLEFYQKSKNELLKKEKELNNYLDVKAINFEKKKKALLMENDSTTNTEKYLETGTSLGSKTQIKGVKTSSPKPKIKVSIKKLGRKLEN", "function": "Involved in telomere length regulation and required for survival upon exposure to K1 killer toxin. Promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase.", "AFDB_id": "AF-P53913-F1-model_v4" }, { "swissprot_id": "A0A2I8B352", "sequence": "MGAAKVLLVVLAVMVAVPNLAEGRSPPQCQYTNCAAVLCPAVYCANAYTPPCGCCDICPPQKYGGGYRPRG", "function": "Has antibacterial activity, mainly against marine Gram-positive bacteria like C.maltaromaticum (MIC=50 uM), C.mobile (MIC=50 uM), C.divergens (MIC=50 uM) and C.funditum (MIC=25 uM) but also against C.glutamicum (MIC=12.5 uM). Has very little or no activity against Gram-negative bacteria.", "AFDB_id": "AF-A0A2I8B352-F1-model_v4" }, { "swissprot_id": "Q5A1E3", "sequence": "MVKSHKRTLEKDEEHQEKKKANKISKDDMEIDAELLTQQASDSAHTDTATAAVAAVNNEQGKELEQTESSTNQTSALDKDDKETKDNLNPREETQSSHQEIDIPKDQLTNQQNLADQHQQYQYHQQLAQTNFKTEPTNSAKPPHGSEEWHRQRRENHKEVERKRRESINTGIRELARLIPTTDTNKAQILQRAVEYIKRLKENENNNIEKWTLEKLLTEQAVSELSASNEKLKHELESAYREIEQLKRGKK", "function": "Transcription factor that binds ribosomal protein gene promoters and rDNA locus with TBF1. Necessary for the expression of genes involved in assimilation of inorganic sulfate. Also required for the expression of respiratory genes and glycolytic genes. Does not bind to centromeres and is not necessary for efficient chromosome segregationas as does S.cerevisiae CBF1.", "AFDB_id": "AF-Q5A1E3-F1-model_v4" }, { "swissprot_id": "Q92340", "sequence": "MISLKIYFVLIFLFLKGINSAYVSNEEGETVDFTFSGFYANLTYPNEISELNYVEGNYLSTRIVRFNGSFYCDTTILSETNNVTGSCYVANCANDTVLEICDSGKEVHFTDMSGTTWSADTFTENLYWFCGGDGNKPNMTTAAAMNSDIDSYYVYGNWTIDTADSTVADYTCNYTHFQEAGDIEKGDVYTASADSSDSSSASSTIFKPSYFISCLLSVGLYLVLNF", "function": "High affinity heme transporter involved in the assimilation of exogenous heme during conditions of low cellular iron.", "AFDB_id": "AF-Q92340-F1-model_v4" }, { "swissprot_id": "P31077", "sequence": "MNQMWGSIEQYNTVVWHWPIAVYLFLAGLSAGAIISAIIIKWMKGNESSPWDGIIKAGALIAPLTIGAGLLLLIFDLTRPLHFWKLLIFYNFSSVMTLGVLALFAYFPVVLIFLLGVFKKELCDEGPFGFLAPLANIAYSMARPLEIVTFVLAIGVGAYTGFLLSAMYSYPLLNTPILPLLFLASGISAGISGNLLIGLLFFGKSTKGENVGYLHGLDFKVILFEAFLLFILFVGMYYQGGSTAEVAKAALTTGGLASLFWLGVAGMGLALPVVLNVALPHGIKHSSGFVMLNALIVLAGVMALRFYILYAGQTFVG", "function": "Component of the phosphorylative electron transport system with polysulfide as the terminal acceptor.", "AFDB_id": "AF-P31077-F1-model_v4" }, { "swissprot_id": "Q9CDN7", "sequence": "MGKITAIKKLKRLYRVDLSGFDDEDKIYLSEDTIVHFFLNVDKELDDADLEEIQSYDQFAQGKSLALYYISFKMRTSSEVRKYLSEHEIDNTDQIDEVINILTKNNLINDKAYAENFIEGKISMGSAGPYQIKQKLITKGIDPLIIDQALSNIYDEEKQIDVAYKLAEKTNRTYGQRLTLKQLKDKIIQNLMNKGFTYSISSIALESLELETDEENETQLLYTALEKVAKRYSKNYEGYERKQKVTQALARKGFSYDDISSALRDYTFPE", "function": "Modulates RecA activity.", "AFDB_id": "AF-Q9CDN7-F1-model_v4" }, { "swissprot_id": "Q12272", "sequence": "MRQVLQKDKRDVQLSKALSYLLRHTAVKEKLTIDSNGYTPLKELLSHNRLKTHKCTVDDIHRIVKENDKQRFHIKTLGADEEWICATQGHSIKSIQPSDEVLVPITEASQLPQELIHGTNLQSVIKIIESGAISPMSRNHVHLSPGMLHAKGVISGMRSSSNVYIFIDCHSPLFFQTLKMFRSLNNVYLSSSIPVELIQKVVVKGNLKDEEKLDTLRRILHERNIPLEKI", "function": "Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.", "AFDB_id": "AF-Q12272-F1-model_v4" }, { "swissprot_id": "Q9VX32", "sequence": "MRQFNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGDVRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEKEYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYELYVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELLDTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNKKLHQYLDKFALALEYLLPDIGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDMDEAEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVLFMGRECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDVIQEDSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSASNHKTPSGGGWKSSGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGDMEAFKAIDVYSSGLICVYSNQQSFETLKDNLERTLLCNLELEDKFENLPIVLVYQPQDLKENEVEYLRNEGMRLSEMLHCDFIDHTQNHQKYVYDILNIVILSLKLTEMKSYEPYPSNHTDLRILCCIFCGDQYDIENIVQPLVEESTLVKANEHSIIVDVFIGDAKRRVEFILSSYHGTSQYRDELIHGYIYFYSTKRRSSLANLSILAAQNANIPLQIIAVTESGGVNAFFNSDICQFLITEGNAVADRFKGSFMTFSADQYVKFAFYNPFLKTAWDNKYEVENLHVEESITLDSGEGTLENSVNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNSLNEERDISLDEIYDDNEKPKHLHQKWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQTLKVGEAPSRNCPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVAKMNFTGSGSGSGSGSGSGSTGLGLGLGSGSGCMGDSFLEPVDKDGKRYDHAQLDGEDEDSEELAEYEQIYENEDCTESDSCASSTERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGGSGPEKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEKRRIKEETARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLFCGKDAFVMV", "function": "GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability.", "AFDB_id": "AF-Q9VX32-F1-model_v4" }, { "swissprot_id": "A4QX49", "sequence": "MDDDGLLINFEVGEGPIKPQIKFTGGRWRERNRLQRSVKRGLTGSQSNDAVADDVGPAPAKRQRLSEGAAPEIQRRFRPQAQGPRSQHVSSRLFTSNPTPVTNFDEPETAPAEEPAEPALPSNAPLSDEAATFAALGLSRRIAQHLSAKLELKAPTAIQHRAVPHLVTTDEDAFLQAQTGSGKTLAYLLPIVNRILALNQNEDGTISKDASKKIHRNSGLLAIVLAPTRELCKQIATVLEKLLRCAPWIVSTTVIGGESKHSEKARIRKGINILIATPGRLKDHLDNTKVLDVSLARWLILDEGDRMMEMGFMDDLKEIVSKMREAPLKKINPDGIQLEPALPTRRVTVLCSATLDHAQVRRLGEYSLEADKTELIKVDGTEAAKEGDEASEAVFAAPSQLKQSYLVVPAKLRLVTLIALLKSSFARRGSVMKAIIFISCADSVDFHFDLLRSPIKEPKEAAAPPTPKKAPKDAGETPDTPPKETKPTKPVTNHTESTVGKACYITSAANTTITLHKLHGSLAQPVRTATLDSFSKSKDPSILITTDISSRGLDVPAVDLVIEYDPAFAVADHVHRIGRTARAGRPGKAVLFLQPGSEEGYVGLLQKNASTALTPQLYDSVLQAGFSSNIDLPPVTATNEDGQDTEQQKQLDSRKQTWTSRAEALQLHLEQRLLASDASSQASNNSGKGFNSKKGASTKLGKPAPKSSDGATGTLLASGRQAFRSHIRAYATHVRDERVYFDMTQLHLGHMAKAFGLREAPGGIGAGVQRRTVKPSAANGGGKKSTKGDDGDGLDKQDDDEAERTRRMKKMMRMVGAGASEFNIG", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.", "AFDB_id": "AF-A4QX49-F1-model_v4" }, { "swissprot_id": "A0A140NFA3", "sequence": "MQTITIAPPKRSWFSLLSWAVVLAVLVVSWQGAEMAPLTLIKDGGNMATFAADFFPPDFSQWQDYLTEMAVTLQIAVWGTALAVVLSIPFGLMSAENLVPWWVYQPVRRLMDACRAINEMVFAMLFVVAVGLGPFAGVLALFIHTTGVLSKLLSEAVEAIEPGPVEGIRATGANKLEEILYGVLPQVMPLLISYSLYRFESNVRSATVVGMVGAGGIGVTLWEAIRGFQFQQTCALMVLIIVTVSLLDFLSQRLRKHFI", "function": "Part of the binding-protein-dependent transport system for phosphonates; probably responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-A0A140NFA3-F1-model_v4" }, { "swissprot_id": "P62651", "sequence": "MRPRDQGFLVLGFTYSVLLISLATFYWLRNNDSFLHYWCVLLLCPATLWLWALIAWCDSEMFASSKDE", "function": "Probable component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. Ras may inhibit the enzyme activity of the GPI-GnT complex via the association between ERI1 and RAS2.", "AFDB_id": "AF-P62651-F1-model_v4" }, { "swissprot_id": "Q9R803", "sequence": "MEASNVALVLPAPSLLTPSSTPSPSGEGMGTESMLLLFDDIWMKLMELAKKLRDIMRSYNVEKQRLAWELQVNVLQTQMKTIDEAFRASMITAGGAMLSGVLTIGLGAVGGETGLIAGQAVGHTAGGVMGLGAGVAQRQSDQDKAIADLQQNGAQSYNKSLTEIMEKATEIMQQIIGVGSSLVTVLAEILRALTR", "function": "Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells.", "AFDB_id": "AF-Q9R803-F1-model_v4" }, { "swissprot_id": "Q59RQ0", "sequence": "MLNANKSIIRLATYSIRNRIHHLRTLHSLNYINSRINIQDTNHIRPTCPCGSKQFMLESELDSALIEFLDNDDPFSDSEIKESDDLSKGQSHVYNGSPVTKNSILQIEKQQIQKSPRPTETNKRMQIRKDPDQNDNVDDDSLSSTFEFSDMDDDFMEALKAAEEITGNNTNCIKRTASTPLKKPIAKSMKNSSTPSKSAGKKYCKYIKTSSPSPSHYLIRESGSGVDILEGSPNKVQADNASPFRITSSFSSPSQIQNQGVGANPGPKSKAEQNVSSASQSSSPPMTVSQVRNPFKVPTQFRRNYSTRPITNQGSDTKKGNSHHTILLATQKPGVPFSNPSDRSYHKLEKTEGINEAQSEAKNVKPIILSNEQEYVLKQVLSGVSLFYTGSAGTGKSVLLRSIIKSLRDKYPKGVAVTASTGLAACNIGGITLHSFAGFGLGQGKVENLIKKIKRNKKAFTRWRETRVLIIDEISMVDGHLLNKLNEIAKNLRRNNRPFGGIQLVACGDFYQLPPVVKKTAHDGTELDDVEVFFAFESSAWKETIQRTITLKEIFRQKGDQRFINMLNNLRDGNVPDDTARDFCRLSRPLKCPEGIVPSELYATRYEVDMANSRKLNTIQGDVVVYNSVDTGILPEPQKTQVLTNFLAPQVLNLKVGAQVMCIKNFDDQLVNGTLGKVIDFVDRDTYMKSESKENPSTETSDEVSGLNDYIFNDFQKPKKVVKEDAPIAEQVLFTGQLSQKVEEESESSKRKSKLKDDLMKDYKNKKYPLVKFLLPDGITFRTVVVEPEQWTTEDEDGTVLVSRIQFPLILAWSLSIHKSQGQTLSKVVVDMKKIFENGQAYVALSRAVSRAGLQVLNFNRSKVASHRKVIEFYKNLSSHEKESRSGQQRLNFMQTSVKSVARAQI", "function": "DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replication fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.", "AFDB_id": "AF-Q59RQ0-F1-model_v4" }, { "swissprot_id": "Q7UN36", "sequence": "MLVVAAMRVWNPEEGWANRVGRKREGKIVEILRRVTMTAHGLSHFPRQLLRMPRAALRKPNPALDLDSWLKTPEDLPATINSQTLFGNDQPLEIEVGSGKGLFIQTESDRRPEHNYFGIEIARKYAAHAAARLAKRERANAKMLAGDATPLFAVTDEGKRIEDGSLDGVHVYFPDPWWKKRHRKRRVLSHDNILNFSRCLRVGGRLHFWTDVLDYFELTVELIAEIAPELGVPLPETQRESTHDLDFHTHFERRSRKMGIPVYRVCYRKRS", "function": "Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.", "AFDB_id": "AF-Q7UN36-F1-model_v4" }, { "swissprot_id": "Q8NKQ2", "sequence": "MKNVDDLIASAAELADRGLSKGEIADELNVSRETASWLVERSGAATEPEPRAEPEGPDDIHVDWNAIGSGGKRLTYVGRALADLLMETNGEADVTVGIEKAGVPLATSVSRELETTLGAYSPAKHQWDEGDLEDLGGGFSRNFSPVEGRDCFIVDDTVTSGTTLRETIDAIRSEGGEPLACVVIVDKQGVEEIDGVPVHSLINVVRVGEQ", "function": "May have some orotate phosphoribosyltransferase activity, but not enough to ensure growth in the absence of the physiological OPRT.", "AFDB_id": "AF-Q8NKQ2-F1-model_v4" }, { "swissprot_id": "C8V212", "sequence": "MVQSPMISCPLKQTNEIDWIQPLKDYIRQSYGEDPERYSQECATLNRLRQDMRGAGKDSATGRDLLYRYYGQLELLDLRFPVDENHIKISFTWYDAFTHKPTSQYSLAFEKASIIFNISAVLSCHAANQNRADDIGLKTAYHNFQASAGMFTYINENFLHAPSTDLNRETVKTLINITLAQGQEVFLEKQIMDHKKAGFLAKLASQASYLYAQAIEGTQEHAKGIFDKSWVTLLQVKSAHMGSVASYYQALADGESGSHGVAVARLQLAEKHSTSALSWAKSLPSSISPNTNLTSEAGPSLVDIVKFHLANVQSQLATFVKDNDFIYHQPVPSEAGLSAVSKLPAAKAIPVSELYQGQDIQRIIGPDIFQKLVPMSVTETASLYDEEKAKLIRAETEKVETADGEMAASLDYFKLPGSLNILKGGMDQEVMVDEEFQRWCQELAGHDSFAKAFDTLQDRKSEVLATLDQCAKQLDLEESVCEKMRSKYGADWSQQPSSRLNMTLRNDIRTYRDTVHEASASDAQLSATLRQYESDFDEMRSAGETDEADVLFQRAMIKAGSKQGKTKNGVTSPYSATEGSLLDDVYDDGVPSVAEQIARVESILKKLNLVKRERTQVLKDLKEKVRNDDISNVLILNKKSITGQESQLFEAELEKFHPHQMRIVQANHKQTALMKELTKTYGDLLQDKRVRAEQSKYESITRQRNSVMARYKKIYDSFNNLGSGIKQAQTFYAEMTETVDSLKKNVDTFINNRRSEGAQLLGQIEREKAAGTSDHEEREREKLRQLMERLSTEPKPPSVPPGSSTAGPAKAKSPPPPVKAPAYPTNIAPPKASPHFAPTVPQQHGTPVSHSPAPYSQYVPPGAGVSYLPSQSFQQGAAAPLSEGYNPMAYPIPASSMSPPPSQPFYSPTPTPFYTSPTPPVPSGQYMPQGYVPPPPPPRPQQPTYPPSTGPFPSGPGGYAQSRPYGSSQHHKAHSQSSPQTGPSVSANSSDPWAGLNAWK", "function": "Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.", "AFDB_id": "AF-C8V212-F1-model_v4" }, { "swissprot_id": "Q99K82", "sequence": "MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHGNPIYQLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDVVEEFSDLYNEVYNMTQEFFRHGKPVNAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQYLKVESCESSSHSIDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPPHVIQLGKPVRCIHWDQASAHPRGPEIEPRGEGDHNHDTGEGGQSGENPQQGRWDEDEPWPVVVECEDCEVIPADHVIVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGP", "function": "Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.", "AFDB_id": "AF-Q99K82-F1-model_v4" }, { "swissprot_id": "O43261", "sequence": "MRPCIWIHVHLKPPCRLVELLPFSSALQGLSHLSLGTTLPVILPERNEEQNLQELSHNADKYQMGDCCKEEIDDSIFY", "function": "May act as a tumor suppressor.", "AFDB_id": "AF-O43261-F1-model_v4" }, { "swissprot_id": "A6NFI3", "sequence": "MAALHTTPDSPAAQLERAEDGSECDPDQEEEEEEEEKGEEVQEVEEEEEEIVVEEEEEGVAEVVQDAQVEAVAEVEVEADVEEEDVKEVLAEEECPALGTQERLSRGGDAKSPVLQEKGLQASRAPATPRDEDLEEEEEEEEDEDEDDLLTAGCQELVTFEDVAVYFSLEEWERLEADQRGLYQEVMQENYGILVSLGYPIPKPDLIFRLEQGEEPWVPDSPRPEEGDIVTGVYTGAWFWTDDIEDHEEEDDEDFLAEVAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSAQTPEGWGPDPGGLGVLADGSEAKPFLPGREPGANLLSPWAFPAAVAPPAGRPETTCDVCGKVFPHRSRLAKHQRYHAAVKPFGCEECGKGFVYRSHLAIHQRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCAFCGAGFGRRSYLVTHQRTHTGERPYPCSHCGRSFSQSSALARHQAVHTADRPHCCPDCGQAFRLRADFQRHRRGGGCAEAGGDGPRREPGETAAAAGPEDTDPGPEGSEVGEADGEAEAAAEEREEAAVAAPTPSGKVDPAPERRFLELGNGLGEGEGPSSHPLGFHFPVHPKSWLHPDSFPILGLPDFRERLPVDGRPLPAPLGGPLSLVEGTGLACDPFGGGGAAGGGGGLRAFGPAIGGLLAEPAPAALAEEESPWICSDCGKTFGRRAALAKHQRYHAGERPHRCADCGKSFVYGSHLARHRRTHTGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTAHGRAHTGERPYACGECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRTHTGEKPFRCADCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERPYACANCGRRFSQSSHLLTHMKTHRGATAAPGSGSAPAPAPKPEAAAKGPSSAGPGERGSALLEFAGGTSFGSEHQAAFAGPSGAYREGVL", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-A6NFI3-F1-model_v4" }, { "swissprot_id": "Q6P2H3", "sequence": "MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAIGTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFDIPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGPHSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ", "function": "Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity.", "AFDB_id": "AF-Q6P2H3-F1-model_v4" }, { "swissprot_id": "Q4L7L1", "sequence": "MRKCARIIYNPTSGKELFKRTLPDVLIKLERAGYETSAYATEREGDATLEAERALKRDYDIIIAAGGDGTLNEVVNGIAEQPNRPKLGIIPMGTVNDFGRALHLPSDIMGAVDVIIDDHTTKVDIGKMNNRYFINLAAGGQLTQVSYETPSRLKSIVGPFAYYIKGFEMLPQMKAVDLRIEYDNQVFQGEALLFLLGLTNSMAGFEKLVPDAKLDDGHFTLIIVEKANLAELGHIMTLASRGEHIKHPKVIYEKAKSINISSFTEMQLNVDGEYGGKLPANFLNLKRHIEVCTPKDIYNEELTEDQQVEDGIIEEKPSNEEIIKNNEISE", "function": "Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway.", "AFDB_id": "AF-Q4L7L1-F1-model_v4" }, { "swissprot_id": "Q93841", "sequence": "MTFLAILFVIAVLLLLAQLPVIGFYIRAVYFGMCLIIGGFLGGLASIPFGKSPNNHFRMFKIFQAMTWPMGVRFELRNSEILHDKKPYIIIANHQSALDVLGMSFAWPVDCVVMLKSSLKYLPGFNLCAYLCDSVYINRFSKEKALKTVDTTLHEIVTKKRKVWIYPEGTRNAEPELLPFKKGAFILAKQAKIPIVPCVFSSHKFFYSHAEKRLTSGNCIIDILPEVDSSKFDSIDDLSAHCRKIMQAHREKLDAEAANLNI", "function": "Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.", "AFDB_id": "AF-Q93841-F1-model_v4" }, { "swissprot_id": "O42611", "sequence": "MKLLKPSWVSHNGKPIFSVDIHPDGTKFATGGQGEDSGKVMIWNMAPVLKEEDEKNENVPKMLCQMDNHLACVNCVRWSNNGLYLASGGDDKLVMVWKRAALIGPSTVFGSSNKLANVEQWRCVTILRNHTGDVMDVSWSPHDVWLASCSVDNTIVIWNARKFPEMVTCLRGHTGLVKGLTWDPVGKYIASQADDHSLRVWRTVDWQMEANITKPFSECGGTTHVLRLSWSPDGQYLVSAHAMNNSGPTAQIVERDGWRTNMDFVGHRKAVTVVKFNPKIFKKKQKNGGSPKPSCPYCCCAVGSKDRSLSVWLTSLKRPLVVIHDLFDKSIMDISWTLTGLGMLVCSMDGTVAYLDFSLDELGDPLSEEEKNSIHQNIYGKSLAITNTEPQLSTTIIENPEMLKYQQERRNSTQANSGPGATGSESATPKLNSVMNGESLEDIRKNLLKKQVETRTPDGRRRITPLCIAQLDTGDFSPALFNSAPILPSGSSMSNQLTSQLSSDSSPGQAPPLGLRPSQDPMLISPPPSSAAKVLEDNKDGVKSCLLLTSASKIEPMKALDSRFTERSKATPGATAAIASSTGLTPSERPKESTPMQKDVKSKEDTSSDSEDKMATINKNLAFNKRKPELLMDGAEVVEKRKKGRPRKDKMAASIAQPLTQTTSPAEREPSRAAAAGAGAAAPTAAAALKLPTPSIKKAFTLQVSMDPSVVLEVENEVSVVAGSRLSQLRCSRDGRDWNTLLPSSVLTAAGSSDVVAVASQDRMLSVFSSCGRRLLPAIQLATPASALHCSAHFVMVLTSGATLSVWDVHKQKALVKNESLLTILSGAAVTVSQSMLTQQGVPVVGLSNGKSYCFSLSLETWTLIADTADSLVQCADFRNCLPNQDAPMSSGPLAAMQGRNFNAGRLASRLSSTPHHLQQSMTLAFLENQLASALTLQSAQEYRYWLLIYARFLVNEGSEYRLRELCKELLGPVHKSATTSWEPTTLGLRKRDLLREVLPVVGENLRFQRLFTEYQDQLELLRNK", "function": "Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.", "AFDB_id": "AF-O42611-F1-model_v4" }, { "swissprot_id": "Q06200", "sequence": "MVMSRIRDTIARPFQNLTALEKVVQWLRLGTTLLIISFGLALTVGPLSSPRTLYMSRLDTYSADITTGLFTVLRESMEQSTSTEENNGVGLTTSELYILTAYTESQIKNVPQYITVSLYGRCDSTYTMVEVFDSEGNMHSVKNSTTKSTCSSIGTDYLFDYREVLESLGLDIILDYAYNKIGSQQAESSAYTTYMRSLKHKKANVLHLLYAVISFQVCMLFFMIWYYYIKGRFMNALKERALVHINSLLSLVVFIGGLISSISLAWVNYTIQSRINTELEAFGFSYHLGVTWFALLWCFAGLISVSCLAWSGLEWCISDNGTSYGGGIDDKFLGYQAGVFTDADLDDETSYSQRYPQRQSTSGEAELMRNSDTMATIRKTSDVDLNSENDANTSLDHGNPTANISNGGKHEPFATREEFELQDIRFRSSNDSEESMQRVIKPSSALQF", "function": "May be involved in cell wall organization and biogenesis.", "AFDB_id": "AF-Q06200-F1-model_v4" }, { "swissprot_id": "Q94887", "sequence": "MRPPRSNTKAAFSSLQFGLLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLTERGPDKARLNGNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDSTELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLNVSFYFRTYEETGVMLHHDFYSGGYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFVISIEKNRLILNIDQRPMTTTKSMQVATGAQYYIAGGKDKNGFVGCMRLISVDGNYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYDANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFRPFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIAENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNFDIKASADAQFNNIQYMYIGKNESMTDGFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCGVEPVTHPPIEIETRPPPLVDEEKLRKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGDYLTHEDQGADGADDPDDAVLHSTTGHQVRKRTEIFI", "function": "Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.", "AFDB_id": "AF-Q94887-F1-model_v4" }, { "swissprot_id": "Q7UQD2", "sequence": "MRRPMIASLLLDTLPLAQMPKVTTALLIGALVIFAGIVVVLFIFTSYFGLWIQSVLTGSKISFGNLIGMTFRKVNTRAIVRSKIMATQAGLDDPELTVGALEAHYLAGGNVQQVIRALIAAKKAKTISLTFREATAIDLAGRDVLESVQTSVYPKVIDCPPRGSAKPSLDAVAKDGIQLKVRARVTVRANLQQLIGGATEETIIARVGEGIVSAIGSADDHKAVLENPDVISKAVLVKKLDSQTAFEIVSIDIADIDVGANIGARLQADQAEADTAVARANAEGRRAAAVAEEQEMQAEIAKSQAQVVEAQSDVPRAMAEAFRSGKLLVMDYYRLQNVSADTEMRRALAGHSHDPDTPEETH", "function": "Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.", "AFDB_id": "AF-Q7UQD2-F1-model_v4" }, { "swissprot_id": "Q8P9V9", "sequence": "MTDAVLELPAATFDLPLSLSGGTQTTLRAHAGHWLVIYFYPKDSTPGCTTEGLDFNALLPEFDKAGAKILGVSRDSVKSHDNFCAKQGFAFPLVSDGDEALCRAFDVIKEKNMYGKQVLGIERSTFLLSPEGQVVQAWRKVKVAGHADAVLAALKAHAKQ", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.", "AFDB_id": "AF-Q8P9V9-F1-model_v4" }, { "swissprot_id": "Q10336", "sequence": "MEYQEEASLASAEDSTFIASSPVQSVSEMKSIKQKSFQYFDDYEKNVSDKTIQFQKLQMTAKEIIDAFERDSTQRTLQIESLESKIGEQERDLNNEKLASETLREKTQLLEKENGALKVENGYLYEKSRKLEEEMAHLKKKCNVYKSKFEESSLRCKSLYSSNTKLKDSMETMKRRMETETKEMNKIKPKNDSESDRFKRNSQSLSQQSPLLDVHSPDNSNHRTMLNINNSSPIKPKKIFKPNEVKNRISRLQKTFADLENQHHSFQQICQTLRKRLENDSSTTKQRLSKLEEIIRNRAPPSYSFSLNCSHTYQPVSCVEPVNHDLS", "function": "Has a role in meiotic nuclear oscillation and recombination. Required to remodel astral microtubules into the 'horsetail' astral array maintaining the 'horsetail' nuclear movement. Promotes homologous paring of chromosomes during this movement.", "AFDB_id": "AF-Q10336-F1-model_v4" }, { "swissprot_id": "Q98RK6", "sequence": "MKLFLEKSRFLRFLENTTKIIESNNSNYELRGAYFQVRQDKIILISSNEDISIKNEYLLDGIKNKTEGESDFLVLNSLLKNIIKKCSDSIILEKEKNTLKIFSDLQSYEINLLDHERFPDIKFGLNNSQLQLKTEQFKQALKNVVFAADLSNAQELLLNSVNLSLKNNILTLVATNRARIAMQKIKTEDSQEFNLTINSKVVKELISLSMSNTLILSPGTFELKIKSGNLEIKTKVIEIPYMNVENVFPNKFNFVIHIDKKELLSLIDKVSIVNDEKNGNKILIEYNPSKKEKKLKLSSYWPDLGFSEVFSDNFEVESEILLKFFINANYLKESINVFDGMISIFITENKDRMVISSETNLNNKQLIAALRGH", "function": "Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.", "AFDB_id": "AF-Q98RK6-F1-model_v4" }, { "swissprot_id": "Q1MLH5", "sequence": "MSPRSGLLIVLGFTLWRVVMLNFDATDFFVDEAQYWFWSQNLDLGYYSKPPMIAWVIRAMTELSGSNAIYWIRLLGPLIHMAAALVLMKTAKRFVGPEIEGWTGATYITLPGVALSSVFFSTDVILLFFIAIALLAYFGLTQRRSVGLALVMGLGVGLAFLTKYAVLFVVPGGAIALLLIPAARIAVRDVIIAVAVAAVVALPNLWWNLQHDNTTVRHTQDIAHWSELGINLRRGLEFFAAQFGVVGPIIFFAMLWAVYRMIRGRSDDREKMLVWLSMPVVLLITLQATVAKAYANWAVTAYVAGTILAVWLLYLKWPKGLRLSLTINGIASLLFPLATIFPHQLLLPNGDALMKRYLGRAEVSREAAALATQAGTDIIVTDNRDMVADLFYTLRDASYRIYARAPAGLPESYYEQEFALPADITGKVLFLTDGAFTCATETPEVLKNWQPTEGNYKGKTLSIYKVSATCLAP", "function": "Involved in the modification of the lipopolysaccharide (LPS) lipid A moiety. Catalyzes the transfer of a galacturonic acid (GalA) residue to the 4'-position of 4'-dephosphorylated lipid A, using dodecaprenyl phosphate-GalA as the donor substrate. Acts before the other GalA transferases RgtA, RgtB and RgtC.", "AFDB_id": "AF-Q1MLH5-F1-model_v4" }, { "swissprot_id": "Q12008", "sequence": "MTASTPSNVMTLFLLRHGQSELNHENIFCGWIDAKLTEKGKEQARHSAELIEQYCKANNLRLPQIGYTSRLIRTQQTIETMCEEFKLKPQLQVVYDFNKIKLGDEFGSDDKDNMKIPILQTWRLNERHYGSWQGQRKPNVLKEYGKDKYMFIRRDYEGKPPPVDLDREMIQQENEKGSSTGYEFKEPNRQIKYELECSNHDIVLPDSESLREVVYRLNPFLQNVILKLANQYDESSCLIVGHGSSVRSLLKILEGISDDDIKNVDIPNGIPLVVELDKNNGLKFIRKFYLDPESAKINAEKVRNEGFIKNP", "function": "Could be non-functional.", "AFDB_id": "AF-Q12008-F1-model_v4" }, { "swissprot_id": "Q59V02", "sequence": "MKYSTLAWLVIASYTVFAQDGTSVTGYTTTIVIPGSPPAGAGTAHGDTENTGTVHTTEHLTGTEETHTTGATPETTTIVAPTTTHENTTTHETSVENTATVHHNTTTLHHNTTTIHPNATGTETHTETGTGTLTGTGTEGPALTTTTVAEAFSLAAGASLGYLVALLFL", "function": "Putative adhesin which may be involved in cell adhesion and virulence.", "AFDB_id": "AF-Q59V02-F1-model_v4" }, { "swissprot_id": "Q55ER5", "sequence": "MIKNSNINSNSRLDDPILQEIELNKVEIGKHASWSVSSAKPGSGVEQLRDNNLDTFWQSDAQQPHHITIQFPKKCYIENLLIHCDYKLDESYTPCKISIKAGTILHDLQEIILTELEEPSGWINIPLSFNNNSLKANLLQISILSNLKNGRDSHIRQIKVYGKKISIENYTQYPKFNSPEVSMFQTLR", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.", "AFDB_id": "AF-Q55ER5-F1-model_v4" }, { "swissprot_id": "C5DE74", "sequence": "MTGLEGAQNLTVADKQLTPDEGVLTESPKMTNIHEIVEDTAASSENGDSEAKEIAAKIRAGTLENVEFTEYANYLGTPGNDQILREFLLLLDPLPSSITGTLRKLSSSLYFIAEAANLDTILEALSRQWLSEHNKAHYQDNYKLCHIVMFALLMLNSTLHNSEADLSFTIEEFRENTINALQKESPDIDVPSFNRELSLCYYQLDNEQLPLLRPPSQPRYSLSGRRTNGNGGHSNMKKASMLSLERFQTNQSLISTQNSMATLTSRDTTANSNYRMRNNKPLQKLYLDEPFDAELQDLNGTPWLMDSMVNVQEASKANNSTSQLLSSPVTRKRKLMSWFRKHTKDTIFNENIHAADTDNWQHARIRIYQGRLFVYKFKGFGRERSIPRDIHKWSLEMCKRSCSQFHVYNLYGTIASLVQENIVASENSNVSSASFLIDFPHGLDSTSGLSFRFKTRNQDEAKQFTACCNFWSARISPIPSAQVEMISNEEYGWSPRLLEGESGAEQVNLAQVKLAHWKPLVGLDAIFSELDEGIALWDFDSQLGNLRVFTELLGAQLDEHNAVKPKMVELWAKKGREYQPQFEAAMENWNNKYLYLNKQYQKHLVYLKALENAVQFYERSKSVKNPETKNAAKEQS", "function": "Guanine nucleotide exchange factor for ARF3 required for localization of ARF3 to the bud neck and tip and involved in actin patch polarization.", "AFDB_id": "AF-C5DE74-F1-model_v4" }, { "swissprot_id": "Q6NRD5", "sequence": "MLINKVKDLETGKIIPGAQLLFGYNILNVALQKDVEEVPAKHLDKLTIEDREQTSTEQRHADECNQDAERTHRDIDKSQDLRTRTLKVIKHSVDEEEVGYTIIDQFQPIFGPAIRHLQNQKVISIGAVGQNICRHGKLSWLQFATRSRVYLFDVLVLGSKVFKNGLQMVLEDKGILKVIHDCRWLGDILSHQYGIILNNVFDTQVGDVYLFSMETGGFLPHGTRTLEECLIHHLSMLPSKVSFLAHRQTLTKEYHDIWFDRPMDPTLLKLLSLEVTYLMPLRSAMLDAMFSDFTLLVDGYLNAYRRGTADILESPELSVAELPKELQQLRVLQQMRREKALKEYDVNNKGLLTRVEAEKAPRSEASGTKHDAELENVVKLTKSEKSFHQTMTTNAPLLENQTEKQQGALCQKFPVVPNCFPRGPFDYYLYKKWASNDTPTTNVS", "function": "RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the piwil2 slicing-triggered loading of piwil4 piRNAs. In the PET complex, exd1 probably acts as an RNA adapter. Exd1 is an inactive exonuclease.", "AFDB_id": "AF-Q6NRD5-F1-model_v4" }, { "swissprot_id": "Q04781", "sequence": "MSFGGINTFQQYNTDLGLGHNGVRISLNYFDGLPDPSLLNSLYSNELKLIFKSLLKRDETTKEKALMDLSNLISDFNQNEYFFNDIFLLCWSQIYAKLIISDYKVIRLQSHQITIMLVKSLRKKISKFLKDFIPLILLGTCELDYSVSKPSLNELTECFNKDPAKINALWAVFQEQLLNLVKEIVVNENEDTISDERYSSKEESEFRYHRVIASAVLLLIKLFVHNKDVSERNSSSLKVILSDESIWKLLNLKNGQNTNAYETVLRLIDVLYTRGYMPSHKNIMKLAVKKLLKSLTHITSKNILKVCPVLPSILNLLATLDDYEDGTIWSYDKSSKEKVLKFLSVSRTSPSPGFFNAVFALYSSTKRHSFLDYYLEWLPFWQKSVQRLNEKGFSARNSAEVLNEFWTNFLKFAEDSSEERVKKMVESEIFNSLSCGKSLSEYTKLNQTLSGVFPPDKWEREIEDYFTSDEDIRKIKVSFEKNLFALLVTSPNNESAISRLFDFFVQLIETDPSNVFNKYDGVYDALNYFLDSDMIFLNGKIGKFINEIPTLVQESTYQNFAGIMAQYSNSKFFKMNTDAITSLEDFFIVALSFNLPKTIILATMNELDNDIYQQLMKSDSLELELYIEDFMKNYKFDDSGEIFKGNNKFLNQRTITTLYRSAVANGQVEQFCAVLSKLDETFFSTLLLNTDFLSCALYEVSEDTNEKLFKLSLQLAKGNSEIANKLAQVILQHAQVYFSPGAKEKYVTHAVELINGCNDTSQIFFPANAIEVFARYMPAIDYRSSLVSSLSTNTHLLLTDDKPINLKNMQKLIRYALFLDALLDALPERVNNHIVAFITVVSELVTDYNCLSEEPNDLYYDFGHTFFKHGKVNLNFSDIVGNVIQPANGGDAMLTFDIAESNSVYFFYYSRVLYKVLLNSIDTVSSTTLNGLLASVESFVTKTVRDQKSTDKDYLLCAILLLMFNRSNSKDEITKLRTLLASQLIGIREVELVDQEFKSLALLNNLLDIPQADKQFVPIAPQRLNMIFRSILKWLDSDLAYEPSFSTVRLLLLDFFTKLMRFEGVRDMGITAFELSERLLADSLSMCQIDDTLYLLELRSSCLNLYETLSQGVSKNGEEISEYGDEIQENLIELMFLNFNQERNNQVSTLFYQKLYKVISSMELKKLESQYKRIFEVVLNDKDIGSNINQSRLLTTLLGSLVVKTQQDIIIEYELRIQKQTGSDVDGSASDNDVNSKFKLPQKLLQKVTDEVPKEYLEYENKNSFIKYLWYWHLILMYFKDTSYNMRQIFIEQLKEAGLINRMFDFITDQIDLRDTEFWKQVDTKEISEYNIVGNNFSPYKEDIFEECKKLLGHTLYQLFNNVGCLTSIWWLNIKDRTLQNDIEKFVSEFISPILIKNEFDDINSKMDRLTSNDDALTIKLNNITNEVKASYLIDDQKLEISFKLPKNYPLTNIQVNGVSRVGISEQKWKQWIMSTQHVITGMNGSVLDSLELFTKNVHLQFSGFEECAICYSILHAVDRKLPSKTCPTCKNKFHGACLYKWFRSSGNNTCPLCRSEIPFRR", "function": "E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.", "AFDB_id": "AF-Q04781-F1-model_v4" }, { "swissprot_id": "H9IUR0", "sequence": "MDNLYTKGELLQVHTKNYDVFEGRFYSMAQDKTKISLYDVKEIPHGDANDGVLHYYDSEIREVVKLQESTEKKVLKISQTKYEEILKISKKYIFINQVDKSFHEAVDDLNQQDFIAVSGDGANMGRKCKMPFLVLSTDHQIYIFDIQVMQYHAFESGLKKILEGDSPKKIAHDCRKLSDCLYHKHNVKLKSVFDTQVGDLIITKNKKVTLPNKVKSLGECLTNYLGLQQNTIDEKLDIVQSTERPLSVKIKDSLARNIAFLHHLSEVINEEMQLPFYRGVECYIENIRSSDDFKAWELCGKLNQIPKEFRNAIDY", "function": "RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.", "AFDB_id": "AF-H9IUR0-F1-model_v4" }, { "swissprot_id": "P0AE13", "sequence": "MNNKGSGLTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVIDGSELTLDRSMSAGLTRYFPTTELAQIGDETADGIYHPTEFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKLPGQANRFYEGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR", "function": "Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.", "AFDB_id": "AF-P0AE13-F1-model_v4" }, { "swissprot_id": "Q89B27", "sequence": "MIKVETKTLPAISLGNLDSYIREANSWPMLSSQEEKYLSEKLFYHGDLNAAKTLILSHLRFVIHVSRNYSGYGLLQADLIQEGNIGLMKAVRRFNPKIGVRLVSFAVHWIKSEIHEYVLRNWRIVKVATTKSQRKLFFNLRKTKQRLGWFNDHELELVAQELGVKREDVREMESRMSAQDIALHHVPDNFREEQNFSYTIPYLKDSLSDFANHVEEDNWEAHKTNKLSNALSSLDERSRNIIHARWLDDSDHKMTLREIAHNYGISAERVRQLEKNAMKKLKVAIET", "function": "Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.", "AFDB_id": "AF-Q89B27-F1-model_v4" }, { "swissprot_id": "Q29075", "sequence": "PGLAFSGLTPEHSALARAHPCDGEQFCQNLAPEDPQGDQLLQREELGLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKEKTGLI", "function": "May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans.", "AFDB_id": "AF-Q29075-F1-model_v4" }, { "swissprot_id": "A9CES3", "sequence": "MHAIQFVEKGRAVLAELPVADLPPGHALVRVKASGLCHTDIDVLHARYGDGAFPVIPGHEYAGEVAAVASDVTVFKAGDRVVVDPNLPCGTCASCRKGLTNLCSTLKAYGVSHNGGFAEFSVVRADHLHGIGSMPYHVAALAEPLACVVNGMQSAGIGESGVVPENALVFGAGPIGLLLALSLKSRGIATVTMADINESRLAFAQDLGLQTAVSGSEALSRQRKEFDFVADATGIAPVAEAMIPLVADGGTALFFGVCAPDARISVAPFEIFRRQLKLVGSHSLNRNIPQALAILETDGEVMARLVSHRLPLSEMLPFFTKKPSDPATMKVQFAAE", "function": "Involved in D-altritol catabolism. Catalyzes the oxidation of D-altritol to D-tagatose.", "AFDB_id": "AF-A9CES3-F1-model_v4" }, { "swissprot_id": "Q5L9Q6", "sequence": "MKKVRAAIVGYGNIGRYVLEALQAAPDFEIAGVVRRAGAENKPAELNDYAVVKDIKELQGVDVAILCTPTRSVEKYAKEILAMGINTVDSFDIHTGIVDLRRELGACAKEHGAVSIISAGWDPGSDSIVRTMLEAIAPKGITYTNFGPGMSMGHTVAVKAIDGVKAALSMTIPTGTGIHRRMVYIELKDGYKFEEVAAAIKSDAYFVNDETHVKQVPSVDALLDMGHGVNLTRKGVSGKTQNQLFEFNMRINNPALTAQVLVCVARASMKQQPGCYTMVEVPVIDLLPGDREEWIGHLV", "function": "Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate (m-DAP), since the activity with L,L-2,6-diaminopimelate is less than 5% of the activity observed with m-DAP. Can use NAD(+) only very poorly since the activity observed in the presence of NAD(+) is about 14% of that with NADP(+).", "AFDB_id": "AF-Q5L9Q6-F1-model_v4" }, { "swissprot_id": "A0A179H324", "sequence": "MAPTDRNPVQVQYYAKGKKTTESSGPAPAPLILIHDGGGTTFAYFTIGRLERDVWAIHSPTFTSAQPWEGGMDGMAKHYIELIEKVAGIKGKILLGGWSLGGYVALTMAHMIASSPASFEISIDGILMMDSPWLVAGRDLPIGTPQPALIGIPDLVRKSLDNCERMLYHWELPQWGRSSGKAFKFSAGNEKFETQPGTVLYRSLKGDWRAVERTVSHELTEQQALQTPPSGPPPAVMLRSVIPAPTKGSSGKPCRVDQFRDELLLGWDGKYNTDMIHAVLEARSHHYDMFNQLYVDEVTETIKEAIQIIETVLPNE", "function": "Probable thioesterase; part of the gene cluster that mediates the biosynthesis of the lipopeptide antibiotics leucinostatins that show extensive biological activities, including antimalarial, antiviral, antibacterial, antifungal, and antitumor activities, as well as phytotoxic. Leucinostatin A contains nine amino acid residues, including the unusual amino acid 4-methyl-L-proline (MePro), 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHyMeOA), 3-hydroxyleucine (HyLeu), alpha-aminoisobutyric acid (AIB), beta-Ala, a 4-methylhex-2-enoic acid at the N-terminus as well as a N1,N1-dimethylpropane-1,2-diamine (DPD) at the C-terminus (Probable). The biosynthesis of leucinostatins is probably initiated with the assembly of 4-methylhex-2-enoic acid by a reducing PKS. Two reducing polyketide synthases, lcsB and lcsC, have been identified in the cluster and it is not clear which is the one that assembles 4-methylhex-2-enoic acid since both contain KS, AT, DH, cMT, ER, KR and ACP domains (Probable). The polyketide residue might be transferred to the NRPS lcsA, mediated by two additional enzymes, the acyl-CoA ligase lcsD and the thioesterase lcsE. The linear polyketide carboxylic acid, which is released from PKS, is converted to a CoA thioester by lcsD, and then lcsE hydrolyzes the thiol bond and shuttles the polyketide intermediate to lcsA (Probable). The C domain of the first module catalyzed the condensation of 4-methylhex-2-enoic acid and MePro carried by domain A1, followed by successive condensations of nine amino acids to trigger the elongation of the linear peptide. A5 and A6 domains of lcsA are proposed to incorporate leucine, A2 AHyMeOA, and A3 incorporates HyLeu. A4, A7 and A8 incorporate AIB (Probable). The AHyMeOA in leucinostatin A activated by the A2 might be produced by the second PKS (lcsB or lcsC) present within the cluster (Probable). The MePro is probably produced via leucine cyclization and may originate from a separate pathway, independent of the cluster. Another nonproteinogenic amino acid, beta-Ala, could be produced by an aspartic acid decarboxylase also localized outside of the cluster. Two candidates are VFPBJ_01400 and VFPBJ_10476 (Probable). The final peptide scaffold may be released by the NAD(P)H-dependent thioester reductase (TE) at the C-terminal region of lcsA (Probable). Transamination of the lcsA product by the transaminase lcsP may produce DPD at the C-terminus (Probable). Further hydroxylation steps performed alternatively by the cytochrome P450 monooxygenases lcsI, lcsK and lcsN then yield the non-methylated leucinostatins precursor. It is also possible that leucines can be hydroxylated prior to their incorporation into the peptide (Probable). Varying extents of methylation then lead to the formation of leucinostatins A and B (Probable).", "AFDB_id": "AF-A0A179H324-F1-model_v4" }, { "swissprot_id": "P16621", "sequence": "MGLQMTAARPIAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGETKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYVPGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNYTN", "function": "Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance. In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl. Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function.", "AFDB_id": "AF-P16621-F1-model_v4" }, { "swissprot_id": "Q98SJ5", "sequence": "MKEKSKNAGRTRREKENSEFYELAKLLPLPSAITSQSDKASIIRLTTSYLKMRIVFPEGLGESWGHVSRTTSLENVGRELGSHLLQTLDGFIFVVAPDGKILYISETASVHLGLSQEELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVHEYEMERSFFLRMKCVLAKANAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCDTFHLRCAHHLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQAASTKPSFTYNSPSNPVTENRRVGKSRVSRTKTKTRLSPYSQYPGFPTDRSESDQDSPWGGSPLTDSASPQLLEQCEGIESSCVYRQFSDPRSLCYGLPLTEDHHTSNELYSHPHSESCERGCCKAGRYFLGTPQPGREAWWGAARSVLPLPKSSPENGDSFEGVSPHIASIHSLQVRGHWDEDSAVSSAPDGGSASDSGDRFRADQCRSSPQEPSKIETLIRATQQMIKEEESRLQLRKLPTDVPLEPTNSLAKSFHSTDFPQSAMQSVVCRGPAQVISPAPSPVPLSRLSSPLPDRLSKGKDFLQNELSSSQLPLTGTCAVSPTPALYSLHPRQYLEKHAAYSLTSYALEHLYEADTFRGYSLGCSGSSHYDMTTHLRKAEQAPGHKGTSVIITNGS", "function": "Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.", "AFDB_id": "AF-Q98SJ5-F1-model_v4" }, { "swissprot_id": "C4QVD6", "sequence": "MSCSFQLSLVPSPPNLKMSIRNIINDPFATGSLSLAAMSWIITFISSIVADVQGSFPKLTWWGIVFELFVILFLAVLYIVDDIQPHRLSIVGFLAIATVYTTNSANSLVYSNTSAKNCAAAGSILLSMINLIWLFYYGTDIANSVLVARVFGKQGSNPFTTPQPNRTYTPNDINNTNTNYMSSGQLTGLEKGVDSNAYGNHDDSDDELSADDHYPITVRALYNYDANPEDINELSLKQGEVFKVKDTAGKWWQAKKQSGELGICPSNYVETLH", "function": "Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.", "AFDB_id": "AF-C4QVD6-F1-model_v4" }, { "swissprot_id": "Q9Z2E4", "sequence": "MSTEMMTTEPVPPLELSDDILGKLDPQCSPSDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPAVHIPPFIPGVISEHLIKRYDVQERIPKAKSGPALHNSDMEQKRPRRKDTPALHMPPFVAGLTLLRDESAGVILEDEEMDGDKLAI", "function": "Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.", "AFDB_id": "AF-Q9Z2E4-F1-model_v4" }, { "swissprot_id": "P20036", "sequence": "MRPEDRMFHIRAVILRALSLAFLLSLRGAGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEMFYVDLDKKETVWHLEEFGQAFSFEAQGGLANIAILNNNLNTLIQRSNHTQATNDPPEVTVFPKEPVELGQPNTLICHIDKFFPPVLNVTWLCNGELVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDFYDCRVEHWGLDQPLLKHWEAQEPIQMPETTETVLCALGLVLGLVGIIVGTVLIIKSLRSGHDPRAQGTL", "function": "Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.", "AFDB_id": "AF-P20036-F1-model_v4" }, { "swissprot_id": "Q8H2V6", "sequence": "MAMAAAASLLPASAAPTLPGRAFRPPRNSTPTASLSCDGGSRCRGVGLGVILGGCRAQGVRRNAAAETYVPGSGKYIAPDYLVKKVTAKELEELVRGERKVPLIVDFYATWCGPCVLMAQDIEMLAVEYENNALFVKVDTDDEYELARDMQVRGLPTLYFFSPDQSKDALRTEGLIPIDMIRNIIDNEL", "function": "Probable thiol-disulfide oxidoreductase that may play a role in proper chloroplast development.", "AFDB_id": "AF-Q8H2V6-F1-model_v4" }, { "swissprot_id": "P28150", "sequence": "MKAGFWVAPEGEGAAMTVMPIGAEPPLRARKLNFLATSSAEEMIRRCRRTAMLLPELADALAVQKAEQPGRLFDITDFPDDDRELITQTLGEGEVAGVAALANGVTAQMQEAVMAGVWRIRFTDVDGRLIADYIEVASIPAAVRQACSGLPASISHGPAPAGAMNVMPVLTEIGDRIARYRDGDPAHVITFSLFPMSPEDMAFLQDALGAGPVQLTSRGYGTCRVVATGARNVWSVQFYNAMDTIILDTLEVCNIPSVAIAAEEDFRDSEARLRDIWEAYFK", "function": "Not known. Could enhance the incorporation of nickel to the hydrogenase.", "AFDB_id": "AF-P28150-F1-model_v4" }, { "swissprot_id": "Q60EJ6", "sequence": "MPEAVAAAVSPAAAAATAMCAEHREKLEHIERVTRNAGQEQRRVLEEILAQNAQAEYLRRLGVPGDAPGADEAFRRLAPLVTYEDILPDVLRIANGDTSPILSGKPVSEFLTSSGTSGGERKLMPTIEEEMERRSGLYSLLMPVMSRQVPGLDKGKAMYLYFVKSEWRTPGGLPARPVLTSFYRSRYFLERPHDPYTVYTSPDEAVLCEDAYQSMYAQLICGLVHRADVLRVGAVFASGFLRAIRFLEKHWPSLCRDIRAGELDGGVTDPAVRGAVGRVLRGADPALADAIEAECARPSWQGIIRRVWPSTKYIDVIVTGAMAQYIPTLEFYGGGLPLACTMYASSECYFGLNLNPMCKPSEVAYTLIPTMCYFEFLPVNSGANDVAAPEPDHRGLVDLVDVKLGHEYELVVTTYSGLYRYRVGDVLRVAGFKNAAPMFAFVRRKNVALSIDSDKTDEAELHAAVTEAVQHLAPFGASLVEYTSYADTATTIPGHYVLFWELRSPAGGTPVPASVFEDCCLAVEEGLNSVYRQCRAADRSIGPLEIRVVADGTFDKLMDYALSRGASINQYKAPRCVRPGPVVELLDGRVQATYFSPKCPKWCAGGNKQWISSGAAAKKTTTTCDSLAV", "function": "May catalyze the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.", "AFDB_id": "AF-Q60EJ6-F1-model_v4" }, { "swissprot_id": "Q9P7C8", "sequence": "MEWDADDLLIEPTTEVENDYEDLCTQWVNERMAPDLLPFAEEIVSRVLDRIEAQRETLQLAIGTSSATSYRSVLMQTELERVKFVLRSYMRTRINKIDKYAQYIQSHPNLLLYLSSPERQYLLRHQQIVHRHYMDSFLREVPAKMNKLDDKVGNLSMVASPDMDTAVFCVVNESVEENFRVSENEYITLDKGDVLILRYSVISDYLRLGVVSLI", "function": "The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation and is required for bir1 localization.", "AFDB_id": "AF-Q9P7C8-F1-model_v4" }, { "swissprot_id": "Q9V1Z9", "sequence": "MKPKRVQGKIVIEFPSEDIAEVVYTSVLYEHVSVPYRRSRVNFRREGRRIVLEIEANDSSAMRGTVNSYLRWIKVALDVLNI", "function": "Component of the KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Pcc1 functions as a dimerization module for the complex.", "AFDB_id": "AF-Q9V1Z9-F1-model_v4" }, { "swissprot_id": "Q32P71", "sequence": "MSVAASFPKHTSFTMRASFAAADGLPETENNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQRGEGVFMAARCFWDADTDNCTHDVFMNDSLFCVVAAFGCFYY", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport.", "AFDB_id": "AF-Q32P71-F1-model_v4" }, { "swissprot_id": "Q6F7T9", "sequence": "MEKHIDILIVGAGISGIGIAAHLSKDAPQRQFEIIERRENIGGTWDLFRYPGIRSDSDMSTFGFNFKPWQSPNVLASGSSIKGYLSEVVDEYDLKKKIHFKHRVLAANYDTASKKWYVEIEDAAQKKQTWIANFIVGCTGYYNYDQGFEPDFPNKDAFKGQFIHPQHWPENLDYVGKKVVIIGSGATAITLVPAMSKGGAEHVTMLQRSPTYIASIPSIDFVYDKMRKVLPEDLAYKLTRARNIGVQRGIYTLSQKQPKLVRKFLLKSIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGDLFKILRSGQASVETDQIEKFTETGIQLKSGKHLDADIVVSATGLEIQILGGIKGTIDGQPLDTSKSMLYQGVMVSDVPNMAMIIGYINASWTLKVDVAADYICRLLNYMDKQGYDEVIPEGDQTELMEDTVMGSLTSGYIARAANVMPKQGKHAPWKVTNNYLADRKALKNARFDDGVLHFDKKTDTVERKTKPKLVS", "function": "Is able to catalyze the degradation of n-alkanes with C chain lengths of 32 and 36. Probably allows Acinetobacter baylyi strain ADP1 to grow on the long-chain n-alkane dotriacontane (C32H66) as a sole carbon source.", "AFDB_id": "AF-Q6F7T9-F1-model_v4" }, { "swissprot_id": "O23878", "sequence": "MSTKLILSFSLCLMVLSCSAQLLPWRKGQRSRPHRGHQQFHHQCDVQRLTASEPSRRVRSEAGVTEIWDNDTPEFRCAGFVAVRVVIQPGGLLLPSYSNAPYITFVEQGRGVQGVVVPGCPETFQSESEFEYPQSQRDQRSRQSESEESSRGDQRTRQSESEEFSRGDQRTRQSESEEFSRGDQRTRQSESEEFSRGDQRTRQSESEEFSRGDQHQKIFRIRDGDVIPSPAGVVQWTHNDGDNDLISITLYDANSFQNQLDGNVRNFFLAGQSKQSREDRRSQRQTREEGSDRQSRESDDDEALLEANILTGFQDEILQEIFRNVDQETISKLRGDNDQRGFIVQARDLKLRVPEEYEEELQRERGDRKRGGSGRSNGLEQAFCNLKFKQNVNRPSRADVFNPRAGRINTVNSNNLPILEFIQLSAQHVVLYKNAILGPRWNLNAHSALYVTRGEGRVQVVGDEGRSVFDDNVQRGQILVVPQGFAVVLKAGREGLEWVELKNDDNAITSPIAGKTSVLRAIPVEVLANSYDISTKEAFRLKNGRQEVEVFLPFQSRDEKERERF", "function": "Seed storage protein.", "AFDB_id": "AF-O23878-F1-model_v4" }, { "swissprot_id": "P46435", "sequence": "MNNDDVIWHTINHSFCSFVVKTKTGRFCRNDDNVTGLCNRHSCPLANSQYATIKERDGIIYLFVKEPERIPYPGKQWERIKLRRNKDQALKQIKEHLLYWDKWIISRVKQRFFRTREYLKNMRRLALSRQKKLEPINRTVEKRELRREAKALRVARIERTVEQELLERLRASTSSKEIYNIDQSAFEKALEAEEINEESDEEYEEDEEEIVYTSGSDVEDIEDIGVIDEESEEEEAEHNLVLTNPKKKRKVTIHYEKDE", "function": "Involved in biogenesis of the 60S ribosomal subunit.", "AFDB_id": "AF-P46435-F1-model_v4" }, { "swissprot_id": "Q5L521", "sequence": "MNNRRVLVLGSGVTGKSAAEFLRNRGDYVIGVDGSAEALHSCHFFCERYLDSAEEFPEDIDLCVRSPGIKTSHPFVVEAKHRGIPIVTDIQLAFQDPEFHRYPSLGVTGSAGKTTTVLFLVHLLRSVGMSACAMGNIGFPILQAMYQKGIRVVEISSFQLAEQEIEIPVLSAAAILNISENHLDYHYTLQAYTEAKSHIAKCLQSPESLWVGDGVSFGKSYLEATREINLVLDKGSALKPLYLHDRNNYCAGYALANEVTKIPLESFLQAVLTFDKPPHRIEYLGEKDGVRYINDSKATTMSSVEKALIAVKENIIVILGGRNKGSNFASLIPVLTQTVKHVVAMGECRTEIAQALSSSNLPLTQAQDLQEAVHVAQSIAQPGDVILLSPGCASFDQFRSFEERGDCFKQLVGEMEALKI", "function": "Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).", "AFDB_id": "AF-Q5L521-F1-model_v4" }, { "swissprot_id": "A0R525", "sequence": "MTDEPLGSHVLELQVAEVVEETSDARSLVFTVPEGAEIAADRLRYSPGQFLTLRVPSDRTGSVARCYSLSSSPTTDDRLTVTVKRTADGYASNWLCDNAHAGMRIHVLAPSGTFVPKDLDTDFLLLAAGSGITPMMAICKSALAEGTGNVVLIYANRDENSVIFAGALRELAAKYPDRLTVVHWLETVQGLPTAAGLGALAKPFAGREAFICGPGPFMTAAEDALRAAGTPDDHIHIEVFKSLESDPFAAVVIPEDDGDDQGPATAVVTLDGTTHEIRWPRSAKLLDVLLDKGLDAPFSCREGHCGACAVLKKSGEVHMEINDVLEPSDLEEGLILGCQATPVSDSVEVTYDE", "function": "Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.", "AFDB_id": "AF-A0R525-F1-model_v4" }, { "swissprot_id": "P25042", "sequence": "MNPKSSTPKIPRPKNAFILFRQHYHRILIDEWTAQGVEIPHNSNISKIIGTKWKGLQPEDKAHWENLAEKEKLEHERKYPEYKYKPVRKSKKKQLLLKEIEQQQQQQQKEQQQQKQSQPQLQQPFNNNIVLMKRAHSLSPSSSVSSSNSYQFQLNNDLKRLPIPSVNTSNYMVSRSLSGLPLTHDKTARDLPQLSSQLNSIPYYSAPHDPSTRHHYLNVAQAQPRANSTPQLPFISSIINNSSQTPVTTTTTSTTTATSSPGKFSSSPNSSVLENNRLNSINNSNQYLPPPLLPSLQDFQLDQYQQLKQMGPTYIVKPLSHTRNNLLSTTTPTHHHIPHIPNQNIPLHQIINSSNTEVTAKTSLVSPK", "function": "Transcription factor that represses the expression of HEM13, COX5B, ANB1, CYC7 or AAC3 (hypoxic function). Binds to the DNA sequence 5'-RRRTAACAAGAG-3'.", "AFDB_id": "AF-P25042-F1-model_v4" }, { "swissprot_id": "Q601L4", "sequence": "MNKISEISIQSQKTENLVKFNANDDLPKSLFEQKEPHFQAIFDSILSERASKRLSTHKVKNRAEVSGTGKKPWKQKSTGKARAGSKRSPIFVGGGRAFGPTTQRNYNLKVNKKVKKLAFISALSQLAQNQQILVNDFSMNKISTKLLVDQLKIFKIDQLRHILIASSDPNLFLSARNLPNVELVKTNSLTVESLIKADLLIISKNEITNLEKRI", "function": "Forms part of the polypeptide exit tunnel.", "AFDB_id": "AF-Q601L4-F1-model_v4" }, { "swissprot_id": "Q64323", "sequence": "MANRRGGGQGQPPSVSPSPGSSGNLSDDRTCTHNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVITVTHAYGNRKGVRYLTNGLKVYYLPLRVMYNQSTATTLFHSLPLLRYIFVRERITIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSVITVVVVSRLVYRKGTDLLSGIIPELCQKYQELHFLIGGEGPKRIILEEVRERYQLHDRVQLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTKVGGIPEVLPESLIILCEPSVKSLCDGLEKAIFQVKSGTLPAPENIHNVVKTFYTWRNVAERTEKVYERVSKETVLPMHKRLDRLISHCGPVTGYMFALLAVLSYLFLIFLQWMTPDSFIDVAIDATGPRRAWTHQWPRDKKRDENDKISQSR", "function": "Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.", "AFDB_id": "AF-Q64323-F1-model_v4" }, { "swissprot_id": "P53969", "sequence": "MTSSSGVDNEISLDSPMPIFNESSTLKPIRVAGVVTTGTDHIDPSVLQAYLDDTIMKSITLGQLVKNADVLNKRLCQHHIALNAKQSFHFQGNTYISDEKETHDVVPLMEVVSQLDILPPKTFTAKTGTNFGNDNDAEAYLQFEKLIDKKYLKLPTRVNLEILRGTKIHSSFLFNSYSSLSPQSILNLKVFSQFYNWNTNKGLDIGQRGARLSLRYEPLFLHKLLHNPHSNESPTLFHEWFLETCWRSTKICSQGTSAPYMYSGTMLSQAGDQLRTILGHTFVLDKRDHIMCPTKGSMLKWSNELSPGKHLKTQLELNSVKSWMNDDFITFSTTIKTGYLKNLSSQQSLPVHICDKFQSGGPSDIRGFQTFGLGPRDLYDAVGGDAFVSYGLSVFSRLPWKKVEKSNFRLHWFFNGGKLVNHDNTSLGNCIGQLSKEHSTSTGIGLVLRHPMARFELNFTLPITAHENDLIRKGFQFGLGLAFL", "function": "Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.", "AFDB_id": "AF-P53969-F1-model_v4" }, { "swissprot_id": "P40486", "sequence": "MITPRFSITQDEEFIFLKIFISNIRFSAVGLEIIIQENMIIFHLSPYYLRLRFPHELIDDERSTAQYDSKDECINVKVAKLNKNEYFEDLDLPTKLLARQGDLAGADALTENTDAKKTQKPLIQEVETDGVSNNIKDDVKTIGQMGEGFNWEIEQKMDSSTNNGILKTKYGFDNLYDTVISVSTSNGNDINELDDPEHTDANDRVIERLRKENLKFDPEYYVSEYMTHKYGNEEDLEINGIKELLKFTPSIVKQYLQWYKDSTNPNLVMPIEFTDEEQKQMQDNLPKKSYLVEDIKPLYVTILSVLFSYVFEQIENEGTHTTESAWTMGKLCPQISFLDQQLKQVNELQDGMKEISKVNKDSSLIKIAIITGIRRALSYPLHRNYDLAMKAWTFVYYILRGGKRLVIRALLDIHETFRFHDVYYVYDKVLLDDLTAWFISQGSENVIRSLALEMRKEQESLSKQDIEFECIASFNEQTGEPEWETLNIREMEILAESEYREQQQNPQ", "function": "Involved in the early biogenesis steps of box H/ACA snoRNP assembly.", "AFDB_id": "AF-P40486-F1-model_v4" }, { "swissprot_id": "P54534", "sequence": "MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTTLVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSSPSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV", "function": "S-bacillithiolation is the formation of mixed disulfide bonds between protein thiols and the general thiol reductant bacillithiol (BSH) under oxidative stress. BSH is an equivalent of glutathione (GSH) in Firmicutes. This protein is a dithiol bacilliredoxin, which debacillithiolates (removes BSH) the S-bacillithiolated OhrR (OhrR-SSB) in vitro and in vivo NaOCl-generated S-bacillithiolated MetE (MetE-SSB). Involved in maintaining redox homeostasis in response to disulfide stress conditions.", "AFDB_id": "AF-P54534-F1-model_v4" }, { "swissprot_id": "P30775", "sequence": "MWLSKFQFPSRSIFKGVFLGHKLPLLVRLTSTTTNSKSNGSIPTQYTELSPLLVKQAEKYEAELKDLDKDLSCGIHFDVNKQKHYAKLSALTDTFIEYKEKLNELKSLQEMIVSDPSLRAEAEQEYAELVPQYETTSSRLVNKLLPPHPFADKPSLLELRPGVGGIEAMIFTQNLLDMYIGYANYRKWKYRIISKNENESGSGIIDAILSIEEAGSYDRLRFEAGVHRVQRIPSTETKGRTHTSTAAVVVLPQIGDESAKSIDAYERTFKPGEIRVDIMRASGKGGQHVNTTDSAVRLTHIPSGIVVSMQDERSQHKNKAKAFTILRARLAEKERLEKEEKERKARKSQVSSTNRSDKIRTYNFPQNRITDHRCGFTLLDLPGVLSGERLDEVIEAMSKYDSTERAKELLESN", "function": "Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.", "AFDB_id": "AF-P30775-F1-model_v4" }, { "swissprot_id": "Q94804", "sequence": "MAFKFVVFAAALAYANAGLLGAPAVATYAAGPAVAYSARPAVSTAYINQAAPFLAHAAPLAVAHAAPYAVHAPAVGASHQSVVRSLGGNQAVSHYSKAVDSAFSSVRKFDTRITNDALLRAHAPVAVAHAAPVVVHLTAAHAPVVSSYAHAPLVSSYAAHAPLVSSYAAHAPLVSSYAAHAPVLSTAYAAHAPVVSSYAAPVVARTAAVGYSPAAVVSHTSFTGLGASYAW", "function": "Component of the cuticle of Tenebrio molitor.", "AFDB_id": "AF-Q94804-F1-model_v4" }, { "swissprot_id": "P97352", "sequence": "MAAETLTELEAAIETVVSTFFTFAGREGRKGSLNINEFKELATQQLPHLLKDVGSLDEKMKTLDVNQDSELRFSEYWRLIGELAKEVRKEKALGIRKK", "function": "Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.", "AFDB_id": "AF-P97352-F1-model_v4" }, { "swissprot_id": "A1WVD8", "sequence": "MRLLLDLGNSAIKWAVVPPGGAAWQTGRLAYADGAGPEDTAAALGGRIPSTVAPARICVASVLAPAWQRRFDTALERAWGGPVQHLVASAAAAGVTNGYDQPEQLGVDRWAALIGARAVAPEGACIVDVGTAITVDGLDADGRHLGGAIFPGARLLHQALARGTARLPDSPIGAAALPARSTEEGIAAGVAVGAGAAVTALADAILAACPPGAQRLITGGGGGELAAGLSPAWCHRPYLVLEGLLHWSRHEARR", "function": "Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.", "AFDB_id": "AF-A1WVD8-F1-model_v4" }, { "swissprot_id": "P55885", "sequence": "MRRLCVYVLIFALALAAFSEASWKPCSQLQDAPSGPGANKGLYPHWPDQLDRLGPASHHRRQLGLQGSPHLVADLSKKQGPWLEKEEAAYGWMDFGRRSAEEGDQSP", "function": "Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.", "AFDB_id": "AF-P55885-F1-model_v4" }, { "swissprot_id": "B6K327", "sequence": "MQFGKSLLKHVYTRTFKSSLTCSIFAFTLLMIFFVLDWKRMNVYPRLDEIPGLNVLRAWDDLQEITKSPHPYNSHASDVVRNYILEELYKLKKQDEGNVEVIDDLSSTTTFIMPDTNIRSYFEGSNILVRFRGDNERLRPILLSSHFDSVSTGFGATDNGMGVASALELARYYAEHKPERDLIINFNNAEEDYLYGARAFTEHEWSKNVTAFLNLEGAGAGGKALLFRSTNNHVARSYFKSNRFAFASVLGIDAFKRGVIKSETDYVVYEKMNNGTAGLDLAFFRNRGIYHTERDDIQHTSIFSLNHMLVNAFISLRNLLDEKSQHFKGSSPLYFPVFGSYWQINLNLHLFLNVVFLIACPAILFMCLFRFPSLYAQLKKPCYLICFTLSSLFVLIFDYVVVQSLTKLNPYVIHSSPDAVLAFFFLTNLLGLVYSFRYVATHSRMSNEELSCIEIVLIWYVSMFWYISLLIATLTSIVRGLGSLYFVNFGFFCSFFCCILTLIRVRYFVDRMVTINRPANPEQMPLVQSTSGNAYGTSRYPQHRLKAVVSKSASVKLNDNLWSVLFFSCLVPLPLFTCYNLLSEVFIPAVHQSLIDGPYSNTCYKFAVILVFMAIINSSPFVFRALSKKSSAILLMLWVSLLFNILRAEPFNEKAPIKFRVFQHLNLDTSENLFHVQNIEPYTQKVLNDYPKIISDTSYQCVDRDCFYEAEEPTLGFDGPLQNAINITLHKSLNSSLAELRVDAFETKWCYFDFSVPVYVDSINGFEVQEEHQSLRLGVRNFGTPFVVKTVAKDEDSPTNVTVTCMWDEFDHDKIPSYTSLLNYIPAWSVLTKNSTGLLKMSKTHVM", "function": "May be involved in vacuolar sorting and osmoregulation.", "AFDB_id": "AF-B6K327-F1-model_v4" }, { "swissprot_id": "P64768", "sequence": "MRPEPPHHENAELAAMNLEMLESQPVPEIDTLREEIDRLDAEILALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLGH", "function": "Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.", "AFDB_id": "AF-P64768-F1-model_v4" }, { "swissprot_id": "P0DI12", "sequence": "MDGDELTEQETALYDRQIRVWGAGAQRRLSKSHVLVSGIKGTVAEFCKNIVLAGVGSVTLLDDRLVTTEVFNANFLILPDENAYVGKTVAEICCDSLKDFNPMVHVSIEKGDLSTLGVDFFEKFDVVVIGYSSRATKKAVNEKCRNLAKDVAFYTVDCRGSCGEIFVDLQNYKYTKKKLDETVECELTFPSFEEAVSVPWKPMPRRTAKLYFAMRVIELFEETEGRKPGECSLSDLPRVLKLKKELCEGNSVSENHIPDILLERLVSNNTEFPPACAIIGGILGQEVIKVISGKGEPLKNFFYFDAEDGKGVIEDLSHKL", "function": "The dimeric enzyme acts as an E1 ligase for SUMO1 and SUMO2. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. Functionally redundant with its paralog SAE1A.", "AFDB_id": "AF-P0DI12-F1-model_v4" }, { "swissprot_id": "C5JYV0", "sequence": "MAGPSNQTQPPPPVLTQPSLSFTQGLLVGQLSVVLLIGAFIKFFIFGEAPPHPSRNGLSNRTSSHRRSYSLNSISADSSPRTLREKPSTSNILRPVPSSSTNTRSILRKTYYSATPTNPTSKHSRSRPHHSSHQPESLDWFNVLIAQTIAQYRQTAYILKDSPTSSILASLSEALNNPEKKPSFIDSIKVTDISLGEEFPIFSNCRVIAVEDPNSDGGRLQALMDVDLSDDNLSLAVETSLLLNYPKPFSAVLPVALAVSVVRFSGTLCISFVPGPGTSDQTMSPSPSPPKEASAENIAVDHQSPERQSARQRAPHQHKYTNTNTAGATAAATADDNDTHAKLPHGIPKTSLAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVQAWFEERVVEPRVQVVGLPNIWPRMGRTGVRGSQEETEAGAGGSAPADIPGTAGGDGVGVRGGGGGGGGGGGVGGSGGGSMRGTSGWGMGYDGLRYRHNAHGDGGVGAGPGQSAGAALYGGAQGGGGGGGRGGEEQFAIPGSMPDPVVVT", "function": "Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.", "AFDB_id": "AF-C5JYV0-F1-model_v4" }, { "swissprot_id": "Q8N4C7", "sequence": "MKDRLQELKQRTKEIELSRDSHVSTTETEEQGVFLQQAVIYEREPVAERHLHEIQKLQESINNLADNVQKFGQQQKSLVASMRRFSLLKRESTITKEIKIQAEYINRSLNDLVKEVKKSEVENGPSSVVTRILKSQHAAMFRHFQQIMFIYNDTIAAKQEKCKTFILRQLEVAGKEMSEEDVNDMLHQGKWEVFNESLLTEINITKAQLSEIEQRHKELVNLENQIKDLRDLFIQISLLVEEQGESINNIEMTVNSTKEYVNNTKEKFGLAVKYKKRNPCRVLCCWCCPCCSSK", "function": "Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR).", "AFDB_id": "AF-Q8N4C7-F1-model_v4" }, { "swissprot_id": "Q02374", "sequence": "MAGMSALKRLAPFAHVGGHLFRGRCARAAGARGVRRAGGGAHIEPRYRQFPQLTRSQVIQAEFFSATMWFWILWRFWHDSDAVLGHFPYPDPSQWTDEELGIPPDDED", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.", "AFDB_id": "AF-Q02374-F1-model_v4" }, { "swissprot_id": "A0A7D5JNZ7", "sequence": "MLKINRKYAIILAIVAFSSFQTEAKAASISMLGTASNFGVLGGSTVTNTGPSVITESLGVSTGSSATGFPPAIVNGTIFTSDTVAAQAQVDNATAYNKLASLIPNKDLTGLDLGGLTLTPGVYSFSSSAQLTGILTLDNLGDPNALFVFQIGSTLTTASNSSIVTTNGDAPNVFFQIGSSATLGTGTQFMGNILALTSITLTTGVNIDCGRALAQNGAVTMDTNKVSNACYTKPQEKAVVPEPDSSLAVLGSGLVSLLFAFRKRFRKGW", "function": "A probable ice-binding protein that has ice-structuring activities in vitro. Thought not to anchor the cyanobacterium to ice surfaces, as its habitat is shallow puddles fed by glacier meltwater.", "AFDB_id": "AF-A0A7D5JNZ7-F1-model_v4" }, { "swissprot_id": "Q8VYC8", "sequence": "MGIKYLPVSVASTALSFVGLQVWTELSLDRLRADGLIAKNISLGDSEHALELLLGSYFTIALLTNFVLNVYILLVLSLKTLFFGDLYDVETKKLVERLANYIIYKGTFLPLVIPPTIFQGVLWTVWLTVLCTLKMFQALARDRLERLNASPSSTPWTYFRVYSVLFLVLSVDMFWIKLSLMTYNTIGSAVYLLLLFEPCSIAFETLQALLIHGFQLLDMWINHLAVKNSDCQRSKFIDSMTAGSLLEWKGLLNRNLGFFLDMATLVMALGHYLHIWWLHGIAFHLVDAVLFLNIRALLSAILKRIKGYIKLRIALGALHAALPDATSEELRAYDDECAICREPMAKAKRLHCNHLFHLGCLRSWLDQGLNEVYSCPTCRKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQDLQRTNSVAVTVNNLLQM", "function": "E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN3. Probably not required for RPM1 degradation during HR.", "AFDB_id": "AF-Q8VYC8-F1-model_v4" }, { "swissprot_id": "P05373", "sequence": "MHTAEFLETEPTEISSVLAGGYNHPLLRQWQSERQLTKNMLIFPLFISDNPDDFTEIDSLPNINRIGVNRLKDYLKPLVAKGLRSVILFGVPLIPGTKDPVGTAADDPAGPVIQGIKFIREYFPELYIICDVCLCEYTSHGHCGVLYDDGTINRERSVSRLAAVAVNYAKAGAHCVAPSDMIDGRIRDIKRGLINANLAHKTFVLSYAAKFSGNLYGPFRDAACSAPSNGDRKCYQLPPAGRGLARRALERDMSEGADGIIVKPSTFYLDIMRDASEICKDLPICAYHVSGEYAMLHAAAEKGVVDLKTIAFESHQGFLRAGARLIITYLAPEFLDWLDEEN", "function": "Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.", "AFDB_id": "AF-P05373-F1-model_v4" }, { "swissprot_id": "Q8L838", "sequence": "MPEIEQDDAAAETVDSSTVKFGTPEALEYVRSLTDVGAMTRLLHECIAYQRSLDSDLDTLLSQRTELDRNLVQLQRSAEILDIVKADADHMLGNVRSTCDLADQVSGKVRELDLAQSRVNVTLSRIDAIVERGNCIEGVKTALESEDYESAAKFVQRFLQIDLQYKDSGSDQSEQLHASKEQLEGIAKKKLLAAIDQRDHPTILRFVRLYSPLGMETEGLQLYVGYLKKVIALRGRMEYENVVELMEQGLGQVNFVGCLTNLFKDIVMAIEENDEILRGLCGEDGVAYAICELQEECDLRGSLILKKYMDFRKLAILASDINNSPNLNILPGGASEGPDPREVELYVEEILSLMQLGEDYTEFMVSKIKSLTSVDPELLPTATKAFRNKSFSKAIQDVTRYYVILEGFFMVENVRKAIRIDEHVPDSLTTSMVDDVFYVLQSCLRRAISTSNISSVIAVLSYAGSLLGNDYHEALQQKIREPNLGARLFLGGIGVENTGTEIATALNNMDVSCEYILKLKHEIEEQCTEVFPAPADRERIKSCLSELGELSSTFKQLLNSGMEQLVATVTPRIRPVLDTVATISYELTETEYAENEVNDPWVQRLLHSVETNAAWLQPLMTSNNYDSFLHLIIDFIVKRLEVIMMQKRFSQLGGLQLDRDTRALVSHFSGMTQRTVRDKFARLTQMATILNLEKVSEILDFWGENSGPMTWRLTPAEVRRVLGLRVEFKPESIAALKL", "function": "Required for normal Golgi function.", "AFDB_id": "AF-Q8L838-F1-model_v4" }, { "swissprot_id": "G8G2V6", "sequence": "MVFFKDLFIFKSLIKGSLYSGHMKKKLLNYLPLFALMLFTVSMMAQTAPDEDTNSSIACPSSGVFQNNTTRDVDIANPDNVGTVDDRTCYADYYETSVYGETWGAYNITFNSNHWDAPNTLQPRIERSLSRSQETGVGSYARFTGTLRILEVGNTGTFGSTGSYLMQAKGKHTGGGGSNDPAICLYLARPVYGPDANGNQVQVSFDIWREQINFRGGSGAAGRTEVFLRNVLKDEIIDIELEVGFRQDPNDPNLKIHYSDAIIGGQVFNWNIPEPERGRESGIRYGVYRVKGGRAQMRWANTTYQKVEVVDNSTIPAADIYRIKNVETGEYLTSSGSSIIASTSGTGSDKEWEIISAGSGSSYVNIDSQVRGIIRFTGGSSNPGLVSTNFSPPNTDTDKVWTVIDNNDGTVSFETRNLGRFLYHDTNNMITHSANIDDRSKWNLESTTLSVDSQQIASVGVYPNPTVDGFTISLDNISAEKVQIFNLLGMLVYEQKTNESSIHIDNMDNFDSGMYIISVTANDNKVYQTKLIVN", "function": "Ulvan lyase involved in ulvan degradation. Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall. It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl). Ulvan lyase catalyzes the endolytic cleavage of the glycosidic bond between Rha3S and the uronic acids GlcA or IduA, producing oligosaccharides that have unsaturated 4-deoxy-L-threo-hex-4-enopyranosiduronic acid (deltaUA) at the non-reducing end. This results eventually in the degradation of the ulvan polysaccharide into deltaUA-Rha3S disaccharides and deltaUA-Rha3S-Xyl-Rha3S tetrasaccharides.", "AFDB_id": "AF-G8G2V6-F1-model_v4" }, { "swissprot_id": "Q01356", "sequence": "MDSVPAQTHQGFKEAGAASASHLTTTTSLPTKVESRTAVMEALEDIVYGSAAGIVGKYIEYPFDTVKVRLQSQPDHLPLRYTGPLDCFRQSIRADGFLGLYRGISAPLVGAALENSSLFFFERIGRSLLYSSGFAPRDSELSLSALWFTGGFSGAFTSLILTPVELVKCKIQVPDEPGGAGARQRQLKPIPVIKEIFRHEGLRGFWHGQLGTLIREAGGCAAWFGSKETTSKWFRGRNERALLKRGASQEEVVASRERPLPLWQQAIAGASAGMSYNFLFFPADTVKSRMQTSPIGGGGDNGGKGAATMMPKKSFGEEARALWKQAGIKGFYRGCGITVLRSAPSSAFIFMVYDGLKKYFPMA", "function": "Required for arginine biosynthesis. May participate in the export of matrix-made ornithine into the cytosol (Potential).", "AFDB_id": "AF-Q01356-F1-model_v4" }, { "swissprot_id": "Q8IVM0", "sequence": "MAEVSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAKQLQEEDLKAQAQLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKELQEEKKRKKHFPEFPATRAYADSYYYEDGGMKPRVMKEAVSTPSRMAHRDQEWYDAEIARKLQEEELLATQVDMRAAQVAQDEEIARLLMAEEKKAYKKAKEREKSSLDKRKQDPEWKPKTAKAANSKSKESDEPHHSKNERPARPPPPIMTDGEDADYTHFTNQQSSTRHFSKSESSHKGFHYKH", "function": "Involved in EGFR signaling.", "AFDB_id": "AF-Q8IVM0-F1-model_v4" }, { "swissprot_id": "Q8CAC8", "sequence": "MKLSSLWSNAFVINVAIALYAETAFLSAPKLKIDCRPYLDSNDKCTREYHPVCSTSGKTYCNKCTFCKALRLDTMSSSLLWIKITFILALVVPFYYGTTFAFSKEARRQPDCDKYRTFPNQCTREWNPVCGTNGFTYSNECVFCNAKIAAKEKIDYRHFGPC", "function": "Probable serine protease inhibitor.", "AFDB_id": "AF-Q8CAC8-F1-model_v4" }, { "swissprot_id": "P08738", "sequence": "MADIFRTDKPLAVSPIKTGQPLGAILASLGIEHSIPLVHGAQGCSAFAKVFFIQHFHDPVPLQSTAMDPTSTIMGADGNIFTALDTLCQRNNPQAIVLLSTGLSEAQGSDISRVVRQFREEYPRHKGVAILTVNTPDFYGSMENGFSAVLESVIEQWVPPAPRPAQRNRRVNLLVSHLCSPGDIEWLRRCVEAFGLQPIILPDLAQSMDGHLAQGDFSPLTQGGTPLRQIEQMGQSLCSFAIGVSLHRASSLLAPRCRGEVIALPHLMTLERCDAFIHQLAKISGRAVPEWLERQRGQLQDAMIDCHMWLQGQRMAIAAEGDLLAAWCDFANSQGMQPGPLVAPTGHPSLRQLPVERVVPGDLEDLQTLLCAHPADLLVANSHARDLAEQFALPLVRAGFPLFDKLGEFRRVRQGYSGMRDTLFELANLIRERHHHLAHYRSPLRQNPESSLSTGGAYAAD", "function": "This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).", "AFDB_id": "AF-P08738-F1-model_v4" }, { "swissprot_id": "J4KLU1", "sequence": "MFYTFNAVMTDVVSAGRPARGQSTTTRSRNTQQSAPTSQNFRACRRCRQHRIKCSEKPCEPCRANNSKCVWTEEKPTAAVLTPISPANLAANRPMMAPAAGSTITKPIASHYASPTYTDGEDGGGEPWPLQHPCSCAQHPNTPNSCPSQSGDIRQQQIPCSQHASPASNASKTFHQFLEGLGMAVTAEEGELHQFPPLPSAEEGKTSTAAAGLLPSAPTASETLNWDGQLYFVRLFWMSLAPLFPIMPESEFEALYAADGPYLLGQRTIEGALINGMTALGIQCAEATGSGARILSCSPTAASRSSIEYFRRCRDVLRDQDTSTTTCVHTIRCYILLTLYHLQANQLEKAYYLAGLGVRRAHMGRFHLTPAAHSSARVADDRIRVWWLLSWLDVYCSLQLGRPAAVQRSSNPCPPPSSPPMRFTPMHADVVSRKEASLDNYRFVLSKLTMIVVEALDDVPVFQSLEEMHGSSTAGQSMARLSETIRQLETALDELPEQLLTRHGSRTPTNNGQTHRSRPTCSTMPHTNRQVTSSASSAALTVGLPDWLQRQRLILELHYLDACLVLQRPFVLWKQICSSDASITKHAESAFSRACSVLSMLHSIYSRSDILDRLTMVLPFIWNAIITIAAYVFVGSADDDKKTQLLKAMNNALAILEPLARINPDSLKVYQISQALAAELREASGGTDVVAMPPPPSAATSTSTTFTDDLFKSTFTGSLDLDEFLNDEVTMTDDFSELYSF", "function": "Transcription factor involved in regulation of gene cluster that mediates the biosynthesis of oosporein, a metabolite required for fungal virulence that acts by evading host immunity to facilitate fungal multiplication in insects. Binds oosporein cluster genes at a conserved 5'-CGGA-3' motif with the exception of OpS5. The presence of this motif in the OpS3 promoter would suggest the formation of a positive feedback loop for self-activation.", "AFDB_id": "AF-J4KLU1-F1-model_v4" }, { "swissprot_id": "Q9VK45", "sequence": "MSTTSVVQQFVNGLKSRNRNVQNKATQDLLFYVKTELREMSQEELAQFFDEFDHHIFTMVNATDINEKKGGALAMKCLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADSFDFDIKKAFEVLRGERQEYRRHSAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNELFRCANATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGVAKFASHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALLQILPRLAAFNRAVFVEKYLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKVPVDPAVFACITLLAHAVKSEIADDVKDILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTALPTIAIDGSLMQNGDGATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQSSESMENSKTLSDTVSHVIERLLMVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQDISTAELLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNNLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNELTQSLIQALQVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAKALRYKEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPFW", "function": "Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiation. Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation. Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism. As part of the TORC1 complex regulates energy homeostasis and promotes certain aspects of larval growth by negatively regulating REPTOR. REPTOR functions downstream of TORC1 to regulate the expression of stress response genes in response to TORC1 inhibition resulting from nutrient deprivation. When TORC1 activity is high it phosphorylates REPTOR which inhibits its recruitment into the nucleus and antagonizes their function. This function is essential under normal feeding conditions to promote TORC1-dependent growth during larval development and, in adults and larvae to prevent the REPTOR-dependent expression of nutrient stress response genes. In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology. Rag GTPases act as activators of TORC1 in response to amino acid signals.", "AFDB_id": "AF-Q9VK45-F1-model_v4" }, { "swissprot_id": "P49415", "sequence": "MKPKQKISVEPLLLVAILIGVLVAATHAQDQKSVKPSAAAPSAAASRPHDEIYIDDDSIEGSGGRGGIHEDLEKDPDYSGSGFGPDDEDAEPDQHSHSSHNTRISQSSNSGINTAHTPTQTSSTIPTTSTSTPMPTTTPTATTPASTTTAAATQISSFANSSSTTTTTLAPTIPAEPQQPLFPPFDKDLDTESSGDGIDADAEDDDEDDGDDKDYDYNKELDKEIDIDGPEPGHLPPVVHHNTVETGHIPTTDEIDVDGGDEDDNGDSDIDGPRIGGNDGDITERGPGAGGSNVHELDPNTNVNSQPSDTKGIDHRPNGNEVVIMSEDDRTSSFFSQPGILAAVIGGAVVGLLCAILVVMFIVYRMRKKDEGSYALDEPKRSPANNSYAKNANNREFYA", "function": "Cell surface proteoglycan that bears heparan sulfate. Required for axonal and myotube guidance, is a necessary component of slit/robo signaling and is required in the slit target cells.", "AFDB_id": "AF-P49415-F1-model_v4" }, { "swissprot_id": "Q6CWX7", "sequence": "MRSFIKTHKRASSLDNSPRKSSNESPENRRNSQGSFGTELSYPSGYPPNNVLKQSSSFEPLHKLTSNKIFSSKLFKKSSNGKTSSSNTSPLLSRSDAETFAPLLSNTNNIPAIKGTRKHEWGDNDDTSESVILLNRTSMSSMSDTNQDTPDTEIVRIHPNSQQGSILSSQTSADRTPRLSLEEAEDVEDYDITKHSSLSRSQSLKKKRNRLARIHSHDDIMHLRSQSSFSSDLLGSGFSPIPEKSPNPSPLPKYERSPRKENNILDRTNLFDLRKISEASYTAEDESNFNRPFTGVAGGETIQITTSIKDSFVPSPETSHKIRFAADNVIPLSKAQIIENSASEADEDDSNEEDGEEESDSSSRFSFENGNDLCGRTASLKYYSTETNTPPLYVNDIYENDNFDDEMNYFDSNEEEDENMDHLYGGDNTALSGFAGMCTLSDDEFDRTNAAISQELSSHSSQSSKGYTERQRGFSKRDSNKSFEDGNDDYDPSNHCRSYHDIYNLSDEEEAQTINKKVTEPRKRKISDGTNKVTKYADMFLLSDDDAESGSQDEDFGDESRENDVKFNVNSERYGVEHTNLVTTQNHNLNPISFKSPSRFLDVSNVNHSPLAYKTPERNILKSPLQQPIKYHGVSSLLDNDIQGTMKNLYYIDETDEDRFLENSAESEEYYLDEINGIPEDFEFSDDENIMRNLSPLSRLNRTKLLAFRRTHSYSDRPLGVLKDNTPLNYKLEIKNKTVTFFDHNSIHRSYSEPFSSSLLHDSRKSEDNCEDRILDNKTLASPVTPNSSFTKPSPSFTQNSSLSPIQESTTSSDASPKIL", "function": "Involved in maintenance of polarized growth and daughter-cell-specific transcription.", "AFDB_id": "AF-Q6CWX7-F1-model_v4" }, { "swissprot_id": "O18191", "sequence": "MRKYVLFFISGNNDSQIWATTPNTPRVIARGGLERNIHTRTLARMVNEDAPGTSTPAAQSRLQTTASPFHRTHLTQMCRRGDTNASLLRDFTRMIRDTPRNFSKNTQHGNDRDFGDLERDPDVDLLLSKVCLECVYVEPKEGAIPKANKIFISNFLSDMYINLVSVTGEVMKIIPIWKNAETTRKNLLEKGKHEPCVVDCVDAAFVMKSGITVVLGSDFTTAMFGGNERIAPIFIKEMSNQRVGRKFRLFSFAENRIFAVNEMRCIVVEIPETVTCKSATELMRTCFLHLDRDLSRKLLIKWRSVKRDVDTERLDLDRKEMIDVAIFMLDNVGVRVTNVVAQERADSPEGHGGKQMRPRMSDSEVLSMMRQFFEEMTFRPKSEVITEDGYKCHLSVELDPNGEGFVHTQDLLHAFHSQCEDWSINTMMHSILLELIPYAYLLAKVMNYRAFEEYYVQLFKHLLSQIAIEFKIPPEIHEKFVGAIHIPKPCWSLNNVIAHIICERTTPETMESIPKFISKSSVRLLTILAVGRKFIGMGTNIDMDCERWLGKDWKRRIGLSGDILKSFRRIMNGKSSNSAGRASQLIELFEIGSITIDFMVLAVKVLMLKFQTDAFAGAQSIEPKKCIYATADEMISIAHLRWKNDIRMHNVQLMLNSSRPILIATNILRKNEDDNMKELQDRFLTQTSYRTFSQPFGRAFLDFRTAVPSLLTSIYIPRLNVGGMIYPSRVTCDPPTTEIFKLCTEWGNFYNSLASALRIGSSETVRIDNEWIVMVSKNIKSTAVIGGMTLGFGLNGHLAPFNMYHAHQMLSTFDKFHSVALLIGLSASNFTTCDVQIHKILATYLSFLMGPTPLEIKLDFTIQTAAISGLGLLFADSGNMTIAKKLVNEIGRAPNRDEEPVTDRNAYKLSAGFSLGLIMLGKGNGSASTVIPFKQNIPPMSQRLIYMMNGMRRDKCVFLPQVAPPVVNDVPNLPFSNGGMMTSSQVANHVKESEYINIHQSAEPAAIALGMMFMKMNNEFIANALALPGTITELERLKPDSMYSRVLAQCLVMWDSIEPTHDFVKSLIPPVIREYATAALHFGVPIRRDEDGEEVHEAINDAEEKYWAEIVDKGTVSQTFLYAVSAACMAIALKFSSCGGPNEKNIVNTAFRIIEYYTKIVMPDGKSNKDMGSIRMCIYSGAYTRTSCLSMLITAMAILRVGTGDLEVMRYARLLRLCDKPESDWIATGKKHFEQMVAHQALGILMLGEGRYAFKKDDLSIALTIISTFPTIPQSVSDNSHYHQPLRFLWSMAVEPRLLVPFDIAESCVVEVDVTIVMKPKDGNEPIVYKEKAPYLLPPLEDLQSISIGGGNYQLVHISLQSEDQVKVMKDIMTIGQGRVMLKRYGVDSSEMKIKEATTLYDDTPSLMSMFNNEDTAVELDEYEIQCMMEKIDEGINLNSSDEYPNVQIELSCVRDVTERTTMDLAQLQKRSLKLLSESLDLWQDEVNVSNTINGLADAVQDMQI", "function": "Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion. Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons.", "AFDB_id": "AF-O18191-F1-model_v4" }, { "swissprot_id": "Q61T02", "sequence": "MRGRRQEDIATTSSAPSTSTSHKKKTVSSNGSFRPRTQSNPGGKMEMYDHFYKNFQRPPMAPVYYPTSEEFADPIEYVAKIRPDAERYGVVKIVPPSDFKPPFAIDKEKFTFRPRTQKLNEVEAIVKEKHTFIERLVNFNRYSGLQFEFPVDRDGNVVDLYRLHRIVQNFGGCEEVNDEERWRDVAREYLPKEQMTRGVPSYFINLIRAHYNLHIEPFNRNLKEKAMKNEDESDDELEELKHKYQHHHGTMRSEPENTDGKNTEDVEEECPMSMQSGRRRSKNKKPVPAKKSSNGTPKKGSRGKKNSKTEEDEEENEDVIEQVYCVSCNEGKDEDLLLLCDIEGCNSGRHTYCCDPVLDEVPEGEWRCPKCIESEDAKIGLDWGFYDAETEYNLNTFTEFANKWKCDYFGVDNVSKVSCDALEKEFWKNVVSHDNPVAVKYGADLITSRVGSGFPRKEDKHTGPDSKLKQQYANHAWNLNNMPVLSESVLSYFNTGISGMMVPWVYVGMCFSTFCWHTEDHWTYSVNYNHFGERKIWYGVGGDDAEKFEEALKRLAPGLTGRQRDLFHHMTTAANPSLLRSLGVPIYSVHQNAGEFVITFPRAYHAGYNEGLNFAEAVNFAPIDWLAKGRECVQSYSNVRRYLVFSHDELLFKMIEAMDRLGLSTTLAAYDELKRVIEKQKRLRQFIAQLGVPARNVEQVAFEKIPDEQRSCRFCKTTLFMCALICNKHKRMTCVEHHDHLCKTCTPKDYKYQYRYEIDNLTHLFDELGKRTVDTAGWQEDDDDMYTQEEMPKLEPMVDLYNVEEQSSSRQKNQVHNIIAIQHTAKSAIEKANQLLFKKVRTRTKTRCQRADTRTDADGVKSLIEQMQGMDCNLSGLIDKLQKFLDQIDAWRSKAQIMMSQEHKYSKDDFEHFIEEGDEYDIKLSEIEELRKVVGMKEWSERAIEITSWAPTSNMEKDIDFEYKMRYTNKDVIALIREGSRSSSNHTSQLIAKLQHMLAEANKREAEATEYFDNPSLDKLQSIWKNLRTSDWFYEPYINLVRFEIGQIAKIKSMIDSTIPALSGLDLKPQLLRLGDSSITFAKAVELSKACELSKTLHKSQEHSSLLELINRMNLFTERIAKLFKPMNSYHNLFEIVSERDDLTPLAEGQVLQLYYQGETINSGNEWHQIKDFDSLEQMLHHQSSLREMQSRIFEKVKQTNSARGLEGCCCLGGNKSDSSESVLSCIMCESQFHVRCCEWSTFFQHLPKGCFMCVRCLRGQRPVIDDVANALNGTPSGCMETHLVRNLIQKSRIITQNLMDCSNKRQSGEVASDEMCKKALFDWLACEIMNPNGLPKAVELIHEFFGDYLEKQASAALELQQRPVKSKPSASLFDPKLNSKRKRPNPSQKDSSKSKSRKRQGQISPIDYCEEETEFKSCQARSCLKPFGDSVNWVMCDAGCKNWFHVICVGFTLREINDMHEYRCSSCLDHADSPASSVSTE", "function": "Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Involved in larval development and vulva formation.", "AFDB_id": "AF-Q61T02-F1-model_v4" }, { "swissprot_id": "Q8EWT5", "sequence": "MEKKTTKKATASKTTTTKKAAAEKTEIKETKKTTTTKTSTAKKATTASVEKTEVKETKKSSDNKKEFNPQDRPFAKYNRGYPNKQGRRKKFCKLCAKGQEHVDYKDVELLYKYLTPNLKIASRKITFACSKHQTRVSNAIKRARIVALIPFVRD", "function": "Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.", "AFDB_id": "AF-Q8EWT5-F1-model_v4" }, { "swissprot_id": "Q9GZC8", "sequence": "MIRVYLIILMHLVIGLTQNNSTTPSPIITSSNSSVLVFEISSKMKMIEKKLEANTVHVLRLELDQSFILDLTKVAAEIVDSSKYSKEDGVILEVTVSNGRDSFLLKLPTVYPNLKLYTDGKLLNPLVEQDFGAHRKRHRIGDPHFHQNLIVTVQSRLNADIDYRLHVTHLDRAQYDFLKFKTGQTTKTLSNQKLTFVKPIGFFLNCSEQNISQFHVTLYSEDDICANLITVPANESIYDRSVISDKTHNRRVLSFTKRADIFFTETEISMFKSFRIFVFIAPDDSGCSTNTSRKSFNEKKKISFEFKKLENQSYAVPTALMMIFLTTPCLLFLPIVINIIKNSRKLAPSQSNLISFSPVPSEQRDMDLSHDEQQNTSSELENNGEIPAAENQIVEEITAENQETSVEEGNREIQVKIPLKQDSLSLHGQMLQYPVAIILPVLMHTAIEFHKWTTSTMANRDEMCFHNHACARPLGELRAWNNIITNIGYTLYGAIFIVLSICRRGRHEYSHVFGTYECTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQWFVRHESPSPAYTNILLVGVVSLNFLISAFSKTSYVRFIIAVIHVIVVGSICLAKERSLGSEKLKTRFFIMAFSMGNFAAIVMYLTLSAFHLNQIATYCFIINCIMYLMYYGCMKVLHSERITSKAKLCGALSLLAWAVAGFFFFQDDTDWTRSAAASRALNKPCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLINTRKTSINIF", "function": "Plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa.", "AFDB_id": "AF-Q9GZC8-F1-model_v4" }, { "swissprot_id": "P58330", "sequence": "MTSILTNVAAMAALQTLRGIDSNMEETQARVSSGLRVGTASDNAAYWSIATTMRSDNMALSAVQDALGLGAAKVDTAYAGMENAVEVVKEIRAKLVAATEDGVDKAKIQEEIEQLKQQLTSIATAASFSGENWLQADITTPVTKSVVGSFVRDSSGVVSVKTIDYVLDGNSVLFDTVGDAGILDKIYNVSQASVTLPVNVNGTTTEYTVAAYAVDELIAAGATFDGDSANVTGYTVPAGGIDYNGNFVKVEGTWVRAIDVAATGQEVVYDDGTTKWGVDTTVAGAPAINVVAPASIENIDITNAAQAANLDALIRGVDEALEDLISATSALGSISMRIGMQEEFVSKLTDSIDSGIGRLVDADMNEESTRLKALQTQQQLAIQSLSIANTNSENILQLFRQ", "function": "Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.", "AFDB_id": "AF-P58330-F1-model_v4" }, { "swissprot_id": "P35820", "sequence": "MMTPESKAIQPAAATTKQTAEATATTTMAHTQQKSQLSTLAKTTTTTATNKAAKSVVSNANSSGNNSSKKLALSQSQKTTTTTTPPTTTTTTTAAAAAEATTNADKMQKQQQLKQQLFAACSIKVKSENTLATTANAALAAATTTTTTATPALATGKAAKTILENGIKKESTPPAVESVEASSSSSSSSSSSSSSSSSWPTTRRATSEDASSNGGASADEEKSEEDPTAAVAASSTATTTSDLATTSRPRPVLLTAVNPHIICHLCQGYLINATTIVECLHSFCHSCLINHLRKERFCPRCEMVINNAKPNIKSDTTLQAIVYKLVPGLYERELMRKRAFYKDRPEEAALATPEQRGDDTEHLIFSPSDDMSLSLEYAELGELKTDSEPELVDTLRPRYLQCPAMCRVSHLKKFVYDKFEIDAQRFSIDIMYKVKTIVLLDYYTLMDIAYIYTWKRDAPMRFYYRVYESPQPLVKPAPRRVLPLKLEKQERENQEQQLAVEVASSKVEPVSLPEDQKAEASIKVEEQESTREIVKEVIKDVAATPPTETLKLVINRNMLDKREKSHSPQMSSKSSSKSSPCTPVSSPSEPNIKLKIDLSKQNSVTIIDMSDPERREIVKPLKPEKESRSKKKDKDGSPKSSSSSSSSSSGERKRKSPSPLTVPPLTIRTERIMSPSGVSTLSPRVTSGAFSEDPKSEFLKSFALKPIKVKVESPERTLNNRAITPPSPSVQQSASPKSKGNNLDDSILMKPPSCMPPKSIASSKRKSKEPVKAVSKKQKLSPPLPTVDFKIRLPVTNGNSSGTASPKIEKPLMPPPAKPPMLAPRKLQPSAQFAPPPSPIHHHAGVQMSAPGNRTPIAKRYQPILPKASRPNPFANIPNDVNRLLKDAGTEIKSIGGGSVENNSNAAQKPHLYGPKGESKMGPPALPATTPSQGNKNVGKQAGNLPMSAPPNKGNSSNNYLNLALFNSSKCKGKEAPPGCRTPMYTPNSPIYSPSSPQYVPSYNIPTMPTYKYTPKPTPNSGSGNGGSGSYLQNMLGGGNGGSLGGLFPSPPTKSDQNTNPAQGGGGSSSATQSGGNNGIVNNNIYMPNEDAPEKQQVKVKSLLNSCNINIPSSLSITISRDNGDSSSPNNGQHPKHKSPVNNYIEIVKLPDQPQDQVQAAKEAQKRQSPPAAVPGHLAAKLPPPPPSKAIPSPQHLVSRMTPPQLPKVATPPPPSSPRVITPPKTSPPANAAKVTPLKPVLTPTQVDKKTPSPEKRTAAQMGSHSPTASENKSPKGGPAGVANSTGGAQNGDPAAKKFRPILPRQNGMPELAPKLPTLAPFVGFNPLQNPAAGKKVPPSKKSPNAGAAAHQSGQQKLVNGGQSQPAQQKTSPPAQKNQQQVKKVSKNPTPPPPSLPAVGKMMPHPVMHSQNAPLSIASSASAAAVASGQLDLSNFLKENLRRVHAAQAAQAAQVAAAANQSNMMYNLAQMGHMTPAMYNYQQAYFREQLSRMQRVGNEVFNDYLQKLKTAAATGGGGPVEGELKPMLPTVTLPSPGATPPAASPKTSPLPAGKLTAAATAPQTKGNSSSGAANARQQTAATGNNGATVPAASLPPATKSK", "function": "Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.", "AFDB_id": "AF-P35820-F1-model_v4" }, { "swissprot_id": "P14721", "sequence": "MSPTSLNTSSETAPPSSTTVCVTGAAGFIGSWLVMRLLERGYTVRATVRDPGNMKKVKHLIELPKADTNLTLWKADMTVEGSFDEAIQGCEGVFHLATSMEFDSVDPENEVIKPTIDGMLNIIKSCVQAKTVKKFIFTTSGGTVNVEEHQKPVYDETDSSDMDFINSKKMTGWMYFVSKILAEKAGMEAAKENNIDFISIIPPLVVGPFIMPTFPPSLITALSPITGNEAHYSIIKQCQYVHLDDLCEGHIFLFEYPKAEGRYICSSHDATIYDIAKLITENWPEYHIPDEFEGIDKDIPVVSFSSKKMIGMGFIFKYTLEDMVRGAIDTCREKGMLPYSTKNNKGDEKEPILNSLENNYNIQDKELFPISEEKHINGQENALLSNTQDKELLPTSEEKRVNGLESALLSKIQDKEVLPTSGVKHAKGQENALLPDIANDHTDGRI", "function": "Bifunctional enzyme involved in flavonoid metabolism.", "AFDB_id": "AF-P14721-F1-model_v4" }, { "swissprot_id": "O82039", "sequence": "MAWTEKDVENGKESDSLGNNGFLKGVQSSSDSKGSPVRISPVKKSFEGKDAITYANILRSRNKFVDALAIYESVLQKDSGSIESLIGKGICLQMQNMGRLAFESFAEAIKLDPQNACALTHCGILYKDEGRLVEAAESYQKALKADPSYKPAAECLAIVLTDIGTSLKLAGNSQEGIQKYYEAIKIDSHYAPAYYNLGVVYSEMMQYDMALNCYEKAAIERPMYAEAYCNMGVIYKNRGDLESAIACYERCLAVSPNFEIAKNNMAIALTDLGTKVKLEGDINQGVAYYKKALYYNWHYADAMYNLGVAYGEMLKFDMAIVFYELAFHFNPHCAEACNNLGVIYKDRDNLDKAVECYQMALTIKPNFSQSLNNLGVVYTVQGKMDAAASMIEKAIIANPTYAEAYNNLGVLYRDAGNISLAIEAYEQCLKIDPDSRNAGQNRLLAMNYINEGSDDKLYEAHRDWGWRFMRLYQQYNSWDNSKDPERQLVIGYVSPDYFTHSVSYFIEAPLAYHDYANYKVVIYSAVVKADAKTNRFRDKVLKKGGVWRDIYGIDEKKVSSMIREDKVDIMIELTGHTANNKLGMMACRPAPVQVTWIGYPNTTGLPTIDYRITDSMADPPSTKQKHVEELVRLPDSFLCYTPSPEAGPVSPAPALTNGFVTFGSFNNLAKITPKVLQVWARILCAVPHSRLIVKCKPFGCDSVRQRFLSILEQLGLEPQRVDLVPLILLNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMGGSVHAHNVGVSLLKTVGLRKLVARNEDEYVELAIQLASDVTSLSNLRMSLRELMAKSPLCDGAQFTQNLESTYRSMWRRYCDGDVPSLRRMELLQQQQQTLAELVVPEESPVSPIEKTRISASKDGPIKENGFTVSPALVYNSSTIEENGVQLNQAGNPGKQS", "function": "Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins.", "AFDB_id": "AF-O82039-F1-model_v4" }, { "swissprot_id": "G5ECG0", "sequence": "MSLNTTFTKEDGTEVVIPFNGSQNGHPENEEPEVEEAAEPSSSVETLCGATRGDIIVMKHTTKALTELIERLLHSDEFEVRRCSNGQIISQGRCNGTTPGNGIGGGGASSEELEKALKDRDAARAEADKLHANYATLFASFNTVREAANDIRGEYEDARDKLKLAAAEVDEWQAKFLAVKDNANSELERASVEYDDLLRSHDENTKGLRLRVKRQEIELSSKNDEIKVLTNRVSELSQICDQLLNDVDVSDGMSVISTDA", "function": "Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is required for mitotic spindle positioning in one-cell stage embryos. The complex acts in a partially redundant manner with the tac-1/zyg-8 complex to regulate microtubule assembly and processes during interphase, mitosis and meiosis in embryos. Plays a role in injury-induced axonal regrowth, regeneration and microtubule stability in PLM neurons and this may be downstream of efa-6.", "AFDB_id": "AF-G5ECG0-F1-model_v4" }, { "swissprot_id": "A7ZIA5", "sequence": "MPSTPEEKKKVLTRVRRIRGQIDALERSLEGDAECRAILQQIAAVRGAANGLMAEVLESHIRETFDRNDCYSREVSQSVDDTIELVRAYLK", "function": "Repressor of the frmRAB operon.", "AFDB_id": "AF-A7ZIA5-F1-model_v4" }, { "swissprot_id": "Q93212", "sequence": "MCRRAEDLVLLLIPILFGYFSHASEHECKCVLFNVTSGNFHSPEFPAPLEGVPCLFYHFQAPPDHIIRLTFDVFQLPPRIGVCSSSIMLFDHSTDGLIEFGERADFEFCGKEISSGRQFFSKDQHFLLQISSGKESSRGFRGSFLAIPKKNFTSDAVEMAECSYRVEKQKAIIYSPDYPYYYPSKVNCTYHIPQRKGFQIVVNSIVMDIGRDAILQIFESVEGKFEKRLIEMVTSVQKSIYVSSTSSLLIYFSAGNNDVERAVGFVIELQYSNAVWSQSPETASECQLNINSENFKEGQLSSDKIGRFTSSSLPTKCQIVLQGYPNEKISVKFTHFNLYVPDNKNVTKRCTEVDNLSADVRVGSRLSRIDEWCGKRAPPNLMSSSNLLQLEYNTKSSKAIRESTNDDIGFRLDYKFHTDWNMGNMKAKVDKKKECRFSFNSSEHTNGKLWSANYPGLYPRNLYCEYIFHGRNDQVVHIHFEYFDIEGFNQCDETTQSDYILFSNYQTHDRTNRRFCGKTAPKGPILSESNYFRMIFSTNDIFDATGFYAHYQFITQEKSQISRVKLTISSSQTPFSSFFLVILLFTFRYIANIF", "function": "Accessory protein required for glutamate-gated currents. May participate in the gating of non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors such as glr-1.", "AFDB_id": "AF-Q93212-F1-model_v4" }, { "swissprot_id": "Q9SXJ7", "sequence": "MAWSIALLTPPFFGPGRHVQAKEYREPRGCVMKMSSLKAPVLRIQATEYREPRGRVKMMSSLQAPLLTIQSFSGLRAPSALDYLGRPSPGFLVKYKLAKSSGREKASRCVPKAMFERFTEKAIKVIMLSQEEARRLGHNFVGTEQILLGLIGEGTGIAAKVLKSMGINLKDSRVEVEKIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIGSEHLLLGLLREGEGVAARVLENLGADPSNIRTQVIRMVGENNEVTASVGGGSSGNSKMPTLEEYGTNLTKLAEEGKLDPVVGRQPQIERVVQILARRTKNNPCLIGEPGVGKTAIAEGLAQRIASGDVPETIEGKTVITLDMGLLVAGTKYRGEFEERLKKLMEEIRQSDEIILFIDEVHTLIGAGAAEGAIDAANILKPALARGELQCIGATTIDEYRKHIEKDPALERRFQPVKVPEPTVEEAIQILQGLRERYEIHHKLRYTDEALVAAAQLSHQYISDRFLPDKAIDLIDEAGSRVRLRHAQLPEEARELEKQLRQITKEKNEAVRSQDFEMAGSHRDREIELKAEIANVLSRGKEVAKAENEAEEGGPTVTESDIQHIVATWTGIPVEKVSSDESSRLLQMEQTLHTRVIGQDEAVKAISRAIRRARVGLKNPNRPIASFIFSGPTGVGKSELAKALAAYYFGSEEAMIRLDMSEFMERHTVSKLIGSPPGYVGYTEGGQLTEAVRRRPYTLVLFDEIEKAHPDVFNMMLQILEDGRLTDSKGRTVDFKNTLLIMTSNVGSSVIEKGGRRIGFDLDHDEKDSSYNRIKSLVTEELKQYFRPEFLNRLDEMIVFRQLTKLEVKEIADIMLKEVVARLEVKEIELQVTERFKERVVDEGFDPSYGARPLRRAIMRLLEDSMAEKMLSRDIKEGDSVIVDVDAEGSVVVLSGTTGRVGGFAAEEAMEDPIPIL", "function": "Molecular chaperone. May act as a suppressor of FtsH-mediated thylakoid membrane biogenesis and may enhance photoinhibition. Seems not involved in chloroplastic protein import. Probable component of the TIC-associated stromal import motor involved in inner membrane translocation. Has an ATPase activity, but no ADPase activity. Interacts with transit peptides with a positional preference. Localization of the signal sequence at the N-terminal end of a protein seems mandatory for interaction to take place.", "AFDB_id": "AF-Q9SXJ7-F1-model_v4" }, { "swissprot_id": "P54964", "sequence": "MKWLLFPARIVARTRPNLFSLYRRSVSQYLRPRTIQNLQSMAQTPELKTKLFKPLVWIDCEMTGLDHVNDRIIEICCIITDGHLAPVKAADGQGDSHYESVIHYGPEVMNKMNEWCIEHHGNSGLTAKVLASEKTLAQVEDELLEYIQRYIPDKNVGVLAGNSVHMDRLFMVREFPKVIDHLFYRIVDVSSIMEVARRHNPALQARNPKKEAAHTAYSDIKESIAQLQWYMDNYLKPPQETESVESIGSEQPESPSSSTSSLKRQRTDF", "function": "3'-to-5' exoribonuclease specific for small oligoribonucleotides.", "AFDB_id": "AF-P54964-F1-model_v4" }, { "swissprot_id": "A4IT50", "sequence": "MKVHEANQGLTLPGSVVAIGAFDGVHQGHQAVLRQAVERSRQLGVESVAYTIDPPPRCRFQGSRMLTTLQEKLDRFAVLGLNHAVVAHFDERYAARRVDAFIRELTALNPREVIVGQDFRFGRNREGDVALLRRHFPVRIVQTVCCADGQRISSTRIRELIERGEWEQSTVLLGWPLSS", "function": "Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.", "AFDB_id": "AF-A4IT50-F1-model_v4" }, { "swissprot_id": "Q62130", "sequence": "MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSRLQQEATRYQYYLQVKKDVLEGRLRCSLEQVIRLAGLAVQADFGDYNQFDSQEFLREYVLFPMDLAMEEAALEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDSHGNSVHLGIFFMGIFVRNRVGRQAVIYRWNDIGSVTHSKAAILLELIDKEETALFHTDDIENAKYISRLFTTRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPMHVQCSEHYSETHTSQDSIFPGNEEALYCRSHNSLDLNYLNGTVTNGSVCSVHSVNSLSCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSTIIVPSYRPTPDYETVMRQMKRGLMHADSQSRSLRNLNIINTHAYNQPEELVYSQPEMRERHPYTVPYAHQGCYGHKLVSPSDQMNPQNCAMPIKPGASSISHTVSTPELANMQLQGAQHYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGGGGGTVNKRHSLEVMNSMVRGMEAMTLKSLNIPMARRNTLREQGPSEETGGHEVHGLPQYHHKKTFSDATMLIHSSESEEEEETLEAAPQVPVLREKVEYSAQLQAALARIPNRPPPEYPGPRKSVSNGALRQDQGTPLPAMARCRVLRHGPSKALSVSRAEQLAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMTGPQAQKRPLMLAALNGLSVARVSGREDGHHDATRVPIDERLRALKKKLEDGMVFTEYEQIPNKKANGVFSTATLPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGSEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSGCYATTGLKVKHLLSGQERTVWHLQYTDWPHHGCPEDVQGFLSYLEEIQSVRRHTNSVLEGIRTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHNEKVEVPTMLRFLREQRMFMIQTIAQYKFVYQVLVQFLQNSRLI", "function": "Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.", "AFDB_id": "AF-Q62130-F1-model_v4" }, { "swissprot_id": "Q8VZG7", "sequence": "MATGAENQWLKGRVKAVTSGDCLVITALSHNRAGPPPEKTITFSSLMAPKMARRGGIDEPFAWESKEFLRKLCIGKEVAFKVDYKVEAIAGREFGSVFLGNENLAKLVVKTGWAKVREPGQQNQDKVSPYIKELLQLEELAKQEGYGRWSKVPGAAEASIRNLPPSAIGDSAGFDAMGLLAANKGKPMEGIVEQVRDGSTIRVYLLPEFQFVQVFVAGVQAPSMGRRTTNGSVVETVPDEPNGDVSAESRGPLTTAQRLAASAASSVEVSSDPFATEAKYFTEHRVLSRDVRIVLEGVDKFNNLIGSVHYSDGETVKDLGLELVENGLAKFVEWSANMMEEEAKKKLKAAELQCKKDKVKMWANYVPPATNSKAIHDQNFTGKVVEVVSGDCLIVADDAVPFGSPAAERRVCLSSIRSPKMGNPRREEKPAPYAREAREFLRQRLIGKQVIVQMEYSRKVTQGDGPTTSGAADRFMDFGSVFLPSAAKADSDEVTAPPAAAIAGSQPVGVNIAELVLVRGFGNVVRHRDFEERSNHYDALLAAEARALAGKKGIHSAKESPAMHITDLTVSAAKKAKDFLPSLQRIRRIPAVVEYVLSGHRFKLYIPKITCSIAFSFSGVRCPGRGEPYSEEAISVMRRRIMQRDVEIEVETVDRTGTFLGSMWESRTNVATVLLEAGLAKMQTSFGADRIAEAHLLEQAERSAKNQKLKIWENYVEGEEVSNGNTNTVETRQKETLKVVVTEVLGGGRFYVQSAGDQKIASIQNQLASLSIKDAPIIGSFNPKRGDIVLAQFSLDNSWNRAMIVTAPRAAVQSPDEKFEVFYIDYGNQETVPYSAIRPIDPSVSAAPGLAQLCRLAYIKVPSLEDDFGPEAGEYLHTVTLGSGKEFKAVIEERDTSGGKVKGQGTGTEFVVTLIAVDDEISVNAAMLQEGIARMEKRQKWGHKGKQAALDALEKFQEEARKSRIGIWQYGDIESDDEDTGPARKPAGGRR", "function": "Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress. Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e.g. salt and heat). Involved in gibberellic acid (GA) biosynthesis. Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway. Component of stress granules (SGs) that regulates growth under salt stress by modulating levels of GA20OX3 mRNA. Binds GA20OX3 mRNA. May inhibit the degradation of mRNAs involved in stress adaptation.", "AFDB_id": "AF-Q8VZG7-F1-model_v4" }, { "swissprot_id": "Q54QG0", "sequence": "MNDSPIISVVLPFLIKDNDDKSLNYQGINNLIISIDSIIEQTFKEWELILVDDGSNNEILEQLLSKRYSTDNRIKFIINKENKGIVKSLNDAILNHCSPTSKYIARMDSDDISHPTRLQSQLKYLQSNETIDILGCPIKMFNNNKLIEILNNNNNNNNINNNVKELINIINNEESFKFIQHPDKDILMWSMFFNCCIVHPSVIFKRSIFTIEHCYEENNQFPFIEDYLFWLKSLIMKGLNISNIQSSTPLLYLRKHNNSISFKNIEKQKDSTANASCYYLNILFKRFNIDSEIIQNSSLSMKEIIQFFQLSPSSLSKINNISIELFEFAFKYLELIEKSCTKQQPNYSNSIKDAANEKMGELVSLCLSNYPNNQKSSLLWEKWLSRNPTSQLLSLLSNLNVKSSTTIINNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNSILNFISGINSNKINTPKSNNNKFKENGIRIICFSKDRAFQLKEYLRTFFKYLKNDDNGNDKFEIIVDVLFTYSNEKFKNSYQLVIESFPQVNFIKEENFTDQLINLVQKTNKLEYVMFSVDDILYYNEFNLKEYCLSLNSEPLALGFYMKLNKNITYCHTCNQDITIPLNSNTISRTENNFKYLKWNRNDNDCKKDWNYPWDLCSTIYRCNDIDSIINGIVKYYGIRNGINHPNRFEFNGNRPIIQKQIYQNKPYCLCLSDHYSPMSVVTINRVQDVYDNPIYDQTLSLDDLDQLLYSNKSLNDEKYKENSLSLNFKSVHIGELFIS", "function": "Bifunctional protein composed of 2 glycosyltransferase domains involved in glycosylating skp1. The N-terminal part catalyzes the transfer of a galactose residue to GlcNAc-skp1 in a beta 1-3 linkage. The C-terminal part catalyzes the transfer of a fucose residue to Gal-GlcNAc-skp1 in an alpha 1-2 linkage.", "AFDB_id": "AF-Q54QG0-F1-model_v4" }, { "swissprot_id": "B6HLP6", "sequence": "MARILITGSTDGFGLEAARQLVDRKHVVYLHARSQERAEEVKTKCPGAAGVLVADLTSVAETRKLAEEANAIGTFDAIILNAGLLYGPFRKTDYGVPAMPFVNVLAPYILSCLLEQPKRLIFIASILHKEAKTDLKDIFWLERGEKEFQDFPAYCDSKFHVMLLANAVAKRFKGTSVTSVHPGYVATKLGGSGATDKMEDGVETYVMLAEGDYDQSLTGVYFVPKKQIGEPLPETTQEDLQETVVKACEDITGIKLPA", "function": "Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine. the NRPS chyA mediates the condensation of anthranilic acid and alanine into the intermediate 2-(2-aminopropanamido)benzoic acid. The remainder of the pathway is highly branched yielding at least 13 chrysogine-related compounds. The malonyl transferase chyE converts 2-(2-aminopropanamido)benzoic acid and 2-(2-aminopropanamido)benzamidine into 2-(2-(2-carboxyacetamido)propanamido)benzoic acid and 3-((1-((2-carbamoylphenyl)amino)-1-oxopropan-2-yl)amino)-3-oxopropanoic acid, respectively. ChyD is an amidase, being responsible for the amidation of the carboxylic acid moiety of 2-(2-aminopropanamido)benzoic acid, 2-(2-(2-carboxyacetamido)propanamido)benzoic acid and 2-(2-((4-amino-1-carboxy-4-oxobutyl)amino)propanamido)benzoic acid. ChyC is involved in the same reactions as ChyD, but plays a more minor role in the amidation reactions compared to chyD. The oxidoreductases chyH and chyM are involved in oxidation reactions that form N-pyruvoylanthranilamide from 2-(2-aminopropanamido)benzamidine and (1-((2-carbamoylphenyl)amino)-1-oxopropan-2-yl)glutamine, respectively. N-pyruvoylanthranilamide is further converted via two further branches in the pathway, yielding chrysogine and additional chrysogine-related coumpounds. Chrysogine is likely formed by a spontaneous ring closure from N-pyruvoylanthranilamide.", "AFDB_id": "AF-B6HLP6-F1-model_v4" }, { "swissprot_id": "P51485", "sequence": "MVDEDKKSGTRVFKKTSPNGKITTYLGKRDFIDRGDYVDLIDGMVLIDEEYIKDNRKVTAHLLAAFRYGREDLDVLGLTFRKDLISETFQVYPQTDKSISRPLSRLQERLKRKLGANAFPFWFEVAPKSASSVTLQPAPGDTGKPCGVDYELKTFVAVTDGSSGEKPKKSALSNTVRLAIRKLTYAPFESRPQPMVDVSKYFMMSSGLLHMEVSLDKEMYYHGESISVNVHIQNNSNKTVKKLKIYIIQVADICLFTTASYSCEVARIESNEGFPVGPGGTLSKVFAVCPLLSNNKDKRGLALDGQLKHEDTNLASSTILDSKTSKESLGIVVQYRVKVRAVLGPLNGELFAELPFTLTHSKPPESPERTDRGLPSIEATNGSEPVDIDLIQLHEELEPRYDDDLIFEDFARMRLHGNDSEDQPSPSANLPPSLL", "function": "Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying.", "AFDB_id": "AF-P51485-F1-model_v4" }, { "swissprot_id": "O29104", "sequence": "MPLDKVLQEIQQKGEEEVRRIREETEKEVEKILAEAKAEAEEILKKAREEAEKEAEAIRRQEISSVKLEMKRELLNVQKEILEEVFNLLRQKVRDMDEETRKKILKNLLEKNASPGMVVYSRKEDEDIVKELIKELKLDVTYGGNIDCIGGVILEDPAGDIRLNLTFDELVSQVYEQKLSEVSKLLFK", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-O29104-F1-model_v4" }, { "swissprot_id": "P34750", "sequence": "MNSGLSRLGIALLAAMFAPALLAADLEKLDVAALPGDRVELKLQFDEPVAAPRGYTIEQPARIALDLPGVQNKLGTKNRELSVGNTRSVTVVEAKDRTRLIINLTALSSYTTRVEGNNLFVVVGNSPAGASVASAAPVKASPAPASYAQPIKPKPYVPAGRAIRNIDFQRGEKGEGNVVIDLSDPTLSPDIQEQGGKIRLDFAKTQLPDALRVRLDVKDFATPVQFVNASAQSDRTSITIEPSGLYDYLVYQTDNRLTVSIKPMTTEDAERRKKDNFAYTGEKLSLNFQDIDVRSVLQLIADFTDLNLVASDTVQGNITLRLQNVPWDQALDLVLKTKGLDKRKLGNVLLVAPADEIAARERQELEAQKQIAELAPLRRELIQVNYAKAADIAKLFQSVTSDGGQEGKEGGRGSITVDDRTNSIIAYQPQERLDELRRIVSQLDIPVRQVMIEARIVEANVGYDKSLGVRWGGAYHKGNWSGYGKDGNIGIKDEDGMNCGPIAGSCTFPTTGTSKSPSPFVDLGAKDATSGIGIGFITDNIILDLQLSAMEKTGNGEIVSQPKVVTSDKETAKILKGSEVPYQEASSSGATSTSFKEAALSLEVTPQITPDNRIIVEVKVTKDAPDYQNMLNGVPPINKNEVNAKILVNDGETIVIGGVFSNEQSKSVEKVPFLGELPYLGRLFRRDTVTDRKNELLVFLTPRIMNNQAIAIGR", "function": "Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane.", "AFDB_id": "AF-P34750-F1-model_v4" }, { "swissprot_id": "E9AD19", "sequence": "MHRVQNVQSHVGEYAPDILVVGSCFLDYVGYVDHMPQVGETMHSESFHKGFGGKGANQAVAAGRLGAKVAMVSMVGTDGDGSDYIKELERNGVHTAYMLRTGKSSTGLAMILVDTKSSNNEIVICPNATNYFTPELLRAQTSNYEKILHTGLKYLICQNEIPLPTTLDTIKEAHSRGVYTVFNSAPAPKPAEVEQIKPFLPYVSLFCPNEVEAALITGMKVTDTESAFRAIKALQQLGVRDVVITLGAAGFALSENGAEPVHVTGKHVKAVDTTGAGDCFVGSMVYFMSRGRNLLEACKRANECAAISVTRKGTQLSYPHPSELPAGVT", "function": "Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. Specifically phosphorylates D-ribose. Fails to phosphorylate 4, 5 or 6 D-carbon sugars (erythrose, threose, xylulose, arabinose, fructose and glucose).", "AFDB_id": "AF-E9AD19-F1-model_v4" }, { "swissprot_id": "A8MCY4", "sequence": "MHVFGLIGYPLNYTLSPQIHNYVFKRLRIDAAYVPLRVASKRLLHFIEFSRDALSGFNVTIPHKVAVAKLIDELNDDADTIKSVNTVVNSNQKLIGYNTDYVAVEESLIERGYKGEEALLIGAGGAARAVVLALSKTGCRAIKVLNRSRERAVELCGLANGLGLDCSVVDIGGNYGKPHVIINATPLSSEEYWLLNLGELGTMLLLDMAYKPNTETDLIKRARELGIQVIDGVEILVRQALAADKLWLGDFNEPSASEVIKYIKGINPS", "function": "Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).", "AFDB_id": "AF-A8MCY4-F1-model_v4" }, { "swissprot_id": "C6D5D2", "sequence": "MTEFVPLTWHDTLYLAPELILAAMFLILIVTDLILPGRTNRAIIGWLSLAGLLLSLAAVIWRMIDMNPSGVSAAEAAEAGKAISLLGASYRVDDYGNLLKIIFLIGTSLVVLLGLGSTQKDDAVTDKAEFYYLLLPAAAGAMIMASSGNLVTLYIGLELLSITTYVLVGLRKRSSLSAEAAFKYVVTGGIASAFVLFGMSYLYGVTGSVSLADFPTALPQAFTDYKALVYVGFFFLIAGFGIKIAAAPFHIWAADVYQGAPTPVSAFLAVIAKGAALAAVFRFLYSSAFFLTGGPGKQAGDDVFFALLVIAAAAMIAGTVSALRQKQVKRLLALSGVANAGYLLVPIAISVTIIHSNNFSEFVFYLVAYLLMNVGAFAVVTVIARAAGHEELKGFSGLYYRAPWTAAAMLIFILSFSGLPVTAGFFGKLFILLGAASVKAYWLVAIMVVSTVISYYFYFGIIRQMFMRSNGEEEDRIHVPAVTGTVIWICAAATVALGVLPGPLMKWIDAVFTIQADLFVR", "function": "NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-C6D5D2-F1-model_v4" }, { "swissprot_id": "D4ANU4", "sequence": "MKLSLLTVAAAAGAAVAAPAAEIDTRAGSVQGFDISGYQPNVDFRAAYNGGARFVMIKATEGTTFKSSTFNSQYTGATNNKFIRGGYHFAHPDTSATAQCDYFLANGGGWSNDGITLPGMIDLEGTSGKPKCYGLSASAMIAWIKAFSDRYNAKTGRYPMIYTSPDWWQSCTGNTKTFGTTIPLVLARWASSPGTPPGGWPYHTFWQNADTYRFGGDSEIFNGGMDQLQRFAKGG", "function": "This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.", "AFDB_id": "AF-D4ANU4-F1-model_v4" }, { "swissprot_id": "Q54HI0", "sequence": "MTDDYSKLKSEIMDLVSEEFLKTKDDIISVMIENNKLKRAELVVGNDSLPPPPPTPSIVKIEHTTTTSNIDDLPLPPPIQEVEEEEPTQQNIEQQQQTQDESDDYYKTVHPLGVQDTYEDEEYFSSYSKISLHHEMVFDKRRTAAYYHAISKSKNIFKDKVVLDVGCGTGILSCFVAKAGAKKVYAVDASDMAHRAELIVQQNGLADIVTVFKGKLEHIAFPEYVDVIVSEWQGAFLIFESMIESVIYARDNLMRPGGIILPSKASIYLSPINVDSFYNQYINQWSNVFNLDMSPLIPFAQEELLEEKTIRNYYVDNQDSVLDKPIILRTIDLSTITIEDLSKTVKTFEFQVPNGSKYHGFGSWFSVWFENLDDDDDDNDNNNNNNDNSNDDENKQQFAYYTIDRDGELVKSTYQQYSIDSKGLTPLFFKQSSNVLELSTAPGTGDQHWKQVLFLNSKEKILQSSDKQLDTTSIKGTIRILQNKDYRRHWWIEMYVSLKTNPFDYSYQKYLI", "function": "Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in some proteins such as histones.", "AFDB_id": "AF-Q54HI0-F1-model_v4" }, { "swissprot_id": "P07103", "sequence": "MPLSYLDKNPVIDSKKHALRKKLFLSCAYFGLSLACLSSNAWASVEPLSVNGNKIYAGEKAKSFAGNSLFWSNNGWGGEKFYTADTVASLKKDWKSSIVRAAMGVQESGGYLQDPAGNKAKVERVVDAAIANDMYAIIGWHSHSAENNRSEAIRFFQEMARKYGNKPNVIYEIYNEPLQVSWSNTIKPYAEAVISAIRAIDPDNLIIVGTPSWSQNVDEASRDPINAKNIAYTLHFYAGTHGESLRNKARQALNNGIALFVTEWGTVNADGNGGVNQTETDAWVTFMRDNNISNANWALNDKNEGASTYYPDSKNLTESGKKVKSIIQSWPYKAGSAASATTDPSTDTTTDTTVDEPTTTDTPATADCANANVYPNWVSKDWAGGQPTHNEAGQSIVYKGNLYTANWYTASVPGSDSSWTQVGSCN", "function": "Represents 97% of the global cellulase activity.", "AFDB_id": "AF-P07103-F1-model_v4" }, { "swissprot_id": "P18407", "sequence": "MTDIDYKLEAVPATRIAADDIDKTFRSSTIDLISGALGGKVLGFSDEWFAEAANLLTPTAPIRQPGKMVYTGAWYDGWETRRHNPAEFDWVVIRLGVASGTVEGVEIDTAFFNGNHAPAISVEGCFSQNDDEVLSWKGERGGWETILGVQECGPSQRFGWKLENPTKKQYTHVRLNMYPDGGIARFRLFGHAVPVFPDNTDAIFDLAAAQNGGVAISCSDQHFGTKDNLILPGRGKDMGDGWETARSRTKGHVDWTIIRLGAPGYIQNFMVDTAHFRGNYPQQVKLQAIEWKSEGEPGADSEGWTEVVEPIKCGPDQEHPVESLVKDKPFTHVKLIIVPDGGVKRLRVFAKRAV", "function": "Utilization of purines as secondary nitrogen sources, when primary sources are limiting.", "AFDB_id": "AF-P18407-F1-model_v4" }, { "swissprot_id": "A4QTI0", "sequence": "MSLRSWFRGSGTTTPKSSAGPSRATTPPSGVQGTVMTAEQQELADLSDAMQAMAHIMNDDPESAEAHLRQRKDPSSFHLLGLGVSIFMRSILGFEKDVMAEASKCIADCETRSWNDKVKGERREPATDGRLFPNGSEFAIVYAQALLMNAVVSVLHESLTDALKAFYKLRKAMAVMSSISAAEEKIMKEQGASSARGNPFEQASTASGSGNLAAEDEDSDLEFVDADEKVSPEAPIHVTYDGHTSTKDSTSQPATDAATLEGKLQALEIPDDSDTKSHLSKSAVESQVPSLSASRAPSPGPPPQLTDAASDGSLFTHPIDIFIHSAINMCYGSLMLVLSMVPPAFSRLLGIIGFRGDRDKGLHMLWQSAAHPNMNGAVAGLLLLGYYHGLLAFADVLPSERDVAELAEPDEIVGYPRGRCIELLRVMRERYPASGLWRMEQARVLIGEKKLKEGIEMLEKCGDAKMRQVTALSTFELAVSSICYLDWPRMHSSFVRMVELNDWSHALYYFIAGCAHLEMYRDAVHELGGLSELSEDGSESEKEVKAGDVKVTATKDRLDVEDIRKKELISNARKYKKSAETLFRKAPTTAGRKRFMARQMPFEVFVMRKVAKWEERATALKLDLADAIGPSPAAEMIYLWNGGKRMNLELIEKAMTILEWDRCTSSATVAKVKEEHDEVAIHGVGQAALLRHAGRGDEAKGILLDISAYDRATCKGGNKDDYILASATYELAMLAWDDVCRPERWPTDADEVEEFRRKKTEECYTLLETVAKWETYVLDARFGMRVQTGLDTVRWLSKKKGWTL", "function": "Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.", "AFDB_id": "AF-A4QTI0-F1-model_v4" }, { "swissprot_id": "Q11RK8", "sequence": "MSNSWFQFKQFTVQQDKTAMKVCTDSCVFGATVPVTTSTYTILDIGTGTGLLALMLAQRSNADIDAVELNKDAAQQATDNFFNSPWNERLHVHTCSIQDYFKFTTKQYDLIVCNPPFFSASLKTGNTSKDMALHQSHLLIDELIQVVSFMLKQSGDAYLLISIYEEVNFFQAANRVGLNVKRFQEMYDNETKLIRYVLHLRKDTEHMDHETQNFIIRSADKQYTAQFVEVLRAFYLNL", "function": "Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).", "AFDB_id": "AF-Q11RK8-F1-model_v4" }, { "swissprot_id": "A0A0H3JTK0", "sequence": "MKGAMAWPFLRLYILTLMFFSANAILNVFIPLRGHDLGATNTVIGIVMGAYMLTAMVFRPWAGQIIARVGPIKVLRIILIINAIALIIYGFTGLEGYFVARVMQGVCTAFFSMSLQLGIIDALPEEHRSEGVSLYSLFSTIPNLIGPLVAVGIWNANNISLFAIVIIFIALTTTFFGYRVTFAEQEPDTSDKIEKMPFNAVTVFAQFFKNKELLNSGIIMIVASIVFGAVSTFVPLYTVSLGFANAGIFLTIQAIAVVAARFYLRKYIPSDGMWHPKYMVSVLSLLVIASFVVAFGPQVGAIIFYGSAILIGMTQAMVYPTLTSYLSFVLPKVGRNMLLGLFIACADLGISLGGALMGPISDLVGFKWMYLICGMLVIVIMIMSFLKKPTPRPASSL", "function": "Involved in the export of the metallophore staphylopine.", "AFDB_id": "AF-A0A0H3JTK0-F1-model_v4" }, { "swissprot_id": "Q9P031", "sequence": "MAPVRRSAKWRPGGIEARGEGVSTVGYRNKNVRQKTWRPNHPQAFVGSVREGQGFAFRRKLKIQQSYKKLLRKEKKAQTSLESQFTDRYPDNLKHLYLAEEERHRKQARKVDHPLSEQVHQPLLEEQCSIDEPLFEDQCSFDQPQPEEQCIKTVNSFTIPKKNKKKTSNQKAQEEYEQIQAKRAAKKQEFERRKQEREEAQRQYKKKKMEVFKILNKKTKKGQPNLNVQMEYLLQKIQEKC", "function": "Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.", "AFDB_id": "AF-Q9P031-F1-model_v4" }, { "swissprot_id": "O14908", "sequence": "MPLGLGRRKKAPPLVENEEAEPGRGGLGVGEPGPLGGGGSGGPQMGLPPPPPALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPTAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIHLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGRPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY", "function": "May be involved in G protein-linked signaling.", "AFDB_id": "AF-O14908-F1-model_v4" }, { "swissprot_id": "P61038", "sequence": "MRFFLSFFIIFISSVLFSFGIPNEILNFGSAIAGFSGLVLVYYALLNCGSHKRAAFLYGFFVSFVHLMSSFWLAFFEDFAIFTLGASTLAYFFIAMPFGFLLYHSLQKRENLRPFFFAAIWLLWEFAKSTGFLAYPWGTAPMICFNLKPFIQFVDITGVWGLSFIVPLIAACLGEALQTYAYSANSKAFFKGLTEIKSPLIFTAFLVLIINIYGITILSIEMKPATFLNTVIVQQNTDPWDNSQFEENIKTSQALSRKAIFSANKKPDLIVWSESSLIVPYKDNEDFYGILPYDDPFTRFLADTDTPIIVGSPYIDGKKQYNAAYLLSPEGKILDIYSKIQLVPFAEYIPFIDNPLVVRFFDKLVGFSSGWNPGTEYKVFGIKNSEGKTVNFTVPICFEDAFPAVCLNLHNAGSEVLINITNDSWSKTKSAEYQHFVVAHFRAIELRTTLVRSTNSGYSVVVDPKGKIISDMPLFEAESVYTEVPVYGHKKTFYASYKDWLPIMMFLILIFNIFLEKRRAKTARF", "function": "Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.", "AFDB_id": "AF-P61038-F1-model_v4" }, { "swissprot_id": "A1A008", "sequence": "MEGPEIKAVEAVIDNGSFGKRTLRFETGRLAQQADGAVAAYLDDDSMILSTTTAGSSPKENYDFFPLTVDVEEKMYAAGKIPGSFFRREGRPSSEAILACRIIDRPLRPLFPHTLRNEVQVVETVLAVNPDDAYDVVALNAASASTMISGLPFEGPVSGVRLALIDGQWVAFPRWSERERAVFEIVVAGRVVENGDVAIAMIEAGAGKNAWHLIYDEGQTKPDEEVVAGGLEAAKPFIKVICEAQAELKKIAAKETKEFQLFPEYTEDLYNRIDEIAHADLDEALSIAEKLPRQDRIHEIKEGVKATLAGEFTDMEDAEKDKEIGNAFKELQRQIVRRRILTQDYRIDGRGLRDIRTLSAEVDIVPRVHGSALFQRGETQILGVTTLNMLKMEQQIDALSGPQSKRYMHNYEMPPYSTGETGRVGSPKRREIGHGALAEKALVPVLPSREEFPYAIRQVSEAIGSNGSTSMGSVCASTLSLLAAGVPLKAPVAGIAMGLVSGDVDGQHIYKTLTDILGAEDAFGDMDFKVAGTSEFITALQLDTKLDGIPADILASALQQAKEARTTILEVINECIDGPAEMSPYAPRIITTTVPVDKIGEVIGPKGKMINQIQEDTGAEIAIEDDGTVYISSEGGEAAEKAKEIIDQIANPHVPEAGETYNGKVVKTTSFGAFVNLTPGTDGLLHISQIRNLANGERIDAVEDVLKEGDTVEVVVQGVDDRGKISLAIPGFEDQESSAPRRDRGDRDDRRGGRGRRDDRRRSDDRDDRDYDDRPRRRRSDRDDDRDYDDRPRRRRSDRDDRDYDRDDRRSSRSDRDDRDYDDRPRRRRSDRDDRDYDRDDRRSDRRRGSRRDDRNPRYAADENYDEYRADREERSERPRRRVRRDFDPFED", "function": "Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.", "AFDB_id": "AF-A1A008-F1-model_v4" }, { "swissprot_id": "P24536", "sequence": "MRLGRDMLAPAARLASSRCLGSLARATARKAARSGPDRLLTSRRRFIIDSRRWGRPKTGPNPTDRARPGSKHHIVTDANGTPLAAILTGANVNDVTQLLPLIDAIPPIRGLRGHPLQRPRVVYADRGYDSERHRRALRDRGIEPVIAKRRTEHGSGLGKYRWVVERTHAWLHHFRRLRIRFERRADIHGAFLKLGCCLICWNTLRRADQSL", "function": "Involved in the transposition of the insertion sequence.", "AFDB_id": "AF-P24536-F1-model_v4" }, { "swissprot_id": "Q54JL7", "sequence": "MNQVFFSKIRSLVSADRHRFKSKEMDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEIVSGSHMVEEFVLTFRSIELGPLTKDQANSLSFEIFEHAKEPILNFASSSNSIQIVPINNDNSESNNNNNNNNNNNNNNNNQQQQLYKIIILIQKKVQNDVLIRVYRGDTGKGKGKMKKQIFHLIFNIAFVNLDQCLFGMNEFDHFKSSKKYDPNLQMECRFQNNCTGAPDHSFKIWNIMALQYQRTKSSLNNSITDIKSINEINSTNNNNILASSAPTPLTTTTTTTTTTTTTSLPSSEHSTPQILISSSDANLDLKNCNINCDSSSGGGSNSSRNSNSNSRGGSSNSSSNRSSTSSRSSITTDSIKPSCSSDSICNNSSICNNSCNNNNNNNNNNNNNNNNNNNNNNNNNNNKNSNNNNNESSSNSNDDSDSEASIRKRKNTLWSSGSSIKLKPSPNLSRLSLFNGHRQSFTKKINPNNNEENVDQKTLPILKKETNDPSESDIKNVEIIQD", "function": "Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells.", "AFDB_id": "AF-Q54JL7-F1-model_v4" }, { "swissprot_id": "Q9CDT7", "sequence": "MENLFEKLMEQIKMPPNLRRSSQFEHADIENVEVHTASKLWHFQLIFDEILPIDTYKLLTELTETAFSTIARTEISVSSRNQNIDEQNLNDYYQYALTLPELCDSAFSSIFKKYHLEKEEEKIHLMVEDNPQMDFFVEKYFPILEEKFKSFGFGEVRITPLVDQELTETQAAAHAEKVAARLAAQTAEQAQISEIKKQRSEERESKNTREAKPEFVETALSDGIFFGRKISGQSPITSMSFIAGEGFGVIFEGLVFEAAHREFTGKESGKVNHILELKMADETSTFMISKWGRKDEEIAQFDQIVSTVKAMNEKIIADRTDGEDNFTDSLSDALWLRVQGNIEHDKYKDDLVLTANAVVEIKPKPTIDRVALQIKAVKSDKIQLGREIKNNEPVTPMRSVSEFSTNGPVVFEGYVFKGELREIKSRKTGNISYLLEFEMTDYTSSFYVQKWLRGEEEIQLAKQIKAGLWCRVRGNVQRDNFKNDLVLQLTDLIEIPTQNVREDKSDEKRVEFHAHTNMSQMDAIPSASSLVAQAAKWGHKAIAITDHGGLQSFPEAHSAGKKNGVKIIYGVEANLVEDKIPIVYNETDVDMYESTYVVFDVETTGLSAVHNDLIQIAATKMHKGNPIDEFDEFINPGYRLSEFTTELTGITDDHVKNAKPLYEVLTKFQKFCEGTILVAHNATFDVGFMNMNYSRNGLPIITQPVVDTLEFARNLYPEMKRFGLGQLTKKFQIGLEHHHMANFDAEATGRLLFVFLEELRTRNTGWTSLLELNDKLVSEDSYKKVRPKHVTLYAKTQEGLKNLFKIVSFGNVKYYAGLPRVPRSVLEANREGLLVGSACEIGEVFDAAINKTFEETLEIAKFYDFIEVFPPALYRSLVVGGSFKSEKELEQTLKDLIKIGKTLGKPVLATGNLHYLNPEDAIYREIIVRSLGLGAEINWTQGHGEHAKPLPLPEAHFRTTDEMLEAFSFLDEKTAREIVIDNTQKMADEFDVLTPVRDDLYTPKMVFDGGETSEERIVRLTYEKAHEWYGNPLPDIIDARLEKELRSILGNGFSVVYIISQELVKRSNDRGYIVGSRGSVGSSLVATMIGITEVNPLAPHYRCPECQYFECYDDGSFGSGYDMPDKNCPKCDHKLIKDGHDIPFETFLGFKGDKVPDIDLNFSGDDQPLAHLDVRDIFGEDYAFRAGTIGTVAEKTAFGFVKGYERDYDQFYGNAEIDRLAAGSTGVKRTTGQHPGGIIVIPNYMDVYDFSPVQFPADDVNAEWQTTHFDFHAIHDNILKLDILGHDDPTMIRKLQSLSGIVPQDIPMDDPGVMKLFTGTESLGLTEEQLGVKLGTLGIPEMGTFTSMNMIAEAKPKNFADLLQISGLSHGTDVWSGNAQDLIRSGIADLSSVIGCRDDIMVYLIHKGLENGLAFTIMERVRKGMWNKIPAEEREKYVEAMREHDVPEWYIESCSKIKYMFPKAHAAAYIMMALRVAYFKVHHPILYYCAWFSIRATAFDIGVMGAGLEAVKAKMKEIKDKGFDATNVETNLYTTLELCNEMLERGFTFGKIDLYRSEATEFVIDGDTLIPPFVTMDGLGENVAKQIVAARAEGEFLSKMELRKRGGVSQTIIENMTNMGVLEGMPDDNQLSLFDDFF", "function": "Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.", "AFDB_id": "AF-Q9CDT7-F1-model_v4" }, { "swissprot_id": "Q59S52", "sequence": "MSFDINWNQLTIDDTINQSIKEFLDQQFKNISLPSFISNLAVTDFNLGEIPPEVTIRHIGDPFEEFYEDENNLGVMNEANNDSKDEHLKNHGDGINKDSGYNSQNLDDEDEDDEDDDEDDEDEEEEDEDDYDDHDLGTINEGISLLNFNENSTTPSANSFAGSAAPPLPPPLNPSRDSFHSILHPYGVNSIIGATGAGSETPTNILNQNYLSSRVLPKISVKQKQPHHDDNDIQLIVEINYKGDMHINLLVNLLVNYPSPNFISLPIKLHITDIVIHSIATIAYLKKSVFLSFLCDVDDTFPDFDSNVQTPTSTTGGNFVDYYSNDATINKERIDIVKKIKIESEIGEVENNILRNVGKVEKFLVEQLRNILRDEIAWPSWICIDMNDDDDEEEEEEESEDNDGGNSDLNDNDGKHGDGRTDETEAGE", "function": "Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.", "AFDB_id": "AF-Q59S52-F1-model_v4" }, { "swissprot_id": "Q9LFS2", "sequence": "MVAFRFVYIPLPFFFFFFFFFVFFSGVSQLQDQTATKKSVRILSKILIGDDGRVYACSDNDFFSFESNGSIAWSVHMNFKCNTDFAPVYSGFNQMLLLAENRILRVIFPRNGTKSEPELFFDPGETILGFAVSVSSSSVYITVKNHGLYAYNMFRQQLWIAEPKIERFGYRLGCRKDFDNCTFNSRPVIDSCEGSIYISNNEGELYSLSLRGTYYQWIQDFSLVDRFFTVTPGNNGLVYVVFPIKSLVFALDSFSGDILWQKTIGPLAETSASDPVIDSNSWASIGSLDGTLYSFSRTGDLYKIPKNAETDSVIQIEPLLDCSGYAVYVSQTKFEGMIDRVIEDYTYVSAKKPETAVFSLVVPETRSIYWSQSYSDQIPGLLLDEDLQHFVLDERIALAFVAASSSGNPFRCRSKHEKLSSSCSFAEPEHLDIYIGNERAIIWFLLFEFVIMVLFAALVRFCFIFWKKKKLQDRPFSTFLDKRRLLHRKSREIDKTITRLQNESTANESAVDKIGDLIQKRENVKRKLSSTYSLGRDIDESKSKLKDYVLPLYGGSSRSFSYRNRENESITIFQTPSDESSSEESYRDEHYDDVADDEHDEDDLDRKQKGKLLAHSEGSSNDGDGIASSRRSIYLKHIFDD", "function": "Required for micropylar pollen tube guidance. Plays a role during early embryo patterning.", "AFDB_id": "AF-Q9LFS2-F1-model_v4" }, { "swissprot_id": "Q9UTC6", "sequence": "MSVFRRSVQCVGVLPSILAQRSSLLARPANLQFLKTNSSKFVPQVTANVSRRMYHKNVLDHYNNPRNVGTLPKGDPDVGIGLVGAPACGDVMRLAIRVNKDGVIEDVKFKTFGCGSAIASSSYVTTMVKGMTLEEASKIKNTQIAKELCLPPVKLHCSMLAEDAIKSAVKHYRSKQLTPVGTTAGAIESATA", "function": "Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein isu1. In a second step, the cluster is released from isu1, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on isu1 depends on the function of the cysteine desulfurase complex nfs1-isd11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH.", "AFDB_id": "AF-Q9UTC6-F1-model_v4" }, { "swissprot_id": "Q06244", "sequence": "MSLKKQIPIIFENTHYFIVNKPPGIPSQPPDCRTWGRTHPNLDPTPLLERFKAIYYSHREVELCRTVHRLDHCVTGGMLIAKTKDGSVKFSRFLQKGGNNGYKLQRKYVAIVESSGRFNKPNNYEIKYGPKYNFLISHGGREITKFKEVDENCIVLQLVTGKKHQIRNHVSQILNQPILNDKRHGSTVNFPELFNDQIALHSACIITKIGLQTKTHLIPMEHNNTGQLWSRKYVNEEGEFTLPIKEVLLENWDQ", "function": "Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.", "AFDB_id": "AF-Q06244-F1-model_v4" }, { "swissprot_id": "Q2J7L5", "sequence": "MAVRDGGGSAPVGSQEQAVDRVRETVARSRRYGAVAPETVRRLAERALVASRGDEPEAVKRTKRSLHEIYGAYLPERAPGYPGLLRDIGAAVGGGDPDAVAAAVSRAMRVHASTRERLPYLREFYAAVFGAVPTPAVVQDLACGLNPLAFGSMGLPAQTTYLASDIDSQQMEFLDRALDLLEVEHRVEVVDLVSGAVPAQHADVTLVLKTLPLLERQRAGAGWELVDALRSPFVVVSFPTRSLGQRSKGMFQTYSAAFEAQAAERGWTFDQAEIANELIYIVRR", "function": "Specifically methylates the N(7) position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides, including gentamicin and kanamycin.", "AFDB_id": "AF-Q2J7L5-F1-model_v4" }, { "swissprot_id": "Q62656", "sequence": "MRILQSFLACVQLLCVCRLDWAYGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPICNSPKQSPINIDEDLTQVNVNLKKLKFQGWEKPSLENTFIHNTGKTVEINLTNDYYLSGGLSEKVFKASKMTFHWGKCNVSSEGSEHSLEGQKFPLEMQIYCFDADRFSSFEETVKGKGRLRALSILFEIGVEENLDYKAIIDGTESVSRFGKQAALDPFILQNLLPNSTDKYYIYNGSLTSPPCTDTVEWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLITWERPRVVYDTMIEKFAVLYQPLEGNDQTKHEFLTDGYQDLGAILNNLIPNMSYVLQIVAICSNGLYGKYSDQLIVDMPTEDAELDLFPELIGTEEIIKEENYGKGNEEDTGLNPGRDSATNQIRKKEPQVSTTTHYNHMGTKYNEAKTNRSPTRGSEFSGKSDVLNTSLNPTSQQVAEFNPEREMSLPSQIGTNLPPHSVEGTSASLNSGSKTLLVFPQMNLSGTAESLNMVSITEYKEVSADLSEEENLLTDFKLDSGADDSSGSSPASSTVPFSTDNLSHGYTSSSDTPEAVTYDVLRPESTRNALEDSAPSGSEESLKDPSLEGSVWFPGSTDLTTQSETGSGREGFLQVNSTDFQVDESRETTETFSPDATASRGPSVTDMEMPHYSTFAYPPTEVTSHAFTPSSRPLDLAPTSNILHSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQTLNTTPAASSSDSALHATPVFPSVGVSFDSILSSYDDAPLLPFSSASFSSDLFHHLHTVSQTLPQVTSAAERDELSLHASLLVAGGDLLLEPSLVQYSDVMSHQVTIHAASDTLEFGSESAVLYKTSMVSQIESPSSDVVMHAYSSGPETSYAIEGSHHVLTVSSSSAIPVHDSVGVADQGSLLINPSHISLPESSFITPTASLLQLPPALSGDGEWSGASSDSELLLPDTDGLRTLNMSSPVSVADFTYTTSVSGDDIKPLSKGEMMYGNETELKMSSFSDMAYPSKSTVVPKMSDIVNKWSESLKETSVSVSSINSVFTESLVYPITKVFDQEISRVPEIIFPVKPTHTASQASGDTWLKPGLSTNSEPALSDTASSEVSHPSTQPLLYEAASPFNTEALLQPSFPASDVDTLLKTALPSGPRDPVLTETPMVEQSSSSVSLPLASESASSKSTLHFTSVPVLNMSPSDVHPTSLQRLTVPHSREEYFEQGLLKSKSPQQVLPSLHSHDEFFQTAHLDISQAYPPKGRHAFATPILSINEPQNTLINRLVYSEDIFMHPEISITDKALTGLPTTVSDVLIATDHSVPLGSGPISMTTVSPNRDDSVTTTKLLLPSKATSKPTHSARSDADLVGGGEDGDDYDDDDYDDIDSDRFPVNKCMSCSPYRESQEKVMNDSDTQESSLVDQSDPISHLLSENTEEENGGTGVTRVDKSPDKSPPPSMLPQKHNDGREDRDIQMGSAVLPHTPGSKAWAVLTSDEESGSGQGTSDSLNDNETSTDFSFPDVNEKDADGVLEADDTGIAPGSPRSSTPSVTSGHSGVSNSSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKHVADLHASNGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDGSEEYGSFLVNQKNVQVLAYYTVRNFTLRNTKIKKGSQKGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAFVRKTAQAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSYVNTLLIPGPSGKTKLEKQFQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMSEEHKCLSNEEKLIVQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISIIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSMDVYQVAKMINLMRPGVFTDIEQYQFLYKVVLSLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV", "function": "Isoform 3 (phosphacan), previously designated 3F8 chondroitin sulfate proteoglycan or 3H1 keratan sulfate proteoglycan depending on the glycosylation status, is a soluble nervous tissue-specific proteoglycan. It is synthesized by glia and binds to neurons and to the neural cell adhesion molecules tenascin, N-CAM or NG-CAM but not to laminin and fibronectin. Phosphacan acts as a potent inhibitor of cell adhesion and neurite outgrowth.", "AFDB_id": "AF-Q62656-F1-model_v4" }, { "swissprot_id": "B8ICE5", "sequence": "MPAQTSRARPVEEMTAAQAREAHESLSAEIAEHDRRYHGEDAPIISDAEYDALRRRLEAIEERFPELAGTGAASVSVGAKASDKFAKVRHAVPMLSLGNAFAEEEITEFVERVRRFLGLPASEPLAFTAEPKIDGLSLSLRYEGGRLVTAATRGDGEVGEDVTANVRTIREIPHELAGDDVPEICEVRGEVYLSHADFAAINARQEEAGRPLFANPRNAAAGSLRQLDPGITASRPLRFFAYAAGEMSSWPAETQSGLIGAFRRFGLPVNPRTKRCTSVAEMLAHYRAIETERAELGYDIDGVVYKVDEFALQRRLGFVARAPRWALAHKFPAQRAVTVIEAIEINVGRTGSLNPLARLKPVTVGGVVVSNATLHNEDYIRGIDADGNTIRSGINIWDGFRLREDVDLRQGSDVRVGDTVVVLRAGDVIPKVADVVLERRPADAVPYAFPETCPACGSHAVRAYNPRTGKLDSVRRCTGGLICPAQGQERLRHFVSRNAFDIEGFGETYIATLFEAGLVRQPADLFRLDFEPLKAAIVARRQALSAERALAAGKTPEAKKAKPKANEEDKAIHNLLAAVEARRTIPLNRFIFALGIEQVGEATAKALAKHFPDMPALMEGVRAAAACRPGPDWIELASLPRVGPTTRERLLAAAEAGETDLLADGAVTRLTSAQKEALLAAYGDRDGLRNAVERALRQKPGDAYRHLADDSEIGAVTTASLIEFFSEAHNVEAVEALLREVRTERAGTPAAAAVFSGQTVVFTGSLERMTRSEAKATAERLGAKVSGSVSAKTDLVVAGPGAGSKLKDAEKHGVRVISEAEWLAMVEAA", "function": "DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.", "AFDB_id": "AF-B8ICE5-F1-model_v4" }, { "swissprot_id": "P05103", "sequence": "MAFAPSVAHKPVAAAVCPVMAATEALATEGGLEARGAIFTRSEVVDFILDLAGYTEDQPLHEKRLLEPSFGGGDFLLPIIQRLLSAWRAARPNGTEVDDLGDAIRAVELHHDTFRSTYAAVVALLKREGLSANAATALADRWLSQGDFLLAPLEGQFDFVVGNPPYVRPELIPAPLLAEYRSRYQTMYDRADIYIPFIERSLTALSAGGNLGFICADRWMKNRYGGPLRSLVAERFHLKVYVDMVDTPAFHSDVIAYPAITIISREGGGATRIAHRPSIDRATLTTLAGLLSAPTLPKDAGPVRELARVTNGAEPWLLESSDQMALIRRLEGAFPLLEEAGCKVGIGVATGADKAFIGDFESLDVEPDRKLPLVTTKDIMTGEVQWRGQGVINPFAESGGLVDLGEYPRLRRYLEARRDVIAGRHCAKKAPANWYRTIDRITPALAARPKLLIPDIKGESHIVFEGGELYPSHNLYYVTSDDWDLRALQAVLLSAVSRLFVATYSTKMRGGFLRFQAQYLRRIRIPRWADVPEPLRRELAEAAIKRDVQACNRAVFRLYGLSHEERSALGGNGE", "function": "A gamma subtype methylase, recognizes the double-stranded sequence 5'-CTCGAG-3', methylates A-5 on both strands, and protects the DNA from cleavage by the PaeR7I endonuclease.", "AFDB_id": "AF-P05103-F1-model_v4" }, { "swissprot_id": "Q9CWU5", "sequence": "MASLKRFQTLVPLDHKQGTLFEIIGEPKLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGEHIPHLESMLHTLIHVNVWGPERRAEIWIFGPPPFRRDVDRMLTDLAHYCRMKLMEIEALEAGVERRRMAAHKAATQPAPVKVREAAPRPASVKVPETATQPAPVKVREAAPQPAPVQEVREAAPQQASVQEEVREAATEQAPVQEVREAATEQAPVQEVSEAATEQAPVQEVNEAATEQASVQAVREAATRPAPGKVRKAATQPAPVQVCQEATQLAPVKVREAATQPASGKVREAATQLAPVKVRKAATQLAPVKVHEAATQPAPGKVSDAATQSASVQVREAATQLSPVEATDTSQLAQVKADEAFAQHTSGEAHQVANGQSPIEVCETATGQHSLDVSRALSQKCPEVFEWETQSCLDGSYVIVQPPRDAWESFIIL", "function": "As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation. Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific. Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks. As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for maintenance of euploidy during cleavage-stage embryogenesis. Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus. May regulate normal development of learning, memory and anxiety. Capable of binding RNA.", "AFDB_id": "AF-Q9CWU5-F1-model_v4" }, { "swissprot_id": "B5RSP9", "sequence": "MSSDEASSEALAQEDIKQITLRIKLPACISNEEDLEVPSLLSETLADIRETLNLSAATQNLTNFNVFYQDINLSENFDDLVPLNDILTELGVGEIDSLNLVLKEKPYNLAAIYDHLNKFREVIGLHFLDKYSSEVGVLSGVSKFGDIDLQDVKETEPETQDDKDKETDETKSTKEDSNQTEEKKSEIVFTAEEKQQIGKITDELISGNTPSLVEFGTFDNISGSIKTPIKSLTVSQWSPVPSFQKLKGDLLYITLQTLENETLNITCHLSGFFVNKSSTINFNPAIKMNENGKVHKDYLLINLVDSLSPSFSKTIQENELVLSRSSKHPESFLIPSNSLMSSPWIVNPSKFANQPDASRSQLPLISNGVDGSGFVKEWNEDFQAIRELPNSTINERILREKLLMKSLHEFNKVATETAMNVIKGNLTPLNPNEPKDYHIYLRNGIFYSLGVNATGAFDCTGGNEAARYTSSKDLAAIKLLNRIDAKGIYNLVTCIVDYMGQRVICQAPVPGILDSSHEDENEEEPTDKVCYGLSTDGSKIFSDSSFENVLKPIAEAFHLKPHPVTLLDNVKSQGDLITSKDIKGVKGTDERKYIIDLYRATPLDIEFIESNWDESKETSYPHRETALRHEAVEEWWKRKVSVLFKAETERLEKEGKLESKDGEKPQIVLPSDQITINTDAFTTIDESSDDQNEVREVSKFIKEHLIEEFLEENSKQISPFDGNHLTSMLHKQGINLRYLGHIAEQACVRKDEHLKKITEARKVNEEEISKRKEESEKKATEGKDQDKEEEKANDNEKNKEDDKEEVSNGEFEPIVANFDSLYRISVQEMVARSVKHLLRKISADIPVYLIPAFVSHFHNCLLGSEINSSPECIIDETLKGFYNATELEFTKLNSNKVIALVANEVLIRFRYELPTDWISTLIRPFQLFREIAIKYGIQWKSQEYAFTNEEFEKVKDKLAVETQVFEAKTSKHKKNKKQQSQLITKSVDRTTIFVTDDIVNFVPIVKDSTYRSSLVDEIFETARAQIFKGETETGINLLNNLLSVYEQIYGRVHPETSKFYGLLSQYYAELGLKSEACNIARKACILAERTTGFDSYESITAYINSAFFESTNDDYINALNLYNKAINDWTLVYGDGHPSSVNTYANLAELLSEHKLFQQANKLFEKAISISTKLNGEESQICGMLRYRYGGTLLGGGDFKSALDQFKSANDIFTKFIGPDDQLSKKSLSFVTNISTYLAYNEHQKSEQKKALAQQASASNGKVKAKSAVEQQLKSSKKGKKNDATQPNPEIASKSVDDILQYIEGKNPKKQLKKKSNNKKSKK", "function": "mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.", "AFDB_id": "AF-B5RSP9-F1-model_v4" }, { "swissprot_id": "P51534", "sequence": "MPLCEKGNDPIDSSTIDSLCAAFDKTLKSTPDVQKYNDAINTIFQLRQKSESGKMPADLTNSEALKDRQKIEEILTRSYQDHSESRVHLSKLIQNDIPFALNLFEILSRSSIHVFVGCFSNKDATIALLNELQIRIHYGEDTHVTYLLSIILQLLNKFKYNFKEVRFLVKELILRISEDEVKSMMLIIFAELQSSFQKDFDKAVVDFMSSLIVEAEIDVGNDPLSIIVKTLSELYPSLTTLCSEIFLTKGLSKLFKKRVFEEQDLQFTKELLRLLSSACIDETMRTYITENYLQLLERSLNVEDVQIYSALVLVKTWSFTKLTCINLKQLSEIFINAISRRIMPKIENVNESAVKLEEVPKVEMSVEALAYLSLKASVKIMIRSNESFTEILLTMIKSQKMTHCLYGLLVIMANLSTLPEESNGSSQSINDLKNYADLKGPGADKVGAEKESKEDILLFNEKYILRTELISFLKREMHNLSPNCKQQVVRVIYNITRSKNFIPQCISQGGTTIILEYLANKQDIGEPIRILGCRALTRMLIFTNPGLIFKKYSALNAIPFLFELLPRSTPVDDNPLHNDEQIKLTDNYEALLALTNLASSETSDGEEVCKHIVSTKVYWSTIENLMLDENVPLQRSTLELISNMMSHPLTIAAKFFNLENPQSLRNFNILVKLLQLSDVESQRAVAAIFANIATTIPLIAKELLTKKELIENAIQVFADQIDDIELRQRLLMLFFGLFEVIPDNGTNEVYPLLQENQKLKDALNMSLKRGDSGPEFSAAIPVILAKIKV", "function": "Required for mother cell-specific ho expression. Might be required for the transport of factors (such as ASH1) that promote HO repression from the mother cell into its bud.", "AFDB_id": "AF-P51534-F1-model_v4" }, { "swissprot_id": "Q28FB9", "sequence": "MGDKMDMSLDDIIKLNRSQRPAGRGRGGGRGARGGSARGGAGGRIGGGRGGGGGGAAGGGGPMRSRPVLTRGGRNRPAPYSRPKQLPDKWQHDLFDSGFGTGAGMETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIEAQRRPIQSQSRGGGITRPRGGAIGFSGANRRGGRGGNRGRGRGAGRNPKQQLSAEELDAQLDAYNARMDTS", "function": "Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.", "AFDB_id": "AF-Q28FB9-F1-model_v4" }, { "swissprot_id": "P46578", "sequence": "MFRKLGSSGSLWKPKNPHSLEYLKYLQGVLTKNEKVTENNKKILVEALRAIAEILIWGDQNDASVFDFFLERQMLLYFLKIMEQGNTPLNVQLLQTLNILFENIRHETSLYFLLSNNHVNSIISHKFDLQNDEIMAYYISFLKTLSFKLNPATIHFFFNETTEEFPLLVEVLKLYNWNESMVRIAVRNILLNIVRVQDDSMIIFAIKHTKEYLSELIDSLVGLSLEMDTFVRSAENVLANRERLRGKVDDLIDLIHYIGELLDVEAVAESLSILVTTRYLSPLLLSSISPRRDNHSLLLTPISALFFFSEFLLIVRHHETIYTFLSSFLFDTQNTLTTHWIRHNEKYCLEPITLSSPTGEYVNEDHVFFDFLLEAFDSSQADDSKAFYGLMLIYSMFQNNADVGELLSAANFPVLKESTTTSLAQQNLARLRIASTSSISKRTRAITEIGVEATEEDEIFHDVPEEQTLEDLVDDVLVDTENSAISDPEPKNVESESRSRFQSAVDELPPPSTSGCDGRLFDALSSIIKAVGTDDNRIRPITLELACLVIRQILMTVDDEKVHTSLTKLCFEVRLKLLSSIGQYVNGENLFLEWFEDEYAEFEVNHVNFDIIGHEMLLPPAATPLSNLLLHKRLPSGFEERIRTQIVFYLHIRKLERDLTGEGDTELPVRVLNSDQEPVAIGDCINLHNSDLLSCTVVPQQLCSLGKPGDRLARFLVTDRLQLILVEPDSRKAGWAIVRFVGLLQDTTINGDSTDSKVLHVVVEGQPSRIKKRHPVLTAKFIFDDHIRCMAAKQRLTKGRQTARGLKLQAICSALGVPRIDPATMTSSPRMNPFRIVKGCAPGSVRKTVSTSSSSSQGRPGHYSANLRSASRNAGMIPDDPTQPSSSSERRS", "function": "Regulator of mitophagy.", "AFDB_id": "AF-P46578-F1-model_v4" }, { "swissprot_id": "Q9UKF5", "sequence": "MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS", "function": "May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.", "AFDB_id": "AF-Q9UKF5-F1-model_v4" }, { "swissprot_id": "B8X8Z0", "sequence": "MKFYTISSKYIEYLKEFDDKVPNSEDPTYQNPKAFIGIVLEIQGHKYLAPLTSPKKWHNNVKESSLSCFKLHENGVPENQLGLINLKFMIPIIEAEVSLLDLGNMPNTPYKRMLYKQLQFIRANSDKIASKSDTLRNLVLQGKMQGTCNFSLLEEKYRDFGKEAEDTEEGE", "function": "The TA system protects P.atrosepticum strain 1043 against phage phiM1 and phiA2, E.coli against some but not all coliphages and S.marcescens against some bacteriophages, causing an abortive infection (Abi phenotype). Also protects P.atrosepticum strain 1043 against phage phiTE; phage that escape Abi and grow in this bacterium have evolved a pseudo-ToxI RNA by expanding a pre-existing sequence similar to the bona fide ToxI repeats.", "AFDB_id": "AF-B8X8Z0-F1-model_v4" }, { "swissprot_id": "Q5XHY3", "sequence": "MCPPVSVRHGARGMSCLYGAWLYQLVHGEQMKMCFACFKAAFLLNKFYLEMGYWEQEELSEEEEEEEVWDAEPMEHLSESESLESDSKQDAGSEQDAGSEPNTRSEQDAWQGVGSLYVPQSVSEYGGPGALVPTPSWTQWVVFSISVPTELLPQEAVPLDLGPEDVEWTQALPWRLDVLFPCSHRLIPPLSWWDILDVMPSLGQPVLLELRSLWPLDQSVAQTWLQDQKFVLLLDSIHFMCHLLSMHVCWAVRTQVQHWQVLLNPGEMWVAHLKRVLFRPRGLYPWSLSILKSSDLGMELVPAAFYLRKKGFWVGSFLPWNSSIPETWSWDPGERLFITDATICATNYHFARSFFP", "function": "Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis. Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization.", "AFDB_id": "AF-Q5XHY3-F1-model_v4" }, { "swissprot_id": "Q10414", "sequence": "MIFYDKLKPADVLVIGSADGRVIEAIEYIADLHKQHGFKFAICLGNLFSHKRTTSADVVKLKNEKVKVPIPVYFGVGTAGLPESIISHMAMYGPEVAPNLFCMGICGFMKTFYKFTIAQLGGSYNEEKYYQPPEKFEQSLNEKCFHRSDVQKLSKRCDILFSSEWPEDVQENSTLPERKLPKGCMPLAALAANCMPQYFFVPGPVYYEREPYKNSAAINVNTGTVTHFVALAPFKNSKNEKFSYAFTLYPLTTEYMQPAPPNCTASPFEHRPIPLKRASEDQIIPQQTNKFHKSKSSTALFKSKKDSSSSLNKMHKSESHSALNNLHKSESGTSLNNRRSKVGPGSCFFCLSNPNVALHLIVAIGNEAYMALPKGPLTTTASNTPALASSGHVLIIPIAHASALSTLSDTSYEKTLNEMNRFRKAVTDMYNACDSDALVYEISRANGVHLHWQMIPIPKISSHRIESVFLEMAKEAGYDFEERDVEPHELNYFRVFLPSGKILIHRLQLRERFDLQFGRRAAAKILGLEDRVDWRKCVQTEDEEKAESEAFKMCFKPYDFT", "function": "Has a role in meiosis.", "AFDB_id": "AF-Q10414-F1-model_v4" }, { "swissprot_id": "Q4R6N0", "sequence": "MCRVMKASFSRKVKLELCLLSDCALLSSSSAPTNELSGTNLEAHINESPDPNALVGVIIERSPSDSTQTNEFKGATKETLTIETPHSSECKGAGLLSPVSKSMLERLSKFEVEDAENVASYDTKIKKIVRSIVSSFAFGIFGVFLVLLDVTLLLADLIFNDSKLYIPLVYRSISLAIALFFLMDVLLRVFVEGRQHYFSDLLNVLDTAIIVTPLLVDVVYIFFDIKFLRNIPRWIHLVRLLRLIILIRIFHLIHQKRELEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHPNHYRVYNLCSERAYDPKYFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDPANIVAIHCKGGKGRTGTMICAFLIASEIFLTAEESLYYFGERRTDKTNSSKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGVGTGGVCDLKVRIVMEKKVVFSSTSLGNCSILHDIETDRVLIDVFSGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQSNRHILHSFRLVFT", "function": "Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.", "AFDB_id": "AF-Q4R6N0-F1-model_v4" }, { "swissprot_id": "Q8RWB8", "sequence": "MFFSGDPSTRKRVDLGGRSTKERDARKLLEQTRMERNRRLLQKQQNSAALKIQKFFRGRRSMAIERSKVRHDFCETYGNNCQNVDRHCFEPGSSFLRQFLFFFKAQNSGDFVILVETCRLLQSFVDSSGDIVSLFSGLDYSSEHNLVDFRVKKLAFTCIEAIHQNRNRLRDQLLVTPEEASISTAILMEAVSLLLDPKLPWVCKIVSYLQKRKVFKLVREMVTTAKESPRGKTMTGNILSLERVLILIVPHIGREPCCCTVVDPRWSFSSMILTIPLIWKLFPNLKVVFANPSLSQHYIHQMASCIQKDTCVLPMETSPEFPGYACLLGNTLDTANVVLSQPECSLDMAIDIALVATFFLETLPPVKSSEGESRQGSSDEDDMLIDDVPGLVLNKALEQQITNAIDSRFLLQLTNVLFRQVSLGMQSYDEDKEALAIGTASSFLYAAFNTLPLERIMTILAYRTELVAVLWNYMKRCHENQKWSSMPKLLAYLPGDAPGWLLPLVVFCPVYKHMLMIVDNEEFYEREKPLSLQDIRLLIIILKQALWQLLWVNPLTQPNTGKSVSNDLSKKNPIELIQNRMGIVVSELLSQLQDWNNRKQFTSSSDFQADSVNEYFISQAIMEGTRANYILMQAPFLIPFTSRVKIFTTQLATARQSHGSQGIFARNRFRIRRDHILEDAYNQMSALSEDDLRSSIRVTFVNELGVEEAGIDGGGIFKDFMEKITRAAFDVQYGLFKETADHMLYPNPGSGMIHEQHLQFFHFLGSLLAKAMFEGILVDIPFATFFLSKLKQKYNYLNDLPSLDPELYRHLIFLKRYKGDISDLELYFVILNNEYGERTEEELLPGGQDMRVTNENVITFIHLVSNHRLNFQIRQQSSHFLRGFQQLIPKEWIDMFNEHELQVLISGSVDSLDIDDLRNNTNYAGGYHAGHYVIDMFWEVMKSFSTENQKKFLKFVTGCSRGPLLGFKYLEPAFCIQRAAGSASNESVDRLPTSATCMNLLKLPPYQSKELLETKLMYAISAEAGFDLS", "function": "Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q8RWB8-F1-model_v4" }, { "swissprot_id": "Q53684", "sequence": "MRTRITLALAVLLLLLAGCSPGAPADGPVTLRFQSLAWQPDSVAATKELVGEWNATHPDVKVEYIQGSWDSVHDQLLTSFEGGEAPDVIHDASDDLADFAYGGYLADLSGLLPARLASDIPRGSWETATFGRGVYGVPFLQEPRVLIADADRLRAAKVRIPTPGHPWSWPEFRQVAKKLTGPGRYGVAWPLKEPVSATLNLSLSAGGRLFHRGADDKVTVRFEAGDEVVARTIHDQVAVDREHAPASTLGSGGADTLPGLFGGRYAMVPLGFSYRQQIVRQAPEDFHWQVLPAPAGAGGLTQGVSPQTLSVSADCPHKKEAVAFIDFLLRPRNMVRLALGDWMLPTGTQALKDPALHTARHGWATGTALAARLRPAPAQSVRGYPEWKDKVATPAYQRYYSGASTLADVRHAWSGTATWCWPATSADPPPGVPRAGKRNIRDATSRLPSTP", "function": "May participate in oleandomycin glycosylation and secretion during antibiotic production.", "AFDB_id": "AF-Q53684-F1-model_v4" }, { "swissprot_id": "Q7SI68", "sequence": "MAPSKVVIYAMRRELRLSDNPIFHHLSNPESKHGFSHLLPVYVFPAQQIDLSGFVPKGSENPHPAPKSAVGGYARCGPYRAKFLAESVWDLKTSLQSIGSDLLVRAGPYKDVIQSLVEGLKAKECQVGAVWMTSHEGSEEKSEEKTVASFCAKSGIDFKLWDDEKYLIHDRDTGITHLNDLPDVFTTYRKQIEPLREKARKTLPVPEKGALPAYPDIDMIPSQQPPFNIPGTCEELVDAVVRPVKNFLKDLPDFPEKAESSHPFRGGETSAHKRIDHLVLSGGMKSYKDSRNGLLGPDFSTKLSAYLAQGCVTARQIHHALVAYEDGTGTKYKGADGFGEGDNQGTETVRMELLWRDYMRLCHQKYGDKLFRVEGFNGKHTDYEGEDKKYGWRTANTSIALPGQEPTPEKVSEILARFNAGTTGMGLIDASQRELIHTGYTSNRTRQNVASFLAKHLEIDWRYGAEWYEMLLVDYDVSSNWANWQYVAGVGNDPRGAARIFNPVKQAFDYDKDGTYVRTWVPEVAKFENLENVFQAWTASKEDLKTAGLEGNIMVTDPVKPIKFNLDHKPSKVKKRPFFRKRGTKTRDAQGSAESPGSSDSHSGSGGSPDGSGGGNIPSESNCAAAGSGQAQQTHQGSGRSQSSSNHGGRSHSHQHNQQNYHHSHRGNDYTRGGGGGRGGRGGRGGGGGGYSASQGYYGIGGGYRGGGRGRGGGGGFRGRYAPTGGLGGHHHSEQQVASQFQTDA", "function": "May have a photoreceptor function.", "AFDB_id": "AF-Q7SI68-F1-model_v4" }, { "swissprot_id": "Q8VC42", "sequence": "MGGEDYYLELCERPVQFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGPDDRNPISFRMDDRGEVKCIKFSLENKILAVQRTAKAVDFCNFIPDNSQLEYTQECKTKNANILGFCWTSSTEIVFITDQGIEFYQVMPEKRSLKLLKSHNINVNWYTYCPESAVILLSTTVLENVLQPFHFRAGTMSKLPKFEIELPAAPKSTKLSLSERDIAMATIYGQLYILFLRHHSRTSNSTGAEVVLYHLPREGACKKMHILKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIRLRGEFDGTVTFHHPVLPARSIQPYEIPLAGPAAVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLQPIVNLLPDKGRLMDFLLQRKECKAVVLSVCSQMLSESDRATLPVIATVFDKLNHEYKKYLDADQSYTMAVEAGQSRSNPPLKRPVRTQAVVDQSDVYTQVLSPFVENKEMPHKFVIAVLMEYIRSLNQFQIPVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAARQTDDVMLFYTIFRFFEQRNQRLRGNPNFTPGEHCEEHVAFFKQVFGEQALMRPTTF", "function": "Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization.", "AFDB_id": "AF-Q8VC42-F1-model_v4" }, { "swissprot_id": "Q58718", "sequence": "MSMILKEIRMNNFKSHVNSRIKFEKGIVAIIGENGSGKSSIFEAVFFALFGAGSNFNYDTIITKGKKSVYVELDFEVNGNNYKIIREYDSGRGGAKLYKNGKPYATTISAVNKAVNEILGVDRNMFLNSIYIKQGEIAKFLSLKPSEKLETVAKLLGIDEFEKCYQKMGEIVKEYEKRLERIEGELNYKENYEKELKNKMSQLEEKNKKLMEINDKLNKIKKEFEDIEKLFNEWENKKLLYEKFINKLEERKRALELKNQELKILEYDLNTVVEARETLNRHKDEYEKYKSLVDEIRKIESRLRELKSHYEDYLKLTKQLEIIKGDIEKLKEFINKSKYRDDIDNLDTLLNKIKDEIERVETIKDLLEELKNLNEEIEKIEKYKRICEECKEYYEKYLELEEKAVEYNKLTLEYITLLQEKKSIEKNINDLETRINKLLEETKNIDIESIENSLKEIEEKKKVLENLQKEKIELNKKLGEINSEIKRLKKILDELKEVEGKCPLCKTPIDENKKMELINQHKTQLNNKYTELEEINKKIREIEKDIEKLKKEIDKEENLKTLKTLYLEKQSQIEELELKLKNYKEQLDEINKKISNYVINGKPVDEILEDIKSQLNKFKNFYNQYLSAVSYLNSVDEEGIRNRIKEIENIVSGWNKEKCREELNKLREDEREINRLKDKLNELKNKEKELIEIENRRSLKFDKYKEYLGLTEKLEELKNIKDGLEEIYNICNSKILAIDNIKRKYNKEDIEIYLNNKILEVNKEINDIEERISYINQKLDEINYNEEEHKKIKELYENKRQELDNVREQKTEIETGIEYLKKDVESLKARLKEMSNLEKEKEKLTKFVEYLDKVRRIFGRNGFQAYLREKYVPLIQKYLNEAFSEFDLPYSFVELTKDFEVRVHAPNGVLTIDNLSGGEQIAVALSLRLAIANALIGNRVECIILDEPTVYLDENRRAKLAEIFRKVKSIPQMIIITHHRELEDVADVIINVKKDGNVSKVKING", "function": "Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.", "AFDB_id": "AF-Q58718-F1-model_v4" }, { "swissprot_id": "Q9RS57", "sequence": "MRAVVSLAVVFVLSYLLGSLVAGVLYSRGRGEDIRGRDLPGGSGTYRQYGKGAAAAVTLADILKGAAAVGLALWLAPQALPLATALATFGVVFGHCYPVWFGFRGGGGIAPFLGAMLVVAPWTLLATVTFALALIPLYRATLQPRLRLNAIPFATVVAVPVGLLIASRLGGGAEFLAGSAAMGIRAVHLLAEQRA", "function": "Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.", "AFDB_id": "AF-Q9RS57-F1-model_v4" }, { "swissprot_id": "O51265", "sequence": "MKNINLILAWLVHIFTASGLIVGLYSIISIVNGNYSLLLKLTVIGLIIDGIDGTMARKLKVKELIPEIDGTLLDNITDYINYTFIPVIFFYLGEFIEEKYKVAICIGILLSSAYQFSRTDAKTNDNYFRGFPSLWNLFVILNIIFKMEQITNLITMSICIITSFIPIKFIYPSKTKELRKITIPITIISCLIFVVSIFSELSTTALKMAKTVLILYFAYLTLASIYLTYKTRNR", "function": "Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP.", "AFDB_id": "AF-O51265-F1-model_v4" }, { "swissprot_id": "A0A1D8EJG8", "sequence": "MKSTVASALLVLAGTAVQAQSGPWQQCGGIGWQGPFTCVSGHTCQVLNDWYHQCVPGGGPSPPPTSPPPTTPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPSSGSCPSTPGGLGSGNQRLPDPFTFHNGNTVTSAADFQCRQREVSSLIQQYELGQFPAPPQSVTSSYSGNTLSITVSDQGRSISFSVSISGGSGSKSPAIIAYGAPSIPVPNGVATIRFNNDDIAAQQSGSSRGQGKFYNLYGSGHSAGAMTAWAWGVARIIDALEKTPAAGIDPTRVGVTGCSRNGKGAMVAGALEPRIALTIPQESGSGGSACWRISNWQGQQGQNVQTPAQIITENVWLGPVFNNHANNVNALPFDHHQLAGLIAPRALYVIENSDMEWLGWTATYGCMAAARTQWEALGALDNFGFSQVGGNQHCSFNSGKQSAELNAFINKFLLQSGGGTTSILRTERNHGSFNLAEWTPWNVPNLR", "function": "Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin. Cleaves native lignin-carbohydrate (LC) ester bonds from LC complex preparations of spruce (softwood) and birch (hardwood), containing mainly hemicelluloses with partially acetylated glucomannans in spruce and partially acetylated xylan in birch. Can hydrolyze benzyl glucuronic acid (BnGlcA), allyl glucuronic acid (allylGlcA) and to a lower degree methyl glucuronic acid (MeGlcA) in vitro.", "AFDB_id": "AF-A0A1D8EJG8-F1-model_v4" }, { "swissprot_id": "Q9LVL9", "sequence": "MSEHHFVFVHGAGHGGWCWYKLANSLRDNGHKATCIDLKGAGINPTDPNTVSSLDDYDEPLYAFLSQLPNDQKVILVSHSVGGGSMTAAMCLFPSKVSLAVYVAAAMVKPGTLIPERLKNVMKICSGLIEEETEKIWDFTFGNGPQNLPTSIMMKPEYVRDKFYNESPMEDYTLATTLLRPAPVMAFIGIMDIPGAPETDKIPRVYVKTGKDHLFEPVLQEVMLALWPPAHTFLLPDSDHSAFFSQPQELYQFLLQAASSLSP", "function": "Methylesterase shown to have methyl indole-3-acetic acid (MeIAA) esterase activity in vitro.", "AFDB_id": "AF-Q9LVL9-F1-model_v4" }, { "swissprot_id": "Q802W2", "sequence": "MALMRCLLPPGFYRTLYHPWTRCASSGTLQIKDPLNFWCGARVDLKDVKTKSEPVFEPATGRVLCRLQTCGSAEVDAAVRNASAAFKVWRKLSGMERARVMLEAARLIEKRREEIAEMEVINNGKSITEARLDVDSARLSIEYFAGQATTLSGQHVQLPGGSFAYTRREPFGVCVGIGAWNYPFQIAAWKSAPAIACGNSMVFKPSPLTPVTAVLLAEIYRQAGAPEGLFNVVQGGQETGSLLCLHPSVEKVSFTGSVPTGKKIMEMASRGVKAVTLELGGKSPLIIFEDTDLENAVRGALMANFLSQGQVCSNGTRVFVQSSIVPQFLKEVVRRTKAISIGDPLLDETRMGALVSKAHLDKVLRYVEQAKNEGAQVLCGGEPFSPADPKLKDGYYMTPCVLDSCTDDMTCVKEEIFGPVMSVLTFDTEDEVLRRANDSDLGLAAGVFTKDVKRAHRVIENLQAGSCFINNYNITPVEVPFGGFKASGIGRENGQVTIEFYSQLKTVVVEMGDVDSLF", "function": "Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.", "AFDB_id": "AF-Q802W2-F1-model_v4" }, { "swissprot_id": "Q08537", "sequence": "MASPWPVWTLSWILILLAVLVPGAAADFNISSLSGLLSPVMTESLLVALPPCHLTGGNATLTVRRANDSKVVRSSFVVPPCRGRRELVSVVDSGSGFTVTRLSAYQVTNLAPGTKYYISYLVTKGASTESSREIPMSTFPRRKAESIGLAMARTGGMVVITVLLSVAMFLLVLGLIIALALGARK", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM.", "AFDB_id": "AF-Q08537-F1-model_v4" }, { "swissprot_id": "O43474", "sequence": "MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPGRPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQVPPLHYQGQSRGFVARAGEPCVCWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF", "function": "Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.", "AFDB_id": "AF-O43474-F1-model_v4" }, { "swissprot_id": "O43092", "sequence": "MFSVIGRGIKFSSKSHYSVSCFLIATQGAKIRQIHTHNTFFKNFSFAKLGRNQRTSSLIKIHNSSTSFPKSRSEKVVYTPSLPLSSSVLASFSFLPHNILQNGLNTLHIWSGLPWWASIAACAVAMRIAVFPIMLKMMKTSAKLAIINPKVAEHMSVLSKAKAEGNSELMMQATTQIQNLYKVNNVNPLNLLSAPVFQGILFISFFYALKTMAGVPVEGFTDGGFWWVNDLSQPDPLHIFPVANGLLMLLNIELGSETGSNKVAMSPSMKKFFRFLCLASPLFTMNFPMAIFMYWFPSNVFSVFQGAFLRSSTIRHKLGLPEVPSAMPVPNAQNESFVKSFTDIVHGVQEKGKYPQASEILDATRFLKTDTNNEQKPTNNSTITKATTLSDNSQNDKSSSVTKPTEKKD", "function": "Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. It is essential for viability while oxa101 is not. When both are deleted the cell is non-viable, suggesting that oxa101 act as a back-up for oxa102.", "AFDB_id": "AF-O43092-F1-model_v4" }, { "swissprot_id": "C8WQG7", "sequence": "MKWGRLLAFLAMVVVVLGLTISTGPKIWKSIPLGLDLKGGVDLLYAVDTPKGHPLDSTGKAALVRAIEMRVNSLGVSSPIIQLEGRNQLGQDQIRVEVAGVKNQQEAVSVIGATAQLAIYGSAKIDPKTGKIVPVGPPLATGADLKSNAHWVVDQQTGQNAVAIEFKNASLWTSITKRYLQKPIYVFLNGQLLTNPVVEQVMYTGQSEISGGNLTTPQACIDLANELNAGALPYPLTLESETSVGPTLGATSLHRTLIAGVIAVVLIFAFMIAAYRMAGLIADIALVAYGYLTLLTFAGLHVVLTLSGLAALILGVGIAVDANIITYERIKDEVRNGRSLRSAVRIGNKNAFRTIVDSNATTFIAGLIMYIFGGEGDVRGFAVALMVGIIVSLLTAVLFARAMLLTFTAAQAVKNPWWYGAPRGVVKSREAKV", "function": "Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.", "AFDB_id": "AF-C8WQG7-F1-model_v4" }, { "swissprot_id": "A1U2M9", "sequence": "MEFTFLGTSAGTPTRSRNVTGLALCLSGPKPWYLVDCGEGTQHQLMRTRYSVMQLRAMFITHIHGDHIFGLPGLLTSASMLGRTEPLDIIAPPQVRRFIDAVIENSDSSLSYPLNFINSEAPDFYWQDDHLGVTNVALSHRVPCRAYVFTERNLERQLQKEKLVADGIEPGPQWGDLQKGKDVLLDDGRLLRSNDYTHIPRTARKIIVGGDNDTPELLKDACQGTHVLIHEATYTQDVADRVGPWPQHSSAQQVARFAQATKLPNLVLTHFSSRYQSAPGGSPHINQLAAEALQHYKGQLFLARDFDTYRLEKDFQLHKVDHN", "function": "Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.", "AFDB_id": "AF-A1U2M9-F1-model_v4" }, { "swissprot_id": "P0AC17", "sequence": "MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETVVSHVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKENN", "function": "Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin at appreciable velocity.", "AFDB_id": "AF-P0AC17-F1-model_v4" }, { "swissprot_id": "Q6MAN0", "sequence": "MPHSFPDYSFTCPFCKNNCKLSFAQCPAFCPFCGKSQKNESTGLPIQSDFYQIIKSIGKGGMGEVFLAYDPCYERQIAIKKIRSDLLEHPQIKKRFLKEAHMTSQLTHPAIIPIYTIRSDADTAYYTMPFVEGDTLKQIIRKTKLQEKNGETLDYLGGSILALMRVFITICQAVAYAHSKGVLHRDLKPENIIIGKYGEVLILDWGLAKFIDQSPEEELLASFPESLTKQKDITKIGKVVGTVAYMAPERALGQPATIQTDIYSLGVILYQLLTLKSPFKRGTLDEFRKNMSREEWQDPVTAAPYREVPRMLASFTEKCLSLDLQNRYQSVEELIRDIENYLEGRSEWFCIANLNTKEKNDWEFQENVLIAEHVAITRMTDDAEWVSLMISKQSFTGNTKIEADVCLGEQGHGIGFLLSVPEASAREHLIEGYCLWLGSDFSKTTKLLRSNVEVVHAPDIFLKRQQTYHVRIEKVDKSIHVYINDNLQFSYIAHIPLIGTHVGLLSRDADFEISPLEIYVGNLNINVNCLAVPDAFLAHRDYNQALSEYRRIAYSFPDRTEGREALFRAGLTFLEQAKTAENKMPLLEEALNEFEKLHGTPSAPLEYLGKALAYESINDSEEEIKCYELAYRRYPNHPILPMLQEQIISRLHEVSRMQRITTYRFTLLTVRHLPLNKIDTHTKRLFNSLQKHWEVLPFIEYKSPSPLTTLSTRFATPLAFWLAKPFILGEILDDLIQSPPFPIEEVNNALLCLVELGSWEYAQEKLNTIQTYLNLPQNPKWLDLKAFIACHYQTLEDVYKDFFFQIPSTNADHLHAVLYFMDQCLDQLNTSLIYTLARQFEHAELSFEDRLRLNCRRVWAYLLDKNWQDAGNLLYTYSVETLNKDSSLLHFLYGCWLQVTEGAEIANVHFAGVNPVMFPRTWTLGARFLTNNLSKDSYEKAFMWEKRQLCKQLILYYHCVGNETKRIHFQKLYQEQFIHAEL", "function": "Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.", "AFDB_id": "AF-Q6MAN0-F1-model_v4" }, { "swissprot_id": "Q2J6B3", "sequence": "MFNGVGWGEVVVLLLIGLFVFGPDRLPKAARDAGRVLRQLRQLANGMRNDLRSELGPEFADLDIRDLHPKTFVRKHLFEDDPVLPPYLTKRTSLDSLLLGDDPPAAPSLTKSSLPRDPAAKDPARPGAEAAVPAAPPGPVSPMLSKVSPSKASAARSVPAQPARSDGPATEVPFDSDAT", "function": "Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.", "AFDB_id": "AF-Q2J6B3-F1-model_v4" }, { "swissprot_id": "Q9Y7R3", "sequence": "MKRASLGGHAPVSLPSLNDDALEKKRAKENSRKQRELRRSSALHSITPRRESLNNSSPFNSSHQVPVLSNFEEWIKLATDNKINSTNTWNFALIDYFHDMSLLRDGEDINFQKASCTLDGCVKIYTSRIDSVATETGKLLSGLANDSKVLQQTEEGEDAENDDEDLQKKKERKRAQRSVKTLVKDFESIRAKKFELECSFDPLFKKMCADFDEDGAKGLLMNHLCVDQHGRIVFDSSDTVIKDLENKDVEAESQEAVVAAPIESHDTEMTNVHDNISRETLNGIYKCYFTDIDQLTICPSLQGFEFDSKGNLDVSLLKSLSDEVNMITTTSLVDNTMEKTDADAASLSSDSDGEEGHIVHALEEMAYDEENPYVDVVPKAMDESENPDFGVDTEVNMADGSTMNENYSIISTAAANGVYEYFDKSMKKNWAGPEHWRIQALRKNINNASTVFNSSNTAESSDNVSRSLSSTERKKRRELDNAIDFLQEVDVEALFTPATSSLKLPKSHWKRHNRCLLPDDYQYDSKRLLQLFLKPKMSVLPNADGEGQLQLNKALDDENDLDGIQPHGFDSDGSDNVDEGIPPYGFGDSDSPKQTPLLTPPSSSGFGDNLLLTARLAKPDMLNYAKRAKKVDVRVLKEKLWKCLDLENTIKENSINSHIEGSEMESEETNMPVKSFFSTVNQLEETYEKKELKDISTSFAFICVLHLANEHNLELTSNEDFSDVFIRPGPNLTTLEALENDV", "function": "Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase in processes such as DNA repair.", "AFDB_id": "AF-Q9Y7R3-F1-model_v4" }, { "swissprot_id": "Q9UFB7", "sequence": "MGRLNEQRLFQPDLCDVDLVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALAPGGLQQILNFIYTSKLLVNAANVHEVLSAASLLQMADIAASCQELLDARSLGPPGPGTVALAQPAASCTPAAPPYYCDIKQEADTPGLPKIYAREGPDPYSVRVEDGAGTAGGTVPATIGPAQPFFKEEKEGGVEEAGGPPASLCKLEGGEELEEELGGSGTYSRREQSQIIVEVNLNNQTLHVSTGPEGKPGAGPSPATVVLGREDGLQRHSDEEEEDDEEEEEEEEEEEGGGSGREEEEEEEGGSQGEEEEEEEDGHSEQEEEEEEEEEEGPSEQDQESSEEEEGEEGEAGGKQGPRGSRSSRADPPPHSHMATRSRENARRRGTPEPEEAGRRGGKRPKPPPGVASASARGPPATDGLGAKVKLEEKQHHPCQKCPRVFNNRWYLEKHMNVTHSRMQICDQCGKRFLLESELLLHRQTDCERNIQCVTCGKAFKKLWSLHEHNKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCNERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVSHTLAGDGVPAAPGLPPTQPQAHALPLLPGLPQTLPPPPHLPPPPPLFPTTASPGGRMNANN", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q9UFB7-F1-model_v4" }, { "swissprot_id": "P35688", "sequence": "MIQNSAGYRSLNTASPMTVQVKNQKKICARCNKLVIPDSQRTKTTLKALGKYYHESCFTCQDCQKPLKPKYFPYQVDKTSESILLCQYDYFRRHNLLCHVCDTPLRGLYYTAFGYRYDEEHFSCTICATPCGVKKCFMYGNQLYCKYHFLKYFSKRCKGCEFPISDQYIEFPKGEEIHCWHPECYGIHKYWHVNLAAETVGLQYLPKLEYNPNSGDKDINPTAYELDKQMQAFNFILSKTWSVLYRFEEEAASCISDMFQYLTSNDQLKGIESTGLLVLKIDCLFRGLDTLNLSTNKSMPVNSDQECIENNAMAASKYSKFPKNLSTKIMIYLQLLRKLGTENKNETITISSFMSVITGLAHFLKLLTRFGLYTALENNKLTHSVNPLLRFLREVEKNELFENNPFQYIKTPVNATDSCAGCNKYIQEECIQFYEHRWHIACFTCSSCHKNINPRSLTDPTFNKEKKKILCSHCSIDDPASVPGFKFVTKLAQLIFLLKIALVKSRTVMLKSKASNKVGRNSLQSTMLKEQTYIRTLNDIKRLRSRRESVRVTHNKQQARKSVILETAETDLNDPTKQGDSKNLVIQTDDPSSSQQVSTRENVFSNTKTLTLDDISRIVAAEQARELRPNAFAHFKKLKETDDETSNVVPKKSGVYYSELSTMELSMIRAISLSLLAGKQLISKTDPNYTSLVSMVFSNEKQVTGSFWNRMKIMMSMEPKKPITKTVFGAPLDVLCEKWGVDSDLGVGPVKIRIPIIIDELISSLRQMDMSVEGIFRKNGNIRRLRELTANIDSNPTEAPDFSKENAIQLSALLKKFIRELPQPILSTDLYELWIKAAKIDLEDEKQRVILLIYSLLPTYNRNLLEALLSFLHWTSSFSYIENEMGSKMDIHNLSTVITPNILYLRHKEISNDNVPDEPESGLVDSFAQNKGENYFLAIEIVDYLITHNEEMAMVPKFLMNLLKDVQLQKLDNYESINHFISTVMQSKTIDYSECDIKTPVTVKDSTTTVIQGEINK", "function": "Acts in signal transduction. Activates CDC42, RHO1 and RHO2. Negatively regulates 1,3-beta-glucan synthesis. May be responsible for the down-regulation of CDC42 during mating.", "AFDB_id": "AF-P35688-F1-model_v4" }, { "swissprot_id": "O34616", "sequence": "MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDILFSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWYICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYIMTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNFIVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALIIYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS", "function": "Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation.", "AFDB_id": "AF-O34616-F1-model_v4" }, { "swissprot_id": "Q9LEV7", "sequence": "METLETEKFFSDDKPLLKPISDHSEIKTKARRNAVVSVLIQPFQWLQMLSSRLNLSFVLGVVLVYGVNQGFSGSIFKVVTDYYWKDVQQVQPSVVQLYMGLYYIPWVMRPIWGLFTDVFPIKGYKRKPYFVVSGVLGLVSAIAIVVLGKLPAALALSCLLGVSAAMAIADVVIDACIATNSINIRSLAPDIQSLCMVCSSAGALVGYATSGVFVHQLGPQGALGVLAFSPATIVILGFFIYEKRSSTVPTQKTKKDTDGLGVAVKGMCKTVKYPEVWKPSLYMFISLALNISTHEGHFYWYTDPTAGPAFSQEFVGIIYAVGALASMFGVLIYHKKLKGYSFRNILFFAQLLYVFSGMLDLVFIKRWNLTLGIPDSLFVITEESFTKMISKIRWIPMVVLSTRLCPLGIEGTFFAFLMCIDSFGQLASKWGGGFVLHAFGVTRHDFGNLWLVILIRNILRLVTVCFVFLVPDSDHLDDLVPSDVLPKKQSEDDDDDDIKLLLL", "function": "Could mediate folate transport.", "AFDB_id": "AF-Q9LEV7-F1-model_v4" }, { "swissprot_id": "O53547", "sequence": "MKLTESNRSPRTTNTTDLSGKVAVVTGAAAGLGRAEALGLARLGATVVVNDVASALDASDVVDEIGAAAADAGAKAVAVAGDISQRATADELLASAVGLGGLDIVVNNAGITRDRMLFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRDKAKDAEGGSVFGRLVNTSSEAGLVGPVGQANYAAAKAGITALTLSAARALGRYGVCANVICPRARTAMTADVFGAAPDVEAGQIDPLSPQHVVSLVQFLASPAAAEVNGQVFIVYGPQVTLVSPPHMERRFSADGTSWDPTELTATLRDYFAGRDPEQSFSATDLMRQ", "function": "A reversible dehydrogenase involved in cholesterol side-chain degradation. Catalyzes the oxidation of hydroxyl-cholesterol-CoA ester metabolic intermediate (22S)-HOCO-CoA (3-oxo-chol-4-ene-(22S)-hydroxy-24-oyl-CoA), the product of ChsH3, has no activity on (22R)-HOCO-CoA (the product of EchA19). Also acts on (3R)-hydroxyoctanoyl-CoA and 17-beta-hydroxyandrost-4-en-3-one, but not on 7-alpha-hydroxyandrost-4-en-3-one, uses NAD(+) but not NADP(+).", "AFDB_id": "AF-O53547-F1-model_v4" }, { "swissprot_id": "A0A0H3AJF5", "sequence": "MFVYGSIINPCPTEHVMSVLAISITTVALAEIGDKTQLLSLLLASRYRKPIPIIAAIFLATLANHALAAWLGVVVADYLSPDILKWVLVVSFLTMAGWILIPDKLDGEESISTRGPFVASFIAFFMAEIGDKTQIATSILGAQYADALSWVIVGTTLGMLLANVPVVLIGKLSADKMPLGLIRKVTAGLFLLMALATAFF", "function": "Involved in manganese homeostasis. May function as a manganese exporter.", "AFDB_id": "AF-A0A0H3AJF5-F1-model_v4" }, { "swissprot_id": "A8EXZ8", "sequence": "MHQYQIHWVEHSEVKILSNIVVRLEYKERGVKSITNRRARHDAVSESKSIDYSGKKHIALVAGGMSAEREVSLVSSKGVSKALIALGYKVTFIDMGADIAFKLQEIKPDIVFNCLHGTYGEDGCLSGLLNIMRIPYTHSGVLSSALAFDKIYSRSWFLTNNINMAESIVVNKSDNIKIEPMKRPYVIKPITQGSSIGIEVIFEEDDFNFANYDFPYGDQVIIEKYIKGRELQVAVLNGKALGVLEIKLLKNRFYDYETKYTEGFAEHLCPAPIPTNLYDKLLIESEKIYKTMNCKGPARVEFLLEDQTNKLYALEINTHPGMTPLSIVPEIAAYAGINFTNLIEEIIKAASFES", "function": "Cell wall formation.", "AFDB_id": "AF-A8EXZ8-F1-model_v4" }, { "swissprot_id": "Q6ZIB5", "sequence": "MIGWGDVYKVVGAMAPLYFALGLGYGSVRWWRFFTAEQCAAINTMVVYFSMPFFTFDFVVRTDPFAMNYRVIAADAVSKAIAIAAMAAWARTRCGCAAAKAGAQSWSITGFSLAALNNTLVVGVPLLDAMYGRWAQDLVVQIAVVQSMVWFPLLLMAFELRKAWVVGGGGGVGPAVMSSSSPPEKQSDVEMNGAVVAAPGGGGGVRLPFWATARTVGLKLARNPNVYASVLGVVWACIAYRWHLSLPGIVTGSLQVMSRTGTGMSMFSMGLFMGQQERVIACGAGLTALGMALRFVAGPLATLVGAAALGLRGDVLHLAIIQAALPQSIASFVFAKEYGLHADVLSTAVIFGTLISLPILIAYYAVLGFV", "function": "May act as a component of the auxin efflux carrier.", "AFDB_id": "AF-Q6ZIB5-F1-model_v4" }, { "swissprot_id": "P11900", "sequence": "MKKTLIALAVAASAAVSGSVMAADWTEGQPGDIIIGGEITSPSVKWLWKTGEGLSSFSNTTNEIVKRKLNISVPTDELFLAAKMSDGIKGVFVGNTLIPKIEMASYDGSVITPSFTSNTAMDIAVKVKNSGDNTELGTLSVPLSFGAAVATIFDGDTTDSAVAHIIGGSAGTVFEGLVNPGRFTDQNIAYKWNGLSKAEMAGYVEKLMPGQSASTSYSGFHNWDDLSHSNYTSANKASYLSYGSGVSAGSTLVMNLNKDVAGRLEWVAPVTITVIYS", "function": "Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.", "AFDB_id": "AF-P11900-F1-model_v4" }, { "swissprot_id": "Q61473", "sequence": "MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSPLGDVKVKGEVVASSGAPAGTSGRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALVEPQAGALGPEGGRVAMDGLGLPFPEPGYPAGPPLMSPHMGPHYRDCQGLGAPALDGYPLPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGTYTYAPVSDYAVSVEPPAGPMRVGPDPSGPAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQAPPPPPQQQHPAHGPGQPSPPPEALPCRDGTESNQPTELLGEVDRTEFEQYLPFVYKPEMGLPYQGHDCGVNLSDSHGAISSVVSDASSAVYYCNYPDI", "function": "Has no DNA-binding activity, and does not function as transcriptional activator.", "AFDB_id": "AF-Q61473-F1-model_v4" }, { "swissprot_id": "Q83F15", "sequence": "MKRYNAKRKTHRNLKSIKKLIPTVLALLAFVSLLAGIITLHNPKTLPFRQIKITVSSDHIKMAELKDIVVHHIQGGFFSFNASALQTALMSLPWVHDVSVRRIWPNELEIQVEEQRPIARWNQNELITQEGEIFSPPIETIPQNIPQLSGPNDSEENVLNRFQQFSQLLIPFHAAVTALSLTKRGAWSLILNGHTQIFLGRENIDQRFEQFVHLYPKIIGANINRVEHVDLRYSNGLAIQWKN", "function": "Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.", "AFDB_id": "AF-Q83F15-F1-model_v4" }, { "swissprot_id": "D5SL78", "sequence": "MQEFEFAVPAPSRVSPDLARARARHLDWVHAMDLVRGEEARRRYEFSCVADIGAYGYPHATGADLDLCVDVLGWTFLFDDQFDAGDGRERDALAVCAELTDLLWKGTAATAASPPIVVAFSDCWERMRAGMSDAWRRRTVHEWVDYLAGWPTKLADRAHGAVLDPAAHLRARHRTICCRPLFALAERVGGYEVPRRAWHSSRLDGMRFTTSDAVIGMNELHSFEKDRAQGHANLVLSLVHHGGLTGPEAVTRVCDLVQGSIESFLRLRSGLPELGRALGVEGAVLDRYADALSAFCRGYHDWGRGASRYTTRDHPGDLGLENLVARSSG", "function": "In vitro, catalyzes the formation of R-linalool from geranyl diphosphate (GPP). Can also accept farnesyl diphosphate (FPP) as substrate to produce trans-nerolidol.", "AFDB_id": "AF-D5SL78-F1-model_v4" }, { "swissprot_id": "Q09835", "sequence": "MKSMLLRDSVKKASQFQRSLHSDPNQAKILLEERRKLLEEANSSADENDSHSMATIKSHFERLKRDEQLLNGVLKKYDAKQEVLSPEELRDAQNFLEMQEANSLDNSIRGTNELLERAYATREDFDYQNSVLGNVTNRINGAAMSIPFINQILRKTSIRRRRDSIILALLISVLMLLFLFFH", "function": "Nonessential SNARE involved in retrograde transport within the Golgi complex.", "AFDB_id": "AF-Q09835-F1-model_v4" }, { "swissprot_id": "Q9SPK6", "sequence": "TFHKPVSGASALPHIGPPPHLHRSFAATTMLSKLQSISVKARRVELARDITRPKVCLHAQRCSLVRLRVAAPQTEEALGTVQAAGAGDEHSADVALQQLDRAIAERRARRKREQLSYQAAAIAASIGVSGIAIFATYLRFAMHMTVGGAVPWGEVAGTLLLVVGGALGMEMYARYAHKAIWHESPLGWLLHKSHHTPRTGPFEANDLFAIINGLPAMLLCTFGFWLPNVLGAACFGAGLGITLYGMAYMFVHDGLVHRRFPTGPIAGLPYMKRLTVAHQLHHSGKYGGAPWGMFLGPQELQHIPGAAEEVERLVLELDWSKR", "function": "Nonheme diiron monooxygenase involved in the biosynthesis of astaxanthin. Hydroxylates beta-ring of beta-carotene and catalyzes the conversion of canthaxanthin to astaxanthin. Uses ferredoxin as an electron donor.", "AFDB_id": "AF-Q9SPK6-F1-model_v4" }, { "swissprot_id": "Q1LYL8", "sequence": "MGVQGLKTYIESSSRNDLKTWAFRDKQLIIDGCNLFYSLCFDSNLDQIHGGDYDTFEKVVRQFFENLSACDVHPYVVIDGGDDHTDKKWDTLLTRKQKKIKDAYDLSVGKRRQVLPLLTEKVFKQVLKKLKVPVVQTLEEADWEIAALAEEWNCPVLSNDSDFYIFNLRAGLLPITHFHWRKVRVNRKTNQKFILSKHFIARKFCKSFKMNVSLLPVFASILGNDYVKLPNIKNRHWERYSNPGSENPQIEGLLNWLSQFSGPDEAISALLRPTSNKTKAQEELSHGIQDYKLVPGSLAQIFRSTKVPQKISKGPLHVLPRWTLRPILDGKMSSYIINVLLHNRASLNAQVEDFQLPSANETSLHIRQVFYGLLLLGEQQTAGKRESVKGTTKRYVVEYSRQQIKRSSENVEAIQTKAMEGLRLETLYQEPHAVRLQVILDTLGVSCEMLKGTPDALQLQMFVTRYWLVNAEPQPCRVHLWGLLLGMVYGKLSSSPNAQKDMLSRLRVKASRKGGSVDIDVAHAYSQWQSCLKYSLNLNYLLSFPLTEPDCASLYRGSLVHQAVGELRRGISLEALLVKGSSAERIFKQLKDIIVSLMGDDFIKKMKSGLEHRDAGKTQRASKGQKDELDIYFEQMMIESIDSEDEELLDVRKSKAKNHLMELPVCPIRARHKAKARNARHPCKKYERRCFE", "function": "Possible role in EGF receptor signaling.", "AFDB_id": "AF-Q1LYL8-F1-model_v4" }, { "swissprot_id": "Q9SU75", "sequence": "MAERLLQSMSRVAGRCHPDCVKASDEQEDYHASQNAALVAVNLISSARLILKLDAEFTEYSAQFLMDNAGKEDDPGEVDQQRNQVTTENCLRYLAENVWTKKENGQGGMDQQRPVLTVKDCLELAFKKGLPRREHWAHLGCTFKAPPFACQIPRVPVKGEVVEVKTFDEAFKLLVHQPIGAKLHLFSPQIDNVGEGVYKGLTTGNETHYVGLRDVLIASVEEFEGDSVAIVKICYKKKLSFIKVSLSVRFLSVAHDGDKSKFIAPTGLLVDFCVPRLSIN", "function": "Mediates both basal and acquired thermotolerance.", "AFDB_id": "AF-Q9SU75-F1-model_v4" }, { "swissprot_id": "P39081", "sequence": "MDHDTEVIVKDFNSILEELTFNSRPIITTLTKLAEENISCAQYFVDAIESRIEKCMPKQKLYAFYALDSICKNVGSPYTIYFSRNLFNLYKRTYLLVDNTTRTKLINMFKLWLNPNDTGLPLFEGSALEKIEQFLIKASALHQKNLQAMLPTPTVPLLLRDIDKLTCLTSERLKNQPNDEKLKMKLLVLSQLKQELKREKLTLNALKQVQMQLRQVFSQDQQVLQERMRYHELQQQQQQQQQQQQQQQQQQQQYHETKDMVGSYTQNSNSAIPLFGNNSDTTNQQNSLSSSLFGNISGVESFQEIEKKKSLNKINNLYASLKAEGLIYTPPKESIVTLYKKLNGHSNYSLDSHEKQLMKNLPKIPLLNDILSDCKAYFATVNIDVLNNPSLQLSEQTLLQENPIVQNNLIHLLYRSKPNKCSVCGKRFGNSESEKLLQNEHLDWHFRINTRIKGSQNTANTGISNSNLNTTTTRKNIQSRNWYLSDSQWAAFKDDEITSTKHKNDYTDPHANKNIDKSALNIHADENDEGSVDNTLGSDRSNELEIRGKYVVVPETSQDMAFKCPICKETVTGVYDEESGEWVWKNTIEVNGKYFHSTCYHETSQNSSKSNSGKVGLDDLKKLVTK", "function": "Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex. Independently involved in RNA polymerase II transcript termination. Binds RNA. Seems to bridge RNA polymerase II and the native transcript and may be involved in dismantling the RNA polymerase II elongation complex.", "AFDB_id": "AF-P39081-F1-model_v4" }, { "swissprot_id": "Q4P4R3", "sequence": "MSIILPDWVAHHNDDKKGKLSTIFSVAVHPDSSRLATAGLDTKIRIWATATILNPRAENNSNSHRLLSTLSRHTGSVLVVRWANSGRFLASGSDDTVALIWDLDPSGMGGGSFGSSEVNIESWRPYRRLAGHESDVVDLAWADDDEFIATVGLDSKVIVWSGTHFDRLRIIDGHQGFVKGVVFDPLGQYLATASDDKTVKVWRTSDWGLERSITDPFLTSPSTAFFRRPSWSPDGSLLLCANAMSGPVFVASVVKRSSWSSDIYFVGHENAVVVTAFSPKIFVGFDGGTHSCVVALGSLDQSVSIWVTGLEQPVLVARDVFERQVMDLSWSADGYTLYACSSDGTVAVFHLSPELISDALSAEKLEQSRAKHGVKRVRNVAAATNGALPIGTSDRPNMLQPRKAGQSQAARASVPPVPIAGSVPPVRPIASRTERLHQTITITKDGKRRIRPTLIGDDLEPSQAVSHHHAYQPAPTSHALMPSIQQHQLPAMREAIGGTTVDGFGARPGVNGIHAGMTNSVSDGTAAAVVEAVLAAQRSNPAAMTTPMAAASSMMPYVPIGLPFGIMPEGASPEDMMQFWTEFQQRFMRGKKRKAEDAEAGSDSDDIEPIGKLQKGKTRADIGRTLGSEHPRDPPGPKKVLREALTGASGIVENGVRKGVHLAVPETLSIYRRDEDGLSIEIRNFDESRPTEIARLDPSDKDRVLWLDFSPTAATLATATSFFSAVALEDSTVLIYSSRGGRIGNLLLDSACYRLESNGVVLMAVTVAGLMYRWNIRADHEIHRPVSVLNLLGDPENLFSITVHANGAPIVILQSEKAYTFDDKKLGWVCISDGWWAEHSEAWDGRTRSRGSEVSVRDPVRAIEAEINTMYVRRVHGDNQVGAQEESDDDQTPPVEMSVPEDKKSDFVIAVTLRHLEARILAATILDSANEYKNHLIAYAKRIAEEGIKNQAEDLIKSLIGPIYYKPEKNQDAAWQPTILGFDKRQLCGQVLQILARPRNLTSLVQPYQEILANMKA", "function": "Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.", "AFDB_id": "AF-Q4P4R3-F1-model_v4" }, { "swissprot_id": "Q9XU75", "sequence": "MRYLCKSILLAVHTILLVGSVCCSTDVHNTDDKYALIHVSAHDEQSLHLIKQLQLNDFKYDLDFWKSPSSISDKADIMVKRGKSERMLRQILSFANVTVSMSVPDVEKLIMRNEGTTSKSHLGFGSLSKWLHDDPILDSEPDLDLTKVGALKKAKYPFGDYASYADMVKYMRTIEFYYPRIAKIVRIGATHEGKPIEGLKIGARSSHKKRAVWVDGNIHAREWASSHTALYFINQLVSEYGKDAQITNYVDTLDFYIVPCLNPDGYEYTRTSPIPTVRLWRKNRSPELCRPSLWGGEKCCRGVDLNRNFRFHWAERGSSYEPCSNIYHGEEVFSEPETRAVRNFLATPEMKDRVDAFVTLHSYAQLWIYPYSHEEQNYPEDIGELRKTARKAINRLSRVYGTNYRMGTGADTLSPAAGGSDDWAKSALNVKYVYLIELRPQMELSNGFILHKKELIPTAVETFEGFREVVDAVLTLNNSTSSIGLSSGSNTSRKTISDLQMRKQQYRMRLLASQAAGSTTRSTTTLKTSTTSVSTTSEATSPSKTSRHFDRFTADLNSSTRARPTPPMAPPIMSPSTEFSTTTTEEEDVTGVIRSSSIASRATTYGFFTATKPSAFLDPECRDMRYSCGFWLKNNKQVCEEQQSFMRAQCAYTCKFCTSFIKRH", "function": "May play a role in processing or organization of cuticle collagen proteins, including rol-6 and col-19.", "AFDB_id": "AF-Q9XU75-F1-model_v4" }, { "swissprot_id": "Q487R3", "sequence": "MKNLLSLCFLMLAAFTLNPAAAQEKQSIFDVSNSSLFSNDDEFLKVDQAFAFNFYQKNNLLEVSFDIAPEYYLYRHQFKFKGKNTQFTSVLLPDGIDHEDEFFGVQKIFTENLAFTVNLENVSNDASIKITYQGCAEKGLCYPPTSKVIKLSKFILGESTSAPSSDAAQQTNEGEVKKSEQHQLSDMLKQDSLLLTLIAFFVGGLLLSFTPCVFPMYPILTGIIVGQGEGLTTKKAFTLSFFYVQGMAITYTLLGVVVAMAGAKFQAVFQHPIVLIGLSILFIFLALSMFGVFNLALPASWQNKLNNVSNKQKGGSITGVLMMGVISGLVASPCTTAPLTGALLYISQTGDVVLGASALYALSLGMGLPLLILGSSGGKLLPKAGAWMNIIKNIFGLLLLAVPVFLLERFIPEVASQALWALLILVSASYFYVANQNHAAAQNVQQGKGFWYGLRSLVIFLMLFFGANLAYQLIYPSSNNVTNNAQHASFKQVTSLAQLEDEVKKANMQGKTVMVDLYADWCIACKEFEKYTFVDADVQKALSNSVWLQIDMTEFDSTDNAELVQHYTILGLPSILFFDLQGNELTKQRTTGFMKAAEFSAHVKSIFK", "function": "Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.", "AFDB_id": "AF-Q487R3-F1-model_v4" }, { "swissprot_id": "Q7TXJ4", "sequence": "MRVSCVYATASRWGGPPVASEVRGDAAISTTPDAAPGLAARRRRILFVAEAVTLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLPFRHHAIHTIPSERFFGNLTQGRFYAMRTLRKYVEADLRVLDEIAPDLVVGDLRISLSVSARLAGIPYIAIANAYWSPYAQRRFPLPDVIWTRLFGVRLVKLLYRLERPLLFALQCMPLNWVRRRHGLSSLGWNLCRIFTDGDHTLYADVPELMPTYDLPANHEYLGPVLWSPAGKPPTWWDSLPTDRPIVYATLGTSGGRNLLQLVLNALAELPVTVIAATAGRSDLKTVPANAFVADYLPGEAAAARSAVVVCNGGSLTTQQALVAGVPVIGVAGNLDQHLNMEAVERAGAGVLLRTERLKSQRVAGAVMQVISRSEYRQAAARLADAFGRDRVGFPQHVENALRLMPENRPRTWLAS", "function": "Catalyzes the transfer of the first rhamnosyl residue on p-hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O-methylation at position 2 of the sugar unit, mono-O-methyl-glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl-phenolphthiocerol dimycocerosate (also called mycoside B) during p-hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.", "AFDB_id": "AF-Q7TXJ4-F1-model_v4" }, { "swissprot_id": "C0LGF4", "sequence": "MMGICEMKSCCSWLLLISLLCSLSNESQAISPDGEALLSFRNAVTRSDSFIHQWRPEDPDPCNWNGVTCDAKTKRVITLNLTYHKIMGPLPPDIGKLDHLRLLMLHNNALYGAIPTALGNCTALEEIHLQSNYFTGPIPAEMGDLPGLQKLDMSSNTLSGPIPASLGQLKKLSNFNVSNNFLVGQIPSDGVLSGFSKNSFIGNLNLCGKHVDVVCQDDSGNPSSHSQSGQNQKKNSGKLLISASATVGALLLVALMCFWGCFLYKKLGKVEIKSLAKDVGGGASIVMFHGDLPYSSKDIIKKLEMLNEEHIIGCGGFGTVYKLAMDDGKVFALKRILKLNEGFDRFFERELEILGSIKHRYLVNLRGYCNSPTSKLLLYDYLPGGSLDEALHERGEQLDWDSRVNIIIGAAKGLSYLHHDCSPRIIHRDIKSSNILLDGNLEARVSDFGLAKLLEDEESHITTIVAGTFGYLAPEYMQSGRATEKTDVYSFGVLVLEVLSGKRPTDASFIEKGLNVVGWLKFLISEKRPRDIVDPNCEGMQMESLDALLSIATQCVSPSPEERPTMHRVVQLLESEVMTPCPSEFYDSSSD", "function": "Involved in the signaling pathway that regulates cell wall function, including cellulose biosynthesis, likely via an 1-aminocyclopropane-1-carboxylic acid (ACC)-mediated signal (a precursor of ethylene).", "AFDB_id": "AF-C0LGF4-F1-model_v4" }, { "swissprot_id": "I1RV20", "sequence": "MLKRRSACERCRGQKLKCIREPDNRTDSCLRCSQAREECVVNLRKTPGRPSGRTNSSSRRSPPSNTTPPTQTPTPAPTLVHDDSDSISVPRNGSFASSSEDALEGLLDMNIDWGDMNMFSLSGNGADQVPEIPSSLFSFAESTRVEPPPPCASWSASGDFAAPTGLFPCQIRNEICDPGIQLSGLQQSLSKHLVQLQSFSWDITAVLKLESASFGFQTPESLCEASRSFNPLVGTFEIISEFENVLEILRNAVKRRERQEVPTLPKEMLICYSLTAISCYLQLVCVYNNLFSYVLDQASSNLAVRTFVLDSTPVISLSGFVIPSPKNIVGRSFAQLMQHKIGSVEAALGLPDDWRISKDLSSHQSADRPLLLGGKEGQALLELLKGQAVEGESLSSAMGLLESVRDKITEIECLA", "function": "Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat.", "AFDB_id": "AF-I1RV20-F1-model_v4" }, { "swissprot_id": "Q9K492", "sequence": "MSTDVSSAENEGGATVRTARVPKYYRLKKHLLDMTRTQTPGTPVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSQDRTGQPVEWVRSVYRGDRYKFVARLKRPQD", "function": "Global regulator that is part of the nutrient-sensing system. In the absence of glucosamine 6-P (GlcN6P), represses the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Also regulates the expression of the ABC transporters DasABC and NgcEFG, which are involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Binds to the DNA consensus sequence 5'-ACTGGTCTAGACCACT-3'.", "AFDB_id": "AF-Q9K492-F1-model_v4" }, { "swissprot_id": "O83505", "sequence": "MARISAHVIDAIADRVDLVSLVGNYTHLERRGDDWWGRCPFHHERTPSFHVVPDKKMYYCFGCGVGGSTIKFFMEIEKIDFHEAAVRLAKRAGIEMSFEDGVHAPSAHASFTMQLCEVYQRIAETFHHVLMHTAQGARARAYLASRKVTDDSIRTFKLGYAPPDPVWLFQFLRHKGYSPEFLARSGLFAKKSERIAVFSDRIMYPIADRYGQVIAFGARALGTAPAKYLNTADMPQYKKGEHLFAFHCALSQMRKTRAAIICEGYMDVIAFHQAQLTYAVAPLGALLTKSQARLMRSFVDRIYMCFDADGAGRAATYKAILLCRSLGFEVRIVELNGGTDPAECACIEGEDALRKSVERSTTDAQYLIRCARHEHSHLGADDTSRAVSFLFPYLSVLDSAIQREQVMQDIAMAFGIRIQAVHADYLRYVSRTTQKGTTGNCVLSVQGTAIQVKEPATGVRTAQLRLVLAVVANPELFELLRESVCADDFEDPMAKELFIILEECYRADTRASPHVLSCCTTDELRKLVSEAIVCGEFSCNAPQIVRDGVALVRRNRLLKERESLVGRLRRFGDASSGEECGSMQELMMEKQRVDEELERLKGVRK", "function": "RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.", "AFDB_id": "AF-O83505-F1-model_v4" }, { "swissprot_id": "Q8DGH7", "sequence": "MITVLVLNAGSSSLKASLYRLAPEIGATAVRPPAPLWQGLLDWGQNPTVARLKVTTANQHYEANLTHPEGGIAGLRDWLKSLLDTLTSGQTKLLENLAEITIIGHRVVHGGSRYQAPVRVDAQVKAAISELSEYAPLHNPANLLGMELMADICPQTPQVAVFDTAFHAQLPAVARTYAIPYELTTAGIQRYGFHGISHQYVSERAATLLQRPLAELHLITCHLGNGCSLTAVKGGVSVETTMGFTPTAGVMMGTRCGDIDPGILLYLLRRGWTVAELDRLVNRQSGLLGVSGVSNDLRQILAAIDQGNPQAQLAYDCFIYSLQRGIASLLPALGRLDGLVFTAGIGENAPGVRRDICRGLGWLGIELDSTANEKGQGDRNIALPTAPVSVLVVQTQEDWAIARACGQLLSLPISS", "function": "Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.", "AFDB_id": "AF-Q8DGH7-F1-model_v4" }, { "swissprot_id": "P83453", "sequence": "MAGTGHTPEEALALLKRGAEEIVPEEELLAKLKEGRPLTVKLGADPTRPDLHLGHAVVLRKMRQFQELGHKVVLIIGDFTGMIGDPSGRSKTRPPLTLEETRENAKTYVAQAGKILRQEPHLFELRYNSEWLEGLTFKEVVRLTSLMTVAQMLEREDFKKRYEAGIPISLHELLYPFAQAYDSVAIRADVEMGGTDQRFNLLVGREVQRAYGQSPQVCFLMPLLVGLDGREKMSKSLDNYIGLTEPPEAMFKKLMRVPDPLLPSYFRLLTDLEEEEIEALLKAGPVPAHRVLARLLTAAYALPQIPPRIDRAFYESLGYAWEAFGRDKEAGPEEVRRAEARYDEVAKGGIPEEIPEVTIPASELKEGRIWVARLFTLAGLTPSNAEARRLIQNRGLRLDGEVLTDPMLQVDLSRPRILQRGKDRFVRVRLSD", "function": "Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).", "AFDB_id": "AF-P83453-F1-model_v4" }, { "swissprot_id": "Q8GAI5", "sequence": "MQTRYGRRALTIWPLLLLAIAAEVAATSLLPQTNGFRKLKPTVAVACLYTVAFALLAQILKFTDIGIAYALWAGLGTASVAVIGVLFRNERFSWKHAIGLALVVTGVVTLNLQAGQ", "function": "Component of an efflux pump responsible for the transport of nicotine breakdown products, in particular methylamine, out of the cell. This pump apparently serves as a metabolic valve for nicotine catabolites and may protect the bacteria from the potentially toxic side effects of these compounds.", "AFDB_id": "AF-Q8GAI5-F1-model_v4" }, { "swissprot_id": "O63852", "sequence": "MNQIPMQYFNLAKENYSKYGLSVIQLIQIGKFYELWHEPDTSSKQQAYSQAELLVESSIRSRSLEVTPPIEQVASLLDMKIISLGKRSLLQMGFPVYSLTTHLSTLLDKGWTVIVIDELVTNKSGPKQRAVSQVYSPSCNLEDCPELPYVLSIYFSQDDLLGITLFSAMNGHSIIFPVSWTDRDKVTRLLISYHIREIVIWADSGVCSNILINKIYNLLIGWNLFPSEPNAKIEAMGEILTNLPCYLSYRYENNSKEWLLLHIYIGINTEWLNKNYQKYTLSKIFQSTWTENVNQANLISLLGVLQFIKDRNPNLIKNLQLPECYNSVVSPLNLILCNRAEYQLDLLSKRGKLGGLLNLIDYCSTAMGKRLLKFRLLNPITDYSELNLRYKDISIFKRLLNQKIFDNSELKCIKDLSSLHRQWAICASSDTTLPPKKLSQIYHSYLFACQLISKLTNNIQLPPLVGPQLKSLIKEIERIFQVDSLLGDFKDVIQPIGNLPNLFEQRQTLRAQLTEWAEQISNIVFQDTTSIKAEYFNKEGYAFSISSKKLTKLEHYMMNTSISNNSIIVLGKRGSHHIITSPTIHKVSIELNELEEQINIYVKQTYHQELKRLYFSYSELFLPLVNMISRLDVALSGAITAIKFNYVEPCLTLAKTQQTKGFIEAANLRHPLVEQLNTQEECIAHNISLEDKGMLVFSVNGAGKSTLLRAIGVNVILAQAGMYVAADSFKLRPYNYLITRILGGDDLYRGQGTFEVEMRDLSTILQLANYNSLILGDEICHGTEVNSGTAILAATIERLINAQTSFVLSTHLHQVCSLIDSPVRYYHLSVIQQENSALIYERKLKPGPGPSQYGIEVMGHIINDKKFYNSALKYRKLINWEPPSQGELTVFRPSKYNAQVFIDSCEICGAPADAVHHIKPKSEHKKLCNRKLNRRSNLVPVCSSCHLDIHRNKISILGWKRTPKHKKLYWVYTNESLDSGTK", "function": "May be involved in DNA-mismatch repair.", "AFDB_id": "AF-O63852-F1-model_v4" }, { "swissprot_id": "O05942", "sequence": "MVNLKIFLIVIVLMFNNIILAKENSNALKVVDQEENEFTAINSAPLKISEAARYSFADIVEPLIPAVVNISTIEYVNDKSENSEKDLLQENKHLGFMSDVLEKLNIPLNLEEIAKTPKSIPLGSGFIIAPNGLIVTNYHVIANVEKINIKLADNTEFLAKLIGSDSKTDLALLKIDSEEPLPFVEFGDSNDARVGDWVIAIGNPFGNLGGTVTSGIISSKGRDIDVDTDNIVDNFIQTDAAINNGNSGGPMFNLDQKVIGVNTAIFSPLGTNIGIGFAIPSNTAKPIIERLKKDGKVSRGRLGVTIQDLTEEISEVLGFKGTNGVLVSKVQENGPGYKAGIKKGDIIIKFGDRLVKNTKKLRVIIADTPINQEVKLKILRDAQELELPIKVTADNEEVINDSTEETNKAVIINKKENNLSITKNNITFSNLTEELRKKYDIPQDKTGIVIINIDEEESVFKLGDLITNINHDSIDDIRKLEVLYENAKKLEKQNILLLIERGDTSVFIPLSVS", "function": "Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.", "AFDB_id": "AF-O05942-F1-model_v4" }, { "swissprot_id": "Q9LPP4", "sequence": "MDLELLQDLSKFNFPTPIKIRSKTSKTKKDEGDDDEDDLRCSTPTSQEHKIPAVVDSPPPPPRKPRPPPSAPSATAALMIRSCKRKLLVSTCEIIMNREEIDRFFSSVYNETSTTAKRRRSYPYCSRR", "function": "Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle. Cooperates with SIM and SMR2 to promote endoreplication during leaf development. Specifically regulates endoreduplication in epidermal pavement cells to produce the cell size pattern. Is necessary for giant cell formation. Positive regulator of effector-triggered immunity (ETI).", "AFDB_id": "AF-Q9LPP4-F1-model_v4" }, { "swissprot_id": "P72686", "sequence": "MAASLSQQINNPERSYFEQALKRVEQDVLRMGALVEESFRMSHQALFENRLETPLKIAELEKEIDRLYRHIEQECASFLTLQAPVAQDLRLLSAIMQLVRDLERIGDYAQDLGEIAMKLTRYPPHPCMDEIAAMAWQAQHMLDQSLVCLTQLDPNAGEIVKKMDDVVDDAYDRLYKTLAFQRDIKGVVEPILLMALVIRHLERMADHATNIAQRVSYIVTGKRE", "function": "Plays a role in the regulation of phosphate uptake.", "AFDB_id": "AF-P72686-F1-model_v4" }, { "swissprot_id": "B0K5J3", "sequence": "MQGIAKIKEKIFEEATEQKNRIIEKAKKEAAEILEKARKQAVQLEAEAEKKAKKVAREEKRKILSIAELEERKRYLEAKQALINEAFVSAEKKLLNLESEKYRDLVYRMILAAAVDGNEEIIVSEADKEKITPELLERVNEALKKQGKAGNIRFSGEKRAIKGGFILKSATVEINCTFDYLLKVQREELETEVARILFEE", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-B0K5J3-F1-model_v4" }, { "swissprot_id": "Q19143", "sequence": "MGRAMRVVVVGGKKVGKTAILRQVACVEDVTNKPYEPTIEDTYQVLLEEPDKAREILILHDTAGVSNYGPIELKKAYVQAADAFVLVYSSADYESFNRVDLLKKWIDRQFGKDKKEVPIVVLANMRDRPATVDSAFAHSWAAREKVKLFEVTAKDRQSLVDFIHYVGHRHFHPTKESKFSLSKKLKSEKSSNPAILMDF", "function": "Atypical Ras-like protein that may act as a regulator of NF-kappa-B activity.", "AFDB_id": "AF-Q19143-F1-model_v4" }, { "swissprot_id": "Q9CA66", "sequence": "MADHTTKEQKSFSFLAHSPSFDHSSLSYPLFDWEEDLLALQENSGSQAFPFTTTSLPLPDLEPLSEDVLNSYSSASWNETEQNRGDGASSEKKRENGTVKETTKKRKINERHREHSVRIISDITTYTTSSAPTTLSKETVSRYFYMPITQAAIALNVGLTLLKRRCRELGIRRWPHRKLMSLNTLISNVKELQKMEGEENAEKLQDALEMLEKEKRTIEDLPDLEFKDKTKRLRQACFKANHKRKKKRSLKSDQSQVPSCSSSGSVPSDESVDEAGMESDEEMKYLLCGFSSEFTSGL", "function": "Putative transcription factor.", "AFDB_id": "AF-Q9CA66-F1-model_v4" }, { "swissprot_id": "Q07533", "sequence": "MATNLTSLKPPFKVKARYGWSGQTKGDLGFLEGDIMEVTRIAGSWFYGKLLRNKKCSGYFPHNFVILLEERLNSSTENGRQPSKIVESFEKSNKVVIPPVPSRYSDERPRPKKKLSSSMPNSPKKPVDSLTKARKAKSKEMVNEKNIYNTQSSRHHNNSAPNLPLASHSKPQVRNFEESMNNPLPPLPPLPDLDNMRKTDKRAPKKSYSANDLHMARSSREYNYYKDNQKFYDGFIPEKRYSLEEDSISSGLFSNSQYLNDSACSSENSFALMSDFSATSAGSFARHKYAQSFSDSLQRSQNANGCSTKINDSQEFGDSNASSRNGKMGDILRKIIIPKRNTNIYSSSVSSPKSPKAYPKLPDIQNLNLSATPDEARDWIAVKCHLNRARTLTKYDKHPRYMRALEENRDLILHPQDSIYNGLNTNEVKGNTKPGLVDVELAELNIEYIDKMTWKRCIRDGTMTLDSWAQTTFSARYSTVLEKLRGIYIFCTEMFALTDDNGTSDFSAEPQNLEKILYRKHCTPYELTWLFKKLANSLGITCEIVIGFLKTPSAINWEFKYNHCWLRILVNKEWRFIDVILGNVTNPIHEFVNNRKIKKAENSYFLMAPLEMIYTHIPPREFEQHIVPSIDQLSALYLPLVFPSFFKNELKLYKFSTALSFLEDSEIYECSLEIPNDVEVFASVVIPTDNEEASSAYRNMELALTQIKKQKAESGRRIALIKAVLPPNVNKGSLYIHSGVRGTQTSIANIHPLSMMVPLTHKGSNMKYEFVIKIPSESIQKIELYIVEPQSRYLFVGNEYSFEVIQSPSDGIVYSSDEGPNQNRKQPMAIKSPSGRVHELVKSDPHFPYGTWKGSIKIKEPGVWSALVIADSGIGWSVFAEWLCV", "function": "Involved in cytokinesis by recruiting INN1 to the bud neck. Cooperates with INN1 to stimulate the synthesis of the primary septum (PS) by CHS2.", "AFDB_id": "AF-Q07533-F1-model_v4" }, { "swissprot_id": "B8NTZ9", "sequence": "MPSQVLTHEEEYDLAVRQGKGLAQQFFDHAFLNPSAMAVIDGDTNLTYQDLHERAAMLARELQRGNLHTEEPVGVVVQHGISDVVAQMAILYAAGTCVPMDPTLPDLQIKGRLDRLKARYILVDRANQHRDLPFHPLIVDDSSASFSKSSHVRDNEEPMQITLEHRTHIIHTSGTTSEPKAVQIAARSILQVVFHAPFEPLYPTDRVAHVNNSSFDVSLFDIWAPLLRGACIVVVSKVTLLDLETLAAYIDRQGITVMATTTAILNLAASVYPRAFEKLRLCFIGGEAANISAIETIFQAGPPTQLINAYGPTECCIFCLAHRVTIADVQAGVVSIGKPIGRTVAYICDEAGRPVPDGHEGELLIGGAGVSPGYINQPDKNRASFVAIEGSDCQRFYRTGDIVRRRVSNGQIDYVGRRDHQVKVRGFRIELEAVESAIMKTGQFSEAVALKVEAGSEGAGSILVAFAVALSGTKPHAVLSAVDMLKAVLPDYMVPKIELISKMPVNSHAKVDRKYLQQLFRNRWAEQHIDMDNEDSTRGKLANLWASILGVPVPASNDNADFFLLGATSMQASLLISRIQKTFNVQVSLLTLYDNSSLIRLAGILEERILGTQESFCKESERHMWLEDSKLADSLVPPSDPPVDWCRDTEGRVFLTGATGFVGSFLLADLLRQPNVHQVGCLVRAVDPATGLRRLQNGLAKYDLWEDQFRYKLLPLCGTLEDRYLGLGPDRFEEIAHWASVIFHLGARVNYTQPYSLHRPANVQGTVNVLRLACAGRSKVLHYVSSISCFGPTGFITGTRTVMENEPLPRHLEALPYDHGYAQSQWVVENMLQRLMDNGFPIVVYRPGFITGHSQTGACNPDDFLSRLIIACGEMGSYPLLPNQRKEFVPVDYVNAVILHIASSTATAVGRVYHIVPPNRDLSLDMNDSMELVGSLAEGNESSVRGVSYQQWVQELDRQSPERLRPLQPMLTEKLYQGLTRWELYENMPVYDTTNTRQALESYPGGLKFPVLDSELMQKYIRYLQIRSASPKEENPLNGTDS", "function": "Non-canonical nonribosomal peptide synthetase; part of the lna gene cluster that mediates the biosynthesis of diastereomeric piperazines. Lna and lnb clusters encode sets of enzymes that produce overlapping sets of previously undescribed metabolites such as piperazinomycin-like metabolites or morpholine. The lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure. One primary function of the non-canonical nonribosomal peptide synthetases lnaA and lnbA consists in the reduction of L-tyrosine. The presence in the clusters of tailoring enzymes such as the oxidoreductases lnaB, lnbB, lnaE or lnbE, as well as of the cytochrome P450 monooxygenases lnaC, lnaD, or lnbC, might explain formation of various diastereomeric piperazines.", "AFDB_id": "AF-B8NTZ9-F1-model_v4" }, { "swissprot_id": "Q92357", "sequence": "MDDTNQFMVSVAKIDAGMAILLTPSFHIIEFPSVLLPNDATAGSIIDISVHHNKEEEIARETAFDDVQKEIFETYGQKLPSPPVLKLKNATQTSIVLEWDPLQLSTARLKSLCLYRNNVRVLNISNPMTTHNAKLSGLSLDTEYDFSLVLDTTAGTFPSKHITIKTLRMIDLTGIQVCVGNMVPNEMEALQKCIERIHARPIQTSVRIDTTHFICSSTGGPEYEKAKAANIPILGLDYLLKCESEGRLVNVSGFYIENRASYNANASINSVEAAQNAAPNLNATTEQPKNTAEVAQGAASAKAPQQTTQQGTQNSANAEPSSSASVPAEAPETEAEQSIDVSSDIGLRSDSSKPNEAPTSSENIKADQPENSTKQENPEEDMQIKDAEEHSNLESTPAAQQTSEVEANNHQEKPSSLPAVEQINVNEENNTPETEGLEDEKEENNTAAESLINQEETTSGEAVTKSTVESSANEEEAEPNEIIEENAVKSLLNQEGPATNEEVEKNNANSENANGLTDEKIIEAPLDTKENSDDDKPSPAAAEDIGTNGAIEEIPQVSEVLEPEKAHTTNLQLNALDKEEDLNITTVKQSSEPTADDNLIPNKEAEIIQSSDEFESVNID", "function": "Required for cell fusion, independently of fus1. Appears to have a role in transporting proteins that are involved in mating. May act as a scaffold to retain cell fusion proteins in the cisternae of the Golgi. Degraded at the onset of mating and this leads to release of cell fusion proteins.", "AFDB_id": "AF-Q92357-F1-model_v4" }, { "swissprot_id": "Q5UYP1", "sequence": "MSDDPEDRMLGWDESVFRDEHVFEIDWLPETFKHRDTQMETLKYALRPAVRGSRPLNVIARGPPGTGKTTAVQILFDELTAQTDVKTVRVNCQMDSTRYAVFSRLFAEIFDYEPPSSGISFKKLFSQITDKLVEEDEVLVVALDDVNYLFYESEASDTLYSLLRAHEAHSGAKIGVICVSSDLELDTIDALDTRVQSVFRPEEVYFNPYGQAEIADILGERADRGFNEGVVGPTVLDRVAELTEEQGGDLRVGIDLLRRAGMNAEMRASRSVETEDVEAAYDKSKYVHLSRRLRELSDSETALVEVIAAHDGQQAGDIYDAFSEQTDLGYTRYSEIINKLDQLDIIDADYTNVEGRGRSRELTLNYDADAVLERL", "function": "Involved in regulation of DNA replication.", "AFDB_id": "AF-Q5UYP1-F1-model_v4" }, { "swissprot_id": "P87219", "sequence": "MSEEIISFTNPALGPLPTKAPQLPSNVLDLFSLKGKVASVTGSSGGIGWAVAEAFAQAGADVAIWYNSKPADAKAEYLTEKYGVKAKAYKCNVTDPNDVSKVINEIEKDFGTIDIFVANAGVAWTDGPEIDVQGYDQWKKIVDCDLNGVYYCAHTVGQIFKKNKSGSLIITSSMSGTIVNIPQLQAPYNAAKAACTHLAKSLSVEWASFGARVNSISPGYILTDIADFADPEMKKKWWQLTPLGREGLPQELVGAYLYLASNASTYTTGSNIAVDGGYTCP", "function": "Catalyzes the NADP dependent reduction of L-sorbose to D-glucitol. Can also convert fructose to mannitol, but less efficiently.", "AFDB_id": "AF-P87219-F1-model_v4" }, { "swissprot_id": "P18410", "sequence": "MEPESIGDVGNHAQDDSASIVSGPRRRSTSKTSSAKNIRNSSNISPASMIFRNLLILEDDLRRQAHEQKILKWQFTLFLASMAGVGAFTFYELYFTSDYVKGLHRVILQFTLSFISITVVLFHISGQYRRTIVIPRRFFTSTNKGIRQFNVKLVKVQSTWDEKYTDSVRFVSRTIAYCNIYCLKKFLWLKDDNAIVKFWKSVTIQSQPRIGAVDVKLVLNPRAFSAEIREGWEIYRDEFWAREGARRRKQAHELRPKSE", "function": "Regulatory component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates the phosphatidic acid phosphohydrolase PAH1. Essential for the formation of a spherical nucleus and meiotic division. The NEM1-SPOo7 protein phosphatase is required for efficient mitophagy under prolonged respiration, as well as for reticulophagy and pexophagy.", "AFDB_id": "AF-P18410-F1-model_v4" }, { "swissprot_id": "Q92XP5", "sequence": "MSDRCELLVIGGGLIGSAIAWGAARKGARVTLLDEGDIAYRASRANFGLVWLQGKGLGHPDYMHWSIRAGQLWPELSTILLKETGIDIGWRGGGGLHFCLSESEMAARRALIARSSAEGAAIRIQLLDRDALHEIVPDIGPEVRGASLSDLDGEANPLLTLNALQLAFQQNGGRLVVQFAARNIRSEPARGFVVSDANGDEISGRRVVLAAGLGNNELARQVGLKLGLTPERGQIVVTDRIAPFLRYPSNAIRQTREGTVLLGSSHEDAGFSTGTDVETIARLCRIGTRVFPALRAARLIRAWGALRIMSPDGLPIYEEAPEMPGAYVVTCHSGVTLASLHALELGPALAEGHLGPAPRSMRSTRFAL", "function": "Oxidative cleavage of octopine into L-arginine and pyruvate.", "AFDB_id": "AF-Q92XP5-F1-model_v4" }, { "swissprot_id": "Q6FEY7", "sequence": "MAKVAGFRFELKQLFHLMWPILITQFAQAGLGLIDTIMAGHLSANDLAAIAVGVGLWMPVMLLFSAIMIATTPLVAEAKGARTPEHIPVIVRQSLWVAVSLGVIAMLILQLMPFLLPILGVPESLQPKAGLFLHAIGFGMPAVTMYAALRGYSEALGYPRPVTVISLLALVVLVPLNYIFMYGIGPVPHLGSAGCGFATAILQWLMLITLASYIYRAKAYQSTQVFSHWERINLTLVKRILKLGLPIGLAVFFEVSIFSTGAIVLSPLGDTLVAAHQIAMSVTSQLFMIPMSLAIALTIRVGMYYGEKNWVSMRLVQKLGLATATFFAMCTMSLIWFARPQIVAIYTQDPAVFDIALYLLLFAMAYQLMDAWQVGAAGCLRGMQDTKGPMWITLIAYWVVAFPVGTYLARVAKMGPAGVWLGLITGLSIACVLLLMRLYRNNHKLAQQS", "function": "Multidrug efflux pump.", "AFDB_id": "AF-Q6FEY7-F1-model_v4" }, { "swissprot_id": "P83179", "sequence": "DFMFGTSTASGGLAPSGVMNSLEPKGLAYYNNLLNELLKVLFTYFGDRAYAPNSPQRLSLSLSGVFHLLRGTADFYALNHYSSRDKYGLPKLLLTEDGYGDDGQLDDFEKNYLNATLQAMYLMKEQNVTSVHYTVNKCMN", "function": "Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.", "AFDB_id": "AF-P83179-F1-model_v4" }, { "swissprot_id": "Q8N8R5", "sequence": "MWGFRLLRSPPLLLLLPQLGIGNASSCSQARTMNPGGSGGARCSLSAEVRRRQCLQLSTVPGADPQRSNELLLLAAAGEGLERQDLPGDPAKEEPQPPPQHHVLYFPGDVQNYHEIMTRHPENYQWENWSLENVATILAHRFPNSYIWVIKCSRMHLHKFSCYDNFVKSNMFGAPEHNTDFGAFKHLYMLLVNAFNLSQNSLSKKSLNVWNKDSIASNCRSSPSHTTNGCQGEKVRTCEKSDESAMSFYPPSLNDASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKSIRTMYWLDGGHSGGSNTWVTYPEVLKEFAQTGIIVHTHVTPYQVRDPMRSWIGKEHKKFVQILGDLGMQVTSQIHFTKEAPSIENHFRVHEVF", "function": "May play a role in the respiratory chain.", "AFDB_id": "AF-Q8N8R5-F1-model_v4" }, { "swissprot_id": "O25551", "sequence": "MMANILGAGVYSDIFFVAFKLPNLFRRIFAEGSFSQSFLPSFIRSSIKGSFASLVGLIFCIVLFMWCLLVALNPLWLAKLLAYGFDEETLKLCAPIVAINFWYLLLVFITTFLGALLQYKHSFFASAYSASLLNVCMILALLISKEKTHLEALYYLSYGVLLGGVAQILLHFYPLVKLGLLNLLWKGFLSFKTKNAAKKKYRSKRIKRDLKGFFKQFLPSVLGNSSAQIASFLDTTIASFLASGSVSYLYYANRVFQLPLALFAIAISTALFPSIAIALKNNQQDLILQRLQKAWFFLVGVLLLCSIGGIMLSKEITELLFERGQFSPKDTLITSQVFSLYLLGLLPFGLTKLFSLWLYAKLEQKKAAKISLISLFLGLAASLSLMPLLGVLGLALANSLSGLFLFVLTIKAFGFQLFLGIIKNLKSWLVILFLACVEILLLLAFKSWVTHLYLFYYFQGF", "function": "Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.", "AFDB_id": "AF-O25551-F1-model_v4" }, { "swissprot_id": "B9JYP8", "sequence": "MTASLLKAELHCHIEGAAPPALVAAQAEKYGIDASSFIRNGSYVWEDFTSFIAAYDFVASVFRTEEDFAALAEAYLIELAGVNTIYSELFVSPDHGEAVGLSAEAYIEGLAEGIVAARIKTGIECRMVIIGERHLGPENVLRRAKWLADYHHPLITGFNMAGEERMNRVADYAPAFDIAREAGYGITIHAGELCGAFSVRDALDLVRPSRIGHGVRAIEDADLVQRLADEGVVLEVCPASNIALKVFEDYASHPMRDLTDAGVRVCINSDDPPFFATSLANDYAIAASMGFSDVEIDAMTRTAIEAAFVDEATRQNLLQRLQAAGSGDEAAI", "function": "Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.", "AFDB_id": "AF-B9JYP8-F1-model_v4" }, { "swissprot_id": "Q9UQ84", "sequence": "MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAYEDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTAMPAHSRSHSWDDKTCQKSANVSSIWHRNYSPRPESGTVSDAPQLKENPSTVGVERVISTKGLNLPRKSSIVKRPRSAELSEDDLLSQYSLSFTKKTKKNSSEGNKSLSFSEVFVPDLVNGPTNKKSVSTPPRTRNKFATFLQRKNEESGAVVVPGTRSRFFCSSDSTDCVSNKVSIQPLDETAVTDKENNLHESEYGDQEGKRLVDTDVARNSSDDIPNNHIPGDHIPDKATVFTDEESYSFESSKFTRTISPPTLGTLRSCFSWSGGLGDFSRTPSPSPSTALQQFRRKSDSPTSLPENNMSDVSQLKSEESSDDESHPLREEACSSQSQESGEFSLQSSNASKLSQCSSKDSDSEESDCNIKLLDSQSDQTSKLRLSHFSKKDTPLRNKVPGLYKSSSADSLSTTKIKPLGPARASGLSKKPASIQKRKHHNAENKPGLQIKLNELWKNFGFKKDSEKLPPCKKPLSPVRDNIQLTPEAEEDIFNKPECGRVQRAIFQ", "function": "5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.", "AFDB_id": "AF-Q9UQ84-F1-model_v4" }, { "swissprot_id": "B1AJ69", "sequence": "MILNKEKIKNYAAYLYIKVAYDQAHSKMAHTVYFTNFYRSSKPLFLDEEDPINPCFQTISMGGGYVSGEIYRSDFEINDDARCIITTQSSAKAYKTVDGKTSEQHTNITLGKNSILEYISDNVIVYEDGKFAQFNNFKMDSSATLIYTECFGPGWSPHGSAYQYEKMYLNTKIYYDDKLVLFDNLKFQPRKNDESAFGIMDGYHYCGTMIVINQQVIEDDVIKIRDLVKEKYPDMDMIFGVSRMDIPGLGLRVLANTYYHVEKINAVAHDYFRRKLFNKKPLILRKP", "function": "Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.", "AFDB_id": "AF-B1AJ69-F1-model_v4" }, { "swissprot_id": "P57299", "sequence": "MTYIVALTGGISSGKTTISNGFKKIGINVIDTDIIAKNIIEKNLQVSFSIKRKFGKKILNIDNSINRLLLRQYVFNNHHHRLWLENLLHPKIYQESKHQIKMTQSNWCLWVVPLLVEKKLEKKAHRILLIDTPVKEQIKRTVRRDKISFLEAKKIIALQSSRKTRISLSDDIIFNKKNFKKINLYIYYFNLLYSHLSRIYNKNKTINIKKNFLTKFY", "function": "Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.", "AFDB_id": "AF-P57299-F1-model_v4" }, { "swissprot_id": "Q05562", "sequence": "MTEETPGFEEKPDVPSGATPDDAEPQAASEEGAAPAGDASENAGLVAQLDQVRTALNERTADLQRLQAEYQNYRRRVERDRVAVKEVAVANLLSELLPVLDDVGRAREHGELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAEPQPGAQTVKPAEDAAEAQDSSGAEDDAGTKESGGPDEG", "function": "Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.", "AFDB_id": "AF-Q05562-F1-model_v4" }, { "swissprot_id": "Q2SZV9", "sequence": "MTIGLSCNALKYGGGLERYAIDLARGLADAGVRPLVFARSFDSSVPEYQCVEPRRINVSFLPGKCRDAWFSWRLRAARRAAPVDVLIGCNRVDSSDIAICGGTHLGFLDAIGRMPTFSDRRQIALERRQYARARFVVAHSMLMRDELRRFYGLSDDKIRVLFPPVDAARFTPVDAVRRAELRTRFGFADDEVVLLFPSSSHERKGLPLIEAILRDAGPRVVVAVAGRPPERTSERLRYVGYVKDIEDGYRAADFTILASKYEPFGLVGVESVMCGTPVILPSNIGCCDAIAPSAKLVFAPGDAAGLRGMLDEAVRRVRAGAVRVESGAAARAAIQYDPSVARHVAQLLDLAAEAASDRRNGGR", "function": "Probably a transglycosylase. Probably involved in synthesis of the outer membrane receptor for a cellular contact-dependent growth inhibition (CDI) system.", "AFDB_id": "AF-Q2SZV9-F1-model_v4" }, { "swissprot_id": "A5PJX4", "sequence": "MAEASSLERQSPGAASCLPHSLCPGEPNLQTTAVVSMGSADHQFHLAEILSQNYGVREEHEGAAPGPEKPEEELEKDFVSQSSDMPLDELLALYGYETSDPISERESEGSDTAAHLPDMTLDKDQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPSQSGSCFLADADKEPGSSSSSDAEEDPLPANKCKKEIMVGPQFQADLSNLHSNRHGEKIYENEDQLLWDPNILPEREVEEFLYRAVKRRWHEMAGSQLPEGEAVKDSEQALYELVKCNFNAEEALRRLRFNVKVIRDGLCAWSEEERRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFSQQTRLGRRKYGPSGNTDADQDLEGSDPDGPGRPRSSPPLPLPAAAHGPGPEHDRLAQMHTEPLSMGSSMSRSLGEPGEALDVPPSSEPGPRLFPPLDEPSALPSSRRPPALAEPAFFPPATAAPEPGASPRLAVDLTLPEELPLVSSHEDTDGEPEETVGPPQVALSVAEFGLIGIGDVNPFLASHPACPASGLHSEPLSHCNVMTC", "function": "Transcriptional repressor.", "AFDB_id": "AF-A5PJX4-F1-model_v4" }, { "swissprot_id": "Q59QC7", "sequence": "MMMTVKQESPNSTLNTSEFSSDENLKTNNSEPPKKVSKSSTGKRKYHQKSRNGCSTCKKRRVKCDEQRPVCGNCTKLKLDCGYLHEPLENILNTKKDIANNEPPSKKRKRKVSTVSAASDSESTTQQATPSLTPSPNHSQDIKTQPVIPPTNPLSALSSGLLSAGNLNNLNVAHLVNNLSGLGDLSNLASLGNLASLSNLASLAQLPIDLSNLGSLLDSPAASNIAASFLGSAAATTVPPTTNSEFKESNQRKSQTQMPPQPTVPITSMGAATTTSSHQQANMPSRSKPQPETLQSSIPATTSGSPGMSYPGCPSNSDPFGRSSDKSLPNISPNMSIPANPLSDPLTQGMRSNLNMLDLKLMFHYTSVVANTITGAGISDTNIWNCDIPKLAFEHPFLMHSILAFSATHLSRTEKGLDQCVTCHRGDALRLLREAVLNINADNTDALVASALILIMDSLANASFPSSTSPKSLPASAWIFHVKGAATILTAVWPLTEASRFYKFISVDLGDLGDIINQGVNMNKSKGIDRENSAYYTDLECHDADIADLFPVLLDSPYLITLAYLNKLHKERYKSDFILRIFAFPALLDKQFMGLLMSGDVKAMRIMRSYYKLLRSFTTEMKDKVWFLEGVSQVLPVNVEEYAGGAGGMHMMMDFLGGGPAIVDDNEIDAEITKFDPSGTLTNKLIDTDNLPSVLTSNLDLMQGDNGFMNMK", "function": "Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping.", "AFDB_id": "AF-Q59QC7-F1-model_v4" }, { "swissprot_id": "C1DKJ6", "sequence": "MIVELDCGNSFIKWRIIDAFSRVLSSGVVESIEELVHALDEARTSHEFAHCRMVSVRSDDEVARLESVLAQRFGLRVSAVRPASCLAGVRNGYLNHERLGLDRWMAVVAAYRLSAGACLVLDLGTAVTADFVDADGEHRGGFICPGLPLLRRQLREHTRRIHYDAVAANDLTGGSFAPGRSTAEAVERGCVLMLRGFVASQLELAKEYWGDRFEIFLTGGDASLVADVLPRAKVVPDLIFTGLAIACPIPS", "function": "Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.", "AFDB_id": "AF-C1DKJ6-F1-model_v4" }, { "swissprot_id": "P31502", "sequence": "MKRQLTVAVAGAAILAAGISGCSGGNKSGTSASSSANSSGTTRRLAPGAAGTKVTIDGKDQNVSGSVVCTNAGGTINIAIGGAATGIAAVLSDGNPPQVKSVGLGNVNGVTLGYTSGTGQGNATASKDGNSYKISGTATGVDMANPMQPVNKPFEINVTCNS", "function": "Might be involved in ligand transport. A host TLR2 agonist, modifies host gene expression in response to pathogen.", "AFDB_id": "AF-P31502-F1-model_v4" }, { "swissprot_id": "Q5JNT6", "sequence": "MASLQSGGDAAANGVDADVDGAASPPSAKRPRAGAGAAAITDAEVRAEFAHHDRAVARLNNGTFGCCPASVLAARARWQRLFLSQPDAFYFHHLQPGLARSRAAVAAAVGAGDASEVSLVDNVTTAAAIIMQHVAWSFAEGDFARGDVVLMFLYTYCSIKNSIHAYVARAGATVVEVPLPFPVSSPDAIVAEFRAALAVARDGGRRRVRLAVIDHITAMPTVLIPVKELVAICREEGVDKVFVDAAHAVGQVPVDVRDIGADFYASNLHKWFFCPSAVAFIHTRKDDPVSSKLHHPVVSSEYGNGLPMESAWIGVRDYSAQLVVPDVVDFVNRFDGGVEGIRRRNHDKVVEMGTMLAAAWGTFLGTPPEMCGSMLMVGLPGSLGVGSEDDAVGLRTMLRKQFKVEVPLYYNSKAAAADAPPEMVKDGNGDPVTGYVRISHQVYNVREEYEALRDAVAKLVADGFTCRKLRPPEKEETLA", "function": "Catalyzes the production of hydrogen sulfide (H2S) from cysteine.", "AFDB_id": "AF-Q5JNT6-F1-model_v4" }, { "swissprot_id": "F4JCU0", "sequence": "MDPSRYGRQQEWDNNSAPEGYGTQHDPNHRFGVSYDDGYPDERLMRDDVYNYPPGHNTLGDLPQSRKRNYEENYPSELRRQEKPYIDSNYAADYYHDSEAGSRNGHYRDHEHERSSRYDGCDDYSCNDNNYRSKNYHHSRDDGREKDYDYTRRSYDSEYERASVRDGSRKSRDPQDRERNSRDREWDSRDREWDKRCYSRERDESPHKRYEKSRSRSTGRGEFSRSRSPRGRSHGRSYREDSYEGDHWNESERRREYEDRHNQDHFSATPSATVVVKGLSMKSTEEDLYQILAEWGPLHHVRVIREQNSGISRGFAFIDFPTVDAARTMMDRIEHDGIVLDGRKLMFHYSQPTGRAGVSRRQEHASRRSYGGSRNMIVPTDWICTICGCINFARRTSCFQCNEPKTKDSPSADVGLSNSAAGKRISETGPTHVLVVRGLDEDADEEMLRYEFSKHAPIKDLRLVRDKFTHVSRGFAFVHFYSVEDATKALEATNRTALERNGKILRVAYAKSVHGSGTGISAPSHSNNLAAAAIEAATFSQQYDGVGWAPKEYNTGEKQNTGGQAQGVGEIESQKGTSAPQSGYVWDEASGYYYDAASGYYYDGNSGLYYDSNSGLWYSYDQQTQQYVPCPDQNNESKVTENQPDSAKKEKSSQQKVIISAATTPNVEKVLSLPDAVQAAAAAAIASEKREKERVKEIKLASKTSLLASKKKMSNVLTMWKQRSHETQIQRPSPSLGDNPPTVSAEARSSFSTGQSMGKLKSDVIIAKERSTSNHGVSALTTAESSSSSTTGGTLMGVMRGSFGGTLGGASSSASVQMPPILPSASPASVSVSGSGRRRFSETPTAGPTHREQPQTSYRDRAAERRNLYGSSTSSGNDVIDSSEDLMGLRKGSSDPTPFPPGVGGRGITTSTEVSSFDVITEERAIDESNVGNRMLRNMGWHEGSGLGKDGSGMKEPVQAQGVDRRAGLGSQQKKVDAEFEVQPGDTYRTLLHKKALARFRDMSDNN", "function": "Splicing factor that controls alternative splicing of the developmental regulator ABI3. Reduces splicing of a cryptic intron in ABI3, leading to a decreased in ABI3-beta transcript. Regulates the splicing of the receptor-like kinase SNC4/LRKL-2.6.", "AFDB_id": "AF-F4JCU0-F1-model_v4" }, { "swissprot_id": "A5EYU0", "sequence": "MKKIAWSLGILVTIGALCAIVWPSWYPSRPLVTTPSQADIQADQSSPRDLLEYFLSGLGETSLPVIQQQVQRYEQENQGLLIDSSLFAQYVQYKAALSELTLPQASGGLSTQEWWQLHQSLLDLQARYFSAEQQALFAEENRLRELAIEKRRIYEQYGQSEEAQRAWQALLLDQPDFIQRSEATAQLLPQLTQAGQGDTQQRYLARVALVGEQGAQRLAELDDSRATFEQQFQDYYQARAAILVRNELSASEQQTQIQQLREQHFAPEQWRRIDALERLKDNGE", "function": "May be involved in the folding of the extracellular lipase during its passage through the periplasm.", "AFDB_id": "AF-A5EYU0-F1-model_v4" }, { "swissprot_id": "Q8HTL6", "sequence": "MLNISTNMMINQTLNFDSNQESQKNKTERISKTKLTRELITKTDHDIYVDDISFLQREDNVNVSQIDLTARGVLNPEDQGVLHKSTEFGVFNKNKTGLPASVDLKIKQNSFFSVKQPDFNKYLISDFVEIQRNSFFTLLEKGIIEEFSKRNPITNSKKTMEIFFYPDYYQLTPPEYSPSQAIIKSKSYTSKLYIPVQLTDKSKNIIKLKWVYIGDIPLMTKRGHFILNGCARVIVNQMVRSPGIYYQKKIYENFSNKWSEKPENTFTRYFADLICNRGTWLRIEMDKYNKIWAQMKRVPKIPIMWFLIAVGLTDKIVLKTVMDSKILLYNLDEDPLNPRKKPLPYVKTPPAAWSAIYNIVFAKKIKAQEKAKKMLELTEGNPSSKSQTKNKTSASKKSKTLNVANTKGKTPAENIKTLSELIDLEKALFLKSEQGRKWIFNKFMNPRTYDLGKVGRVNFNRKLKLSISQDITTLTPQDLLAATNNLILVSKGLRELDDIDHLKNRRVRTSGELIQIQIGVGLVRLEKTIREKMTYASGLSSLPSQKFAFRSSKQRNQSPVGDAENATQLTIGNLINTKPFNGALREFFGTSPLSQFMDQINPLAELTHKRRLSSMGPGGVTRDSATLAIRGIHPSHYGRICPVETPEGKNTGLVNSLTAYARVNAAGYIETPFYRVYKGQVQKKTGLYFFSAKQEEKIKLGAPDLYTSEIGFLPKASIPVRIVEDFTKISRNEIQYVGVAPIQMISIATSLIPFFEHDDANRALMGSNMQRQAVPILKPQRPIVGTGLEARAVSDSGHVITAKSSGIVMYTSSKEIIIYSLQ", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "AFDB_id": "AF-Q8HTL6-F1-model_v4" }, { "swissprot_id": "Q6KIH8", "sequence": "MIINYKFSDFYFDKKLSGKEVEFSIQIQKREASSDKNLQSKNLIIDAINVQRDFSEKNKSSDNLEILNKQIEDKNDLIINLEKKVFDLTLENKKNIDDFNEKAKSFAKKAQEELDKYKLELKSFLENEFEEKKKFSFQKLFENIINPLNNFRLAIDAGSKQENSSIKSYVQGFEMLLNQTINILESYGLIIIRPEIGDTFNPEVHNAVELREEGTPNRILKINSLGYQFHERVLKPASVIVSK", "function": "Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.", "AFDB_id": "AF-Q6KIH8-F1-model_v4" }, { "swissprot_id": "Q75EN9", "sequence": "MDFIAVYNPAVYAKEADSEAWRQLLLYHSFKEDAEEPTPQNEKLSLIGMIQGIWQFAHNFSEPETRGSVRYVDTQLERRRVIAVEVEDGHFMAFGVEDGKRYGCEYYVRELLQSYHVFRLHCGSMSEFADRGELTDRLNEHVVGYWQALKLVPEAIYASTLASVCWHDGYKVSELELRDRAWESYIKNEILLDSESFLGLKDMCIYKLPRDGRRSAAEYGLLRSFAPEFLSLPELSNWVYHLDRLFETALSSHVLAGHVRLSIGGDEQEEEGELRHDSQPASDVGARMWRNVTMPISMTYDTMSEVGNLTGINTLMSGLNSLTSGFSSMTSRLVRRADRQNSDTASLSLHVDHGFLISPLALEALPESYRYRRFQLRFSTDEPQWYRLLFWYYKDYLCIFIFHENFDKIWDPDYLQAIDAKLYDAMLQLEGSVVTEDNKPGRFAYGVFNKTTKRIECSLPLLRFSDKRSDEKSRQPLKMVVAGIDETLQFLTAGTFATNMATSRTNDEHMGPSATNTLRMPEPTDAPSSSWTLDITKLNLFQGLNENLRLEKMADTDSGTFLDSLSSEKLLQLNVELCRLYTGIRRSEYNKAGIQEEQLLRLNNGILFYISTSPTEDVLILKNWFMDDKYTKAENKRSTSASLLHSLGGDVRRWWNARTNREQ", "function": "In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.", "AFDB_id": "AF-Q75EN9-F1-model_v4" }, { "swissprot_id": "Q8NCA9", "sequence": "MAAARPEAQSRSSPTPESRSQEPLDLVLVPDDCRPGTPPSDLIEIQVVKVTDTTLVPEPPEPGSFHCALCPAAFRLVSELLFHEHGHLAGAEGGGQGGDPSRCHVCGHSCPGPASLRAHYSLHTGERPYRCALCPRAFKALAPLLRHQHRHGVEPGTSRRPPDTAAVAEQRPGVAPERAEVVMAAAAAGAAVGKPFACRFCAKPFRRSSDMRDHERVHTGERPYHCGICGKGFTQSSVLSGHARIHTGERPFRCTLCDRTFNNSSNFRKHQRTHFHGPGPGLGDSGGQLGSSAAEGSGSGCGVGDPAEEGRGETAKVKVEADQ", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q8NCA9-F1-model_v4" }, { "swissprot_id": "J7RET5", "sequence": "MAAVQVRRRGRALALALWAGFALSVGGGVRARDGLATPPAFEGQAAPAVSWPCPPPADRLDDLALLEAIDLALCHSPALRQGWARIKARSAEVGLARAPYYPSVALSAGRSAQRRSTGLGEDGVRNNVMAVTLAWRLFDSGARSAALRAAQAQLDEAAQAYGAVLQDKLAEVVGAYYEAATARQALHTAVEDTEIARRSASIAARRARAGLDSHGDVLHAQAALERARLAQAQAEGAQARALAGLAQVLGVDPATPIVLAPGPLAPQRIEDRELAQWLRDARQRHPAIKAAQAGLAAATAQVDVARATDMPTVDLSLGHYRNSSENVSVFAGSSRSVSASLNLRIPLFDGFARRHRIQGARAEVQRQEALLDQARLATGAAVARAYADLRAARASHEASLRWLKAARAAYESDLRRYEAGVGGVAELLRAQSDWLSARQRHVLYAAQLRTRALALLAAAGELGRSTIDGDPPKE", "function": "CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).", "AFDB_id": "AF-J7RET5-F1-model_v4" }, { "swissprot_id": "Q41771", "sequence": "MPYPHPYPWQSSRRRRRRRGRDGAPRQPQARRVVERAAAGPGHATTTQQPDNVSSAKVFQTSRVETESEIAKWPGKPQDLEDEHQAEEAELQPLIDQVRAMLRSMNDGDTSASAYDTAWVAMVPKVGGDGGAQPQFPATVRWIVDHQLPDGSWGDSALFSAYDRMINTLACVVALTKWSLEPARCEAGLSFLHENMWRLAEEEAESMPIGFEIAFPSLIQTARDLGVVDFPYGHPALQSIYANREVKLKRIPRDMMHRVPTSILHSLEGMPDLDWPRLLNLQSCDGSFLFSPSATAYALMQTGDKKCFEYIDRIVKKFNGGVPNVYPVDLFEHIWVVDRLERLGISRYFQREIEQCMDYVNRHWTEDGICWARKSNVKDVDDTAMAFRLLRLHGYNVSPSVFKNFEKDGEFFCFVGQSTQAVTGMYNLNRASQISFQGEDVLHRARVFSYEFLRQREEQGMIRDKWIVAKDLPGEVQYTLDFPWYASLPRVEARTYLDQYGGKDDVWIGKTLYRMPLVNNDTYLELAIRDFNHCQALHQLECNGLQTWYKDNCLDAFGVEPQDVLRSYFLAAACIFEPSRAAERLAWARTSMIANAISTHLRDISEDKKRLECFVHCLYEENDVSWLKRNPNDVILERALRRLINLLAQEALPIHEGQRFIHSLLSLAWTEWMLQKANKEENKYHKCSGIEPQYMVHDRQTYLLLVQVIEICAGRIGEAVSMINNKDNDWFIQLTCATCDSLNHRMLLSQDTMKNEARINWIEKEIELNMQELAQSLLLRCDEKTSNKKTKKTLWDVLRSLYYATHSPQHMIDRHVSRVIFEPV", "function": "Involved in giberellin biosynthesis (Probable). Catalyzes the conversion of geranylgeranyl diphosphate to the gibberellin precursor ent-copalyl diphosphate (Probable).", "AFDB_id": "AF-Q41771-F1-model_v4" }, { "swissprot_id": "P91623", "sequence": "MDMTSTAEAAARSWYDSPRLGGGGSSGGGNGGGVSPQTNGLGSAGSSLAHSHHSLSSGASSAGSSVGVGSALGGGGGSGLDTSDMSAFYALESNGHHRRYYPSYHQHTSRMPSTHASPQVCRPHFHTPLSPWLTSEHKSFAPASAWSMGQFACPQEPQVEHKLGQMGQSHQTTAAGQHSFPFPPTPPKDSTPDSVQTGPSEYQAVMNAFMHQQATGSTSLTDASCALDIKPSIQNGSASGSSGSGTTHTSTPKQREEGRECVNCGATSTPLWRRDGTGHYLCNACGLYYKMNGQNRPLIKPKRRLTLQSLQSAAKRAGTSCANCKTTTTTLWRRNASGEPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKLSSKSKKKKGLGGGCLPIGGHLGMGDFKPLDPSKGFGGGFSASMAQHGHLSSGLHPAHAHMHGSWYTGGMGALGASSGLQGGFSTAGSLSGAVVPHSQPYHLGLSSMGTWRTDYT", "function": "Transcription factor that is vital to the development of multiple organ systems. Binds to the core consensus sequence 5'-WGATAR-3'.", "AFDB_id": "AF-P91623-F1-model_v4" }, { "swissprot_id": "B8DN15", "sequence": "MSTYPLRDAVAAIATPLADALGIALWGIEIIDGGRMVLRVYVDAKPGMPVPADTAEATESATPEGVALEGSTPEGVTIDQCARLSRQLGLALDVEDVVRDAYVLEVSSPGLERPFFEIAQVVPYVGRTIELTLAVPHPEWPGRRKFRADIVRVEGDTLTFLPDTAPRPDEDPAPISVAWDDVKKAHLIHVFPDTTRPQPGGKTGQRKKAQPKKPARGGAPHDDTTD", "function": "Required for maturation of 30S ribosomal subunits.", "AFDB_id": "AF-B8DN15-F1-model_v4" }, { "swissprot_id": "P0A3G6", "sequence": "MFDKKLLESSELYDKRYRNFSTLIILPLFILLVGGVIFTFFAHKELTVISTGSIEPTKIVAKIQSTNANPIIENNLKEGEAVKENSLLLKYNGTPEQTQLSELLTQKKQALDKKVQLDLLQRSLTNEKNEFPTADSFGYEKSFENYEAQVKSLEATIQKSNQAVEDQNKSTESQKQAIQNQVATLQQAIQNYSEIENAVSSGGGVSQDNPYLSQYNSYQAQQATLEADLKNQKNPDETAKQAAKSQEESLKSQFLSGLASSKDSLKSQIQSFNVQESSLTGSNAYDNSQSSQILTLKSQALSASNKEMTDLNSTLTDLETKISLQKQDDQYSQVFAEQAGVLHVLPDILGMKKIPIGTPIAEIYPLLKSETQVNLTSYIPSTQISGMKVGQKVRFTVQQNLPQPEILTGIINQIDSAPTAFKEGNAYKVSATTTINAKDLPNIRYGLQGKTVTIIGKKTYFNYFLDKIMGRGNQ", "function": "Involved in the secretion of lactococcin A.", "AFDB_id": "AF-P0A3G6-F1-model_v4" }, { "swissprot_id": "D5E3H2", "sequence": "MKKVTVDDFSSPENMHDVIGFYKKLTEHQEPLIRLDDYYGLGPAWVALRHDDVVTILKNPRFLKDVRKFTPLQDKKDSIDDSTSASKLFEWMMNMPNMLTVDPPDHTRLRRLASKAFTPRMIENLRPRIQQITNELLDSVEGKRNMDLVADFSFPLPIIVISEMLGIPPLDQKRFRDWTDKLIKAAMDPSQGAVVMETLKEFIDYIKKMLVEKRNHPDDDVMSALLQAHEQEDKLSENELLSTIWLLITAGHETTAHLISNGVLALLKHPEQMRLLRDNPSLLPSAVEELLRYAGPVMIGGRFAGEDIIMHGKMIPKGEMVLFSLVAANIDSQKFSYPEGLDITREENEHLTFGKGIHHCLGAPLARMEAHIAFGTLLQRFPDLRLAIESEQLVYNNSTLRSLKSLPVIF", "function": "Cytochrome P450 whose physiological substrate is unknown. In vitro, is able to catalyze the selective hydroxylation of mevastatin to pravastatin, the widely used therapeutic agent for hypercholesterolemia.", "AFDB_id": "AF-D5E3H2-F1-model_v4" }, { "swissprot_id": "A0A0H2URB1", "sequence": "MNKTIVLAGDRNYTRQLETTIKSILYHNRDVKIYILNQDIMPDWFRKPRKIARMLGSEIIDVKLPEQTVFQDWEKQDHISSITYARYFIADYIQEDKVLYLDSDLIVNTSLEKLFSICLEEKSLAAVKDTDGITFNAGVLLINNKKWRQEKLKERLIEQSIVTMKEVEEGRFEHFNGDQTIFNQVLQDDWLELGRAYNLQVGHDIVALYNNWQEHLAFNDKPVVIHFTTYRKPWTTLTANRYRDLWWEFHDLEWSQILQHHMGEFELISPLDKEFSCLTLTNSQDLEGIEELVTALPEVVFHIAAWTDMGDKLKKLAVYNNVRLHPQIVPPVLDKLKKSTNLYLDINHGSADENFLKSLQEQEKTLLAFQSTQHGELGQIVFENGKVSFMIDTIKDFKKNGHLTCFRQLPSLTCLTFTASQYIEQLDYLAGQLPNVVFQIAAWTAMGPKLYDLSNRYPNIQLYPAISRDKLDELKEKMDAYLDINLLTSTSDIVAEMAHLSKPILAFYKSQNGNNGQRLYSSEHPERMLADLQKLITKDMLEKPLDIIQVKGIDETLDYIIEHNSSLVRFGDGEINMLAGHSIPYQDYDEELVSIMRDIIGQESREDLVVCLPDAFTDRFRFTSWAIPFWKDHMDHYMDFYRELCSDSWYGSTFVSRPYIDFEDKSQAKAQFEKLKSIWENRDLLIVEGATSRSGVGNDLFDEANSIKRIICPSHSAFSRVHELEQEIEKYAGGRLILCMLGPTAKVLSYNLCQMGYQVLDVGHIDSEYEWMKMGAKTKVKFSHKHTAEHNFDQDIEFIDDETYNSQIVARILN", "function": "Also catalyzes the fourth step in glycosylation of PsrP in this bacteria. Can transfer the sugar from both UDP-glucose and UDP-galactose to the terminal sugar moiety of PsrP-GlcNAc-Glc-Glc and PsrP-GlcNAc-Glc-Gal; the C-terminal GT-D domain is also sufficient for this reaction in vitro (using truncated substrates with glycosylated PsrP SSR1). The N-terminal GT-D domain can transfer galactose from UDP-galactose to PsrP-GlcNAc-Glc-Gal or PsrP-GlcNAc-Glc-Glc in the fourth step.", "AFDB_id": "AF-A0A0H2URB1-F1-model_v4" }, { "swissprot_id": "Q9C009", "sequence": "MKLEVFVPRAAHGDKQGSDLEGAGGSDAPSPLSAAGDDSLGSDGDCAANSPAAGGGARDTQGDGEQSAGGGPGAEEAIPAAAAAAVVAEGAEAGAAGPGAGGAGSGEGARSKPYTRRPKPPYSYIALIAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRRKRLSHRAPVPAPGLRPEEAPGLPAAPPPAPAAPASPRMRSPARQEERASPAGKFSSSFAIDSILRKPFRSRRLRDTAPGTTLQWGAAPCPPLPAFPALLPAAPCRALLPLCAYGAGEPARLGAREAEVPPTAPPLLLAPLPAAAPAKPLRGPAAGGAHLYCPLRLPAALQAASVRRPGPHLPYPVETLLA", "function": "Plays a role in hair follicle differentiation.", "AFDB_id": "AF-Q9C009-F1-model_v4" }, { "swissprot_id": "Q03424", "sequence": "MRRTTRARTGLSALLLAASLGLGAAPAGADAPQRPAPTPASDSAAALHALDAAVERTLGDDSAGTYVDAGTGELVVTVTTEAAAAKVRAAGATPRRVQRGAAELDAAMAALEARAKIPGTSWGLDPRTNRIAVEADSSVSARDLARLRKVAASLDGAVSVTRVPGVFQREVAGGDAIYGGGSRCSAAFNVTKNGVRYFLTAGHCTNLSSTWSSTSGGTSIGVREGTSFPTNDYGIVRYTTTTNVDGRVNLYNGGYQDIASAADAVVGQAIKKSGSTTKVTSGTVSAVNVTVNYSDGPVYGMVRTTACSAGGDSGGAHFAGSVALGIHSGSSGCTGTNGSAIHQPVREALSAYGVNVY", "function": "Serine protease that preferentially cleaves peptide bonds on the C-terminal side of aspartate and glutamate with a 10-fold higher reactivity for a glutamyl bond than an aspartyl bond.", "AFDB_id": "AF-Q03424-F1-model_v4" }, { "swissprot_id": "Q9C8I6", "sequence": "MAFSSCFLLVLLQIFSALLLCLAQDQSGFISLDCGSPRETSFREKTTNITYISDANFINTGVGGSIKQGYRTQFQQQTWNLRSFPQGIRNCYTLNLTIGDEYLIRANFLHGGYDDKPSTQFELYLGPNLWSTVTTTNETEASIFEMIHILTTDRLQICLVKTGNATPFISALELRKLMNTTYLTRQGSLQTFIRADVGATVNQGYRYGIDVFDRVWTPYNFGNWSQISTNQSVNINNDYQPPEIAMVTASVPTDPDAAMNISLVGVERTVQFYVFMHFAEIQELKSNDTREFNIMYNNKHIYGPFRPLNFTTSSVFTPTEVVADANGQYIFSLQRTGNSTLPPLLNAMEIYSVNLLPQQETDRKEVDAMMNIKSAYGVNKIDWEGDPCVPLDYKWSGVNCTYVDNETPKIISLDLSTSGLTGEILEFISDLTSLEVLDLSNNSLTGSVPEFLANMETLKLINLSGNELNGSIPATLLDKERRGSITLSIEGNTGLCSSTSCATTKKKKKNTVIAPVAASLVSVFLIGAGIVTFLILKRKKRTKLGLNPNSGTGTTPLHSRSHHGFEPPVIAKNRKLTYIDVVKITNNFERVLGRGGFGVVYYGVLNNEPVAVKMLTESTALGYKQFKAEVELLLRVHHKDLTCLVGYCEEGDKMSLIYEFMANGDLKEHLSGKRGPSILTWEGRLRIAAESAQGLEYLHNGCKPQIVHRDIKTTNILLNEKFQAKLADFGLSRSFPLGTETHVSTIVAGTPGYLDPEYYRTNWLTEKSDVFSFGVVLLELVTNQPVIDMKREKSHIAEWVGLMLSRGDINSIVDPKLQGDFDPNTIWKVVETAMTCLNPSSSRRPTMTQVVMDLKECLNMEMARNMGSRMTDSTNDSSIELSMNFTTELNPGAR", "function": "Regulates negatively the abscisic acid (ABA) signaling pathway. Required for full susceptibility to filamentous (hemi)biotrophic oomycetes (e.g. H.arabidopsidis and P.parasitica) and fungal (e.g. E.cruciferarum) pathogens, probably by triggering the repression of ABA-sensitive COLD REGULATED and RESISTANCE TO DESICCATION genes during infection, but independently of immune responses. Involved in BAK1-dependent and BAK1-independent microbe-associated molecular patterns (MAMPs)-triggered immunity (PTI) leading to defense responses, including callose deposition and MAPK cascade activation, toward pathogenic bacteria (e.g. P.syringae). Required for chitin-mediated PTI.", "AFDB_id": "AF-Q9C8I6-F1-model_v4" }, { "swissprot_id": "P25026", "sequence": "MPYVTTKDNVEIFYKDWGPKDAQPIVFHHGWPLSGDDWDAQMLFFVQKGYRVIAHDRRGHGRSAQVSDGHDMDHYAADAFAVVEALDLRNAVHIGHSTGGGEVARYVANDGQPAGRVAKAVLVSAVPPLMLKTESNPEGLPIEVFDGFRKALADNRAQFFLDVPTGPFYGFNRAGATVHQGVIRNWWRQGMEGSAKAHYDGIKAFSETDQTEDLKSITVPTLVLHGEDDQIVPIADAALKSIKLLQNGTLKTYPGYSHGMLTVNADVLNADLLAFVQA", "function": "Chlorinates and brominates suitable organic compounds. Involved in the biosynthesis of the antibiotic pyrrolnitrin.", "AFDB_id": "AF-P25026-F1-model_v4" }, { "swissprot_id": "Q6P0I6", "sequence": "MAASRKGKAVKAVKQEDLRRLMQETRRDSGRQKRVESPFARYSGAGQLMCALCDAPVKNALLWQTHVLGKQHKDKLQELKSRTAPAHTPAPAHTPAHTPAAASSSSSTLKRAAEPPPAPGKRAKLQTGAGAGLGLLAGHYDDDDDDEGGAGERKTAPPTDSALPADFFDSGPAPAPPISHSGSVSKAEQQESQEPPENRPESLPEGFFDDPVRDAQVRQVDTPKDQLEREWEEFQKEMRQVNSASDAIVAEDDEEGRLERQMDEIEEQMQCLRRVEELRAKQETARSRRRSQRREEEPMQEEEPLEEEEELMHILTQDWRAKGALA", "function": "May act as an important regulator of the cell cycle that participates in the maintenance of genome integrity.", "AFDB_id": "AF-Q6P0I6-F1-model_v4" }, { "swissprot_id": "Q8R1F1", "sequence": "MGDVLSTHLDDARRQHIAEKTEKILTEFLRFYEDQYGVSLFNSMRHEIEGTGPPQAQLLWRKVPLDERIIFSGNLFQYQEDNKKWRNRFSLVPHNYGLVLYENKVAYERQIPPRAVINSAGYKVLTSVDQYLELVGNSLPGTTSKSGSTPILKCPTQFPLILWHPYARHYYFCMMTEAEQDKWQAVLQDCVRHCNNGIPENSKVEGPAFTDAIRMYRQSKEQYGTWEMLCGNEVQILSNLVMEELGPALKAELGPRLKGKPQERQRQWIQISDAVYRLVFEQAKVHFEDVLCKLQRARPAMEAVIRTDMDQIITSKEHLASKIRAFILPKAEVCVRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKLSQLAYHPLKMQSCYEKMEPLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFETLLHQELGKGPTKEELCKSIQRILERVLKKYDYDSSSVRKRFFREALLQITIPFLLKKLAPTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYRDSMVLHNSDPNLHLLAEGTPIDWGEQYGDSGDSGGGDSGGSPCPSEAATLTEKRRRAKQVMSVVQDEESGLPFEAGVEPPSPASPDSVTELRGLLAQDLQAESSPPASPLLNGAPVQESSQPVAVPEASPPASPLRHLPPGKAVDLEPPKPSDQETGEQVSSPGSRPPIHTTTEDSAGVQTEF", "function": "May play a role in apoptosis suppression.", "AFDB_id": "AF-Q8R1F1-F1-model_v4" }, { "swissprot_id": "Q90867", "sequence": "MVSKLSHLQVELLGALLESGLTKETLIKGLSEAEPYVLQSESQHAINALQTEKGESCPEIPNLPNGMGETRLSEDETSDDGEEFTPPIMKELENLSPEEAAHQKAVVERLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGILTEEPMGDDLPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEEREALVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDNFSGPQPTSAPPLTPHNSSSLQPPPALSPTKVHGVRYNQQPASEAESSSSNHHGNSSMVTTQTILHQVSPPGLEPSQNLLSTDTKLISAPGGTLPPVSTLTALHSLEQNPHALGQQTQNLIMASLPGVMAIGAGETSSLAPRFTNTGGSTLVIGLTSTQPQSVPVINSMGSSLTTLQPVQFSQQLHPSYQQPLMQQVQSHINQSPFMATMAQIQNPHALYGPKSEVAQYTHTGLLPQTMVITDTANLSALTNLTPTKQAFTSDSETHTDSGIHTPVSQAPAIHLQNQDTAIQHLQSGPRLTPSPAVSSSSLVLYQSSDSTNSHSQLLPSTHNVIETFISTQMASSTQ", "function": "Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator.", "AFDB_id": "AF-Q90867-F1-model_v4" }, { "swissprot_id": "Q5ZMD4", "sequence": "MHQFEEELTCSICYSLFEDPRVLPCSHTFCRSCLEGVIQLSSNFSIWRPLRVPLKCPNCRSIVEIPASGTESLPINFALKAIIEKYRQEDHSDVATCSEHYRQPLNVYCLLDKKLVCGHCLTIGKHNGHPIDDLHSAYLKEKESSGKILEQLTDKHWSDVCLLIEKLKEQKAQCESIVQDDKKVVVQYFKKLSETLEHKKQVLLAALDEINRQILEEYEPHIEKLKKIREEQLELMSLNTSIQKEESPLVFLEKVDNVHQRIKALKEKELPDVKPVEVYPRVGHLLKDVWSKTEIGQINKILTPKIKLVPKRKLHSKNSEKERGKPEELLQAANPLSVTFIFTVIIAIAVLSFHKPISSVVIESIPTHISDFFGFLYQDFCTCMQNTVDVVCHKLNSLAEFLGGIVPF", "function": "May serve as a multifunctional regulator for innate immune signaling pathways.", "AFDB_id": "AF-Q5ZMD4-F1-model_v4" }, { "swissprot_id": "P92983", "sequence": "MATRLLRTNFIRRSYRLPAFSPVGPPTVTASTAVVPEILSFGQQAPEPPLHHPKPTEQSHDGLDLSDQARLFSSIPTSDLLRSTAVLHAAAIGPMVDLGTWVMSSKLMDASVTRGMVLGLVKSTFYDHFCAGEDADAAAERVRSVYEATGLKGMLVYGVEHADDAVSCDDNMQQFIRTIEAAKSLPTSHFSSVVVKITAICPISLLKRVSDLLRWEYKSPNFKLSWKLKSFPVFSESSPLYHTNSEPEPLTAEEERELEAAHGRIQEICRKCQESNVPLLIDAEDTILQPAIDYMAYSSAIMFNADKDRPIVYNTIQAYLRDAGERLHLAVQNAEKENVPMGFKLVRGAYMSSEASLADSLGCKSPVHDTIQDTHSCYNDCMTFLMEKASNGSGFGVVLATHNADSGRLASRKASDLGIDKQNGKIEFAQLYGMSDALSFGLKRAGFNVSKYMPFGPVATAIPYLLRRAYENRGMMATGAHDRQLMRMELKRRLIAGIA", "function": "Converts proline to delta-1-pyrroline-5-carboxylate.", "AFDB_id": "AF-P92983-F1-model_v4" }, { "swissprot_id": "Q92995", "sequence": "MQRRGALFGMPGGSGGRKMAAGDIGELLVPHMPTIRVPRSGDRVYKNECAFSYDSPNSEGGLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVREKVRGASGGALPKRRNSKIFLDLDTDDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTIACDAVLSSKSPYRKQDPDTWENELPVSKYANNLTQLDNGVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSGGNGHALEHYRDMGYPLAVKLGTITPDGADVYSFQEEEPVLDPHLAKHLAHFGIDMLHMHGTENGLQDNDIKLRVSEWEVIQESGTKLKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRREAEANRRPLPELVRAKIPFSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFDVSIDMPDLLDINHLRARGLQPGEEELPDISPPIVIPDDSKDRLMNQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWIIVHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEMENNANANIISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDHKVCASERPPKDLGYMYFYRRIPS", "function": "Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.", "AFDB_id": "AF-Q92995-F1-model_v4" }, { "swissprot_id": "Q0P565", "sequence": "MASASPVATMSGRGARNLLQFLRLVGQLKRVPRTGWVYRNVQKPESVSDHMYRMAVMALVTKDEHLNKDRCVRLALVHDMAECIVGDIAPADNVPREEKHRREEEAMKQLTQLLPEDLQKELYELWEEYETQSSAEAKFVKQLDQCEMILQASEYEDLENKPGRLQDFYDSTAGKFSHPEIVQLVSELEAERNANIAGAASEPCS", "function": "Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).", "AFDB_id": "AF-Q0P565-F1-model_v4" }, { "swissprot_id": "C5CEB5", "sequence": "MIKEFRDLIDSMIPVGKVVKPHGLRGEVKMKSLTNQLKVFETLKKVLLYDEKAGTVVRAEIDTIRRAGKGYIVHFKGFKSVEAAERIRGFYVYAPLNVLPPLKEGEYYFYQLLDCEVYDPEGEYIGKVTDIIETGANDVIVVTKELPDFTVEEELIPVIKDYIVEFRFKDKKIVAKRLEYLTLEGKEDNDDENQRIDDIS", "function": "An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.", "AFDB_id": "AF-C5CEB5-F1-model_v4" }, { "swissprot_id": "Q54G94", "sequence": "MNHRIEDITSNPSSPSPNSPFSSPQVSLQPSIIQNGLNSNNSLLNGNNFNLNGNITSSPSTSSSPPISTTTTTTTTTTTTATAKKTNSKEKKKTTNKDNNNNNNNNNSNNQQQQQQQQQQQQQQQQQQQYEEEDDDEEDEGGDDNTKVGKGEKMKARRTNQNIASRNYRQRKKVYIKEMEDKINSLTLENDSLKKDLYKIGNNPLELLKFSQEVVFLMTQIRRLVFQIDQALRNSEPDSSIKSLLNTWQSTMDQASSINEREIERFVHPYTQAKLTVMGYKPHTNPWTDFIKTPGQEDWWTKYAEKANLSSDQLEQINNLWLRFDEEERVLQKELTDLDEYIKKFFLTKIIIMPDTEKLNDIISSCLPIPENHDGDILQTSEVLEFIYNLEKLKQKFIKVQRLTWDTSKQMSKYLTVRQEAFLLVLVHSNTKYIHTNMDMTNNLWNQLNHSALSKTPSTYLLGGVHSSSSSSSSSSSSMSSSTSRILNNHGIPTPLSSSNSSPSSLSASSSIGESIHSYSQLPNVVQPIQTQPSSMFTPLPGAKPLKNQQPIDDLFFGTIPLSQVPLSFQQNSNMALFSNYRNFTQQQAQQQQQQQQQQHAQQHAQQQAQQQAHLQAQIQAQIMQQAQQIHQVQQAQQASQQAAQQAAQQAAAQQAAQQQAAQQQSPIQTQLSPPQHITPQHTPQQHIQQQQQHQNYQGTEPHLLGEFMFFNSIDATNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSTPIDQLNEYRPDYNNNNTNKILPNIIQSLSASSNNSLFSHQHQQQNSQSPTLPPSQNDSVQFHFYQPIHQNNQNNQNHNN", "function": "Probable transcriptional regulator.", "AFDB_id": "AF-Q54G94-F1-model_v4" }, { "swissprot_id": "Q823E7", "sequence": "MRIFLSAIYWNHSKFLWNSENWPIKVPWYGLCFSLGILFASLLGIYLAKSSYNSEDEKNFSKEQLSGALENFALYSLLFIIPGSRIAYILFYGGDFYFKHPREILKVWNGGLASHGGMLGLILWALIFSWRYRKKISVLTFLFLCDLCASVFGCAAFMIRIGNFMNQEIVGKPTSLPWGIIFSSPAQGVLGVPVHPVQLYEGMSYLLLSIILFFLSYKRYFRLGSGWVTSLGLVGISLIRFFAEFFKSHQGKVIGPNSPLTMGQILSFPLFVFGLCLGIACFLKNKKKRSPTSSVK", "function": "Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.", "AFDB_id": "AF-Q823E7-F1-model_v4" }, { "swissprot_id": "Q5A1Q5", "sequence": "MSRQSFYADPSSAGRQMKYRKDLFPLLDTREITACLLECEFNVTQELIVKPTADFVTNLFEQFLDTFMGIPLGTIRKKARKMSRINPLESDQANGKPQQSPEEDFNDNQENDKTKDTFSALQLLILHRYLAIFFSTCGINDFVLTDIARPDGYRIRRILSAVINFIRFREDQSPKFDHLANECEATADKVSEVQAENSATMQKINAIKEKLEMDSENDESNRKNLQYINSYNRKLETKLRELKVMQERLTKEHDDYKQEKALLAKKLYDINFLYNETQEQVANLTKYAETDLSILVKITEDLSNDLSSMQTNYKNLEKSYQNMGITIDSIQVNEINLKDLLKLAEDITRNVEKRQIEGKILKDNQDNLDELTRKQMELEGQILIVQNQLNKSNKKYQDLIVQADKKESAVKLKLEETKQEFNDILSEKEKHNEEHKRIMDQIVKIQQETTAIQDAFVKESKEVELKLINLMSIIKRYMSDLRNNI", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.", "AFDB_id": "AF-Q5A1Q5-F1-model_v4" }, { "swissprot_id": "Q2Y8V8", "sequence": "MSQSNLQRSMPIVTLPDLFDARFDNRFVRQLPGDPETRNVPRQVRNAGYTQVSPTPVRSPRLLAWADEVGEMLGIARPASPVSPAVEVLAGNRILPSMQPYAARYGGHQFGHWAGQLGDGRAITLGELISPNDKRYELQLKGAGKTPYSRTADGRAVLRSSVREFLCSEAMHSLGVPTTRALSLVATGEAVIRDMFYDGHPGAEPGAIVCRVSPSFLRFGNFEILAAQKEPELLRQLADFVIGEHFPELASSHRPPEVYAKWFEEVCRRTGILVAHWMRVGFVHGVMNTDNMSILGLTIDYGPYGWLEGFDLHWTPNTTDAQGRRYCYGNQPKIAQWNLTRLAGALTPLIEDDAALEHGLAVFGETFNNTWSGMLAAKLGLASLEHSDDDSLLSDLFETLQQVETDMTLFFRCLMNIPLNPISGNRATTFPAPENLESVDQMNDHGLVELFRPAFYDAHQAFSHAHLTRLAGWLRRYIARVRQEGEPEGLRYHRMSRANPKYVLRNYLAQQAIEALERGDDSVIIRLMEMLKHPYDEQPEHEDLAARRPEWARNKPGCSALSCSS", "function": "Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).", "AFDB_id": "AF-Q2Y8V8-F1-model_v4" }, { "swissprot_id": "Q6FSZ7", "sequence": "MVNFYGDSIGEKVEDGDKVRTERLFTESKEIPTVKVSDLPSGYKVLQIPEVTERIGEYRNKFLKYYERTYVKISEYKARKKNELDDRVQYLKKNIFVDKYENEELLAPISLLGLGAFFTGRILTNPTNWGYGALLIKGQPTFFGMFMSSVPARIILPIFLAGYTFNKFLPVTSSKFVETCERDVLPKNVTKAIKDSKRQLYTEGLVNTRKTISQAVYRNCEDAVHRVRMSIAEQLDKW", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.", "AFDB_id": "AF-Q6FSZ7-F1-model_v4" }, { "swissprot_id": "Q02307", "sequence": "MKKNLVKSLAIASAVISIYSIVNIVSPTNVIAKEISNTVSNEMSKKASYDNVDTLIEKGRYNTKYNYLKRMEKYYPNAMAYFDKVTINPQGNDFYINNPKVELDGEPSMNYLEDVYVGKALLTNDTQQEQKLKSQSFTCKNTDTVTATTTHTVGTSIQATAKFTVPFNETGVSLTTSYSFANTNTNTNSKEITHNVPSQDILVPANTTVEVIAYLKKVNVKGNVKLVGQVSGSEWGEIPSYLAFPRDGYKFSLSDTVNKSDLNEDGTININGKGNYSAVMGDELIVKVRNLNTNNVQEYVIPVDKKEKSNDSNIVKYRSLYIKAPGIK", "function": "Responsible for a rapidly fatal enterotoxemia.", "AFDB_id": "AF-Q02307-F1-model_v4" }, { "swissprot_id": "Q9NZH6", "sequence": "MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMNFVHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD", "function": "Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.", "AFDB_id": "AF-Q9NZH6-F1-model_v4" }, { "swissprot_id": "A1A2I0", "sequence": "MKNDQRRLRDRVAVFACIAIAAIAIDQLTKMWALSALADGRTIRVIPGLLSLTLVRNPGASLGMGSGMTWLISLLAMAACVALVVLAVRTISMKWTVLFAFAFAGAFGNLIDRVIYAEGFLNGKVVDFLNYGWSIGNVADIFLMLAGVAAVLLLFLGEPFSQKDLDEANGKTLGDDANATDDGAKAA", "function": "This protein specifically catalyzes the removal of signal peptides from prolipoproteins.", "AFDB_id": "AF-A1A2I0-F1-model_v4" }, { "swissprot_id": "Q8GWW8", "sequence": "MVPSNGAKVLRLLSRRCLSSSLIQDLANQKLRGVCIGSYRRLNTSVGNHANVIGDYASKSGHDRKWINFGGFNTNFGSTRSFHGTGSSFMSAKDYYSVLGVSKNAQEGEIKKAYYGLAKKLHPDMNKDDPEAETKFQEVSKAYEILKDKEKRDLYDQVGHEAFEQNASGGFPNDQGFGGGGGGGFNPFDIFGSFNGDIFNMYRQDIGGQDVKVLLDLSFMEAVQGCSKTVTFQTEMACNTCGGQGVPPGTKREKCKACNGSGMTSLRRGMLSIQTTCQKCGGAGQTFSSICKSCRGARVVRGQKSVKVTIDPGVDNSDTLKVARVGGADPEGDQPGDLYVTLKVREDPVFRREGSDIHVDAVLSVTQAILGGTIQVPTLTGDVVVKVRPGTQPGHKVVLRNKGIRARKSTKFGDQYVHFNVSIPANITQRQRELLEEFSKAEQGEYEQRTATGSSQ", "function": "Chaperone that may play a role in mitochondrial protein folding. Involved in female gametophyte development. Required for cell death of the synergid cells during fertilization process, and fusion of the polar nuclei during megagametogenesis.", "AFDB_id": "AF-Q8GWW8-F1-model_v4" }, { "swissprot_id": "Q5RC98", "sequence": "MTAAAASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVGGTFRMFLLFAVSLCIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHGLFSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTTFYVMVGFFGYVSFTEATAGNVLMHFPSNLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGGILIPNVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLWVGLGILVVSTVTTLSVSEDVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKEREELEQAQIKGPVDVPGREDGKEAQEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDQEVPEENKPPSRHAGRKAPGVQGQMAPPLPDSEREKREPEQGEVGKRPGQAQALEEAGDLPEDPQKVPEADGQPAVQPAKEDLEPGDGGLHPRPQAVLSEQQNGLAVDEGEKAEGVPPPGNAAGDTGQPAEDSDHGGKPPLPEEKPAPGAGLPPEPREQRDVERAGGDQAASQLEEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIHQQRQEDEEDKPRQVEVHPEPGAAVPRGQEAPEGKARETMENLPPLPLDPVLRAPGGRPAPSQDLNQRSLEHPERPVGRDPAGPPDGGPDTEPRAAQAKPRDGQKDAAPGAAGTVKELLKGLEQVPVPDPAREAGGPEERLAEEFPGQSQDVTGGGSQDRKKPGKEVAATGTGILKEANWLVAGPGAEMGDPHMKPKQMSRDLGLAVDLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQGHRLDHGGYLEMRKEARGGDHMPVSHEQLGGEEDAAVPEPRQRPEPELGLKQAVPGGQRPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGELAPRDRVIIGLNPLPDVQVNDLRGALDAQLRQAAGGALQVVHSRQLRQAPGAPEES", "function": "Putative sodium-dependent amino acid/proton antiporter.", "AFDB_id": "AF-Q5RC98-F1-model_v4" }, { "swissprot_id": "Q6FS06", "sequence": "MDSGATSFNVLGEWRRTVQSKLLGERHVGFVAEENKLHCGSIKDRDSVVLTPIANIQQGTVNYNHMFDNLIWVSDVQFMEELQYTLISSPFLNDIHHHQMPLSVANSIMDFHRDRRFHRESFIFSVPTKLGYLKARYGDKKLELRKNINFMDVHKTVYSILKHLRNNNKKCTWRILSVLMIILYLGYEQAHFHNQYPKYSFLTQLKAMMGKLQQFDSIQRKYFENINITKEFDKTGNEIFQLLHSITHIASMKLYHLSEFLLRFTNIGKLSKYCGVYGIDMNLAYLTNVRILTSTKQELHLLQDKIEFLRKFLLCCFLSVEHQDYNEKVKNIIFSTYLLKLFPGYTEDNNCKSLFSSQWSVLSTVIVKFNQDLSFLYSVLNENKELIYSTETREESETDEMLKERYKFRYKDKNQSLMLKALSQIHLVEEQLISVQDADDNEETKCLINDHIKNLQQLILCCNNKTNSGTNFSNRHTSLQGKGLFLDVLKSPEEKFTPIFQEMEVSRIGIKNVSDNDDLESILTDNENYEHIEPAHFIDDRNNGGAFTIYEDSTCYADDCYKNASELRKLNDEQLRRKLNEKIQLFATENKKNRNQIRQQKSLELLRSNSTLTALNELKSNTNYESLDKGVKTKKRAHFMEQELYSEETIPFYYEINDFLYNQANQ", "function": "Required for peroxisome inheritance.", "AFDB_id": "AF-Q6FS06-F1-model_v4" }, { "swissprot_id": "Q5U2Y9", "sequence": "MGERDQSSDTDQERKGGKHPYSSHYSSDFGSSPQSSGPSSPVNTPPCASNREKNPKRHLSDHHVRHQTVRKVSPKAIPNKKGVRVGFRSQSLNREPLRKDPDIVTKRVLSARLLKITELQNEVSELQVKLAQLLKENKALKSLQYRQEKALSKFEDAENEISQLIHRHNGEITALKERLRKSQEKERMAEKRVKDTEGELFRTKFSLQKLKKISEARHLPERDDLAKKLVSAELKLDNTERKIKELSKNLELSTNSFQRQLLAERKRAFEAHDENKILQKELQRLHHKLKEKEKELDIKNIYANRLPKSSPKKEKEIARKHASCQSDFTDLCTKAVQTAEDFEPEEFPFTAQTVLCYENRWDGSEYLPSYLEYQERNEHGSESLSSTLEQEGKYSDDQDSCTAKQETGKSECEWEREELDKVKGKSSLLGRTEKLVLEAGSVQTESYQAQTIDKFQDEAERLKTEMLLAKLNEINKELQDPQSLSRPLLPLLPNFESKLYSPDRSLRPYTFSESLDRSFNGQHLSDMSFLTPRDEGQSPGLIRSPAPSDEFSFGSYVPSFGKTPGKSNPPSQKNSLLDFQSNMSEGLSKDSLDFISRKEKKATLMEQLFGTSASASATNTSASTTTNTTTNTNTNTNTNTNTNCNVPSKSIDSHFPAASRGDLDPLHFLSGDRSSRVREPDGEDEDLFLSEGRSFNPNRHRLKHTSTKPTVTAVDSIDEDIEEVTLR", "function": "Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.", "AFDB_id": "AF-Q5U2Y9-F1-model_v4" }, { "swissprot_id": "Q2NHN9", "sequence": "MLSFEGKVSSGLQKAGQFMEKEVYKKQYLDKLGFIPYHGTLNIKLSNNITLNLDNLHDKLKRIHGNGSFGDVLFLEAYLSTIDEKITKKGAILFPVKTVYDTDTLEYVSSEKLRDTLNLKDGDKVIIKIEK", "function": "Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).", "AFDB_id": "AF-Q2NHN9-F1-model_v4" }, { "swissprot_id": "P26487", "sequence": "MPESLPVHVIDDDDAVRESLAFLLESSGLAVTQHTSAAAFLDAGVPLDRGCIVTDVRMPGISGLELLKELNARGAHMAVIVMTGHGDVPLAVEAMKLGAADFLEKPFDDAAIIAAVRASLGRSAEQGRQEDARSEVGKRIAGLSQRERQVLECLVNGLANKTIAYDLGISPRTVEVYRANVMTKMKAASLPELVRMALLAGVAPADDATPT", "function": "FixJ, when activated by FixL, induces the expression of both nifA, required for activation of classical nif and fix genes, and fixK, required for fixN activation.", "AFDB_id": "AF-P26487-F1-model_v4" }, { "swissprot_id": "Q55484", "sequence": "MLSTEMPLPTTGSTLLKTPASPSPNQNLLPLTAVINKNGELEIGGCSVPALVEQFGSPLYILDETTLRQAAQQYRQSFQAHYPGSSQVIYASKAWSCLAVVAIAAQEGLGFDVVSGGELFTTVSALKQLGWDEAEIAEKIYFHGNNKSVQELQEAIAINCTIIVDNWLELETLTKLAADSGAPVKIMLRLTPGIECHTHEYIKTGHLDSKFGFDPNQLEAVFTYIAQQPSLHCLGLHAHIGSQIFERQPHKDLGEVLVQWFTKGLTYGLPLTELNIGGGLGICYTESDDPPSIEEWAQVAAISVAKACDRQNIPYPKLIAEPGRSLVGSACVTAYRVGGRKVVPNIRTYISVDGGMSDNPRPITYQSVYRVALANRMNDEITETVTVAGKHCESGDILVKDVALPAAEPGDIMVVAATGAYNHSMASNYNRLGRPAAVLVNQGQANLILQRETYTDLLRQDCLPNRLLS", "function": "Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.", "AFDB_id": "AF-Q55484-F1-model_v4" }, { "swissprot_id": "Q8GV50", "sequence": "MIRGGALTHVALGLTVFLLLAVVHSQEKCSKTCIAQKCNVLGIRYGKYCGIGYFGCPGEPPCDDLDDCCMTHDNCVDLKGMTYVDCHKQFQRCVNELKQSIQESNNQKVGFSKECPYSTVIPTVYRGMNYGIFFSGIGNIIIPKKPASAGPVVEVDLARSKADTKDGLGTNQGPQTKDGSKVSVPMNPSPS", "function": "PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli. Plays a role in pollen development and germination and tube growth.", "AFDB_id": "AF-Q8GV50-F1-model_v4" }, { "swissprot_id": "Q9FJZ3", "sequence": "MKLLALFPFLAIVIQLSCWELGTDALPSGGFVRTKGVQFSLNGYPYYANGFNAYWLMYVASDPSQRSKISTAFQDASRHGLTVARTWAFSDGGYRALQYSPGSYNEDMFQGLDFALAEARRHGIKIILSFANNYESFGGRKQYVDWARSRGRPVSSEDDFFTDSLVKDFYKNHIKAVLNRFNTFTKVHYKDDPTIMAWELMNEPRCPSDPSGRAIQAWITEMAAHVKSLDRNHLLEAGLEGFYGQSSPQSKTLNPPGQFGTDFIANNRIPGIDFVTVHSYPDEWFPDSSEQSQMDFLNKWLDAHIQDAQNVLHKPIILAEFGKSMKKPGYTPAQRDIVFNTVYSKIYGSAKRGGAAAGGLFWQLLVNGIDNFQDGYGIILSQSSSTVNVISQQSRKLTLIRKIFARMINVEKWKRARGQGQVGKRGHKINN", "function": "Required for both, loosening of the micropylar endosperm, and rupture of the seed coat in germinating seeds. May participate in the hydrolysis of the mannans in the cell wall of germinating seeds.", "AFDB_id": "AF-Q9FJZ3-F1-model_v4" }, { "swissprot_id": "O67658", "sequence": "MPSLFRASLLFSLGILLSRIFGYVRDATVAYYFGASAVSDAFFIAFRIPNAFRRIFGEGGFNAVFIPFYGEAVKQNREEEFLRKTFGLLITFSLSVVIIGLLFPEEIISVISPGIKEKETFSYAVEFLKFTILYLPLVSFYAYSMAILLVQGKFFVPSVSQTLFNLGFILSLVILFHTLGHYSLALAVLIGGLFQIIPNTFLLFKEKLLKIPKFSLDREIKTFLKKFLFTLGGFSANQLSLFVDTFLASFLKVGSISYVYYAARIYLLPISLFSISLSNTLLALVSTKKDKEKDTDTALKLTLMLSIPSSFGLFFLSREIVSVLYKRGNFSEEDLFYTSGLLSLYAFSVPFYSLQHILKTVYYSKKNVEIPTKSAFLSVFLEALFGSVFIFLLNFGVYSFPLAALISSSSVLVYLYQKLPQKVSIPFGNLIKYLIASSFMGGLVYLTESLTQNPFILVSFIPIYALFYYVFLIILREELAILISYGIFRRGKILQRESN", "function": "Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.", "AFDB_id": "AF-O67658-F1-model_v4" }, { "swissprot_id": "P24514", "sequence": "MMKFMCIFICAVAAVSASGYGGRRPSYGSAPIGAYAYQVQPALTVKAIIPSYGGQRGYGHNQGGYEAAPIASAYGNADIGNQYGPVSGSRYGGAPPVDREAIALAKLALAAPSAGGPLVWREAPRRVQHAYGPSNYGAPQQRYARAEEAQGASAAAASSSVAGVAKKGYRKSSY", "function": "Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment.", "AFDB_id": "AF-P24514-F1-model_v4" }, { "swissprot_id": "B1GZY8", "sequence": "MKKDNNIINFVNFPKQHVPLLKIAAATVLKSEKIKRYQVNFIMVDDKEIRKLNTKYRKIKRITDVISFLVVPEFFMGDIYISKTRSQEQAKEYSNTWQQELAYLVIHGLLHLCGYTDYDAVNKTKMFTKQDKIFKCLFYRL", "function": "Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.", "AFDB_id": "AF-B1GZY8-F1-model_v4" }, { "swissprot_id": "Q82DK2", "sequence": "MADSRDEPLVLGIETSCDETGVGIVRGTTLLADAIASSVDEHARFGGVVPEVASRAHLEAMVPTIQRALKEAGVSAKDLDGIAVTAGPGLAGALLVGVSAAKAYAYALGKPLYGVNHLASHICVDQLEHGPLPEPTMALLVSGGHSSLLLSTDITSDVRPMGATIDDAAGEAFDKIARVLNLGFPGGPVIDRYAREGDPKAIAFPRGLTGPRDPAYDFSFSGLKTAVARWIEAKRAAGEEVPVRDVSASFQEAVVDVLTRKAVRACKDEGVDHLMIGGGVAANSRLRALAQERCEAAGIRLRVPRPKLCTDNGAMVAALGAEMVARGRAASDWDLSADSSLPVTDPHVPGRAHTHAHTHGHDHVHEVSKENLYS", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.", "AFDB_id": "AF-Q82DK2-F1-model_v4" }, { "swissprot_id": "P81476", "sequence": "ETRYEKFLRQHVDHPRTLGLMGHRYCAVMLARRQVTAPGRPCKPSNTFVHAPAEDLVATCTRPADATGFHSTSTPMDITACRLRGGDTRPPCNYRARQLHHHVRVSCLDGLPVHLAGTHAS", "function": "Pyrimidine-specific nuclease with preference for C.", "AFDB_id": "AF-P81476-F1-model_v4" }, { "swissprot_id": "P0DOW4", "sequence": "MASTHQSSTEPSSTGKSEETKKDASQGSGQDSKNVTVTKGTGSSATSAAIVKTGGSQGKDSSTTAGSSSTQGQKFSTTPTDPKTFSSDQKEKSKSPAKEVPSGGDSKSQGDTKSQSDAKSSGQSQGQSKDSGKSSSDSSKSHSVIGAVKDVVAGAKDVAGKAVEDAPSIMHTAVDAVKNAATTVKDVASSAASTVAEKVVDAYHSVVGDKTDDKKEGEHSGDKKDDSKAGSGSGQGGDNKKSEGETSGQAESSSGNEGAAPAKGRGRGRPPAAAKGVAKGAAKGAAASKGAKSGAESSKGGEQSSGDIEMADASSKGGSDQRDSAATVGEGGASGSEGGAKKGRGRGAGKKADAGDTSAEPPRRSSRLTSSGTGAGSAPAAAKGGAKRAASSSSTPSNAKKQATGGAGKAAATKATAAKSAASKAPQNGAGAKKKGGKAGGRKRK", "function": "Unique chromatin-associating protein that contributes to the organism's exceptional tolerance to harsh environmental stresses. Binds with a higher affinity to nucleosomes than to free DNA. Protects chromatin from damage caused by hydroxyl radical-mediated cleavage induced by X-rays or treatment with hydrogen peroxide. Suppresses X-ray-induced DNA damage that includes single-strand breaks (SSBs) as well as more hazardous double-strand breaks (DSBs), and improves radiotolerance. Shields also DNA against reactive oxygen species (ROS).", "AFDB_id": "AF-P0DOW4-F1-model_v4" }, { "swissprot_id": "A0A1D6L709", "sequence": "MPHSVLARLPPGSVRLVAAFGLLLLVSLLVLHRRPGRPHVAAAAASDRLTDPSRSRLFLSQSPGANASIAADLRALTAGPHLAGTPASAGAAAHVLARLRAAGLQTLTREYEPLLSYPGHASLALLRPDGSLLARLSLEEPADEGRRVVPPYHAYAPSGGAVAEAVFVNLGREEDYVVLERLGVGVRGRVAVARRGGGYRGGVVARAADKGAVAVLIAGNADGGVERGVVLLGGPGDPLTPGWAATSGAERLKFDDKAVKQRFPSIPSMPVSAKTAAAIIRSLGGPAIPAEWKDGLGVDTGGLGPGPTLVNFTYQEDRKFYKIRDIFGIIKGQEEPDRYVILGNHRDAWTYGAVDPNSGTAALLDIARRLGIMLQSGWKPRRSIILCSWDGEEFGMIGSTEWVEDNLEDLHSKAVAYLNVDCAVQGVGFFAGSTPQLDKLLVDITRQVRDPDVTGKMVHDTWNEMSGGIKIERLARTDSDFAPFLHHAGIPSVDLYYGEEFPGYHTALDTYNWMEKHGDPFFLRHLAITEIWGLLALRLANDPVLPFDYQAYTSQLQEHIKTLSALTSNGHAVNLMNGCVNDLSGAAMEVLKEMKKLQQMDLYDEHARMRRRLLNDRLLLAERSFLQPEGLQGRGWFKHLLYSPPEDYESKLSFFPGIADAISRSANLSDKEQEVAMQHEVWKVCRAIQRAASVLRGEFSEQKPTNFSSLVTP", "function": "Involved in the regulation of meristem development and seed maturation processes. Mediates regulation of embryonic regulatory genes and genes controlling abscisic acid (ABA) biosynthesis and turnover in developing seeds. May be required for the synthesis of small signaling molecules that integrates meristem and embryo formation in seeds.", "AFDB_id": "AF-A0A1D6L709-F1-model_v4" }, { "swissprot_id": "P98066", "sequence": "MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARSGKYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGFQIKYVAMDPVSKSSQGKNTSTTSTGNKNFLAGRFSHL", "function": "Major regulator of extracellular matrix organization during tissue remodeling. Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin. Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization. Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling. Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation. In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium. Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts. Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation.", "AFDB_id": "AF-P98066-F1-model_v4" }, { "swissprot_id": "O66663", "sequence": "MQFEVLKRFFPKESLKNCKGALWVHTASIGEFNTFLPILKELKREHRILLTYFSPRAREYLKTKSDFYDCLHPLPLDNPFSVKRFEELSKPKALIVVEREFWPSLIIFTKVPKILVNAYAKGSLIEKILSKKFDLIIMRTQEDVEKFKTFGAKRVFSCGNLKFICQKGKGIKLKGEFIVAGSIHTGEVEIILKAFKEIKKTYSSLKLILVPRHIENAKIFEKKARDFGFKTSFFENLEGDVILVDRFGILKELYPVGKIAIVGGTFVNIGGHNLLEPTCWGIPVIYGPYTHKVNDLKEFLEKEGAGFEVKNETELVTKLTELLSVKKEIKVEEKSREIKGCYLEKLREFLRGL", "function": "Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.", "AFDB_id": "AF-O66663-F1-model_v4" }, { "swissprot_id": "Q32KS0", "sequence": "MNSTSTSDVIGRRVEVNGEHATVRFSGLVPPVAGLWLGVEWDNPERGKHDGSHEGTVYFKCRHPTAGSFIRPHKVNFGVDFLTAIKNRYVLEDEPKEEETEQIVIIGNKPVETIGFDSVIKQQSQLSKLQDVSLRNCAVNGAGDKGEIAKACPNIRSIDLSKNLLSSWEEVIDIADQLKHLEVLNLSENKLTSPSSSPSPTGTFPTLKVLVLNRTGVTWAEVLRCASGWPVLEKLYLESNNIIISERPTDVLQTVKLLDLSSNQLIDENQLFLIAYLPRLEQLILSDIGISSIHFPDAGIGCKTSMFPSLQYLVLNDNQIAQWSFMNELDKLQSLHALSCTRNPLTEGSKDAQTTRQFIIARIGQLRTLNKCAIEPEERRGAELDYRKAFGNEWKKAGGHQDPEKNRPNEEFLAAHPRYQALCLKYGAPEDGELKTQQPFLLKNQLLTLKIKYPNQHDQKVIEKQLPDSMTVQKVKGLLSRLLKVPVSELLLSYESPKMPGKEVELENDLQPLRFYSVENGDCLLVRW", "function": "Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.", "AFDB_id": "AF-Q32KS0-F1-model_v4" }, { "swissprot_id": "Q8LF65", "sequence": "MLTTTILILLIVILMVSLHLYYRWYLLRSSPFNRTTAASTFFTDPSSTPGGLNPSIIKSLPIFTFSAVTALFAMECSVCLSEFKDNESGRVMPNCKHTFHVHCIDMWFHSHSSCPLCRSQIEPFAGGVKSSMDEVAISISDPVYGDTNHHEGTETTGDSVPEDSQRKPAAIEISQRNLGEIENDLSRSHSFRSPTDEPDDIFHSEFESRSGEVLLLLLLLSEFLIFCFRRSVACK", "function": "May be involved in the early steps of the plant defense signaling pathway.", "AFDB_id": "AF-Q8LF65-F1-model_v4" }, { "swissprot_id": "P59277", "sequence": "MSRFRDRTEDFKDSVRNSAVSIGYNESKVASTMASFIIHKPKERSPFTKAAFKTLDSIKELELFMLKHRKDYVDLHRTTEQEKDSIEQEVAAFIKACKEQIDILINSIRNEEANSKGWLGLPADNFNADSIAHKHGVVLILSEKLHSVTAQFDQLRATRFQDIINRAMPRRKPKRVIKEATPINTTLGNSESIEPDEIQAQPRRLQQQQLLDDETQALQVELSNLLDGARQTETKMVEMSALNHLMATHVLQQAQQIEFLYDQAVEATKNVELGNKELSQAIQRNSSSRTFLLLFFFVLTFSVLFLDWYS", "function": "Vesicle trafficking protein that functions in the secretory pathway.", "AFDB_id": "AF-P59277-F1-model_v4" }, { "swissprot_id": "Q9P3T9", "sequence": "MSTNSNQNSIHTPIPEFPENRSTNRSELAAAFEPPDDDVEYSETAPLYSSARASIEGEEAFYQHLSTPDPGNDSGHVRSSNDRIPSTSSNHADGHHVDSVFSNLSAKPTVESNTEELEEEPPSYEQAAADTAPPYWDTTMVIPDYGSNEIYIDGMSVGTGFSFVWSACVAILFPFVGFLVTYVLSTTHLGRYGAQIGLSLTLFQRGYIMISESGMENNDDQYNYDELPHQKLIGSILIIIGWCLVLVDTFGFIRIRRMKNAISRTDSPGETSPEEVV", "function": "Required for homeostasis of heavy metal ions such as cadmium, cobalt and copper.", "AFDB_id": "AF-Q9P3T9-F1-model_v4" }, { "swissprot_id": "P41894", "sequence": "MKSNTYELHNYADLNDMARATDSKDSRKRKTASARGEKYSLRQKRQKRGSNEDGESANLADFQLELDPIAEPASKSRKNAPTKSKTKAPPLSKYRRKTANARERTRMREINTAFETLRHCVPEAIKGEDAANTNEKLTKITTLRLAMKYITMLTDSIRDPSYESEFIGECLEESANREARVDLEANEEAEVELPVPVAKKPAKTKGSGKKSSAASKRQSQKQAKIVPQIPPISSGESCYATSSIGSPASSAYASLSSSSNSHSSSSSPGLELDSLVGLNGISALDSLLLDTSDGDSLSCLSPGYGSLLTGSGESLLPGCRGDLPMSGLEKSDVELSLRLLDQSSKDSFDFASDQQPSACISSFSALDGYPFDLLHSDFPDMFLT", "function": "Probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles.", "AFDB_id": "AF-P41894-F1-model_v4" }, { "swissprot_id": "Q6B8L1", "sequence": "MTYTYLHNKFLSIIPKYKNLIKPLSILIALSGGKDSLCLVKLIEDFNNTYNHFSRIEYIYIDHQWRSDSKQNIKHLLNYISITNNNTYIYQINKMEISEANMRNIRYQAIVRHAIQNSHDIIVTGHNQTDQVETFLLNLMRGTGLEGLSSLPYIRKITDQIQVIRPLIHINTGDVLWFCRKFNLPIWSDKTNFYYTNFRNRIRYELLPYLKEYFHPKIESNIINFLSLSSIENEYIKQNSIKLYLASRHSHYIAINYKIIKNQHLALQKRVLNIFFYHNFNKYVNSHILNQLIKMKYQRKLTIVWETLRIKIYKNWIYIQ", "function": "Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.", "AFDB_id": "AF-Q6B8L1-F1-model_v4" }, { "swissprot_id": "Q9KAH2", "sequence": "MKLCYNQATTLENSNLVKDLEYCEKNGYDYIEIRTMDKLPEYLKDHTLDELKHFFQTNHIKPLALNALVFFNNRDEAGYKEIITEFKGMMETAKALNIPYVVAVPLVTEEKILKSEIKRSCVNVLTELSEIAKPYGVKVALEFIGHPQCTVNTFGQAYEIVEAVGRDNIGLVLDCFHFHAMGSNISDLEKADISKIFILHMDDTEDFPVGFLTDEDRVWPGHGAINLDQMLSILKEKGYSGAVSVELFRPEYYQLSAEEAIKTAKDTTVEVVSKHFTLETTK", "function": "Involved in the reversible interconverion of 2-keto-myo-inositol (2KMI, inosose or 2,4,6/3,5-pentahydroxycyclohexanone) to 1-keto-D-chiro-inositol (1KDCI or 2,3,5/4,6-pentahydroxycyclohexanone).", "AFDB_id": "AF-Q9KAH2-F1-model_v4" }, { "swissprot_id": "Q38BU9", "sequence": "MRLWNRFSRLGNLLCACAACGCSFTPWRCSSSPLLSSFSAYNMSSGNRVTSSVGGSSGATEVCPSHTPLSSSTLLRYTIAPSEPTMGSPWQTSEESASRRLAALTSYPPSNIRNVAVVAHVDHGKTTLSDVLLRRTGVLKGSVNAGAYTDRLLVERERGITVKSQTCSMFLKYGGSEFLLNLIDTPGHVDFQYEVSRSVRAAQAVLLLVDVAQGIEAQTMSHFHMALDQGLAIIPVFTKMDCVLNDTTVDAALQQLEDSTGLLRSEVVFTSAKEQLGVEALLQAIIERVPSPSGAIGLSDVCQLPPLLPGSTARVAMEAEMVPLRAILLDSWTRECGGGLYRPPSKTSSALSGNVKIDEDKDTVTCLVSVIDGTLTARTNILLYHSQKRYEAREVGVIHPELRPTGALTVGMVGYVVFTRVQREDFSVGETLYTLPTRKFTRGGIAPVPGFRRVHPVVFAGFYPDEGEYVTQLREAVEKLRMNDPAVTVEPLECQALGSGLQLGFLGVLHMQIFQERLLSEFGQRVLVTPPVVQYKYREAAGGDDQPPKPLSVHTWRWLHEGVSCYMEPHVTATVVTPSEYAQIIDGEAQRHYRGKQLDMRVMDDARVLLRYKMPLADMVRGFFTFVKSQSHGYASLEYDELVYEEADLVRVDIVVQKARISALAVICPRHEAPSVGKRIVASLKSNLTRTAVDIPLQALVGSKVVARETVRAYRKDVTAKIHAGDISRKQKKWNDQKKGKERMARRTVGGVTLDQSVLAAAMGATAL", "function": "Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.", "AFDB_id": "AF-Q38BU9-F1-model_v4" }, { "swissprot_id": "Q969V6", "sequence": "MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL", "function": "Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.", "AFDB_id": "AF-Q969V6-F1-model_v4" }, { "swissprot_id": "P18494", "sequence": "MQDDPENSKLYDLLNSHLDVHGRSNEEPRQTGDSRSQSSGNTGENEEDIAFASGLNGGTFDSMLEALPDDLYFTDFVSPFTAAATTSVTTKTVKDTTPATNHMDDDIAMFDSLATTQPIDIAASNQQNGEIAQLWDFNVDQFNMTPSNSSGSATISAPNSFTSDIPQYNHGSLGNSVSKSSLFPYNSSTSNSNINQPSINNNSNTNAQSHHSFNIYKLQNNNSSSSAMNITNNNNSNNSNIQHPFLKKSDSIGLSSSNTTNSVRKNSLIKPMSSTSLANFKRAASVSSSISNMEPSGQNKKPLIQCFNCKTFKTPLWRRSPEGNTLCNACGLFQKLHGTMRPLSLKSDVIKKRISKKRAKQTDPNIAQNTPSAPATASTSVTTTNAKPIRSRKKSLQQNSLSRVIPEEIIRDNIGNTNNILNVNRGGYNFNSVPSPVLMNSQSYNSSNANFNGASNANLNSNNLMRHNSNTVTPNFRRSSRRSSTSSNTSSSSKSSSRSVVPILPKPSPNSANSQQFNMNMNLMNTTNNVSAGNSVASSPRIISSANFNSNSPLQQNLLSNSFQRQGMNIPRRKMSRNASYSSSFMAASLQQLHEQQQVDVNSNTNTNSNRQNWNSSNSVSTNSRSSNFVSQKPNFDIFNTPVDSPSVSRPSSRKSHTSLLSQQLQNSESNSFISNHKFNNRLSSDSTSPIKYEADVSAGGKISEDNSTKGSSKESSAIADELDWLKFGI", "function": "Positive nitrogen regulatory protein. Required for the activation of transcription of a number of genes (including the allantoin pathway genes) in response to the replacement of glutamine by glutamate as source of nitrogen. Binds the nitrogen upstream activation sequence of GLN1, the gene encoding glutamine synthetase. URE2 may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.", "AFDB_id": "AF-P18494-F1-model_v4" }, { "swissprot_id": "J9R393", "sequence": "MRSFSSFHISPMKCKPALRVHPLCDKLQMEMDRWCVDFASPESSDEEMRSFIAQKLPFLSCMLFPTALNSRIPWLIKFVCWFTLFDSLVDDVKSLGANARDASAFVGKYLETIHGAKGAMAPVGGSLLSCFASLWQHFREDMPPRQYSRLVRHVLGLFQQSASQSRLRQEGAVLTASEFVAGKRMFSSGATLVLLMEYGLGVELDEEVLEQPAIRDIATTAIDHLICVNDILSFRVEYLSGDFSNLLSSICMSQGVGLQEAADQTLELMEDCNRRFVELHDLITRSSYFSTAVEGYIDGLGYMMSGNLEWSWLTARYHGVDWVAPNLKMRQGVMYLEEPPRFEPTMPLEAYISSSDSC", "function": "No terpene synthase activity detected in vitro.", "AFDB_id": "AF-J9R393-F1-model_v4" }, { "swissprot_id": "P13485", "sequence": "MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLGSLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPVEMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGNFSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEEKFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDDEGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLKTRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGKQYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEYWVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASNWDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDKKVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPFEGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGFYFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVNTVFKAE", "function": "Responsible for the polymerization of the main chain of the major teichoic acid by sequential transfer of glycerol phosphate units from CDP-glycerol to the disaccharide linkage unit. Synthesizes polymers of approximately 35 glycerol phosphate units in length.", "AFDB_id": "AF-P13485-F1-model_v4" }, { "swissprot_id": "P39914", "sequence": "MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAFANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAAIEQHLS", "function": "S-bacillithiolation is the formation of mixed disulfide bonds between protein thiols and the general thiol reductant bacillithiol (BSH) under oxidative stress. BSH is an equivalent of glutathione (GSH) in Firmicutes. This protein is a monothiol bacilliredoxin, which debacillithiolates (removes BSH) the S-bacillithiolated glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) GapA and GapB in vivo and probably a number of other oxidized cytosolic proteins. Debacillithiolates the S-bacillithiolated Bdr (Bdr-SSB) and BrxB (BrxB-SSB) in vitro. Involved in maintaining redox homeostasis in response to disulfide stress conditions.", "AFDB_id": "AF-P39914-F1-model_v4" }, { "swissprot_id": "Q9CIR9", "sequence": "MKKKREKLVLKSEIIAQMPKVELHCHLDGSLSLSVIKELAKNAGIHMTMSDEEILEKAQAPENTKNLLEYLQRFDFVLPLLQTYKNLELAAYDVVRQAANDNIKYIEIRFAPSQHLLENLTLEEAVEAVIAGLSRAENDFDIRANALVCGLKQEPIQKLQKLLPLFDKIPDEHLVGFDMAGDELNYPQEKFVDLIHDIKIKGVNVTLHAGECPACEKNILDSIAMGASRIGHGIMTKNLSEAEQKMMIEKQIVLEMAPTSNFQTKAVTELAQYPFKELYDKGIHVTLNTDNRMVSATNLSKEYEKISAWYPDFSLSDFEKINHYAIDGAFIGQEEKEELHQRFTKEYKKISE", "function": "Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.", "AFDB_id": "AF-Q9CIR9-F1-model_v4" }, { "swissprot_id": "P68514", "sequence": "MITFFEKLSTFCHNLTPTECKVSVISFFLLAFLLMAHIWLSWFSNNQHCLRTMRHLEKLKIPYEFQYGWLGVKITIKSNVPNDEVTKKVSPIIKGEIEGKEEKKEGKGEIEGKEEKKEGKGEIEGKEEKKEVENGPRK", "function": "Involved in cytoplasmic male sterility (CMS) by leading to pollen abortion. Not expressed in fertile (normal) plants.", "AFDB_id": "AF-P68514-F1-model_v4" }, { "swissprot_id": "Q9ASS7", "sequence": "MGFLVDTQKEGGGHSWGYVRSLVRRKQVDSANGQSHGHQLARALTVPHLVAIGVGATIGAGVYILVGTVAREHSGPSLALSFLIAGIAAGLSAFCYAELSSRCPSAGSAYHYSYICVGEGVAWIIGWALILEYTIGGSAVARGISPNLALIFGGEDGLPAILARHQIPGLDIVVDPCAAILVFVVTGLLCMGIKESTFAQGIVTAVNVCVLLFVIVAGSYLGFKTGWPGYELPTGFFPFGVDGMFAGSATVFFAFIGFDSVASTAEEVRNPQRDLPIGIGLALLLCCSLYMMVSIVIVGLIPYYAMDPDTPISSAFASHDMQWAVYLITLGAVMALCSALMGALLPQPRILMAMARDGLLPSIFSDINKRTQVPVKATVATGLCAATLAFFMDVSQLAGMVSVGTLLAFTMVAISVLILRYVPPDEQPLPSSLQERIDSVSFICGETTSSGHVGTSDSSHQPLIVNNDALVDVPLIKNQEALGCLVLSEETRRIVAGWSIMFTCVGAFLLSYAASSLSFPGLIRYPLCGVGGCLLLAGLIALSSIDQDDARHTFGHSGGYMCPFVPLLPIICILINMYLLVNLGSATWARVSVWLLIGVIVYVFYGRKNSSLANAVYVTTAHAEEIYREHEGSLA", "function": "Permease involved in the transport of the cationic amino acids.", "AFDB_id": "AF-Q9ASS7-F1-model_v4" }, { "swissprot_id": "Q9ES83", "sequence": "MNSTESIPLAQSTVAGFTSELESLTPVPSNETTCENWREIHHLVFHVANVCFAVGLLIPTTLHLHMILLRVMLSLGCTLYVVWATLYRCALDVMIWNSVFLGINILHLSYLLYKKRPVKIEKELGGVYHRLFEPLRVPPDLFRRLTGQFCMIQTLKRGQVYATEDKTSVDDRLSILLKGRMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIVADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKVKKLEPQMSLCTQISMLEMRNSITSSSDGEDGLHHFLRGSSSTASLPMSSPQQRASAKMKPIEEGVEDDDEVFVSPDALKVHQLP", "function": "Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.", "AFDB_id": "AF-Q9ES83-F1-model_v4" }, { "swissprot_id": "Q2LKX9", "sequence": "MSAHKVQIGLSSGQFRVALQVPSVRLKGLGSFHTGSIVLPSQGSLREDQISLHNQDGLHKVMREVLGYERNSYKKFFLR", "function": "Has antifungal activity against C.albicans. Has antibacterial activity against the Gram-positive bacterium S.aureus and the Gram-negative bacterium E.coli. Lacks hemolytic activity against rabbit erythrocytes.", "AFDB_id": "AF-Q2LKX9-F1-model_v4" }, { "swissprot_id": "Q0A5D6", "sequence": "MFDLGFWEVLIIMLIGLLILGPERMARAVRMAGLYMGKARAAFNAAKSEVERELQVEEMRKATESVRKDVDKVRKDVEKNARRFEAEADGVGKTFRDVGRQADDAAKGAASGAGGDDARSAGAGDPSGLTDQRGSDQPPAGGGRTAAGERGEPAEAAPAQQSEDTARKGQGGGGEEKRQ", "function": "Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.", "AFDB_id": "AF-Q0A5D6-F1-model_v4" }, { "swissprot_id": "Q557C9", "sequence": "METIVNNQNNGQQNTVPTQSFSSSVYMNYDFFDSQQLQQPQHQPQHYQQQDSFVSPNLDNNNPQIHVQSNNYNQNGFVGYNNSNNNNNNNQHMNNQYSNSFHNNNSSGFMAFQNNSSNFNNQNNNNSNNNNNNNNINSYDYNNSNNNNYNNNNNTHSNNSNNNNNNNNSNYWNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNHHHHHHQQQSQPTSPYNNPIQHNPNDMKFNGQHNPFNGNQMVMDNNNNNNNNNNSNVFNSNSNSNVFNSNSGSFLQINNNNGSFSSYNNNNNNNNNNNSNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNQFSQSYDSTLGNNRFSSMMGQPIQQQQSPPQQQQQQSFIQSSPQAIPASNCNGNGSTSSSTSPLSPTLIGSAPGTPTSMLATTLFGFNLSSSPTSSPSSPVKKGKSQSALALSSSGGSGGSSGRKKPQKHDSMSSITNTNLKSTQASTLKESKRSNSSPNLKKQMQLQQLQQQQKLNENGTLIPPLPFASISENITNNNNNNNNNNNNNNNNNNNNNITNNPLSGSMEFPNSNNINQSSDSINGEFNIGQPESPKMYNSSPSPPPNATSTTKGGKKSKKSLHISTTQQSPSLNGSTGGSMLTPTMSGLSLSGGGSGGGFSPLISPTGTTSNKDLQSSPSPSPLLKSMSMGKLDLQDSIDSMSSPLSPNSSLSSSNGLLPPPPNSNNMNSSGGIPTPSTPTSPPPLTHHINIFSNLEFVKQLKDHLLPNDFKPEEHALERNLLRFQQFVKTLAEPLQRDVVTSMFELSVDAQLQYGSNLDNDNLSALMLFRRKILNFNLFRMMMLNDPNSFIPLPSPFPIQTTTISSNGTIVNPTNVNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTTTTTTTSANTVQSGTTSNSNLVFQQTSNSNTLSPSQQQQQQTQQQQSINGSSTGSLSDAQYQDLGIHLDTSSANSGCGINVSIGSSIGGGGGGSSLNGSNLNGSSSISGSISGGSSNGGGQFIMSPQFSLDGAYQQQQPSSYNINNEMELAEKDEDEIFNNNNKDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSSINSNINNVNNCNINNNSNSNNGSINSPRPSTPTTLNSSGKRSKKIYRGDSFGAGNDISTGLMASSDQIIPPPQQQQHQQLVNNNNNNMNNSENNILLADSNKGLSVSLGSLPTNTPSSMEIEQQQQQQQQQQQQQQQQHLNQQQILHQQLHHHLSSSLGGAQFTNIQQQQQQQSGNIFYNSPYNSSQVYMNPYGTSITNTSLAGPSTTSSAMQHMITNMTSSNIIVNNQNNNNNDQNNNNNNNNNNNSTTNSNVNNNNNTTNTPSSPPQPNNCTPTQTSIITSNGVVVPSLQMRGTITNPPPVLPTPDTLVLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQETPHTPTSNSISSPRSSPVHQQSPSNTNTTTTSTTTIRHSAVTQLSFAGLHNQQVSPISPRSPRSPHGTSGDYNDGSQSPSSRRKNRFTDFQIKRMNDCFENLDKNNNGKFTSEEICQIATELGLTDQQVRVFFQNKRARSRPSPRGQPTNPLTSSTNNGNNSNLALQHLQQQHLQQVQQQQQQLLQLQQQQQQQQQQLHQQSANTTPQLNSMNPNSINYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNITTINE", "function": "Putative transcription factor.", "AFDB_id": "AF-Q557C9-F1-model_v4" }, { "swissprot_id": "O75899", "sequence": "MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL", "function": "Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).", "AFDB_id": "AF-O75899-F1-model_v4" }, { "swissprot_id": "Q52620", "sequence": "MAENVVNDILKWLETQLQRNEGIKIDTIANKSGYSKWHLQRIFKDFKGCTLGEYVRKRRLLEAAKSLQEKDMSILDIALMYGFSSQATFTRIFKKHFNTTPAKFRENGTMPDTHCFMSCETH", "function": "Regulatory factor of blood coagulation.", "AFDB_id": "AF-Q52620-F1-model_v4" }, { "swissprot_id": "Q13351", "sequence": "MATAETALPSISTLTALGPFPDTQDDFLKWWRSEEAQDMGPGPPDPTEPPLHVKSEDQPGEEEDDERGADATWDLDLLLTNFSGPEPGGAPQTCALAPSEASGAQYPPPPETLGAYAGGPGLVAGLLGSEDHSGWVRPALRARAPDAFVGPALAPAPAPEPKALALQPVYPGPGAGSSGGYFPRTGLSVPAASGAPYGLLSGYPAMYPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLGPGTVGTGLGGTAEDPGVIAETAPSKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEGCGWRFARSDELTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKRHL", "function": "Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.", "AFDB_id": "AF-Q13351-F1-model_v4" }, { "swissprot_id": "Q54LT0", "sequence": "MNSFVIRNGFGLVRTFNTRLFTTSTQNLEGELKTILGQAKVSKLQEKLKLDPRSKITFNDFKGIAKEVGIEEKEINSVSNALAQSGSIIYLPNSLNENLKTSVFTKPAHIYQSLEHILDIENKGVGLNKLIESKKSEINSLRQKIQPLEEKKQVIDRKAHRRATAIIWTGLGYCFAQAAILARLTWWDLSWDIIEPVSYFLTFGSVLIGYTYFTMTKTEFTYEALNHRLFSKRQDKLFKRNNFPKEDYENLVQAIDKKEKELKELELATKYDHTH", "function": "Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.", "AFDB_id": "AF-Q54LT0-F1-model_v4" }, { "swissprot_id": "Q08032", "sequence": "MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDENDNNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVKRLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYRNPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL", "function": "Required for initiation of chromosomal DNA replication. Acts at the origin of replication. Also has a role in minichromosome maintenance.", "AFDB_id": "AF-Q08032-F1-model_v4" }, { "swissprot_id": "P0A0C2", "sequence": "MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHELHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD", "function": "Involved in resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region. The C-terminal region is a kinase that phosphorylates several 4,6-disubstituted aminoglycosides.", "AFDB_id": "AF-P0A0C2-F1-model_v4" }, { "swissprot_id": "A6TRK6", "sequence": "MSALAYPRVNRLAEEIKKIISHMIRNDLRDPRIAKMTSIIEVNVTRDLRFATIYISVLGDQQEKEETIEGLKKSSGFIRKEVGRQITARFTPELIFKLDESIERGVYMYDVISKVTQKDMDEKKNSDEKRDSDEKLED", "function": "One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.", "AFDB_id": "AF-A6TRK6-F1-model_v4" }, { "swissprot_id": "Q0JL44", "sequence": "MATAAASDLESKAKAAFVDDDFELAAELYTQAIEASPATAELYADRAQAHIKLGNYTEAVADANKAIELDPSMHKAYLRKGAACIRLEEYQTAKAALELGYSFASGDSRFTRLMKECDERIAEELSEVPVKKAEDGAAAPSVASFVEEKDDAANMDNTPPMVEVKPKYRHDFYNSATEVVLTIFAKGVPAENVVVDFGEQMLSVSIEVPGEEPYHFQPRLFSKIIPEKSRYQVLSTKVEIRLAKAEQITWTSLDYDKKPKAVPQKIIPPAESAQRPSYPSSKSKKDWDKLEAEVKKEEKEEKLEGDAALNKFFRDIYSDADEDMRRAMMKSFVESNGTVLSTNWKDVGSKKVEGSPPDGMELKKWEY", "function": "Involved in basal disease resistance to bacterial blight (X.oryzae). May act as positive regulator of basal defense. Probably required for SCF-mediated ubiquitination, by coupling HSP90 to SCF complex for ubiquitination of HSP90 client proteins.", "AFDB_id": "AF-Q0JL44-F1-model_v4" }, { "swissprot_id": "Q78IQ7", "sequence": "MLPKSVTQGLVLALLVGTVAVARPRNLLSLLALGQGALDRLELDGLLNTLVARVHCTDGPCEKCLSVENVLALGKPDKPQPAPESVLESRHIIYLSAAAALYLNNPEKTCKDIQAGLLASHVDDYLATLESPEAMTLGLSQLLQKIEAHAASQPTGEKTCVDLPQLLEEAEAAGVSKSAGLVLTALLDHVINGSCFQGLPSPQYFVDFVFRLHSSDPPNITLHELENLMHHLGVGGEDHSDHDDHGDHADHSHPDRKASHQDSELHTPHNSNSSVWDTLCLSAKDIMAVYGLSEEAGVSPQAWAQLTPALVQQQLSGACSPYPTIRIQDQLSQTERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHGGEGHTHEEEVGVGGQATWRLLAVLGGFYIFFLFESFFNLLLPRDQDSEKDGPCSHGGHSHGISLQLAPSNLRQSKQTHESSRSDLVAEETPELLNPETRRLRAELRLLPYLITLGDAVHNFADGLAVGAAFSSSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVKRALLLNLASALTAFAGLYVALAVGVGEEGEAWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTVLLLLSLYEDNITF", "function": "Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.", "AFDB_id": "AF-Q78IQ7-F1-model_v4" }, { "swissprot_id": "P04390", "sequence": "MSLRSDLINALYDENQKYDVCGIISAEGKIYPLGSDTKVLSTIFELFSRPIINKIAEKHGYIVEEPKQQNHYPDFTLYKPSEPNKKIAIDIKTTYTNKENEKIKFTLGGYTSFIRNNTKNIVYPFDQYIAHWIIGYVYTRVATRKSSLKTYNINELNEIPKPYKGVKVFLQDKWVIAGDLAGSGNTTNIGSIHAHYKDFVEGKGIFDSEDEFLDYWRNYERTSQLRNDKYNNISEYRNWIYRGRK", "function": "A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GATATC-3' and cleaves after T-3.", "AFDB_id": "AF-P04390-F1-model_v4" }, { "swissprot_id": "Q8F3Q1", "sequence": "MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI", "function": "Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. Shows strict substrate specificity for pyruvate. Cannot use alpha-ketoisovalerate, alpha-ketobutyrate, alpha-ketoisocaproate, alpha-ketoglutarate or glyoxylate.", "AFDB_id": "AF-Q8F3Q1-F1-model_v4" }, { "swissprot_id": "Q97QZ1", "sequence": "MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQEYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEELYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEMLQVGEKRLNELLEK", "function": "Acts as a corepressor of its own operon with PezA; it is not clear if it binds DNA alone.", "AFDB_id": "AF-Q97QZ1-F1-model_v4" }, { "swissprot_id": "P40462", "sequence": "MSDNLLSLENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAHATIGSTKFDLKISQDTGKHLSIFNSESPIQLSNDCPLILSVQYVGKIRDIKTHHDKTFGIFKTNFMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPVEMVEALDSSQKHLVKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIYAPWDIANAAFTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIPPNALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWTSEPYLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLESVFEDTKTFHARSVKPMDIWNHIGKFLKSQNITNFVSSWTRTPGLPVVKVEVEEKDGKTQTKLTQHRFINQLSTEEKDQLEDVPYQVPLFGVLPDGKMDTKNVLLTDRTLKFDYPILVINHLAQGYYRVSYESEECYALINDKITEETLSEIDLRKIFLDLSQFIGDEGFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGLEVLQTIDRASLTSSKLQSFLKKKIVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQGPRSSVPLELVNSILVVVSQHCANIKQWKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCLDSDIVKKTLNFITSNIESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKATRKGTTTGDHLHKALRSISLIIFQMFVADEPQKIEKFINLEKEKLGQSLLSLDDIWASVQQDEESRKTIRRDLASLV", "function": "Putative zinc aminopeptidase which may be involved in ribosome biogenesis.", "AFDB_id": "AF-P40462-F1-model_v4" }, { "swissprot_id": "Q569E4", "sequence": "MVPAACMLLWALLLSLEYRAAGAEDQTTTPTATTIGMQRVSFRFGGPARSLHSTNPTARTTVPGKLRVTLEDENDALATADRLALPAAAELLSTVTGYSRSSVPSPSDWEEDGSLEEGVVDTRKTTNGPVSLFSTTNTVGSSGTTGRFLANSQEREIKLTTDVRSLSSKTTVVDLSSESTLQQWSTPGSTPSPWLKPSFTAMPSPEDLRVVLMPWGPWHCHCKSGTMSRSRAGKLHGLSGRLRVGALNELRTEHRPCTYQLCACNRHLEECPLDSSLCSDHSCSSRAPFQSSTTSLVPVHLRRRPILPPTSPSPSPALAFWKRVRIGLEDIWNSLSSVFTETQPVERIQR", "function": "Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.", "AFDB_id": "AF-Q569E4-F1-model_v4" }, { "swissprot_id": "Q54U71", "sequence": "MIKSILSLQNFKFIKPCTNSSILKYNNNNNTNNNNNNNGINKYNSTFNNNNSNFSNKNLFSSKQYQQQSICNIPILSTISYHNKNNTNINTIINNNNSSNNNLINLNDKFNNLNNKTSPIIFNKNYSTTVSTLLDDNNSNSNNNNNSNNNKPSTTFVNDWISKFPNSVQPYLRLSRVDKPIGVWLLLYPCCWSISLAAPAGSFPDLKTMLVFGIGAYVMRSAGCVINDMADYKFDSKVERTKTRPIASKQLTHKQSLIFLGGQLLASFGLILSSLNYYTIALCASSLPIVVLYPFMKRFTYYPQFVLGLAFNWGALAGYSAIAGSCNWSIVAPLYLAGISWTMVYDTIYAHQDKRDDILVGVKSTALKFAEKSRIILSVFSGLVISGMFLTGIAANMPLFYYLGTAACSSHLIWQLKTVDFNNPSSCLEKFISNKNFGLYFLLIIIVSKLLQDKENENEIQKK", "function": "Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.", "AFDB_id": "AF-Q54U71-F1-model_v4" }, { "swissprot_id": "P42581", "sequence": "MPEPGPDASGTASAPPPQPPPQPPAPKESPFSIRNLLNGDHHRPPPKPQPPPRTLFAPASAAAAAAAAAAAAAKGALEGAAGFALSQVGDLAFPRFEIPAQRFALPAHYLERSPAWWYPYTLTPAGGHLPRPEASEKALLRDSSPASGTDRDSPEPLLKADPDHKELDSKSPDEIILEESDSEEGKKEGEAVPGAAGTTVGATTATPGSEDWKAGAESPEKKPACRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAAQRIVRVPILYHENSAAEGAAAAAGAPVPVSQPLLTFPHPVYYSHPVVSSVPLLRPV", "function": "Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS.", "AFDB_id": "AF-P42581-F1-model_v4" }, { "swissprot_id": "P22405", "sequence": "MSLERTPPYLQVVAALKAKIVSGELKHGDTLPSVRDLAAQYEISTATAQKVHRTLKAEGLAEAKQGSATTVSTRRTLHRTAADRLESALSTGRIYADGEYAVITSAALAEPPEWVADLLGTESGQAVRRERVTHSADDQPVSASVSWFSADLAETVPALLVRDRIIGGTPSAIEAATGRRAVATEEATTAAAATEDQAALLGVAAGAPVLLSRNVYVDAQGDTIEVGESVAPAGRWRVHRD", "function": "Controls plasmid transfer and prevents the lethal effects of the tra/kilA gene. Repressor for the transcription of certain pIJ101 promoters, including those the from kilA and kilB loci.", "AFDB_id": "AF-P22405-F1-model_v4" }, { "swissprot_id": "A9BHX3", "sequence": "MPNKKSAEKRVRQSEQRRQKNRGYQKRIKEISKEIDKKIHENAEREELMQLLSKSFKIIDTAKSHGAVHKNYAARKKSKLHLKVKKYLGEMAPESSPVNE", "function": "Binds directly to 16S ribosomal RNA.", "AFDB_id": "AF-A9BHX3-F1-model_v4" }, { "swissprot_id": "Q50900", "sequence": "MAERTYRINIAAELAGVRVELIRAWERRYGVLTPRRTPAGYRAYTDRDVAVLKQLKRLTDEGVAISEAAKLLPQLMEGLEAEVAGRGASQDARPHAETWRESMLAATQAYDQPRVSDVLDEVLAALPPLKAFDEVLAPLLCDVGERWESGTLTVAQEHLVSQMVRARLVSLLHAAPLGRHRHGVLACFPEEEHEMGLLGAALRLRHLGVRVTLLGQRVPAEDLGRAVLALRPDFVGLSTVASRSAEDFEDTLTRLRQALPRGLPVWVGGAAARSHQAVCERLAVHVFQGEEDWDRLAGT", "function": "Negative regulator of the carB operon in the dark. Binds specifically to the CarA operator, in the region around the carB promoter, which blocks access to the RNA polymerase.", "AFDB_id": "AF-Q50900-F1-model_v4" }, { "swissprot_id": "Q08925", "sequence": "MVVSYNNNNNNNNNNNNNNISNNNNNNNMFPPFPSSDDFAMYQQSSSSGPYQETYASGPQNFGDAVYPMNGNFTLLPSDFTREPNDSFFYENDGIFDYQRIQQQPTQFQTKQRNDSQQQRFSQEQNFEIDNEVVHNNNRYYEYERSSNEVSPFDDENPNVLSDGMSPTIMATATAVTNANAPLPVNAQANNPLNFTSAPSRTVYLGNVPPNLSVKELLDHVRSGVVEDVKIIPEKMCAFVSFIDESAALLFHSDAILKRLNIGDRDIKIGWGKPTRIDPIVAARISTDGATRNVYIGRMTIEGEESHLSEEQLRVDLEEYGEIDCIKIIKEKGIAFIHFASILNAIKVVTNLPIRNPYYQNKRIFYGKDRCAFITKTQQHNAAQFLGVQPGMEHMIEFSDREFISNALLQQSAAAAAIATSAGGPNNLGNRTVYLGSLPKDVKIEEICNAVRGGLLQSIKLLNDRYVCFVTFIDPTAAAQFYAMSSLYGFTVQKKRCKVGWGKHSGPLPNALALAVSNGASRNVYVGNIDFVGDSLRDERVFTESNLRHIFQQYGEVEQINFLPEKNCCFINYTNISNAILALDKIKSNPYFKDLKINFGKDRCGNVPHQSR", "function": "RNA-binding protein that binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES). Probably involved in translational regulation.", "AFDB_id": "AF-Q08925-F1-model_v4" }, { "swissprot_id": "Q9WYH1", "sequence": "MRLTVFLSLFLGVMVFGAFDQEAFLFVQHLTSENFESALNMCSNQVKAQLSVQSLSNIWNSLKAQLSDFREIAGYEKIIQAEYEIYNFTLKFDRGEISALVTMDREGKVAGLFFKQATKTEYELPDYVDPESFEEKDITVNGLPGKITIPKGSGPFPAVVLVHGSGPNDMDETIGPNKIFKDIAYGLSSKGIIVLRYHKRTFVEKVDPTTLTVEKEVIEDALEAVKILKERKDVSRVYVLGHSLGAMLTPEIAERSKADGVVMIAPPARPLEEVMEDQLKYLQSLGLASNVEETLNILEKLKRKEIPPDEFVLGAPAKYFYDLRERDPASIAKRLTIPMLLIFGGRDYQVTEKDQEIWLKELSGRENVKILVFDDLNHLMISGEGKSTPVEYMKKGHVDKRVIDEIARWMVK", "function": "Exhibits significant esterase activity with a preference for short acyl chain esters (C4-C8) in vitro. Its physiological function is not known. Displays neither proteolytic activity using casein as substrate, nor peptidase activity when assayed with L-leucine p-nitroanilide and L-proline p-nitroanilide.", "AFDB_id": "AF-Q9WYH1-F1-model_v4" }, { "swissprot_id": "T2KN67", "sequence": "MKHVIMLYFIAAATLFSSCAKQDSEHRLITVKNSLDLPRAFETIEISKSDIQLHTGERFEDFSIQDVATKAILTSQFVDEDQDGTADVLLFQPELNPNSEKQFELVKVDGGVEVDSTVYCYSRFVPERTDDYTWENNKVAFRTYGPVAQKMVEDSLPGGTLSSGIDAWLKKVEYSIIDNWYAKNDKDPGYYHIDHGEGLDNFHVGSSRGVGGSAVKVDTSYYISKNFTDYKTITTGPIRTSFILKYADWDANEKTISEEKHISLDYGNNFSRFEIHVDGTDELSVGLTLHDNKGEITQNVDQGWIAYWESEYFDSELGTAIVAPKGVMTASEYYVTSMKDRSNLYAQLNVDNNKVVYYAGFAWKESKQYPTKASWEKYIQEFSEKLNTPLEVSIQ", "function": "May be involved in ulvan degradation (Probable). Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall. It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable).", "AFDB_id": "AF-T2KN67-F1-model_v4" }, { "swissprot_id": "P27514", "sequence": "MKFSHSLQFNSVPEWSTKYLAYSQLKKLIYSLQKDKLYSNNKHHVVEPHDANDENLPLLADASPDDQFYISKFVAALNQELKKIDKFYISQETGLIANYNELKDDVMELENTNKATQLFNQQQQHQLQSVARNRKSKSQQRQRRFSSVSSTDSNPSLTDMSIDSAPVIHTQVSNTTNNGNSMQNLASASVSLSNSNPVYLSPFTQHRLSLKKRLISIYTQLSELKDFIELNQTGFSKICKKFDKSLNTNLKQNYLNYIKFHSHVFNPATINRIQHHITETILTYASLNKGTRRPSNTFNLDADRINNDENSSGNEEDEDGNRQEVLDFQDAERELSSHLRDHVVWERNTVWKDMMNLERKYQSAKTDNKKFSKLSSSQLRPNANITESMAMSSGGAGIIAPSTDSLTFRELMHLPPKQWLQFIMGQTSLLKFLLITSCFIALLTFNLTPFTQDSLQKNCFAILIYASLLWATETIPLFVTSLMIPLLIVVFPVIKDPITSQPMSPRDSSQFILSTMWSSVIMLLLGGFTLAAALSKYNIAKVLSTHILASAGTNPHFILLTNMFVALFVSMWVSNVAAPVLCYSIVQPLLRTLPRNCSYAKALILGIALASNIGGMSSPIASPQNIFSIGIMDPSPSWAEWFMIALPVCFICVMAIWVLLIITFPPEPNVKILQLHPSRDPFTLKQWFVTLVCIITIVLWCLSNQISGIFGEMGIISIIPIVVFFGTGLLTSDDFNNFMWTIVVLAMGGTTLGKAVSSSGLLSTMAQLIKAQVEHEPIFIIVLIFGLVILVMATFVSHTVAAMIIVPLMSEIGSNLPSGDHSRLLIVIAALLCSSAMGLPTSGFPNVTAISMIDEVGDRYLTVGTFITRGVPASLLSYAAIVTVGYGILKVMGF", "function": "Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol.", "AFDB_id": "AF-P27514-F1-model_v4" }, { "swissprot_id": "Q7X281", "sequence": "MKVACIGAGPGGLFFATLLKRSRPDAEVVVFERNRPDDTFGFGVVFSDATLDAIDAADPVLSEALEKHGRHWDDIEVRVHGERERVGGMGMAAVVRKTLLSLLQERARAEGVQMRFQDEVRDPAELDDFDLVVVCDGANSRFRTLFADDFGPTAEVASAKFIWFGTTYMFDGLTFVHQDGPHGVFAAHAYPISDSLSTFIVETDADSWARAGLDAFDPATPLGMSDEKTKSYLEDLFRAQIDGHPLVGNNSRWANFATRRARSWRSGKWVLLGDAAHTAHFSVGSGTKMAMEDAVALAETLGEASRSVPEALDLYEERRRPKVERIQNSARPSLSWWEHFGRYVRSFDAPTQFAFHFLTRSIPRGKLAVRDAAYVDRVDGWWLRHHEAGPLKTPFRVGPYRLPTRRVTVGDDLLTGTDGTGIPMVPFSGQPFGAGVWIDAPDTEEGLPLALDQVRETAEAGVLLVGVRGGTALTRVLVAEEARLAHSLPAAIVGAYDDDTATTLVLSGRADLVGGTK", "function": "Involved in the degradation of salicylate via a pathway involving coenzyme A derivative. Catalyzes the aromatic hydroxylation of salicylyl-CoA to yield gentisyl-CoA.", "AFDB_id": "AF-Q7X281-F1-model_v4" }, { "swissprot_id": "O94364", "sequence": "MKRGKCKEKDNGLKRISSESEVWNFLDVTVSELNKQKRSPGQTVSKRLHKKQRVVSNPDLSLPSSPVKQILRNGLQNSKYGSHKTGLERSASCSSIDASANHSSTTYREQRSYLMEEGLDTQPIVPREVSSGRELDSTNHTIGTERAFLIEEDVSEDDEIQMKSIHELRFAGEQQRIVDEIEYLVDGVTFSGNSSASRYLSLIGIAEKMFDNSFRLCLKSIRDVFLRIFEEIDPKDTLHTFLQIYIFATMANEMDCMSSLLDAYSNNVKLLLQTAITLEPQVPVSILAKSLPKSVKGAVQEFVIKAELTFSFSNESLASSDSISLAAIALMKTSSGVFAESELFTELINLLIEKSYPILKENDGSNNFLLHALCSSLEKFTDFQGSEKIQKVSQILSSKLQILIDEHNETNSPKIDDTVVHACSEKLLRTLIQTVNSNSDHALAVSKSEVPLFAYKILQKFSNFSSDDETTRELIILILGLLLGLVEESHEFIQTITHVEVSFGASALDVLISFYQKNESIVEISGYVVMILSHCFLNDPKAFAQLKPLISQFYESLHKFKNFHLKLKEELMMMGSNGLAIVSIIDELHKSLQDYLRSDLVK", "function": "Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin.", "AFDB_id": "AF-O94364-F1-model_v4" }, { "swissprot_id": "B0WPU9", "sequence": "MDSCQICMEIYESLIRWLRVLQLSAPHDNEKDLSDGVALAQALNQIAPEMFSDSWLSKIKSDVGHNWRLKVSNLKKIIEGVYVYYQDILSLNLAEELRPDAMKIAEKCDGFELGRLLQLILGCAVNCLEKQKYITQIMELEESLQRNIMAALQDIEYVWQGASPSRNSINAPSLDVKTLQEDRDSLAQKCHETNKKMLILIEEKSVLQQEISKLQVIIERYEHPNLIGDDGTSLGPIQLGSSRYNDLRKVVDGLKDELLQAETARDDLKMKSAMQEKEISDLQVKIDELHSATAEIAQLKDEIDILKEANDKLKICETQLQTYKKKLEDYNDLKKQIKMLEERSAEYLKQNSDFEEEAKKYAGLKGQVELYKKEIQDLHAKLDSEMGKTMKTEFEHNQLQAKLSAVQREKENLLSERDALREACDELKCGQAAEDSESGRNTMSKELHSNDVRERIERLERENKALREGQGGQTALSQLLDDANQRNDKLRDQLKSANQRIMLLSQNHSDEISSKSDMDIQLKQALELNEQRSSQIDEAQSQMGQLQAKIANLESALVAKEQDLLAADTRYKKCVEKAKEVIKTLDPRAVNEALLLEKPPQQDGSEGSSTTGGGDASTLTAASASSSSARAPMGVQEEQLIATAFYRLGMTCQREAVDSRLALLSGPGQSFLSRQRQPAPRKPMNMSYAKK", "function": "Involved in endocytic trafficking. Probably acts as a cytoskeletal linker protein that tethers endosome vesicles to the cytoskeleton.", "AFDB_id": "AF-B0WPU9-F1-model_v4" }, { "swissprot_id": "Q12749", "sequence": "MISTTISGKRPIEQVDDELLSLTAQQENEEQQQQRKRRRHQFAPMTQFNSNTLDEDSGFRSSSDVATADQDNFLEESPSGYIKKVILRNFMCHEHFELELGSRLNFIVGNNGSGKSAILTAITIGLGAKASETNRGSSLKDLIREGCYSAKIILHLDNSKYGAYQQGIFGNEIIVERIIKRDGPASFSLRSENGKEISNKKKDIQTVVDYFSVPVSNPMCFLSQDAARSFLTASTSQDKYSHFMKGTLLQEITENLLYASAIHDSAQENMALHLENLKSLKAEYEDAKKLLRELNQTSDLNERKMLLQAKSLWIDVAHNTDACKNLENEISGIQQKVDEVTEKIRNRQEKIERYTSDGTTIEAQIDAKVIYVNEKDSEHQNARELLRDVKSRFEKEKSNQAEAQSNIDQGRKKVDALNKTIAHLEEELTKEMGGDKDQMRQELEQLEKANEKLREVNNSLVVSLQDVKNEERDIQHERESELRTISRSIQNKKVELQNIAKGNDTFLMNFDRNMDRLLRTIEQRKNEFETPAIGPLGSLVTIRKGFEKWTRSIQRAISSSLNAFVVSNPKDNRLFRDIMRSCGIRSNIPIVTYCLSQFDYSKGRAHGNYPTIVDALEFSKPEIECLFVDLSRIERIVLIEDKNEARNFLQRNPVNVNMALSLRDRRSGFQLSGGYRLDTVTYQDKIRLKVNSSSDNGTQYLKDLIEQETKELQNIRDRYEEKLSEVRSRLKEIDGRLKSTKNEMRKTNFRMTELKMNVGKVVDTGILNSKINERKNQEQAIASYEAAKEELGLKIEQIAQEAQPIKEQYDSTKLALVEAQDELQQLKEDINSRQSKIQKYKDDTIYYEDKKKVYLENIKKIEVNVAALKEGIQRQIQNACAFCSKERIENVDLPDTQEEIKRELDKVSRMIQKAEKSLGLSQEEVIALFEKCRNKYKEGQKKYMEIDEALNRLHNSLKARDQNYKNAEKGTCFDADMDFRASLKVRKFSGNLSFIKDTKSLEIYILTTNDEKARNVDTLSGGEKSFSQMALLLATWKPMRSRIIALDEFDVFMDQVNRKIGTTLIVKKLKDIARTQTIIITPQDIGKIADIDSSGVSIHRMRDPERQNNSNFYN", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Probably plays a role in structure.", "AFDB_id": "AF-Q12749-F1-model_v4" }, { "swissprot_id": "Q5H7C3", "sequence": "MSDQFTSIQWDRTEPEGDVPGDSNDHSQVQINSSINLIEEDQGQEQEQDDLVTTNTVVRGGNDSDSNPNEQIPPRDVYIRSKVSQPLKESDGQNFYISYLIETETNEPGLAKTKLKVRRRFSDSNFLYNCLANDFPTSIIPPLPNKQRLEYIKGDRFGEYFTTKRSIALNNFLNRISKHPLLKQAKIYHIFLEDSVNWNTFKQNLKISSNPNSTVGGGSTTSANANGELDSFSDYIMNAFKKPTYESENAKEFQEITDKSNKLQENINKIDKIYQRVVKRQSEISEDFRLFGDEFKKLNQILTEGSDTQFDKELSQQFTSFSENIYQISYDSFKLTRQVDLHYLTSLKDLDHYISQIKNMIKFKDSKLLDYEMLQNYLNKAIAEKNHLMNGNNVSGSDGAMNFISKKIGSLRGKTPGQTYSSGNETNDRINKLNEKIEFLEREVKETFELFHTFEKNLITEYQLFDRIKNDEITTNLHELSQYYLDYYNSVVNHWNDVEIPHSEHLTDELHVLQQSQLRKNLENISIDPKLDVNSKLFEHDDVRLNNDHIRSDLRSIKSQERKNEQVHKQDQEQGEEQEHEQDQVQNQEQEQEPEELSREEAEVLETPVQAQEQEQQEPEELHASQTESHTQSEPQNDNQHNFDDDGSDEGLVDVEGLEQW", "function": "Required for glucose-induced micropexophagy and ethanol-induced macropexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells.", "AFDB_id": "AF-Q5H7C3-F1-model_v4" }, { "swissprot_id": "Q9FHK0", "sequence": "MSVSDEEDECFARFLESEVSSVEDKEETKEPEAKRQRIEKGETKALEKDEDQKENGNKDKTDAKRIESGVFTNVPTELFRHILKFLSSEDLVSCSLVCKFLNFAAADESLWRRLYCIRWGLTLPSRKLRESAWKKLYIDRDEQDMIELVRTCPSDFKEYYVHMQAAKRSQAPLPSQMVDDRIILDNTVLEQVSLWKKSKGLTDKAVTGHICLGTKCSYHQIDDVFICKETGNVHVCDDNCKEVILSPEGDLMVCTISGVCSDTLLVQTEPDADGCYEEEAELEAEVFTDKSRLARAFELGYNCDDEQELERTLRFC", "function": "Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q9FHK0-F1-model_v4" }, { "swissprot_id": "Q05561", "sequence": "MTVAVTNIRVEDKLYQNRYVVDAGRPHIRVRPHDWPSVNLYALTSVCPAKCYELNDQGQVEVIADGCMECGTCRVLCEASGDIEWNYPRGGFGVLFKFG", "function": "Could be a 3Fe-4S cluster-containing protein.", "AFDB_id": "AF-Q05561-F1-model_v4" }, { "swissprot_id": "Q7UXK9", "sequence": "MCSWRCAAARSHASANRCTPKERLGRQENRSAHCPGTIRSIRMEWSRWERQEFRCKRSFQRLGSSCEQFSPPMQNRRWEIERLPWRFSPVGKPFHFRDNVRAMRYVELHCRSNFSFLDGASHPDELVQRAAELGYEGLAITDRESIAGVVRGFSPAQELGLQYIVGTEVHPTDAPPMVLWPTDRAAYGRMCRMLSTGRMRCEKGRCELSFEDIAEHAQGILAGVIATDESRSIEDQHAHVNDSRQFLRGPFRDVFDDRGYLLASFHRGVDDAAKATWLRNLSLATDVPLLACGDVRYHSAERMALHDCVVAISQGKSVEQIQSDRLVNSQHHLRSLEEIAELYRDVPDAVARTIEVAQRCTFTLDQLKYEYPVELAPEGMTPIEHLKRLTWEGARGRWPNGVPEKVIETLRHEVTLIEDLQYEAYFLTVWDLVRFARSQEILCQGRGSAANSVVCYCLGITSVDPTHTDLLFERFISRERGEAPDIDVDFEHQRREEVLQYLYEKYGRDRAGMTAVVTCYRAKSAIREVGKALAISPDIIDAVAKLAGSYSRNPELPERCRDAGLDPDTPLGRRFLYLTETLIGFPRHLSQHVGGMVMTAGSLCELCVTENAAMPGRSVIQWNKDDLDDIGILKVDILALGMLSAIRRCFELVKDHHNRELSLSTIPPDDTPTYDMICAADTMGVFQIESRAQMSMLPRLKPRCYYDLVIEVAIVRPGPIQGNMVHPFLAARENPAAAKYPNDAIRKVLEKTLGVPIFQEQAMKLAVVAAGFTPGEADQLRRAMAAWRRPGVIDRFRTKLLEGMKANGLNGEFAENVFRQIRGFGEYGFPESHAASFALLVYASCYLKRHYPTAFCAALLDSQPMGFYAPAQLIRDAQQHGVQVLPVDINDSNIRSKLIPDLNRPHPKLRLGLQMVRGLPSAVAQKIIVARDANGPFANLHDLTTRAKLSRSNIATLADADALASIAQDRRAAVWQSLAQDDSGDSMPLLADLEPDCSVPEELVPMSPAEEVKNDYATTGLSLKAHPVSFWRDDLNALRCKRASDLPKLRDGVHVRVAGLVLMRQRPGTAKGITFVTMEDETGSMNLVLFAQVWKRFFKIARGSDAWIVDGKLENKKGVIHVIVGRVEDLSEKASGLKVPRRDFR", "function": "DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.", "AFDB_id": "AF-Q7UXK9-F1-model_v4" }, { "swissprot_id": "Q3U0K8", "sequence": "MNGKRPADPGPARPMKKGKKQVSAEFSDAVTEEILRKQVAEAWSCRTPFSHEAIALDMDPFLHCVIPNFIQSQDFLEGLHKELLSLDFHEKYNDLYKFQQSDDLKNRKEPHISALRKLMFEDFRAWLSKVSGIDLEPTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPSWDRDLGGTLDLYDTDEHLQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEETSRLSISGWFYGPSLTRPPTYFEPPIPRNPHIPQDHEILYEWINPAYLEMDYQMQIQEEFEERSEILLKEFLKPEKFAEVCEALEKGDVEWKSHGPPNKRFYEKAEENNLPDVLKECMGLFRSEALFLLLSNLTGLKLHFLAPSEDDETEEKGEGETASAAAGTEEGTSRRPSGPENNQVAAGSHSQENGEQADPEAQEEEAKKESSVPMCQGELRRWKTGHYTLVHDNTKTEFALDLFLYCGCEGWEPEYGGFTSYIAKGEDEELLIVNPENNSLALVYRDRETLRFVKHINHRSLEQSKAFPSRSGFWDFAFIYYE", "function": "Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.", "AFDB_id": "AF-Q3U0K8-F1-model_v4" }, { "swissprot_id": "Q1QDP2", "sequence": "MSDFVNDGHTTPEAFVQHIKSLGRYDFPEPAIVDPEGMGIVAIGGDLAPETLISAYAQGLFPWFNDDEPIAWWCPEPRCVMQPTDYQPSKSLRKLANRSRWQLTLNQAFDEVIHACSLPRSNGVNNDLNESQPVGEHTWIHDEMIEAYTELHAQGFAHSIEVWDDKGALVGGLYGLKIGGIYFGESMFHIASNASKLAFWGLMRLCEHSNVNLVDCQLPNDHLMSLGAITLSRTEFLTQLDILISNSSDNWHKNSHKPLAVPLLGSLQPWQLNL", "function": "Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.", "AFDB_id": "AF-Q1QDP2-F1-model_v4" }, { "swissprot_id": "Q3J2P2", "sequence": "MRPIPALALTFSLVAMPALAQDARQIERMIEGRHGLMTLMAHELGKLGGMAKEETPYDAEVAGKAASNLSALASVISPELFPKGSAVGEAEDSEALPAIWEKPDDFAQKISGMEEAAAKMQAAAGTDLASLQGAMRDLGAACGSCHETYRQKD", "function": "Monoheme c-type cytochrome, that is particularly expressed when cells generate energy via aerobic respiration.", "AFDB_id": "AF-Q3J2P2-F1-model_v4" }, { "swissprot_id": "Q8WXI2", "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV", "function": "May function as an adapter protein or regulator of Ras signaling pathways.", "AFDB_id": "AF-Q8WXI2-F1-model_v4" }, { "swissprot_id": "Q8VY09", "sequence": "MGSLGYSISMIASLSPTLMESRLISSMGCVSMTVAPSFSSVSVVSSSLGTTRRDRTLKLRSSMSPGMVTTLDSDVGVGSSATTKKVLVPIGYGTEEIEAVVLVDVLRRAGADVTVASVEQKLEVEGSSGTRLLADVLISKCADQVYDLVALPGGMPGAVRLRDCEILEKIMKRQAEDKRLYGAISMAPAITLLPWGLLTRKRTTGHPAFFGKLPTFWAVKTNIQISGELTTSRGPGTSFQFALSLAEQLFGETTAKSIEEFLLLRDGYQNPKNKEFNSIDWSLDHTPRVLIPVANGSEAVELVSIADVLRRAKVDVTVSSVERSLRITAFQGTKIITDKLIGEAAESSYDLIILPGGHTGSERLQKSKILKKLLREQHESGRIYGATNSSSTVLHKHGLLKEKRTTVYPSESDEPMNQQMIEGAEVVIDGNVITSLGLATVTKFSLAIVSKLFGHARARSVSEGLVHEYPRQ", "function": "Plays an essential role in chloroplast development and is required for chloroplast integrity and viability.", "AFDB_id": "AF-Q8VY09-F1-model_v4" }, { "swissprot_id": "Q4PLW0", "sequence": "MASVAVESQPSVVTRVANLPLVSSTYDLVSSAYISTKDQYPYLKSLCEMAEKGVKTITSVAMSGALPIIQKLEPQIAIANTYACKGLDRIEEKLPILNQPTNQVVANAKGAVTGAKDAMTTTVTGAKDCVASTITEVVDKTKEAVTGSVEKTKSVVNGSINTVLGGRMMQLVSSGVEKAFTKSELLVDQYLPLTEEELEKEAKKVEGFDMVQKPSYYIRLGSLSTKLRSRAYQQALTRVKEVKQKSQETISQLHSTVNLIEFARKNVHNANQKIQGTQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLVSNIQGLPQNIHDQANHLGVMAGDIYSVFHNASSFKEMSDGLLSSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQDAQSRGAENTTSPETQQPETKRIKPAPASSAWGSQSGDTSCTVATC", "function": "Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.", "AFDB_id": "AF-Q4PLW0-F1-model_v4" }, { "swissprot_id": "P23487", "sequence": "MCNALCECLKCPGKVVCCCCSCACKMLLSIVFSALLMVVVIGLIVYFTVFYHKDKNTDEVQKQVAQLTPIVKRSIRDYFNKEY", "function": "Involved in morphogenesis and development.", "AFDB_id": "AF-P23487-F1-model_v4" }, { "swissprot_id": "O24766", "sequence": "MKTYRIGQIVPSSNTTMETEIPAMLQARYAEFPEERFTFHSSRMRMMHVNPEELKAMDIASDRCAVELSDARMSVMAYACLVAIMAQGDGYHRVSQARLQNTVKENGVEIPVLSSAGALVDTLKEFGYKKVSIITPYMKPLTKRVADYIEAEGIEVQDSISLEVSDNLEVGLLNPENLLEHVKRLNHDGVDAVILSACVQMPSLPAIQRAQDQIGKPVLSAAVWTVYQMLKNLGLETRVPNAGHILSGVKPQA", "function": "Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.", "AFDB_id": "AF-O24766-F1-model_v4" }, { "swissprot_id": "W0TCD0", "sequence": "MTSWLPQNLQKRLLLYTIKQVSLFSNVDVSNLDVSIGSQSHFGFTDIDLNVCEINLPNIEVLSGRISKLNLQLAVAGNVEISGEGMVFVLKPADGFFDDDSSEQWASSLTKSVMDMTKSILDTELSEYQSKIYKDTNEDIKPPTALDSMMDKVLRVALSKLTINLKNVELQLIISPELMLKISISEVKMISADEKRIADVIGVSAVFSKPEQSVPSYGSSSSDKEDDNTSDSEDPLSTSITYSKLEATSIYLSAMESLVLDSLDGETYQFLNIDKIEVQFQGITSINDLKVHDLKIKINALDIHLENVSSILSHIMSLLNHVQLSNSEDKIRTQELKSYKRFQHEQNIEEDKTLTFVLLNSLKFHLRDNLFIMLTEISLNSSVSPYTSVSISDIQLVLDSKEYINRSDSSEPFLSLNKNSSTSEQKLHLNRDIKVEVDYSLMKQLILFANDYMCLYNQIIERPSTYADPSADPKFLLSSQNVCFLLNLGDLIMEFHFSPFFSNIPHTTFKIPKLSIFSVQNNEKSHIGELTDFEFHSRKSGCFNISGANSKFCASNVNTKTKATLENLEVSILESDMNKIIQCLSGVLGSLPELLLSSGETTSSKNMEKRSVRMMQSSAFLHNRTALSMFCVQINCMKIKISNISGKAFGDLMITARKSLIYQDKYSDLSISFTEFTAQRQYRSEKTDIIFDINHDSNIANFVINRTKVGKIKAYLTGVGIFIHTKWSELFSGQKTENSINEQKKNAKTLVSIPIDIKLYDCALSLKPCRLSTGLAINIPRAQINITKNEITLSTKILDLLLIDDMNLIHETDLGHTTSTSNWYEKQGYSSLVKIDTLSVRFCPGGVASTRVNVHKIDSSICSDSFNALIQTIIDLKPVVTYPENVKYQLEPELVSVFEDLTDQYFTTARISENDLEIYPDTYSNSGESLVFEENYFSPKLESPSKNEVNMAVFEILSNVKISVDEIKLKLYDGYDWKHTRKEINSAVEQLEENFKDGLSCPDAKVFDSIYIPAPRDEDENIKSNINMKIHNEETKEGKMKLRPTKKYKILIQGNGIKVNIQSGNDELRTTSTLPLSDNTYDILNETSVQINNLEIVDNLPTSTWNKFLTRTKLKTTNTLQQSPMFSLRFTMIRPTPHLYATELIFSVHVKPISLHVDQDALEFLTLFFQFKDPRFELIDDYPDIPYIQRFEINSVKILLDYKPKKVDYVGLRSGKTKEFMNFFILDQAKINLKHVILYGIDGFSRLETILTDIWTPDITKTQLPGILGALTPFKPFAGLSYGARALVSVPTEQYQQSGRLGTSLQKGGMVFLRTTGGEFVKLAVRLTSGTQTILESTEKLLGGQGSNGRNIKIKLVEGDEIVDAFIDESILRSTTLFDNTANDNNHLDVILPQGDTQKVISLYADQPKDFYSGLHDAYSSFGRNLNITFDSMKQAKNDIKTANGAQEAVSTVAKAAPLALIRPLIGVTEALSKTLQGLNNQYDQEEIAHIEEKYKSSN", "function": "Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.", "AFDB_id": "AF-W0TCD0-F1-model_v4" }, { "swissprot_id": "Q7XR60", "sequence": "MAAAAAEQQQQGFRPLDEASLVAYIKATPALAARLGGRLDALTIKEVGDGNLNFVYIVLSDAGSLVIKQALPYIRLVGDSWPMSRERAYFEASALQKHRALCPDHVPEVYHFDRAMSLIGMRYIEPPHIILRKGLVAGVEYPLLAEHMADYMAKTLFFTSLLYNSTTDHKKGVAQYCDNVEMSRLTEQVVFSDPYRVAKYNRCTSPFLDNDAAAVREDAELKLEIAELKSMFIERAQAFLHGDLHTSSIMVTPDSTQVIDPEFAFYGPMGYDIGAFLGNLILAYFSQDGHADQANDRKAYKKWILKTIEDSWNFFHKKFVELWNKHKDGNGEAYLPPIYNSSELLSLVQKKYMTSLFHDSLGFGSAKMIRRIVGIAHVEDFESIEDASKRASCERRALNCAKAILKGRRQFESIEQVIVHVQSFDRD", "function": "Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.", "AFDB_id": "AF-Q7XR60-F1-model_v4" }, { "swissprot_id": "Q46731", "sequence": "MITSALHRAADWAKSVFSSAALGDPRRTARLVNVAAQLAKYSGKSITISSEGSEAMQEGAYRFIRNPNVSAEAIRKAGAMQTVKLAQEFPELLAIEDTTSLSYRHQVAEELGKLGSIQDKSRGWWVHSVLLLEATTFRTVGLLHQEWWMRPDDPADADEKESGKWLAAAATSRLRMGSMMSNVIAVCDREADIHAYLQDKLAHNERFVVRSKHPRKDVESGLYLYDHLKNQPELGGYQISIPQKGVVDKRGKRKNRPARKASLSLRSGRITLKQGNITLNAVLAEEINPPKGETPLKWLLLTSEPVESLAQALRVIDIYTHRWRIEEFHKAWKTGAGAERQRMEEPDNLERMVSILSFVAVRLLQLRESFTLPQALRAQGLLKEAEHVESQSAETVLTPDECQLLGYLDKGKRKRKEKAGSLQWAYMAIARLGGFMDSKRTGIASWGALWEGWEALQSKLDGFLAAKDLMAQGIKI", "function": "Mediates transposition of transposon Tn5 by a 'cut and paste' mechanism. First, the monomeric transposase binds the 19 bp inverted DNA repeats flanking the transposon. Then, dimerization of the DNA-bound transposase creates a synaptic DNA complex. After nicking of the first DNA strand, excision of the transposon proceeds through a series of intermediates. The transposase then mediates the insertion of the transposon at a new site by strand transfer. The activity of the wild-type transposase is very low, and is further inhibited by dimerization with the transposase inhibitor (inh).", "AFDB_id": "AF-Q46731-F1-model_v4" }, { "swissprot_id": "A9FU01", "sequence": "MRPVPGPSVFWGAGSRLPAPLVARAHRLLRTRRANPARGASRITKDMNYWDYIHVEELLALQGGFDDDEQKVGNDEALFIVVHQIYELWFKLILRELTSARELFRQNPVPDQKLASAARSFRRVVTIFEQAIEHFRVMETLTTRDYLDFRDRLIPASGFQSAQLREIELLLGLDDALRIPLGREGSYKEALKTADGAPSAATRRVEARLASGPSLKHFLDEWLSRTPIDGSSEPEGVVGFLRSYTRSMRQENERRVQMAIDKALTPPDVERLRARYEAESAAAEAFLLAEDDPAADAATREKRRAVRAAIVFIESYRELPRLAWPREVLDRILEMEQAMLIWRQRHARMVERVIGRRTGTGGSAGVDYLDQTALRYRVFGDLWTVRSLLLRKPSVPEIEHASDYGFRVEDSP", "function": "Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.", "AFDB_id": "AF-A9FU01-F1-model_v4" }, { "swissprot_id": "Q9VRI9", "sequence": "MIAVFSLIAAALAVGSLVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGTYLRFVKNSL", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9VRI9-F1-model_v4" }, { "swissprot_id": "P0A3I6", "sequence": "MLPSAQAPSLLNPTDDFAALGNIAWLWMNSPMHRDWPVHLLARNTLAPIQLGQYILLRCNDVPVAYCSWALMDADTELSYVMAPSSLGGNAWNCGDRLWIIDWIAPFSRDDNRALRRALAERHPDSVGRSLRVRRGGDTARVKEYRGRALDAAAARAQLDRYHAELIAGLRASNGGYAPRGRGTA", "function": "Protein-lysine palmitoyltransferase that catalyzes palmitoylation of the protoxin (CyaA) at two internal lysine residues, thereby converting it to the active toxin.", "AFDB_id": "AF-P0A3I6-F1-model_v4" }, { "swissprot_id": "Q6W2J0", "sequence": "MADAADSSMALVHSSLADSVLTSPRTLRQGQKWEVEYARYFGTPRRDPTAAPPSGLRYIMRGVHRHQGTWIPASCPASLCVCHPSLPSAVPVLTISIGDVVFEEHFVSILNFSWPQVTCVTQCPIRGSRVVFVSFCDKFKQIQKFAVRFPQPCDAESFLSCVECSCGSSGTMDIIPFGSDYVCEDSSASEYIVSNGLHHRLDDASNLEEQCFDHTIDEPPMNYHEETDQHVLEPLSASNTSNNSAFPPSFNQMLKSCSIDYDQEEPCPLAASNHVLQEVYVLDTSHDVANEERTAGKGMDAAEGVDASILTYDLMARIKTYMADESFNDMLLKLDKAIDELGGDMSL", "function": "Required for accurate chromosome segregation in meiosis. Required for pairing to occur between homologous chromosomes. Acts in early recombination steps and ensures pairing fidelity and proper repair of meiotic DNA double-strand-breaks. Regulates recombination and pairing of homologous chromosomes during meiotic prophase by controlling transport of RAD50 from cytoplasm to the nucleus. May affect pairing of the gene-rich fraction of the genome rather than preventing pairing between repetitive DNA elements.", "AFDB_id": "AF-Q6W2J0-F1-model_v4" }, { "swissprot_id": "Q9SZL8", "sequence": "MMDNEVLDFDIGVGVSSGGDVDDDAIDIEHHALDDDDMLDSPIMPCGNGLVGNSGNYFPNQEEEACDLLDLEPYDGLEFESEEAAKAFYNSYARRIGFSTRVSSSRRSRRDGAIIQRQFVCAKEGFRNMNEKRTKDREIKRPRTITRVGCKASLSVKMQDSGKWLVSGFVKDHNHELVPPDQVHCLRSHRQISGPAKTLIDTLQAAGMGPRRIMSALIKEYGGISKVGFTEVDCRNYMRNNRQKSIEGEIQLLLDYLRQMNADNPNFFYSVQGSEDQSVGNVFWADPKAIMDFTHFGDTVTFDTTYRSNRYRLPFAPFTGVNHHGQPILFGCAFIINETEASFVWLFNTWLAAMSAHPPVSITTDHDAVIRAAIMHVFPGARHRFCKWHILKKCQEKLSHVFLKHPSFESDFHKCVNLTESVEDFERCWFSLLDKYELRDHEWLQAIYSDRRQWVPVYLRDTFFADMSLTHRSDSINSYFDGYINASTNLSQFFKLYEKALESRLEKEVKADYDTMNSPPVLKTPSPMEKQASELYTRKLFMRFQEELVGTLTFMASKADDDGDLVTYQVAKYGEAHKAHFVKFNVLEMRANCSCQMFEFSGIICRHILAVFRVTNLLTLPPYYILKRWTRNAKSSVIFDDYNLHAYANYLESHTVRYNTLRHKASNFVQEAGKSLYTCDVAVVALQEAAKTVSLAMNKEVRRTMANRHFKASSVTGGKHQQEVLAQPEPEDEMDKKINQLRNELELANRKCEAYRTNLLSVLKEMEDQKLQVSIKVQNIKISLKDNL", "function": "Putative transcription activator involved in regulating light control of development.", "AFDB_id": "AF-Q9SZL8-F1-model_v4" }, { "swissprot_id": "Q7MQ42", "sequence": "MQKSLLAIAMASLLTPISYLHAQEVQTNDTVVVTANRFEQVESSVLASISVVTKAEIEQLNVTTALDILKTLPGVEVNSQGGKGQISSIFLRGTSSKHTLVLVDGVKINSATAGGASLGLIPAFAIEQIEVVRGPRAAIYGSDAIGGVIHIKTIPANRQTKHDANLGYGNDDHSSLAWRSSGQLNDSTQASFVFSDEKSDGYRVNEVAPSGDSHGYQSQTLFGSLRHEIDDAWSVQFNGYQLSSDVEYANQFSGVKNESNTDFYSIAGSLNFHKDNYSSQLMVSRSDNESWDGVASGMVAKTALFSSRNSVSWLNHWVVVPALTLAAGVDYDQENARQGGANATNYSKTEKDNKAAYVTAHFSKNIVTAEASIRSDDDSAFGKHNTWNLGLGIAPSDYVEFIASTGTGFKAPTFNDLYWPSSGNPNLKPETSKSSEVGIRSYLPFVQIDISAYRNEIEDMIDWAPTGPGGAWTPSNIDNAKIEGIEIEALFETGVIEHRVSAEWKDPRDKSDDSFLIRRARENFSWVSTYSADRFGFSAVANYVGDRKDSTGKTMDAYTLLDISANYKMTEALTLGARVGNLFDKEYQTAHSSGGKYYVGEGRNWFATVNYRF", "function": "Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.", "AFDB_id": "AF-Q7MQ42-F1-model_v4" }, { "swissprot_id": "Q9LVC3", "sequence": "MDQRRGNELDEFEKLLGEIPKVTSGNDYNHFPICLSSSRSQSIKKVDQYLPDDRAFTTSFSEANLHFGIPNHTPESPHPLFINPSYHSPSNSPCVYDKFDSRKLDPVMFRKLQQVGYLPNLSSGISPAQRQHYLPHSQPLSHYQSPMTWRDIEEENFQRLKLQEEQYLSINPHFLHLQSMDTVPRQDHFDYRRAEQSNRNLFWNGEDGNESVRKMCYPEKILMRSQMDLNTAKVIKYGAGDESQNGRLWLQNQLNEDLTMSLNNLSLQPQKYNSIAEARGKIYYLAKDQHGCRFLQRIFSEKDGNDIEMIFNEIIDYISELMMDPFGNYLVQKLLEVCNEDQRMQIVHSITRKPGLLIKISCDMHGTRAVQKIVETAKREEEISIIISALKHGIVHLIKNVNGNHVVQRCLQYLLPYCGKFLFEAAITHCVELATDRHGCCVLQKCLGYSEGEQKQHLVSEIASNALLLSQDPFGNYVLQYVFELQLQWATFEILEQLEGNYTELSMQKCSSNVVEKCLKLADDKHRARIIRELINYGRLDQVMLDPYGNYVIQAALKQSKGNVHALLVDAIKLNISSLRTNPYGKKVLSALSSKK", "function": "Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.", "AFDB_id": "AF-Q9LVC3-F1-model_v4" }, { "swissprot_id": "P75049", "sequence": "MEQVELIPQWYVAPVSVKDEAVVRNLKAKVKALGFDNEILDVRVLKEREVIEEVFSLKSGKLPRSLKNTAFTKWFVLDEDRYLKVKISEKNLLGRYIYIKMIYSEDAWRIIRNFPGITGIVGSSGRGALPTPLDQADADNLEQMLKGISVNPKKRVLVTNTAIVEMDADKFDEKCQYILKHKQVKPEAIAQVNESGEIIDTNQFAQALMEANKAEQDEWNEDVAIVKSEANKVDPSVLIPYLGKYEIVEGDTKVDQLQQFSVGNLVEVHLTGAIHIQGQIKALYQGTINKAVVEVELTTKTQLINLPLENLSFIEVEQSH", "function": "Participates in transcription elongation, termination and antitermination.", "AFDB_id": "AF-P75049-F1-model_v4" }, { "swissprot_id": "B7JBP8", "sequence": "MAHVVILGAGTGGMPAAYEMKEALGSGHEVTLISANDYFQFVPSNPWVGVGWKERDDIAFPIRHYVERKGIHFIAQSAEQIDAEAQNITLADGNTVHYDYLMIATGPKLAFENVPGSDPHEGPVQSICTVDHAERAFAEYQALLREPGPIVIGAMAGASCFGPAYEYAMIVASDLKKRGMRDKIPSFTFITSEPYIGHLGIQGVGDSKGILTKGLKEEGIEAYTNCKVTKVEDNKMYVTQVDEKGETIKEMVLPVKFGMMIPAFKGVPAVAGVEGLCNPGGFVLVDEHQRSKKYANIFAAGIAIAIPPVETTPVPTGAPKTGYMIESMVSAAVHNIKADLEGRKGEQTMGTWNAVCFADMGDRGAAFIALPQLKPRKVDVFAYGRWVHLAKVAFEKYFIRKMKMGVSEPFYEKVLFKMMGITRLKEEDTHRKAS", "function": "Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.", "AFDB_id": "AF-B7JBP8-F1-model_v4" }, { "swissprot_id": "P95357", "sequence": "MSIIHYFSLHVESARSALKQLLRQPFGTLLTLIMLAVAMTLPLFMYLGIQSGQSVLGKLNESPQITVYMETAAAQSDSDTVRSLLTRDKRLDNIRFIGKEDGLAELQSNLDQNLISMLDGNPLPDVFIVTPDPATTPAQMQAIYRDITKLPMVESASMDTEWVQTLYQINEFIRKILWFLSLTLGMAFVLVAHNTIRLQILSRKEEIEITKLLGAPASFIRRPFLYQAMWQSIFSAAVSLGLCGWLLSAVRPLVDAIFKPYGLNIGWRFFYVGELGLVFGFVIALGVFGAWLATTQHLLCFKAKK", "function": "Part of the ABC transporter FtsEX involved in cellular division.", "AFDB_id": "AF-P95357-F1-model_v4" }, { "swissprot_id": "P83606", "sequence": "VDFETYCKPTYDSGPCKGYFPRWWFNVKTGQCEEFIYGGCQGNKNNHVTRKECETRCLRKQLSRLHFSPPVDQYPYGDTERSNEEVPEYPPVHLNDSLEVSAVMNQRPLRNYTKQHKPNVTSDFSAISLTSGVDFETYCKPTHDRGPCKAYIPRWWFNVKTGQCEQFIYGGCQGNKNNYETKSICETNCLRRQLSELGVSADVHYRKHWNETKYSPNVTVEYPAVHFNVTLNPVCNEPKYPELCKGYFPRYYYNSRSKTCKKFIYGGCQSNGNNFLTLEECENTCLVDLQV", "function": "Inhibits trypsin and plasmin. Does not inhibit human plasma kallikrein, chymotrypsin, human neutrophil elastase, factor Xa, factor XIIa or thrombin.", "AFDB_id": "AF-P83606-F1-model_v4" }, { "swissprot_id": "Q9WZF6", "sequence": "MIVGVGIDVLEVERVPEKFAERILGESEKRLFLTRKRRREFIAGRFALKEAFFKALGTGLNGHSFTDVEFLESNGKPVLCVHKDFGFFNYAHVSLSHDRFAVALVVLEKRKGDIIVEGDESFLRKRFEVLERSVEGWEIETSLPPFTLKKLLESSGCRLVRYGNILIGE", "function": "Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.", "AFDB_id": "AF-Q9WZF6-F1-model_v4" }, { "swissprot_id": "Q2HA12", "sequence": "MEFCDESYDLVNIDEFDALWVASRHGVAFGVPPCLLISDDDAIARSSIELKSGPSSSNLSPSTLSTEKTSSDSSGVICDPQLHETWREGLGKFPAKEHARKVARELGADHGIIFLLGQDEKYYEDSDMGPTFRQRRYFYYITGADFPGCAVTYDILRDKLVLWIPRIEPRTVLWFGKVPTPEECKAASDVDSVYYIDFLHEKQCPVFKRGQTIHVLHPDQIPPELDHLGKFIRIDAVRLKPAMDAARVIKTDYEIALIRRANAVSSAAHKAVLRNIKRFTNEREIDALFRGYCIAHGAPIQSYPVIAASGINASTLHYDDNNQSLKNRQLLILDAGAEVHCYASDITRTIPLPGSFTPLAREIYRLVERMQDECIAQIKPGVRFSALHAHACAVAVTGLLKLGILRGEEEEILARGTVAAFFPHGLGHHVGLEVHDVSGTERLLLNGGPGSGPGSGGGYGCGASTWRGYRLRRRVMTKRESLTPWEVAALWEGAKPEKEKQQERWLLNNVPLDEVEAALTLASSSGARGQKLAPGMVVTVEPGIYFLPRVLEKYWNVGGVRIEDDILVTKKGYENLTTAPKGDEMMKCMGESGLL", "function": "Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.", "AFDB_id": "AF-Q2HA12-F1-model_v4" }, { "swissprot_id": "Q9NWH9", "sequence": "MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSGSGFKPFKGGPPRRF", "function": "When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.", "AFDB_id": "AF-Q9NWH9-F1-model_v4" }, { "swissprot_id": "O94719", "sequence": "MTPPSSSSHFPSPSSANNDFHSLSLEAHGSLSDKFISQFRLNYTIIPIAQKSNISLPFLTLSPCSFTICSLRARLHSLHGPSTVFLKRETSQISARVNDENGFTASPSFFSVDCFDELFPTLSTTDEQPKEPSIISISSSSSDPSSSPPPSSSLLKTPDNDFCARPETFVKSDTADIKLQIHQNNLVLTFLDTTTVSKVNIVLEIHIPVLRDFVTFEQYIPLMFLPSPFETILSFDNLKSDSPSSDLHLGWDHTVSKESMSQSIAEVLNPYNKGVSRSLNDATNMETYHWSPFPPQFSTFNDNALRLRIYYKPKSWLPKNSSCSLSVDVKATLLETTPPSCEVSYNLLLTCRSSNRFRLFPASTPNSNGLCRNDSKCRFLMILPETIIKSPSSFIGDSYNIANIDPPSSMNVQSSEFRVGEVQSFTTNTSSFAFTFKEIVQLGSKASVPMILFPAPSNYKLTIEKPPFPCDLTIPHTAINDSWLPMKLKETNAISYYRKTCSSCKYPFQFFINKLPFYQSPSLPLSATYVWIASALLSVQPGNGSFNIMLSLKFVSSMKPGTELLTIKQPKSSLLNWGLVNGYPKTEGRIVLLPRNDIVLIQADQPTSVFDLCWTIKPTYEKSSNFSCLQLPIPVLNTPILTPVTINIQSTTYYLIGYANQNSKKTLDQPTSLLVLGCKAKNVSELILSYLPEKPIPDGAPIVTNVVETNKTNEAPSSFRKCLQQFLVFLTFTGMTLFILYQLTFPYGVAKDNSSFIDTPLPHSCEMEKSLNVLQHKVLQLQAVNMKLHDYYEKEPTEIYKTVSVTSTQIMPAVTKMSSFELEREQFHKAFGFLRLNRKKDDNAN", "function": "Has a role in meiosis.", "AFDB_id": "AF-O94719-F1-model_v4" }, { "swissprot_id": "P11460", "sequence": "MFKSTLNIAVAIVCSSLVTLTGCEPKVAQSQVIQPLETPIVIEHNLGQTVISNRPQRVAALDMNEVDFLDQLNVPIAGMVKDFVPHFLEKYKNTPDISDLGAIVQPNMEKIYALKPDLVLMTPLHANQYEELSKLAPTVHFDIDFRNSHGHHVDIIKQHVIDLGEIFNKQTLAQKKVAEIDAKVDEVQALTAERSEKALVVMHNNGSFSSFGIESRYGFVFDVLGVKPASTEIAASLHGQPISSEFINQANPDILYIIDRTAVMEGKPVIDAEHLANPLLRQTKAWKNGKVIFVDADAWYITSASITSLKIVIDDIIKGYQS", "function": "Involved in the uptake of iron in complex with the siderophore anguibactin. Binds ferric-anguibactin in the periplasm and mediates its transport into the cytoplasm.", "AFDB_id": "AF-P11460-F1-model_v4" }, { "swissprot_id": "C0HKS6", "sequence": "MQPTMRIIVSMALLAYAVASAYHSNVKLRRDGKMVLYPFPRVGRASGNTWQLPLNDLYPEYEPAQVKRQLYAFPRVGRDPVMSRLGRSDLSRVESHEFQPMAVRRTESPGMWFGPRLGRAFKNDDDEITIQNESNDHSEPEQTELIHEDRRKRQTLN", "function": "Myoactive.", "AFDB_id": "AF-C0HKS6-F1-model_v4" }, { "swissprot_id": "P40452", "sequence": "MMLRLVTKGLPKVTPSAAKAVLVRGSLLHSFSTSARFNNSVAEDEAKIVLKDKNRPLRIDRELPDPTTERRKRIAGFLLFSVAIGSALSLIFNYEKTESPIISNTLYYIRRSPATKNILGESIEFDGIIPWVYGELNSVKGRINITFYIKGDKNVTGTVRLVADRNTHDEEFLIHEWSVTAAGQKIDLLAENTKTPI", "function": "Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors.", "AFDB_id": "AF-P40452-F1-model_v4" }, { "swissprot_id": "Q50LG0", "sequence": "MVVHSLGSTNLQENQSAVGAIAAWRLQHAGYSRVTTLCRSNYDAVKTSGFRLSTSLWGKHIYKPDRVANDIREVKHTEFDYVVDATKNISATWTLSISEIRQVVRPRTTILSLQNGMQPERRFTKAFPANTVLAGICFLSCSQISPGCILQTSHIRPHAFYIGMSSSPSFRDAKQKLRRLVSLDSSFLAVRDIRIQQWIKLITNVTFNSATALMNAHTRDVLDSASGIELVRALAEECYELGLALGMAIPQGTVDSIIEDFLSAPPVVTSMLQDLRAGRPLELDALLGKLKTYLVIL", "function": "Oxidoreductase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AF-toxins responsible for Alternaria black spot of strawberry disease by the strawberry pathotype (Ref.1). AF-toxin I and III are valine derivatives of 2,3-dyhydroxy-isovaleric acid and 2-hydroxy-isovaleric acid respectively, while AF II is an isoleucine derivative of 2-hydroxy-valeric acid. These derivatives are bound to a 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) moiety. On cellular level, AF-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment. The aldo-keto reductase AFTS1 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV) by reduction of its ketone to an alcohol. The acyl-CoA ligase AFT1, the hydrolase AFT2 and the enoyl-CoA hydratases AFT3 and AFT6, but also the polyketide synthase AFT9, the acyl-CoA dehydrogenase AFT10, the cytochrome P450 monooxygenase AFT11 and the oxidoreductase AFT12 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common EDA structural moiety. The exact function of each enzyme, and of additional enzymes identified within the AF-toxin clusters have still to be determined.", "AFDB_id": "AF-Q50LG0-F1-model_v4" }, { "swissprot_id": "P0ABC1", "sequence": "MSVSLVSRNVARKLLLVQLLVVIASGLLFSLKDPFWGVSAISGGLAVFLPNVLFMIFAWRHQAHTPAKGRVAWTFAFGEAFKVLAMLVLLVVALAVLKAVFLPLIVTWVLVLVVQILAPAVINNKG", "function": "A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.", "AFDB_id": "AF-P0ABC1-F1-model_v4" }, { "swissprot_id": "P36922", "sequence": "MAKKKTQQKTNAMRMVEQHKVPYKEYEFAWSEDHLSAESVAESLGIEKGRIFKTLVTVGNKTGPVVAVIPGNQELDLKKLAKASGNKKVEMLHLKDLEATTGYIRGGCSPIGMKKQFPTYLAEEAQQYSAIIVSAGKRGMQIELAPEAILSLTNGQFAEITTKE", "function": "Affects the expression of the receptor, named binding substance, that mediates mating aggregate formation. Could be a regulatory protein that suppresses the function or expression of ebsA and/or ebsMB.", "AFDB_id": "AF-P36922-F1-model_v4" }, { "swissprot_id": "P0AEQ0", "sequence": "MSILYEERLDGALPDVDRTSVLMALREHVPGLEILHTDEEIIPYECDGLSAYRTRPLLVVLPKQMEQVTAILAVCHRLRVPVVTRGAGTGLSGGALPLEKGVLLVMARFKEILDINPVGRRARVQPGVRNLAISQAVAPHNLYYAPDPSSQIACSIGGNVAENAGGVHCLKYGLTVHNLLKIEVQTLDGEALTLGSDALDSPGFDLLALFTGSEGMLGVTTEVTVKLLPKPPVARVLLASFDSVEKAGLAVGDIIANGIIPGGLEMMDNLSIRAAEDFIHAGYPVDAEAILLCELDGVESDVQEDCERVNDILLKAGATDVRLAQDEAERVRFWAGRKNAFPAVGRISPDYYCMDGTIPRRALPGVLEGIARLSQQYDLRVANVFHAGDGNMHPLILFDANEPGEFARAEELGGKILELCVEVGGSISGEHGIGREKINQMCAQFNSDEITTFHAVKAAFDPDGLLNPGKNIPTLHRCAEFGAMHVHHGHLPFPELERF", "function": "Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)-lactate) with a similar rate. Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown.", "AFDB_id": "AF-P0AEQ0-F1-model_v4" }, { "swissprot_id": "M1V9Q0", "sequence": "MTDPAVTPLAFSIPQLYCPFPTAIHPEVDTLTRAGMDFMTHHGFCNTEADRLVVANIDAGAIVARWYPNPDFPVDRLQMVTDFLYLYFLIDDLRFEVINSDTGLAGPIALFAQHLDLWEYPQAHRREELDLFHQAIHDLASRMAELTTPTKAARMRRSINGWFLALLREIALFNDDHAVMAEEYLPIRVVTVASRLMIDVNGFICPAEVPGDEWYSLKVQAAAEAAMSVCLYDNELYSAGKEQWLKSRATAHDRRPRNLVALIQAQTGGSTEHALQEVAEYRNRTVCLYLNLRSQLEKTASPALLAYLSVLDGVISGNLDAHATSSRYHNPDGHHPHAIAFTPLRTTDECSARAHTPIAPPIAWWWEQLDQ", "function": "Diterpene cyclases that can form multiple diterpene products.", "AFDB_id": "AF-M1V9Q0-F1-model_v4" }, { "swissprot_id": "Q5BGU9", "sequence": "MHLLSSLAALAAAITVAFADVQQCNAENASVRKEWGSLTPDEQLGYIDAVWCLRSLPSRLPNEQYPGVQDRVDDFVATHINLTMVIHRNAPFLPWHRQYIHLWETALREECGYNGTVPYWNWTKNPDLYTNPVFDTTQSPETSLSLSGDGAYVAPSPTDPDPDPGLDFAPGRGGGCVLDGPFKDWPVRMGPFSAAQAYPYAPVPENAFAHNPRCLQRNLDVARIQYYNNPSVLESLLAAPSIAVFQDILDRTIPGTWQQAIGAHGGGHISVGPTLADVFASPQDPVFMLHHGFIDLLWDAWQRSGSDTGEGTDRMRALNGTTMYTNPPGAEEATLDTVMEFGVLGSPKKIGEVMDIRGGEYCYRYE", "function": "Nonribosomal peptide synthetase; part of the pathway that mediates the biosynthesis of the gray-brown conidiophore pigment. The first step of the pathway is performed by the nonribosomal peptide synthetase ivoA that catalyzes ATP-dependent unidirectional stereoinversion of L-tryptophan to D-tryptophan with complete conversion. While the stereoinversion is catalyzed by the epimerization (E) domain of ivoA, the terminal condensation (C) domain stereoselectively hydrolyzes D-tryptophanyl-S-phosphopantetheine thioester and thus represents a non-canonical C domain function. D-tryptophan is acetylated, probably by an endogenous acetyltransferase (Probable). N-acetyltryptophan is further 6-hydroxylated into N-acetyl-6-hydroxytryptophan (AHT) by the cytochrome P450 monooxygenase ivoC. N-acetyl-6-hydroxytryptophan is substrate of the N-acetyl-6-hydroxytryptophan oxidase ivoB to produce the gray-brown conidiophore pigment.", "AFDB_id": "AF-Q5BGU9-F1-model_v4" }, { "swissprot_id": "Q8NEC5", "sequence": "MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN", "function": "Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.", "AFDB_id": "AF-Q8NEC5-F1-model_v4" }, { "swissprot_id": "P82886", "sequence": "GVQTSNASSPDFQLLVRASLQQLIPELASGVPSIGAEGVDPLRGLPPIVHNSNGFKVQLDDVSISGLSATLINDVNVDLTSNTIRIQATVPGYITATGIQTTDAEIMGIPLKGSGPFTISLANPSLAVTLTGAPSAGPNGQTYLRLTSASAAIEPGTPTADIKGFFPQFPPLEAAASAFASVVAPDVVQSLKPTLDKWLGGVALQRAQAVFSSVSYDALFPGRTPAAVGLYRAVPGLHTLPLPLSAFAYH", "function": "Has beta-carotene-binding activity. May be involved in the transport of carotenes from internal tissues to epidermis and cuticle of the locust.", "AFDB_id": "AF-P82886-F1-model_v4" }, { "swissprot_id": "Q6MR11", "sequence": "MLRIYADLTKFGIVVFSVLAGLAGYATGFQIENPFDWKIFLETLLGIYFLSSGSLALNQVQDWKIDQKMPRTAKRPIPSGKIKPAAAGILSVGLLLVGMNMLFKLEPVAGWVGLFCVFLYNGPYTLWWKRRWVFAAVPGAIPGALPVTIGYAVANPDIFNSESLYLFLIMFLWQMPHFWVLAIRYKDDYAAGGIPTLPVALGMEKTMFQVGLYTLVYVGVALAAPMFVHASWMFVLLTFPFVFKVLQEFYRYYKSNGTERWLAFFMWLNVSMLVFIIIPVIDKWNFLFIHHN", "function": "Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.", "AFDB_id": "AF-Q6MR11-F1-model_v4" }, { "swissprot_id": "Q9AVB0", "sequence": "MKRISNSIVGMLVVVLSVMLLLPVEGHEGHGVVELIMGKLGAPECGREASGKVCPDDLCCSVFGHCGVSVQHCGDGCQSQCVTNWRCGKDFDDRTCPKKLLCCSKDGWCGNTDAHCGEGCQSQCEQYNWRCGVDFGNRTCPNDLCCSVGGWCGTTDDHCGEGCQSQCEQYNWHCGVDFGNRTCPNDLCCSEWGWCGITEGYCGEGCQSQCNHQRCGKDFAGRTCLNDLCCSEWGWCGSSEAHCGQGCQSNCDYNRCGRNFGFRTCPNELCCSSGGWCGSNDAHCGKGCQSQCDYWRCGVDFSGRVCPQGRCCSAWGWCGDTEEYCEEGCQSQCKLSSLPSPLSQILAIRKLNATIPTMAVE", "function": "N-acetyl-D-glucosamine binding lectin. Has high hemagglutinating activity towards human erythrocytes. Shows potent mitogenic activity towards human peripheral blood lymphocytes.", "AFDB_id": "AF-Q9AVB0-F1-model_v4" }, { "swissprot_id": "Q6FTZ3", "sequence": "MSSSSIHTTEGSTPNTAGGMGKEPYSNVSGSQRSSDTLKQQKFIVSDAMAKNSRQLLFAHIYNYLVHNKFYSTASQFLKEVEVPLTTIENIGKIKENTVRDDSSQMRYDDIPENLLRPDMLLNASDTFLVEWWEIFRTLFDHVDGIPNESLDSNGNQEVFKQRIMAILPHNNPTVPPPFINGAENLVDPERHMNIARGSSVSQPSGVLRSPTQNELLNNSQDQRPPQFRSKSMMNGMPPGLSSMSTPNGVEGMQGNFERPTFQQSKSAALPTQRKSSIEEQANRNSSNFSGFGSQSPKNVNEDNEIDSKSAKGKLRSKSSKRGKVGKAAGTPKYNEVDEKHSTMQGSPFSPELLGSNNPVLQNQSKPSAQSQMNGSQWDPNFLMQQQRNPQQWQKLNGNNMQQDIPNSSHPSIGSNNPSNTSHRFNSRRKEQYDSKPEAIGNGSHRSSTSPSAGSVGNMSADYGDQNEYGSNKSSNFSGAFTNNNAMFQEMAKTMNLMMNQKSEEMNQWNKSNPYNMRPDNMPMSTMNWNNFPMPKGTSNSFNKDMLQAMQNKMMQSQSSSGMDPNLQQQYLMMMNMLMNFQSGNGFQSNPTNVYKSRGNDLDFAQPFSSENNLANDQSNIRSSYEAYQEDSKTPSTENGGRKMNMTPSLQSTNMISNGQMKHSTSRFSPTHGAPNQSELNKMESTQRGNDISHNYNPPNNRFVGNNLKSQNFSLASQDESVIAAAKKGRRKLTKLNKRNLATPESTSNTNYPESNKNGISTPNGSVGNKGKQTDINGHSNYPDNPFELFNI", "function": "Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.", "AFDB_id": "AF-Q6FTZ3-F1-model_v4" }, { "swissprot_id": "Q6IMP4", "sequence": "MHHLLEQSADMATALLAGEKLRELILPGSQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSVVPISYLCTYYATQKQNEFTCALGASPDGPVGSAGPTVRVSCKLPSVQLQRIIAGVDIVLLCFMNLIILVNLIHLFIFRKSNFIFDKLNKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDTTPTVRDSGIQTVDPSINPAEPDGSAEPPVVKRPRKKMKWIPTSNPLPQPFKEQLAIMRVENSKTEKPKPVRRKTATDTLIAPLLDAGARAAHHYKGSGGDSGPSSAPPAASEKKHTRHFSLDVHPYILGTKKAKTEAVPPALPASRSQEGGFLSQTEECGLGLAAAPTKDAPLPEKEIPYPTEPALPGLPSGGSFHVCSPPAAPAAASLSPGSLGKADPLTILSRNATHPLLHISTLYEAREEEEGGPCAPSDMGDLLSIPPPQQILIATFEEPRTVVSTVEF", "function": "Structural component of the gap junctions and the hemichannels.", "AFDB_id": "AF-Q6IMP4-F1-model_v4" }, { "swissprot_id": "C6Y4C8", "sequence": "MERKSQVSDTNNNSIPTNVLLKFVGFSVALFTLPLITYFWTLKTLFKGYQTLYAGLSAAVMVNIILALYIVAAFREDSGTPKKDIKRE", "function": "Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.", "AFDB_id": "AF-C6Y4C8-F1-model_v4" }, { "swissprot_id": "C5A3H2", "sequence": "MSEIETIGFHYVVEAAGCDPEILGNADRIREIFLEAAKVGNMEVKSSYFFKFSPTGVSGVVIVAESHISVHTWPEKGYAALDVYTCGTKAEPEKAVDYILEKFRAKYAHVSEIKRGIEEDDDTFTHMIMTWEESLRKNGNGKG", "function": "Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.", "AFDB_id": "AF-C5A3H2-F1-model_v4" }, { "swissprot_id": "Q4ZIN3", "sequence": "MSEHVEPAAPGPGPNGGGGGPAPARGPRTPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDMEDEEEEELTMEMFGNSSIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTSTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQVRIQEMLLQAPPLGPGTPTALPDDMNNNSGAPATAPDSAGQPPALGPVSPGASGSPGPVAAAPSSLVAAAASVAAAAGGDLGWMAETAAIITDASFLSGLSASLLERRPASPLGPAGGLPHAPQDSVPPSDSAASDTTPLGAAVGGPSPASMAPTEAPSEVGS", "function": "May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.", "AFDB_id": "AF-Q4ZIN3-F1-model_v4" }, { "swissprot_id": "B2V7Y8", "sequence": "MKKVFISGGGTGGHFYPALSVAENLKEKGFSITYIGTTNGIENKKDFPADEKILYPMRAVRGKSIVGKIQGVFSLLSTTFKVYKQIKKEKPDFSICFGGYTSIPLGLASFLARVPLYIHEQNSIPSYSNKILSYFAKKVFITFELTAKYFDRKKTVLTGMPLRKNIIERAKNYVYKPNQTKTVLVVGGSQGAKKLSESIISLASEMKDIKFILIKGKWQVEVPNLENLTVYEYVDNMEDLYTSADVVISRSGSSSVNEILCFGKYAIFVPFPYAASNHQYYNVKWLKDLGLCELIEEKDLSKEVLKKALEDAFNKDLESLSKKIKEYAIFDSDEKIVENILNDFKND", "function": "Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).", "AFDB_id": "AF-B2V7Y8-F1-model_v4" }, { "swissprot_id": "Q8L4Y5", "sequence": "MEALVVDAGSKFLKAGAAIPDQSPAMIIPSQMKRMVDDGSSSADNPTTVFEDVTLDPIERGLIRDWDAMEDLLRYVVYTGLGWEEGNEGNILFTDPLCTPKAIREQLVQLMFETFNVSGFYASEQAVLSLYAVGRISGCTVDIGHGKIDIAPVLEGAVQHIASKRFELGGTELTKLFAQELGKTNPSMNLSMSDVEKLKEQYANCAEDEIAYKKTQNCEIEQHTLPDGQVISIGRERYSVGEALFQPSILGLEEHGIVEQLVRIISTVSSENHRQLLENTVLCGGTTSMTGFESRFQKEANLCSSAIRPTLVKPPEYMPENLGMYSAWVGGAILAKVVFPQNQHVTKADYDETGPSVVHRKCF", "function": "Essential protein required during embryogenesis and all plant development stages, probably through a chromatin-mediated regulation of gene expression.", "AFDB_id": "AF-Q8L4Y5-F1-model_v4" }, { "swissprot_id": "Q58154", "sequence": "MVIYAQKDISNDFIKEIIKTGEILGEGHVSSFKACYQCGTCTGSCPSGRITAFRTRKLIRYAQFGMKSAIIDSEDLWMCTTCYECYERCPRTVKITDIIKVLRNIAAREGKMAEAHKKTALYVFKTGHAVPINDQIKKARKEIGLTEIPPTTHKYPDALEVVRGIMKDLRFCDMVGICTETMQLKPVEWKDMSE", "function": "Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).", "AFDB_id": "AF-Q58154-F1-model_v4" }, { "swissprot_id": "P50875", "sequence": "MSANSPTGNDPHVFGIPVNATPSNMGSPGSPVNVPPPMNPAVANVNHPVMRTNSNSNANEGTRTLTREQIQQLQQRQRLLLQQRLLEQQRKQQALQNYEAQFYQMLMTLNKRPKRLYNFVEDADSILKKYEQYLHSFEFHIYENNYKICAPANSRLQQQQKQPELTSDGLILTKNNETLKEFLEYVARGRIPDAIMEVLRDCNIQFYEGNLILQVYDHTNTVDVTPKENKPNLNSSSSPSNNNSTQDNSKIQQPSEPNSGVANTGANTANKKASFKRPRVYRTLLKPNDLTTYYDMMSYADNARFSDSIYQQFESEILTLTKRNLSLSVPLNPYEHRDMLEETAFSEPHWDSEKKSFIHEHRAESTREGTKGVVGHIEERDEFPQHSSNYEQLMLIMNERTTTITNSTFAVSLTKNAMEIASSSSNGVRGASSSTSNSASNTRNNSLANGNQVALAAAAAAAAVGSTMGNDNNQFSRLKFIEQWRINKEKRKQQALSANINPTPFNARISMTAPLTPQQQLLQRQQQALEQQQNGGAMKNANKRSGNNATSNNNNNNNNLDKPKVKRPRKNAKKSESGTPAPKKKRMTKKKQSASSTPSSTTMS", "function": "Transcription regulator. May recruit TATA binding protein (TBP) and possibly other basal factors to bind to the TATA box. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.", "AFDB_id": "AF-P50875-F1-model_v4" }, { "swissprot_id": "O43521", "sequence": "MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH", "function": "Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.", "AFDB_id": "AF-O43521-F1-model_v4" }, { "swissprot_id": "Q8U2H9", "sequence": "MDEGTRTVLRKFEHIEHCLKRNVEAHATNGFEDVHFVHMSLPEIDKDEIDLSVKFLGRKFDYPIMITGMTGGTRKGEVAWKINRTLAQAAEELNIPLGVGSQRAMIEKPETWESYYVRDVAPNVFLVGNLGAPQFGRNAKRKYGVKEVLYAIEKIDADAIAIHMNPLQESVQPEGDTTFSGVLEALAEITSSIDYPVIAKETGAGVSKEVAIKLESIGVSAIDISGVGGTSWSGVEYYRAKDELGKRLALRFWDWGIKTAISLAEVRFSTNLPIIASGGMRDGITMAKALAMGASLVGIALPVLKPAAKGDVEGVIKVIKGYVEEIKNAMFLVGARNVEELRKVPIVFTGFVREWLEQRIDLQEFVKKRAKLRFEFWNVGFYSYPYTSSSTHLF", "function": "Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).", "AFDB_id": "AF-Q8U2H9-F1-model_v4" }, { "swissprot_id": "P33406", "sequence": "MNMKKFVKKPLAIAVLMLASGGMVNMVHAEPTVINSKDISATKTVKEGGSFSVEFKATENEIVSGKLDADTPAFHLVMSDSGEHKGWNVRPTGASEGGQMVSADGTRVDLHTNELSWDNDHWWIDDGSERVEATFFLAAGDEVKAGEYQFTGRVEEYVE", "function": "Major pilus subunit. Expressed only in pathogenic serotypes, it is part of myf, a probable virulence factor.", "AFDB_id": "AF-P33406-F1-model_v4" }, { "swissprot_id": "Q2UP89", "sequence": "MLVMQLLLPFLASTAAAAAAIDSTSSSNGSDHHGSSFQAECESFKAKINVTNANVHSVTYVPAGVNISMADNPSICGGDEDPITSTFAFCRIALNVTTSSKSQIFMEAWLPSNYSGRFLSTGNGGLGGCVKYDDMAYAAGYGFATVGTNNGHFGNNGVSFYQNTEVVEDFAYRALHTGVVVGKELTKNFYPQGYNKSYYLGCSTGGRQGWKSVQTFPDDFDGVVAGAPAFNFINLTSWGARFLTLTGDSSAETFVTETQWTAVHNEIIRQCDSLDGAKDGIIEDPDLCQPIIEALLCNATQSSTSGTCLTGAQVKTVNGVFSATYGLNGSFLYPRMQPGSELAAYSSYYSGTPFAYAEDWYRYVVFNNTNWDVATWTVQDAAIANAQDPYQISTWNGDLSPFQKKGGKVLHYHGMEDAIISSESSKVYYKHVADTMNLSPSELDSFYRFFPISGMAHCANADGPSAIGQGTGTFAGNNPQDNVLLAMVQWVEEGVAPDFVRGAKLNGSTVEYRRKHCKYPKRNRYVGPGSYTDENAWECV", "function": "Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.", "AFDB_id": "AF-Q2UP89-F1-model_v4" }, { "swissprot_id": "Q9Y6Q2", "sequence": "MCSTNPGKWVTFDDDPAVQSSQKSKNFPLENQGVCRPNGLKLNLPGLREFPSGSSSTSSTPLSSPIVDFYFSPGPPSNSPLSTPTKDFPGFPGIPKAGTHVLYPIPESSSDSPLAISGGESSLLPTRPTCLSHALLPSDHSCTHPTPKVGLPDEVNPQQAESLGFQSDDLPQFQYFREDCAFSSPFWKDEGSDSHFTLDPPGSKKMFSSRNKEMPIDQKSLNKCSLNYICEKLEHLQSAENQDSLRSLSMHCLCAEENASSFVPHTLFRSQPKSGWSFMLRIPEKKNMMSSRQWGPIFLKVLPGGILQMYYEQGLEKPFKEIQLDPYCRLSEPKVENFSVAGKIHTVKIEHVSYTEKRKYHSKTEVVHEPDIEQMLKLGSTSYHDFLDFLTTVEEELMKLPAVSKPKKNYEEQEISLEIVDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLNDLELPKRDESYYEKDSEKKGIDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLYNGDNLPFSLKSVVVVQGAYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTMNLQRQKSLKAKMNRRACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSLDHPHCLSYKLELGSDQEIPSDWYPFATVQFSVPDTCASRTEVRSLGVESDVQPQKHVQQRACYNIQVEIEKKWIKIDGEDPDKIGDCITQ", "function": "May be involved in the endocytic machinery.", "AFDB_id": "AF-Q9Y6Q2-F1-model_v4" }, { "swissprot_id": "P55708", "sequence": "MLHTTVTQLIGQTPVMSIDVPGRNATLVLKIEKNNPGGSMKDRMARSMVIAALQDGRLPPGGTIVESSSGNTGTGLALAALEFGLRFIAVVDHHAAPDKIRMMRALGAEIRYVEGDFREDEVAVVERQRLAAQLGAQLPGALFMNQSDNPANPEGYTGLVDELVAQLPDGIDAFVGCVGTGGSMTGISQRLKRNNPAVRTIAVEPAGSIVFGKPGHPYYQSGTGTPAGDEVGKVLDYGCIDEGVQVTDTQAFETARYIARRKGLLVGGSTGGAIYKALEFIGAGKLTGTVVTTVADGGEKYLGTIFDEEWMAKRRLLDPAIAAQLDGWLFGKARAA", "function": "As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction.", "AFDB_id": "AF-P55708-F1-model_v4" }, { "swissprot_id": "Q8X826", "sequence": "MDEFKPEDELKPDPSDRRTGRSRQSSERSERTERGEPQINFDDIELDDTDDRRPTRAQKERNEEPEIEEEIDESEDETVDEERVERRPRKRKKAASKPASRQYMMMGVGILVLLLLIIGIGSALKAPSTTSSDQTASGEKSIDLAGNATDQANGVQPAPGTTSAENTQQDVSLPPISSTPTQGQTPAATDGQQRVEVQGDLNNALTQPQNQQQLNNVAVNSTLPTEPATVAPVRNGNASRDTAKTQTAERPATTRPARQQAVIEPKKPQATVKTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPAAGGKTAGNVGSLKSAPSSHYTLQLSSSSNYDNLNGWAKKENLKNYVVYETTRNGQPWYVLVSGVYASKEEAKKAVSTLPADVQAKNPWAKPLRQVQADLK", "function": "Non-essential cell division protein.", "AFDB_id": "AF-Q8X826-F1-model_v4" }, { "swissprot_id": "Q8BVA5", "sequence": "MASEVEEQIPVREEFFLCGGVETKIIKCGPWTNLFEKQDVSKPKQLIFIIPGNPGYSAFYVPFAKALYTLMKSRFPVWIISHAGFSVTPKDKKVLAAPQEESNAQKIEDVYGLNGQIEHKIAFLRAHVPKDVKLILIGHSVGTYMTLHVMKRVLELPVAHAFLLFPTIERMSESPNGKFATPFLCQFRYLLYATSYLLFKPCPEVIKSFIIQKLMGQMNIKLELPLTDILQPFCLANAAYLGSQEMVQIVKRDDDIIKEFLPKLKFYYGKTDGWCPVKYYEDMKKDFPEGNIYLCEKGIPHAFVLDFSQEMATIVAEWINNRPPRK", "function": "Probable serine lipid hydrolase associated with lipid droplets. Appears to lack cholesterol esterase activity. Appears to lack triglyceride lipase activity. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.", "AFDB_id": "AF-Q8BVA5-F1-model_v4" }, { "swissprot_id": "B8BI93", "sequence": "MEQHEEAAERKPSPPVIFRLFGVEVRGGGGGVDEEEYEEEEVEGGLFIKKSSSMPNLTSIDPLPVPADGGKRRASDDSELASGQQKRRRRKVQERKKGVPWTEEEHKKFLEGLRQLGKGDWRGISKNFVTSRTATQVASHAQKYFLRQTNPGKKKRRASLFDVVAECSDDQLPSPQSVGTKPPTQDIIHTDRGDVPILSYPVARGFRGDSVQVDELTEYVKRLKAAEDMSLSMISGLEMASSSISSLELSIAPPHCAIEAAIKVL", "function": "Transcription activator that binds to 5'-TATCCA-3' elements in gene promoters. Derepress weakly the sugar-repressed transcription of promoters containing SRS. Contributes to the sugar-repressed transcription of promoters containing 5'-TATCCA-3' elements.", "AFDB_id": "AF-B8BI93-F1-model_v4" }, { "swissprot_id": "Q0K846", "sequence": "MSNHSNAAAVRAFRILEILSAADGPLSLAAIVQAIELPKQTVHRILKQLESTWLVSRTAGNRHYECSSRVRQLAVNVLMQAGPAAARHAILQQLVDKIGETCNLTMLSGDDVVYLDRVETQWPLRMHLQPGSRVPLHCTASGKLLLAFLPSAQRQRLVASLPLRAHSAHTITNAEALHAELAETRQRRLGVNNQENLEGMIAVAVPVMRNRSRACAAIAVQVPMARMTMDQLMGFVPDLRLAADEMVKTFCE", "function": "May regulate transcription of the sauSTU operon.", "AFDB_id": "AF-Q0K846-F1-model_v4" }, { "swissprot_id": "P42238", "sequence": "MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSPFFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFGDQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGYLFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKGGVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDENGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVRVAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPFEISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKRPCLVR", "function": "Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc).", "AFDB_id": "AF-P42238-F1-model_v4" }, { "swissprot_id": "Q9UNA4", "sequence": "MEKLGVEPEEEGGGDDDEEDAEAWAMELADVGAAASSQGVHDQVLPTPNASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHMEDFPKDKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFKQLPVDIQEEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQVSSVSPCEPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFPNLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVDEKITFPSDIDPQVFYELPEAVQKELLAEWKRAGSDFHIGHK", "function": "Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.", "AFDB_id": "AF-Q9UNA4-F1-model_v4" }, { "swissprot_id": "P53178", "sequence": "MGIIEEKALFVTCGATVPFPKLVSCVLSDEFCQELIQYGFVRLIIQFGRNYSSEFEHLVQERGGQRESQKIPIDQFGCGDTARQYVLMNGKLKVIGFDFSTKMQSIIRDYSDLVISHAGTGSILDSLRLNKPLIVCVNDSLMDNHQQQIADKFVELGYVWSCAPTETGLIAGLRASQTEKLKPFPVSHNPSFERLLVETIYS", "function": "Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.", "AFDB_id": "AF-P53178-F1-model_v4" }, { "swissprot_id": "A8WTV9", "sequence": "MSHAPGEGRPVSSLFPARCNEEVASQNATTMATLNEIELSEIEELSLNFKETPRQDHSMTPVELCYFDDFATTLVVDAVLNFSTHKMCKKRRYLYGDEQRVARELMERFRKDQDWTPAIYGFLNMRSVRSFIEKLAFNKQLEFRDHIIRFLNVFHHDSGYTIQECTRYSLEGNQGAKLVATRAWYRGDKIQRLSGVVCLLSTQDEDTILQPEGSDFSVMYSNRKRCSTLWLGPGAYINHDCRPTCEFVSHGSTAHIRVLRDMVAGDEITCFYGSEFFGPKNMDCECLTCEKTKRGKFSTSDEEENDEPSALSEKRIKYGLRSRSRV", "function": "Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.", "AFDB_id": "AF-A8WTV9-F1-model_v4" }, { "swissprot_id": "Q8NG08", "sequence": "MARSSPYLRQLQGPLLPPRDLVEEDDDYLNDDVEEDEESVFIDAEELCSGGVKAGSLPGCLRVSICDENTQETCKVFGRFPITGAWWRVKVQVKPVVGSRSYQYQVQGFPSYFLQSDMSPPNQKHICALFLKECEVSSDDVNKFLTWVKEVSNYKNLNFENLRETLRTFHKETGRKDQKQPTQNGQEELFLDNEMSLPLENTIPFRNVMTALQFPKIMEFLPVLLPRHFKWIIGSGSKEMLKEIEEILGTHPWKLGFSKITYREWKLLRCEASWIAFCQCESLLQLMTDLEKNALIMYSRLKQICREDGHTYVEVNDLTLTLSNHMSFHAASESLKFLKDIGVVTYEKSCVFPYDLYHAERAIAFSICDLMKKPPWHLCVDVEKVLASIHTTKPENSSDDALNESKPDEVRLENPVDVVDTQDNGDHIWTNGENEINAEISEVQLDQDQVEVPLDRDQVAALEMICSNPVTVISGKGGCGKTTIVSRLFKHIEQLEEREVKKACEDFEQDQNASEEWITFTEQSQLEADKAIEVLLTAPTGKAAGLLRQKTGLHAYTLCQVNYSFYSWTQTMMTTNKPWKFSSVRVLVVDEGSLVSVGIFKSVLNLLCEHSKLSKLIILGDIRQLPSIEPGNLLKDLFETLKSRNCAIELKTNHRAESQLIVDNATRISRRQFPKFDAELNISDNPTLPISIQDKTFIFVRLPEEDASSQSSKTNHHSCLYSAVKTLLQENNLQNAKTSQFIAFRRQDCDLINDCCCKHYTGHLTKDHQSRLVFGIGDKICCTRNAYLSDLLPENISGSQQNNDLDASSEDFSGTLPDFAKNKRDFESNVRLCNGEIFFITNDVTDVTFGKRRSLTINNMAGLEVTVDFKKLMKYCRIKHAWARTIHTFQGSEEQTVVYVVGKAGRQHWQHVYTAVTRGRCRVYVIAEESQLRNAIMKNSFPRKTRLKHFLQSKLSSSGAPPADFPSPRKSSGDSGGPSTPSASPLPVVTDHAMTNDVTWSEASSPDERTLTFAERWQLSSPDGVDTDDDLPKSRASKRTCGVNDDESPSKIFMVGESPQVSSRLQNLRLNNLIPRQLFKPTDNQET", "function": "5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.", "AFDB_id": "AF-Q8NG08-F1-model_v4" }, { "swissprot_id": "Q12440", "sequence": "MSFQITPTRDLKVITDELQTLSSYIFHTNIVDDLNSLLTWMSPNDAKSNHQLRPPSLRIKNIIKVLFPNNATTSPYSMINTSQANNSIVNEGNTNKELQLQLFSTLKEFYIFQVRYHFFLHFNNINYLKDIQRWENYYEFPLRYVPIFDVNVNDWALELNSLRHYLLNRNIKFKNNLRTRLDKLIMDDDFDLADNLIQWLKSANGSLSSTELIVNALYSKINKFCEDNMSRVWNKRFMIMETFNKFINQYWSQFSKLVGCPEDDHELTTTVFNCFESNFLRIRTNEIFDICVLAYPDSKVTLLELRKIMKDFKDYTNIVTTFLSDFKKYILNPSVTTVDALLRYVKTIKAFLVLDPTGRCLHSITTFVKPYFQERKHLVNVLLYAMLDLPEEELKEKINFNVDMKALLSLVDTLHDSDINQDTNITKRDKNKKSPFLWNLKVKGKRELNKDLPIRHAMLYEHILNYYIAWVPEPNDMIPGNIKSSYIKTNLFEVLLDLFESREFFISEFRNLLTDRLFTLKFYTLDEKWTRCLKLIREKIVKFTETSHSNYITNGILGLLETTAPAADADQSNLNSIDVMLWDIKCSEELCRKMHEVAGLDPIIFPKFISLLYWKYNCDTQGSNDLAFHLPIDLERELQKYSDIYSQLKPGRKLQLCKDKGKVEIQLAFKDGRKLVLDVSLEQCSVINQFDSPNDEPICLSLEQLSESLNIAPPRLTHLLDFWIQKGVLLKENGTYSVIEHSEMDFDQAQKTAPMEIENSNYELHNDSEIERKYELTLQRSLPFIEGMLTNLGAMKLHKIHSFLKITVPKDWGYNRITLQQLEGYLNTLADEGRLKYIANGSYEIVKNGHKNS", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.", "AFDB_id": "AF-Q12440-F1-model_v4" }, { "swissprot_id": "Q8IZ52", "sequence": "MRASLLLSVLRPAGPVAVGISLGFTLSLLSVTWVEEPCGPGPPQPGDSELPPRGNTNAARRPNSVQPGAEREKPGAGEGAGENWEPRVLPYHPAQPGQAAKKAVRTRYISTELGIRQRLLVAVLTSQTTLPTLGVAVNRTLGHRLERVVFLTGARGRRAPPGMAVVTLGEERPIGHLHLALRHLLEQHGDDFDWFFLVPDTTYTEAHGLARLTGHLSLASAAHLYLGRPQDFIGGEPTPGRYCHGGFGVLLSRMLLQQLRPHLEGCRNDIVSARPDEWLGRCILDATGVGCTGDHEGVHYSHLELSPGEPVQEGDPHFRSALTAHPVRDPVHMYQLHKAFARAELERTYQEIQELQWEIQNTSHLAVDGDQAAAWPVGIPAPSRPASRFEVLRWDYFTEQHAFSCADGSPRCPLRGADRADVADVLGTALEELNRRYHPALRLQKQQLVNGYRRFDPARGMEYTLDLQLEALTPQGGRRPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLAPGFLEAFATAALEPGDAAAALTLLLLYEPRQAQRVAHADVFAPVKAHVAELERRFPGARVPWLSVQTAAPSPLRLMDLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVAPPQGPGPPELGRDTGRFDRQAASEACFYNSDYVAARGRLAAASEQEEELLESLDVYELFLHFSSLHVLRAVEPALLQRYRAQTCSARLSEDLYHRCLQSVLEGLGSRTQLAMLLFEQEQGNST", "function": "May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress.", "AFDB_id": "AF-Q8IZ52-F1-model_v4" }, { "swissprot_id": "A1TM37", "sequence": "MQAAIKGRNVVVVGTQWGDEGKGKLVDWLTESAQGVVRFQGGHNAGHTLVINGVKTALHLIPSGIMRPGVKCYIGNGVVLSAAKLFEEIEGLEKAGVEVRSRLRISEACPLILPFHAALDVAREAAREHGGSEKIGTTGRGIGPAYEDKVARRALRVQDLKHPERFAAKLKELLALHNHVLKSFLHSGSFQFGSALQPYLKDGEVQFDAVYQEAMRHAELLKPMIADVSRELNEAHKAGANLLFEGAQGTLLDVDHGTYPYVTSSNCVAGNAAAGSGVGPGLLHYVLGITKAYCTRVGGGPFPTELEWEKPGTPGYHMSTIGAEKGVTTGRSRRCGWFDAALLKRSAQVNGLTGLCITKLDVLDGLEELKLCVGYELDGERIDILPMGAEEIARCVPVYETLAGWSDSTVGVTQYDSLPANARRYLERIAEVTAVPIAMISTSPDRDHTIMMQHPYAAQ", "function": "Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.", "AFDB_id": "AF-A1TM37-F1-model_v4" }, { "swissprot_id": "O07594", "sequence": "MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFNLTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVALLCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYDVNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITFRSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSLRTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEILGAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA", "function": "May play a role in resistance to osmotic downshock.", "AFDB_id": "AF-O07594-F1-model_v4" }, { "swissprot_id": "C0HKR1", "sequence": "MCRIFIVLLVVAALAIIIEGQLTFSSGWGNGKRSISSEQINDDCNPEEAIFQIYKLIVSEGERIRACQRDGKM", "function": "This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.", "AFDB_id": "AF-C0HKR1-F1-model_v4" }, { "swissprot_id": "Q6ZDE3", "sequence": "MAFLLFFVFVTAAVLCFVVPAFLLLCTSVQRRRDVGQGGGRDWQKKKKLRLPPGSMGWPYVGETLQLYSQDPNVFFASKQKRYGEIFKTNLLGCPCVMLASPEAARFVLVSQARLFKPTYPPSKERMIGPSALFFHQGEYHLRLRRLVQAALAPDSLRALVPDVDAAVAATLAAWSGGHVASTFHAMKKLSFDVGVVTIFGGRLGRRHREELRTNYSVVERGYNCFPNRFPGTLYHKAIQARKRLRAILSEIVAERRARGGGGGGGGDDLLGGLMRSRDDGTAGAVALLTDDQIADNVVGVLFAAQDTTASVLTWILKYLHDSPKLLEAVKAEQMAIYVANEGGKRPLTWTQTRSMTLTHQVILESLRMASIISFTFREAVADVEYKGFLIPKGWKVMPLFRNIHHNPDYFQDPQKFDPSRFKVAPRPSTFLPFGSGVHACPGNELAKLEMLVLVHRLVTAYRWEIVGASDEVEYSPFPVPRGGLNAKLWKQEAEEDMYMAMGTITAAGA", "function": "Involved in the oxidative degradation of abscisic acid.", "AFDB_id": "AF-Q6ZDE3-F1-model_v4" }, { "swissprot_id": "P01189", "sequence": "MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE", "function": "Endogenous opiate.", "AFDB_id": "AF-P01189-F1-model_v4" }, { "swissprot_id": "P15362", "sequence": "MIKENLFFEWVDKNNKKLKLKWKILILLLSLLLFIFSFYSLFQPINYGSTRIFTKNLKELFTFSNYSKKYPSWTLWQLSWYYMFLTIRYCALGTTLGFIFAFFTSFVSSNFQKYKFIRYIINIIIIFFKAFPISLFVYFFSIGFDKELAATLILFWFSWLWMHKYFLDFLNNLDKTNYKIMHMKTNENFASFRKTLFPYIVNKYFMFFVYSLESNIRWTTIINAAGVIGIGLLLNDARDFSLGWSVVGIPLLVILVTIIFFEFLTLFLNKVILNIKNINYQNTSFLWIKLNFRRIFKWFFVLFFVGLNIYSIIKISSFTLYPNYIKNFWNHFFSFQNEVFSHNKENNPFYWILILIYQCIVSITIIAIISLVFSILGNEKLNNVTQWIPLRFLNTLFRIIPTIIFIYLFSIFWIGTNIFLLVAVITALRKSTSLVKQLNESINSINWEIYKTLEIQGKSKFQRIIKFVFPSIKKDYLSFLLFYFENQVQTLILLGSVGGSLLGSKISIVGQAGERTENILELMTYSWISWVFIAIIQLLQFYFNLIVQNKKISQLYLIKNLNTYFTKIKVIFKNKFSSDQ", "function": "Probably part of a high-affinity transport system.", "AFDB_id": "AF-P15362-F1-model_v4" }, { "swissprot_id": "A2C0K7", "sequence": "MDKKLHSVSPESGPNSNLDLTPQLAQSSSAFLFEPKNIVPFETALGWQKNFLKNLIEEPFSPQAVWLLEHFSCFTMGRGSDKKNLLFEENNSPLPVFSIERGGEVTHHMPGQIVGYLVLNLSLHKKDLAWYLRELEQVLIDVLDLLGIEGKRVDGLTGVWCEDKKVGSIGIGCKRWVTQHGFSLNVDCDLIGFEKIIPCGLDKVKVGKLSDWIPGIKVCDVTPLLRESVKRRFKLNWEKINQSL", "function": "Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.", "AFDB_id": "AF-A2C0K7-F1-model_v4" }, { "swissprot_id": "P0DKP3", "sequence": "LHDPCDNTEDCEDGLECNRNKCLIPYDSDKTCETGWDCVHGVWCSSFPGGSPGCRMDYRCKNEQCEDPATECVDEICGRKEGERCIGPCKAGLTCRNGYCRKPW", "function": "Acts as a neurotoxin by inhibiting an ion channel.", "AFDB_id": "AF-P0DKP3-F1-model_v4" }, { "swissprot_id": "Q8RGF2", "sequence": "MNFEKIQYIERKTGEIKTEKVMGEGALKFLYYNPFGKLALHAVVKRKFLSDWYGRKMSKPESKEKIKSFVEEMEIDMSEYKRPIEDYASFNDFFYRELKDGARKIDYNENVIVSPADGKILAYQNIKEVDKFFVKGSKFTLEEFFNDKELAKKYEDGTFVIVRLAPADYHRFHFPVDGEISEIKKILGYYYSVSTHAIKTNFRIFCENKREYAILKTEKFGDIAMFDIGATMVGGIVQTYKTNSSVKKGEEKGYFLFGGSTCILVFEKNKVVIDKDIIENTQNKIETRIYMGEKFGNEKN", "function": "Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).", "AFDB_id": "AF-Q8RGF2-F1-model_v4" }, { "swissprot_id": "Q6MRJ2", "sequence": "MKKKNGRDSKELADFALGESQTNYPETYAPEVLEAFDNKNPGKIAWTTFVCTEFTSLCPKTRQPDFAKIFINYIADKKMVESKSLKLYLFSFRNHGDFHEDCVQTICDDLVKLMKPKYIEVIGEFTPRGGIAIYPYANYAAKDKFFQELYKKRMSEYAPGKYSMELSKLY", "function": "Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).", "AFDB_id": "AF-Q6MRJ2-F1-model_v4" }, { "swissprot_id": "Q8G5C3", "sequence": "MDSQSPSAGARPITHTTTPPARKLPDIHLDIVLVVFCGGAIGTAIRYAFAQIPAAGSFHTGTFVANMLACFCYAGLTAYLAGASRFGARSKELASRGLGMGVCGGLSTMSTLALEGFTAIRDGQVAAGIAYLLVTFALGLVCASAGVWAGTHLAGSSNVSAEASADTNAATTSKGGKA", "function": "Important for reducing fluoride concentration in the cell, thus reducing its toxicity.", "AFDB_id": "AF-Q8G5C3-F1-model_v4" }, { "swissprot_id": "Q8LIY8", "sequence": "MSPAMLQASSLCVSAALSGAASRPGRLASQGHQGKRAVAQPLAASAVTEAAPPAPVVAPPARPVDAPRRRGGRGGGGGGGELVAWKSVRQERWEGALEVDGELPLWLDGTYLRNGPGLWNLGDYGFRHLFDGYATLVRVSFRGGRAVGAHRQIESEAYKAARAHGKVCYREFSEVPKPDNFLSYVGQLATLFSGSSLTDNSNTGVVMLGDGRVLCLTETIKGSIQVDPDTLDTVGKFQYTDKLGGLIHSAHPIVTDTEFWTLIPDLIRPGYVVARMDAGSNERQFVGRVDCRGGPAPGWVHSFPVTEHYVVVPEMPLRYCAKNLLRAEPTPLYKFEWHLESGSYMHVMCKASGKIVASVEVPPFVTFHFINAYEETDEEGRVTAIIADCCEHNANTAILDKLRLHNLRSSSGQDVLPDARVGRFRIPLDGSQFGELETALDPEEHGRGMDMCSINPAHVGREYRYAYACGARRPCNFPNTLTKVDLVERTAKNWHEEGSVPSEPFFVPRPGATEEDDGVAISMVSAKDGSGYALVLDGKTFEEVARAKFPYGLPYGLHCCWVPRKRNSK", "function": "Involved in strigolactones biosynthesis by cleaving the C(27) 9-cis-10'-apo-beta-carotenal produced by CCD7. Produces the C(19) carlactone and a C(8) hydroxyaldehyde. Also shows lower activity with all-trans-10'-apo-beta-carotenal producing a C(9) dialdehyde and the C(18) 13-apo-beta-carotenone. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.", "AFDB_id": "AF-Q8LIY8-F1-model_v4" }, { "swissprot_id": "P68569", "sequence": "MKKWIVLFLVLIAAAISIFVYVSTGSEKPFYNDINLTQYQKEVDSKKPKFIYVYETSCPPCQEIKPELNEVIKKEKLKVQALNIEEKENYNTEFLDKYNLNKTPTILYYKDGKEKDRLEGYRSASQIEKFFDKNGDR", "function": "Unknown; dispensable for production of the lantibiotic sublancin 168 and for competence for DNA uptake.", "AFDB_id": "AF-P68569-F1-model_v4" }, { "swissprot_id": "Q1QUN2", "sequence": "MQTNKRLKMASCVKAAAMLGMLLSVSISTTAQADSWRGWNIHPPSYPNGKALESFAKEVAEKTEGRVEPKVYHNAVLGDQPDAIEQTRSGALDFANFNMGPMGPIVPAANVLSLPFIFKSPDDMYRIMDGEIGERFADALAEKNLIVLSWFGSGARSLYNTDHPVETPDDVEGLKVRVMNNDLYVQMIDEMGGNATPMAYGEVYQSLKTGVIDGAENNYPSYESSGHYEVANYYSLTEHLILPECLCVAKASWEELSEKDRQAIREAAEDAAKEQRALWEEGVQASKQKILDAGVKINEVDDKSAFQAKMQPIYDQFVQEHPELESLVTDIQDAQS", "function": "Solute-binding protein that binds D-glucuronate (in vitro). Probably part of a tripartite ATP-independent periplasmic (TRAP) transport system that mediates solute transport into the cytoplasm.", "AFDB_id": "AF-Q1QUN2-F1-model_v4" }, { "swissprot_id": "Q12069", "sequence": "MQRNNRLRNLFTVPVIMARQLKRNALSAGLAFAGNATSNEFDEHLQNEVEREREIQKKKKIKRTQSKKSPDLINKSTFQSRTIGSKKEKHRQLDPEYEIVIDGPLRKIKPYHFTYRTFCKERWRDKKLVDVFISEFRDRESEYYKRTIENGDVHINDETADLSTVIRNGDLITHQVHRHEPPVTSRPIKVIFEDDNIMVIDKPSGIPVHPTGRYRFNTITKMLQNNLGFVVNPCNRLDRLTSGLMFLAKTPKGADNIGDQLKAREVTKEYVAKVVGEFPETEVIVEKPLKLIEPRLALNAVCQMDEKGAKHAKTVFNRISYDGKTSIVKCKPLTGRSHQIRVHLQYLGHPIANDPIYSNDEVWGNNLGKGGQADFDIVITKLDEIGKRKPAKSWFHSNGGYGEVLRQEKCSICESDLYTDPGPNDLDLWLHAYLYESTETEEGTEKKKWCYKTEYPEWALRR", "function": "Responsible for synthesis of pseudouridine from uracil-32 in mitochondrial transfer RNAs.", "AFDB_id": "AF-Q12069-F1-model_v4" }, { "swissprot_id": "Q10056", "sequence": "MLLSVRGVPVEIPSLKDTKKSKGIIRSGWVMLKEDKMKYLPWTKKWLVLSSNSLSIYKGSKSESAQVTLLLKDIQKVERSKSRTFCFKLRFKSSTKNFEIQACELSVADNMECYEWMDLISSRALASKVSSPMNPKHQVHVGIDNEGNYVGLPKEWILLLQSSSITKQECMEEPKAVIQALDFYSKQLDTTSETKDSFSFCKETLPRSSTTSYSIRDADKHHKLTTSGVTKMNITERCKPKTTIQTDKKHIIRPFIEDKSHVESIMTGKVTKVPVKADSKNTLSRRMTDRQALAMLKDSVTSHDPVEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNEITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSKLTEAQIARICLETCKGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTIDTIFRATAAELLTHSFLNQACPTEDLKSIIFSRKANTHIN", "function": "Forms an activated complex with GTP-bound Ras-like cdc42. Participates in Ras-dependent morphological control and mating response pathways.", "AFDB_id": "AF-Q10056-F1-model_v4" }, { "swissprot_id": "Q6NZL8", "sequence": "MGAAAVRWHLYLLLALGARGRLVGGSGLPGAVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGRQCEDIDECENDYYNGGCVHDCINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPMCGCHQKYALHADGRTCIEKDEAAIERSQFNATSVADVDKRVKRRLLMETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLMNNGGCDHFCRNTVGSFECGCQKGHKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCRRGYTLYGTTHCGDVDECSMNNGSCEQGCVNTKGSYECVCPPGRRLHWNQKDCVEMNGCLSRSKASAQAQLSCGKVGGVENCFLSCLGHSLFMPDSESSYILSCGVPGLQGKTLPKRNGTSSSTGPGCSDAPTTPIRQKARFKIRDAKCHLQPRSQERAKDTLRHPLLDNCHVTFVTLKCDSSKKRRRGRKSPSKEVSHITAEFEVEMKVDEASGTCEADCMRKRAEQSLQAAIKILRKSIGRNQFYVQVLGTEYEVAQRPAKALEGTGTCGIGQILQDGKCVPCAPGTYFSGDPGQCMPCVSGTYQDMEGQLSCTPCPSSEGLGLAGARNVSECGGQCSPGYFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHTGTASFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCISCPGNTSTDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECGDVLVMRKSASPTSVTTYETCQTYERPIAFTSRSRKLWIQFKSNEANSGKGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESKEMFPRSFIKLLRSKVSRFLRPYK", "function": "Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.", "AFDB_id": "AF-Q6NZL8-F1-model_v4" }, { "swissprot_id": "P00714", "sequence": "MMRFVPLFLACISLPAFQATEFTKCEVSHAIEDMDGYQGISLLEWTCVLFHTSGYDSQAIVKNNGSTEYGLFQISNRNWCKSSEFPESENICDISCDKFLDDELADDIVCAKKIVAIKGIDYWKAHKPMCSEKLEQWRCEKPGAPALVVPALNSETPVP", "function": "Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.", "AFDB_id": "AF-P00714-F1-model_v4" }, { "swissprot_id": "P36070", "sequence": "MMAFENTSKRPPQDFVAPIDQKKRKVQFSDSTGLVTLQPEEIKDEVFSAAMYSRFVKSALDDLDKNDSTQIGIIANQVALPSKNPERINDKNLNILLDILSSNINRIESSRGTFLIQSIINFEKWWELPPHTLSKYIYFIKILCSSIPKWWQDVSMILVSCFILPIKQTVCHHDMLKYFLRMIPSSMGFIDTYLAKFFPNKNDTRRKLVNYTSNLLKLRGYCSELGFQIWSLLIEKIISIDVELQNELDELDDDVDDDDLEEVDLEDDDDLDDDSGDDDDENCGNSNEELRSGAADGSQSDSEDMDIIEGMDGTEEYNVELTQGIKELSTKLDSILTLVSTHVEEQVTPESLESGEGVGVFNTLTTLFKTHVLPTYYTRSIQYIMFHVSQQQLELMDSFLVTLIDISFAVNEAAEKKIKSLQYLGSYIARAKKLSRTQIIFVASYLTSWLNRYVIEREEEVDQRGGMERFKHFYAAFQALCYIFCFRHNIFRDTDGNWECELDKFFQRMVISKFNPLKFCNENVMLMFARIAQQESVAYCFSIIENNNNERLRGIIGKADSDKKENSAQANTTSSSWSLATRQQFIDLQSYFPYDPLFLKNYKILMKEYYIEWSEASGEYESDGSDD", "function": "Required for efficient transcription initiation by RNA polymerase I. Interacts with Pol I in the absence of template DNA and stimulates recruitment of Pol I, but does not remain as part of stable preinitiation complex.", "AFDB_id": "AF-P36070-F1-model_v4" }, { "swissprot_id": "O60518", "sequence": "MAATASAGVPATVSEKQEFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDEDGTNHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDIIKRLLDQCIQDQEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMVDLQDDEDWVNADEMEEDDFDSNAVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSLLVLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLKTQSDLNNMEDDDPQTSYMVSAWARMCKILGKDFQQYLPLVIEPLIKTASAKPDVALLDTQDVENMSDDDGWQFVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKLMVPLLKFYFHDNVRVAAAESMPFLLECARIRGPEYLAQMWQFICDPLIKAIGTEPDTDVLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSDILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAIGKILKFKPNCVNVDEVLPHWLSWLPLHEDKEEAIQTLSFLCDLIESNHPVVIGPNNSNLPKIISIIAEGKINETINYEDPCAKRLANVVRQVQTSEDLWLECVSQLDDEQQEALQELLNFA", "function": "May function in nuclear protein import as nuclear transport receptor.", "AFDB_id": "AF-O60518-F1-model_v4" }, { "swissprot_id": "P72711", "sequence": "MVDSLATVWLIGGTVDSRAVAEGLIAQGINCLVTVTTSEAKHLYPIHQCLTVHVGALTPQEIPKFLKRHSIAVIVDASHPFAAQITTTVTAIAKEQQIPYIRFERPPLALGKNTLEVPDIQSLTRGKYQPYLRGKRVLLTVGARWLSHFSLLQDEAVLFARILPYPQALAQAIAAGFTSDRIIALRPPVAEPLEKALWQQWQIQGVVTKASGAQGGELVKQKVAEALGVNLIRIARPQTIPGQITDDLSQINQFCQRHLPS", "function": "Catalyzes the reduction of the macrocycle of cobalt-precorrin-6A to cobalt-precorrin-6B.", "AFDB_id": "AF-P72711-F1-model_v4" }, { "swissprot_id": "P45815", "sequence": "MVVIEGIKYACERCIRGHRVSSCTHTQQPLIRIKPKGRPATQCLHCREARKNKALHVKCKCGSSSSKHAATCPCYSGGGCICTNKHPQVLPPNSTTTGANGCIVINKAVLDEGSQQQAQQAQQQSQSQQAQQQQQQPQPQASPILQQPQMPTPVHTTNVTTPPVATPTHSHRALSTTPSLSPQPQSPHSPESALKSVNFLGRTNSSSSLSSLHSGRNKNRIEKVRPSHNSLSAASQLANSPSSPFYAVTPPAWVDSPTLVPTGALDASYLQILNDDLSSPLLDSDVFSSLDMEPVAHSNNNHGGIPTGGSRALASTDINFDRFESTSPSSILSSWNLWGGVGGSDAPEMSVAANPSASASASSIQTPPSSNATPEWVQGQQQPCSVSPADVMLPFKRDDQESVFLTEPLYL", "function": "Transcriptional regulator involved in resistance to high copper concentration.", "AFDB_id": "AF-P45815-F1-model_v4" }, { "swissprot_id": "P53526", "sequence": "MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLMKSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVEGLTQPVRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVASTRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAASLDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG", "function": "Could possibly oxidize fatty acids using specific components.", "AFDB_id": "AF-P53526-F1-model_v4" }, { "swissprot_id": "Q755Y8", "sequence": "MSRNFYNYDPTVDILQPPLIPDVILKSNLKELTLPTGNQVLESLPLTAWFHRTRSNIISHLTRYEAEWETQKSAARNELHSVKSYLKGNIFNDARELYALPETNILTICAYFAGRIITNRKNWGVSAATLQSVKSSVHRPSLMARVCTSIPSKMVLPWAMAGAVFKELAPTAFDNTITSLESDILDPGFVAQYKTLWRDYYTNGAKKASIEAAELLEGKLQGYIGFARNFIIYSTR", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.", "AFDB_id": "AF-Q755Y8-F1-model_v4" }, { "swissprot_id": "C5DL84", "sequence": "MSTTVRVVLDPPSNGEFYTLEDVIAGSVVLGLEKSVNIREVMVKLVGQSEAVVRPGDHLENEKPQSLQVPLSDNRSLHEVVKLESSVFPPENVKAAMKGSRKPFKVEKGEYKFPFEFHFPSRPQCIQRHQRKLFTYLKGRTNPKLPPSFNNLLSSKDVLNLNAYFYSLGCIEYFVEATVFTGGDEMWFKPFRSYPALKRTFEFIPSNVAQEHLEDALRENPNTPPQVFRSKFDVTFEGSEQQMWVEVRSKHLRSVYRLDYLFRPSGKKFNQVFLCMLNPLPESADLRVARVELNLIEVVTYLAGNRSNANLSSLRLAGVDTDYKVDLTKCQQTESGFTECHVELSDIYPLDMIRFNEEDYKHNGNRLYSFDSCNIRRRFKFQLFLHWTLNGVDHFQTEVLTNFTNIFCESVTVAEQPPDYMEEQLPKYE", "function": "May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.", "AFDB_id": "AF-C5DL84-F1-model_v4" }, { "swissprot_id": "E5AE42", "sequence": "MPFTLTLKPKKAKGGQVYYPLQLNVVSKPAPGPNEVLIQLEAAALNHRDFFLRQNLYPGLSFKSPMLSDGCGTVVELGPGCTTASNQLLGKKVILTPFRGWDSDPEGPEDYSNFSTIGGVEPHFDLGMAQNYISVHESEVELLPEHLNHIEGAALPCCGITAWRALVTKSGNAKPGRNILVTGIGGGVAIQTLLFGVAMGCNMYVSSSSDEKLAKARELGAVGTVNYKTDSDSWDKTLGSLLPAERPYLDAVIDGAGGNIVTKALTVLKPGGVIVCYGMTVGPVMDWPMQAALKNVDLRGTMVGSRAEFREMVEFISTHKIKPVISRTVRGLDCVDAIDGLFEDIRTGKQFGKLVIEI", "function": "Zinc-type alcohol dehydrogenase-like protein; part of the gene cluster that mediates the biosynthesis of phomenoic acid, a long chain aliphatic carboxylic acid that does not appear to be essential for pathogenicity but may play a role in allowing to outcompete other fungi in the environmental niche via its antifungal properties. The polyketide synthase produces the long methylated aliphatic carboxylic acid chain of phomenoic acid (Probable). The cluster-specific cytochrome P450 monooxygenase may then hydroxylate the methyl group of carbon 31 (Probable). The putative dehydrogenase YogA, which has no obvious role in phomenoic acid biosynthesis, may further modify phomenoic acid to produce a compound not identified yet (Probable).", "AFDB_id": "AF-E5AE42-F1-model_v4" }, { "swissprot_id": "Q6ZXC3", "sequence": "MPSIQLPVLLLCLTLSGVCLNGRQFPPELSENMGRSSLDDILQRSGSHMLQSVLKKVEKKEEMNKELNMPLPQWLSKRQHPGKRYISDPEKRQHPGKRDVEEKASFGDIQKRQHLGKTEVEGYLVNYLELKKRQHPGRRSLWDQSTDISSSQLTYLNELSKRQHPGRRYLMYKHQHPSKRGWNDELDLSDQNWEKHQQFGNRDRDSDSPDYTGPCDLQQSAICNKDSLLLDLAEKFSKEGVEEKHQHPGRRSAWENETEE", "function": "Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.", "AFDB_id": "AF-Q6ZXC3-F1-model_v4" }, { "swissprot_id": "P27470", "sequence": "MEKNVRFKMHKVKKRWVTLSVASATMLASALGASVASADTDTASDDSNQTVVTGDQTTNNQATDQTSIAATATSEQSASTDAATDQASAAEQTQGTTASTDTAAQTTTNANEAKWVPTENENQGFTDEMLAEAKNVATAESDSIPSDLAKMSNVKQVDGKYYYYDQDGNVKKNFAVSVGDKIYYFDETGAYKDTSKVDADKSSSAVSQNATIFAANNRAYSTSAKNFEAVDNYLTADSWYRPKSILKDGKTWTESGKDDFRPLLMAWWPDTETKRNYVNYMNKVVGIDKTYTAETSQADLTAAAELVQARIEQKITSENNTKWLREAISAFVKTQPQWNGESEKPYDDHLQNGALLFDNQTDLTPDTQSNYRLLNRTPTNQTGSLDSRFTYNPNDPLGGYDFLLANDVDNSNPVVQAEQLNWLHYLLNFGSIYANDADANFDSIRVDAEDNVDADQLQISSDYLKAAYGIDKNNKNANNHVSIVEAWSDNDTPYLHDDGDNLMNMDNKFRLSMLWSLAKPTDVRSGLNPLIHNSLVDREVDDREVETVPSYSFARAHDSEVQDIIRDIIKAEINPNSFGYSFTQEEIDQAFKIYNEDLKKSDKKYTHYNVPLSYTLLLTNKGSIPRVYYGDMFTDDGQYMANKTVNYDAIESLLKARMKYVAGGQAMQNYQIGNGEILTSVRYGKGALKQSDKGDATTRTSGVGVVMGNQPNFSLDGKVVALNMGAAHANQEYRALMVSTKDGVATYATDADASKAGLVKRTDENGYLYFLNDDLKGVANPQVSGFLQVWVPVGAADDQDIRVAASDTASTDGKSLHQDAAMDSRVMFEGFSNFQSFATKEEEYTNVVIANNVDKFVSWGITDFEMAPQYVSSTDGQFQDSVIQNGYAFTDRYDLGMSKANKYGTADQLVKAIKALHAKGLKVMADWVPDQMYTFPKQEVVTVTRTDKFGKPIAGSQINHSLYVTDTKSSGDDYQAKYGGAFLDELKEKYPELFTKKQMSTGQAIDPSVKIKQWSAKYFNGSNILGRGADYVLSDQVSNKYFNVASDTLFLPSSLLGKVVESGIRYDGKGYIYNSSATGDQVKASFITEAGNLYYFGKDGYMVTGAQTINGANYFFLENGTALRNTIYTDAQGNSHYYANDGKRYENENGYQQFGNDWRYFKDGNMAVGLTTVDGNVQYFDKDGVQAKDKIIVTRDGKVRYFDQHNGNAVTNTFIADKTGHWYYLGKDGVAVTGAQTVGKQKLYFEANGQQVKGDFVTSDEGKLYFYDVDSGDMWTDTFIEDKAGNWFYLGKDGAAVTGAQTIRGQKLYFKANGQQVKGDIVKGTDGKIRYYDAKSGEQVFNKTVKAADGKTYVIGNDGVAVDPSVVKGQTFKDASGALRFYNLKGQLVTGSGWYETANHDWVYIQSGKALTGEQTINGQHLYFKKDGHQVKGQLVTGTDGKVRYYDANSGDQAFNKSVTVNGKTYYFGNDGTAQTAGNPKGQTFKDGSDIRFYSMEGQLVTGSGWYSNAQGQWLYVKNGKVLTGLQTVGSQRVYFDENGIQAKGKAVRTSDGKIRYFDENSGSMITNQWKEVNGRYYYFGNDGARIYRGWN", "function": "Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.", "AFDB_id": "AF-P27470-F1-model_v4" }, { "swissprot_id": "Q22549", "sequence": "MVLAAVLSMLRYVGGSDDRDFVDRLHSYFTCNLLIGLAVLVSFKQFGGKPVECLVPDIFSSSWEQYAENYCWASDTYYVPTNEPVAGLQSDEKRQRKISYYQWVPFFLLLEAACFRLPSLLWKYLAGHSGIKINEIVKLSSDPNNIKPDIKRANIKSLTVHLQGALRFHRRLQKKQIRPHRFLWLFNLPYSAFFVTAMYLCTKFFYLANVCLQLMFMNRFLETDKYKWYGMGALVDLLNGTTWEQSGMFPRVSLCDFDVRVMGNMQEHTIQCVLVINIFNEKIFILLWFWYLALLVFTFGSFFYWLLVSLWRHLNVRFIIRHLEMSDIAFDSSEDGAQEKVNRFISNYLKSDGVFVIRMMTLQSGVIFGTDLVQELWRNFHGSEPQLKRSNSAPKIEEREQWWPAYPSLVNPINPWRYRDENQANALRWRRALGANVDNSIATQDLMEKLLPQNAHMRPSDDELLNRQPIAVQASYIDDESDGKLKNEEKQNQQNATQPPYCYTNQNPTPYQNQNQIQNQNQYSNYYRTPSLSRGTDSRPVSTATDTDQTKKQSMSTFK", "function": "Structural component of the gap junctions.", "AFDB_id": "AF-Q22549-F1-model_v4" }, { "swissprot_id": "A2YUQ6", "sequence": "MAMAAAASLLPACAAPTLPGRAFRPRRNSTPTASLSCDGGSRGRGVGLGVILGGGRAQGVRRNAAAETYVPGSGKYIAPDYLVKKVTAKELEELVRGERKVPLIVDFYATWCGPCVLMAQDIEMLAVEYENNALFVKVDTDDEYELARDMQVRGLPTLYFFSPDQSKDALRTEGLIPIDMIRNIIDNEL", "function": "Probable thiol-disulfide oxidoreductase that may play a role in proper chloroplast development.", "AFDB_id": "AF-A2YUQ6-F1-model_v4" }, { "swissprot_id": "A0A084API1", "sequence": "MTIPTSFEMLKGMHIKDAFLLIAMLYLGYLLCICFYNIYLHPLRHIPGSKLAVMGPYLEFYHEVIRQGQYLWEIEKMHDKYGPIVRVNEREIHIRDSSYYHTIYAAGSRKTNKDAATVGAFDVPNSTAATVDHDQHRARRGYLNPYFSKRSLANLEPTIHERISKLLNRLEQHQNNDDIITLDGIFSALTADVICSRFYGKHFDYLSIPDYHFVVRDGFQGLTKLYHLGRFLPTLVTILKCLPQQIIRLILPNLADLIVMRDEIQANGIAQFTSSQTADSKASALVGALGDKNIPPHERTVARLLDEGTVFLFAGTETTSRTLAVTMFYLLTNPDCLKKLRAELDTLPSTEDYQHSLSTLESLPYLSGVVHEGLRLAFGPITRSARVPMNVDLQYKEYTIPAGTPLSMSTYFVHTDKELYPEPEKFKPERWIQAAEENIPLKKFLTNFSQGSRQCIGISMSFAEMYLTISRVARAYNFELYETTAADLDMTYARIVPYPKEIPGKTEGLGEIRVKIVGKNHSQIEE", "function": "Cytochrome P450 monooxygenase; part of the satratoxin SC2 cluster involved in the biosynthesis of satratoxins, trichothecene mycotoxins that are associated with human food poisonings. Satratoxins are suggested to be made by products of multiple gene clusters (SC1, SC2 and SC3) that encode 21 proteins in all, including polyketide synthases, acetyltransferases, and other enzymes expected to modify the trichothecene skeleton. SC1 encodes 10 proteins, SAT1 to SAT10. The largest are SAT8, which encodes a putative polyketide synthase (PKS) with a conventional non-reducing architecture, and SAT10, a putative protein containing four ankyrin repeats and thus may be involved in protein scaffolding. The putative short-chain reductase SAT3 may assist the PKS in some capacity. SAT6 contains a secretory lipase domain and acts probably as a trichothecene esterase. SAT5 encodes a putative acetyltransferase, and so, with SAT6, may affect endogenous protection from toxicity. The probable transcription factor SAT9 may regulate the expression of the SC1 cluster. SC2 encodes proteins SAT11 to SAT16, the largest of which encodes the putative reducing PKS SAT13. SAT11 is a cytochrome P450 monooxygenase, while SAT14 and SAT16 are probable acetyltransferases. The SC2 cluster may be regulated by the transcription factor SAT15. SC3 is a small cluster that encodes 5 proteins, SAT17 to SAT21. SAT21 is a putative MFS-type transporter which may have a role in exporting secondary metabolites. The four other proteins putatively encoded in SC3 include the taurine hydroxylase-like protein SAT17, the O-methyltransferase SAT18, the acetyltransferase SAT19, and the Cys6-type zinc finger SAT20, the latter being probably involved in regulation of SC3 expression.", "AFDB_id": "AF-A0A084API1-F1-model_v4" }, { "swissprot_id": "Q94464", "sequence": "MDQLIPVINKLQDVFNTLGSDPLDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGIVTRRPLILQLTHLPIADDGSQTQEWGEFLHKPNDMFYDFSEIREEIIRDTDRMTGKNKGISAQPINLKIYSPHVVNLTLVDLPGITKVPVGDQPTDIEQQIRRMVMAYIKKQNAIIVAVTPANTDLANSDALQLAKEVDPEGKRTIGVITKLDLMDKGTDAMEVLTGRVIPLTLGFIGVINRSQEDIIAKKSIRESLKSEILYFKNHPIYKSIANRSGTAYLSKTLNKLLMFHIRDTLPDLKVKVSKMLSDVQGELSTYGDPLYDTKNSQGALLLQIITIFSSNFKDAIDGKLTDLSNNELYGGARISYIFNEIYSHCVNNIDPLEGISLNDIRTTMRNATGPRAALFIPEISFELLVKKQVVRLEEPSAQCVEYVYDELQRIVSQLEAKELSRFINLKARVIEVVNNLLQKHKVPTKTMIEHLIKIETAFINTSHPDFVGGEGIFESLYKKQQLQQQNHLQQLQDQYQQQQQQQQQQQQQNGINNNQKGDNGNMNVNQQNMNQQNMNQQNQSTNPFLQQQQQGQNKYPGGPPAQQQPNQQPNQLNKGPQNMPPNQSKPSSIPQNGPNNNNNNNNNNNRQDHQQGSFFSSFFRASPDPSLGQYGGANNSNNSNNPTSPINSSSNSGNNYNTFGGQQSSSSSSQQLQQSSQSQYKTSYNNNNNSSSNNSSYNRYQDDFYGRGDKLNQVPSIIKAPDDLTSKEKFETELIRELLISYFNIVKKNVKDSVPKSIMHFLVNQSKEHIQNELVAALYKEELFDELLEESPQISSKRKSCKAMIEILRKANEIINEIRDFRN", "function": "Function in membrane trafficking processes along the endo-lysosomal pathway.", "AFDB_id": "AF-Q94464-F1-model_v4" }, { "swissprot_id": "Q88X36", "sequence": "MKKSERQAVIEQLISEYPIATQEELMAKLKAEGIAATQATISRDIREMQIVKTPDEHGQTRYAIFKTTNKNEQDRLFETLHDVVTSIDRVEFMNIIHTLPSNGNLLAAIIDDLNLPEVSGTLAGHDTIFVVSPNTTVAKQLYESFASHISNED", "function": "Regulates the transcription of the arc operon, involved in arginine catabolism.", "AFDB_id": "AF-Q88X36-F1-model_v4" }, { "swissprot_id": "O27590", "sequence": "MSLYREVDAFRVDDERRRVPEKVVNDIEVRIRINGGMEQRFTASPQALEEFATGYLLGEGLVDSVDDIVSIEISDNIIDAEIESGDLDIRRELVMGSDCFGGWRQRVEMVGPVDSDLRVRADDIFLAFKRMVKSAVVWRMTGGTHVAALVTGDEFRVFEDVSRHVAVDKVIGSGAMDGVNFRESFIVYSGRMPADMLIKVVRAGVPIIASNAAPTSSGYDAAQRTGLTMLGFVRGKRFNIYSHPERII", "function": "Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.", "AFDB_id": "AF-O27590-F1-model_v4" }, { "swissprot_id": "A5JYS0", "sequence": "MSQRRHFKMSVTAKNFYRRPLPETCIEFSSELGKKLFTEALVRGSANIYFKLASQFRTQDEPAYCGLSTLVMVLNALEVDPEKVWKAPWRFYHESMLDCCVPLENIRKSGINLQQFSCLAKCNRLKSTVSYGDNSPDFLKKFRTSLVNSVRSDDQVLVASYDRSVLGQTGSGHFSPLAAYHEDSDQVLIMDVARFKYPPHWVKLETLQKALCSVDVTTKLPRGLVELELKKGTRPLIMYGLKAYVNINDSDFATSVISWNQFLLCDPLEDDEEEFQLCCRKFGQCFAPHAMCCTQKTFDADQKNSCTECSTDQNEACKMICSEIRRTRFAEVFSSSAVAALLIAWPFEKGYSERSDRIGNLAEKYKNEFSAETMNEMNQLTTQIRTLISCSKPPVVININKPDATSNKCCKNKIGQSCACANDVNL", "function": "Involved in the synthesis of phytochelatins, which are heavy metal binding proteins required for the detoxification of heavy metals such as cadmium, arsenic and copper.", "AFDB_id": "AF-A5JYS0-F1-model_v4" }, { "swissprot_id": "P96582", "sequence": "MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLESFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAACYMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG", "function": "Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.", "AFDB_id": "AF-P96582-F1-model_v4" }, { "swissprot_id": "Q9FJL3", "sequence": "MEDDFDTQNQFPEEEPEEMDMDLPDNDEADSAPYLKIGEEMEIGKSGLKKKLVKECEKWDTPENGDEVEVHYTGTLLDGTKFDSSRDRGTPFKFTLGQGHVIKGWDLGIKTMKKGENAIFTIPPELAYGETGSPPTIPPNATLQFDVELIAWRSVKDICGDGGVSKKIIVEGEKWEKPKDLDEVYVKYEARLEDGTIVGKSDGVEFTVKEGHFCPALSKAVKTMKRGEKVLLTVKPQYGFGEFGRPASDGLQAAIPPNATLQIDLELVSWKTVVEVTDDRKVIKKILKEGEGYERPNEGAIVKLKLIGKLQDGTTVFVKKGHEEDEEPFEFKIDEEQVIEGLEKAVMGMKKGEVALITISPEYAFGSSESKQELAVIPPNSTVYYEVELVSFIKEKESWDMNTQERIEAAGKKKEEGNVLFKAGKYARASKRYERGVKYIEYDSTFDEEEKKKSKDLKIACNLNDAACKLKLKDYKEAAKLSTKVLEMDSRNVKAMYRRAHAYLETADLDLAELDIKKALEIDPDNKEVKIEYKKLKEKVKEYNKKDAKFYSNMLSKMLEPHKGTQKEAQAMSIDTKA", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Co-chaperone that negatively modulates thermotolerance by interacting with FKBP62 and decreasing the HSFA2-mediated accumulation of chaperones of the small-HSPs family. Plays a positive role in tolerance to intracellular acid stress by maintaining the pH homeostasis. May be a part of transcription regulation pathways upon pathogen infection.", "AFDB_id": "AF-Q9FJL3-F1-model_v4" }, { "swissprot_id": "Q9T003", "sequence": "MSSDQLSKFLDRNKMEDNKRKVLDEEAKASLDIWKYVFGFADIAAAKCAIDLKIPEAIENHPSSQPVTLAELSSAVSASPSHLRRIMRFLVHQGIFKEIPTKDGLATGYVNTPLSRRLMITRRDGKSLAPFVLFETTPEMLAPWLRLSSVVSSPVNGSTPPPFDAVHGKDVWSFAQDNPFLSDMINEAMACDARRVVPRVAGACHGLFDGVTTMVDVGGGTGETMGMLVKEFPWIKGFNFDLPHVIEVAEVLDGVENVEGDMFDSIPACDAIFIKWVLHDWGDKDCIKILKNCKEAVPPNIGKVLIVESVIGENKKTMIVDERDEKLEHVRLMLDMVMMAHTSTGKERTLKEWDFVLKEAGFARYEVRDIDDVQSLIIAYRS", "function": "Methyltransferase which catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Does not seem to possess caffeate O-methyltransferase activity.", "AFDB_id": "AF-Q9T003-F1-model_v4" }, { "swissprot_id": "A7EJ50", "sequence": "MSCSCTKRTLQLFIRNVAQVELAASSTSTYPPQRTNFQRFNVPSLPSLHPSHSRAYWSAYSSEPRRDTVEDAPIENQEGPPSATEGHINTTPEKIDDMDDLFMEITPESLDALAAETSSGLANSQSRESKELKQPWQAEKSRKFIDPEETTEETWTQGEPIDIFSKPMKKPRWDKPVESLRFRSIKIDNAVAVPYSPQASTSKRNMVRDDWTPPDRKTWMEQKAALKEKFPEGWKPMKKLSPEAQAGIRALHAQYPEQYSTPALADRFQVSPEAIRRILRTKWVPKPEEEADRERRWFQRGKSVWGRYAELGVKPPKRWREEGIGRGKPEWKKRAAPVLTTSRPGTSEPRRPETISLDDQMEDRIF", "function": "Required for respiratory activity and maintenance and expression of the mitochondrial genome.", "AFDB_id": "AF-A7EJ50-F1-model_v4" }, { "swissprot_id": "P74839", "sequence": "MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYARSRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQLLPELMVNTAELTPSTVDANALQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSDN", "function": "Involved in the transcriptional regulation of the propionate catabolism operon.", "AFDB_id": "AF-P74839-F1-model_v4" }, { "swissprot_id": "Q9PUT6", "sequence": "MTAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTNKFSCRVAQYPFEDHNPPQLELIKPFCEDLDQLLSENENVAAIHCKAGKGRTGVMICAYLLHRGKFPRAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNSLEYRPVPLLFHKIEFETIPMFSGSTCNPQFVVYQLKVKIFTSTAGPKRAEKLMYFDFPQPLPVCGDIKVEFFHKQNKVMKKEKMFHFWVNTFFIPGPEEYSEKVENGTLVGEQELDGIYSTERSDNDKEYLTLALTKNDLDKANKDKANRLFSPNFKVKLFFTKTVEESSNSEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQITQITKV", "function": "Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.", "AFDB_id": "AF-Q9PUT6-F1-model_v4" }, { "swissprot_id": "P44629", "sequence": "MQVRPFYWLALSFLGYYCAYGVFLPFFPAWLKSQQYGEEMIGLVIGSAYIFRFAGGLFFSSLIKKANHIIIALRLLALASAIIMAAMSLVAHNFWLLFIAIGLYASVNSAGMPIGDSLASTWQRQIGLDYGKVRLIGSAAFILGVVVFGGMIGWVGEQNIVWILTALLSFYTIIQLLKPTIPPKDEIPEDSVQNDVGFIALLKNPMTLRVMIAVGLIQGSHAAYYVYSTIYWTSIGISVSQTSLLWGIGVLAEIVLFFFSRRLFQNISISVLLYISALACVGRWAVIGYIEDFWLIFLLQLMHSLTYAVCHYAIVRYITTQPQSHIAKLQGLYNGLSNGVLIAIFTAIAGMIYPTSPAMTFVFMSIIAAAAFFVIPRKLNAFLIVQHK", "function": "Probable permease involved in the uptake of 3-phenylpropionic acid.", "AFDB_id": "AF-P44629-F1-model_v4" }, { "swissprot_id": "Q96JG8", "sequence": "MAEGSFSVQSESYSVEDMDEGSDEVGEEEMVEGNDYEEFGAFGGYGTLTSFDIHILRAFGSLGPGLRILSNEPWELENPVLAQTLVEALQLDPETLANETAARAANVARAAASNRAARAAAAAARTAFSQVVASHRVATPQVSGEDTQPTTYAAEAQGPTPEPPLASPQTSQMLVTSKMAAPEAPATSAQSQTGSPAQEAATEGPSSACAFSQAPCAREVDANRPSTAFLGQNDVFDFTQPAGVSGMAFPRPKRPAPAQEAATEGPSAASGVPQTGPGREVAATRPKTTKSGKALAKTRWVEPQNVVAAAAAKAKMATSIPEPEGAAAATAQHSAEPWARMGGKRTKKSKHLDDEYESSEEERETPAVPPTWRASQPSLTVRAQLAPRPPMAPRSQIPSRHVLCLPPRNVTLLQERANKLVKYLMIKDYKKIPIKRADMLKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYILVCTRDSSARLLGKTKDTPRLSLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPFLGDLRKLITDDFVKQKYLEYKKIPNSNPPEYEFLWGLRARHETSKMRVLRFIAQNQNRDPREWKAHFLEAVDDAFKTMDVDMAEEHARAQMRAQMNIGDEALIGRWSWDDIQVELLTWDEDGDFGDAWARIPFAFWARYHQYILNSNRANRRATWRAGVSSGTNGGASTSVLDGPSTSSTIRTRNAARAGASFFSWIQHR", "function": "May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.", "AFDB_id": "AF-Q96JG8-F1-model_v4" }, { "swissprot_id": "O14210", "sequence": "MARRRSTRRALVETPSDLNAQDSDSLSVSTKEELGDDALAAEEGQSVLDEQEIEEALEEDDTNYEEDIIDDEESAQVDEEELEEEEEEEEDATPEPVVTSKKNSRSKPKNGGASKRKASRRTVVDEDSENLEGDEEDGSFSDLKDLYSNPMPAQTTPVSMRMTKRQRAIQGILEEGEEDELLELPPETSGRKKLTPEEMALRRIENARRRKNQSERRLEEEKMETINRLLKRQSNTGKPRRGRAPNNPTSDSISRSKAVPKDRINMYQPFQCVRFKSTKEGSSLGVPEPLIRFFS", "function": "Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.", "AFDB_id": "AF-O14210-F1-model_v4" }, { "swissprot_id": "Q9BVS5", "sequence": "MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDGEREHEAAQRKAPGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPRELEDSSGDQGRCGPTHQGSEDPSMLSQAQSATEVEERHVSPSCSTSRERPFQAGELILAETGEGETKFKKLFRLNNFGLLNSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALEDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELFQEDDHEESHSDFPYGSFPYVARPVHWQPGHTAFLVKLRKVKPQLN", "function": "Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function. In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation.", "AFDB_id": "AF-Q9BVS5-F1-model_v4" }, { "swissprot_id": "Q6Z3A8", "sequence": "MSSFDSVAAVAGDGDADDDDVLPPAPFDPAADGAQGGLGALRRGHRFATSYSSFGTAASEDDLAGAGAGTDGGVGAGIPLGSSSNGGAAYGYGGSGDVMNGHVDQIGDVMGGGVVVGDGGGIDDDLFAGAGDGDDGPVLPPPEAMKEEGILRREWRRQNALMLEEKERKERERRGEIIAEADEFKRSFAEKRKLNGDTNRAQNRDREKLFLAKQEKFHGEAEKQYWKAIAEMVPHEIPGLEKRGKRREKQSAEANAKAKQPGVVVVQGTKPGKPTDLSRMRQVLMKLKQTPPPHMAPPPPQPAKDTGGDTDANKDGEAEKAAGEIEKKAAGGEKEAAAGPPVTAAAAADAQANKAAAEETAKK", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.", "AFDB_id": "AF-Q6Z3A8-F1-model_v4" }, { "swissprot_id": "Q9WZJ0", "sequence": "MGTVLIHVCCAPDLLTTIFHVRDAEFFFYNPNIQPLSEYEKRREAVDKVANHFSLNVRYGEYSTEEIRKWYTAVKDYKDLGEGSKRCERCISFLLERTAQEARKRGHESFSTTLLASPRKNLPMIENIGKTIEEKYGVKFFFKNFRKGGAYQEGVRLSKELGIYRQNYCGCVFSLLERREKHAEISRKRGHM", "function": "Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).", "AFDB_id": "AF-Q9WZJ0-F1-model_v4" }, { "swissprot_id": "F6TQD1", "sequence": "MASWVFCNRCFQSPHRKSSFSLTSCGHVYCHSCLLKGTKNECVICQAPCQTVLLSKHTNSNIQTFFLGIDGLCKKYSQETSQISEFQEKHRRRLVAFYQEKISQLEESLRKSVLQIKQLQSMRSSQQPAFNKIKNSVSTKPNGYLFLPPNSSLPDRIESMDIDLTPPARKPEMSAGPSRISVISPPQDGRMGSVTCRGPQHLSLTPSHASMTKASRVPPLQMPYKELSPPPASQLSSRATQGPSPSVSSSWTGPPRQPISISGLLQRQCAGSASPRGMDTEKMSPFLPSTPTNLRSVASPWHACVHR", "function": "SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.", "AFDB_id": "AF-F6TQD1-F1-model_v4" }, { "swissprot_id": "G0S616", "sequence": "MPKSKRARVYHLTQVNKKGREAKERLFSNIRETIPKYQHCFVFSVDNMRNNYLKDVRHELNDCRIFFGKTKLMARALGTTPEEEQADGLHRLTRYLTGTVGLLFTNRDPADIESYFSNLSQVDFARAGTVAPRTVTVPPGIVYSTGGEVPPEHDVPVSHTLEPELRRLGMPVRMIKGKVCLGDEKGEASEGYTICKEGEVLDSRQTRLLKLFSICLSEFKVSLLGYWSSASGEVTELEAGKTRPKREGNRRQAMNGDEMDEDQSSDEDSD", "function": "Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.", "AFDB_id": "AF-G0S616-F1-model_v4" }, { "swissprot_id": "P75177", "sequence": "MRKVLYQKYRPTKFSDTVGQDSIKRIIVNAITQDQLPHGYIFAGERGTGKTTFAKIIAKAINCLNWNGDVCNQCEACQAINSNSAIDVFEIDAASKNGINDIRELAENVFNLPFKFKKKVYILDEAHMLTPQSWSGLLKTLEEAPDYVLFIFATTEFNKIPITILSRCQSFFFKQITNDLIQQRLAEVAAKESIKITTDALVKLADLAQGSLRDGLSLLDQISNFSESKTISLADVEKTFNLLDKEQKFGFIEAVLSGDLKQSFHLIDNFESQGINFVHFLRELFALTVDLYGYVKTGQIAVVKPSDQTMAAKLRFHPKQYALLVQAIEANTGYGPSQLSLSDQIKAIVIHYNNAVSKEPHIPAYTPVVQTQSPAKEHVPSKTVEEAKPQLPAKEPVLYKVIEEPKVSSFVKDPVASKLIEQPQTIVQPEAQQEITEVEQPTETSPAPATDLFGLAIKPEVVRKRGRRPLSVENTDFFQPAVKKLIQPVSKPAPIKLIEPSDNNPVSIPIKLNRAVIAVSVYGHNDPKLVAHFQQLLDSFKREFTQAEKTKDSSYLKQFSDKFTASDLSKVIKVLAASPFGLVLIFEDKEIATRLWKEALTEATAQATLLEIFQQNLFLSSFTLSEYETKVLAKVEQLTHKPQVLQLQQLEQLSSTVVKKAQKTAAQEIADTFFKGLYEEK", "function": "DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.", "AFDB_id": "AF-P75177-F1-model_v4" }, { "swissprot_id": "Q04082", "sequence": "MYTKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTLLDIFPQRRWIITLESIMLMGMLCTYIGLLMYNEDTLTPPLDSLSTVTDAGGQLVIEDDPDVFVKKWAFKETSGIYDLSLMDACQLLYLYDNDHTST", "function": "Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Involved in cell wall biosynthesis.", "AFDB_id": "AF-Q04082-F1-model_v4" }, { "swissprot_id": "O06825", "sequence": "MRAVFGCAIAVVGIAGSVVAGPADIHLVAAKQSYGFAVASVLPTRGQVVGVAHPVVVTFSAPITNPANRHAAERAVEVKSTPAMTGKFEWLDNDVVQWVPDRFWPAHSTVELSVGSLSSDFKTGPAVVGVASISQHTFTVSIDGVEEGPPPPLPAPHHRVHFGEDGVMPASMGRPEYPTPVGSYTVLSKERSVIMDSSSVGIPVDDPDGYRLSVDYAVRITSRGLYVHSAPWALPALGLENVSHGCISLSREDAEWYYNAVDIGDPVIVQE", "function": "Probable L,D-transpeptidase that may perform as-yet-unknown cross-linking reactions in M.tuberculosis. Is not able to generate 3->3 cross-links in peptidoglycan, using tetrapeptide stems as acyl donor substrates. May function in the anchoring of proteins to peptidoglycan.", "AFDB_id": "AF-O06825-F1-model_v4" }, { "swissprot_id": "G5EC37", "sequence": "MTPLSALTSNPAPSPPPKFALGKCPATAIHVVSVLRPNRQRFCYEKTDAGDLIPHKCLICQPILTEKHISPYYAVYSDLLEDFVLFGYNTMTGKMEQFIYAFKTDCFVEVNRPEIKYNPAFLVKGNVVVALNGPEGELVVIERDCRGLLSKESTSYGQFRTLPTAALRTLTLQDLERDRWDRAANSDEVKISSGNESFDRLYAEYQKNLPRFQVRQCLHLNKEFLCVYSKTSGDYTRLEYIDETGDFQKISCTLCTCEVTESNLIPLYVERNASELVIHVHNTENNQIEQYIYDVRTFGFVQVKRNLVYDPKKITSGLNLFMAENIDNRKVYMIMRGRDGRLQKETSGSGGFEKMQPVAVKTFQVQWVEMKTEFEKKKASTERVEPQHPVQTEGEDIMETVLAMVESFNCDLRKELGLTQDQEIPRKAPRVESAETEENIVKNLEKLQIAKDPEEPTTAASEGGNTYGYQELDDTMSEGLLEKEAESKHQDANEPEPVKNVTYEPDVAAMDKKKKRRELKSRLNKINAQIDELEKRRMERAGKKQVVSSSVPSEEAAQVEAPASPALAENTNQISNEETPKIDIFEGYNGSFLFGTNTSKEWIVEDIRNHMVGKLLKAFWPRIQNVEEMNGELFKKLIANARKCETEILEASNDRDEYYRLMQLTVDQILKKTLKKDQRATEHNHQQPTQSSDELAKNHEKN", "function": "Adapter protein that connects P-granules in somatic cells with the autophagic machinery. Association with other adapters such as epg-2 and P-granule components such as pgl-3 is required for the accumulation and degradation of P-granules by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells.", "AFDB_id": "AF-G5EC37-F1-model_v4" }, { "swissprot_id": "Q0WTP1", "sequence": "MAAKQMEEIQKKLRLLSYPRANAPAQSLLFAGMERYALLEWLFFKLLGDKSPFSQQNLQGDAGVRDEETVRIQYLAEIAKFLGITPTVDIEAIQGHGTYEDRMEMLRNIVDLVEASLFSDNQEWSIDEQVAKDIQLIDAIAERQSLIFSEECKLFPADVQIQSIYPLPDVSELETKLSEQAKILSNLQQKVDDLAAKHAYNPDEEYTEVESQLRARLESFLETARAFNTIYTKEIRPWTHMMEVPQLHGFGPAANRLLEAYNMLLKFLGNLKNLRDSHAALSIGSSGTVAGEPSSVTRIVSDCEAALTVLNRDLGILSASIAREQGERL", "function": "Contributes to the assembly of the acentrosomal spindle and phragmoplast microtubule arrays as part of the augmin complex. Regulates the association of gamma-tubulin with the spindle and phragmoplast microtubules.", "AFDB_id": "AF-Q0WTP1-F1-model_v4" }, { "swissprot_id": "Q9SXA1", "sequence": "MEALTELCDIIAKNPKQFSEKLAWICGRCPQTEWLLAESPRVSRSHLNAVLAVARIISKNPESIDNRAKSVVNEFLSAIPASFRRSFWPHSFPSQLISSFYCDFLSYLSCAADLSPEFGTEVARFTGEVVIAAIAPSSGDSDGDPAISKAFLVALSQHFPSILQSDGDKLITMLLDQFVLNRAPASPKEQRQQNSANSETDTSSSQGSPISTNRYPSGKTEMASPGDEVASHGSNLSSKSSSSVVMNGGSIVWKSGVDQLSFGFSEGSGGANPVFRQQVASFEDESIESLEKQEIAFRLITHILDKVKIDSKLQDQVRFIAKRQLQSMSAFLKSRKRDWNEQGQVLKTRVNAKLSVYQAAAKMKIKSLVSLETDGKTSKRLVLETLALLLDAADACLTSVWRKMKACEELFDSLLSGIAKIAVARGGQPLRVLLIRLKPLVLAVCALPDQGAMLESIFKTSCVIIESAWAKDRAPVDNFIMGLASSIRERNDYEEQVDREKQVPAVQLNVIRLLADLNVAVKKPEVADMILPLFIESLEEGDASTPSFLRLQLLDAVSRIATLGFDKSYRETVVLMTRSYLSKLSSVGSVESKTSAPEATTERVETLPAGFLTIASGLMDTKLRSDYRHRLLSLCSDVGLAAESKSGGSGVDFLGPLLPAVAEICSDFDPTMDVEPSLLKLFRNLWFYIALFGLAPPIVKTPTPPLKSTSNSVNSVGSMSATALQAVGGPYMWDNQWALAVQRIAQGTPPLVVSSVKWLEDELELNALHNPGSRRGNGNEKVASTQRLALSTALGGRVDVAAMNTISGVKATYLLAVAFLEIIRFISNGGILNGESSVSASRSAFSCVFEYLKTPNLTPAVSQCLTAIVHRAFETAVSWLEDRISLTGKDARNRELTTYAHACFLIKSMSQRDEHVRDISVNLLTQLRDKFPQVLWHSSCLDSLLFSVHDNTPSTVVNDPAWTAAVRSLYQKVVREWIIISLSYAPCTSQGLLQDKLCKANTWQRAQTTTDVVSLLSEIKIGTGKNELWSGIRTANIPAVMAAAAAASGANLKVSEAFNLEVLGTGVVSATVKCNHAGEIAGMRRLYNSIGGFQSGSTPSGFGGGLQRLISGAFSQAPQPEDDSFNEMLIARFVRLLQQFVNTAEKGGEVEKSQFRETCSQATALLLSNLGGESKTNVEGFSQLLRLLCWCPAYISTPDAMETGIFIWTWLVSAAPQLVSLVLAELVDAWIWTIDTKRGLFASDVRYSGPAAKLRPHLSPGEPEDPPESDPVDQIVAHRLWLGFLIDRFEVVRHNSAEQLLLLGRMLQRSTDLEWCFTRHPAAAGTFFSLMLLGLKFCSCQTQGNMQKFRSGLQLLEDRIYRTSLGWFAHQPEWYDVNIPNFCHSEALSVSVFVHFLSNELSESSQSDSKGKPRESGNLIDVTDQYHPVWGEMDNYTLGKEKRKQLLLMLCQHEADRLDVWAQPISSKDSPYSRLKISSEKWTEYAKTAFSVDPRIALSVASRFPANASVKSEVTQLVQTNIVDLRTIPEALPYFVTPKNVEENSVLLQQLPHWAACSITQALEFLTPAYKGHPRVMAYVLRVLESYPPERVTFFMPQLVQSLRYDDGRLVEGYLLRATQRSDIFAHILIWHLQGEDVQETPKDGSIDKNAAFQEILPQVRQHIIDGFSPNALDMFTREFDFFDKVTSISGVLFPLPKEERRAGIRRELEKIEMQGDDLYLPTAPNKLVRGIRVDSGIPLQSAAKVPIMITFNVIDRDGDHSDVKPQACIFKVGDDCRQDVLALQVISLLRDIFQAAGLNLYLFPYGVLPTGAERGIIEVVPNTRSRSQMGETTDGGLYEIFQQDYGPVGSTTFETARENFLISSAGYAVASLLLQPKDRHNGNLLFDDVGRLVHIDFGFILETSPGGNMRFESAHFKLSHEMTQLLDPSGVMKSKTWHQFVSLCVKGYLAARRQMDGIISTVQMMLESGLPCFSRGDPIGNLRKRFHPEMSEREAAHFMIHVCTDAYNKWTTAGYDLIQYLQQGIEK", "function": "Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (Probable). Can bind to phosphatidylinositol 4-monophosphate (PI-4-P or PtdIns4P), phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2 or PtdIns4,5P2), and phosphatidic acid (PtdOH), but not to 3-phosphoinositides. May function upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway.", "AFDB_id": "AF-Q9SXA1-F1-model_v4" }, { "swissprot_id": "P53382", "sequence": "MSRTDRNAADLKSAVSTALAKVIDPELQRPITELGMVKNIDIEPGGNVQVGIYLTIASCPKKSEISKRVTKAIADVPGTAAVEVSLDVMSDEQRTKLRKKLRGDAREPMIPFAQPNSLTRVYTVASGKGGVGKSTVTVNLATAIAARGLAVGVLDADIHGHSIPRMMGSNQRPIQLESMILPPIVHEVKVISIGQFTEGNTPVIWRGPMLHRALQQFLSDVYWGDLDVLMLDLPPGTGDIAISVAQLIPNAEILVVTTPQLAAAEVAERAGSIALQTRQRIVGVVENMSGLMMPDGSRLQVFGEGGGQQVAERLSRAVGTDVPLLGQIPLDPALVAAGDSGIPIVLNASDSPVGKELLRIADGLSSRQRRLAGVSLGLDPSRR", "function": "Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.", "AFDB_id": "AF-P53382-F1-model_v4" }, { "swissprot_id": "P78722", "sequence": "MMKSFFSAAALLLGLVAPSAVLAAPSLPGVPREVTRDLLRPVEERQSSCHTAANRACWAPGFDINTDYEVSTPNTGVTRTYTLTLTEVDNWLGPDGVVKQKVMLVNGDIFGPTITANWGDWIQVNVINNLRTNGTSIHWHGLHQKGTNMHDGANGVTECPIPPKGGSRIYRFRAQQYGTSWYHSHFSAQYGNGVVGTIVVNGPASVPYDIDLGVFPITDYYHKPADVLVEETMNGGPPPSDTVLFKGHGKNPQTGAGKFANVTLTPGKRHRLRIINTSTHDHFQLKLQNHTMTIIAADMVPVQAQTVDSLFLAVGQRYDVTIDANKSVGNYWFNATFGGGLACGASLNPHPAAVFRYQGAPNTLPTNIGTPAADANCMDLNNLTPVVSRSVPTSGFTPRPNNTLPVSLTLGGTPLFVWKVNGSSINVDWDKPIVDYVIAQNTSYPPQANVITVNSVNQWTYWLIENDPTGPFSIPHPMHLHGHDFLVVGRSPDQPAGVPQTRYRFNPATDMALLKSSNPVRRDVAMLPANGWLLIAFKSDNPGAWLFHCHIAWHVSGGLSVQYLERPNDLRNGFSQADKNQHNNNCNAWRAYWPTNPFPKIDSGLKVKKWVGEHPDWYIKN", "function": "Probably involved in lignin degradation and in the detoxification of lignin-derived products in its natural habitat (herbivorous dung), which is rich in lignin of grasses and straw. Probably involved in melanin synthesis and in perithecia development.", "AFDB_id": "AF-P78722-F1-model_v4" }, { "swissprot_id": "P55610", "sequence": "MADPIVHPGVHRPEFSAPLHARAEIIATLRAALGKPNTTLVGAAIGTGMAAQAASRGGADFILALNAGRLRSMGAPSIFSLLALRKSNDFVLDFAQSEILPFVKVPVFFGASAFDPRCSIEAELERIADAGFGAIVNFPTSIFLDGRFRADIEGAGLGFQRELEMLRAAQKRNMATLAYVRTVAEAQQAATAGVDIINLNLGWNVGGTVGSRTELSLRQAAEYAKIIFRQIRAISEDTLCVLEGGPIVSPDQMYEVSALSKADGYIGGSTIDRVPLEASMEQITSAFKSVGTLQKRIDELERQLEHVQREYSIVGRSPSIQQIKQRIEKLAASSLPVMITGQAGTGKKLLARGIHEAARRSGSKLISSEDASGESLFGFAPSEGGRKVLGLLQYHPKATLLIESVECLCVDAQERLIEVIETGAYRRLGDNERGRFEGRLILASTRPLPELGSSGQLIPALESRLAPGHVFLPPLCDRLEDLPLLAEHFLQALRKDRRSRKLSVDHSAYRVLMTYGWPENIRELRSVLETAAIRCEGDWIKSEHLPPLGDANADAPHPHPGEEREWILDALQRHRFRRGEAARYLGISRKTLYNKMRVYGLPLQPRERS", "function": "Probable transcriptional regulator that acts in conjunction with sigma-54.", "AFDB_id": "AF-P55610-F1-model_v4" }, { "swissprot_id": "P16675", "sequence": "MPGTALSPLLLLLLLSWASRNEAAPDQDEIDCLPGLAKQPSFRQYSGYLRASDSKHFHYWFVESQNDPKNSPVVLWLNGGPGCSSLDGLLTEHGPFLIQPDGVTLEYNPYAWNLIANVLYIESPAGVGFSYSDDKMYVTNDTEVAENNYEALKDFFRLFPEYKDNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLASYEQNDNSLVYFAYYHGLLGNRLWTSLQTHCCAQNKCNFYDNKDPECVNNLLEVSRIVGKSGLNIYNLYAPCAGGVPGRHRYEDTLVVQDFGNIFTRLPLKRRFPEALMRSGDKVRLDPPCTNTTAPSNYLNNPYVRKALHIPESLPRWDMCNFLVNLQYRRLYQSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVDYGESGEQVAGFVKECSHITFLTIKGAGHMVPTDKPRAAFTMFSRFLNKEPY", "function": "Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.", "AFDB_id": "AF-P16675-F1-model_v4" }, { "swissprot_id": "P73515", "sequence": "MTPSLSLGQRLDDRYLIQLHLGQNSLGQQYLAQDTHRFDEPCTITVLTAPPGDKAGNLFKQQAEILYALDHPQIANFREFFALGSELYLVQDFIEGQSYFDLLKDRRLQGKAFTELEVRQWCRQLLPVLHYLHIQKICHGQISPSSIMRRTVDGLPVLVDFTHSQYYSGTPGEDRRDLHGLGLGAIALLTGEVNPNPPWENLLSSVALSQEFRQLLLKLLAWPPLVDWPTLTDNLNNLPQHFLPTVAEFNLTSTIPEQTDNGVGKSSTGEPPFPTVHQSPESSSSAKVKNMVRVDGLKGLVKKSFILLGLMAIAMALGWGAGQLWLDNQQRAALEKLAQEEPGDDVPEKTDLEIKNEIRARRLNLGISPQRFQTLMDDGLAFQLGIDPQQRLEKNPNTNGAPLSLGSPEQQMAMTITVLDALESLSREATRDFAQNNSGDRRRWIPRVNQLRLSSRSFYDLVNARFHHYLPMVSPALLGEPEFEQRPLAQVWNAMAFDSLASLEDESHYQRLSFDDTNQLNLNGTLEPGEGYAYAVTIPPTEEFSLQLTAPPTARISFYPPTGPEVILQNSAMHRWSGPTDQAGYYELVITSVAEEPIAFELELSIIPASAQPF", "function": "Lacks protein kinase activity.", "AFDB_id": "AF-P73515-F1-model_v4" }, { "swissprot_id": "Q5AML1", "sequence": "MSRFFVSGYTSDSSSEEEDLLSTSEEELLSSSDEGEDNESDSSFFGEDDDESEESSSDDEDGRPSGPAYFLKKSFLKGAGGDDSDSDSDDEGRKVVKSAKDKLLDDMKSSIEIINSNKYNNNWSIVLGEFDKFGRFLIRCNQTNLGTPKFYIKLLTSLDNSITETSNNERDDKTLKADEARAFNTLRQRIKKQIREFQVYYDLYKENPEEFDENEDEPLESVQAGLNDNVKNEADNSNVGALASNRVLSPIFHTLKTISESRGKKNIDKLEQIATLEKLLEANVSKSSPFELISIYQMLLSVRFDASSNQAFMPLEQWQKNEQDLGKLLDLLEANVDTYQVSELGSTTDDIDIEPVANAQGVKVIFGSITSSIDRLDDELTKSLQHTDPHSTEYVERLKDESTIYNLIVRGQAYVESITPEDVKYKSEQLARIVLRRLEHIYYKPKQLIKANEEEAWRNIEYNSSIVSKGSSVDEVIDQLTEFLQKQQKNKTYGKHAILFSIYYYAVNSQYEKAKELFLRSQFYSNINSAESSLQVQYNRALVQLGLSAFRAGSIEESHKILNEIVNSQRSKELLGQGFNSKFPNQATVLERQKLLPFHQHINLELLECVFMTCSLLIEIPTLAAIANNHKDSKRKNASLKSFKSKLDFHDRQFFTGPPESIKDHIVHASIALQKGDWLKSYNLLSSIKIWKLFPDNDKLLAMMKNQLQIEGLRTYIFTYKSVFKKLSIEKLQQIFQLSKDEVVSILEKMITTGNVSGGEIIDNKFISFTSTTEPQRSKLQELAIVLNEKIQLLTEKNEKTQSNGYGKKQQNKDQQNQQQQNQNQNQQQQQNQQQQQQQQSSQQQSNNILSEESANKFRYANVNSNNDEFQATA", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.", "AFDB_id": "AF-Q5AML1-F1-model_v4" }, { "swissprot_id": "Q54SW1", "sequence": "MIKTILLLLINFMLILIVNGDIWNYCDGNINPTFKINKLTLLPDPPLVGKEVTISLEGSLNEQITSGSSIFNVAFFINGGWRQLPTFHNDICKVLSCPVSAGPFTYSTSIKVPIFTPHGQYKGQLTLTDQSNRNVTCLTFQTYLK", "function": "Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.", "AFDB_id": "AF-Q54SW1-F1-model_v4" }, { "swissprot_id": "O74703", "sequence": "MSFKTRAVAESTYYIKSGAYYLAVTPERQIITQNTVYAWEVSIEGEYNYLKDPGTTHYLTDNGGQNLLNPRSDVDGKWGGGSEDQATQLINAETEKPLSVPYGQPFQTWLFVKV", "function": "May play a role in the structure of the hypha-forming fruit bodies.", "AFDB_id": "AF-O74703-F1-model_v4" }, { "swissprot_id": "Q9VR17", "sequence": "MINRRQRLEFALTLLPYDPETVQLSETQKKVEAIIARLRTDDSFTEEESDDCKVRRIQDANEFADSAMRHIEMSDSGKLSTLETLTLAAEKLLRTQRSPDQDFDDMVQDVEYSQLMRNTIQAVNEARLKLLQQWERSKRKALDLLTIEIEKVQEMDQEPEHKQSHEQDQDQEQSSEPFNAFRDGADEHNTSTPKTNDEDLGLDDDDEDYVPGGEETMGNKRKRIKKPVTSTPNAKRRCPGFEFDLDGESPMVTIGPNGTEVSRISLSAINWDMTGPSITRKLLCEIFDRDTLAHHTLSGKPSPAFRDCARPSKQQLDPLKVADLVYLMTNSLDMTPREVRTAITTKCADENKMLRSRMQRKSK", "function": "The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba1 may act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression.", "AFDB_id": "AF-Q9VR17-F1-model_v4" }, { "swissprot_id": "Q680K8", "sequence": "MTDSAYRVDTISRLAQWRIHNLSSSTYRKSDPFKMGLWNWHLSVEKSKMLLNVKLYPEVSNLTRENPPVASFALRVVSSTGERKALSHPEVIDKRIKTNEDFIWTIEVPLTGKIIIDVEFLDLKVLSQDSGELYSIWANGSTENQSQVTAVTSLGRMLTESIYTDITINASDGSIGAHRAVLAARSPVFRSMFLHDLKEKELSEINVLDMPLDACQAFLSYIYGNIQNEDFLIHRLALLQAAEKYDIADLKEACHLSLLDDIDTKNVLERLQNAYLYQLPELKASCMRYLVKFGKIFEIRDEFNIFMQCADRDLISEIFHEVLSTWKGF", "function": "May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q680K8-F1-model_v4" }, { "swissprot_id": "Q0AZ32", "sequence": "MIFGFHPLEGGYDVPMRVVGANIPYEWLIYVIMLIPVSVFLFGFWKKLEVWLLAKGEIHRNDKIAQRIWSWFVFSFAQARVIRKPLAGWMHAFLFWGFLVLFLAAGIDAMHNMISWPHLEGNFYIGFSWVVDVLGFLALIGVMVLGFVRYFQKPERLNDTKSSDGWIILLIFAILLTGYFIEGLRIAAQIKLSTTMQQIAYERAASPFGWMFASFFGSMSVDAMLMWHRLLWWFHMAIAFLFIALVPFTKLWHIFASMLNYTFRDLEPSANRMVYNIEEAETFGVENIEDFGWKDLLDLDSCIRCGRCQENCPAYNTGKHLNPKITLIQNMKAHLDAKAPYLLAAKASGAEVEEMAMTEEAAAEEVNPMEQSLLYDVVGSETIWDCTNCRACMEHCPMFIEHIPKIVEMRRNLVMWQGDMPGEAQMAFTNMERNYNPWGVGWAGRAGWLDERGVREMVNLLPEDGKEFEYLLYAGCAVSFDDRYKRVGEALVRLLNKAGVSFGYLGTEEYCCGDSARRLGNEYLYQTLVSQNLESFNNYGVKKIIVVCPHGYTALKNEYPQMGGNYEVYHYTEILAKLVAEGKLKPSKPLGVKMTYHDSCFLGRHNGVYDQPRNVLKAAGGQVIEIEKAKEFGFCCGAGGGRMWLEEEAVLKDGIQYKRINDTRTDQLLVPNPEMIVTNCPFCLTMIADGVKAAEAEESTKVFDVAEVLWKAME", "function": "Oxidoreductase involved in syntrophic growth of S.wolfei with butyrate. Is presumed to link the electron flow from butyryl-CoA dehydrogenases to the membrane, in conjunction with the electron transfer flavoprotein EtfAB. May transfer electrons to the menaquinone pool of the membrane.", "AFDB_id": "AF-Q0AZ32-F1-model_v4" }, { "swissprot_id": "A2ZLU6", "sequence": "MAGDRAEEEEGEAPPPEARAAAAVERVAAAVEAVAAGAGAGAGEYRNAYRRQLLALSRRIRLLGPFVEELRERRRGEGEGEEEERALAPLADALEAALALLRLGREGSRISLVLERDSVMKKFQGVILQLEQALCDIPYNELDISDEVREQVELVHAQLKRAKERIDMPDDEFYNDLLSVYDKNYDPSAELAILGRLSEKLHLMTITDLTQESLALHEMVASGGGQDPGEHIERMSMLLKKIKDFVQTQNPDMGPPMASRVLDSNGDSRPITIPDEFRCPISLELMKDPVIVSTGQTYERACIEKWIASGHHTCPTTQQKMSTSALTPNYVLRSLISQWCETNGMEPPKRSTQPNKPTPACSSSERANIDALLSKLCSPDTEEQRSAAAELRLLAKRNANNRICIAEAGAIPLLLSLLSSSDLRTQEHAVTALLNLSIHEDNKASIISSGAVPSIVHVLKNGSMEARENAAATLFSLSVIDEYKVTIGGMGAIPALVVLLGEGSQRGKKDAAAALFNLCIYQGNKGRAIRAGLVPLIMGLVTNPTGALMDEAMAILSILSSHPEGKAAIGAAEPVPVLVEMIGSGTPRNRENAAAVMLHLCSGEHHLVHLARAQECGIMVPLRELALNGTDRGKRKAVQLLERMSRFLVQQQEEQESQSQASAQVPPQATPEQVPENDIPEQLDSPASQYPMVV", "function": "Defense related protein that negatively regulates programmed cell death. In vitro, possesses E3 ubiquitin ligase activity.", "AFDB_id": "AF-A2ZLU6-F1-model_v4" }, { "swissprot_id": "P55303", "sequence": "MRHFWLLPAVAGIAGAQCPYLSGEMSFTQEQDNAGDTIEVTEQPIDNTLYVNDTGSYMTTDFGTPISDQTSLKAGPRGPTLLEDFIFRQKLQRFDHERVPERVVHARGAGAYGTFKSYADWSNVTAADFLSANDKETPMFCRFSTVVGFRGSVDTARDVHGHACRFYTDEGNYDIVGINFAPFFIQDAIQFPDLVHAIKPMPNNEIPQAATAHTSAWDFFSQQSTALHSALWLMSGNGIPRSFRHMNGYGVHSFRFVAANGTSKVVRTPWKSQQGVASLVWDEAQAAAGKNSDYHRQDLYNAMPNGHYPKYELQAQIMDEADMLRFGFDLLDPTKLVPEEVVPYTPLGMMELNANPTNYFAEVEQAGFQPGHVVPGIDFTDDPLLQGRLFSYLDTQLTRHGGPNFEQIPVNRPRKPVHNNNRDGFGQQQIPTNNWAYTPNSMSNGYPMQANQTQGHGFFTAPYRYASGHLVRQTSPTFNDHWSQPAMFWNSLIPAEQQMVVNAIVFENSKVNSPHVRKNVVNQLNMVNNNLAVRVARGLGLDEPSPNPTYYTSNKTSNVGTFGKPLLSIEGLQVGFLASNSHPESIKQGQAMAAQFSAAGVDLNIVTEAYADGVNTTYALSDAIDFDALIIADGVQSLFASPALANQMNSTATSTLYPPARPFQILVDSFRYGKPVAAVGSGSVALKNAGIDSSRSGVYTGSSETTEKIAKEVLEGLYTFRFVDRFALDE", "function": "Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.", "AFDB_id": "AF-P55303-F1-model_v4" }, { "swissprot_id": "O74393", "sequence": "MPKKAALDELKWKEVKLPDHLDDFDGFMGLEEIEGVDIKYQPKGAMKEVIYELPEVHEKKDKKPEKRKKDQKEASEKKKKGKRTSPTIEMTSLGSKVTSKNYNEFSTLEEEDEHNSHGVDVSAWAHFSLSPEMLGSLSKAGFSKPMPIQSLVIPEASIGFDIIGKADTGSGKTLAFGIPILEHCLRNVDAKYVQALVVAPTRELAHQICQHFELIKPSPNIRVMSITGGLAVQKQQRLLNKHPHVVVATPGRLWSVINENNLTGNFKKIKCLVLDEADRLLQKSHFEELSKLLEILGNPMHTQRQTFIFSATFDEGLQQRLKKNMKGNITEKYNSPMENMLKEVRFFGKPKFLDANPQSAVASRVLEGLIECAPAEKDLYLYYLIMRYPGKTMVFANGIEDIKRITPFLNELKVPSYPLHAQLDQKKRLQSLEKFKNNPKGVLVCTDVAARGIDIPSVTHVIHYHVPHTADMYVHRSGRTARANEDGVSILMCGPKELSQLKRLCYRLKKKIETFINFPVDMSILDILKTRVVLAHKIVNLTRKDGRVGREEAWLKSMAQELGVESSDDEDPDLPKKSESSKNKKQIAHLRSELAPLLHEKIRTGFSGRYLTSGLVNMAEKLANEEVHDNIIGMDSISALEVLQKRKK", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.", "AFDB_id": "AF-O74393-F1-model_v4" }, { "swissprot_id": "O59796", "sequence": "MSDIELHESAIPKELDSPVTTIALYNNHLYFGTEGGDVFLYNFSNFQLNESPELVKKISLVSKSRVNRILAMPFLGAVFIHHGSFAEVYKEDDLTQLYPSISFKGLVEFCHPGQRIDEKSTYLIVTNTHLKLISFQKDGIILVKNELKYPNIQTARVNGHIVCLVTENSFELLDILTFDTTPLFPIIKYDSENNGLMYKPMIVLHSNEFLLITGSPKDAIGLFVDSQGNVTRSTLTFSFYPKHVFSTSHYVFAISSSSLQIIDINTLSLVKSINLKDDESFSFISRLTSVHFCDRQIFSKFSAVNTASTSKTSDTIERASFSKPSFIFLTNKSWGFGAEAHFMNKLEFSITIGDIEAPLRRVSKRLRNPKKYGITNDVAYLQSAYLEQISALQYWKQGQYENSLSLLETSKIDPRVVISLYPDLYHSELSYIAFQGVISFRKSILSVDDTVANVLKSNELFRDTDQYTQRQMIEITKENAYIMLMRYLKNYKKNTSISEYLLSSQRDVMLAVEHSLLLLYLNMDDLAAGTKNAKELLESGLTGVEDIKDVLIQKKEYYLLSVLLATVRDHDGVLQTWKKLITGDYEDRRFNDGLIKIREYLVNDIEPSTFWEFTTWLCKHDATEGTRVLLDKTVSGSISAEDVLEHLDSSQDDVLIDYLVKSNSVTHRALLLKLCVNKLLGSLLDHNDFKNRLETAIETFRELPCMEKPTYAQYLEQLWGDMSDFSTHLSFYYLCSINLMENVEEESIDKIKDILFDIHVDNLYLFPQLEHSFYKRKKNYEKALSVLVTNIHDYKGGEAYCLQIDDVYPQCWCNLLEKCISTGDGCSDFIKELLYRRPFSYTLSYVCEQIPDHWNLNLLADFLCILQKRNAERLNESQTRLTLEKSLSQNLEELFMAINRRNVALGKNEI", "function": "Required for sorting and processing of soluble vacuolar proteins.", "AFDB_id": "AF-O59796-F1-model_v4" }, { "swissprot_id": "Q80ZQ9", "sequence": "MEELRCPEAKLAPPEVVIATEAPPPSLVDRYFTRWYKADVKGKPCEDHCILQHSNRICVITLAGSHPVLQSGKAIQRISYQISNNCSRLENKVSGKFKRGAQFLTELAPLCKIYCSDGEEYTISSCVRGRLMEVNENILHQPSLLQEKPSTEGYIAVVLPKFEESKSVTEGLLTQQQYEEVVVKRTNATATTP", "function": "Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.", "AFDB_id": "AF-Q80ZQ9-F1-model_v4" }, { "swissprot_id": "Q2HIJ8", "sequence": "MGGCCSSSRKSHLVGTPVYYYCPESFEELVPSGTRAGVGSAFTTGLLVDIGLETSIPDTFCAPAPLPYDLLLGRPQCTDSESIKGRMSGSSFETLATCEDLGESDCKTLASSVILSPRKSDFSKHQGLKILVDEEEDCCPICFEDYDVENPRLTTKCEHEFHLSCLLEWIERSDRCPICDKEVVFDDRLN", "function": "Probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro.", "AFDB_id": "AF-Q2HIJ8-F1-model_v4" }, { "swissprot_id": "P87214", "sequence": "MKTALLLKTKSQPFDPYVEAFEKYGRDTAFIPVLRHKRVHEEQLRDKLKNVRKTYCGLIVTSQRVSETLDEALKQEDETERQKILMETPIFTVGPATDDSIRRLGFQQTHGKDCGRGEVLADLIEEWYTTTKQHKPLLFLVGEKHRDIIQRKLGDDRVDSLIVYATQELENTETQIKDTIRKHPTIDWIVAFSPTSICSLLNTFELKIATIGPTTGDYLKKLGTQPNVVSPAPNPESLASSIVAFDEENSS", "function": "Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.", "AFDB_id": "AF-P87214-F1-model_v4" }, { "swissprot_id": "P12375", "sequence": "MTVLNRLHVCSLLAVSSLGMLPVGVFAAEAAMPGVDHSQMQGMDHSKMQGMDHSQMQGMDHSKMQGMDHSQMQGMDSDMTTMAPSKPAAPTQSRTPIAPVTDANRAAVYRSAKGHTVHDEAANYFLLFDQLEWQDADNGSVLNWDVNGWVGGDIDRLWIRSEGERTNGKTESAELQALWGHAISPWWDLVGGVRQDFKPGSPQTWAAFGLQGLALYNFEAEATAFLGEGGQTGLRLEGDYDILLTNRLILQPTAEVNFYGQSDPQRGIGSGLSETEVGVRLRYEIRREFAPYIGVTWNRSYGNTADFAREEGEDRSEARLVLGVRMWF", "function": "Exact function not known. Possibly mediates copper resistance by its sequestration in the outer membrane.", "AFDB_id": "AF-P12375-F1-model_v4" }, { "swissprot_id": "O07458", "sequence": "MMAKKRVATDNAADAKMELANRLFFRLYQCANMLHKTGTRAVEAEGLTTQQWAVLGALSRPTVANGMSVGDLARYLMVSRQNLTGLIGRMERDGHVAVVPDERDRRSRLVTMTKSGRHVWEVLAQPKIRAYYGEVLGDFSINDVTHTLHYLLKILDNMKRLDDGAAGETAATDLE", "function": "Transcriptional activator of genes for the anaerobic degradation of benzoate.", "AFDB_id": "AF-O07458-F1-model_v4" }, { "swissprot_id": "Q6NM73", "sequence": "MGLSISFLSIIMMMCLLFPDLNVVVKSATTEYTTLIYKGCARQQFSDPSGLYSQALSAMFGSLVSQSTKTRFYKTTTGTSTTTITGLFQCRGDLSNHDCYNCVSRLPVLSDKLCGKTIASRVQLSGCYLLYEVSGFSQISGMEMLFKTCGKNNIAGTGFEERRDTAFGVMQNGVVSGHGFYATTYESVYVLGQCEGDVGDTDCSGCVKNALEKAQVECGSSISGQIYLHKCFIAYSYYPNGVPRRSSSSSSSSSSSSSGSSNSDPSTSTGATGKTVAIIVGGAAGVGFLVICLLFAKNLMRKKHDDY", "function": "Modulates cell-to-cell trafficking.", "AFDB_id": "AF-Q6NM73-F1-model_v4" }, { "swissprot_id": "Q6BZZ6", "sequence": "MLKALGLGKRGGDMPTKPLNNSTVSLAIMDDALRVEEAFIAMDMVMDDRSKEALKLIQKDEPGSSGKSVAREQSAFYKLVIGVIYFIEATLGFEPESIRRASEALAEAEAAAVRQKRNVSNNGAHVSYSKYPPGTEYRVAFAEAELMGAITLFLSESYLESVKALYKLRKAYQTLDEISKSIRESKKPAKSSDHKSTLDSLSLAVSDDQEMASLVEKFQKTRLNRLNESNNATPVASSAASMNTTTSSATALHQGSETIEEFIESGVDLCFGILQLVISIIPPTLGKILSVVGFRGSRDGGLSLLWEATNYRNIHGALALLVLLQFYDGPTQFSDLILPGTEEDLIQQGKYDINTADDTEITLTATITGGSGHSKKVHTLPKNPRRRMHKLLLAARGYYPHSALWMLQQGRMEASQCHLEKAVDIMDADIGPIEMKQVEALMLFDKTMFMLFLNRYEQSATNFIRLIDINAWSHAWYTYVAATCSIEIYRENLRAGNAEAAKKAKDTATRLLTEAPGLIGKKKLMAKTMPMDVFLSRKISQMQQLSKQHNIDLVDAAGVSPVQEVVYFWNGYGKMPEYALEKVFSEVLAYSAAPLAPSHIPEQDNEKTVRHLLQAVALRNMGKVEEGYKILNDNVISQIITESNNKYHYNKTVTHKDPWMPPSALYERAMFEWVMHGPKGTETVREWLHLAEKWSDDYELSTRVGMKIKSAFERLDGGALA", "function": "Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.", "AFDB_id": "AF-Q6BZZ6-F1-model_v4" }, { "swissprot_id": "Q17GZ9", "sequence": "MSLFDIEDIKVKPDIVCTYPDPTVPPDAAIVIDNGSYHCRAGWAGKDVPSLVFKNVLAKPRKDRSKKDTSEVVVPTVQIGNDITNIEAVRFQLRTQFDRNVVTHLHVQEQIFDYLFGRLGINADGCVPHPVLLTECVANPNYSRMLMSELMFECYGIPGIVYAVDGLLSYRMNGGQDSGLIVSCGYQATHVIPVLNGRMVEDKVRRINLGGFNMINFMFRLLQLKYPVHVNAITLSRAETMIHNYCSFAYDYTESLRNWALLEFYEQNVIKIQLPYNQNVSAPTLTAEQRLEKRKELSRRLAEINLRKREEKLAEDKVLLTRMLAAEDTLDDEDNVGFTLHEFSVKNVDEYRKMIVTLRERIAKTTQKMNSQQTNNQPEEKPLQLLQPPPNMTIEEWVIETRRKRDEILDKKQIRKQRKQDLAKRRTAAAQERMRIISHLAKKEKGVDDFGMRDEDWDVYKSISREGDSDSDAENEKLIECEEILKQHDSTFVEPVVAPGNIAEFHQLHIGVERIRVPEILFQPSMIGVQEAGLTGTIDYVLKLFPKEDQVKLVGNVMLTGGCANIRGFKERLSRELQAILPFQSVYNLMVAGSPSLDAWRGASQFANSQEFKQSLITRQLYDECGGEYFKEHTASNFYYPTPSQVSSALNDTFN", "function": "Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.", "AFDB_id": "AF-Q17GZ9-F1-model_v4" }, { "swissprot_id": "Q03144", "sequence": "MHKTHSTMSGKSMKVIGVLALQGAFLEHTNHLKRCLAENDYGIKIEIKTVKTPEDLAQCDALIIPGGESTSMSLIAQRTGLYPCLYEFVHNPEKVVWGTCAGLIFLSAQLENESALVKTLGVLKVDVRRNAFGRQAQSFTQKCDFSNFIPGCDNFPATFIRAPVIERILDPIAVKSLYELPVNGKDVVVAATQNHNILVTSFHPELADSDTRFHDWFIRQFVSN", "function": "Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform.", "AFDB_id": "AF-Q03144-F1-model_v4" }, { "swissprot_id": "Q9LSF1", "sequence": "MLEGDEKQSRALDFNRLEVLSLLGRGAKGVVFLVRDDDAKLLALKVILKEAIEKKKKGRESEDDEYKRVSFEQGVLSRFDHPLFPSLHGVLATDKVIGYAIDYCPGQNLNSLRKMQSESMFSDEIIRFYAAELVLALDYLHNQGIVYRDLKPDNVMIQENGHLMLIDFDLSTNLAPRTPQPSPSLSKPSPTMKRKKRLFRFTSFCNSGISPQESISVHSSSTLAVSDSSGEKSNSFVGTEEYVAPEVISGDGHDFAVDWWSLGVVLYEMLYGATPFRGSNRKETFYRILSKPPNLTGETTSLRDLIRRLLEKDPSRRINVEEIKGHDFFRGVDWEKVILVSRPPYIPAPDDGGDKGTDVNTKMDVENIVQEIFAARQEREKQSGDNNKNANMKIKDNTSGEWVKGLNNNHDLESDNNFLVF", "function": "Involved in oxidative burst-mediated signaling. Required for basal resistance to P.parasitica infection and root hair growth. Partly required for the activation of MPK3 and MPK6 by hydrogen peroxide and cellulase elicitor.", "AFDB_id": "AF-Q9LSF1-F1-model_v4" }, { "swissprot_id": "P19516", "sequence": "MIRICPIVRSKVPLLGTFLRSDSWLAPHALALRRAICKNVALRSYSVNSEQPKHTFDISKLTRNEIQQLRELKRARERKFKDRTVAFYFSSVAVLFLGLAYAAVPLYRAICARTGFGGIPITDRRKFTDDKLIPVDTEKRIRISFTSEVSQILPWKFVPQQREVYVLPGETALAFYKAKNYSDKDIIGMATYSIAPGEAAQYFNKIQCFCFEEQKLAAGEEIDMPVFFFIDPDFASDPAMRNIDDIILHYTFFRAHYGDGTAVSDSKKEPEMNADEKAASLANAAILSPEVIDTRKDNSN", "function": "Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.", "AFDB_id": "AF-P19516-F1-model_v4" }, { "swissprot_id": "Q28I03", "sequence": "MSEKPAFVSVQQSLRKSFDAIEPLHEEWNNTLLECNPHLTSLSNLAEQLQACQRVLFKKTPLSSFINLQEHLRFKLQAAMEFNLEILNQKLSTLQRIRDSVSQVVGSVLYMYETSIEKIGLEAILERSSLCPSIADMLEWLQDIEKHYRNQYLQRKLLLQVCGGHLSDIQALPQSWAKQRDAASSKQQHVEDILLSVSFFRMST", "function": "Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles.", "AFDB_id": "AF-Q28I03-F1-model_v4" }, { "swissprot_id": "Q01610", "sequence": "MIKRNLNDLLSFVAVAREGTFTRAAAQLGVTQSALSQSISGLEARLQIRLLTRTTRSVSPTAAGERLLNAIGNRFDEIEAELDELSALRDKPSGTVRITCGDHIQRTLLLPRLTPLLLEYPDIKVEFDINYGFRDIVADRFDAGVRLGDTIDKDMIAVPIGPPVRMAVVAAPAYFAAHPKPRSPRDLVDHNCINMRMQSGGGLYAWDFQRKDRHVNVRVDGQLIFNTSPNIVDAALAGLGIAWLPEEEFAPHIEEGRLLRVLENWCPLFPGYYLYYPNRRQPSPAFSLVVDALRYTRPRGTTIGGG", "function": "May have a role in the regulation of oprD expression.", "AFDB_id": "AF-Q01610-F1-model_v4" }, { "swissprot_id": "Q7WSH3", "sequence": "MSKPNQNAMPESSLTLPGMLADVVSRFAGRAAIVENGKSISYAQLQQLSRLAARALMSLGVQAGDRVALWAPNLSEWIVAACGVHAAGGVLVPLNTRMKGAEAADILERSRARVLVCVGDFLNNYYPDLLNGLRPVTLQQVVVLGDKVLPSADMNWAQFMARADGTTAEAQQQREARIKPDDTADLMFTSGTTGRPKGVMCAHRPTILAFKAWSDVVGLTEGSRYLIVNPFFHTFGYKAGWVAALLQGSTVYPEQIFDAQAILHRIESDRISFLPGPPTLFLSMLAHPGLKNFDLSSLKSSVTGASTVPPILIKRMREELGIMNVTTAYGLTECGGCATLCEPSDNVETVANTCGKALPGTEVRCVDEQGRPVGPGEAGEVLLRGYHIMQGYFEDEKATEETIDADGWLHTGDVGVLDERGYLRITDRLKDMFIVGGFNCYPAEIERMLSNHPEVAQVAVVGVADERMGEVGCACVVTRNGVTLDQEAFIAWCRANMANYKVPRFVLQLDGLPVNASNKVQKRDLLQIVKDRLASVPQPA", "function": "Involved in the catabolism of the rings C and D of cholesterol. Catalyzes the ATP-dependent CoA thioesterification of 3aalpha-H-4alpha(3'-propanoate)-7abeta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA.", "AFDB_id": "AF-Q7WSH3-F1-model_v4" }, { "swissprot_id": "A0QXE5", "sequence": "MALRVVVGADDAGYEYKEALKGDLAADDRVTEVIDVGVGADEDTAYPHVAVAAARLIAEGKADRALLVCGTGLGVAISANKVPGIRAVTAHDSFSVERSVLSNNAQVLCFGQRVVGLELARRLAREWLGYEFDPTSKSAEKVQAICGYEPATS", "function": "Catalyzes the isomerization of D-erythrulose-4P to D-erythrose-4P. Involved in the degradation pathways of erythritol and D-threitol, that allow M.smegmatis to grow on these compounds as the sole carbon source.", "AFDB_id": "AF-A0QXE5-F1-model_v4" }, { "swissprot_id": "Q06648", "sequence": "MTSASITNTGNETMNLPQMRSIWLDEDEEAEKLYGLQAQQFMGSDDEENLGITFINSDKPVLSNKKNIELPPLSPNSHPSCHHRRSNSNSAKSKESSSSSSSANKTNHKKVFLKLNLLKKKLLGAQPDIRGKGISTPFDFQHISHADTRNGFQDEQLQEPSSLSTEIKDDYTSSSSKRDSKSLNKAFVTERIPANRESKLISRSHENKTSRLSVARSISVTSSNYSKNTQGNNHSINGRVVSTSTMATSIFEYSPNASPKQFKNKSHALGHRYTNSTDSSESSLDFLKNYNFPTLLEDKPILDFLPRSQRSSAYRSLLETPNSNKDSAKAFFPSRQSPLPKRRNSIATPSPQSKFSYSDSPVNHRKSFDDVLYSFNQLEPLQT", "function": "Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone.", "AFDB_id": "AF-Q06648-F1-model_v4" }, { "swissprot_id": "P60928", "sequence": "MSTLNYLLIFILAYLIGSFPTGVLVGKIFFHEDIRNFGSGNIGTTNSFRVMGPVAGSAVLVIDVLKGTLATDLPLIFHLKGPKYLLLIAGACAILGHTFSIFLKFKGGKAVATSAGVFLGYNLKFFGLCALVFLPMLFITSYVSLSSLVSIVIIFICSFWFHDIFLTIITGIMMILLFVRHRSNIKRLINHEENIVPFGLWYWYKKSHGLLKKNAKNK", "function": "Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.", "AFDB_id": "AF-P60928-F1-model_v4" }, { "swissprot_id": "Q9UT51", "sequence": "MVANMEFQGTLPFHPLEDPETLLLKFTDFVHQHSVEQCNQLSMYIIASVNSLAEAFYGSHPEKYNIVFQSVEYAAHSPAISVMHVCYLKELLRQGQYATSLKSFNDLEVSKHIPGSILLQYCMYAAYHCLGNNDLDSAKVWYFSILYIPTTTLTSFHEEAYYSFLLLYIITTGKKFQLDSATSSNVLPLKRHMVPYEEFLDAYLKDVNTLRTVIKEHWSRFLKDNSTAFILFALEVYPMHRLKKWRKTFSSLKLEYIAKQLAISQDVAKEIIQKFDNKTNFTVANGEIFLTFNALDDVSPEMHSDLCQQLIEASKNFEASIRLKSVIYSKIMAKKLNA", "function": "Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.", "AFDB_id": "AF-Q9UT51-F1-model_v4" }, { "swissprot_id": "Q4P384", "sequence": "MNAPLTLHRSGAGPSSYSSHRPLITQQRLVGASSSIPSQFIHNEFSFEQYIKDHLNVKLDNDAQICPDYSERLQCPRGASCPRRHVRPSHLNFLPAGSTALRDPNKRTVCKHWLRGLCKKDDQCDYLHEYDMRRIPECRFYATFGFCNSGDDCLYLHVDPAIKRRECERYNRGFCPKGPLCTKKHVRRVACPLYLAGFCPEGLDCPRGHVKSTPASSASRSNSPIQTHRPLTAAEAFGTGTGRGDEYGDGAGMRNQRAPAGRYGLPSGGAAGGAGAADIGASRGGMGYANNMQRRPNNVFGAPAQGAQEGGRGWRKDLSEVLCFKCGEMGHFANMCPNPALPGNRGGVERGPGGQARQARDRPRPY", "function": "Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.", "AFDB_id": "AF-Q4P384-F1-model_v4" }, { "swissprot_id": "P0C1J6", "sequence": "MSVQGFWGLQLVPGKTYSQVVSAPFRITMASLAADAEAGKRTSVSVLVDEKEFVLCTLVPNKIEQQPLDITFVEGEEVTFSAKGQNNIHLTGNYVFQDDEDDEMGASMIDSDEEDNVEDFLKKLPPNASKEDINKALLGLEVDEEIESDEEVESDEEIESDEEIESEEEEEEPVPVSKKRPAEEVKEIASKKQKAEKKEQPKKEKSKKEEPKKEEPKKEQPKKEEPKKKEEPKKKEEPKKKEEPKKKEEPKKKEEPKKKEEPKKKEEPKKKITKLPNGLIIEDIKMGEGASCKNGQRVGMRYIGKLTNGKVFDKNVSGKPFSFLLGRGEVIKGWDLGIAGMKAGGERKLTIPAPLAYGKRGAPPDIPKNATLVFDVKLLSMK", "function": "PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.", "AFDB_id": "AF-P0C1J6-F1-model_v4" }, { "swissprot_id": "P49762", "sequence": "MVAANLEVPTSSSSSAATKRQKDVDNKLEKCLNDMLKLKTSSNNNSTSNSNNNAIMSHSLTGEHKDPKTALEGPTSSSSSSSSKYIGESQIPVPVQLYDPQKPLLQQQQQQQRICYPIGKSNSTSQLPMGGYQRLLQHQQQQHHQQQQQQHQEQQQYPQHKRPFLNWNSFACSAMNGASDPFMQQQHMPAHQQQQHLPHKLQQSYSSSHVPKQAPKSGLAMFLQKNTNKENKFGQPMQQQPPGMMPQMYGYQAPQQQSKIGYPRTGAPLTHSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPHHRVGEVSNKQPLSSGSSSRERSHSLSR", "function": "Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins.", "AFDB_id": "AF-P49762-F1-model_v4" }, { "swissprot_id": "P41000", "sequence": "MTKKNAFKNSEDMKKYHLSEFNSEATSLTRPSPKSLQHVPCKFFRQGTCTSGKNCIFSHDLELATEKTICKYFQKGNCKFGSKCALEHVLPDGRKVKTRAFAPSTTAMGSSSQNISAAPMANIISNNDKILPMTTMASATASEEKNRIKDEALVIKKEESNVAIPSEVTVAANAFSASTEDVYSIVGDSLSKKASVKDFSDVTGIETIPAYVEATNGSSTVRSPHAKRSLSSISVKSSTSPFSGSKFLSSSSYPHTPEAHLNSNHISPASFGSGIRTRNIFNPESMSLGLKPPILNRSYSASMAPGFSMNTFTATGNLGRPTKSPSVPTSVGSNKSRKFPGINGSTLTATPSSLENLYPLSSRRSVPNLISSLGTSPSTFSSQFLKSTDRTHSFTSKLQSFNPVGTSLLASSLGTSQEDSVNYDIPDEFANEEDFIPNSLQELLTPEELERKMSHGDEAVSSSSASRFMSKVSSNLNSGNPTPYNSYNGTPTSSRFVAFFDRHRQESEKATPPSLNKVSQEPLTATTPKNLGNLTAISETLENGQTLKSNMASSIEKSKTSTEVVASYDTTLDEETQFQMDEA", "function": "Responsible for supersensitivity to the spindle poison, isopropyl N-3-chlorophenyl carbamate. Has a role in meiosis.", "AFDB_id": "AF-P41000-F1-model_v4" }, { "swissprot_id": "Q5JFW4", "sequence": "MISSEEKVEFLRKLVEIYSPTGRESEAVKFIVESFESFGVDAYVDEVGNAIAIREGKGPRILLAGHVDTVPGIIPVRIEDGVLWGRGSVDAKGPLATFFFATLESNANIIFAGLVDEEGFSKGAKNLDVPRPDYIIIGEPSGVDGVTIGYKGSLTAKFVESVEKVHGSLGVDAAERLINRWLEIKSSFGEGFDALSGRIVELHAYERDFDFYGEMVINLRTPPGYNPPKGWEILDFVPAYQVDRRSPLVRAFVRGIRRNGMRPRLKKKTGTADMNILGPRFGVDAVAYGPGDSRLDHTPHERISLSEYLLAIDVLVDVIEELKGAKERAAEESGEREAGKALSG", "function": "Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.", "AFDB_id": "AF-Q5JFW4-F1-model_v4" }, { "swissprot_id": "Q9P0W0", "sequence": "MSTKPDMIQKCLWLEILMGIFIAGTLSLDCNLLNVHLRRVTWQNLRHLSSMSNSFPVECLRENIAFELPQEFLQYTQPMKRDIKKAFYEMSLQAFNIFSQHTFKYWKERHLKQIQIGLDQQAEYLNQCLEEDKNENEDMKEMKENEMKPSEARVPQLSSLELRRYFHRIDNFLKEKKYSDCAWEIVRVEIRRCLYYFYKFTALFRRK", "function": "May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.", "AFDB_id": "AF-Q9P0W0-F1-model_v4" }, { "swissprot_id": "B9TQX1", "sequence": "MNWNQIIFISLIATVLILAIANEAESAAVRTDKSDIKREDGENMKKRIFMQESEATAFLKRRGRRSTKSKDEVNAENRQRLAADERRREYYEEQRNEFENYVEEERDEQQERNREKTEQWREYHYDGLYPSYQYNRHHI", "function": "May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.", "AFDB_id": "AF-B9TQX1-F1-model_v4" }, { "swissprot_id": "O14174", "sequence": "MERNNGLGDYTYRYHGKELSLDDFQNKQGIESSDDAFLSKIYENVSNFNVPRKLHDIEHKFSKEEPSLILHIHKFHFRFEQQDGAFTYNGPVKSILQYIRMELIPPDCLEVFRNSDVKFYDGCLTVRIIDHRQSPSADQTVQPQPGSTNQQQQNNTNPINNQPEDTKPNTNSPPVYHTVLRPTPETLWQDLCLLSESFANSLSDEAVLTLESNILLASEAPLFLTPAKSKAEMIQFMNQLADSAPPCTRKKPQGSAQLADEEAERLEKENLLLLMDDQRKRDFQPTFQRLQFIENVRRKRAILQQRQMQMQQQQKAQQQQSPKAQQPPAHLVQSAPVQRKTTPKIQRLPPSSIQIPPPKPMQKFPANAASSESPPNATGNFLPSGPVPANEPMLKRESVDLIKIRQLAILFQQRASQLKARGATREQITEILNRQAIAAGTDLATVMTVARNLHFQQLQMRQQQQQQQMKAER", "function": "Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs).", "AFDB_id": "AF-O14174-F1-model_v4" }, { "swissprot_id": "P14090", "sequence": "MVSRRSSQARGALTAVVATLALALAGSGTALAASPIGEGTFDDGPEGWVAYGTDGPLDTSTGALCVAVPAGSAQYGVGVVLNGVAIEEGTTYTLRYTATASTDVTVRALVGQNGAPYGTVLDTSPALTSEPRQVTETFTASATYPATPAADDPEGQIAFQLGGFSADAWTFCLDDVALDSEVELLPHTSFAESLGPWSLYGTSEPVFADGRMCVDLPGGQGNPWDAGLVYNGVPVGEGESYVLSFTASATPDMPVRVLVGEGGGAYRTAFEQGSAPLTGEPATREYAFTSNLTFPPDGDAPGQVAFHLGKAGAYEFCISQVSLTTSATPPPGYEPDTGPRVRVNQVGYLPFGPKRATLVTDAAEPVAWELRDADGVVVADGTSEPRGVEPSAAQAVHVLDFSDVTTQGAGYTLVADGETSRPFDIDGDLYQQLRYDALNYFYLARSGTEIEADVVGEEYAREAGHVGVAPNQGDTDVPCIGPRDYYDGWTCDYRLDVSGGWYDAGDHGKYVVNGGIAVGQLLQTYERALHAGTADALADGTLDVPEHGNDVPDVLDEARWELEWMLSMIVPEGEYAGMVHHKVHDEGWTGLPLLPADDPQARSLHRPSTAATLNLSAVAAQGARLLEPYDPQLAQTLLEAARTTWAAAQEHPALYAPGEAGADGGGAYNDSQVADEFYWAAAELYLTTGEDAFATAVTTSPLHTADVFTADGFGWGSVAALGRLDLATVPNELPGLDAVQSSVVEGAQEYLAAQAGQGFGSLYSPPGGEYVWGSSSQVANNLVVVATAYDLTGDERFRAATLEGLDYLFGRNALNQSYVTGWGEVASHQQHSRWFAHQLDPSLPSPPPGSLAGGPNSQAATWDPTTKAAFPDGCAPSACYVDEIQAWSTNELTVNWNSALSWVASWVADQGSAEPVPTAPVVTRQPVDATVALGADATFTAEASGVPAPTVRWQVRAGRGWKDVAGATGTTLTVRATARTDGTRYRAVFTNAAGSVESAVVRLTVERAAPVVTQHPADVRARVGTRAVFRAAADGYPTPCVVWQVRWGGGSWRPIPWATSTTLSVPVTVLAAGTEYRAVFTNAVGTAATEPAELAVQRPRS", "function": "The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.", "AFDB_id": "AF-P14090-F1-model_v4" }, { "swissprot_id": "Q01252", "sequence": "MMENYITSFQLRFCPAAYLHLEQLPSLWRSILPYLPQWRDSAHLNAALLDEFSLDTDYEEPHGLGALPLQPQSQLELLLCRLGLVLHGEAIRRCVLASPLQQLLTLVNQETLRQIIVQHELLIGPWPTNWQRPLPTEIESRTMIQSGLAFWLAAMEPQPQAWCKRLSLRLPLATPSEPWLVAESQRPLAQTLCHKLVKQVMPTCSHLFK", "function": "Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.", "AFDB_id": "AF-Q01252-F1-model_v4" }, { "swissprot_id": "P13423", "sequence": "MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG", "function": "Mature form that oligomerizes and forms a pore to translocate the enzymatic toxin components edema factor (EF) and lethal factor (LF) into the host cytosol. Following attachment to host cell receptors and cleavage by FURIN, homooligomerizes to form ring-shaped oligomers that are in a pre-pore conformation, and associates with EF and LF. Toxin-leaded complexes are then endocytosed in a clathrin-dependent process, followed by a conformational change of oligomerized PA-63 from the pre-pore to pore state, which is triggered by the low pH in the endosome. Once active, the pore mediates unfolding of EF and LF, which pass through the pore and translocate into the host cytosol.", "AFDB_id": "AF-P13423-F1-model_v4" }, { "swissprot_id": "Q9VFX3", "sequence": "MAANQKIVFALVCLFLACDLVLGQQQAANSSDSDSDVAESRTFGHHFLRRISFALVPGAFVVGVITTLLAALTVVSIKGLGVGVILLVLAIGQMLSRALPVQAAAAYAAAPVPVQAPVPVVYSHSHTQQPVWLEKEW", "function": "Transmembrane protein that plays a key role in trachea development by regulating crb localization and maintenance at the apical cell membrane. Required for anisotropic apical surface expansion important for tracheal tube elongation and lumen stability at larval stages.", "AFDB_id": "AF-Q9VFX3-F1-model_v4" }, { "swissprot_id": "Q9X600", "sequence": "MGNMGTSELLKHIYDINLSYLLLAQRLINDEKAFCKVFVGGIQGKGGAGYLDATGLLPQMVKLAETNQLICHFRFRRITITIQSLDSGNQRVDDLQQIHTGILLSSNLLQQLTSKEENLPKKRA", "function": "Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.", "AFDB_id": "AF-Q9X600-F1-model_v4" }, { "swissprot_id": "Q6FP72", "sequence": "MSSNNQNTNNTSIELISENGPISLNLMMEEGVKALTRILSNQLNDTPGTQPMHFIIKKNDKDNKAIDINGDDEEVVELGNESNYHMSDGVQNEAEIILNDQLNDILKNHESQLRLDGEEAEIIFDYETQGTVDGSDSIGEKITQMIESVLPNGLGPNTTGKLQAVLNGKELNITEEIHKSDRIEEEEHIEGGLTTAEGNFEVEFETEPLPEDHKHTEENIDGHENYNDCCPHHHNNQDNRRRAPKYKNYNYHDYEYTVQHPKTEPNFSALINQKKPVCLFCEYYMVFGEPPKNMIKWYNMHYGYNHLPQRNDRHHRNR", "function": "Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis.", "AFDB_id": "AF-Q6FP72-F1-model_v4" }, { "swissprot_id": "B1AKI9", "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGAADGPDAAAGNASQAQLQNNLNVGSDTTSETSFSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERWMSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY", "function": "Acts as an angiogenesis inhibitor.", "AFDB_id": "AF-B1AKI9-F1-model_v4" }, { "swissprot_id": "B2KD65", "sequence": "MAVRRIVKYGEDILRQKLKPVDFKTLEPQLDAILQDMHDTCMSFQGAGLSANQIGLTHRIAMIFIPEKTPKGEAQKFKRYVVINPVIVSKKGCVTDEEGCLSLPGLWVEIERAESIVVHCLNEKGLPVEIHAKGFLAKALQHEIDHLDGKIFIDHADPKLKPEIKKELKKLSKNWS", "function": "Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.", "AFDB_id": "AF-B2KD65-F1-model_v4" }, { "swissprot_id": "Q93WC9", "sequence": "MIMKISMAMCKQPLPPSPTLDFPPARFGPNMLTLNPYGPKDKVVVIMGATGTGKSRLSVDIATRFRAEIINSDKIQVHQGLDIVTNKITSEESCGVPHHLLGVLPPEADLTAANYCHMANLSIESVLNRGKLPIIVGGSNSYVEALVDDKENKFRSRYDCCFLWVDVALPVLHGFVSERVDKMVESGMVEEVREFFDFSNSDYSRGIKKAIGFPEFDRFFRNEQFLNVEDREELLSKVLEEIKRNTFELACRQREKIERLRKVKKWSIQRVDATPVFTKRRSKMDANVAWERLVAGPSTDTVSRFLLDIASRRPLVEASTAVAAAMERELSRCLVA", "function": "Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP.", "AFDB_id": "AF-Q93WC9-F1-model_v4" }, { "swissprot_id": "P28000", "sequence": "MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKGLKDLMDLCDVVESKFTEKIKSM", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.", "AFDB_id": "AF-P28000-F1-model_v4" }, { "swissprot_id": "P45439", "sequence": "MARAPRSPHPARSRETSRAHPPYGTRADRAPGRGRDRDRSPDSPGNTSSRDGGRSPDRARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFGGPHHAHVRISGGDFLAAPVPREPFALAGNIPYSRTAGIVDWALRARTLTSATFVTQLEYARKRTGDYGRWSLLTVRTWPRHEWRLLGRVSRREFRPVPRVDSGILRIERRERPLLPSAALGDYHRMVELGFSGVGGSLYASLRRAHRAGPLDAAFRAARLDRSVVVAYVTPEQWLTVFRTLRPVRSRPAGR", "function": "This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.", "AFDB_id": "AF-P45439-F1-model_v4" }, { "swissprot_id": "Q0AUD0", "sequence": "MLNKSVARRYAEAFFSIARETGKVDELQQELEKLVSIIETTENLPEYFAHLLIPAKAKKEVANKLFGGQVSQLTLNFLNMIIDKRRETYIGLISEEYRDMADELRNITKAELTAAAPVSEADMKNLEQNLSAKTGKTVQLSLKVDPGLIGGLKIRIGDQIVDATVAKKLEMLKEQLKQAKIS", "function": "This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.", "AFDB_id": "AF-Q0AUD0-F1-model_v4" }, { "swissprot_id": "Q9W0G6", "sequence": "METNVDFSSISSKLYRKYAQHVRNLKDVCVSKTVMKPGAFFDSLQQMMEEEAAATTPPRDLSSVADYAELFKTLEEYPANLQKMPKKRELQRTNSTLLRGADESVAMGINTSNVSLSLTRLEEQRSAVDVYNDFKGFQRKLAKIYDEAAALDTTESIYKQKLTQLHGFAQQLEKLMPTGGESPPDAFTSEQQEKLLTIAANMEQLNYLRSNSLQLPNPNEILATGSLAARLEMFVEVLTYTLLQVSSYNMAMI", "function": "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules.", "AFDB_id": "AF-Q9W0G6-F1-model_v4" }, { "swissprot_id": "B0TEI6", "sequence": "MSRRQGRETALQTLFMADVGRMEPAYALQYASEEFGISEAAAAFARELVEGAVANRETIDGNIRRLAKEWNLERMPHVDRNLLRVAIFEMLFREDIPLNAAINEAIELAKIYANEESAKFVNGILGQLARELREARGEKTSAQEGAPAAVTNRVTTPAPESTPVPDPDATPATTPVTTTVISETAANRETRSMAEEETQPPGVNEV", "function": "Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.", "AFDB_id": "AF-B0TEI6-F1-model_v4" }, { "swissprot_id": "Q5AAL9", "sequence": "MKFLQKFIITVALLTNIVFAIDITENKVDRGSVTLSFGEIIIHPGASWSIIDNAFSNFIGKLDVKAKSALYISSTSHLLALQVSLTTLLHSINNSGIISFDSRVSLTPSSYDLRGLSFTNSGEMYFAASGRVPSTMSLTSASWTNTGLLSFYQNQRTSGAVCLGFPLGSITNSGKICLNNQVYQQTTQIKGSGCFSANGDSTIYIANVLLSVSANQNFHLVDKDSSMIVQAISTTQTFNVYGFGNGNKIGLTLPLIGIILESAHSYDSSTGILTLRNFLLEQRFNIGLGYDSSKFSVVTDSGSGIPSTIWGSVTYTGRVPTRALPKSCQMACKPIPEAPGVKPTDYTTTITKTNTAGNTVTETGAVTISTDKSGSWFTTTSIFPTLTTATSTSITTTLSNEAHIKTTDNTLAKVSSTVDYISAPISSSEFISLESFVDETLSNENPISTSTDYASENSFAISESTFITASDFQATESLVTESYFSKSQSSDSESFVINTSSAVDNSYVSSSSSAGGSSFPEETHMLQTSDSDLSSTAGSESDVTEFSDVSLATASDSSIADKSIGTESLYSEISLVSASESTGSIGELSISGDTLLKTASETKFVKSSFSSDLISETSSELFVSSSVSTDMILETANDSFITSDKVVETPSYSNELAFETVSETIINSFVSSESSLNTASNSLIASKPSTDSSSYTTDIDFETTTKSFAESPSYFSETVSEIASKSSLSMVEPSCWSELPFETSIESLIAPSYISSEPAPETASESFIVKPSYSEIASESITKSIISTIEASISSDIFSDATTGSIVVQPSVSSGISLEIPSESMLFSESSISKPFISSQSIHECTSDSILVVPSFFSSDVSFETVEYSSTVSTSVDAEPSYSSEISLKTPSESFIVSETFLEPSYSGEVVLATPSESVVASETDVNKPSYSNEAVLQTPSESYILSETGVKESSESSEFALSTPSTSFIASETFTVQSFASSEVSFGSDRESTISTEAIQVEPSISNDVVLETASESFISKAPTTSEFTILSETSIVEPSILSDLRFETTSQSTEMAPSATGVSYFSSTETPLASSSSYESSFATSSVSAIQSINSQVASASFVSADSTDSSEVGSSYTTASAFGPASSASEEKFISVWETSNSGGSFTLESSTSVASVVTTPLPFTSNDIITEISSTWNGAKSDSPHTSESDITSQYNSHSTSVATRSDSISLTDTFEIGFASTWTTGGSGNGGSMKSDVSNQDSYATMLPTSFLDTSNSDITTGVVSTWDAKNSNSYTSAELSTDPYSSDGYASSATAALSITESIPTTDTINTEYHSNGDITTSGGFKEISLTSHYEGGFTSESAGYTIASPSGSTQEFATATITSCFESKCSENVVTYISSVSHSTVTTGYEDTRFTGSIFSGDLASTGDNIVSASGRSVTDATNPFATNTDIGTTSTVSLYGDLNDSDSSVSGYPTNRSDSNGYANTPTTGSNTSGDFSQTIETGSSSFTAIPFENGSTNISNKYLKFLGTVVSILILLI", "function": "GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence. Plays a role in adherence to plastic and to host epithelial cells. Promotes the tissue fungal burden during murine vaginal candidiasis. Increases also susceptibility to neutrophil-mediated killing. Furthermore, contributes to the severity of hematogenously disseminated candidiasis in normal mice, but not in neutropenic mice.", "AFDB_id": "AF-Q5AAL9-F1-model_v4" }, { "swissprot_id": "Q9C5Y0", "sequence": "MAEKVSEDVMLLHGDLDLKIVKARRLPNMDMFSEHLRRLFTACNACARPTDTDDVDPRDKGEFGDKNIRSHRKVITSDPYVTVVVPQATLARTRVLKNSQEPLWDEKFNISIAHPFAYLEFQVKDDDVFGAQIIGTAKIPVRDIASGERISGWFPVLGASGKPPKAETAIFIDMKFTPFDQIHSYRCGIAGDPERRGVRRTYFPVRKGSQVRLYQDAHVMDGTLPAIGLDNGKVYEHGKCWEDICYAISEAHHMIYIVGWSIFHKIKLVRETKVPRDKDMTLGELLKYKSQEGVRVLLLVWDDKTSHDKFGIKTPGVMGTHDEETRKFFKHSSVICVLSPRYASSKLGLFKQQASPSSSIYIMTVVGTLFTHHQKCVLVDTQAVGNNRKVTAFIGGLDLCDGRYDTPEHRILHDLDTVFKDDFHNPTFPAGTKAPRQPWHDLHCRIDGPAAYDVLINFEQRWRKATRWKEFSLRLKGKTHWQDDALIRIGRISWILSPVFKFLKDGTSIIPEDDPCVWVSKEDDPENWHVQIFRSIDSGSVKGFPKYEDEAEAQHLECAKRLVVDKSIQTAYIQTIRSAQHFIYIENQYFLGSSYAWPSYRDAGADNLIPMELALKIVSKIRAKERFAVYVVIPLWPEGDPKSGPVQEILYWQSQTMQMMYDVIAKELKAVQSDAHPLDYLNFYCLGKREQLPDDMPATNGSVVSDSYNFQRFMIYVHAKGMIVDDEYVLMGSANINQRSMAGTKDTEIAMGAYQPNHTWAHKGRHPRGQVYGYRMSLWAEHLGKTGDEFVEPSDLECLKKVNTISEENWKRFIDPKFSELQGHLIKYPLQVDVDGKVSPLPDYETFPDVGGKIIGAHSMALPDTLTT", "function": "Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). May be involved in PA accumulation in the dehydration stress response and in the transduction of hormonal and environmental signals to the microtubules cytoskeleton. Prefers phosphatidylethanolamine to phosphatidylcholine as substrate. Involved in H(2)O(2) and abscisic acid (ABA)-induced stomatal closure. Involved in nitric oxide (NO) signaling during stomatal closure. Plays a positive role in ABA-promoted senescence. Involved in basal defense and nonhost resistance.", "AFDB_id": "AF-Q9C5Y0-F1-model_v4" }, { "swissprot_id": "P53628", "sequence": "MSKVMKPSNGKGSRKSSKAATPDTKNFFHAKKKDPVNQDKANNASQITPTVPHSHPSDMVIPDHLAELIPELYSFQQLVDSEKRLDHFIHLRNLHMKRMVAQWERSKLSQEFLYPHLNFPNVKFLRIFISNVSENQPWQMDTNNEADLMALENATWTMRIEGRLLDNVQANDPAREKFSSFIESIVVDFKNKENDNVPSTKFNAAPEENATEGPSDKKLNLNLPLQFSLPNGDNSTTTNTDQNNATMGEETAKKDMSSTTPKLESVKWQYDPNNPVDFDGLDIKRVGSENVECTISILRKSSPEEPFMSYSPQLTAIIGLKSGTSHDAIFSIYKYIHLNELLTNDESAFENLMGNRNNHNSNTSTSKMLDAASSQVSIVKLDTQLITLLPSSLKESSPDTMKLTDLLSLINSTHLLPLQPIEIDYTVRVDKASTYGELVLDIEVPDVNALKFNNTQRESQIGAAELNENARELEQIKPKIALQDKEITSVLSNLHESNKRYRFFKKISEDPVKALNECIASTSNALKVLSGDEGYNEDMVRRANFYKENEAMLRENIEVILSNGRM", "function": "Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.", "AFDB_id": "AF-P53628-F1-model_v4" }, { "swissprot_id": "A8QCY3", "sequence": "MSTISATVAGPSIVQFVQIDSLVVMKIVKHVDSEMYAGLNEVAGEACQGLLTGLVSIDDRRLEITNCFPTARAEPMLDGDEIAQNNAFYEEQKQAEMLDMLRKFRDMNIDYELVGFYQAHPFGACFAQETIDSLIDYQASVPDGVVLIYDPVKTRQGQLSIRAYRLSTKALEMSLDGDWSPESTRTAGLTYENMLEELPVVIKNSHLVNVMLAELALEGDCAIQRSSSHLELGTRRSLEKCLRSLMSDVDDLNRTVMAYTKYVADKQRYDLTVYNAMQKRQAENEQREARGEPPLSFDDIKKMKPPQLTTKCGMLESFLCSSDARAHSDYAAEACLRHFSFSSFCLCFFNENIAKLFLAEAVVDSHGSRDHGGAAASVR", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.", "AFDB_id": "AF-A8QCY3-F1-model_v4" }, { "swissprot_id": "Q0VBM2", "sequence": "MEASSMLSSLNDECRSDNYVEPHYKEWYRVAVDTLIEHGLEAYQEFLIKERVSDFLAEEEINYILKNVQKIAQNTEHGSDSSCDDGSSSGTYWPMQSDVEAPNLDLGWPYVMPGLLGSTHIDLLFHPPRAHLLTIKETIRKMIKEARKVVAIVMDVFTDVDIFKEIVEASTRGISVYILLDESNFSHFLTMTEKQGCQIQRLRNIRIRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGHLVELFDEEFRTLYARSSVPSSFAQEESVRAKPGKALWENGIYQRSISSLASVSSQRNLFGRQDQIHKLDSSYFKGRGIYPLNDQDKHSMRNHGYKPHFVPNFNGPSTIRHFQPSQLNENWKRHSYAGEQPETTPYLLLNRAMNRTNNAPGRWRRPSDSLSVASSLRGGQGSQQNIPAQSFADRLAQRKTTNLAERNSNVRRSFNGTDNHIRFIQQRMPTLENTTKSFLRSWRIESYLNDNSEVPPDSNGSTLGDRFEGYENPEAVKANALYTHSRLRSSFVFKPTLPEQKEVNSCTTGSSNSTIIGSQGSDTPNEVPDTSTNAPPLTEKPLPEPSSKLPTQQEEPKMHNLQVPEKQPEALNQRTNGRAELNNCIYTNLCVNKQRENTENQQNDNLLKRRSFPSFDHSKVNLEHGNSKNYVYSTLTRNRIRQPEKPKEVVLKSSKSMHNVTHSAEEDDDEVIERDPPSASATKSISIAALLDVNKEEPNKEPNSKKEGKASPSFLKKGSQKLRSLLSLTPEKRESLAKNKAPAFYRMCSSSDTLVSEGEENQKPKKSEPKVDSSPRRKRSSSSNSQGSIHKSKEDIAVSASPGISSQAEESRRIAPSPRPVERRLSERAGDASAPRFNTEQIQYRDSKEISSLMTPARRPTPSPVLKPNELLRSHSTNQRVYSRFEPFCKIESSIQPASSVTNTHVNRPEVKSSTMGTAYGRSSPMLNYKTGAYHSYAPNENKFRGFMQKFGNFIHKNK", "function": "Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.", "AFDB_id": "AF-Q0VBM2-F1-model_v4" }, { "swissprot_id": "A7TQR2", "sequence": "MFERQSNNPEPIEVSDNNPERESTADALLTTRIYISNLDYSSTEDELIEYLKDYKPLSVLVPSHTVRGFRSNHVKPLGIAYADFETPEKAREAVEALNETNFKNRNLKVKLYVPFSPENVCKPAPKPRRLSKLRRSKKPADEENNAASQDPTVEATQERGQASEDPENAANNAKQAKPTSDDTVYCGYLPKNTTDADLREHFKDYNPQEIWIFRTRAAKGPMHLQLHRHYTAALITLNSPETIAKIAEVTSTKKILGKKISVKPAYISKIQEVKKIAEQTGIAERNQTNKGAIKPNSGNGGQPAGPGVAGEPSNPQQNCDNSNNVQPGVSVVA", "function": "May be involved in the modulation of rDNA transcription.", "AFDB_id": "AF-A7TQR2-F1-model_v4" }, { "swissprot_id": "P48363", "sequence": "MDTLFNSTEKNARGIPQAPFIENVNEIIKDPSDFELCFNKFQERLSKYKFMQESKLATIKQLKTRIPDLENTLKICQSLRNHSDEGDESDEPILLHYQLNDTLYTKAQVDIPEDRADLKVGLWLGADVMLEYPIDEAIELLKKKLADSEQSLTVSTEDVEFLRENITTMEVNCARLYNWDVQRRQDLKQAQEGTKNLKI", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.", "AFDB_id": "AF-P48363-F1-model_v4" }, { "swissprot_id": "A1YFY6", "sequence": "MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSWTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEICHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISSHQTAGDHPTVSPNCFGSHRQYLDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS", "function": "Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.", "AFDB_id": "AF-A1YFY6-F1-model_v4" }, { "swissprot_id": "Q06668", "sequence": "MIVFRRFPTCLLHHIRQPASRSLLLESQRRSLSFTSYKYNSSHIDDDKSKKKLKNVFQMNSNRVIRKQKTKEELAKERFEEQLRSPNRFVRWGAIARSEKFSKGMTKYMIGAYVIFLIYGLFFTKKLFAKDKELERLLKKQEEGNANEYEALRIKELKGKLRRRDELKLEEYKKMQEEGIENFDDIRVQNFDQNKLNEQILPARDTTNFYQEKANEYDKAINMEERVIFLGKRRKWLMKHCQGDVLEVSCGTGRNIKYLDMSRINSITFLDSSENMMEITHKKFREKFPKYKKVAFVVGKAENLVDLAEKGKPSLENEKENQVKYDTIVEAFGLCSHEDPVKALNNFGKLLKPDGRIILLEHGRGQYDFINKILDNRAERRLNTWGCRWNLDLGEVLDDSDLELVEEKRTHLGTTWCIVAKRKGDVKKKDELGFVEKYLQSSIRKRMESFEKKDDMASKKELEPVPPVSKS", "function": "Mitochondrial methyltransferase which suppresses respiratory defects caused by OXA1 mutations when overexpressed.", "AFDB_id": "AF-Q06668-F1-model_v4" }, { "swissprot_id": "P62511", "sequence": "MTSQLAGFKGTRGTLLVGIGGCSSSGKSTIAKLAVQVLEDAVLVHQDDFYRHDDEVPFDEEYQIGNWDVPEALDMAQFERELDHIRATGRPAAKLVHNGNIDDVGKFGISEEYLEELRRRYRGRISQPVVLVDGFMLYHDDKVAARFDCRLLVRAPYATMKARRASRGGYKTLDSFWQDPPFYFDKFVYKSYAATHARLFRNCDVEDRLVAPDVQEIYNGDEAQITCVLEQVLDAIAAAQC", "function": "Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).", "AFDB_id": "AF-P62511-F1-model_v4" }, { "swissprot_id": "Q1RIG5", "sequence": "MDSLENLILVGVIKSCHGIKGHIILRSFTDPTVKITERELVNESGEKVNINLIKQNSKGELICQFNDISTRNEAANLKGYKLFCLRSSLPKLEEDEFYITDLNNLPILDNNHTEIGKIKNILNFGAGDIIEVEFLDKTTELLPFNKDFFPIITKDYAILNYKRDEL", "function": "An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.", "AFDB_id": "AF-Q1RIG5-F1-model_v4" }, { "swissprot_id": "P80964", "sequence": "MAPRLGIFLLWAGVSVFLPLDPVNGDQHLPGRFLTPAITSDDKCVFPFIYKGNLYFDCTLHDSTYYWCSVTTYYMKRWRYCRSTDYARCALPFIFRGKEYDSCIKEGSVFSKYWCPVTPNYDQDRAWRYC", "function": "May form a complex with spermadhesin AQN-1 which possesses phosphorylcholine-binding activity.", "AFDB_id": "AF-P80964-F1-model_v4" }, { "swissprot_id": "P23910", "sequence": "MKKVILSLALGTFGLGMAEFGIMGVLTELAHNVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVMASVYFWVPDIRDEAKGNLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYVKPYMMFISGFSETAMTFIMMLVGLGMVLGNMLSGRISGRYSPLRIAAVTDFIIVLALLMLFFCGGMKTTSLIFAFICCAGLFALSAPLQILLLQNAKGGELLGAAGGQIAFNLGSAVGAYCGGMMLTLGLAYNYVALPAALLSFAAMSSLLLYGRYKRQQAADTPVLAKPLG", "function": "May be involved in either the transport or processing of arabinose polymers.", "AFDB_id": "AF-P23910-F1-model_v4" }, { "swissprot_id": "P71650", "sequence": "MMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQAEQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS", "function": "Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE9. Acts as an mRNA interferase, specifically cleaving between U and C in UAC sequences. May cleave its cognate antitoxin's gene. In E.coli expression with non-cognate antitoxins VapB27 and VapB40 partially neutralizes the toxin.", "AFDB_id": "AF-P71650-F1-model_v4" }, { "swissprot_id": "Q9P0M6", "sequence": "MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVGAPVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIASGGVLPRIHPELLAKKRGTKGKSETILSPPPEKRGRKATSGKKGGKKSKAAKPRTSKKSKPKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHPTTAEIDLKEDIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAISAHFDDSSASSLKNVYFLLFDSESIGIYVQEMAKLDAK", "function": "Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.", "AFDB_id": "AF-Q9P0M6-F1-model_v4" }, { "swissprot_id": "Q54EY2", "sequence": "MEKQAEKQLEKQLESFILHLKRKTVVGSYQVSRASAELLRQWVHKGKWGNAKSLIDQIKIIGKKLMNAQPLEFCIGNIVRRVLFIIREEYLTFFRNKKNGLNNDDYDDDDFETTTSNNNNNNNNNNINSSSNINKNNKYSNVMLQDDPIDDQEDIDFTETFPRLKAAIMDSINELIDELEGLHRNVAEQAIEHIHSNETIMTLGCSRTVEEFLKEAARKRSFKVIVVETAPSLEGQKTAISLSKASIDTTLITDSAVFAMMSRVNKVIIGTHAVMANGGLIATSGTHTLAVAAKYHSVPIVVCTGLYKLCPLYAYDQDTFNNFGSPGEYLKFEEAEFLENVHSYNPTFDYVAPDLVSLFITNIGGHNPSYIYRLLQEYYDARDILEDE", "function": "Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.", "AFDB_id": "AF-Q54EY2-F1-model_v4" }, { "swissprot_id": "Q9QY06", "sequence": "MSAHEAGSSGRRQQATYHLHIYPQLSSAGSQTSCRVTATKDSTTSDVIQDVVASLHLDGSKHYVLVEVKESGGEEWVLDASDSPVHRVLLWPRRAQDEHPQEDGYYFLLQERNADGSIQYLPIQLLAQPTAACRLVERGLLPRPQADFDDLCNLPELTEANLLQNLKLRFMQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYAMLRKHVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYLENGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERLEFQLKQPQDYFYLNQHNLNIEDGEDLKHDFERLQQAMEMVGFLPATKKQIFSVLSAILYLGNVTYKKRATGRDEGLEVGPPEVLDTLSQLLKVKRETLVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDMEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFTQHIFKLEQEEYQGEGISWHNIDYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSHTLLAKFKQQHEDNKYFLGTPVLEPAFIIQHFAGRVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAAGISSPATRSHMEELPRGASTPSEKLYRDLHNQIIKSLKGLPWQGEDPRRLLQSLSLLQKPRTSFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPKDVQPCREAIAALLEKLQVDRQNYQIGKTKVFLKETERQTLQEKLHGEVLRRILQLQSWFRMVLERKHFVQMKHAALTIQACWRSYRVRRALERTQAAVYLQAAWRGYLQRQAYHHQRHSIIRLQSLCRGHLQRRSFSQMVSEKQKAEQAREAAGGKLSEGEPGPVAAGEQLSEHPVEDPESLGVEAETWMNKSPDGMSPKKETPSPEMETAAQKTVPAESHEKVSSSREKRESRRQRGLEHVERQNKHIQSCREESSTHREPSRRASLEIGESFPEGTKGPREDGLEAWTETTAPSSSKQAQVVGDPPGSPSPVQRPTTLALDSRVSPMLPSSSLESPKDKDKDESSTKAQDKPESPSGSTQIQRYQHPDTERLATAVEIWRGKKLASAVLSQSLDLSEKHRATGAALTPTEERRISFSTSDISKLSPVKTSAEIDGDFSSKKPSIHKKKSGDPSAGPDAGLSPGSQGDSKSAFKRLFLHKAKDKKPSLEGVEETESNGGQAAQETPARKTLDVPSSQQHRHTTGEKPLKGKKNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIESLFIEATERFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLAAERGEKDTNLVLNVFQSLLDEFTRSYNKTDFERAKSKAQKKKRKQERAVQEHNGHVFASYQVNIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLSAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKMKMEEINHLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVRIKSPRTPVVQDLELGALSEEAAGGDEDREKEILMERIQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESLLEERGVRGAVEGPPAPALPCPISPTLSPLPEAAAPPRGRPTSFVTVRVKTPRRTPIMPMANIKLPPGLPLHLTSWAPALQEAVVPVKRREPPARRQDQVHSVYIAPGADLPSQSTLIALDHDTILPGTKRRYSDPPTYCLPPSSGQANG", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA.", "AFDB_id": "AF-Q9QY06-F1-model_v4" }, { "swissprot_id": "P0CS31", "sequence": "MLRLQSLGSLPAHAEPAWTVSFNPTRSLLASCSTDRTIRLYSYIIPSSSDGLPSQDDSQAVFSLAKVIETDHKRTVRSIAWSPDGRTLASGSFDSTVGVWEEVIPLSDDEEEEDEGAQGVYKPAGVDSDGDGDGGKEKEWECVTTLEGHESECKSVGFSSDGALLASCSRDKSVWVWEVQPDADFECIAVMMEHSQDVKSIAWHPHEEILASASYDSYIHLAYDDPDSDWCIFQKLHPSLPSTPLTIPSTSPSHLIDALVPTEEEKKAEAELQVPPLEEDETVWCLAWSPDGRWLASGGDNGGIRLWQRTGSQPDSAFKEILHTAAHSRSVFSLSWSPPYPSAESAGSTDSTDLGMLASAGEDGKIIIWQITVPPSPSSASQEIDNEQISIRPIAAQKDAHGVNDINSVAWCVREDKKGWGMLSSAGDDGSVKVWRVVRD", "function": "Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.", "AFDB_id": "AF-P0CS31-F1-model_v4" }, { "swissprot_id": "O62203", "sequence": "MPLESGKLINDLRVSELKTELEKRGLSTQGVKVVLTVRLNKALRDEGLDPADHVFEHAVSPMKKSTRRSNEMARAAAAAAAEKVEKGAGDEGNDENVLVEEKEEEEEEEDSHDLQIIEDHELEVPSDEKDDTLVEDEEFEEAEQVEPEPEAVEPVVEEKPEEKLEEKPEEKLEEKPEEKPVEPEVVTVEEPVAEVIEVEKAVAEPVELKEKPEKEPEVVLVEEPVEQLENEPEVVPMEVEEAKKSDEQDGEDEFEEDDSSSDIEIIEPTLQESEPLAEEKVEKKEKKPEEIPHNLEQNEPISMETEEKVEEEVIILNSSINNVSQDDEIVLDYEEDLLEDPLDEPIEQKEPKAAEPTPKQLQKVEASTPQATPSKAASSSAGSGKSMLFGDDVKKTSIWIRGMTPATKASSVKQLASQYGKVIQSKIFNSKAADANGDVKNCFALIQFADVTAMELAMTSLHQKNYQGRVLRVEKVSESHLTSSAEKLAREKHVAEAASTMSTSPAPTPTPEPVVTTTTTTSAAPKRKEPIHAPESSSSEGQRAKRRAIEAPVRSRSRSRGGGGEPRSSRKPITFDREEESNRDSRRTIAAAPPARTSRMARSPLRAPLRAARGSESSRSSTRGGGGGGESLTISSRVDTSGCRGGAIKRSVERSVPNNISTSELRRKHHQIHVTVQQDAPRASYQTEQYARERSSSTTTSSRRRQVSPDRSEQRRHRDEPPPRRAPQEQPSRRRGASPPEPPRRQEGARRSEEPERRRLFDEREQLAHIMAAKDMYAEQQKIRAEKALIAFQMQQLEKKKLEAELQIAQKALLMQQAALGGGGALVVDGGALVAGGGAVGYHHQEHRSSYGGGGSSSNGGSSNRRRQTRRSPSPPQQHHSSSRRQRRDSGGAGRYRQSTSSSNSNRNSNSGGRNLVVTATTTNNTNATNAGRSYGIQSVPDASSYSTNNYQQRSSAASAYDLQITATMPQAGAANSGAAYHQPYGNVYQHNTAAYPVWGGLDAQGHMAMDTNWSQNAATPSTSTSSGGGGGQQWQQQSYGSNQHQHHQNNNSSQPSSSNRRGNDYGNYRGNY", "function": "Involved in pharyngeal muscle development and ensures pharyngeal grinder function during feeding. Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine. Has a role in the determination of life span.", "AFDB_id": "AF-O62203-F1-model_v4" }, { "swissprot_id": "O08358", "sequence": "MIQVAGVNFEDPIVIASGIVPPTKEYMQNVCEKYEPSAITSKTLTYSPLEPHRSPTFVKISDNCYLNAIGLGNPGIQILRDLGEIKCKLIISIGGSNVNEYIDAVSKINDIPVMIELNVSSPNRRGFGESNLTYVEEIVKNVKSIVKKPVFVKLGPWDNIVEIAGRALSAGADGLTLINTLKGMLIDVEDFKPILSYGTGGISGKCIHALAVRVIHDVFKEYEPEIIGVGGVFDWRDAIELISVGAKLVGLGTVLVEKGFDVIREIREGIGTYLEEKGLKVEEIRGIGVKR", "function": "Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.", "AFDB_id": "AF-O08358-F1-model_v4" }, { "swissprot_id": "P9WMG4", "sequence": "MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAAERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFRAAYEPTLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMAVLVSQASRQ", "function": "Negatively regulates the expression of its operon as well as expression of end (endonuclease 4).", "AFDB_id": "AF-P9WMG4-F1-model_v4" }, { "swissprot_id": "Q9FLI3", "sequence": "MTEIYRTISTGRGDDVSPTKCRERRRRRIEMRRQAAVFGEPSSSRNRDRTDMEVYSSFDVPLRKQARRSEIGGLPADIGGFLAPPAASSCQKSEAPVWKGEETEDEPLYGIVSVMGRSRKMEDSVTVKPNLCKPEVNRQRPVHFFAVYDGHGGSQVSTLCSTTMHTFVKEELEQNLEEEEEGSENDVVERKWRGVMKRSFKRMDEMATSTCVCGTSVPLCNCDPREAAISGSTAVTAVLTHDHIIVANTGDSRAVLCRNGMAIPLSNDHKPDRPDERARIEAAGGRVLVVDGARVEGILATSRAIGDRYLKPMVAWEPEVTFMRRESGDECLVLASDGLWDVLSSQLACDIARFCLREETPSSLDLNRMAQEDDNDGEQNPSRSVLAATLLTRLALGRQSSDNISVVVIDLKNSSQ", "function": "Negative regulator of abscisic acid (ABA) responses during seed germination.", "AFDB_id": "AF-Q9FLI3-F1-model_v4" }, { "swissprot_id": "Q54QV5", "sequence": "MSSCSSLSMDDRVKIGYGSIAGASLSIIGSIGTIILIKIRNKKQEKKLLIQRKQQLSINNLNINSGSSSNIITISNSTTSLSSNNLNIQPPSFPSYSPLPTSISLSNNNNNNKNNNQKTKVSHFIINLSIANLLASIFMITIKLMMIHFNDKFIKVLPSTANHSFNALISVCTIGNGVIGFSFISTFFWTLAISMYIYQQFLSSSTINSNNNNNNINNINNNNNNNINNINNSKNNNSINNFNNSNKSNKIIKMLFYFVCWVIPFVLGSILVSGSRLIELNSDLPWCSIDSNIQLISFYFPLIICLLATTFFTILIKYKFSNDKLACSSSSLINLQSKIIQRLILFLIVILVCWVPSLISFFISFFSKNCKQFLWLEIISSTIQSCQGILNFLSYLSIFKKLKLYFKNLKKKFNNNNSNNSNNSNNNNSNNFNGGGIFYSKGKKVNNQNSNNFYFTFSTFDFDNNQIQEK", "function": "Receptor for cAMP.", "AFDB_id": "AF-Q54QV5-F1-model_v4" }, { "swissprot_id": "A0LDW6", "sequence": "MSAEAMHAAASAAPKMDPLHHFMVQKVVPIEIAGIDLSITNSTIWMWLAVAVAFLFMKWSFRGRAEDKLIPTKMQSLAEMTFTFVRQIVDQNIGGAEGRKYFPAIFTLFLLVLFCNLLGLIPGSFTPTSQLVVTATLALSVFFFATGLAIVKHGTGFIGFFVPSGVPPMLLILMVPIEIVSYLSRPVSLSVRLFANMTAGHTVLAIMFFFAATLPLGGLLMPAAFATVFTGFELFIGFIQAYIFTILTCVYINDALHLH", "function": "Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.", "AFDB_id": "AF-A0LDW6-F1-model_v4" }, { "swissprot_id": "Q00630", "sequence": "MQRFLVFTIVAVATAAAGDIFYPGYCPDVKPVDDFDLSAFAGAWHEIAKLPLENENQGKCTIAEYKYDGKKASVYNSFVVNGVKEYMEGDLEIAPDAKYTKQGKYVMTFKFGQRVVNLVPWVLATDYKNYAINYNCNYHPDKKAHSIHAWILSKSKVLEGNTKEVVDNVLKTFSHLIDASKFISNDFSEAACQYSTTYSLTGPDRH", "function": "This protein binds a chromophore: biliverdin IX, isomer gamma. Mixed with lipoprotein-bound carotenes, this blue protein provides hornworms with their green cryptic coloration which serves a camouflage.", "AFDB_id": "AF-Q00630-F1-model_v4" }, { "swissprot_id": "Q65CJ7", "sequence": "MEAIGVLMMCPMSTYLEQELDKRFKLFRYWTQPAQRDFLALQAESIRAVVGNSNAGADAELIDALPKLEIVSSFSVGLDKVDLIKCEEKGVRVTNTPDVLTDDVADLAIGLILAVLRRICECDKYVRRGAWKFGDFKLTTKFSGKRVGIIGLGRIGLAVAERAEAFDCPISYFSRSKKPNTNYTYYGSVVELASNSDILVVACPLTPETTHIINREVIDALGPKGVLINIGRGPHVDEPELVSALVEGRLGGAGLDVFEREPEVPEKLFGLENVVLLPHVGSGTVETRKVMADLVVGNLEAHFSGKPLLTPVV", "function": "Catalyzes the NAD(P)H-dependent reduction of 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4-dihydroxyphenylpyruvate to 3,4-dihydroxyphenyllactate in the biosynthesis of rosmarinic acid. Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. NADP is the preferred substrate.", "AFDB_id": "AF-Q65CJ7-F1-model_v4" }, { "swissprot_id": "Q9D5U8", "sequence": "MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGGTARSPLEPADKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQPKDRPGVQIKLSWSQKIKSWTAKKKRKLYQLVIDIIMMNRVCKMFRQGLRGFREYQIIEPVHKKHPDFSFWDKKKQGRISFVTEDFAAQEGHFPPRAISITQKKPSWRTHQEIQDLCNILQALDCYRSYTESLQLLLAKVIRFERFGRRRVIVKKGQMGNSFYFIYLGTVAITEDEDGSSAFLDPHPTLLHRGGSFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANKLGDEVQKETQYRYNFFRNLDIFQSWSEEKLWKLVALGRIERFSYGQMVSKDFMNSAFITFICQGNCEILRLVALGDCSAYYKWVWQQLELLDHKPLRIHDNEISPKERFKELQIKSYPLQDFTYLKLLRLQKAREQQGIDFHGKINKVENTLPKLLGPKIKSRFGHLVKCSMVNTKFGELPKEAIVGVYMKIHKTEEGEIVGLHQAFVPEIQRDCRPFILLSLGSELIQVRKEKFYDMVDEETRAKIIKMDVDYPSDEDLCQSFLKENDYIVFRKDLLRLLVEPLNKSPFIPVQTKKKEIYNHKSLFLDLCSLEKKVKQHYPIFLAPQKYLPPLRVVQAISAPRHKIQELLPQYKNAGVLI", "function": "Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.", "AFDB_id": "AF-Q9D5U8-F1-model_v4" }, { "swissprot_id": "P16157", "sequence": "MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP", "function": "Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.", "AFDB_id": "AF-P16157-F1-model_v4" }, { "swissprot_id": "Q9ZVD2", "sequence": "MAERVYPADSPPQSGQFSGNFSSGEFPKKPAPPPSTYVIQVPKDQIYRIPPPENAHRFEQLSRKKTNRSNCRCCFCSFLAAVFILIVLAGISFAVLYLIYRPEAPKYSIEGFSVSGINLNSTSPISPSFNVTVRSRNGNGKIGVYYEKESSVDVYYNDVDISNGVMPVFYQPAKNVTVVKLVLSGSKIQLTSGMRKEMRNEVSKKTVPFKLKIKAPVKIKFGSVKTWTMIVNVDCDVTVDKLTAPSRIVSRKCSHDVDLW", "function": "Required for plant immunity against the bacterial pathogen Pseudomonas syringae pv. tomato DC3000 (Pst DC3000).", "AFDB_id": "AF-Q9ZVD2-F1-model_v4" }, { "swissprot_id": "A5UL31", "sequence": "MLRRINIVDNPNIGVFILATDDLAVVPYNLLDEKVKLIEETLEVDAVKSSISGCNLIGSLAVANSNGIVVSPHVLDREVKQFEELGLNVATIPGNYTAVGNIVAANDTGAIVSPFLSDEAVKVIEDTLDVNVESTSMVGSDIIGSLITVTNKGFLMDKNATETEVDFARDVFGVEGDIGTVGRGISLVGACSLANSSGAIVAKESTGPEMARVEEALGFLDDL", "function": "Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.", "AFDB_id": "AF-A5UL31-F1-model_v4" }, { "swissprot_id": "C1A8U3", "sequence": "MSFVKMTGSGNDFVFFDGRTTPIDLVTQPEAIKAICNRYNGIGADGLVVLEPLQEEADVRVHYYNSDGTAADLCGNATLCSTAISAQWGITSASGMRLATGAGLINSRIDGLPAIALQPITDIRPDMPIAPATAQGRRVGFAVAGIPHLVILCEDADAVDVAGAGPALRRHEATGPAGANVNWVSPRPDGSWRYRTFERGVEGETLACGTGAVATAVLLRSWGLSDGATTTIRTSSGRDVEVDLEPLTAPDGRSLEGFRPTLRGEGRVVFRGEIAGL", "function": "Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.", "AFDB_id": "AF-C1A8U3-F1-model_v4" }, { "swissprot_id": "G2TRT0", "sequence": "MELEAYIQSLGLGIESYSQSATQFHDEANQSFNIPISTIIKLKEACRELETSKVVAKSLNWSHLLRVISLLWEKDVSLELMKLLANCLRQVPSISVQIVHNESLKQLTTSVFEVRAPKVLSLISTFNDDLERRVVFMRFLFILLSTQTDDICLDMRQVRTQLIQMLKKMWTLNSSPSNNSQDNEMVLTEILRLLFPISKRSYLKEEDEQKILLLVIEIWASSLNNNPNSPLRWHATNALLSFNLQLLSLDQAIYVSEIACQTLQSILISREVEYLEKGLNLCFDIAAKYQNTLPPILAILLSLLSFFNIKQNLSMLLFPTNDDRKQSLQKGKSFRCLLLRLLTIPIVEPIGTYYASLLNELCDGDSQQIARIFGAGYAMGISQHSETMPFPSPLSKAASPVFQKNSRGQENTEENNLAIDPITGSMCTNRNKSQRLELSQEEKEREAERLFYLFQRLEKNSTIQVTNPIQQAVNSGFIDVVFCLIFQMSSESFIYHCYHSFVGPIHILLLMFSTFKFHEILHFIKISKAS", "function": "Probable guanine nucleotide exchange factor (GEF).", "AFDB_id": "AF-G2TRT0-F1-model_v4" }, { "swissprot_id": "P08619", "sequence": "MEAPALEQRQSLHDSSERQQRFTSLILPNGVGCSSREEPQGSGGLLVPHNDNDIDNDLASTRTASPTTTDFSSSSSDDNSTTLETSVNYSHSSNTNTNTSCPPSPITSSSLKPAYPLPPPSTRLTTILPTDLKTPDHLIRDPRLIRLTGSHPFNVEPPLTALFEHGFLTPQNLHYVRNHGPIPSSVATPPATINKEEDDSLLNWEFTVEGLVEHPLKISVRELMDASKWDNVTYPVTLVCAGNRRKEQNVLRKSKGFSWGAGGLSTALWTGVGLSEILARAKPLTKKGGGARYVCFEGADQLPNGTYGTSVKLAWAMDPNKGIMVAHKMNGENLHPDHGRPVRVVVPGQIGGRSVKWLKRIVVTKGPSENWYHVFDNRVLPTTVGPEESGEKTEEMERVWRDERYAIYDLNVNSVICEPGHGEVVSLRGDEGAGTYRLRGYAYAGGGRRVTRLEVTLDQGKSWRLAGIEYPEDRYREAQDGEELFGGRLDVSWRESCFCWCFWDLEIPLSELRKAKDVCIRAMDESLALQPKEMYWSVLGMMNNPWFRVVIHHEGDTLRFEHPTQPMLTSDGWMDRVKKEGGNLANGFWGEKVPGAEENVVKEEPVKEISMVDEKVTRLITLEELRQHDGEEEPWFVVNGQVYNGTPFLEGHPGGAASITGAAGQDVTDEFLAIHSENAKAMMPTYHIGTLTPSAPAALKSSSTSDPALSDPSRPIFLQSKTWNSAILTFKESVSPDTKIFHFALSHPAQSIGLPVGQHLMMRLPDPAKPTESIIRAYTPISDGTLERGTLRVLVKIYYASPTEDIKGGQMTQALDALALGKAVEFKGPVGKFVYQGRGVCSVNGRERKVKRFVMVCGGSGVTPIYQVAEAVAVDDQDGTECLVLDGNRVEGDILMKSELDELVERAKPMGRCRVKYTLSRPGAEWEGLRGRLDKTMLEREVGEGDLRGETMVLLCGPEGMQNMVREVLKGMGWKDEDVLVF", "function": "Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.", "AFDB_id": "AF-P08619-F1-model_v4" }, { "swissprot_id": "P34888", "sequence": "MLKSTQVILIFILLISIVESLSWLALGLAANRFDRDKPGTSCKSLKGLTRRQMRFCKKNIDLMESVRSGSLAAHAECQFQFHKRRWNCTLIDPVTHEVIPDVFLYENTRESAFVHAISSAAVAYKVTRDCARGISERCGCDYSKNDHSGKSQFQYQGCSDNVKFGIGVSKEFVDSAQRRVLMMKDDNGTSLLGPSQLSADGMHMINLHNNQAGRQVLEKSLRRECKCHGMSGSCEMRTCWDSLPNFRHIGMAIKDKFDGAAEVKVVKEDGIEKPRIVMKNSQFKRHTNADLVYMTPSPDFCESDPLRGILGTKGRQCTLAPNAIDDCSLLCCGRGYEKKVQIVEEKCNCKFIYCCEVRCEPCQKRIEKYLCL", "function": "Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1. Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons. Also acts with the Wnt ligand egl-20 to direct HSN neuron migration. Acts through the Wnt receptor cfz-2 to direct ALM migration. Also plays a role in axon growth and guidance in HSN and male CP neurons. In addition, together with Wnt ligand cwn-2, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1. Probably by activating the Wnt/Frizzled pathway, may regulate vulva development. May act redundantly with other Wnt ligands such as cwn-2 and mom-2 to control seam cell polarity.", "AFDB_id": "AF-P34888-F1-model_v4" }, { "swissprot_id": "P33700", "sequence": "MTAAAPTDVCIIISAKNAADTIARAVASALAEPEAAEVVVIDDGSTDDSASVARAADDGTGRLNVVRFEENRGPAAARNHAIAISHSPLIGVLDADDFFFPGRLGQLLSQDGWDFIADNIAFIDAAQAATAHGRIDRFAPTPRLIDLVGFVEGNISRRGVRRGEIGFLKPLMRRAFLDQHGLRYNETLRLGEDYDLYARALANGARYKIIHSCGYAAVVRGNSLSGSHRTIDLKRLYEADRAILAGSRLSSDAEAAVRRHERHIRDRYELRHFLDLKNQQGFGRAFGYALTHPAALPAIIGGILADKTERFRPSGSPAPVALGGKGDVRYLLETLAVDQPQK", "function": "Glycosyltransferase required for the synthesis of succinoglycan (EPS I). Needed for the addition of the sixth sugar (glucose), catalyzes the formation of a beta-1,6 linkage between the fifth and sixth sugar.", "AFDB_id": "AF-P33700-F1-model_v4" }, { "swissprot_id": "Q8GYX9", "sequence": "MGREVVEVLMDRNADVSSARVHVAPKIAAEETDEEFEVKECTEEKSLSENAPNVGSAERVGAQKSPKTRNGNAKVSKQDAPLLAVRKPLQPENKKHIDDEDNCSIASSVATSMRMGKSGLTYGSAPTFRSAQRAEKRKEYYQKLEEKNQALEAERNELEQRQKDEQEAALKQLRKNLKFKAKPVPNFYYEAPPAKPELKKLPLTRPKSPKLILSRRKSFSDAVSSSSREEILKTVSNRNRHSTGTVQNKDDDHRNKNTNAAHDSPRVRSGKGKSGLKPVNESSEEA", "function": "Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules. Modulates both rotational polarity and anisotropic cell expansion during organ growth. Promotes clockwise root and etiolated hypocotyls coiling, clockwise leaf curling, but left-handed petiole twisting.", "AFDB_id": "AF-Q8GYX9-F1-model_v4" }, { "swissprot_id": "Q9ZUD9", "sequence": "MAAQVEIEDQTSVTNLDNGEIFDSISDDADSSVSHAGSSFSSSSLILLGEGNPEHDVIKTCLLSGMGVVSSDTTIVTISKNSSERGITTRAKFLAFRIFTDAVARKHGGDANVKYGWYAGSRDEIQRIISYGFSNRDVGKFENDGGSHGIGIHLVPSKCSLLAASATEQDEEGLRYLLLCRVILGKPEIIISGSKQSYPSSAEFDSGVDDLHNPRNYVIWSCNMNSCILPSYIVSFRSPRLRVSRGGFASRPSSPWVSFASLMSMLSTSMDPSRMNLIIRTYDDFRKRKIRRDQLVRKMREVAGDNLLAEIIKNHKNRNKVTN", "function": "Probable inactive ADP-ribosyltransferase that may be involved in stress and developmental responses.", "AFDB_id": "AF-Q9ZUD9-F1-model_v4" }, { "swissprot_id": "Q94CG5", "sequence": "MLQRAASNAYSWWAASHIRTKQSKWLEQSLHDMQGRVESVIKLIEEDGDSFAKRAEMYYKKRPELINFVEESYRAYRALAERYDHLSKELQTANNTIATIFPEQIQLAMDEEDEYGAPKMPKDFLQMPASGSNIPKVPPKAPIKDLKGLMSTASKQKQGKQSSKIEDAAKSGLSKNEAIEEIDKLQKDILALQTMKEFIRSSYQSSLEKFRGLENQIMEKQQKICELEDEFGEGRVIEDAEACTLMAEAALQSCQETVTQLQEKQESYTQEAREEFKKIEDACNKLNSFRHKYLGDQIDEAKVYISPIQEVDKEIESLQEKIKDQIDATSKGSLTMSQLAEKIDELVNKVVSLETAVSSQTLLLERFRAEADELQAQVQTLEDDKAALTDTHNLNIRVTAIEAKLQNIENLNKDVVNQNSCLRTHFVEARANIDHLSDKLSSVQPDEEIDGTDSSPDQVIALAEIKLEEESLKQKDHPSSAEGLKNLSTIKAEGPKNLSTIKTEGPKSLSTIKAEGPKNLSTIKAEGPKNLSTIKTEGPKSLSTIETEVPKNLSTIKTEDKEVRKQQGSSTVVSDKKTTMKHVTFAQPTPAEKGDEKVSAQSGNTSVYETHTQKSAEKDDELNWQQMLLSGLDDKENILLNEYTAILKNYKEVTKKLSDIEKKDRDTEFELTLQTRELKSAIAKRDEEIHNLRQKLSLMQQGNASENKALKEELLDPSDPSSARGLKPEDLPQIKDGDDEEDVKTILVDQRATVSPLEGKLRMSIDAILDENLDFWLRFSSAFHQIQKFKTTVHDLQNEISKARDKEMQGNSPRVDVKSEIRPLYKHMKEIQNELTVWLEQTLSLKDELERRFSALCSIQEEISKGLKEEVEDETTFSSHQAAKFQGEVLNMKHENKKVREELEAGISRVTILQEDVEKTVTQLDQEFGLTGNQSQLMQSVSKSRIPLQSFIFGTKPKKEKRSLFSRMNPNRKF", "function": "Probably involved in the receptor-like kinase-mediated signal transduction pathway.", "AFDB_id": "AF-Q94CG5-F1-model_v4" }, { "swissprot_id": "F4I2S4", "sequence": "MASMSSGDESLRLCMFDLRRGQTEGQELEKILFFYPADLDFSTQLSVIGLSEGLITFTRLFSPEAACEVIEAERHSHVFYEAEPDIWMVMVVEKNKETGAIWRIDALRRVLKEVHSLFVMFHGSIRALIEKEPTGGLTRSLLYPFITDYLSTFQIWSLSEDCCCEFFVGKKLQLPTFRETLRERGTVQMLTLARDTAVEVQSLVQVLDSCAGSLRCHSMILFQDLLVSTTLSADDTVDLFTFAVMRLTSKALSSDTSSWSYLRKGPGSSEISSRSNLAPVGSIDSLHSRNGNNMHHVIRPLQNDKWTKGKDGFLITDIWGLETGGSPDSAIPTIWLQQTQERMYLLAYQHKSLTLLLLMPTNAIVNGDLSISAVKQQVIEDASLRILKIEENISRGWGGENAYHIKGYRYLVVDNDTKVSRSSPSGKVTTLAKESLLALNKLREEVDSEKSRAKGQEKDMEICIRAKNNVWVIARVTRGKELYMALEKGSDTLLDTTDAVGRFSNRYCSGAFLMD", "function": "Plays an important role in membrane trafficking through the secretory apparatus. In complex with MON1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.", "AFDB_id": "AF-F4I2S4-F1-model_v4" }, { "swissprot_id": "P18852", "sequence": "MTSVQNSPRLQQPQEQQQQQQQLSLKIKQLKLKRINELNNKLRKELSRERITASNACLTIINYTSNTKDYTLPELWGYPVAGSNHFIEGLKNAQKNSQMSNSNSVCCTLM", "function": "Implicated in the pheromone A- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response.", "AFDB_id": "AF-P18852-F1-model_v4" }, { "swissprot_id": "O53732", "sequence": "MTVETSQTPSAAIDSDRWPAVAKVPRGPLAAASAAIANRLLRRTATHLPLRLVYSDGTATGAADPRAPSLFIHRPDALARRIGRHGLIGFGESYMAGEWSSKELTRVLTVLAGSVDELVPRSLHWLRPITPTFRPSWPDHSRDQARRNIAVHYDLSNDLFAAFLDETMTYSCAMFTDLLAQPTPAWTELAAAQRRKIDRLLDVAGVQQGSHVLEIGTGWGELCIRAAARGAHIRSVTLSVEQQRLARQRVAAAGFGHRVEIDLCDYRDVDGQYDSVVSVEMIEAVGYRSWPRYFAALEQLVRPGGPVAIQAITMPHHRMLATRHTQTWIQKYIFPGGLLPSTQAIIDITGQHTGLRIVDAASLRPHYAETLRLWRERFMQRRDGLAHLGFDEVFARMWELYLAYSEAGFRSGYLDVYQWTLIREGPP", "function": "Involved in the biosynthesis of the tuberculostearic acid (10-methylstearic-acid or TSA), a constituent lipid of the mycobacterial cell wall. Catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (SAM) to the double bond of oleic acid in phosphatidylethanolamine or phosphatidylcholine to produce TSA.", "AFDB_id": "AF-O53732-F1-model_v4" }, { "swissprot_id": "O13927", "sequence": "MENQVSSFLIDSPMEWKTYMKSLSDDNPSFGDVTVNLTKISVSSKNAKSYAEEMYNYVTQEMVFISERSRLLLRAKRRLYKNQSLMKKTSVSTSNTVKMVFMSLAKQIEQMLKFCMMVYSKLCEAFETTLKVAKEFQICDSSQEWFFQFQLGYHRKQMELQMLSFVAEWLVLTQHYTDALNDSAKTLYDIMESSHKAAQKV", "function": "Required for correct meiotic chromosome segregation and recombination.", "AFDB_id": "AF-O13927-F1-model_v4" }, { "swissprot_id": "P36144", "sequence": "MVESNDIIKSGLAEKALKALILQCEENPSLKNDKDIHIIINTGKKMGINRDNIPRIIPLTKYKLFKPRDLNILLITKDPSALYRETLTKDEHTSELFKEIISVKNLRRRFKGSKLTQLYKDFDLVVADYRVHHLLPEVLGSRFYHGSKKLPYMIRMSKEVKLKRQQMVEKCDPIYVRAQLRSICKNTSYIPNNDNCLSVRVGYIQKHSIPEILQNIQDTINFLTDKSKRPQGGVIKGGIISIFVKTSNSTSLPIYQFSEARENQKNEDLSDIKL", "function": "Involved in rRNA-processing and ribosome biosynthesis.", "AFDB_id": "AF-P36144-F1-model_v4" }, { "swissprot_id": "D2H9U0", "sequence": "MGGCNPFLKAARTLCPRIMPPLLFLSAFIFLVNVLGGAPGHNPDRRTKMISIHSLSELERLKLQETAYHELVARHFLSEFKPDRALPIDRPNTFEKWFLILRGQQRAVSLKTFGIRLEEVLVNELTRRKHLELTAAMQIEESTGQASGRRRGNVVQRLFGRIRRFFSSRRDEPSLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCSFIEKHGLSAVGIFTLEYSEERVRELREEFDQGLDVVLDDTQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVSGNRMTSTNLALVFGSALLKKGRFAKRESRKTRLGIDHYVASVNVVRAMIDNWDILFQVPPHIQKQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVENSAEAWAAVLAQSKPFDEGSSEEPAVPPGTAHSHDDEEGAGNPPIPEQDRPLLRVPREKQAKTGIGYFFP", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.", "AFDB_id": "AF-D2H9U0-F1-model_v4" }, { "swissprot_id": "Q6A7E7", "sequence": "MPSSLEKLSTNRVKLTIEMPFDELKPSLDKAYKDIANQVNVPGFRKGKVPAPVIDQRFGRGVVLQEAINDALPAAYGKAIEENTVVPLGQPEIEVTKLEDGEVVEFTAEVDVRPDFDLPDVSAISVEVPAVEVPDEDVDERVETLRQRFATNTEVERAAAKDDLVTIDLAGTRDGEVLEDATASGVTYKVGSEGMLEGLDEAVTGLKAGESAEFHSTLVGGPLRGQDADIKVTVTKVCEQELPAVDDDFAQLVSQFDTVDEMRADLRTALENMARLDQAADARDKVLEEVISKIDIELPTNLIDSELEARRQQVNQQLAQAGMTVEEYLEDSEEEVDNADDFWAEIEKRSLDALKAQIVLDKMADDDEIGVEQNELTELLFRKAQQNGTSPEEEAQHMMQHNHLPDWMQEIRRGKALASMVGAATVTDSKGNALELDRIQPDGTIADKQAEEDAPAEDSAEKADGKATEESKAEEKAPAKKATTKKISAKKSAGAKATTKKVVDAKSDDKPAAKKPAPKKKTAAKDDKSK", "function": "Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.", "AFDB_id": "AF-Q6A7E7-F1-model_v4" }, { "swissprot_id": "P0A9I3", "sequence": "MTLSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGEEFTFIMLLSGSWNAITLIESTLPLKGAELDLLIVMKRTTARPRPPMPASVWVQVDVADSPHLIERFTALFDAHHMNIAELVSRTQPAENERAAQLHIQITAHSPASADAANIEQAFKALCTELNAQGSINVVNYSQHDEQDGVK", "function": "Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity.", "AFDB_id": "AF-P0A9I3-F1-model_v4" }, { "swissprot_id": "Q86W56", "sequence": "MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPGRAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQHNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPEQFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKSCDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTKGGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKAEDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCAETADHSGQRTGT", "function": "Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.", "AFDB_id": "AF-Q86W56-F1-model_v4" }, { "swissprot_id": "Q8S8K8", "sequence": "MAGRISCCLNLPPLDSNSAQSLASLLKTTSKISCRRTENETEPRKNKCSFVLGVAATVVIGGIQINDVASVEAAVVKSPVEEMAAGVVPPRRWSDKRTCPPWLENSLETIVPENLPRPSAHRRLELAGLAKGDAPPVGVVMTRVNRGGCFSV", "function": "Triggers stress-induced chloroplast degradation, independently of autophagy and senescence-associated vacuoles. After targeting to the chloroplast, triggers its destabilization and subsequent disassembly, inducing the formation of CV-containing vesicles (CCVs) carrying stromal proteins, envelope membrane proteins, and thylakoid membrane proteins which are released from the chloroplasts and mobilized to the vacuole for proteolysis.", "AFDB_id": "AF-Q8S8K8-F1-model_v4" }, { "swissprot_id": "P00738", "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN", "function": "The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.", "AFDB_id": "AF-P00738-F1-model_v4" }, { "swissprot_id": "Q9DCJ7", "sequence": "MFLARLTSRLARTVVPWAGFSRSCPGSGVIGSYAFRPLYSLQPASPSRAASLPGKRTQSELEEFLVPRKMAISPLESWLTAQYLLPRRNVEVPVTLAPSQFYECPPRQGEEEAQQGVREAWDATPVQCKNVLKIRRRKMNHHKYRKLVKRTRFLRRKVREGRLKKKQIKFEKDLKRIWLKAGLKEAPENWQTPKIYLKNK", "function": "May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.", "AFDB_id": "AF-Q9DCJ7-F1-model_v4" }, { "swissprot_id": "Q8W4J3", "sequence": "MSLIHLFLLLGLLSLEAAASFSPGSRSILRDIGSNVADQKDNAIELNATNFDSVFQDSPAKYAVLEFFAHWCPACRNYKPHYEKVARLFNGADAVYPGVVLMTRVDCAIKMNVKLCDKFSINHYPMLFWAPPKRFVGGSWGPKQEKNEISVVNEWRTADLLLNWINKQIGSSYGLDDQKLGNLLSNISDQEQISQAIFDIEEATEEAFDIILAHKAIKSSETSASFIRFLQLLVAHHPSRRCRTGSAEILVNFDDICPSGECSYDQESGAKDSLRNFHICGKDVPRGYYRFCRGSKNETRGFSCGLWVLMHSLSVRIEDGESQFAFTAICDFINNFFMCDDCRRHFHDMCLSVKTPFKKARDIALWLWSTHNKVNERLKKDEDSLGTGDPKFPKMIWPPKQLCPSCYLSSTEKNIDWDHDQVYKFLKKYYGQKLVSVYKKNGESVSKEEVIAAAEEMAVPTNALVVPVGAALAIALASCAFGALACYWRTQQKNRKYNYNPHYLKRYNSNYMVMNTFSNTESEREKER", "function": "Sulfhydryl oxidase involved in the regulation of cation homeostasis. Positively regulates shoot accumulation of K(+) and inhibits accumulation of toxic cations. Acts at the level of root K(+) efflux systems involved in xylem loading (root symplast-xylem interface).", "AFDB_id": "AF-Q8W4J3-F1-model_v4" }, { "swissprot_id": "D0CY60", "sequence": "MTLENVLEAARHLHQTLPALSEFGNWPTDLTATGLQPRAIPATPLVQALDQPGSPRTTGLVQAIRSAAHLAHWKRTYTEAEVGADFRNRYGYFELFGPTGHFHSTQLRGYVAYWGAGLDYDWHSHQAEELYLTLAGGAVFKVDGERAFVGAEGTRLHASWQSHAMSTGDQPILTFVLWRGEGLNALPRMDAA", "function": "Able to cleave dimethylsulfonioproprionate (DMSP) in vitro, releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere. The real activity of the protein is however subject to debate and it is unclear whether it constitutes a real dimethylsulfonioproprionate lyase in vivo: the very low activity with DMSP as substrate suggests that DMSP is not its native substrate.", "AFDB_id": "AF-D0CY60-F1-model_v4" }, { "swissprot_id": "Q4UNC8", "sequence": "MSLCTLEINLSAIKNNYLLLQDICKTSLVGAAVKANGYGLGAVQISKALIEENCRHFFVASSEEGVNLRKALASWHESVFRHCEKNYTVIRRSNPVKNSVSQNFFNYFSGLQQCFAPRNDGSSIHATTPKALDNDVNILVLNGVFEHDALELIEYNLTPVLNNLKQIEIWQKFSNLKNRLLPCYLHFNTGINRLGLTHNEIEQLINNRDLLKGLDLQYIISHLAVSEEIDNPYNLEQLNRFKTYLQYFPNVKASLANSGGIFLGQDYHFDLARPGAALYGLNPVIDLSNNLSYKEEFEGDTERRTAAYINVREDSSTGSTYKLPLEGGYSRGLQNPVTLKAPIIHLQNLTLDSHIGYNMTFTTERDSVIATLPLGYADGFSRNFSNQGEVFINGRSVPIVGRISMDLINIDVTDLPPLDIFLGQEAEIIGNYCTPDKIASIIGTIGYEVLTSLGSRYKRIYK", "function": "Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.", "AFDB_id": "AF-Q4UNC8-F1-model_v4" }, { "swissprot_id": "Q9QYP2", "sequence": "EDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYILRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYILVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELRLSRALDNNRPLEAIMSVLVSDGVHSVTAQCSLRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGHCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPFCQVTTRSFPARSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVSVDGCDTGVALRFGAMLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRHFVGCMKNLQVDSRHVDMADFIANNGTVPGCPTKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQRFLGSSLVAWHGLSLPISQPWHLSLMFRTRQADGVLLQAVTRGRSTITLQLRAGHVVLSVEGTGLQASSLRLEPGRANDGDWHHAQLSLGASGGPGHAILSFDYGQQKAEGNLGPRLHGLHLSNMTVGGVPGPASSVARGFRGCLQGVRVSETPEGVSSLDPSRGESINVEPGCSWPDPCDSNPCPTNSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSACTRKPSAPHGYICECLPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPSSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSVTFSELKGFAERLQRNESGLDSGRSQRLALLLRNATQHTSGYFGSDVKVAYQLATRLLAHESAQRGFGLSATQDVHFTENLLRVGSALLDAANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGTKLPRYEALRGERPPDLETTVILPESVFREMPPMVRSAGPGEAQETEELARRQRRHPELSQGEAVASVIIYHTLAGLLPHNYDPDKRSLRVPKRPVINTPVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALMITFLFLTLLRALRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNASPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLYILSARASCAAQRQGFEKKGPVSGLRSSFTVLLLLSATWLLALLSVNSDTLLFHYLFAACNCVQGPFIFLSYVVLSKEVRKALKFACSRKPSPDPALTTKSTLTSSYNCPSPYADGRLYQPYGDSAGSLHSASRSGKSQPSYIPFLLREESTLNPGQVPPGLGDPSGLFMEGQAQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEAAFPGEQGWDSLLGPGAERLPLHSTPKDGGPGSGKVPWPGDFGTTTKENSGSGPLEERPRENGDALTREGSLGPLPGPSTQPHKGILKKKCLPTISEKSSLLRLPLEQGTGSSRGSTASEGSRNGPPPRPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH", "function": "Receptor that may have an important role in cell/cell signaling during nervous system formation.", "AFDB_id": "AF-Q9QYP2-F1-model_v4" }, { "swissprot_id": "A2SJR5", "sequence": "MRGGAHGPGDRAGRCREHRQDHAGPCAGAGAPFARPAGHAGGRVPARVLRRARPHAAARGTGRHRRRAMASHRGRRAGRSHRAGRHHAADDRGLQRVRVRRPQSLPPGARAPAPLRPHAADRPRPGLAARRPAARRRPGARPGRPLGPRRAGLCRAALFGGLWRRLGAHGSRCGCAAPAAAPARPGGPRARRPAAAWPLPRMPAARMRTSVVRVRGEAPIAMSEPDSSSPPAHPPRPIRSFVLRAGRMGSGQTRALAELGPRFVLPFQREPLDPQTVFGRRAPRVFEIGFGMGDATAQIAAARPDTDFIGCEVHTPGVGALLKQIGERELTNLRIVQHDAVEVLDHMIEPGSLAGIHLFFPDPWHKKKHHKRRLVQPAFVERLVTRLAPGGYLHCATDWQPYAEQMLEVLGAEPALRNSADGYAPRPEYRPLTKFEQRGLRLGHGVWDLVFTKHQGRSASKQCTATSSP", "function": "Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.", "AFDB_id": "AF-A2SJR5-F1-model_v4" }, { "swissprot_id": "F9XMW5", "sequence": "MVFCTYCGQSFTRDEHLERHILTHTNVKPFKCFTCHMSFARRDLLQRHYTVHGRDQNQNEIPAVNGMIPKSAGRTPIACSNCAKTKTKCDKKFPCSRCAGRNLRCTLRPTRRASKNANRVGATLESATDVPTEVTTVNVEATSKDTRAQENSSSPSSQKSGTPISIGPIMEETPDIAPPQPFTEQVNGGPTPPEFSPDLQESFMDHNLMSGFPGLTNPSKDSSDDGSSPRFLLDWSQMQMPLGYDNMIQSDLMLDPELSFDPNSVPLAPHADGILSIMPELANGGMESLITPFETPKMSRSFVELGLGNSNPAFHSHRHQSMPSVQSIPNSGNEMPAMIAAQDGWSAFRCTPTLPSSSCPKTAKLNLEQLEETLRNHEGWVSWSPRWEDNDLAGGGDHLTVMQLHESTRDKLLAIMQSFLHKALETHREGRGTSNGSHSPNPSGASNFVLLPPGRVLEYFLRSYSNSFERYFPLTSRSTLDANELMHCYNDRAASILVLLMIAQGAANIPSPEARMLTGGLTEACRISLFDLIERNIIMSGDPIVLHSALLFTVQAAWSGDKWQMDIAMGQRGMYFAMLRHSGVLDRSSHAASAQPQRTLEQLWTDWIQNESRSRLIYSWVMVDQDLALFHDTAPLFSVTEFGAPMPDADRLWHAKSAEQWSSTFERVHEFSSGFSSVGSGARPLSLRDLFRHFLDDDLIPMGIEMTPLQLRLLLHPLQSMVCQFSQLLSCFAPATYRTSISVHPNQAQPSSRNISQSSTRTRLAEVQALLQRWFDLAERYLKANPLCALMQTNLILFHLISLNAVTNFPEIERLARRENVDGTYHQLLWLHKRCIPDVEEAVFHCGQIFRLVRSMPRGVRPPWWAGAIYRVALILWTDSLTHKDALTSTSPQGNGMFPSPIAGPSFAIDALPPDHALIVRYLTKREGVPCVTKLDGSQMGLERAYPVLRHCVEVIDEGCSTRFSDAIRGKLERLSRG", "function": "Transcription factor; part of the gene cluster 29 that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment forming a dark layer in the conidial wall that protects the conidia from UV radiations.", "AFDB_id": "AF-F9XMW5-F1-model_v4" }, { "swissprot_id": "P77337", "sequence": "MSDDKFDAIVVGAGVAGSVAALVMARAGLDVLVIERGDSAGCKNMTGGRLYAHTLEAIIPGFAVSAPVERKVTREKISFLTEESAVTLDFHREQPDVPQHASYTVLRNRLDPWLMEQAEQAGAQFIPGVRVDALVREGNKVTGVQAGDDILEANVVILADGVNSMLGRSLGMVPASDPHHYAVGVKEVIGLTPEQINDRFNITGEEGAAWLFAGSPSDGLMGGGFLYTNKDSISLGLVCGLGDIAHAQKSVPQMLEDFKQHPAIRPLISGGKLLEYSAHMVPEGGLAMVPQLVNEGVMIVGDAAGFCLNLGFTVRGMDLAIASAQAAATTVIAAKERADFSASSLAQYKRELEQSCVMRDMQHFRKIPALMENPRLFSQYPRMVADIMNEMFTIDGKPNQPVRKMIMGHAKKIGLINLLKDGIKGATAL", "function": "Probably accepts electrons from YdiQ/YdiR and reduces a quinone.", "AFDB_id": "AF-P77337-F1-model_v4" }, { "swissprot_id": "G5ED39", "sequence": "MKITNKSVDKQHIEKLDELRKNVSCTVIGFAEQTAELQQEISELFIAEFGVNGPIDMNSLSKLARITSYYASSEYFQGLAKYQRTACKMFITWQTLRKEAMECRSKDREIFASIPAKLCFFYFYNGELCRAVVCLLDYIDLSDDTLAKEAALRWLMFLGETELIEKKLKTWKMDKSSKDMFSATEFAMNYLKKSEYRVEMLEKLMKLRDKVKSDPTRSFSRYELASYVSWLCSTLSNVPVGSALRECEFPDRVSHIQEAALKSDSLVRNRIPGLASSQFDNSVNASIWPFLDGHQEDSNYYVHIGSTIAWHFEMRRECALVNVTTAQTRDSMSAMILNLRVALKSASFFRVLQTTNTLAYYSSIIEEAGSEKNAKLMRVSCVNLLSSNPIIVRCSTPKETGATSRAHTPMAGSSVSEKQNTMRPDLADLLGDLELLDEQSFHPITRSCVCNVCTIYPLHSSFAAEYMMSYAIHSDFSQLSIKHFNDEFARIRERGMSSQVLMHRDSSVRPRPNIIQNEIFGMCVIRWLTKKLDSKESADEDTMEIFNNALKIVRYLQQRTTDMILAVTQLGRQLEFPMECNYSWMRPTIRKPRVKATIDCAVDILRAVSPFGRRPKVEKLEKNLQPFDKERFEKVRLAMRNEMNHYGHILYREWRCRLFAYVGRTSRDPWEAAYAWAESTQIGARNAVQSRLEKCKRGLVTMSGHDRFKTCVQSMPDEMTLVQIAMADDKTIYLVKLHADRDPIIMPLAHYSQAVELMDKFTFLLDEDEMIAKYPGDITPEEFWKRRKIVDGRMMTFVDEVQKHFLGVAASLLMPSGQLGPKAAELAIKIHKLSKGGLLLGEAKEMVYQSKLMDAKSWEALILRFCEMRTTDEKFKSFLPLMHRNSVEVMNQDDSIVTEKKYTYLVICPHLSQFCWERLPIFDEYPYVGRQVSIHSTFSQLEAMKSQEKQIPLQIDVQNAYYILDPDNNLGETQKRMVEYINKFNWEGTVGSAPKSNEISAALSQRDAFFFIGHGSGSSVMPRSVLKQSTCNAISLLMGCGSVRTIPQALGFDGKTAILDYAMAKCPLIVGCLWTVTDGEIDRFLIRMIDDCFEDSKSLTGIDKLRQLSEAMHEARSKARLKYLTGAAVVMYGLPVVAKQTTPFVEKDQRNLPQTPKTSARTSMRMETVPKTPKQEFVTSKSVPMTPIFSNNENKSPSRARMPSRVLKTPRQVKTFQEEDDEAPKRSTTRQLKPLVAPPIPATPTTRTTRSSARTPSRSRNL", "function": "Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase-anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating rab-11-positive vesicle trafficking at the plasma membrane at the cleavage furrow and midbody. Regulates centriole segregation during spermatocyte meiosis. Required for embryonic anterior-posterior axis formation.", "AFDB_id": "AF-G5ED39-F1-model_v4" }, { "swissprot_id": "O34918", "sequence": "MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSGGAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGARGALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKYPVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGTSKAYTVPGHVQFPE", "function": "May promote colonization of plant roots. May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. Has very low expansin activity (in vitro). No enzymatic activity has been found. Binds to peptidoglycan and to plant cell walls.", "AFDB_id": "AF-O34918-F1-model_v4" }, { "swissprot_id": "P23460", "sequence": "MTDNIMKDHRHIFLPQPVKADEKPGAFSERFGWKLLLDTPRKKNVYEGTKFMSQDFWPTPLVKTTAPKVKLIPADAPPQSAKFWKAPLLKDTPRQSNVIPGDFLPFSNTFGLATIQRR", "function": "Seems to be required for the LH-II stabilization.", "AFDB_id": "AF-P23460-F1-model_v4" }, { "swissprot_id": "Q8GYT8", "sequence": "MEARMKKYSREVSPERAKVWTEKSPKYHQKIKKVQIVYYLSKNRQLEHPHFMEVLISSPNGLYLRDVIERLNVLRGRGMASMYSWSSKRSYRNGFVWHDLSEDDLILPANGNEYVLKGSELFDESNSDHFSPIVNLATQNMKQIVVEPPSSRSMDDSSSSSSMNNGKGTNKHSHEDDELSPPALRSVSSSGVSPDSRDAKNSSSWCLAEYKVYKSEGLADASTQTDETVSGRSKTPIETFSRGVSTDEDVSSEPETSENNLVSEASCAGKERESAEISRNSVSPPFSNSASSLGGKTDTLESLIRADVSKMNSFRILEQEDVRMPAIPRLRASNMLMQLISCGSISVKDNNFGLVPTYKPKFGHSKFPSPFFSSSFMMGDLDRLSETPSLMGLRMEEKEYFSGSLVETKLQKKDAADSNASLKRSSSYNGDRASNQMGVAENGDSKPDSSKNNPSSRKASSILGKQQPLVSEKRRDSSEDTTKNIPCTTKTHDACSKRITESLRKPDSFREDEERVIKIDERLASGARVRIESKVPSEEP", "function": "SOSEKI proteins (SOK1-5) locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes, probably by guiding ANGUSTIFOLIA (AN) polarized localization.", "AFDB_id": "AF-Q8GYT8-F1-model_v4" }, { "swissprot_id": "O15446", "sequence": "MEEPQAGDAARFSCPPNFTAKPPASESPRFSLEALTGPDTELWLIQAPADFAPECFNGRHVPLSGSQIVKGKLAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPRSALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKKRKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGHTVTEPIQPLEPELPGEGQPEARATPGSTKKRKKQSQESRMPETVPQEEMPGPPLNSESGEEAPTGRDKKRKQQQQQPV", "function": "Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.", "AFDB_id": "AF-O15446-F1-model_v4" }, { "swissprot_id": "Q6CPW2", "sequence": "MSHLLVYDFMEHDLANVLIVVKPSTKSLVFVSLSGTKPKLLGDAKKFVSKVNSLSKNKGSIYTLKNKSILKSDDVAWLEQLSFDFLQILAGGIDSQTNIKCEYLLGTEFQKKVWETTKTIKAGATISYQQLAVLLGNPKAVRAIGSALAKNNIAVVIPCHRIIGSKGKLTGFRWGIELKESLLRQEQAI", "function": "Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.", "AFDB_id": "AF-Q6CPW2-F1-model_v4" }, { "swissprot_id": "Q0V6Q2", "sequence": "MAEAFTTVPAKSSPARFRYTKANPVKDPTTSFAGKTILITGPNAGLGFEAATKFARLGASKLIFGVRSLERGQEAKTKIEQLTKCKRDAIQLVQLDMGSYASIEKFAKSVTDEFPVIHAAVLNAGVAPPSYKLSQEGWEMSLQVNVISTAYLAILLLPKLRESGRAIGEPAYLEFVSSTGHGDVTTESVRDGKSILKKVNDPANFKFTAQYQITKLLEIWAMEHIAAKTSPKEVIVNSACPGLCKSSIGRDFGIVLRGLDAVFKGIFAQTAEAGSRILVSAVTAGTDSHGGFWALDAVSVPGELVTSDEGKALSKQFWAEVLDVLRKQNADVEAILNG", "function": "Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of the mycotoxins phomacins, leucine-derived cytochalasans with potent actin polymerization-inhibitory activities and monocot-specific antigerminative activities. The first step in the pathway is catalyzed by the hybrid PKS-NRPS phmA, assisted by the enoyl reductase phmE, that are responsible for fusion of the leucine precursor and the polyketide backbone to produce a 2-pyrrolidone intermediate. The polyketide synthase module (PKS) of phmA is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the leucine precursor. Because phmA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase phmE. Reduction by the hydrolyase phmG, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase phmD then yield the required isoindolone-fused macrocycle (Probable). A number of oxidative steps catalyzed by the tailoring cytochrome P450 monooxygenase phmB, the FAD-linked oxidoreductase phmC and the short-chain dehydrogenase/reductase phmF, are further required to afford the final products, phomacin D and phomacin E.", "AFDB_id": "AF-Q0V6Q2-F1-model_v4" }, { "swissprot_id": "Q9LGZ2", "sequence": "MASIPPDDDAAAAAAAGAAENGYGNGKGNGNGPAPRPPPAKRPRSVISAAQIRAEFEHHEAGVARVNNGSFGCCPSSLLDAQARWQRLFIAQPDDFYFHALQPGLRRSRAAVAGLVNAGDVAEVSLVDNATTAAAIVLQHAAWSFAEGRFSRGDAVLMLHYAYGAVKKSIHAYVARAGATVVEVPLPFPVASADAIIAEFRAALDVAKAGGRKVRLAVIDHITSMPSVVIPVKELVAICREEGVDKVFIDAAHSIGQVPVDVRDIGADFYTSNLHKWFFCPPAVAFLHTRKDDPIASQLHHPVVSHEYGNGLPMESGWIGTRDYSAQLVVPESIDFVNRFEGGIEGIRSRNHEKVIEMGKMLAEAWGTFLGTPPELCGSMVMVGLPGCLGVESDDDVMRMRTMLRKDFMVEVPIYYNSRRVEAQEMAKDKNGDAVTGYVRISHQVYNVTEDYEKLRDAVNKLVADGFTSSKLRPSQKQETMA", "function": "Catalyzes the production of hydrogen sulfide (H2S) from cysteine.", "AFDB_id": "AF-Q9LGZ2-F1-model_v4" }, { "swissprot_id": "Q09457", "sequence": "MVKSYTLAGLAAIACLLLAIGAVISTVYILNDISDFYSEAQEELVEFKDIANNIWEEMVFELTPEEMREAEDNDREKRSYEPEGPYQSETTTPSTTTSTAATTTEAAEDESGYDFVNDNGPPSSRPRKPEPPTMPRTIQGFRAPPPAATSTYRPPHGSNYDNYGREPASSRRPYPPQQPPSTSAPHSSPNNRTSLYNPQPPPKTGYPTNPRVPYNPPQPNYTRQPTYPEDNRAPYKPTRSPNTPPPRQPSGGYDSDGQTPPSSPRIYNTRRPNNHGPGYPEDQVPTAPPVPGQQRVPPTQTRNPPNPTNTRQPSRPVPPTSDGHIEATTPYNPSAQYPTGKRGSHPGFGPQRPRPGTRPRGNPCDQCSAQPNHCPSGPPGPRGRPGPPGFPGQDGPRGLRGLNGGYSGVQPSSYDPVIGCVQCPIGPPGERGPDGTPGVPGEDGIDGEQGVNGQDGQPGAPGAPGYHGMNGSPGTPGKPGLPGRNGQSCKSIPGPPGQPGVMGVPGRDGDPGTDGEHGQDGSPGIQGPPGRDGTSGPDGQPGVSAPGAPGTDGGYCPCPKRSSKFDFNDAYNDDEKRGLEEHRPRGYDSERAEEPRPRQTVRTNTYDENSGAEHQRRPNYEPSAEVAPPRQDRYEDEERVREPPPKRPPPPHRQTPHELYPEEQPYVRRPPPPQNRGNYEVERSREYVPEAPRPRQGYEHSSGYGGDDRKEQPKYMESRPVDEPRYETDAPSRSRPLKKVEIIRHPERGYDRRQPSYEDSKPRQEEPRRYETEAEPRYEEVPRKETHPPGFGRPKSEENPRETGRTYSEEAMPPVQQTEKYNGDKRKKNQPEYEDISKPEEDKERAMEKHHKKPNKFQEKQWEEHRKSQELRNSREHGGQVPVETSVPMQQVKPESSAEEKPVPPVHDNFQSSEKRAFSNENPLPSEQIPYRRRNRFYRNHYYEKFLV", "function": "Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway; perhaps in the formation of the adult cuticle. Required for proper strut formation within the unique medial layer of the adult cuticle (Ref.2).", "AFDB_id": "AF-Q09457-F1-model_v4" }, { "swissprot_id": "B5Y7W4", "sequence": "MEREKIFQELKNILKDTVTVEEEEITMESDLVNDLNLDSLDLVDLALSVEQVFGFEFSDEQLQQIKTVKDVVDIIESNLYTK", "function": "Carrier of the growing fatty acid chain in fatty acid biosynthesis.", "AFDB_id": "AF-B5Y7W4-F1-model_v4" }, { "swissprot_id": "Q58EX7", "sequence": "MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALEAEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV", "function": "Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.", "AFDB_id": "AF-Q58EX7-F1-model_v4" }, { "swissprot_id": "P22408", "sequence": "MEKKRSMTAAPAVAMTAVSMVLTVVVIVMWLGEAMPWAVALVVGLGLDGGWLATLAYERRLAARGDHSRAITGVGWGFGAVATGVLVAHALGEESAGAWLAVAWLPLAAKALWLVHGLWERTALTPTALDQIRDIQQDARDRAAVARAQLRAEAGTEVTRLEAVTGAGARVARVQAETAGELASAWSTLEEAREGEGTARALTCVTSRVTPTSPPSWRLPVWGPTEPVPAAIEGSADVVPLSNEEIDGIMSGLVDSGSYRVAAGRFRDMGYSAGEARLQASWRRVTREVAA", "function": "Involved in plasmid transfer.", "AFDB_id": "AF-P22408-F1-model_v4" }, { "swissprot_id": "C4R6W8", "sequence": "MNKFSSDSSRTTAQSTINKLLVNLIPGSQLNDAKVAKKAKKSSSAKIISDQIGSRMEFKRNEEKRRKFLKQNNLKKRKMKRKSKDLEAQLERIARLSNIKELQQMSEDSNDPLLDQVIDKKITALLSWTTDNSELGTEIEKLKKDILNTDNEEVRRRKSYRDEEREEAEFRSEVEKGSIAYPGLTPGLAPVGLSDDEDDEEEDESDGFDKEEEEDQFSE", "function": "Involved in ribosome biogenesis, probably through modulation of rDNA transcription.", "AFDB_id": "AF-C4R6W8-F1-model_v4" }, { "swissprot_id": "Q7NCE3", "sequence": "MNAASTVVKPVSAQSIPVQETFGPTIQGEGYWAGAVVDFIRLYGCPVGCPWCDTGYADGGPQLPRAVRTFSDLILELKSPRVVISGGEPFIHAALPALVEAIGRTGRAVAIETSGAFWQPVPDWAWVTLSPKEHVSPRHPVNPQMWRRANEVKIVIAGGAELDVYRRFLPPGVPVSLQPEWEARERTLPLTLELLKAHPRYRLSVQLHKYLQVP", "function": "Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.", "AFDB_id": "AF-Q7NCE3-F1-model_v4" }, { "swissprot_id": "Q7VUQ6", "sequence": "MWNDARTINLIANTLAVLAVAAMLLAGVAWVAQRPYFTLAAIEIESMPETEMHYVSTGAVRAAIAGRFGGNFFTVDLDEAREAFESVPWVRHATVRRIWPNTLRVRVEEQQPLALWNENQMINTWGEAFTANTGELADDMVLPHFTGPEGTESLVVQRYAELARWFAPLDMHVRELVLNPRYAWAVTLSNGMKLDLGRDPGADAPDPHGLPGALPFAARIQRFVQAWPVVSSRLEGRTVTQADLRYPTGFALALAPLPPEHASHSKSKPAKKR", "function": "Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.", "AFDB_id": "AF-Q7VUQ6-F1-model_v4" }, { "swissprot_id": "D6XTM9", "sequence": "MADGKVIDIEQKVPDFREQRRRKSRRRLVLYISILAFFLLFVYYFQSDYSTVGHVDVYGTDMVDEKWVVESSGLTDGVSMWSYPFHEAVEELMEHPVIVSVEAERNWPRSITLYVDEYRTVGYLRSAENGAFYPLLNDGSILNQEEFQGSHVDEPLISGMDAHSELGRLAHELDELDEMVTRRISEVVHEPDQGEHHLTLYTTDGFTVYTEINDFASNMTAYPAVAIQLNPEEEGILHMRMTPYFEREGQEEEEIEIEE", "function": "Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.", "AFDB_id": "AF-D6XTM9-F1-model_v4" }, { "swissprot_id": "A5FEP6", "sequence": "MRSIWTGSVSFGLINIPIKMFSAVQESSLDMDMLDKKDNANIKFKRVNENTGKEVDFANIVKGYMLNDKYVILDDSDFEAADAIKTKTIDIESFVLEKEIESIYYEQPYYLEPDKGAMNAYGLLRDALQASGKVGVTRFVLRNKESLAILKPYKNVIVLNRIRFEQEIRSTDELNLPPISKKATKEMDMAEKLIDQLTEKFDITGFKDEYTTKLLDIIKKKAKGKVQKTAPKMKVVHKQGDDLMSMLKASLETKKKKSS", "function": "With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.", "AFDB_id": "AF-A5FEP6-F1-model_v4" }, { "swissprot_id": "Q09918", "sequence": "MDERHEAAGETSEKPKVLFLLNSYYGPFYDDGDNTGVNVVDLYEAFKVFEENGFDIVIASDTGDYGFDDKSFRDPAIVDETQSIFSNPDCSLMKKLKNIARLDRLNPSDYVIVYIPGGYGCSFDFPHAKVVQDFLYRFYETKGIICAVAQANIALAYTTNSDGQALCTNRRVTGCTWKDEVQNGVLNVMNRLNFYSFGHIAENIGAIFESPPVYVEDPFIVEDGQLFTGSNTNSAKGVAMEAVRAVLNYDG", "function": "May catalyze the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS).", "AFDB_id": "AF-Q09918-F1-model_v4" }, { "swissprot_id": "Q75W84", "sequence": "MEMDDDEAILLDDIYALASTPNQTIVTSSFPQTVSPGFLARRNEALAMVEVAVQSTILILTVVGNAAVLAMIVSLSRHKDLGRMYTMIGHLSCADLFVAIFNLLPQLLWDVTHRFRGGRVLCKLVKYVQVVAMYASAYVLMSTAVDRYTAICHPMRSHTWTSTTAHYLVIGAWVLALVFAVPQLVIFDYVEVVPGSGVYDCVDHFRPRWTLPVYITWFALAVYVIPLVVLATIYLRICVVVWKSANRKSTPMINVAARTSGATEQPSLDDASVSFNVADGGGVDLDPSGGGGSLSRHAAQLSHRQQQQQANNVVLSRAKTKTVKLTLTVVISYLVCWAPFFVSHIWSAWDPHAPFEGTEMVITLLLGSLNSCINPWIYLAFSDQLRRKVTQCCPRSWGQRPSTLSHDSTDFRSGSRPTHS", "function": "Receptor for annetocin. Activation by annetocin may induce egg-laying behavior through calcium-dependent signaling.", "AFDB_id": "AF-Q75W84-F1-model_v4" }, { "swissprot_id": "P92029", "sequence": "MLRLCLPTRAGYVRNFSNDKPRKPETHYEVLNIRNDCSTREVRNAFVQLSKLYHPDVKSNAACPERTARFVQISEAYKTLIKPERRRDYDDSLLWQPSRSDRSPVGETVNPGQAWDVRPNYDPNPGPYYGIRGLKRVSNWQVAVVLMALGFVGALFGFTSVRSSFKLSRQIQDEISAEANSHHAAVVADAQKYGNEEQVRRMVDRMSRSPFNQSSAK", "function": "May play an important function during spermatogenesis and/or in the male genital tract.", "AFDB_id": "AF-P92029-F1-model_v4" }, { "swissprot_id": "Q6NE47", "sequence": "MRIAAIINARAGTVLRMSPSAVTERLSVVWGSLGHDAAIILAEGKDMGRMVRKACRDPDIRAIIIGGGDGSLSRALEHVLASGKSLGVLPLGTMNYMARQIGMPLDLAQAAVALAGAVQTPMDVGRVNDRYFLIRACFGAFPEFIQSRDRVRRKGGSFLEGALAGLSGVARRYRIVEAELSSPGGRARIATSFLMISNNLCRDSDPFLLERERMDGGSLGVYVGRSAGPVGLMELGLQAAMGRWASNEALFQGEMHWLEVQTEQRKPLISIDGEVEKMEGPFRFDILPGALSILVPK", "function": "Might phosphorylate lipids.", "AFDB_id": "AF-Q6NE47-F1-model_v4" }, { "swissprot_id": "O22802", "sequence": "MASYHVSHDSYQSPGPSPLYQPIIEAPPPPYPPTRTRYQDYYGGYGQPHPPPLRPYRSDHEYYGDGEYVGCFPFLRSCLTTLCCCWFVEQCCFRSRY", "function": "Involved in resistance to abiotic stress.", "AFDB_id": "AF-O22802-F1-model_v4" }, { "swissprot_id": "Q2RMZ4", "sequence": "MSEPLLRGLAAGDPPSATGPVTGSADKVADVLIVGGGLVGGTLACALAEKGVSVVVIDGEDPEALLAAGYDGRCSAIALACQRLLDTIGLWDLLGGESQPILDIRVVDGGSPLFLHYAQAEAQGPMGYMVENRLLRQAILTRLGRLPAATLLAPARMTALRRDLDGVSATLSDGQTVRARLVVGADGRRSQVRESAGIGIRTLGYGQTAIVLTVEHERSHRGCAVEHFLPAGPFAILPMPGNRSSLVWTERSDLVPGLLALPAEHFQAELERRFGDHLGWVRPVGPRFSYRLTLQAANRYVDHRLALVGDAAHGMHPVAGQGMNYGLRDVAVLAERLVAAQRLGLDPGAPALLAEYEALRRPDNLLMLAITDALVRLFSNDIAPVALARRLGIGAVERMGPLKRLFMRHAMGTLKLGPEPPRLMRGVPL", "function": "Catalyzes the hydroxylation of two positions of the aromatic ring during ubiquinone biosynthesis.", "AFDB_id": "AF-Q2RMZ4-F1-model_v4" }, { "swissprot_id": "P43459", "sequence": "MLTSKKEMQSSENKQEENLALLLTNYISYQNIVIFTGGNQFKIRNKKEFTEYTIESNSLFFLAKNTHWDMEIVGIDNSNPYRKIIIDDALIKLLHSISSDDSCYVKKKIFTANLNEMQLNIVSNIITDIKYSGNNKKIFKILYLLSFFNDYNDIVNVILSASSKSIVDRVIKVIELDISKNWKLGDVSSSMFMSDSCLRKQLNKENLTFKKIMLDIKMKHASLFLRTTDKNIDEISCLVGFNSTSYFIKVFKEYYNTTPKKYNGVYSITQGTLP", "function": "Could help in the transcriptional activator of eaeA expression in enteropathogenic E.coli. However, it seems that it is PerC which acts as an activator.", "AFDB_id": "AF-P43459-F1-model_v4" }, { "swissprot_id": "O49436", "sequence": "MPKCPIPIRISFFSYFLKESRILSSNPVNFSIHLRFSSSVSVSPNPSMEVVENPLEAPISEKMFKSAPKMGSFKLGDSTLSSMIESYANSGDFDSVEKLLSRIRLENRVIIERSFIVVFRAYGKAHLPDKAVDLFHRMVDEFRCKRSVKSFNSVLNVIINEGLYHRGLEFYDYVVNSNMNMNISPNGLSFNLVIKALCKLRFVDRAIEVFRGMPERKCLPDGYTYCTLMDGLCKEERIDEAVLLLDEMQSEGCSPSPVIYNVLIDGLCKKGDLTRVTKLVDNMFLKGCVPNEVTYNTLIHGLCLKGKLDKAVSLLERMVSSKCIPNDVTYGTLINGLVKQRRATDAVRLLSSMEERGYHLNQHIYSVLISGLFKEGKAEEAMSLWRKMAEKGCKPNIVVYSVLVDGLCREGKPNEAKEILNRMIASGCLPNAYTYSSLMKGFFKTGLCEEAVQVWKEMDKTGCSRNKFCYSVLIDGLCGVGRVKEAMMVWSKMLTIGIKPDTVAYSSIIKGLCGIGSMDAALKLYHEMLCQEEPKSQPDVVTYNILLDGLCMQKDISRAVDLLNSMLDRGCDPDVITCNTFLNTLSEKSNSCDKGRSFLEELVVRLLKRQRVSGACTIVEVMLGKYLAPKTSTWAMIVREICKPKKINAAIDKCWRNLCT", "function": "May play a role in embryogenesis.", "AFDB_id": "AF-O49436-F1-model_v4" }, { "swissprot_id": "O94486", "sequence": "MLVSNGGTGSAHEWDRTTIDYDIEPSSDTHAIEISSNDDYLHPLAQFKKSEEFDEVPTNTLIHEVPSFSDSASNIQSQRNLSPFKELEIVSKKKSEQTFSSAVDFSAINVKNLNLKSGLFDPEPPSYDPDYAFNQRSLQSDPGSDEMFRNFKKSISLEELKSSYKLASAEMCEPETRLSFLQLALQAEKSSSRRNREYVARKKEEAFDYLTSFVSQGNSFFGYSEALYLLAVCYGTGALRTEINEKEAYRLYKMAADLNHVQAAYRVAICLQMGFGVTQNTEEAIHYFFRAASGQHVGAMHRMALIYFRGLMSVKRDPVKAMYYLNLGALEADHEFPQALYDLAELYEHGSSYLDGLLELSPRKAFVLYHIAAKYGLKDAQLRVARCFELGQLECDINLVRSFVWYRRLARKRNPEAMWKLSQFYLNGVDDVIYPNPELANEWAKAAAYKNHHLASTFVQDVGKEDVFEKTSITISNEERKSRNSESLPKKKKRLSMLSFKRSKNRESCIIS", "function": "Involved in chitin biosynthesis.", "AFDB_id": "AF-O94486-F1-model_v4" }, { "swissprot_id": "P09891", "sequence": "MAGPQDRPRGRGPSSGRPQRPVGGRSQRDRDRRVLGQNFLRDPATIRRIADAADVDPDGLVVEAGPGEGLLTRELARRAGRVRTYELDQRLARRLSTDLAQETSIEVVHADFLTAPHPEEPFQFVGAIPYGITSAIVDWCLTAPTLTSATLVTQQEFARKRTGDYGRWTALTVTTWPTFEWQYVAKVDRTLFTPVPRVHSAIMRLRRRPQPLLRDAAARSRFADMVEIGFVGKGGSLYRSLTREWPRSKVDSAFARADVHHDEIVAFVHPDQWITLFQLLDGSRGGAARGPGDQRGRRGRPGGGPRPDGRAGGGPRRDAGGRRTGDGRGGRPRPPRGGQA", "function": "Involved in erythromycin resistance.", "AFDB_id": "AF-P09891-F1-model_v4" }, { "swissprot_id": "A0A1L9WVI3", "sequence": "MIAGLVLVVLLTKYLQRVFLHPLSKFPGPSIAAVSHLWEFWHDWVKNGTFLEGVADLHRSYKSPVVRIAPNHLHVNDVEVYHQVFKVNTNFYKAPYFYEAFGFATSIATITNPHRHKPLRTTVAPMFTGTAVDGMSDEMYDMVRKATDLLAARSTGTGNKFNVMQFLRCITTDVSCNLIFGETLDLVSNGYHSDRFLGNLDTFVENVWIMVHAPWIAQFALMLPNSLTDKIVPGYAYFREQCISWIDKVRARRAKGITLMRNGRPTLFDVLMDDNPDKNYKVPSKSELIDQAFLFAIAGTDTTSMATTFAVFHILNNPAVRERLCEELRGASAIIRDQYNYREVRKLPYLSAVIKEALRMSSPFPGRLPRVVPPEGMKLDNKFVPGGTIISISSRCIMDDPKIYPEPEKFLPERWMGENAKSMDRNMIAFGKGSRSCLGTNLAYLKMYTMLSTMFCRWDLRLVSPTDHKLRYLDHALIEMKSQVVVEILADHWTT", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aculenes, a unique type of norsesquiterpenes that contain a nordaucane skeleton linked to an L-proline moiety and are of mixed biosynthetic origin. The pathway begins with the synthesis of dauca-4,7-diene by the terpene cyclase aneC using farnesyl pyrophosphate (FPP) as substrate. The cytochrome P450 monooxygenase aneF then performs the initial oxidation at C-12 of dauca-4,7-diene to yield asperaculane D. Asperaculane D is substrate of the cytochrome P450 monooxygenase aneD for C-10 hydroxylation to yield asperaculane E. The cytochrome P450 monooxygenase aneG then converts asperaculane E into aculene D via C-2 oxidation. The monomodular nonribosomal peptide synthtase aneB adenylates L-proline and the thiohydrolase aneE transfers this activated L-proline derivative to aculenes D and C to produce respectively aculenes B and A. The dioxygenase aneA converts aculene D into aculene C, and aculene B into aculene A by introducing the 5,6-alkene moiety. Asperculanes A, B, C and F, as well as 14-prolyl asperculane C, might be shunt products of the pathway.", "AFDB_id": "AF-A0A1L9WVI3-F1-model_v4" }, { "swissprot_id": "Q09688", "sequence": "MKGFVVISRFILTLFILITPGLAGVVNYAENSEWNVPKYGNVLDSNCQGQKPVTFFGSVTEHVSNSWWIKLYDYMMTFISGEKLCMQNVAYEFEDISLCMDVVGSKCIPTLQSTDIEKVVNSTSAYLENSESDLTLGCFQIQRFQEESTLYIRALKSSEPVSCDTVRCIHFNHIPYV", "function": "Has a role in meiosis.", "AFDB_id": "AF-Q09688-F1-model_v4" }, { "swissprot_id": "W3X732", "sequence": "MYIQTQFASLLLLAGTSLASQVRKYNFTITSQWSSGDGHGRPVFMINGQSPGPLIEADEGDEIEVFVDNQLAAETTMHWHGIYQIDRPWNDGVPGVTQYSMQPRDTYTYRFTVQQQYGSYFYHGHFGPAFADGMRGPMWIAPAAWRPRPYELISDSSHDVEQMKKAEKHPFHVVISDWNAEPMDILLVMYRDTGIVPWCSNSIVLNGKGRTYCHSAELIESVGGPGRNTLGCLMQPDQELYSNEQVCEATQTDLEIFQAEEGHEWIWINFIHSGAHHELQISVDEHEIVVVAADGEFTYPQRVHAANCNLGERISILVHLNQKPGDYAIRVTSLRQEQVIQGLGILRYPGSSHGAQEAEPPATKPWVHLNGTLISDKLQQMDEMKLAPFPSRPPPPQSDHTLKFFVNMTGTGSWALNIGPHQAFRQQLPPLLWEEDSRGVTTYESDVQGGSMQNGSVVDIIFTNGANVNSQHPFHKHNNKAWVIGTGTGGFPWDTVDEAIQQGGMADSFNFVDPPIRDGCRLGNTTGDWTVIRYDIAFPAASMLHCHMIHHFGAGQQVVLLEGVESMAKIPAEMKDRVHSNFRPPLRYGPLD", "function": "Laccase involved the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment forming a dark layer in the conidial wall that protects the conidia from UV radiations. The first step of the pathway is the production of the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN or T4HN) by the polyketide synthase PfmaE though condensation of acetyl-CoA with malonyl-CoA. T4HN is not stable and easily oxidizes into the stable form flaviolin. T4HN is also substrate of the hydroxynaphthalene reductase PfmaG to yield scytalone. The scytalone dehydratase PfmaJ then reduces scytalone to 1,3,8-THN. 1,3,8-THN is then substrate of the hydroxynaphthalene reductase PfmaI to yield vermelone (Probable). Vermelone is further converted by the multicopper oxidase PfmaD to 1,8-DHN (Probable). Finally the laccase PFICI_06862 transforms 1,8-DHN to DHN-melanin (Probable). The roles of the 5-oxoprolinase PfmaA and the proline iminopeptidase PfmaB within the cluster have not been elucidated yet (Probable).", "AFDB_id": "AF-W3X732-F1-model_v4" }, { "swissprot_id": "Q99393", "sequence": "MVSLTTIEQSPVKCETTTEKESNDTRGTDSNENAETKETKKGFPFHDLAKLQKQYKNKSSRNESLVALIYLLGSMLSFCLLIFFTDFYLIPLFPTTTTMTDYIVFNFYLLNVFVFCMVHFIYHFVKNISLQQHLEHWQKFSYLSNINLLISSQITILYYLFYDYVFFFKIFTLLMNFIGLVAYFFILTDKLISSKRFNKTVFFISVSVVCCSLPLLTAIITFDGLENLKERIKVNAITWELVALVAASIIYVTRFPESLFRRNKKEEGWNHSEYLFHLLISGTAFYHFFILIQSYILMHSSLNQPELINFKS", "function": "ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.", "AFDB_id": "AF-Q99393-F1-model_v4" }, { "swissprot_id": "O76039", "sequence": "MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL", "function": "Mediates phosphorylation of MECP2. May regulate ciliogenesis.", "AFDB_id": "AF-O76039-F1-model_v4" }, { "swissprot_id": "Q9Y7J9", "sequence": "MEKKQDNEVELYSIDLKNRNESAKIKLAYAKALEESILCETRKIEQEIKDQVVQKENKTYFNNKFDNRYKLRDLEKNLAEEEVRITEMLTIQRQDIAIERRKNTNCFSESSQVDQYSVTETNLQYATNIGLNLLQQLRYLRLQLSEKEDLHKKLSVDNAHLIKQLDLLSSNMKTLMKEKTKVQGQRDLLEQRLQGLMKKLTEVESLTVSLNDEKNKLTLELTNLRICLHELQLNAEKGETIDESEDSKNTLVTEDENDDSVFLESSSDKYFDSSSFDAEQEEKHDFPIDPFLSLESNVQTSVSQSSAVLKSINLAKQELVSVNHLVADDTKTPSPNLSSEIIENTKADIKKSIRSLNKAVSPENSIDIEDETDRDDEFICFLLSYQQLQKALKSNLGLFQLSCLYPLSLNHLIQSFFQSLTSQISIKDIDSKNKQVIKLFKPTKSSDRQEIFELAQFEPRQKFPIDTNSSKCDMSASTEMHLKDTEKFANFKLKENILNHSSIYERDVSYLPALNKGGRENYLNNRVSSYRLVKPILNSYGNHVLNRIQHDILENHFCCLKNVKDFVCGANTISMQWNLQKNMEFISSVFSLIKNEVNDTSANSVILRTDALSNVATTRLKRKLTSAIIDCSIPRRRLRHYSNPEIAEFKNFRLSTDISHSNVRNSKKLCSNGSMNCMRQGKAVFPRKIPYQEHDWEQWEKIAQSSMFKNRSIASRQSLETSDVTLDINMSSRHSNGTSSMLFKDFTKHNNWEASTYPSAPKNTRTYPTAEVEKTRHDSSQSARQLKARSTATTISISLSTVSDVFTLPRNNLKSKTNTKKCRDNLNLSGLSSSTCNANSVNKLMKHVMMGNEMMKYPRSESFKMFKKSHWRYFWINPHCEMLCWSKTNPFIEKGRKNQVKSVKIKGMTIIKAPDALKNANLHNEVIVMQTTDKPIVLKAKSKKIHNIWVQAIKQINHKAIFDTKPGI", "function": "Involved in chromosome segregation. Facilitates nuclear oscillation during meiotic prophase I, the 'horsetail' phase, by acting as a dynein anchor. Essential for anchoring dhc1 to the cortex. Required for proper sliding of the microtubules along the cell cortex, which leads to the proper U-turn movement of the nucleus.", "AFDB_id": "AF-Q9Y7J9-F1-model_v4" }, { "swissprot_id": "P38937", "sequence": "METLSYSQIKKRKADFDEDISKRARQLPVGEQLPLSRLLQYSDKQQLFTILLQCVEKHPDLARDIRGILPAPSMDTCVETLRKLLINLNDSFPYGGDKRGDYAFNRIREKYMAVLHALNDMVPCYLPPYSTCFEKNITFLDAATNVVHELPEFHNPNHNVYKSQAYYELTGAWLVVLRQLEDRPVVPLLPLEELEEHNKTSQNRMEEALNYLKQLQKNEPLVHERSHTFQQTNPQNNFHRHTNSMNIGNDNGMGWHSMHQYI", "function": "Together with nucleoporin alm1, tethers the proteasome to the nuclear envelope. Involved in ubiquitin-mediated protein degradation and facilitates the degradation of nuclear proteins like mitotic cyclin and cut2. Required for normal progression of anaphase.", "AFDB_id": "AF-P38937-F1-model_v4" }, { "swissprot_id": "Q6CLM5", "sequence": "MDEYKSKLPRIPISKCKKIARTDPEYILTSQAAFAATAFTTELFIQMLAEETCSLAQIHKQTKTLRLNYEDLSTAIRNLDKFQFLSDVVPQTENLASLVRENKVRYTIVNPSPEIDIESEDEVDEANEPEVGEPEVDEAEVEAEVEAEAAEPETHTLDEPRPESSS", "function": "As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.", "AFDB_id": "AF-Q6CLM5-F1-model_v4" }, { "swissprot_id": "Q9XGR4", "sequence": "MEIDGGNDVQILDPELLQLPGLSPVSLKENPHIAEELFSQWLSLPETGRLVKSLIDDTKSSTPVSVSKNCTSLNVACGSALPSVFLNSGTPPLSPRGSPGSPRFSRQKTSPSLQSPLKSVREPKRQLIPQFYFQHGRPPAKELREQCISMVDQFFSNYIDGLHMDEFKSITKEVCKLPSFLSSVLFRKIDTSGTGIVTRDAFIKYWVDGHMLAMDVASQIYNILRQPGCKYLRQADFKPVLDELLTTHPGLEFLRNTPEFQERYAETVIYRIFYYINRSGTGCITLRELKRGNLITAMQQVDEEDDINKVIRYFSYEHFYVIYCRFWELDGDHDFLIDKENLIKYGNHALTYRIVDRIFSQVPRKFTSKVEGKMSYEDFAYFILAEEDKSSEPSLEYWFKCIDLDGDGVITPNEMQFFYEEQLHRMECITQEPVLFEDILCQIFDMIKPEKENCITLQDLKASKLSGNIFNILFNLNKFMAFETRDPFLIRQERENPTLTEWDRFAQREYVRLSMEEDVEEVSNGSADVWDEPLESPF", "function": "Regulatory subunit of type 2A protein phosphatase. Not involved in HMGR regulation in seedlings grown in standard medium, but negatively regulates root growth in response to salt.", "AFDB_id": "AF-Q9XGR4-F1-model_v4" }, { "swissprot_id": "Q8DL96", "sequence": "MDFGIGFLSNNVMLPILDFFYGIVPSYGLAIVALTLVVRFAVYPLSAGSIRNMRRMKVVQPIMQKRMQEIQQKYKDNPAEQQKAMAEVYREFGNPLAGCFPLLLQLPILFALFATLRGSPFADVNYQINLQIVPPDQPVLAQPFATKPQNIYVDEGVHFPIQAVVPSGTRIPVGQMVDLQFQTKEGKPFSELVAAYPNSHLQPKWQIIRGQERATIDREGHLQALQPGEVTVQGTIPGIAADKGFLFISALGHVGVIDQGELFITLPDGARQFNWGAIHWDILVMILGFGVSLYVNQLLSGQGSSNNPQQQTVNQLTPIIFSGMFLFFPLPAGVLLYMLIANIFQTVQTFILQREPLPENLQKLVEEQERAEAIKNRAPLPFEGKGAKGAKATKAKGNPSS", "function": "Probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid.", "AFDB_id": "AF-Q8DL96-F1-model_v4" }, { "swissprot_id": "P35883", "sequence": "MSEVLPLLYLHGLSSNDFTPALEQFLGSGAGLSASTITRLTAQWQDEARAFGARDLSATDYVYLWVDGIHLKVRLDQEKLCLLVMLGVRADGRKELVAITDGYRESAESWADLLRDCKRRGMTAPVLAIGDGALGFWKAVREVFPATKEQRCWFHKQANVLAALPKSAHPSALAAIKEIYNAEDIDKAQIAVKAFEADFGAKYPKAVAKITDDLDVLLEFYKYPAEHWIHLRTTNPIESTFATVRLRTKVTKGPGSRAAGLAMAYKLIDAAAARWRAVNAPHLVALVRAGAVFHKGRLLERPTDITPPTSPSDGGQHAGTEVA", "function": "Required for the transposition of the insertion element.", "AFDB_id": "AF-P35883-F1-model_v4" }, { "swissprot_id": "Q9PMD4", "sequence": "MLNNTLFFKQSEIHTISSYANRINDEVKSGDIGYYHLIDTSLNLIDESLQFIQDKEYVKNIVLVGMGGSSCGVKALRDMLFNEKSNQRELFILDNTSSHSFNKTLEKIKLEESLFLIISKTGSTIEVVSLFKLLIEHFKLDMQELKKYFVFITDKDSKLHQEGENLGIKCFFIPANVGGRFSILSAVGIVPLCFCGYNAKALLEGAKACFEDFFTHKKDEILQKAYHYCTHKNANINVLFSYSDAFKGFNEWYIQLIAESLGKKQGYKRIGLTPIALIGARDQHSFLQLIMDGPKNKTVTFLKIKDAQKAPIIPDIHFKFLDSLSNKVNLHELLNAQCDATMHALIAENLSVDVIELEKLDAWHAGYLMYYYELFTSTCGVMLGINTYDQPGVEVGKLILKNILNS", "function": "Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.", "AFDB_id": "AF-Q9PMD4-F1-model_v4" }, { "swissprot_id": "P10962", "sequence": "MSDEIVWQVINQSFCSHRIKAPNGQNFCRNEYNVTGLCTRQSCPLANSKYATVKCDNGKLYLYMKTPERAHTPAKLWERIKLSKNYTKALQQIDEHLLHWSKFFRHKCKQRFTKLTQVMITERRLALREEERHYVGVAPKVKRREQNRERKALVAAKIEKAIEKELMDRLKSGAYGDKPLNVDEKVWKKIMGQMEEENSQDEEEDWDEEEESDDGEVEYVADDGEGEYVDVDDLEKWLADSDREASSASESESDSESESDSDSDEENKNSAKRRKKGTSAKTKRPKVEIEYEEEHEVQNAEQEVAQ", "function": "Its role might be as part of the apparatus concerned with the nuclear events of the cell cycle.", "AFDB_id": "AF-P10962-F1-model_v4" }, { "swissprot_id": "Q95WY5", "sequence": "MRPLGALSLFALLATTVSGLAIREPDAKDWYQHATFYQIYPRSFLDSNGDGIGDLAGITSKMKYLADIGIDATWLSPPFKSPLKDFGYDVSDFYAIQPEYGNLTDFDKLVEEAHKNGIKLMLDFIPNHSSDQHEWFVKSVARDPEYSEFYVWKPPATGGGPPNNWISVFGGPAWTYNAARGEYYLHQFTPQQPDLNYRNPKLLAEMTKMLFFWLDRGVDGFRLDAINHMFEDEQFRDEPVSGWGQPGEYDSLDHIYTKDIPDVYNVVYNWRDQMDKYSAEKGRTIILMTEAYSSIEGTMLYYESADRKRQGAHMPFNFQLIYDFKKEQNAVGLKSSIDWWMNNMPARHTPSWVAGSHDHSRVASRVGLDRVDQVMTLMHTLPGTSITYYGEEVAMQDFKEAQQFDNRDPNRTPMQWDSSTSAGFSTNTNTWLRVHPDYARYNVDVMQKNPQSTFHHFQHLTKLRGHRTMQSGEYVHKTVGTKVYALLRELRGEDSFLTVLNMAGAEDTVDLGDFVNLPQKMRVEVAQPNSKSKAGNEVDISKLTLGPYDSVVLRATVSSAAAINLSIGLLLAIMARYIFV", "function": "(Microbial infection) Serves as the larval receptor for Lysinibacillus sphaericus BinB toxin (Ref.2).", "AFDB_id": "AF-Q95WY5-F1-model_v4" }, { "swissprot_id": "T2KM23", "sequence": "MKNKKRLCHILKYIITCFLFGVIFIIPIQAQIVLQTDFTDSENARQNIDYHFNVFNRITPLNGVKIKTPLGKPRVCIVRPLGGIVKNGKPDISKDSYKWDKKSKTFYTDFTVLKNQIDGVINSGYAIHQIVLDNPSWAFQRNKNGELVADSLKVSTYGNAEPPKDYNAWSNYLKDVLKFLVNTYGEESMLKIQFNIGREIGTPSHWSGSKEAFFEFYKISSSAIREVLPTAKVGTHFLWGSSKNAWGTDFIKWSKANNVHYDFIGVSFYPFYNKPDRTLFKEVYAKDFAVIKDIPEWHKNAKLEMHEYALIKSLNKAGNAFENAPKAQQNSFIVGLMKMFYEHNMQNVFQWGQGTNFEAAQEALFSIQGQTYYTSTKNGKPLLETNDVDAIFIKDVSNNIYNIMAYNYNANPNATTDEHLNLKAKLDVPPGTKVKVRFALYNKEKDTMSWSEWKEEATQGNEKSKSVISLNAELPVFSFLKYEVKVQ", "function": "Alpha-rhamnosidase involved in ulvan degradation. Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall. It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable). Endo-acting alpha-1,4-L-rhamnosidase cleaves rhamnose sections interspersed between xylose residues within the polymer, degrading larger oligomers with consecutive Xyl-Rha3S units that are resistant to the ulvan lyases and producing dimers Xyl-Rha3S and Xyl2S-Rha3S as the smallest products.", "AFDB_id": "AF-T2KM23-F1-model_v4" }, { "swissprot_id": "P02895", "sequence": "MRLSKVSDIKSTGVSNYKNFNSKNSSKYSLMEVSKKNEKKNSLGAFHSKKILLIFGIIYVVLLNAYICGDKYEKAVDYGFRESRILAEGEDTCARKEKTTLRKSKQKTSTRTVATQTKKDEENKSVVTEEQKVESDSEKQKRTKKVVKKQINIGDTENQKEGKNVKKVIKKEKKKEESGKPEENKHANEASKKKEPKASKVSQKPSTSTRSNNEVKIRAASNQETLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYASDPEYRKHLEIFYKILTNTDPNDDVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEVFHKILTNTDPNDEVERRNADNKELTSSDPEGQIMREYAADPEYRKHLEIFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEELTSSDPEGQIMREYAADPEYRKHLEIFHKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFYKILTNTDPNDEVERRNADNKEDLTSADPEGQIMREYASDPEYRKHLEIFYKILTNTDPNDDVERRNADNKEDLTSADPEGQIMREYAADPEYRKHLEIFHKILTNTDPNDEVERQNADNNEA", "function": "Involved in merozoite invasion of host erythrocytes.", "AFDB_id": "AF-P02895-F1-model_v4" }, { "swissprot_id": "Q52VH2", "sequence": "MTSTQRLWSGALPLLTALIVSIAATASLAGPRARDLGVPFEGTPGALNAITDVAGVEVGHTTVISGDGAMVIGKGPYRTGVTIIHPLGKTSLDGVAAGRAVINGTGEWTGMHLVDEVGQFLGPIALTGTGNVGLVHQSMMDWSVGKVPEEALFSRLLPVVAETLDNRLNDVFGHGLTRDHVFAALDGAKGGPVAEGNVGGGTGMIAYTFKGGIGTSSRVVSAGDTRYTVGVLVQANHGDRNDLRIAGVQIGKEIKGAWPEVNGIVAAGPDAGKPQDKNSLLIVIATDAPLMPHQLERMARRAALGVGRNGSTAGALSGEFALAFSTSHVIPLGGKPRLPAIINDTDSETMNALFRGVVQATEEALVNQLVASETMTGANNAKVYGIPHDQLARIMKARFPRR", "function": "Beta-aminopeptidase that can cleave synthetic beta-peptides which consist of backbone-elongated beta-amino acid residues that are not processed by common proteolytic enzymes. Can cleave the beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu. Requires a beta-amino acid at the N-terminus of peptide substrates and cleaves the peptide bond between the N-terminal beta-amino acid and the amino acid at the second position of tripeptidic substrates of the general structure H-betahXaa-Ile-betahTyr-OH according to the following preferences with regard to the side chain of the N-terminal beta-amino acid: aliphatic and aromatic > OH-containing > hydrogen, basic and polar.", "AFDB_id": "AF-Q52VH2-F1-model_v4" }, { "swissprot_id": "P14417", "sequence": "PNVRWEYCNLTQCSDAEGTAVAPPNVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNGGLIRNYCRNPDPVAAPYCYTMDPNVRWEYCNLTQCSDAEGIAVTPLTVTPVPSLEAPSKQAPTEQRPGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNGGLIRNYCRNPDPVAAPYCYTMDPNVRWEYCNLTQCSDAEGTAVAPPNVTPVPSLEAPSEQAPTEQRSGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMKPHSHSRTPENYPNGGLIRNYCRNPDPVAAPYCYTMDPNVRWEYCNLTQCSDAEGTAVAPPNVTPVPSLEAPSEQAPTEQRLGVQECYHSNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNAGLVKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEGTAVMPPNIIPVPSLEAFLEQEPTEETPGVQECYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPKNYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLETLTVVPDPSTQASSEEAPTEQSPEVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPDGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVTESSVLATSMAVSEQAPMEQSPGVQDCYHGDGQSYRGSFSTTVTGRICQSWSSMTPHWHQRTIEYYPNGGLTKNYCRNPDAEIRPWCYTMDPRVRWEYCNLTQCVVMESSVLATPMVVPVPSREVPSEEAPTENSPGVQDCYQGDGQSYRGTFSTTITGRTCQSWLSMTPHRHRRIPLRYPNAGLTRNYCRNRDAEIRPWCYTMDPSVRWEYCNLTQCPVTESSVLTTPTVVPVPSTEAPSEQAPPEKSPVVQDCYHGDGQSYRGTSSTTVTGRNCQSWSSMIPHWHQRTPENYPNAGLTRNYCRNPDSGKHPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVQQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHQHKRTPENHPNDDLTMNYCRNPDADTGPWCFTMDPSVRREYCNLTRCSDTEGTVVTPPTVIPVPSLEAPSEQASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAACCLETFSRPSFYKVILGAHQEVNLESHVQEIEVSRLFLEPIGADIALLKLSRPAIITDKVIPACLPSPNYVITAWTECYITGWGETQGTFGAGLLKEAQLHVIENTVCNHYEFLNGRVKSTELCAGHLAGGTDRCQGDNGGPVVCFDKDKYILRGITSWGPGCACPNKPGVYVRVSSFVTWIEGVMRNN", "function": "Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.", "AFDB_id": "AF-P14417-F1-model_v4" }, { "swissprot_id": "B1Y6R5", "sequence": "MSFLAIDIGNTRLKWGLYDAAKPGARLLAHGAVFLETIEQLAEQDWARLPHPTAMLGCAVAGDAVRRRTEEQLELWDLTPHWVVSQPVGGGIVNGYDHPSRLGSDRWVAMVGARERILEQTGPGARPVPAIVVMVGTAVTVDAVDPDGCFIGGLILPGFGLMLKALEMGTAGLRVPTGDVCEFPTNTSDALMSGGACGIAGAIERMHRQLQQRCGVAPRILMSGGAATKLAQIMALPVEVVDTLVFDGLLRLASDRVAAGLA", "function": "Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.", "AFDB_id": "AF-B1Y6R5-F1-model_v4" }, { "swissprot_id": "P16426", "sequence": "MSPERRPADIRRATEADMPAVCTIVNHYIETSTVNFRTEPQEPQEWTDDLVRLRERYPWLVAEVDGEVAGIAYAGPWKARNAYDWTAESTVYVSPRHQRTGLGSTLYTHLLKSLEAQGFKSVVAVIGLPNDPSVRMHEALGYAPRGMLRAAGFKHGNWHDVGFWQLDFSLPVPPRPVLPVTEI", "function": "Inactivates phosphinothricin (PPT) by transfer of an acetyl group from acetyl CoA. Can also acetylate demethylphosphinothricin but not PTT or glutamate. This enzyme is an effector of phosphinothricin tripeptide (PTT or bialaphos) resistance.", "AFDB_id": "AF-P16426-F1-model_v4" }, { "swissprot_id": "P0C589", "sequence": "MKTMASFVLVLVAAFALPAAFASLETKDVITRAAYEKLVESGAIQGITMTKTIISNPILEEALVAHFNRKLGGGTIFDCGESCFLGTCYTKGCSCGEWKLCYGTNSLPESNNEKAMVASLEKDVITRAAYENLVNSGAIQGITMTKTIISNPILEEALVSHFNRKLGGGTIFDCGESCFLGTCYTKGCSCGEWKLCYGENSLAI", "function": "Probably participates in a plant defense mechanism. Has a weak hemolytic activity.", "AFDB_id": "AF-P0C589-F1-model_v4" }, { "swissprot_id": "P33293", "sequence": "MSLYEYNDPIINKDLAQADPVMGQNRTFPTLEAWYDVINDYEFQSRCPIILKNSHKTKHFTFACHLKSCPFKILLSHQGPVSVQNGDGSPGVGVGDEHGHHHHHNMHAHHHHHHQNGHTNGHGNSGDDVSEQEAQQDDEDDDAAVTAAIAAAVAAVADSQETIKGPFAVTKIEPYHNHPLESNLSLQRFVLTKIPKILQVDLKFDAILESLCNDEDNTVAKFRVAQYVEESGIIDIIKQRYGLTDAEMDKKMLSNIARRVTTDKARFVLKRKKEGVYMLPNGHQISGADQHQHQLQHQHQHQHQHQHQHQHQHQSQDQHQNQHQQHVGNDNHVYQDRIHSQSDQDEAGVHNLDDNNVRVAAAAAAAAAAALQSRDSHVSEELKLNCGTGQDEDGIEDDNHSSKRQLHRSDRDRVAEALKMATRDILSNQNVDSDVNVDVDLVTGHKQLSPHDDMAEQLRLLSSHLKEVEAEENVSDSNLKKDDVQDENIQPELRGQ", "function": "General regulatory factor (GRF) that contributes to transcriptional activation of a large number of genes, as well as to DNA replication, silencing and telomere structure. Involved in the transcription activation of a subset of ribosomal protein genes. Binds the ARS-elements found in many promoters. Binds to the sequence 5'-TCN(7)ACG-3'.", "AFDB_id": "AF-P33293-F1-model_v4" }, { "swissprot_id": "F4NYQ2", "sequence": "MTMDGVFPLTATVDYCDIFLTHDSASVRKAHNTGWKHKMQVEHYYNAEVDPAKIQSVIDNVTKAYIDAGLPGFPELIAVGVNGQRGQPVGGPPRPPQPFHNGGRPGPPGRPPMGMFPPQRPMMPPPHMRPGLSQMPPGMRPPGPPPHGFMNGSMPPPLGTPVMENGPVAGQQSQAPVAPRIHPDRLRLAGNSIKSKLVIESIYCFYPFGCLDSQIATHTFLYHCANDS", "function": "Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.", "AFDB_id": "AF-F4NYQ2-F1-model_v4" }, { "swissprot_id": "Q801X7", "sequence": "MDFVEVKNLIMKSGMELKVNGVFNANPERFSINVGHSTEEIAVHVDVRFSYLSDKRQLIINHKTGDAWQEEQRDARFPFTAGQAFQVSVVFNFDTFDIYLPDGQVAHFTNHLGAQEYKYIFFVGDATVKNISVNVADKPTKR", "function": "Involved in host defense at the body surface. Causes agglutination of the Gram-positive bacterium S.difficile. Possesses calcium-independent hemagglutinating activity.", "AFDB_id": "AF-Q801X7-F1-model_v4" }, { "swissprot_id": "Q52985", "sequence": "MTAQSQIYSGAFADPVFEAQSVFRSLMDCFARPGIIGRLSTAAAPPAPLGEASGAVALTLCDHDTPVWLSPALSKSSAPKWIAFHTGAGVTDTKDEPRFAFFEKGAAVPGFDQFALGTQEYPDRSTTLVVEVEALEGGQPLIGRGPGIKNGIVIAPKGLPDVFLDLWAANRAIFPRGIDLVLTAREAVLCLPRTTKLERE", "function": "Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.", "AFDB_id": "AF-Q52985-F1-model_v4" }, { "swissprot_id": "Q66JG1", "sequence": "MPPKRATRGRRNVELSSEEEEEQEEVSPGKRKRDIEKNGEARLKKPSKKRSGQQCASDVPCSSKESDCGTNLTNKGDKQRSIVHYLYRSTLGGNVRAKYLQTPFLRSLASYILYRTNSPFDRRVTTLEWHPTHPNTVAVGSKGGDIILWDYEELNNTLIPGIGAGGCITGMKFDPFNPNQLYTSSVAGSTVLQDFSGRNIQTFTNTEDWAMWYCSLDVSAERQCVVTGDNVGNVVLLETCGKEIWKLRLHKKKVTHVEFNPRCDWLLASASVDQTVKLWDLRNIKDKSSYLYTLPHARGVNSAYFSPWDGAKLLTTDQHSEIRVYSACDWAKPQHIIPHPHRQFQHLTAIKATWHPRYDLIVVGRYPDPLFPGYMSDELRTVDVFDGQKGNIVCQLYDPYASGIVSLNKFNPMGDLLASGMGFNILIWSREILLMMKQEEMMKALREKGVSVGRKELPNSRLPHSSAPREKPGNKGSTTESSKTRTVRESSKRGKHKDPGK", "function": "Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.", "AFDB_id": "AF-Q66JG1-F1-model_v4" }, { "swissprot_id": "P75539", "sequence": "MVSNKLEQTFKFANDKNIERAERVLMQALVQDAVGVDLILTKLEPKDFFGFPFNFIFQTAQENYSEGNKLFGSALLEAVKFKLDTDSKTQREIEGLFEDVLLKGLPFLERDIKVFVDVVKKASIFRQLKQFAKKVEKEEFKVKDDRFEGYLQAIQNDFTKIIHSAFVSIPGLSYDEIVREEEELIPKVYRGELTVKGLKSGFYPLDQLTSGWKEGELIVVAARPGRGKTALLINFLQGAVNDSEKFDKNKDVLLFFSLEMRNREIYQRHLMLESQVNYTLTSRQRLANVYDDLIKASEVLRDLPIKIFDYSTITLDEIRAQITEVSKTNNVKLVVIDYLQLVNAFKNSYNISRQQEVTMISKSLKSFAKEFNVPIIAAAQLSRRIEERKDSRPILSDLRESGSIEQDADMVLFIHRVKDEDSENQEAIGHNNIFQVELILEKNRSGPTGKVQFDFQSDVSTFRVREYNPDGYS", "function": "Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.", "AFDB_id": "AF-P75539-F1-model_v4" }, { "swissprot_id": "P40545", "sequence": "MTKFIGCIDLHNGEVKQIVGGTLTSKKEDVPKTNFVSQHPSSYYAKLYKDRDVQGCHVIKLGPNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWLFTKEGHFQLKRLERLTELCGKDRIVVDLSCRKTQDGRWIVAMNKWQTLTDLELNADTFRELRKYTNEFLIHAADVEGLCGGIDELLVSKLFEWTKDYDDLKIVYAGGAKSVDDLKLVDELSHGKVDLTFGSSLDIFGGNLVKFEDCCRWNEKQG", "function": "Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR.", "AFDB_id": "AF-P40545-F1-model_v4" }, { "swissprot_id": "Q75HB1", "sequence": "MATPRTLVPILPPVAALLLLLVAASSIPILAAAQPADACGGAPDQAAADGACHDVPRALRLKLIAIPTILVSSVVGVCLPLLSRSVPALRPDGGLFAVVKAFASGVILATGYMHVLPDAFNNLTSPCLPRKPWSEFPFAAFVAMLAAVSTLMADSLMLTYYNRSKPRPSSGGDVAAVADHGESPDQGHRHGHGHGHGHGMAVAKPDDVEATQVQLRRNRVVVQVLEIGIVVHSVVIGLGMGASQNVCTIRPLVAAMCFHQMFEGMGLGGCILQAEYGRRMRSVLVFFFSTTTPFGIALGLALTRVYRDNSPTALIVVGLLNAASAGLLHYMALVELLAADFMGPKLQGNVRLQLAAFLAVLLGAGGMSVMAKWA", "function": "Iron transporter involved in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. May also transport other divalent cations.", "AFDB_id": "AF-Q75HB1-F1-model_v4" }, { "swissprot_id": "P22855", "sequence": "MSSEDIIYDPQFKPVQGIYENRLRQFIDTGGDYHDLNLPKFYDKKRISLDHDHVKVWWYQVSFERGSSPVSPDKRPSWKSIIERDKKGELEFREANINQPFGPSWSTTWFKVKISLPEDWVKSNEQLLFQWDCSNEGIVIDPKTLIPVTAFSGGERTEYVLPKTSDGKHFFYIEAGNNGMFGCGAGSTINPPDDNRFFHLRKADIVWPDLDARALYIDFWMLGDAARELPGDSWQKHQARQLGNAVMNLFDPNDRSSVRKCRELLQREYFDSFLESSKVYEQGESQVLTNVYGIGNCHIDTAWLWPFAETRRKIVRSWSSQCTLMDRFPEYKFVASQAQQFKWLLEDHPEFFNKVLIPKIQQSQFFAVGGTWVENDTNIPSGESLARQFFFGQRFFLKHFGLKSKIFWLPDTFGYSSQMPQLCRLSGIDKFLTQKLSWNNINSFPHSTFNWAGIDGSQLLTHMPPGNTYTADSHFGDVLRTAKQNKTPEYYGSGLMLYGKGDGGGGPTEEMLQKMRRIRSMNNRNGNVIPKLQVGITVDEFYDDILKRTNQGHDLPTWSGELYFEFHRGTYTSQAQTKKLMRLSEIKLHDLEWIAAKTSVLYPDSYKYPSKQINELWENVLLCQFHDVLPGSCIEMVYKYEAVPMLHNVVKECTSLIDKTVQFLQSQSKADLVEMRTLTWSKPEKVSEECSLNGSYTSSVTGYDDYIVLANGKLKVIICKKTGVITSITDETLGVEYLDTEHGRNKLGANQFVIYDDKPLGWQAWDTELYSVNQYKYVTKPKKVQVSCNTKEKCAVEVIFQISEKCKIKSVISLNATAVTDAKLSKVDISTTVENWDARNKFLKVEFPVNIRNDFASYETQFGITKRPTHYNTSWDVAKFEVCHHKFADYSEYSKGVSILNDCKYGFSTHGNLMRLSLLRSPKAPDAHADMGTHEIKYAIYPHRGALSSDTVKLAHEFNYCFKYKLPKDIGMNFDDIISISGDENVILSNIKRGEDDSAVKSNYSLNPRDEQSIVVRVYESLGGESFASLNTTLNLKRIEKVDNLEMKVYKSLTATRDESNHAINRIPIKLRPFEIASFRLYF", "function": "Degrades free oligosaccharides in the vacuole.", "AFDB_id": "AF-P22855-F1-model_v4" }, { "swissprot_id": "Q6FJL1", "sequence": "MQSVNIVSTNYSRYGVSVYDRLYRKDKNVSAKHRPSSTGVYGHDASTVDHASRSNNNLNLTRSTSAISESDDVATISTNNSRRSVIKRKYKSLITASSKKLITKLYEHGSNSDSFSIFSHKTSQSHHPAQRLGTEEDLIINDLFKRKEISDLPDEVLRNILSNVKDDQRTLVNCLYVNKAFYNATKPTLYERPKFTSTYRVAQFVTSIRTNPQNGLYVRELDLSKLKNGSLNGKSTSNTGVVADSPDVDEYNPMRTRTGSVTSFTSVTSTANSNTALSITTNNKDVALAGWRDWRYRHDPLYSSPVLNSYNAKRTVSRAPSIKSSHSSSSLTLFPGLKSKESFAQLSEGKSSDNGNNGKRQRSNSSVSSITNSLMSSLYNGSHISLNTTLSGSDNNSSKTQSKGKSSSSPGNPNDSSGEQDSIISSSSQIDTNTFGMTSSKSTSSTSNWFRMKLHGNGTRKLRLRSNKAISSKKDEQQNEESAQTAQKIETPIIKRTEPFSTPHPYTNKFLLKYAQYKDLPLGYILHILDHCPYLYILDLSNLTLCTDFEIIEGRRYKGRKQRFGSSRALPVVQESVISTDVPNDLDVIYLTDSSKTYEYYDRLRNTNKHKRSSSSNNLWSIPNQGWSDAPAPIGSHKNDLRRTHSQTIGRSNVELRKLNASEIFEHIATNQKSAYNTHLRVYMKNVLWCTQDMVKSFVLENFDQQAENLGEDKSSEMFIHDMNFSFENSGLNRNFVWTCEGNLQEFIAMVVLDEVNRKDDLEIENLFNIKAERILTPTNGPERAPEVHYISNVFTVSYGFQSNKKREMKFRVTILKTDTPMYFSIKKLADDYTSVVIKLQTNKNVALHGSETADIITTDQGSVLPEDVPEDNNADDTNNGENTIAQPFSNDPKERIERITQEIVARLKDLRGSDLRRNIGENNYVRERFLL", "function": "F-box protein probably involved in ubiquitin conjugation pathway.", "AFDB_id": "AF-Q6FJL1-F1-model_v4" }, { "swissprot_id": "O80875", "sequence": "MPTPVTTARQCLTEETARALDDAVSVARRRSHAQTTSLHAVSGLLTMPSSILREVCISRAAHNTPYSSRLQFRALELCVGVSLDRLPSSKSTPTTTVEEDPPVSNSLMAAIKRSQATQRRHPETYHLHQIHGNNNTETTSVLKVELKYFILSILDDPIVSRVFGEAGFRSTDIKLDVLHPPVTSQFSSRFTSRSRIPPLFLCNLPESDSGRVRFGFPFGDLDENCRRIGEVLARKDKKNPLLVGVCGVEALKTFTDSINRGKFGFLPLEISGLSVVSIKISEVLVDGSRIDIKFDDLGRLKSGMVLNLGELKVLASDVFSVDVIEKFVLKLADLLKLHREKLWFIGSVSSNETYLKLIERFPTIDKDWNLHLLPITSSSQGLYPKSSLMGSFVPFGGFFSSTSDFRIPSSSSMNQTLPRCHLCNEKYEQEVTAFAKSGSMIDDQCSEKLPSWLRNVEHEHEKGNLGKVKDDPNVLASRIPALQKKWDDICQRIHQTPAFPKLSFQPVRPQFPLQLGSSSQTKMSLGSPTEKIVCTRTSESFQGMVALPQNPPHQPGLSVKISKPKHTEDLSSSTTNSPLSFVTTDLGLGTIYASKNQEPSTPVSVERRDFEVIKEKQLLSASRYCKDFKSLRELLSRKVGFQNEAVNAISEIVCGYRDESRRRNNHVATTSNVWLALLGPDKAGKKKVALALAEVFCGGQDNFICVDFKSQDSLDDRFRGKTVVDYIAGEVARRADSVVFIENVEKAEFPDQIRLSEAMRTGKLRDSHGREISMKNVIVVATISGSDKASDCHVLEEPVKYSEERVLNAKNWTLQIKLADTSNVNKNGPNKRRQEEAETEVTELRALKSQRSFLDLNLPVDEIEANEDEAYTMSENTEAWLEDFVEQVDGKVTFKLIDFDELAKNIKRNILSLFHLSFGPETHLEIENDVILKILAALRWSSDEEKTFDQWLQTVLAPSFAKARQKCVPAAPFSVKLVASRESPAEEETTGIQQFPARVEVI", "function": "Probable component of a transcriptional corepressor complex involved in branching control. Regulates cotyledon expansion and lateral root growth, but not germination or hypocotyl elongation. Promotes auxin transport and PIN1 accumulation in the stem and represses BRC1/TCP18 expression in axillary buds.", "AFDB_id": "AF-O80875-F1-model_v4" }, { "swissprot_id": "Q12366", "sequence": "MSKDNRLASILLQPVASSSGNCTEFHDSKLHTLQEELNFLPLEGVASNVCPPMFRGHKNYVFVLYCLNQVDLVTNLQDSTKRYYPLQIFKDCQLSSLVQKDFSHYFQLSRQKEGEDRNDSDTTLVNVVNSGVSRHRSQLLKMCIIPRICSFDKSNSKTYKLIQEYVNRFETVLTKFGPEKDFTKVYANWSKLIESFNELILHDLLVKWQQWSELTQPNATVHQNIPNVLRELVIKLTQRYFTFQPSYSCSIDEFTTILLNKNALSLLDVFRKPRKYKLNFGLWLDCQNGILIFTNGIVQMADEITSERVKSFVRPAHLLVLEDHSNDEAVKKLMFFTFSAILQCFTDEILNC", "function": "Required for telomeric clustering (bouquet stage) during meiosis 1 prophase, formation and efficient homolog pairing, meiosis 1 disjunction, and telomere deletion during meiosis. Promotes also meiotic recombination.", "AFDB_id": "AF-Q12366-F1-model_v4" }, { "swissprot_id": "Q9CN97", "sequence": "MLSLFRIIIHVCCLGPVAWLAWVLLSGDESQLGADPIKEIQHFLGFSALTILLIMFILGKVFYLLKQPQLQVLRRALGLWAWFYVVLHVYAYLALELGYDFSLFVQELVNRGYLIIGAIAFLILTLMALSSWSYLKLKMGKWWFYLHQLGYYALLLGAIHYVWSVKNVTFSSMLYLILSIMILCDALYGLFIKRKGRSTSAHTGKD", "function": "Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.", "AFDB_id": "AF-Q9CN97-F1-model_v4" }, { "swissprot_id": "P32675", "sequence": "MTSSAGQRISCNVVETRRDDVARIFNIQRYSLNDGEGIRTVVFFKGCPHLCPWCANPESISGKIQTVRREAKCLHCAKCLRDADECPSGAFERIGRDISLDALEREVMKDDIFFRTSGGGVTLSGGEVLMQAEFATRFLQRLRLWGVSCAIETAGDAPASKLLPLAKLCDEVLFDLKIMDATQARDVVKMNLPRVLENLRLLVSEGVNVIPRLPLIPGFTLSRENMQQALDVLIPLNIRQIHLLPFHQYGEPKYRLLGKTWSMKEVPAPSSADVATMREMAERAGLQVTVGG", "function": "Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.", "AFDB_id": "AF-P32675-F1-model_v4" }, { "swissprot_id": "P45992", "sequence": "MQKTPKKLTALCHQQSTASCSGSNYSGSNYSGSKCFRLHRLALLACIVALPAYAVDGRVTFQGEIVSDGTCKIETDSKNRTVTLPTVGKANLSLAGQTAAPVPFSITLKECNAADAKKANLLFSGAVTKGQLYLSNAASSGKANNVGIQIVKADGTGSPINVDGSQANSEKAPDTGKEQNSTVIQPRFDYFAHYYATGAATAGEVEATATFQVQYN", "function": "May be a minor structural protein required for pilus biogenesis.", "AFDB_id": "AF-P45992-F1-model_v4" }, { "swissprot_id": "Q9FMH4", "sequence": "MDNKFYVNTNGERNIWSTAAEENMTTAASSSQSQPPQMQSSKFHQPENHIHINDGFSSGAFDLQTLESSFRGLSFADSNVHQNGNPILPAHQYNQVFNGGGGSYGDGYLFPPSGSYHHYELKDLQRFNQNQQRLSYQNDYVNQSYRYDTIGGGNGMLNNSFLNGVPCASRNNVSDYYTNIFGYGVNNSWRSNEGCTYNQDQAASSMENGRGSYFSIATDRVWSKELEKTIFVGTKETIDMIFDGLIVGICELMVDPFGNDVVKLLIGKCSSEQIILIVDVVTRHISKFVNICFNPIGTLAIQVLLTSIHERANNQIPRIMDAISSVALQLTRNTNAKYVILACFRMFTSSQCRRLLEVVSQHCYQIAIDQNGCCLLQQCFDKERVPNHEIRQRLISEVIEHALKLCLNCHGNYVVQYVVELDNQHETDLLVNKLLRNYAHLARNKYGSHVVQKLLKLRGIDSKLIVVDLLRGIDTLLLDPFGNYVIQTAWFVSKEDVRQMLRYYIERNIRLMRCNKFGNKILEKLNI", "function": "Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.", "AFDB_id": "AF-Q9FMH4-F1-model_v4" }, { "swissprot_id": "O43240", "sequence": "MRAPHLHLSAASGARALAKLLPLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLLLLQGEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN", "function": "Has a tumor-suppressor role for NES1 in breast and prostate cancer.", "AFDB_id": "AF-O43240-F1-model_v4" }, { "swissprot_id": "O66612", "sequence": "MDAIQEVKRIIPEVQKYVNQRMEEFERLGREGWTHFDFRPFLDIDYDAGLFSELSFCILTANSSATLGIKIQAHLGEEGFLNKTKEELEEVFRKFGHRYAGQRAERIVEAREKFPKVKSLIEKEKNSKVIRELLADPKSPYKIKGFGYKEASHFLRNIGFKDLAIIDRHISRFLMEKGLLRQVKSITPKVYLEAEKALESLAKELGLSLGELDLYIFYIKTKKVLK", "function": "Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).", "AFDB_id": "AF-O66612-F1-model_v4" }, { "swissprot_id": "Q8NFW1", "sequence": "MAGLRGNAVAGLLWMLLLWSGGGGCQAQRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPTTAFELGLFGSQEEVKAAARRLAYHGGNTNTGDALRYITARSFSPHAGGRPRDRAYKQVAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVSDFNAIDKIRGKLRRRLCENVLCPSVRVEGDRFKHTNGGTKEITGFDLMDLFSVKEILGKRENGAQSSYVRMGSFPVVQSTEDVFPQGLPDEYAFVTTFRFRKTSRKEDWYIWQVIDQYSIPQVSIRLDGENKAVEYNAVGAMKDAVRVVFRGSRVNDLFDRDWHKMALSIQAQNVSLHIDCALVQTLPIEERENIDIQGKTVIGKRLYDSVPIDFDLQRIVIYCDSRHAELETCCDIPSGPCQVTVVTEPPPPPPPQRPPTPGSEQIGFLKTINCSCPAGEKGEMGVAGPMGLPGPKGDIGAIGPVGAPGPKGEKGDVGIGPFGQGEKGEKGSLGLPGPPGRDGSKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPPGRVGAPGLQGERGEKGTRGEKGERGLDGFPGKPGDTGQQGRPGPSGVAGPQGEKGDVGPAGPPGVPGSVVQQEGLKGEQGAPGPRGHQGAPGPPGARGPIGPEGRDGPPGLQGLRGKKGDMGPPGIPGLLGLQGPPGPPGVPGPPGPGGSPGLPGEIGFPGKPGPPGPTGPPGKDGPNGPPGPPGTKGEPGERGEDGLPGKPGLRGEIGEQGLAGRPGEKGEAGLPGAPGFPGVRGEKGDQGEKGELGLPGLKGDRGEKGEAGPAGPPGLPGTTSLFTPHPRMPGEQGPKGEKGDPGLPGEPGLQGRPGELGPQGPTGPPGAKGQEGAHGAPGAAGNPGAPGHVGAPGPSGPPGSVGAPGLRGTPGKDGERGEKGAAGEEGSPGPVGPRGDPGAPGLPGPPGKGKDGEPGLRGSPGLPGPLGTKAACGKVRGSENCALGGQCVKGDRGAPGIPGSPGSRGDPGIGVAGPPGPSGPPGDKGSPGSRGLPGFPGPQGPAGRDGAPGNPGERGPPGKPGLSSLLSPGDINLLAKDVCNDCPPGPPGLPGLPGFKGDKGVPGKPGREGTEGKKGEAGPPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFMGPPGNPGPPGADGIAGAAGPPGIQGSPGKEGPPGPQGPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEPGLPGPEGARGPPGFKGHTGDSGAPGPRGESGAMGLPGQEGLPGKDGDTGPTGPQGPQGPRGPPGKNGSPGSPGEPGPSGTPGQKGSKGENGSPGLPGFLGPRGPPGEPGEKGVPGKEGVPGKPGEPGFKGERGDPGIKGDKGPPGGKGQPGDPGIPGHKGHTGLMGPQGLPGENGPVGPPGPPGQPGFPGLRGESPSMETLRRLIQEELGKQLETRLAYLLAQMPPAYMKSSQGRPGPPGPPGKDGLPGRAGPMGEPGRPGQGGLEGPSGPIGPKGERGAKGDPGAPGVGLRGEMGPPGIPGQPGEPGYAKDGLPGIPGPQGETGPAGHPGLPGPPGPPGQCDPSQCAYFASLAARPGNVKGP", "function": "Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts.", "AFDB_id": "AF-Q8NFW1-F1-model_v4" }, { "swissprot_id": "Q03720", "sequence": "MASGLIDTNFSSTLANGMSGCDQSTVESLADDPTDSPFDADDCLKVRKYWCFLLSSIFTFLAGLLVVLLWRAFAFVCCRKEPDLGPNDPKQKEQKASRNKQEFEGTFMTEAKDWAGELISGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQIDLAFNIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNVLKTSSSIRLAQLVSIFISVWLTAAGIIHLLENSGDPLDFNNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFFLLVGLAMFASSIPEIIELVGSGNKYGGELKREHGKRHIVVCGHITYESVSHFLKDFLHEDREDVDVEVVFLHRKPPDLELEGLFKRHFTTVEFFQGTIMNPIDLQRVKVHEADACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPDMQSWTNDYLRGTGMEMYTETLSPTFIGIPFAQATELCFSKLKLLLLAIEIKGAEEGADSKISINPRGAKIQANTQGFFIAQSADEVKRAWFYCKACHEDIKDETLIKKCKCKNLTVQPRSKFDDLDEHHPAPTFTPPELPKRVHVRGSVSGDITRDREDTNLLNRNVRRPNGTGNGTGGMHHMNNTAAAAAAAAAAGKQVNKVKPTVNVSRQVEGQVISPSQYNRPTSRSSGTGTQNQNGGVSLPAGIADDQSKDFDFEKTEMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSQRGPEFDNLSATAGSPIVLQRRGSVYGANVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTVESLSNRDRCRVGQISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYRFRDTSSSCDASSKRYVITNPPDDFSLLPTDQVFVLMQFDPGLEYKPPAVRAPAGGRGTNTQGSGVGGGGSNKDDNS", "function": "Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob1 and 14-3-3-zeta decreases its activity.", "AFDB_id": "AF-Q03720-F1-model_v4" }, { "swissprot_id": "Q5AGD1", "sequence": "MSVSAIRIPANGSSAKAAVIFLHGLGDSGDGWSWLPQLVSQSKLINDPINYVFPNAPKIPVTINNGFAMPAWFDIYELGNPHAKQDVTGFFKSCEVLKEFILEQHNKFNIPLEKIIIGGFSQGAAISLATLALLDTKIGGCVALSGFCPVRNEITDRYNKNPGVNFDTPIFQGHGTVDPVINYDYGKQTSELYKQLGFKNLKFNTYEGVAHSASEEELADVIKFIKNIVEK", "function": "Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.", "AFDB_id": "AF-Q5AGD1-F1-model_v4" }, { "swissprot_id": "Q568V3", "sequence": "MATDWKQKCDSEWQLGAHGVPMPDTVDWKSVFETKPFERNLLQNPSPYGVNHTVPPPEPHRSGIPPPSDRPPQLEPEGNFSGWKTNTEVLPYDTSGIPPGVVICQLPQHRWFTLEQCVDLKAAGLWDQLLDDFQPEIVIEDWYEESQLHKCIYQLDVKLLGADGETVIKQHTYNPEEDLECYSHTWKKVSHVFSKYAPGVRYIHFLHRLKNQFMVEFFNTKVTDSSVIVKASKPSVK", "function": "May promote cell proliferation.", "AFDB_id": "AF-Q568V3-F1-model_v4" }, { "swissprot_id": "O94487", "sequence": "MDLLGLKELDNNKLVSKAKENGVEFSDLFLLSSGYLRDRENASASVSSKNERMVLNEERQNCWTKRNDPKGLTYYQLLKPSEVEILSRPETRRKRMACQVFFLNYYISTIEYHKLRKERLEEFTACTSSLKQSKQKRLWKEHCGRERAFLRKKRTKIQCSHFDLLVKLGQGGYGSVWLAKKRNTHELLAMKMMKKSTLQQLNEVKHILNERDILTNTNSEWLVKLYYAFQDKEKVYLAMEYVPGGDFRTFLTTKGLLHENQTRFYLAEMVAAISAVHKLGYMHRDLKPENFLIDQKGHIKLSDFGLSTAIVTSNQVNRLQHALVSAVNPQRPYLTQKQRRNIYKALLEKNENKVNSVVGSPEYMAPEVVYGKKYDRTVDYWSLGCICYECLVGYPPFSGSTLQETWTNLYYWREMLQRPSKNENGIYDKKARSVSDEAWSFITKCLTEPTSRFQSTIEIQKHPFFKRLHWNGLRKRAVPPFVPRLENQLDTSYFDDFNDEQVLDAYKDVYEKQRKAEQKAKSNGVMNGNQRQFLGFTFKYRPNARKPLVGRHREKRQLRKEKPEKKNNSTKQKDLITVSHNKGTTAIEDLDEDKRSKTKGHKTKSSRVHRLLERKGKDLYEFLL", "function": "Has a role in meiosis.", "AFDB_id": "AF-O94487-F1-model_v4" }, { "swissprot_id": "P9WJB9", "sequence": "MSMDELDPHVARALTLAARFQSALDGTLNQMNNGSFRATDEAETVEVTINGHQWLTGLRIEDGLLKKLGAEAVAQRVNEALHNAQAAASAYNDAAGEQLTAALSAMSRAMNEGMA", "function": "Probably plays a role in host phagosome maturation arrest.", "AFDB_id": "AF-P9WJB9-F1-model_v4" }, { "swissprot_id": "Q09525", "sequence": "MSIINDENGRGYKVHLCKTNIAQNNNKFYDMELLDEGGDFIVKLINGRIGYRGVTQLKDFDDLDRAKKFFESKFYEKTHLHWEERDDEPVPNKYAVVELATNARQTEKEVKKEEPEPEPKVDEKNTRGRKKRGIVKEKKEIKKEEEPVEEVNEKLKELMKCICDEDVHLGLLKQLKFNEAFGRPIDCLSLAQLTTGYEILSKIEESIGGKSARRSTRGRPRVADRVLAVKSDGPSLHDINKYYSLIPHSFGFCVPPKIDSHAKIQAERELLDALKGSIEASLELKDLKKTASSKDIYQRLYERLPCHLEPVSEEIAGKIGDCLAMRGPTHCYKLSLIDAFELKDPNEIPTEAPVEVQEVPKKRGRKSTKTAAPTVPPPTTKRLLWHGTRVTNVFSILMNGLQFPVGDRCGLMFGNGVYFANVPTKSANYCCPEASKRVFMLLCEVETANPLVLYESEIDADEKMEKAKKTSVYAAGKHTPRDTVEINGIPAFKSNLETIEEETRLLYDEYVMFNKEHFKIKYVVEVKVDRLTAKEMMA", "function": "Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death.", "AFDB_id": "AF-Q09525-F1-model_v4" }, { "swissprot_id": "Q9SJW9", "sequence": "MSTPGSSRSIPFKSKKRLVMDSPSSKSQTGNPNPSSVALPTPEKPLENMLSRSRNRSVALSVKEIRQAAGSRRRSEDPVASSAKSRLFFDSSSSSPSKRKSSNKNAEKEKLPEKYENLGKFFEALDNSMLLSKLRGSKPTFSNISKQIEHLTERRFCYSHLAQIKHILPEAIEIKRVLIHDETTCCMKPDLHVTLNADAVEYNDKSKSESKKIALRKVFRARLADFVKAHPQGDEVPEEPLPEPFNRRKPVENSNVEVKRVSSLMEEMASIPASKLFSSPITSTPVKTTSSLAKPTSSQINIAPTPTKPTSTPAKQTLSEINILPTPVKPVSTLAKFPSTPAIIDSTPVITATPPEFASTPARLMSTSLAARPLKRSNGHTNPDDISADPPTKLVRRSLSLNFDSYPEDERTMDFTDDIPIDQVPEEDVSSDDEILSILPDKLRHAIKEQERKAIEDQNPAISLAKRRRKMIACLPKLFNVIHYLIQSIRRWVITKEELVHKIIAGHSDITDRKEVEEQLILLQEIVPEWMSEKKSSSGDVLVCINKLASPLTIRSRLEEENKQEMAPLLS", "function": "Member of the pre-replication complex. Component of the plastid division machinery. Promotes polyloidization and regulates endoreduplication. Involved in the coordination of cell and plastid division.", "AFDB_id": "AF-Q9SJW9-F1-model_v4" }, { "swissprot_id": "P40033", "sequence": "MQPIIKGAVSSTFKRALYNFGIKEKKSVNIEMGRTQQTKKIDQSLSKKLPKGTIYDPFDFSMGRIHLDRKYQANKNSNRNDIMKSGANPLEFYARPRILSRYVTSTGRIQHRDITGLSAKNQRRLSKAIRRCQAIGLM", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.", "AFDB_id": "AF-P40033-F1-model_v4" }, { "swissprot_id": "O61788", "sequence": "MKIDTGFYSKTITPTYDSDAIDRLRYYFTVFLLTSSAFFIMAKQYVGQSIQCWAPKQFKGGWEEYAESYCLIENTYYVHMNNSNLPGPAIRENKELKYYQWVPFILFGLAVVIYIPRVIWNALQSLIGINISIVTSNLRKVAKSGFTSENPDIEKKKKEMQCKKKATSRQVDGEFWGSRLTTCILATKFLATILIFISMGFLDYFMGLGPMYGWTITKDILQGRQWQESGSFPRVTFCDFQVRELGYVNNWSLQCVLMVNMFNEKLFIALWWWYALLAILSIFDIFRVLFRFTIHHQISFITRILACTGDSAISATEVGEFNRKVLRIDGINLTHLVYANATIFEAADFVRPMWEQFKENQN", "function": "Structural component of the gap junctions.", "AFDB_id": "AF-O61788-F1-model_v4" }, { "swissprot_id": "G0KYA8", "sequence": "MGAPDEVLNIAPDEGDKLRAKALAADAEELPAGYYTSPRVVCTFMSISLTLLSTYFAFEASAAAISFIIEDIGPSENVSLFSTVWTVSQSISILLMGRLTDRFGRRGFILGTNCVGIIGGIGCLYSFQRFNTMIGAQVLLGLAAGQPGACILFIGELMSNKTKFLGNVIVAFPNVIATGFGPYIGQSLGINGNWRWIFYIYIIITAVSTVLAFIFYHPPSFAQLHGKKISRRDELLKVDWIGAFFLTAGMTLFLLGVSWGGSPDPWDSPKILGLLISGIVSCVIFVLYECYAKIDRPIIPMEFFPGTFAGFGCMLLISGVMGSMNTALFIMYPQQVQHIFSSTLSSWQEVAWMSSTAGFGIWAGIVTLGSLFHIFRHIRWQLIFGSAWVTAFLGAMASVNRHKKSEAIAFSICTGFVIGWAEDVTMLLVQFISSDENLGVTFSVVSATRAICGSIFTAAFISLYTIKFPGQLQSKLVPAVPRRWGFPGVLLVAGFAYWRALTGQCPSYWLLFPGMTSNLIQVTNDAVADSYAAAYSYVYYFAMALGVIAIIASACTKDFDHYLTSHVPHQIYAAKDADVDLLDSDRSTENVSSAAVTVSEKE", "function": "Efflux pump that provides the dual role of trichothecene export and self-protection by allowing the fungus to evade the harmful effect of its own trichothecene production.", "AFDB_id": "AF-G0KYA8-F1-model_v4" }, { "swissprot_id": "P35401", "sequence": "MGKTERKKELLELFEYEKIKGDVSYSSIMKKAGGNGKGFLDRYFALHRNYILYYKLGKSSLKPDDKQEPQGYINLMDCNPDDTKEIAPLMFQISHKHRTYIVKAKDESSMKQFLTLLIARIRSLEKIDIDKLGCTVVVLTKVKKFREVLTNPLILPDRVSPEMAEEWVKQMKNYNASFNLADPFIKQVEQISEFCRGEVKEYIDWFGGPEGPRLAMIRCEETVLSNWVEYINKTSSEITTYQDNRFFREDFKDIAVHLKNMTTFIDCYNDYMIHCRKYNNNKPNTKFLEEKQTFKEYIEKFIPKVASCNDVSLNQFYDRSLIQSSDGIVTINTSGIKKTLINQSNIISITSTTTTTTTTTTTTCSMPNMSNLIHSLDHTNLNIIDLNHSKSQQQLHPPPSPHHQHLHHQIVSNSKDFNISVSSNNFNDGNSEFPNLDINCDFDLTSASNLSSPILSSEVPSNVVDPIGSGQGGGGSGGGGVTAVTEEAINEKWHFDCNTSMIFKPPSEDGRNEGSNMSTSSITSKMSLSLNGGFDMKWVYQCGYFKSKNMGSISWNGKHWCWSHPRTSYKIKYIWDPTKQSFLNIPFKSRVGATGGGSVPSSQSTNNLQSSTSSMSSLSSSSTSTTKRSHPTTLYPDYQFKDNLLTPIIIEGRHQPSLTLIDSPLTIPNACLLTIAMTQYIQDALIHLSLGPKVLSSK", "function": "Couples activated G protein to adenylyl cyclase signal transduction from surface cAMP receptor. Pianissimo a cytosolic regulator and CRAC, are both essential for activation of the enzyme adenylyl cyclase. Pianissimo and CRAC do not function redundantly. Both proteins are integral components of the adenylyl cyclase activation pathway.", "AFDB_id": "AF-P35401-F1-model_v4" }, { "swissprot_id": "Q863H3", "sequence": "MAAFRTTAWRLISGVLGVICLVLMAALGVLLKNSLTKRSVQPGPSADLQEEYNLHEEEESCLGCLGSGCYSCQEKWIGYQCNCYFISNELKTWKDGRDFCVSHNSSLLQIQTRNEPAFMKFSTSFYWIGLSYDEEHHAWLWEDNSTLSQDLLPFFKSVNPKNCIMYNPRGRILDAYCEKKFRYICKQQLI", "function": "KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.", "AFDB_id": "AF-Q863H3-F1-model_v4" }, { "swissprot_id": "F4K0J3", "sequence": "MESTECVRVAVNIRPLITPELLNGCTDCITVAPKEPQVHIGSHTFTYDFVYGNGGYPCSEIYNHCVAPLVDALFKGYNATVLAYGQTGSGKTYTMGTNYSGDCTNGGVIPNVMEDIFRRVETTKDSSELLIRVSFIEIFKEEVFDLLDSNSSALLKNDSGVQAKHTALSRAPIQIRETASGGITLAGVTEAEVKTKEEMGSFLARGSLSRATGSTNMNSQSSRSHAIFTITLEQKKIAGGSCTTTEDGGEDILCAKLHLVDLAGSERAKRTGADGMRLKEGIHINKGLLALGNVISALGDEKKRKEGGHVPYRDSKLTRLLQDSLGGNSKTVMIACVSPADTNAEETLNTLKYANRARNIQNKAVINRDPATAQMQRMRSQIEQLQTELLFYRGDSGAFDELQILKHKISLLEASNRELHNELQERRVASEHFSKRAYDAQVEKDKLIMIIESVRNGKSLDEIESCQNEDVGLVNKYVSKIQELEGELLHIKNLKKTSNHQYSDDSYDVGPRSNNVLFPSSNESSDCEDKVMDVTDELEFQEKEIEHCSLQEKLDMELKELDKRLEEKEAEMKRFSSGGTSVLKQHYEKKVYDLEQEKRALQREIEGLRHNLASIPSGPGDGAQKLKEEYVQKLNTLETQVSVLKKKQDAQAQLMRQKQKSDDAAIKLQDEIHRIKSQKVQLQQKIKQESEQFRAWKASREKEVMQLKKEGRRNEYEMHKLMALNQKQKLVLQRKTEEASQVTKRLKELLDNRKASSRETLSGANGPGTQALMQAIEHEIEVTVRVHEVRSEYERQTEERARMAKEVARLREENELLKNAKISVHGDTMSPGARNSRIFALENMLATSSSTLVSMASQLSEAEERERVFGGRGRWNQVRTLGDAKSIMNYLFNLASTARCLARDKEADCREKDVLIRDLKEKIVKFSSYVRYMEIQKADLVHQVKAQTSAMKKLSADENLKNEHSMKKQETRNSTIVLEDMDTSDSEASDHEREDPDLDDEWKPEHESERESEQESVIKLNRKRNFKVGRRRSSVVMRRSYEENSETPSDDAVKSDVCCCTCSKSSSCKTMKCQCRATKGSCGPSCGCSSVKCSNRNADGKENNSISESEALENGENSQESDEKDKGQQQQVLASRGAMLLQNALADKPEEETNDDGGTRRRRKPLSDIGNTTGKSNVPRPSQRKKWKKTVLQLVPVGPPALPPTHTNTHLIPEANSVTVDSDTARMPENSDSGESNSIKLKLPRAMRSASSNGSNLLRERNADQNGSESGGNSGFVQSNSGRASGSRTSDEKENHTRRV", "function": "Kinesin-like motor protein involved in the control of the oriented deposition of cellulose microfibrils.", "AFDB_id": "AF-F4K0J3-F1-model_v4" }, { "swissprot_id": "Q9RCA1", "sequence": "MHFVIDRDIFVQNVNHVSKAVSSRTTIPILTGIKIVADHEGVTLTGSDSDISIETFIPLEEGDRQNVEVKQEGSIVLQAKVFAEIVKKLPEQEIEIHVQDSFVTTIRSGSSVFNLNGLDPDEYPRLPVLEEDHVFRLPQKILKDIIRQTVFAVSTQETRPVLTGVNFEIEDGILTCTATDSHRLAMRKVPVEKNDDELQFSNVVIPGKSLNELSKILDENEELLDIVVTENQTLFKLKNMLFFSRLLEGKYPVTKNMIPKEAKTSFAVHTKAFLQTLERALLLSREGKNQVINLKTLGDGVVEVTAITPEIGKVTENVATQGLEGEELRISFNGKNVIDALKVVDSESIHIAFTGAMSPFVLSPTDHDQSLHLFSPVRTY", "function": "Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.", "AFDB_id": "AF-Q9RCA1-F1-model_v4" }, { "swissprot_id": "Q759H4", "sequence": "MARTGLQRHRGKLLGTGAVLGGLVVAGVVAAVAAKRWVRRQQQRLSEQHYVREQIKRRFTQTQQDALYTMYELVPVLALVLGKELDVEELVETLKGKKLKRAGEDDEQGSGGHASAGEGSVSSTVARSKAELWQELKMRSAVKLLAVVYTTCMLLLLTRLQLNILARREYLETAIRVAKGEEATRRDAAGWLGAVWEYGAAALGALGPRPAVTAVEPVDQHEETRYVNEQAFLSLSWWLLNRGWLQFKPLIERQVEQQFGTLSPRDTLSMEQFSARLSNTIHAVNRELFDSDSRALLLRALLPDATEELHVLQQTLDEGSLRVIERDDSMLRELLQETCRCAESTASLIVLESLVNESFQFVMQQLETKVTKKLRKPATDAPEADGAADAPSQKFQVALYSVALKDCCQEMLKNGLVSMNNEYLQDLDAVPELDDLSASVYSNFGV", "function": "Involved in peroxisome biosynthesis.", "AFDB_id": "AF-Q759H4-F1-model_v4" }, { "swissprot_id": "D4B4P8", "sequence": "MVSIPLILGAIILLGTRKAATAALPPRPCAFAVTAATDDTCQSLGAQWGIGMAQFLKWNPGVNCNALVAGKTYCLSAGDSELGPTASLTPSPQVPTTSRATQTMTSKASTGTLVSRSGPIKFLNGMAPDCLFYHPVSPGDTCQSIVDRYKAFTLDQFYTWNPSVGKNCESLWLGYYVCTGVKGGPNSPSQQPPSQQPPSQQSPSQQSPSQQSPSQQPPSQQPPSQQPPSQQSNTSQQTQPNVNSKCKFHIFCLGTLAYMAFD", "function": "Might have a role in sequestration of chitin oligosaccharides (breakdown products of fungal cell walls that are released during invasion and act as triggers of host immunity) to dampen host defense.", "AFDB_id": "AF-D4B4P8-F1-model_v4" }, { "swissprot_id": "Q4P3U9", "sequence": "MPKASASSAKMTASTSNVSSSNSKLKKSKASSPSASPEVSTPSTSNSNDDQDGHVSEDMSDAEEGESQEHSASGSGISDHDDDDDPSADKDSPAADEEQDEKKVATIADDGKKVEFSDLGVIPQIVEACTNMGFKHPTPIQVKAIPEALQARDVIGLAQTGSGKTAAFTIPILQALWDNPKPFFACVLAPTRELAYQISQQVEALGSTIGVRSATIVGGMDMMSQSIALSKRPHVIVATPGRLQDHLENTKGFSLRGLQYLVMDEADRLLDMDFGPIIDKLLQSIPRERRTMLFSATMTTKVAKLQRASLKNPVRVEVDTKYTTVSTLKQHYMFMPFAHKDTYLVHLANEQAGHSIIVFTRTVHDSQRLSILLRLLGFPAIPLHGQLSQQARLGALNKFKTGGRSILVATDVASRGLDIPAVDLVVNYDIPTNSKDYIHRVGRTARAGRSGRSVTLVTQYDVELLQRIEAVIGLKMTEFPGGNDKEAVMLLSERVAEAHRAAVRELKDKGVGSAGGSGKRKRKMDGKYGDDMDRDDDQVQAGLPVSGNGRHQNQNRKKGRR", "function": "ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.", "AFDB_id": "AF-Q4P3U9-F1-model_v4" }, { "swissprot_id": "Q9V6A9", "sequence": "MEKLRSYEDFIFMANMMFKTLGYDLFHTPKPWWRYLLVRGYFVLCTISNFYEASMVTTRIIEWESLAGSPSKIMRQGLHFFYMLSSQLKFITFMINRKRLLQLSHRLKELYPHKEQNQRKYEVNKYYLSCSTRNVLYVYYFVMVVMALEPLVQSCIMYLIGFGKADFTYKRIFPTRLTFDSEKPLGYVLAYVIDFTYSQFIVNVSLGTDLWMMCVSSQISMHLGYLANMLASIRPSPETEQQDCDFLASIIKRHQLMIRLQKDVNYVFGLLLASNLFTTSCLLCCMAYYTVVEGFNWEGISYMMLFASVAAQFYVVSSHGQMLIDLSTNLAKAAFESKWYEGSLRYKKEILILMAQAQRPLEISARGVIIISLDTFKILMTITYRFFAVIRQTVEK", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol and 2-heptanone.", "AFDB_id": "AF-Q9V6A9-F1-model_v4" }, { "swissprot_id": "Q9MAH3", "sequence": "MASSSLCHRYFNKITVTPFFNTKKLHHYSPRRISLRVNRRSFSISATMSSSTKKVLIPVAHGTEPFEAVVMIDVLRRGGADVTVASVENQVGVDACHGIKMVADTLLSDITDSVFDLIMLPGGLPGGETLKNCKPLEKMVKKQDTDGRLNAAICCAPALAFGTWGLLEGKKATCYPVFMEKLAACATAVESRVEIDGKIVTSRGPGTTMEFSVTLVEQLLGKEKAVEVSGPLVMRPNPGDEYTITELNQVSWSFEGTPQILVPIADGSEEMEAVAIIDVLKRAKANVVVAALGNSLEVVASRKVKLVADVLLDEAEKNSYDLIVLPGGLGGAEAFASSEKLVNMLKKQAESNKPYGAICASPALVFEPHGLLKGKKATAFPAMCSKLTDQSHIEHRVLVDGNLITSRGPGTSLEFALAIVEKFYGREKGLQLSKATLV", "function": "May be involved in oxidative stress response.", "AFDB_id": "AF-Q9MAH3-F1-model_v4" }, { "swissprot_id": "P57487", "sequence": "MKKFCFLKIEKIKNDKKNVYCYNKYVFFFSSNKRSYFKKKTIENFYQAKIISIKIHKNAPGSFYCGCQIIWKQKKGIPNLYSCGYKIRKNKNRATRIEWEHVVPAWQFGHQKTCWKKGGRKKCMEDKKYKHIESDLHNLQPAIGEINGDRSNFMYGQLNNSVAQYGRCNMKIDFKRKIVEPPERARGAIARTYFYMNKKYNIILSEKERKMFTIWDKIFPVTKWECEREKLIFNIQGNHNDYVYKHCYKK", "function": "Has double-strand break activity.", "AFDB_id": "AF-P57487-F1-model_v4" }, { "swissprot_id": "A5DWN5", "sequence": "MSKIRTLNRQFISNLETHKAVTDAKRNLILSILKSTTTKREAKNYLTKYQNQFDLPDETPKAGTIYEQSLSRRDNQRELFIKRFLNAQNPFISIYDDEETKLQKIPLRLAIFKIKFPTISLRQWKGIAETFKRLMTLGISPIILLDYDHLSHGSFKKNELYMINQANKMLSILGKPEEQEDLKATILRNSFSVADGQITIDSLELILIPLYQGIIPIIQPIVFNADTTMQEFLKCNTLLNSLCTALVDRRTTDLLSIEKIVMIDPLGGIPSIERKQTSHVFINLSQEYSDIMSELFIGHISPKIRDLHVENLNSMNEILTSIFEKSGNDETTGIITTPEVMSIHNDQLNPIIYNVLTDRSIISSSLPSTNKRTPQLSTTIVKKGVDVQIFDQENNFSGSDFTMDNLIASKKVDKKKLTELLEDSFGKKLIVDEYYERINNRLATFILVGDYDGAAIITWEYSGDKKVAYLDKFAIAKRNQGLPGLADIIFKIILQSHPVELIWRSRKNNPVNKWYFERCCGCMSAPESQWKIFYTGDIFDKRIDRMKDKKKQNNKKKKTATMMMMNNSQKVAGVNADTHVDILKNLEQYSDICEGIVPSFA", "function": "N-acetylglutamate synthase involved in arginine biosynthesis.", "AFDB_id": "AF-A5DWN5-F1-model_v4" }, { "swissprot_id": "P48987", "sequence": "MSSSEIYRYYYKTSEDLQGFKTAAAEPYFNPMAAYNPGVTHYQFNGNTLASSSNYLSANGFISFEQASSDGWISSSPASHRSESPEYVDLNTMYNGGCNNMAQNQQYGMIMEQSVVSTAPAIPVASPPAVEVMGSSNVGTCKTIPASAGPKPKRSYTKKNQPSTTATSTPTAAAESSASVNLYTEEFQNFDFDNSALFDDSVEDDEDLMLFSGGEDFDGNDGSFDLADGENQDAAAGGSGKKRRGKQITPVVKRKRRLAANARERRRMQNLNQAFDRLRQYLPCLGNDRQLSKHETLQMAQTYISALGDLLR", "function": "Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.", "AFDB_id": "AF-P48987-F1-model_v4" }, { "swissprot_id": "P53262", "sequence": "MVFGQLYALFIFTLSCCISKTVQADSSKESSSFISFDKESNWDTISTISSTADVISSVDSAIAVFEFDNFSLLDNLMIDEEYPFFNRFFANDVSLTVHDDSPLNISQSLSPIMEQFTVDELPESASDLLYEYSLDDKSIVLFKFTSDAYDLKKLDEFIDSCLSFLEDKSGDNLTVVINSLGWAFEDEDGDDEYATEETLSHHDNNKGKEGDDDILSSIWTEGLLMCLIVSALLLFILIVALSWISNLDITYGALEKSTNPIKKNN", "function": "Accessory component of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Functions with VMA21 in assembly of the V0 complex.", "AFDB_id": "AF-P53262-F1-model_v4" }, { "swissprot_id": "Q8MY86", "sequence": "MSGLFFLLSELLILLGKINSVSKKSLCHPELFKIDNKLNWRTSEEMVLTCKAVVNEKCKKSKLQMRWYKDNELLGKKIERGLKMKYRYRKKLKLNDSGNYTCFVFNKNGNSSVFFLINVTEKENFHVNENKILDGSEISNNTLYLHPEMGMENYHVIPNDEIVMQCRFFSPISINLTVSWYQHSCDSNYHNAQLLVKDSKFNISSNKESCQSYLSHIPLDSICLYSWLRFIATSDDQSCITCLIESDNNSIEKTKFTFTVLVDAGHRPHLTFAPSSTVCQGSNFTMKCETNVPRPILYIYKLDPSFNIENPIIHLSNSTLFVNNYNEDSKRSSQSAEVLIKSMDFNYSGRYLCSLAELPLFEIMHLSVIKCSNNFFMNSVPLSIFLVIGFFVAIILLSLIIYCFFLQYKNAVDSRKHFSIRKTVIVEYESPIYKSFINGTKNFKTDVLHTNSLLPDSNPLLPPIIKIKPIKRLSQFRDGNYGEQLPSTSTDRTRLESTRHSQLENEVFECGSGNNSLSLKYGLRKSSSFEFFSLYEFPCDAKWEFPREKLKITNKKLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNVHDFVKEMEIMKHIGRHPNVIQLLGLCTQKGPLRVIVELAPYGNLRDFVRAKNKKYSKSKKIIGNFTSSILCTYSLQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRIVDYYYRKKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKVVDLIRKGFQNPKPELANFEIYRLMQHCWSLSSENRPNFFEIVEILIDIIQRIDDEPEENIYHSELNYLKMESDYLEPKCLV", "function": "Receptor for basic fibroblast growth factor.", "AFDB_id": "AF-Q8MY86-F1-model_v4" }, { "swissprot_id": "P30589", "sequence": "MAGYGHSTAGGFGSGSGSGPPGPQYMLPQYDEGDDPDADATPAGQGVRLLTNLDNSSYISVSEITSQSSHRDNIRPSRLRQAYEPSIDARTYEPSLDTRTYEPSISDRRHMYEPSIDERSSYMDPPRIPPPDGGSYVSSYMGTESMVSGHGRPWSPESATGYRVPPQGRYEPSEIDGHARPGTPGSSYGNARRPLPSAPAPLHYNSPSRAASHYPRYHGGYADDVTVSMGPDDDRTDIFGPETDLSETRHLNDAYGFRSSQITLSEDPHGTHARSRYDDEDDVSTTYSSNTGTSASGVDKFEHYGPIPEEGKHERRGVRPPQMSRKEVQLINGELVLECKIPTILYSFLPRRDEVEFTHMRYTAVTCDPDDFVARGYKLRQNIGRTARETELFICVTMYNEDEFGFTRTMHAVMKNISHFCSRNKSRTWGADGWQKIVVCVVSDGREIIHPRTLDALAAMGVYQHGIAKNFVNQKAVQAHVYEYTTQVSLDSDLKFKGAEKGIVPCQMIFCLKEKNQKKLNSHRWFFNAFGKALNPNVCILLDVGTRPGGTSLYHLWKAFDTDSNVAGACGEIKAMKGRFGGNLLNPLVASQNFEYKMSNILDKPLESVFGYITVLPGALSAYRYHALQNDETGHGPLSQYFKGETLHGQHADVFTANMYLAEDRILCWELVAKRGERWVLKYVKGCTGETDVPDTVPEFVSQRRRWLNGAFFAAVYSLVHFRQIWKTDHTFMRKALLHVEFLYHLLQLLFTYFSLANFYLAFYFIAGGLADPHVDPFNSDGHVARIIFNILRYVCVLLICTQFILSLGNRPQGAKRMYLASMIIYAVIMVYTTFATIFIVVRQIQPSQKSDDKPDLELGNNVFTNLIVSVASTLGLYFVMSFLYLDPWHMFTSAIQYFVLLPSYICTLQIYAFCNTHDVTWGTKGDNVMRTDLGGAIGKGSTVELEMPSDQLDIDSGYDECLRNLRDRVMVPAVPVSEDQLQQDYYKSVRTYMVVSWMVANATLAMAVSEAYGDSEIGDNFYLRFILWAVAALALFRALGSTTFAAINLVSALVEGRVRLRLNMKGFRWIKEKWGDADVKGKFEGLGDRARGLARR", "function": "Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.", "AFDB_id": "AF-P30589-F1-model_v4" }, { "swissprot_id": "Q75WF2", "sequence": "MPSSVIMFTFLALTVLTAVMVGTSEAVSCMDNKNKPVDWFIVYKLPQDSASSKPVIREGYGQMYMDVNNQALKFSSTSLKDDDHAIAYTVDDIYKNHGKGNLAHVMYNDQPPAGEEIQSGLVGHTKGVLAFDGTSGFWLVHSVPKFPLPASKSYNWPDNAKRNGQTLLCITFKYDQFEKIGQQLKYNYPGVYDSDLPSKLVGKTPSIVDLVKNVHVTSPPWNRQLNLQSKSGQTFVSFNKASKWGEDLYKNWLATHFKSGLYCETWQNGGRNLNSSCEAGLNVYNVKKVSLSGGSDFKGTKDHSKWAVTTKSGLKWTCIGGINRQTSQMYRGGGAVCLENANVHKAFYDSVAEYEPCT", "function": "Hydrolyzes DNA with an optimum pH of 7.2. Is potently hepatotoxic. It induces caspase-independent apoptosis (on rat liver cells) through the following procedure: binding to a specific receptor in the cytoplasmic membrane, entering the cell, entering the nucleus and degrading DNA.", "AFDB_id": "AF-Q75WF2-F1-model_v4" }, { "swissprot_id": "C5DHJ1", "sequence": "MSPTQPNPAAALSGSAEPQTKRIYISNLDFSTTEEELEQFLQEFRVVSVLIPSQTVRGFRNSTVRPLGIGYADFASAADALQAVENLNGKQLRERTLKIKMYVPYSPRARAERRKEKRKVPAPQAEENPDAAPQDAQQPQPPAPAEEPTSKDTVYCAYLPSKVTDVELREFFADYQPQDIYVYRTNGSRRKVYFHRRFTAALVTLGGEAELANAIETLGTRRLMGKKITLRPARLSKVEEVQHAAARKLELEQIQQQTRQIAEHAMAMEEHRQQEAEIPAAETPDDVAATA", "function": "May be involved in the modulation of rDNA transcription.", "AFDB_id": "AF-C5DHJ1-F1-model_v4" }, { "swissprot_id": "Q8INF2", "sequence": "MLDLYRRTVARFPLGSVSYMFAYGSGVKQQEGYGKVGNGNNLRPPPGTVVDLVFCVRDARGFHAENLHRHPDHYSALRHLGPNFVAKYQERLGAGVYCNTLVPLPDVGITIKYGVVSQEELLEDLLDWRHLYLAGRLHKPVTNLVNPSDNPPLKAALERNLVSALQVALLLLPEKFTAYGLFHTIAGLSYKGDFRMIFGENKQKVHNIVSPQINDFFALYQPSLGQLSDYVAVNMKGQEPGSRKPAIIFEQDKSSSATCQHLRQLPRELQKRLQRNAACRGDYTQVVNHLSMASQLPEVLQASVNDIVWRSSVTQSIKNIPSAGILKSLAYSYRKAQKTFAV", "function": "Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.", "AFDB_id": "AF-Q8INF2-F1-model_v4" }, { "swissprot_id": "P04706", "sequence": "MRVLLVALALLALAASATSTHTSGGCGCQPPPPVHLPPPVHLPPPVHLPPPVHLPPPVHLPPPVHLPPPVHVPPPVHLPPPPCHYPTQPPRPQPHPQPHPCPCQQPHPSPCQLQGTCGVGSTPILGQCVEFLRHQCSPTATPYCSPQCQSLRQQCCQQLRQVEPQHRYQAIFGLVLQSILQQQPQSGQVAGLLAAQIAQQLTAMCGLQQPTPCPYAAAGGVPH", "function": "Seed storage protein. It accounts for about 15% of the total endosperm protein content.", "AFDB_id": "AF-P04706-F1-model_v4" }, { "swissprot_id": "A0QNH6", "sequence": "MSKCPRCFTALNPNQYLWTLPEQSGGTRYRDEVATAYSGAPADCGPLYTWSRSPGYNGPPPPTSEATRALQAPAVEICPVCHFTLPEGWREGHAICIALAGARATGKSLYIAVLVKQLELLCERFGVSMQPVTRGTAQAYATNYETPLYVQRGLIPPTPTVRTQTSDHREPLMFSLGIWHGVRRFLVLRDVAGEDMESGDLHAPPFRFFAHADAVFFMFDPLRVKTIRDQLHDLLPAQVVSGGDPRTVLTNVLTAVSPGQPKLAVILSKFDVLRALRDVEGSEWGLIMSNGGAAYLRDTSDGQQYDETDGQLLHEEVRSLLLRLHGGSILAAVENPATGVRLQSRNFVVSALGHPPSGNRLHARGIAPFRCVDPIRWVTSGFGVL", "function": "May be involved in assembly of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Involved in DNA conjugation in recipient (MKD8) strain.", "AFDB_id": "AF-A0QNH6-F1-model_v4" }, { "swissprot_id": "Q9SZD1", "sequence": "MGEDGGGGEFPPKKDGVEEGFPTKKPARQLDFTGGSDEHSLSKPAAPTVVATSVKPIISSSVPSTIRPGMTIAIGQVTQVRPTLPMATTMSNPPSQSQIVNAPIRHPIPESPKARGPRPNVEGRDGTPQKKKQCNCKHSRCLKLYCECFASGTYCDGCNCVNCFNNVDNEPARREAVEATLERNPFAFRPKIASSPHGGRDKREDIGEVVLLGKHNKGCHCKKSGCLKKYCECFQANILCSENCKCLDCKNFEGSEERQALFHGEHSNHMAYLQQAANAAITGAVGSSGFAPSPAPKRRKGQEILFNQAIKDSSRLSHFPQVNNGRTGGPTSGTSPSPVSRAGGNASSVPSKFVYRSLLADIIQPHDVRALCSVLVTVAGEAAKTSTDKRNEIENRVDDQTETSLASSAQDQPQGNNNAADVEMVATDHNQADKSGPEESNSDGVDASKVTPLSPATLALMCDEQDTIFMVAAPSPNGSVDPNGCRPNSQGQSEIYAEQERLVLTKFRDCLNRLISYAEIKESKCLSLARMHIQPPAIATVKTENGIQQQVPIVNGASRTNCQPTLNKPQPMQLMNTTSAAPATATNTQHLQKPPALSEKKDP", "function": "Plays a role in development of both male and female reproductive tissues.", "AFDB_id": "AF-Q9SZD1-F1-model_v4" }, { "swissprot_id": "P43265", "sequence": "MKSVVRSKGTQALFRRFSSALGDSINPNQVGVGDNVIRVNGRLFEVDKVQEKGLKTSVLDNGTKVITLDNGGSVAQLTFLYKDGPVYENIFNAGISSFMKHALTKDGLTSSEYITKTFLQKAGIIVHEPTVVNKSAIAFTVEGFRDTLAQPAVADKFWQSLLFPRFSPENVKEVKRLVELESKETKRDSPFAYLQDILHKTAFKGSPLGHTSFVPAYNLGYIDSNKLFDRWDAHYGFGNIAVIATNIEHEAVLAAITDSAWVARAHNKVGGVAAPASKYSGGEGYDVVHRAKEFDDQFTDVYSTYTAYAFKAPGRSNLKEHAASLVIAQALSNAVSPVLNTSFAPKRLEVFYQAYDTVGLIGLSSVQASNAQLKAFKAALSKIGTLSEADLAVHKSAALLTAYGNVESWRATQATLIDSFNTTGQPLSPLEIVSAIKAVSADTVKSVVATMLGSPATLVHHGDSPCAPTLDALQ", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.", "AFDB_id": "AF-P43265-F1-model_v4" }, { "swissprot_id": "P32959", "sequence": "MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAEMTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRHLLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVLLAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETYVLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRLNNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTEYEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTENERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRTK", "function": "Probably involved in peptidoglycan modification during cortex synthesis.", "AFDB_id": "AF-P32959-F1-model_v4" }, { "swissprot_id": "Q87AR6", "sequence": "MIQRPTFFSPIHLLAVLLATFILITGCHRETKKNADDGMPVEHLYDKAHTLMKKGNWAGAELSFKRLIAQYPYGPYTEQAMVENAYAQYKSGKHDDAVSSIDRFIRTYPTHHNIPYMYYLRGLSNSNRDTIFLRKVWSLDLSRRDLSAPQQAYNDFKTVLDRYPNSRYATDAKKQMTELRNMFAQYEMNVTLYYLRRTAWVAAAGRANFLLETYPQSPFQYDAVAALGEAYTHLGNKTLADNARQVLQTNAPDHPWLKGKKWPKYPAAIRKLNPFAGEKSAATGQTNAVVNSN", "function": "Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.", "AFDB_id": "AF-Q87AR6-F1-model_v4" }, { "swissprot_id": "P38922", "sequence": "MSDQERGSENNNRSRSRSRSPVRRRMSDDHGYERDNHLSRRSGNYNGRRKFADTYRGSRDRGEYRGGRERSDYRERERFNNRDNPRSRDRYDDRRRGRDVTGRYGNRRDDYPRSFRSRHNTRDDSRRGGFGSSGARGDYGPLLARELDSTYEEKVNRNYSNSIFVGNLTYDSTPEDLTEFFSQIGKVVRADIITSRGHHRGMGTVEFTNSDDVDRAIRQYDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVKNLPASVNWQALKDIFKECGNVAHADVELDGDGVSTGSGTVSFYDIKDLHRAIEKYNGYSIEGNVLDVKSKESVHNHSDGDDVDIPMDDSPVNEEARKFTENVVGGGERNRLIYCSNLPFSTAKSDLYDLFETIGKVNNAELRYDSKGAPTGIAVVEYDNVDDADVCIERLNNYNYGGCDLDISYAKRL", "function": "Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus. Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded. On correctly spliced mRNAs, GBP2 and HRB1 recruit MEX67 to allow nuclear export. On faulty mRNAs, GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation.", "AFDB_id": "AF-P38922-F1-model_v4" }, { "swissprot_id": "A0A144LVL3", "sequence": "MMIKIAVVLCAVMATSMVFANDVKEQELADLLDLLISEEVSSPDDAVAESWGHKLRSSWNKVKHAVKKGAGYASGACRVLGHSPQEARAKVLEAFPEMKESDLDEEQVGKYCAVAHAIHGR", "function": "Has antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and against fungi with minimum inhibitory concentration (MIC) between 0.78 uM and 50 uM. Shows little hemolytic activity at concentrations up to 12.5 uM but >50% lysis at 100 uM.", "AFDB_id": "AF-A0A144LVL3-F1-model_v4" }, { "swissprot_id": "A5UK38", "sequence": "MKILFIGSRLYDDIDYYVRENGIESIITESNEDAINLDLPDQVFIVPRGMDSPKQIAISQNVDAVVPLIGIDPPLIEVAKMKEELEAETDIPVIAANVRAVRLTSDKIKTKEFYNEIGVPTPQYQILAKDDFESKLKMEFPVVLKQGQGQGGKDIKVAESLDDVKEYFEEFDHALCEKFIEGSEISIEVLGYNGEYVPLSPIYKGETTLEGIHPLNKIKTAPCLVEGLDNNLVQRTAYKVAKNLGSDGIFEMDFMFSKDEQQLYAIEVNTRPNGTRYLTTATCGVNSLCELVNMAAGKFSIKDIQDKLEYYYATEIPIGRYKGPDLNEPLKSFKNNDWVVHGPEGYQRITIRADSKEQLDRYVEDLI", "function": "Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate. In M.smithii, the predominant archaeon in the human gut, one function of this enzyme may be to sequester ammonia, a scarce nutrient in the intestine which is the major source of nitrogen in M.smithii for the biosynthesis of nucleotides, amino acids, and many other metabolites.", "AFDB_id": "AF-A5UK38-F1-model_v4" }, { "swissprot_id": "Q336N8", "sequence": "MQQVEGRNCLPAEVRIGLETLKRRRLERMRLTAQNNAGDGPPVPARSGGDALRTPANCGVRLHANNGTALPSRTTQNKDPFAKRRVDKFDMSSLEWIDKIEECPVYYPTKEEFEDPIGYIQKIAPVASKYGICKIVSPVSASVPAGVVLMKEQPGFKFMTRVQPLRLAKWAEDDTVTFFMSERKYTFRDYEKMANKVFAKKYSSASCLPAKYVEEEFWREIAFGKMDFVEYACDVDGSAFSSSPHDQLGKSNWNLKNFSRLSNSVLRLLQTPIPGVTDPMLYIGMLFSMFAWHVEDHYLYSINYHHCGAFKTWYGIPGDAAPGFEKVASQFVYNKDILVGEGEDAAFDVLLGKTTMFPPNVLLDHNVPVYKAVQKPGEFVITFPRSYHAGFSHGFNCGEAVNFAISDWFPLGSVASRRYALLNRTPLLAHEELLCRSAVLLSHKLLNSDPKSLNKSEHPHSQRCLKSCFVQLMRFQRNTRGLLAKMGSQIHYKPKTYPNLSCSMCRRDCYITHVLCGCNFDPVCLHHEQELRSCPCKSNQVVYVREDIQELEALSRKFEKDICLDKEISGFDSYKQAEKNEPFFEITRNLRNTEVNLIEDAFSGATAADAAKSSPATSTLTSFAQHDVPVLAEAIVCANQADQLYSTTEQTISSPLVKGTDAVGANSSSMADANNGTGSCNASAVEYSGNSDSESEIFRVKRRSGVSVKPASDAKTSNLSDQQVLRRLKKVRPEIQQHNKRPEDYGHCSVPSGRMSMKNLNSSSSCGEEHWRMKRRQLETQQDESSYSAKQKSYSYPSTSYSFRGEFVEMSRDAAAEVRPKRLKIRLPSSSTNRVVEQGSSGQRFTRDDKSLGCWPAI", "function": "Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me3 and H3K9me2. No activity on H3K4me3, H3K9me1, H3K27me2 and H3K36me3/2. Involved in the control of floral organ development by demethylating H3K9me3 and H3K9me2 in the promoter regions of DH1 and MADS47. The 'Lys-9' demethylation of these two genes is required for induction of their expression.", "AFDB_id": "AF-Q336N8-F1-model_v4" }, { "swissprot_id": "Q9KID9", "sequence": "MTDAGRQGRVEALSISVTAPYCRFEKTGSPDLEGDETVLGLIEHGTGHTDVSLVDGAPRTAVHTTTRDDEAFTEVWHAQRPVESGMDNGIAWARTDAYLFGVVRTGESGRYADATAALYTNVFQLTRSLGYPLLARTWNYVSGINTTNADGLEVYRDFCVGRAQALDEGGIDPATMPAATGIGAHGGGITCVFLAARGGVRINIENPAVLTAHHYPTTYGPRPPVFARATWLGPPEGGRLFISATAGILGHRTVHHGDVTGQCEVALDNMARVIGAENLRRHGVQRGHVLADVDHLKVYVRRREDLDTVRRVCAARLSSTAAVALLHTDIAREDLLVEIEGMVA", "function": "Involved in the biosynthesis of the macrocyclic amino acid-linked polyketides FK506 and FK520 which are potent immunosuppressants that prevent T-cell proliferation through initial binding to the immunophilin FKBP12. Catalyzes the hydrolysis of chorismate via a 1,4-conjugate elimination of water to yield (4R,5R)-4,5-dihydroxycyclohexa-1,5-dienecarboxylic acid (DCDC).", "AFDB_id": "AF-Q9KID9-F1-model_v4" }, { "swissprot_id": "Q3UG98", "sequence": "MKLNQNTMLVGKKVVLVPYTSEHVPRYHEWMKSEELRHLTASEQLTLQQEYEMQCSWCEDEDKCTFIVLDAEKWQAQPRPPEESCMVGDVNLFLTDLEDPTLGEIEVMIAEPSYRRQGLGTEASLLIMSYGVTKLGLTKFEAKIGQENEPSIRMFQKLHFKQVAMSNVFQEVTLRLAVSEPERKWILEQTSHMEERPYRTRKAEPVTATLSEQKSWNCPLPRPDGCMGDTSAVSSVCARLS", "function": "N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin.", "AFDB_id": "AF-Q3UG98-F1-model_v4" }, { "swissprot_id": "P32144", "sequence": "MSLTELTGNPRHDQLLMLIAERGYMNIDELANLLDVSTQTVRRDIRKLSEQGLITRHHGGAGRASSVVNTAFEQREVSQTEEKKAIAEAVADYIPDGSTIFITIGTTVEHVARALLNHNHLRIITNSLRVAHILYHNPRFEVMVPGGTLRSHNSGIIGPSAASFVADFRADYLVTSVGAIESDGALMEFDVNEANVVKTMMAHARNILLVADHTKYHASAAVEIGNVAQVTALFTDELPPAALKSRLQDSQIEIILPQEDA", "function": "Involved in the regulation of the sulfoquinovose operon. Represses the expression of the yihUTS operon and of the yihV and csqR genes. Binds DNA inside the spacer between the bidirectional transcription units comprising the yihUTS operon and the yihV gene, and upstream the csqR gene itself.", "AFDB_id": "AF-P32144-F1-model_v4" }, { "swissprot_id": "C4R3U0", "sequence": "MSELTEAEKRQLLREKRKAKLSQGGGLDRLKKITGENNSKLSTDVPTKEPTADATTTATELPTQGLETRINAHDDPVSEIPDPLNEGFDGKEPDLDQLIASMFNKSAGHENPNSEEQGVPELMRRFSSILQGGDSGAAGLGAEAGGINPLDLLNSLGGSNIGKAQEEYGSTPEEIEFNKKSIAYKKHQNEVLKAKILVVRLVLILSLLFVYGRDFSLSLFTQTYAPNGSSFMRVFLTLELIFQTSLFFFISKNKNFTDDSLISKLLNIGGAFIPATYRNLLQTASKYQVLLSMFLFDLSIVVVVFAIRAAFNF", "function": "Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.", "AFDB_id": "AF-C4R3U0-F1-model_v4" }, { "swissprot_id": "Q9Y783", "sequence": "MVNLGSIWQNLLASQAPLQSMTGNATTMAGLATYSLPQLPYAYNALEPYISAQIMELHHSKHHQTYVTNLNNALKVHVAAIASSDIPAQIAQQPAIKFNGGGHINHSLFWKNLAPAETPETNYSKAAPSLAAEIEKTWGSFDEFKKAFSAALLGIQGSGWGWLVKESTAEKGRLRIITTKDQDPVVGGEVPVFGVDMWEHAYYLQYLNGKAAYVENIWKVINWKTAEERFQGSREDAFADLKALL", "function": "Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.", "AFDB_id": "AF-Q9Y783-F1-model_v4" }, { "swissprot_id": "Q25464", "sequence": "MLFSFFLLLTCTQLCLGTNRPDYNDDEEDDYKPPVYKPSPSKYRPVNPCLKKPCKYNGVCKPRGGSYKCFCKGGYYGYNCNLKNACKPNQCKNKSRCVPVGKTFKCVCRNGNFGRLCEKNVCSPNPCKNNGKCSPLGKTGYKCTCSGGYTGPRCEVHACKPNPCKNKGRCFPDGKTGYKCRCVDGYSGPTCQENACKPNPCSNGGTCSADKFGDYSCECRPGYFGPECERYVCAPNPCKNGGICSSDGSGGYRCRCKGGYSGPTCKVNVCKPTPCKNSGRCVNKGSSYNCICKGGYSGPTCGENVCKPNPCQNRGRCYPDNSDDGFKCRCVGGYKGPTCEDKPNPCNTKPCKNGGKCNYNGKIYTCKCAYGWRGRHCTDKAYKPNPCVVSKPCKNRGKCIWNGKAYRCKCAYGYGGRHCTKKSYKKNPCASRPCKNRGKCTDKGNGYVCKCARGYSGRYCSLKSPPSYDDDEY", "function": "Provides adhesiveness to the mussel's foot. Mussels produce one of the strongest water insoluble glues. The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins.", "AFDB_id": "AF-Q25464-F1-model_v4" }, { "swissprot_id": "Q9SRQ3", "sequence": "MANSHTDDLDELLDSALDDFKDLNLSHQRNQREAQEEEEKKRKEETVLLPSGVQGLGMGLPDMRSKKRGKQKVSKEDHVAEALDKLREQTRETVKGLESISSKQLPASDDDGMVEDFLKQFEDLAGSKDLESIVETMMQQLLSKDILHEPMKELGARYPKWLKENEASLSKEDYKRYSQQYKLIEELNAVYENEPNNSSKIMEIMQKMQECGQPPSDIVKEIDPGFDFASLGQISPEMLESSPNCCIM", "function": "Contributes to morphology determination of peroxisomes, but not to import of peroxisomal matrix proteins. Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Required for transport of APEM9 to peroxisome membranes. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer.", "AFDB_id": "AF-Q9SRQ3-F1-model_v4" }, { "swissprot_id": "O51653", "sequence": "MKYLQTVASMKSKFDIVAIVEQYIKLVKSGSAYKGLCPFHAEKTPSFFVNPLQGYFYCFGCKKGGDVIGFLMDMEKINYNDALKILCEKSGIHYDDLKISRGSENKNENKDMVSKIYSLNSRLINTIKFFLSKNKKALDYVLKSRAISKEIVDLFELGYLPFNFKNGLELHDFLVSKGYSSEVLRKSGLFSKTNPKVSILFQRLIFPIKDFKGNVVGFGGRDLDGKGSKYINLGETEVFKKRELLYGFYEGFEEIKSTKSVILVEGYIDVLAFFTSGIKRAVSTLGTAFSKEHLALIQRYADEIIFSFDGDDAGLSATLKAYQICLPFNINVSVVRMDFGTDPADVLKSEGVDSLQKILNNRCDAFEYLLDVYSNKYNLNKTVDLNAMINLFLNLINLSKVDTQKKIFLDKLSNKLGIGVTTLLKDYYRIKERFVVDNNKRNLYAHNDDSYERYLIVALLKNFSYFSIVRRNIIDSDLINVDARKVFMCFENLFENNKDFSLMDLKKNLKDTYKVSEFFLKKF", "function": "RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.", "AFDB_id": "AF-O51653-F1-model_v4" }, { "swissprot_id": "Q5DTW7", "sequence": "MNWNTKQENVPKPPPYSKTQSSILQHFLMTSTTSQSSFNYSPHNQEASQTSFNYSLHNQEACMYSGNSNSVSQPLLSGRNYITPQTQISVSNMPTRTIVASQSSMERVVSTNGKGPQQPNHNLQTVSSGIMQNVWLPSHTEATISHNPDGGTNMPYMHPPQNQLVTSDTYSMQLQMAPLHSGKVPMTHQGSQGLNHFIPDQLVDWTQYTSNELSYPEYRPPPKQYSYILPATTSLQVKNNQLPTYTQSLQSKHSVPLSSHQYAAEASKRLSALPYSCRYENQHVQNAQPVSKHLPMEVPQSSEVHSSEKKKDTYRGFKQQWQNPNEKVSIGQFSEVKINIKQPYSESVRPSGDGVQALVQNNQEKRKYTYNPNTNQVIDTNATKEKLVRDIKSLVEIKKKFSELARKIKINKSLLMAAGCSKTANTSYTEPIQHSEFSAKEMSAKNGNDCSMELLATCLSLWKNQPSKTTEENVPKPLEEKQCNTSRISTTVVGSANPTNEVHVKSLCSGVGNSQKMMSSSQTVLPVLIPSCESSGVAVGKGTELQIAVVSPLVLSDTNTLPGKDSVPEVLPETLYPVVKEGSVCSLQTQPTETVALPFDVIGAVASNNISAEIPLPVDKEKQHKPIQGDPDIADSSLGKHSPLGTEVLPKPMDSTIVSGPMLQIESICSLAEGDVSYNSQIAEIFNSVQTEPQKPSPNQVIDSQQEQVYDTTENKDFSLQKDKCVQCTDVPHEVPEQPEPLQPEEPASSEYVEANREATEESCREYTGRKESTAKDVCLPAAIQQDPHPRETDMFSKSDHSLPAINEINDESEPISYLHDQLSELLKEFPYGIETFNRHEVSLDQQKTHKIVENQTGGKTSNVSGDSTDQIKITVLNSEQIKELFPEDDQPCDKLAEPENKEIVAEVKSPCDSQIPREESHDLGMLDPEKDKIHCCALGWLSMVYEGVPQCHCSSTEKKEKDQCLDINSSKQGEQPCNSGITIFEINPVSNNSKTPLTQATEEGHFSAVHGEKTKASKTKDNREGQELACHFSAKCYKKDKKGNFKIRHDTSLKMEQKLKNISSKCDIPNPSKCNKIAAPEILHVTTSNSAKNMPFSKQASQESLQKKHTSQDLGPVKAPIELSSNTDPCRSNTSSVQSVSPEKKKLKFKAGGSRLKYFEKRKTDHVIIPDVEIKKKKYEKQEQNKNAGDTLKLCSILTESNERASVQEKTVPSPESSDPKGSSSKSTRVITVQEYLQRQKDKQITGNNASRNICVETVLCDSGHTKTSKHSAAVSWGKLVEGQSISAETAKELEHNSSSHGKDFKIHHSEASRTHSVSNNNKGKFDGKQPDKMFKNKTSMNNESNQMPLQVKEQRKQYLNRVAFKCTERESICLTKLDSASKKLSIEKKSGEYTSKTKDTDKPSMLEFKLCPDVLLKNTSTVDKQDCPGPGPEKEQAPVQVSGIKSTKEDWLKCIPTRTKMPESSQRDSADSRLSKRSLSADEFEILQNPVKESNIMFRTYKKMYLEKRSRSLGSSPVK", "function": "Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.", "AFDB_id": "AF-Q5DTW7-F1-model_v4" }, { "swissprot_id": "P47084", "sequence": "MLRSLHSAATLSNKRFYSLISHSNRKNIIKKLLRHPSFDPIRHHLPEDITTIDPYSLSQNVIESLNKLEVPKKDAAMVHNMMIENLSDLDYGVATIHSNNLRDLDLKPSLPAIKQIIRNNPGRVQSSWELFTQYKASMENVPDELMEVVLEKIIKFDKAEKVDGKKSLTYQDLVRCLYLINHFSSNYNLPSELVEPILIYIVDNGIPNVLGSVLKYKIPLSFFDKYVSEMTQYQICELYDFYSLDNIVADPLVLHKCLTVLGENEKIQQTEEEKEIISKLEEEIDIVKSQCHDNWSLEFPNWSVRKTATSFEELFLEIQKRNIDKKDFELAHKLLRLIGAFKGKVSLFFKLYDEYLLKFKNNEDDLMFEAFLTLCCQGYKSSNEKMLQYAEAFIKEDFDSKLESKIQSVLIVANAKANIDLSLKIYNSNISTAKREKDKYTDLAESDVLTESLILAFLSRDDADFARVIFDGALGEKLISGPTAAKKIKNLLAQYGEALETKTSKQVMQTKIEHYMESI", "function": "Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression.", "AFDB_id": "AF-P47084-F1-model_v4" }, { "swissprot_id": "P30300", "sequence": "MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVIKEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAIQRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEEDVEQALKAGAVAVTTSNTKLWKKYENFLTESD", "function": "Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA. May also regulate expression of the glpFK operon.", "AFDB_id": "AF-P30300-F1-model_v4" }, { "swissprot_id": "Q99728", "sequence": "MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS", "function": "E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.", "AFDB_id": "AF-Q99728-F1-model_v4" }, { "swissprot_id": "P07884", "sequence": "MLKGPLKGCLNMSKKVIVIAGTTGVGKSQLSIQLAQKFNGEVINSDSMQVYKDIPIITNKHPLQEREGIPHHVMNHVDWSEEYYSHRFETECMNAIEDIHRRGKIPIVVGGTHYYLQTLFNKRVDTKSSERKLTRKQLDILESTDPDVIYNTLVKCDPDIATKYHPNDYRRVQRMLEIYYKTGKKPSETFNEQKITLKFDTLFLWLYSKPEPLFQRLDDRVDDMLERGALQEIKQLYEYYSQNKFTPEQCENGVWQVIGFKEFLPWLTGKTDDNTVKLEDCIERMKTRTRQYAKRQVKWIKKMLIPDIKGDIYLLDATDLSQWDTNASQRAIAISNDFISNRPIKQERAPKALEELLSKGETTMKKLDDWTHYTCNVCRNADGKNVVAIGEKYWKIHLGSRRHKSNLKRNTRQADFEKWKINKKETVE", "function": "Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in the anticodon loop on a specific subset of tRNAs both in the cytosol and the mitochondrion, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This modification optimizes the codon:anticodon fit in the ribosome and promotes translational fidelity. Competes with the farnesyl pyrophosphate synthase ERG20 for the common substrate dimethylallyl diphosphate (DMAPP).", "AFDB_id": "AF-P07884-F1-model_v4" }, { "swissprot_id": "Q9LW31", "sequence": "MMVDENVETKASTLVASVDHGFGSGSGHDHHGLSASVPLLGVNWKKRRMPRQRRSSSSFNLLSFPPPMPPISHVPTPLPARKIDPRKLRFLFQKELKNSDVSSLRRMILPKKAAEAHLPALECKEGIPIRMEDLDGFHVWTFKYRYWPNNNSRMYVLENTGDFVNAHGLQLGDFIMVYQDLYSNNYVIQARKASEEEEVDVINLEEDDVYTNLTRIENTVVNDLLLQDFNHHNNNNNNNSNSNSNKCSYYYPVIDDVTTNTESFVYDTTALTSNDTPLDFLGGHTTTTNNYYSKFGTFDGLGSVENISLDDFY", "function": "Transcription regulator involved in gene regulation during late embryogenesis. Its expression to the epidermis is sufficient to control foliar organ identity by regulating positively the synthesis abscisic acid (ABA) and negatively gibberellin production. Negatively regulates TTG1 in the embryo. Positively regulates the abundance of the ABI3 protein in the seed. Cooperates with KIN10 to regulate developmental phase transitions and lateral organ development and act both as positive regulators of abscisic acid (ABA) signaling during germination.", "AFDB_id": "AF-Q9LW31-F1-model_v4" }, { "swissprot_id": "D9PU00", "sequence": "MESELYECDVLIIGSGGAGCRAAIEVSEHKLTPIIVSKGLSFKSGCTGMAEGGYNAAFACVDPEDSPDVHFEDTMRGGGFINDPRLVRILVDEAPDRLRDLEEYGALFDRQESGLLDQRPFGGQTYRRTCYHGDRTGHEMITALKEEVIRRDIETIDEVMITSLLVEDGSVLGAMGVSIMNSEPVAFRASSTILASGGAGHIYPVTSNTMQKGGDGFAIAWKAGADLIDMEQVQFHPTGMVYPESRRGVLVTEAVRGEGGILLNSEGERFMGRYDPRGELATRDVVARAIYTEIMEGRGTENGGVYLDVSHLPDEVIEEKLETMLLQFLDVGVDIRSEPMEVAPTAHHFMGGVRIDEWGRTNLKNLFAAGEVSGGVHGANRLGGNALADTQVFGRRAGISAAKNAMSSSRRHVRSLIEEEEQRIKDMVRDGSIRPAEIRDELHEAMWSDVAIVRSRRSLESAMSRISTLMDKLGDLDVPETGGFNSNLLEALELENMLITASLVTRSALIREESRGSHYREDFPETRPEWKRSILLNRKMEPQFIGR", "function": "Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.", "AFDB_id": "AF-D9PU00-F1-model_v4" }, { "swissprot_id": "Q5AUY3", "sequence": "MTRTSPTLPVIILGAGMVGLTLAQALKKAGIPYEVYERDSAADTEKGRGWALTVHWALNALEECLPAELFNRLEEIQVDPTLDDSRRFCFLDLSTAIPKYVIPPSKRLRVNRRLLGNLLGEGLDINYNKTLSSFHVSPETPDSVTVTFTDGTSTTGCLLVGTDGRNSKTRRLLLGEEAGALNPLPVRSIGTTITMTPEQFAPIREIDPLLFQGSHPETGVYMWFSLVSSPTINGSKDTPNPFYEGQLIQSWLYKSEKDAVPETDADRLALFKNNAQHFQRRLREAIETLPEDSKVLHIKLVDWVPVDWDNRGGRVTLAGDAAHAMTSYRGEAFNHGVADAAMLSRNIIAAWTNPGMTGGIADAPDSPIVSKRAKIAREARDARARAKLSEIAV", "function": "FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives. The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step. The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA. The roles of dbaB, C, E and F have still to be determined (Probable).", "AFDB_id": "AF-Q5AUY3-F1-model_v4" }, { "swissprot_id": "Q2W2I2", "sequence": "MNELMKIFGQVSGTQSFDQIRISIASPERIRSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYRGIICEKCGVEVTLAKVRRERMGHIELASPVAHIWFLKSLPSRIGLLCDMTLKDLERILYFENYVVVEPGLTPLKIRELLTEEQYMRAVDEYGEDAFTAKIGAEAIRDMLTVIDLETEKAQLKVDLKETTSEAKRKKLVKRMKLVEAFMESGSRPEWMILEVIPVIPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLIELRAPEIIVRNEKRMLQEAVDALFDNGRRGRAITGANKRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFVYSKLELYGMATTIKAAKRMVEKERPEVWDILEEVIREHPVMLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNILSPANGKPIIVPSQDIVLGIYYITMERDEVPGQVLKIRSMDELKGAIANNAILFYCPTDPNTKIDTKDLDTLLDRLASRNVTAHRRVNPSSKDALEAGLKGGHLRLFNVEKPGVPLVFADVNDAEKAIKDGKAILFKVPVFVNMAEIEEALTEKTITLHTKIRARFDTVDSEGTPVTQIVDTTPGRMMLSVILPKNKNVPFSLINRLLTKKEIQNVIDVVYRHCGQKETVIFADRVMGLGYSNAFKAGISFGKDDLVIPPEKETLVGETEEKAKEYEQQYQDGLITQGEKYNKVVDAWSKCTDDVADAMMKQISSLVPGKQINSIYMMAHSGARGSAAQMKQLAGMRGLMAKPSGEIIETPIISNFKEGLTVLEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDAIICEEDCGTTNGLTVSPVIEGGEVIASLAERILGRSAARDIVNPLTGEVIVKAAQMIQETEVELIDAAGIETVVIRSVLTCDSEEGVCGSCYGRDLARGTRVNVGEAVGVIAAQSIGEPGTQLTMRTFHIGGAAQRGAEQSSIEATFDGTVQVINRNVVVNSSGASIVMSRNCEVALLDINNRERARHRVPYGAKLLVDEAQKVTKGTKLAEWDPYTLPIITERAGVAHYVDLTEGLSMREVVDEATGIASKVVVDWKQQPRGADLRPRVTLRDEKGEELLLANGLEARYFMSVDAILSVENNTKVNAGDVLARIPRESSKTRDITGGLPRVAELFEARKPKDHAIISDCDGRVEFGKDYKSKRRILVVPEEGDAIEYLIPKGKHISVQEGDYVRRGDPLMDGNPVPHDILKVLGVEALAQYLINEIQEVYRLQGVKINDKHIEVIVRQMLQKVEITDPGDTTLLVGEQVDRVEFDIENSKAIREQGRPASGTPVLQGITKASLQTHSFISAASFQETTRVLTEAAVSGKVDSLQGLKENVIVGRLIPAGTGAVMNRLRAIAAKRDKDMQVEGESEVPAIPPVAEGSAPEAPPAE", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "AFDB_id": "AF-Q2W2I2-F1-model_v4" }, { "swissprot_id": "Q9HR76", "sequence": "MSERTASQPNTDRSRRRLRVVLDVALSDAAACPLEEIDGEVTAVRHQYTGDDCHADVTVAPACPDDDRSDVMHVATQTTDSCLCCVFSDHGCVPQITAVAADTITVETYLADRTTLTDLVADLKAVANTVSLTHLTRLAADDQSGDSHTHVTLDLFKLTDKQREAAAAAVAKGYYATPRGADLSDLATALGISKSAVSQRLSAVESKLATSAFTEAQQSAGSAP", "function": "Involved in activating dmsEABCD gene expression related to dimethyl sulfoxide (DMSO) reductase. Required for anaerobic respiration on dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO).", "AFDB_id": "AF-Q9HR76-F1-model_v4" }, { "swissprot_id": "P94131", "sequence": "MYSNNQRSRIGSHTWKIAFLFAFLALLVDGADLMLLSYSLNSIKAEFNLSTVEAGMLGSFTLAGMAIGGIFGGWACDRFGRVRIVVISILTFSILTCGLGLTQSFIQFGVLRFFASLGLGSLYIACNTLMAEYVPTKYRTTVLGTLQAGWTVGYIVATLLAGWLIPDHGWRVLFYVAIIPVLMAVLMHFFVPEPAAWQQSRLAPSKQTETVKTSAFKLIFQDKRNRNMFILWALTAGFLQFGYYGVNNWMPSYLESELGMKFKEMTAYMVGTYTAMILGKILAGFMADKLGRRFTYAFGAIGTAIFLPLIVFYNSPDNILYLLVIFGFLYGIPYGVNATYMTESFPTAIRGTAIGGAYNVGRLGAAIAPATIGFLASGGSIGLGFVVMGAAYFICGVIPALFIKEKQYDPQQS", "function": "Probable uptake of muconate.", "AFDB_id": "AF-P94131-F1-model_v4" }, { "swissprot_id": "Q8T0W2", "sequence": "MGFLACALLVVATAHAATAIVNPETCEIGSNFKNYCNNCYCFDGVMDHALCTRESCDRNVWNEDGTRKFPKPGKWISEKENKKNDEPCTPGENFKYYCNDCQCLDGLRAHAMCTRMRCDRNVFNEDGTRKYPEPEKWNSEKERKKSDESCAPGASFKYYCNSCTCGAEGKVAEAQCTSQECDRYKWKKDGSKRPFTLDPVLHD", "function": "Inhibits trypsin activity and prophenoloxidase (PPO) activation, an enzyme essential for both clotting and insect innate immune responses. It does not inhibit activity of chymotrypsin and protease K, and has no effect on phenoloxidase (PO) activity.", "AFDB_id": "AF-Q8T0W2-F1-model_v4" }, { "swissprot_id": "A0A1D3PCK2", "sequence": "MANKVKIGILNLMHDKLDTQSHFIKVLPNADLTFFYPRMHYQNRPIPPEVNMTSEPLDINRVSEFDGFIITGAPIDQIDFSKITYIEEIRYLLQALDNHKIQQLYFCWGAMAALNYFYGIKKKILAEKIFGVFPHLITEPHPLLSGLSQGFMAPHARYAEMDKKQIMQDERLAINAVDDNSHLFMVSAKDNPERNFIFSHIEYGKDSLRDEYNREINAHPERHYKKPINYSMSNPSFQWQDTQKIFFNNWLKKVKDNKLVLN", "function": "Transfers an acetyl group from acetyl-CoA to L-serine, forming acetyl-L-serine. In vitro, has also homoserine acetyl transferase activity.", "AFDB_id": "AF-A0A1D3PCK2-F1-model_v4" }, { "swissprot_id": "Q02596", "sequence": "MKFFTVLLFVSLAATSLALLPGSKDELQMKTQPTDAIPAAQSTPTSYTSEESTSSKDLSKEPSIFREELISKDNVVIESTKPENQEAQDGLRSGSSQLEETTRPTTSAATTSEENLTKSSQTVEEELGKIIEGFVTGAEDIISGASRITKS", "function": "Adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L-selectin.", "AFDB_id": "AF-Q02596-F1-model_v4" }, { "swissprot_id": "B4SGW9", "sequence": "MKFAIVVNVTRQNALDLARNLALWLDERKVAYIFESLSAEKLQTDNSAPIEELNKHCDAFISLGGDGTLLFTSHYAVTKPVIGVNVGYLGFLTEFTQAEMFTAIERVLNGSNTIHTRSQLDATVLIDNEVQHLRALNDVVIEKGAYPRIPTFIIKLDGELLSSYRADGIIIATSTGSTAYSMSAGGPIIAPKSSVFVITPICPHMLTVRPIVISDEKIIEVSVDAPDGSFPLNCDGNLKKMLDPQESITVRKSTVAINLVANENRDYCEILRTKLLWGREHNFGTIDS", "function": "Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.", "AFDB_id": "AF-B4SGW9-F1-model_v4" }, { "swissprot_id": "Q51D88", "sequence": "MACELKEFLVKNDMYPMGDQVEKKRKAISKMTEYIQQWGKKIYIESAGVADDTDVKAATIYVYGSYRLNVYGNNSDIDACIVSNSTITRDDFYDGLYAELLNNPDVKELKQIPSKRSPHLSMIYLNIEFDLNFSRTAYTSLPDNLDILNENILKNMDELDTRAINGVRNTDIIDAFVPNHSEEAFRVMVRTIKLWTKKRGIYGYVYCFLNGISIEILVAQVISENYQLDNVRLLEKFFQVYSSWDWLRTPVMLGTNDDFNDKKKEGVIQILTPASPSENAAFSITKFSLEMIKRELKRGQEIVHEFSSEGVNDWAKLFKPRHLFCGYYIFIEFIVTSSSLEGLTTTIGKFESGLVNLMKGLSEIEEIIEANVIPNGFLDEENEKYFYYVGMNVKRDCPVDISTPLNSFLSIVNSGKDLIVDASIKKRSEIPTKFAHSVKRSITKSQEIKETSSQVPSSAITETFDIPTKPSIEQQLKAKEENSIPNEEKKEQLKKEMKQEANTIVKNSSTDDDFMKRFTRKN", "function": "Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor.", "AFDB_id": "AF-Q51D88-F1-model_v4" }, { "swissprot_id": "Q45710", "sequence": "MDCNLQSQQNIPYNVLAIPVSNVNALVDTAGDLKKAWEEFQKTGSFSLTALQQGFSASQGGAFNYLTLLQSGISLAGSFVPGGTFVAPIVNMVIGWLWPHKNKTADTENLIKLIDEEIQKQLNKALLDQDRNNWTSFLESIFDTSATVSNAIIDAQWSGTVDTTNRQQKTPTTSDYLNVVGKFDSADSSIITNENQIMNGNFDVAAAPYFVIGATLRLSLYQSYIKFCNSWIDAVGFSTNDANTQKANLARTKLTMRTTINEYTQRVMKVFKDSKNMPTIGTNKFSVDAYNVYVKGMTLNVLDMVAIWSSLYPNDYTSQTAIEQTRVTFSNMVGQEEGTDGTLKIYNTFDSLSYQHSLIPNNNVNLISYYTDELQNLELAVYTPKGGSGYAYPYGFILNYANSNYKYGDNDPTGKPLNKQDGPIQQINAATQNSKYLDGETINGIGASLPGYCTTGCSATEQPFSCTSTANSYKASCNPSDTNQKINALYAFTQTNVKGSTGKLGVLASLVPYDLNPKNVFGELDSDTNNVILKGIPAEKGYFPNNARPTVVKEWINGASAVPFYSGNTLFMTATNLTATQYKIRIRYANPNSDTQIGVLITQNGSQISNSNLTLYSTTDSSMSSNLPQNVYVTGENGNYTLLDLYSTTNVLSTGDITLKLTGGNQKIFIDRIEFIPTMPVPAPTNNTNNNNGDNGNNNPPHHGCAIAGTQQLCSGPPKFEQVSDLEKITTQVYMLFKSSSYEELALKVSSYQINQVALKVMALSDEKFCEEKRLLRKLVNKANQLLEARNLLVGGNFETTQNWVLGTNAYINYDSFLFNGNYLSLQPASGFFTSYAYQKIDESTLKPYTRYKVSGFIGQSNQVELIISRYGKEIDKILNVPYAGPLPITADASITCCAPEIDQCDGGQSDSHFFNYSIDVGALHPELNPGIEIGLKIVQSNGYITISNLEIIEERPLTEMEIQAVNRKDQKWKREKLLECASVSELLQPIINQIDSLFKDANWYNDILPHVTYQTLKNIIVPDLPKLKHWFIDHLPGEYHEIEQKMKEALKHAFTQLDEKNLIHNGHFATNLIDWQVEGDARMKVLENNALALQLSNWDSSVSQSIDILEFDEDKAYKLRVYAQGSGTIQFGNCEDEAIQFNTNSFVYKEKIIYFDTPSINLHIQSEGSEFVVSSIDLVELSDDE", "function": "Promotes colloidosmotic lysis by binding to the midgut epithelial cells of insects.", "AFDB_id": "AF-Q45710-F1-model_v4" }, { "swissprot_id": "P23790", "sequence": "MLPSNQAGVAGSGRGLGLARRAGNGAGCPGIRGPGGQYSGSSGSSESGEEEDPPGRGIKRGLNELELPEQGGAAGVVGYPGASGTVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPSTDQRMSATGFEETDLTYQVSESDSSGETKDSLKPAFTVTNLPGTSNIQTVPTTSTSMQVSSGHSFPITNYLAPVTSANGTVLKTEGGAMSSGGLMQIPAGFTLMSAGGAVAQQVPVQAIQVHSAAQASPSSDSSSELVQTSSSGTVTLPAAIMTSSVPTTVSGHMMYPSPHAVMYAPTQGLTDGGLAVLNAFSSAPQMQVSHTQEQGGVQQVFLTAPPGTVQIPVSAVQLHQMTVIGQQSSGSNLTELQVVNLDTSNSNKND", "function": "SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration.", "AFDB_id": "AF-P23790-F1-model_v4" }, { "swissprot_id": "Q6S591", "sequence": "MRHEENYLDLNNLPDDFSKDGNKQALEEGSSSGQRKKKGSKEGKDESGKVYECRFCSLKFCKSQALGGHMNRHRQERETETLNQARQLVYRNDTITPPGISPFGYHHTTDPTIYRSVYSSPMIYPGSSSTNLVPQPPMPPPPPPYPYSSNQYSPHNHFNDYYLNPSFRGSRSISPSPNLPTTTTVDYMADSPVEPGYTCVGAPIGPTGFPIRGPSIVRAPLEPPQGRDGDASRQRLDHSLRFPINRFQDHHSL", "function": "Controls the morphogenesis of lateral organs. Functions in lateral organ shape and is sufficient to induce proliferation and growth of lateral organ tissue. Is necessary and sufficient for bract formation, but its expression is excluded from the cryptic bract, which could be a cause of bractless flowers in Arabidopsis. Participates with FIL and YAB3 in regulating valve margin development. Functions with JGL to define stamen and carpel shape. Functions with AS1 and AS2 in the sepal and petal primordia to repress boundary-specifying genes for normal development of the organs.", "AFDB_id": "AF-Q6S591-F1-model_v4" }, { "swissprot_id": "O34712", "sequence": "MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATIIIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDAHYAGVELEKLHEWIKEISADVKGGKKND", "function": "Negatively regulates ABC transporter complex ytrBCDEF that plays a role in acetoin utilization during stationary phase and sporulation.", "AFDB_id": "AF-O34712-F1-model_v4" }, { "swissprot_id": "Q12199", "sequence": "MSKRNTPPLRSSGINTIQINAAREMHAQTVRARRMPMPTSGITTPSVQPTAAPATPPRHICNNPNNPQCLHCGSVIIPSPRATLPLEDNPSISINDWTISSRKKPILNSQELDIWENEKLKGLTLPEMIFGNNYIRIENSKQHWSIEFNALDALKEVQLQDSGIRVAYSNDWINSKKRQNSTNGAQRFTNDVNDDSLNIIHKYDWTYTTRYKGTESSPESKFRLDNDQKLPLDKLAVHDKILFYDDMILFEDELADNGISILNVKIRVMNERLLLLSRFFLRVDDVLVRVYDTRIYVEFDENVVIRESKEFEGKYQDVLAKHRLSQSHDPKAALRDSNWVAQNTPMIKRQCEIIQF", "function": "Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Indirectly activates the PP2A phosphatase SIT4 via interaction with its suppressor TAP42. This interaction is enhanced under nitrogen limitation conditions. Also has a role in regulation of NPR1 in response to nitrogen limitation.", "AFDB_id": "AF-Q12199-F1-model_v4" }, { "swissprot_id": "Q42369", "sequence": "MARNMAHILHILVISLSYSFLFVSSSSQDSQSLYHNSQPTSSKPNLLVLPVQEDASTGLHWANIHKRTPLMQVPLLLDLNGKHLWVTCSQHYSSSTYQAPFCHSTQCSRANTHQCFTCTDSTTTRPGCHNNTCGLLSSNPVTQESGLGELAQDVLAIHSTHGSKLGPMVKVPQFLFSCAPSFLAQKGLPNNVQGALGLGQAPISLQNQLFSHFGLKRQFSVCLSRYSTSNGAILFGDINDPNNNNYIHNSLDVLHDLVYTPLTISKQGEYFIQVNAIRVNKHLVIPTKNPFISPSSTSYHGSGEIGGALITTTHPYTVLSHSIFEVFTQVFANNMPKQAQVKAVGPFGLCYDSRKISGGAPSVDLILDKNDAVWRISSENFMVQAQDGVSCLGFVDGGVHARAGIALGAHHLEENLVVFDLERSRVGFNSNSLKSYGKTCSNLFDLNNP", "function": "Sulfur-rich seed storage protein that remains undegraded at germination.", "AFDB_id": "AF-Q42369-F1-model_v4" }, { "swissprot_id": "Q8N841", "sequence": "MPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGCERS", "function": "Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions. Mediates microtubule polyglutamylation in primary cilia axoneme, which is important for ciliary structural formation and motility. Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating. Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response.", "AFDB_id": "AF-Q8N841-F1-model_v4" }, { "swissprot_id": "Q8GZ42", "sequence": "MIIKRKLKTLKRCNSTNEEDDIVRKKRKVNLNGGGSGGDYYYPLNLLGEIGAGIVPGKNGFSVSLCKQVSCSPKVEVVEEEEEEEEIKSTRLVSRPPLVKTSRGRVQVLPSRFNDSVIENWRKDNKSSGEEREEEIEEEACRKEKVKVSSNHSLKIKQQETKFTPRNYKYSSSSALCGEIDDEDKCEEIVRYGNSFEMKKQRYVDDEPRPKKEGVYGPEDFYSGDLVWGKSGRNEPFWPAIVIDPMTQAPELVLRSCIPDAACVMFFGHSGTENERDYAWVRRGMIFPFVDYVERLQEQSELRGCNPRDFQMALEEALLADQGFTEKLMQDIHMAAGNQTFDDSVYRWVEEAAGSSQYLDHVAPSQDMKKYRNPRACVGCGMVLSFKMAQKMKALIPGDQLLCQPCSKLTKPKHVCGICKRIWNHLDSQSWVRCDGCKVWIHSACDQISHKHFKDLGETDYYCPTCRTKFDFELSDSEKPDSKSKLGKNNAPMVLPDKVIVVCSGVEGIYFPSLHLVVCKCGSCGPERKALSEWERHTGSKAKNWRTSVKVKSSKLPLEEWMMKLAEFHANATAAKPPKRPSIKQRKQRLLSFLREKYEPVNVKWTTERCAVCRWVEDWDYNKIIICNRCQIAVHQECYGTRNVRDFTSWVCKACETPEIKRECCLCPVKGGALKPTDVETLWVHVTCAWFQPEVCFASEEKMEPALGILSIPSSNFVKICVICKQIHGSCTQCCKCSTYYHAMCASRAGYRMELHCLEKNGRQITKMVSYCSYHRAPNPDTVLIIQTPSGVFSAKSLVQNKKKSGTRLILANREEIEESAAEDTIPIDPFSSARCRLYKRTVNSKKRTKEEGIPHYTGGLRHHPSAAIQTLNAFRHVAEEPKSFSSFRERLHHLQRTEMERVCFGRSGIHGWGLFARRNIQEGEMVLEYRGEQVRGIIADLREARYRREGKDCYLFKISEEVVVDATEKGNIARLINHSCMPNCYARIMSVGDDESRIVLIAKTTVASCEELTYDYLFDPDEPDEFKVPCLCKSPNCRKFMN", "function": "Histone methyltransferase.", "AFDB_id": "AF-Q8GZ42-F1-model_v4" }, { "swissprot_id": "P14774", "sequence": "MMNRVKIGTALLGLTLAGIALPALAQPQSGPQTGVVFRNTVTGEALDVSQGKEGGRDTPAVKKFLETGENLYIDDKSCLRNGESLFATSCSGCHGHLAEGKLGPGLNDNYWTYPSNTTDVGLFATIFGGANGMMGPHNENLTPDEMLQTIAWIRHLYTGPKQDAVWLNDEQKKAYTPYKQGEVIPKDAKGQCKPLDE", "function": "Electron acceptor for MDH. Acts in methanol oxidation.", "AFDB_id": "AF-P14774-F1-model_v4" }, { "swissprot_id": "Q9VRP9", "sequence": "MSKRSADDATGSSCLVAAAAAGQPPIKKVHFEPHLIGPVSTLEEMDIKVLEFQNKKLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETADELENRNENEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIVQVIDRLMQRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQKELEEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYLQ", "function": "E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes.", "AFDB_id": "AF-Q9VRP9-F1-model_v4" }, { "swissprot_id": "Q9FHM4", "sequence": "MASVQKDPILQVETTCGSLLFELQIIWDEVGETETDRDQMLLELERECLEVYRRKVDQANRCRAQLRQAIADAEAQLAAICSAMGERPVHIRQSDQSVGSLKQELGRILPELEEMQKRKVERRNQFIVVMEQIDSITNDIKGQGELVHSEPLIDETNLSMRKLEELHCQLQVLQKEKIDRVETIRKHLCTLYSHCSVLGMDFNEVVGQVNPTLSDPEGPRSLSDHTIEKLGAAVQKLMEVKIQRMQRLQDLATTMLELWNLMDTPIEEQQEYQHITCNIAASEHEITEANSLSEDFIKYVEAEVVRLDEVKASKMKELVLKKRSELEEICRKTHLLPVSDSAIDQTIVAIESGIVDATMVLEHLEQHISKIKEEALSRKEILERVEKWLSACDEESWLEEYNRDDNRYNAGRGAHLTLKRAEKARNLVTKLPGMVEALASKTIVWEQENGIEFLYDGIRLLSMLEEYNILRQEREEEHRRQRDQKKLQGQLIAEQEALYGSKPSPSKPLGGKKAPRMSTGGASNRRLSLGAAMHQTPKPNKKADHRHNDGALSNGRRGLDIAGLPSRKQSMNPSEMLQSPLVRKPFSPISTTVVASKANIATTTTQQLPKNNAVNEISSFATPIKNNNILRNLEEEKMMTMMMQTPKNVAAMIPIPSTPATVSVPMHTAPTPFTNNARLMSEKPEVVEYSFEERRLAFMLQSECRLV", "function": "Microtubule-associated protein that plays a critical role in organizing the mitotic microtubule array during both early and late mitosis in all plant organs. Essential for the cytokinesis, especially in roots, by maintaining the integrity of the overlapped microtubules in the phragmoplast. Required during root morphogenesis. Needed for giant cell development during root knot nematode infection, where cytokinesis is initiated but not completed.", "AFDB_id": "AF-Q9FHM4-F1-model_v4" }, { "swissprot_id": "P31875", "sequence": "MENRANTEGTFERELEFTALTRWFHWIRAIAIFVLIVTGFYIAYPFLTPIKNSEPTNFMYALARSWHQIFGFALIAVTIFRVYLFIFDKGCRVERASFWDLINPLTWFRQLRNYMLLGPHPHLKGVYNPVQLAAYMGLMVLILLISVTGIILYYNVYHDGLGAILFAIFKPLEVMFGGLANVRAIHHITTWAFVIFIPVHIYMATWNSARYPNGGIDSIFSGFRYHKKHY", "function": "B-type cytochrome that interacts with quinones and anchor the hydrogenase to the membrane.", "AFDB_id": "AF-P31875-F1-model_v4" }, { "swissprot_id": "I1S490", "sequence": "MPTPVESHSLLHSGLTLCGSIISVNQDRRKTSTLGCVIQVGSGFYGLTAAHAVRKSRAYPTLPLNSHTDEGLGAASDGPMTSHVLRNWQNPFMACKNAEAVELDDHSTSEVAVDESVEDVDFVTDVEYEDLREDDDNHGDDSTTSMPNDVFHEDYLTSAPQEGMMETQAMFLSIPELNDKCLVSRRARPNMAHRVTHGDSGSIVIDARTNVVYGHVVASNPLGEIYISPIGATLEQIQSHFPGSKVSLPDPLTILTGLATFGHETIGRKRARYPDKLRNLGLSPDTEYTRLVTPTANKSLDFSNYPKFHYFHQCSEDSSSNRRVNEVEKSQPANLTLDCNTVELGLRQSTWHQADSPVPLSSVKEESGLGKLARSPAEPAPSRPLPGSSIPVVISQSTGRELYSNGVTEATLSSKLSDEAEADTSIKPDSDAASPTDCRIIGHLRTRPVGLERDLSSTYNAALSMDQDPEELLQQDIFPMRVWRSLSTLKQRLPSQERLENLTWRMTHINLRKPKEQEEPKRHRTSNNSIVGSSDIADVGKTSKQKAIQPNIVELDVVTSPENIPLPASLVPISSSEATWQVDKKSVSSVTFGQSSGCFPPSYQGFRPDAPEKGNLPRATTTSYHLPPQPIGWPTCIPSNMKWHSLVNMSTLAADEHEGEGRADTNRHVSTQSNMPTEQSLLPQGDESVPPTCTNCFTLTCDILARNENVDQLAIDAPGHITSAKAVYNLYTFISYLLIF", "function": "Part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves. The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).", "AFDB_id": "AF-I1S490-F1-model_v4" }, { "swissprot_id": "Q3MIX3", "sequence": "MWRPVQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPTPLWRKVLSTAVVGAPLLLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVPPAEELYQYLET", "function": "The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).", "AFDB_id": "AF-Q3MIX3-F1-model_v4" }, { "swissprot_id": "K0E4D9", "sequence": "MDDSPWPQCDIRVQDTFGPQVSGCYEDFDFTLLFEESILYLPPLLIAASVALLRIWQLRSTENLLKRSGLLSILKPTSTTRLSNAAIAIGFVASPIFAWLSFWEHARSLRPSTILNVYLLGTIPMDAARARTLFRMPGNSAIASIFATIVVCKVVLLVVEAMEKQRLLLDRGWAPEETAGILNRSFLWWFNPLLLSGYKQALTVDKLLAVDEDIGVEKSKDEIRRRWAQAVKQNASSLQDVLLAVYRTELWGGFLPRLCLIGVNYAQPFLVNRVVTFLGQPDTSTSRGVASGLIAAYAIVYMGIAVATAAFHHRSYRMVMMVRGGLILLIYDHTLTLNALSPSKNDSYTLITADIERIVSGLRSLHETWASLIEIALSLWLLETKIRVSAVAAAMVVLVCLLVSGALSGLLGVHQNLWLEAMQKRLNATLATIGSIKGIKATGRTNTLYETILQLRRTEIQKSLKFRELLVALVTLSYLSTTMAPTFAFGTYSILAKIRNMTPLLAAPAFSSLTIMTLLGQAVSGFVESLMGLRQAMASLERIRQYLVGKEAPEPSPNKPGVASTEGLVAWSASLDEPGLDPRVEMRRMSSLQHRFYNLGELQDGLIVLQNHTASWEKASKPVLTDINVTITRGSFVIVIGPIGSGKSTLLHSILGEVPHTTGIRTIQEVDTAFCAQTPWLTNTNVRDNILGASHFDPAWYNAVVKACALHRDFAQLPHGDRSMIGSKGILLSGGQKGRLALARALYARKALLVLDDVFAGLDPKTGQEVFTSLFGARGLLRQGKTTTVLATNSTQNLSMADYIMVLGSEGRLIEQGTPTELLNSGSSLRLEELVKTREGKSKAEPERERPEYARALRNSVLGATPVAARRRFSDMAIYKLYIRTIGWGSWWIFIVLCSGFVVALTLSRENTLALPSACAGVDLLTACLEEIWLKFWTEANARNPHDRLGYYLSLFAVWSALAITFFLGACLHLMLRMVPKAAKIFHGSLLQTVMRAPLVFFSKTDSGEISNHFSQDLELIDMELPRALIGAVIALILCISAMAVIVYSSNYLAATIPGLLGLLYLVQMFYLRTSQQLRVLELETRAPLLSHYMETIQGLVSLRAFGWSKHFKDRHHGHLKVAQQSAYLLFCAQIWLTLTLDIIVAFLAIILVSIAVTVKNSSAASIGLALVNLIAFGANMKGLVYNWTALENAMGAIARVRDFTTETPCEIQVGESHSPSPGWPQRGLIKFKSVTASYDFTSHPVLNDVTFTVQPGEKLAICGRTGCGKSSLVSSLLRLLEVRNGAIEVDGIDISTLSREDVRMSLNVLPQEPFFYHGTIRQNLDPNCLSSDEEILETLALLGLREVISKKGGLDVAMDDGFLSHGQQQLLCLARAILKKSRILILDEVTSSVDQETETLITRVLRDRLQDQTVISIAHRLNTIMDYDKVIILDKGCIVEQGNPQVLALQRSIFASLLRSGDEEPGNGHKHESEGEEE", "function": "ABC transporter; part of the gene cluster that mediates the biosynthesis of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent.", "AFDB_id": "AF-K0E4D9-F1-model_v4" }, { "swissprot_id": "Q54PB4", "sequence": "MPSNPNRSIYDFYNITDIIGEGTFSTVTLANHIEKIEDKYAIKIISKEVLDNERRTYVDWEISILSKCQHPNIIKFYEHYESDEDICLVLEWIPNGDLFDRIVKKGVFNEEEARLTMKSLLSAVEYLHDKSVVHRDIKPENILFSDSYGGIKLGDFGLAKFYEESIGLELACGTLAYSAPEITNNQVYRKSVDMWSCGCILYFILFGRPPFYSDDESEMFELITKGQWEFPSKTQHKYSDQVKDLIKLLLENDPNKRLTVKQSLAHKWIQSIDERSFSSVIKQSPLITSQQQQQQSPSSLLSSSSSSTASSPSLKPLSPLVAIIEQQEYNYNHQQLQNHNILHSSNSHSRHHHASSANSTTVDQQQEEDNNHHYHRHNSNNNINNNNDNNDNNNSNSNNSNNNINNFINNNNNNNNNNSNFFDDDDEIDINQNEMDDIDDEQQQPTNSLRSSSKPIAIKKSQIRTSLNGNIDIKRGVLTPL", "function": "May phosphorylate a specific serine in the N-terminus of a myosin light chain.", "AFDB_id": "AF-Q54PB4-F1-model_v4" }, { "swissprot_id": "P05226", "sequence": "MFKGILLCVLFAVLSANPLSQPEGFADEEERDVRGLASLLGKALKAALKIGANALGGSPQQREANDERRFADGQQDYTGWMDFGRRDDEDDVNERDVRGFGSFLGKALKAGLKIGTHFLGGAPQQREANDERRFADGQQDYTGWMDFGRRDGQQDYTGWMDFGRRDDEDDVHERDVRGFGSFLGKALKAALKIGANALGGSPQQREANDERRFADGQQDYTGWMDFGRRNGEDD", "function": "The pharmacological activities of caerulein are quite similar to the physiological activities of gastrin and related peptides.", "AFDB_id": "AF-P05226-F1-model_v4" }, { "swissprot_id": "A0A0T7AQA7", "sequence": "MNTPPFVCWIFCKVIDNFGDIGVSLRLARVLHRELGWQVHLWTDDVSALRALCPDLPDVPCVHQDIHVRTWHSDAADIDTAPVPDAVIETFACDLPENVLHIIRRHKPLWLNWEYLSAEESNERLHLMPSPQEGVQKYFWFMGFSEKSGGLIRERDYRDAVRFDTEALRQRLMLPEKNAPEWLLFGYRSDVWAKWLEMWQQAGSPMTLLLAGAQIIDSLKQSGIIPQNALQNDGDVFQTASVRLVKIPFVPQQDFDQLLHLADCAVIRGEDSFVRAQLAGKPFFWHIYPQDEHVHLDKLHAFWDKAHGFYTPETASAHRCLSDDLNGGEALSATQRLECWQILQQHQNGWRQGAGAWSRYLFGQPSASEKLAAFVSKHQKIR", "function": "Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys-32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes.", "AFDB_id": "AF-A0A0T7AQA7-F1-model_v4" }, { "swissprot_id": "Q93LK7", "sequence": "MKRWILFLILSVFLIGCAKTKIVDDIDLVQVAAYDTEAEGKLKGTFAISAYKGGGEGETKIYSASGQTGREVLARASEKSSGPLELGQLRVIIFNEKIIEKGMQEILETLNRNPSVGNAIYLAITNVKGESLLKGNYSKEKEIASYLSSLLEQNMNNGTQPKTNFFMFLNQLDDDARDSYLPMISKKGNVLELNGIALFKRCKMVDKVNPKDLFVFKLLTDNFKQGTYQFKLPGSSNTYATIENIKARTKYKMEGNSKHPFVNAHIQVKAEIQEFTKTKNLDNPKEIKKLEKIMGKEIEKKATTLIKRFIKKDTDPIGLRKLGRTHVRKWNSQEWEESYKHLRFRVTADVKVTQSGVTE", "function": "Required for the germination response to inosine. Has no role in L-alanine germination.", "AFDB_id": "AF-Q93LK7-F1-model_v4" }, { "swissprot_id": "C0CMQ7", "sequence": "MGKIVVSVIGAGGKMGTRTSNNLAKKPEEFDLLLVEASEAGIQSIKDRGFEPTPVEEALEKSDVVVFAVPDTLIGKLSAIYVPQLKPGTGFIILDPAAAVARELTLRDDCTFGVAHPCHPSYFLDQDTYEARQDRFGGCGGKQDIVMSKIQGNDDRFAQCVEVAKQMYAPVEHAYVMSSEQIAFLEPTLVELLGATCLYAMAETVDEAVKRGIPKEAAVSFLTGHIYNLSANFLGYIPGNPPVSDACKVAIGLGNRLVMREDWKKIWDDEVLNKVIATMLHPDKPQI", "function": "Involved in catabolism of D-apiose. Catalyzes the conversion of D-apionate to 3-oxo-isoapionate.", "AFDB_id": "AF-C0CMQ7-F1-model_v4" }, { "swissprot_id": "P40480", "sequence": "MNETTTKQPLKKRSLSSYLSNVSTRREELEKISKQETSEEEDTAGKHEQRETLSEEVSDKFPENVASFRSQTTSVHQATQNNLNAKESEDLAHKNDASSHEGEVNGDSRPDDVPETNEKISQAIRAKISSSSSSPNVRNVDIQNHQPFSRDQLRAMLKEPKRKTVDDFIEEEGLGAVEEEDLSDEVLEKNTTEPENVEKDIEYSDSDKDTDDVGSDDPTAPNSPIKLGRRKLVRGDQLDATTSSMFNNESDSELSDIDDSKNIALSSSLFRGGSSPVKETNNNLSNMNSSPAQNPKRGSVSRSNDSNKSSHIAVSKRPKQKKGIYRDSGGRTRLQIACDKGKYDVVKKMIEEGGYDINDQDNAGNTALHEAALQGHIEIVELLIENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGADPTIRNAKGLTAFESVDDESEFDDEEDQKILREIKKRLSIAAKKWTNRAGIHNDKSKNGNNAHTIDQPPFDNTTKAKNEKAADSPSMASNIDEKAPEEEFYWTDVTSRAGKEKLFKASKEGHLPYVGTYVENGGKIDLRSFFESVKCGHEDITSIFLAFGFPVNQTSRDNKTSALMVAVGRGHLGTVKLLLEAGADPTKRDKKGRTALYYAKNSIMGITNSEEIQLIENAINNYLKKHSEDNNDDDDDDDNNNETYKHEKKREKTQSPILASRRSATPRIEDEEDDTRMLNLADDDFNNDRDVKESTTSDSRKRLDDNENVGTQYSLDWKKRKTNALQDEEKLKSISPLSMEPHSPKKAKSVEISKIHEETAAEREARLKEEEEYRKKRLEKKRKKEQELLQKLAEDEKKRIEEQEKQKVLEMERLEKATLEKARKMEREKEMEEISYRRAVRDLYPLGLKIINFNDKLDYKRFLPLYYFVDEKNDKFVLDLQVMILLKDIDLLSKDNQPTSEKIPVDPSHLTPLWNMLKFIFLYGGSYDDKKNNMENKRYVVNFDGVDLDTKIGYELLEYKKFVSLPMAWIKWDNVVIENHAKRKEIEGNMIQISINEFARWRNDKLNKAQQPTRKQRSLKIPRELPVKFQHRMSISSVLQQTSKEPFW", "function": "Unknown. Component of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis.", "AFDB_id": "AF-P40480-F1-model_v4" }, { "swissprot_id": "Q7KQJ9", "sequence": "MFECRIDGQFFKKLFETLKDICTEVNLECDENGIKMQSMDCSHVSLVDLNIVSDFFQHYRCDKNCVLGISINFMLKILSVIKEKSTVFLFKEDNENDAVLNIGIIDEEEQSSADDSLEIQVKLINAQKEHLEIPQSEYHCQCTMKSKKFQEFTKYLNSIGDNVSISMKKDAMILSTTGSDIKVTKQFTNDMTDISITCTKSVSQEFATRYLVMFSRASSLSDEVLISLSPHIPISIKFNFKQQLTDLQDPSHLTFFLAPKIGDY", "function": "May be involved in DNA damage response. Appears not to be involved in DNA replication in trophozoites.", "AFDB_id": "AF-Q7KQJ9-F1-model_v4" }, { "swissprot_id": "O50657", "sequence": "MKNFRLSEKEVKTLAKRIPTPFLVASLDKVEENYQFMRRHLPRAGVFYAMKANPTPEILSLLAGLGSHFDVASAGEMEILHELGVDGSQMIYANPVKDARGLKAAADYNVRRFTFDDPSEIDKMAKAVPGADVLVRIAVRNNKALVDLNTKFGAPVEEALDLLKAAQDAGLHAMGICFHVGSQSLSTAAYEEALLVARRLFDEAEEMGMHLTDLDIGGGFPVPDAKGLNVDLAAMMEAINKQIDRLFPDTAVWTEPGRYMCGTAVNLVTSVIGTKTRGEQPWYILDEGIYGCFSGIMYDHWTYPLHCFGKGNKKPSTFGGPSCDGIDVLYRDFMAPELKIGDKVLVTEMGSYTSVSATRFNGFYLAPTIIFEDQPEYAARLTEDDDVKKKAAV", "function": "Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency.", "AFDB_id": "AF-O50657-F1-model_v4" }, { "swissprot_id": "O35885", "sequence": "MEAHLDWYGVPGLQEASDACPRESCSSALPEAREGANVHFPPHPVPREHFSCAAPELVAGAQGLNASLMDGGALPRLMPTSSGVAGACAARRRQASPELLRCSRRRRSGATEASSSSAAVARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETLRSAVEYIRALQRLLAEHDAVRAALAGGLLTPATPPSDECAQPSASPASASLSCASTSPSPDRLGCSEPTSPRSAYSSEESSCEGELSPMEQELLDFSSWLGGY", "function": "AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.", "AFDB_id": "AF-O35885-F1-model_v4" }, { "swissprot_id": "Q9M1Y1", "sequence": "MGVSKKKSGEIRGDLIPGLPEELAIECLVRVPFQFHSSIKSVCRSWKCVISSRSFIKERIGFGKAESLLCLVQPLTSPPSPAMMEGGEMSQKKKEEEEGESQMTQQLLQPRITGTPLYGLSVYNATLDTWHRVAIPERIPLFCECVAIQDAGKVLLIGGWDPETLQPVRDVFVLDFFAGEGSGRRFRRGRPMSAARSFFACASVGSTKVYVAGGHDDQKNALRSAEVYDVEKDEWSMLPPMTEGRDECHGFSMATDPGFCVLSGYGTETQGQFRSDGEIYDPITNSWSTIENVWPFPDLSPRGRTAAAAAEFPGDFRGCRLWCFIDSERQSQPHWEVEDDSMKWKVIMDTIRLPVTTMTSVFAGSLSGQAVAMIGGGGEESGTMMVKTTAEKNGGKWSHVNTPSGFSSLPFSCSSIYV", "function": "Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q9M1Y1-F1-model_v4" }, { "swissprot_id": "Q0CJ62", "sequence": "MTFSNRVSVAIIGGGIGGLSLAIGLLQNKNLDVAIYETAPKFAEIGAGVALGPNAQHALALISPAAEHAFRIHATTSLSPEFEHVWFDFRNGNAGEKDGEVLSKVENETGQQTVHRAKFLDELVKLIPREIAHFGKRLIHIQKDPVSGGAQYKLFFEDGTTASADCVIGADGIHSSVRKHLLGESHPAATPVFTGTVVYRGLIPMDVARDAIGEFADNSYMWCGDGGMVMTYPIDHGETLNVVGTRNDKGRWDGPPYTRPVDEETVRNDFMGWGEIPSKVIQPTMWAILDHYPAPYYYSGNVAIMGDAAHATTPFQGAGAGQAIEDALVLSTLFQRVTHSGLVRPALAAYNNVRLRRTQKVVATSRDALRLFCFNDRYVDGDAQRWREVWNGRMDWLWGMDLEKQNRDAVNLFADIVEKQSSARETMPKFGPVPFPVATSTV", "function": "6-methylsalicylic acid decarboxylase; part of the gene cluster that mediates the biosynthesis of terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the 6-methylsalicylic acid synthase atX. In the biosynthesis of 6-MSA, atX utilizes one acetyl-CoA and three malonyl-CoAs as its substrates and catalyzes a series of programmed reactions including Claisen condensation, dehydration, reduction, and cyclization to yield 6-MSA. The 6-methylsalicylic acid decarboxylase atA then catalyzes the decarboxylative hydroxylation of 6-MSA to 3-methylcatechol. The next step is the conversion of 3-methylcatechol to terremutin via several oxidation steps involving the cytochrome P450 monooxygenase atE and probably also the cytochrome P450 monooxygenase atG. Lastly, atC is required for the oxidation of terremutin to terreic acid. No function could be assigned to atD yet, although it is involved in the biosynthesis of terreic acid.", "AFDB_id": "AF-Q0CJ62-F1-model_v4" }, { "swissprot_id": "P35149", "sequence": "MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLPNISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYTVPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDIARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVESMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRLRDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRDHLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVRLKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLSSIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL", "function": "ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Its ATP hydrolysis is required for proper assembly of the spore coat. Forms a basement layer around the outside surface of the forespore and self-assembles irreversibly into higher order structures by binding and hydrolyzing ATP thus creating a durable and stable platform upon which thereafter morphogenesis of the coat can take place. Required for proper localization of spore coat protein CotE and sporulation-specific proteins including SpoVM.", "AFDB_id": "AF-P35149-F1-model_v4" }, { "swissprot_id": "Q9FJ57", "sequence": "MESEPDQSFKDLSWFLQAIKDPQQTFFNLQTLSFSSSGNTTHCQLITESSMNINVTRDNLTSLSQIFIELATSLETQTSLRNLEFEGIFWEIELLQSLGLLLDNTSKIKQLAFRKNRFSEQCLNELSEILKRNRFLKEVMFLESSIGYRGATLLGSALQVNDSLEELQIWEDSIGSKGAEELSRMIEMNSSLKLFSIFDSSPFTATPLISAVLGMNREMEVHMWSGDHKRDRSLKLVEFLPESKTLRIYQIDISGSCRVAAALGMNTTVRSLDMTGAKLNSRWAKEFRWVLEQNKTLREVKLSKTGLKDKAVVYIAAGLFKNKSLQSLYVDGNRFGSVGVEDLLCPLSRFSALQLQANITLRSIVFGGSNTKIGRDGLTAVLKMVTTNETVVHLGIHDDASLGPDDFIHIFKSLQKNASLRRFSLQGCKGVRGDRVLEAITETLQINPLIEEIDLARTPLQDSGKADEIYQKLGHNGRKIDEAETDDSLKDMPLTEPKSVRAFLCGQNYAGKTTLCNSILQSSSASGFPYVENVRNLMNPVEQVVKTVGGMKIKTFKDEETKISMWNLAGQHEFFALHDLMFPSPCFFLIVLSLFRKPSNKEPKTPAEVEEELEYWLRFIVSNSRKAIQQCMKPNVTIVLTHSEKINLQSESFQATVGCIQRLRDKFQALVEFYPTVFTVDARSSPSVSKLTHHIRMTSKAILQRVPRVYQLCNDIVQLLSDWRSENSNKPIMRWKAFADLCQFKVPSLRIKSRNENIQIVETRRHAIATCLHQMGEVIYFDDLGFLILDYEWFCGEVLTQLIKLDVRKQSTGERNGFVSRKELEKTLRSSLQSPIPGMTSKVLEHFDACDLVKMMKKVELCYEQDPSSPDSSLLVPSILEEGRGKTQKWQINTHDCVYSGRHLQCDDSSHMFLTAGFFPRLQVHLHNRIMELKNQHGATYSLEKYLIAITIHGINIRVELGGQLGNYIDVLACSSKSLTETLRLIHQLIIPAIQSSCRGVILLEHIIRPQCVQDLTPPRFRQSQFVSLHRLKEALSSVPAETMYDYQHTWDSVLDSGKTVLRAGFDLARNLLSDDDFREVLQRRYHDLHNLAQELQVPTDENPEADNHVPVTNELEKVDPSFGGIAKGVEAVLQRLKIIEQEIRDLKQEIQGLRYYEHRLLIQLHHKVNYLVNYNVQMDERKVPNMFYFIRAENYGRRLITSMVPGMVALRIHMLCEFRREMHVVEDQLGCDVMQIDNQAVKCLAPYMTNFMKLVTFALRIGANWAAGMGHMIPDLSHTIAHLANPAVMTGAAGAAGAIGVAAALGRNRGRDRDIQEQEQRAAQQWLIDYLREQTCSTGRDIAEKFGLWRVRYRDDGSIAWICKRHMITRAHEVIQVPL", "function": "Involved in the basipetal transport of auxin (IAA) that modulates growth and organs organization. Required for initial divisions in the epidermal/lateral root cap leading to the formation of epidermal cells and a clone of lateral root cap cells, as well as for the maintenance of the radial pattern of cell specification in the root, thus regulating the distinction between the lateral root cap and epidermis.", "AFDB_id": "AF-Q9FJ57-F1-model_v4" }, { "swissprot_id": "Q9LQX2", "sequence": "MATEQEAEVGTETSSVSGRFLRNRDLYLFLPFLLGFSDQESSNGDDDDVASSRERIILVNPFTQGMIVLEGSSGMNPLLRSLLESREEGRPPASKASIDAMPIVEIDGCEGECVICLEEWKSEETVKEMPCKHRFHGGCIEKWLGFHGSCPVCRYEMPVDGDEIGKKRNDGNEIWVRFSFNDGRRIRDFSAQDGGNSDGVESEN", "function": "E3 ubiquitin-protein ligase involved in protein quality control (PQC) under proteotoxic stress. Is essential to plant survival under proteotoxic stress. Functions by removing damaged proteins before they form cytotoxic aggregates. Recognizes misfolded proteins selectively and tethers polyubiquitin chains to the proteins directly for subsequent degradation by the 26S proteasome pathway. Targets misfolded proteins independently of cytoplasmic chaperones. Associates with the 26S proteasome and sustains the structural integrity of the proteasome complex at the initial stage of proteotoxic stress. Under normal conditions, MPSR1 becomes highly unstable by its autoubiquitination activity and is stabilized during proteotoxic stress by conjugating ubiquitins on misfolded proteins.", "AFDB_id": "AF-Q9LQX2-F1-model_v4" }, { "swissprot_id": "P47282", "sequence": "MCFNQRILIGSISTEQLNKTIVIIGWIKRIKKLGEINFIIVGDKSGTIQVTCKDKEQIQQLTREDIVIVKAKLQRLDSVRFELINPTIKLFSKSKTPPLIIEDETDALEEVRLKYRYLDLRRRLMQKRLLLRHQFILAIRNWFNQQGFIEIETPTLSKSTPEGAQDFLVPARIRKDCFYALVQSPQIYKQLLMIAGVEKYFQIARVYRDEDSRKDRQPEHTQIDFEISFCNQKMIMNLVEKLFFSVFLDVFQIKIKKTFPVFKFSELFERFGSDKPDLRYGFEIKDFTSLFQDHQNQFTKLIEAKGIIGGIELTNIELSTDKIKALRKIAKDHDVSLEVHNKNNSTLKTSIKCDEKNTLLLVANKSKKKAWTALGAIRNELKYHLDIVKPNQYSFCWVVDFPLYDFDEKTNQWISNHNIFSKPKQEWIDNFESNKNEALSEQFDLVLNGFEIGSGSIRINDPIVQKRLMNSLNIDPNKFAFLLEAYQYGAPVHGGMGLGIDRLMMILNQTDNIREVIAFPKNNHGIEVHTNAPDKIDKEEVKWWIKELVK", "function": "Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).", "AFDB_id": "AF-P47282-F1-model_v4" }, { "swissprot_id": "Q21029", "sequence": "MSQNNKRQVQHNHEMSNDVCPLPLPPRGAPPPTAYHASRMAATSSSTNGSFEKSAIPGNARKLHVVIVIDQKVQKNLRVREMALKDVQKVADTLNVNLTRIDFDKLDFGETETLDLFYNADVALVDVTVTHQQPSLCYHIGVRESMGQSYNMILTYWSPDPEYHIMDALKKTHAHLPMIVYIHHQDSNQLQSYDKNNNDDDSKPPFARTNVPAKTITFQHRMKQVLKSVQVEASAHSREKFMSDLRKAREITDGDQKNDYLDKMRTRLDNPDVLHPDTVSLMMLSYRDNQNYGGMIRLVDDLKRIPDCLKVVDTPVIRYQYAFALNRRNKDGDRDLALNTVLSLVEGTTENEEKNGPLSPDVVCLAGRIYKDKFIASNYEDRESLNSAIEWYRRAFEMSPLEYSGINLTTLLRASGEHFENNLEMQQIAVVLNSLLGRKGALQNLMEYWDVATYFEVSVLAENYQKACEAALMMVKLKPPVWYLKSTMENIKLINRCAATISPIEKEKQQFLFWSEFFMEATEADTDISCPRYPVLILELNKEFTPSYLTLNNEEGTVILSHVLENSQQKKIHQSELRGIHRWHFARNNIKAVTESKRDDRQLFLYVHENSDDFNLLFPTKAHCKKAYDDMKSMADVADGNYQGRVLSNPDNEKIRFEYELSNSNERVVLGKGTYGTVYAARDMDTQRQIVVKEIEVKYDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCKRLAGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIYHNHHSISRTRSGSINKKPATKIELNHDKEKKEKSKNQREMLRSTSHIGGMGVVERSPPTPEPMSATLTAGFSHVHSQTVSNALSTAREEKKLHLKIDHARNRTFSSSSPVPDGQSSAGTNMSHPGFQLSQPSSPIVDDTNHPHLIVSPISLNTMGSPLSSAALLNRTISDESSNSSSRFFMLQKDSERRRSLGQFMQDYKDLIIDSWSTLLIKQSDTELVVTVYMLEMLLDGMRDFLLKKDNTKMQKMIDDIRGLLDYDTAKIGQINLALYHFSDSIQPVLRRLDIKPHWMFALSNLITSAVQCAISILSPDLSLLLHAQDNLPSTSSIVAIRNSSLSEGEALIESRPPSREERVREDRKELRTLQEENEILIERLLQVERELNAQLKSGITRANRFRDFAMYRNTYPPFRTPPVAHAPPTPPFSASCGAQPSGTFTNQPPSFASIKPIAQKIIMPPGTENNYQVTRVQEELVSWLRGLEIDERSIALIASEAYTKSDMMDFVTRDELLSIGVGGGSSCRIMRAIGEVRERQRRQPVFLSPMRSRDDSLDDYHSSSADDMYTGAAAETSSGN", "function": "Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. Probably by activating the sek1/pmk-1/skn-1 pathway, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection. Probably downstream of tir-1 and nipi-3, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. Plays a role in resistance to several environmental stresses including oxidative, protein misfolding (ER) and osmotic stresses, and DNA-damaging reagents. Plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress. Involved in germline apoptosis induced by heavy metals, such as Cu(2+). In addition, plays a role in the up-regulation of gcs-1 upon arsenite treatment, most likely through activation of pmk-1, to confer protection against toxicity induced by heavy metals. Plays a role downstream of tir-1 in regulating susceptibility to anoxia. Involved in egg laying.", "AFDB_id": "AF-Q21029-F1-model_v4" }, { "swissprot_id": "Q9VPS5", "sequence": "MFRSCVPKAITSSRCFARMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGTITVKDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLIIIAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELKTESADLQKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKVLNGSEDYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVASLLSTTEVVITDSRNDDLLSKLSGAGGGMDDGLDMNMGGLEELAALSGLGGMGGMGGMGGMGGMGGMGGGFGGMGAGGGMSASASNDGPTAEEMNEMVKAIPGMEQVEVRDIDSGMM", "function": "Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.", "AFDB_id": "AF-Q9VPS5-F1-model_v4" }, { "swissprot_id": "Q52439", "sequence": "MTRVAMAQKTAELIQEFAWPAQPVSPQLQHEVEQFYYREAQLLDHHNYNAWFDLLEQDIHYWMPIRTTRIKRENDKEYIPAGANAHFDENHETMRGRIRQRTSELNWAEDPLSRTRHIVSNVIVRETDTPATLEVASAFLVYRNRLERQVDIFAGERRDVLRRANNGLGFKIARRTILIDQSTILANNLSVFF", "function": "The beta subunit may be responsible for the substrate specificity of the enzyme.", "AFDB_id": "AF-Q52439-F1-model_v4" }, { "swissprot_id": "D4H539", "sequence": "MCNCKKNIKVDESYVSFKDIDCFENACLVIDNLLRILKEPKNTNAYWEKFIEKIPEAYYTRDSKKDPSEALLYLVCSCTSNIMELFEEIDDEEAIDAMSKCEQECC", "function": "Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.", "AFDB_id": "AF-D4H539-F1-model_v4" }, { "swissprot_id": "Q6E7F4", "sequence": "MKILVTGGAGFIGSAVVRHIINNTQDSVINVDKLTYAGNLESLTEIENNERYKFEHADICDSVAIANIFAHHQPDAIMHLAAESHVDRSITGPADFIETNIVGTYILLEEARKYWLALSEDRKGAFRFHHISTDEVYGDLPHPDEVSSDTILPLFTEQTSYSPSSPYSASKASSDHLVRAWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLIILNAIAGKLLPVYGNGEQIRDWLYVEDHARALYEVVTKGVPGETYNIGGHNERKNIDVVKTICRILDELIADKPDGIENFEQLIRYVSDRPGHDLRYAIDASKIKQDLGWVPQETFETGITKTIHWYLNNKEWWQRVMDGSYAGERLGLVE", "function": "Catalyzes the dehydration of dTDP-D-glucose to form dTDP-4-dehydro-6-deoxy-D-glucose via a three-step process involving oxidation, dehydration and reduction. This reaction is a step in the biosynthesis of D-fucofuranose, a component of E.coli O52 O antigen.", "AFDB_id": "AF-Q6E7F4-F1-model_v4" }, { "swissprot_id": "O14302", "sequence": "MSIPKQLPCMVRALYAWPGEREGDLKFTEGDLIECLSIGDGKWWIGRHINTNTQGIFPSNFVHCLDIPTVRPGSSMSRTSASSFRYSSPQKSSIDTPITSSDQGLTPDLVGSSNALNKPTRESDSLKHQKSHPMLNSLGSSLSLKKSVSRPPSSMSRTNLDVSSRWDNTADNDSQIDAQDLSRSTPSPLRSAMENVLQSLNAMGKKSFSRANSPLLRLTKSTTTSKETDFIPVPPAHGSTSMTSRSKLDDSTDNSSKPRTSLQPGESPMKSSRDISRKPSMASSVLSPSDYFPQHRRFQSAPAPIPRPVSTLIPLTQVRTTASNVIKPRPQTTERPSTAQSFRKGGGFLKKTFKKLLRRGSSKRKPSLQPTPPVSYPAHNVPQKGVRPASPHTLKSVKDDLKRTKTYTKAEFAAKREEIFNKLSMPVYEPLKDLSECIGNVLADGEPVQFSVGTNIHNMNFSAIDKQIRSIIPQRVQVSPAVLAKNYLAPGQTTALAQMRAVFIYISERITFTNQTLDNDELRTSTQVISEGQGTPFEVALLVKEMLQALDLWCEVIEGYLKSPDDIYYTRDININHAWNVVTFDNEVRLIDASFASPTHPQQALKSSSSNDFYFLMKPNECIFTHVPENPDQQFIMPDLSMPIVMALPWVSSVYFTLGLKLRKFNTSILHLNDLEVLQIEFLAPKDIECVAEVDALSALAPTADVSQCYKYTLTQAFWETPDIRVMRVKAVMPANNRAAVLRIYAGRLGVSSPVRTAPHPMAMSLPFVHHGKNKALEFVTRHPVPHCPSVDLYINSPQCGTLHSGVEYKFNVSAYACQPSTSISNTRLAIQTPTGNIVRLREERSGNGVIFFSLSLTINETGEYRALILAEKIGRWVVYATWQAV", "function": "Involved in cytokinesis.", "AFDB_id": "AF-O14302-F1-model_v4" }, { "swissprot_id": "Q38796", "sequence": "MDAFKEEIEIGSSVESLMELLDSQKVLFHSQIDQLQDVVVAQCKLTGVNPLAQEMAAGALSIKIGKRPRDLLNPKAVKYLQAVFAIKDAISKRESREISALFGITVAQVREFFVTQKTRVRKQVRLSREKVVMSNTHALQDDGVPENNNATNHVEPVPLNSIHPEACSISWGEGETVALIPPEDIPPDISDSDKYFVENIFSLLRKEETFSGQVKLMEWIMQIQDASVLIWFLSKGGVLILTTWLSQAASEEQTSVLLLILKVLCHLPLHKASPENMSAILQSVNGLRFYRISDISNRAKGLLSRWTKLFAKIQAMKKQNRNSSQIDSQSQLLLKQSIAEIMGDSSNPEDILSLSNGKSENVRRIESSQGPKLLLTSADDSTKKHMLGSNPSYNKERRKVQMVEQPGQKAAGKSPQTVRIGTSGRSRPMSADDIQKAKMRALYMQSKNSKKDPLPSAIGDSKIVAPEKPLALHSAKDSPPIQNNEAKTEDTPVLSTVQPVNGFSTIQPVNGPSAVQPVNGPLAVQPVNGPSALQPVNGPSAVIVPVQADEIKKPSTPPKSISSKVGVMMKMSSQTILKNCKRKQIDWHVPPGMELDELWRVAAGGNSKEADVQRNRNRRERETTYQSLQTIPLNPKEPWDREMDYDDSLTPEIPSQQPPEESLTEPQDSLDERRIAAGAATTSSSLSSPEPDLELLAALLKNPDLVYALTSGKPSNLAGQDMVKLLDVIKTGAPNSSSSSNKQVEERVEVSLPSPTPSTNPGMSGWGQEGIRNPFSRQNQVGTAVARSGTQLRVGSMQWHQTNEQSIPRHAPSAYSNSITLAHTEREQQQYMQPKLHHNLHFQQQQQQPISTTSYAVREPVGQMGTGTSSSWRSQQSQNSYYSHQENEIASASQVTSYQGNSQYMSSNPGYESWSPDNSPSRNQLNMRGQQQQASRKHDSSTHPYWNQNKRWR", "function": "Seems to play a role in the regulation of flowering time in the autonomous flowering pathway by repressing FLOWERING LOCUS C expression.", "AFDB_id": "AF-Q38796-F1-model_v4" }, { "swissprot_id": "Q54BP9", "sequence": "MSNNSNNNIKTYYIIGIITLIFIVSAVIKNQLSSSNQEQQEEEEETDSMGKSKGRGNKKGKKPEKIQEKKLDNHLKNLEKVKLQEDFKLQQDEKQQLKKEETILVEKQEIVVDELKNKKDEEKQQQQQEEDQQQQQQQQQEEEEEEEEQQEIEEDEEEEEGQEQEEEEEQQEIEEGEEEQQEEEQEEEQFSMFGVSIERLMDFQRQEDENEGSDEVEESSKVPIVLSFMLDRIKNLNGFKTEGLFRVNGNLKLVEQLATEGFDPFSDDLDPNVNTWASLLKKWIRDLPEPLIPHELNPIILDFCTNNNINNTCNNNNDNNNNNNFNVCASTNNLGNVLNLSTNICNNNNNNNNNNNNNNNNNNNNDNNNNNNESIEKKITNIINMIKSDDHRNVLYKIGEFFGEMLQEETVLITKINVESLSKILTPSLFKPNNIIDDFSNGSLNGSGNQIPKYLTTLDLPSILLKQKKEIAFVSCLLNYFKDEYSKKLQEQNDQEEDNQEEEKDNQEEDEDEEDKDQEE", "function": "Rho GTPase-activating protein involved in the signal transduction pathway.", "AFDB_id": "AF-Q54BP9-F1-model_v4" }, { "swissprot_id": "P0CW32", "sequence": "MLSDEEREAFRQQAAAQQMSLSNWLRQAGLRQLEAQRQRPLRTAQELREFFASRPDETGAEPDWQAHLQVMAESRRRGLPAP", "function": "Putative antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC23.", "AFDB_id": "AF-P0CW32-F1-model_v4" }, { "swissprot_id": "Q17678", "sequence": "MTFYILVVSLYLSLFLVTVVQSDCDTDVEQRERNIFLWSVKHPQFASSQGYLFGTIHVPFTEVWKEVSDRVRDAFAVSDTVLLEIDLHDEATIHELIACKNLAYDETVHSYLSIELLERIEKIMEYLRSSFLAWAQKQNPRDTKKIKHAEDIYNNIIGDWWRKRPIWLLFLLYQMCENVFEKSSSPLLDLYIAQRATDEKKTIIPIETAEEQCNPVVSVSTNEIIFAIEHTVHYFEDKILDNPSKDNESRSSLKELVEHYKCGTLKEDMFDKDGMSIIDYATGTTERFKADEINKKLKQDIFVKRNLRMAKRIEKILKGRNSNTVFSAIGAGHFFGSSSVLTYLEESGFIVQKLKNTDVIQPLRSPYRQTAKFKRVWTKETAVRRKSIIIEEVAPSSSRIARLWLVPCIFLLHSIFAIFP", "function": "Metalloprotease.", "AFDB_id": "AF-Q17678-F1-model_v4" }, { "swissprot_id": "P34631", "sequence": "MQWFGGNVATAIQISRKNKALLIVYITTDSEDGQIFDGFWQHIDSSNLLCAVVGIKLKAGETSAQQFADIYPTPILPAAYLIDQNGKPLEVITPLVGKTYDQFRAKFDKATAQFVNGMPTAAANQLSTPSPSPAPVQVPASTDAPIPAPTPVTAPIQSSSTSQEMTRELAEKVARAKALLEQKKQKDAEKKREADKHVKEEMTKAREAKQERDAEALVKAAKQRKMEKLAAESDKKRILAQIKADREAAQKKFGKLVNTENASENTEKKQETTVGKAVPSDRCRLQVRLPDGSTFVEEFPSNDVLNSLVEIIRQKPSIAGTTFEIQQPYPRRIFTNDDYSKTFLENQLTPSTALVVIQKSSGSSSNYGSFSLSTQTVSFVTWVLYPLTAFWNIFCGMIGWNSTGKQQDSKSKKNDGPSTSGQSGSQPQRRGMPRSAEVRRRGNVAGLENPNEDDPEERASFNGNSTQFM", "function": "Probably acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. May play a role in the ER-associated protein degradation pathway (ERAD) possibly acting as a platform to recruit both ubql-1 and cdc-48.1 and/or cdc-48.2 to the ER during ERAD.", "AFDB_id": "AF-P34631-F1-model_v4" }, { "swissprot_id": "P34719", "sequence": "MKLAFDDFLNSMSETNTTLDYFTDFDKVKKNVAQIEIHLNQLNYLLGKDDLKQAVYDLYAECPNAFSILEILIAVRKKEQKKSLDEKGQVVTLNSYFQSADKIIDFLNNTGLADVFRDKNIKNLVDYVFGIEVGLDTNARKNRGGDNMSKAVQLLFDNADIYYKKEVRNTIFTDIESLGADVKQFDFVIKTKRKTYVIETNYYNSGGSKLNEVARAYTDVAPKINQYSQYEFVWITDGQGWKTAKNKLQEAYTHIPSVYNLYTLHGFIEQLNSEGVIKDW", "function": "A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3' and cleaves before G-1.", "AFDB_id": "AF-P34719-F1-model_v4" }, { "swissprot_id": "Q7S133", "sequence": "MTTMMTDSGTASDSGAGLVDSTRNDTTTTTTTTTTPGDNDADDDNTNGTTTGHHDNNETDNNSKSYSSTHHVPAIDNTSTTNANDNEDAAGFLDRDQSPLSSISSPLSEPDNFEFDTEPIPSILSPKSTTSDNHARDGETPELDEDGQPPAKRRRVRETTPHNHSRKPKPESPPWKKFEAEGPTTIITEDGRRKSGRVNPVLLGMKPSDKKVTRKAIQTSPVSNKSSASTSRKPAPASSSNSKHAPAKMPPPPPPPKAPARKSATTHETRPSASRSRRRSPSPRRPATPPKPAAVGTRRSTRQALAHSRASYDDGQLSPGASRATPRIKLKVRPPLTVIPLVHPNQANVRPKLGPTFEEYFARAHEIPVEEGGQHIPDEEPKYTDEMALQDAKVILRVEKEVEPGGLLAPDRCSAFEPEAEEEPPRQWAHLDHLTKAMTNFRKLMYREQQLHMQAAKRIAIACEAEWRRRNPQPKTAEEIELEEMEASKAKWRQVIRAFAGTWENVRVEVNRRRLVEWEAEEQRRVKAALNQAVNLSEQKLQQRQAQVDGDEITDEDEDEDDEDLASGMPSVMGDEKESDEHSDQGSDEMSDENDEDEDEDNMSSSEDDDKKSTASDEGLTQEELRAKYANLPTLGTTDETEETTKDVEMADAPAAMDGSVANDDDTSDESVDMDDDLGSSEESDDDEEEEEDDEEEEESDDEPAGLLGLFFGKSELKKLKEEAVTEEPSVEPAGDVEMTDASAALRPELQVNGHAHEAPITNGTHTNEQLASSQTEGADDEVSLLVIPNDEIAAENTQTAAEPGSGVVEKDFLTNDSSLKYPNEIVQSENQTLPAKESVEAGGDLPMVDAPSTDDLQRETAAAPSLEAPPNTRHDSQETVAATDMQSQSQTQSPKTTDTKPTDVDTPHSELAVSVQKPDSRQSSPQPTTPTVKTEIPFLLRGTLREYQHHGLDWLAGLYANNTNGILADEMGLGKTIQTIALLAHLACHHEVWGPHLVIVPTSVMLNWEMEFKKWCPGFKILTYYGNQEERKRKRQGWNNDDVWNVCITSYQMVLQDQQVFRRRRWHYMILDEAHNIKNFKSQRWQTLLGFNTQARLLLTGTPLQNNLTELWSLLYFLAPPENGEGGFVDLTEFHNWFARPESQILESGREQLDDEARAIIAKLHKVLRPYLLRRLKADVEKQMPAKYEHVEFCRLSKRQRELYDGFLSRADTRETLQSGNYMSIINCLMQLRKVCNHPDLFVDRPIMTSFRMSRSVPADYEWKEKFIRNRLLATKPMTTVNLSFLNMIPTEYEDLSKTHTDRIAQLSSHRILLDLREAQKVRANNAYTALDPSSVKSNLVYLESAARWGRFEELQHCVYINALRRQQRPIYGKRLTEFLTLDTHLRPYKPRPRVPAKIMSWFEEDSFLLHNAIPTLQQRAESMEMTITKFACVTPAVVTGPEMNRFLLGERGIQLFEDLDLKLSAPVKYAPYMPPQPPPDPWHEARMRLTIQFPDKRLLQYDCGKLQALDKLLRKLQAGGHRALIFTQMTKVLDILEQFLNIHGHKYLRLDGATKVEQRQILTDRFNHDPRILCFILSTRSGGLGINLTGADTVIFYDQDWNPAMDKQCQDRCHRIGQTRDVHIYRLVSEHTIEANILRKASQKQMLDDVVIQEGEFTTDYFNRLSVRDVLGSNGEVIASNEDDVAANLAMDRVLGGPSTTGAGGYDGTADGGGGASQPPVRNVGRVLEMAEDREDVDAAKAAEKEIMQDEADFGEAGSTRPGTPGDGLADLDGQLLGGEENKEVEDEVIEYNAWGERMHTIDEYMLGFMAKALEGTPLELPRDRKKGRDRNRNRKGKDSRKR", "function": "Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.", "AFDB_id": "AF-Q7S133-F1-model_v4" }, { "swissprot_id": "Q6FP25", "sequence": "MSKRRKNQGYLAIIAAVSIGAAAYLWWRNHSEDDSVSKFNQQDDGTAQDNQIKEKPAIKLGKKRLHRSLCVIISNKLSNLVELDWDEILQEDIVFLILPSVNDFQNSNDIKTDTHKIINCDTELGLWACVRTLKKNELLVCADDIKVPDDIGRYCDKISQIKSSQQLMNYLDET", "function": "Involved in peroxisome biogenesis.", "AFDB_id": "AF-Q6FP25-F1-model_v4" }, { "swissprot_id": "Q9C6M5", "sequence": "MEYSCVDDSSTTSESLSISTTPKPTTTTEKKLSSPPATSMRLYRMGSGGSSVVLDSENGVETESRKLPSSKYKGVVPQPNGRWGAQIYEKHQRVWLGTFNEEEEAASSYDIAVRRFRGRDAVTNFKSQVDGNDAESAFLDAHSKAEIVDMLRKHTYADEFEQSRRKFVNGDGKRSGLETATYGNDAVLRAREVLFEKTVTPSDVGKLNRLVIPKQHAEKHFPLPAMTTAMGMNPSPTKGVLINLEDRTGKVWRFRYSYWNSSQSYVLTKGWSRFVKEKNLRAGDVVCFERSTGPDRQLYIHWKVRSSPVQTVVRLFGVNIFNVSNEKPNDVAVECVGKKRSREDDLFSLGCSKKQAIINIL", "function": "Transcriptional repressor of flowering time on long day plants. Acts directly on FT expression by binding 5'-CAACA-3' and 5'-CACCTG-3 sequences. Functionally redundant with TEM2.", "AFDB_id": "AF-Q9C6M5-F1-model_v4" }, { "swissprot_id": "Q81YT8", "sequence": "MKSSNKLMALGIVFSIAVLIVIGTIVYSIINDKKDKGNEMFAYSTQQSLGKDDAPVKVVEFGDFKCPACRTWDVTVLPRLKEEYIDKGKVQLYFINFPFIGKDSDLGAAAGEAIYKQDQDSFWIFYDEIYQSQKKDTEEWITEELLLNIVKEKLPKIDVEQFKKDLHSKEIKEKVRKDSDRAQKLKVQGAPSVYVNGNLANPDFDSLKKAIDKELKK", "function": "May be required for disulfide bond formation in some proteins.", "AFDB_id": "AF-Q81YT8-F1-model_v4" }, { "swissprot_id": "Q2TBP8", "sequence": "MATGRGSRYLLTIGRWRRSFGIAPQFRALAALVPGVSHVDNKSDFLGKRPHRRHPGILQLSCVRLPQALAEAGQLLLLGSAMPNMEKQVQALTNYLWSRHLPVEPEELQRRAVLLEKKILENADSCQTEKHHEEILHALRRTTYHWQELSYSEGLSLVYMAARLDGGFAAVSRAFHEIQARLPEFQPQTLMDFGSGTGSVTWAAHSTWGQSLREYMCVDSSAAMLELAEKLLKGGSGSGMPCVPGVFFRQFLPVSPKVQFDVVVAAFSLSELPSKADRTDVVQTLWRKTGHFLVLIENGTKAGHSLLMDARDLVLNGKEKSPLDPRPGFVFAPCPHELPCPQLTASKPLACSFSQAYYPIPFSWNKKPKEEKFSLVILARGSPEKANRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVITARRHGRDLYRCARVSSWGDLLPVITPLELPPSAQDAQDAPES", "function": "Probable S-adenosyl-L-methionine-dependent RNA methyltransferase required to stabilize the mitochondrial small ribosomal subunit (mt-SSU). Required for protein translation in mitochondria.", "AFDB_id": "AF-Q2TBP8-F1-model_v4" }, { "swissprot_id": "Q8EAX8", "sequence": "MHESQLTTSAAKPSRLGWFDDVLLLGIMAVLAGCGLIYEYLLSHYAGRILGALEAAIYTMIGLMIVSMGLGAFAARKIKDAFTGFVVLELTVALCGSLAILITAAVIGFGQQLPMLIASTLGLPPDQLPEGGMIGTLQKLSEYLPYFWGVLLGLMIGMEIPLIARVRQSLSDEHLLHNAGTIYGADYIGAGIGAAIWVGFMLAIDIQLAAALTASFNLLAGFVFIWRFWQKIQRPKLLLAAHLVVTGVLLLLAIQGPSWEQQFNNLLYKDKVVYAKATRFQQLTFTERLRGNGLSPVYALYINGRLQFSSSDEHIYHAFLVHPTLAASARHNKVLIIGGGDGLGLKQVLRWEPEQVTLLDLDAALVQLFKSPDPDMPERLSQALLSLNGNAFNDPRVTVIHDDAFNGVDKLIAKGDKYDAIIVDLPDPSHPDLNKLYSDYFYRKLKELISNDGALTVQSTSPYHAQKAFISVAKTLALAGFDVKQYHHNVPSFGEWGWSIATLDGKDAQHRLAQLTKLPIADDWLTLGLVKGAFEFPANFYQDATNIKPNELGSLQLYHYHQQAWSETQGLDLF", "function": "Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.", "AFDB_id": "AF-Q8EAX8-F1-model_v4" }, { "swissprot_id": "Q84WW6", "sequence": "MQFSCDPDQEGDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLNVITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKCEGRGWGLVALEEIKAGQFIMEYCGEVISWKEAKKRAQTYETHGVKDAYIISLNASEAIDATKKGSLARFINHSCRPNCETRKWNVLGEVRVGIFAKESISPRTELAYDYNFEWYGGAKVRCLCGAVACSGFLGAKSRGFQEDTYVWEDGDDRYSVDKIPVYDSAEDELTSEPSKNGESNTNEEKEKDISTENHLESTALNIQQQSDSTPTPMEEDVVTETVKTETSEDMKLLSQNSQEDSSPKTAIVSRVHGNISKIKSESLPKKRGRPFSGGKTKNVAQKHVDIANVVQLLATKEAQDEVLKYEEVKKEAAVRLSSLYDEIRPAIEEHERDSQDSVATSVAEKWIQASCNKLKAEFDLYSSVIKNIASTPIKPQDTKTKVAEAGNEDHIKLLEAK", "function": "Histone methyltransferase involved in regulation of flowering time. Required for the expression of the SOC1/AGL20 gene. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the SOC1 locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus.", "AFDB_id": "AF-Q84WW6-F1-model_v4" }, { "swissprot_id": "Q8W234", "sequence": "MVPSEPPNPVGGGENVPPSILGGQGGAPLPSQPAFPSLVSPRTQFGNNMSMSMLGNAPNISSLLNNQSFVNGIPGSMISMDTSGAESDPMSNVGFSGLSSFNASSMVSPRSSGQVQGQQFSNVSANQLLAEQQRNKKMETQSFQHGQQQSMQQQFSTVRGGGLAGVGPVKMEPGQVSNDQQHGQVQQQQQKMLRNLGSVKLEPQQIQAMRNLAQVKMEPQHSEQSLFLQQQQRQQQQQQQQQFLQMPGQSPQAQMNIFQQQRLMQLQQQQLLKSMPQQRPQLPQQFQQQNLPLRPPLKPVYEPGMGAQRLTQYMYRQQHRPEDNNIEFWRKFVAEYFAPNAKKRWCVSMYGSGRQTTGVFPQDVWHCEICNRKPGRGFEATAEVLPRLFKIKYESGTLEELLYVDMPRESQNSSGQIVLEYAKATQESVFEHLRVVRDGQLRIVFSPDLKIFSWEFCARRHEELIPRRLLIPQVSQLGSAAQKYQQAAQNATTDSALPELQNNCNMFVASARQLAKALEVPLVNDLGYTKRYVRCLQISEVVNSMKDLIDYSRETRTGPIESLAKFPRRTGPSSALPGPSPQQASDQLRQQQQQQQQQQQQQQQQQQQQQQQQTVSQNTNSDQSSRQVALMQGNPSNGVNYAFNAASASTSTSSIAGLIHQNSMKGRHQNAAYNPPNSPYGGNSVQMQSPSSSGTMVPSSSQQQHNLPTFQSPTSSSNNNNPSQNGIPSVNHMGSTNSPAMQQAGEVDGNESSSVQKILNEILMNNQAHNNSSGGSMVGHGSFGNDGKGQANVNSSGVLLMNGQVNNNNNTNIGGAGGFGGGIGQSMAANGINNINGNNSLMNGRVGMMVRDPNGQQDLGNQLLGAVNGFNNFDWNA", "function": "DNA-binding adapter subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and LEUNIG to repress AGAMOUS expression. In association with LUG, regulates petal shape through AGAMOUS-independent mechanisms. Controls cell division during petal development and enable the proper patterning of petal blade vasculature. Required for the proper elaboration of petal polarity along the adaxial/abaxial axis. May act through direct or indirect regulation of PHABULOSA and YAB1 and thus regulate cellular proliferation within the developing petal blade. In association with AINTEGUMENTA (ANT), coordinates patterning cues and cellular proliferation along the three positional axes of the developing gynoecium. Required for the development of the medial ridge and subsequent ovule initiation.", "AFDB_id": "AF-Q8W234-F1-model_v4" }, { "swissprot_id": "Q9ZGH1", "sequence": "MTAPALSATAPAERCAHPGADLGAAVHAVGQTLAAGGLVPPDEAGTTARHLVRLAVRYGNSPFTPLEEARHDLGVDRDAFRRLLALFGQVPELRTAVETGPAGAYWKNTLLPLEQRGVFDAALARKPVFPYSVGLYPGPTCMFRCHFCVRVTGARYDPSALDAGNAMFRSVIDEIPAGNPSAMYFSGGLEPLTNPGLGSLAAHATDHGLRPTVYTNSFALTERTLERQPGLWGLHAIRTSLYGLNDEEYEQTTGKKAAFRRVRENLRRFQQLRAERESPINLGFAYIVLPGRASRLLDLVDFIADLNDAGQGRTIDFVNIREDYSGRDDGKLPQEERAELQEALNAFEERVRERTPGLHIDYGYALNSLRTGADAELLRIKPATMRPTAHPQVAVQVDLLGDVYLYREAGFPDLDGATRYIAGRVTPDTSLTEVVRDFVERGGEVAAVDGDEYFMDGFDQVVTARLNQLERDAADGWEEARGFLR", "function": "Involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics. Catalyzes the SAM-dependent deamination of dTDP-4-amino-4,6-deoxyglucose (dTDP-viosamine) to yield dTDP-3-keto-4,6-deoxyglucose. It can also catalyze the oxidative dehydrogenation of the non-physiological substrate dTDP-D-quinovose to dTDP-3-keto-6-deoxy-d-glucose. It can also deaminate dTDP-3-amino-3,6-deoxyglucose.", "AFDB_id": "AF-Q9ZGH1-F1-model_v4" }, { "swissprot_id": "Q9CEP1", "sequence": "MKYEDINENTIKITLSFDDLTDYDIKLSDFFGNQEVIEQFFYELVDELGLENRFGNVGMLTFQIQPFPQGVHMIVHEEAMLGEGGEIPDDPEEFEELMTGFYNKLNEIGADMARERGITDFKPGLGLPGTKKDEAEQEPDFIYYSIRYEDIMSVLTGIKNVKFADEESEFYRYDGNFYLVVLDNQKEKGKMHVESTRSRMMEYGEATKMSREFLQEYGECLIATRALDVLRKI", "function": "Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.", "AFDB_id": "AF-Q9CEP1-F1-model_v4" }, { "swissprot_id": "Q5JBG6", "sequence": "MVINIFYICTGEYKRFFDKFYLSCEDKFIPEFGKKYYVFTDSDRIYFSKYLNVEVINVEKNCWPLNTLLRFSYFLKVIDKLQTNSYTFFFNANAVIVKEIPFSTFMESDLIGVIHPGYKNRISILYPWERRKNATCYLGYLKKGIYYQGCFNGGKTASFKRLIQICNMMTMADLKKNLIAKVHDESYLNYYYYYNKPLLLSELYSWPEKYGENKDAKIIMRDKERESWYGNIKK", "function": "Involved in the assembly of the O-repeating unit during O-antigen biosynthesis.", "AFDB_id": "AF-Q5JBG6-F1-model_v4" }, { "swissprot_id": "A0A1B4XBI3", "sequence": "MELLSLGSRQRPSLHEIGLSIISLTTCFVCAFAVSFVALAIYRAHLHPLAAIPGPKLAALSSAWQAYHARNGRMLVLGKTLHAVYGPIVRVGPNEVWLNSPDAFRSIYGAGNGYEKSDFYLSTVLNKPAIDWGLNLHFPDTLDLLSEFDTRRYRLQRRLVGPVYQANNIKKFQNAVDDVIERAVAQLRTLDGAEVDLKEWMHIIVVECLGAVVLSWSPGYIAAETDGGTGTQSYLGWKRKSVFGLFPLVTTATFFSKGLGRLFSNLWGVTFPTPKNFKPFFTPVYHKSSKRINVALRQNAGSNTRPKPPKRKQDTQPNDLLTDLIQLHKAKAEFTEQYLRRMAITNFGAGHETMCSALTSIMAMVGSHPAVQGRIIDELGSHGYLPSTCTSKDQKPIAGQTHIDYDAAASLTYCLAAIKEAQRLYPVIGMSLSRKVPASGLSVHDVYIPPGTTVGCSPVSLHRNTTIFGDDASCFNPERWLQDNVEARRAMERYNLTWGGGGRTCPGRHLAEMVVWKVVPALLREFEVVVTKMPNDVEVEYYFMAMLTGVRARFIPRR", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sordarin and hypoxysordarin, glycoside antibiotics with a unique tetracyclic diterpene aglycone structure. First, the geranylgeranyl diphosphate synthase sdnC constructs GGDP from farnesyl diphosphate and isopentenyl diphosphate. The diterpene cyclase sdnA then catalyzes the cyclization of GGDP to afford cycloaraneosene. Cycloaraneosene is then hydroxylated four times by the putative cytochrome P450 monooxygenases sdnB, sdnE, sdnF and sdnH to give a hydroxylated cycloaraneosene derivative such as cycloaraneosene-8,9,13,19-tetraol. Although the order of the hydroxylations is unclear, at least C8, C9 and C13 of the cycloaraneosene skeleton are hydroxylated before the sordaricin formation. Dehydration of the 13-hydroxy group of the hydroxylated cycloaraneosene derivative might be catalyzed by an unassigned hypothetical protein such as sdnG and sdnP to construct the cyclopentadiene moiety. The FAD-dependent oxidoreductase sdnN is proposed to catalyze the oxidation at C9 of the hydroxylated cycloaraneosene derivative and also catalyze the Baeyer-Villiger oxidation to give the lactone intermediate. The presumed lactone intermediate would be hydrolyzed to give an acrolein moiety and a carboxylate moiety. Then, [4+2]cycloaddition would occur between the acrolein moiety and the cyclopentadiene moiety to give sordaricin. SdnN might also be involved in the [4+2]cycloaddition after the hypothesized oxidation to accommodate the oxidized product and prompt the [4+2]cycloaddition. GDP-6-deoxy-D-altrose may be biosynthesized from GDP-D-mannose by the putative GDP-mannose-4,6-dehydratase sdnI and the short-chain dehydrogenase sdnK. The glycosyltransferase sdnJ catalyzes the attachment of 6-deoxy-D-altrose onto the 19-hydroxy group of sordaricin to give 4'-O-demethylsordarin. The methyltransferase sdnD would complete the biosynthesis of sordarin. Sordarin can be further modified into hypoxysordarin. The unique acyl chain at the 3'-hydroxy group of hypoxysordarin would be constructed by an iterative type I PKS sdnO and the trans-acting polyketide methyltransferase sdnL. SdnL would be responsible for the introduction of an alpha-methyl group of the polyketide chain. Alternatively, the beta-lactamase-like protein sdnR might be responsible for the cleavage and transfer of the polyketide chain from the PKS sdnO to sordarin. Two putative cytochrome P450 monooxygenases, sdnQ and sdnT, might catalyze the epoxidations of the polyketide chain to complete the biosynthesis of hypoxysordarin. Transcriptional regulators sdnM and sdnS are presumably encoded for the transcriptional regulation of the expression of the sdn gene cluster.", "AFDB_id": "AF-A0A1B4XBI3-F1-model_v4" }, { "swissprot_id": "P83342", "sequence": "AELERLSEDDATAQALSYTHDASGVTHDSYQEGSRCSNCLLYSNPDAKDWGPCSVFPKHLVAEGGWCTAWVGRG", "function": "Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.", "AFDB_id": "AF-P83342-F1-model_v4" }, { "swissprot_id": "Q9ZMV2", "sequence": "MSRNEVLLNGDINFKEVRCVGDNGEVYGIISSKEALKIAQNLGLDLVLISASAKPPVCKVMDYNKFRYQNEKKIKEAKKKQKQIEIKEIKLSTQIAQNDINYKVKHAREFIESNKHVKFKVVLKGRESQNSKAGLDVLFRVQTMMQDLANPEKEPKTEGRFVSWMFVPKAKEAPKNEKKTKENNPPFNRINLMKGENHAKNED", "function": "IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.", "AFDB_id": "AF-Q9ZMV2-F1-model_v4" }, { "swissprot_id": "C3YEM5", "sequence": "MPCPTGVTRCSAGVSSLARCLHTCPVLEGVTKANLSKLRKKTGFTFVNCRKALEKFENDLEQAEKWLKEQAQKEGWAKATKLQDRQTAQGLVGVAQEGTMATMVEVNCETDFVARNPKFRQLVTQVAMATLGDVKAHPQWTLGWLKALHTGEELKQLQIGDTTLGDLTALTIGTLGENIQIRRAMYYSVPPIPTKHVGVYVHAPVAGTTGGQSGSCALGKYGALVAFRRKNTEFQNFNAAELGRRLGQHVVGMSPLTVGEMPEVREEEGEKKDGDKQDEEERSTDSDEDETQMLRQTFLLDPTMTVGEMTRQQGIELLDFVRFECGEVEES", "function": "Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.", "AFDB_id": "AF-C3YEM5-F1-model_v4" }, { "swissprot_id": "Q01607", "sequence": "MSGGRWISNLRQVFGRSRASISSSLLPFPPTSISSGFHVPRLLDAWKNPVAAAAAFRLPQSSGFATMNQLIRHGREEKHRSDRKRALGKCPQKQGVCLRVSTRTPKKPNSALGKIAKVRLSNRNDVFAYIPGEGHNLQEHSMVLVRGGRVKDLPGVKFHCIRGVKDLLGIPDRRRGRSKYGAEKPKST", "function": "Protein S12 is involved in the translation initiation step.", "AFDB_id": "AF-Q01607-F1-model_v4" }, { "swissprot_id": "Q6BTC8", "sequence": "MENIAHHNTTYNITPICSDSSECSSMEMLPLGCKTHSDKSDARRNLMDTGIYTPDSNSDSSDPRSDSSCVDVSNSLAVSHPISFCNWTDEESSLLTEHIKTDLTSEALTSAFPNKSLALIIRKIHDLQPVLDWTKNEIYLLAGIILNDSNSAIRRHKHKFPCRNVSNLNKKFQHYKNMVRRLNGVDHSKWTKPEIASLISLIDYDLTKTKLQKELPNKNIEEIKDLTNEMRIHSNFSHVESVLFEQTMTENDPIEIVLDQFPLKNKETCKKRLLKLNELSQHRDMAKRRLDEFESLIQNELKQIKDSIDLTRLKYLLVNDLTGKQLRSSFPGISMKYLKLIAKEMGFDEAGEYTLAEMNFLKKALQENAKLKSIIDELPFRSQLSIETKINSVEPNRRRSVFTSQVDELLYMAKWYSSDNFGNLSRRRNSRYASKLDKPKDKASDIMQPSKLHLENEEVTEAKVIPHDKGVENMISDHKLKGKNNEQKKRKSKKPTSMVEVLKEESAYFQSVTGNRCVLKEGQKRKRERLMQIKLETKLKKPKSQNLNETNRIQETKKLMKCDVEPDKVKEQKSFKSENLKEAKLDASDSSIVSDVEISLKKKLNKIENEEKRSPYDPEDISTDTLVPLYGRQLYVNEVYETQPRPPKLSFREDTNIMVQNCSEISLTDTIAADIISQHCKNYRDMPISFPSLTIVDRNTNRMILNPMNKIRIRFLLYPQHSELFILAEPKSNELDPINEIKKLFQLHYSLFFSHSSKLKKIILSEYNKEIDISIEENDFVRFMFVIDKWNRLMVELTPNDVDIGSHDINEEIRAYLSPNEIKIPSDEDIRLDIFYSEIQLSTEENPISDNDPIEPSSPSFDLIKSMKRCFTHDSSNRLTPPISSEEDNKENEPPIESDFRNNNNKGSIPCTPVRLNTRNKMVVNAVKPENYESNFFRHLKEKTSVSRFCVQQILLRIYSRIVSTESRKLRSYKAFTAEVYGELLPSFTSEVLTKVNLQPQHKFYDLGSGVGNTTFQAALEFGVHLSGGCEIMEHASKLTELQTMLLNKHLALLGLKKLPLNFALSQSFVENDIVRQAVIECDVLLVNNYLFDVNLNTAVGKMLYGLKPGTKIISLRNFIRPRYKASSDKTIFDYLKVERHEMSNYLSVSWTANKVPYYISTVQENICEEYV", "function": "Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.", "AFDB_id": "AF-Q6BTC8-F1-model_v4" }, { "swissprot_id": "A0PJS5", "sequence": "METEYSKRVYQGVRVKHTVKDLLAEKRLRQTNTPRFSTSSSSSQPAFVPMPGSHVLPGYYSMRRSFLQDSELCHTVKQYSSDTYSSALGSKAFSYDHASTYPAFIDSYYTPDSYGDYRGPTSYTTSGGSLFPPSSLPTLLPTLSGESSSHLLLRDPWDQPSEDSVNQTEVLCPEAAAPVADSPSLAGPDSGSSSPYRLTSGRSGSSIPSSSQPYTLQPLEDVPYTAPSYTSASSYSCPPYMSTPGDLAVVKMTAVTSEEASGGVVSLSDTTSWAKDDGTGSWLSYETRRAF", "function": "Transcriptional coactivator that may regulate cell type-specific differentiation pathways.", "AFDB_id": "AF-A0PJS5-F1-model_v4" }, { "swissprot_id": "Q3TC93", "sequence": "MQSPAVLRTSRQVQNAHTGLDLSVPQHQEVRGKMMSGHVEYQILVVTRLAVFKSAKHRPEDVVQFLVSKKYSEIEEFYQKLYSCYPAASLPPLPRKVLFVGESDIRERRAMFDEILRCVSKDAQLAGSPELLEFLGTRAPGATGLATRDPSVLDDTASQPGDSDEAFDFFEQQDEVQPPTLGLSSKDVEKSLVGEEEEEEEEEEVLDPLGIMRSKKPKKRPEVAVRPKPAPRLTIFDEEVDPDAGLFSSDKKVSETRRPLETTQDSLKLFDDPDLGGAVSLGDPLLLPAASESRGPTSRPEHGDASKELFRVEEDLDLILNLGSEPKPKPQTKPKPLVPAKPALPRKPTLPASVGPSEPGSGPQKQQQIQAMDEMDILQYIRDHDTLAQDSPSLF", "function": "May be a modulator of IL-2 signaling.", "AFDB_id": "AF-Q3TC93-F1-model_v4" }, { "swissprot_id": "Q6CRM3", "sequence": "MGNGNASIEFVSENGPIDFSVMMQEGVKALTKILSTHLQDNPDLINEKSMKVIFKDNNGKLEPVFAPSEGNSGLINGNDQDENYDEDRDIEEANEDYEVIEFDNEGNYHVCAKGTQNRAIGYDEKVYSKSEHYADSTDTHDYDEDGIINEDNNQLLPKDKWNGHMTRLKNGAISSAEHEVVFEHDNGDNTTFSPAETINDGHMDKRDRSHMHHSGHSEKTGGSCACQENKDSFKYPDHVPNSAPNFRALLQHTVNGKQMCPFCEYYVVFGTPPAYIMRWASSKISAEHSQYKMNDQIVDGDSGDMDRNLDSVETNEMNKQQTKKKKKKSKRKSKR", "function": "Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis.", "AFDB_id": "AF-Q6CRM3-F1-model_v4" }, { "swissprot_id": "G2TRJ9", "sequence": "MNQGNQAFENARKPFRRANLITALGLGAFAFATFAYSVYRVHEDTFEDVVMTPELEKKIAEDRDLSKKN", "function": "Required for assembly of cytochrome c oxidase (complex IV).", "AFDB_id": "AF-G2TRJ9-F1-model_v4" }, { "swissprot_id": "Q9UP83", "sequence": "MGWVGGRRRDSASPPGRSRSAADDINPAPANMEGGGGSVAVAGLGARGSGAAAATVRELLQDGCYSDFLNEDFDVKTYTSQSIHQAVIAEQLAKLAQGISQLDRELHLQVVARHEDLLAQATGIESLEGVLQMMQTRIGALQGAVDRIKAKIVEPYNKIVARTAQLARLQVACDLLRRIIRILNLSKRLQGQLQGGSREITKAAQSLNELDYLSQGIDLSGIEVIENDLLFIARARLEVENQAKRLLEQGLETQNPTQVGTALQVFYNLGTLKDTITSVVDGYCATLEENINSALDIKVLTQPSQSAVRGGPGRSTMPTPGNTAALRASFWTNMEKLMDHIYAVCGQVQHLQKVLAKKRDPVSHICFIEEIVKDGQPEIFYTFWNSVTQALSSQFHMATNSSMFLKQAFEGEYPKLLRLYNDLWKRLQQYSQHIQGNFNASGTTDLYVDLQHMEDDAQDIFIPKKPDYDPEKALKDSLQPYEAAYLSKSLSRLFDPINLVFPPGGRNPPSSDELDGIIKTIASELNVAAVDTNLTLAVSKNVAKTIQLYSVKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNSLYKLHQSVTKAIHALMENAVQPLLTSVGDAIEAIIITMHQEDFSGSLSSSGKPDVPCSLYMKELQGFIARVMSDYFKHFECLDFVFDNTEAIAQRAVELFIRHASLIRPLGEGGKMRLAADFAQMELAVGPFCRRVSDLGKSYRMLRSFRPLLFQASEHVASSPALGDVIPFSIIIQFLFTRAPAELKSPFQRAEWSHTRFSQWLDDHPSEKDRLLLIRGALEAYVQSVRSREGKEFAPVYPIMVQLLQKAMSALQ", "function": "Required for normal Golgi function.", "AFDB_id": "AF-Q9UP83-F1-model_v4" }, { "swissprot_id": "P26305", "sequence": "MMNTRALLPLSVLLMATLCLCELPIPILQRFVRSVPEECPIADPSDFKFSITSNRNKTGHWTAQVRLEHGEHEQSGSNQHNRDLWQVDLEQTTTTCAGVKSVQIITTITAPPPTAAPSIPPGYELSAVLGYYKFHKTPKTWDEARIICQQEGGHLVIINSEDESKVLQNLFSKVTKTEGATNNDYIFIGIHDRFVEGEFITIFGKPLATTGFTRWVDSIQPDNAGGNENCGSMHPNGGLNDIPCPWKLPFVCEVEL", "function": "Participates probably in the elimination of foreign substances invading the insect abdominal cavity, and in trapping intracellular symbionts, when they leak from the mycetomes into the hemolymph.", "AFDB_id": "AF-P26305-F1-model_v4" }, { "swissprot_id": "P72296", "sequence": "MPFDPLFLWETFIALLAGIPLALKLAVFSIAVGTVLAFSLALMRVSRRWWLDFPARFYIFAFRGTPLLVQIYIIYYGLSQFPGLRHSLLWPFLREAYWCALGALALNTAAYSAEIMRGGLLSVPAGQIEAARACGMARVLLFRRIIIPQAIRQMLPGYSNEVVLMVKSTSLASTITLMEITGIAAKLISETYRPVEVFACAGAIYLTMNFIAARLFALIEWSLWPERRKTRRPVDLADQKGELHV", "function": "Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.", "AFDB_id": "AF-P72296-F1-model_v4" }, { "swissprot_id": "A1XGB4", "sequence": "MTPPPTSTVPPYVSLIVRILTLICLLISFIVIATNNQTVSTVAGDVKIKFKDFYAYRYLIATVIIGMAYTLLQIAFSISLLTTGNRIGGEGFLLFDFYGDKFISYFLVTGAAASFGMTQDLKQLEGSDNYSKFLNTSNAAASLCLIGFFFAVASSIFSSYNLPKRI", "function": "Required for defense response to Xanthomonas campestris pv. vesicatoria (Xcv). In heterologous systems, confers resistance to bacterial pathogens such as Pseudomonas syringae pv. tomato but susceptibility to pathogenic oomycetes such as Hylaloperonospora parasitica when expressed in Arabidopsis thaliana. May be involved in the regulation of responses to bitoic and abiotic stresses.", "AFDB_id": "AF-A1XGB4-F1-model_v4" }, { "swissprot_id": "Q0RRR5", "sequence": "MGQKVNPHGFRLGITSEFTSRWYADKQYKAYVGEDVKIRKMMSRGMERAGISRVDIERTQGRLRVDIHTARPGIVIGRRGAEADRIRGDLEKLTGKQVQLNILEVKNPEVDAQLVAQGVAEQLSSRVSFRRAMRKAMQTAMKGGAKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGFYEARTNFGRIGVKVWIYKGDIVQSRAEREAQEALQRQTRRDRPRRGPRSGSSGTTQGGTDAGRAAARSERRGRGGNAPAAETAASEAGATESTAPESTAPESTAPESTAPESTAPESTAPETTAPEAASSPAPAAESTAPATAASESAATPAAAATPGTPEKAEE", "function": "Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.", "AFDB_id": "AF-Q0RRR5-F1-model_v4" }, { "swissprot_id": "Q9GZ01", "sequence": "MGIKGLTKFIADAAPNAIKEIKIESLMGRIIAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIRLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRKQNEEAKKLLTLMGIPIIEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNANATSNQNKNKNNSKRGYILTEINLEQVLKGLNLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIEKIIENIDQNKYQVPSNFRFQEARKSFINPNVLPKEDIKIDWNEPQIEELKHFLIKDYNFNELRVTNYINRLLKARKVTTQRRLDNFFTACTKKSTKLIVEETKKEQTLPARKGKKRPTAGDKNKQKAVKRKIEQANANGHHKMKEENKSVDNEKNEDGIKSVDNEKNEDGIKSVDDEKNLDDEKNLDDEKNKDDEKKSLDNFSSNLFDSDKESESGNIIKNEKQNMDDEKINDNLPSLFGDHSRIRHTENKDNISDINNNNNNNNNNSSSNNNNISNNHFNSVSSNSTFNSSTKLKSEDTLKSNSPLKEDSPNSYNNIKNNNHTININSQINNHKEPISNNNLNNINNSTEIKKKNTLFLLPFCPKDVTNVKKKKYTQRC", "function": "Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.", "AFDB_id": "AF-Q9GZ01-F1-model_v4" }, { "swissprot_id": "Q62170", "sequence": "MSPSFLVLLTILGPGNSLQLQDPWGHETKEAPGPVHLRERRQVVGDDDFEDPDYTYNTDPPELLKNVTNTVAAHPELPTTVVMLERDSTSAGTSERATEKIATTDPTAPGTGGTAVGMLSTDSATQWSLTSVETVQPASTEVETSQPAPMEAETSQPAPMEAETSQPAPMEAETSQPAPMEADTSQPAPMEAETSQPAPNEAETSKPAPTEAETSKPAPTEAETTQLPRIQAVKTLFTTSAATEVPSTEPTTMETASTESNESTIFLGPSVTHLPDSGLKKGLIVTPGNSPAPTLPGSSDLIPVKQCLLIILILASLATIFLVCTVVLAVRLSRKTHMYPVRNYSPTEMICISSLLPEGGDGAPVTANGGLPKVQDLKTEPSGDRDGDDLTLHSFLP", "function": "A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.", "AFDB_id": "AF-Q62170-F1-model_v4" }, { "swissprot_id": "Q9HJT0", "sequence": "MLNIIGVGLRGTGSITFDEFDALRTSDFVYADMYTSIGQPGLIRKISAMIDRDILPLTRDEIENGSILPQAASKNVSLIVVGDPLMATTHNELRYEAMNQGIGVRIFENASILNAAIGKAGLMVYKVAPPVSLPRISEKFFPLSVIDKIKRNADLGLHTPVLIDLEDQENIPLHDALASLLEMERRREYSGIIREICVLSRISFPDEKILFGRIEDMMQQEVNSPYMMFILSKLDDNERRFLSLFSESVSKVSDARS", "function": "S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.", "AFDB_id": "AF-Q9HJT0-F1-model_v4" }, { "swissprot_id": "Q10653", "sequence": "MLRATNNRRTSNNVEKDSLQMAKHGNGPLKPVNAQGLQTKREAREILALKPSNPAPVETAQKSQRINLQDAETKCLAMADDIYKYLVHHEKKYLLEECFMEGGEPTPKMRRILVDWLVQVHVRFHLTPETLHLTVFILDRMLQKKVTSKADLQLLGISAMFVASKFEEVYLPDIHDYEFITENTYSKKQILAMEQTILNSLNFDLSCPSSLVFLRCLSRILSENDASPIDNQAFCYTYNISKCLGELALLDSVMASTPRSHIASASMIIALEVHPVDGIEAENAVSVICKQLGASKKVIEDAVALLAEVSYKNFKQGKLVAIKNKYQSSKLAQVSNLMTDDVLEKINRMGQNAKVDASEME", "function": "Essential for the control of the cell cycle at the G2/M (mitosis) transition.", "AFDB_id": "AF-Q10653-F1-model_v4" }, { "swissprot_id": "Q9SEU7", "sequence": "MAISSSSSSICFNPTRFHTARHISSPSRLFPVTSFSPRSLRFSDRRSLLSSSASRLRLSPLCVRDSRAAEVTQRSWEDSVLKSETPVLVEFYTSWCGPCRMVHRIIDEIAGDYAGKLNCYLLNADNDLPVAEEYEIKAVPVVLLFKNGEKRESIMGTMPKEFYISAIERVLNS", "function": "Thiol-disulfide oxidoreductase required for maintaining symplastic permeability in the meristem. Involved in redox regulation of callose deposition, plasmodesmata cell-to-cell communication and meristem maintenance.", "AFDB_id": "AF-Q9SEU7-F1-model_v4" }, { "swissprot_id": "Q8W2F1", "sequence": "MSLTMADGVEAAAGRSKRQNSLLRKQLALAVRSVQWSYAIFWSSSLTQPGVLEWGEGCYNGDMKKRKKSYESHYKYGLQKSKELRKLYLSMLEGDSGTTVSTTHDNLNDDDDNCHSTSMMLSPDDLSDEEWYYLVSMSYVFSPSQCLPGRASATGETIWLCNAQYAENKLFSRSLLARSASIQTVVCFPYLGGVIELGVTELISEDHNLLRNIKSCLMEISAHQDNDDEKKMEIKISEEKHQLPLGISDEDLHYKRTISTVLNYSADRSGKNDKNIRHRQPNIVTSEPGSSFLRWKQCEQQVSGFVQKKKSQNVLRKILHDVPLMHTKRMFPSQNSGLNQDDPSDRRKENEKFSVLRTMVPTVNEVDKESILNNTIKYLQELEARVEELESCMGSVNFVERQRKTTENLNDSVLIEETSGNYDDSTKIDDNSGETEQVTVFRDKTHLRVKLKETEVVIEVRCSYRDYIVADIMETLSNLHMDAFSVRSHTLNKFLTLNLKAKFRGAAVASVGMIKRELRRVIGDLF", "function": "Trancsription activator, when associated with MYB75/PAP1 or MYB90/PAP2.", "AFDB_id": "AF-Q8W2F1-F1-model_v4" }, { "swissprot_id": "C4JUE5", "sequence": "MLLSSLISLALLSSQVVADPAWAPPDKGLKPEVARLLPPFLRYRRPIYAIAHRVVTVGGIKDAISHGANAFEVDMCADSIGEGWWANHDCTNGRKAGDSARKIFETFAAERKRGKTVTFVWLDFKNPDACVKNQGCSIEAIQQLCRDILEKQGIRVLYGFYKAEDSRAFKTIRNNLNDREAISLNGATTKVLKLFEGTAPKVSKHQRVMDYGDTYLDKGFGDCTEKDWYTCTELRQGADLRRKGKLGKVFAWTSTVNQGRLVDQLLGKAHVDGIIYGFKLTDYYDHADSRAAANDIISWVKRRRALYYMATNDNNPWIDIHKLFLYLLSWFSCILLLMMNEWTCPQDGA", "function": "Catalyzes the hydrolysis of sphingomyelin. Sphingomyelinases D are produced by some spider in their venoms, but also by arthropods such as ticks, or pathogenic bacteria and fungi. They might play a role in pathogenicity through different mechanisms, such as membrane destabilization and host cell penetration, but also pulmonary inflammation and cutaneous lesions.", "AFDB_id": "AF-C4JUE5-F1-model_v4" }, { "swissprot_id": "P87122", "sequence": "MSKTSCFLKKYRLILLWCILGIAYILFWTHRISKAFASVSSTSDSTVHLFERGNTLNDSNDQILLTCNDIKNITPANQCRFAKAYCKGEASGFFDYVEFYFCTINSLRFPVLSIIVGWLIFLFITIGISASDFFSTNLVTISWLLQLPDSVVGVTFLALGNGSPDILSTFAAVRVNSGGMAIGELLGSAFFIVAIVAGSVCLIKPFKIPRRHFLRDVAFLTGTILLVIMFVLHDGSLSIWQSLVMILYYLLYVLFVFFSGSSGVSVVITDENYLPVSLPVYSPVLNSFDDSDSYSSTDSELSEEAFLLPAQASRKTQKIHYINDNDPSNSYSSYQHSHVHDFIHKNNTHSNRVLSQSSGPIVRPSLLAALDFRSSNEEQHPGLRSLDPLNIQDGDLTMHPMHIRHSQSDFYPSGINTPVSGINYPNLGFSANNSVQSLVSEIFRHPTHTDEDFPLPSPSLSSLLFPTLRNFAKKSWYEKLMDVLAVPSVLIFTLALPVYQCPRLAVDPIYHMDVSNCNPSKPTWSRKLRLLQCVFVPFAFVTFSITGGNRLYIYAASSVFSILCITALYYYTDEEKPPKFLPWVSFIGFVLGIIWISTIANEVVGILRALGVIFNLNESILGLTVFAAGNSLSDLIADIMIARSGFPEMAMGGVFGGPTLNILIGIGISSFYSSISNHGNDSVIEIPHSLSITAYFLLACLLLLLIYVPLNRFRVNRVLGLLLFILYIVGTSTNIVVELLKDK", "function": "Putative cation exchanger.", "AFDB_id": "AF-P87122-F1-model_v4" }, { "swissprot_id": "Q6QHK4", "sequence": "MDPAPGVLDPRAAPPALLGTPQAEVLEDVLREQFGPLPQLAAVCRLKRLPSGGYSSTENLQLVLERRRVANAKERERIKNLNRGFARLKALVPFLPQSRKPSKVDILKGATEYIQVLSDLLEGAKDSKKQDPDEQSYSNNSSESHTSSARQLSRNITQHISCAFGLKNEEEGPWADGGSGEPAHACRHSVMSTTEIISPTRSLDRFPEVELLSHRLPQV", "function": "Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.", "AFDB_id": "AF-Q6QHK4-F1-model_v4" }, { "swissprot_id": "Q46QQ8", "sequence": "MDTATKTGYADVLVGLQYGDEGKARVVDHLAAGYDVIARFNGGANAGHTIATSEGILRLRQVPSGVLHPRVSLYIGSGCVIGLRQLASEIEMLAGQGIDLAGRLTISDRCPVVQPAHFLSDRRDGGRIGTTGNGIGPCYADLAARMRGGERSAFQLCDLMRDESRVFEQMMRLAAQRDDEDIAVLIQEMRQAWQVVRPFVTDNPVALLERVEGGARVLFEGAQSVMLDVVQGAQPWVTSSHTLPSYAYVGGDLPCRYHRKTIGVAKAMVSRVGSGPLPTELGAERSEAYCADAGREGRGRADEAARFDPRALLAQGDAFSTGIAIRMLSNEYGTGTGRPRRVGLLDVAQLQLAIRQFGVDEVYLNKCDSLAVFAQTRDRCIPVVVGSRDGNAMHVMRFPAFDESVIPRDDATPLPPQLETLLEWLADVLGRPLRGIGLGPQRAQMRLFKTQP", "function": "Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.", "AFDB_id": "AF-Q46QQ8-F1-model_v4" }, { "swissprot_id": "Q95ZV7", "sequence": "MKLLLYLFGVTFHSNTVVALELRECSHQLGMSNRKIRDEQISASSSFDLQSTGPQHARAHQESGSGAWCPKNQINSLSKEWLQISFSVDTVITSVETQGRFDDGRGMEYATAFKIQYWRPSLNAWASYKDDFELETIPANNDTEHAIRRHLDRAIIARRIRIVPVSNSTRTVCMRVEVFGCPFDDSLVFYNVDQGDLQSGISYHDFSYDGNLANSPHLTGGIGKLYDGEVGKNNVFVNHHKWVGWRRKRNGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFSSATVLFSINGKDFSDTIVHFNNPEDTESEVPRWIRIPVNNRIAKVAKIRLNFGTDSDWLFISEVNFESNHTNIELLNDDVVIPDSVSYFSVTEHDDGTSMFAFIIFFFMFLIVAVIILTVLYRKREYRVKASSPSPNAKREILLTIDGNTIKHHVSPSTYQMARDNLQNALIEKMPMSPIISDYAEPDISVCSDVTANTPLLYGIDGPYDTQKRSNPLSSMVKYSDYGEVYCTTLPEIARDKLICVSRIGQGEFGEVDLCQLENRKVAVKKLHGISQADEFSFHREIRVLGSLKHPNVVEVVGVCTIQKPILCIMEYMENGDLKSYILKNPTIQTSQCISICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVEGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQSLVHTSPHIHF", "function": "Tyrosine-protein kinase receptor which, together with ddr-1, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. Acts upstream of the adapter shc-1, and the tyrosine kinase receptors svh-1 and svh-2 to regulate axon regeneration following injury in D-type motor neurons. May mediate axon regeneration in association with the collagen emb-9.", "AFDB_id": "AF-Q95ZV7-F1-model_v4" }, { "swissprot_id": "P52302", "sequence": "MSLKLMAFVCALLLLCTLTHVLSAATTVRPYKFGFTIDEQQHRAEKRDERGIIMGEFGFITADGIYHVTVYATDEEGKFRIISMKSYPYAGPVGSKSVPVTTTPKVLLPAAPVALPKYNFNSEACSGCFLKKSPPKTEIRTLSQPLAPVQPGKPDGSSDIGLNVQLPFRESIAQTVASRLGLLQDTLQTSNTNTNAPNTKTIELGLNIAMSTYYTTKNAVTGHVSTQTSNSQTPSANTKIDYNVGVVEKASPPVYRPLNIRLNEDVMRQAITYGNTIPGHVPLPNQPLVETSLLPASQVKIFALDGNAKVPLASNIQSVAQHPNAGLNAKVPLASNIQSVAQHPNAGLNAKVPLASNIQSVAQHPNAGLKNINRSGVSSAKTLANTKTRPPHTFNPHQTPLLSSATAPGISGVTANTPTGNVPSNGGGIAAGKAPGNPQAGGSGGIIGAGAPGGRKVSAGGIGSGSAIGGVSGGSKASGNGGAIGSGSAIGGGATGSKASGFGFGSNIGGGVSGSKPSGFGSESKIGGPDSGSKALGFGSGSKIGGGITGTKASGFGGEIGSGRGSASSATGDLYKFKYILDYNGHEETGGRNGDKQGSYFAIGEDAVQRTIEYIANEFGFQPHVSWRKLDAKEALPEENSLKHYEFKWFNQE", "function": "Required for differentiation of the phagocytic blood-cell type, the plasmatocyte.", "AFDB_id": "AF-P52302-F1-model_v4" }, { "swissprot_id": "Q93LQ6", "sequence": "MRKVLLIASIVALILALFSCANPSFEPRSKAKDLASLPEIKSQGYHILFGELRDGEYTEGKILVGYNDRSEVDKIVKAVNGKVVLELPQIKVVSIKLNGMTVKQAYDKIKALALKGIRYVEPSYKRELIKPTVVKPNPDMYKIRKPGLNSTARDYGEELSNELWGLEAIGVTQQLWEEASGTNIIVAVVDTGVDGTHPDLEGQVIAGYRPAFDEELPAGTDSSYGGSHGTHVAGTIAAKKDGKGIVGVAPGAKIMPIVIFDDPALVGGNGYVGDDYVAAGIIWATDHGAKVMNHSWGGWGYSYTMKEAFDYAMEHGVVMVVSAGNNTSDSHHQYPAGYPGVIQVAALDYYGGTFRVAGFSSRSDGVSVGAPGVTILSTVPGEDSIGYEGHNENVPATNGGTYDYYQGTSMAAPHVTGVVAVLLQKFPNAKPWQIRKLLENTAFDFNGNGWDHDTGYGLVKLDAALQGPLPTQGGVEEFQVVVTDAKGNFGVPTVFVSMMRDNGSCYYAKTGPDGIARFPHIDSGTYDIFVGGPDHWDRALAPYDGESIPGGYAIALRMAEERQASFVGFGVSPDATQLNVNFNSTLQVKFSTNLSTLKDPQFVVVDPLLRGVYGRVAYARNQTYDLSLLSGQISFGIQTLLPAATDITIQGTVTLNGEDIPVYGVLKAGTTWTIIDDFGGLNLGTDSQPIYVWWTIFGQ", "function": "Protease able to degrade keratin into peptides. Is responsible for keratinolysis by F.pennivorans, which allows this bacterium to grow on native feathers.", "AFDB_id": "AF-Q93LQ6-F1-model_v4" }, { "swissprot_id": "Q6BNJ4", "sequence": "MDCVNISWFLITLFAAIATSTMHDGENNNVGKMLQEPTYLQSEMIESIMSRHLESFSLTESDFEDIIFMKPRSKCVKDALKDIIPECMRLGVDSIEPGLQKKAAIQLSICEFENSKVTYPSSCYNMINDNDFDSCIFDIERAPQYWTTFSGYYREITKICYEESLPFEKEQIISLYSNITKLYSKMFQDLNDSYKDSTHIQQMMKNEFKELQRMMKVILDQNEKTSEEVKEKYEEFSEQYSSMLSTSLEISKKFSLGTENLVEDMANNIKYLDFELSRISIAIEDLDFETKLTDMKNSVLDDVRNLSDESISLLDSILTNLESLDILSQDAQNITNGISQSLKKNEVLSNNMNNALIETDTQLHEHNEVIRFEFEETISYLSQFSDQAIDNAIRDTSEEITKHVATFIDSINLRLEETTTKLEEVIYNIDDLSDKVGNASSYLIEGLNLLTSNGIMDALLLTYNNVASGLESGFGMLTTLKSDIFKIVRFITACILFAILFIWSMNRLFSQNRTKHTTLSSISPIGILNFRRIFRFLTNLALWLSVMGGTLLAVIVTNFLIQLKVYISKLSTND", "function": "Required for nuclear membrane fusion during karyogamy.", "AFDB_id": "AF-Q6BNJ4-F1-model_v4" }, { "swissprot_id": "P19906", "sequence": "MDTSLPSAILNNMVTATLILDDGLAIRYANPAAELLFSQSAKRIVEQSLSQLIQHASLDLALLTQPLQSGQSITDSDVTFVVDGRPLMLEVTVSPITWQKQLMLLVEMRKIDQQRRLSQELNQHAQQQAAKLLVRGLAHEIKNPLGGLRGAAQLLEKMLPDPSLTEYTHIIIEQADRLRALVDRLLGPQKPGKKTQENLHQILEKVRQLVELESQRSIVIERDYDPSLPEILMDADQIEQAMLNIVSNAAQILSHQEHGKITIRTRTVHQANIHGKRCKLAARVEITDNGPGIPPELQDTLFYPMVSGREGGTGLGLSISQNLIDQHNGKIDVESWPGHTTFTIYLPILR", "function": "Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.", "AFDB_id": "AF-P19906-F1-model_v4" }, { "swissprot_id": "P40157", "sequence": "MNILKKFMESGNKPELITIPSGQFNLLRSKNSPKAALECIYNNATLSVRKIGKFDYELAVYRVEDDSEGGTGDEAENFEDDTISVLSTQSKKKEEEWSVEISDKIMFHKTWDKQGNVALVWENLRGDEQDEKVQFVVAADVSFSDVEQFIQTVYRCQFEVRNKKSSLTASADDLKEIEHRSTRLFVQDDDDELDSSSDDFQDAKDTSFEHEKESEILERTPSPLKKVPEGEYCCLVMSSLYMYDPIQEKFILQEPVVKVAIIDTGKYEFWLAIEGKDNRLGTQVAPNINPTFELATDAFLFNYTLQNITLSYMLKFKDLDKCIQFRFAWVKCLWMTLNKETWTDVPEKEKDYILDSSSVPLEKQFDDILHIDDRSNEERDKESSESENDSEDEDDENDHSKRIISSEAFEEPRRATSKGNSSLTVAFRNNRSYVTRDNRIGVFKTDDEDDSLEFVAAIKNISNLGGKSIDPHKPMLYMEDRNLILTDGENENKLYKMDIERGKVIEEWSTGDKNVVQYGPTKKFDQMTPEQTIVGVSQKGVFKIDPRINGKNKIAVDESKDYVGKYNFSSIGTTESGYIAIGSEKGDIKLYDRLGIRAKTAIPSLGQAIKFITTSADGKWLLATCESTLLLMDLKIKDGKNAGNIGFLKSFPASENVKTYVLKIRPEHSASILTYTKKPIRFTKAYFNTGIGQQEQTIVTSTGPYAISWSLKGILNQDGSNNYPYRIRRYNADVVADNFEFGSDKKVIVALKDDVSLSKVKSFKQPSKGVLMPSASLQDFYG", "function": "Has a role in the negative regulation of gluconeogenesis. Required for vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase).", "AFDB_id": "AF-P40157-F1-model_v4" }, { "swissprot_id": "Q94KK6", "sequence": "MPVIDIIFRVDEICKKYDKYDIDKHREIGASGDDAFSRLFTSIDSDIEAVLRKAELASTEKNRAAAVAMNAEVRRTKARLAEDVVKLQKLAVKKIKGLTREERESRCDLVIALADRLQAIPDGNEHGAKQANSDWGGASAPNKNIKFDMSEEDMDDGFFQQSEESSQFRQEYEMRRKKQDEGLDIISEGLDALKNLARDMNEELDKQVPLMEEMETKVDGATSDLKNTNVRLKKQLVQMRSSRNFCIDIILLCVILGIVSYIYNALN", "function": "Vesicle trafficking protein that functions in the secretory pathway.", "AFDB_id": "AF-Q94KK6-F1-model_v4" }, { "swissprot_id": "Q03233", "sequence": "MAIKPTKSFQNCLEAEVPGYNDCPTVLFSIDPNSGPRSKSKQRTKSKRCVSGRLATEVLDLYGNTKTATTPPPVLRRPSVTAAQQESACEGVLVKDQGDRQLQPILCSKEELVAKINDLCVCGSKLSSKELEFYKKKLDSNITKILQNEHTKTVLSQIFNEKDKNMAVKTIKHWMVTDTTISNWCPAFLKIFENAMPN", "function": "Involved in ER-associated protein degradation (ERAD).", "AFDB_id": "AF-Q03233-F1-model_v4" }, { "swissprot_id": "P43614", "sequence": "MAGIKLTHKLYQYYQLATSFLYAALLIRWLILMPLVGSRFLPGGIHEFLIYLMFYSSIMEVIWLLRFHGFKYGLLSRTFLKDLNFIYLVSVIHFYDDYEHALILKNASYSSFIISLSLSQAYCHWCKLFKRKGVKERTLVWKVNTFVTLPILYLSEFALLLLNIQVKNYHSTPTLDIINRVVLLAYFPVLLTAYKKLLTK", "function": "Involved in the biosynthesis of (1->6)-beta-D-glucan polymers of the cell wall. Required for viability. Involved in maintaining chromosome stability.", "AFDB_id": "AF-P43614-F1-model_v4" }, { "swissprot_id": "P29484", "sequence": "MNIKLSFISIAFLSLSFNVAANEFEKSQEHYKSVTDLKNKIEILELEKKITELSGEIRNARMPKIDKSAPVLSPQPVVKSSEELQKSIEHIEEELKVELAYLVNNGQQKKYTFNLNGKLITLVNGDFVNGWKFIEDQNKIQFSKGNKVIDVN", "function": "The toxin coregulated pilus (TCP) is essential for successful colonization of the small intestine.", "AFDB_id": "AF-P29484-F1-model_v4" }, { "swissprot_id": "F4HU51", "sequence": "MNTESVVEFLGNVPLLQKLPSSSLKKIAQVVVPKRYGKGDYVVREDQTWDGCYFILQGEAQVSGPDEEDNRSEFLLKQYDYFGVGLSGNVHSADIVAMSQLTCLVLPRDHCHLLETNSIWQSDTSLDKCSLVERILQLDPLELNIFRGITLPDAPIFGKVFGGQFVGQALAAASKTVDFLKVVHSLHSYFLLVGDIDIPIIYQVHRIRDGNNFATRRVDAVQKGNIIFILLASFQKEQQGFEHQESTMPSVPDPDTLLSLEELRESRITDPHLPRSYRNKVATRNFVPWPIEIRFCEPSNSTNQTKSPPRLNYWFRAKGRLSDDQALHRCVVAFASDLIFCGVGLNPHRRKGVKSAALSLDHAMWFHRPLRADEWLLYVIVSPTAHETRGFVTGQMFNRKGELVVSLTQEALLREARPPKPSGTSKL", "function": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Active with both medium chain and long chain acyl-CoAs (e.g. 12:0-CoA, 14:0-CoA, 16:0-CoA, 18:0-CoA, 16:1-CoA, 18:1-CoA, 18:2-CoA and 20:4-CoA) as substrates, palmitoleoyl-CoA (16:1-CoA) being the favorite substrate.", "AFDB_id": "AF-F4HU51-F1-model_v4" }, { "swissprot_id": "Q8R149", "sequence": "MAAAPPLTKAEYLKRYLSGTDAGLEGGPEAGRKRRKKRPKPGGAGGKGMRIVDDDVGWAAISTAKPEKEEEEDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHGEDGHFHHDDQDSSPPRRVRHDTPDTSPPRKARHDTPDPSPPRKARHDTPDTSPPRKARHDTPDPSPPRKARHDTPDPSPPRRVRHDTPDLSPPRRVRHDTPDLSPPRRVRHDTPDPSPPRRVRHDLDASPPRKSHRNSSAVSPRRGHHGSLGTSSPRQTHNHSPTAAQHRRTLDSSGTQHLRRAHHESPDLELHKAKSSKAAERAPSKAASQSGLGPSHPSLSTNSKYEHDSDLSPPRKRQAKAHFEAKKQLDSKGVYQKASDSDLSPPRKKKNSGHQDSDSDLSPPRNRPRRQSSDSDLSPPRRRQRTKSSDSDLSPPRRSPRPGKKTAHMYSGAKTGLVTDVQREHQELKKQDQDTTDLGAQFEFTETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKKVKPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLASKKAVEELAYKWSVEDM", "function": "Involved in pre-mRNA splicing as component of the activated spliceosome.", "AFDB_id": "AF-Q8R149-F1-model_v4" }, { "swissprot_id": "Q9D7S0", "sequence": "MRGVFIAGVIAAFAITVVDSLNCTQCYTYNSTCDGQATECNEQSFSCVESSINSTLGGFLHVYQNKFCSASNCTENSTEVAFTVHLFDDQRYHFASQCCQGESCNATHSESGTQNVTDMQCMSCYGHNKTLCEEKPQKCYEGEQCVFIIAEMVNGSGRVELKGCSDISNSTCQFLSPGNTTVGEFVFKSVECTQPTEYTNSTTTIPPITNTSLTSVTRPGIKTSPASVTPQASMGTKASFTSSIFGSLLLLKLLF", "function": "Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.", "AFDB_id": "AF-Q9D7S0-F1-model_v4" }, { "swissprot_id": "Q9FIY7", "sequence": "MAIVDDAEMRLTESEAVSSSDDRKIVADTPDFIDESSLVIRTTTGVRISALPAEQSLVDSDGSNSEVTLPAKDEVISDGFTCVNKEIVESDSFREQNLEIGEPDLDVENRKEAMIIDSIENSVVEIVSSASGDDCNVKVEVVEPELLVENLVVAKEEEEMIVDSIEDSVVEIVSTASGCDCNVKVEVVDPELCVDNLVVVKEEEMIADSIAESVVETVSRGLDYECVDVKVKEEPDLGTKLEEDSVFPNVLEKKDEVIKVLEDQPSEINKKLEQENDDLFSSGDSDGTSAKRRKMEMESYAPVGVESCILAPTPLRVVKPEKLDTPEVIDLESEKSYTHVKMEPVEEIKVEAVKMSSQVEDVKFSREQKSVYVKKEPVGARKVKVEDGDFPVEKDWYLVGRSLVTATSTSKGRKLEDNEIVNFTFSSVAKWKVPNIVRFSTKRCGEIGRLPMEWSNWAVSLLRSGKVKMLGRCVAAPPFLTMMQEIMLYVSFYIHSSIFTDVSKSTWRIGSSPNLESTLHPLLQLFKHLTIKPYQKAEFTPEELNSRKRSLNLEDDYDERAALLAIAKRRKGCQQSLEQNKDEEEAPESYMNRVVGAADSYNLEEMEAPSTLTCNLRPYQKQALYWMSESEKGIDVEKAAETLHPCWEAYRICDERAPSIYLNIFSGEATIQFPTATQMARGGILADAMGLGKTVMTIALILARPGRGNPENEDVLVADVNADKRNRKEIHMALTTVKAKGGTLIICPMALLSQWKDELETHSKPDTVSVLVYYGGDRTHDAKAIASHDVVLTTYGVLTSAYKQDMANSIFHRIDWYRIVLDEAHTIKSWKTQAAKATFELSSHCRWCLTGTPLQNKLEDLYSLLCFLHVEPWCNWAWWSKLIQKPYENGDPRGLKLIKAILRPLMLRRTKETRDKEGSLILELPPTDVQVIECEQSEAERDFYTALFKRSKVQFDQFVAQGKVLHNYANILELLLRLRQCCNHPFLVMSRADSQQYADLDSLARRFLDNNPDSVSQNAPSRAYIEEVIQDLRDGNSKECPICLESADDPVLTPCAHRMCRECLLTSWRSPSCGLCPICRTILKRTELISCPTDSIFRVDVVKNWKESSKVSELLKCLEKIKKSGSGEKSIVFSQWTSFLDLLEIPLRRRGFEFLRFDGKLAQKGREKVLKEFNETKQKTILLMSLKAGGVGLNLTAASSVFLMDPWWNPAVEEQAIMRIHRIGQKRTVFVRRFIVKDTVEERMQQVQARKQRMIAGALTDEEVRSARLEELKMLFR", "function": "Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for DNA repair. Does not seem to be required for DNA repair and regulation of homologous recombination (HR).", "AFDB_id": "AF-Q9FIY7-F1-model_v4" }, { "swissprot_id": "Q9KBU1", "sequence": "MGIKIGHASFDERVEKGIDNLFMRQAVSSAQERLKLAKAKAEEELGDWQEWRTLAEEIRSHTLDNLDYYLEQLSDNVSKNGGYVYFAQTAEEANVYIKEIAMKQQAKKIIKSKSMVTEEIGMNQALESIGCEVIESDLGEYILQIDDHDPPSHIVAPALHKNKEQIRETFKEKKGYSKSANPQELTLFAREQLRKEFLQADIGITGCNFAVAESGSITLVTNEGNARLATTIPKTQITVMGMERIVPTWEELDILVSMLCRSAVGQKLTSYVTGLTSTKEAGDVDGPEEFHLVIVDNGRSNILGTEFQAALHCIRCAACINVCPIYRHVGGHSYGSIYPGPIGAVLTPLLEGYDDHEELPYASSLCAACTDACPVKIPLHELLIKHRRVIAEQEKRTPLSESLAMKGFGLVASQPNLFKMGTKGAPYVLSPLTKDGSIKKGPGPLKGWTDIRDLPAAKKERFRDWFKTRGKGNIHHDSTTRDLSQ", "function": "Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate.", "AFDB_id": "AF-Q9KBU1-F1-model_v4" }, { "swissprot_id": "A0A067XMP1", "sequence": "MKHIVIIGGGFAGVSTAHRFLKNVGKSTTAPYKVTLVSRDSHFFWNIAAPRGIIPGQIPEEKLFQPIAEGFSQYGPDKFEFVLGTATDLDVGGKTLVVDVDGKATRISYDYLIIGSGSRTKIPGPFKSDGSTDGVKQTIHDFQERVKAAKTIVVVGAGPTGVETAGELAFEYGTSKKIILISGGPTVLENRPASVTKTALKQLETLNVDVRVNTKAKDPVTLPDGKKELTLSGGEKLVVDLYIPTFGVLPNSSFVPSQYLDSNGFVQVDQYFQVKGAEGVFAIGDVSDSEAPQFWFVEKQSVHIAKNLILSLSGKAPTPYKASATGMMGLQIGKNSGTGHFGNFKLPGFLVKTIRKTLFVENLPKTVDGSML", "function": "Oxidoreductase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes. The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA. As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain. The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone. Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC. Spontaneous decarboxylation of endocrocin occurs to generate emodin. An O-methyltransferase (ptaH or ptaI) could methylate emodin to form physcion. PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin. PtaF, a putative NADH-dependent oxidoreductase, might also participate in the oxidative cleavage step. Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin. Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin. PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulochrin and chloroisosulochrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination.", "AFDB_id": "AF-A0A067XMP1-F1-model_v4" }, { "swissprot_id": "Q9V2H7", "sequence": "MAYRFIKWFEELRKEDVPLVGGKGANLGEMTNAGIPVPPGFCVTAEAYKYFVENVKISKEDVKRILGEKANKGTIAEVLAQAPDEPRPLQEWIMDIINRTNVDDSKQLQENTAVIRELIKSLDMPAEIADEIKQAYKELSQRFGKDEIYVAVRSSATAEDLPEASFAGQQETYLDVLGADDVIDKVKRCWASLWTARATFYRAKQGFDHSKVYLSAVVQKMVNSEKSGVMFTANPVTNNRNEIMINASWGLGEAVVSGAVTPDEYIVEKGTWKIKEKVIAKKEVMVIRNPETGKGTVTVKVAEYLGPEWVEKQVLTDEQIIEVAKMGQKIEEHYGWPQDIEWAYDKDDGKLYIVQSRPVTTLKETTTEEVEEVEEAEVILKGLGASPGIGAGRVVVIFDASEIDKVKEGDVLVTTMTNPDMVPAMKRAAAIITDEGGRTSHAAIVSRELGIPAVVGTKEATKKLKTGDYVTVDGTRGLVYKGIVKSLVEKKKKEEAAAAPGAAVAAAPLVTGTLVKVNVSMPEVAERAAATGADGVGLLRAEHMILSIGQHPVKFIKEGKEEELVEKLAEGIEKVAAAFYPRPVWYRTLDAPTNEFREMPGGEDEPEERNPMLGWRGIRRGLDQPELLRAEFKAIKKVVEKGYNNIGVMLPLVSHPEQIRKAKEIARSVGLEPHKDVAWGIMIEVPAAAIIIEDLIKEGIDFVSFGTNDLTQYTLAIDRDNERVAKLYDETHPAVLKLIKHVIKVCKRYGVETSICGQAGSDPKMARILVRLGIDSISANPDAVQLIRQVVAQEERKLMLEAARKRLFEEEEEEEEFLF", "function": "Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.", "AFDB_id": "AF-Q9V2H7-F1-model_v4" }, { "swissprot_id": "P29131", "sequence": "MAQRDYVRRSQPAPSRRKKSTSRKKQRNLPAVSPAMVAIAAAVLVTFIGGLYFITHHKKEESETLQSQKVTGNGLPPKPEERWRYIKELESRQPGVRAPTEPSAGGEVKTPEQLTPEQRQLLEQMQADMRQQPTQLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASSQQPYQDLLQTPAHTTAQSKPQQAAPVARAADAPKPTAEKKDERRWMVQCGSFRGAEQAETVRAQLAFEGFDSKITTNNGWNRVVIGPVKGKENADSTLNRLKMAGHTNCIRLAAGG", "function": "Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases (Probable). Required for full FtsI activity. Required for recruitment of AmiC to the septal ring.", "AFDB_id": "AF-P29131-F1-model_v4" }, { "swissprot_id": "O70493", "sequence": "MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRHPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVAGKVLGEKDC", "function": "May be involved in several stages of intracellular trafficking.", "AFDB_id": "AF-O70493-F1-model_v4" }, { "swissprot_id": "Q9YAD8", "sequence": "MPVEVIPVLHNVSSVQRVVDMARLSYSLGLDTLVVTKAYGGAAQSGVPEAMRLALKLGKSLVVLPELRDAVNLLSPTHVLAVTPSRAERLVGPGGLEGLEGRVLVVFSGGEPELDPSEAAGAIRVYIEGVEGKVGPIAEAALILYFLLRGGGDGRG", "function": "A putative type II restriction enzyme, its methylase would be APE_2002.", "AFDB_id": "AF-Q9YAD8-F1-model_v4" }, { "swissprot_id": "A0A0B4LFY9", "sequence": "MAIASNVVEAGNAVRAEKGRKYFYFRKMIGDYIDTSIRIVATVFLADLLLRLYRCVVEYGSNGRYYLPEDRLWIILRRSCTYNNRSIYLIVGFLLVAFFRISVTGNYRNVMPTTLFLFQMPLYWIWSFTDMDQSTLSYSHWIRDSHGLDYAAGMASNYFHGYLKLSLPERKDDGLKHRLAMYEDKNNVTFGIKRLVILIPDEMFVNGVLESHLLDKAEPLETQFINRAGVYRPFKHDVYRMNKKVNGRTYYFAVEGATPMISFFDATYSNLSGTWQMQELKREIWIKFYKHLKELITTWPETRDLVELIIYNSHDSKGNLVDVGELLVAHMQNKTKTIDEISN", "function": "Facilitator of innate immune signaling that binds cyclic dinucleotides produced in response to infection by bacteria and/or viruses, and promotes the activation of the NF-kappa-B transcription factor Rel (Relish). Recognizes and binds cyclic di-GMP (c-di-GMP), a cyclic dinucleotide messenger produced by bacteria such as L.monocytogenes, leading to activation of the peptidoglycan recognition protein (IMD) signaling pathway and activation of Rel (Relish). Innate immune response is triggered in response to double-stranded RNA from viruses delivered to the cytoplasm: Sting acts by specifically binding cyclic dinucleotides 3',2'-cGAMP and 2',3'-cGAMP produced by cGlr1 and cGlr2 in response to RNA virus in the cytosol. Has a strong preference for 3',2'-cGAMP compared to other cyclic dinucleotides such as 2',3'-cGAMP or 3'3'-c-di-GMP. Upon binding to 3',2'-cGAMP, activates an antiviral immune response, leading to the activation of Rel (Relish). Activated in brain in response to Zika virus infection, leading to autophagy.", "AFDB_id": "AF-A0A0B4LFY9-F1-model_v4" }, { "swissprot_id": "O60020", "sequence": "MISDTVIAILAVALVGSTVQAAPVDATATSTSGIIAVPISKSAAQLAREADPVVSLDWLKKTKAQAQYKHKQANARLHSKRATGASVLTDQGSESLWTGPITIGGQSFTVDWDTGSSDLWVPSSACSSAACNAHHKYTLTSTGKKQSGTFSISYGDGSSASGPVYKDNVVASGLQATSQVFGAVTSESSSFSSDPSDGISGLGWPALAQLSGTSYFWSLINQGTVTSPVFSFRLATTNSELYLGGINSAHYTGAITYTPVTQKAYWTIALGGVSVNGAAINPSVSSAIIDTGTTLVYGPTAGVAALYAKIPGSASMADTYGSDYQGYYTFPCSAVPTVALTFGGSSFSVPTSAFNLGTVSSGSKQCVGGIVGQGDGSWLVGDVFLQGVYSIYDVGNARVGFAKTV", "function": "Possesses acidic protease activity. Hydrolyzes casein and azoalbumin in vitro.", "AFDB_id": "AF-O60020-F1-model_v4" }, { "swissprot_id": "Q6ZMI3", "sequence": "MARGAEGGRGDAGWGLRGALAAVALLSALNAAGTVFALCQWRGLSSALRALEAQRGREQREDSALRSFLAELSRAPRGASAPPQDPASSARNKRSHSGEPAPHIRAESHDMLMMMTYSMVPIRVMVDLCNSTKGICLTGPSGPPGPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIPGAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPGETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFIHLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLDERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQFLSTTLNQ", "function": "Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.", "AFDB_id": "AF-Q6ZMI3-F1-model_v4" }, { "swissprot_id": "B8XC04", "sequence": "MFSTTLINTFSLGLLAVVSVVAAPGGISVGPISIGPGGISLGPGGISIGPGGINLGPGGGPGAINAGPAAVNLGTAGNYAILAKSGISTVPESIISGNIGVSPISTTAFTGFSETLDSTGKFATSQQVVGELFAASFAAPTPTTLTTAVSDMQTAFNDATGRVTPDFTNLGGGELGGLVLTPGLYKWTGAVSVNSTGVTIAGTPLDHFIFQIPATLGFAAASRVTLVGGIPASNIVWAATSVVTAGAGSHIEGVVLAKTAVTLETGATMNGRILAQTFVALQSATVIG", "function": "Binds ice crystals and most probably inhibits their growth in order to prevent cell damage from extracellular ice.", "AFDB_id": "AF-B8XC04-F1-model_v4" }, { "swissprot_id": "E9F8M4", "sequence": "MINSDAQSAQKQVEVEKPDEKYSAPRLLPPIPDSYQPAKAITKIPATSSLEDILAILERDGGVILTDFVSLQELDKIDEELEPYTKSSIADDDSYNNFIGKKTLVIPGLVGKSDTIANILDTNETIDKLLKVILEERYPAVFEQHTEELVVDPLLSICMGFHVGHGSPRQALHRDDMIFSSKHRPDMKINEVDGFSCFLAGTRITRENGGTMVILGSHKWEHDRRGRPDEVSFLEMERGSAFIFLSTLAHGAGYNTIPGEVRKITNLVFCRGTLRTEENQFLCVPRSKVLKMSPKMQTLLGFKKPAGSWLGMVENEDPAKDLEAIYEKMLK", "function": "Dioxygenase; part of the gene cluster that mediates the biosynthesis of swainsonine (SW), a cytotoxic fungal alkaloid and a potential cancer therapy drug. Swainsonine production occurs via a multibranched pathway and is dispensable for fungal colonization of plants and infection of insect hosts. The first step of swainsonine biosynthesis is the production of the precursor pipecolic acid (PA) via conversion of L-lysine (Lys) to 1-piperideine-6-carboxylate (P6C) by the aminotransferase swnA, the latter being further reduced to PA by the reductase swnR. PA can be converted from lysine by both the SW biosynthetic cluster and the unclustered genes such as lysine cyclodeaminase. The PKS-NRPS hybrid synthetase swnK uptakes and condensates PA and malonyl-CoA with and without skipping of the ketoreductase (KR) domain in order to produce 3 intermediates, 1-oxoindolizidine, (1S)-1-hydroxyindolizin, and (1R)-1-hydroxyindolizine; with the transisomer (1S)-1-hydroxyindolizin being predominant. The terminal thioester reductase (TE) domain of swnK is involved in reduction of the thioester bond to release the intermediate aldehydes. The oxidoreductase swnN could contribute to the reduction of 1-oxoindolizidine to (1S)-1-hydroxyindolizin and (1R)-1-hydroxyindolizine, contributing to the major route of SW production (Probable). The dioxygenase swnH2 would be responsible for the oxidization of (1R)-1-hydroxyindolizine into (1R,2S)-1,2-dihydroxyindolizine and of (1S)-1-hydroxyindolizin to yield both (1R,2S)-1,2-dihydroxyindolizine and (1S,2S)-1,2-dihydroxyindolizine. The dioxygenase swnH1 then performs the conversion of the 1,2-dihydroxyindolizine epimers to SW.", "AFDB_id": "AF-E9F8M4-F1-model_v4" }, { "swissprot_id": "P14904", "sequence": "MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL", "function": "Resident vacuolar enzyme that catalyzes the removal of amino acids from the N-terminus of peptides and proteins. Also acts as the major cargo protein of the cytoplasm-to-vacuole targeting (Cvt) pathway. The precursor form of aminopeptidase 1 (prApe1) assembles into dodecamers and the propeptide mediates the aggregation of dodecamers into higher multimers. The multimers are then recognized via the propeptide by their receptor ATG19, and ATG19 further interacts with ATG11, which tethers the APE1-ATG19 complex to the pre-autophagosomal structure (PAS). The cargo-receptor complex (also Cvt complex) is selectively enwrapped by a double-membrane structure termed the Cvt vesicle under vegetative growth conditions and by a similar but larger double-membrane structure termed the autophagosome under nitrogen starvation conditions. The Cvt vesicle or the autophagosome fuses with the vacuolar membrane and release its content in the vacuolar lumen. In the vacuole, prApe1 is processed into mature aminopeptidase 1 (mApe1).", "AFDB_id": "AF-P14904-F1-model_v4" }, { "swissprot_id": "Q3UMG5", "sequence": "MAASQGGGGNSGGGGCSGGGSGGGGGAAGGGGGGGGGGGGGAGAGGGGGCGGTVAVPIPVPTLFGQPFPNGPQWHPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLREFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDVSCNEIQVLPQQMGKLHSLKELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLNKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTISLHSQVSESNREQTSRNDSHITGSKPDSQKDQEVYDFIDPNTEDVAVPEEGDTHIGSFVSFLKGKEKSSEKSQKNEEPPNEKKVDKEQLLPEEEDDDLKEVTDLRKIAAQLLKQEQKNRILNHSTSVMRNKLKQTVECEKSVPADEGNSPLSPLAWQPLENQKDQIVDQQWPESQPIIWQNEERRRSKQIRKEYFKYKSTRKNSSGNENEEQESDNAHMSAQSPVSSEEYDRSDGFSHGPFGLKPRSAFSRASRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSMA", "function": "May play a role in the organization of the cytoskeleton.", "AFDB_id": "AF-Q3UMG5-F1-model_v4" }, { "swissprot_id": "Q660S4", "sequence": "MIKRLNNFFEKINIKPQTKNLINYTTYKIGNISKLFLIPKNIQEAENIFKAAIEEKITLFILGGGSNILVNDKEELDFPIIYTGHLNKIEVHDNKIVAECGANFENLCKIALNSSLSGLEFIYGLPGTLGGAVWMNARCFGNEISEILKKITFINDKGKTICKEFKKEDFKYKVSPFQNKNFFILKTELNLKKENKKIIEEKMNKNKQARINKGHYLFPSSGSTFKNNKSFLRPSGQIIEECKLKGLSVGGAEVSKYHGNFIININNATSNDIKSLIEKVKTEVYSKTGLLLEEEVLYIGFKNQKS", "function": "Cell wall formation.", "AFDB_id": "AF-Q660S4-F1-model_v4" }, { "swissprot_id": "Q9XIL5", "sequence": "MTKSNGHNATMIVTGACDFSSSFSLASSSSSTVSVTTFNISSLSSNPNIINSSSTLFRSLSFSLIRHRSSYSRRSLRRLSIHTVHGNKTQFFSHSSTRTPPLFTANSTAQRSGTFVEHLTGITESEEGISEANGFGDVESARNDIRNVATRRIETEFEVRELEELPEEWRRSKLAWLCKEVPTHKAVTLVRLLNAQKKWVRQEDATYISVHCMRIRENETGFRVYRWMTQQNWYRFDFGLTTKLAEYLGKERKFTKCREVFDDVLNQGRVPSESTFHILVVAYLSSLSVEGCLEEACSVYNRMIQLGGYKPRLSLHNSLFRALVSKQGGILNDQLKQAEFIFHNVVTTGLEVQKDIYSGLIWLHSCQDEVDIGRINSLREEMKKAGFQESKEVVVSLLRAYAKEGGVEEVERTWLELLDLDCGIPSQAFVYKIEAYSKVGDFAKAMEIFREMEKHIGGATMSGYHKIIEVLCKVQQVELVETLMKEFEESGKKPLLPSFIEIAKMYFDLGLHEKLEMAFVQCLEKCQPSQPIYNIYLDSLTKIGNLEKAGDVFNEMKNNGTINVSARSCNSLLKGYLDCGKQVQAERIYDLMRMKKYEIEPPLMEKLDYILSLKKKEVKKRPFSMKLSKDQREVLVGLLLGGLQIESDKEKKSHMIKFEFRENSQAHLVLKQNIHDQFREWLHPLSNFQEDIIPFEFYSVPHSYFGFYAEHYWPKGQPEIPKLIHRWLSPHSLAYWYMYSGVKTSSGDIILRLKGSLEGVEKVVKALQAKSMECRVKKKGKVFWIGLQGTNSALFWKLIEPHVLENLKEHLKPASESLDNVKEAEEQSINFKSNSDHSDDCVNSEAHFY", "function": "Promotes the splicing of group II introns in chloroplasts. Required for the splicing of intron 2 of plastid ycf3 transcripts, a factor required for the assembly of photosystem I (PSI). Involved in the splicing of several other group-IIa introns. May be involved in the splicing of precursor forms of trnL, trnG, trnI, and trnA. Required for the assembly of PSI and PSII.", "AFDB_id": "AF-Q9XIL5-F1-model_v4" }, { "swissprot_id": "Q9H477", "sequence": "MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF", "function": "Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.", "AFDB_id": "AF-Q9H477-F1-model_v4" }, { "swissprot_id": "Q9H4Q4", "sequence": "MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLFEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEDQKKNKHEDFHPADSAAGPAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSTALQAHSPALPAPHAHAPALAAAAAAAAAAAAHHLPAMVL", "function": "Involved in the positive regulation of histone H3-K9 dimethylation.", "AFDB_id": "AF-Q9H4Q4-F1-model_v4" }, { "swissprot_id": "A8D8P8", "sequence": "MSEPRGRGRARGRAGRGGDGGGPAPRRPGEQAGPSQQSMPPGPRPQPPSGWGPQSSVPPVRAGVPTPTAQAGRASHRVTPTTHEHPGDIDVQQRMQKLELGPHSSGGGDASSVVGRGSRRGGGRVLPETISILRTRPEAVTSKKGTSGTPLDLLANYFTVETTPKWGLYQYHVDISPEEDSTGVRKALMRVHSKTLGGYLFDGTVLYTVNRLHPDPMELYSDRKTDNERMRILIKLTCEVSPGDYHYIQIFNIIIRKCFNLLKLQLMGRDYFDPEAKIDIPEFKLQIWPGYKTTINQYEDRLLLVTEIAHKVLRMDTVLQMLSEYAATKGNNYKKIFLEDVVGKIVMTDYNKRTYRVDDVAWNVSPKSTFKMRDENITYIEYYYKKYNLRIQDPGQPLLISRSKPREIRAGLPELIYLVPELCRQTGLSDEMRANFKLMRSLDVHTKIGPDKRIEKLNNFNRRFTSTPEVVEELATWSLKLSKELVKIKGRQLPPENIIQANNVKYPAGDTTEGWTRDMRSKHLLAIAQLNSWVVITPERQRRDTESFIDLIIKTGGGVGFRMRSPDLVVIRHDGPIEYANMCEEVIARKNPALILCVLARNYADRYEAIKKKCTVDRAVPTQVVCARNMSSKSAMSIATKVAIQINCKLGGSPWTVDIPLPSLMVVGYDVCHDTRSKEKSFGAFVATLDKQMTQYYSIVNAHTSGEELSSHMGFNIASAVKKFREKNGTYPARIFIYRDGVGDGQIPYVHSHEVAEIKKKLAEIYAGVEIKLAFIIVSKRINTRIFVQRGRSGENPRPGTVIDDVVTLPERYDFYLVSQNVREGTIAPTSYNVIEDTTGLNPDRIQRLTYKLTHLYFNCSSQVRVPSVCQYAHKLAFLAANSLHNQPHYSLNETLYFL", "function": "Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Recognizes piRNAs containing a phosphate at the 5'-end and a 2'-O-methylation modification at the 3'-end. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias) and a complementary adenosine in the target (t1A bias). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle: antisense piRNA-bound Siwi and sense piRNA-bound Ago3 reciprocally cleave complementary transcripts, to couple the amplification of piRNAs with the repression of transposable elements. In this process Siwi acts as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto Ago3. In this process, Siwi requires the RNA unwinding activity of the RNA helicase Vasa for the release of the cleavage products.", "AFDB_id": "AF-A8D8P8-F1-model_v4" }, { "swissprot_id": "Q554P0", "sequence": "MVELESMSSSSEWFLNNNSNIHNNTHNHNHNNNNNNNNINSNNHGHSANSSAHNHNNNNNNNTNNNSNNSNNNNNNNNNNNNTQNTNNGTFLTPLPVLTNSSTGLGKSIDWLYTNTSNTDSHNINSSSNKVTKLSNGFSLLNQDGTQSPSCFLNLSSTGNHEDPVQVPMNNNPQDLLFQFNISPQLQSQNNNSSNNNNNNNNNGSNTPLNGSNGSNNNYSSPISPVPQYQHSAGSSPIQEYPYYSPSSSPHSNESTSPITVIKDSGSIINPINNNNNNNNNNNNNNNNNNNNNNNNNNKNNLNNNTFQFSSLKSTTGIAPPLQTDYHLLYNFVQQNFSGKPEDSLLNQTLNNNNNNNNNNNNNNNNTTIQTSPQPLVLPQIQNPFLPYNISTPISVPNNILSSAQSSTNSSPNNNNNNNNNNNNIFSTVNNNNNLVNNNSNNMELDVDKPFSQEKFYLHLKSIVPSFNENFEASSESAQSESSQESDYDALNERNSGVKKRGRDEDQIDTSGQVVLSREHVLKLSSKEIEEYVSRLKMHHILTQAEEKELKKQRRLVKNREYASQSRSRRKIYVENIETKLQKTNQDCASIKSQLNSVKEENKALKKQLYSLTNTLKSNPSLAEAFGKIFSPIGNNKTSSATLFVFFFLFTFTFLFQSSTVTFNSDRVSSIQRNLLSLEETQATEWNIKRAILEETKQYVDSLLTSLYTSKLQSLSETPLDTSNYIINNNNNESTSETTTNNKVVSTSSDDISNVLSNLSVSDKEVPQKCKDSSDLKCDSPPLSPLN", "function": "Probable transcriptional regulator.", "AFDB_id": "AF-Q554P0-F1-model_v4" }, { "swissprot_id": "P0A3U4", "sequence": "MKSVILASIAAMFATSAMAADVVVSEPSAPTAAPVDTFSWTGGYIGINAGYAGGKFKHPFSSFDKEDNEQVSGSLDVTAGGFVGGVQAGYNWQLDNGVVLGAETDFQGSSVTGSISAGASGLEGKAETKVEWFGTVRARLGYTATERLMVYGTGGLAYGKVKSAFNLGDDASALHTWSDKTKAGWTLGAGAEYAINNNWTLKSEYLYTDLGKRNLVDVDNSFLESKVNFHTVRVGLNYKF", "function": "Major outer membrane protein associated with peptidoglycans. May function as a porin.", "AFDB_id": "AF-P0A3U4-F1-model_v4" }, { "swissprot_id": "Q9SPK4", "sequence": "MTCSQTLGNNNTNKYQICEEIGRGRFGTVSRVYAPATGDFFACKTIDKASLSDDLDRACLDNEPKLMALLSYHPNIVQIHDLIDTDSTLSIFMELVHPSVSIYDRLVSSGTFFEPQTASFAKQILQALSHCHRYGVVHRDIKPENILVDLRNDTVKICDFGSGIWLGEGETTEGVVGTPYYVAPEVLMGYSYGEKVDLWSAGVVLYTMLAGTPPFYGETAEEIFEAVLRGNLRFPTKIFRGVSSMAKDFLRKLICKDASRRFSAEQALRHPWIQRAGETEERFI", "function": "Calcium-independent kinase involved in light-dependent phosphoenolpyruvate carboxylase phosphorylation.", "AFDB_id": "AF-Q9SPK4-F1-model_v4" }, { "swissprot_id": "Q59QL0", "sequence": "MVSPSSPESNDDDDLTNADSAITPATSTITTDSPTKSSFDDYQSLSSIRIPITRRITPSLSPQYEESNISTTTSATTTTTQQQHQQQQLQQQQQQLRQMSSLSASKIEQAKTDVLNNKKISFIHRFITNWLIMDPNLISHYNNTNTRRFKNYQIENQGQSNFIYFLGGRLHTIKTKYPINLITLSLIIIPGILYIIFELSWQWRNFSPIIVIIFLYIWIISIFHFFKLSTCDAGKLPKNIHLPKKLITITTTTTTTNDNEIDHRNNYKVMGSPPDEYFNTVTLPYWKTNNDNNDNTKISKLANAYHSHGVQVKYCGTCHIWRPSRTSHCNTCQQCILNHDHHCIFLNNCIGQRNYKFFLWFLLYIVIACLYLLIISILQLCHYKFASHKESEIITTFNQSIKTHPISLLLLIYSCLAICYPGLLLAFHIFLTSQNITTREYLNFVYKKPSKSTDGGDGTRGFVNVYNTHSIWENLYINWLGKSNGVSLTFPRDYYHQGDIRFANIEPLGTFTNK", "function": "The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.", "AFDB_id": "AF-Q59QL0-F1-model_v4" }, { "swissprot_id": "Q0D9R7", "sequence": "MMKQAQQQPPPPPASSAATTTTAMAAAAAAAVVGSGCEGEKTKAPAINSELWHACAGPLVSLPPAGSLVVYFPQGHSEQVAASMQKDVDAHVPSYPNLPSKLICLLHNVTLHADPETDEVYAQMTLQPVTSYGKEALQLSELALKQARPQTEFFCKTLTASDTSTHGGFSVPRRAAEKIFPPLDFSMQPPAQELQARDLHDNVWTFRHIYRGQPKRHLLTTGWSLFVSGKRLFAGDSVIFVRDEKQQLLLGIRRANRQPTNISSSVLSSDSMHIGILAAAAHAAANNSPFTIFYNPRASPTEFVIPFAKYQKAVYGNQISLGMRFRMMFETEELGTRRYMGTITGISDLDPVRWKNSQWRNLQVGWDESAAGERRNRVSIWEIEPVAAPFFICPPPFFGAKRPRQLDDESSEMENLLKRAMPWLGEEICIKDPQTQNTIMPGLSLVQWMNMNMQQSSSFANTAMQSEYLRSLSNPNMQNLGAADLSRQLCLQNQLLQQNNIQFNTPKLSQQMQPVNELAKAGIPLNQLGVSTKPQEQIHDASNLQRQQPSMNHMLPLSQAQTNLGQAQVLVQNQMQQQHASSTQGQQPATSQPLLLPQQQQQQQQQQQQQQQQQQQQKLLQQQQQQLLLQQQQQLSKMPAQLSSLANQQFQLTDQQLQLQLLQKLQQQQQSLLSQPAVTLAQLPLIQEQQKLLLDMQQQLSNSQTLSQQQMMPQQSTKVPSQNTPLPLPVQQEPQQKLLQKQAMLADTSEAAVPPTTSVNVISTTGSPLMTTGATHSVLTEEIPSCSTSPSTANGNHLLQPILGRNKHCSMINTEKVPQSAAPMSVPSSLEAVTATPRMMKDSPKLNHNVKQSVVASKLANAGTGSQNYVNNPPPTDYLETASSATSVWLSQNDGLLHQNFPMSNFNQPQMFKDAPPDAEIHAANTSNNALFGINGDGPLGFPIGLGTDDFLSNGIDAAKYENHISTEIDNSYRIPKDAQQEISSSMVSQSFGASDMAFNSIDSTINDGGFLNRSSWPPAAPLKRMRTFTKVYKRGAVGRSIDMSQFSGYDELKHALARMFSIEGQLEERQRIGWKLVYKDHEDDILLLGDDPWEEFVGCVKCIRILSPQEVQQMSLEGCDLGNNIPPNQACSSSDGGNAWRARCDQNSGNPSNGSYEQFE", "function": "Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).", "AFDB_id": "AF-Q0D9R7-F1-model_v4" }, { "swissprot_id": "Q9HUB1", "sequence": "MYDWWVLQLAKLSVSRKLMVGFGVLLALLLLVVISSNRTLTHQTALSEQLAEVASLMEQTQQAEQGRLAFEAGSDPRQAEQVRQTLAGMLQRLQALRDSELDPAALAHQVEAIEAYRKAFDDLAAADQQRSAARGVLVGTAQQALDSFARLEELMDASLAQQAGDPQALQRSRAVADLHQQLLMVRYQVRGYVFERSDKAEQAAFAAFDALRQAATTLRGQLPGEADAALEQAMGSLQGYRGGIEQFRAGVIRTRQAQQAMQSSTQDMARAGRTLTEAGRQLRESTASRDRASLWLIAALALAFGCVAGWAINRQIVRPLDEALAQAEAIAAGDLGKRPQNPLTLQRRDELGQLQRVMQRMGDSLRELVGRISDGVSQLASSAEELSAVTEQTRAGVNSQKVETDQVATAMHEMAATVQDVARNAELASQAARQADEEARQGDAVVDQAVTRIERLASEMDVSSEAMARLKNESEQIGSVLDVIKSVAEQTNLLALNAAIEAARAGDAGRGFAVVADEVRGLAQRTQQSTAEIEGLIQRLQQGAGEAAERLENSRSLTASTVELARRAGAALDSITRTVSDIQNMNLQIATAAEQQSTVAEEINRSVLSVRDVAEQSAAASEQTAASSGELARLGTQLQAQVGRFRL", "function": "Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. McpK is a chemoreceptor that specifically binds and mediates chemotaxis to alpha-ketoglutarate (alphaKG).", "AFDB_id": "AF-Q9HUB1-F1-model_v4" }, { "swissprot_id": "Q869Q0", "sequence": "MVNKTSTNNNKEPRRMKKHYLKSNASNLKKTLHKIKVRGFEKLPVSVLSGFLGSGKTTLLNYILNSNHGLKIAVIVNDMSEVNIDSKLILENEFKITRTKATEKQVEAVVEMSNGCICCTMREDLLVEVTKLAKEKRFDYLIIESSGISEPLPIAETFTFEIDGSIENLKDYTKLDTMVTVVDCSTWLEQYQSGESLKDKDMQATDQDERSLVDLLLDQVEFSNVILLNKCDLVSEERVKTIEGLIKHINPEARLLRSTNSVVPLKEILNTGLFDFKKASEHPGWLKELRGTHVPETIEYGIKSFIYKARRPFNSERLSNVIEKGSAVFGGVLRSKGFSWIASTPELIGMWNLAGVQMTILNYGYWLADLKPHEYPNLDLQKEIKKNWSEPFGDRRQELVFIGGNTMNQSLIESELNNCLLTDAELLLGKDIWRTWIDPIQLDEELEEEELEEEEEEGEYKDEIEMKVDGSKFKK", "function": "Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Zinc is transferred from the CXCC motif in the GTPase domain to the zinc binding site in target proteins in a process requiring GTP hydrolysis.", "AFDB_id": "AF-Q869Q0-F1-model_v4" }, { "swissprot_id": "P86270", "sequence": "MQFSGVVLILISMTLVNFVFFETKVEAGKFGKCKPNICAKTCQTEKGKGMGYCNKTECVCSEW", "function": "Reversibly and voltage-independently blocks voltage-gated potassium channels rKv1.2/KCNA2 (73%) (IC(50)=196 nM), hKv1.3/KCNA3 (50%) (IC(50)=508 nM), Shaker IR (30%), rKv1.6/KCNA6 (22%) (at 0.5 uM). Interaction of Ts15 with Kv1.3/KCNA3 is stronger than its interaction with Kv1.2/KCNA2.", "AFDB_id": "AF-P86270-F1-model_v4" }, { "swissprot_id": "Q09822", "sequence": "MEVNGVSQSEAAPYVTKSSVKFRDNFWGSEDAGMDALMSRTKSSLSVLESIDEFYAKRASIEREYASKLQELAASSADIPEVGSTLNNILSMRTETGSMAKAHEEVSQQINTELRNKIREYIDQTEQQKVVAANAIEELYQKKTALEIDLSEKKDAYEYSCNKLNSYMRQTKKMTGRELDKYNLKIRQAALAVKKMDAEYRETNELLLTVTREWIDRWTEVCDAFQHIEEYRLEFLKTNMWAYANIISTACVKDDESCEKIRLTLENTNIDEDITQMIQNEGTGTTIPPLPEFNDYFKENGLNYDIDQLISKAPSYPYSSSRPSASASLASSPTRSAFRPKTSETVSSEVVSSPPTSPLHSPVKPVSNEQVEQVTEVELSIPVPSIQEAESQKPVLTGSSMRRPSVTSPTFEVAARPLTSMDVRSSHNAETEVQAIPAATDISPEVKEGKNSENAITKDNDDIILSSQLQPTATGSRSSRLSFSRHGHGSQTSLGSIKRKSIMERMGRPTSPFMGSSFSNMGSRSTSPTKEGFASNQHATGASVQSDELEDIDPRANVVLNVGPNMLSVGEAPVESTSKEEDKDVPDPIANAMAELSSSMRRRQSTSVDDEAPVSLSKTSSSTRLNGLGYHSRNTSIASDIDGVPKKSTLGAPPAAHTSAQMQRMSNSFASQTKQVFGEQRTENSARESLRHSRSNMSRSPSPMLSRRSSTLRPSFERSASSLSVRQSDVVSPAPSTRARGQSVSGQQRPSSSMSLYGEYNKSQPQLSMQRSVSPNPLGPNRRSSSVLQSQKSTSSNTSNRNNGGYSGSRPSSEMGHRYGSMSGRSMRQVSQRSTSRARSPEPTNRNSVQSKNVDPRATFTAEGEPILGYVIALYDYQAQIPEEISFQKGDTLMVLRTQEDGWWDGEIINVPNSKRGLFPSNFVQTV", "function": "After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.", "AFDB_id": "AF-Q09822-F1-model_v4" }, { "swissprot_id": "Q54R84", "sequence": "MTSTANYNNSGKDSYFSEIKKSELGLIKNNLSTAINERNADKIKDILQRIIYYMTIGMDVSVLFPDVIMVASSNDIIIKKLVYLYIVHYSKSNPDLLLLVVNTLRRDCIDRNPIIRGLALRSLCSLDSKNTLEYATIEINRSLTDFSGYVRKTALLGLAKLYHLSKEAFDLDIIIPKIFDMIMDQDPQVIVNAVSTLNEIKPGWSFTFDLVQHLMIKFKEFNEWSQCIILECLSRYTPSSEDESLDILNLLDDRLSHSNSALTLSTIKIFLKYTDEFEEIQEQVYERIKEPLITLMESSESNETSFTILHHIHLLMSRSPRLFNRYYKHFYCKFDDPLYIKTLKVQVLKEIASNQTFIESIDEILQELSEYVYEGDHSLCKQSINAITVIAQKHKNTQEKYPIDESVLEKIFLPYLSVSSNLGGAGDDNISINEGILSFILISLKDFLRVFPKHLKTVLPYINENLIGIGSVSNYTLPPSANESVLWMLGESPNSQVNSPYIIEEFFNEKFDQQPTFVKTQLLTTSLKVFFDRPGEMLPILKRILKKCCSDLSQDPGLHEISLFYSRIILLLDIDKAASIINSSKQTTSINTFLEDEINEYRDKIFDEFNTLSVLFGKHSTKFIKNKKQIENEKLQFLENQKNYLLSITDGNQNNNQNNNQNNNQNNNQNNNQNNQNNNNQNNNSKQLLKEIESSPNNLIDTFILDQQPELSPELFQSLWLSLEDGHKIDIQLDSPIDNSEIESVMSKQGIICLAFGSVDQQTKLYYYARQNLSFDIDFNSEQNQQQPQPIFIIEILIDENTLLMSILFKSPILKTLHNKFIPKFLSILSIPIPKIFN", "function": "Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways.", "AFDB_id": "AF-Q54R84-F1-model_v4" }, { "swissprot_id": "O74168", "sequence": "MRALPTTATTLLGVLFFPSASRSQYVRDLGTEQWTLSSATLNRTVPAQFPSQVHMDLLREGIIDEPYNDLNDFNLRWIADANWTYTSGKIEGLGEDYESTWLVFDGLDTFASISFCGQFVGATDNQFRQYMFDVSSILKACPEEPTLGIQFGSAPNIVDAIAQDPSSPTWPEGVQITYEYPNRWFMRKEQSDFGWDWGPAFAPAGPWKPGYVVQLKQAAPVYVRNTDLDIYRLGQINYLPPDQTQPWVVNASLDYLGSLPENPSMAIEVKDLQSGEILASRPLTNITVTEGSVTGVTVLEGVDPKLWWPQGLGDQNLYNVTISVTDGGNQSVAEVTKRTGFRTIFLNQRNITDAQLAQGIAPGANWHFEVNGHEFYAKGSNLIPPDCFWTRVTEDTMTRLFDAVVAGNQNMLRVWSSGAYLHDYIYDLADEKGILLCSEFQFSDALYPTDDAFLENVAAEVVYNVRRVNHHPSLALWAGGNEIESLMLLLVEAADPESYPFYVGEYEKMYISLFLPLVYENTRSISYSPSSTTEGYLDIDLSAPVPMAERYSNTTEGEYYGDTDHYNYDASIAFDYGTYPVGRFANEFGFHSMPSLQTWQQALTDPADLTFNSSVVMLRNHHYPAGGLMTDNYHNTVARHGRNDPGRAGLLPDAQHSVRPRGQLQRLVPRDPALPGGPLQVTNPVLPAGQRAARTPARVPVLAARGHLAGALVGGDRVRRPLEGPHYVARDIYKPVIVSPFWNYTTGALDIYVTSDLWTAAAGSVTLTWRDLSGKPIASNGGLPTKPLPFHVGALNSTRLYRMNMKQQPLPRHEDAILALELTATGSLPNTDEEVTFTHEQWFTPAFPKDLDLVNLRVRVEYDAPLGKFAVEATAGVALYTWLEHPEGVVGYFEENSFVVVPGQKKVVGFVVQADETDGEWVHDVTVRSLWDLNEGE", "function": "Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan. Releases the terminal mannose residue from mannotriose and is somewaht less active on other mannooligosaccharides.", "AFDB_id": "AF-O74168-F1-model_v4" }, { "swissprot_id": "P21846", "sequence": "MATTSQLPAYKQDFLKSAIDGGVLKFGSFELKSKRISPYFFNAGEFHTARLARRIASAFAKTIIEAQEKAGLEFDIVFGPAYKGIPLCSAITIKLGDVAPQNLDRVSYSFDRKEAKDHGEGGNIVGASLKGKRVLIVDDVITAGTAKRDAIEKITKEGRHRRGIVVALDRMEKLPAADGDDSKPGPSAIGELRKEYGIPIFAILTLDDIIDGMKGFATPEDIKNTEDYRAKYKATD", "function": "Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).", "AFDB_id": "AF-P21846-F1-model_v4" }, { "swissprot_id": "P03039", "sequence": "MNKLQREAVIRTALELLNDVGMEGLTTRRLAERLGVQQPALYWHFKNKRALLDALAEAMLTINHTHSTPRDDDDWRSFLKGNACSFRRALLAYRDGARIHAGTRPAAPQMEKADAQLRFLCDAGFSAGDATYALMAISYFTVGAVLEQQASEADAEERGEDQLTTSASTMPARLQSAMKIVYEGGPDAAFERGLALIIGGLEKMRLTTNDIEVLKNVDE", "function": "TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.", "AFDB_id": "AF-P03039-F1-model_v4" }, { "swissprot_id": "C7QJ42", "sequence": "MKNLSAYEVYESPKTSGESRTEAVSEAAFESDPEVSAILVLTSSEASTLERVADLVTAHALYAAHDFCAQAQLAAAELPSRVVARLQEFAWGDMNEGHLLIKGLPQVRSLPPTPTSNVHAVAATTPMSRYQALINECVGRMIAYEAEGHGHTFQDMVPSAMSAHSQTSLGSAVELELHTEQAFSPLRPDFVSLACLRGDPRALTYLFSARQLVATLTTQEIAMLREPMWTTTVDESFLAEGRTFLLGFERGPIPILSGADDDPFIVFDQDLMRGISAPAQELQQTVIRAYYAERVSHCLAPGEMLLIDNRRAVHGRSIFAPRFDGADRFLSRSFIVADGSRSRHARSSFGRVVSARFS", "function": "Alpha-ketoglutarate-dependent dioxygenase that in vitro catalyzes the regio- and stereoselective hydroxylation of L-lysine, leading to (3S)-3-hydroxy-L-lysine. Can also use (5R)-5-hydroxy-L-lysine as substrate, but neither D-lysine nor L-ornithine.", "AFDB_id": "AF-C7QJ42-F1-model_v4" }, { "swissprot_id": "Q81RQ7", "sequence": "MLIVNREEYSKSDFDLRLQAYEEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKKSSVLLIHEDTPKETAIEMAKRANCIGILYGENSDFTKLEAVNYLAEEPSLLQYSSGTTGEPKLIRRAWTEVDTEIKVYNEALNCDIDEVPIVMAPVSHSYGLICGTLSAITRGSKPIIITNKNPKFALNIVRNTEKHIVYAVPLMLHIMGSFPQGTFQFHKIMTSGAPLPEALFYKLKETTTYMMQQYGCSEAGCISICHDMKSHLDLGNPLPHASISIGSDENAPEEIIVKMNDKEIFTKDLGYKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKVISHIDPVQIREWCMQHLPSYKVPHEIESVTEIPKNKTGKVSRKLLEMGEVTT", "function": "Involved in the biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence. Catalyzes the adenylation of 3,4-dihydroxybenzoate (3,4-DHBA) to the corresponding AMP ester, followed by the transfer of the activated unit to the phosphopantetheine thiol of the aryl-carrier protein AsbD.", "AFDB_id": "AF-Q81RQ7-F1-model_v4" }, { "swissprot_id": "Q54CE0", "sequence": "MSYNSSNSGSGRYDDNRSGNSSYSSTSRGGSSYGNRSGSDRDYNRDGGSYNRDSSRDYNSSSGSGSGNGSSSYNKYPSSSSSSSSSSSTSSYGPSKGKDFQDSWGSSSTGTTNGYNGSSNGYNSSSNGYNSSNSSSSYGASNNGYNNSSGSSSSGSSGSSNGGSYNNSGSSNSNGYSKPTSNYSYSNGYTGPTTNYSSYSNGYSTPPTSTSTSSSSTTTTTTTTPSTSYNGGSTSYGYSTSGSSNGYGGYSQPPIPSYDPSSVSSYGAVTPASSSYNASVPGSSYGNSTYRSSGYGNQSYATTNSYGSSSYGSSGFYGNAKANTGSFGSALSPISWDLSKLPRFEKNFYLEHPDVSKFTQEEIEKFRASFQMTVKGREVPPPIMQFTQAPFPGYLMKEIIGAGFPNPTPIQSQAWPIALKGRDIIGLAKTGSGKTLAFLLPSIVHINAQPVLREDDGPIVLVLAPTRELALQIQEETNKFGGTSQISNTCVYGGASKHTQVAALKKGVEIVIATPGRLIDILESGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIISQIRPDRQTLMFSATWPKEVQALAHDFLTDHIQVHIGSTEITANHNVRQIVEVCQDFEKKERMLSFLGSVGRDEKVIVFAETRKGVDDLQRVLQFSGFKSIGIHGNKSQPERDFVLSQFKNGMVPIMIATDVASRGLDIKDIKYVVNYDFPNTIEVYIHRIGRTARAGASGVSYSLLTTDNARLANELIKVLTEAKQKIPIELSNLSVTPSTSSNTKKFSPYPTYSKRY", "function": "Probable ATP-dependent RNA helicase which may be involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.", "AFDB_id": "AF-Q54CE0-F1-model_v4" }, { "swissprot_id": "P09928", "sequence": "MATRGWFSESSAQVAQIGDIMFQGHWQWVSNALQATAAAVDNINRNAYPGVSRSGSGEGAFSSSPSNGFRPKRIRSRFNR", "function": "Component of the photosynthetic apparatus. The light harvesting B740 complex binds bacteriochlorophyll c.", "AFDB_id": "AF-P09928-F1-model_v4" }, { "swissprot_id": "C5A3H4", "sequence": "MARKKGVKALLLNWRVLLLILFLIGSVVSMSIKGLTYGIDIGGGVALIAEPEKPVSKDTLNGIITSLQNRLNTFGVKDITIEAQHDPETGQSLIVVKIANVTLDEANQIKDLIESQGVLYMEFNGVIFATGTDVTVHSSDYGLDLQECPTCWYVGFELSGKAQNKFKKIAAGKLGWPIDIYLDPPVNSLLVVSPRVYQEMNSGDFMGAPSEGTPKPLVERLKEAFNITVVEYSNQTAEDIVENATALGKDKIILADVPEELYNDVRELVLSKDLKLRVSHYTPQQGEDLKDFVKRILNLYGPYVLKFDPAKGETTRLKLSGSAPTKEEALQEARKIYSVLRSGSLAVKLHVVSEEYISPTLGASFKKQAIIAGIGALIAVLLIVYFHYRRWRIAIPVASTSLFEVIIILGIAALIRWNLDLPSIAGIIAAIGTGVDQQIVITDELLGGTAGRVTRRMSALRRMARAFFIIFASAATTIVAMSFLLVYFVGTLKGFAVTTILGVLIGVLVTRPAYAEIAKYLLSLE", "function": "Involved in protein export.", "AFDB_id": "AF-C5A3H4-F1-model_v4" }, { "swissprot_id": "P94248", "sequence": "MTMIFPKGFMFGTATAAYQIEGAVAEGGRTPSIWDTFSHTGHTLNGDTGDVADDFYHRWEDDLKLLRDLGVNAYRFSIGIPRVIPTPDGKPNQEGLDFYSRIVDRLLEYGIAPIVTLYHWDLPQYMASGDGREGGWLERETAYRIADYAGIVAKCLGDRVHTYTTLNEPWCSAHLSYGGTEHAPGLGAGPLAFRAAHHLNLAHGLMCEAVRAEAGAKPGLSVTLNLQICRGDADAVHRVDLIGNRVFLDPMLRGRYPDELFSITKGICDWGFVCDGDLDLIHQPIDVLGLNYYSTNLVKMSDRPQFPQSTEASTAPGASDVDWLPTAGPHTEMGWNIDPDALYETLVRLNDNYPGMPLVVTENGMACPDKVEVGTDGVKMVHDNDRIDYLRRHLEAVYRAIEEGTDVRGYFAWSLMDNFEWAFGYSKRFGLTYVDYESQERVKKDSFDWYRRFIADHSAR", "function": "Bifunctional beta-D-glucosidase/beta-D-fucosidase. Activity towards pNP-beta-D-fucoside is about 80-85% of the activity towards pNP-beta-D-glucoside. Also has slight activity (less than 10%) towards pNP-beta-D-galactoside, and very low activity (less than 1%) towards pNP-beta-D-xyloside. Hydrolyzes laminaribiose, sophorose, cellobiose and gentobiose. Not active against maltose, pNP-alpha-D-glucoside or pNP-beta-L-fucoside.", "AFDB_id": "AF-P94248-F1-model_v4" }, { "swissprot_id": "Q6P2D8", "sequence": "MAFSGIYKLDDGKPYLNNCFPARNLLRVPEEGQGHWLVVQKGNLKKKPKGLVGAQAERRESLKATSFEFKGKKESRRENQVDLPGHILDQAFLLKHHCVRKPSDLCTINAKENDFKHFHSVIYINASENLLPLEAFHTFPALKELDLAFNGIKTIYVKYGDFKLLEFLDLSFNSLTVEAICDLGILPHLRVLLLTGNGLTSLPPNLAVAEQEASVTSLTSKRYILRFPALETLMLDDNRLSNPSCFASLAGLRRLKKLSLDENRIIRIPYLQQVQLYDESVDWNGGRGSPHKEPQFMLQSKPRMLEDSDEQLDYTVLPMKKDVDRTEVVFSSYPGFSTSETTKICSLPPIFEILPVKSLKARNQTLAPPFPELRYLSLAYNKIAKEDAVLPVALFPSLCEFVFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKPKHHVLMSRKESWKVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHKQYLEAKRLLKEFQARYRQLVSGSLRTVFGTTPLPMACPALSESQPKFGHFLEFMDEFCQEPTASDSQG", "function": "May be involved in the response of cells to X-ray radiation.", "AFDB_id": "AF-Q6P2D8-F1-model_v4" }, { "swissprot_id": "Q92PW7", "sequence": "MHADPGIEVSLAKGFFITFEGGEGTGKSTQMRLLAEALSARGYRVLTTREPGGSVGAEAVRHVLLSGAAESFGVRMEAILFAAARSDHVEEVIRPALEQGTIVLCDRFMDSSRVYQGVTGNLEPAFVETLERVAVNGVIPDCTIIFDLPASVGLERARRRAANDSPDRFEKEQLETHEKRREAFLDIAAADPERCRVVDANRPPTAIAAEVLSLVEALLPLEGKPQPSNAEATS", "function": "Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.", "AFDB_id": "AF-Q92PW7-F1-model_v4" }, { "swissprot_id": "O60548", "sequence": "MTLGSCCCEIMSSESSPAALSEADADIDVVGGGSGGGELPARSGPRAPRDVLPHGHEPPAEEAEADLAEDEEESGGCSDGEPRALASRGAAAAAGSPGPGAAAARGAAGPGPGPPSGGAATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYGAPPPGPAPHPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSAPAPAPASGSGPGPGPAGLPAFLGAELGCAKAFYAASLSPPAAGTAAGLPTALLRQGLKTDAGGGAGGGGAGAGQRPSFSIDHIMGHGGGGAAPPGAGEGSPGPPFAAAAGPGGQAQVLAMLTAPALAPVAGHIRLSHPGDALLSSGSRFASKVAGLSGCHF", "function": "Probable transcription factor involved in embryogenesis and somatogenesis.", "AFDB_id": "AF-O60548-F1-model_v4" }, { "swissprot_id": "Q6STH5", "sequence": "MPLLHPQSLRHPSFEIQTQRRSNSTTRLLLSHKFLHSQASIISISRTRILKRVSQNLSVAKAASAQASSSVGESVAQTSEKDVLKALSQIIDPDFGTDIVSCGFVKDLGINEALGEVSFRLELTTPACPVKDMFENKANEVVAALPWVKKVNVTMSAQPAKPIFAGQLPFGLSRISNIIAVSSCKGGVGKSTVAVNLAYTLAGMGARVGIFDADVYGPSLPTMVNPESRILEMNPEKKTIIPTEYMGVKLVSFGFAGQGRAIMRGPMVSGVINQLLTTTEWGELDYLVIDMPPGTGDIQLTLCQVAPLTAAVIVTTPQKLAFIDVAKGVRMFSKLKVPCVAVVENMCHFDADGKRYYPFGKGSGSEVVKQFGIPHLFDLPIRPTLSASGDSGTPEVVSDPLSDVARTFQDLGVCVVQQCAKIRQQVSTAVTYDKYLKAIRVKVPNSDEEFLLHPATVRRNDRSAQSVDEWTGEQKVLYGDVAEDIEPEDIRPMGNYAVSITWPDGFSQIAPYDQLEEIERLVDVPPLSPVEV", "function": "Required for photosystem I (PSI) biosynthesis and assembly. May serve as a chloroplast scaffold protein that specifically assembles iron-sulfur (4Fe-4S) clusters and transfers them to the chloroplast PSI and ferredoxin-thioredoxin (FTR) complexes. Can assemble a 4Fe-4S cluster and transfer it to apoproteins in yeast cells. Probably not required for assembly or stability of plastidic 2Fe-2S clusters.", "AFDB_id": "AF-Q6STH5-F1-model_v4" }, { "swissprot_id": "Q8K0T0", "sequence": "MAAPPDLQDEPLSLGSPGSQWFGGRGDGEDEATAVMGARPAQQDGEPAWGSGAGAGVTSSRELCSGPARSPPVAMETASTGMAAVPDALDHSPSSTLKDGEGACYTSLISDVCYPPREDSAYFTGILQKENGHITTSESPEEPETPGPSLPEVPGMEPQGLLSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPQEAKGQEEQHPGLEDKDLDFKDKDTEVSTKAEGVRAPNQPAPVEGKLIKDHLFEESTFAPYIDELSDEQHRVSLVTAPVKITLTEIEPPLMTATQETIPEKQDLCLKPSPDTVPTVTVSEPEDDSPGSVTPPSSGTEPSAAESQGKGSVSEDELIAAIKEAKGLSYETTESPRPVGQVADKPKTKTRSGLPTIPSPLDQEASSAESGDSEIELVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPGALDAIREETGSRATEERAPSHQGPVEPDPMLSFAPAAALQSRPEPSSGDGASVPEPPRSQQQKPEEEAVSSSQSPTATEIPGPLGSGLMPPLPFFNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQYLGLVRTHINTVVAKIQAKIPGAKRHAE", "function": "Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.", "AFDB_id": "AF-Q8K0T0-F1-model_v4" }, { "swissprot_id": "A9KP81", "sequence": "MLGIDHNKASIEEREIFSFTKKMAADVLLNIKEIEGINGCIILSTCNRMEVWVSCFEEFETSIYEILCSIKKVDDNRYRHCFIERGGYDAIEHLFYMTCGLKSKIIGEDQILTQVREALELSRENYCTDSVLETLFRFAITSAKQVKTQIHLSVVNSSVIHHVVHELKLSNYLFKGKKCLVIGNGEMGKLAATKLEEEGSDVTVTVRQYRSGIIEIPVGCNRINYGDRLEHIVEYDFVISATSSPNMTIHLEQLSNLEFKKPVLFIDLAVPRDIDPRITELKNITLYDIDHFKVETVSDEMKTQLRQIDEILKTKMDEFISWYECRGIIKVVQTLSENAAIDVGLRIDKTMKKIEMDSNDKELLAATVHSATNKVVSKLMFGLRDHVSAATFQECMVALKNIY", "function": "Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).", "AFDB_id": "AF-A9KP81-F1-model_v4" }, { "swissprot_id": "Q7M3M8", "sequence": "MSNQMEFIMQLYMMNLMKQQQQMQLQLPQQQQQQQLAGYTYTQNEDISSSTSVQQQQQQQQEQLQQPQPDLRKTRTHKRISSQNTNCSSSRSCSPNSNLIAFQPQQYPGATAATPSTPNSHPSNLVNQMLLQSLPPLTQLMLQQQQQQHLLTTSNLLLTPTHTPSSLGKQDPLQHPLLLGQFAGSEQMATNNFLQSSTVTSTPIEREKAATPAPSAGATAGNLSAAQVKFEQESADDDEDDDKPLSSLTSCSSSGHTNASSEKLLLSGVHPLESTTDSLDSPSMYTPVKQPADSSYGLITPVDSDLTPNTPLQPTQTISLLTPPSSEQSKSLVSLSAASGLDALLQNEEVLKNLRKVSSYLECENSLCRQENLREHFHCHEEPCQGKILSKKDDIIRHLKWHKKRKESLKLGFARFSSSDDCAPAYGEGCAYNWKQTHYHCVYEHCPKVYVSTSDVQMHANFHRKDSEIVNEGFRRFRAHETCRIEDCPFFGKKISHYHCCREGCTHTFKNKADMDKHKTYHLKDHQLKMDGFKKILKTEVCPFDACKFSTVCNHIHCVREGCDYILHSSSQMISHKRKHDRQDGEQAYQQFKIKQDVEESSLDAMPQQQQQQQQQQPTSLSQSQSSSSVCGGSNTSTPLSSLSAEHFLARKRGRPPKKIQLPADAQQSEAKRLKVEDESSNPAMLLPQSQPAAAVHPLTSGLFPGLLPAAAAPGVDPTAPNFQLTHLMALFQLQNPLFYQNLYPGMTQNSSMLGNLAALSAASAAAAAAAAANGAGVQQPKAEFSFKPEFKE", "function": "Transcription factor that specifies expression of key genes in developing central nervous system (CNS). Essential for many, if not all, late developing neuroblastoma (NB) sublineages. Binds to the 5'-[CG]C[CT][CT]AAAAA[AT]-3' DNA sequence, like hb, suggesting that cas and hb act as a late regulators in early and late CNS NB sublineage, respectively. Acts by repressing expression of nub/pdm-1 and pdm2/pdm-2 POU genes, and restrict their pattern of expression in appropriate cells. Required for a full expression of vvl/drifter and acj6/I-POU; it is however unknown whether it directly activates these genes. Controls engrailed (en) expression in the ventral nerve chord.", "AFDB_id": "AF-Q7M3M8-F1-model_v4" }, { "swissprot_id": "Q1JQ92", "sequence": "MVRFKHRYLLCEVVSDDPRCRLTLEDRVLGTLVRDTIARVHGTFGAAACSIGFAVRYLNAYTGIVLLRCRKEFYRLVWSALPFITSLENKGHRYPCFLNTLHVGGTIRTCQKFLIQYNRRQLLILLQNCTDEGEREAIQKSVTKSCLLEEESAGEELSDSGGEETAEPME", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.", "AFDB_id": "AF-Q1JQ92-F1-model_v4" }, { "swissprot_id": "Q17217", "sequence": "MSSNVIVLCVSALFIQCAVSQCVGRIGSLRGGPFDGWGYDGLGYDGFGIGGWNGRGCGGLGDDIAAAAALGASHGGTLAVVSTSAAPTGLGIASENVYEGSVGVCGNLPFLGTADVAGEFPTAGLGGIDYTCGDGAVGITVENAINGISNVGYGLAPGIVGPAVAAPALGYGPGISSLGYNTAGRGCGCGANYY", "function": "This protein is one of many from the eggshell of the silk moth.", "AFDB_id": "AF-Q17217-F1-model_v4" }, { "swissprot_id": "P53784", "sequence": "MYSLLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAGNGGSGGANGGGGGGGGGGSDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPGGLLPPGAAAAAAAAAAAAAASSPVGVGQRLDTYTHVNGWANGAYSLVQEQLGYAQPPSMSSPPPPPALPQMHRYDMAGLQYSPMMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIASHSQRACLGDLRDMISMYLPPGGDAADAASPLPGGRLHGVHQHYQGAGTAVNGTVPLTHI", "function": "Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.", "AFDB_id": "AF-P53784-F1-model_v4" }, { "swissprot_id": "P38863", "sequence": "MEIKEVDDRAELLRYTNNIPLLGKLVNHQPLWSTNPKLKSFSLEKISAPDQRRVQEALVVKDLLNVLIGLEGTYIRYFNDYEPSDPETPIEFKIAKKMDPSFKTFSRRIVRYGKQYMILTRAYEKWSDTSFGMVLQRFAYEIRRFLEDVYLKTLVERLERDFNKVPNFSIRELEQIINETEVNKQMELLYNIYEEIFREIEERRTNQSSQEDFNNFMDSMKNESSLHLRLMVAFDTTVYPVPKGGAILKIFQQKILENLGDRSSVMFLKKLLNNISQDYCTMLYEWLTQGILNDPYQEFMTYDDLEGKTDNIFDTRDRAWDTQYFIRKDVLLRDCDSEEDKNLLFKMLRTGILLKVVRASLQIPTIPSNSSDITIQEINDFADLMEGSNLELYVDKCYSRANEIFLKLFFQGYDLINVLKHLQQIFLGYQSGHNVLKFLTKNMGELTKHYRNDNNANYDKLLQNFELERQSENPNNLMRQLLMIQFDTETLPQVLSHYLQIYPEVPENNSANDDSDPLMHANNFKNMNAILFDELSKERTGAYHGSNLELYTPKSAIYHLKFDINIPYPLNIIISRTCMIKYQIILRYQLVLQYHSRLLDETWMDLNKTPSWKYRGYSHTVKRRIVRATRVLHAKMNHFIKTIMEYFNQNVIDKEVYSLEKCYRNPTLAVAIQNELEGGLTNIMTNRCLSDLIPLQLQIFDIVYKFCKFIKSMRAKLCQLDPVLYEKHKSGMMKTLNEGYRTNNGGQEDVGYQEDAALELIQKLIEYISNASSIFRKCLINFTQELSTEKFDFYDSSSVDAAGIERVLYSIVPPRSASASSQR", "function": "Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB.", "AFDB_id": "AF-P38863-F1-model_v4" }, { "swissprot_id": "Q9VS78", "sequence": "MILTATFICFCLASAFNYFRARRQRSLIKNLKGPFTWPLMGAMHKLLFLTPINFFQRSTEYLTKYGTFSRCWVFHRLFIPLADLELSRQLLENDTHLETGYELMKDWLVGGVLMCQSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQADQKVFDIWYTVSPIVLDLMVMTTCGAKPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSLLEILLESKDPQLTGEEICGELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDELNLAQIKDQGWDLEKLNYLDAVLHETMRLYPPQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLDSPPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLRLVLGSSNGFQLALKPR", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9VS78-F1-model_v4" }, { "swissprot_id": "P37963", "sequence": "MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYVSIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKVSHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEELSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESVASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAEPAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYALRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNADLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIEVRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYLTKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILYIPQYKNSHA", "function": "Required for assembly of a normal spore coat. May be a component of the innermost layer of the spore coat that aids in its adherence to the prespore.", "AFDB_id": "AF-P37963-F1-model_v4" }, { "swissprot_id": "G0GBS4", "sequence": "MEPVDRMRELLSFIYGPETGRDTHEALHALLDGWRGRLPSPDEEYASGRLPLDHTDAVLITYGDQFGRKGEAPLATLGEFLREYLSGTMKGVHILPFFPYSSDDGFSVMDYRRVNPEWGTWDDVRRISEDFRLMVDLVLNHCSAKSEWFRRFLQGDPEYEDFFITVEPGTDLSGVFRPRALPLVHEFESAKGPVLVWTTFSRDQVDLNYANPRVLLEMIDIFLFYVSQGAQIIRLDAIAYLWKELGTPCIHHPKTHAVVKLFRAICEEVCPWVLIITETNVPHKENISYFGDMDEAHLVYQFALPPLVLDAFLRKDVSYLREWARTIDTYGGKVSYFNFLASHDGIGVLPARGILPDEYIDAMIEAVKDRGGLISYKSTPQGEVPYELNINYLSAISESHLDRPTRARKFLASQAVMLSLVGMPGIYVHSLLGSENWREGVEKTGMNRTINRQKLSYEGVLEELRDPESLRSMVFEGYLDMLAARRKSRAFDPRGMQEVLEAPETVFALLRRSPDATEEVLCLINVSHIEQECVFPSSIFRTAPDAHLFTELTSGDTLVPYREDEDRFSISLGGYEVLWLTPYRDKG", "function": "Catalyzes the reversible phosphorolysis of glucosylglycerate into alpha-D-glucose 1-phosphate (Glc1P) and D-glycerate. May be a regulator of intracellular levels of glucosylglycerate, a compatible solute that primarily protects organisms facing salt stress and very specific nutritional constraints. Cannot catalyze the phosphorolysis of sucrose.", "AFDB_id": "AF-G0GBS4-F1-model_v4" }, { "swissprot_id": "Q38847", "sequence": "MGRGKIEIKRIENANSRQVTFSKRRSGLLKKARELSVLCDAEVAVIVFSKSGKLFEYSSTGMKQTLSRYGNHQSSSASKAEEDCAEVDILKDQLSKLQEKHLQLQGKGLNPLTFKELQSLEQQLYHALITVRERKERLLTNQLEESRLKEQRAELENETLRRQVQELRSFLPSFTHYVPSYIKCFAIDPKNALINHDSKCSLQNTDSDTTLQLGLPGEAHDRRTNEGERESPSSDSVTTNTSSETAERGDQSSLANSPPEAKRQRFSV", "function": "Transcription factor involved in the negative regulation of flowering, probably through the photoperiodic pathway. Acts as both an activator and a repressor of transcription. Binds DNA in a sequence-specific manner in large CArG motif 5'-CC (A/T)8 GG-3'. Participates probably in the regulation of programs active during the early stages of embryo development. Prevents premature perianth senescence and abscission, fruits development and seed desiccation. Stimulates the expression of at least DTA4, LEC2, FUS3, ABI3, AT4G38680/CSP2 and GRP2B/CSP4. Can enhance somatic embryo development in vitro.", "AFDB_id": "AF-Q38847-F1-model_v4" }, { "swissprot_id": "P81831", "sequence": "MQLSATSGRTSFRVSQDLRTGPANFLSGLRDDDSLLRQVFFSILRHHHPNLAAKVDVIYALSQAWCTSQSDNDFELMVKYVSDLKPEERILVASSFSHMLNLHNLTEEVNSSQIGRAVRLGEMDSPTRDTNHSLLKLTTTNGFTPQQVYDTLCSQTVELVLTAHPTQALRASLLKKYAIVRRELDTLHSKRMSEYEKIETLEAIRAAVQAAWRTDEIRRSKPTPQDEMRSGLSYFSTVIFDVVPVFHRRVDTALEKLGLPRLPLDRALFKFGSWMGGDRDGNPNVTAETTRDVVVLARLEAVNVYFRQVEGLMFDLSIWRCSPEMKELAERLAAAESRDAARVAEERKRRNYVDFWAPIPPTEPFRVVLAHMRDRLYNTRQVLHQCLIHTHMSVRGALEEAGAYVDIEDMARPLKLMYDSLMSTGDESVANARLLDLLRQIRTFGLCMMGLDVRQESTRHTEVMDAVTTYLGLGSYASWDEPKRLAFLLGELQGKRPLMPPGMDMSPEVKEVVRTLRILSELPGDSLGAYIISMAKTASDVLAVVLLQRETGVRPALRVVPLFETLDDLHNAPGTMTTLLGNDWYRGHINGVQECMIGYSDSGKDAGRLAAAWALYETQEKLVEVAAGCGVRLVLFHGRGGTVGRGGGPTHMAIRSQPSGTINGHLRVTVQGEIIEQQFGEKEVCFRTLDLYTSAVLEAALDPPPAPAQEWRDLMSLLATESCDMYRSVVYRTPEFYDYFMQSTAASELGRLNIGSRPSSRKSGGIETLRAIPWIFAWTQQRLHLPVWLGIGEALEAAIDKGYGPVLQDMYANWPFFTSTLDLVEMVLAKADSRLSAFYERTLVDSSLAPLGQRLRELLAKTQQNILIVVRKSVLLEGNTPSQMSTPNLDEKIRLRSPYVAPLNVLQALSLQGLRKFRDGGDTEYNPSDPEIIDLLSRDPHKKGEGAQHPFVSAMDDCLMITIKGIAAGMQNTG", "function": "Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.", "AFDB_id": "AF-P81831-F1-model_v4" }, { "swissprot_id": "S3D775", "sequence": "MIAALFTTNLQLGAVGVFIFALLAFAFNKLTTWEYSIPKEVQWVDRRTQPFSYLRAKARALARSKENTLEAYFRFNKLGKAAALAVPFGRPLLLLPQTFVRWIVDQPESIISLDPIHDDFHVFVGGDLTGDHTVQELLRRELTLNLDKLISVINDEIVCALDDVLGNSPEWKSTSLADDLKTIVARTSNRVFVGKDLCRNKHYISTVKGLALVIMPETVLQDLIPQFLKGPLSRITKAFNNIYGMKKFSSLLLGVVRQRYIDVKDVLEGSGDKTRLPDDLLTWMVQKSIRKGESSANIDKLLVARIAMANLAAIETTTAAMTRSVLDLVTQGSEGGFLKAVQEETLAVVEGCNYEPSKKDVLKLVLTENAIKEALRLQVAFPGLMRQVVAPNGVTLENGLHVPCGTRLGVSAAGIHVDESIYEDPTTYNPGRFLVRDLDPRGDPSPMWKGNENYLAFSLGRRSCPGRWYVTDQLKLTLAHIFSKYEIRFEKAAETASALRKILPGAPQDRVMIRRRSVGKR", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase. The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4. The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain. The 10R,12S-dimethylmyristic acid is then transferred to the first thiolation domain of the nonribosomal peptide synthetase gloA/GLNRPS4 by the acyl-AMP ligase gloD/GLligase, followed by its acylation to L-ornithine to trigger elongation of the cyclic hexapeptide. L-ornithine, 4R-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2), 3S-hydroxyl-L-homotyrosine (generated by gloG/GLHtyB, gloH/GLHtyA, gloI/GLHtyC, gloJ/GLHtyD and hydroxylated at C-3 by the dioxygenase gloM/GLOXY1), 3R-hydroxyl-L-glutamine (generated from L-glutamine probably by the dioxygenase gloE/GLOXY3) and 3S-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2 to yield pneumocandin B0), or 3S-hydroxyl-4S-methyl-L-proline (generated from L-leucine by the dioxygenase gloC/GLOXY4 to yield pneumocandin A0) are sequentially added to the growing chain. The last C domain of gloA/GLNRPS4 is proposed to be responsible for cyclization by condensation to form the peptide bond between L-ornithine and 3S-hydroxyl-4S-methyl-L-proline (for pneumocandin A0) or 3S-hydroxyl-L-proline (for pneumocandin B0). Finally, the subsequent C-4 hydroxylation of 3S-hydroxyl-L-homotyrosine and L-ornithine dihydroxylation at C-4 and C-5 are performed by the cytochrome P450 monooxygenases gloP/GLP450-1 and gloO/GLP450-2, respectively.", "AFDB_id": "AF-S3D775-F1-model_v4" }, { "swissprot_id": "P23900", "sequence": "MSNPQKALNDFLSSESVHTHDSSRKQSNKQSSDEGRSSSQPSHHHSGGTNNNNNNNNNNNNSNNNNNGNDGGNDDDYDYEMQDYRPSPQSARPTPTYVPQYSVESGTAFPIQEVIPSAYINTQDINHKDNGPPSASSNRAFRPRGQTTVSANVLNIEDFYKNADDAHTIPESHLSRRRSRSRATSNAGHSANTGATNGRTTGAQTNMESNESPRNVPIMVKPKTLYQNPQTPTVLPSTYHPINKWSSVKNTYLKEFLAEFMGTMVMIIFGSAVVCQVNVAGKIQQDNFNVALDNLNVTGSSAETIDAMKSLTSLVSSVAGGTFDDVALGWAAAVVMGYFCAGGSAISGAHLNPSITLANLVYRGFPLKKVPYYFAGQLIGAFTGALILFIWYKRVLQEAYSDWWMNESVAGMFCVFPKPYLSSGRQFFSEFLCGAMLQAGTFALTDPYTCLSSDVFPLMMFILIFIINASMAYQTGTAMNLARDLGPRLALYAVGFDHKMLWVHHHHFFWVPMVGPFIGALMGGLVYDVCIYQGHESPVNWSLPVYKEMIMRAWFRRPGWKKRNRARRTSDLSDFSYNNDDDEEFGERMALQKTKTKSSISDNENEAGEKKVQFKSVQRGKRTFGGIPTILEEEDSIETASLGATTTDSIGLSDTSSEDSHYGNAKKVT", "function": "Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions.", "AFDB_id": "AF-P23900-F1-model_v4" }, { "swissprot_id": "P37671", "sequence": "MGKEVMGKKENEMAQEKERPAGSQSLFRGLMLIEILSNYPNGCPLAHLSELAGLNKSTVHRLLQGLQSCGYVTTAPAAGSYRLTTKFIAVGQKALSSLNIIHIAAPHLEALNIATGETINFSSREDDHAILIYKLEPTTGMLRTRAYIGQHMPLYCSAMGKIYMAFGHPDYVKSYWESHQHEIQPLTRNTITELPAMFDELAHIRESGAAMDREENELGVSCIAVPVFDIHGRVPYAVSISLSTSRLKQVGEKNLLKPLRETAQAISNELGFTVRDDLGAIT", "function": "Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L-gulonate.", "AFDB_id": "AF-P37671-F1-model_v4" }, { "swissprot_id": "P31706", "sequence": "MRSRQRGAALLVVLLILALMVTIAAVITERTGKAFLRTESHLSRQQAKWYALGAETLSGQILQRDARNMPGRTFAGQNWSQPGLRFPVDGGEITGQISDARTCFNVNAINQGVDNESTLVKTPYPAQVFRLLLKNLGEETDRAEKITAAVRDWIDADNYPSANGAEDDVYAALPVPYRTANQRMSEISELRSVYGIDSDLYRRLLPYVCALPVDAMSININTLTEFDAPLLSAVFLNEMTMSQAKALVQQRPRMGWASLEVLQQTGLLPPNSKNTAQRVLAVKSEWFFVKLQVRVGDSDFHQRSLLHLSGQKVQVVQRQYGGYRTVNP", "function": "Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Plays a role in pseudopilus assembly and seems to control its length. Interacts with the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.", "AFDB_id": "AF-P31706-F1-model_v4" }, { "swissprot_id": "Q3Z6R8", "sequence": "MPPFRAVILFRHMEINVIVKPPFKKLVSTPFLKKIASKTLKAQAADPNSELGIVITGQEEIKDLNLKYRGLDEPTDVLSFYMLEENPENLTAADDFPTPPDENIHLGEVIISYPQAELQATAASHSVSHEIAFLLIHGVLHLLGYDHHEVVAEAVMKSHQDIAMKHIREILE", "function": "Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.", "AFDB_id": "AF-Q3Z6R8-F1-model_v4" }, { "swissprot_id": "Q87P32", "sequence": "MISFGNVSALQAAMPQARNEILNEGKLSIGGKEYTINAATQEFTRANPTSGAVARFFEATGKLFREGSTQSVAKAITKAVFDNEQGQAQRLQTSSSVEHGQMLFKDANLKTPSDVLNAFAKLDSKMVKSHAAELSQLAERAMTEVMLETDSGKNLKALIGDDAVKSLAVRVVKDYGGGVAAAQKNPEVRINQMQAVFDMEVMHLKAAQRHIEGLASTDLNQGVYAEGLPEDAFNKAGVTNNVERAAAWIINASNSKGNDAENITSLLKEYATNGKDLLNMDNLKELHARLVPNVERDYRGPNISGGTLPSSIGGEGMLKQHIEGFLKENPVADKDLGKHLFAGVIGYHGFTDGNGRMGRMLYAIAELRNDSFNPLAMNAENSLHGIK", "function": "Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific threonine residue of host Rho GTPases RhoA, Rac and Cdc42. The resulting AMPylation prevents the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in infected cells.", "AFDB_id": "AF-Q87P32-F1-model_v4" }, { "swissprot_id": "P03069", "sequence": "MSEYQPSLFALNPMGFSPLDGSKSTNENVSASTSTAKPMVGQLIFDKFIKTEEDPIIKQDTPSNLDFDFALPQTATAPDAKTVLPIPELDDAVVESFFSSSTDSTPMFEYENLEDNSKEWTSLFDNDIPVTTDDVSLADKAIESTEEVSLVPSNLEVSTTSFLPTPVLEDAKLTQTRKVKKPNSVVKKSHHVGKDDESRLDHLGVVAYNRKQRSIPLSPIVPESSDPAALKRARNTEAARRSRARKLQRMKQLEDKVEELLSKNYHLENEVARLKKLVGER", "function": "Master transcriptional regulator that mediates the response to amino acid starvation. Binds variations of the DNA sequence 5'-ATGA[CG]TCAT-3' in canonical nucleosome-depleted 5'-positioned promoters, and also within coding sequences and 3' non-coding regions. During nutrient starvation (low or poor amino acid, carbon or purine sources), it activates genes required for amino acid biosynthesis and transport, autophagy, cofactor biosynthesis and transport, mitochondrial transport, and additional downstream transcription factors. Activates transcription by recruiting multiple coactivators, including the mediator complex, the SAGA complex, and the SWI/SNF complex, to enable assembly of the pre-initiation complex at core promoters.", "AFDB_id": "AF-P03069-F1-model_v4" }, { "swissprot_id": "P96574", "sequence": "MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSIKPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLESQEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKIVGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFSLSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGVTIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYSLYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDEIAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIELKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSSKEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKDGLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGMDGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNRIFFTWMKEKNIL", "function": "Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol.", "AFDB_id": "AF-P96574-F1-model_v4" }, { "swissprot_id": "P27614", "sequence": "MIALPVEKAPRKSLWQRHRAFISGIVALIIIGTFFLTSGLHPAPPHEAKRPHHGKGPMHSPKCEKIEPLSPSFKHSVDTILHDPAFRNSSIEKLSNAVRIPTVVQDKNPNPADDPDFYKHFYELHDYFEKTFPNIHKHLKLEKVNELGLLYTWEGSDPDLKPLLLMAHQDVVPVNNETLSSWKFPPFSGHYDPETDFVWGRGSNDCKNLLIAEFEAIEQLLIDGFKPNRTIVMSLGFDEEASGTLGAASLASFLHERYGDDGIYSIIDEGEGIMEVDKDVFVATPINAEKGYVDFEVSILGHGGHSSVPPDHTTIGIASELITEFEANPFDYEFEFDNPIYGLLTCAAEHSKSLSKDVKKTILGAPFCPRRKDKLVEYISNQSHLRSLIRTTQAVDIINGGVKANALPETTRFLINHRINLHSSVAEVFERNIEYAKKIAEKYGYGLSKNGDDYIIPETELGHIDITLLRELEPAPLSPSSGPVWDILAGTIQDVFENGVLQNNEEFYVTTGLFSGNTDTKYYWNLSKNIYRFVGSIIDIDLLKTLHSVNEHVDVPGHLSAIAFVYEYIVNVNEYA", "function": "Necessary for use of certain peptides as sole nitrogen source. May also cleave intracellularly generated peptides to recycle amino acids for protein synthesis.", "AFDB_id": "AF-P27614-F1-model_v4" }, { "swissprot_id": "P38036", "sequence": "MEPFKYICHYWGKSSKSLTKGNDIHLLIYHCLDVAAVADCWWDQSVVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFDIRFQYKSAESWLKLNPATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLSEQSLGDFFSFFDAAPHPYESWFPWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDCSSLLAGFCSLADWLGSWTTTNTFLFNEDAPSDINALRTYFQDRQQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPVAPGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSPNLILAHGNSRFNHLFQSIKSRAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHTDPVENNSAYPLINWRGVNGAQRFDLLAHPEQLPPRFSIQPEPICLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQVDIDLFHARFTLNDRREKENRVISNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRPAGFEIPVATILLPDGEGYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMDEPEWVGNGMDKFESAECEKRFKARKVLQWAEEYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTWKRSFSEVVDEDGLLWLEGKQNLDGWVWQGNSIVITYTGDEGMTRVIPANPK", "function": "Acts as an endonuclease, a 3'-5'exonuclease, and an ATP-dependent dsDNA helicase. Anneals and unwinds R-loops (in which crRNA binds the target DNA, displacing the noncomplementary strand). Unwinding requires ATP, annealing does not. Required along with the Cascade complex for resistance to bacteriophage lambda infection as well as the ability to cure CRISPR-encoding high-copy number plasmid. A Cas3-CasA fusion protein purified with the Cascade complex nicks target plasmid in the presence but not absence of Mg(2+), and degrades plasmid fully in the presence of Mg(2+) and ATP, suggesting the helicase activity is required for complete degradation.", "AFDB_id": "AF-P38036-F1-model_v4" }, { "swissprot_id": "Q8G7X1", "sequence": "MSNEYPYASMRDSFDLSAYFVVGPEDCKGRPLTDVVDQALHGGATFIQLRAKEADASELTDMARDIAQIIEDNEKSDSVAFVIDDRADVVWQARRKGIKVDGVHIGQTDMEPREARALLGDEAIVGLSAETESLVRLINELPDGCIDYIGAGPLHVSTTKPEASVGGNDGSGKTLDAAQINTICVASEFPVVVGGGVTAADMAMLADTKAAGWFVVSAIAGAENPEEAARTMVEGWKAVRGDKKHGYAPRVVTHTPATDTQAAQEGAAKPGSEATEKKFTNAKDAKDAQKLAKQQRVDIAARGSKQRDKAHIRKTKSVPFTYQYGSYDLEVPYTEIKLSDTPGVGPNPPFHDYNTEGPKCDPKEGLKPLRLDWIRDRGDIEDYEGRRRNLEDDGKRAIKRGRATKEWRGRKHEPMRAKDHPITQMWYARHGIITPEMQYVATRENCDVELVRSELAAGRAVMPCNINHPEAEPMIIGSAFLTKLNANMGNSAVTSSIDEEVEKLTWATKWGADTVMDLSTGNDIHTTREWILRNSPVPIGTVPMYQALEKVEDDASKLSWELFRDTVIEQCEQGVDYMTIHAGVLLRYVPLTANRVTGIVSRGGSIMADWCLRHHQESFLYTHFDELCDIFAKYDVAFSLGDGLRPGSLADANDAAQLSELMTLGELTERAWAKDVQVMIEGPGHVPFDTVRMNIELEKAVCHNAPFYTLGPLTTDTAPGYDHITSAIGATEIGRYGTAMLCYVTPKEHLGLPNKDDVKQGVIAYKIACHAADIAKHHPHAMDRDNAISKARFEFRWLDQFNLSYDPDTAIAFHDDTLPAEPAKMAHFCSMCGPKFCSMAISQNIRKAFGGEAAQQQIVKEAAAGIDSEALATAKANVDNGVVSANVLSPEEILAGMDAMSEKYTAQGGKLYSTAQE", "function": "Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.", "AFDB_id": "AF-Q8G7X1-F1-model_v4" }, { "swissprot_id": "O94302", "sequence": "MDKSDSLLQSSSKGLRSSIFFQGSSRILTFFLNQLTIRLTSPSAYAFSSIHFEILQSTILFLSRESVRLAMQRIPSENAIITSTSTESNKSKKLSDQLQLIKNTSLISVYIGIVISLLVSLFYFYSLPNFPYSKTCIFIYTVSSFIELLSEPYYEVLQWRQKFSKTASAEGLGTIICSLLSFAISVLGRNKAPSSLPFALGNLSEKVTIFFTLRYFAKQPFSIFLHKVGENERYIFWDSSTLRIICSHTYQVLLKHLITKGDKIMVAWYASPSAQGPYALASNYGSLLARIVFRPVEDHSHIVFAQLTHYKNKKDEKKALNLLAWILKLYSYMSLFILFGSNYSDIVLLFGAGSKWASPDSSSILSWYAMYIPFMAANGVLEAFYVSAANSSQLYDQGKCYLASAVFYFITGKFLLSWFNLGSHGLILANILNLSLRICFALRFILHNYKDFSLPRSLPRPFLLALSILLSIISSFLVKHWRESKVPFLVYFLSAPSLAILYSCFIILVDKDVRGYAKILLSKYYIK", "function": "May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.", "AFDB_id": "AF-O94302-F1-model_v4" }, { "swissprot_id": "Q00982", "sequence": "MKTIAAYLVLVFYASTALSESISENLAWNKEFSSESVHGVFVLCKSSSNSCTTNNAARASTAYIPASTFKIPNALIGLETGAIKDERQVFKWDGKPRAMKQWEKDLKLRGAIQVSAVPVFQQIAREVGEIRMQKYLNLFSYGNANIGGGIDKFWLEGQLRISAFNQVKFLESLYLNNLPASKANQLIVKEAIVTEATPEYIVHSKTGYSGVGTESSPGVAWWVGWVEKGTEVYFFAFNMDIDNESKLPSRKSISTKIMASEGIIIGG", "function": "Hydrolyzes both oxacillin and methicillin.", "AFDB_id": "AF-Q00982-F1-model_v4" }, { "swissprot_id": "Q4FE45", "sequence": "MGNSFGCSASGERLVSAARDGDFVEAKMLLDCNPCLAKYSTFGGLNSPLHFAAAKGHNEIVGLLLENGADVNSRNYCGQTALMQACRYGHWEVVQTLLLFRCNVTRADYLAGRTALHFAAVNGHARCIRLVLADFLPSDKLNSLPETGVVTAKNKSEQSALSKFVNKAADGGITALHMAALNGLFDCVQLLLDLEANVSAVTFHYGTSMDMIGAGSTPLHYAACGGNLKCCQILLARGARKMTLNCNGWLPIDIARMWSRHWLEPLLSPNSDVVIPAFPHSNYLSLPLLSILNIAREFGLQSATIGDEVDICAVCLERTCTVAAEGCEHQLCVRCALYLCSSSNVPSVTVGPPGSIPCPLCRHGITAFKRLPSSLTREMKLPMSLGFCAPCMLHTGDTTDQSSPTCPPTEQRSSKTRAASVSSDIFCPVTCSPFPSVNIPMCTCNEGTCPNFETHGTERHSEEHVESSPSRTTTEQEKIEEGQRLGKTTTCSSMFWGRRSCSRENQCNSEINA", "function": "Possesses E3 ubiquitin-protein ligase activity when associated with the E2 enzyme UBC8 in vitro.", "AFDB_id": "AF-Q4FE45-F1-model_v4" }, { "swissprot_id": "I6X8D2", "sequence": "MADVAESQENAPAERAELTVPEMRQWLRNWVGKAVGKAPDSIDESVPMVELGLSSRDAVAMAADIEDLTGVTLSVAVAFAHPTIESLATRIIEGEPETDLAGDDAEDWSRTGPAERVDIAIVGLSTRFPGEMNTPEQTWQALLEGRDGITDLPDGRWSEFLEEPRLAARVAGARTRGGYLKDIKGFDSEFFAVAKTEADNIDPQQRMALELTWEALEHARIPASSLRGQAVGVYIGSSTNDYSFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDFHGPSVTIDTACSSSLVAIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGAVLAPDGRIKSFSADADGYTRSEGGGMLVLKRVDDARRDGDAILAVIAGSAVNHDGRSNGLIAPNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTILGDPIEAEALGRVVGRGRPADRPALLGAVKTNVGHLESAAGAASMAKVVLALQHDKLPPSINFAGPSPYIDFDAMRLKMITTPTDWPRYGGYALAGVSSFGFGGANAHVVVREVLPRDVVEKEPEPEPEPKAAAEPAEAPTLAGHALRFDEFGNIITDSAVAEEPEPELPGVTEEALRLKEAALEELAAQEVTAPLVPLAVSAFLTSRKKAAAAELADWMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGKQAPNVFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVDALVQDELGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLRHHGAKPAAVIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFARKFATKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPIHDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVALTTADAGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLFSRASGPQDYANIPPTRFKRKEHWLPAHFSGDGSTYMPGTHVALPDGRHVWEYAPRDGNVDLAALVRAAAAHVLPDAQLTAAEQRAVPGDGARLVTTMTRHPGGASVQVHARIDESFTLVYDALVSRAGSESVLPTAVGAATAIAVADGAPVAPETPAEDADAETLSDSLTTRYMPSGMTRWSPDSGETIAERLGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQLTAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQKTQTAEEIARAQAELLHGKVGKTEPVDSEAGVALPSPQNGEQPNPTGPALNVDVPPRDAAERVTFATWAIVTGKSPGGIFNELPRLDDEAAAKIAQRLSERAEGPITAEDVLTSSNIEALADKVRTYLEAGQIDGFVRTLRARPEAGGKVPVFVFHPAGGSTVVYEPLLGRLPADTPMYGFERVEGSIEERAQQYVPKLIEMQGDGPYVLVGWSLGGVLAYACAIGLRRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEKTFNVTIPAIPYEQLEELDDEGQVRFVLDAVSQSGVQIPAGIIEHQRTSYLDNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVSDLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADRTSEVGKQ", "function": "Involved in the biosynthesis of mycolic acids. Forms, with FadD32, the initiation module of the mycolic condensation system. Synthesizes, in coupled reaction with FadD32, the biosynthetic precursors of mycolic acids, alpha-alkyl beta-ketoacids, via the condensation of two long chain fatty acid derivatives, a very long meromycoloyl-AMP and a shorter 2-carboxyacyl-CoA. The acyl chain of the acyl-AMP produced by FadD32 is specifically transferred onto the N-terminal ACP domain of Pks13, and then transferred onto the KS domain. The extender unit carboxyacyl-CoA is specifically loaded onto the AT domain, which catalyzes the covalent attachment of the carboxyacyl chain to its active site, and its subsequent transfer onto the P-pant arm of the C-terminal ACP domain. The KS domain catalyzes the condensation between the two loaded fatty acyl chains to produce an alpha-alkyl beta-ketothioester linked to the C-ACP domain. Then, the thioesterase-like domain acts as a transacylase and is responsible for both the release and the transfer of the alpha-alkyl beta-ketoacyl chain onto a polyol acceptor molecule, particularly trehalose, leading to the formation of the trehalose monomycolate precursor.", "AFDB_id": "AF-I6X8D2-F1-model_v4" }, { "swissprot_id": "Q99394", "sequence": "MSSTHSNNVGHPQSSPQGPLTEQQRAQQQYQIFENSLPKVSQSVYQMLLNEMVPLAMGIERQISGDVISSDSNVTSENGNINNMIKRLKIEEHHTVDIIRSHNLIHELYKADEEEKEKVLARLRNIGFQIGLKLSELLIFSNNPNLKFKEMDLLLIMKFICRDVWKQIFGKQIDNLKTNHRGTFYLLDYDYRPIQSFSLEEDAKNEELKMIEPFLEIPVGIIRGVLSSLGYSSEEVICLASFIDRPTDRPKTAFPKGVSFHVQVTMPQ", "function": "Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.", "AFDB_id": "AF-Q99394-F1-model_v4" }, { "swissprot_id": "Q8SQJ8", "sequence": "MIEGLKVKALICVVEIIENGINSIHAMGILLFALNILKKASVLVSRILCAWNGKLSSEYPRDPRSRLGIFKNMNIAFICDGNRRYARKLGLEDSFIKDKGLQKIYEFIEFGCFYGIKEISFFCFALSNFKRSPEEVNKLMGLVKQKIERPKEIGIRPKFRVYGRLDLLEEDVRKRLMDIEEESKNNTSIIVNIFFAYSAEDEITRGIQFNSHVDILIRTSNTKRLSNFMIRQVAKGTSVFFAKALWPELTTAHLFLILLKHRLENKYLLG", "function": "Cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP).", "AFDB_id": "AF-Q8SQJ8-F1-model_v4" }, { "swissprot_id": "Q9RTI0", "sequence": "MPTVHVFARDHINTDEIIPARHLTTDVESELAKYAMEDYDKDFVRRVQPGDIIVAGADFGCGSSREHAVWALRGAGVSAVIAPNFARIYYRNSINNGFLALECEGITELFQDGEEAELDLKGGTIRNPRTGKELSFVPVPQFALDVQKAGGWLEYMKAGEDVEGERLDNASTSAGHGHAGTPLGDDPAKEDGPRPEQASGHQKEEHHA", "function": "Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.", "AFDB_id": "AF-Q9RTI0-F1-model_v4" }, { "swissprot_id": "Q9LYC7", "sequence": "MADNKTSEGIVSEETPMDASQEQQHETVEEMLARHRQEIKQLQNKETEMKKAAAKGSKAEQKAKKKQVEDDISKLSTKLKDKQLKELASQGFSSSSSNNIAKDETTEKKGDIDTLVRAIAGVSVTAQQEHSKPSKSVKRREKRAKEEADREQRIKEEQSHVKSDRMVENAKLEKKLKPLGLTVSEIKPDGHCLYRAVENQLANRSGGASPYTYQNLREMAASYMREHKTDFLPFFLSETEGDSNSGSAEERFEKYCREVESTAAWGSQLELGALTHCLRKHIKVYSGSFPDVEMGKEYRSGDDSSLMLSYHRHAFGLGEHYNSVVLVNNITG", "function": "Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (Probable). Inactive cysteine protease. Deubiquitinating enzyme which regulates gene expression by contributing to chromatin organization and DNA methylation patterns (e.g. H3K4me3 and H3K27me3). Involved in the interpretation of environmental information, probably by altering chromatin organization and maintaining redox homeostasis. Required for phosphate (Pi) homeostasis (e.g. responses upon Pi starvation including DNA methylation and histone methylation). Negative regulator of root hair morphogenesis.", "AFDB_id": "AF-Q9LYC7-F1-model_v4" }, { "swissprot_id": "Q3UW26", "sequence": "MAQPLDFLLVSICLFHSLFSFQVEDYYAPTIESLIRNPETEDGACVFPFLYRSEIFYDCVNFNLKHKWCSLNKTYQGYWKYCALSDYAPCAFPFWYRHMIYWDCTEDGEVFGKKWCSLTPNYNKDQVWKYCIE", "function": "Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.", "AFDB_id": "AF-Q3UW26-F1-model_v4" }, { "swissprot_id": "P38759", "sequence": "MLLLALSDAHIPDRATDLPVKFKKLLSVPDKISQVALLGNSTKSYDFLKFVNQISNNITIVRGEFDNGHLPSTKKDKASDNSRPMEEIPMNSIIRQGALKIGCCSGYTVVPKNDPLSLLALARQLDVDILLWGGTHNVEAYTLEGKFFVNPGSCTGAFNTDWPIVFDVEDSDEAVTSEVDKPTKENQSEDDDAKGGSTGKEQPGSYTPKEGTAGERENENESNVKPENQFKEDEVDMSDSDINGSNSPSFCLLDIQGNTCTLYIYLYVNGEVKVDKVVYEKE", "function": "Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection.", "AFDB_id": "AF-P38759-F1-model_v4" }, { "swissprot_id": "Q1MQD8", "sequence": "MIYSHLSSTSCTITTGCKVNLNLYITGILPNGWHKIDSIFLPLSEPHDELHIEITNHNQGLHLSCNILDIELENNILTKTYTLFTKATHFTPSISIYLKKGIPYGAGLGGGSSDAAALLTWLQKNSPLPLSPSKLLKLAAEIGADVPFFLKNKPCRATGIGEKLEEISLSNLNISGNTLFIICPNLKISTPYAYKMWDDYNKKQIATSSRYNNNLTKKYSWDRSSPSTHLSDYLWMKNDFEPVIFSEYTELSVFKEQLLQFGARAAVLSGSGSSIYGLFKEYNQTSIMTEFYKKKNILTFSQLLQ", "function": "Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.", "AFDB_id": "AF-Q1MQD8-F1-model_v4" }, { "swissprot_id": "P35338", "sequence": "MACTDNAMRALFLLVLFCIVHGEKEESKGIDAKASGPGGSFDITKLGASGNGKTDSTKAVQEAWASACGGTGKQTILIPKGDFLVGQLNFTGPCKGDVTIQVDGNLLATTDLSQYKEHGNWIEILRVDNLVITGKGNLDGQGPAVWSKNSCTKKYDCKILPNSLVMDFVNNGEVSGVTLLNSKFFHMNMYQCKNMLIKDVTVTAPGDSPNTDGIHMGDSSGITITNTVIGVGDDCISIGPGTSKVNITGVTCGPGHGISIGSLGRYKDEKDVTDINVKDCTLKKTMFGVRIKAYEDAASVLTVSKIHYENIKMEDSANPIFIDMKYCPNKLCTANGASKVTVKDVTFKNITGTSSTPEAISLLCTAKVPCTGATMDDVNVEYSGTNNKTMAICTNAKGSTKGCLKELACF", "function": "May function in depolymerizing pectin during pollen development, germination, and tube growth. Acts as an exo-polygalacturonase.", "AFDB_id": "AF-P35338-F1-model_v4" }, { "swissprot_id": "A7VMU4", "sequence": "MVAWNGTLVRPKLLIGASCQCVYNIYLHPLRHYPGPKLAAATGLYHWYWTLAGRIHRQLHKLHRQHGEVVRIGPDRLSFIAPEAWKDIYGPGTTSHKENKKDGRFYAPTPNGRRAMISLLDNQHHASVRRVFQPAFSDRSLRALEPVINKHVKRLMHTNLRQLARADEPFDLVHLLNCAIFDIMGDLMLSESFGMLEQSAYVEWIETLLVALRYESVGQFLLEYATLGKLLSFLMPPSARRKREQHVQYTAQRVDKRQQKSEATKRDIWGFLAAHENAEMLDIEDKHANASLFMVAGTETTITALSGLVFLLLQHPPCMRRLVAEIRDSFTCEDAINMDTLQGLSYLNACLSEALRLYPPVPLGNPRVTPADGNVICGHAVPGHTRVYVSTWAACRSASNFGDADSFMPERWLPDSGYDSDRKEASKPFSYGPRNCIGKSMAYHNIRIIIARILWNYDLLAAAESDGWMKQECFPLWDKKPLMVRVMLR", "function": "Cytochrome P450 monooxygenase; part of the gene clusters that mediate the biosynthesis of AM-toxins, host-selective toxins (HSTs) causing Alternaria blotch on apple, a worldwide distributed disease. AM-toxins are cyclic depsipeptides containing the 3 residues 2-hydroxy-isovaleric acid (2-HIV), dehydroalanine, L-alanine which are common for all 3 AM-toxins I to III. The fourth precursor is L-alpha-amino-methoxyphenyl-valeric acid (L-Amv) for AM-toxin I, L-alpha-amino-phenyl-valeric acid (L-Apv) for AM-toxin II, and L-alpha-amino-hydroxyphenyl-valeric acid (L-Ahv) for AM-toxin III (Probable). AM-toxins have two target sites for affecting susceptible apple cells; they cause invagination of the plasma membrane and electrolyte loss and chloroplast disorganization. The non-ribosomal peptide synthetase AMT1 contains 4 catalytic modules and is responsible for activation of each residue in AM-toxin. The aldo-keto reductase AMT2 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV), one of the precursor residues incorporated by AMT1 during AM-toxin biosynthesis, by reduction of its ketone to an alcohol. The cytochrome P450 monooxygenase AMT3 and the thioesterase AMT4 are also important for AM-toxin production, but their exact function within the AM-toxin biosynthesis are not known yet. Up to 21 proteins (including AMT1 to AMT4) are predicted to be involved in AM-toxin biosynthesis since their expression ishighly up-regulated in AM-toxin-producing cultures.", "AFDB_id": "AF-A7VMU4-F1-model_v4" }, { "swissprot_id": "Q8U0K8", "sequence": "MAEARDLFKEFKVQSVSEFFRRNAAMLGYTGSIRSLTTVIHEAVTNSLDACEEAGILPYVRVEIEELGKEHYKVIVEDNGPGIPEDYIPHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGDDEIVEAWVKIDVQKNEGKIVKKIKHPNPKRWRGTRIELEVKNVKYVRSKQGVYWYLKLTAIANPHAHIELVEPDGKLIVFPRSSEDIPEPPVEMKPHPKGVMTDDVYTMAHRSKRSTVRRFLVSEFSRISDKKVDELVLYIAALRLINREVTDQNLKSQLIERLANGEVEKVLKSFGRKWKKVVEEVEKIMEKPPEKLTWHEAEEIVEAFKLMKFLAPPTYGLRPIGEENIEKGLSSILRPEFVTAVTRPPKVYSGGIPFQVEVGIAYGGEITNSEILRYANRVPLLFDAGSCVITSAVRSIDWRRYRVESFDNAPLVVLVNVVSVHVPYTSTGKQSIASIDEIYNEIRLALMEAARRLAAYLGGKYRRLYQIRRKKIFEKYLPEIARSLHILTGEPEEKIKEYFLRLIESKITVAQEGVSEVEVEEGEA", "function": "Relaxes both positive and negative superturns and exhibits a strong decatenase activity.", "AFDB_id": "AF-Q8U0K8-F1-model_v4" }, { "swissprot_id": "P45897", "sequence": "MFHPGMTSQPSTSNQMYYDPLYGAEQIVQCNPMDYHQANILCGMQYFNNSHNRYPLLPQMPPQFTNDHPYDFPNVPTISTLDEASSFNGFLIPSQPSSYNNNNISCVFTPTPCTSSQASSQPPPTPTVNPTPIPPNAGAVLTTAMDSCQQISHVLQCYQQGGEDSDFVRKAIESLVKKLKDKRIELDALITAVTSNGKQPTGCVTIQRSLDGRLQVAGRKGVPHVVYARIWRWPKVSKNELVKLVQCQTSSDHPDNICINPYHYERVVSNRITSADQSLHVENSPMKSEYLGDAGVIDSCSDWPNTPPDNNFNGGFAPDQPQLVTPIISDIPIDLNQIYVPTPPQLLDNWCSIIYYELDTPIGETFKVSARDHGKVIVDGGMDPHGENEGRLCLGALSNVHRTEASEKARIHIGRGVELTAHADGNISITSNCKIFVRSGYLDYTHGSEYSSKAHRFTPNESSFTVFDIRWAYMQMLRRSRSSNEAVRAQAAAVAGYAPMSVMPAIMPDSGVDRMRRDFCTIAISFVKAWGDVYQRKTIKETPCWIEVTLHRPLQILDQLLKNSSQFGSS", "function": "Involved in TGF-beta pathway.", "AFDB_id": "AF-P45897-F1-model_v4" }, { "swissprot_id": "P32784", "sequence": "MPAPKLTEKFASSKSTQKTTNYSSIEAKSVKTSADQAYIYQEPSATKKILYSIATWLLYNIFHCFFREIRGRGSFKVPQQGPVIFVAAPHANQFVDPVILMGEVKKSVNRRVSFLIAESSLKQPPIGFLASFFMAIGVVRPQDNLKPAEGTIRVDPTDYKRVIGHDTHFLTDCMPKGLIGLPKSMGFGEIQSIESDTSLTLRKEFKMAKPEIKTALLTGTTYKYAAKVDQSCVYHRVFEHLAHNNCIGIFPEGGSHDRTNLLPLKAGVAIMALGCMDKHPDVNVKIVPCGMNYFHPHKFRSRAVVEFGDPIEIPKELVAKYHNPETNRDAVKELLDTISKGLQSVTVTCSDYETLMVVQTIRRLYMTQFSTKLPLPLIVEMNRRMVKGYEFYRNDPKIADLTKDIMAYNAALRHYNLPDHLVEEAKVNFAKNLGLVFFRSIGLCILFSLAMPGIIMFSPVFILAKRISQEKARTALSKSTVKIKANDVIATWKILIGMGFAPLLYIFWSVLITYYLRHKPWNKIYVFSGSYISCVIVTYSALIVGDIGMDGFKSLRPLVLSLTSPKGLQKLQKDRRNLAERIIEVVNNFGSELFPDFDSAALREEFDVIDEEEEDRKTSELNRRKMLRKQKIKRQEKDSSSPIISQRDNHDAYEHHNQDSDGVSLVNSDNSLSNIPLFSSTFHRKSESSLASTSVAPSSSSEFEVENEILEEKNGLASKIAQAVLNKRIGENTAREEEEEEEEEEEEEEEEEEGKEGDA", "function": "Dual substrate-specific glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase, catalyzing the first and committed reaction in the de novo synthesis of glycerophospholipids and triacylglycerols (TAGs). Prefers Gly-3-P over dihydroxyacetone phosphate and has a marked preference for 16-carbon fatty acyl chains. Transfers a fatty acid from fatty acyl-CoA to the sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid (LysoPA). These lipids not only are precursors of glycerolipids, but also are dynamic components of signal transduction systems that control cell physiology. SCT1 is the primary supplier of diacylglycerols (DAG), used mainly in TAG synthesis and phosphatidylcholine (PC) synthesis through the CDP-choline pathway. Regulates fatty acid desaturation, that is, the ratio of unsaturated versus saturated fatty acyl chains, by competing with the desaturase OLE1 for the common substrate C16:0-CoA. Sequesters C16:0-CoA into lipids, thereby shielding it from desaturation by OLE1.", "AFDB_id": "AF-P32784-F1-model_v4" }, { "swissprot_id": "Q44643", "sequence": "MEKDISRKIDLLNILIEEKRWFTLFELEKNLNCSSKTIRKDISIINDLLPKTIFIHSKKGKGVKLSLPQNQSISEAISNLLKKSLTFLAIQQLLEERSNTVTSLADKLYLPISSTNIVLKRVSKYIKKFGLSLEKKPLRIVGDEFQIILMFSERYLESYPDTEWPFTEYKEEMLIDYINYIEEKLEIVFYSNDKRRMAFIMTILFKRIKQGHKVKFSEWIIKETMESIYYKKIFEGKNVIKVNKNRSLNIEEQVLLVIMVKLSRYVSKDENNLKQEELVLYKEGESTTYTYVKNFISILEQELKIDLNNNEEFVYGMIEYCREAFHILKFIPILKAPEKDTCKYIKKHYEETFYLVKRAYNKWGAEMKLTDIPDEEIAKVTMRIVAIGKQHNINRKKVLLITGEGKSWEEYMKSRINKRYGDQLKFVGGHAKILNGNTDNIDNIDIDFIITTVPLNFSWKSIVYVSPILQERDFYEIGIFASK", "function": "AcpA and AcpB regulate cap gene expression and capsule synthesis.", "AFDB_id": "AF-Q44643-F1-model_v4" }, { "swissprot_id": "C5D754", "sequence": "MNKMAGVVLAGGQSRRFGSPKAFAKFNGKYFFEIAVETLRTVVEDIYIVSHPSLIDCFRQKTAEKVIMDDERYRGQGPLAGIYTVMKECEAEWIFVLPCDMPYMRPEAAAKLAKYANEKFDAIICAHFGRIQPLVGIYHRRTCKQIEKLLQAQDNRMKSLFRHCHVHYVNEQDFWEDEIVFRNVNTPNEFDDIVT", "function": "Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.", "AFDB_id": "AF-C5D754-F1-model_v4" }, { "swissprot_id": "Q6AH30", "sequence": "MTDPPALSALTTMRVGGTPERLLEPADRDALVATAREVWSTGDEWLLLGGGSNTIAADDGFEGTVLRIVTRGVERLAAEKGRIRLRVQAGEPWDALVALTVRNGWAGIEALSGIPGSTGAAPVQNIGAYGQEIESALIGVEFLDYLTGEVYTLARAELGLGYRTSALKRGMAGVVLSVDLELADHSVPGGVGASLSAPIAYAQLADALAVPLGSRVSVDELRRAVLALRASKGMVLDPADPDSVSAGSFFTNPIVSENVARALPSDAPRWSLGPPEPDTILSLGPEGVHPLDVPPFAAGPYEAKLSAAWLIENAGIRSGFALPGSGAAISSKHTLAIVNRGAATAADVAQLASFVRGRVQADFGVVLHPEPVLVGLTL", "function": "Cell wall formation.", "AFDB_id": "AF-Q6AH30-F1-model_v4" }, { "swissprot_id": "A2RVJ8", "sequence": "MKKGAKRKGVSKAGRKAAVAETQNDEVIEETTKTTQEESQQHEEEVVDEVKENGEEEEAKGDQEEEEDAKPDSLEEDEENQEDEVKAEEVKEEVEKKPVARRGGKRKRATKKDTEIKDEKKPVPKAKKPRAAKVKEEPVYFEEKRSLEDLWKVAFPVGTEWDQLDALYEFNWDFQNLEEALEEGGKLYGKKVYVFGCTEPQLVPYKGANKIVHVPAVVVIESPFPPSDKIGITSVQREVEEIIPMKKMKMDWLPYIPIEKRDRQVDKMNSQIFTLGCTQRRSALRHMKEDQLKKFEYCLPYFYQPFKEDELEQSTEVQIMFPSEPPVVCEFDWEFDELQEFVDKLVEEEALPAEQADEFKEYVKEQVRAAKKANREAKDARKKAIEEMSEDTKQAFQKMKFYKFYPQPSPDTPDVSGVQSPFINRYYGKAHEVL", "function": "Essential protein required for basal thermotolerance, especially during heat-induced chromocentre decondensation, thus regulating transcriptional gene silencing (TGS).", "AFDB_id": "AF-A2RVJ8-F1-model_v4" }, { "swissprot_id": "B9KI89", "sequence": "MRVLLTNDDGFDSVGMRVLRDVVSGHFAEVWVSAPARDCSAASRALSVRTPIKTHMRGEREFVVHGTPADSAVIGICEMTSTGKRPDLVISGINYGANTGFTVPYSGTIAAAAAAFDIGVPAIAISQQYNGKRCDNNVETSWQNSRKSVMALVSRLLRDTMWHGKCIMSINVPYSDVQGVKFAGHSCDDGHIKWDGPSMERREITSGDGRCVSYVFDDMRSPNSNDNASDTQLLEQGYIVVTPIGHSMTDHATLDKYCGLQ", "function": "Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.", "AFDB_id": "AF-B9KI89-F1-model_v4" }, { "swissprot_id": "C5BHA4", "sequence": "MNRLALYCRPGFEKECAAEITDKAAALEVYGFARVKENSGYVLFECYQPDDADTLARKLPFRELIFARQMLVVGELLKDLPPEDRIAPICGMLLGVVEGGGELRVEVPDTNESKELLKFCRKFTVPLRAALREQRTLLRQENPYRPVVHVLFIAPGCCYVGYSYSDNNSPFYMGIPRLKFPADAPSRSTLKLEEAFHVFIPADEWDERLGSGMRAVDLGACPGGWTYQLVQRSMMVQAIDNGPMVPSLMETGQVTHHRADGFRFTPEGDNDWLVCDMVEKPAKVSALMARWLVNGWCREAIFNLKLPMKKRYEEVSQNLATLAQVLKENGINAQIAAKQLYHDREEVTVHVRRIWGAIPGRRDEREFRRREQRD", "function": "Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.", "AFDB_id": "AF-C5BHA4-F1-model_v4" }, { "swissprot_id": "G4NFB7", "sequence": "MSCISRSRALFQIRSLASSSHLPLPKLRPSPAIYKSANKTAFNASPSTSQSATTTRGFRSTAAKMTVHNLTNAQDFKDALKSHKFVLVDFFATWCGPCRAIAPKIAEWSDAFPNIHYVKVDVDEVPDVAQEYNVRAMPTFLLFKDGEKVDEVVGANPPKLQALISANHPSS", "function": "Thioredoxin involved in responses to oxidative and cell wall stresses. Plays an important role in appressorium formation on hyphal tips. TRX2 may affect invasive growth via the MST11-MST7-PMK1 pathway since it is required for the proper folding or dimerization of MAPKK MST7.", "AFDB_id": "AF-G4NFB7-F1-model_v4" }, { "swissprot_id": "A1BJG0", "sequence": "MRRKSGCSAGLDDRSAYEEVVLDSMLYSARLKETVARGNSAVVVAMARLIAGVFETGGKLLICGNGGSAADAQHLATEFTIRYRSSVHRPALPAIALTTDSSALTAGANDLGYDEVFRRLVEAYGRPGDLLLGLSTSGNSRSVVHALDYARKHGMRTLALLGGDGGALKGLADLSVVVPHNGSADRVQECHITLGHVIIDLVERMMGYGTECNNQQNEQGYADQTD", "function": "Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.", "AFDB_id": "AF-A1BJG0-F1-model_v4" }, { "swissprot_id": "C0NZU3", "sequence": "MGFNIPWNGTQAEYHVTHCFLPSDKIDLISFSTSTSQFCNGRPFKFVPAALPSILPQAKPITTDQTQAPPPALAQPSLSFTQGLLVGQLSVVLLIGAFIKFFIFGEAPPPPSRSGLYNRTSSHRRSYSINAISTDFSPRTLREKPSTSNILRPVPSSSTNTRSILRKTYYSATPTNPTSKHGRSRVHHSSHQPESLDWFNVLIAQTIAQYRQTAYILKDSPTSSILASLSEALNNPEKKPSFIDTIKVTDISLGEEFPIFSNCRVIAVEDPNSDGGRLQALMDVDLSDDNLSLAVETSLLLNYPKPFSAVLPVALAVSVVRFSGTLCISFVPGPGTSDQTMGPSASPPNQSTSTETASINDQTSEGQSTQRHTFHQHKPTNSTPTAATADDAHTKHAHGIPKTSLAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARMQAWFEERVVEPRVQVVGLPNIWPRMGRTGVRGSQEEAEARAGVGSVPVDIPGTAGGDGMRGRGGGGGGGGLRGNSSGRGMGYDGLRYRPNAHGDGGTGVVQGQGAGGIFCEAGPQNQNRGGDDGEGPGRRSDERFAMPGSMPDSVAVT", "function": "Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.", "AFDB_id": "AF-C0NZU3-F1-model_v4" }, { "swissprot_id": "Q9UTB8", "sequence": "MSKHHPDLVLCRRQPGITVGKLCERCDEKCPICDSHVRPTTLVRICDECAFGSSQDRCIICGAPGVSDCYYCSECTRMEYDRDGCPRVINLGSSRTDWFYERKKFKNAGKEMPGATY", "function": "Required for pre-mRNA splicing.", "AFDB_id": "AF-Q9UTB8-F1-model_v4" }, { "swissprot_id": "D7GXF9", "sequence": "MKLSNQFLITITLLITSITFAQEAPHFKPGEDPRQPHQEWKLIENMSDEFEGKKIDEKKWQISGQGWIGRAPGLFLAENISLNNGSLQITTTMLPEPIVKNNKTYTHGGGYVGSRNGMTYGYYECEMKANKTFMSSTFWLINEGKDRLGCDKRTTELDIQESVGQITNDADWMKYFDQTMNSNTHSRNIPEGCEYEKGSSKGKAELGGKAYEDFHVYGVWWKSKDEIIFFLDGKMQSKVTPPADFDIEMYLRMVVETYDWNPVPKDGGMTGSKEDRTTTYNWVRSWQLVDSKN", "function": "Cleaves the sulfated polysaccharide porphyran at the (1->4) linkages between beta-D-galactopyranose and alpha-L-galactopyranose-6-sulfate, forming mostly the disaccharide alpha-L-galactopyranose-6-sulfate-(1->3)-beta-D-galactose. Some longer oligosaccharides of even number of residues are also observed. Inactive on the non-sulfated agarose portion of the porphyran backbone. In contrast to PorA, tolerates the presence of 3-6-anhydro-L-galactose in subsite -2.", "AFDB_id": "AF-D7GXF9-F1-model_v4" }, { "swissprot_id": "O67295", "sequence": "MEQQSPVGALLFQIIFLVAIFLMFYFLIIRPQKKERERHRKFLESLKKGDKVITSSGIWGTVVEIGDRTITLKVDANTKITFSKEAIVAYQPGYEKKEEKKD", "function": "The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.", "AFDB_id": "AF-O67295-F1-model_v4" }, { "swissprot_id": "Q9FK72", "sequence": "MDENNGGSSSLPPFLTKTYEMVDDSSSDSVVAWSENNKSFIVKNPAEFSRDLLPRFFKHKNFSSFIRQLNTYGFRKVDPEKWEFLNDDFVRGRPYLMKNIHRRKPVHSHSLVNLQAQNPLTESERRSMEDQIERLKNEKEGLLAELQNQEQERKEFELQVTTLKDRLQHMEQHQKSIVAYVSQVLGKPGLSLNLENHERRKRRFQENSLPPSSSHIEQVEKLESSLTFWENLVSESCEKSGLQSSSMDHDAAESSLSIGDTRPKSSKIDMNSEPPVTVTAPAPKTGVNDDFWEQCLTENPGSTEQQEVQSERRDVGNDNNGNKIGNQRTYWWNSGNVNNITEKAS", "function": "Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). May be involved in general response to auxin.", "AFDB_id": "AF-Q9FK72-F1-model_v4" }, { "swissprot_id": "O31266", "sequence": "MTDTYLHETLVFDNKLSYIDNQRDTDGPAILLLPGWCHDHRVYKYLIQELDADFRVIVPNWRGHGLSPCEVPDFGYQEQVKDALEILDQLGVETFLPVSHSHGGWVLVELLEQAGPERAPRGIIMDWLMWAPKPDFAKSLTLLKDPERWREGTHGLFDVWLDGHDEKRVRHHLLEEMADYGYDCWGRSGRVIEDAYGRNGSPMQMMANLTKTRPIRHIFSQPTEPEYEKINSDFAEQHPWFSYAKLGGPTHFPAIDVPDRAAVHIREFATAIRQGQ", "function": "Ring-cleaving dioxygenase involved in quinaldine degradation and utilization.", "AFDB_id": "AF-O31266-F1-model_v4" }, { "swissprot_id": "A2YFN7", "sequence": "MSAAAASSAAGDSAKQPLLHHQRGNPPHVASVSSPSLPSAPPGALAGGRRFPGGLDVPNLKKRGGGTRSWIRVEAATASVQTLEVDKATMMRRCELPARDLRLLDPLFVYPSTILGRERAIVVNLEQIRCVITADEVLLLNSLDSYVLQYAAELQRRLLQRAEGDELPFEFRALELALEAACSFLDAQAAELEIEAYPLLDELTSKISTLNLERVRRLKSRLVALTRRVQKVRDEIEQLMDDDGDMAEMYLSEKKLRTEASFYGDQSMLGYNSVGDGTSFSAPVSPVSSPTESRKLEKAFSLCRSRHDSVKSSDNTATEHIQELEMLLEAYFVVIDSTLNKLTSLKEYIDDTEDFINIQLDNVRNQLIQFELLLTTATFVVAIFGVVAGIFGMNFETSVFSIQNAFQWVLIITGVIGAFIFCGFLWFFKYKRLMPL", "function": "Magnesium transporter that may mediate the influx of magnesium.", "AFDB_id": "AF-A2YFN7-F1-model_v4" }, { "swissprot_id": "E8RUP5", "sequence": "MRSSKIRCPGAIRVGTLVTAFGCLPHVAFAAAREAPPVTPEVLVRLADIGTMSASETTPLLSLSPDGRYVAFQVRQADPVTNLNVFRMVVKATDGATDAIDVDVGGEYLFWTIPSWGYARNAPSGANLTIQPRWSPSGTHLAYLRQDQGRVRVWRASVKGEGASPVIEDAYDIEDVQWLDDNTLIYSGRPGFVEAEAEIEREGRRGWVYDERFHPLTGARPRVLEPISIVYQVLDLKTGTRRAATPTEVARLREKPDPLRAMVGRTTFSVSRTDPQNINAPTTLVARRGEGEPVRCDEEACQNITRMWGDETANVLYFLRREGWASNEMALYRMPADALKPVRIWHATGLLQGCERQAKRLICAQESALQPRRLVTLNLTSGQMSPLYDPNPDLSRYRLPKVERLTLRNRNGIEVFSDLVLPPDYQLGTRLPLVIVQYSSRGFLRGGTGDENPILPLATAGFAVLSFHSPRSEASYQRFTSPIAQSKAEYSNWRNRWNILHTLEDLIDDLDRRGVIDPARVGLTGLSDGATTVHFGLINSHRFAAAVTSSCCTDSFTASVMNGPRISGALKAYGIETDQADDGPFWAATSFVVNASRLDTPLLIQSADEEYLGALPGFTALQQARKPVELIIYPNEHHVKWQPAHRLAVYNRTIDWFRFWLMDQSDPAPDKAAQYDRWRALRALRQKSPSPTPAP", "function": "Lasso peptide isopeptidase that specifically hydrolyzes Astexin-2 and Astexin-3, converting them to linear peptides. Has only a few specific contacts with subrates, because it recognizes Astexin knotted structure (principally the loop structure). Its binding to lasso peptides opens them to expose the isopeptide bonds for hydrolysis.", "AFDB_id": "AF-E8RUP5-F1-model_v4" }, { "swissprot_id": "P83560", "sequence": "MKTLVIACVALVLVVVHGEVIEEVNEKQLQESVEEKYSLLQRLEKLDEAITAEENRNSRVRRCGSKRAWCKEKKDCCCGYNCVYAWYNQQSSCERKWKYLFTGEC", "function": "Selectively slows channel inactivation of mammalian Nav1.1/SCN1A, Nav1.3/SCN3A, and Nav1.6/SCN8A and shows higher affinity for insect Nav1/para channels (site 3). Induces tonic repetitive firing of nerve impulses in insect neurons accompanied by plateau potentials.", "AFDB_id": "AF-P83560-F1-model_v4" }, { "swissprot_id": "E7EYQ9", "sequence": "MADVCLRLQYACPWQSNMAAHGRQPVLSSTPLQILFHLNGWYFAAFFVAEILMFIYKGVILPYPQDNLILDVVLLLLFSGLETLRLFYGWKGNLCQRSLALFVSVAILVPCAVLSVYYLLLQTFVLRLEFVLNAVLLCFYGFELVLGVMTISIFSRANIY", "function": "Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.", "AFDB_id": "AF-E7EYQ9-F1-model_v4" }, { "swissprot_id": "Q2QWE9", "sequence": "MASAGDRRGGGGPPGSGDDSGGGWETVEKRVKKPAQQVGKGQWGQWNSPNAAPAPTAPRSGSGAFHHSGNTLVRHSDRRPARGTPRPPPQNRSIEAELQAPHGVVTAPLANGWQWGARSCPPGTESKEGGLPLSGCDPETDNAEGYDTSDDDNDDDMSDDLSDDYDSDASEKSFETRKNHKLFKGFFEVLEALSVEQLNEPTRQWHCPACKNGPGAIDWYKGLQPLMTHAKTKGSIKVKRHRELASLLEEELSRRGTSVVPSGEQFRKWKGLRESTDREIVWPPMVVVMNTVLEQDEDDKWKGMGNQELIDYFSEYAASKARHAYGPNGHRGMSVLIFDSSAVGYMEAERLHDHFVRQRTDRNTWNSAHKVTFLPGGKRQLYGFLATKDDMETFNRHCHGKSRLKYEMRSYNEMVVTQMKQMSEDNQQLNYLKNKMVKKEQHSKLVEDTLSVVTQKLRETMEENTIVRNKAKEKHLEYEKEMKYQEEFFHDQIEKIHKATEEKEIKFEKLLQEERAKARQSDVDSGSTEDRRQRKEKIQNFIDCQVKDVEEFEAERDKLIKLHEEKKVKLKKEYLAKEFELEKELDTALTSLMDKHKPDIFKSSTSPST", "function": "Required for post-transcriptional gene silencing and natural virus resistance.", "AFDB_id": "AF-Q2QWE9-F1-model_v4" }, { "swissprot_id": "Q5XH09", "sequence": "MANEACPCPCDIGDKFEYGAKGQEIQIEHIKAYVSKPHSSTDKAVIVVQDIFGWQLPNTRFMADLLTAHGYITICPDFFVGQESWKPSNDWSTFTEWLQTRQATKVEKEMNVVLKYLKEQCHVKKIGVIGFCWGGVVTHHLMLKYPELKAGVSFYGIIRDVEDRYNLLNPTLFIFAEIDHVIPLEQVSLLEQKLKVHSKVDFQIKVFPKQTHGFVHRKKEDINPEDKPFIEEARKDMLEWLQKYIN", "function": "Cysteine hydrolase.", "AFDB_id": "AF-Q5XH09-F1-model_v4" }, { "swissprot_id": "Q5L4T7", "sequence": "MAVRPRIQLLDTVTINQIAAGEVIENAVSVVKELVENALDAGADEIEVETLGGGQGLIVVKDNGCGMSSDEVTLALKRHATSKIEEFSDVFSLSSFGFRGEALPAIASISKMEILSCPKGEEGSRTIIHGGEVIAAEAKPRQLGTTISVDSLFYNVPVRRGFQKSPQTNRIAMRKLLENRILSLESVGWSWISERQQEFHILKHQGLAERVAFVMGEGFMQEALRVDRVEEPIRIVGFLGSPCFHRPTRLGQRIFINDRPVDSPLISKQISEAYTMLLPPQRYPVFVLKLYLPPQWCDFNVHPQKTEVRILKEEFVREFLSESIGEVLARSQESSSYKKTSLTLPTLRFFDGQLPEISLEQPRESMSLPVTQLATPSIRSISSLGCQQEIPAVDTQTEIVWGESQEVRFLTSLGKIVLAEDSEGVHAIFTEAARKHLFYLSLIENQQEHYKSQSFLVPLCLEVTPQERVFLLSHIEEFKQLGIEISQIGPCVFAIESAPTFIGEEELKSWILSLAAESHTKVDKKAIALLIKESLTQTIFGKTLRTFDISWLSLLWQIGKPEKAFDGTLIRRLILDEDFIKE", "function": "This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.", "AFDB_id": "AF-Q5L4T7-F1-model_v4" }, { "swissprot_id": "D2PPN2", "sequence": "MAHSPGPIPRGDLVPSGIVGLLGTQGPTARTAIARTLGLSPATVTQVTKDLIARGLIEELESVPSNGGRPARLLGLVQDAGVALGAKVTADHVAIVTVELDGTVRSSVSHDYDPGADDALPRLGRILAQEVAALDDRLLGVGVGVPGSVDSQASGIVDAPTLSWQAAPVGPSLRAAIGSPVLVDNDVNTLAAAERLYGIGRAHSSYLVVTIGRGIGCGIVVDGGIYRGANGGAGEIGHIPVWHDEQDQLPCTCGSTGCLEAHVGAAGLCRTARDRGVIGPRGTLPTLLRAAATGDEAARQVFAAAGAMLGRALAGVIHTIDPEVVVLMGEGVDGWQYWQTGFEPSFRRSLLPARKAVPVVVEPWTEDQWARGAASLVLASPFDSAGTGGEQSRLVRVRLGAP", "function": "Transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes.", "AFDB_id": "AF-D2PPN2-F1-model_v4" }, { "swissprot_id": "P54211", "sequence": "MADIKEGVEEGSVKVDMIKEPLTQGDTGVDEVDFAKITLDDAFKYLNCNKHGLSSAEAAARLQQHGPNKLPDSSRNPVLVFLGYMWNPLAWAMEAAAIISIALLDVADFVLIVGLLLINAIISFYEESNADKAIKALTAALAPKAMVVRDGAIVTIDAVNLVPGDVILIRLGNIVPADVKLLEEEGADEGEQEAPMQIDQAALTGESLPAKKFTGDVAFSGSSIKQGERHAVVYATGVNTFFGRAAALISGTNNVSNLQTVMNKMSAICIVTILLWVVVELAVQFGHYSHECVGGREGCPTLLNMLVVLVGGIPIAMPTVLSVTLALGAYKLAREGAIVTRMSAVEEMAGMDVLCSDKTGTLTLNKLSIDKSMVVPVGNMGVDEIMRMGALSANTVTEEPIDMVLWESYPDRETIKRDYKHTKYFPFNPNDKITIATCLEIATGRVFRVLKGSPQVVLAKAWNAAELDATVNQKMVEFANRGFRALGLAMADGDGKDGTKWEMLALLPLFDPPRHDTKETIEHCQNQGIQVKMITGDHLLIGKETAKMLGMGTEMFPSEVMIKARNGDASQLHGYKNFVEMVETCNGFAQVFPEHKFEIVKILQDSNHVVGMTGDGVNDAPALKKADVGVAVADATDAARGAADIVLTEPGLSTIVTAVIGARKIFQRMTTYSKYTIAMTFRICFTFGLITVIYDWYFPTILIVIMAVFNDGAMIALSKDRVVASKTPNSWNITNIFIMGMVYGLYLTLSTWALYQTATKTTFFEDKTPLHSLNDQYSVLQPWCEDEVRAKLGQTIDPYASLCESNSYAKQFDECEGYQKGSGVQVEDVPTLHAQCVTEQRYLRGAMTRSLIYTQVSISGQALVFVVRTAGYSLMERAGTSTYLAFFFAQVGATLFGIFGLGGFEKPRHQLEDCQFCDYSFHEPVDWFDSGIVPESGTESDFTASVIGCGGYVIVAWIWSAIWYVLLDPIKWILFWILNEEGFRDTMSWRESTKRSLDRRSKDDIGDKEFTGPSGMVPANYSNPLGRASMSKPVSAVLDRKSASLVAINRNSMTVSQDPNRALNIGRRSMIGRPSGPVGRTSMPLGRISRTSNTLSTGSKDGQIGRGSKPLNSSSAEIKPDKYDFASTIRE", "function": "The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.", "AFDB_id": "AF-P54211-F1-model_v4" }, { "swissprot_id": "Q9SI03", "sequence": "MESPESFSTMFMKPIRHILSEKKSRKIALFLLINTAYMVVEFVAGFMSNSLGLISDACHMLFDCAALAIGLYASYISRLPANHQYNYGRGRFEVLSGYVNAVFLVLVGALIVLESIERILDPQEISTNSLLVVSVGGLLVNIVGLIFFHEEHHHAHGGSGIFLHVLADTMGSVGVVISTLLIKYKGWLVADPASSIFISILIIASVIPLLRNSAEILLQRVPRAHRQDLKEAMRNILKTKGVCSIQRLHVWSFTNSDVVATLHLLVSADSDKTDTKLQVSRLLEDAGVKDWTLQVESVNS", "function": "Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis.", "AFDB_id": "AF-Q9SI03-F1-model_v4" }, { "swissprot_id": "Q8CB14", "sequence": "MAKLNTKLRGCSQESSVSSLLASGSLSGSRSDSAHSAHSSFVYKDQLYSSASEALQAYIDDFDLSREHPGANAVKVNTDGEIGNGLQFSSYVHIPDNAFVNLDPKQHFNPLYYRRETVNDMDAISLTTDDLLRLPADGCFSFPCVPPDHRPNKKYSGRQDSSDIKNSPSFYVDATSKSKNNIVPPYVYTNINGKKCGRPRTPKPINRENKCVSESSLSFPKESSFTEDSAERRLENYPRWLTSQKSDLSVSGVTSIPDVKYPIWLHNQDLLPEANTPRGYKLLNEDEYRPIHSYQTQRANQLLNKIDCFEYTFKPSNLTDSFSEYEGLGNEFKCQCDNPLLPGQSQKPFCGDKIELLILKAKKNLKQSAKDLPKPVEKDDSPCSLDKLEAERTWENVPVAFKSPVPVKADDSPQQSSRTQCVNAFLEDFLNGENQSSTLSGGKHHGPVEALKQMLFNLQTVQESFNKNKTTEPEEEIKQVSEDDLAKLQMKENMMPITRSLHKALQHLSRLRDLVDDTSGRQSPKK", "function": "Might play a role in cell proliferation.", "AFDB_id": "AF-Q8CB14-F1-model_v4" }, { "swissprot_id": "B6UV92", "sequence": "MMSTTTTSSAAGSPVCARRRQRVFVDVPRRRATSLARVEYAKMAPPPPPPCSVRAAGSNPIGCLEVAEPWSGAAPPPLPPLPGHLHVAAPAAEDDDDALAAAAAAVPSEQRVHDVVLKQAALAAAAPEMRRPAQLAERERVAGGLNAAFDRCGEVCKEYAKTFYLATQLMTPERRRAIWAIYVWCRRTDELVDGPNASHMSALALDRWESRLDDIFAGRPYDMLDAALSHTVATFPVDIQPFRDMIEGMRLDLTKSRYRSFDELYLYCYYVAGTVGLMTVPVMGISPDSRANTETVYKGALALGLANQLTNILRDVGEDARRGRIYLPMDELEMAGLSEDDIFDGRVTDRWRCFMRDQITRARAFFRQAEEGASELNQESRWPVWASLLLYRQILDEIEANDYNNFTKRAYVPKAKKIVALPKAYYRSLMLPSSVRHCSSLTSS", "function": "Catalyzes the conversion of geranylgeranyl diphosphate to phytoene. Mediates the first committed step in carotenoid biosynthesis. May play a role in regulating carotenoid flux in response to abiotic stress in roots. May control flux to carotenoid precursors that are required for abiotic stress-induced abscisic acid (ABA) formation in roots.", "AFDB_id": "AF-B6UV92-F1-model_v4" }, { "swissprot_id": "P34283", "sequence": "MAHTSDGWGAPYDNQTYVEAYEQLEIALLEPLDRILETANVEEFRPKFKNHQDPNDRKNKKNNDEEWRDSIYNIATDESDTDDHEQRKNFFQPPLQVQRNSFVKNTLMEFKRSSQIDISRLAVMGCGEMSLEKGICEYLGSFGTINVLSVDIDEPSLSIGQQLLGKHLERNAEILAVETGLPVLMRSYVGDILEPDHRFADVDAIVSMEVVEHIPLPNAKKFVENVLGTLMPRIFIFSTPNHEYNAVFGMEPGEFRHGDHKFEMNRKEFSNWLEELSIRFPHYQIDPPHYIGMTRGYENLSGASQAAVCRLQVDLNTTLPQEVTPYEMVGHLPCRLGSRLIAYNLVKEAFLDWLEKIELQEHEPRTDGYSPYWIFNVQNILHHLKAPVSFALTIDEKVAIKYIQGMTSRKVHAEYSHGFNGIVILQMHSKEELIKTVQDNTL", "function": "Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when they are bound by argonaute protein ergo-1. This occurs in the female germline and embryo, but not in the male germline. Does not methylate 26G-siRNAs bound by argonaute proteins alg-3 or alg-4. Methylates and stabilizes 21U-piRNAs, which are a class of 21 nucleotide piRNAs that possess a uracil residue at the 5'-end, in the male and female germline. In addition, may play a role in exogenous RNAi (exoRNAi) pathways in the germline.", "AFDB_id": "AF-P34283-F1-model_v4" }, { "swissprot_id": "Q59VF4", "sequence": "MSSAKEQSSVTAALQPEQWTTSSNEALKLFVTNPEAALNFQPTFTYPIFGDAETIYGYKDLDIFLCFDHYTFKPFLNIKYSAKLTDDPEIIDIKKTIDEFLPKSTIFKDEVKWVDSIKEEKDNGYKIPGKLIDSFSENDKEYDIYKIDLKSDNGYELHQRLQILVLLFIEAGSFIDAKDELWNLYVLYEKDNKSTSNNEPSIVGFTTAYNYWKYPGAKKFDSTEQESRIKISQFIILPIYQGQGLGQLFYSHLFDKWLAQDDIIEVVVEDPNESFDDLRDRADLKRLNTSEQFDFKAVTPKVDKEWVEKTRRALKLEKRQFARLLEIILLYKLKHGYPGITKRDVRLFIKKRLYDKNKEGLATLDDNTKKDKLQTAYQALEDDYYRILGDLKLNIKRENDEEETDTVSKKQKV", "function": "Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.", "AFDB_id": "AF-Q59VF4-F1-model_v4" }, { "swissprot_id": "Q92358", "sequence": "MHLLTTTLISFEQNKVEYLTQIAIYTQTPVCTDSNCEHARFLKHSLIQVSIERIEYLYSIFPNIWQFALLCQGQNKESLIHMEEDASTNFKLRYYVLPWSRRLQGYQSITVQNGSHVPLVKRLEKWRIFVEC", "function": "Involved in chromosome segregation. During meiotic prophase, connects telomeres to the spindle pole body by forming a bridge between the telomere protein rap1 and the spindle pole body protein sad1.", "AFDB_id": "AF-Q92358-F1-model_v4" }, { "swissprot_id": "Q62158", "sequence": "MASGSVAECLQQETTCPVCLQYFVEPMMLDCGHNICCACLARCWGAAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEQDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNRLDHLRRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSGLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.", "AFDB_id": "AF-Q62158-F1-model_v4" }, { "swissprot_id": "B2X1Z3", "sequence": "MIKKNLFKDFSRFSFVQSSIKNNVRCHSKLKLVQPFFIKTKQERNKKFLSSYKFSEIQLITIDLASPEKIKEWAEKKLPNGKIFGQVTNPNTLHYKTLKPLKGGLFCERIFGPIKDFECACGIQKQKPFNRIISFQNKQFCSKCDIEYTWSDIRRYQLGYIQLVTPVTHLWYLKGMPSYIRSVLGAKKKHIEAIAYCSEIVTIDQAWKPNRLIPFPETISSVALSSKKRNTFVNKEIVNIQLTYNNFKKFNVNNTRSLYVSINKKLFKKQFSNNSYNCTCVDNEIQNPIFFLKYFNINFLKPQNLKELKVLYINPDFYKVENYPYKNQVKFEFYQKICRSFIKTSLNNHKPIYALNYLSHSFLNSKVKIFSHFEHIDIHTMYVFNEEILINRFSNLARLKKNGKSKKKIGYIHSKKIHININKHLLYFKNKKLKNLQLSNNLKLIIIISNNASLNYFKNWSNTFNCMNTLILKMQFVNKKLHFQYYRSFFNTHTIERVYFNFFSLDYLKNSNFFVNFSKLLALNLLKFMKSNLFNIFIIPIPTILDNFIFKLSLDSQFQRLLNSLSIQKQKVLNSNSVISKSNKIFKKQFFIKNFSLYDEAIEILWQRFWKFGYYFTSNNMNNKLCKIITKFNKNNNGLRSTLPSWLKLIKKLIKKTQIDKKSNQNLLNFRVNVIHTNTQNKFSLFVNLIKIYLKKVLFLFQIAPENIKNIYIKKSIFIFQELRNKNFKYRNFRTQIKKIVIKLFGLELLPWVLSQFIFTSKIFYQFQKSKFSFYHNSNFLTFSRRHSGRNLIKKIKESSFLNFQIGVNNINTIFHYKYSFNCLPSCHIPNYKCRQKFFIYKNKIENILKLKKFRLFFNIWLSRFLKNNISVLNVVVNLKLNNINSNNLQTLNLLFYQKKWLLKKKQIFYNYAMLKEFHSKLLIVGTLHDFSNFIKLIYSSSYKNETLINIFSIQIQPFYKFNFIQKIRKYLNSEYYNSFDSGRTKHYLRKFLNKDSDNLFFKQFNYVYYFILFSSIISTQTIERGSLTSLNNQQFFLNLLCFFKLAKKNIFKKYSWLTSIQKYFYSRQIIKYKKKQQQKSMLKFVKKKTFFNKFLDLINSFIYDYQKRLKLLKKHSIIQLILKKKMYIFYFLKKLQNKLINEIQKYYFYEFEKKKFINIEFNLNNFKNIVIFMNLKKKILFLNSVLFQSQTNFFNKHANLNIFNNSYNYMYIDFNNFLSIGQFWQILINIFKNKINKYYLLSRSLPFIISNDYVKIDPLIKKFHDDLKHQVCFNSFLIKLTFYNSTLLYPLQNIIKNNNKVLQTRQQYYKIIKSNNLFLTNYFKKIRGNFTELSIKKFENIHTIVSCIGYFGYQDILYHQIRELKKNDYFRNFYLKFIKHDLSNNFNEAIFSVISESRISYNDSIFWNNIYSLSNRYSWKSDIELNIFLCYMLSPETPSDILIPLYKQRIHSSNVLREEPPIAGGGIILKLLKELDLPEMKKIDIQLQTILKKIPNKLHEIEVLLKHNQTNLKLLKYYSLKRRTVIEIEKSILRKLKYIRRLNWVSAKPEYMIIRNLPVLPADLRPIFKIQQQLTASDLNRLYQKVIYRNDRLKRFLKNSTTSNSFEMLFAQRMLQEAVDNLIENGKDINSIETDSRGRPLKSLGELLKGKKGRFRQNLLGKRVDYSGRSVIVVGPKLKLHECGLPIEMAIELFLPFLIKEILKNKYALTVRSAKIYIKKHRIKITQLLRQVVKRQPILLNRAPTLHRLGIQAFLPKLVEGKAILLHPLVCSAFNADFDGDQMAVHVPITNEARIEAWKLVLSRNNLLSPATGEPILLPSQDMVLGCYYLTIENLQSLTQKKFRINRKILNQRNYIFSDFEKIFIAYQRNQINLHTNIWVIFNNTIESDSILQEPTEIQVLFSGQYIKVYSDYYQKFNRNGKIYNQVVRTTPGRILFNLMLNNCFN", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "AFDB_id": "AF-B2X1Z3-F1-model_v4" }, { "swissprot_id": "P9WJA4", "sequence": "MPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLFFRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI", "function": "Toxic component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Probably an endoribonuclease, neutralized by its cognate antitoxin HigA which also requires SecB-like chaperone MT2006 (AC Q7D7P7).", "AFDB_id": "AF-P9WJA4-F1-model_v4" }, { "swissprot_id": "Q05622", "sequence": "MRKRITSMITVISLTLCGTIGTYPHNANASAKEAFEDISKRSECTKVFDNDNGTYTAYSNTAPIHYLNNDEWKEIDNTLIEDSDDYYRNKDNSFNIYIPKEYSLGKNIKNPVIMNYDTFSLSTSITDIKMPDRPEEETFSEGVYADINNEVYTTIDNSAIAEGMKAALKKSASMATYHSIVEDIDLDIAVHNASVSESIIINKLESLPETITYSISVEDAIIKKTEDNRLQLIKDNEAVLILSPFTISDSSENVNVMQVEYDLTESEEGYEVTLYPAETVNRMSSPVMPLSLGSEYSYDRPFSTVYNSQASLHPSIIIIT", "function": "Hydrolyzes both carboxymethylcellulose and xylan. Probably has a role in hydrolyzing oligosaccharides derived from cellulose, which are transported across the cell wall.", "AFDB_id": "AF-Q05622-F1-model_v4" }, { "swissprot_id": "Q6BT42", "sequence": "MNEYYEPTLLFRQNAVKKYSPELSPVSSMSSLDLPKSNNSSSSWLLDNHNPKDTEILNKSCSLNRLNIKSNYWKIPDNDMSLTSMALSRQGDSNKSLLGISSANDDSNLFIYELDLAENYLTHNNTISLPNVHAMRWVPQMGNNELSLITGNSKGYAHLVSIPNSNEEGQSAEIVKRFNHRKHLKSINKDPSIASHTSTDITKLNFMDKSMDLLSLYDNNLFLWDINGCDSQVRPKPISISSIPGIVNFDPIPHSSNSVGICGQFGVSLFDTRQPKFSVPSSVMKQANKRKLGANVIRWSPNDDNVFAASHMDGVIRLWDIRKQDYFASLDGHQGKKIISIEWNKNDLFSGGRDGNIVHWDLTSDINEYPKPDITNCGLKEGLNSIKFNPVKNSVEKTINQRQCGTVLPASNTNIVDMCSVSLTSHNEEDVKVLSIDSSSFLGLHSKIFDAVKVNINSEKTYYTDDDISLLLAAQQSSLSTLVNDSTENVTKPLTISRMPTTKITHDVAPPAIPTPASVVPTTPNMSNDTLAEGPDEFVEVGDIIRLKEPKFSFSNYNDSVFSVDSNHDIKSSPSSTTSRGSFGESSSSISTNPTIVEASPISHKRDPSDIFNFKTDFDFGLGLNDYKFDESLVDRSFDRMLSLKTNATNYYSVYSS", "function": "Involved in cell wall metabolism and required for the separation of the mother and daughter cells.", "AFDB_id": "AF-Q6BT42-F1-model_v4" }, { "swissprot_id": "Q9M3K7", "sequence": "MDKSKRPFIKSKRSFRRRLPPIQSGDRIDYRNMSLISRFISEQGKILSRRVNRLTLKQQRLITSAIKQARILSLLPFLNNEKQFERTESTTRTANFRTKNK", "function": "Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.", "AFDB_id": "AF-Q9M3K7-F1-model_v4" }, { "swissprot_id": "T2KMH5", "sequence": "MKRRNFIQLSSLATIGMSLPSAGIVNACSSFPEQSLEFKNLTSELLKEWCDGMLKVQINNPSNLEEHGALRCPSCSHIHGRCMDAVYPFLYMADVSGDEKYIEAAKLVMIWAENNVSQENGAWTVIPNPKSWKGITIFGAIALAESLHYHSHILDDKTLKAWTNRLARAGQYIYDTFTIDFTNINYGGTAIYGLDIIGDVLGNGNFKEKSKKMAEEVQAFFTKNDYLLYGECKPEADKLSAKGLHGVDLGYNVEETLNSLVMYALKNDDQALLQIVTKSLNSHLEFMLPDGGWDNSWGNRMYKWTYWGSRTCDGSQPAFAMMAHINPAFGTAAVKNTELLKQCTANGLLHGGPHYISAGIPPCVHHTFTHAKPLAALLDHWKHLPEINKTTALPRVTANGIKHFKDLDVLLFSRGDWRGTVSAYDAEYHYKKDYRQATGGSLGILYHNKVGLLCAASMAVYNMVEPYNQQPQPGKDIALTPRIETFKEDQWYTNLYDLTANLEAIDTKEVINLASVVKLKNESRKMVSGTASEFHLTYSCAKEGLTIKVSTQQDILEPTAFVLPIASPEKEKVEFVNEHEIKISKPGGVVTIKANVPLKLKEYSGTRTFNMVPGLEALPIELFFETHIKELVLIVSVV", "function": "Broad-specificity lyase involved in ulvan degradation. Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall. It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable). Ulvan lyase catalyzes the endolytic cleavage of the glycosidic bond between Rha3S and the uronic acids GlcA or IduA, producing oligosaccharides that have unsaturated 4-deoxy-L-threo-hex-4-enopyranosiduronic acid (deltaUA) at the non-reducing end. This results eventually in the degradation of the ulvan polysaccharide into deltaUA-Rha3S disaccharides and deltaUA-Rha3S-Xyl-Rha3S tetrasaccharides. It is also able to degrade the glycosaminoglycans heparan sulfate and chondroitin sulfate. Not active against pectin, xanthan or alginate.", "AFDB_id": "AF-T2KMH5-F1-model_v4" }, { "swissprot_id": "P53577", "sequence": "MHNIVCIKQVPDSAQIRVHPVTNTIMRQGVPTIINPYDLFALEAALGLRDRFGGEITVLTMGPPSAEESLRKALTYGADRAVLLTDRCFAGSDTLATTYALATAIRKIGKEYGPANLIFTGKQTIDGDTAQVGPGIAKRLGVGQLTYVAKVRSVDVANETIEAERRSEGGVQVLHTRLPCLITMLEATNQIRRGAMADALRAARAKIVKWSAQDAGVEDISKCGLKGSPTVVKRVFAPPARAERAALVESAEQPAQALIDAIFLNQPKLETDLATLARDARSGLSGQC", "function": "May play a role in a redox process involved in nitrogen fixation.", "AFDB_id": "AF-P53577-F1-model_v4" }, { "swissprot_id": "P08970", "sequence": "MSASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDEGGLDKDNESHSGDEEAVSVTGETKTNEIREKPEKKEVSAKSEKKEIVGKAVDKDNSEEVVRENKKKPVGEQEKA", "function": "Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190.", "AFDB_id": "AF-P08970-F1-model_v4" }, { "swissprot_id": "Q874I5", "sequence": "MTDTDTTTTIYTHEEVAQHTTHDDLWVILNGKVYNISNYIDEHPGGEEVILDCAGTDATEAFDDIGHSDEAHEILEKLYIGNLKGAKIVEAKHAQSFSTEEDSGINFPLIAVGVFLAAFGVYYYKTNFA", "function": "Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.", "AFDB_id": "AF-Q874I5-F1-model_v4" }, { "swissprot_id": "Q9HAC7", "sequence": "MPSETHAMLATLARVAALRRTCLFSGRGGGRGLWTGRPQSDMNNIKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGYIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVFAEPQVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHTTHILKEVLRYDDRAIGELLSAGVVDQHETH", "function": "Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.", "AFDB_id": "AF-Q9HAC7-F1-model_v4" }, { "swissprot_id": "P52321", "sequence": "MCVSRRRNSGRPILRVRAPHLLRARPHRRSKLKHRRISRKRATLAGSAVVALVAAGFTFQTANASDDVPAFGAKTLSADAAGKLATTLDRDLGADAAGSYYDATAKTLVVNVVDEAGAEQVRQAGGKARIVENSLAELKSARGTLTEKATIPGTSWAVDPVSNKVLVTADSTVDGAAWKKLSAVVEGLGGKAELNRTAGEFTPLIAGGDAIWGSGSRCSLGFNVVKGGEPYFLTAGHCTESVTSWSDTQGGSEIGANEGSSFPENDYGLVKYTSDTAHPSEVNLYDGSTQAITQAGDATVGQAVTRSGSTTQVHDGEVTALDATVNYGNGDIVNGLIQTTVCAEPGDSGGALFAGDTALGLTSGGSGDCSSGGTTFFQPVPEALAAYGAEIG", "function": "Has a primary specificity for large aliphatic or aromatic amino acids.", "AFDB_id": "AF-P52321-F1-model_v4" }, { "swissprot_id": "Q6K9A2", "sequence": "MSSNFEANNNNNGEKQLVCVTGAGGFIGSWVVKELLIRGYHVRGTARDPADSKNAHLLELEGADERLSLCRADVLDAASLRAAFSGCHGVFHVASPVSNDPDLVPVAVEGTRNVINAAADMGVRRVVFTSSYGAVHMNPNRSPDAVLDETCWSDYEFCKQTDNLYCCAKMMAEMTATEEAAKRGLELAVVVPSMTMGPMLQQTLNFSTNHVARYLMGTKKSYPNAVAAYVDVRDVARAHVLVYERPEARGRYLCIGTVLHRAELLRMLRELFPRYPATAKCEDDGKPMAKPYKFSNQRLKDLGLEFTPLRKSLNEAVLCMQQKGHLPLIYPVPKRAYL", "function": "Involved in the latter stages of lignin biosynthesis. Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes. Probably involved in the formation of lignin in defense responses.", "AFDB_id": "AF-Q6K9A2-F1-model_v4" }, { "swissprot_id": "Q9Y7M6", "sequence": "MSAPSPFIKKLAANDRKTRDKALESLQRFLSQKKKFERLDFLKLWKGLFYCMWMADKPLYQQKLSDNLAALVPIVWIDNRILFQSTFWETMGREWTGIDILRTDKFYLLMRRFCAAAFRDIQTRSKTALLDKVVAEYNQMWMDGPFNTENLAFPNGILFHLADIWTEELRKVYPEDVPKADWYLPFDSTIKSSHNVVLRKTLPKRLDRVSEYTKDSQ", "function": "Required for 27S rRNA processing to 25S and 5.8S.", "AFDB_id": "AF-Q9Y7M6-F1-model_v4" }, { "swissprot_id": "Q45412", "sequence": "MKYSAPIRLNALSAIVSHHGVLVVIGMLLAVPMAFPLFPIAATYCAAILAILLPLGRLQHVLATASSIAFAWLLTLRNPSRGLVEAGLGDDALHYMNAFYEFQQNYCCSPLDVLKTGIRSAGGGEPIFWYLSYGVAKLFDTPLMVWAILIFISLMLVWIAIYRSTERFAYVVFVAYLSTITLYALQGSAIRQAVAVGLVMVALDLLIRRRLVWAACVGLLAAGTHSSAAALLLVCATVMLFLSKDYGMLARKASWLGQLGRLLVLLVLAVAAVAFGSAEFVMSKIQARLSENQTGSAWEFQLAVEAVLACLFAWLFRMKLPREEKLTYFLFVLLCASTSFFAPAVGARLFRYTYCFYIVYLCVFFFAREGESLGQKKTLASLLFLASLGWAFYIVDVRYQGLFVSGGVIDHFLAGPFF", "function": "Probably involved in polymerization and/or export of exopolysaccharide EPS I which functions as a virulence factor. May play a role in export of EPS I or its intermediates across the membranes.", "AFDB_id": "AF-Q45412-F1-model_v4" }, { "swissprot_id": "Q979L5", "sequence": "MMRDFVSEEKLKLLFEKYYRSTDIDPPALITKREVGFMTFEGEIIRHMHLSNKFELNNMLRTTVPRHVYSSAAYYKKPDEKKMPEKIWEGADLIFDLDSDHLPGAEKMTYEEMLNSIKEQTKRLVNKFLVSDLGISEKDIRIYFSGSRGYHVHVSSEDVYPLGSDARREITDYVSGNSLSISVIDKALKTGEKRPGGWIKDVISKLYELGINAEKISQKQIERAIDQVKSHNATMVDAPVTYDIHRLIRMPQSLHGKSGMMVKEVDLDKFDDFDPLSDAIPKIFLEGDYDINVHEKTRKLRLLDYKIDLPPGRNRVPQYVAIFLVSSGRADFL", "function": "Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.", "AFDB_id": "AF-Q979L5-F1-model_v4" }, { "swissprot_id": "P0AFZ1", "sequence": "MSETKNELEDLLEKAATEPAHRPAFFRTLLESTVWVPGTAAQGEAVVEDSALDLQHWEKEDGTSVIPFFTSLEALQQAVEDEQAFVVMPVRTLFEMTLGETLFLNAKLPTGKEFMPREISLLIGEEGNPLSSQEILEGGESLILSEVAEPPAQMIDSLTTLFKTIKPVKRAFICSIKENEEAQPNLLIGIEADGDIEEIIQATGSVATDTLPGDEPIDICQVKKGEKGISHFITEHIAPFYERRWGGFLRDFKQNRII", "function": "May be involved in the enhancement of serine-sensitivity.", "AFDB_id": "AF-P0AFZ1-F1-model_v4" }, { "swissprot_id": "P0CU88", "sequence": "MRHKCLLAMAVVASMAFYSVISTKNVTQVDTVQQENRRLRPRVEPTANELDKQSDVDTKLEADRRLGYPGESGFMLEGELEERGGFPWRTFFLGLFASVIEERGGFPWRTFFLGLFASVIGVSIISACYGIT", "function": "Secreted effector that inhibits stress-induced relocalization of the transcription factor NAC069 to the nucleus, thus affecting its broad role in abiotic and biotic stress responses.", "AFDB_id": "AF-P0CU88-F1-model_v4" }, { "swissprot_id": "Q6BSL1", "sequence": "MDRPGFSSPPFNDKKIVLSPPPIESKQYSFLQQHNANSGPPVGFQERQQSVGYNLQQEFETLTADLDLDLRNNKDMQQNVDAPLPTTQSGNVGRGMMPSTSQYGFGELGTGGSLQNALLTDAALSPNLPTASSHSALGSLLNNNGNGSFLPPLASIPNRPQSVNDFSNFFNRQQQQQQTIDRQQQQQATNFYSDLIVFCNWIETLNPRDNITMIDYLCNNLPLDILLTFKSKLDSHLTHYHNQSATSQPLHQQQNQPVSFGVLSPYQQQQNDILAEMENLNLDNSLSSDAGASLNQKSAPALQQPKPKLNSVRNHGSHLYAEQQTQRPRSADPNIHKYSPNYNLPQQQFERTKSPTSHLYEKTNFLQLAAANSNPPSVSQQKGANNSDDSVDLSAHAALKLGALATINSRVALDSNRKSHVHSAHGHQQPHSHYFPQQGASQHGPFSPASAYEESINRSANSSSVPILVQHNKSPPGLTRSKKSTEGLGQGANASSGSPQTTSTTSMPADISNPDLLNNIPAWLKLLRLHKYTDCLKDIYWKDLIEYDDLSLEKRGVKALGARRKLLKAFDAVKESS", "function": "RNA-binding protein involved in post-transcriptional regulation through transcript degradation.", "AFDB_id": "AF-Q6BSL1-F1-model_v4" }, { "swissprot_id": "Q9JZN9", "sequence": "MAQTTLKPIVLSILLINTPLLAQAHETEQSVDLETVSVVGKSRPRATSGLLHTSTASDKIISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGETGDMADFSPDHAIMVDTALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSGELGLRLSSGNLEKLTSGGINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQTGSIGLSWVGEKGFIGVAYSDRRDQYGLPAHSHEYDDCHADIIWQKSLINKRYLQLYPHLLTEEDIDYDNPGLSCGFHDDDNAHAHTHSGRPWIDLRNKRYELRAEWKQPFPGFEALRVHLNRNDYRHDEKAGDAVENFFNNQTQNARIELRHQPIGRLKGSWGVQYLQQKSSALSAISEAVKQPMLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIQYDKALIDRENYYNHPLPDLGAHRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKERSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSGADFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQDDQNAPRVPAARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEWNWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKF", "function": "Probable receptor, TonB-dependent.", "AFDB_id": "AF-Q9JZN9-F1-model_v4" }, { "swissprot_id": "O07085", "sequence": "MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRYDSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLKIKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAYGNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHASHTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNIIWATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGNDAEYIVKQMNGE", "function": "Involved in potassium and divalent cation transport. Enhances the transport activity of the cation/potassium transporter CzcD.", "AFDB_id": "AF-O07085-F1-model_v4" }, { "swissprot_id": "Q76PD3", "sequence": "MSVEVDKSSHSKPKIEKKSKRNKRKWLNDENKTHVTASEAAIERLKKSASFSQAAQQALKQSRKEDNERDIEMQDVDAEAQPHDLLPIPQPSVEDFVDSKPHVKNITSVLPKWLAEPITVDPNTTVEFSSLNISSKLVERLQKQNITRGFAVQAAVLPLLLQDGRHGPMYSYGGDVCVSAATGSGKTLSYVIPIVQCLSHRTVPRLRCVVIVPTRELTVQVAKTFEYYMSGAGLQVCAWTGQKSLRHETYQLNGDENECRIDVLVSTPGRLVDHIRNDESFSLQHLRYMVIDEADRLLDQSFQDWVDTVMMEISHPKCLQNKSNILDLDQNISPTFLPDIDTLLPYRLPSPLQKLVFSATLTRDPSKIASLKLHNPRLVLVQNKDMEVDDGGEIEDDAIVFSVPPTLQEYHVSVSSEKPILLYHLIHSKNLTNILCFVKSNEAAARLHRLLELIHESLNQSFSCGLFTSSLSRDERKKIISRFATGDLNLLVCSDLMARGIDVANTQNVINYDPPLSVRSYVHRIGRTARAGREGFAWTLVQSHEGHHFSKLVKQLRRTLPIKRIKIEFSHISEEFVVAYDKALEALRVEVFNSRYPQQKSFLT", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.", "AFDB_id": "AF-Q76PD3-F1-model_v4" }, { "swissprot_id": "P40349", "sequence": "MALPPVKIASRPASPTPSHHHQQAAAASSSSSSSSSHHPPPRIAARPIAPADRSPERVSQHSRGASVHDADSLPPIRPRGSRPSSPSGHAADRAPSSHHNASSTATVPARSTARSLFRDPRTLHPAGRSQSPIAAFRNRSQSSERSRLGPSRSQPNSPLLQSSSLRHHSDATGVHLPPISSLSKELVSDHPDCFAHRRRTPTTSPRATARLHMGNTFRDSSPAASSGSPATMRHDHLAYRHEHSAEEHAKMQRYSDEHPRAMNPTSRASYEHESRGMPYRDSYSAPSRAIEASYHANGARPVHHADSSTNSPQYVPGDVYEHEGSGSPPAAHHAGMRCSNCGVTSTPLWRRAPDGSTICNACGLYIKSHSTHRSASNRLSGSDASPPTHEAKLAAAGPSCSREDDPKSGSCPGDGLCNGTGGTASCSGCPAYNNNLSHALKVSKRESQTSEDPPPARTAERAPPVAEEKMDDDKSVVGALRCTNCQTTTTPLWRRDEDGNNICNACGLYHKLHGTHRPIGMKKSVIKRRKRIPANATAQPTHILDVIPVQMNANGQPVIAPAAGRNAGDSTPKSTESRRASKKSSLTSEQAMREARDREAAMLLMEVGAGARSRNSAQEDDRIHQNGALATSTSFHHDFHSARAGADTARTSHPDDSRSSKRPRQSYPLAPREAYDERDVSAIASPPAYNETHAAGATRSQRSQRSPVDAPLTDRLGRSELHGESSHGTSNAPEHAARASASDGARLGSVVPHHHHHHHHHHANHASHAVHHGHHHHHHHPVTVSASSHGHAGQAPSGMTKLSEVERLRDELLFERRRIDEVLRRAEAILASARAGNFHVEAAGPSTSGLRNGHEASHESPPTGSAQGSPGADARGTRSGHDSIKQEAPDAAPRRSKAFSNSSSSSEKDELESPPPSAHQQLASQPLVAATGAQPASRRNSFEQRMASLPVMAAVPLKRSSPPSTVSNPADNRPLSIAPQPARKATAWGIDTRSTPAASPRSGEKRARADEMDEDDDHWNWDNLYGKAKLEKAGDWRGFARPVEDRRSQSKSNGVTRRESSSTPIAARLPVASSPSQAVSAPRT", "function": "Involved in the regulation of secreted ferrichrome-type siderophores. Acts directly or indirectly to repress the biosynthesis of siderophores.", "AFDB_id": "AF-P40349-F1-model_v4" }, { "swissprot_id": "Q15847", "sequence": "MASKGLQDLKQQVEGTAQEAVSAAGAAAQQVVDQATEAGQKAMDQLAKTTQETIDKTANQASDTFSGIGKKFGLLK", "function": "Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.", "AFDB_id": "AF-Q15847-F1-model_v4" }, { "swissprot_id": "Q5SKN9", "sequence": "MEGERMNAFPSTMMDEELNLWDFLERAAALFGRKEVVSRLHTGEVHRTTYAEVYQRARRLMGGLRALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAEDKVLLFDPNLLPLVEAIRGELKTVQHFVVMDEKAPEGYLAYEEALGEEADPVRVPERAACGMAYTTGTTGLPKGVVYSHRALVLHSLAASLVDGTALSEKDVVLPVVPMFHVNAWCLPYAATLVGAKQVLPGPRLDPASLVELFDGEGVTFTAGVPTVWLALADYLESTGHRLKTLRRLVVGGSAAPRSLIARFERMGVEVRQGYGLTETSPVVVQNFVKSHLESLSEEEKLTLKAKTGLPIPLVRLRVADEEGRPVPKDGKALGEVQLKGPWITGGYYGNEEATRSALTPDGFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHPKWQERPLAVVVPRGEKPTPEELNEHLLKAGFAKWQLPDAYVFAEEIPRTSAGKFLKRALREQYKNYYGGA", "function": "Catalyzes the esterification of a number of long chain fatty acids with CoA, resulting in the formation of long-chain fatty acyl-CoA. Myristate (C14) is the most efficiently processed fatty acid, followed by palmitate (C16). Also catalyzes the esterification of stearate (C18) and laurate (C12), but at lower efficiency. Does not catalyze the esterification of the unsaturated fatty acids mysteroleic and palmitoleic acids in vitro.", "AFDB_id": "AF-Q5SKN9-F1-model_v4" }, { "swissprot_id": "Q9Z873", "sequence": "MDTIDTPGEQGSQSFGNSLGARFDLPRKEQDPSQALAVASYQNKTDSQVVEEHLDELISLADSCGISVLETRSWILKTPSASTYINVGKLEEIEEILKEFPSIGTLIIDEEITPSQQRNLEKRLGLVVLDRTELILEIFSSRALTAEANIQVQLAQARYLLPRLKRLWGHLSRQKSGGGSGGFVKGEGEKQIELDRRMVRERIHKLSAQLKAVIKQRAERRKVKSRRGIPTFALIGYTNSGKSTLLNLLTAADTYVEDKLFATLDPKTRKCVLPGGRHVLLTDTVGFIRKLPHTLVAAFKSTLEAAFHEDVLLHVVDASHPLALEHVQTTYDLFQELKIEKPRIITVLNKVDRLPQGSIPMKLRLLSPLPVLISAKTGEGIQNLLSLMTEIIQEKSLHVTLNFPYTEYGKFTELCDAGVVASSRYQEDFLVVEAYLPKELQKKFRPFISYVFPEDCGDDEGRGPVLESSFGD", "function": "GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP.", "AFDB_id": "AF-Q9Z873-F1-model_v4" }, { "swissprot_id": "A1T557", "sequence": "MRLRISEAVVLFLLGAVAALIGDHSHVVTGTTVYHTDAVPFVWSSPFWFPILVGAATASLAELRLHLPAPRDGVTARQALGGVAAVVGTYVTTALVHAFPVVPVTALVCAAAAITWCVLGDGPGAACGVVIAVIGPAVEIALVQLGVFAYHPDSDGLFGVAPFLAPLYFAFGVVAALLGELAVARRPQLGPPVCDTVSRGPGAG", "function": "Diacylglycerol-binding protein.", "AFDB_id": "AF-A1T557-F1-model_v4" }, { "swissprot_id": "Q8YLG0", "sequence": "MNEKLPISIAQITDIHLLASESQRLQGISTTESFLAVMKRLEELRPELDLLLMTGDLSDDGTPESYENLQHYLNSLQIATYWLPGNHDCAIAMDKILNLGMVSRRKSFQRGNWNFILLNSSVTDCVYGYLSATTLDWLDSELKMLPNNPTLIALHHPPLSVNSAWIDRSCLQNSQELFAVIDRYPQVKLVLFGHIHQEFRRQRHNVHYLGSPSTCYQFQSQSTTFAINQELPGFRLLKLYADGTWTTKIERVPYSLPIEPTVTVSY", "function": "Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Can also hydrolyze cGMP.", "AFDB_id": "AF-Q8YLG0-F1-model_v4" }, { "swissprot_id": "P09442", "sequence": "MAHFQNQYSAPEVTQTDAYGNPTRRTDEYGNPIPTQETGRGILGIGGHHHGGHHGLHRTGSSSSSSSSSEDEGTGKKKKGLKERLKEKIPGNKEHQSQATSTTTPGQGPTYHQHHREERSDGQDQGEAPWSPQPLISCLWSAISY", "function": "LEA protein are late embryogenesis abundant in higher plant seed embryos. There are two subsets of LEA proteins (5a, and 5b), the first ones are expressed when the cotyledon weight reach 80 mg and the second set are expressed above 100 mg. The function of those proteins is not known.", "AFDB_id": "AF-P09442-F1-model_v4" }, { "swissprot_id": "A5GQP4", "sequence": "MPAGHGQTAMTREQQPPRFTLNCWADAAMASTATTARPTVAFAHLGCEKNRVDTEHMLGLLAQAGYGVSADEADAQVVVVNTCSFIQDARAESVRTLVDLAEQGKQIVIAGCLAQHFQEELLESLPEARAIVGTGDYQHIVEVLEQVEAGERVNRVSQVPTFVADENLPRYRTTSEAVAYLKVAEGCDYRCAFCIIPKLRGDQRSRPIESIVAEAQQLAAQGVKELILISQITTNYGLDLYGKPQLAELLRALGEVEIPWIRVHYAYPTGLTPEVLAAYREVPNVLPYLDLPLQHSHPEVLRAMNRPWQEGVNGQLLQRIREQLPDAVLRTTFIVGYPGETEEQFEHLLEFVQEQRFDHVGVFCFSPEDGTPAADLPNAVPAEVAEARRGRLMEAQQAISAERNGAWVGRIVDVLVEQENPSSGELIGRCLRFAPDVDGEVRIRAGSHGAAASAGTMVPVRITAADIYDLEGEVVGAQEMVDAVRHS", "function": "Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.", "AFDB_id": "AF-A5GQP4-F1-model_v4" }, { "swissprot_id": "Q9UIQ6", "sequence": "MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL", "function": "Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.", "AFDB_id": "AF-Q9UIQ6-F1-model_v4" }, { "swissprot_id": "D2ZZC1", "sequence": "MQYGMDSFGLRGIPHQVFIKKKEGKIMSLAWWKRELFGGWTHFEAVWLLMFLGIQAVVFVFNPDSWLASVAAVTGILCVVFVGKGKISNYLFGLISVSLYAYVSYTFKLYGEMMLNLLVYVPVQFVGFAMWRKHMALGETAETEEVKAKALTVRQWLLVVAASVVGTSVYIEWLHHLGSALPTLDGVTVVVSIVAQVLMILRYREQWALWIVVNILTISLWAVAWFKNGETSLPLLLMYVMYLCNSVYGYINWTKLVKRHSGQ", "function": "Required for nicotinamide riboside transport across the inner membrane.", "AFDB_id": "AF-D2ZZC1-F1-model_v4" }, { "swissprot_id": "A0A482NB13", "sequence": "MASSEVFTSEEAAQRAIKTYYESQESRMGYELVFGGTQHFGYYTPGTWSPFPIDKSLRRMEEKLMGWLALPAGSRILEAGCGVGHVALYLAKHGMRVTGVDIIDHHVEQARRSAQKANLPKDQIVIEKMDFERLEAIPSASHDGAFTMQSLGHAFSAEKALAGFFRVLKPGGRFALVEVERRPNAEADKKNPRLTEQLSMINVGTGMPTNERSHDGFYKGLLEEAGFVDIESRDISDNILPVVRMFYVVLLVPYLFVRLLGIEKHFVSMLAGTAGYVGYDRWRFMVVTGRKP", "function": "S-adenosyl-l-methionine-dependent Diels-Alderase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain. IccD catalyzes the Diels-Alder reaction that converts the acyclic 2-pyridone intermediate to 8-epi-ilicicolin H. The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iccA with the partnering trans-enoyl reductase iccB since iccA lacks a designated enoylreductase (ER) domain. The cytochrome P450 monooxygenase iccC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone. The pericyclase iccD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H. Finally, the epimerase iccE converts 8-epi-ilicicolin H into ilicicolin H via epimerization. IccA to iccE are sufficient for ilicicolin H biosynthesis and the roles of the remaining enzymes, iccF, iccG and iccH within the pathway have still to be determined (Probable).", "AFDB_id": "AF-A0A482NB13-F1-model_v4" }, { "swissprot_id": "O58284", "sequence": "MKKGAVGIGTLIVFIAMVLVAAVAAAVLINTSGYLQQKSQATGRQTTQEVASGIKVTRVVGKADSATNPTYIQELAVYITPNAGSSGIDLTKVRITLSDGQKQAIFKYRVGNSANELYFLAELMQNLGATIKFDNGSVQVYFDPTDWTSAAPTVIIDTTNKVIEIVNATVDSNDNHIKPATDSNVTISFDTPVSLYAFANPVSDVFDNDAFNNLTTKTDFGIAVLQDSDGSLDNKEYPTLTKGDLVVLALRVGGTQSLGYSSGVSKISVISTTTTDVLTKQSSVNVTITWTAVFGNGFDTGTKVTGKVIPEFGAPGIIEFTTPSTYTQQVIELQ", "function": "Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.", "AFDB_id": "AF-O58284-F1-model_v4" }, { "swissprot_id": "Q42908", "sequence": "MGSTEFSWKLADHPKLPKGKTLAMVVLDGWGEASANQYNCIHVAETPTMDSLKQGAPEKWRLIRAHGKAVGLPTEDDMGNSEVGHNALGAGRIYAQGAKLVDLALESGKIYDGEGFNYIKESFETNTLHLIGLLSDGGVHSRLDQLQLLLKGSAERGAKRIRVHILTDGRDVLDGSSVGFVETLENDLAQLRAKGVDAQIASGGGRMYVTMDRYENDWSVVKRGWDAQVLGEAPYKFKNAVEAVKTLRQEPKANDQYLPPFVVVDESGKAVGPIVDGDAVVTLNFRADRMVMLAKALEYEDFDKFDRVRFPKIRYAGMLQYDGELKLPNRYLVSPPEIERTSGEYLVHNGVRTFACSETVKFGHVTFFWNGNRSGYFKPEMEEYVEIPSDSGITFNVQPKMKALEIAEKARDAILSGKFDQVRVNLPNSDMVGHTGDIEATVVACKAADEAVKMIIDAIEQVGGIYVITADHGNAEDMVKRDKKGQPAMDKNGNIQILTSHTLEPVPIAIGGPGLTPGVRFRNDIPTGGLANVAATVMNLHGFEAPSDYEPTLIEVVSN", "function": "Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.", "AFDB_id": "AF-Q42908-F1-model_v4" }, { "swissprot_id": "Q22744", "sequence": "MLRSVVNNNDKAKESEQSVRVATDDPTYQSYAFQPSTSSSNISWFGGLRTKLSQLSLFPDWMSQLGIKSDDEKMETSSTSSPQSEQSIGEYDESTLVFRPVQLDHFGGAGQEDDGEQVDIWDFGATFLADLDSNHVWNDTIERQHFGPLKDLITTGGGANKINNHSFKTHSLLHPTWCDKCGDFIWGILKEALKCEHCNYTCHARCRDLVTLDCRSPGSSLASSTEFDSIYPQLDGTLGTIPKGLILPPAMSSSTGSDKENGNGNSAGISAENPIFSVKNSFTLPKSFSPVDSLRTKEPSAPPESRYATLRVVERYVKEDTPFEWTDEYKEMDLERKIHSYNSLAKGMEITLHEDGVNFGGHIHVNMNLSRPISVVQGVIPPTVYDVVNTAKSTAKTTSLRTITSFFLPRNTAKVINIDSKTTARKMIVTLLKKFRVADNPRKFALYECEQITDEATCTLNRKLTRISDDACPLKVVLNWQSPHCGRALVLQENDTGDILWDAFEIPELENFLRILGMEEKQYVFQTQQKYQQYRYHLDAELRQRGHSVPDAAAQPMVQTNPFLDEEFLRNQDEYGTSDSMLFSGTIKNAIMGEDPDYVNLEYLKKQNMDQSTNL", "function": "Involved in embryonic morphogenesis. Plays a role in the organization of apical filamentous actin in epithelial cells of the developing embryo. May play a role in let-60-mediated vulval development. May induce nuclear condensation. Positively regulates the oxidative stress response, and this may be in association with the small GTPase rab-39. Not required for muscle integrity.", "AFDB_id": "AF-Q22744-F1-model_v4" }, { "swissprot_id": "Q9VCK2", "sequence": "MNKIFGLLFTLCLLLVWPTPGNGQSPDESRLLVAIHYEALCPDSMSFIRRRLYDALQDNDWWSVTDLKLYPFGKAGFYNNTSTGESQVFCQHGVDECELNALHACIIETLDIRKAFNLIYCMLRSYSNELGPCSRSMGVDVSKARECKASRTTAEILAPYGKETLKLGISFVPTIVFENDFDPYDQRSIRNNFERHFCRQYLKKFNIKLPTCSAIL", "function": "Involved in the immune response to bacterial infection.", "AFDB_id": "AF-Q9VCK2-F1-model_v4" }, { "swissprot_id": "P32718", "sequence": "MQKQHNVVAGVDMGATHIRFCLRTAEGETLHCEKKRTAEVIAPGLVSGIGEMIDEQLRRFNARCHGLVMGFPALVSKDKRTIISTPNLPLTAADLYDLADKLENTLNCPVEFSRDVNLQLSWDVVENRLTQQLVLAAYLGTGMGFAVWMNGAPWTGAHGVAGELGHIPLGDMTQHCACGNPGCLETNCSGMALRRWYEQQPRNYPLRDLFVHAENAPFVQSLLENAARAIATSINLFDPDAVILGGGVMDMPAFPRETLVAMTQKYLRRPLPHQVVRFIAASSSDFNGAQGAAILAHQRFLPQFCAKAP", "function": "Catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. Has also low level glucokinase activity in vitro.", "AFDB_id": "AF-P32718-F1-model_v4" }, { "swissprot_id": "P29072", "sequence": "MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRAAHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQSIIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEEQGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVCFLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQKQPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTETVERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDRTVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDGAGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDVVKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETAVIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAFVVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII", "function": "Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to CheB, CheY or CheV.", "AFDB_id": "AF-P29072-F1-model_v4" }, { "swissprot_id": "Q8RX71", "sequence": "MMHNSTEESEWEVRPGGMLVQRRDDAASSDHKPLQDPDSASAAFAQTIRITVSHGSSHHDLHISAHATFGDVKKALVQKTGLEASELKILFRGVERDDAEQLQAAGVKDASKLVVVVEDTNKRVEQQPPVVTKEMEKAIAAVNAVTGEVDKLSDRVVALEVAVNGGTQVAVREFDMAAELLMRQLLKLDGIEAEGDAKVQRKAEVRRIQNLQEAVDKLKARCSNPFVDQSKAAAVSTEWESFGNGVGSLNPPPPASPSANVTQDWEKFD", "function": "Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses.", "AFDB_id": "AF-Q8RX71-F1-model_v4" }, { "swissprot_id": "O67644", "sequence": "MPSLKISPSEAEKIQNYLVSSGFRKINAPYTLWALEGNGVKVYYYKTGSLLIQGKNSEKVLKEVLNLLEKKKLPGCDESGKGDIFGSLVLCCVCIPEENYLKVSSLNPRDTKRLSDKRVERLYLALKPLVKAYCYEIKPEEYNKLYRKFRNLNKMMTHFYKLLIERVKEECGVSEVVVDKYQPSNPFGEDVIFETEAERNLAVAVASIFARYKFLQSLKEVERELGIKIPKGTSKEVKELAKSLKNPERFIKLNFNV", "function": "Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.", "AFDB_id": "AF-O67644-F1-model_v4" }, { "swissprot_id": "Q99549", "sequence": "MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ", "function": "Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed.", "AFDB_id": "AF-Q99549-F1-model_v4" }, { "swissprot_id": "O80574", "sequence": "MATNGLMASSSVFLHRPRIAFASRTNQTVGKYGKGRVSFMGIGTRRLPVVLSMTAMADSGEEAVKSVLPGNGISIMVNGCSGKMGKAVIKAADSAGVNIVPISFGSAGEDGQRVEVCGKEITVHGPTEREKVLSSVFEKHPELIVVDYTIPSAVNDNAELYSKVGVPFVMGTTGGDRNKLYETVEEAKIYAVISPQMGKQVVAFLAAMEIMAEQFPGAFSGYSLDVMESHQASKLDASGTAKAVISCFQELGVSYDMDQIQLIRDPKQQVEMVGVPEEHISGHAFHLYHLTSPDETVSFEFQHNVCGRSIYAEGTVDAVLFLAKKIRLKADQRIYNMIDVLREGNMR", "function": "Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.", "AFDB_id": "AF-O80574-F1-model_v4" }, { "swissprot_id": "Q7SY48", "sequence": "MTSLAHQLKRLALPQNDSSLLGRKEVVSVLFDPKDAASMDRSTFHALGCTGLEELMGIDAAFSEFQETLFSQGSLTLERSVQSKEVNKKLDKSISLFLTRLSPYFLLKPALKCIEWLLHRFHIHLYNQDSLIACVLPYHETKVFVRVIQLFKIEDPTHKWHWLHGIQKPGVPLARGTLLTHCYKDLGFMDFVCSMVTNSVKAYSELTRDGNCPQLRVIFSFYASTIVSALDAVEKITNSIIAKLLPFVQLGLKSNLSDYTAATYMIVCQMAVKVVMEAQLVDSLSVQLSRSLGRTPQLIREGLSCIIILLQNQKKGVIGQKTYGYLCAVPTLVSTLQSISTVHDISPLLSYLLPHLIHSVMTQNDEQQNEGLSDSTGLLQSVFQNLQLSSNLENTAAKLLLEEYVVCGNELPSDGISALNQRIQPTVRLFESRYPCALDMALENHVKNVSSDNEKNLLHQFISLTLSCGKYQILPESETSLMLSLNHPLPSVRNMAVDYLKEILNSEHNSFDEAFLKDALLERIKDDSPEVVLSALKALQHHMGLMDVEDTVSSLISLLHRIKPSADWCPVLKEAVRVLDDPRIIEGNPDLKAYISWELLPFLVMTRAAPECVELQMTSAITETTLISQHPLTQGWAKVLKAVLAKTSESDLLGVANEMLTTTLIKNLANMDHATKRNTLENVCDILSRQGSSVRDRAAFVVFSSALLQSLQSMTESQHLHTAQSVYKLLEPLLLQAYTIQPEQVSDQPADECLPVCVALGEFLQKISCGLSAEQEQGLLLLSLLRLFITTLKCPDSTFKGEPWWNPEKMETTTCCYLRLLCRLFDVVISGASQGPLAPCFRSLMQPLLQVHLNEPMVLFKFLSLSWGYNSNLGDQLDCRVSAILQTQALYVGKAFLSSQPVKTLNLLASDSSPVVPSLLVCVCSGVCEVRRAAIAVLQCLSGLVSSPYHPLVEKLLKSSEEIIADSSYLTQALSKFYEEAVSRKDKNKKLASVEQLLQCLQSPFCPSYTSKTLLRALQDVHGEPVLSVLLPAVERLLEQCAPDSCTFLPDEALLLQLLLSKFSEMSAPLLVKDPRCLEVFIRALHTSARPYPTIPSFQITALEQITKPFFTAIGDEKIQQKILSILFDLLVGNKSPACAQSINSVFKTIAVDCELVANELIPADKQRVTATVQQTRRSKMRKTQDTSGAVPEESVVSWPRVTLILELLQHKKKLKRAQYLVPALFNLLSRCLEPAAAEQENIEYTKQLILICLLNVCQKLSPEGGPISKDVLEEDKFNMELVVQCVRVSEMPQTHHHALLLLGALAGIFPEKVLHNIMPIFTFMGANIMRLDDTYSFQVINKTVQAVIPALIKAHEGGSSQSEGHMETVVAQIIHVFVDALPHVPEHRRLPILSQLMSTLGPSRFLWVLMLLLFKQHVTQTSAGATGAEKEAVVERDQDFWILVCCEFEVKEQLTSLIKILQYLMTLPQDREEAPEKKKPRGRSAVKKDETVSDLIFSVETHSGKDLRHFKFISISFMAQLLASDGFVGKVADCEDITESTLQALQQDLLVEVLRYIQAVARCVEDNADKPTAKFWRALLSKSYDTLDKVNALLPMDTFITVMRGLVGNQLASVRRKAMELLNNKLQQRTKWLKEQITALLELIGTLLSIVGRSHRQVTAQEEEELAINRQTALYSLKLLCRNFGSDHKEEFVPVLNKAVELVADKDEEKNVMGSALLCVAEVTSTLKALAIPQLHRLMPAVLDTLKERKDLLNNEIYLLSAVTALQRASETLPHFISPYLLDTILQVTRLTLLARRLTSCPQLSVRLASLSSTLATKLPPRVLIPTITKCYCSMVDAQQNRLSPLMNILKEHISHMDKDQLNNHQSELTSFFLSALDFRAQHCQGDLKKTAEIEGCVIDCLLVMIMKLSEVTFRPLFFKLFDWSKIDGASKDRLLTFYRLADRIADKLKGLFVLFAGQLVKPFSDLLHQLNISHTDKAFFDSEDESDDDSDEEADDNVTKSSLLLQYVLDCLHKIFLYDTQHFLSKERADALLCPLVDQLENMLGGEETYKSRITTHLVPCIAQFAVAMRDDSQWKVLNYQILLKTRHSSPKVRFSALVMLLELAGKLRENYMVLLPETIPFLAELMEDECEEVEHQVQKVIQEMETILGEPLQSYF", "function": "Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Required for cell survival in the CNS through its role in rRNA synthesis and processing.", "AFDB_id": "AF-Q7SY48-F1-model_v4" }, { "swissprot_id": "Q05527", "sequence": "MRRYFIDDETPWEELGDGIKRKIITWSDDLMMVCVHFAKGAIGTPHKHDIHDQIAYVAAGSFEVVIEGEKRILKTGDAYMAVKNEMHGVVSLEEGSVLIDTFSPKRADFL", "function": "May have a role in pathogenicity.", "AFDB_id": "AF-Q05527-F1-model_v4" }, { "swissprot_id": "Q8VZN1", "sequence": "MMRWGRKKPVSSSSSSGLSRALPVSWFSKLSGSSDLKPAKEKKQDEKASQNISVKTSLSSTTRRSDIHENSKRFQRVSVEKENSATRSADKESNEKFEEIMSSVRKKVRDFQKETCGFLEVEAMDRDNGTVILTPRIQVNRDKQRCERRDQRLLEQKPKRSEQDAGVKVKKPARRTGTGGYSREDSVILGHTITKPAHQWEKLKEVKLREVKLKADQQRKSLYLKRELNRIGTKENNKVRVFSPRASEKCRVKAIEDLKKAKQRAREHELLIETADGGMENESFAVVKCSSDPQKDFRDSMIEMIMENGINHPEELKELLVCYLRLNTDEYHDMIISVFQQVHNDFNFH", "function": "Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors. Required for embryo development.", "AFDB_id": "AF-Q8VZN1-F1-model_v4" }, { "swissprot_id": "B0R6D7", "sequence": "MVVTVRAPATSANLGSGFDVFGVALSKPADVVRVERADTTTITVTGAGAQYVPTDPQENTAGVVAAALDAPATIHINKGVRPSSGLGSSAASAAAATVALAELYDRPLDDDALVRAAAQGEAAASGVAHADNVAPAILGGFTIVREDGIEHVDASLALAVCLPETTVSTRDARGVVPESAAMEAVVSTVESAATLTLGMCENDPQRVGRGVEDALVTPARARLMDGYEAASAAARDAGATGVTISGSGPGVVAVCRRRDRKRVAAALVDGFDSAGVAASAYQTRIGDGATRLAADGDDRAP", "function": "Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.", "AFDB_id": "AF-B0R6D7-F1-model_v4" }, { "swissprot_id": "Q15643", "sequence": "MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVNPFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ", "function": "Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.", "AFDB_id": "AF-Q15643-F1-model_v4" }, { "swissprot_id": "Q86H49", "sequence": "MNNLSKNDFLKLYRNILRCHKILQEPMRSMGDQYVKTEWKLHKKATPKQAIQFYEQWNIYCNILLTQRDSILKENSNNNDNYNNNNNDNNNDNNNFINIGQDLNEKQMKSLNKKQIEQLDKLKSETSTVYTPSDK", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.", "AFDB_id": "AF-Q86H49-F1-model_v4" }, { "swissprot_id": "Q2SBD7", "sequence": "MNHAVTIKSFVSTSPLSDLERGAVDKSKVAESFSAAAATYDLLAGMQKEVGESLVSLSREGCPQDIIDVGCGTGWLTHRLKNSFPEARLCAYDLSPGMIEYALAHHDNVAEIWAVADMESLPVANASQDLVFSNMAMQWLDDPRAWFAEASRVLRPGGRLICSTLLTQTLFELEQAWHGVDGGRHVNRFLSAEQVAEAAVSCGLRGECRESLYVRFHDSALDVMKELKGIGAHNIQSERPQGLTGKRRLRRVIENYEKCRQEQGVPATYHVGVCVYSRI", "function": "Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.", "AFDB_id": "AF-Q2SBD7-F1-model_v4" }, { "swissprot_id": "P53111", "sequence": "MTTDTTVFVSGATGFIALHIMNDLLKAGYTVIGSGRSQEKNDGLLKKFNNNPKLSMEIVEDIAAPNAFDEVFKKHGKEIKIVLHTASPFHFETTNFEKDLLTPAVNGTKSILEAIKKYAADTVEKVIVTSSTAALVTPTDMNKGDLVITEESWNKDTWDSCQANAVAAYCGSKKFAEKTAWEFLKENKSSVKFTLSTINPGFVFGPQMFADSLKHGINTSSGIVSELIHSKVGGEFYNYCGPFIDVRDVSKAHLVAIEKPECTGQRLVLSEGLFCCQEIVDILNEEFPQLKGKIATGEPATGPSFLEKNSCKFDNSKTKKLLGFQFYNLKDCIVDTAAQMLEVQNEA", "function": "NADPH-dependent aldehyde reductase involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Reduces commonly detected inhibitors in biomass conversion hydrolysates such as furfural, 5-hydroxymethylfurfural (HMF), cinnamic aldehyde, benzaldehyde, phenylacetaldehyde, and anisaldehyde.", "AFDB_id": "AF-P53111-F1-model_v4" }, { "swissprot_id": "Q93NF6", "sequence": "MGDTDLPCVTGVLLAAGAGKRLGRGPKALLPYRGRTLVEDAAETMLVGGCHEVVIVLGANAQAVCARANLEPYRIVVNHDWSSGMGSSYLAGDAAAHTKNHILVALVDQPGLSVTTVGRLLVSHRPGRISSAAYSSLDSPRVLRRGHPMVIDAGLRPAVASTVSGDAGARVFLRQKPWLVDLIDCSDESTGEDVDTVEQMYRLL", "function": "Catalyzes the reduction of nicotine blue to its hydroquinone form. Nicotine blue is the name given to the compound formed by the autocatalytic condensation of two molecules of 2,3,6-trihydroxypyridine, an intermediate in the nicotine degradation pathway. May play a role in preventing the intracellular formation of nicotine blue semiquinone radicals, which by redox cycling would lead to the formation of toxic reactive oxygen species. Besides nicotine blue, several other quinones are reduced by nboR.", "AFDB_id": "AF-Q93NF6-F1-model_v4" }, { "swissprot_id": "Q46494", "sequence": "MESKIRNYYAVKVTGGQEVSVGLMLEERAKTNNIPEIYSIIVPPGLKGYVIVEASGPHVVKLLIAGIRHVRGIAQGLVPKDHIVKMVSKKVTGPTIKEGDLVEVVSGPFRGMQAQVVKVTEGKGEVVLNILESAFPLQVTIPVDQVKPVKKT", "function": "Stimulates transcription elongation.", "AFDB_id": "AF-Q46494-F1-model_v4" }, { "swissprot_id": "Q9LUB6", "sequence": "MSSEKRVGMVEKSNNKRQRVNQVPVFSINDHHDVLVEILRRLDGSSLCSAACVCRLWSAVARNDSIWEELCFRQVSPRPSLSLRSVVSALGGYRCLYFLCIRPVLARLPKLLWTRDQLQLSLSLYCVHYYERLYVGAWLGDAPPSSLIFLRKPVNVV", "function": "Essential component of a SCF-type E3 ligase complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, such complex probably mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to activate the pathway. Can partially complement the absence of GID2/SLY1.", "AFDB_id": "AF-Q9LUB6-F1-model_v4" }, { "swissprot_id": "O51595", "sequence": "MYSMGGFVFLLQEFSGNSSFLRSLLVFVPVIAIFWFLVISPQRKEEKNKKEMIKNLKKGDKVLTIGGIFGVVKKLGDTDVILELSPNNEAVFIKNSIDKVLSEKK", "function": "The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.", "AFDB_id": "AF-O51595-F1-model_v4" }, { "swissprot_id": "Q5JJ73", "sequence": "MLDPFGKRAESLIREEFGDLLALLERVPSAISVEEPISLVSWMLESENPPQELVEVDNLEELRDLFKFYALLGAASISPYGLEAEVVKRATLRLYSERIKASKNLSETMLPVVPVGENEIPHNDLNILERRMDRNLSPEEKEKLKIKYKIPIKDLLNLWGSSLKEVYIRNGYAYLRWETALKMWEKAFEKRFERAVNILYEYRDELPEFYHRLREKLEEIAEEYFKERGEMFKGTASPLRFDLFPPCVKEALKGVPAGMRNYAITVLLTSFLSYARICPNPPKKDVRIKDCINDLKIIEEEILPVIIEAGNRCKPPLFEDQPHEIKNIWYHLGFGLTDSPTMEDSGNSTWYFPPNCDKIRANAPQLCKPDKYCRGIKNPLSYYLKRLYLEGKKKEGETSE", "function": "Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.", "AFDB_id": "AF-Q5JJ73-F1-model_v4" }, { "swissprot_id": "P22648", "sequence": "MRTVACAVLLACFMGCLAGAWAQSAGLEILPNSENQTKPIGRSMLLTCKPNVTNKNLISQLRWTDPSGREVPFKNPTLLKPHIFVDWLPPPGEKVLTLMIPELREADTGTYTCSALYSNTKQLSKSVHVRTIMPITWDDAPEEQYPTVNETFKIRCRVSANPPAIVNWMRDGHIVETGDRYVVEQDGLTILNVTEMDDGTYTCRAIVIATGEMALRPIRVEVHTPPQMSGALPPKLEAVEGTDFTAKCAASGKPVPRYTWIRVDTARDLTKDGDRVSADVLLGELRIREVRPEDAANYSCTAKNAAGTATATVEVTVVVRPRIGRFDNISVASGKDSEAVLECHATGSPLPAVTFRKLSNPNRYINGIQPTEDRITVDGVDSPDGRTRIGKLIISNVLRSDDGLYECIATNKGGEVKKNGHLMVEFKPSFADTPQKEVWGWEQHAVNLTCLAHSIPNATISWHFNGADLFRGREGQELQQTGYTLFGSGPRSTLQVIPFNRKMYGNYKCTATNKHGTAVHEIMLREARVPSAVLQVKMDVMTATTVTFKFFGPGNDGGLPTKNYAVQYKQDSQGWEDALNRTWPVDSPYILENLKPQTRYNFRFAAQNEVGFGPWSSQQTHTTPRISAPEEPRLLGLPLSATSGTENEVVVSPYPNRYELRWQVPADNGEPITHYSVKSCPVEKYDTEWRLLPYPCQEHKLEGQATTFQLESLQPDTHYKVEVRATNAIGNSVPGQIIVRTVKDPSQMPGVANVEDGSEGQMSSAAIVVLVVAALLLALLVVDLVCCLVWRGGLIAALCHRCCSAAKTDDSDAKIASLYSWRFPLPYCSNKEDPAMLAPAKMQQATVKIPVIEEKEPLRDGKEPVPIIKERVKRETAVDFDVKKSVSRTSFVGKDSAV", "function": "Neuronal recognition molecule. Involved in a pathway recognition for axons during the development of nerve fascicles.", "AFDB_id": "AF-P22648-F1-model_v4" }, { "swissprot_id": "O84955", "sequence": "MIIRFLALLFSAVVLVSLGHAQEKTHESSNWGKYFSDFNAKGTIVVVDERTNGNSTSVYNESRAQQRYSPASTFKIPHTLFALDAGAVRDEFHVFRWDGAKRSFAGHNQDQNLRSAMRNSTVWVYQLFAKEIGENKARSYLEKLNYGNADPSTKSGDYWIDGNLAISANEQISILKKLYRNELPFRVEHQRLVKDLMIVEAKRDWILRAKTGWDGQMGWWVGWVEWPTGPVFFALNIDTPNRMEDLHKREAIARAILQSVNALPPN", "function": "This is an oxacillin-hydrolyzing beta-lactamase.", "AFDB_id": "AF-O84955-F1-model_v4" }, { "swissprot_id": "A0A178VBJ0", "sequence": "MGCCQSRIDSKEIVSRCKARKRYLKHLVKARQTLSVSHALYLRSLRAVGSSLVHFSSKETPLHLHHNPPSPSPPPPPPPRPPPPPLSPGSETTTWTTTTTSSVLPPPPPPPPPPPPPSSTWDFWDPFIPPPPSSSEEEWEEETTTATRTATGTGSDAAVTTAPTTATPQASSVVSGFSKDTMTTTTTGSELAVVVSRNGKDLMEIIKEVDEYFLKAADSGAPLSSLLEISTSITDFSGHSKSGKMYSSSNYECNLNPTSFWTRGFAPSKLSEYRNAGGVIGGNCIVGSHSSTVDRLYAWEKKLYQEVKYAESIKMDHEKKVEQVRRLEMKRAEYVKTEKAKKDVEKLESQLSVSSQAIQSASNEIIKLRETELYPQLVELVKGLMCMWRSMYESHQVQTHIVQQLKYLNTIPSTEPTSELHRQSTLQLELEVQQWHHSFCNLVKAQRDYIQSLTGWLRLSLFQFSKNPLVRSSYESKIYSFCEEWHLAIDRIPDKVASEGIKSFLTAVHGIVAQQADEHKQKKRTESMLKDFEKKSASLRALESKYSPYSVPESRKKNPVIEKRVKVEMLKGKAEEEKSKHEKSVSVTRAMTLNNLQMGFPHVFQAMVGFSSVCMQAFESVYNQAKSIGEDQEEVKRLLP", "function": "Required for the coordination of cell differentiation and cell elongation in the root tip. Required for the coordination of cell processes necessary for correct root growth in response to phosphate starvation, through the modulation of the auxin transporter protein PIN7.", "AFDB_id": "AF-A0A178VBJ0-F1-model_v4" }, { "swissprot_id": "P08659", "sequence": "MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVNITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMNISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKSKL", "function": "Produces green light with a wavelength of 562 nm.", "AFDB_id": "AF-P08659-F1-model_v4" }, { "swissprot_id": "P53129", "sequence": "MNLNESYLDAEIPKGQLKHSKSGNFEGIPIVATTSEPTTSVNLDETFFKKAPIAMPICDDHSVSKSTSVNSLNTTSLASRRSPLQTKKLQAKNNLLSADLAKSNDDTTRALNSPKKDFGPYLDSENDIRSRLAESIYSMETSIRGSELQRRPYVSNEIPNVFKFSKFNSNCKLNESQTLCDKNFFIFTSAGKPIYCMHGKDEQIMSYTGLVNTVISYFQVNGPSELKTISTLTSGKRLTFLDKSPILLMAQSERGESSNELLNQLDFLYSYILSSLSERQLLRLFSKRENFDLRNYLESTDFENLDEICSLICNRMFPDLLLNSLQCLPFNHSSRLKLQNVVLQQLEKRQDIPRGTLLYGLIIAPQNKLCCVLRPRGHTLHTTDLHLLFCLISHQFQNLDETQELWVPICFPKFNSSGFLYCYIKFLPNDTHSNEKSALVLISAQKDAFFSLKSFSDELIIKLEEEKLLKKINTSKGFKLSDIPAPMVHHFIYKSKQNVQYVMPHFEVNSNIALDSSQGLEYELKLKTYYQQLHGTVVRDNGNLLSRSMLNFVRWSSKDNEDLAMDETQMDFSELDEYIIGNSSFKQESVNMVGMAWVTPTFELYLIGNNGIVDKRVLFKSARKVANWCQKHESRLFISDGAVF", "function": "In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking. The CCZ1-MON1 complex acts as a guanine nucleotide-exchange factor (GEF) for Rab-type GTPase YPT7, promoting nucleotide exchange on YPT7 and triggering endosomal maturation by activating YPT7 on late endosomes.", "AFDB_id": "AF-P53129-F1-model_v4" }, { "swissprot_id": "P50464", "sequence": "MDSDHNHINGDLAHGFENMVCVRCNDGFSMQDQMVNSSGQVWHSECFVCAQCFEPFPDGIYFEYEGRKYCEHDFHVLFSPCCGKCNEFIVGRVIKAMNASWHPGCFCCEICNKQLADVGFLRNAGRALCRECNEREKAAGHGRYVCHKCHAMIDDGQHIKFRGDSFHPYHFKCKRCNNELTTASREVNGELYCLRCHDTMGIPICGACHRPIEERVIAALGKHWHVEHFVCSVCEKPFLGHRHYERKGLPYCEQHFHKLFGNLCFKCGDPCCGEVFQALQKTWCVKCFSCSFCDKKLDQKTKFYEFDMKPTCKRCYDRFPTELKKRISESLKDRDVENQRRSMSPGPK", "function": "Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.", "AFDB_id": "AF-P50464-F1-model_v4" }, { "swissprot_id": "Q10437", "sequence": "MQTMSSGIARPVLFLTAREGEYVLKDEFQLGSSSRSTPQITGSPLDPNTPVKRLFFMRINIAQFSRWDYPYPREYIEELKKIHGVHHVEENRDVPSILENYRNSKRKSHNFSSSNTPYLKLHRPASRAGAPLINAKSFISSLTFHDNIVRSFQPSIHGKTFVFANHEKSFYWLDVSAANSHSALLKMEFPRASPVCHDINSFTKSPKGLDVIIGFDTGDVLWYDPINFKYLRFNKNGQLNSSSVTAIKWVAGKDSQFLVSFRNGWLVLYDKYRHEQPLHIVVPEKNLKSLYLSSPGTFNILISINHRDDRKLNPVACYAFSKSPINGFCFSPDYQYLALVSERGTLKLFDFVKEHVLDVFHSYFAGLTCVTWSPDGKFIAIGGKDDLVSIYSFPLRKLVARCQGHKSWVTDVIFDAWRCDDDNYRIASVGLDRKLLLWDFSVSAIHRPKSAVYYVNHHSNNSKPAISDFDDVGDLTMGSEIDNSNYVNGDITIHPTLSRSLIPVISPITIYDVDDSPLSSVFFDPDCMITCATNGRIRTWQRP", "function": "Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations.", "AFDB_id": "AF-Q10437-F1-model_v4" }, { "swissprot_id": "Q8IUX7", "sequence": "MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPEFGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFTTVETYTVNFGDF", "function": "May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.", "AFDB_id": "AF-Q8IUX7-F1-model_v4" }, { "swissprot_id": "Q6VE93", "sequence": "MGNVCVGGSRMSHQVYSPDRADTPPRSERNTPDRRQRAAGDAERTQSMRLQQKINDLKPYVRHARGPIKAYGQAALDRASGKKTSVSFAELDATHLDAMVYIENQRNPGLNLKHFRDHKELIQALQSDGPSAFRAIFPQTCPETGQTLKHHVMADVRLHQGGAPTIIITEPAVIVGARYQQLQRHNLTLEDLSESGVPLSQVAIIETQAQKTSDDCVMYSLNYAIKAHKNAAQFDDIHHGLQHGTLSTESESRARTTLGALEASSSYSVMHEGAHAAFGADVLPVDFYKHGASLTQAKQLMKRPDGRMAGRVNSEGHSEAENLVQRNQAFRVKRRELLDDETPSNTQFSASIDGFRLQEIKRVLAEEQR", "function": "Serine/threonine-protein acetyltransferase translocated into infected cells, which impairs host microtubule network and host immunity by mediating acetylation of target proteins. Blocks secretion in host cells by mediating acetylation of host tubulin, thereby impairing host microbubule network. Impairs host cell immunity by mediating acetylation of host TIFY/JAZ transcription repressors (Arabidopsis thaliana TIFY10B/JAZ2, TIFY11A/JAZ5, TIFY11B/JAZ6, TIFY5A/JAZ8, TIFY9/JAZ10 and TIFY3B/JAZ12), thereby activating host jasmonate signaling.", "AFDB_id": "AF-Q6VE93-F1-model_v4" }, { "swissprot_id": "A0A0U2WFX7", "sequence": "MRFAGMSCDDERPANMFDLMAPQLASTSCNEHYFSTADLGASTLYATTTDAPATIAGILTPQPATLAPMYSTCPVRFDDQRSAPASTSVSGKRKHSDVEKDRRRSISNGFAVLQNVLHNESNAKPISKSILLQQACDEIRELRKKLDASTTIISRFGLENLFVPTPSSTHASPPNASSRIYSPINQASDVLADTRRASISTSATPILYSEEKRKANAKRRHSYDGSWQASDRGSIDDEASASASASASASSSASCSSSSHTHSDDTDCDDTDTDIPAESALKERTKRHKARSKKERDRTKPRYRPKPSTNRSPTPSSCASSTPNSPPTSSNRNRDLQQAILSLLLELPSHLEDVKNKRRASQPTELADPSSVKSRSKKRHR", "function": "Transcription factor that specifically regulates the expression of the gene cluster that mediates the biosynthesis of itaconic acid and 2-hydroxyparaconate.", "AFDB_id": "AF-A0A0U2WFX7-F1-model_v4" }, { "swissprot_id": "Q18066", "sequence": "MASLAPFFKISDSILADESFDDLEINNHFKCTSKDLNEYPRTSTPLPGEITSIYSLPRSYNNQNLCTRSKPTTFISQNQQKGMTEKPKHSEYFLRLMKTRQEMQKKLTAKNGSNKSVQQYLRKLPPSTSKEVTIIPVKMKPDDNSVYISKELSDRTDTKLPKVSTKEVEKFGEQSDDEERHERSHIASDFNQKTPQSTHATSNHRKRIFIGRTGAKQQHVSKKATESELPYNIDVSTSNTTNATEALKLLKRPLLLPSKDPRSSKMPRLDLNQHQFRCKQYIVHSQFTCTQIEKTFKCRVGTSTESEDLDDYYFDAMPDGKAPHFPQQPVARQNDDGSLELECFVDANPTPQVKWYYDNKEVENSGRFSANLANKGSDSYSAILTIKELADADAGAYRCAIVNPHGKGNANFNLKLTGFSSPTFVEKPQISSRDDGQVMVMEFRAKSILEPTFVWQKLVGGGAEEIIANSDRIKAVKKLEAGNVYYSALEIKEPTKDKDAGQFICTVKNESGKLTATFTVKFEVPEGAPSFTRKPQILQQTSAGGEPAICFDIGYSARMNPQVTWISPKSKKMKESSRIKFKTNDEGNGNFTAQLELTNYKAKDSGTYTCNIKNDAGEANVELTLNIEGPLDDYADDSEN", "function": "Stabilizes the attachment of the myofilament lattice to the muscle cell membrane. Isoform b is sufficient for wild-type function.", "AFDB_id": "AF-Q18066-F1-model_v4" }, { "swissprot_id": "D8JBB8", "sequence": "MTRLTVEDLNQADKERFVDAVGDVYEESPWVAKRTWSEQPFSSIDGLQQAMANTVQDASQQKQLELLRAHPDLGERTEMTDESQEEQASAGLDRLPPAQYETFQTLNDTYRDKFGFPFIMAVKDESVGTIQQAMEDRIDHSRSKEFQTALNEVNVIAALRLEELTVPRDGTQEQHA", "function": "Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.", "AFDB_id": "AF-D8JBB8-F1-model_v4" }, { "swissprot_id": "Q9SSC1", "sequence": "MAGLQRSTISFRRQGSSGIVWDDRLIAELSQQAANDRKGETLQQDEQAKLITSEVQDQTTKPIAGEGLKPIRTDGGMERSRSNGGGAIRHHRNTGRVSPAVDPPSPRLSAFGCCSAFGKKQPGKKVNQRKRPAKRRSR", "function": "May play a role in the regulation of stomata patterning.", "AFDB_id": "AF-Q9SSC1-F1-model_v4" }, { "swissprot_id": "Q55CB6", "sequence": "MITSNNNNKNNNKKDVEMKSNEEEGDEIFFSILSGDTNNLFKFLNNNNSNNNNNNNNNNINNSIDIYLPYIIVGILEKNKDLLDEDENLKKLFYSPIYSKSIHNINQYQSLNFDHINEFIKDQVRIRKKLNHVNQDKKDTYLDNIDNPKYQFENGDKEVKMKLVLSDIIALLEFSEMQQSLTISKETKYDAPFIDTPIYNNELNLIFPIICYKCLKHIDFNKLTLSILFLNQANYLIKLLLSNNPNEFNEIIEIVISSIGLIGVEKVKRVLLEICKLSKYCSRFIRTELINRQMLPDLVLLITSQFVKDEIDLLSNIISNRIENQWLKEYISQKDQFSTFNEIRDSLFSTLELISKEISSNSNNNSNNLEHSFIVKSIIRLYCGFSGLLGIKMNQQEISISLSFIEKSIFKNYSKIFLCFLLVCEGLVKTIHPKKELVGYLNHLCKVGNCDELLLLISIYFHTHQLQNIALLVKNILGFRPSIHTESLNQIGEILTKEIYTESLVAKRAQQLPIIEKLNTNHQNISIVCVYHLLSERIFEKYETDVGNWCWSQLTKSSTPIHYLLPSLLDQLCKNIIEPSINNNNTSSTTSIINTSTTAAAASTTASNANTTAATTTTTTAATITTATTTGTTTGISPSSSTTTTSSTGGATSTSISSPNSTSLGNSYLFSTFSSTSSSSSSGLPFYMKRISESIIMNSIQQSQSNLSVQILIIYFVLRYNDSVIKFKSEQKGKPIQFLIETTQLREYNIEFLSKLPIQNCINVILSNQSDYFYIIPPFLYLILSQFPQFFNINLLLLEEERLLNPIEKFIYLPNFYSINGGANNNSGGITNEFLKDTLKRTLSQPTSVQLILRYLNTLSVKELLPFTTTLLDNLLPIIIKNRSLPSVSALISPFVEIWERVFPISQSSIALKTINILTCINDDKSTNNNKDLEDYNNNNNNNNDDVKMKDKEKEDKEEEEEEEILLPISNYTYTDIISDPLVIFRSHPTVFTCPPLFKILLQILFFYMVSSKKNLQNQLHTSSGSGSGTTSNVTLNKQQQEDVSTLILTQESTIIQILLEICLIDGIDTKGLNKILRNKNKKFKESYDPVDIEEIRCQICSFIHQMFIDKPLIIKLVHFQGYLSQLLPITVTLIPSMHICFEFIPELLAQPSLEKQIFAIQLLSYLSEKFPIPKSLKICRQSQTRISFNLNSNTLSYDDRIKFLHSILPSITRITKTFPLLAEDFVSILMEQLPNKHNYQQNLKSFISSIDFNLNSNLNNYTNSIYLQNNKNNNNSSNNNNSNNQNDLLNIDIDNNINSNNNNNLRNINFKKVSNDDKSFFSKVSKNESWLSIKENNDPFNIPIEQEIHQAIQIIIKNLSK", "function": "Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.", "AFDB_id": "AF-Q55CB6-F1-model_v4" }, { "swissprot_id": "Q61WR2", "sequence": "MSTTGHRAGVFKKPAKPHKSWKGKRTKGEITTENRGREGVKQLTRSAHSTHRAVSKDARRNQLKMARDRKMADAMERRRTSNAPCLVTILSLGVGARPSEFLKKLATCDETIVQTHSPSTIDFAIPRFKSRISFLTPDKENVDSVLDAIRASDVLCFLWPLSAELSEWDEQLLTICKAAGLPTIVSVVPGLGGIQNHKKKEDVRKGIEFTISKWSMSNAGVMPADSVTDNLQLLRTLNETKKKPLTLQARHSYMLVENLEATESPEDSSKITLKAQGYLRGPEWNANNLIHLPGFGDFQISKIETAADPHPLKTSPPKGAEVIAKADEKRQSLETEITLDAMDGEQTWPTQEELEEADKEMRRVPKGTSSYQAAWILDDSEDDEDEEDEDEDMDDEEEDKDLEEDDEEEDTPMDLKSEAGETTASEMMFHDEIDEDINLAEVEKYRKERENAQWPDEVDTPIDQPARIRFQKYRGLKSFRTSTWDAKENLPVDYARIFQFANYKNTKKNVMSKIGGNDVDAGDAVIDKKFNGVFASVYIENVPVSVMEAYKETKNLVLFQLLPHEQKMSILNMVLKKHPSCTVPIGSEDQKFIFYVGFRQFEAHAVLSSNTPGDKFKLERFMPTEKTFVATVYAPITFNPATVLCFRQDDKGRQELVATGSVLDTNPDRIVLKRTVLSGHPYKINRRAVVVRYMFFNREDIDWFKPVELYTPSGRRGHIKEAVGTHGHMKCRFDQQLNAQDSVMLNLYKRVFPVWDYSLFNRNLNPSRFVERSRVESISLVQEDAMEE", "function": "Required during maturation of the 40S ribosomal subunit in the nucleolus.", "AFDB_id": "AF-Q61WR2-F1-model_v4" }, { "swissprot_id": "C4LF05", "sequence": "MSERGYELKGSVFTMTVLHLEDAIPEQIQQLLEQKASQAPKFFDSAPLVINVEMLTEIPDFSKIMSAILTANFIPVGVTGVKSNEMREAAKQARLAILTAGKETNTDAVVLHTPKESIYKTPSELREEQQTSPGTTADPDNLVPTKVVQGNVRSGQQIYSPGPVVILGSVSNGAEIISNDSIHVYGTLRGRALAGARGNHDARIFCGHLEAELISIAGHYLLSDSLPEPHVGQEVQISLENEKIIFDKLTS", "function": "Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.", "AFDB_id": "AF-C4LF05-F1-model_v4" }, { "swissprot_id": "P78552", "sequence": "MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ", "function": "Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.", "AFDB_id": "AF-P78552-F1-model_v4" }, { "swissprot_id": "P30347", "sequence": "MTLKLYSFGPGANSLKPLATLYEKGLEFEQVFVDPSKFEQHSDWFKKINPRGQVPALWHDGKVVTESTVICEYLEDVFPESGNSLRPADPFKRAEMRVWTKWVDEYFCWCVSTIGWAFGIKAIAQKMSDEEFEEHINKNVPIPEQQLKWRRARNGFPQEMLDEEFRKVGVSVARLEETLSKQDYLVDTGYSLADICNFAIANGLQRPGGFFGDYVNQEKTPGLCAWLDRINARPAIKEMFEKSKREDLLKRQNEKVA", "function": "Lignin degradation enzyme.", "AFDB_id": "AF-P30347-F1-model_v4" }, { "swissprot_id": "Q5FI54", "sequence": "MSISLNTCILILKEHHLLKSSAVQDTVATKMDYVSYDSRDIQTNTLFFCKGAGFRPTYLSMAKSNGANCYVAEQPYPEGKGMHALIVRDVSKAMALLSAAFFRFPQDDLYVVAFTGTKGKTTSAYFLKGMLDQANGGRTALISSVNDVVGPKPEDSFKSSLTTPESLDLFRDMRTAVDNGMTHLVMEVSSQAYKKNRVFGLTYDLGFFLNISPDHIGPNEHPNFADYLHCKLQLMVNSRKCIINAETANFNEVYAAATTTTNPDSIYLFAREDFENPDLDVPIDFRFASQELDMKETRFKLFCATDKAKKLPINGDYTLKMLGDFNESNGTAAIIGAGLAGLNHDQCAKGIRNVTIPGRMQTERTKEHGMVVVDYAHNKASMMALMRFMQNEFNDPKIIVVVGAPGDKGVSRRPGFSESLSAYADKAFLTTDDPGFEDPKSIAEEIDAGIDHSKCDVTIELDRKKAIHDAIASAGPDDVVLICGKGADAFQKIRGVDTPYPSDIVVAQQVINELEGQDEHFRK", "function": "Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.", "AFDB_id": "AF-Q5FI54-F1-model_v4" }, { "swissprot_id": "Q16533", "sequence": "MGTPPGLQTDCEALLSRFQETDSVRFEDFTELWRNMKFGTIFCGRMRNLEKNMFTKEALALAWRYFLPPYTFQIRVGALYLLYGLYNTQLCQPKQKIRVALKDWDEVLKFQQDLVNAQHFDAAYIFRKLRLDRAFHFTAMPKLLSYRMKKKIHRAEVTEEFKDPSDRVMKLITSDVLEEMLNVHDHYQNMKHVISVDKSKPDKALSLIKDDFFDNIKNIVLEHQQWHKDRKNPSLKSKTNDGEEKMEGNSQETERCERAESLAKIKSKAFSVVIQASKSRRHRQVKLDSSDSDSASGQGQVKATRKKEKKERLKPAGRKMSLRNKGNVQNIHKEDKPLSLSMPVITEEEENESLSGTEFTASKKRRKH", "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.", "AFDB_id": "AF-Q16533-F1-model_v4" }, { "swissprot_id": "G5E869", "sequence": "MTDPVLASQLANGTGEMDGLCSELLLIPPPLSNHGILGPVQNTCASGELAPLPADPGCLLVEATATEEGPGNMEIIVEAVTGTLSPGAPEETSGVLVKVVEVYFCERCEQSFAEPTLLSVHQCTETHIQAVQDLSSPPCSVELPPSNLALRGPLQDPSLPDSPLPCPVCRQEFVQPQALKSHFKIHRVTPNMFSCPESGCVFSAEDRKGLQNHLRQTHKAVPVPCSFRGCSLLFGSQQGMELHRQAHYPFHCSHCSFMGSNVKLFRQHQRSHGASARGELSAAVQGLPSQELLPAAKLPPGHREPSEEASTPLPGQESAEEEDAEEEESVTQKDSQKVMDKSQGAQQLEGHVGSGTESLFKTHMCPECKRCFKKRTHLVEHLHLHFPDPSLQCPNCQKFFTSKSKLKTHLLRELGEKAHRCPLCHYSAVERNALNRHMASMHEDISNFYSDTYACPVCREEFRLSQALKEHLKSHTAAAAAEPLPLHCFQEGCTYVAPDRKAFLKHLKEIHGVRAVECRHHSCPMLFATAEAMEAHHKSHYAFHCPHCDFACSNKHLFRKHKKQGHPGSEELRCTFCPFATFNPVAYQDHVGKMHAYEKIHQCSECNFATAHKRVLIRHMLLHTGEKPHKCELCDFTCRDVSYLSKHMLTHSNTKDYMCTECGYVTKWKHYLSVHMRKHAGDLRYQCNQCSYRCHRADQLSSHKLRHQGKSLMCEVCAFACKRKYELQKHMASQHHPGTPAPLYPCRYCSYQSRHKQALLSHENCKHTHLREFHCALCDYRTFSNTTLFFHKRKVHGYMPGDQVWQFCNASQELEGARQCLAPPSDSGPSSQLSAQPEREDREHEIVANSNMDQALPETNEEASPKRQDGIEAPQEDDQVDSPSLGEVEEGGCTLHLEALRVELEPETEPLPLEELTETATVEFRPLDPSGPLGTERPGGLEEPALSSFDSIETPALVAEEEPVVEKLASEPPRNPLISEEAPNTFKAALTAETVPLPPFPESESLLKAMRRQDKEQAEALVLEGRVQMVVIQGEGRAFRCPHCPFITRREKALTLHSKSGCQGRREPLLCPECGASFKQQRGLSTHMMKKCPVLLKKNKALPKPVSPTLHPQLPDNQASQDAESRKPPPLPSKVELLLPKDAPSDLPGGPGVEEPLPTPSDFPTSPPENSLPTGTSEKFHFEQGKFHCSSCTFLCSRLSSITSHVTEGCRGGRGQKRKRGRPQTHAVVLPLNNGDSTLLNTGSTESSPSDGDTAVVQKQKGALFSCPTCPFSCQQERTLRTHQTQGCPLKSGDLHCGLCPFTAPAAAALRLHQKRRHPTASPASGPRPLLQCGDCGFTCKQSRCLQQHRRLKHEGVKPHQCPFCDFSTTRRYRLEAHQSRHTGVGRIPCSSCPQTFGTNSKLRLHQLRVHDKTPTHFCPLCDYSGYLRHDITRHVNSCHQGTPSFSCTQCEAQFSSETALKQHALRRHPEPTPPSSGCPVEVTEGPLHCSHCGLLCPSPASLRGHTRKQHPRLECGACQESFPNRPALDEHRRQHHFSHRCQLCSFAARERVGLVKHYLEQHEESSTAPSDGDAGQPSLCCPFCDFACRHQLVLDHHVKGHGGTRLYKCTDCAYSTKNRQKITWHSRIHTGEKPYHCHLCAYACADPSRLKYHMRIHKEERKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQCPECEYCTNRADALRVHRETRHREARAFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHRAFRWAAGLRHHALTHTDRHPFFCRLCSYKAKQKFQVVKHVRRHHPDQADPNQGVGKDPTTPTVHLHDVKLEDPSPPAPPAPSTGPEG", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-G5E869-F1-model_v4" }, { "swissprot_id": "A9RGD8", "sequence": "MEHPLECADSCSLAMSWFCNKKCRGWGLMKRTVVASGLRSVVLLLLFIYFVQDVTAEMGHQRISGSAGDVLEDNPVGRLKVFIYDIPSKYNTDWLKKDPRCLTHMFAVEEYLHDFLTESPVRTLNPEEADWFYTPVYTTCDLTPNGLPLPFKSPRVMRSAISYISSHWPYWNRTDGADHFFVVPHDFAACFHYQEEKAIERGILPLLKRATLIQTFGQNHHVCLKEDSIVIPPYAPPERMQTRLNPPSTPRSIFAYFRGLFYDPGNDPEGGYYARGARAAIWENFKDNPLFDISTEHPATYYEDMQRAIFCLCPLGWAPWSPRLVEGVIFGCIPVIIADDIVLPFADAIPWEKIGVFVEEKDVPILDKILCTINHEEVLEKQRLLANPAMKQAMLFPRPAKPGDAFHQILNGLARKLPHDPSIYLQPGQSFLNWTEGPPGDLYPWGNDL", "function": "Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.", "AFDB_id": "AF-A9RGD8-F1-model_v4" }, { "swissprot_id": "Q1DLJ4", "sequence": "MAKIKKKGTSGAAKNYITRTQAVRKLQISLPDFRRLCIFKGIYPREPRNKKKASKTSTPSTTFYYTRDIQYLLHEPLLKRFRDQKALSKKIARSLGRGDVGDAARLEKNNAPKITLDHIVKERYPTFIDALRDLDDALSLLFLFANLPSTANVPPKTIALCQRLCHEFQHYLIATNSLRKSFLSIKGIYYQATIQGQDILWLVPYRFVQQVTGDVDYRIMATFVEFYTTLLGFVNFRLYTSIGLVYPPKFDSRSDERGAELAAFTLEGRKVGEMQKAISSEPQTNGQLAKSDSAANDIQAKVDNILKETTRNNEPDDEAVDVEDNVDAIDKFETTAPEADTLPQPQMSGNEVASLFASFTFFISREAPRGPLEFLLRAFGCKRVGWDAVLGEGAFTHDETDPRITHQIVDRPPLPESALPPLPQNPGEGAEKAPRVRPGTRMPGRMYIQPQWVWDCVNEGKLLRHDLYAPGATLPPHLSPWVKASKGGYDPRLSLAEQESDGEAERQAEEENEEEESEVEGLSMDKEMVETENSEAGESDEESVDGGMDVDIPGSDDEEEESEEDNALRELGGSDEAADVQSESEDDEEAARNQHQMELEAEAAGLPFTGADGTGTSSKKSKKQKPLAKKHAAQKKKEQEELERQKMMMSRKKRKLLDKMLYSNKKKDEEAEKLRRKRRKIEQGTKGR", "function": "Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.", "AFDB_id": "AF-Q1DLJ4-F1-model_v4" }, { "swissprot_id": "Q9ATE5", "sequence": "MIIMGRGKIEVKRIENKTSRQVTFSKRRAGLLKKTHELSVLCDAQIGLIIFSSKGKLFEYCSQPHSMSQIISRYLQTTGASLPVEDNRVQLYDEVAKMRRDTLNLQLSLQRYKGDDLSLAQYEELNELEKQLEHALNKIRARKLELMQQQMENLKKTEKMLEKENHDMYQWLMNNQMYKQESAAMDHEDHHHHHEHQQAITELNLLGEQPLLSHFTFFGDQEQPSTSTVNHFASISLTSPPANSISPYRLQPSHPNLQDSHVHGPSYD", "function": "Probable transcription factor.", "AFDB_id": "AF-Q9ATE5-F1-model_v4" }, { "swissprot_id": "Q3KPW4", "sequence": "MMDGTHAIKRSRSRSPKVSQSKSSKKKKRSSSRCRSGSDSPARKHSTLAKYRAEVPDRRKKERRKKRRKRTVSTTSSSSSESSSSSSSSSSDDSGDSTCKSKRSSHRKKKNKKQIKRKKAKKNKKLKKKTSFKLECQDTKSTEKEVLPGPSVNPCKKESPEVSGPALTDEQKSRIQAMKPMTKEEWDAQQSVIRKVVDPETGRIRLIKGDGEVLEEIVSKDRHKEINKHATQKDGLEFQMHSGMF", "function": "May be involved in modulating alternative pre-mRNA splicing.", "AFDB_id": "AF-Q3KPW4-F1-model_v4" }, { "swissprot_id": "A2VDJ0", "sequence": "MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGELLLPTQGDSEEGLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVLSYHVSGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASFTCKATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV", "function": "Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.", "AFDB_id": "AF-A2VDJ0-F1-model_v4" }, { "swissprot_id": "A0A1C3NSL9", "sequence": "MSTTTPEKPEEIIDATGTSDTAEKIEVVISKEEPAEQKNEVEEPDYAQVPAESEDDAAQELAPTDSAIQVVHVLEAPQKAELVTIPLAHSEAEDHKLADADRDQEEELVFNEERRKTVTMDDNASLRSASITFDANRDEQDLLNESFASNPTDETVLMQKTKDEMDATSERPRSPLDLPPPPASVVLHPSAPPPPPPPLSSTEVVGNTTTTTTTHYAPKTWNDPSITTAPKIPVSLLSGAQPLPSVLTQRTTTSSYSAPNYSASSMSGVPSDVAPPPPLPIPNQSSSSAASYQHHHASSISKSISSSREDLLSEHATSRSTVREIPVHRAPSTAPSHSSVFEYHMMPTTTSTYHHVETPSDEYYRREVMTRTIITRSTEALSQTPLGRPASPLDRYLPYPTTTTTTSGDGRTREEKTVDYKVTYHRDIEEQERRIREDQARRQQEEQDRRDREDNARRILAQREHQEMERLREQQNLSERALAERERADKERLQQERLLRQQREKKRREEWDRLESIRLAEEEAELARRRALEKERIDREKAEEERKTMERLERERARLERERLEEERRQKEKAETERIERERREHERIEIERIERIKRERIERERREREEKKAEEDRLLRERLELERIERERRELEARERQELELQRREAEDRERQRLEDEAREMRRREEERREAELVADVHRQAEERERLRKRQEREEAERLERIRLEQQKIDMERIDAERRERERKEEERREFELIEAARRKKEARDRDRLDEMERERVREEEERREKERREQERRIAAEKERKRRQEEEEEIARLNELQRAAAARQAQRNAELDRQRQRDELDRKAQELSEREMREKERRDRERANEEAQLADLLERERHNQLIRENERREAVERANNRRLEDRRSRDKLDHIVRERSEKEQFELEKRRLLAEKEAMNRKKNHLLSSETLAKLTQPMYYTTREPEVTTKVERQVIERIDRNVWVEDVPYAPSQSAMGYLDNDENNRDRLYNPNDLNRNGSSRSRYQRAKNEKARRDFYHSSQDSADPVTERFRKSTDDLTTRSRPEYRGPLLQKFHDSEFRTTALNETDGLPYRRMGPSPYEQPFAKLLEETERRYAHYNSRASNPSIYQSSRYYYPERHGQPQHTDNTRAESVVAYERESRRESPADQAHIRSRSADYLMDRRIREETEVPENQLQKTRVEPHDQSPRESRISEYEMRFRKSTEKLTVPDWYRENRPQGQTAQTSTYRYGNGVEPMSTTTTTTTVINGTSSHQQAPPPVPPQPIGNIGLPRGMFDRYKDDIEELRRSRSSLHQTGQQETSNRQGSTLSVGGIVDQGHALPGYTVSEVPNAWNLHTSRTSRVVEVADTFVGTSSHEYGNFTNRYGGRVTIEEVLDSIFQKVTPTNQRLNFDRSYPQADELFQGNVDGPGIYTNNYSVMRQVLKSPERAEHILQNEELFVRCTECHRTRELSAARLFFVSCKHCYTYYCSRECRHNNWPNHSGRCSFARINTLCKDVIMKVREDEQAQAFMSKVARDGFSVSGRGSVNIRLSSPQLAQAYVSNGWRALSAYPNDQLLYYYTVKALIAERKEPSLIALCNRYEPREKFILSVSIIADIEHCPETPPPETRELSAVQFSSPRSRYEAIQNQNAPYFSEFAHNV", "function": "Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos.", "AFDB_id": "AF-A0A1C3NSL9-F1-model_v4" }, { "swissprot_id": "P11545", "sequence": "MTTVRTGGAQTAEVPAGGRRDVPSGVKITALATGFVMATLDVTVVNVAGATIQESLDTTLTQLTWIVDGYVLTFASLLMLAGGLANRIGAKTVYLWGMGVFFLASLACALAPTAETLIAARLVQGAGAALFMPSSLSLLVFSFPEKRQRTRMLGLWSAIVATSSGLGPTVGGLMVSAFGWESIFLLNLPIGAIGMAMTYRYIAATESRATRLAVPGHLLWIVALAAVSFALIEGPQLGWTAGPVLTAYAVAVTAAALLALREHRVTNPVMPWQLFRGPGFTGANLVGFLFNFALFGSTFMLGLYFQHARGATPFQAGLELLPMTIFFPVANIVYARISARFSNGTLLTAFLLLAGAASLSMVTITASTPYWVVAVAVGVANIGAGIISPGMTAALVDAAGPENANVAGSVLNANRQIGSLVGIAAMGVVLHSTSDWDHGAAISFLAVGLAYLLGGLSAWRLIARPERRSAVTAAT", "function": "Resistance to the epoxide antibiotic methylenomycin A; probably by mediating its efflux.", "AFDB_id": "AF-P11545-F1-model_v4" }, { "swissprot_id": "Q8L831", "sequence": "MAEEHFDVLTKSGEKTGVSKPRGEVHRDGDYHRAVHVWIFVETTQQLLLQLRSDDKDSWPGQWDISSAGHISAGDTSLLSAQRELEEELGVKLPKDAFEKIFVFLQECVTNDGKFINNEFNDVYLVTILHPIPLEAFTLQKEEVSAVKYVPYEEYRNFLSKEDPAYVPYDVNGEYGKLFDIIRQRCQVNTEARSLSLQKQLQRYSPVTLEAKLTELSEADQKALGLIVKAAKIMDDIFYEQVWNSNPALRDWLKDHANASKLDKLKWDYFTINKSPWSSLDENEAFLSTADSAVKLLPGATKAIAGWKGLEYRAAFPVTKPPGANFYPPDMDKMEFTLWLNGLTEEQKHAATGFFSVIKRRSEANLDASDHLASSTKKLPDSNSDLYSIPYSEIYRPFLKKASEFLQKAGDLVSSPSLKKLLHSKAEAFLSNEYYESDIAWMDLDSKLDITIGPYETYEDEIFGYKATFETFIGIRDDKATADLKLFGDNLKLLEDNLPLESVYKSTDVSAAPIRVIQLIYNSGDVKGPQTVAYNLPNDEKIVKDRGTSMVMLKNVQEAKFEHILKPIAEITISKEQRGLVDFDSFFTHTICHECCHGIGPHTITLPGGQTSTVRKELQEVHSAMEEAKADIVGLWALKFLITKGLLSKSMVESMYVSFLAGCFRSIRFGLTEAHGKGQALQFNYLYEKGAFVFHEDSTFSVDFAKIEGAVESLSHEILTIQGKGDKNAATLLLNKYCTITGPLKTALENLERVKVPVDISPTFPLAEALMN", "function": "Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.", "AFDB_id": "AF-Q8L831-F1-model_v4" }, { "swissprot_id": "P96119", "sequence": "MTMEVVLIAVVVSVACALCGVFLVLRRISLMSDAISHSVILGIVLGYFLSRTLSSFVPFVGAVIAGICSVICAELLQKTGMVKSDAAVGLVFPAMFGLGVILVSLYAGNVHLDTDAVLLGEIGLAPLDRVSFFAWSLPRSLVQMGSVLCGLLLLLALFFKELKISTFDPVLATSLGFSPTLINYGLMLAVSITCVGAFDSVGAVLVIALMITPPAAALLLTDNLLLMLVLASLLASCASISGLFLAVKIDGSIAGAMATMAGVLFALVYLFSPKHGVVRRCLVMRALKLDLDVVTLAVHLATHRYTVERSVECAEVHLTEHVSWSARRAARVVRTALRRGMVERHGALLLLTAQGVSLAQARLDVSV", "function": "Part of an ATP-driven transport system TroABCD for zinc.", "AFDB_id": "AF-P96119-F1-model_v4" }, { "swissprot_id": "O34996", "sequence": "MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMILMKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQISRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVEFYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLESIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFKDLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEEPILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELKGAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEHLGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMGEELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLEKLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTDPNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTNDMDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFIDRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNTPIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVMEHALALDVPLKVDFASGPSWYDAK", "function": "In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.", "AFDB_id": "AF-O34996-F1-model_v4" }, { "swissprot_id": "Q96L08", "sequence": "MRWAAATLRGKARPRGRAGVTTPAPGNRTGTCAKLRLPPQATFQVLRGNGASVGTVLMFRCPSNHQMVGSGLLTCTWKGSIAEWSSGSPVCKLVPPHETFGFKVAVIASIVSCAIILLMSMAFLTCCLLKCVKKSKRRRSNRSAQLWSQLKDEDLETVQAAYLGLKHFNKPVSGPSQAHDNHSFTTDHGESTSKLASVTRSVDKDPGIPRALSLSGSSSSPQAQVMVHMANPRQPLPASGLATGMPQQPAAYALG", "function": "May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.", "AFDB_id": "AF-Q96L08-F1-model_v4" }, { "swissprot_id": "Q9Y2F5", "sequence": "MMPGETHSAAPGTAADLSRCQGCASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYARVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSYGSIDKRKVKLLLKELWLCVNTTHRLPGEGSRCVPEKPAKAITSSRVPGEDGTLPPTQGSPLRTSNVQTCLTKLSMEIKEDFLCQNVEKQSSSGTNCSSDHVFNENGNLEVLVQSHRDGGSTEFVDHDHFFDEDLQAAIDFFKLPPPLLSPVPSPPPMSSPHPGSLPSSFAPETYFGEYTDSSDNDSVQLRNSAECVSEDDTTESQNYFGSLRKNKGSGTWEEKPKSHEAIQALNTWEVNKVTTSGLETFTATLRESSATHSLVGEKHWTTASRSMSDRKRDILHETKTQMEVREMDKSVQTEKTIHKLTRGLCIERLSASPAQEKEAAPGKSELCSSPLGKRPLNELMESEGKTVLSKMMGSPKSEFTKWTRINEITSEPDRITVSGHFHRLSRELEKEKEDTQGFTLGESPESEDDDSGDGMDVAGLDIETSFSSSSTLVALSVGSNPQSSSGLDCGNDTDITTKVFSTEPHHSEHKLQTKTLNTLHLQSEPPECSIGGNNLENSLCALSPELGASNFNDQKSSGIEYTKVVKGLTKIHSLPRSVFMKATKDGQCESQDPRIELTLNKPDFTSLIGSQAALIKSGLGFVKSTSWHHSDLLRKGGEESLRAKSEHEQKTSHQLQKAMPFLQNRGPTPKPDLLRENNNPVEFKTTASVLPNQVSVITKQTRPEKVQSAKLEHLRPHRVEPTLVTENSGNKTGMSTVAKCDGERDDTTQNITEVAAVKSISPEVSASRRKLDFNSPGGSSPVENSDCSTNSRLSFSPENILIQNQDIVREAAVQGDGQKQRQPQATDLDSSGTHGSEMLPATEVTVSGGFSVEETSCGDTGRSGGEALAVANDSTSTPQNANGLWKLKSTTPGGALPECFGTTDTTFSSAFCRKHGETQDTSQSSLPGTLHCYTGIREGGDDTEVESEAFSCSEGSEQQDAPDDSQKNLGDTDAAVAEVRPSLEVGYLTSALQDFNISTFSELDRLSTSEVVMFLESCQLGDYSSGDSVSECSSKGTLSKEMNKELKASEIGEKYRKQPCEEETLGTCEEWIESEEDDYSLKNTSQLTQCSLETLSEVLTKIRQELQTNSEDCNGKDTGSLLLLNVNNNMTTENLKEKSPFRETTGSSSHASEPTPQAAALDTEGSSPISGMPQNENPQSRPEARSDAGRQTDGGEEDLPEPVEPSALCSDSVMEPSIEQSSNCEAETTFQCQIATVTSEVINVLINKDQNLVIEKGDNWTIISGVAVLPHVDQVTLCDIPGDIPISQDQGELEAGCIPVTSAEKSPEASHTGPAFQEAPCGNNLSCPQEDVSSSGQSTNFDKSRLRNRPVKPSIWISSQIYDQNFETQIVASDHTYYNSKLEPSGKNKNRSKISNKDQSNKPVKTSASSRVETHQSEVAQSFSGEKANTKTQRSQTQTILANADTSTPTDCSPDTLSKIRQEVGPPLPPLLAPLIATPPRTSQPLSPLISSSSPSSPASPVGQVSPFRETPVPPAMSPWPEDPRRASPPDPSPSPSAASASERVVPSPLQFCAATPKHALPVPGRLPPCASGHAAVGGPQENSVKILDTMYPELSARARTLNILKGNIQLTRGPPADCKNLPGPASAMIGFKTITSAATAFVKTGSSSGGDCNQDKSRDLGTQQDSSGKRTLSTSTLRSAKRLRLDTGSPEPETRGVTAEGIHKNLPGNLPPAEVATTNEERSCSSPAVSAVSQLPLSPKETVESHDKAIANALKKIAEFSFDLLPVIRSHVYVGNISKKPVMRDQEKEVVYEFSTTKKHLAECLLHSILSELKIQKISMDHNYIHALCRVYVGICRQLGDLERARLFCYSLLKEDFPESEKLTLFIANMWHDIFLSQSVINKAMQLVARQRAKGEVLNCLRAFLNWEKNAPVDVGFMVSKLLLTIQLCPKTEFQPSEKFGEDLSDNTWEYIFAIDLLCCHQKWIWTHDNIISKELWPVMDKWIKYRKGHANIAYTPDIIIASILRLIGRLGQLGLKEGFPSAVKNISSVIGMFIQHAHDEDIPWGIQLAAVYALCDLSPSNPAEISKILEAWRREASKSVPSAIVSCLEEVSALSTEELG", "function": "Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies.", "AFDB_id": "AF-Q9Y2F5-F1-model_v4" }, { "swissprot_id": "Q8ILP3", "sequence": "MKIPFFILHILLLQFLLCLIRCYVHNDVIKFGEENSLKCSQGNLYVLHCEVQCLNGNNEIIHKRCNDDIEKKCNGNNKCIYFFEYELRKKTQSFRNKNSIEISECVESEQNEVKTSTTCLLSNSFILDEAFIQYFFFIKNKNEEPVICKDGNINIKSALLHSPFCEIKLKDISEYIRKKCDNNKECLIDPLDVQKNLLNEEDPCYINNSYVSVNVVCNKEEEIGDESTDSSSMEIQDSTSNEQDENVKGMSSSQEMNSNNDENKNQDNESDDDVNNNNNNNNDDQDEQGNDGDVTSSMNKNEDNKDLEHGSSNDVNNNTDTLVNNKENKEFVLKEKSSLTSKINKELAHRTALFNKLADNISLLLNKKYDSFEIKDVLEDRYNEMKRDANPDVYYIYLMDTLDIEKIEDINLEEVKMSLLASLKETMNKIDTIEKKIEEFKNKYISLYNKVKTTMPELFDLNEDLVLLYNDFPFDNGMISSDIFFKYNPSENIMDHQEMVKKGSITEDELRIVNDLEPLDNYRRRKRITELRKILVEKLRILYLEKNNLFNTQASCIKSYCYKNPLNLKTLEVLLKKNYYRLKENKDYDVVSSIIQHLDNVDANKKKKWLTHERILKKLQVLIAEGYKRINEKEKDIDRRMAVYNALYEKAQSYNLQKLFNDSNDFLKKYAIMGNSFDDGDEVFGSQSSNFNIFDSNNTDQNNEQEQPKQDDQLLNNNNDDVLSESNNENKEKTSDDATHKETQEKSDQEPSQNIQEDNSDEKHAENEENVEQIETDSNVSEEANDENKDNMQTTTDEGTEELQQNDEDAESLTKENSKSEEQENEDSTDAEAIDKEEVETEEKGKDEQKKDEQKEQDEEEDGEKENKHKSSETTNETVTDIEENKNEVKGEEHLQGSEQSIEASESSQKDETKETEDKEEYVNANDDESSEEDTTPNETNKTDNGSSFFFAMSNALLVILLLLFIEFL", "function": "Membrane receptor which tethers secreted RH5 to the merozoite membrane during merozoite invasion of host erythocytes.", "AFDB_id": "AF-Q8ILP3-F1-model_v4" }, { "swissprot_id": "Q02204", "sequence": "MSSLLKLHCIRPLPQRSVWLSGYKQKARCIHSSAANGDFMSWFKRKKQEEHQEPVKDTKQLIKDIEEGTNEASSQSSSNNKNRLELIPENFIGEGSRRCKRQKELKLAVSSAPFNQWLSRDKITSDNQLDDMILQATEKTLGKVDQDVQFSDLVAKFQFTKFLQSKSGYLIPDYELTTLSTPLQFKRYIKEKILPSANDPKLAYKEAEPNAIHPFSDNYASPNIYVVNDVTSKEQKSKYDTIMKEIQKLEDDATRKALETARSA", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.", "AFDB_id": "AF-Q02204-F1-model_v4" }, { "swissprot_id": "P10802", "sequence": "MSEIIRVPDIGGDGEVIELLVKTGDLIEVEQGLVVLESAKASMEVPSPKAGVVKSVSVKLGDKLKEGDAIIELEPAAGAAAAPAEAAAVPAAPTQAVDEAEAPSPGASATPAPAAASQEVRVPDIGSAGKARVIEVLVKAGDQVQAEQSLIVLESDKASMEIPSPASGVVESVAIQLNAEVGTGDLILTLRTTGAQAQPTAPAAAAAASPAPAPLAPAAAGPQEVKVPDIGSAGKARVIEVLVKAGDQVQAEQSLIVLESDKASMEIPSPAAGVVESVAVQLNAEVGTGDQILTLRVAGAAPSGPRARGSPGQAAAAPGAAPAPAPVGAPSRNGAKVHAGPAVRQLAREFGVELAAINSTGPRGRILKEDVQAYVKAMMQKAKEAPAAGAASGAGIPPIPPVDFAKYGEIEEVPMTRLMQIGATNLHRSWLNVPHVTQFESADITELEAFRVAQKAVAEKAGVKLTVLPLLLKACAYLLKELPDFNSSLAPSGQALIRKKYVHIGFAVDTPDGLLVPVIRNVDQKSLLQLAAEAAELAEKARSKKLGADAMQGACFTISSLGHIGGTAFTPIVNAPEVAILGVSKASMQPVWDGKAFQPRLMLPLSLSYDHRVINGAAAARFTKRLGDLLADIRAILL", "function": "The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).", "AFDB_id": "AF-P10802-F1-model_v4" }, { "swissprot_id": "Q12192", "sequence": "MSTNTEIIKNSDLQSLINDKRRLINEIKDFNKSIKPLEFESYQDYFLIKTFKKGISASGHVDIDSLRNKEYGIYYKKIKRNSTQEVGEPIPRNTSSSSSSTRSNSSADISDTEYSGENTPTTTGAASRRRRTRSRAIQRENSLPASLPSISEANANNDDVTISEINGSELPFPIPISEVENIDIASDITERDGIRRRSSRISERDKRRSQSRLGSEEDEEGDGHDGDEGETKIQDLYESLVPKILESRRRSDWILPPKARYTPEKQMRTKPSFKSIKINELVGNKRIRSILSRFEGGVAGIRKRDWDSTQ", "function": "Tethering factor required for histone deacetylase HST1-mediated repression. Probably involved in targeting HST1 to a subset of SUM1-regulated genes.", "AFDB_id": "AF-Q12192-F1-model_v4" }, { "swissprot_id": "Q3JCK6", "sequence": "MLILTRRVGEALMIGDQVTVTVLGVKGNQVRIGVTAPKEVTVHREEIYARIQREKEQANGRGQVSESEFTEEAFRAAPAISGSGE", "function": "A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).", "AFDB_id": "AF-Q3JCK6-F1-model_v4" }, { "swissprot_id": "S0EH60", "sequence": "MLLQASQATQSVWKTLNKWLPPLSRDKDWWWKTLGPQINTLLTEADYDLNERYEALLLLYRWVVPEMGPRPRSSVAPSKSFMTDDHSPIEYSWKWISGNKKPEIRYAVELVSPLAGSKQDPFNQIPTRNLVYNLAKIIPELDLTWFEHFWHELLGPGSPTTSTSGVLTKGSTVFAALEMLHGHLSVKVYFIPVETPDFSAWHQIKHAIEASGCPNLEALNHVDAYLSSHDDGRQLRPFMLAIDLVEPAASRLKIYARSNQTSFRFVRDVMTIGGLRTDLDRSIEKFSDLWKRALGLDPDTPPEDELPKVDHLTSGAVFNFDVAPKSQIPEVKAYIPVRHYANNDLQAALGLIGYLEDHGHGGYSQSYLRGLDMLAPSGQLDQATGVQTYFAVACQGEDLSLTSYLNPQFYAAFQEPERT", "function": "Dimethylallyltryptophan synthase; part of the DMATS1 gene cluster that mediates the biosynthesis of a reversely N-prenylated monomeric L-tryptophan (r-N-DMAT). The main product of the cluster is the r-N-DMAT produced by the dimethylallyltryptophan synthase DMATS1 and it remains unclear whether this metabolite undergoes further modifications when silent gene clusters are activated. The acetylated form of r-N-DMAT, ac-r-N-DMAT, is also produced. The roles of the cytochrome P450 monooxygenase FFUJ_09176 and the methyltransferase FFUJ_09178 have still to be elucidated (Probable).", "AFDB_id": "AF-S0EH60-F1-model_v4" }, { "swissprot_id": "Q6GV23", "sequence": "MSSKGGSSRLGSKDLKKMTSRTERELRDSGRVRGEVERVEKRLRATAKVKEQPPTGDYKRRALASPGETAAPTFLVDSRGIPRKTSSTAPRKATLRPASSSPRLASSSRPTESTLPSSSSRALQGASSSSSSRPRRLHESASGRGGSGGSAGELRQEKKRLPELEAAEAAPASCVVELRDVTARKGRTSPATPPETAGSSVCGQGSHARTAEKLEEGTASHRDGSRRGSVDAETWATPGDGSSSHEFESSPQREERMQPQETGRRELSSEPRSGDLTKNGGDGGPRRHSCAWRKWREHMIQSFDITTHPFPPRGDGSPRRGKFLMIFLTSSVLFFVFLQELVLNVTTFNGRCMSPVLYPSHDAPESERTPRVISFGYGACEHNLGVSLFRREETKKDPRGRWTPGPLTERCASGRCASDDGWPSDLVQRGRAQRSPAAFDSPNPRVFSSLGALDTNKVRNYGEMFRVVWGMFLHGGWMHLLLNVSCQAQTLWILEPAWGFLRTLSLWIVGGVSGSLLSAVANPCTVTVGSSGAFYGLLGALVPFSIEYWDHIASPAWFLFCVSVLVMVAQFGNMVGVQGVDNNAHLGGLIGGLLFGFATIRSVHAFRWQGVAERMASSTLFWWMFPAEKRRSLREDNLQRVAREREERSSGRIPPPKFVWKFRGHEREWCVRFAAAVGLVTFWSVLWLYLLVPSYYESLSSPPGNFSFLGSTGCHCCRVQPFPGEEDKLPAFHPVRVNRGLFWCFVSEGVANLFCGRSSALNRGADVYGQTRQFEEALGDLPSARAGEAPLRIAKEEGESASVWQRLVKSAKKTYNAVLGNTTTPAAPSAAELAQQTRAGQ", "function": "Serine protease involved in intramembrane proteolysis. Cleaves microneme adhesins, such as MIC2. This step is essential for efficient invasion of host cells. Catalyzes intramembrane proteolysis of AMA1.", "AFDB_id": "AF-Q6GV23-F1-model_v4" }, { "swissprot_id": "Q9CQI4", "sequence": "MLAQIPRPEIMDEDQLMKEVLDKFVNCHEQTYEEFLSTFTHLSKEDNVAKWGAHGTDSSENIFSTVKWNHKTESNGRHFRNTSIFLHTSSEHSEEDQIVIDEGHKVGSSFQGDMTRAGKVKVDNFLDLEDVDMEEESKPQMNKDCLLLPGEVEQDISTSVPSYDPSVDLPLTSEVRPKPAVGRTQKQTEEILGDEVQPFFLDEEFDYDNVTLTPKFTAGEIATIQELSKQKRVGSGTNVCELHD", "function": "Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.", "AFDB_id": "AF-Q9CQI4-F1-model_v4" }, { "swissprot_id": "A7XQ02", "sequence": "MKFRTLLIIFSLVFLLEIVSASEPQCGRDAGGALCHGNLCCSHWGFCGTTAIYCDVDQGCQSQCWSSPPPPSPPPPPPSPPPPSPPPPSPPPPSPPPPSPPPPSPPPPSPPPPSPPPPGGPERPDHRCGRALGNPPCNPGRCCSIHNWCGSTAAYCRGSSCQYQCWNSLLSALISNGNNAISKIISKSVFDEMFKHMKDCPSKGFYSYDAFIIATTSFPHFGTTGDITTRKRELAAFFAQTSLATTGQRFDSQDLYVWGYCHINETTNGNDNDYCTSAHWPCPSGKKYNSRGAVQLTHNYNYGLAGEALGLDLINNPDLVATDPVISFKTAIWFWMAQHDNKLSCHDILINANSGYVIGNIIKNSGYQNGLITNTISTMRGIGYYKRYCDMLGVSYGDNLDSWYDQTHFSEVARM", "function": "Chitin-binding protein which slows larval growth when consumed by the lepidopteran species S.ricini and M.brassica, but not when consumed by the mulberry specialist B.mori. Lacks chitinase activity.", "AFDB_id": "AF-A7XQ02-F1-model_v4" }, { "swissprot_id": "Q5SHW0", "sequence": "MDLPPRTGSLKWGTYPEDVLPLWVADMDFPPAEAIQQALAERARGFLGYPPREGDRELRELILEALGLEAELAFMPGVVVGLYAAVAAFTAPGQGVLTQVPIYPPFLAAIRDQRRTVLANPLRETPEGYRLDLAGLERLAFATRLLLFCHPHNPTGRVFGEEELAALAQIARRHDLIVVSDELHAPLTYEKPHVPLARFLPERTLTLVGPGKTYNLAGLPIGAVLGPKPLVEAVKRHLPHVFPNVLAMAAWKAALKEGGPWLKATLEQLRANRDRVAAWAKARGLGHHPPEGTYLAWIQTPFPKAAAYFLERARVALNPGESFGRGYDTYVRLNFATYPEVLEEALRRLDGALK", "function": "Catalyzes the transformation of cystathionine to homocysteine. Can also use cystine or S-methylcysteine as substrate.", "AFDB_id": "AF-Q5SHW0-F1-model_v4" }, { "swissprot_id": "Q9STX3", "sequence": "MKRSTTDSDLAGDAHNETNKKMKSTEEEEIGFSNLDENLVYEVLKHVDAKTLAMSSCVSKIWHKTAQDERLWELICTRHWTNIGCGQNQLRSVVLALGGFRRLHSLYLWPLSKPNPRARFGKDELKLTLSLLSIRYYEKMSFTKRPLPESK", "function": "Essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to activate the pathway.", "AFDB_id": "AF-Q9STX3-F1-model_v4" }, { "swissprot_id": "Q86SM8", "sequence": "MMEPREAGQHVGAANGAQEDVAFNLIILSLTEGLGLGGLLGNGAVLWLLSSNVYRNPFAIYLLDVACADLIFLGCHMVAIVPDLLQGRLDFPGFVQTSLATLRFFCYIVGLSLLAAVSVEQCLAALFPAWYSCRRPRHLTTCVCALTWALCLLLHLLLSGACTQFFGEPSRHLCRTLWLVAAVLLALLCCTMCGASLMLLLRVERGPQRPPPRGFPGLILLTVLLFLFCGLPFGIYWLSRNLLWYIPHYFYHFSFLMAAVHCAAKPVVYFCLGSAQGRRLPLRLVLQRALGDEAELGAVRETSRRGLVDIAA", "function": "Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.", "AFDB_id": "AF-Q86SM8-F1-model_v4" }, { "swissprot_id": "P86491", "sequence": "MSQSPRIAVVGAGLGGAAAAKLLLQEGFNVRVYEQAPSFSRLGAGIHVGPNVMKILRRIGIEDALNEQGSHPDYWYSRHWQTGDVLAQIPLGDYAVKEYGASYLTVHRGDFHALLVEALPDSVMAYGKFLTKVEDRGNVVVMHFADGTTEEADIVIGPDGVNSRIREELLGPELPKYAGYLAHRAVFPTPEVKAGMLPFDACVKWWSDDRHMMTYFVTGKADELYYVTGVPVEKWDLNDRWLESSKEEMREAFSGWHPTVQALIDATVEVTKWSLLERDPLPLWSRGRLVLLGDACHPMKPHMAQGAAMAIEDGAMLARCLKEVGAHNHELAFALYEANRAERASKVQRISHDNTWLRTNEDPSWCFGYDVFNVPLVEPKVKAAA", "function": "Flavin-dependent monooxygenase (FMO) that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway. Uses NADH in preference to NADPH as an electron donor.", "AFDB_id": "AF-P86491-F1-model_v4" }, { "swissprot_id": "Q9PT60", "sequence": "MTECFLPPASSPSEHRRAEHGGGLARTPSSEEISPTKFPGLYRTGEPLPPHDILHEPPDIVSEDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKIKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEDKHKEKKSKDLTAADVVKQWKEKKKKKKPTPEPESLPVDIPRLRPVFGIPLIEAAERTMIYDGIRLPLVFRECIDFIEQHGMKCEGIYRVSGIKSKVDELKAAYDREESPNLEDYEPYTVASLLKQYLRELPENVLTKDLMPRFEEACGKTTEGERLQECQRLLKELPECNFCLTSWLVVHMDHVIEQELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGGVQIKRVIKPLRWSNMATMPALPETQETIKEEIRRQEFLLNCLHRELQAGVKDLSKEERLWEVQRILTALKRKLREAKRQDCETKIAQEIASLSKEDVSKEEMTENEEEVLNILLAQENEILTEQEELVAMEQYLRRQIATEKEEIDRLRAEISEIQSRQQHGRSETEEYSSESESESEDEEELQYILEDLQRQNEELEIKNTHLNQAIHEEREAIIELRVQLRLLQKQRVKSEQLQEEEELGKQNVPSQLPRDNLPETKAPKDQPKALMEQMKPSPIKKTGKKLSSETLI", "function": "Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance.", "AFDB_id": "AF-Q9PT60-F1-model_v4" }, { "swissprot_id": "A0LUZ1", "sequence": "MKRSTPRPARSQAALTTSSEESPDRVERGGDGVATVTDFPDGPPDETGLTPRQRRILDVIRDSVRRRGYPPSMREIGEAVGLTSTSSVAHQLMVLQRKGFLRRDPNRPRAVEIRSAESAVPDASAGHSPAADRAPSARRPPRGPSPIDSNPDVVAVPLVGRIAAGGPALAEQLIEDVVPLPRQLVGEGTLFLLQVKGDSMVDAAICDGDWVVVRQQPVAENGDIVAAMIDGEATVKTFKRRGAHIWLMPHNPQYEPIPGDEATILGRVVAVLRRL", "function": "Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.", "AFDB_id": "AF-A0LUZ1-F1-model_v4" }, { "swissprot_id": "A0A0H3K9R3", "sequence": "MQFMGTASRMASTQRAKPMEMPRISRDTARMLVNYLTYQAVCVIRDQLAETNPAGAYRLQVFSAEFSFQDGEAYLAALLNHDRELGLRVMTVREHLAEHILDYLPEMTIAQIQEANINHRRALLERLTGLGAEPSLPETEVSDRPSDSATPDDASNASHAD", "function": "An RbcL-specific chaperone. The central cleft of the RbcX homodimer (RbcX2) binds the C-terminus of an RbcL monomer, stabilizing the C-terminus and probably preventing its reassociation with chaperonin GroEL-ES. At the same time the peripheral region of RbcX2 binds a second RbcL monomer, bridging the RbcL homodimers in the correct orientation. The RbcX2(2)-bound RbcL dimers then assemble into the RbcL8 core (RbcL8-(RbcX2)8). RbcS binding triggers the release of RbcX2.", "AFDB_id": "AF-A0A0H3K9R3-F1-model_v4" }, { "swissprot_id": "Q8CXF3", "sequence": "MDIQQNKTNKQKKKRNRFIFRSSILLILVAAVVFAIVSNMKDDNKIYRVGDAAPDFQLKQISEEVDQSTVQLSDLEGKGVMLNFWATWCDPCKAEMPYMQDLYAEYKEKGVEIVAVSLDGTELVVDQFIDEYDLTFPVPHDKNGEVKDLYKIGPMPTTYFIKPNGEIEEIVQGALTLDRLEGYLNDIAPQQN", "function": "Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached.", "AFDB_id": "AF-Q8CXF3-F1-model_v4" }, { "swissprot_id": "Q03708", "sequence": "MELKNSISDYTEAEFVQLLKEIEKENVAATDDVLDVLLEHFVKITEHPDGTDLIYYPSDNRDDSPEGIVKEIKEWRAANGKPGFKQG", "function": "This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA.", "AFDB_id": "AF-Q03708-F1-model_v4" }, { "swissprot_id": "Q9SZ70", "sequence": "MDPVQSHGSQSSLPPPFHARDFQLHLQQQQQHQQQHQQQQQQQFFLHHHQQPQRNLDQDHEQQGGSILNRSIKMDREETSDNMDNIANTNSGSEGKEMSLHGGEGGSGGGGSGEQMTRRPRGRPAGSKNKPKAPIIITRDSANALRTHVMEIGDGCDIVDCMATFARRRQRGVCVMSGTGSVTNVTIRQPGSPPGSVVSLHGRFEILSLSGSFLPPPAPPAATGLSVYLAGGQGQVVGGSVVGPLLCSGPVVVMAASFSNAAYERLPLEEDEMQTPVQGGGGGGGGGGGMGSPPMMGQQQAMAAMAAAQGLPPNLLGSVQLPPPQQNDQQYWSTGRPPY", "function": "Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).", "AFDB_id": "AF-Q9SZ70-F1-model_v4" }, { "swissprot_id": "Q5HQJ5", "sequence": "MEFNTYIGRAGTGKSTAMLNQIKNKMKQDPLGDPIVLIAPTQSTFQLEQAFVNDSELHGSLRTEVLHFERLSHRVFQEVGGLTEQRLSKAALEMMIFHIVQQHESDLKLYGSQAQYYGLSEKLAEQIQDFKKYNVTPEHLNQLIENHSIQTRTKHKLEDISLIYKQLESRMNGEFITTEDSLQQFIEILSQSQWIKKAEVFIDGFHNFSTLEYRIIEALVQHAKQVTVLLTTDGSHHPFSLFRKPSEVLSHLEDIANRLNINLNKTYFNTFYRYNNDDLKNLENGFDALQFTPKHHQNHVKIFESSSMREEINEVARRILKDVREADYKFRDIAILYRDESYAYLFESILPSYDIPFNIDTKKSMTHHPIMEMLRSLLEVIRSNWHINAMLRLFKTNVLTSQFKRSSYLIDLLENFVLERGIYGKRWLDEDIFSIDQFSRMGRKSHQLTEGHQALYKEVIKLKKNVINKVLYFEQAMNEAHTVKDYATSFYESLEYFELPSQLMTQRDELELAGLTEKAEEIDQVWNGLIQILDDLVTVFDDQEMTLQQFLDVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKKHIYMVGMNDGILPQTVSSSSLITDEEKKYVEDNAHVELSPTSDILQMDEAFVCYIAMTRSQQSVTFSYSLMGNSGDEKEISPFLTQIKELFYDLEITNLQDLHKAQPLLMMQHSHQTKIQLFEYLRGWLDHEDIDYRWLDAYLAIRDDDQLNQGLDYLTTSLTYDNETVQLNEILSQQLYGKTINASVSRFEGYQQCPFKHYASHGLRLNERTKYELQNFDLGDIFHSVLKYISDRIYGDFKNLDTKNIQSLTKEALELILPKVQFNLLNSSAYYKYLSKKIGSIVETTLKALKYQGEYSKFVPQRFETGFRKSPKNKGELVAQPLITNQGIPINIRGQIDRIDTYTKGDHSYVNIIDYKSSESSATLDLTKVYYGLQMQMMTYMDIVLQNKERLGLTDIVKPGGLLYFHVHEPRIKFKSWADIDEDQFQKDYIKNFKMSGLLNRDQEVLDALDIRLEPKYNSDIVPIALTAKGAINQRSSKVADENIIYQLIEHNKKNFIETASHIMDGHTEVAPLKYKQVLPCQFCNYKSVCHVDGLIDSKRYRTVDESIKPLDLIQQLRNEGGERHDSN", "function": "The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.", "AFDB_id": "AF-Q5HQJ5-F1-model_v4" }, { "swissprot_id": "Q9Y6B7", "sequence": "MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPLIPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETLNSFISVLETVIGTIEEIKS", "function": "Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).", "AFDB_id": "AF-Q9Y6B7-F1-model_v4" }, { "swissprot_id": "Q8N693", "sequence": "MESLRGYTHSDIGYRSLAVGEDIEEVNDEKLTVTSLMARGGEDEENTRSKPEYGTEAENNVGTEGSVPSDDQDREGGGGHEPEQQQEEPPLTKPEQQQEEPPLLELKQEQEEPPQTTVEGPQPAEGPQTAEGPQPPERKRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQRVLMLRNTATADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLPVPPMPPRPPMVPMPPRPPIAPMPPMAPVPPGSRMAPVPPGPRMAPVPPWPPMAPVPPWPPMAPVPTGPPMAPVPPGPPMARVPPGPPMARVPPGPPMAPLPPGPPMAPLPPGPPMAPLPPGPPMAPLPPRSHVPHTGLAPVHITWAPVINSYYACPFF", "function": "May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.", "AFDB_id": "AF-Q8N693-F1-model_v4" }, { "swissprot_id": "Q9FLD7", "sequence": "MKKLRSYYSNVRHHQNHHHHHHHHSNIVSSERKWIFFPLLIGSIFALFLLFLTTTLTSPTGGVRFLPFTRPVLLTGSGSSAFVESKIKPQQISSLPSPPRFAYLISGSAGDGKSLRRTLLALYHPNNRYVVHLDRESSREEREELHGYIKNSSLFRRFMNVHMIEKANLVTYRGPTMVANTLHAAAILLREGADWDWFINLSSSDYPLVTQDDLLHIFSHLPRDLNFIDHTSNIGWKASQRAKPVIIDPGLYLNKKSDVFWVTQRRSIPTAFKLFTGSAWMALSRPFVDYCIWGWDNLPRTVLMYYSNFLSSPEGYFHTVLCNAEEFRNTTVNSDLHFISWDNPPKQHPHHLTLTDMTKMVNSNAPFARKFRREDPVLDKIDDELLNRGPGMITPGGWCIGSHENGSDPCAVIGDTDVIRPGPGARRLENLVTSLLSTENFRSKQCK", "function": "Beta-glucuronosyltransferase involved in the biosynthesis of type II arabinogalactan (AG). Modifies both the beta-1,6-linked galactan and beta-1,3-linked galactan present in type II AG. Transfers glucuronate to beta-1,6-galactooligosaccharides with degrees of polymerization ranging from 3 to 11. Transfers glucuronate to beta-1,3-galactooligosaccharides with degrees of polymerization ranging from 5 to 7. The addition of glucuronate at the O6 position may terminate galactose chain extension. Required for cell elongation during seedling growth.", "AFDB_id": "AF-Q9FLD7-F1-model_v4" }, { "swissprot_id": "Q2JRH9", "sequence": "MQWLRTVAALREQVASWRGSTIGLVPTMGSLHEGHLSLIRRCRQECDHTVVSIFVNPLQFGPNEDWDRYPRDEEGDRALCEAAGVDVVFAPDPQEMGADPATAGDRTWVMPPESLLQTLCAPHRPGHFRGVATIVLQLLNLVQPQRAYFGQKDAQQLAIIQRLVQDLQIPTTIVPCPTVREADGLAYSSRNRYLSAVERQVAASLYRALRRGYDHWQAGDPSAEGILAAARAELERTPELRVQYLELVDPQTLQPLSEVKDKGLLAIAAYVGQTRLIDNLLLSPEGVDPLPQEQQSAVPPSPKRGRRPLIAIDGPAGAGKSSVARAVAAQLQLLYLDTGAMYRAITWLALQRGIPLDDAEQLTQLAAQTQLTLQSGPSADEPTRIWADGEEVTQAIRSPEVTRWVSQVAAVPGVRQELVKRQRLIGRDGGAVLEGRDIGTHVFPDAELKVFLTASVGERAQRRQHQLQAQGQVVSLEELKAQIEQRDRRDSERLISPLRPAPDAILIDTDHLSQAEVEDKIVRLYRQLLERSGAAHFDII", "function": "Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.", "AFDB_id": "AF-Q2JRH9-F1-model_v4" }, { "swissprot_id": "P72298", "sequence": "MRLKSIMCAALFVVAGQAAAQEKSITIATEGAYAPWNFSGPNGKLDGFEIDLAKVLCERMKVKCQIVAQNWDGIIPSLVAKKYDVIMAAMSVTPKRQEVISFSTPYGAHMNGFAVMKDSKLADMPGSGEVYSLNTQADAAKKRIDDVNAFLDGTTVGVQGSTTGSQFLENYFKNSVDIKEYKTVEEFNIDLMSGRVDAVFASATVLTAAFEQPDMKDAKVVGPLFSGDELGKVAVGLRKDDAALKAEFRLGAVGLRKEDAALKADFDSSIKAVADEGTIKTLSSKWFKVDVTPH", "function": "Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.", "AFDB_id": "AF-P72298-F1-model_v4" }, { "swissprot_id": "B0S2N7", "sequence": "MSAVLVSKENNQAVFTCEIPAEDFNNAIEESYKKNRSRFSLKGFRKGKVPRKMLERAYGEGLFYEDAVNLLLPGIYEKAIEELELEPVSQPDIDLDDITENNDVKVKFTVDLKPEFELGDYSKLSAEIEEFKVTDSDVDMKVNHELESNARVQEVEGREAKENDTVSINFKGFVDDKAFDGGEAEDYELVLGSHTFIPGFEEQIVGHNAGDEFDVNVKFPEDYHEDSLKGKDAKFECKINSIKEKVLPELDDEFVKDVSEFDTLDEYKKDIKEHLEKDNEQRQLVEKQNKAVEALIEATEISVPESMIDNEVNRQFQDFARRVQQMGLNTDQYFQITNTSEEDVKNELRANAELKVKGDLVLEKYIEKEAIESTDEELDEQLKEFAKVYGKDDEEKFIEEFKNSPNVEFLKEDIKRKKALEKLVENTKFEIKKAEEKEDK", "function": "Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.", "AFDB_id": "AF-B0S2N7-F1-model_v4" }, { "swissprot_id": "Q9ZJ31", "sequence": "MKKLKGLFLSLLLWVYPLKSEPINEGAYILEEIGDVLRFLPIFVGTVSLAMRDYRGLGELAVGTLVTQGVIYGLKGAFSTAHKDGARVGFAKRPCCNSWRGMPSGHAGGAFSAAGFVYYRYGWKPALPVIALAILTDTSRVVAGQHTILQVTIGSLIAWGFAYLFTSRYKPKRWMLYPEISSDFKGSSRYGVGFSYQW", "function": "Removes the 4'-phosphate group from tetra- and hexaacylated lipid A species, has no 1-phosphatase or Kdo hydrolase activity. Absence of the 4'-phosphate group renders the bacteria resistant to host-derived cationic antimicrobial peptides (CAMP), allowing it to camouflage itself from the host innate immune response, and plays a critical role in the long-term colonization of the host's stomach.", "AFDB_id": "AF-Q9ZJ31-F1-model_v4" }, { "swissprot_id": "O95900", "sequence": "MGSAGLSRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLGPMEGSEEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERGAGQ", "function": "Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs.", "AFDB_id": "AF-O95900-F1-model_v4" }, { "swissprot_id": "P38167", "sequence": "MPFITSRPVAKNSSHSLSETDLNQSKGQPFQPSPTKKLGSMQQRRRSSTIRHALSSLLGGANVHSPAVLNNTTKGGNNNGNIRSSNTDAQLLGKKQNKQPPPNARRHSTTAIQGSISDSATTTPRSSTSDTNRRTSGRLSVDQEPRISGGRYSQIEEDSTVLDFDDDHNSSAVVSSDLSSTSLTRLANSKKFNEQFLIEYLTARGLLGPKTVLSNEYLKISISTSGESVFLPTISSNDDEYLSRLNGLNDGTDDAEADFFMDGIDQQEGNTPSLATTAAATESGGSINENRDTLLRENNSGDHPGSGSELNTRSVEIDSSMVSYSIAVIVSVKKPTRFTDMQLELCSRVKVFWNTGVPPTKTFNEEFYNAASMKWNLNDENFDLFVPLSISPDDQMIENNSNDRQMRLFKNIPTEERLYLDKTKTKASLLNAIDVNKTHLYQPGDYVFLVPVVFSNHIPETIYLPSARVSYRLRLATKAINRKGFYRQDSNSPQPIVSPDSSSSLSSTTSSLKLTETESAQAHRRISNTLFSKVKNHLHMSSHQLKNEESGEEDIFAEYPIKVIRTPPPVAVSTANKPIYINRVWTDSLSYEISFAQKYVSLNSEVPIKIKLAPICKNVCVKRIHVSITERVTFVSKGYEYEYDQTDPVAKDPYNPYYLDFASKRRKERSVSLFEIRTKEKGTRALREEIVENSFNDNLLSYSPFDDDSDSKGNPKERLGITEPIIIETKLKFPKYEDLDKRTAKIIPPYGIDAYTSIPNPEHAVANGPSHRRPSVIGFLSGHKGSKSHEENEKPVYDPKFHQTIIKSNSGLPVKTHTRLNTPKRGLYLDSLHFSNVYCRHKLEIMLRISKPDPECPSKLRHYEVLIDTPIFLVSEQCNSGNMELPTYDMATMEGKGNQVPLSMNSDFFGNTCPPPPTFEEAISVPASPIVSPMGSPNIMASYDPDLLSIQQLNLSRTTSVSGPSGYSDDAGVPNVNRNSISNANAMNGSISNSAFVSGNSGQGVARARATSVNDRSRFNNLDKLLSTPSPVNRSHNSSPTNGLSQANGTVRIPNATTENSKDKQNEFFKKGYTLANVKDDEEQEGIVSSSSADSLLSHGNEPPRYDEIVPLMSDEE", "function": "May be involved in cell wall organization and biogenesis.", "AFDB_id": "AF-P38167-F1-model_v4" }, { "swissprot_id": "Q6MQ47", "sequence": "MSYSRERLQRAQEAMGIAAKKSLGQNFLVSDTVINRIIDQVKAFAPEELVEVGPGPGALTDLLLELNLPLQLIELDSAIAAYWREKGLTVIEQDALRLDWKQFYTGKRVVFVSNLPYQISSSIVIERSLENEGVAAMVLMFQKEVAQKIRGTVDSDLYGLLSVYAQAFWKIETVTDAGPRDFQPPPKVASRVLSFERIESEVKNRKAFLTFVKCAFAQRRKLLKKNLSGLLSQKKLTEEQMVGWLAELGFKETARAEELSPKQFVALYKHFGFE", "function": "Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.", "AFDB_id": "AF-Q6MQ47-F1-model_v4" }, { "swissprot_id": "Q9CWX2", "sequence": "MSSIHKLLTGIYIHKNFLRPRAALPPFVGNHCVDYSSSSLQKKVTSVDRASQQGKTEEGLQGHDHKEVALDAPSPDRTPEVSFDKAIRDEAIEHFRRLKDEIVAHLRGPDGRPLQEVIMEQARVVWQFREKEDLDKWIVTSDKTIGGRSEIFLKMSKNNRSALLYGTLSSEPPQDGDSRQSGYCAMISRIPRGAFERKLSYDWSQFNTLYLRVRGDGRPWMVNIRQDTEFIQRKNQMYSYFMFTRGGPYWQEVKIPFSKFFFSNQGRVRDVQGPLVLDKISSIGFTLSDKVDGPFFLEIDFIGVFTDPAHTEEFAYENSPVLNPRLFR", "function": "As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.", "AFDB_id": "AF-Q9CWX2-F1-model_v4" }, { "swissprot_id": "Q1INT8", "sequence": "MNPPVEANIRKTALNATHRQSGAKMVDYSGWDMPVEYPSVGGLMKEHLAVRAGVGLFDVSHMGDIRVHGPEALKAVQYLTMNDASKLNTGQAQYSAMLYPNGTFVDDVIVHKFADDDYLLVINAGTREKDVNWVKDNTRQFKVTVEDLSDQFTQIAIQGPKGVDTLQKLTDVDLSKVKFYWFTRGTVAGLKNVLIARTGYTAEDGFEIYIPSDAATSDRVWNELLQAGKEFGVVPAGLGSRNTLRLEGKLPLYGHEISDEINVWEAGLDRFLKMDKGDFIGRAALEKAKNDGVKRALVGLETIERGIPRDGYKVLDLEGKEIGYVTSGSYMPFLKRNLALAYVPVEQSALDNIVAVEIRNQPVKAKVVPSQFYKRPKKSS", "function": "The glycine cleavage system catalyzes the degradation of glycine.", "AFDB_id": "AF-Q1INT8-F1-model_v4" }, { "swissprot_id": "W6R4D7", "sequence": "MMFHFLGTAGLGIALSWLVFTHFLQSSCRCQPWEPCWPSDEQWELLNRSMEFTLVRLQPIASVCYNHSLDHTLCEDVMRMSRDSGWRASQPGALQDWVWESGQSPGDACPLGSQMNGHTQCHQGRIPLYSAMVNSTKHVQEAVMFAKRHDLRLIIRNTGHDLAGRSSSPNALQIHTHRLQDIKFHDNVQLHGFEKSFGPAVSVGAGVMMGDLYARSAQNGYIVVGGDCPTVGVVGGFLQGGGISDFLSLHHGLAVDNVLEFEVVTASVSLPEPDAIQYCGFLTLRQGDIVLANAIRNPDLFWALRGGGGGTFGIVTRATMRVFPDVPAIAAELGVQTSQSHGEYSRSLAAFFTVLQSLNRENVGGQLIITVISEHSIEAKLKMFFLNQTNTADVDQRMQPFVEDMRRIETHVTYESTSLPKLSMNYRQVPDIHTDNDYGVLGSTVAISNDLFNASKGPAYVADGLAQLPTRPGDLLFTSNLGGQVMRNGDLMETSMHPAWRNATQLINFVRPVEPTIEGKAGALQNLTNIHMPLLYAIDPRFRLSYRNVGDPNEKDFQQVYWGQSYARLLQLKRRWDREGLLISKLGVGSEEWDSEGMCRTGRRSLENLAIDTLSSLAHLIHVTYRCIW", "function": "FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids. The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan. The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde. The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline. The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine. Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A. Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2. The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions.", "AFDB_id": "AF-W6R4D7-F1-model_v4" }, { "swissprot_id": "Q9RUE8", "sequence": "MKKFAAVLGLTVAFAAASQAHAVTLTFACDSVGQGFDECKKGADAWAKKTGNTVKLVQVPKESDARLALYQQQLGAKASDVDVYMIDVVWPGLIGQHLMDLSKSIPAAEVKAHFPAIVQNNTVGGKLIAMPWFTDAGVLYYRTDLLKKYGYNAPPKTWNELATMAQKIQAGERKSNPKFVGYVFQGKNYEGLTCDALEWISSFGGGSIVDPSGKITVNNPKAVQALQAIQGLIGTAAPAAVTTYGEEEARNVWQAGNSAFMRNWPYAYAAGQKEGSPIAGKIGVAALPAGPGGKPAATLGGWQLAVNAYSKNPKEAADLVRYLTGAQEQKRRAVQASYNPTIATLYKDKDVLKAVPFFGSLYDVFTNAVARPATVTGSKYNQVSDAFSSAVYSVLTKKSAPGPALKTLEGQLARIKGRGW", "function": "Probably part of a binding-protein-dependent transport system.", "AFDB_id": "AF-Q9RUE8-F1-model_v4" }, { "swissprot_id": "Q2VF17", "sequence": "MWKILETCSCFLVVAVLSGLGKAQPESFSGSAVTDDSTSGANKRGWSMLRLGRGLQMLRLGKRGGSLDALRSGHQVPMLRAGRGSPDTSGRLDANELYAVLSAILDEPRDQSRRQPPLPRYGRDNNGVARDLLDALASDGESSSNFDLLSSLNNGPSYFRPAPRGGRYKRSLPDAGPADYPSLEDYLVQSRQFARPYSSRAVALPRIGRFSGSPRLQAKAVPRPRIGRQESQMREAKSAE", "function": "MMG2-DPs (Myomodulin gene 2-derived peptides) bias egestive feeding programs toward ingestive ones, and modulate accessory radula closer (ARC) muscle contractions.", "AFDB_id": "AF-Q2VF17-F1-model_v4" }, { "swissprot_id": "Q607V0", "sequence": "MSLARTLARRAAVQAVYQWQLARDSLPDIERQFVEELQLAKSLYRRHAEGFELSPPEREQLEELLEKFGRSQGTDEVEEEDVTLEQRASQCQVPDVQVGYFKELLHGVANNLALLDAALAKYLDRPIDEVDPVERAILRIGCYEFMRRPETPYRVILNEAINLAKEFGAAQSYRYVNGILDRVAHECRAVEMAARRRG", "function": "Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.", "AFDB_id": "AF-Q607V0-F1-model_v4" }, { "swissprot_id": "Q8BP27", "sequence": "MAEEGNQEFTSKMENSSDSASTSPDAPQPSENPPSPPTSPAAPQTSENPPSPPTSPAVPQTRENPPSPPTSPAAPQPRENPPSPPTSPAAPQPRENPPSPPTSPAAPQPRENPPSPHSNSSGKQPLSGTPKERLKKARSSSHSFCSVVKRMKVENDENNETLSEPGESSKEENCSKAQESLKNKDSEPGEKSSEEKNTCESKSSDTGSSNALPKESENAIIREKLKQEKIRLIRQVEEKEDLLRRLKLVKMYRIKNDVTELENLIKKWRKCGQRLLCELQSIMSEDEDEKLTLTELIDFYGIDDNLLHYNRSEEEFTGV", "function": "Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcriptional modulator for ESR1.", "AFDB_id": "AF-Q8BP27-F1-model_v4" }, { "swissprot_id": "Q9HDY7", "sequence": "MCNRQPKAVDLPPNYSCPHLLSFQSVEFNTNPTACDDVFCKRIESEKKYNDFLESLFKKYGRDTSDIADEVDLATGEIIVNNGHLEALKTKDDIWDPTFNNLEISASNGYEKKLDSSIGNPGEKAVSPVHIEDFQSPQIYKFKNLSLRDEMVSDCVFADEVPLASLFVENVCNETIPSQSCVRLKINDKTRKVDASALEKKSCLLPNSSGTLTDQRGLDTIKHKSIEQNEILHVISDTLSSPRRRNPLLSSPKTPLRRSFSKSKVRNSNSTKRRNFISLISMISPRPNLSTHHFNLGFQPLSQQTSFSGSSTQNPHSSSTCKKAFCFQCISESKKC", "function": "Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres.", "AFDB_id": "AF-Q9HDY7-F1-model_v4" }, { "swissprot_id": "A2ARP9", "sequence": "MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK", "function": "Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.", "AFDB_id": "AF-A2ARP9-F1-model_v4" }, { "swissprot_id": "B8BVM7", "sequence": "MKFTAACILLSATAASAFSPVARFTFSRPTTTSLHAEVTTALIKELREATGAGMMDCKKALTEFDGDIEAAADELRKKGLAKADKKASRIAAEGKIAVASAGGKTVLVEVNCETDFVAKDESFAKFADEAAAAAAAMDGDSVEALMAANGNALEDARAGLVSKIGENIQVRRVATRGSGATTTGAYVHMNRIGVLVEIEGGTEALCTDVAMHVAAMNPAYATQEDVPAADIEKERAFLTAQVEDSGKPADIVAKMVEGRLQKFLAENCLVSQTYVKTNDRTVAKLLEENGAKMIGFTRIAVGEGIEKKVDDFAAEVAAMAGGGKAAPAPKAEEPAAVAPAKADAEDSAEAHKLSVITYP", "function": "Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.", "AFDB_id": "AF-B8BVM7-F1-model_v4" }, { "swissprot_id": "P0AFV2", "sequence": "MTAEFIIRLILAAIACGAIGMERQMRGKGAGLRTHVLIGMGSALFMIVSKYGFADVLSLDHVGLDPSRIAAQVVTGVGFIGAGNILVRNQNIVGLTTAADIWVTAAIGMVIGSGMYELGIYGSVMTLLVLEVFHQLTFRLMNKNYHLQLTLVNGNTVSMLDWFKQQKIKTDLVSLQENEDHEVVAIDIQLHATTSIEDLLRLLKGMAGVKGVSIS", "function": "Could be involved in magnesium uptake.", "AFDB_id": "AF-P0AFV2-F1-model_v4" }, { "swissprot_id": "Q00017", "sequence": "MKTAALAPLFFLPSALATTVYLAGDSTMAKNGGGSGTNGWGEYLASYLSATVVNDAVAGRSARSYTREGRFENIADVVTAGDYVIVEFGHNDGGSLSTDNGRTDCSGTGAEVCYSVYDGVNETILTFPAYLENAAKLFTAKGAKVILSSQTPNNPWETGTFVNSPTRFVEYAELAAEVAGVEYVDHWSYVDSIYETLGNATVNSYFPIDHTHTSPAGAEVVAEAFLKAVVCTGTSLKSVLTTTSFEGTCL", "function": "Plays a key role in the degradation of rhamnogalacturonan in the cell wall. Acts in synergy together with rhamnogalacturonase A (RGase A) and rhamnogalacturonase B (RGase B).", "AFDB_id": "AF-Q00017-F1-model_v4" }, { "swissprot_id": "Q9VV73", "sequence": "MPNQMRVLDFGDGSVPIQLDYPDSKIFSKCSSYGDRVPGTHWNEITVHHKGRLEYSPNPEQIILDALYQAIDGADFFPVFYQRGKNMDTMLVRNCKAAIDKLFKQRLSINLKGGASIPISIQLGVAQYQRHQITPTFHIARVVTRLMKQLIQRDGVDGLLNLDNFGSHPEFKNLVVSLGNPSILMNVCQVIHNDDNERFRLNGFILSNNRIRDIRPLTLLANVDYALLDLRGNKIKSAERLCRALEQFRARELLLENNPIVKISNFPANIKSLESNFELVDGKPFNMLHKIFSPLDVEIDLEVDGARIDTNNMWKLPEFENSQHWHAFMIPDPSHEFNQEVFFDFFFIRLDPTLSNFYPCYYKYINTEHVFLVRNCFDQIAHLVNNCNLEMTIPTGDRIFRYYLRMNVSTVKQHHVDPEECIQKAVSQCYVAQNRMLNLERFHSRECLKDVMVSLSSPKILTYVLSVASRKFMTTCSEIRLCHNKVLVLDGAHVLGMMGCLRAVDLSHNWVQDLSSIHSLGNLPLKSLVLHGNKLCRNYRLPSEYVRAVKEVFPQLTTLDGVDLQTNPGQSLQKNFLCDTGAYELVGAFLENYLREFENDEFRHNLYKYYSENSIFTLTCNYNVVQNHQTPKILQRLSKYNRHARNLRNKDYSKASDGVFFGCTYIVEILLQLPRVTHDFHSLQTDVMHYNGKGAVIYVAGLLRDEPPSTRNGHGSKTDIGGVLLGFSRQFVVTFDEANLGLGKRARRLKIANERLHITNPSKTAIRNAFSVNFPDPSERQAEEDSLDVKDHKLLLFQEVTGLISTWVTSIVEEADWDFERALKLFIQKNADHEIPDLAFA", "function": "May be involved in the export of mRNA from the nucleus to the cytoplasm. In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing. On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci. Does not affect piRNA biogenesis. The interaction with Panx stabilizes the nuclear protein complex. Does not bind nucleoporins, but regulates sbr/Nxf1 binding to nucleoporins and, indirectly, transposon exports.", "AFDB_id": "AF-Q9VV73-F1-model_v4" }, { "swissprot_id": "O23404", "sequence": "MLYIRKKMTSMIVKTTPELFKGNGVFRTDHLGENRMVSRSNRLGDGSNRFPRTGTIHCQRLSIAKTGLHRETKARAILSPVSDPAASIAQKRVFTFGKGRSEGNKGMKSLLGGKGANLAEMASIGLSVPPGLTISTEACQQYQIAGKKLPEGLWEEILEGLSFIERDIGASLADPSKPLLLSVRSGAAISMPGMMDTVLNLGLNDQVVVGLAAKSGERFAYDSFRRFLDMFGDVVMGIPHAKFEEKLERMKERKGVKNDTDLSAADLKELVEQYKSVYLEAKGQEFPSDPKKQLELAIEAVFDSWDSPRANKYRSINQITGLKGTAVNIQCMVFGNMGDTSGTGVLFTRNPSTGEKKLYGEFLVNAQGEDVVAGIRTPEDLDTMKRFMPEAYAELVENCNILERHYKDMMDIEFTVQEERLWMLQCRAGKRTGKGAVKIAVDMVGEGLVEKSSAIKMVEPQHLDQLLHPQFHDPSGYREKVVAKGLPASPGAAVGQVVFTAEEAEAWHSQGKTVILVRTETSPDDVGGMHAAEGILTARGGMTSHAAVVARGWGKCCIAGCSEIRVDENHKVLLIGDLTINEGEWISMNGSTGEVILGKQALAPPALSPDLETFMSWADAIRRLKVMANADTPEDAIAARKNGAQGIGLCRTEHMFFGADRIKAVRKMIMAVTTEQRKASLDILLPYQRSDFEGIFRAMDGLPVTIRLLDPPLHEFLPEGDLDNIVHELAEETGVKEDEVLSRIEKLSEVNPMLGFRGCRLGISYPELTEMQARAIFEAAASMQDQGVTVIPEIMVPLVGTPQELGHQVDVIRKVAKKVFAEKGHTVSYKVGTMIEIPRAALIADEIAKEAEFFSFGTNDLTQMTFGYSRDDVGKFLPIYLAKGILQHDPFEVLDQQGVGQLIKMATEKGRAARPSLKVGICGEHGGDPSSVGFFAEAGLDYVSCSPFRVPIARLAAAQVVVA", "function": "Formation of phosphoenolpyruvate. May be involved in regulating the flux of carbon into starch and fatty acids of seeds and in the remobilization of nitrogen reserves in senescing leaves.", "AFDB_id": "AF-O23404-F1-model_v4" }, { "swissprot_id": "Q15NP1", "sequence": "MSEQANALLLDIGNSFIKSAHVKISERVFEQPLIVTRCNEVSKLREQIKASQRVVAAAVGQGQQVKLLESLCAELHVPLILAKSQAQAFSMRCAYRNFSTLGVDRWLAVIAARRISNTDAYCVIDLGTANTCDVVIGHQHLGGWIAPGFSLMRDSLIKNTELVFANDDFPNDLTLGEQTVDCVNMGCAAAVNGFIYAAEQKMRERKSEYTVIITGGGQELIKKNAPKHYYFHKNLVLLGLLEYLFT", "function": "Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.", "AFDB_id": "AF-Q15NP1-F1-model_v4" }, { "swissprot_id": "Q5BUB4", "sequence": "MNLSRFAPSPSSDSLISTLRPRAAVRRLHSNITGPMTPFKTAVNAYVASEGTDNSYVVRPRLYNDKRAQSDGSNALLSSIGPSGTTKRPRDEMDCFTDTHKHKRGDGNKSRRREQCRANQARYRDKQRNAQQQLERSVEQLQSELSTLKHRNLDLASRQRTNQSPWNTVAEVFRLLGVCFRSPWRVTCVQEMRNHSEMRQILAILERSFTHDVAMGDLRGIDALMEQLLQFSQY", "function": "Required for normal zoospore movement, formation of appressoria by germinated zoospore cysts and plant infection.", "AFDB_id": "AF-Q5BUB4-F1-model_v4" }, { "swissprot_id": "Q9SHJ5", "sequence": "MVLPELLVILAEWVLYRLLAKSCYRAARKLRGYGFQLKNLLSLSKTQSLHNNSQHHLHNHHQQNHPNQTLQDSLDPLFPSLTKYQELLLDKNRACSVSSDHYRDTFFCDIDGVLLRQHSSKHFHTFFPYFMLVAFEGGSIIRAILLLLSCSFLWTLQQETKLRVLSFITFSGLRVKDMDNVSRSVLPKFFLENLNIQVYDIWARTEYSKVVFTSLPQVLVERFLREHLNADDVIGTKLQEIKVMGRKFYTGLASGSGFVLKHKSAEDYFFDSKKKPALGIGSSSSPQDHIFISICKEAYFWNEEESMSKNNALPRERYPKPLIFHDGRLAFLPTPLATLAMFIWLPIGFLLAVFRISVGVFLPYHVANFLASMSGVRITFKTHNLNNGRPEKGNSGVLYVCNHRTLLDPVFLTTSLGKPLTAVTYSLSKFSEFIAPLKTVSLKRDRKKDGEAMQRLLSKGDLVVCPEGTTCREPYLLRFSPLFAELTEDIVPVAVDARVSMFYGTTASGLKCLDPIFFLMNPRPVYCLEILKKLPKEMTCAGGKSSFEVANFIQGELARVLGFECTNLTRRDKYLVLAGNEGIVR", "function": "Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Involved in pollen development, by being required for tapetum differentiation and male fertility. In addition to the sporophytic effect, it also exerts a gametophytic effect on pollen performance.", "AFDB_id": "AF-Q9SHJ5-F1-model_v4" }, { "swissprot_id": "Q9USP3", "sequence": "MRILGSLPNNIRKCTFKLILQKRYSHTDILKELLYDISDSQKFIPSASPIASNLLRVSSYGKLSSLFIEYSKARSKKEFDQLRTSDFQSILRSVVCPKNGKNIRHRDRDLVSLQIKLILQDADRLGIQFNIVDYTHILRVAMYTGNKHILEYIVARVKEKRIRPSVDYFNAILGVIGGNRWSLSKFQSPAFRGSPVTEPVSGKMLDMIEVDFPNYDLVPNSTTYDYLMVGLSRDGKIREIYDLIDTVWGINENSSSKKVDCGNVTFPTHHTVFSIISALGYLGDVSSAVSLSRKLTSVYKINFPELAWRYIIYWSIASLQFRAPAGHARIKNIELFIRLYSQMYRHCVPIIEIYDTSIKFYMKHGRFGLLEKVCESWTKQFLGSLEKQNNEVKKKHLQLLEKQISKLMRYAETERPHDTKRVSVKWSNVLNQIHSSVGDPAKP", "function": "Mitochondrial RNA-binding protein required for the stability of the atp9 mRNA.", "AFDB_id": "AF-Q9USP3-F1-model_v4" }, { "swissprot_id": "Q0AC83", "sequence": "MRRLIPIAITGSLLWGAAVQAQGPTAAEREAYFAERQRALCGPPLVMPLDAVDTALRHRPETPATVDADAIYYDGAAGRYRFRGDVLMQRLDQRLRSEEVRYDHASGRVDLPFPFVYEEAGLALTGESGWLQLREDRGEVVAGEFMLDERNIRGRAERLELADAQRSRYEDVGYTTCRPGNEDWWLQARELELDREEGLGTARHAWFTFLNVPLFYTPWITFPIDDRRRTGLLAPGFATSDRHGTDITVPVYWNIAPNYDATLVPRWIERRGALLGGEFRYLQEAFSGELYGEYLPNDSLARDDRWLLGIDHRGRLPRGWRYDADINRASDGDYLRDFGSGLLETSSSHLQSRGRLRNRWNDWAVAAEVQHWQTLDDDLRNPYRREPRLTADYQGPFRAGQPRYRLNTEYTRFALPDTDADRPEGERMDIAPRVEWRLHRPWGYLTPAAALRHTQYRLDDPVPGADDRSPRRTVPTFSVDSGLFFDRPFDWDGRPMVQTLEPRVFYVYTPERRQDDLPVFDTSRRDFFFDGLFREDRFSGADRVGDADQVTVALTTRFVDLGGGREWLRASLGQIHYRRDRQVTLFPETDRAADRRSRSDYMAEMRSELPGGVLAQGEYRYNPYDSRSEQGAFRLGWHPRPDLLVGAGYRMRYGDEGRDVEQSDLAAVIPLGPRFSLIGRWLYSLADDNSLETVGGLEYRTCCWRVRAMGRRSFEGAGAEPDTSIMLQFEFTGLGQVDSGSTDFLQDSIYGYEGDRF", "function": "Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.", "AFDB_id": "AF-Q0AC83-F1-model_v4" }, { "swissprot_id": "A6ZMM3", "sequence": "MDNTTNINTNERSSNTDFSSAPNIKGLNSHTQLQFDADSRVFVSDAMAKNSKQLLYAHIYNYLIKNNYWNSAAKFLSEADLPLSRINGSASGEKTSLNASLKQGLMDIASKGGIVSEDGLLPSKMLMDANDTFLLEWWEIFQSLFNGDLESGYQQDHNPLRERIIPILPANSKSNMPSHFSNLPPNVIPPTQNSFPVSEESFRPNGDGSNFNLNDPTNRNVSERFLSRTSGVYDKQNSANFTPDTAINSDIAGQQYATINLHKHFNDLQSPAQPQQSSQQQIQQPQRQPQHQQQQQQQQQQQQQQQQQQQQQQQTPYPIVNPQMVPHIPSENSHSTGLMPSVPPTNQQFNAQTQSSMFSDQQRFFQYQLHHQNQGQAPSFQQSQSGRFDDMNAMKMFFQQQALQQNSLQQNLGNQNYQSNTRNNTAEETTPTNDNNANGNSLLQEHIRARFNKMKTIPQQMKNQNTVANPVVSDITSQQQYMHMMMQRMAANQQLQNSAFPPDTNRIAPANNAMPLQPGNMGPPVIENPGMRQTNPSGQNPMINMQPLYQNVSSAMHAFAPQQQFHLPQHYKTNTSVPQNDSTSVFPLPNNNNNNNNNNNNNNNSNNSNNNNNNNNSNNTPTVSQPSSKRTSSSSTTPNITTTIQPKRKQRVGKTKTKESRKVAAAQKVMKSKKLEQNGDSAATNFINVTPKDSGGKGTVKVQNSNSQQQLNGSFSMDTETFDIFNIGDFSPDLMDS", "function": "Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.", "AFDB_id": "AF-A6ZMM3-F1-model_v4" }, { "swissprot_id": "P0DJH1", "sequence": "MKYPRSLSWEKISSSTISIREFNRFENKKKVAIFCGYVRDKYEFNYHDRTYQWLRNNDYYVILVMPKSGILLESDLCKACDVFIERENFGYDFGSYACGLQYVNLIEGSERIDRLLFVNDSFIGPFGYCNLIEDSSEFWGNTDSNQVKYHYQSYLFGFNLEKVNLDIINNFFFSRGDIYTDDKSLVIENFELSLYEYFNGKGLRCSVLHPISVLKSDFIKQTFHFISYPYLTSKIFFYIMVIARDVNPTHQLWLQLFKRGFPFIKKELLRDNPTGYPELYKKVEEVMGSNDFNGEYKQIFKNHL", "function": "Could be involved in the biosynthesis of a major surface antigen important for virulence.", "AFDB_id": "AF-P0DJH1-F1-model_v4" }, { "swissprot_id": "A4ISU3", "sequence": "MGVVHDVWVVTKQLLEATALPWPAEERETWLSQVDELLRRRERLLHKLRPPYSEEEQRLGREIVAWNQEIEARLRQVRDEIRDDLRMAGAKRQANAHYVHPYEQPLSFDGMFYDKRR", "function": "May act as an export chaperone for the filament capping protein FliD.", "AFDB_id": "AF-A4ISU3-F1-model_v4" }, { "swissprot_id": "Q9LZF7", "sequence": "MVSHEENTSIVEWFLGPHPYTYPPYGIEMIHEDDEVAVAHHHHHHQSGEYYREYEDHRSSDVDNDEIIARTLQDDFLQLEIAESNDYSHQNQQQQHQQEGYTNNYSNNNNGYAWNDQSPAVDYSSEWIGNDNDQDGRSDDSVNVFSCSSPSDTDEYVYSWESDQCDADGEFGRRLNQMVPIPYIPKINGEIPPEEEAVSDHERLRNRLEMFDFTEVKVPGDGNCQFRALADQLYKTADRHKHVRRQIVKQLKSRPDSYQGYVPMDFSDYLRKMSRSGEWGDHVTLQAAADAYRVKIVVLTSFKDTCYIEILPTSQESKGVIFLSFWAEVHYNAIYLNRDTSETELQRKRKWWRFGN", "function": "Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (Probable). Cysteine protease with a preference for 'Lys-63' over 'Lys-48' over 'Met-1' -linked ubiquitin (UB) tetramers as substrates. Cleaves also RUB-GST fusion.", "AFDB_id": "AF-Q9LZF7-F1-model_v4" }, { "swissprot_id": "O94483", "sequence": "MRRSTIVPTSRTSSSSPSPSQMKSFQMNRLVDQLSKLQSNMSHLENHLHVTAIQAEAIRRLGALQASLLMASGRVMSEARIQKSSDAVEEDVPM", "function": "May play a role in the progression of mitosis in an environment of high osmotic stress.", "AFDB_id": "AF-O94483-F1-model_v4" }, { "swissprot_id": "Q27365", "sequence": "MLAPAAPAKDVVSADEKEEIIAKRKFRMKNVDAMRMSSLANDRMAFNKKCNALAMKFVKSAGIGTDALQLTCFQELVRHFNPIAAVVVGVKREPNSNVQAEKKTIPKVKTIQTPTQSMESVRLLQEKKASATEEQSAESASIMKHFANTIPNSTPTQSVKDVLTAAASKGQFKSSAEIFSHFPSEPSPSKPRATREGSQPSDYTYCTYLTPCILCEKALLMRESIAMTDNEAVKVLMAAVMSGHFRMATAEKAIRHERLRMCYDHVDFVYEMMCDAFEAKTESEINEMPPDRLMRGHDIYRALKRVGDLHKGKVTSNTPLYSFKNSIKSYYRNHVPRMVNGSLSKPSPKPFSELVALLQSVPPSTNLNELLNHNLSLSDADKQELIQLINGKDNRFTSRRRKIEDILDNKFAAAAAKAYRDHSEDAPSEPYIPNQSEMQNTVERRKRKLHSPEQDDAGSSSISWNAKKTKTPIDYVHLATRVLEGHSIADEALLHKSKVSYARNAFGEKPSSPTPPSAPLKFCVVNGKKYLRFENGTGPPKVVVQGNVVLRTNTLKDALTTAPRAQNQPSTSTDSSSSSEMEGIRQSFGAPQKEEEEEELVPTLLQNKPTHVESSSPVEKKPPTKTNVEKPAVRLGRMLTTAFGSMSYRTRKSVENKTDLLNQPTSASPRRMIKVVRNRNPHLAKQVAAAPSEPKHIPPTHMEKKPEELLMDPKPEPIF", "function": "Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56.", "AFDB_id": "AF-Q27365-F1-model_v4" }, { "swissprot_id": "Q9VTW2", "sequence": "MQHSSAGSEERITSSTSSPRSGHKTASSLFGLLSKRPSKVEPHPVTPESPRLQQRPVSACGQYDVSFAKCNADTSANHVNNNGSTLKSQTLPLEKSHSGLISFHRRAKPSSSKGKNHSHRHSTDAGSQSDGGADVVMRRKSPKHRSPNHNRFSHQFSLCCKAEKKPMTPPVTVRYNSIPDSNSVLRRDNLSLSWSMVDNNSGSLHSSEGSSHRPRPSSECASAPESPVASKTFFAHCSPAAASASVARSESLQNRSPIRPMAVSACRSRLRLKLYPPGQELPPLQAATEPGDIKRATTPQHMSSPNIATQPDGIEHIEEQPGVRFMSHENMTLQRQGSGSNLARQTLMAAHALNLIPADNARERSYLDGRLGSTSLLGPSELSRVLPQKEITVFVGTWNMNGHSPPKQLNDFVLPANVEHVPDIVVMGTQESTPDRFEWEVTIQETLGPSHVLFHATTLGTLHLAVYMRRDLIWYCSVPEDASMSVRTGSAFRTKGAVAISFCLFGTSMLFVTSHLTAHQQKVKERVSDVKRIINALDLPRNLPNQRHKNKDVTQNFDNVFWCGDLNFRLGEPREKLLEWIQNTKFPLPSHLPHGYMHTDQLTSVLADGAAFRGFMEANITFPPTYKYDPGSQNFDTSSKQRAPAYTDRILYKYRQMQGLVIRRQTLVPGVSTPTQPHVQCLLYDSVPSITTSDHKPVWALFRTLIRAGTDAIPLAAGLFSRDIYLEGMRRRLNNQYSGASAVCVLQ", "function": "Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to phosphatidylinositol 4-phosphate (PI-4-P). By controlling the phosphoinositide composition of the cilia membrane of auditory receptor neurons, regulates the cilia localization of ktub and consequently the transient receptor potential channels iav and nompC.", "AFDB_id": "AF-Q9VTW2-F1-model_v4" }, { "swissprot_id": "P50276", "sequence": "MSEGRTFLSQLNVFNKENYQFSSSTTKKEVSNSTVDADNGASDFEAGQQFATELDQGEKQLGILSCIGLICNRMLGTGVFAVSSTIYTLCGSVGLALIMWAVGAIIAISGLYVYMEFGTAIPKNGGEKNYLEAIFRKPKFFITCMYAAYIFFLGWAAGNSINTAIMFLTAADTEVTKWNQRGIGVAVVFFAFLINSLNVKIGLYLQNILGIFKIGIVLFISITGWVALGGGLKDGYQSHNFRNAFEGTETATAYGIVNALYSVIWSFVGYSNVNYALGEVKNPVRTLKIAGPTSMVFLAIIYIFVNIAYFAVVPKDKLISSKLILAADFFDIVFGGQAKRAAAALVGLSALGNVLSVIFSQGRIIQQLGREGVLPFSNFFASSKPFNSPMVGLFQHFIVCTVTILAPPPGDAYLLVQNLISYPMNIINFAISAGLLWIYWQRRQGKIEWNPPIKAGVFVTGFFTLSNLYLIIAPYVPPSNGESVYSSMPYWIHCVIAWGIFFFGGVYYVVWAQLLPRWGHYKLVSKDVLGEDGFWRVKIAKVYDDTIGDVDTQEDGVIETNIIEHYKSEQEKSL", "function": "High affinity permease for methionine.", "AFDB_id": "AF-P50276-F1-model_v4" }, { "swissprot_id": "P70827", "sequence": "MINKIHGKVIEKKESSLVLMTTVFEFELLVSAFCLANFNLSDKVELFTYLYTRENELKLFGFLNSDEREIFKELIGVSGVGPRAALRVLSNIRYNEFKEAIDKEDIELVSKIKGIGKKMAGKMFLHLQGKLLINSELESTGLFRFKELEESIVSMGFDRKIVNSKIREAFNLAEFANLKDSEKEQFLFKEVLKRISN", "function": "The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.", "AFDB_id": "AF-P70827-F1-model_v4" }, { "swissprot_id": "P42089", "sequence": "MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAIDQKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGIVFVTQESSVTPAGQATTLIDVDKVESVTFFS", "function": "May be involved in maturation of the outermost layer of the spore.", "AFDB_id": "AF-P42089-F1-model_v4" }, { "swissprot_id": "P48417", "sequence": "MASSALNNLVAVNPNTLSPSPKSTPLPNTFSNLRRVSAFRPIKASLFGDSPIKIPGITSQPPPSSDETTLPIRQIPGDYGLPGIGPIQDRLDYFYNQGREEFFKSRLQKYKSTVYRANMPPGPFIASNPRVIVLLDAKSFPVLFDMSKVEKKDLFTGTYMPSTELTGGYRILSYLDPSEPNHTKLKQLLFNLIKNRRDYVIPEFSSSFTDLCEVVEYDLATKGKAAFNDPAEQAAFNFLSRAFFGVKPIDTPLGKDAPSLISKWVLFNLAPILSVGLPKEVEEATLHSVRLPPLLVQNDYHRLYEFFTSAAGSVLDEAEQSGISRDEACHNILFAVCFNSWGGFKILFPSLMKWIGRAGLELHTKLAQEIRSAIQSTGGGKVTMAAMEQMPLMKSVVYETLRIEPPVALQYGKAKKDFILESHEAAYQVKEGEMLFGYQPFATKDPKIFDRPEEFVADRFVGEGVKLMEYVMWSNGPETETPSVANKQCAGKDFVVMAARLFVVELFKRYDSFDIEVGTSSLGASITLTSLKRSTF", "function": "Involved in the biosynthesis of jasmonic acid, a growth regulator that is implicated also as a signaling molecule in plant defense. Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides.", "AFDB_id": "AF-P48417-F1-model_v4" }, { "swissprot_id": "P40960", "sequence": "MERLKQLEEKRRQLKELRERRKQASLFPGSETMGHHPTEVHAKATMVSVSVQTDMEEGSKIQEPQSAYLRRKEVITYDKGIQTDQIEEEQLQENENHTTTDAVAIETTAADENNKDKAENDQPRLELAKPFLVEEAAATLSNASFARLETEVSASGQQAPSNMQQDKDNLMQWNMVSENLQSETDCDCIAQEYDPGKGVLVVVYLRLPPADLQYASSEAAWSVVNVVKCDNASGRNGLLIDMVEFRGTRIMTATILRRYHPESNVISILLATLTGKIILYELRLKQKKPETPVVYVVQRNMVARHYFQHPVVAVIETSSVQDQERVLVAADNGNIMELSCLDLTVLRKPQQLRPVPLSQLLSLENDTCTYTERLQRLAKFDEVGIACMAYTSEDPQYVWIGGEDGGIYKVFWDQPGPLYLSLDNNGFQPAENHSTRVTGLEFHWDDARRLMLLLSCSTDWTVRLWDARAGKAIIGAPLLLGGPVLRARWLEKNNGGENSRTLRCQVWCADGRLVVVNWAFDAKTSLYTATVIS", "function": "Required for viability in the absence of the kinesin-related CIN8 mitotic motor. May be a dynein intermediate chain.", "AFDB_id": "AF-P40960-F1-model_v4" }, { "swissprot_id": "Q9UTN2", "sequence": "MTIRSLNLFIIDKKHQHKSSLSSFQNCKLGIDASFYLTQIIHSFTPQELQSLAVNGESEYLQHRISEFLEQLRTENITPIFVFNGIPLTFEASSQLEVPGKQKSHSALTDFEAFDPYDANIQRNMYRMDASGPANYGESKPTLLYTNQRDHLDRLCDQVKFYLDQCNVEYFVAPYLAMAQLAYFLNGTSSPYIDAIYGSTDLLLFGVKKFITSMNTSSNVKISSDPSSPSTQTTINSAAKSSFTWLDGNALLQDTNGLSWQQFIDSCLLCGTAISPTFPQIEGTFLIKSAMELVRMFGSAYRAVLHFAEIFPQPIFQDYLQQYKRAVCFSKFGIVMDTKGLTLPPVPTESVPNDINIYFGTRLPNEIYFYISRGLIPCKMIGALVSGCFSDPVSILEQHIGDKASQGTFSGANSGLNPGRDNAAAVAAVDQRRFVDDLEEIWSQGLNLLTQPLNRFYQARDIVSLHGHNQQASLKVMHSYDPPLYNDTRAWMIYEENLPSYLSSNFLKEEPVVLFDLLRALNDPVFVKKSFCTEGNIGIKNPPKHPLSSTAEIVLSSCYRFLQIRSFVLTSHQLTSWGCPLLKALENCHLQNQTSVVVLFELLRLRQLKEPSLLSSSSASIADLSITSATEFLAKVATFLPIKQRPEVSKISIVDENLLQFYQLQTSFGSNLKELMAMILASVILNRNVDKSKIDPKLIRKTLPFQNINGSLVSGFVVKRFFEIISKEQEASSQQENIQKAYEIIEKEFPTIGSAENHIAQFLEFWKTFMEGVKEAENTSAIGKLVLSKLFLTNQWIFSLGL", "function": "Involved in post-transcriptional regulation of gene expression by 3'-UTR-mediated RNA regulation. Promotes interactions between mRNA and poly(A)-binding protein. Binds the 3' UTR of mRNAs, centromeric transcripts and antisense-rDNA. Required for the establishment but not the maintenance of heterochromatin at pericentromeres, and for the maintenance of small domains of facultative heterochromatin known as HOODs.", "AFDB_id": "AF-Q9UTN2-F1-model_v4" }, { "swissprot_id": "Q39M29", "sequence": "MPTLLVVEASPRGEQSISRGLTKMFVNQWKREQHDGRVIQRDLMATDLPFVTMPWLGAYFTPPEHQTQDMKNLLRLSDELVAEILSADHIVIGTPVYNYNVPAVLKAYIDHIVRKGKTLGFSGEGLVKGKACTIVMASGGAYTPDSPIRDRDIATGYLRLILKVIGIEDVTVIAGGNAKAVDMGEISRSDFLEAFASDMADAAARPVVQV", "function": "Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.", "AFDB_id": "AF-Q39M29-F1-model_v4" }, { "swissprot_id": "P55603", "sequence": "MAISSNTSRTTRKLLWTLFWCVLAFVYLFPYTWMVLTGFRHGVDTISMPPRFIFEPTLAGFKHLFEVTGFQKYIINSAVVTIVSVVLVIAVSAPAAYALAHVTKRGGTLLVAILVARIIPGIAIGVPVYLLATRLHQLDTYQALIIINVAVNIPFAIWLMRSFFMEVHPTLREAAISDGCSEWQVFTKIMMPLVLGGMLATAVFVFIAVWNEFLFALILTTSVSPTAPLAMLGFRTQYGVQWDAVGAAAFLVSTPVIAFAFIMQRYLVQGLTMGSVK", "function": "Probably part of the binding-protein-dependent transport system y4oPQRS. This system probably transports a sugar-like molecule. Probably responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-P55603-F1-model_v4" }, { "swissprot_id": "Q7VQW0", "sequence": "MYLNATILGQVIAFILFVWFCMKYVWNPLMSVIEERQKKIIDSLESIKTSKMESERIRNEALACLKQAHIKSEEIIKYAYECKMQILHTAQNEAYQERDKILSQTQIQIDQERERIISELRNHVSKLVIESTEKVIDTSINKIIDYDFVDKIIKQLSNYED", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-Q7VQW0-F1-model_v4" }, { "swissprot_id": "G5EFP5", "sequence": "MRVRPASVYRYLLLGVCALLGIYTVYSIIGYDDGSHVPIHRPQRHLYLTVSQDRIGSRFGKLAPKRILYWTTIFGATVPSTALSDCPGLTDRCVIDTNRHQLDSADAVVFHAADISKFPLPVSRKPDQIFVFNSMETPDNSGRFAVPDGFFNWTSTHLYSSDAIHKYGTFLIPTQIAESRGFKVQSYYVQPKRLVKTMKGIFGLISNCHTKSKRELALQELGKHINVTIGGKCASDDRLKSICPAGVECIDVFEQYPFYIAIENTVCNDYVTEKIWSRITVPSIPIVMRRRVYQNILPPKSFIAMDDYKNPSEMANHLRSLEANSTAYGEYFEWRQKGLWTSAPWNAPGYRNGLCRVCELLWKAKDNETEVYKSYDNIWKWFDNESQCETDEFVRSWLSG", "function": "Catalyzes the addition of fucose in alpha 1-3 linkage. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-alpha-1->3-(GlcNAc-beta-1->2-Man-alpha-1->6)-Man-beta-1-4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (GnM3F6) acceptors.", "AFDB_id": "AF-G5EFP5-F1-model_v4" }, { "swissprot_id": "A8XA80", "sequence": "MYHHDSGPHIEEVFDPPSRRTMMQEIETHPDVIAFGKKLRKIKNQPESTFLSSADRMEEIIDAFRDQIAKWEEEEELNEPCEYRQLKIEIFTQKKIEYQRKNNLAVDEFYKKRNLKNHSNRKPLEESRRREEPRDRVHESNIDITHRGDSTSLNHYSRHHYSQRQSQSSRFERERESDEEEENSQPIQRYRSRSPKPSYSYNQSTMQQSQRDDTNVYHRSHQSTSQPPQVRMRSGKSRVTKTHNRKFRPGQKALAEIRKYQKSTDMLIQKAPFVRLVHEIIREQTYKSQDYRIRADALMALQEAAEAFMVEMFEGSVLICNHAKRVTLMPTDIQLYRRLCLRNLS", "function": "Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis.", "AFDB_id": "AF-A8XA80-F1-model_v4" }, { "swissprot_id": "Q9H0F5", "sequence": "MACKISPGANSASLPGHPNKVICERVRLQSLFPLLPSDQNTTVQEDAHFKAFFQSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVHRDSE", "function": "Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.", "AFDB_id": "AF-Q9H0F5-F1-model_v4" }, { "swissprot_id": "Q0CMT2", "sequence": "MPSTYDIYKKLLLLASFLSASQAQQVGTSKAEVHPSLTWQTCTSGGSCTTVNGKVVVDANWRWVHNVDGYNNCYTGNTWDTTLCPDDETCASNCALEGADYSGTYGVTTSGNSLRLNFVTQASQKNIGSRLYLMEDDSTYKMFKLLNQEFTFDVDVSNLPCGLNGAVYFVSMDADGGMAKYPANKAGAKYGTGYCDSQCPRDLKFINGMANVEGWEPSANDANAGTGNHGSCCAEMDIWEANSISTAYTPHPCDTPGQVMCTGDSCGGTYSSDRYGGTCDPDGCDFNSYRQGNKTFYGPGMTVDTKSKITVVTQFLTNDGTASGTLSEIKRFYVQNGKVIPNSESTWSGVSGNSITTAYCNAQKTLFGDTDVFTKHGGMEGMGAALAEGMVLVLSLWDDHNSNMLWLDSNYPTDKPSTTPGVARGSCDISSGDPKDVEANDANAYVVYSNIKVGPIGSTFSGSTGGGSSSSTTATSKTTTTSATKTTTTTTKTTTTTSASSTSTGGAQHWAQCGGIGWTGPTTCVAPYTCQKQNDYYSQCL", "function": "The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.", "AFDB_id": "AF-Q0CMT2-F1-model_v4" }, { "swissprot_id": "Q55EJ3", "sequence": "MVRKKVDTRIRTLIENGVATNHRSFFVIVGDNGKDQVPNLHYILSKSIVKARPSVLWCYKEDLGFSKHKKKKMKLKEKSKSSGIDSVNQEDPFDVFISTTNIRYSYYSESHKILGNTFGMLVLQDFEAITPNLLARTIETVEGGGLIVLLLKTMDSLKQLYTMTMDVHTRFRSENSKGEVVCRFNERFLLSLGKSEQCLVMDDELNILPISSQSRSIEAKQQILETPEQVELREFKQQVKDTDIAGALIENTKTMDQATALLTFIDSISEKTLRSTVTLTAGRGRGKSAALGLAISAAVAFGYSNIFVSSPTPENLNTLFQFVFKGFDSMEYVEHVDYELVKSTNPEFHDAIIRVNIFRSHRQTIQYIQPQDYQKLGQAELVVIDEAAAIPLPLVKNLLGPYLVFMSSTINGYEGTGRSLSLKLIKQLREQSTVVSNSSNKALNSITGRMLREIELNEPIRYSARDPIERWLNELLCLDSTIAKSSPTGCPHPSACQLYYVNRDTLFSYHKASEAFLQKMVGLFVSSHYKNSPNDLLLMSDAPDHHLFVLLGPIDENNTTGLPEILCAVQVSLEGEIAKESILNSIKRGYQASGDLIPWTLTQQYQDEDFPRLSGVRIVRIATHPDYQKMGYGSKALELLTQYYQGEITNLDEVNQEEEEEDEEKVDQNKGSSKISTVKKDNASLLTEVIRPKSNIPPLLFKLSERKPEKLHYMGVSYGLTQQLYQFWSKSKYLPVYLRLTSNDITGEHTCIMLRELNNEQNNTICKDGWLQSFHQDFKKRFINLLGYEFRNFNSSIALNILYEKKVNNTVAVASSTTKNELTQNEMELLFSSYDLKRLESYSNNIVDYHVVIDLLPSLSKLYFTNKLKIEDISLIQSAILLALGLQHKTVDNLIGELNLASNQVLSLFNQTMRKINTELKQKQEKFIQDSMPKLSIVAPRTGQFKSFKGDIKETDMIPLAEDMESELEKGAEEVVNKLKHQLENDSSLSKYLVKGNDEDWSKALKPGSIPNSITIKRKSDENEETDKKENNKKSKTKNNNNNNNNNKKVNNQKSKK", "function": "RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.", "AFDB_id": "AF-Q55EJ3-F1-model_v4" }, { "swissprot_id": "Q9K5Z9", "sequence": "MLVETYDPFQHLAVSAFVAAIPILLLLLCLTVFKMQGIQAALLTLLVTFFIAGLVFHLPFGESIGSIVQGVVQGLWPIGYIIVMAVWLYKIAVASGKFAVLRGSIIGISRDQRIQLLLIGFCFNAFLEGAAGFGVPIAICAVLLVSLGFKPLQAAMLCLIANGASGAFGAIGIPVGIIDTLGLEGQVTSMDVSMMTALTLPMINFTIPFLLIWLMDSWKGIKEILPAILVTSSVYTVSQALITIFIGPELADIIPSLLTMGLLALFLKRWQPRNTFLLNGNGCESEHASLKDVIKAWSPFYLLTMFVFLWSLPAFKGLLAEGGALEFAKWAFVVPGSSIEVGVDFIGATGTAILLAAVTTVTTTKMIRMKESISLLKKVIVDFSIPIMMICAIIGIAKLMTYGGLTMALGEAVATTGAFFPFLSPILGWIGVFMTGSVVNNNTLFAPIQTTAGAIIGTNPSLLVAANTAGGVMAKLVSPQSIAIATAAVGETGNEAALTKMTLKYSFGLLVFVSVWTYILSLLF", "function": "May play a role in L-lactate transport.", "AFDB_id": "AF-Q9K5Z9-F1-model_v4" }, { "swissprot_id": "P33950", "sequence": "MKLKATLTLAAATLVLAACDQSSSANKSTAQTEAKSSSNNTFVYCTAKAPLGFSPALIIEGTSYNASSQQVYNRLVEFKKGSTDIEPALAESWEISDDGLSYTFHLRKGVKFHTTKEFTPTRDFNADDVVFSFQRQLDPNHPYHNVSKGTYPYFKAMKFPELLKSVEKVDDNTIRITLNKTDATFLASLGMDFISIYSAEYADSMLKAGKPETLDSRPVGTGPFVFVDYKTDQAIQYVAHENYWKGRTPLDRLVISIVPDATTRYAKLQAGTCDLILFPNVADLAKMKTDPKVQLLEQKGLNVAYIAFNTEKAPFDNVKVRQALNYAVDKKAIIEAVYQGAGTSAKNPLPPTIWSYNDEIQDYPYDPEKAKQLLAEAGYPNGFETDFWIQPVIRASNPNPKRMAELIMADWAKIGVKTNPVTYEWADYRKRAKEGELTAGIFGWSGDNGDPDNFLSPLLGSSNIGNSNMARFNNSEFDALLNEAIGLTNKEERAKLYKQAQVIVHNQAPWIPVAHSVGFAPLSPRVKGYVQSPFGYDAFYGVSVDGK", "function": "Important role in heme acquisition or metabolism.", "AFDB_id": "AF-P33950-F1-model_v4" }, { "swissprot_id": "P87218", "sequence": "MSKETTSYTNAKLGPLPTKAATIPDNILDAFSLKGKVASVTGSSGGIGWAVAEGYAQAGADVAIWYNSHPADDKAEYLTKTYGVKSKAYKCNVTDFQDVEKVVKQIESDFGTIDIFVANAGVAWTEGPEIDVKGVDKWNKVVDVDLNSVYYCAHVVGPIFRKKGKGSFIFTASMSASIVNVPQLQAAYNAAKAGVKHLSKSLSVEWAPFARVNSVSPGYIATHLSEFADPDVKSKWLQLTPLGREAKPRELVGAYLYLASDAASYTTGADLAVDGGYTVI", "function": "Unknown. The enzyme has no activity toward sorbose.", "AFDB_id": "AF-P87218-F1-model_v4" }, { "swissprot_id": "Q6ID70", "sequence": "MSRNPEVLWAQRSDKVYLTVALPDAKDISVKCEPQGLFSFSALGAQGERFEFSLELYGKIMTEYRKNVGLRNIIFSIQKEERSWWTRLLKSEEKPAPYIKVDWNKWCDEDEEVNSETASDDESAFVNQDSESSDDDGLLYLPDLEKARNK", "function": "Acts as a co-chaperone for HSP90. Controls root development through the modulation of auxin distribution in the root meristem.", "AFDB_id": "AF-Q6ID70-F1-model_v4" }, { "swissprot_id": "P10070", "sequence": "METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHAPLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQMTLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLRKHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASPLGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGPPPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHEAPGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKNNMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDSTQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTISGALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPTGRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAPDHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT", "function": "Acts as a transcriptional repressor.", "AFDB_id": "AF-P10070-F1-model_v4" }, { "swissprot_id": "P52751", "sequence": "MFSLKTVVLALAAAAFVQAIPAPGEGPSVSMAQQKCGAEKVVSCCNSKELKNSKSGAEIPIDVLSGECKNIPINILTINQLIPINNFCSDTVSCCSGEQIGLVNIQCTPILS", "function": "Involved in pathogenicity, may have a role in the elaboration of infective structure.", "AFDB_id": "AF-P52751-F1-model_v4" }, { "swissprot_id": "P25046", "sequence": "MASRVDETTVPSYYYYVDPETTYTYQQPNPLQDLISVYGLDDISRQVARTNLDGTKAVKLRKSYKNQIADLSGKFSTIPTRENGKGGQIAHILFQNNPDMMIQPPQQGQNMSEQQWREQLRNRDIALFQPPNFDWDLCSSVLSQFERSYPSEFANQNQGGAQAPFDIDDLAFDLDGTGKSQSGSNSGNNSKKRKNKSSGSSMATPTHSDSHEDMKRRRLE", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.", "AFDB_id": "AF-P25046-F1-model_v4" }, { "swissprot_id": "O67879", "sequence": "MDIRTHLGINQELSGKPVKVAEGYAEVLLKTQESMKADDKGLVHGGFIFSAADYASMLAVNHPNVVLAGANVKFLKPVKVGDEIICKARVSEDKGKKKKVLVECFKGEDKVFEGEFFTVFLIDMFWRGEKMEVKPFYWKGDKLLLLDQRKLPHQEVWLELKTYEEVAKAIKEMAVRGAPAIGCTAAYGFVLGVKVQKEDPEKVYETLKNTRPTAYNLFWALDRMMKALKEGKDIEEEAKEIEKEDYEANKRMGEIGSEIVPLNAKVLTHCNTGALATAGWGTALGVIRSAHYGGKNIFVWVDETRPYLQGARLTAWELVKESIPHKIITDSTAGFLMKKGMVDLVIVGADRITAKGDVANKIGTYTLAVLCKEHNVPFYVAAPTSTIDSNIKSGEEIIIEERSPEEVKVCGGCAIAPKESDALHLAFDITPAELITGIITEKGIFKPERITEALKD", "function": "Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).", "AFDB_id": "AF-O67879-F1-model_v4" }, { "swissprot_id": "Q50233", "sequence": "MLFRHLVLIISTLMVANTAWSANLPPREKFKRPDSIPAPLSNPLTLEKATLGKTLFFDQRLSRSGGMACATCHSPDQRWSDGRTLPLQAESVSNARRTPTVLNSAWLSALMWDGRATTLEEQAVLPITTAHEMNFDLASLVSRLQRIEGYRPLFTQAFGDDSISQQRITQALASFQRTLVSNIAPFDRWVAGDEQAISESAKRGFAVFNDKNKANCVACHSSWRFTDDSFHDIGLPSKDLGRGAKVPSQVTLMQHAFKTPSLRDLSIDGPYMHDGSIRGLKTVIKHYKSEAIQRESLSKDMQKFELSNLEESDLIAFIQSLDGGALKIQAPMMPE", "function": "Involved in methylamine metabolism. Essential for the maturation of the beta subunit of MADH, presumably via a step in the biosynthesis of tryptophan tryptophylquinone (TTQ), the cofactor of MADH.", "AFDB_id": "AF-Q50233-F1-model_v4" }, { "swissprot_id": "Q72HP1", "sequence": "METLLLVQLFHELALKGKNRPFFLKRAKAHVRRALKGLGVALEGEWPMALLFRLPEEAWPEAKARLQDTLGVERFARVHRTPPDLEALKAALEKALEGQAFGSFRITAKRSDKAFPLTSPEIERALGAFVKGKTGAPVRLKGAEREFVVRVLPGAALLEVERHPGPGGLPPGVSGRVVALLSGGIDSPVAAYRLMRRGAEVVLVHFHPFPLLSGASREKAKALAERLARFQHRLRLHLVPFSEVQRHIIVEAPTAYRVVLYRRYMLRIAEAIAREEGALALCTGDSLGQVASQTLENLHAVNQAATLPVFRPLIGWDKEEIVAEAQRIGTYATSILPDEECCTLFAPKHPVTRARLEVVLETEARLPTEELLALALKEREVLTYTWPGKPLPEEPEGAFIMEHGPA", "function": "Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.", "AFDB_id": "AF-Q72HP1-F1-model_v4" }, { "swissprot_id": "A8YXN4", "sequence": "MMGLRKMCRGSLMSKIIIGRYIPGDSLVYKMDPRGKLLITILFIWAIFLANNPITYAIITFFCFLAIIATGLKARVFWNGVKPLIGLIFFTSLLQLFFMTGGHVFWHWWIFSISSYGVENAIYIFIRFTLIILISTVMTVTTMPLEIADAMEWLLKPLKIFKVPVDEIALVISIALRFVPTLFDETLKIMNAQRSRGADFNDGGLIKRAKAIAPILVPLFIHSLETAIDLSTAMESRGYRGSAGRTKYRVLNWSKYDLISLAYFILLVGLLLIFRTH", "function": "Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.", "AFDB_id": "AF-A8YXN4-F1-model_v4" }, { "swissprot_id": "Q9QZ85", "sequence": "MGQLFSSPKSDENNDLPSSFTGYFKKFNTGRKIISQEILNLIELRMRKGNIQLTNSAISDALKEIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVEVTMERHPYKHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRFKKNDIDIAKAISMMKKEFYFVRTKVDSDITNEADGKPQTFDKEKVLQDIRLNCVNTFRENGIAEPPIFLLSNKNVCHYDFPVLMDKLISDLPIYKRHNFMVSLPNITDSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVFGVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDEETIQERLSRYIQEFCLANGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICLRN", "function": "GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.", "AFDB_id": "AF-Q9QZ85-F1-model_v4" }, { "swissprot_id": "A0A172M421", "sequence": "MRVLNFVLTTTVVLLTSSEGIASSPQVRHIKPNVAIDHLSIRSLRATENPGSDESRLNEKDTGFDPDGSSSKEDEDIGEPTFWEKVRFRYWKTMGKTPGDLRKEYFEGMDEAVIKNNPNYKLVQQYEVYYDEKSSE", "function": "Effector that acts as a broad suppressor of cell death to interrupt plant immunity. Inhibits cell death induced by cell death-inducing proteins, including the PAMP elicitor INF1 from P.infestans.", "AFDB_id": "AF-A0A172M421-F1-model_v4" }, { "swissprot_id": "I3R9M8", "sequence": "MSTDSDAETVDLADGVDHQVAMVMDLNKCIGCQTCTVACKSLWTEGGGRDYMYWNNVETKPGKGYPRNWEESGGGWKSSEHKERKPGQIPDKEDYGDAWEFNHEEIMYNGSDRPLRPDSDPEWGPNWDEDQGTGEYPNSYYFYLPRICNHCTHPSCVEACPRKAIYKREEDGIVLIDQERCRGYRYCVEGCPYKKVYYNATQKTSEKCIFCYPRIEGEGPDGKTFAPACAEDCPPQLRLVGFLDDEQGPIHKLVEEYEVALPLHPEYQTQPNVYYIPPFAPPQHSEDGESVDVDRIPRNYLEELFGERVHDALDTIEREREKVNRGGGSELLDMLTDTNPARKFRLEVFDDD", "function": "The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers.", "AFDB_id": "AF-I3R9M8-F1-model_v4" }, { "swissprot_id": "O42971", "sequence": "MAQIRQEALKKQKSETQKSTEGFVDIGNLAQWTCSSEKSGFPIRLVRDDNIDTYWQSDGSQPHTIHIKFVKRVSIKYVSMYLQYTLDESYTPSTLRISAGTGFQDLEIVTTVQVEEPTGWVHVPVGDFGRNGLLDVHLIQIKILANHQSGKDSHVRLIKIYAPEIEQPAIAVDEIPYTSLQFISRNQLR", "function": "Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Acts as a positive regulator of the anaphase promoting complex (APC)-cyclosome. Involved in G1 cell cycle arrest in response to nitrogen starvation. Required for ubiquitination and degradation of the mitotic B-type cyclin, cdc13.", "AFDB_id": "AF-O42971-F1-model_v4" }, { "swissprot_id": "Q9CAD0", "sequence": "MATGENRTVPDNLKKQLAVSVRNIQWSYGIFWSVSASQPGVLEWGDGYYNGDIKTRKTIQAAEVKIDQLGLERSEQLRELYESLSLAESSASGSSQVTRRASAAALSPEDLTDTEWYYLVCMSFVFNIGEGIPGGALSNGEPIWLCNAETADSKVFTRSLLAKSASLQTVVCFPFLGGVLEIGTTEHIKEDMNVIQSVKTLFLEAPPYTTISTRSDYQEIFDPLSDDKYTPVFITEAFPTTSTSGFEQEPEDHDSFINDGGASQVQSWQFVGEEISNCIHQSLNSSDCVSQTFVGTTGRLACDPRKSRIQRLGQIQEQSNHVNMDDDVHYQGVISTIFKTTHQLILGPQFQNFDKRSSFTRWKRSSSVKTLGEKSQKMIKKILFEVPLMNKKEELLPDTPEETGNHALSEKKRREKLNERFMTLRSIIPSISKIDKVSILDDTIEYLQDLQKRVQELESCRESADTETRITMMKRKKPDDEEERASANCMNSKRKGSDVNVGEDEPADIGYAGLTDNLRISSLGNEVVIELRCAWREGILLEIMDVISDLNLDSHSVQSSTGDGLLCLTVNCKHKGTKIATTGMIQEALQRVAWIC", "function": "Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involved in seed mucilage production. Activates the transcription of GL2.", "AFDB_id": "AF-Q9CAD0-F1-model_v4" }, { "swissprot_id": "P19775", "sequence": "MTQVHFTLKSEEIQSIIEYSVKDDVSKNILTTVFNQLMENQRTEYIQAKEYERTENRQSQRNGYYERSFTTRVGTLELKVPRTRDGHFSPTVFERYQRNEKALMASMLEMYVSGVSTRKVSKIVEELCGKSVSKSFVSSLTEQLEPMVNEWQNRLLSEKNYPYLMTDVLYIKVREENRVLSKSCHIAIGITKDGDREIIGFMIQSGESEETWTTFFEYLKERGLQGTELVISDAHKGLVSAIRKSFTNVSWQRCQVHFLRNIFTTIPKKNSKSFREAVKGIFKFTDINLAREAKNRLIHDYIDQPKYSKACASLDDGFEDAFQYTVQGNSHNRLKSTNLIERLNQEVRRREKIIRIFPNQTSANRLIGAVLMDLHDEWIYSSRKYINFDK", "function": "Required for the transposition of the insertion element.", "AFDB_id": "AF-P19775-F1-model_v4" }, { "swissprot_id": "Q06SH7", "sequence": "MIDLIKYPVINFKSYRALVLNNQYMFNVDLRLTKPQIKKLIEQYFEVNVISVNTHRPPRKKRLYIQTSPGYKKRYKRVIITLQKDQEIPYIKSLMASNLAAAMQRVQNAQTSPNSNEA", "function": "Binds to 23S rRNA.", "AFDB_id": "AF-Q06SH7-F1-model_v4" }, { "swissprot_id": "Q9ULD9", "sequence": "MSVNISTAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSLTPQILPSYFSPSSSNIAAPVEQLLVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCESPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRRTPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEEGLSNVALECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKAKQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDREKKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPVNWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLSPGFHYPVYGKMSGREETEKVNTSPSVNTKTTTESKALDLLQQHANQYRSKSPAPVEKATAEREREAERERDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQASASGMFPGQRRE", "function": "Transcription factor, which represses ZNF609 transcription.", "AFDB_id": "AF-Q9ULD9-F1-model_v4" }, { "swissprot_id": "Q2KHN1", "sequence": "MGGGYDLNLFASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCILRWLARQKTCPCCRKEVKRKKVVHMNKLRKTIGRLEVKCKNADAGCIVTCPLAHRKGHQDSCPFELTACPNEGCTSQVPRGTLAEHRQHCQQGSQQRCPLGCGATLDPAERARHNCYRELHNAWSVRQERRRPLLLSLLRRVRWLDQATSVVRRELAELSNFLEEDTALLEGAPQEEAEAAPEGNVGAEVVGEPRANIPCK", "function": "May be involved in acrosome formation of spermatids.", "AFDB_id": "AF-Q2KHN1-F1-model_v4" }, { "swissprot_id": "P63406", "sequence": "MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDVPTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGLPRD", "function": "Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate.", "AFDB_id": "AF-P63406-F1-model_v4" }, { "swissprot_id": "Q9NXL2", "sequence": "MEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQEKMTPQGECSVAETLTPEEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLKKIYMQEGKPNLLDMGSLMIKPIQRVMKYPLLLCELRNSTPPSHPDYRALDDAFAAVKDINVNINELKRRKDLVLKYKKNDEDESLKDKLSKLNIHSISKKSKRVTNHLKILTRGESQVKDNTFNREEKLFRALEKTVRLCVKNISLCLQHIQDAMPLALQSVMDLQEISYNKDDEMDYSETLSNALNSCHDFASHLQRLILTPLSALLSLFPGPHKLIQKRYDKLLDCNSYLQRSTGEESDLAKKEYEALNAQLVEELQAFNQAARKILLNCLCSFITLLRDLMLVAQQAYSTLVPMPLLVSSISEIQNQVLEEIQNLNCVKENSATFIERKLSFEKKKPVQILPEMPHQTDIHRSKLLSTYSAEELYQAKRKCNATQEYDINLLEGDLVAVIEQKDPLGSTSRWLVDTGNVKGYVYSSFLKPYNPAKMQKVDAENRFCDDDFENISLFVSSRPASDSVTGTSESSIGDSSSSLSGTCGKFETNGTDVDSFQEVDEQIFYAVHAFQARSDHELSLQEYQRVHILRFCDLSGNKEWWLAEAQGQKGYVPANYLGKMTYA", "function": "May act as a guanine-nucleotide releasing factor.", "AFDB_id": "AF-Q9NXL2-F1-model_v4" }, { "swissprot_id": "Q9SSE9", "sequence": "MDSVEEEGVVRVEEENGRGGLRRHRRVSTKLANYVDPPTDDEEDGGPKRKGKRGGNRAPKKTPKKDEEMQKNEIDEANRVTGLVKEKRAATKILNRKDSIIEVGEASGSMPKEVKGIRIGKRKGEIDGEIPTKPGKKPKTTVDPRIIGYRPDNMCHQCQKSDRIVERCQTCNSKRYCHPCLDTWYPLIAKEDVAKKCMFCSSTCNCRACLRLDTKLKGINSNLIVSEEEKVQASKFILQSLLPHLKGINDEQVAEKEVEAKIYGLKFEEVRPQDAKAFPDERLYCDICKTSIYDLHRNCKSCSFDICLSCCLEIRNGKALACKEDVSWNYINRGLEYEHGQEGKVIEKPANKLDDKLKDKLDGKPDDKPKGKPKGRPKGKPDDKPKGKLKGKQDDKPDDKPDEKPVNTDHMKYPSLWKANEAGIITCCCGAGELVLKRLLPDGWISELVNRVEKTAEAGELLNLPETVLERCPCSNSDRHIDIDSCNLLKAACREGSEDNYLYSPSVWDVQQDDLKHFQHHWVKGEPVIVRNVLEATSGLSWEPMVMHRACRQISHVQHGSLKDVVAVDCLDFCEVKVNLHEFFTGYTDGRYDRMGWPLVLKLKDWPPAKVFKDNLPRHAEEFLCSLPLKHYTHPVNGPLNLAVKLPQNCLKPDMGPKTYVASGFAQELGRGDSVTKLHCDMSDAVNILTHISEVPNMQPGIGNLKKKHAEQDLKELYSSVANKEEMMEILENSRQQVQNVETDDGALWDIFRREDIPKLESYIEKHHKEFRHLYCCPVSQVVHPIHDQNFYLTRYHIMKLKEEYGIEPWTFNQKLGDAVLIPVGCPHQVRNLKSCNKVALDFVSPENVSECLRLTKQYRLLPPNHFAKEDKLGVKKMIVHAVDKALRDLSGEKSPEPEEKKQNMRGPKKGAAKAVAKALKDLSPSEKKSSEAAEEEISNGIVNAIDKGLKDLPPSEEKSSEAKVEISNGIVSAMDKDLEHISSSEKKSTEEEGVKRPNIVRTYERRKKLGSEVTNAYIDRLEMEKM", "function": "Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me2 and H3K9me1. No activity on H3K9me3, H3K4me3/2/1, H3K27me3/2/1 and H3K36me3/2/1. Counteracts the DNA methylation of endogenous genes. Involved in the control of several developmental processes by protecting genes from silencing. Demethylates H3K9me2 in the promoter regions of RDR2 and DCL3 and mediates the repression of ectopic non-CpG methylation at RDR2, DCL3 and APC13 loci. Protects also a large number of transcribed genes from non-CpG methylation. May regulate gene expression via a pathway involving indirect silencing of gene expression through small RNA-directed DNA methylation (RdDM)-directed repression. Modulates stomatal development by regulating the methylation-mediated silencing of ERECTA receptor genes (e.g. ER, ERL1 and ERL2) and preventing cell divisions.", "AFDB_id": "AF-Q9SSE9-F1-model_v4" }, { "swissprot_id": "Q8H0W3", "sequence": "MVSRNSDGYFLDPTGMTVPGLGPSFTAAVSSSSSPTTSSTAVAVADVTAMVSSSEEDLSKKIRKPYTITKSRESWTEPEHDKFLEALQLFDRDWKKIEAFIGSKTVIQIRSHAQKYFLKVQKSGTGEHLPPPRPKRKAAHPYPQKAHKNVQLQVPGSFKSTSEPNDPSFMFRPESSSMLMTSPTTAAAAPWTNNAQTISFTPLPKAGAGANNNCSSSSENTPRPRSNRDARDHGNVGHSLRVLPDFAQVYGFIGSVFDPYASNHLQKLKKMDPIDVETVLLLMRNLSINLSSPDFEDHRRLLSSYDIGSETATDHGGVNKTLNKDPPEIST", "function": "Probable transcription factor.", "AFDB_id": "AF-Q8H0W3-F1-model_v4" }, { "swissprot_id": "P0AAV5", "sequence": "MQRARCYLIGETAVVLELEPPVTLASQKRIWRLAQRLVDMPNVVEAIPGMNNITVILRNPESLALDAIERLQRWWEESEALEPESRFIEIPVVYGGAGGPDLAVVAAHCGLSEKQVVELHSSVEYVVWFLGFQPGFPYLGSLPEQLHTPRRAEPRLLVPAGSVGIGGPQTGVYPLATPGGWQLIGHTSLSLFDPARDEPILLRPGDSVRFVPQKEGVC", "function": "Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.", "AFDB_id": "AF-P0AAV5-F1-model_v4" }, { "swissprot_id": "O76554", "sequence": "MLIIIQSLLLATTASLCIADTPVPTQIRLVHDLLDNYDKKAKPMWDNSKPINVSFSMDLYQILELNEPQQYILLNAWIIERWFDEFLYWNPDDYENITELRLPYDSIWLPDTTLYNSLVMKDDDTRRLLNSKLTTDTHRRAALIELLYPTIYKFSCLLDLRFFPFDVQVCTMTFSSWTYDQKGIDYFPYSDKIGTSNYLENEGWYILQTKIKRQEVKYACCPNNYTLLQLTLYLRRKPLFYLVNLIIPTSIITLIAIVGFFTTSSASGMREEKVSLGITTLLSMSILMLMVSDQMPTTSTFIPLIGWFILAMIIVISLGTVVSSVIIAIQKRGSLGERMSKRALKFAKVLAWFTCTSLPPHVEKEHMMEAFDAPTPLVEVRPLQLASVKESVRNKWVSGARRATQRGNSGLALISDKSTDPLIHLSPTAHQPDESISPSAPPVPSSSPLPPPLTPGPADDVVSVASELSSKFLTSRMRPKSQKDNTFAAMQSSIKANRQLAVAEFEWFATVVERTCFVIFVVAFLIITFGINFIGFIHWHQAGVEYGG", "function": "Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.", "AFDB_id": "AF-O76554-F1-model_v4" }, { "swissprot_id": "K2RLM2", "sequence": "MLQLILHHPYASLAAGILLYFFCLATYRLYLSPVAGFPGPRLAALTRFYEYYYDGVKGGQFVWKVKDLHQKYGRLSCSTVVGQELKLEQGPIVRIGPCELHVNDPTFVSTLYPATGQRRNKDPFWTDQFGPKTAFGTVDHDHHRLRRGPFNRFFSKANVTRLEPMLRQQANKLCEKLEKYAGTGRVIDLSDPFGCMATDIISTYALGYSFNFLDAEDFQPNLLQGLNGFTPLAPTVKQFPWLLKLLRALPDSWALKINPKIAPFLDFQRTMKKVITDVEAEVQSEAGRPKADQATTIFHEVLRGDIPPEEKETARLWQEGEAIIGAGTFLQTPQEAV", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones. The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpmpA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpmpD through the action of the prenyltransferase dpmpC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpmpE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpmpB (Probable). The short chain dehydrogenase/reductase dpmpG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpmpH reduces the ketone to the 8R hydroxy group to yield higginsianin B. Higginsianin B is further methylated by the methyltransferase dpmpI to produce the intermediate named FDDP B. The cytochrome P450 monooxygenase dpmpJ then oxidizes the C-26 methyl to primary alcohol, producing the final diterpenoid pyrone with a C-26 primary alcohol on the gamma-pyrone moiety named FDDP C.", "AFDB_id": "AF-K2RLM2-F1-model_v4" }, { "swissprot_id": "Q9NAA7", "sequence": "MATDALYNEVAEIIRCVLAKEKSVRNAVYGSSYKNKKALLRLSCESLKFRPVFDEILQDKELKSMKRDANIGGSVELLYVLMYETLVGSGLTRCSQELKSVISRRIQRIKEVEHAMQDEGRGIKAMKEADDGMKKIQIPRYARINTLKWTADEAMKTLETEKWKILGTLKPENFAEMVTKMKDDEVYVDPHVENLIIFAPNIQNFYEYWMVEQRYLILQDKASCLPAFLLNPRPGSQVFDTCAAPGMKTSHAAAIMENQGKVWAMDRAADRVATMKQLLDASKVAIASSFCGDFLKTDVTDKKFSKVKFAIVDPPCSGSGIVKRMDEITGGNAEKERLEKLKNLQAMILKHALKLPGLKRAVYSTCSVHEEENEQVVDEVLLDTYVRQNYVLKKNVLPEWTYRGLKTYEVGEHCLRANPKVTLTNGFFVAVFERVKSSE", "function": "S-adenosyl-L-methionine-dependent methyltransferase which methylates the carbon-5 position of cytosine 2381 to 5-methylcytosine (m5C2381) in 26S rRNA. Plays a role in the production of mature 5S, 5.8S, 18S and 26S rRNAs and promotes the processing of the internally transcribed spacer 2 (ITS2), which separates the 5.8S and 26S rRNAs on large pre-rRNA precursors. May play a role in the translation of leucine and proline codons (Probable). May play a role in maintaining ribosomal frameshifting in response to osmotic stress. Not required for global translation.", "AFDB_id": "AF-Q9NAA7-F1-model_v4" }, { "swissprot_id": "O49663", "sequence": "MGSEQNDSTSFTQSQASEPKLCVKGCGFFGSPSNMDLCSKCYRGICAEEAQTAVAKAAVEKSFKPSPPRSLFIAEPPAVVVEPKPEKAAVVVVSAEPSSSAVPEANEPSRPARTNRCLCCNKKVGIMGFKCKCGSTFCGEHRYPETHDCSFDFKEVGRGEIAKANPVVKADKIQRF", "function": "May be involved in environmental stress response.", "AFDB_id": "AF-O49663-F1-model_v4" }, { "swissprot_id": "Q4P2W6", "sequence": "MATSSSDRWPIPLKQHIPTLIFITVTVLTSNLVSRTQPTAYLDEIFHIPQAQQFCSALSSTSLFSAQQVWRQLTSVRYDAQLTTPPGMYAISVGMAKVLPGWECKDVVWLRSTNLVLLLTLPVLVARILGQIEEQARIASAAEDYSPSKTITQNLGKEITRHEIEMLQAKAKLQLPPTPSASHDDLAHIEPPTISIAQAALPAPTGSAAPLLRALKQREASAYTMALACTICFLPPLWFFGFLYYTDLASTWLVLAMLSLYNDLNTSNAHVAPTITGLLIALTSILAVAVRQTNIVWIGFAAAQATLSRVGKHVSHTQQGSDPVTQAIGMVKGAFGDNKKGWWTAVAINAAPMVPVLAVCVLFLRWNGSIVLGEKAAHQVALHLPQMGYFVAFALGFGLFPLLFSLQSMSHKAQDQGPSSSTLATFTHSVRSAVSALIDSTIASPGCILALAAALAGFYIAVDRFTIEHAYMLADNRHYTFYIWRKYRSSYAIPALDGMTIEPKLAVVPLFALALIAWSRALTHHAVNKRTGALFSLLFWMATAAVLVPTPLIEPRYFLMAYLLLRIYSHPYAPCEKQEKSAQLKWIYLALEAATYAAVNVITVGLFVNRPFQWPSHAVDVSRNEHTTMRFLW", "function": "Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.", "AFDB_id": "AF-Q4P2W6-F1-model_v4" }, { "swissprot_id": "P95727", "sequence": "MNSPHQQQTADRRQVSLITGASRGIGRTLALTLARRGGTVVVNYKKNADLAQKTVAEVEEAGGQGFAVQADVETTEGVTALFDEVAQRCGRLDHFVSNAAASAFKNIVDLGPHHLDRSYAMNLRPFVLGAQQAVKLMDNGGRIVALSSYGSVRAYPTYAMLGGMKAAIESWVRYMAVEFAPYGINVNAVNGGLIDSDSLEFFYNVEGMPPMQGVLDRIPARRPGTVQEMADTIAFLLGDGAGYITGQTLVVDGGLSIVAPPFFADAGEALELPPRPTRDA", "function": "Involved in the biosynthesis of the antifungal antibiotic ansatrienin A (mycotrienin I). Catalyzes three of the reductive steps involved in the formation of the cyclohexanecarboxylic acid (CHC) moiety of ansatrienin from shikimic acid. Can use 3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA, 5-hydroxycyclohex-1-ene-1-carbonyl-CoA and cyclohex-1-ene-1-carbonyl-CoA as substrates.", "AFDB_id": "AF-P95727-F1-model_v4" }, { "swissprot_id": "C8WV58", "sequence": "MAKHAPIFPNVQGFLHGGDYNPDQWLAYPDVLEQDVQLMREAKWNVVSLGIFSWVSLEPEEGLFTFEWLDEAIERLTHAGVRILLATPSGARPAWLSAKYPEVLRVGPDGRRNRHGGRHNHCYTSPIYREKVRIINRKLAERYAHHPGVIGWHVSNEYGGECHCPLCQEAFREWLKRKYKTLDALNHAWWTPFWSHTYTDWSQIESPMPHGETSIHGLNLDWKRFVTDQTVDFCRHEIEPLKQVNPNLPVTTNFMGTYPGLNYWRFRDVLDVISWDSYPRWHAHETLVPEAVHTAMVHDLNRSILKKPFLLMESTPSVTNWQAVSKQKRPGVHVLVSLQAVAHGADSVQYFQWRKSRGSYEKFHGAVVDHVGHANTRVFRDVQAVGEMLERLAPMAGAEVKADAAVIFDWENRWALEDAKGPRNIGMHYEETVVNHYAALWRMGVPMDVIDEEQPLDGYKLVVAPMLYMVRPGVAERMKAFVERGGSLVLTYWSGIVDENDLVFLGGFPGPLRELAGVWAEEIDALYDGERVPVRVADGNPLGLAGHYEARELCEVVHLEGAEPIAVYGADYYEGMPAATVHRVGKGKVYYVAARLEDAFLRDFFARVAAEAGVARAIERELPDGVSAMVRSGDGVEYVMLMNFTPEAREVALDEAEYKPLYGEAPTDGAVRLPAYGVSVLERPARNG", "function": "Hydrolyzes o-nitrophenyl-beta-D-galactopyranoside (ONPG) and p-nitrophenyl-beta-D-fucopyranoside (PNPF), but not p-nitrophenyl-beta-D-glucopyranoside (PNPG), p-nitrophenyl-beta-D-xylopyranoside (PNPX) or p-nitrophenyl-beta-D-arabinopyranoside (PNPA). Also hydrolyzes lactose, including lactose in milk.", "AFDB_id": "AF-C8WV58-F1-model_v4" }, { "swissprot_id": "A4YEP4", "sequence": "MQNSPWFKENPLRLFITGRPGVGKTTLIKGLVSELRELKIAGFYTEEVRERGERTGFLFVVIGDGSCPLASTKPIGKERVGRYFVVDSLTLLPQVKQRLEVADLVIMDEIGPMEKKIGDLWKLIQGVLSSNKPVVASVHRSMNIEGKRYELTPVNRDRVREDILNEIRRYFGTKQDTFSL", "function": "Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.", "AFDB_id": "AF-A4YEP4-F1-model_v4" }, { "swissprot_id": "Q7TP98", "sequence": "MVSTHLTSTTLPDCYRSLIVNSELGSSALMDLNSPSFLYPLLHTPADKGTLCTYQAALGKVYASLEVIGVGDDKLQAVHGLNGGKPHRDILGSRITRPTGIKPLCLPRHILAYDWLAQSLLGIVIGSISLAYNELLMMEKLKGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTFLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE", "function": "Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay. Plays also a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71.", "AFDB_id": "AF-Q7TP98-F1-model_v4" }, { "swissprot_id": "Q588Z2", "sequence": "MFKPVVKSRSSRSFCYLAGCLAMVAATLSSTAQAKSEWACPEGFTPKAGLNTDFPSDGKKRAFVVVPPKDSAGGAPVWVPMVGTVEATNWNLNVPRSGNNAKLAEHGYMVISPVRQCAEQDPNLGAGACNGVGKDGWTWNPWNDGRAPDASGDKYKTDAGDDVRFLEAMVRCVGTKWKLDRKRLFLGGISAGGTMTNRALLFDSEFWAGGMPISGEWYSTKDDGSTVPFQETRKMVAAAPAKIWQGRVGPYPLPSKLDPMVVITVWGGEKDLWDCGPPLGLCSDYRPTTQASSNYFSSISNVVHVACSATHGHMWPQVNTDAFNLWALNTMASHPKGSSPKDFKLTAPPEGYSCKIGRFTDHYK", "function": "Catalyzes the hydrolysis of 4,6-nonanedione, a beta-diketone compound. Also mediates hydrolysis of oxidized polyvinyl alcohol (PVA) in the second step in the degradation of polyvinyl alcohol. Not active toward the monoketone structure.", "AFDB_id": "AF-Q588Z2-F1-model_v4" }, { "swissprot_id": "P25356", "sequence": "MNSIINAASKVLRLQDDVKKATIILGDILILQPINHEVEPDVENLVQHELTKIIQGYPIQDNMIINSKKGTVEDDLCELNNYTCFALSKSFDLCHDSRNFNIAQPKRWIQLLETLTDSVSFAVIVQIILTLSNISLINKQTLGKLKKLRIRIFEILSNKNDSWKSTLLQKNLIEWYIFMLSVDCTPLELQNLYLHKELKFCNGILNSLTLQVSDPRSQNYLQFENTYKLFQIQKSSRINNSFLFYIEFNSVTSNRIMTIERHIYLEIKEGQFCISNDNYIIGLFENFEFEAGTLYFIGVLIDHNNRITLYVDGSMINQLTLFENSICQLSTCELGSMICSIKVYRFYLWDGLLTEFAINILQAIGTNYQYTFSKKKEGPEVLSLCQDFLIAKAHLMARPTTEISSTKYIDEIELLEMENIIIDVNPNDILQDFTESSNFTVKFEESTNSKNIPEVGKCYFYRSSNLVSKFVSIDSIRLAFLNMTESGSIDDLFHHVSHLMNLLRNIDILNWFKKDFGFPLFAYTLKQKITQDLSQPLNIQFFNLFLEFCGWDFNDISKSIILDTDAYENIVLNLDLWYMNEDQSSLASGGLEIIRFLFFQISSLMEASIYSKFNSNKFNDMNILEKLCLSYQAVTKRENQNSKFNELSSDLISVFVTLLKSNTDKRHLQWFLHLSYYFIKRKDVRSTEIILQAVDQLFSFYLDQGSDENAKILSEIIPLKLILMIMDQIVENNESNPITCLNILFKVVLTNKPLFKQFYKNDGLKLILTMLCKVGKSYREEIISLLLTYSIGNYTTANEIFSGAEDMIGGISNDKITAKEIIYLAVNFIEWHVINSNASDSSSVLDLNNHILRFVEDLKSLSAVPINESVFDPKKSYVMVSLLDLSIALNESEDISKFKSSSKVISELIKGNIMCALTKYAAYDFEVYMSTFFCHSTEYKLVYPKTVMNNSSYLELSFIVTLLPEILNDLVDSNNNLNLMMLKHPYTMSNLLYFLRKFRPDTSQIVMPKDFYFSSYTCLLHCVIQIDKSSFYHFKNVSKSQLLQDFKICIMNLIYSNTLKQIIWEKEEYEMFSESLMAHQEVLFAHGACDNETVGLLLIFFANRLRDCGYNKAVFNCMKVIIKNKERKLKEVACFFDPANKSEVLEGLSNILSCNNSETMNLITEQYPFFFNNTQQVRFINIVTNILFKNNNFSPISVRQIKNQVYEWKNARSEYVTQNNKKCLILFRKDNTSLDFKIKKSISRYTYNLKTDREENAVFYRNNLNLLIFHLKHTLEIQSNPNSSCKWSSDFAEDFDGMKRRLLPAWEPKYEPLINEEDANQDTITGGNRQRRESGSILSYEFIEHMETLESEPVGDLNENRKILRLLKDNDSIATIWNCSLIIGLEIKEGILIHGSNYLYFVSDYYFSLEDKKILKLSEVSQESRDMTVSLINGPDVKRVSTFLKHEVFVWKLLDITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDVLRVLNKIPKHLPADPIFSSVLQEINDRGNSIVARNGIGKASIASKFTSVFSANNSLIDGFEISKKWVRGEISNFYYLLSINILAGRSFNDLTQYPVFPWVIADYESNVLDLENPKTYRDLSKPMGAQSEKRKLQFIERYEALASLENADSAPFHYGTHYSSAMIVSSYLIRLKPFVESFLLLQGGSFGPADRLFSSLERAWSSASSENTTDVRELTPEFFFLPEFLINVNSYDFGTDQSGKKVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEWIDLIFGYKQKGDIAVKSVNVFNRLSYPGAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPEKIACNVQQLTTEVWRKVPMKPIFEKTIFNLNEKNRSVDYVIHDPSYFDSLYWRGFAFPNLFFRTEESLVSLRIVHKNWLKIGLDIFKKTHMAQITSFAYWKLGEFITGDKNGLIKVWKYRKDKHSVSGNLENKKTMFGHLCELKEMRCYHDYNTLLTLDISGLVYVWDMINFELVRQITNDAQKVAISQHAGSIMVLTKNNAISIFNLNGQIYTSKKFEPAKIVSSIDFFDFTKLDAGYRKHIYWKEMEILLVGFEDGTIEIYELFLNFHNEWAIKLLKQLCTEKGKAITSIKGQGKTYLSQKRRKDTAEPHEIEVIAGTLDGRLAIWY", "function": "May be involved in protein sorting and cell wall formation.", "AFDB_id": "AF-P25356-F1-model_v4" }, { "swissprot_id": "A0R666", "sequence": "MTTASQTRTPRGRRSARPSGDDREAAILATAQRLLETKKFAEISVDDLAKGAGISRPTFYFYFPSKEAVLLSLIDPLIKRADSGFDNAVESMPADPQRAIRRGIEIFFNSFGSHPATARAGTEALKSSPEFKEFWSGLMQKWIAATAALITAERERGAAPDTIPALDLATSLNLMNERTMMAALADEQPGVAPEKVVATLTHIWLNSIYGTLPVGTA", "function": "Involved in the repression of teh monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).", "AFDB_id": "AF-A0R666-F1-model_v4" }, { "swissprot_id": "Q8LDI5", "sequence": "MARVVKIDSAESWNFYVSQAKNQNCPIVAHFTALWCIPSVFMNSFFEELAFNYKDALFLIVDVDEVKEVASQLEVKAMPTFLFLKDGNAMDKLVGANPDEIKKRVDGFVQSSRVVHIA", "function": "Possesses low disulfide reductase activity, but efficient protein disulfide isomerase activity. Does not possess deglutathionylation activity.", "AFDB_id": "AF-Q8LDI5-F1-model_v4" }, { "swissprot_id": "A6UVH2", "sequence": "MLKTLPPTIREKKRYISFKIIYNNELSGGEVVNLIRSSLINYYGVWGSSKCNPWLIDYTHPKGLLRITREEVDFVKSALISINEYKKNPINIIILGVSGTIKKSREKFLKVPHEKYYKVIQRRKKENSYKNRLRK", "function": "Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.", "AFDB_id": "AF-A6UVH2-F1-model_v4" }, { "swissprot_id": "P55721", "sequence": "MTGSSIVSLMSQSLVVFMIWILPPLIASVIVGLTIGIIQAATQIQDESLPLTVKLLVVVAVIGLFAPVLSAPLIELADQIFTEFPAMTLGY", "function": "Could be involved in the secretion of an unknown factor.", "AFDB_id": "AF-P55721-F1-model_v4" }, { "swissprot_id": "P79273", "sequence": "MAAALLARACGPVRGALWPRDCRRLHTIFQSVELPETYQMLRQTCRDFAEKELVPIAAQVDKEHRFPEAQVKKMGELGLMAMDVPEELSGAGLDYLAYTIAMEEISRGCASTGVIMSVNNFLYLGPILKFGSKEQKQQWITPFTSGDKVGCFALSEPGNGSDAGAAATTAQADHDSWVLSGTKAWITNAWEASAAVVFASTDRSLQNKGISAFLVPMPTAGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMKTLDMGRIGIASKALGISQAALDCAVNYAENRRAFGVPLTKLQGIQFKLADMALALESARLLTWRAAMLKDNKKNPFIKEPAMAKLAASEAATAITHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLKSYRS", "function": "Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.", "AFDB_id": "AF-P79273-F1-model_v4" }, { "swissprot_id": "P25265", "sequence": "MVGAVIDLFCGVGGLTHGLILEGFGVLAGIDNDPSCKYAYEQNNRTRFIEKSISEVDGRELNALYPNNQHKILVGCAPCQDFSQYTKKSRTGTKWQLLTEFSRLIREIEPDIISMENVPEVRTFNRGEVFNNFIQSLEQLGYHVSHSVVHCPDYGIPQQRDRLVLFAAKQGVIKIIPPTHTPENYRTVRDVIGSLATNYSGGHWEGDSMHAASRLEDINLRRIQHSVPGGTWADWPEELIAECHKKESGESYGSVYGRMEWDKVAPTITTQCNGYGNGRFGHPEQDRAISLREAALLQTFPRSYQFAPEGQLKFKTVSRQIGNAVPVALGRVIAKSIKRFLEGLHERQRVRIII", "function": "A methylase that recognizes the double-stranded sequence 5'-GTCGAC-3', methylates C-? on both strands and protects the DNA from cleavage by the HgiDII endonuclease.", "AFDB_id": "AF-P25265-F1-model_v4" }, { "swissprot_id": "P64315", "sequence": "MSESVSMSVPELLAIAVAALGGTRRRGQQEMAAAVAHAFETGEHLVVQAGTGTGKSLAYLVPAIIRALCDDAPVVVSTATIALQRQLVDRDLPQLVDSLTNALPRRPKFALLKGRRNYLCLNKIHNSVTASDHDDERPQEELFDPVAVTALGRDVQRLTAWASTTVSGDRDDLKPGVGDRSWSQVSVSARECLGVARCPFGSECFSERARGAAGLADVVVTNHALLAIDAVAESAVLPEHRLLVVDEAHELADRVTSVAAAELTSATLGMAARRITRLVDPKVTQRLQAASATFSSAIHDARPGRIDCLDDEMATYLSALRDAASAARSAIDTGSDTTTASVRAEAGAVLTEISDTASRILASFAPAIPDRSDVVWLEHEDNHESARAVLRVAPLSVAELLATQVFARATTVLTSATLTIGGSFDAMATAWGLTADTPWRGLDVGSPFQHAKSGILYVAAHLPPPGRDGSGSAEQLTEIAELITAAGGRTLGLFSSMRAARAATEAMRERLSTPVLCQGDDSTSTLVEKFTADAATSLFGTLSLWQGVDVPGPSLSLVLIDRIPFPRPDDPLLSARQRAVAARGGNGFMTVAASHAALLLAQGSGRLLRRVTDRGVVAVLDSRMATARYGEFLRASLPPFWQTTNATQVRAALRRLARADAKAH", "function": "Probable helicase involved in DNA repair and perhaps also replication.", "AFDB_id": "AF-P64315-F1-model_v4" }, { "swissprot_id": "Q9ZT96", "sequence": "MKIRFCNGFTKPGFLLVHFEPPSFFAVRSRSLSDSTYGNLCNHKKRPGTGIGLTVQCAIANRRFSSRSLDSPRRERSSRSSSSSGRDRDRDKDKGRDSKSLYSRPSLLDMNKEKAANRAKVYEFLRGIGIVPDELDGLELPVTADVMKERVEFLHKLGLTIEDINNYPLVLGCSVKKNMVPVLDYLGKLGVRKSTFTEFLRRYPQVLHSSVVIDLAPVVKYLQGLDIKPSDVPRVLERYPEVLGFKLEGTMSTSVAYLVGIGVARREIGGILTRYPEILGMRVARIIKPLVEYLEVLGIPRLAAARLIEKRPHILGFELDDTVKPNVQILQDFNVRETSLPSIIAQYPEIIGIDLKPKLDTQRKLLCSAIHLNPEDLGSLIERMPQFVSLSESPMLKHIDFLTKCGFSIDQTREMVIGCPQVLALNLGIMKLSFEYFQKEMKRPLQDLVDFPAFFTYGLESTVKPRHKKIIKKGIKCSLAWMLNCSDEKFEQRMSYDTIDIEEVETDPSSFDMNTLMQPEREEESDSEYEEEEDDDDEEFA", "function": "Transcription termination factor required for processing and steady-state levels of plastid transcripts. Required for splicing of the chloroplastic Clp protease (ClpP) group IIa intron. Required for maturation of 16S rRNA and 23S rRNA in the chloroplast. Essential for embryogenesis. Required for the maintenance of the correct levels of transcripts in the mitochondria and chloroplasts.", "AFDB_id": "AF-Q9ZT96-F1-model_v4" }, { "swissprot_id": "A4WLJ8", "sequence": "MRYEVDKRRRIVRVTPERDEDLYFLYLLIDVGDVVRGWTVREYKPDGTKEGERVKMFLGIKVEALEYHKFRGSLRVRGPVVEVEEGIEGVKGRRHTFDIVAGREVEIEKGDEEALEAAEGVLEMAKGILPRILLVSVDDEEAAFAYVTALGVEVLYFLRNDARRGGEEGSLLDEFLAAVGKATENLRRRYNPDKVVLAGPHIILEHVARYVHGDRIPQSSGGLAGVYEFVRRGLYDAFKAEIGFSAYEKLLQLLATNSERVATGPKDVEEAASAGRIDALLVLDSFIKENPREVWAIISRAYKSRSKIFIIREDTEIGVGLRAMGGVAAILRW", "function": "May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.", "AFDB_id": "AF-A4WLJ8-F1-model_v4" }, { "swissprot_id": "A8Z5W0", "sequence": "MSKILCIDYGKKRIGLSITNSIRSIAFGLDTVNSNNIICTLYKYLKYEDIDTIVIGLPIRFDNSLFPIEKDIKKFIKIINNKYPKLIIKRIDERFTSKIANYYLINTRLKINQLKKNQNFLDKDKISATILLQEYIKY", "function": "Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.", "AFDB_id": "AF-A8Z5W0-F1-model_v4" }, { "swissprot_id": "P9WJ44", "sequence": "MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKHE", "function": "Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the toxic effect of cognate toxin VapC20.", "AFDB_id": "AF-P9WJ44-F1-model_v4" }, { "swissprot_id": "P38850", "sequence": "MSTSLLFEQLNFLILVAAEAELPIAHSTRKLLMDNSCNNCQIYELYNENLKDVKTDKDWFMNKFGPQTVHFVISNTINFPFYKIVYFDLLIPVVSHTWVQDSVKTKRHLRTNMYSPNPFHLLRDCQVYISKSSFNKCEYILYSDLLHLLGGTLVNYISNRTTHVIVQSPQDPIIATVSKLTFGSFSSSSTNKHTEKPLREWKFVYPIWILYHFKMAKPLKGELATLCELDMQDTSEEQLFAKWEEVIGDKQTSSSQLTLHPNKTLFKNHHFAISPDLNFFTPLYWFLKGFIEDLDGKVTPLSFSDDLKSVYQAFPDIDCYIGHSANSPILEKTKSIKPEIHVGNVSWLFYMFALQKFTPVSQCKLIHQPFHAKLFTSKELTVAYTNYFGSQRFYIQRLVEILGGLSTPELTRKNTHLITKSTIGKKFKVAKKWSLDPQNAIIVTNHMWLEQCYMNNSKLNPKDSRFQNFKLDDNMGWNIGQIGMDHSSLPTPKNLSMVTYDTQSISEKPPPTNDQMDQINDNTNVLSKKDGTPISSFENSIDEKIDKLQKISGEVAVTHSGDLERSFVSRPSRASFPVVDSKKSNLQKKDSNSDISMETEVFCEGHEKREEKEFTKPITEYDAPKKQEIREQSRKKNDIDYKKEEEETELQVQLGQRTKREIKTSKKNEKEKETNECHIEVDQMTNEKQGEESTGKLISTEDVTSKKDTDKFSHLFEGLSDNDDHINDEKPAVNSKYTTPKTSQNITSGVDTPTTAQTQVFMPSSGNSRLAKTQAAKRLHTDIESLNEFQKNFKRKRIDSEEISLSQDVERSNNNKELATKAEKILARFNELPNYDLKAVCTGCFHDGFNEVDIEILNQLGIKIFDNIKETDKLNCIFAPKILRTEKFLKSLSFEPLKFALKPEFIIDLLKQIHSKKDKLSQININLFDYEINGINESIISKTKLPTKVFERANIRCINLVNDIPGGVDTIGSVLKAHGIEKINVLRSKKCTFEDIIPNDVSKQENGGIFKYVLIVTKASQVKKFTKLINDRDKNETILIVEWNWCVESIFHLNVDFTSKKNVLYQKKNN", "function": "Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.", "AFDB_id": "AF-P38850-F1-model_v4" }, { "swissprot_id": "P22236", "sequence": "MRNYPLKAVCAVLMLGLSACSSLPTSGPTDSAVLEINQGADASELAAKVNVIELNESLVQQIYAAQQSQRFSGFADVRGNGGYAGAVNVGDVLEISIWEAPPAVLFGTTFSSEGQGSGHVTQLPSQIVNKNGTVTVPFVGNISVAGKTPEAIQAQIVASLSRKANQPQAVVKIANNNSSDVTVIRQGSAVRMPLTANDERVLDAVAAIGGSTGNIEDVTVQLTRGNQVKTLAFETLIADPKQNIVLRAGDVVSLLNTPYKFTGLGAVGNNQQLRFSSSGITLAEAIGKMGGLIDTRSDPRGVFVFRYMPFAQLDSKAQQEWAAKGYGNGMEVPTVYHANLLQPETMFLLQRFPIQDKDIVYVSNAPLSEFQKFLRIIFSITSPVTSTTNTIRSY", "function": "May form an ATP-driven capsule polysaccharide export apparatus, in association with the BexA, BexB and BexC proteins. May function as a membrane anchor for capsular polysaccharides. Possible porin properties.", "AFDB_id": "AF-P22236-F1-model_v4" }, { "swissprot_id": "A9GHR9", "sequence": "MSYESVARRYGRAIFEIGKETGTLAALAREIGDASAMYSASEELRLVLDNPLIPEASREELLRELGGRAAFSDVTKNTLLLLARRRRLAALPEIARQLALLVDQDQNVARAVVTSAGPLSDGYLDRLRAELEKATGRKISVTHRQDPSLIAGVVTQIDDQVIDGSLRTRLSSFRDNLLRT", "function": "This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.", "AFDB_id": "AF-A9GHR9-F1-model_v4" }, { "swissprot_id": "Q4L8V4", "sequence": "MKTLIVDDEPLARNELHYLLNEISGFNVIDEAENIEETLEKLLSETYDLVFLDINLMDESGIDLAQKIKKMKQPPHIIFATAHDTFAVKAFELDAIDYILKPFELERIEQAVNKVKHQISNSNEIDHITSEPSTLSMQQDDRQENEDQTVLPIEMNERIYVIRKDDITAVSVNNGITTINTTHRTYQTNEPLNYYEKKLSNNTFIKIHRATIINKTHIDSVEHWFNYTYQVTMTSGDKFQVSRSFMKAFKHEIGLA", "function": "Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism.", "AFDB_id": "AF-Q4L8V4-F1-model_v4" }, { "swissprot_id": "Q96HB5", "sequence": "MEVKGQLISSPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGAGPQLCKPEGLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEALLVDRAAGGGAGSPPAPLAPSASGPPVCKSSEVLYERPQPTPAFSSRTAGPPDPPRAARPSSAAPASRGAPRLPPVCGDFLLDYSLDRGLPRSGGGTGWGELPPAAEVPGPLSRRDGLLTMLPGPPPVYAADSNSPLLRTKDPHTRATRTKPCGLPPEAAEGPEVHPNPLLWMPPPTRIPSAGERSGHKNLALEGLRDWYIRNSGLAAGPQRRPVLPSVGPPHPPFLHARCYEVGQALYGAPSQAPLPHSRSFTAPPVSGRYGGCFY", "function": "Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly. Recruits NIN and CEP170 to centrosomes. Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.", "AFDB_id": "AF-Q96HB5-F1-model_v4" }, { "swissprot_id": "Q9UUJ4", "sequence": "MNGTNTEDNSKQILIQTMYTYDSSGETLKIAIAWKIILKKPKGKNIKDYIEALRKGIEDQEHCEKYASTLLEPRPKTKKDVVLKNSNVTECVALKAKPFSKKIEDMDIFLLTNVHENLQEKRQTSGSLAHLDIEYTFNGLFRFLKCTADIKLKQTKVYEGADFLRIKTLFEEIFMFLKRDCKSPLVLTRLVELGDYVLDLIIITQSIMQNNANNGTGVISRAKFLEFYVFLEQLIFNKLSFASVEQLEKLLDQIVKRMKICFTYCKNDNPSIRLLYSECFFSYAEIYFPCLHSFDAQLSSAASKCVQILRDIITNEELQTDKQELSKSAYSAPSILLIGLKDMLFPEDIS", "function": "Required for correct meiotic chromosome segregation and recombination.", "AFDB_id": "AF-Q9UUJ4-F1-model_v4" }, { "swissprot_id": "O35409", "sequence": "MWNALQDRDSAEVLGHRQRWLRVGTLVLALTGTFLIGFLFGWFIKPSNEATGNVSHSGMKKEFLHELKAENIKKFLYNFTRTPHLAGTQNNFELAKQIHDQWKEFGLDLVELSHYDVLLSYPNKTHPNYISIINEDGNEIFKTSLSEQPPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLEREMKISCSGKIVIARYGKVFRGNMVKNAQLAGAKGMILYSDPADYFVPAVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEHAYRHELTNAVGLPSIPVHPIGYDDAQKLLEHMGGPAPPDSSWKGGLKVPYNVGPGFAGNFSTQKVKMHIHSYTKVTRIYNVIGTLKGALEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRSFGTLKKKGRRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVYNLTKELQSPDEGFEGKSLYDSWKEKSPSPEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKTNKVSSYPLYHSVYETYELVVKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKYADTIYNISMKHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQELDKSNPILLRIMNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDISSKVNASKAWNEVKRQISIATFTVQAAAETLREVA", "function": "Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.", "AFDB_id": "AF-O35409-F1-model_v4" }, { "swissprot_id": "Q9AC16", "sequence": "MIAWTRFRERPWSGPALALIAGLAAALAHPPFGVLPGLLGYAGLLHLLDNADVQRPLRSVFWRGWLAGVGYFGLGTWWVGEAFLVDAATHGWMAPFAVTGMAAGLALFWGLAALLYRALRPASAWRVLTFAGAFAALEWMRGHVLTGFPWNLPGETWKAGSAPSQLAALVGAYGLTWITLAIAGAPAVWRQGRGGRAATGLAVASLIGLYGYGAIALSRPLSPSGPTTVRIVQADIKQDLKWDAERFAQIVQAYVSLTATPYAAKPADIVIWPEGALPAAVNDYLAPGTWVRQAIVDSLAPGQLLLIGGYRYEGAGPHPTYYNSLVALRRTETDLELVGIYDKHRLVPFGEYLPADRFLTVIGFKSLARLSDNFTTGPTPAPLRISPELLVQPLICYESLFPGLAKPDPNVRALINVSNDAWFGVTSGPPQHLNLASYRAIESAKPILRATPTGISAVVDARGRIVPGASLGLGESGVIDAQIPGMGQVTPYDNFGDVAFLALILISGVVSARVRIGKISSSIAPKRKLS", "function": "Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.", "AFDB_id": "AF-Q9AC16-F1-model_v4" }, { "swissprot_id": "Q9Y3B2", "sequence": "MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.", "AFDB_id": "AF-Q9Y3B2-F1-model_v4" }, { "swissprot_id": "P46547", "sequence": "MSSPLHYVLDGIHCEPHFFTVPLDHQQPDDEETITLFGRTLCRKDRLDDELPWLLYLQGGPGFGAPRPSANGGWIKRALQEFRVLLLDQRGTGHSTPIHAELLAHLNPRQQADYLSHFRADSIVRDAELIREQLSPDHPWSLLGQSFGGFCSLTYLSLFPDSLHEVYLTGGVAPIGRSADEVYRATYQRVADKNRAFFARFPHAQAIANRLATHLQRHDVRLPNGQRLTVEQLQQQGLDLGASGAFEELYYLLEDAFIGEKLNPAFLYQVQAMQPFNTNPVFAILHELIYCEGAASHWAAERVRGEFPALAWAQGKDFAFTGEMIFPWMFEQFRELIPLKEAAHLLAEKADWGPLYDPVQLARNKVPVACAVYAEDMYVEFDYSRETLKGLSNSRAWITNEYEHNGLRVDGEQILDRLIRLNRDC", "function": "Higher activity toward long peptides. Acts on hydroxyproline beta-naphthylamide with almost as high an activity as on proline beta-naphthylamide.", "AFDB_id": "AF-P46547-F1-model_v4" }, { "swissprot_id": "Q06629", "sequence": "MSRKNSKKLKVYYLPVTLTQFQKDLSEILISLHAKSFKASIIGEPQADAVNKPSGLPAGPETHPYPTLSQRQLTYIFDSNIRAIANHPSLLVDHYMPRQLLRMEPTESSIAGSHKFQVLNQLINSICFRDREGSPNEVIKCAIIAHSIKELDLLEGLILGKKFRTKRLSGTSLYNEKHKFPNLPTVDSTINKDGTPNSVSSTSSNSNSTSYTGYSKDDYDYSVKRNLKKRKINTDDWLFLATTKHLKHDQYLLANYDIDMIISFDPMLEVELPALQVLRNNANKDIPIIKLLVQNSPDHYLLDSEIKNSSVKSSHLSNNGHVDDSQEYEEIKSSLLYFLQARNAPVNNCEIDYIKLVKCCLEGKDCNNILPVLDLITLDEASKDSSDSGFWQPQLTKLQYSSTELPLWDGPLDIKTYQTELMHRAVIRLRDIQDEYAKGTVPLYEKRLNETQRQNQLDEIKNSVGLTFKKKQEVEKSINDSEKRLKHAMTESTKLQNKINHLLKNRQELENFNKLPSNTISSENHLEEGSALADKLKEYIDKNATLFNKLKELQQANAEKSKLNDELRSKYQIESSKAAESAQTLKILQESMKSLENEVNGPLTKFSTESLKKELERLQNDFQSLKARNKFLKNYITLMNRQYDLKNKNNVQVEKAAANGTRFRSTRSNTPNYT", "function": "Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.", "AFDB_id": "AF-Q06629-F1-model_v4" }, { "swissprot_id": "P64304", "sequence": "MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPATLGTKPTLLIWGMKDVAFRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAIIERFG", "function": "Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.", "AFDB_id": "AF-P64304-F1-model_v4" }, { "swissprot_id": "Q6MWE5", "sequence": "MAAATDGGGLPLLADKAASHSHHHHPERHFTSGEVVRDVIMGVSDGLTVPFALAAGLSGASAPSSLVLTAGLAEVAAGAISMGLGGYLAAKSEADHYQREMKREQEEIIAVPDTEAAEIGEIMSQYGLEPHEYGPVVDGLRRNPQAWLDFMMRFELGLEKPDPKRAIQSALTIALSYVIGGLVPLLPYMFISTAQNAMLTSVGVTLVALLFFGYIKGRFTGNRPFLSAVQTAIIGALASAAAYGMAKAVQTR", "function": "Vacuolar iron transporter involved in the transfer of iron ions from the cytosol to the vacuole for intracellular iron storage. Vacuolar iron storage is required for seed embryo and seedling development (Probable). May be involved in the regulation of iron translocation between flag leaves and seeds (Probable). Can transport zinc ions from the cytosol to the vacuole.", "AFDB_id": "AF-Q6MWE5-F1-model_v4" }, { "swissprot_id": "P10577", "sequence": "MTGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAEKEGLDVKRFDQEALELMKAHPWPGNVRELENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVYRSSRSA", "function": "Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.", "AFDB_id": "AF-P10577-F1-model_v4" }, { "swissprot_id": "Q93899", "sequence": "MQSFDIESLIGVNKVPSLVEMVAASRASSFSPPFEQQHHDPMGVVAAAAAAAAAGRHHPYDNRDDGQMRRYRTAFSREQIGRLEREFAKENYVSRKTRGELAAELNLPEGTIKVWFQNRRMKDKRQRVGGLAWPFPPQMAAYMLNPFAYEMWMKTAAASQFGATGPGNGAYGNNGSSTSPSAAGSLPFLPPLGFPSFLSQNSTKSPSSPHSDDSSKSKNTSSDDDESKPVNFSNSPSSSSPSPYSTD", "function": "Transcription factor. Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons. Probably acts by binding to specific promoter elements. Required for posterior-specific pattern formation in the embryo and may have a role in regulating egl-5 expression.", "AFDB_id": "AF-Q93899-F1-model_v4" }, { "swissprot_id": "P33342", "sequence": "MAAIPWRPFNLRGIKMKGLLSLLIFSMVLPAHAGIVIYGTRIIYPAENKEVMVQLMNQGNRSSLLQAWIDDGDTSLPPEKIQVPFMLTPPVAKIGANSGQQVKIKIMPNKLPTNKESIFYLNVLDIPPNSPEQEGKNALKFAMQNRIKLFYRPAGIAPVNKATFKKLLVNRSGNGLVIKNDSANWVTISDVKANNVKVNYETIMIAPLESQSVNVKSNNANNWHLTIIDDHGNYISDKI", "function": "Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.", "AFDB_id": "AF-P33342-F1-model_v4" }, { "swissprot_id": "P29369", "sequence": "MYKILIADDHPLFREAIHNVIADGFPGSEVMETADLDSALGLTQEHDDLDLILLDLNMPGMHGLNGLMNLRNEAPTIPVVIVSAEQDKQVVLQAITYGAVGFITKSSPRAQMTEAIEQILNGNVYLPSDVIRTQKSSPRRSGHEEHGISPELLQALTRKQLLVLERMTKGESNKQIAYNLDIAETTVKAHVSAILRKLKVHNRVQAILSAGDIDFAAYLRR", "function": "Positive activator for glycerol metabolism.", "AFDB_id": "AF-P29369-F1-model_v4" }, { "swissprot_id": "Q5KTS5", "sequence": "MASGGQFPPQKQESQPGKEHLMDPSPQHASPHYKPANKLQGKVALVTGGDSGIGRSVCYHFALEGATVAFTFVKGHEDKDANETLELLRKAKSSDAKDPIAIAADLGFDDNCKKVVDQVVNAFGSIDVLVNNAAEQYKASTVEDIDEERLERVFRTNIFAYFFMARHALKHMREGSTIINTTSINAYKGNAKLLDYTATKGAIVAFTRGLSLQLISKGIRVNGVAPGPVWTPLIPSSFDEEEVKQFGSEVPMKRAGQPYEIATAYVFLASCDSSYYSGQVLHPNGGAIVNG", "function": "May act as a short alcohol-polyol-sugar dehydrogenase possibly related to carbohydrate metabolism and the acquisition of desiccation tolerance. May also be involved in signal transduction.", "AFDB_id": "AF-Q5KTS5-F1-model_v4" }, { "swissprot_id": "Q7VG35", "sequence": "MFGVGIFEVLVILIVAVIALGPNKLPQTIVDIVKFFRAVKKTMAEAKETFDKEIQLSEIKQEALKYKDTLESEVNKLTKDIRLDELREISVDSLTKPLQETKEVLSEEAKNLQSTLESLNSDISYESSAAAQTPTTQESIPTDSTREIAYATQKPQNSIDSINSKESSVDSLHSPSIVESTQSSSSKDS", "function": "Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.", "AFDB_id": "AF-Q7VG35-F1-model_v4" }, { "swissprot_id": "Q9LZP9", "sequence": "MATIATGLNIATQRVFVTSENRPVCLAGPVHLNNSWNLGSRTTNRMMKLQPIKAAPEGGISDVVEKSIKEAQETCAGDPVSGECVAAWDEVEELSAAASHARDKKKADGSDPLEEYCKDNPETNECRTYDN", "function": "Acts as a linker essential in the assembly of a core complex of PRK/GAPDH. Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues.", "AFDB_id": "AF-Q9LZP9-F1-model_v4" }, { "swissprot_id": "P0CM12", "sequence": "MPAPVPPTAFAQPSGPATQLVLGSMQRAPEYQALLTSLKSAAPPSSSVQGEMVDRILDNATTLPPPPLTIHLVLPLPLPSNLLSAIPPSTQIFIHIPADSESQLGALHSALASHSFTPVLPTPSPSTLAYTSPSAPSLPAVASEPSPAPSSSTPVTLSGARPLQLRRNGDKARKAALWAIDSPLIPDGGKSLLTPADRTRPDCVFPAENGKPVKRRRACKDCTCGLKELEQEEEAQTSAAVQEAQKAFFLEGDDDIPENLKKATEGMEGIWPADKRAEAKKTSSCGSCYLGDAFRCSSCPYLGLPPFKPGEQVQVSIGDDI", "function": "Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.", "AFDB_id": "AF-P0CM12-F1-model_v4" }, { "swissprot_id": "O83323", "sequence": "MKRVINSCIAVLLGVAVMSAVIVLCSENPSVSLAAFFLKPFSTRGYIRALFHKAGLFVCMALGASCALKTGMINLGGDGQIYAAGFVTALLLREYWGVGFLLQWSVALLCALSVAGILACVSGILKAWLATSEMITSFLLSTACVPLIDALIITVTRDPAGNLLATAPVHSHFILQQQTSLFGVPAVLTYASLVALAVGCFFSYTRVGYQFRICGKAPEFGRFVGFPVWATYVWGMVLSGALFGLTGFFSVVGLFGTCYVGFSVGMGYAALAHALIAHAHITVLVPLAFFFAWMETASEAAVLGAHLTVNVVLFLQAAIFLLISAQWSAPWNAVRRGARRVYRFLVTVFCFRGEKHRTRRRHALSVHDTHHRRSRWE", "function": "Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-O83323-F1-model_v4" }, { "swissprot_id": "B8G7S5", "sequence": "MRRANRLRRPAQFRRVRQTGRTFSSAWLTLTVAPGRRDGVRCGFITGRRLGKAVQRNRARRRVREAVRLLLPSLTTGYDLLFAIRSPEVIEAPFSQLQADIIRLLRQACLLTTPETEPVSPVSPTSLPQNERGSP", "function": "RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.", "AFDB_id": "AF-B8G7S5-F1-model_v4" }, { "swissprot_id": "G5EDT6", "sequence": "MENVCFQQRLRDLETRVRKWKFLKLGLTEVRLRPRDRRSTSVDQKHKECSSTSSSPQHQRPNNIGYLTSPMERKFTPLSMKPSPSRRDTEKDALEYEFLEGYKKSGTLEIDGEKQVVDPNEIHIISLLGSGSCGVVESATVRSKLMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTGLYPFPLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFYLDYDPASGSAYKFKAINGKCNQVADWFVDVIRLSKTEDELKSIPNTPCVN", "function": "Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy metals such as Cu(2+) and to arsenite.", "AFDB_id": "AF-G5EDT6-F1-model_v4" }, { "swissprot_id": "Q9WVJ0", "sequence": "MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDNWKERGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYVGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIESSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPQREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLGAGGVSAEVDTSSLSGDNTLMSTLEEKETDGEQGHTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEAGPSAHPRSLDGLQLPPMPWNVPPDLSPRVVDGIEDGCSSDQPKFSFRVGQSGPECSSSPSPGTESGLLTVPLGPSEARNTDTLDKLRQAVMELSEQVLQMREGLQSLRQAVQLILVPQGEGQCPRGSGEEPCPATASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGQPPPLMAPWPWGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPSEEGARTGTPAPVSQAEATSTGEPPPGPGGRALPWDPHSLEMVLIGCHGPGTVQWTQEEGTGV", "function": "Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.", "AFDB_id": "AF-Q9WVJ0-F1-model_v4" }, { "swissprot_id": "E0SDG7", "sequence": "MLAWNNLVEMLGCSKASNEFIYLPQKLNELPVFEEGVLGDRSYYSFFNSGVLFLLEDDLVNQISLYIQADEGFSAYTGELPLPVNSRESEIIQVLGTPSGSGGGKMDMLLGYVNRWIKYKTESHTLHIQFDQNDQLCRVTLMQ", "function": "Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the DNase activity of CdiA, its cognate toxin protein, but not against non-cognate CdiA from E.coli strain 536 / UPEC.", "AFDB_id": "AF-E0SDG7-F1-model_v4" }, { "swissprot_id": "Q9P4U6", "sequence": "MRVPIAVQLGLLVLLTALAGLAALAIATWINNYNFVVDVKSQSLQLVASIKSSQITSNLDLLETTSKTIITRILIQSALQRYYAGNTTEENFASSITDVQSALGSRGYLSLYQASIYARNVENGESKARRLLNVTSDEVPEIRLPYDHPNGTAVMLGDEGLGYPPSLYPNLTEDATTNKLYAFDGVPITTNQPLLLGPLATNDSFSLISLSLPIINNTSAADILGYITVVASAANLQDAMSSRQGLGSSGQVLLLAPSRPENRFPTGSRPATATSEPQIAGLDNQEVRYVFRPTPLPGNKRRHSPAVASGASFPLRDYPIALKVLNQPYDSINHSITDLSSKNENGTRVAVGAIQQRSDLVEWVLIIEETHGEAFAPVSRLRKIILACVFGTAGVIALLIPPLAHLSVAPIRRLREATRKSVNPTIGPLSPSLSTMVDPIEISMHNGNEKSEKGGFFNRLKRGRGNLATGHDRDNEPHQFQIPGRVKERKHIITDELTDLTKTFNEMSDELVIQYNRLEERVAERTRELEKAKIAAETANESKTLFIANISHELKTPLNGILGMCAVCMGEDDLPRIKRSLQTVYKSGDLLLHLLNDLLTFSRNQIDQAIRLEEKEFKLSDIRSQLQIIFQNQVQEKQISFSIKFCHPDTPPINDTPEVISRAPGPVYGPPGTAKLKDMVLWGDQHRILQILINLVGNSLKFTPEQGTVAIRIKCVGEEKNPSASPRPESRALSRWRSIGSSHASSRPKTSLDRPRDGGDEETTRPPNLRTLILQFEVEDTGPGIPQHLQNRVFEPFVQGDLRLNRKYGGTGLGLSICSQLARLMRGQIQLNSEQGRGTLFLVRIPLGFVKESPPSTASSMTSLAGSRTSSVFSLDDLASVTKAPSNHSVASQHESTKSNAEIQDSQPRLVGLSQPFFAPPVPQAKDNGLKKIRALVAEDNVVNQEVVLRMLALEDVYDVTVVKDGQEAYDTVKANMEEGKVFDLIFMDIQMPNLDGIESTRLIRQMGCSAPIVALSAFSEDSNIKDCMNSGMDMFISKPIRRPALKQVLRRFTPIPEEAEKPQM", "function": "Nonessential protein which may be part of a two-component regulatory system activated by changes in the extracellular environment.", "AFDB_id": "AF-Q9P4U6-F1-model_v4" }, { "swissprot_id": "A0A455M7S4", "sequence": "MDVAAQHVFLFGDQADAPMPMVRRVVERSRHSKNLESFLQSAIDNVQLEVARLTPAERDTIGPFHSLEGLADSLKEKSDRHGIAQMVSVFIARIGELILHAENDPALLDSSTPLLSLGICGGLLPAAAVAAATNIHELIEVASYLARVNCRVAVAISRRSIEIESGPGSWAFSVLGSAVAQLPDILEDFHREQSIPRHRRAWIAVSTPTWATVFGPPSVLSKLRETSITLKKSDAAELPAFGAVHAAHLVAPNFGDLVGESPLLNRPLKTGYKLLSGSKYAPYNATTLKDLLPQIMLDIFQNETNPARVFDVGGSYLRKGGPISLYMLGATSYLVLLRRSLHTQKFEVNLKTNPPSLQNSELRGGSGSVAVIGMSGQFPGAASVDELWDVLMRREERHRKIPIERFNADDYLDETGRGSSAITTAYGCFLENPGLFDHKMFNVSPREAMQMDPGQRLLLHGVYTALEDAGLVTGSSTAADNKRISTYIGDGSDDWRDLQSQHGVDKYIVQGTQRSFTPGRINHHFKWEGATWLVDAACGSTASAVGLAYRALINRDCDTAVAGGANIIATPFWHSALSKGGFLSKTGGCKTFRADADGYCRGEAVGVVVLKRLEDALQDNDNIVSVIRGYSRNHSADTVSITRPHVPAQMRAYQAVLHNSGLEPEDISYVEMHGTGTTAGDSAELESIVNVLAQKNTRETPLVVGAIKANLGHSEAASGISSLIKASLTFRKGMVPPQVGIPEKMGSFACLDHGTVHVPGAPVSFTRESVGKTRAMVMNNFDAAGGNSCFVLEEPPTPSLKSADPRPYHVVTVSAHCQTSLEENKRQLLQFLTENKETSLADLSYTTTARRMHHTLRSAYTGGSIQDIINSLGRDLGKNHGQDKPGAPRVAFAFTGQGAHYAGMGADLFKVSQPFRTTITGLQKICVTHGFPQFAHLISDPSTPMENVSTAQIHLSLAALEIALVDLWKILGISPDLVIGHSIGEYAALYAAGVLSATDAMYLVGTRAMLLQDSLEEGVNGMLSISGTPQDVAAIVSDESVMADCEVACHNSPGMVVLGGRRPRLAELEELLRARKFKCKLLDVPYAMHSSQLDTILPGFRKAARGVCFGTPTIKVISTLTGTEQQHFDSEYLVRQTRESVKYTQAISHCLSQGLVDSATLWLEIGPGPVCLGLIRSNTNVATNLAMPSLKKDDQNWKSISSALASLYVAGKAIGWREYHSDFIDSLSLISLPSYAFDNRNFWMPYTTGGKHQDVQPISTCLHHLVSQDDNGKEQSATFTAVVSQPSLLKMIQGHKLSGITVCPAGVFAEMALTAARYVLTGGSFSAPVPSLSVIDIQIDHPITPQSGSQQVIQVNVRRPKQSRDFAVSIVDQAKPSLITAKCCIRQTDEQDVIATRRQQLDMIRPKISKLMQDAASGIANRFQGKLFYKLFANLMDYGGQYEGVKEAIVGDDFTEALATIRLPKAQDSNESCTLSPYWIDALTHLVGFLLNGNPMNSGDDVYIGTQMERMEILAKDFSPDVVYQSYAYLEPSQDSVNYRGHVYILSGDSIVGFLEGARFRKMPRTTLHRILGKAVPPKPAKETSHPSVEATAPATTNGRSSATNAQAEAPAPPVNGSNGHRKTVESVLIACLIEETGMEESEILPSTFFAEIGVDSLMSISILSEIKNETGVELNASFLMEYPTLGDAQRQLRTLERKREGANPSTNGTDVAVVVNGEKPAKPKRECNVVLMQGQAPEDSSSIPLFLLADGAGSAAAYIHLPKLGLEDDLAVYAVESPWVRDPAEFTCSFEEAAALYLAAVRAKQPRGPYLLGGWSGGGVFSYEVARRLLAAGERVLGLVVIDIRAPSLRPNPHAAAPTMDIIDQIGMLSGIERTFADDASPEAARLKRHMLSTVTCFSRLVPTPMPPHLRPERTFVVWAKKDVLPKAAYDQLPPGLDAWFYPASHDMGPNGWDELVGDAVEYSQVEGDHFSIMTFPEVTELGRVLQAAVAKCRV", "function": "Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids arthripenoids. The pathway begins with the HR-PKS atnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS atnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of arthripenoids. The FAD-dependent monooxygenase atnJ then performs an oxidative decarboxylation at C11 of the atnH/atnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation. The membrane-bound polyprenyl transferase atnF then introduces a farnesyl group before the FAD-dependent monooxygenase atnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by atnA. The terpene cyclase/mutase atnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation. The cytochrome P450 monooxygenase atnM is responsible for hydroxylating both C1' and C10' (Probable). The next steps may involve ketoreduction and acetyl transfer by the ketoreductase atnB and the acetyltransferase atnC, and lead to the production of arthripenoid B, the final biosynthetic product of the atn cluster. The hydroquinone moiety in arthripenoid B is prone to undergo spontaneous oxidation to afford a benzoquinone compound, a key intermediate for generating structure diversity (Probable). For instance, addition of a cysteine followed by ring contraction gives arthripenoid A, tautomerization gives the main product arthripenoid C, addition of a molecular of water or amine affords arthripenoid D or E, respectively, and loss of one water forms arthripenoid F (Probable).", "AFDB_id": "AF-A0A455M7S4-F1-model_v4" }, { "swissprot_id": "P38051", "sequence": "MQSLTTALENLLRHLSQEIPATPGIRVIDIPFPLKDAFDALSWLASQQTYPQFYWQQRNGDEEAVVLGAITRFTSLDQAQRFLRQHPEHADLRIWGLNAFDPSQGNLLLPRLEWRRCGGKATLRLTLFSESSLQHDAIQAKEFIATLVSIKPLPGLHLTTTREQHWPDKTGWTQLIELATKTIAEGELDKVVLARATDLHFASPVNAAAMMAASRRLNLNCYHFYMAFDGENAFLGSSPERLWRRRDKALRTEALAGTVANNPDDKQAQQLGEWLMADDKNQRENMLVVEDICQRLQADTQTLDVLPPQVLRLRKVQHLRRCIWTSLNKADDVICLHQLQPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQQSEFCVSLRSAKISGNVVRLYAGAGIVRGSDPEQEWQEIDNKAAGLRTLLQME", "function": "Catalyzes the conversion of chorismate to isochorismate. Can also catalyze the reverse reaction, but with a lower efficiency.", "AFDB_id": "AF-P38051-F1-model_v4" }, { "swissprot_id": "P0A952", "sequence": "MPSAHSVKLRPLEREDLRYVHQLDNNASVMRYWFEEPYEAFVELSDLYDKHIHDQSERRFVVECDGEKAGLVELVEINHVHRRAEFQIIISPEYQGKGLATRAAKLAMDYGFTVLNLYKLYLIVDKENEKAIHIYRKLGFSVEGELMHEFFINGQYRNAIRMCIFQHQYLAEHKTPGQTLLKPTAQ", "function": "Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine. It can also use spermine.", "AFDB_id": "AF-P0A952-F1-model_v4" }, { "swissprot_id": "Q02803", "sequence": "MYEVIQKRKTKIINVLQSPELMRLIEDPSNLGISLHFPVSSLLKSNKCTPMPKLSTYSLASGGFKDWCADIPLDVPPEIDIIDFYWDVILCMESQFILDYNVPSKNKGNNQKSVAKLLKNKLVNDMKTTLKRLIYNENTKQYKNNNSHDGYNWRKLGSQYFILYLPLFTQELIWCKLNENYFHVVLPSLLNSRNVHDNHSTYINKDWLLALLELTSNLNQNFKFEYMKLRLYILRDDLINNGLDLLKNLNWVGGKLIKNEDREVLLNSTDLATDSISHLLGDENFVILEFEC", "function": "Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC/SPE1 monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.", "AFDB_id": "AF-Q02803-F1-model_v4" }, { "swissprot_id": "O05250", "sequence": "MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKATALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPDPSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVNEIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAMLESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKKPLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLGKQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMSMRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMILTSEKNEGTTFSIRIPYEPKEENHD", "function": "Member of a two-component regulatory system MalK/MalR. Involved in the activation of maeA, maeN and yflS in presence of malate. Probably activates MalR by phosphorylation.", "AFDB_id": "AF-O05250-F1-model_v4" }, { "swissprot_id": "Q4V5R4", "sequence": "MEPKSQDQAPNRDDPDLQTEPLTIAQSITSFYMYNPYEKRSVEVPLTNCDAFISLLKCVIGTGILAMPLAFRCSGFVMGTVMSILLMILLTYSIHLLIADMTECCRRRRVPQVSMPEAVRIAYEEGPKWINCFGRAAGFMTTCVLVFGQFLLCTVYLVFVSKNFKEIGDHYIERYNERYYVLVACLLLLPLFMIRRLKYLVPLNLISNFLLYAGFALIMYYLFNGLPNINDREMVTPPVEWIEFIAIAAFSLTAVGSMLVVEAHMAHPQSYLGLFGVLNLAVLFILLSNMFFGIIGYWRFGDNVHASITLNIPQDEILSQFIKVFIASGIFLSYPLNGFVVITVMFSDYENSEPRGRYRTLIEYVVRLLFLFLTGAVAIGVPNLAALTELEGAFSLSNLNLLCPALIDVFLNYNVGYGRLMWKLIRDILLILIGLIFGIVGCTVALMQLIRDFQLTLNSM", "function": "Probable glutamate transporter which transports extracellular glutamate into the cells. Regulates the production of intracellular reactive oxygen species (ROS) probably by controlling the synthesis of antioxidant glutathione. By regulating ROS production in blood cells, required for maintaining bacteria phagocytosis following infection with S.aureus and possibly E.coli.", "AFDB_id": "AF-Q4V5R4-F1-model_v4" }, { "swissprot_id": "Q8MMF9", "sequence": "MPEKMSLRLVPHLACIIFILEIQFRIADSNDPCPHNQGIDEDIAESILGDWPANVDLTSVKRSHKCYVTCILQYYNIVTTSGEIFLDKYYDTGVIDELAVAPKINRCRYEFRMETDYCSRIFAIFNCLRQEILTKS", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.", "AFDB_id": "AF-Q8MMF9-F1-model_v4" }, { "swissprot_id": "Q7KWK5", "sequence": "MICAISGSTTEEPVISTKTGNVYEKRLIEKYIDTNGKEPTTGEPLGLSDLITVKIGKTVKPRPTTATSIPSMLQLFQNEWDSLMLETFTLKQQHETVRQELAHSMYQYDAACRVIARLVKERDAARSALANARNIVQQQQQQTNNNNNNNNNKDVEMSSASTPSSSEDNLLDSTIYKRIAEKSEELIKTRKERTHQSLAEPDAIKQFKVSANVETDCQIKSLEVNSQDNNLIAMGGINGNVYVYSRETNELCTAIKGTSSAPINKVLFAPNNTIVSAGSDAVIRVVKGGESPSKKTYTQYKSTYQFAHKASVTDISLHVLGDYIISSSLDKSLNMYDIVNGTHLTSFGQSQQLCYTSVAFHPDGMFFAAGTQNGVVKIFDLKSKVNSFNFQGLSTAVNCISFSENGYYLTAADNNTVKLFDLRKAATKNSPDIQTITLDNQQIKSINFDYSSQYLGVASSNQINLYSCKSKQKPPISSIHSIDSDCLDFKWARPNSNFFVTSSSSKNIVNIFSN", "function": "Probable ubiquitin-protein ligase mainly involved in pre-mRNA splicing and DNA repair. Core component of the Prp19 complex/PRP19C/Nineteen complex/NTC which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity.", "AFDB_id": "AF-Q7KWK5-F1-model_v4" }, { "swissprot_id": "P0AD15", "sequence": "MYDFNLVLLLLQQMCVFLVIAWLMSKTPLFIPLMQVTVRLPHKFLCYIVFSIFCIMGTWFGLHIDDSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSMGGMTALSCMISTIVEGLLGGLVHSILIRRGRTDKVFNPITAGAVTFVAEMVQMLIILAIARPYEDAVRLVSNIAAPMMVTNTVGAALFMRILLDKRAMFEKYTSAFSATALKVAASTEGILRQGFNEVNSMKVAQVLYQELDIGAVAITDREKLLAFTGIGDDHHLPGKPISSTYTLKAIETGEVVYADGNEVPYRCSLHPQCKLGSTLVIPLRGENQRVMGTIKLYEAKNRLFSSINRTLGEGIAQLLSAQILAGQYERQKAMLTQSEIKLLHAQVNPHFLFNALNTIKAVIRRDSEQASQLVQYLSTFFRKNLKRPSEFVTLADEIEHVNAYLQIEKARFQSRLQVNIAIPQELSQQQLPAFTLQPIVENAIKHGTSQLLDTGRVAISARREGQHLMLEIEDNAGLYQPVTNASGLGMNLVDKRLRERFGDDYGISVACEPDSYTRITLRLPWRDEA", "function": "Member of the two-component regulatory system BtsS/BtsR. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation.", "AFDB_id": "AF-P0AD15-F1-model_v4" }, { "swissprot_id": "F1R983", "sequence": "MSITPADLSPASSSDHREKLQELLTAVRDLHDTALQELQAKIAKLKKERCLDAQKLSEFHSKNQHLREQQKIQQEKIRQLEDRLRSGPCDRCTVKEKQIKKTNTELEDNNQRNLSVISELEAERKTLTDENRRLSLELERLRRSGSPQNTSSEAEEGMIPDSPLRPLSLPVASKMKRRKEQNHVRYTETPLSLSHPESRQREQSVAFGCNGKGVLVAETCEMDATSVAERDNKRHFRIVVPETCRPDVYPEQVDDVDDDDLHIPSHTEQNQKPELRDCTNILIAGQNDDSPLILRCRPLASQDHQSSIDDVLRTPANSSTCVLTKGKRKHSNGAKKDREISDCRLDADETDIKGIIFASTPANGRLQSKNQETSEIETTQDSKKKCLDGHTPRKSLVQNHHAPFPYDQSWSVDPGADLGQYDTESSPQPEHQARTDLETLDTDCTFVSHSLLLRGQKTTGQSQTTGIGQKANDSLADIFDKTGYGEYESCPQDDSIDLKQDSVYEEEREEDDPEEKPEAAVVFRRPADRKPLVSDSDKSSRNKSFACVEVVRKKDERRKLKGHYCKECEVYYADLPEEEREKKLTSCSRHRYRYIPPSTPENFWEVGFPSTQTCVERGYIKEDEQPDVRIRRRRPYLAMFSPKAKSQKKKH", "function": "Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA.", "AFDB_id": "AF-F1R983-F1-model_v4" }, { "swissprot_id": "C4ZJU1", "sequence": "MRLSKLKLAGFKTFVDPTTVLTPGNLVGVVGPNGCGKSNIIDAVRWVLGETRASALRGESMQDVIFNGSTTRKPVSRASVELVFDNAEGRAAGQWSRYAEISVKRVLDRSGESTYYINNVHVRRKDVIDLFLGTGLGPRAYAIIEQGMISRIIEARPEEIRGFLEEAAGVTKYRERRKETEGRLRDARDNLARLDDIRMELGERIVHLEAQAAVAARYRELDAAHVEKQQLLWLVKRNEARAEQARVAASLNEASSRIEADSARLQELETSVESRRDAHFEASEAVHVAQNDLFAASAEVARLETELQHLGEARRRLEARLAQLELDRGHWSSRRETLAADRARWQELAENAALRAEHAEARHLEIADRLPELDSSRQGADATMAAARRELAQTEQQLRVEETKRASALRALEALQQRRGRLEGERGGIVGPDERVLAEREARLEALQDELEVHQQELAAAQPRLPDAQAALKAALEHERAVQRRLTELRARRDALMQLQARVQSQGKLGDWLERHGLDQLPPLWKQLQVAAGWDEAVQAVLRERLAALTSPDPALALAAARTVLDETPPESLAIALPARSGAPAERANCAQGPLSPQGRVTVATTATESSTAIATDVAPAVLALAGLVEVRDPALRALVDDFLAGAWAVERLEDWLPLRAQLAPSTCLVGPRGQVLTRDALVHHAPDARTHGVIERQREIEGLSAELQAHEDEAHLAHDALVVAESAASALQERINGLRRELQTIQAQVHAEQVEVLKLAQARARAQERREQLARDLEDIVHLESAEREHLTRAELEQARAAELAELQRERLDAATEVLREREHAVREARALEQSAARELQEARFSERECAGKLEDIARNQQLAGEQLERVVAELAARAAELDATDDHRSAEALQEALALRGRREAALAARRDALAEAAAALKQVEELRLRTEHEAAPIRARVAELRLALQAAELAVAQFEERLVEARADEAALAPLLAAEPKESTLQREVARLAREIAELGAVNMAALDELTTASERKGYLDAQTEDLLQAIDTLEDAIRRIDRETREQLQDTYNTVNRQFGALFPQLFGGGRAELVLTGEEILDAGIQIVAQPPGKKNASIHLLSGGEKALTAIALVFSMFQLNPAPFCMLDEVDAPLDDTNTERYANMVKRMSAQTQFIFISHSKITMEFAQQLVGVTMQEQGVSRVVEVDIEEALRLADPAAA", "function": "Required for chromosome condensation and partitioning.", "AFDB_id": "AF-C4ZJU1-F1-model_v4" }, { "swissprot_id": "Q54HM6", "sequence": "MSRLFNNFLLKTNKNQFIQSFSTKSQINNNIFNNLIKNEKISLPPPPFLSSSSPLSMNNIFNRNNKNLYTTNNFNYNKLQFTTQSPNPTPTPTPTPTPTPTPNNNENNNNKNNNNNNFKEEQKKILQEKNKAIGLYVLIAIIGILGLSYAAVPLYRIFCRATGYGGTTRDADDFDVIRKRNLDRTVYPIKVTFSASTANKIPWTFKPTQSTIECLPGEPVLCFYRATNNTDTPIIGVATYNITPMKAGTYFTKIQCFCFDEQRINAHETIDMPVLFVIEPELLDDKNMKGVSDITLSYTFFKSNDQGEYEEI", "function": "Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.", "AFDB_id": "AF-Q54HM6-F1-model_v4" }, { "swissprot_id": "Q75QN6", "sequence": "MAEPEKKRDQPFSQEKDEEKDLYLVHDEHESPLPLTVTSRVLYMLGDIASGPAYRFTQWLDLVRKRSATYGSSGFPHRLHRIDDMVTSAGERNTDPKSPPSRQSSEISLWERLGKASTVDIDSSCFSWNMLSSLHHTEHSSSTDHSEEDQSKPLEVTVNSGGVVFFALFNSSSSEDASRKEEAAVIKFASSRMATQSERLGYEFSKWLGVQIPQARVIHSCNPEWTLIKEATEKAQAKATSEGDEVGEMTCSELLEALELSRCLLLMSYVHGCPMLESMSSFETEEKAERAAAALGRILVLDLVIRNEDRLPCRQLRWRGNPANLLLTDRIVSSAKHHECSFDEAFDSAIKRYHPKDYRSIQRERRASSVDSRSRLSISDQMLVSQASDFSDITESPRSYDTGLMSPMSDRSVAADFHLVAIDSGVPRRPPAGKRASDQEIYPRLVELLLNSSQYSSNLLHEITEGSLGYPQAEDGEETSNVRSVVTPVVREFRNGFRAGLRDLQEFHIFLVTLHQKLDVLLRAFFSMMDKTMCADFDREDFAVPESPSHTHGHEVNHYPSPSKDRVPSDNSSDHSESDMQKSVPRTPNSENKEDGSSPKSRESWHGRSGKGGESLSSQRLAAKLRDFHKFAKVDAESNKELDQWNETLRNEVMKLCQENGFNTGFFEGSDNNSCTDAYELKVRLEHILERISLISKAANTEKPSMIQENLFIGGGLAARSIYTLQHLGITHVLCLCANEIGQSDTQYPDLFEYQNFSITDDEDSNIESIFQEALDFIKHGEETGGKILVHCFEGRSRSATVVLAYLMLQKKLTLLEAWSKLRKVHRRAQPNDGFARILINLDKKCHGKVSMEWRQRKPTMKVCPVCGKNAGLSSSSLKLHLQKSHRKLSSGSVDSAMNMEIQKALEALKLSTGRGSSASSNSFQSHPG", "function": "Probable dual specificity phosphatase that binds and dephosphorylates MPK18, modulating the organization and dynamics of cortical microtubules. Acts as negative regulator of abscisic acid (ABA) signaling during seed germination and light-induced stomata aperture.", "AFDB_id": "AF-Q75QN6-F1-model_v4" }, { "swissprot_id": "Q9SW00", "sequence": "MAEEEMRKHLVLAKPFSLEDEKDSEHTASNVIRKILSLFKTVRPGSDLTNFQLPPQLNLPRSQLQCYGEMVYSFVGQDLLGECSRRDLPIERLKSVVTWNISTLRPVVFGMSPYNSVLGETHHVSNGHINVIAEQVVHHPPVSALHATHEQENIDVTWCQYFTPKFRGTHVDVEVKGKRVMKLLNHIETYEMDQPRLIMRFLPAPGAYWAGKVKIKCPETDLEAELHLISDSFIERFRGNNNRSIKGKIFESSSGNQLYNIFGHWDRTVMAKNIKTGELEVIYNAKENITGLKPPTVKNLEEVTESESTMVWSEVSEGILKKDWERAREAKIVVEEKQRASLKQREASGESWVPKHFLVVKDGKDWDCSPLQPTVPPAPLVIT", "function": "May be involved in the transport of sterols.", "AFDB_id": "AF-Q9SW00-F1-model_v4" }, { "swissprot_id": "P42226", "sequence": "MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW", "function": "Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.", "AFDB_id": "AF-P42226-F1-model_v4" }, { "swissprot_id": "Q18486", "sequence": "MAAKRPPASTLKWCQQEMGPICEGIGMVVRSQIGYDGRRIEKQIRRKALQTVVMGGQDVDPLKEPNKTNAPLLSPTLPSTNEALQRARVVAAGIETFAKLMSQGTYPGSAGFTVSETGERKYMKQTSPVQSNIVANLMATADKLSKGVISLAPFPLPTITKLGTWVIANPTAQLPIPPQLKSAIPAIGQIETLIQSILGVQGPVSSVSRAPRKLKLEGVTDQVVLEPETIHATVDVEPIDKTLTKEEAEFLIKAARSVDDDNAETAIFGTQKAKPKVYRPELPKNFEVNLEMGNVHTLTRSNESSVPATRIGRLATFGQLAFGLLGGATAEVTRRTFGIGKRLQEEGIPKNPFLSEANADRIVATLCRVRGAALKLGQMLSIQDSSTVPPALLQIFERVRQSADFMPIKQVHRQMKDAFGDDWREKFEHFDDKPFACASIGQVHKAVLKDGRNVAVKVQYPGVAEGIDSDIDNLVSVLSVGGIFPKGMFLDAFVGVARRELKQECDYEREARAMKKFRELIADWQDVYVPEVIDELSSSRVLTTELVYGKPVDACVEEPQVVRDYIAGKFIELCLKEIFLWRFMQTDPNWSNFFLGKHPKTGEPRLVLLDFGASRAYGKKFVDIYMNIIKSAYDGDKKKIIEYSREIGFLTGYETSVMEDAHVESVMIMGETLASNHPYNFANQDVTMRIQKLIPVMLEHRLTSPPEEIYSLHRKLSGCYLLAAKLKATVSCGGLFHEIHENYVFGEDGIDINID", "function": "Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway.", "AFDB_id": "AF-Q18486-F1-model_v4" }, { "swissprot_id": "O53423", "sequence": "MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSFDAPPRADGVYTRGGGPVQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGLAEQTGKRIRLSTKAIVGATSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPSAQRLADCVRRLRTRGAVVVVGTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAAGGVPVPLGHLLAPKFRAMPELMFSADRYHPSAPAYALAADLLFLALRDALTEKLDIPIHETPSRPGTATLEPGHTRHSMMSRLRRPRPARAVPTGG", "function": "Esterase that preferentially hydrolyzes short-chain fatty acids, particularly pNP-acetate (C2) and pNP-butyrate (C4). Has also weak activity with pNP-hexanoate (C6) and pNP-octanoate (C8). It can also hydrolyze short-chain tryglycerides such as triacetin and tributyrin. Important for intracellular survival.", "AFDB_id": "AF-O53423-F1-model_v4" }, { "swissprot_id": "Q0PBX7", "sequence": "MQLVESFLSIQGEGKYNGKLAIFMRFAGCNFNCLGFNVKISKNDKTLIGCDTIRAVFTKDFKESYETLNANELLKRVIKLKKDFDPIVVITGGEPLIHYENPEFIEFIQMLLKNKFEIHFESNGSIEIDFDRYPFYKECIFALSVKLQNSGIKKDKRLNFKALKAFKNYAKDSFYKFVLDANTLDNSFLEINEILKEAPNQIFCMPMGENEQNLKKNAQKIAEFCIKNGYNYSDRIHIRLWNDKEGV", "function": "Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.", "AFDB_id": "AF-Q0PBX7-F1-model_v4" }, { "swissprot_id": "A3LXM4", "sequence": "MDNTTPQQIFSLRSHENSISNIEEVFLWNKHCLISSDTKGWIIIWNINAKRPIRKWQAHDETILTLTLISTNTLLTHGRDASLKIWDISVEHAESSPPELFFLPINTLNFCNVQYFNDFLITPASVDSNNFDIYKITNPEYEFKRVLANFSPFDLYSKNKTEINSPNEQGRNDFGIIMKLVYVEHSNQLFLGFESGQIIGLNINLNPDATLVDKTTEAYSKKTPSKYGGLSSLIDKTSSRTLINKEPRVNLIYSDSSHIPNPITSLVHLKDNILISGSTNKQVIVHHYQMHSIDSSDAHLDVKKVAHSGIQSIVADEKTDTIFIGHWNGVIEGVDYKSNKKKLDSQFELKRDLPHLITTSTNSSGGDTNTIAKEAVKLTSLALSIERENTQVTTTKKKSYKDLVKARSAYIGNDNRLLFAGYEDGAVVAYRL", "function": "Component of the ASTRA complex involved in chromatin remodeling.", "AFDB_id": "AF-A3LXM4-F1-model_v4" }, { "swissprot_id": "P38232", "sequence": "MTLSNCDSLDNLFQDPPEEEESSKFVEAVRTLMNRNDMGYPPAAANGTYCLKKIKSLNAKQWKINKKRMCMLPAVKKKNFDFHEQRSLILNLNLWKFIKFINCSSKNNYNKNNKHVRSSNNTVKNENVLPLQKHKKVDNDQRLENLFWRSWFKARKRRDIMGKPRERHIKFNDNVEQCIITDEHFIQRLPSTRLNSTDEQRPCSKSELDPCIGNAASKRSFYDYNSVYVASDAIITTAAATAIISSNSGDYQRGHDVRDVPRNVLLQAGETDFSSVLRVDSDLKLSNISHHSPVKPSSTSSHSTFIFESETDTDTDTDAETENDIDAYIDTSIPNLLL", "function": "Regulatory subunit, binds to type-1 protein phosphatase. Functions with HEX2/REG1 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly.", "AFDB_id": "AF-P38232-F1-model_v4" }, { "swissprot_id": "O34315", "sequence": "MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLALPRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVATYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGNMVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRVAEKRIKKNQTRIVTVFDMNIH", "function": "Part of the ABC transporter complex TcyJKLMN involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in cystathionine, djenkolate, and S-methylcysteine transport.", "AFDB_id": "AF-O34315-F1-model_v4" }, { "swissprot_id": "Q5KQH7", "sequence": "MESFFVFFTAAALPVVVAAAVIAGLCITAAWLARPRRVAEVFRRQGIDGPPPSSFLAGNLPEMKARVAAAASAAAPTADGEETASAGGGGGGRDFEKDGFDDYCTRIFPYFHKWRKAYGETYLYWLRRRPALYVTDPELIGEIGRCVSLDMGKPKYLQKGQEPLFGGGVLKANGACWARQRKVIAPEFYMARVRAMVQLMVDAAQPLIASWESRIDAAGGAAAAEVVVDGDLRSFSFDVISRACFGSDYSRGREIFLRLRELSGLMSETSVIFSIPSLRHLPTGKNRRIWRLTGEIRSLIMELVRERRCAARAAREHGGKAAPPSPPERDFLGSIIENSGGQPRPDDFVVDNCKNIYFAGHETSAVTATWCLMLLAAHPEWQDRARAEVLEVCGGDGAAAPAAPDFDMVSRMRTVGMVVQETLRLFPPSSFVVRETFRDMQLGRLLAPKGTYLFVPVSTMHHDVAAWGPTARLFDPSRFRDGVAAACKHPQASFMPFGLGARTCLGQNLALVEVKTLVAVVLARFEFTLSPEYRHSPAFRLIIEPEFGLRLRIRRAGGQDATSQVDTSTAPVHSSHN", "function": "Catalyzes the 16alpha,17-epoxidation on non-13-hydroxylated gibberellins (GAs), including GA4, GA9, and GA12. No activity with GA1, GA20, GA53 or ent-kaurenoic acid. Reduces the biological activity of GAs.", "AFDB_id": "AF-Q5KQH7-F1-model_v4" }, { "swissprot_id": "G4NDH1", "sequence": "MQILRIAQLMALLATCASALPTSTGSRVYSRDVDQTQGGFSGSPTTNSPDSVAETGRLEARSGGSSSTETEKERKKRIKAEQNARIRQEEINRKPYQCPYCSDPTVFSHSDALGRHIYTIHRGMPIYNAKDPRKTAIPYNPPGRSTSIFGSEPF", "function": "Probable secreted effector that translocates into the nuclei of host cells to reprogram the expression of targeted genes by binding on effector binding elements in rice.", "AFDB_id": "AF-G4NDH1-F1-model_v4" }, { "swissprot_id": "O29443", "sequence": "MEVEEGRARVKVEGVFYNPRMRFCRDLDMLVFATMDSKEYFDALSASGIRGIRAALEAGKKAVFNDVSPKAVKVIEENLRENGVSGEVINGDAAAVMRQRAFEHIDIDPFGSPAPFMDSACFSAKRYLSVTATDTAALCGSATNSGLKKYGAFAVKTDVYHEVGLRMLIGFVVREATKYEKALFPLISWVREHYYRVHFKIKKSTAMSAKVYEKMGYLAYCSTCLRKKVLGMGEGAERCECGGKFSLIGPIWLGELKQRDFAEKVAEKAEGKLRAFLEKILAEIDAPTAYSLPALAKIHSLTLPPTDVVVEELKKLGYEASRTHYCGFCVKTDADRDVVVKILRSRKII", "function": "Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.", "AFDB_id": "AF-O29443-F1-model_v4" }, { "swissprot_id": "Q7RZP7", "sequence": "MEARALEHERRLAESHGQEALKHAIAAAEIYMRAAEKAANPKDRNRLQRKCSDLIALGERLKANAKSAATSARSPVPESTRTLTIAEKTLLLKSSKLHGNIFPPWEKTPASDEFAASKAADGCFTDHSPFTLSPEQQDIFAGWKRPHEIFMDVPERGVDVFMTATESIDLGQDLATDCSVVASLCAAVRQFGPRTGSLLSSLMYPYDDDVKRPAVSQNGKYIFRMYFNGCWRKVLIDDRLPTSSSERTLYVVDRRNPYLIWPALIEKAYLKIRGGYDFPGSNSGTDLHALTGWIPEQIFLQTDDIELNETWSRIKTAYEQGNALVTLGTGKFSREEERTLGLVREHDYAVLDLRNDGNNRLFLVKNPWRDSLVWTGVGSTATSSTDRSGSPEESMSNTFWMTFEDVLQHFDSLYVNWSPSLFRFRQDHHFTWTIPPKAEELVFTQNPQYSILSHTGSPVWILLNRHWQDSELDILRERKQEHDFHQPLKSLGYMSLSLFASHPPGTRIPLSEGSHHALHQGPFVDSPNTLLRYSPTPGVAQTLVIAQSDLPLPSYSFTLSFFSNSPLTISPASDPLPYNETITGAWTRRTAGGSTVYPSYVTNPQYALTLTRPSPLSLVLSTERADNLPVHIAVLYSNGGQRVTAVVGRDLICSSAEYQRGCTFASTLPSSNTSNVTSSVASNNHGHTSSSLIDPGTYTIVLSTYEPGQTGRYSLRVSAACPFTIEPILSDAAGRLRTPAPSPATFRQGEGRVRARVDVARLTRASVLARSVKTGSTTQKTAMVRVALELGTIEGRKRVLASTASGGGGELAASLSNLSLSERLGGIGGIGGGHIHGGQGTTEGDGYSAKGEFADASLGLRTREVDLDPDVIRVYGGLWLVVEQIGGGGQGHVTEGSDDDGGGGGGGGGGVHVEISSDGVVSIGEWEVADED", "function": "Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.", "AFDB_id": "AF-Q7RZP7-F1-model_v4" }, { "swissprot_id": "P46950", "sequence": "MTKSVGDEESQYIEDPSFAAAAAFTGGRDGVSYSNQRFAEGSGHSSDLAKSLEDYRPPDEKPSSLSSVGEGGANEEEKGGNDGGPLARIQTGLFSPRLRNHRKKILSKFVLNNFFIACVCVSLISIYWGACYGTDRYFFKVKNIVVLQDAPSNTSVQSISAIIPSLLASVPGTWHIYNATSFHRKFGTTNSTEIDRKIVDLIYDERYWLALNVKPNATDTLYNSLISQDANSEFNSSIFFESVFESGRDPSSVKSTILPLMQQLEVRLQKYYVKEYLPSLMSNITSNDRDLNINMENWAIAGQLLFTYNDYRPFADRILMAPLQVGLIYCILLTVLQLSLYGKLHGEMARVLKPKHILIYRLLISWATYFLLSIGFCTVSAIFRIDFTPAFGRGGFVVYWMSTWLVMMAVGGANENVLSLVIAYCPPYLSIWLMTWIILNISASFYPMVLNNEFYRYGYIMPIHNAVDIYKVIFLNLTKRKMGRNYGILVAWVALNTSLMPFCMKFAGKKMQKNAMQAAEAAVAAATQRASRPAEANTDKNNNPPGN", "function": "May function as a N-methyl-N'nitro-N-nitrosoguanidine (MNNG) export permease.", "AFDB_id": "AF-P46950-F1-model_v4" }, { "swissprot_id": "Q6P9F0", "sequence": "MNPPAAFLAGRQNIGSEVEISTIEKQRKELQLLIGELKDRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALESNQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQALTTMIKLKDKDIIEAVNHIADCSGKFKMLEHALRDAKMAETCIVKEKQDYKQKLKALKIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELLFTVEREKRKDELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDSSRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKSSCDECKEKKQQIDTVFGEKSVITLSSIFTKDLVEKHNLPWSLGGKTQIEPENKITLCKIHTKSPKCHGTGVQNEGKQPSETPTLSDEKQWHDVSVYLGLTNCPSSKHPEKLDVECQDQMERSEISCCQKNEACLGESGMCDSKCCHPSNFIIEAPGHMSDVEWMSIFKPSKMQRIVRLKSGCTCSESICGTQHDSPASELIAIQDSHSLGSSKSALREDETESSSNKKNSPTSLLIYKDAPAFNEKASIVLPSQDDFSPTSKLQRLLAESRQMVTDLELSTLLPISHENLTGSATNKSEVPEESAQKNTFVSY", "function": "Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.", "AFDB_id": "AF-Q6P9F0-F1-model_v4" }, { "swissprot_id": "Q8ZXT5", "sequence": "MEVPLVAYLHSCPNCGGPITSDRLASGLPCRECLPDGAKAGSIKQVITALRKRKALQGLAWVEAYLRGYEEFAEFFKRIVGFEMWGAQRLWARRFVRGKSFAIVAPTGSGKTTFILIATLYSAKQGKRALLIFPTSALAHQAYKKLLTFAERGGVSLKALAYHSLLTEREKKEALEALERGDFDVLVTTSAFLPKRFELLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDAVLNTALEVINLTKQLRKAEVAGDLKEVERLDQEMAKLRAKLREEVQRLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYVEASDNVIEQTLALVKRLGPGGIIYVQDRELGEAIVERAREAGLAVEHFFRPRRGVLESFERGELAALVGLASSRSALVRGIDLPHVIRYVIFVGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLAGDARYKADRLIGQLKRLAPYALSVQEALKKASEGAELSSFDRHAVDVVKSAVEFVNSLLQNEEIRKAIETSSEVKLAYIDGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDPKVFHALKRELSLRFDEAEFKHLGEADLDKILADVDRDRKTIRDIMEGRLVPAARGVDLMRTILMVVESPTKARTIANFFGRPSLIISEGIPIYEVSTGDAVLMVTASLGHIYELPTSLNKIDQRQREVLAKWFGDFKHGNYDGENYAVIVKEYGFVPVYNKIWRCRGAVYVDDIDIPPGCKPLDVLEAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVQDIRRVEFHEVTRRAILNALANPRGVNFSLVKAQIVRRVEDRWIGFGLSKILQANFKNPNLSAGRVQTPVLGWIVNTYEESLKNRVYNVELQLNDVDIRLQVPRDVLDVLRKKKRVAIKLVARERRQVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGIAIAREYIVRKFGEGVFKPRSWGEAEEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQLTKSHYQLYDIIFRRFMASQMEPSVVEVAKYNVEIDGHVIQLERTVGVAYMGFQTLYQLTPVEPELPTGTLDVVIKRYRVVRRVLSQADVLALMRQRGIGRPSTYAHILQVLAKRYYVYVTGRTKLMIPTKRGREIFRFLKEAFGKLVSEDRTRLIEQYMDAIEVGKARYEEVIAELYDEFRKEVLPHLAS", "function": "Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.", "AFDB_id": "AF-Q8ZXT5-F1-model_v4" }, { "swissprot_id": "Q9FH28", "sequence": "MDGNKDDASRCLRIAEDAIVSGDKERALKFINMAKRLNPSLSVDELVAACDNLDSVSRNSSVSEKLKTMDGDDDKLETGKMKYTEENVDLVRNIIRNNDYYAILGLEKNCSVDEIRKAYRKLSLKVHPDKNKAPGSEEAFKKVSKAFTCLSDGNSRRQFDQVGIVDEFDHVQRRNRRPRRRYNTRNDFFDDEFDPEEIFRTVFGQQREVFRASHAYRTRQPRNQFREEEINVAGPSCLTIIQILPFFLLLLLAYLPFSEPDYSLHKNQSYQIPKTTQNTEISFYVRSASAFDEKFPLSSSARANLEGNVIKEYKHFLFQSCRIELQKRRWNKKIPTPHCIELQDRGFVDRHIPI", "function": "Plays a continuous role in plant development probably in the structural organization of compartments.", "AFDB_id": "AF-Q9FH28-F1-model_v4" }, { "swissprot_id": "Q164N5", "sequence": "MQVILLERVAKLGQMGEVVDVKPGYARNFLLPQGKALSASKANIEAFEQQKAQLEARNLETRKEAEALAAKLDGQQFIVIRSASDSGALYGSVTTRDAAEAATEAGFTVDRKQVVLSPIKELGLHAVQVVLHPEVDATIHLNVARSVEEAELQASGKSIQELAAEEEAAAEFEIQELFDDIGAAASEDEELAETAGVAPAEPSEEDDSAKA", "function": "Binds to the 23S rRNA.", "AFDB_id": "AF-Q164N5-F1-model_v4" }, { "swissprot_id": "A0PZ39", "sequence": "MTVSIYSLFVIAVALALDAFGVSLSIGLSKNLRYKNKALFCISFGFFQFMLAYIGSYLGVLFNKYILVIPNIIGGIVIFVVGILMLKDGMKKDNKHMNIHKKMYFILGISVSIDAAIVGFTVLNSITSKLLLLESTIFIGIITSILCLIAFLISGYLKRINTISKYANYIGGVILMLFGLEMIFM", "function": "Probably functions as a manganese efflux pump.", "AFDB_id": "AF-A0PZ39-F1-model_v4" }, { "swissprot_id": "Q7LYJ6", "sequence": "MVKLVATLGTSPGGVIESFLYLVKKGENIDEVRVVTTSNAEVKKAWRIVRLMFVCCIQEKFPKVEISEHPLDIEDIYSEDDLRKVREFVEKQLGEGDYLDITGGRKSMSVAAALAAKNKGVKIITSIIPQDDYNKISKKVRELKEIPEIKNRGECRQEMKETYCSLIVQDARSIEFEI", "function": "CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). A nuclease that degrades cyclic oligoadenylates (cOA), second messengers that induce an antiviral state important for defense against invading nucleic acids. Destruction of cOA deactivates the Csx1 ribonuclease, preventing uncontrolled degradation of cellular RNA. Degrades cA4 (a tetraadenylate ring) into a linear diadenylate product with 5'-OH and 2',3'-cyclic phosphate termini. Is 10-fold more active than SSO1393, suggesting this is the major cA4 degradation enzyme. Is highly specific for cA4; it has very poor activity on cA6 and no discernible activity against a number of cyclic dinucletides. There may be 2 active sites per homodimer.", "AFDB_id": "AF-Q7LYJ6-F1-model_v4" }, { "swissprot_id": "Q7Z4M0", "sequence": "MAEAGKVPLSLGLTGGEAAEWPLQRYARCIPSNTRDPPGPCLEAGTAPCPTWKVFDSNEESGYLVLTIVISGHFFIFQGQTLLEGFSLIGSKDWLKIVRRVDCLLFGTTIKDKSRLFRVQFSGESKEQALEHCCSCVQKLAQYITVQVPDGNIQELQLIPGPPRATESQGKDSAKSVPRQPGSHQHSEQQQVCVTAGTGAPDGRTSLTQLAQTLLASEELPHVYEQSAWGAEELGPFLRLCLMDQNFPAFVEEVEKELKKLAGLRN", "function": "Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.", "AFDB_id": "AF-Q7Z4M0-F1-model_v4" }, { "swissprot_id": "Q9AJE4", "sequence": "MKDRAADPVTKFSPSPYETGQFLRISERADVGTPQIDYLLATQRPDGLWGSVGFELVPTLGAVAGLSSRPEYADRAGVTDAVARACEKLWELALGEGGLPKLPDTVASEIIVPSLIDLLSEVLQRHRPAVGGKAGQEQEFPSPPGANAELWRQLSDRIARGQAIPKTAWHTLEAFHPLPKQFAATVTPAADGAVTCSPSSTAAWLSAVGTDAGASTRAYLDEAQSRYGGAIPMGSSMPYFEVLWVLNLVLKYFPDVPIPREIIEEIAAGFSDSGIGGGPGLPPDGDDTAYANLAGDKLGAPTHPEILMKFWAEDHFVSYPGEQTPSETVNAHALEYLNHLRMRRGITEFGAVEDACAEWVISQQTEDGCWYDKWNVSPYYSTAACVEALLDARKQDEPQLDSLRRAREWLLRHQTDSGGWGMAEPSPEETAYAVLALDLFASRGGEGAEECAAAISRAKEFFTDESRENPPLWMGKDLYTPFRIVDVTVMCGRAVVGRY", "function": "Involved in the production of the isoprenoid antibiotic terpentecin. Converts geranylgeranyl diphosphate (GGDP) into terpentedienol diphosphate (TDP) by a protonation-initiated cyclization.", "AFDB_id": "AF-Q9AJE4-F1-model_v4" }, { "swissprot_id": "P15585", "sequence": "MLNIFNYFKNLRVSFHEVFSLFGFFTFMTIIVQLVSGTMLAFSSVPEPMLIPTVRDEEDIEDLYTDDFFWLHERGVDLIFIFSYFHLLRKLYLNVFDLETEASWKSGVFSFLVFQVVVFFGLVLCCTHLSEITLTIAANIFHTFFMFKGKAYWFLFTDKQLNTDTLIRLAYAHYVSAFYLSFLGLLHGIDIHYDWKNEPFYDGLSSEMLWWDEALSNELTNFFVLLVFITLAFFLLFEEPEALSYEIFMWGDIGLSTDVRFYGVAPHWYFRPFMAWLIACPFHKTGIFGLLFFFVTLYYQPNLHGVSDQNSYGKKTLTISSTVLAKKNTATPFSISIDSNLYHQITYFFFIMCCLYTPSFLPYGRFFNQIGGNWGFLFSYFYVFCYLAFTD", "function": "Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.", "AFDB_id": "AF-P15585-F1-model_v4" }, { "swissprot_id": "Q14JF8", "sequence": "MQYTLKQISEHLNAKVINEPSGEVIITGLTYAEQAKENDLTLIDKQEHIKLWQNSKATAAIVSKKISKELAQVNDKPLIVVNNADLAMAKILELFSVPYPEQNGIHEKAIIDPTAKIGKNVSIGPSAYIGKNVEIGDNTIIYANVCIYNDAKVGTNCIIWPSVIIRDRTIIGHFCRLCSNCSIGSDGFGYRPSEDGRTIVRIPHIGNVVIGSFVDIGSNTCINNAKYGSTIIGDYTKIDNLVQIGHNVIIGKGCMICGQAGISGSVTIGDGVIIAGNAGIKDHTNIGSDARIGGKAGVMWDVPAGESHMGYPAYKDSELAKQWIAIRKLPETMKKLKAIAKSLNIDL", "function": "Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.", "AFDB_id": "AF-Q14JF8-F1-model_v4" }, { "swissprot_id": "Q04W49", "sequence": "MNEDPQKKDEPFFKDVEFKASYGEANQIPSQGIPQIAFAGRSNAGKSSLLNAILERKSLAKVSSTPGKTKLLNFFFVNRSIYLVDLPGFGYSANSHKDHEAMMDLLMDYLNLAKDLKCLFLVCDSQRELPEEELELIGTCFERNIKPVLVRTKIDKLNQSDLSKLRKKMKNIHELYPMLETVLVSNKSGKGLPELRKIVDSLITTVGTLVEGNTKKIEGIS", "function": "Necessary for normal cell division and for the maintenance of normal septation.", "AFDB_id": "AF-Q04W49-F1-model_v4" }, { "swissprot_id": "Q5RAC8", "sequence": "MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLESNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVVVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR", "function": "Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation.", "AFDB_id": "AF-Q5RAC8-F1-model_v4" }, { "swissprot_id": "Q8NCK7", "sequence": "MPAPQRKHRRGGFSHRCFPTPQTAMTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYIGLPRALPSCGPASPPATPPPETGELLPAPQAVLLSPGGPGSTLDTTC", "function": "Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.", "AFDB_id": "AF-Q8NCK7-F1-model_v4" }, { "swissprot_id": "A8P353", "sequence": "MSRTATAAGPSTSAPNDGSRTITITNVPTNEGGDDIIPEEDGPVGTLRLRAARTRTGPRVTWDEDVVDNEHAGKKKSKICCIFRPTRDFGESSSSDSDSDSSCDHDHDREEGPSGEGSSSNRPRQGPMQIHDCCDSDDDKNAYERLPSYQRKKIKAKRRAGRFSSLYESQDAHTL", "function": "Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.", "AFDB_id": "AF-A8P353-F1-model_v4" }, { "swissprot_id": "P08650", "sequence": "MGLWGLLCLLIFLDKTWGQEQTYVISAPKIFRVGSSENVVIQAHGYTEAFDATISLKSYPDKKVTYSSGYVNLSPENKFQNSALLTLPPKQFPRDENPVSHVYLEVVSMHFSKSKKIPITYDNGFLFIHTDKPVYTPDQSVKIRVYSLSDDLKPAKRETVLTFVDPEGTEVDIVEENDYTGIISFPDFKIPSNPKYGVWTIKAKYKKDFTTTGTAYFEVKEYVLPRFSVSIEPESNFIGYKNFKNFEITVKARYFYNKMVPDAEVYIFFGLREDIKEDEKQMMHKAMQAATLMDGAAQTCWLAETEVREINYNMFEDRNNNYSYIACTVTESSGGFSEEAEIPGIKYVLSPYTLNLVATPLFLKPGIPFSIKVQVKDSLEQLVGGVPVTLMAQTVNVNQETSDLEPKRSITHSADGVASFVVNLPSEVTSLKFEVKTDAPELPEENQASKEYEAVTYSSLSQSYIYIGWTENYKPMLVGEYLNIIVTPKSPYIDKITHYNYLILSKGKIVQYGTKEKLLYSSYQNINIPVTQDMVPSARLLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPDKDVYSPGQTVSLDMVTEADSWVALSAVDSAVYGVRGKAKRAMQRVFQAFDDKSDLGCGAGGGRDNVDVFHLAGLTFLTNANADDSQYHDDSCKEILRPKRDLQLLHQKVEEQAAKYKHRVPKKCCYDGARENKYETCEQRVARVTIGPHCIRAFNECCTIADKIRKESHHKGMLLGRIQIKALLPVMKAEIRSYFPESWLWEVHRVPKRNQLQVALPDSLTTWEIQGIGISDNGICVADTLKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGTMFCVKMSAVEGICTPGSSAASPQTSRSSRCVRQRIEGSSSHLVTFSLLPLEIGLHSINFSLETSFGKEILVKTLRVVPEGIKRESYAGVTLDPRGVYGIVNRRKEFPYRIPLDLVPKTNVKRILSVKGLLIGEFLSTVLSKEGIDILTHLPKGSAEAELMSIVPVFYVFHYLEAGNHWNIFHPDTLARKQSLQKKIKEGLVSVMSYRNADYSYSMWKGASSSAWLTAFALRVLGQVNKYVKQDQYSICNSLLWLIEKCQLENGSFKENSQYLPIKLQGTLPAEAQENTLYLTAFSVIGIRKAIGICPTEKIYTALAKADSFLLERTLPSKSTFTLAIVAYALSLGDRTHPKFRSIVSALKREALVKGDPPIYRFWRDTLQRPDSSAPNSGTAGMVETTAYALLTSLNLKETSYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLHLDMDINVSYKHKGDFYQYKVTEKNFLGRPVEVPLNDDLIVTTGYSSGLATVYVKTVVHKTSVAEEFCSFYLKIDTQEVEASSYLSYSDSGHKRIIACASYKPSKEESASGSSHAVMDILLPTGIGANQEDLRALVEGVDQLLTDYQIKDSHVILQLNSIPSRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSTSDTNLQRVCEGAACKCVEADCGQLQAELDLAISADTRKETACKPEIAYAYKVRITSATEENIFVKYTATLLDIYKTGEAAAEKDSEITFIKKISCTNANLVKGKQYLIMGKEALQIKHNFSFKYIYPLDSSTWIEYWPTDTTCPSCQAFVANLDEFAEDIFLNGCE", "function": "Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.", "AFDB_id": "AF-P08650-F1-model_v4" }, { "swissprot_id": "Q9HE76", "sequence": "MGFIDDEVKRLGDVIASLEDRVRSLETRDFSGKPVTTAEQLRMVLMGPPGAGKGTQAPKIKEKFNCCHLATGDMLRAQVAKGTALGKQAKKIMNEGGLVSDDIVIGMIKDELENNKECQGGFILDGFPRTVPQAEGLDAMLRERNLPLQHAVELKIDDSLLVARITGRLVHPASGRSYHRIFNPPKDDMKDDITGEPLVQRSDDNAEALRKRLETYHKQTAPVVGYYQNTGIWKAIDASQEPAQVWKSLLAIFEGDKAKASSAGSGIMSKIASAAKSS", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.", "AFDB_id": "AF-Q9HE76-F1-model_v4" }, { "swissprot_id": "P80971", "sequence": "MLRLTAGRVRSLLAGRATAAFSTSSARMASHDLEVAESVDMSKPLYWDRLDTPLPDRPYKEDLTAADKSLKQKEKGPWGQLSKEEKIALYRLMFCQTYSEMKQPSSEWKTVFGGIFIFLGFTGLVVWWQALYVYPPRPRTFDDEWKAKQLKRMLDMRVNPIEGFSAKWDYEKGQWK", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.", "AFDB_id": "AF-P80971-F1-model_v4" }, { "swissprot_id": "Q9HC52", "sequence": "MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.", "AFDB_id": "AF-Q9HC52-F1-model_v4" }, { "swissprot_id": "O95402", "sequence": "MTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.", "AFDB_id": "AF-O95402-F1-model_v4" }, { "swissprot_id": "O95835", "sequence": "MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV", "function": "Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1.", "AFDB_id": "AF-O95835-F1-model_v4" }, { "swissprot_id": "Q04974", "sequence": "MNLMKSSGMFTLTAIGSCRIVSPVKRAQPYFNFQANFKRIYGFTHTSSEALQQIRFILGLIDIPEKVRPFIFRPNVNYSNTDVHSRSDFYIIEISSQKKIMAYGFCLQINYLTRHFYEFFSQTERACMYWSLATQGNRHKLLAYLKDDPCFAGMSEDDRALLSNINVEQMDEHAIEQDMMEIVQLLGRDRVMFMTHVDAVTRAGTVILSRSRLIKNVDTIAARMDIPCVNPTNLMEKWGQKRALEKNGDDLTHYTDMFGDAIVAAIFKGVINNTNHHLDEGRQEKQDQIREITLSITKQLADGDIIAASQQLFAALRNQQQDPVLIQLRSVIFSHLGYYEQAYQDISDVEKIIGTTDSTLRCRLRSLHGLARWREALSTAEMMLSNEIEDEEVLTVAAGSADALQLFDKSYHYWKRVLLLNPETQSGWVNFLSSTQYFNDGNAFSEAFHAGIQSQRLNDTFMETALSLAIKFSDELIFMHALEQLLRHESEFALTVLSTIHDTGLVIRTAFCIKNMSYHQALRTSYKDKIHDVFEAWNNTALSLHSVDDFVSLSTSLAYSYSAFMVYPHSRISRFNNEVKMAWRDKLREMYEREDYENILAGAKIVWPLLKFDPVGTVYCARTLVNLGAWKDACTLAHMTLIRNSNITSLQSIMLRSIRHINNIPFLIDLIANVMSITLSFQNASMNKLFEKECRNVATRALKYVRQKKTEGRLDEALSVLISLKRIEPDVSRLMREYKQIIRLFNESRKDGGSTITSYEHLDYAKKLLVFDSENAYALKYAALNAMHLRDYTQALQYWQRLEKVNGPTEPVTRQISTCITALQKNTSGKS", "function": "May be required for maturation of the Vi polysaccharide.", "AFDB_id": "AF-Q04974-F1-model_v4" }, { "swissprot_id": "Q9HBJ0", "sequence": "MKVFKFIGLMILLTSAFSAGSGQSPMTVLCSIDWFMVTVHPFMLNNDVCVHFHELHLGLGCPPNHVQPHAYQFTYRVTECGIRAKAVSQDMVIYSTEIHYSSKGTPSKFVIPVSCAAPQKSPWLTKPCSMRVASKSRATAQKDEKCYEVFSLSQSSQRPNCDCPPCVFSEEEHTQVPCHQAGAQEAQPLQPSHFLDISEDWSLHTDDMIGSM", "function": "May play a role in placental development.", "AFDB_id": "AF-Q9HBJ0-F1-model_v4" }, { "swissprot_id": "P53130", "sequence": "MFYLSDIEEEASAGAEPTYNFWEVLLFSNTQENLVTVVGELHTLTDRVVHYKIEPESREVTATTLPSLLALLLEKRNQARRLYRDVLSMKMSELDWDIDDLFTQLQEELTRTDDTLSMYPRRRFYH", "function": "Gamma subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth.", "AFDB_id": "AF-P53130-F1-model_v4" }, { "swissprot_id": "Q12216", "sequence": "MASVMSNNNNNNNNNNASYMFTNPLSNTGGGLINEIKDAINEMEQLKVLELKQICKSLDLSITGKKAVLQDRIKQFLRKSCDIGHIDPWRPKAIKILIAKVRINSSLPKYSTLWETLKTGAFKHPVASGQLPVTALQSTALPPYSQQQALAYSFTSPFYKPIVQIPDANKKLKQSAGRGCTKMKFKVSKSNHDLLKSNKSYKLYLFSGFSIPFIYETVGHEAIDFPYPCELVFNGTKLEDNVKGLKKQNGTGNPANLTPYLKVPTEMNHLDLHYLNIDKEYSISCFIVEVFSPEALLGKILKRPKIIKQATTAYIKRTLNEQDDDDIITTSTVLSLQCPISCTRMKYPAKTDQCKHIQCFDALWFLHSQSQVPTWQCPICQHPIKFDQLKISEFVDNIIQNCNEDVEQVEISVDGSWKPIHNSSAVITDTVNQNHSVKNENQGTVKQEQDYDSRNAFDTNLRNGSNHNEPEIISLDSSDDEAFIPASKSFPTHVNPRNDQLRADIFPSESEGSSDYNPNHTSTPKGSPTMDQDNYQDAFQMRSFLNQGATTNINDTPTNNSSINSFVTATNGDSRIFYNRGPSTPLLPAVLQNLTNQTEAQRNPYGPNYNTTAQDRNLLGIEGDLPPIPPVDPNSEAETELPTRTTSAAHLPPYIHVSTSGHGDDGKIRKRRHSNVSIYIPKNPYATLMKRRPQANHAIMNKTLAQTNDFNTSAQDNSEVVDLTSD", "function": "May act as an E3 ligase mediating SUMO/Smt3 attachment to septins. May be involved in chromosome maintenance.", "AFDB_id": "AF-Q12216-F1-model_v4" }, { "swissprot_id": "Q8K245", "sequence": "MSSCASLGGPVPLPPPGPSAALTSGAPARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCDNEKIFKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKEEAFQLLIEWKVYLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPCEHKGHPNAQKNLLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQRLGKEIEEKLRLTSTSNELKKESECLRLKILVLRNELERQKKALGREVAFLHKQQMALQDKGSAFSTEHGKLQLQKDSLSELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNENKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHISNAIPVPKRQSSTFGGADGGFSAGIPSPDKVHRKRASSENERLQYKTPPPSYNSALTQPGVAMPTSGDSERKVAPLSSSLDTSLDFSKENKKAGVDLGSSVSGDHGNSDSGQEQGEALPGHLAAVNGTALPSEQAGPAGTLLPGSCHPAPSAELCCAVEQAEEIIGLEATGFTSGDQLEALSCIPVDSAVAVECDEQVLGEFEEFSRRIYALSENVSSFRRPRRSSDK", "function": "Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation.", "AFDB_id": "AF-Q8K245-F1-model_v4" }, { "swissprot_id": "P00721", "sequence": "TVQGFDISSYQPSVNFAGAYSAGARFVIIKATEGTSYTNPSFSSQYNGATTATGNYFIRGGYHFAHPGETTGAAQADYFIAHGGGWSGDGITLPGMLDLESEGSNPACWGLSAASMVAWIKAFSDRYHAVTGRYPMLYTNPSWWSSCTGNSNAFVNTNPLVLANRYASAPGTIPGGWPYQTIWQNSDAYAYGGSNNFINGSIDNLKKLATG", "function": "This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.", "AFDB_id": "AF-P00721-F1-model_v4" }, { "swissprot_id": "A7I1I1", "sequence": "MQKLKFYLNHEASGGILIIIATILALICQNMILTDFYNHFLRIESGIIFGEYKIIKPIILWVNDGLMAVFFFFIGLEVKKEILIGELSSPKKVALPVIGGIGGVVIPALLFLAVNFGDEFARRGWAITTVSDTAFAVGILLLLGSKVPSSLKIFLLLLAIIDDICAVVIVAFFYTSELSNFAIFMAGIGILIFLVLNILKVNKISFFIAAGSFLWVSFLESGIHSTIAGIVASFFIPLKPIKGYCMLDDVKHKLEGFITYLIMPIFAFVNAGIALNSDAFSNLLHPVSIGIILGLLIGKPFGVFIFSYVAIKFKLCSLPTGSNFKQFLGLGFLTGIGASMSLFIDSIAFMDSDQFAYADKLAILIASFLAAFIGWRILKTSGNKNENFETIKEAETTNSTAEKIEDIDENKN", "function": "Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.", "AFDB_id": "AF-A7I1I1-F1-model_v4" }, { "swissprot_id": "B3LT42", "sequence": "MKSSKQLVQDAKDYRFNPAIPLRIYLKTCIGILEKAQCAFQANDLSLSFIYYFRYVDLLTNKLSRHPELLRMDASSSSSSSYIHKREYLQLIKLEVPAVCKIIESLRTQIDSQYSKLQTSLANNIAKPNINANTTPVQVEQQPLPKKSFDEYSFNQSISFFQKISNAQLNTGASSQSQATARDEAYRLNYPELPRLTFST", "function": "Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.", "AFDB_id": "AF-B3LT42-F1-model_v4" }, { "swissprot_id": "O06926", "sequence": "MAKWTELQDKSFLEATARERAVGIVDEGTFTEFCGPFDKIYSPHLPLMGEAIEYDDGLVAGVGKIGKKPIFVISQEGRFIGGSIGEVSGAKMVKTIQLASDLYEEMVSEKPDLPEEMRPAVVISFETGGVRLHEANAGLLAHAEVMDQIQNCRGRVPIISLIGSRVGCFGGMGFVAAATDVIIMSQFGRLGLTGPEVIEQEMGKDEFDASDRALVYRTTGGKHKYIIGDCNYLAADSIRSFRETTTAVLQKPMEEIETFRRIGSMEKIKEQIELVKLSVSLKPKDSMDVWAHAGNENPESLINMTLDEFLAQAKRLKA", "function": "Gamma subunit of the biotin-dependent malonate decarboxylase multienzyme complex (EC 7.2.4.4). The two subunits MADC and MADD are required for the transfer of the malonate carboxy group from the acyl-carrier protein (ACP) to the prosthetic group of the biotin carrier MADF. Required for the regeneration of ACP.", "AFDB_id": "AF-O06926-F1-model_v4" }, { "swissprot_id": "Q83V26", "sequence": "MMFTFGKPLNFQRWLDDHSDLLRPPVGNQQVWQDSDFIVTVVGGPNFRTDFHDDPMEEFFYQFKGNAYLNIMDRGQMDRVELKEGDIFLLPPHLRHSPQRPEAGSRCLVIERQRPKGMLDGFEWYCLSCNGLVYRVDVQLNSIVTDLPPLFDIFYGNVGLRKCPQCGQVHPGKAAIEAVARGDQP", "function": "Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.", "AFDB_id": "AF-Q83V26-F1-model_v4" }, { "swissprot_id": "O34889", "sequence": "MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPTEENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCTNLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV", "function": "Required for the maturation of SdpC to SDP. Not required for SdpC signal peptide cleavage, secretion from the cell or disulfide bond formation.", "AFDB_id": "AF-O34889-F1-model_v4" }, { "swissprot_id": "Q7Y201", "sequence": "MAFQDFDKIQERVNANRKRKFRKRIIVGTVSLLVVVAAIVGGAFAYVAYEKRNEQQQQQQQAKNHNKSGSGNNVVKDSDKKSPSPPTPSQKAPVSAAQSVKPGQGDKIIQTLCSSTLYMQICEKTLKNRTDKGFALDNPTTFLKSAIEAVNEDLDLVLEKVLSLKTENQDDKDAIEQCKLLVEDAKEETVASLNKINVTEVNSFEKVVPDLESWLSAVMSYQETCLDGFEEGNLKSEVKTSVNSSQVLTSNSLALIKTFTENLSPVMKVVERHLLDDIPSWVSNDDRRMLRAVDVKALKPNATVAKDGSGDFTTINDALRAMPEKYEGRYIIYVKQGIYDEYVTVDKKKANLTMVGDGSQKTIVTGNKSHAKKIRTFLTATFVAQGEGFMAQSMGFRNTAGPEGHQAVAIRVQSDRSIFLNCRFEGYQDTLYAYTHRQYYRSCVIVGTIDFIFGDAAAIFQNCNIFIRKGLPGQKNTVTAQGRVDKFQTTGFVVHNCKIAANEDLKPVKEEYKSYLGRPWKNYSRTIIMESKIENVIDPVGWLRWQETDFAIDTLYYAEYNNKGSSGDTTSRVKWPGFKVINKEEALNYTVGPFLQGDWISASGSPVKLGLYDA", "function": "Acts in the modification of cell walls via demethylesterification of cell wall pectin.", "AFDB_id": "AF-Q7Y201-F1-model_v4" }, { "swissprot_id": "P20629", "sequence": "MLHFPDPFATGPGPVIPAEALGFILAQGLRECAAGLGPLTARLGLSGADLAALRDRFAPGLELPDLDLPRPEAGPDQQAIETLILWRAGVATPEARWLAAILARRSMETRHLWEDLGLPSRPWLSGMIAHFLPGLAAANARNMRWKKFFYRQICSDAAFSLCLSPSCDDCDERAACFAPD", "function": "Probably involved in molybdenum processing.", "AFDB_id": "AF-P20629-F1-model_v4" }, { "swissprot_id": "O87236", "sequence": "MNKNEIETQPVTWLEEVSDQNFDEDVFGACSTNTFSLSDYWGNNGAWCTLTHECMAWCK", "function": "Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. When present individually lacticin 3147 A1 exhibits strong activity towards L.lactis strain AM2, weak activity towards L.lactis strain HP and no activity towards L.lactis strain IFPL359, but when combined with lacticin 3147 A2 it displays strong activity towards all three strains.", "AFDB_id": "AF-O87236-F1-model_v4" }, { "swissprot_id": "Q6NKU9", "sequence": "MAAENSSNAINVDTSLDSDSKPNRDANDMTDHDSSSKALVIPAPAVCLVRFAGDAASGAFMGSVFGYGSGLFKKKGFKGSFVDAGQSAKTFAVLSGVHSLVVCLLKQIRGKDDAINVGVAGCCTGLALSFPGAPQAMLQSCLTFGAFSFILEGLNKRQTALAHSVSFRQQTRSPQHDLPLLSLAIPIHDEIKGAFSSFCNSLTKPKKLKFPHAR", "function": "Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.", "AFDB_id": "AF-Q6NKU9-F1-model_v4" }, { "swissprot_id": "Q7L5L3", "sequence": "MSLLLYYALPALGSYAMLSIFFLRRPHLLHTPRAPTFRIRLGAHRGGSGELLENTMEAMENSMAQRSDLLELDCQLTRDRVVVVSHDENLCRQSGLNRDVGSLDFEDLPLYKEKLEVYFSPGHFAHGSDRRMVRLEDLFQRFPRTPMSVEIKGKNEELIREIAGLVRRYDRNEITIWASEKSSVMKKCKAANPEMPLSFTISRGFWVLLSYYLGLLPFIPIPEKFFFCFLPNIINRTYFPFSCSCLNQLLAVVSKWLIMRKSLIRHLEERGVQVVFWCLNEESDFEAAFSVGATGVITDYPTALRHYLDNHGPAARTS", "function": "Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.", "AFDB_id": "AF-Q7L5L3-F1-model_v4" }, { "swissprot_id": "P42312", "sequence": "MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITWFMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVTFFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVLSNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPEDEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHGLTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHTVAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIVGLFVW", "function": "Involved in the uptake of the purine ribonucleosides inosine and guanosine.", "AFDB_id": "AF-P42312-F1-model_v4" }, { "swissprot_id": "P47016", "sequence": "MTSKLKRVAVAQLCSSADLTKNLKVVKELISEAIQKKADVVFLPEASDYLSQNPLHSRYLAQKSPKFIRQLQSSITDLVRDNSRNIDVSIGVHLPPSEQDLLEGNDRVRNVLLYIDHEGKILQEYQKLHLFDVDVPNGPILKESKSVQPGKAIPDIIESPLGKLGSAICYDIRFPEFSLKLRSMGAEILCFPSAFTIKTGEAHWELLGRARAVDTQCYVLMPGQVGMHDLSDPEWEKQSHMSALEKSSRRESWGHSMVIDPWGKIIAHADPSTVGPQLILADLDRELLQEIRNKMPLWNQRRDDLFH", "function": "Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro.", "AFDB_id": "AF-P47016-F1-model_v4" }, { "swissprot_id": "Q9SBL1", "sequence": "MGSNAPPPPTPHVVLVPFPGQGHVAPLMQLARLLHARGARVTFVYTQYNYRRLLRAKGEAAVRPPATSSARFRIEVIDDGLSLSVPQNDVGGLVDSLRKNCLHPFRALLRRLGQEVEGQDAPPVTCVVGDVVMTFAAAAAREAGIPEVQFFTASACGLLGYLHYGELVERGLVPFRDASLLADDDYLDTPLEWVPGMSHMRLRDMPTFCRTTDPDDVMVSATLQQMESAAGSKALILNTLYELEKDVVDALAAFFPPIYTVGPLAEVIASSDSASAGLAAMDISIWQEDTRCLSWLDGKPAGSVVYVNFGSMAVMTAAQAREFALGLASCGSPFLWVKRPDVVEGEEVLLPEALLDEVARGRGLVVPWCPQAAVLKHAAVGLFVSHCGWNSLLEATAAGQPVLAWPCHGEQTTNCRQLCEVWGNGAQLPREVESGAVARLVREMMVGDLGKEKRAKAAEWKAAAEAAARKGGASWRNVERVVNDLLLVGGKQ", "function": "Involved in the biosynthesis of the cyanogenic glucoside dhurrin. Prevents the dissociation and release of toxic hydrogen cyanide. Mandelonitrile, p-hydroxymandelonitrile, benzyl alcohol, benzoic acid and geraniol, but not hydroquinone(1,4-benzenediol), alpha-terpinol, linalool or farnesol are utilized as acceptor substrates. UDP-glucose, but not UDP-xylose or UDP-glucuronic acid can be used as sugar donor.", "AFDB_id": "AF-Q9SBL1-F1-model_v4" }, { "swissprot_id": "Q9BGI1", "sequence": "MRLGWLRVLGCRPGSVVSRATIVEGASTTAAGTRGCLEGILEWTFGGVRGFRSAAVAMAPIKVGDAIPSVEVFEKEPGNKVNLAELFKGKKGVLFGLPGAFTPGCSKTHLPGFVEQADALKAKGIQVVACLTVNDVFVTEEWARAHKAEGKVRLLADPSGTFGKETDLLLDDSLLFLFGNHRLKRFSMVIEDGIVKSLNVEPDGTGLTCSLAPNILSQL", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.", "AFDB_id": "AF-Q9BGI1-F1-model_v4" }, { "swissprot_id": "P64525", "sequence": "MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGFSACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK", "function": "Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB. Toxic effects are neutralized by cognate antitoxin CbeA (A0A0H2V8S8), although there is no direct interaction detected between the 2 proteins.", "AFDB_id": "AF-P64525-F1-model_v4" }, { "swissprot_id": "Q12172", "sequence": "MKRRSDALLGSFQATNVTPPSDNSNSTAGGANGSNSGTPTSTSGKKRNKLIKSCGFCRRRKLRCDQQKPMCSTCISRNLTTCQYAEEFNKNIEKKATYGPYPNADLLKKVEELENKIRILEAEKNTNSSASSMYTSPNFPPLGTSVGRGSTETSSPLPDGVINPYADRYYLQSKHSGRSTLYGPTSMRTQIANSNWGFIEKYKQLWAKVKVERNKWKQNNQKTMCRELGLLDESDWQPDPLIKQICRFLPSYNKALSILDDFFNDGACNEINVILDKAKVRRDFLDYFMPEKEVKAEGDRSIVYILSNPKKNYYKAAVILLILCLKYFHTDVPTPIEKFFTLLKGASTAKVFYIERAQMLILFYYHRETYSFGGDGSDLVNINECLVTTVTTIGLHLNIRETFKEHEVFMGSIESLENVWLMAIFIDYNISCNVGRPLLINKFYLDENQDHCILNSKSKTYEGKLKRYLKLTRPMLLTLYDRDKFPDLKAYSKRIINFVEEELGPLGHYTGENISEEVPLRESRILSMAVGLLLSFYALIHSVLKVRNIESKNNTFQLVLINFSIIVNTTIRCYRIDKALYPEKFEASNPHLPPHMALSMSLTAGLFSKTLVFFCSLIYFKLTLFENGLCLSNDMEVGWSDLTKLTVPLDKDLSLGTAMSLYSSIFDRLFTVGNKELIRTMHRSSQFVIELAIERTYRTILGNVIEFRKLTEETWLAQIKQELDPQSDNPSSEAKIVSDRQRDLSLAVPTPTPSIIPMLPSPGETKNHAKSQSEIIQMLTDEFWANYNSGWEELINQSEFSTLFDDYKDN", "function": "Transcription factor involved in the regulation of multidrug resistance genes. Acts in concert with YRR1.", "AFDB_id": "AF-Q12172-F1-model_v4" }, { "swissprot_id": "O13821", "sequence": "MSRWWNSNSQFASDIEKATSETLPAGSEEISLYLEISDQIRSKSVDPKFAMRILKSRIDHSNPNVQIMALKLTDTCVKNGGSGFLLEIASREFMDNLVSILRSPAGIDEDVKMVILRYIQSWALAVPDTNSPLSYIIHVYQNLKDGDYEFPEPSQNITSKFLDTETPPDWTDSEVCLRCRTPFTFTNRKHHCRNCGGVFCNQCSSKTLSLPHLGINQPVRVCDSCYSLRTKPKGSKSRARNERKFHAKTRKTPSKPVTNNEDEDIKRAIELSLKEMPQSREPPSYERPSEANVVISQDQHLTEDEDEELKRAIAISLEEAQKSSQKDDNVTAPNNMNISYPSVPAHTVSTDIRSSPFSGRPSDNPSTLISTADADNITLYATLVQKLKKLPPGSIFTEYQLQELHENMGVMRTRMMRSLGETMSKYNGLIQALQKLQTCMRLNDALIEQRLSSTYAHHYIDSSMDSNRSIEPEPDVISTVRNSSTIPQASSSSVPKIVVDSSPVTENPPSHSDVMGQKDTISSYYSTDTDVSANVMGNRHDEVVFSDTASGEKNTKLNIDESTNYYNTDSIDKVGEPFDEISSGYDDLMNGNDKQGNDIPEVQEASLIEL", "function": "Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.", "AFDB_id": "AF-O13821-F1-model_v4" }, { "swissprot_id": "H2KYS3", "sequence": "MHLENRVLSSVLDYASKFYKRMSSLVFFSANSIQVQMNISQSSWIKCRDWMAFALSHHIIMGIYLLILRNFLPQVVPDFEWQHYFMRVFIVHIIYIIISYFIRITRYPPGPPPMAVFGNSPFVNILTPEQTFLEYREIYGPIFTLHLSQPTIILAEYKTIQEALVKNGQQTSGRSSAESFVLFTGDRLNGDGVILAMRQKWKDMRHEISRFMNKWYGAPMDELVLHHTRCLEQELAKIAETKSLIDLRDPLAGAIANVIQQITIGRNYMYQDQEFQTQLRDINAVVKEIMTAEVFFVNCYPWLRYLPEGILRKWTNYKRSGFRLQQWFRTILEEHHVNRHQGDFMSHMIDLQESKQEQFRDLSIILTCGDMWTGGMETTVTTLRWGIIYLLNNPEVQAKCQMEILDVFGNDIPDMGKMNQTPYVRATLSEIQRLANVLPWAIPHKTIEECNIGGYDIPVNTEIIPALGAVLFDPNVFESPKQFKPERFLDEEGKYRVMEEFRPFGLGPRVCLGERIARTELYLIFASLLQNFRFYLNRGDPIPVAERVIGGITAPPKPYATRVEYLGNRLIN", "function": "Converts the 3-keto steroids 4-cholesten-3-one and lathosterone into the carboxylic metabolites 3-keto-4-cholestenate (Delta(4)-dafachronic acid, Delta(4)-DA) and 3-keto-7,(5a)-cholestenate (Delta(7)-dafachronic acid, Delta(7)-DA) respectively, by catalyzing successive oxidations at C-26. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) DAF-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in thermotolerance.", "AFDB_id": "AF-H2KYS3-F1-model_v4" }, { "swissprot_id": "Q03475", "sequence": "MSSIDPATFAAQFAQIEIQPFKQRYQLQTNTYQSQLSALGKVESAMREFRTALNEMNSSTNSIIKNSTSISQEGYFTANADAKALSGSYQIFVEQVATSHQVSTGMPADLDATTEIPKTGNLEFTINGKTMTIDLSTVDTDGDGVTTVSDLTKAINNNSDNPGVNATLVRSNGQTHFMLSSTETGVANQINVSATGTGQAWFEDAFTNLSQISAPQDAVIWLGAEKTGLKLTNSSNTFEGVIDGVDITVTKAQTSGETAIGLGIGADDEATKEQLNKFVDAYNTLISTIDEHTQIGSEDKKRGVLASDPTMRSIESQLSSLVRGEHGGMRLSEIGVTLDRHGKLKVDQEKFAEAQKNNSAGLEAMFNGDGALLDSMDAMAEPFLKFSSGAFKSRKEALQANLDRLSDKQTTLERKYDMSYKRYLKQFTQMNTLMTQMNQTMSMFG", "function": "Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential for swarming motility.", "AFDB_id": "AF-Q03475-F1-model_v4" }, { "swissprot_id": "O74349", "sequence": "MKKKSTDLYGRKNPGMQSMSGSFSSLQIALDESSSNFSTIYEPPDLSGLDAEMIVIVKNLQKRDIVTKCRALQDLIQWNDPSQFDNEQFLNALAVLFPRLSIEVERHVRLKIFVFMSVLSSALQKKLAPWLKFYITPWVMGFFDSDRAVSVSAKDSFKNLLSEEKWPHVWLKFGSTIAPIVTDVFLHEDKESLTDLRFFSNEEAESKVTRVKSSCLLTLSFLFKQTADLENLETDKKIDKQTFKSSLYENLSTLFKSDEFWSLVSSPQDGVTVSLSDLLLIILKYDKPFVTQYKEKYFKRVSRMISRLTSLTCVPMLRLLSNMISNFPNEVHQFANDSKRPLSKLFSNLITKRISLPNSGFYTSLLNLFKSIGAMQLVPSIESVDELCDAFLETANQEQRFLSTEVYDCLLNFLSFVYTDSSDPQIKDHVRDRLRTIFTRYFKGEFVLRCSTSDFDHCLQSVFDKNSDFASLWNEVLFGFFNDESMDIETIPFDSLSRNLSLTVQTVLYLKNRNFQTGNEVMSILGPCLSFLMKLSTHKNERIACLSASQLITVCHIFSDTTLIKPVKELFQKYLVNDLPSSILKLGPQSPAFTLLRDILLLLKDYADLSEPWENVANQFTVSFDELENIRVLNSLPSLFADGKLRGKISLVKTLVEYYDTAVFAIMQNPGNDWDMIRACIGSKEILVPEETIKNILFTTLEYFLTNDWVDNHLIILCASLHSLKAHLPTIFDENKSLYSLLPVILFSKPEDDGHVAAHFESIFSLLKEKALEDSGFSLKLCSEVQEWSLNKVLNGSINEKLAADKCVLVFNSFGKLPSNFFTFPASFWDAKISSCIPFFSNKLFIDQDFILGFLDLVASEPINVDMTDVGTQFVHIFHASLYTLYYVETTGCDGDALFNLTFAYLLIRIYLQNGIQSIIDVPIRDAGIFVESFECYFKGEVVKFMRDKDALTVLNELLIDDIDGKMPVLFKRFKNLSSAENTTSFSIFAAQGLTDFLIVVSNLLEMDEKHVDVVLGKLGLSSSKSPIFVSSILEGLKPLEVDSEIIQRIRFKAVNDLTGKLHSANEVSKSLLILNAATTQQITEKPLLPITRCRLFLENITNWCSESGIKSLELLPVCCFLRFMYYFLPTVFSLSGSYWNSIFDYIKYAMKMSVVDAPIVKSFELFALRLYNALSKNYEMNSDIKDCIVESNESMNYLLLKRFLFTHESTLRNSVTARMCNQYLVKLLENCPGKVVRSFQYQEFFPSLCNSNDLQMESVCMKFLREKLSHELKELTVYYMVESDYEPDVSLCPELLSLAIDFPGDPFVMVSKMEKYEHALRVYLLVWDLIFYHFEETTYNIKLSIINQLHAMDLLRPLLNTLVEILNLSYDRPINVDKYPKIDYNLMDYSSATDRIRCLAIHIYYQCLRHLSSSVRSYWSEVKNRAFTSTVESFTGYNVSPLLISASLDDVERSIESEDFQSVGDVNVKVNRNTREISFIYNVDEHKLEMAIKIPSVYPLQNVQVEGIERVGVNERQWRSWILASQSILSSQNGSITDALLVLKKNISMHFEGVEECAICYSVLSVERTLPNKRCGTCRHKFHASCLYKWFKSSNSSRCPLCRSSFTFV", "function": "E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to cdc48 recruitment for extraction and degradation of the incomplete translation product.", "AFDB_id": "AF-O74349-F1-model_v4" }, { "swissprot_id": "A0A3S7WQS5", "sequence": "MDDRSLKLAEDFVSARYIEAGRESLRATARIMRSILAQRCCPDEGLTDAAIELILRQLSLMDTNNLAHHVGGGEREGRVVSALVRMRHFHLTHGIGRSGDLFSEQPKAAGSSLLYKITNVLMLDLIRQAGAPSTAAAVVVPMATGMTLALVLRCVAKTHMKELMKEAEAVQLQRTVTKDSTSATSAAPVQEPPMSEADRDRHDRTSLPVPATPRYVIWPRIDQKTALKCIDAAGLVPVPVQLRPAVPLARSAAPCVSTNRDSLDRGQDSIGSPSTPTSSSSLFLECHVDDVAAAVNAVGGPSQVVCVLSTTSCFAPRLPDNTVAIAQYCKKAGIPYVVNNAYGVQSRRIMTRLDAAQRLGRVDFVVQSGDKNFLVPVGGSIICSGDKERCKAVAALYAGRASMSPIVDLFITALSLGRRGMQTLWSDRYKCRARLIRQLRVFARERREVLLVDDSDDDKADEDTVGGSQRTSNAVVPRNDISVAVTMRAYGLPAAEASSSGAQLGSEQAGRVTNWAAARALGAQLFRSAVTGPRVITPAPSTPTTIAGCTFRNYGMHQDREPPCPLLVIACGIGMSESEVDALMARLRDLWPVPA", "function": "Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.", "AFDB_id": "AF-A0A3S7WQS5-F1-model_v4" }, { "swissprot_id": "P35184", "sequence": "MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMFDNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGDEGVSLVFEVPN", "function": "May be involved in the late step of 60S ribosomal subunit assembly or modification in the cytoplasm.", "AFDB_id": "AF-P35184-F1-model_v4" }, { "swissprot_id": "C1F9D0", "sequence": "MIQGMTDTYPLLRILPEIIFTITGVVVMVLEPLFPKHASRKPLGWLTVLGALLALAASFYQYGLPIGTAYFGVVQTDAFSVFFHILISGIVLVSALVTIDAIKPDTENTGELFALMAFGAVGMLLMTCAAELLLVFIGLEISSIATYILAGFRRRSAKGPESAIKYFLLGSFATAFFLYGIALTYGATGTTNIPDIAAALLTSHALPLAVVGLSFILIGLAFKVSAAPFHLWTPDAYEGAPSPVVGLMSTAPKAAAFAVLLRIAYEAFPVFHFHWVPLLWIIAALSMTIGNLGALRQRNVKRMLAYSSIAHAGYLLVAFTALSPDGIAAASFYAVTYAAMNVGIFAVISHVGGYDDRLTLVEDYKGLAYRSPLLGGVMAFFLLSLIGIPFTGGFFGKFYVFSAAIHSGMIWLAIIGLINSGIAVFYYLRLLTATYSKPAESALVLTTGRPSFALLLALFLTVATTLLLGIFPGSVLARAQEGAYTFYRAPLVILGTHAGVFADPATAKSITSPTP", "function": "NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-C1F9D0-F1-model_v4" }, { "swissprot_id": "O85226", "sequence": "MRQIDRNFDIQPLQHADMTISLNGQPVTAALGETVLSVIQATGLRQVARNDHGQLVGAYCGMGVCHCCLVQIDGRHKRRACQTLVKPGMQVQTLSNRITETEPTL", "function": "A three-component membrane-bound flavoenzyme that catalyzes the formation of hydrogen cyanide, a secondary metabolite, by transfer of electrons to a cyanide-resistant branch of the aerobic respiratory chain. Contributes to suppression of black root rot of tobacco.", "AFDB_id": "AF-O85226-F1-model_v4" }, { "swissprot_id": "P0DMT8", "sequence": "MRPAVSIALALVALLVLADSARSEPGEPTLMQKLEQFKENVKVFADNIGEKTKAALQELHDSEFSTKTRNWFSEHFKKVKEKLKDTFA", "function": "Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.", "AFDB_id": "AF-P0DMT8-F1-model_v4" }, { "swissprot_id": "Q9X807", "sequence": "MSSQDIPEENLPAEQDRPHGAAARPADETNPFADPGLPPHEPRVQDVDERAAKRSERTVALLFTLSMLATIAFIAAFVAIDVDKSVYIFPLGHISALNFALGMTLGVALFAIGAGAVHWARTLMSDEEVADERHPIEASPEVRAKVHADFKQGAKESVIGRRKLIRNTMLGALTLVPLSGVVLLRDLGPLPGTKLRHTLWSKGKLLVNMNTNEPLRPSDVAVGSLTFAMPEGLEEHDEDFQNEIAKAALMIIRLEPDSIKDKRELEWSHEGIVAYSKICTHVGCPISLYEQQTHHALCPCHQSTFDLADGARVIFGPAGHALPQLRIGVNDEGYLEALGDFEEPVGPAYWERG", "function": "Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.", "AFDB_id": "AF-Q9X807-F1-model_v4" }, { "swissprot_id": "P80036", "sequence": "MQFGIVAAIADGGRTARAGGSVRPPRRPPASHTAWGLPRGRPTGQPHATPTKSGPTSIAYVEVNNDQLANVGRYQLANGANAFDVAIIFAANINWNGSKAVLYNNENVQATLDDAATQIRPLQAKGIKVSLSILGNHQGAGIANFPTQAAAEDFAAQVSATVSKYGLDGVDLDDEYSDYGTNGTPQPNQQSIGWLISALRADVPGKLISFYDIGPASSALSSSSSTIGSKLDYAWNPYYGTYSAPSIPGLDKSRLSAAAVDVQNTPQSTAVSLAQRTKADGYGVFMTYNLPDGDVSPYVSSMTKVLYGQAATYH", "function": "Cleaves asparagine-linked oligomannose and hybrid, but not complex, oligosaccharides from glycoproteins.", "AFDB_id": "AF-P80036-F1-model_v4" }, { "swissprot_id": "Q9AWL7", "sequence": "MSASNEKWIDGLQFSSLFWPPPQDSQQKQAQILAYVEYFGQFTADSEQFPEDIAQLIQSCYPSKEKRLVDEVLATFVLHHPEHGHAVVHPILSRIIDGTLSYDRNGFPFMSFISLFSHTSEKEYSEQWALACGEILRVLTHYNRPIFKVDHQHSEAECSSTSDQASSCESMEKRANGSPRNEPDRKPLRPLSPWITDILLAAPLGIRSDYFRWCGGVMGKYAAGGELKPPTTAYSRGSGKHPQLMPSTPRWAVANGAGVILSVCDEEVARYETANLTAAAVPALLLPPPTTPLDEHLVAGLPPLEPYARLFHRYYAIATPSATQRLLFGLLEAPPSWAPDALDAAVQLVELLRAAEDYDSGMRLPKNWMHLHFLRAIGTAMSMRAGIAADTSAALLFRILSQPTLLFPPLRHAEGVELHHEPLGGYVSSYKRQLEVPASEATIDATAQGIASMLCAHGPDVEWRICTIWEAAYGLLPLSSSAVDLPEIVVAAPLQPPTLSWSLYLPLLKVFEYLPRGSPSEACLMRIFVATVEAILRRTFPSETSEQSRKPRSQSKNLAVAELRTMIHSLFVESCASMDLASRLLFVVLTVCVSHQALPGGSKRPTGSDNHSSEEVTNDSRLTNGRNRCKKRQGPVATFDSYVLAAVCALSCELQLFPFISKNGNHSNLKDSIKIVIPGKTTGISNELHNSISSAILHTRRILGILEALFSLKPSSVGTSWSYSSNEIVAAAMVAAHVSELFRRSRPCLNALSALKQCKWDAEISTRASSLYHLIDLHGKTVTSIVNKAEPLEAHLTLTPVKKDEPPIEEKNINSSDGGALEKKDASRSHRKNGFARPLLKCAEDVILNGDVASTSGKAIASLQVEASDLANFLTMDRNGGYRGSQTLLRSVLSEKQELCFSVVSLLWQKLIASPEMQMSAESTSAHQGWRKVVDALCDIVSASPTKASAAIVLQAEKDLQPWIARDDEQGQKMWRVNQRIVKLIAELMRNHDSPEALVILASASDLLLRATDGMLVDGEACTLPQLELLEVTARAVHLIVEWGDSGVSVADGLSNLLKCRLSTTIRCLSHPSAHVRALSMSVLRDILNSGQINSSKLIQGEHRNGIQSPTYQCLAASIINWQADVERCIEWEAHSRRATGLTLAFLTAAAKELGCPLTC", "function": "Involved in regulation of circadian rhythm, and in the control of the photoperiodic flowering. Acts as suppressor of flowering under short-day (SD) and long-day (LD) conditions. Activates Hd1/CONSTANS gene.", "AFDB_id": "AF-Q9AWL7-F1-model_v4" }, { "swissprot_id": "P02969", "sequence": "MALSVNTNQPALIALQNLNRTNDDMQAVQTRINTGEAISTAKDTAAVWSHRPGAGDMSGLAREDEPGSGDIDRGRGPRAGESVSDLLKLMREKVVAAKDTSLTTTSRQALNADFQGLIKNLNQVLRSATFDGANLLDGSQAADMSFLADADAGQAITLTLQNLSLGGTINTLTATDDILDPVNAAGVLTRLDATLSAVNQAVGNIGTQAKQIDAHNTFVAKLNDVLETGVGNLVDADLAKESARLQALQVKQPLGAQALSIANGAPQIILSLFKGG", "function": "Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.", "AFDB_id": "AF-P02969-F1-model_v4" }, { "swissprot_id": "Q0W486", "sequence": "MIQLSNPRINKTFEALFALEDIREVFRQSLPTGLSSAEEQALKGKLAEIRKYLDEIEADGVGNGARQKYTGKIGSLDVRTREEEYINIHPIQAAGRLTPEARKAIIAYGDGYSTCDYCRKPFRLDKITKPGIQDFHGDLARWLNMDQARVVPGARRGFQAVASALVEKGDSVIVSALAHYTEFLAVEQAGGVVKEVPKNEQNLITADATAQKIEDVRRTTGKLPVLIMIDHFDYMFANEHDVYGIAKVAKQYGIPFLYNGAYTVGIAPVDGKKIGADFVVGSGHKSMASVAPSGVLATTDEFAAKVFRTTQMVGDVTNRKFGIKEVENMGCTLMGGTLLSMIASFPAVVKRSQPQNWEDEVRKSNYFLEQFRRVQGSNVLSEWPRKHTLTKVDTTGSYNKVAETHKRRGYFFNDELTAKGIIGEFAGATKTWKLNTYGLSWEKTKYLSEAFLDIARKYDLPIN", "function": "Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).", "AFDB_id": "AF-Q0W486-F1-model_v4" }, { "swissprot_id": "O43278", "sequence": "MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPGFVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLINCLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLVLKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL", "function": "Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).", "AFDB_id": "AF-O43278-F1-model_v4" }, { "swissprot_id": "Q1ED21", "sequence": "MAESLICNSTQSRVSSVLNRDVKQFGKKFMFDSNEETCWNSDQGESQWVLLEFPQHVKVSEVRLQFQGGFSGKSCKLEGSSKDENLRHILNFYPEDNNSLQSFPIPDAPLVQKLKIVFENSTDFFGRIIVYTLDILGEKDL", "function": "May act as a repressor of nr2c2-mediated transactivation by suppressing the binding between nr2c2 and its response element in target genes.", "AFDB_id": "AF-Q1ED21-F1-model_v4" }, { "swissprot_id": "P37178", "sequence": "MLTRLREIVEKVASAPRLNEALNILVTDICLAMDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVALAFDEGIVGLVGRLAEPINLADAQKHPSFKYIPSVKEERFRAFLGVPIIQRRQLLGVLVVQQRELRQYDESEESFLVTLATQMAAILSQSQVTALFGQYRQTRIRALPAAPGVAIATGWQDATMPLMEQVYEASTLDTSLERERLTGALEEAANEFRRYSKRFAAGAQKETAAIFDLYSHLLSDARLRRELFAEVDKGAVAEWAVKKIIEKFAEQFAALTDNYLKERAGDLRTLGQRLLFHLDDSVQGPNAWPERFILVADELSATTLAELPQDRLAGVVVRDGAANSHAAIMVRALGIPTVMGADIQPSVLHRRTLVVDGYRGELLVDPEPVLIQEYQRLISEEIELSRLAEDDVNLPAQLKSGERVKVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQSGFPSEEEQVAQYQGMLQMFNDKPVTLRTLDVGADKQLPYMPISEENPCLGWRGIRITLDQPEIFLIQVRAMLRANAATGNLSILLPMVTSIDEVDEARRLIERAGREVEEMIGYAIPKPRIGIMLEVPSMVFMLPHLANRIDFISVGTNDLTQYILAVDRNNTRVASIYDSLHPAMLRALSMIAQEAEKHGLDLRLCGEMAGDPMCVAILIGLGYRHLSMNGRSVARVKYLLRHIDFEDAQTLARRSLEAQMATEVRHQVAAFMERRGMGGLIRGGL", "function": "Component of the phosphoenolpyruvate-dependent nitrogen-metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I-Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr.", "AFDB_id": "AF-P37178-F1-model_v4" }, { "swissprot_id": "Q8VCW4", "sequence": "MEVEPPLYPVAGAAGPQGDEDRHGVPDGPEAPLDELVGAYPNYNEEEEERRYYRRKRLGVVKNVLAASTGVTLTYGVYLGLLQMQLILHYDETYREVKYGNMGLPDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAVGIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMSQKYYEYSHYKEQDEQGPQQRPPRGSHAPYLLVFQAIFYSFFHLSFACAQLPMIYFLNNYLYDLNHTLINVQSCGTKSQGILNGFNKTVLRTLPRSKNLIVVESVLMAVAFLAMLMVLGLCGAAYRPTEEIDLRSVGWGNIFQLPFKHVRDFRLRHLVPFFIYSGFEVLFACTGFALGYGVCSMGLERLAYLLIAYSLGASASSVLGLLGLWLPRSVPLVAGAGLHLLLTLSLFFWAPAPRVLQHSWIFYFVAALWGVGSALNKTGLSTLLGILYEDKERQDFIFTIYHWWQAVAIFVVYLGSSLPMKAKLAVLLVTLVAAAASYLWMEQKLQQGLVPRQPRIPKPQHKVRGYRYLEEDNSDESDMEGEQGQGDCAEDEAPQAGPLGAEPAGPCRKPCPYEQALGGDGPEEQ", "function": "Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.", "AFDB_id": "AF-Q8VCW4-F1-model_v4" }, { "swissprot_id": "P25604", "sequence": "MSANGKISVPEAVVNWLFKVIQPIYNDGRTTFHDSLALLDNFHSLRPRTRVFTHSDGTPQLLLSIYGTISTGEDGSSPHSIPVIMWVPSMYPVKPPFISINLENFDMNTISSSLPIQEYIDSNGWIALPILHCWDPAAMNLIMVVQELMSLLHEPPQDQAPSLPPKPNTQLQQEQNTPPLPPKPKSPHLKPPLPPPPPPQPASNALDLMDMDNTDISPTNHHEMLQNLQTVVNELYREDVDYVADKILTRQTVMQESIARFHEIIAIDKNHLRAVEQAIEQTMHSLNAQIDVLTANRAKVQQFSSTSHVDDEDVNSIAVAKTDGLNQLYNLVAQDYALTDTIECLSRMLHRGTIPLDTFVKQGRELARQQFLVRWHIQRITSPLS", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.", "AFDB_id": "AF-P25604-F1-model_v4" }, { "swissprot_id": "Q9VZW8", "sequence": "MYSPEEAAELKRRNYRSIREMIRLSYTVGFNLLDPSRCGQVLRIWTIVLSVSSLASLYGHWQMLARYIHDIPRIGETAGTALQFLTSIAKMWYFLFAHRQIYELLRKARCHELLQKCELFERMSDLPVIKEIRQQVESTMNRYWASTRRQILIYLYSCICITTNYFINSFVINLYRYFTKPKGSYDIMLPLPSLYPAWEHKGLEFPYYHIQMYLETCSLYICGMCAVSFDGVFIVLCLHSVGLMRSLNQMVEQATSELVPPDRRVEYLRCCIYQYQRVANFATEVNNCFRHITFTQFLLSLFNWGLALFQMSVGLGNNSSITMIRMTMYLVAAGYQIVVYCYNGQRFATASEEIANAFYQVRWYGESREFRHLIRMMLMRTNRGFRLDVSWFMQMSLPTLMAMVRTSGQYFLLLQNVNQK", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butyl acetate, isoamyl acetate, and hexanoic acid.", "AFDB_id": "AF-Q9VZW8-F1-model_v4" }, { "swissprot_id": "O66475", "sequence": "MLNKVFIIGRLTGDPVITYLPSGTPVVEFTLAYNRRYKNQNGEFQEESHFFDVKAYGKMAEDWATRFSKGYLVLVEGRLSQEKWEKEGKKFSKVRIIAENVRLINRPKGAELQAEEEEEVPPIEEEIEKLGKEEEKPFTDEEDEIPF", "function": "Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.", "AFDB_id": "AF-O66475-F1-model_v4" }, { "swissprot_id": "Q552Q7", "sequence": "MATRATRAASEVAKTKAATNLPSIRKRKSIENEEEESKHNTSINDDGELDSDIDEEDESKFEKEFTVKKRQKKSPAKTQQQPQKSITTPTKPTPTKTTSKPTKPSATTSPSQQKQSSQSSQNTSKKQATSSSSQQSTQQKKKETKIKYNLKPINIERLATYDQHMSGTLSNEKIIKRLKKLDEYLQDKKRGNTEGLEIVLEVLIDPKFADNKIFEIRLMTSCCLSEIFRIYAPTLPFDMVVLKVVFKLFTEQVLQGDKVDKKLFPQYFQMLERLSVIKVFALLALVDSSMLTPFFKDCLSRVHGDKEHQPMDIMFSTLLNTILESLEEVPTSLWNELLESLIEREKGGVPTSKAIFTHDLIETNSRFLQVHFDLFLQDLLEPEILAGGQQQQQQDSSLSNNGISKQLKKKKNEILFEMFNILPEFIYPALQNLEFDLEDVNASIRKGAAIVLSRCYSTESASDELIAQRPTLYTTFLNRFHDVDIKIRTVMMEFSEHFTTTSDLEMERVLKSVRDRFRDSEPDIRIKAIQIFQKYIIKNPELMNPELMSEYLERVRDKDSKVRKDAEISLSTVWRSVREKYGPIDDWSNTLIDCFSTIPNTLIHCLGLYDDDKYRIEIAFDSILLPQHSDVKNRSQVFLEIYKYLDESNKQLFKKYLEEKKSLRQEFLALIQFLKNPKVVGGSTTPTSKKSQPPQQQQQQQQQQQQQLQQPENDIEVYITHVDNLLPKFIGESSKKLVRQLITPSNKKILDLLVLISDINTTFQEQYNIKISIISKAQNESSFSEFIKYMVNKLAYSIVGKENIKYLLRGLRSDLGLDNFDKNNPIDLLEEFNEKIYEKEVKDGVPETLEVLLMLSQVYANIFDDYGDQLVGFLTCSKSIVYPVLQILSNSWKTLKLSKKTLKSTLDMLLRLTQVPQPTLARLAFKTFIKFATPALTSINSTNGKVDNNKLVVTLKDLANNLFDQLEDKSKNLLSILEVIGCLAKGYSLVLSEHLDTLDILLIKKIMTGVCTLDFNQKVQLNKSVEHHLNTSYSKDVLIKIAAIKCMSNYLLGLREITKKSHEMVNMLFEFYIGLDKNKTYNDLEKSHLKIHIAIGLLRVFQRSQYEKEITPQQFILICNSTSITTKQRGDPLIRRLIEKLAKVMILNRLPMKYMAAFGMAAQQPYSVLALVRKHSTSIIKTRRMVISRLAASLSMAKNLTEFYPESSMPYFLYVVSHREDFERDAPDYIESACYLNFFIDLLVEEADNYSIIHTIFTKLKRSTDALDKKSKNHIIAAELGLQILTHQYQQKKWKPQKHPIVIVLPEKFYIIHDDQDEMSIDDEVTSIKLPSLLPKRFKLPPLPSITDQNNNNNNNNTNSTNNDESEKDENNNNKNDNDNDNDNDDNSTTAVPQKSIISKPPAKKVSKKAAAKQKSPKKKTNKKKKQSSSEEEVSSSEEEDESQDEEVEN", "function": "May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.", "AFDB_id": "AF-Q552Q7-F1-model_v4" }, { "swissprot_id": "A5ABG4", "sequence": "MAKKAELRRSCTFCRTRKIACSGERICNACRSRSIECVYDLEIAKGRPRLNKTTSTRASISAGPAGPSPITLEDGEPGDGGHSITSAVNPSITPLTGVMAELEVMFRENFGEDPMAAPSNQFQDRVARFNRNLAAGRASQGPSTPAGSLTYPGFLALLMQDLAETVTGKFGDLGCHPFFGPGERFYRACMLQDTTKTMFDTACLPSPSTSTPSGGEADILADYNSHLITQHLEVWMSNHPLSIIISKSLLLRDLRSQTANRVLLAVMLADAHHFADNSAKGDRLLQWAVSQLSNIPAGQEDLTTAQITLLLGWFHVCRGHSRRALCYVGYAGRITTKLASQLHESPLTGQTHINGIDRGAVEAEMIHHMYWVMLALTVWSFIQMDMPLADLLPAQLLQVLPARTTPDSTLLQLDRATDNLSTLKPQLSSLQSVWLLSHVTVLSAHLYALYPQHLRSPPEPQPWQDLMLHRLNRLLRQGRSLTQICSDSRNALLDIIVVLQKESAHGRGEPTLLALYLAVSIHLLFPRDETGHHVHNSQTFVLSDTLFQQLIASIQDLKQLFPAISSVARHDSSQPASTGSAGLHFYLLALDALGRALMYVLTVWDRVTAVEQRVWQDRLRGLLDGGLAMHDLFEYDALLQDHRWRSVKKHLKTACKGIKGVLSGSRDQGSRSSSSSVSSLDLSFALPSRPTPAMGIPTSEEGRSEMMFPTMPSASGIPSSISSSISHTSREVGLSWPGDGQILPTQEQGPRESSHPAASDLSDFDLAPFVSLGSIDSMQNGDERSRIMQQFSPNPMSLPSFWHDPQFSPAHHLVGTMPPPSLISLADLGMGERGQKRSSEKLGGLSEGDTPGTSADGGTKRRMKGMSN", "function": "Transcription factor that regulates th eexpression of the gene cluster that mediates the biosynthesis of pyranonigrins, a family of antioxidative compounds.", "AFDB_id": "AF-A5ABG4-F1-model_v4" }, { "swissprot_id": "Q8RY22", "sequence": "MGDPLERLGSQASMATESVMKEDLCLEIDPPLTESVATAEDWRRALGKVVPAVVVLRTTACRAFDTESAGASYATGFIVDKRRGIILTNRHVVKPGPVVAEAMFVNREEIPIYPVYRDPVHDFGFFCYDPSAVQFLTYQEIPLAPEAASVGLEIRVVGNDSGEKVSILAGTLARLDRDAPHYKKDGYNDFNTFYMQAASGTKGGSSGSPVIDWQGRAVALNAGSKSSSASAFFLPLQRVVRALSFLQKSIDSRTDKPKAVHIPRGTLQMTFLHKGFDEIRRLGLRSETEQVVRHASPTGETGMLVVDSVVPSGPADKHLEPGDVLVRVNGTVLTQFLNLENLLDDGVGQILELEIERGGQPLSVSVSVQDLHSITPDHFLEVSGAVIHPLSYQQARNFRFPCGLAYVADPGYMLFRAGVPRHAIIKKVANEDISSLGDLVSVLSKLSRGARVPLEYMSHTDRHRKKSVLVTIDHHEWYAPPQLYTRNDSSGLWDAKPAIEPASVSPSIGNNGFPISQDISLCHHDTEPMHEVNVRGVTDIAAIMETSSGDGSQNDFGSEAKKQRVDEDSSDGIAANGSLYGSEFKSDDAMETDTTVLRDFEGATALSANASLAERAIEPALVMFEVHVPPSCSLDGVHSQHFFGTGIIIYHSSNMGLAVVDKNTVAISASDVMLSFAAFPVEIPGEVVFLHPVHNYALIAYNPSAMDPASASVIRAAELLPEPALQRGDSVYLVGLSRNLQATSRKSIVTNPCAALNIGSADSPRYRATNMEVIELDTDFGSSFSGALTDEQGRIRAIWGSFSTQVKYSSTSSEDHQFVRGIPVYAISQVLEKIITGGNGPALLINGVKRPMPLVRILEVELYPTLLSKARSFGLSDEWIQVLVKKDPVRRQVLRVKGCLAGSKAENLLEQGDMVLAVNKMPVTCFNDIEAACQTLDKGSYSDENLNLTILRQGQELELVVGTDKRDGNGTTRVINWCGCVVQDPHPAVRALGFLPEEGHGVYVTRWCHGSPAHRYGLYALQWIVEVNGKKTPDLNAFADATKELEHGQFVRIRTVHLNGKPRVLTLKQDLHYWPTWELRFDPETALWRRNILKALQ", "function": "Probable serine protease.", "AFDB_id": "AF-Q8RY22-F1-model_v4" }, { "swissprot_id": "Q9USV0", "sequence": "MQLLNFLICLFFIFKRCVFTVIGGEFSYDNIDKKPILVASYPEGSRFNVSASIKTLPDLVTLTFPKLVKDPGYVYEEAEKGDPESQFLIAMLYAMGPDERLGLSFPRNEPLSRIFLELSATQNYTYALLALAYKHLNGLSTPMSVDKGVELYKQVAHQISCLVQPLSHFAPDIAAEYPVDLYDLSRTSSYSVQKKDDIVEYLKDYALRGNNISAHISLATIYQYGTPGKLKDIKLAVKHYLAAIRLVNSGIPDSPSEAIKSIHNNPRHAPTTKETANSLSIAAFRLGCMALHGELGKPDPSLAYAWFEYGVSLNHSSSKAAIAYMYFMGYPVAENTESITKLLENALASNDPLAFAVAGKVSLANGQIDEATVHLIRAVSNGHLESVLHIADIYYGSNNQLSIAYYENFISRVLELFDVKTISFDPLTRHFAHRLSAELGNLMSQILAAKDRDPSTSYLKTVIFPTNEQTHRNARIAMNYYSRAAARNHIHSLIKIGDFYRMGLGTSAKPELAFSYYSQAAAIHPSALAYWRLGWMHEYGVGVPVDFEMAKKNYDNALMHDTRAFLAVTLARLRMRLSSPDSWFSNIYRILGKVTYKFLKLVQYFIINIFDILSPAGPDSQLPPEPPTLQVDRTPQQPDPQETSESLPSPNTEEMGESYNDIRFTYDYIDGRFLETACVTLIVVVVGLVLMRRHQQHRLQERRERIIRRQNRA", "function": "Component of the endoplasmic reticulum quality control (ERQC) system involved in ubiquitin-dependent degradation of missfolded endoplasmic reticulum proteins.", "AFDB_id": "AF-Q9USV0-F1-model_v4" }, { "swissprot_id": "P32599", "sequence": "MNIVKLQRKFPILTQEDLFSTIEKFRAIDLDDKGWVEKQQALEAVSKDGDATYDEARETLKHVGVDASGRVELDDYVGLVAKLRESKTGAAPQTTFNVAPNSTPIVSTAATGLQHKGKGTQAKIIVAGSQTGTTHTINEEERREFTKHINSVLAGDQDIGDLLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKKGKELNNFQASENANIVINSAKAIGCVVVNVHSEDIIEGREHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEDDETLEQFLRLPPEQILLRWFNYHLKQANWNRRVTNFSKDVSDGENYTILLNQLDPALCSKAPLQTTDLMERAEQVLQNAEKLDCRKYLTPSSLVAGNPKLNLAFVAHLFNTHPGLEPIQEEEKPEIEEFDAEGEREARVFTLWLNSLDVDPPVISLFDDLKDGLILLQAYEKVMPGAVDFKHVNKRPASGAEISRFKALENTNYAVDLGRAKGFSLVGIEGSDIVDGNKLLTLGLVWQLMRRNISITMKTLSSSGRDMSDSQILKWAQDQVTKGGKNSTIRSFKDQALSNAHFLLDVLNGIAPGYVDYDLVTPGNTEEERYANARLAISIARKLGALIWLVPEDINEVRARLIITFIASLMTLNK", "function": "Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity.", "AFDB_id": "AF-P32599-F1-model_v4" }, { "swissprot_id": "O83128", "sequence": "MSAHRIRARRITRRNVPLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLMLSLRRFRSLHTQTQRDGSVLVHAGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAAYMNARCYGRAIADCFHSARTLVLHPVRSRAKELPEVRKNAQDKRGECLGLDGGPFTCSSFQTVFARAGDWGYKRSPFQSPHGVELHAGRRLILSLCVRLTPGNPAQIRKHMQEKIADRISKGQFRFPSAGSAFKNNPAFGKPSGILIEEAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLRVVRQRVFETHGVWLEREIIFSGESVRMTSSSRDS", "function": "Cell wall formation.", "AFDB_id": "AF-O83128-F1-model_v4" }, { "swissprot_id": "P41411", "sequence": "MCETPIGCHTPRRCNRFIDSAALIDCTNKTNQREHSPSFSIEIPTTPSRKRTLASSHFQTPTKRIKYELGELQEEKTDLYPNFPAQLKENKKPKLPTTPQTPKTPKRTIQIVTPKSLNRTCNPVPFATRLLQSTPHRQLFPPTPSTPSTPSYNSTAKLSLRKSYRSAGVVGRENEKSIVESFFRQHLDANAGGALYVSGAPGTGKTVLLHNVLDHVVSDYPKVNVCYINCMTINEPKAIFEKIHSKIVKEEILENEDHHINFQCELESHFTQSANELYNPVIIVLDEMDHLIAREQQVLYTLFEWPSRPTSRLILVGIANALDMTDRFLPRLRTKHITPKLLSFTPYTAQEISTIIKARLKTAATTSEKNNPFTPIKSISEVSDDSINVVSQHADETPFIHPAAIELCARKVAASSGDLRKALDICRHAIELAEREWKAQHDNTLSSVDIPRASIAHVVRATSAMSQSASARLKNLGLQQKAILCTLVVCEKTSLSVADVFEKYSSLCLRDRLIYPLTSSEFCDVANSLETLAIIRLRTKQRNGKPQDRIISLLVPEMDVITAVGDIGTLKRFFDRR", "function": "Part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Plays a key role in coupling S phase to start and mitosis. Acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orc1, involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint. Together with orc2, plays a role in preventing DNA rereplication and resulting genetic instability.", "AFDB_id": "AF-P41411-F1-model_v4" }, { "swissprot_id": "Q9CC57", "sequence": "MSITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQAVAECGADAALEFGALFDGVRPPTVRVPDAALDAALAGLDPDVRDALQVMIERTRVVHADQRRTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVVASPPQFTSGGRFHGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDSDDCELAPVDMITGPGNIYVTAAKRLCRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQAEHDEMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAALGGRQSAIILVDDLEAGVKVVNLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSGGLSVQTFLRGIHVVNYTKTALKDISGHVITLAKAEDLPAHGEAVRRRFAR", "function": "Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.", "AFDB_id": "AF-Q9CC57-F1-model_v4" }, { "swissprot_id": "Q887D0", "sequence": "MISSRIGGAGGVELSRVNQQHDTVPAQTAHPNAVTAGMNPPLTPDQSGSHATESSSAGAARLNVAARHTQLLQAFKAEHGTAPVSGAPMISSRAALLIGSLLQAEPLPFEVMAEKLSPERYQLKQFQGSDLQQRLEKFAQPGQIPDKAEVGQLIKGFAQSVADQLEHFQLMHDASPATVGQHAKADKATLAVSQTALGEYAGRASKAIGEGLSNSIASLDEHISALDLTLQDAEQGNKESLHADRQALVDAKTTLVGLHADFVKSPEAKRLASVAAHTQLDNVVSDLVTARNTVGGWKGAGPIVAAAVPQFLSSMTHLGYVRLSTSDKLRDTIPETSSDANMLKASIIGMVAGIAHETVNSVVKPMFQAALQKTGLNERLNMVPMKAVDTNTVIPDPFELKSEHGELVKKTPEEVAQDKAFVKSERALLNQKKVQGSSTHPVGELMAYSAFGGSQAVRQMLNDVHQINGQTLSARALASGFGGAVSASSQTLLQLKSNYVDPQGRKIPVFTPDRAESDLKKDLLKGMDLREPSVRTTFYSKALSGIQSSALTSALPPVTAQAEGASGTLSAGAILRNMALAATGSVSYLSTLYTNQSVTAEAKALKAAGMGGATPMLDRTETALNNIRHPNRESLPHTFQKSTLSGIPRVAENAYHMGRGALQLPTQMAVDTVRVVDEGVLNAVASAREALKQPTKDDDALRALEEGLLDPR", "function": "Involved in the suppression of basal resistance and promotion of disease symptoms in plants. Mediates the ubiquitination and degradation, via the host proteasome, of a low-abundance immunity-associated protein in Arabidopsis thaliana. May be involved in the inhibition of a host vesicle trafficking pathway.", "AFDB_id": "AF-Q887D0-F1-model_v4" }, { "swissprot_id": "Q7M418", "sequence": "MIALFVLMGLMAAASASSCCSSEDRANVMHNWDAAWSAAYSDRRVALAQAVFASLFSRDAAAQGLFSGVSADNPDSADFRAHCVRVVNGLDVAINMLNDPAVLNEQLAHLSAQHQARAGVAAAHFDVMAEAFAEVMPQVSSCFSSDSWNRCFARIANGISAGL", "function": "The extracellular giant hemoglobin is able to bind and transport oxygen and hydrosulfide simultaneously and reversibly at two different sites.", "AFDB_id": "AF-Q7M418-F1-model_v4" }, { "swissprot_id": "P0CV27", "sequence": "MLVSMLLIIFPNGVSLSTPSLSSRNKFILRSRSSRLRFSARSFLSSASRLVNSSKMTLAFERLLRLRRVSFTKKFSSSDEDKSRDVRRRLRPASEATGAFAVRGADCAIAD", "function": "Secreted effector that partially suppresses the host cell death induced by cell death-inducing proteins.", "AFDB_id": "AF-P0CV27-F1-model_v4" }, { "swissprot_id": "Q6TNA6", "sequence": "MHSLFTLNLDLERAGKVICAQSLPFDTARETLLLLSPVGTQCCYMKNAALFLISHFNLIILESDTWLAYANEAGVNPEEGVADFIRQFNAALPEPVRVDALVGYCSSAPLALLAANQGACRTLLLLNGAYFLKDDGVIKSQYERDVERMMQSIPQGNCAQVYEAVSLLHTQSTYTPSDYRYQQVRPLRELSAFRQYLTFLNNLASLELVRIAQAVKTPTLVWCGSQDRYTDTASSRYIAQLLPHSELVEDPDGQHHDFVDGHERLYLTMTRFLTRHKQRAIQ", "function": "Involved in the biosynthesis of the phytotoxin coronatine (COR). Catalyzes the transfer of the aminoacyl group covalently attached to the pantetheinyl arm of CmaA to the holo-pantetheinyl arm of CmaD. During the shuttling process, CmaE generates a covalent-aminoacyl-S-Cys enzyme intermediate by the action of its donor substrate L-aminoacyl-S-CmaA and delivers it to the sulfhydryl group attached to the phosphopantetheinyl arm on CmaD.", "AFDB_id": "AF-Q6TNA6-F1-model_v4" }, { "swissprot_id": "Q12254", "sequence": "MIFKILCSLLLVTSNFASALYVNETTSYTPYTKTLTPTYSVSPQETTLTYSDETTTFYITSTFYSTYWFTTSQSAAIISTPTASTPTASTPSLTTSTNEYTTTYSDTDTTYTSTLTSTYIITLSTESANEKAEQISTSVTEIASTVTESGSTYTSTLTSTLLVTVYNSQASNTIATSTAGDAASNVDALEKLVSAEHQSQMIQTTSADEQYCSASTKYVTVTAAAVTEVVTTTAEPVVKYVTITADASNVTGSANNGTHI", "function": "Required for vanadate resistance.", "AFDB_id": "AF-Q12254-F1-model_v4" }, { "swissprot_id": "Q7ULX4", "sequence": "MSPEVLSARPGFVRNLMDVMMKPVLQLPPMTCQRIREIDSLAMEQFQMPGIILMENAGRGAAELIEELAPEGNVLILCGKGNNGGDGFTIARHLQLAGREVMILAMAATNELQGDAAIQAKIAEAAGIKIQVVGEAVEAGRLPATDIVVDGLLGTGAKPPLRGRYAEVVEAANASSAIRIALDIPTGMNGDTGETGETTFRADHTLTFAAPKVGFEKLGAARFTGEVHVISIGVPLELLRQFSV", "function": "Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.", "AFDB_id": "AF-Q7ULX4-F1-model_v4" }, { "swissprot_id": "Q9LUI2", "sequence": "MATVLHSESRRLYSWWWDSHIPKNSKWIQQNLSDMDSKVKAMIKLIEEDADSFARRAEMYYKKRPELMKLVEEFYRAYRALAERYDHATVELCHAHKTMAEAFPNQVPFDMIEDSASSSCSEPRTPEKMPPGIQPFYDSDSATSKRGLSQLTEYLGNSETEVESLKRTLVELGAEKEALNLQYQLSLNKFSRLEKDLEVAQKDVSGLDERASKAEIETKILAEALAKLEAERDAALLRYNESMQKITELEESFSHAQEDVKGLTNRATKAETEVENLKQAHSRLHSEKEAGLAEYNRCLEMISNLEKKVRDAEENAQNFSNQSAKAEDEIKALRHELVKVNEVKDGLRLRYQQCLETISKLEREVSHAQDNAKRLSSEVLAGAAKLKTVEDQCTLLESSNETLKLEADGLTHKLAAKDQEIFQKQNELEKFQSLIEDEHSRYLEIEVSLKTLQSLYSQSQEEQKVITSELQSRIGMLRDLETRNLKLEGDISSVKEENQNLSELNDSSMIFLETQKCEISSLKEIKEKLEEEVARHINQSSAFQEEIRRLKDEIDSLNKRYQAIMEQVNLAGLDPKSLACSVRKLQDENSKLTELCNHQSDDKDALTEKLRELDNILRKNVCLEKLLLESNTKLDGSREKTKDLQERCESLRGEKYEFIAERANLLSQLQIMTENMQKLLEKNSLLETSLSGANIELQCVKEKSKCFEEFFQLLKNDKAELIKERESLISQLNAVKEKLGVLEKKFTELEGKYADLQREKQFKNLQVEELRVSLATEKQERASYERSTDTRLADLQNNVSFLREECRSRKKEFEEELDRAVNAQVEIFILQKFIEDLEQKNFSLLIECQKYAEASSFSEKLIAELESENLEQQMEAEFLVHEIDNFRGAICQVFKALQVEADCKTADQKIAKERIPVSRVLGEINELKCSLSSAEYETQRLVIENSVLLSLLGQFQSDGMKLESEKRDVEKDLETIVHHYGMLKKDRLELLEMNRQLKSELIDREQRELELKAELQTEHLKFENLHESYMALHQDYSDALGKNKSLHLKFSELKGEICILEEENGAILEEAIALNNVSVVYQSLGSEKAEQAEAFAKNLNSLQNINSGLKQKVETLEEILKGKEVDSQELNSKLEKLQESLEEANELNDLLEHQILVKEETLRQKAIELLEAEEMLKATHNANAELCEAVEELRKDCKESRKLKGNLEKRNSELCDLAGRQDEEIKILSNLKENLESEVKLLHKEIQEHRVREEFLSSELQEKSNEFGLWDAEATSFYFDLQISAVREVLLENKVQELTGVCENLKDEAVTKTTEINQIKETVGFLEFEVSELKTQLSAYDPVVASLAEDVRSLEQNALSLMKLPVPAGRRREGVQNDEHQEAAVSQEPVGHCSTNLDNGIVLLQDMKTRIKTIKQAVAEEKKRRGKLRRRSSSHRSKDRKLFEEIELEDQFSGEIRQPRSPAMTESKNGSLMKDIPLDQVADTTSYGRSRRTSRGSSDQMLELWEEAAEPESSIKFLINNKNSKKPLIPRLHRRSRNPSVESQSEKMVGVVDKLELSRSTEDNAKILERLLSDSRRLASLRISLRDLKSKLEINEKPGKFTNPDFARVRKQMKEMEEAIFQLANTNEILSNEIEETGDVRDIYRKVVMEKSRIGSEKIEQMQQEMQNIERTVLKLEEGATKSKGRRKFSESRTVILLRDIIHKGGKRTARKKKNRFCGCMRSSGNEE", "function": "Plant-specific actin binding protein. Associates with F-actin at the plasma membrane and plasmodesmata. May be part of a membrane-cytoskeletal adapter complex.", "AFDB_id": "AF-Q9LUI2-F1-model_v4" }, { "swissprot_id": "Q2HEW7", "sequence": "MASAEETFFSAARSRRLACDRCHRHKLRCERSSVIVNGGVAVPLGPCKRCLKACIPCQTVQTISGAFTAAKTGDTPVPRRSAREADQAASPAKRAPSPARRPTASTPRNVPGLIHDDTLSGTDTAPFEISVADAAMLDVSNFDFSGSEFIDLGSNGVLSSPTPIQSPPDHGSLIRDSEIRDRTPIPPHNQPPPRYDDFANDLSCFGTMAPKDDTISTLPALTDVEKASTGSSKSAPERGPREECSQRLLEIHGLLLNELQCITPADVTDALMFPENGSFSGRTRTGQGPGNTVVHRVLFTSERLIELLSIIRAADTAINGDKREAGIGPRNTSSFVDLPIVISILTCYVGLLSVYHAIFSHIYEALRVYEPLRAAKIRQRAWTRRGSVPGPKPGPGLVQPRAIYGADEAGGRPALNVLGIRIQLEIMTHMLEQIDSALFGPRVAHGADGDEGRTDTINRGGEVMFGHPATKALLATMLSHEGYDSGVPVGPFADGDGDDDDDDGYMEGMRGCRMGFRTLMGLQKNIRRLLRTNSFG", "function": "Transcription factor; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells. Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C.globosum. Binds directly to asymmetric direct repeats present in the promoters of the chaetoglobosin A cluster genes.", "AFDB_id": "AF-Q2HEW7-F1-model_v4" }, { "swissprot_id": "Q6MAK3", "sequence": "MNFEIEQILTQIIAFLIMLGVLKKFVWKRLLNLIEERKQLIQSEFDKIENQKEEVTKLSEEYKAKLHDIDAEARRRIQEAVVKGRDIAHDIEQETRQKVTSLLNNAQEEMKLELAQAKEQLKKDVINISFAITEKLIHEKVDISKHQKLVEEAVEQVEIR", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-Q6MAK3-F1-model_v4" }, { "swissprot_id": "Q6NW34", "sequence": "MMAAVPPGLEPWNRVRIPKAGNRSAVTVQNPGAALDLCIAAVIKECHLVILSLKSQTLDAETDVLCAVLYSNHNRMGRHKPHLALKQVEQCLKRLKNMNLEGSIQDLFELFSSNENQPLTTKVCVVPSQPVVELVLMKVLGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKGVLKRLILLYEPLFGLLQEVARIQPMPYFKDFTFPSDITEFLGQPYFEAFKKKMPIAFAAKGINKLLNKLFLINEQSPRASEETLLGISKKAKQMKINVQNNVDLGQPVKNKRVFKEESSEFDVRAFCNQLKHKATQETSFDFKCSQSRLKTTKYSSQKVIGTPHAKSFVQRFREAESFTQLSEEIQMAVVWCRSKKLKAQAIFLGNKLLKSNRLKHLEAQGTSLPKKLECIKTSICNHLLRGSGIKTSKHHLRQRRSQNKFLRRQRKPQRKLQSTLLREIQQFSQGTRKSATDTSAKWRLSHCTVHRTDLYPNSKQLLNSGVSMPVIQTKEKMIHENLRGIHENETDSWTVMQINKNSTSGTIKETDDIDDIFALMGV", "function": "May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.", "AFDB_id": "AF-Q6NW34-F1-model_v4" }, { "swissprot_id": "A7TGF3", "sequence": "MSKINLTLDPPYNGEYYTGTEQISGHVSIQIEKPISIKSISIKLKGFIQTLTKIDSDQMFNNNSAMSPIQDNRAIHNIVEKSHRLFPPDNVWNALEGSHKPFKVKPGLYEYNFEFDKMPKRPECLARHKRDTDSFVKRNETRMPPSFNNNWKDMSRVDNIELYYYTLGKVIYIVQVEIELGKALAWYKPFNKFLHETLNIDYIPDAKDLIYVEDPEDYIARNSRVESDEQLIESIQNSLALNNNNNNTNNNIDNNNNRIKNKNININDGKIDNDGISTNSNTESNQVLTGDIGSNNTLMGRNNNMSVNSENRLNEHVIYKSSFSVQLPDESSVMWLEVRSRGLRHTYRRDYLFRQGSNKFDNIYLVLEGDIEEMFKMKINPRKIQLNLLEQTVYVAQGIANENVSSLRLVEALKICDDDDEFGRIFQFNPIQVPSNLHHRHHNNDAHNKKYEVELCLKDHSILKRIRFNKEDYVHRGNRLYSFKTCTIKRLFKFQLLIDWQINDKIRTTENIIDRTQIFCQVREKVNVVDTLPQYVEPPQYTETRHTTTP", "function": "May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.", "AFDB_id": "AF-A7TGF3-F1-model_v4" }, { "swissprot_id": "Q8T0W5", "sequence": "MCRYALIVLVVVVVATNLSEANIFDVPTCEPNRIYKTCGPACPPTCEDPDPDCNETPQCKAGCFCIPGLIENMKGGNCISPSLCP", "function": "May be a phenoloxidase inhibitor that stabilizes or inhibits venom phenoloxidase while it is stored in the venom sac.", "AFDB_id": "AF-Q8T0W5-F1-model_v4" }, { "swissprot_id": "P76364", "sequence": "MSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN", "function": "Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes. The intergenic region was not found to be necessary in another study. Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape. Also counteracts the effect of non-cognate toxins YfkI and YpjF.", "AFDB_id": "AF-P76364-F1-model_v4" }, { "swissprot_id": "Q54SU3", "sequence": "MSVASRIRDKLKNNLESSGGHSVVTSGTKVIRYRAGQRPDYAEAEDDQDSHFSNIQNQKSIKEAETNDPRLARFKNRSSNQDEPQSVEERKASRRRHHDDDNDNDTTTTTTTTTSRRIQKTEIIKEDDDNNNNNNNDTKKDHNDDDEDDDRRRRAKERYLKKKEEEEQKQKELEEKQQPFKDIEGESEEEGSSEYETDSEEDDEDEYWDQPPIFRPTFIKKDDRGTIKTDEQWEKEEQEQQAQLEREKEQRKIEAHRKLKDELDRDRKEQEAKELEQKEEEEYDDDEDQDGSKKLLWIQRELERVRLEIHTRLLAEFEKKEFARRRAMTDDQILKEDPSRSRTNIDNSQKKQLKFLQRDYHRGAFFQDDEYIKNKDFSAPTGEDKFNRELLPKVMQVKNFGKAGRTKYTHLKDQDTTEKDSLWNTNYNNKKKYNNNNNNSNSNSSNNNRDYNYRDRDNRS", "function": "Involved in pre-mRNA splicing as a component of the spliceosome.", "AFDB_id": "AF-Q54SU3-F1-model_v4" }, { "swissprot_id": "Q0IBN9", "sequence": "MKAISVLGSTGSIGTQTLAIVEDFPDQFRVVALSAGRNLSLLVSQIQRHRPDVVALADQALLAELKDRLMALPADTRPEPLPHLVGGPEGLDVVASWDSADLVVTGIVGCAGLLPTLAAIRAGKDLAVANKETLIAAGPVVLPELKKSGSRLLPADSEHSAIFQCLQGTPWSDTARLSTGVPTPGLRRIQLTASGGAFRDWSAADLEKATVADATSHPNWSMGKKITVDSASLMNKGLEVIEAHYLFGLDYDHIEIVIHPQSIIHSMVELADSSVLAQLGWPDMKLPILYCMSWPSRLETPWRRLDLTEVGQLSFRAPDPAKYPCMDLAYAAGRAGGTMPAVLNAANEEAVAQFLEEKIHFLDIPKMIEGACEQHKPDLAANPCLDDVLAVDQWARQAVREQVNRGTRLRGASMAA", "function": "Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).", "AFDB_id": "AF-Q0IBN9-F1-model_v4" }, { "swissprot_id": "Q5H8A4", "sequence": "MRLGSGTFATCCVAIEVLGIAVFLRGFFPAPVRSSARAEHGAEPPAPEPSAGASSNWTTLPPPLFSKVVIVLIDALRDDFVFGSKGVKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAVCVFFTAMDQTRLTQS", "function": "Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.", "AFDB_id": "AF-Q5H8A4-F1-model_v4" }, { "swissprot_id": "Q9W3F7", "sequence": "MQRVMPASWSSGGSLLPFRVSTTTKVVLFSLTAGVALMSVLSRFLRRRKPPRPPRRARKYTGRRNRNSMRSPNDLISIAGSKASARSGSPVGSTLAYSDRLSMASGSIGVGVLGVQNAGPGSSVVTQLTAQQLGMMGMEALDTVINFWEDALAAHYSPGGLPALLTTAEDSEFCREIQNLLEMAYTLQEQSELLFLDQRSVLFREEHSIDEAEEEAGEADDDRRSRKSGSVLSRAGSDPNFDSAESFASALDQVADLREFDGFIETSYEEYPLFQSALKHHDEYTVPCRTIRAELMHCSTDTEYLAKLHCVRLAFQFLFKDPAVGQWICDAGRQILTDLLCLGDKDTKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFYDICLDFIILDSFKDLDAPPASVTAVVQNRWLSNGFKETALTTAVWSVLKAKKRMLKFPNGFMSHFYVISEQISPLMAWGFFGPNENLRDICHYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTRVNNIGVKFSQ", "function": "Regulator of mitochondrial fusion required to maintain neuronal homeostasis.", "AFDB_id": "AF-Q9W3F7-F1-model_v4" }, { "swissprot_id": "B5ZCB8", "sequence": "MANFISLKRNEDILNIIKKQQKIHSNHIVVYFCETNLKKVRLAISISKKKFKLATQRNRIRRLIKAWFIAANVLVESYDIVVLVKPSFIDGSFVLNCDNIKKILQTIISKHKQNKINK", "function": "RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.", "AFDB_id": "AF-B5ZCB8-F1-model_v4" }, { "swissprot_id": "Q8KA23", "sequence": "MIEKIINQYQKKLFLIAYSGGIDSTVLLYKMLKIKEKNPQIKIRAIHINHNLHPSSKKWEEHCIKICHKYKIPIITKEIKILLKKNIEETLRIKRYNTIYNYLLNDEILLTGHHLNDQCETLFLSLKRGSGPTGLSGMSIENFLGKKRIVRPFLTKTKKELQKWACENNLESIEDFSNFNIDYDRNFIRHKLIPILEQRWPFFLKNCFRTTVICREETKLKNIFLKEKIQNLINFDESLNIQNFKNINKEVCKALIRYWISLKNIKMPSYKTIECIYNEIICSKKDSNPKIIIDKNEIRRYKTSLYFIKIQKDISNIFLFWHNTDKKLLLPEDLGYLIKNDKGFILPSPKKNELINIRFQLEGKILILGREKRRKIKKIWQEHNIPPWLRNKIPLLFYNNRFISAIGLFVIKEKIINKEKEIQKNWKISWINNVHFNRKNFFLFY", "function": "Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.", "AFDB_id": "AF-Q8KA23-F1-model_v4" }, { "swissprot_id": "O31701", "sequence": "MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVIISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQRRTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRISVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD", "function": "Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.", "AFDB_id": "AF-O31701-F1-model_v4" }, { "swissprot_id": "Q9WX14", "sequence": "MATGRAHRPATRSRGIPEATVARLPLYLRALTALSERSVPTVSSEELAAAAGVNSAKLRKDFSYLGSYGTRGVGYDVEYLVYQISRELGLTQDWPVVIVGIGNLGAALANYGGFASRGFRVAALIDADPGMAGKPVAGIPVQHTDELEKIIQDDGVSIGVIATPAGAAQQVCDRLVAAGVTSILNFAPTVLNVPEGVDVRKVDLSIELQILAFHEQRKAGEEAAADGAAPPVAARKQQRSTGSADQGPDGDVPAVMPA", "function": "Modulates transcription of respiratory genes in response to changes in cellular NADH/NAD(+) redox state. May play a general role as a sensor of cellular redox balance.", "AFDB_id": "AF-Q9WX14-F1-model_v4" }, { "swissprot_id": "P17405", "sequence": "MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC", "function": "Lacks residues that bind the cofactor Zn(2+) and has no enzyme activity.", "AFDB_id": "AF-P17405-F1-model_v4" }, { "swissprot_id": "H1ZZI3", "sequence": "MNCLMLIFVVFLLAFGVECKKDDYPVDTAKRNCMLDCNVWDDEGYCDKFCKGRKADSGYCYKLKAACYCYGLPDDSPTKTSGRCNPNVR", "function": "Inhibits voltage-gated sodium channels (Nav).", "AFDB_id": "AF-H1ZZI3-F1-model_v4" }, { "swissprot_id": "A5UJQ8", "sequence": "MYSQTKIAIPIFQAKKEDVIKVAEDCIEKGADVLEFRIDALDNPNFDDIKEIIEEINFPIIATNRISSEGGSFKGSEEERIDILLKCAPLVDYVDIELQSDDRYIKQIHDTGVTTIVSYHDFHKTPEINEIMYIVEKEQKLGDIAKVAFMPNDLDDTLKILAILSHCENTIAISMSDLGSYTRVMASKFDSPITFAAGRDVTAPGQIDIETMKSLLNMDLNLME", "function": "Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.", "AFDB_id": "AF-A5UJQ8-F1-model_v4" }, { "swissprot_id": "Q27017", "sequence": "LTSLILLVAVQAITEEDLELLRQTSAECKTESGVSEDVIKRARKGDLEDDPKLKMQLLCIFKALEIVAESGEIEADTFKEKLTRVTNDDEESEKIVEKCTVTEDTPEDTAFEVTKCVLKDKPNFFGDLFV", "function": "May be a carrier protein for lipids.", "AFDB_id": "AF-Q27017-F1-model_v4" }, { "swissprot_id": "J9VS56", "sequence": "MYGQQNNYGAPPPQQWGQAPPQGYQPGYQNGPPAVNYGAHPSQQQQWGAPPGPPQHQPYGAPPVNQYGAPPQHQQGYGGHSPQPPFGAPSPAPAGYGAPPTAPQGQYGAPSPYPQQPPQQGFGGPQQGYGSQPQGQSPMMYLGVPIPAPPPAVPVSTLAGYDARFDAERIRKATKGFGTDERTIIDTLSPLDAFQMDVLSRTYEQTVGRSLKSTLEKELSSWLEYTLVLLSLGPLGGDVYLLHRACNGMGTHEDLLNEVLLGRTNQEIFLLKEAYRRTYNQDLVQIVQGELSMKTERMFNMALSGQRDESPYLNHQLVQQDVETLYRAGPGKIGTDEIAICGILISRSKEHLKAIAQAFPARHRVSLSQMIHSEFSGHMRDALFFIARGVEADGDGVVRDCELLHAAMAGMGTKDERMIYRLVRNHWNRPRFNAIKNQYQVLYRNSLRRAVEGETTGKYEKALVGIIEQN", "function": "Does not appear to play a major role in virulence. May play a role in titan cell formation.", "AFDB_id": "AF-J9VS56-F1-model_v4" }, { "swissprot_id": "Q7WTB0", "sequence": "MRTIKEIALESGYSPATVSRLLNNDPNLSITADTKNKILEIANKLGYWEDHQEKKIKPTIALLYRVNHNEQLQDEYFTSLKQALVSTVERDALKMKTFYDIEDLIKNASLFQGFIGVGAEPIENAQLVKLHKVLPNGVFVDTNPAPELFDSIRPNLPFTVKNAIDLFIKNGINKIGFIGGVGPKHDHIQENDLRSITFVEYMKTRGMDTKWTCVEGPVSVENGYKLGKMVLAKYKNDLPEAFLIASDTLAVGVLQAFNEENVNVPKDTKILSINNSNVVKYVSPPLSSFNINQQEMIDMALDTLTHLIIRPDRPNIDIRMNTNLVVRKSFVPQEK", "function": "Negatively regulates the transcription of the lactose utilization genes lacL and lacM.", "AFDB_id": "AF-Q7WTB0-F1-model_v4" }, { "swissprot_id": "Q92JA9", "sequence": "MTNRHLAKFAYREEFKGDTEALAAAVREDASTGSTSQLPLEVQFGKMSNQKTVSVCIIGRPNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKAMVRCAWSSLHSADLVLLIIDSLKSFDDITHNIVDKLRSLNIVPIFLLNKIDIESKYLNDIKAFLTENHPDSLLFPISALSGKNIDGLLEYITSKAKISPWLYAEDDITDLPMRFIAAEITREQLFLNLQKELPYKLTVQTEKWEDLKDKSVKINQVIVVSRESYKTIILGKNGSKIKEIGAKSRMQMERFFGFPVHLFLFVKVRELWENNQEFYQYMKI", "function": "An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.", "AFDB_id": "AF-Q92JA9-F1-model_v4" }, { "swissprot_id": "A0R109", "sequence": "MSSETSSESTGHRPVLLVFADSLSYFGPTGGLPADDPRIWPNIVGEQLGWDVELIGRIGWTCRDVWWAATQDPRSWAALPRAGAVVFATSGMDSLPSPLPTALREMIRYVRPPWLRRWVRDGYGWVQPRLSPIARSALPPHVTVEYLEMTRNAIDFNRPGIPVVASLPSVHIAETYGRAHHGREPTVRAITAWAEEHHVPLVDLKAAVADEVFGGRGNPDGIHWSFEAHRAVAELMLKGLAEAGVTQRDSAT", "function": "Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can also be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis.", "AFDB_id": "AF-A0R109-F1-model_v4" }, { "swissprot_id": "Q8GW19", "sequence": "MATDGESISMSLAVATCVAMALFYVLILYVPTVILRLPSASSYTEFMIRRFICAAICTVASLVFTAFILPIKSWEASYILGVYGIRKDHLWQGVVYPLLLTSLVYAGSLVLKLFTLLESWKENGGGCSSFNYIRSFFQTIPASVLTSASNVSVWRNFIVAPVTEELVFRSCMIPLLLCAGFRINTAIFLCPVLFSLAHLNHFREMYIRHNRSYLRASLIVGLQLGYTVIFGAYASFLFIRTGHLAAPLFAHIFCNYMGLPVLYANGKGLVSAAFLGGVVGFVLLLFPLTKPLMYNDSTNDCPCWLGYCLWN", "function": "Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. The substrate specificity is only partially overlapping with that of FACE1.", "AFDB_id": "AF-Q8GW19-F1-model_v4" }, { "swissprot_id": "Q66GN2", "sequence": "MGRAKSMVSLLLVLFLVRAHVATTETTTEFIFHGFKGNQSEIHMQGDSTITSNGLLRLTDRNSDVVGTAFYHKPVRLLDSNSTNTTVRSFSTSFIFIIPSSSTSNGGFGFTFTLSPTPNRTDADPEQYMGLLNERNDGNSSNHVFAVEFDTVQGFKDGTNRIGNHIGLNFNSLSSDVQEPVAYFNNNDSQKEEFQLVSGEPIQVFLDYHGPTKTLNLTVYPTRLGYKPRIPLISREVPKLSDIVVDEMFVGFTAATGRHGQSSAHYVMGWSFASGGEHPLAAMLDISQLPPPPPNKAKKRGYNGKVIALIVALSTVISIMLVLLFLFMMYKKRMQQEEILEDWEIDHPHRFRYRDLYKATEGFKENRVVGTGGFGIVYRGNIRSSSDQIAVKKITPNSMQGVREFVAEIESLGRLRHKNLVNLQGWCKHRNDLLLIYDYIPNGSLDSLLYSKPRRSGAVLSWNARFQIAKGIASGLLYLHEEWEQIVIHRDVKPSNVLIDSDMNPRLGDFGLARLYERGSQSCTTVVVGTIGYMAPELARNGNSSSASDVFAFGVLLLEIVSGRKPTDSGTFFIADWVMELQASGEILSAIDPRLGSGYDEGEARLALAVGLLCCHHKPESRPLMRMVLRYLNRDEDVPEIHDNWGYSDSSRTDLGSKLVGYISSDRASSSHSHTSSSLTRISSTSLISGR", "function": "Involved in negative regulation of abscisic acid response in seed germination.", "AFDB_id": "AF-Q66GN2-F1-model_v4" }, { "swissprot_id": "P78345", "sequence": "MAAAPQAPGRGSLRKTRPLVVKTSLNNPYIIRWSALESEDMHFILQTLEDRLKAIGLQKIEDKKKKNKTPFLKKESREKCSIAVDISENLKEKKTDAKQQVSGWTPAHVRKQLAIGVNEVTRALERRELLLVLVCKSVKPAMITSHLIQLSLSRSVPACQVPRLSERIAPVIGLKCVLALAFKKNTTDFVDEVRAIIPRVPSLSVPWLQDRIEDSGENLETEPLESQDRELLDTSFEDLSKPKRKLADGRQASVTLQPLKIKKLIPNPNKIRKPPKSKKATPK", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.", "AFDB_id": "AF-P78345-F1-model_v4" }, { "swissprot_id": "Q9Y7Z9", "sequence": "MSSLVLRGVSRVEMPTISPTLGIYTRKFASQKILQRQFDVVIVGSGPVGLALAAGLQSNPVTQSLKVGLLDIQDTMKLKDWKFETYSNRCSSLTNHTRMFFDKIGAWDFARKDRIQPFQHILASDGLTNSSIHLDQKPGSEPMAFMSENVNLQYALLNSIIDKMNNNIKKPNLEFLMPCTITKLSKGENIYRTHIHTTTHGELTTKLLIGADGRNSIVRKYANISMPGWNYLTHAVVGTLKIDPLKGPAVAFQRFLPTGPLAYLPLPDNNATFVWSTRPHIASKLLRLPEETFVKFLNASFRLDYPDLSYLYQMDFSEPSKVNEQLDWRLQVKRNSNMQVPPVITEIVSGSRAAFPLRLAHVDEYVKEGIALCGDAAHNTHPLAGQGLNTGIQDVESLISALSFAIKHGQDIGSVFSLQPYFRDRYFKNHVYLGVVDKFHKLYAMENPVVTSVRTLGLSLFDRSASLKNFILSTVANGI", "function": "FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.", "AFDB_id": "AF-Q9Y7Z9-F1-model_v4" }, { "swissprot_id": "Q5NNR3", "sequence": "MTANQTKKSVPSFTSDIRQGVSNEGCLVLYSGGQDSATCLAWALEHFDRVETIGFDYGQRHKVELECRENLKQKLIQNFPDWAAHLGEDHMLDLAVLHQVSDCALTRETEIAFGEDGIPNSFVPGRNLLFFTFAATIAYRRGLRHIVGGMCETDYSGYPDCRDDTIKALQVAINLGLERRLVLHTPLMWLDKASTWQMAEEVGGKELVEIIRQESHSCYLGEREILHDWGYGCGHCPACELRAAGWESYQKSRS", "function": "Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).", "AFDB_id": "AF-Q5NNR3-F1-model_v4" }, { "swissprot_id": "Q9ZPW2", "sequence": "MATESSESEEEGKISGGNYKLIIDDDLREMGKNAAWSVSSCKPGNGVTTLRDDNLETYWQSDGLQPHLINIQFQKKVKLQLVVLYVDFKLDESYTPSKISIRAGDGFHNLKEIKSVELVKPTGWVCLSLSGTDPRETFVNTFMLQIAILSNHLNGRDTHIRQIKVYGPRPNPIPHQPFQFTSMEFLTYSTLR", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating the ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several other aspects of development. Involved in the control of endoreduplication.", "AFDB_id": "AF-Q9ZPW2-F1-model_v4" }, { "swissprot_id": "Q08170", "sequence": "MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS", "function": "Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.", "AFDB_id": "AF-Q08170-F1-model_v4" }, { "swissprot_id": "Q119Z5", "sequence": "MSVRVRLAPSPTGNLHIGTARTAVFNWLFARNQKGKFILRIEDTDQERSRPEYTDNILEGLSWLGLEWDEGPFYQCQRYELYQKATQSLLDKGLAYRCYCTAAELEEMREAQKARKEAPRYDNRHRNLTDLEKKAFEAEGRQAVIRFRIDDDQIITWNDMVRGKVTWKGSDLGGDMVISRAAGGDEVGQPLYNMAVVVDDMDMEITHVIRGEDHIANTAKQILLYEALGGKIPEFGHTPLILNKEGRKLSKRDGVTSISDFQELGFTPEALANYMCLLGWTPPDATEEIFTLAQAGQNFSFERVNKAGAKFDWDKLDWISSQYLHNLPVKQLTDKLIPIWQKAGYELDPEGDRSWLEQLVTLIRPSLTRLTDAVEMSELFFFPTVELNEDAKTQMQNEDSVKSINSILEIINADAPLLVADVKQTIKKVTQKVHVKKGVVMRSLRASLTGAMQGPDLIESWLLLHQKGFDILRFKKSIGQEIEDTKIEDTKKAETTPHKSKGEGNVLLKTTTPKSPALSKEQTQTTKPPKKGQTATPVATTPTATDVTENTSVGTQETQSQITTPVATTPTATDVTENTSVGTQETQSQITTPVATTPTATDVTENTSVETQETQSQITTPVATTPTATDVTENTSVETQETQSQITTPVATTPTATDVTENTSVGTQETQSQITTPVATTPTATDVTENTSVETQETQSQITTPVATTSTATDVTENTSVETQETQSQITTPVATTPTATDAETREQKVATQVETSILDDQKPVDTVTNQTVEVEQPNKIKEQFINIFFNFPDYINQLYQQYQGQLKLFGWLALVILTFTFMAVVIEALDGIPILSIIFELIGVIYLVWFVYRYLLKRSNRQELLDKIENIKREIFGKPS", "function": "Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).", "AFDB_id": "AF-Q119Z5-F1-model_v4" }, { "swissprot_id": "Q9GPH3", "sequence": "MSCRAMVSPPSRTARAGAVLASSPFVTSQPTEELLREFETVYGAVELTHLTPPQSPPGPATQLLLSYAQQAQCTALAPPAPLAPPQEAWQIVAPVPVNQLPEGYECDLDAVEELVRHRASQLASPQHSSSSANASPRSSPPPSPRSSSTDEDWSAPSRLKTRPVDDRRSRKKEQNKNAATRYRQKKKAEVEVLLKEEQTLRQRHTELGEKCSDLQREIRYLKALMRDLFKAKGLIK", "function": "Transcriptional activator that acts in the unfolded protein response (UPR) pathway. Acts during endoplasmic reticulum (ER) stress by activating UPR target genes via direct binding to the UPR element (UPRE) (5'-GGAACTGGACAGCGTGTCGAAA-3'). Activates expression of ER chaperones ERP72 and PDI.", "AFDB_id": "AF-Q9GPH3-F1-model_v4" }, { "swissprot_id": "P38078", "sequence": "MAGALENARKEIKRLSLDDTNESQYGQIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGEVIRINGDKATIQVYEETAGVTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIKDESQSIYIPRGIDVPALSRTVQYDFTPGQLKVGDHITGGDIFGSIYENSLLDDHKILLPPRARGTITSIAEAGSYNVEEPVLEVEFDGKKHKYSMMHTWPVRVPRPVAEKLTADHPLLTGQRVLDSLFPCVQGGTTCIPGAFGCGKTVISQSLSKFSNSDVIIYVGCFTKGTQVMMADGADKSIESIEVGDKVMGKDGMPREVVGLPRGYDDMYKVRQLSSTRRNAKSEGLMDFTVSADHKLILKTKQDVKIATRKIGGNTYTGVTFYVLEKTKTGIELVKAKTKVFGHHIHGQNGAEEKAATFAAGIDSKEYIDWIIEARDYVQVDEIVKTSTTQMINPVHFESGKLGNWLHEHKQNKSLAPQLGYLLGTWAGIGNVKSSAFTMNSKDDVKLATRIMNYSSKLGMTCSSTESGELNVAENEEEFFNNLGAEKDEAGDFTFDEFTDAMDELTINVHGAAASKKNNLLWNALKSLGFRAKSTDIVKSIPQHIAVDDIVVRESLIAGLVDAAGNVETKSNGSIEAVVRTSFRHVARGLVKIAHSLGIESSINIKDTHIDAAGVRQEFACIVNLTGAPLAGVLSKCALARNQTPVVKFTRDPVLFNFDLIKSAKENYYGITLAEETDHQFLLSNMALVHNCGERGNEMAEVLMEFPELFTEISGRKEPIMKRTTLVANTSNMPVAAREASIYTGITLAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKATALGSPDRVGSVSIVAAVSPAGGDFSDPVTTSTLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNVLNKYYDSNYPEFPQLRDKIREILSNAEELEQVVQLVGKSALSDSDKITLDVATLIKEDFLQQNGYSSYDAFCPIWKTFDMMRAFISYYDEAQKAIANGAQWSKLAESTSDVKHAVSSAKFFEPSRGQKEGEKEFGDLLTTISERFAEASE", "function": "VDE is an endonuclease that can cleave at a site present in a VMA1 allele that lacks the derived endonuclease segment of the open reading frame; cleavage at this site only occurs during meiosis and initiates 'homing', a genetic event that converts a VMA1 allele lacking VDE into one that contains it.", "AFDB_id": "AF-P38078-F1-model_v4" }, { "swissprot_id": "Q9SRV1", "sequence": "MKSVIFTEEKNLQRQNPLQKSEQQRRNFEMPSPPTTTSLSVTQTINGSHSFTIKGYSLAKGIGIGKHIASDTFTVGGYQWAIYFYPDGKNPEDNSAYVSVFIALASDGTDVRALFELSLLDQSGKGKHKVHSHFDRALESGPYTLKYRGSMWGYKRFFRRLMLETSDFLKDDCLKINCTVGVVVSEIDCPRLHSIHVPASDIGSHFGMLLENEDGSDITFNVSGEKFRAHRLVLAARSPVFESEFLDVTGEEDRDIEVTDMEPKVFKALLHYIYKDALIEDAESSSSSGSSVGPSASDTLAAKLLGAADKYKLPRLSLMCESVLCKDISVDSVANILALADRYNASALKSVCLKFAAENLIAVMRSDGFDYLREHCPSLQSELLKTVAGCEEELSGGGGKTRSVWGQFSDGGAETNGRQAQTWGDINGGAERSQSVWVEVVNANGSGRNNNDNNNSDDPMAELED", "function": "May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q9SRV1-F1-model_v4" }, { "swissprot_id": "B2FLM6", "sequence": "MHIDVTGRGPDLVLIHGWALQGGVFAPLVQRLADQFTLHLVDLPGHGHSREDTTPLRLPFVVGAIAAATPPAVWCGWSLGGLFALHAAATLPKVRGLAMIAATPRFVRGEDWPHAVEPAVFEQFGRELATDFGGTLERFLALDVMGSAHAREELRTLRQRLVERGAPTERALLEGLRLLESTDLRGALPTLGKPSLWIAGQRDRLVSPVAMQAAAALAPGAQALTIAHGGHAPFLGHADEVAAALQHFVAALSPADGGQ", "function": "The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.", "AFDB_id": "AF-B2FLM6-F1-model_v4" }, { "swissprot_id": "Q84Y18", "sequence": "MPATAGRVRMPANNRVHSSAALQTHGIWQSAIGYDPYAPTSKEEPKTTQQKTEDPENSYASFQGLLALARITGSNNDEARGSCKKCGRVGHLTFQCRNFLSTKEDKEKDPGAIEAAVLSGLEKIRRGVGKGEVEEVSSEEEEESESSDSDVDSEMERIIAERFGKKKGGSSVKKTSSVRKKKKRVSDESDSDSDSGDRKRRRRSMKKRSSHKRRSLSESEDEEEGRSKRRKERRGRKRDEDDSDESEDEDDRRVKRKSRKEKRRRRSRRNHSDDSDSESSEDDRRQKRRNKVAASSDSEANVSGDDVSRVGRGSSKRSEKKSRKRHHRKERE", "function": "May regulate CAX1 cation transporter.", "AFDB_id": "AF-Q84Y18-F1-model_v4" }, { "swissprot_id": "Q12263", "sequence": "MAINGNSIPAIKDNTIGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPERRIKTRDILKHPLLQKYPSIRDSKSIRGLPREDTYLTPLSESNSSIDATILQNLVILWHGRDPEGIKEKLREPGANAEKTLYALLYRFKCDTQKELIKQQQVKKRQSISSVSVSPSKKVSTTPQRRRNRESLISVTSSRKKPISFNKFTASSASSSNLTTPGSSKRLSKNFSSKKKLSTIVNQSSPTPASRNKRASVINVEKNQKRASIFSTTKKNKRSSRSIKRMSLIPSMKRESVTTKLMSTYAKLAEDDDWEYIEKETKRTSSNFATLIDEIFEYEKYEQIRKEKEELERKVREAKAREELERRRRKQEEKERARKLLEKEDLKRKQEELKKQIEIDISDLEQELSKHKEEKLDGNIRSISAPMENEEKNINHLEVDIDNILRRRNFSLQTRPVSRLDPGIMFSSPTEEVSPVEPKRTENERLTTEKKILETIRRSKFLGSSFNIDKELKLSKMEYPSIIAPQRLSEERVVSDSNDGYESLILPKDGNGVSQLKDSTATTAPVSDGRLRKISEIRVPQFTRKSRHFSESNKRLSVLSMYSTKESFTNLVDILKNGNLDVNNQQSQRIPTPRSADDSEFLFETVNEEAEYTGNSSNDERLYDVGDSTIKDKSALKLNFADRFNGSNEAKQTDNLHLPILPPLNGDNELRKQNSQEGDQAHPKIKSMIPESGSSSHTEKEEENEEKEEKKPEQHKQEEDQEKREKVVDDMEPPLNKSVQKIREKNAGSQAKDHSKDHLKEHKQDKNTAIGNGSFFRKFSKSSDKTMELYAKISAKQLFNGLEKLLRGWTQYGLKNIKSHPNNLTLTGKLSSDNIFSLRSTLFEVNIYPRGKMSVVQFKKVSGSFKAVKKLVNEVENVLNKEGVLQK", "function": "Serine/threonine-protein kinase which regulates the localization and the function of the septins during mitosis. Phosphorylates SHS1.", "AFDB_id": "AF-Q12263-F1-model_v4" }, { "swissprot_id": "P38616", "sequence": "MKFQVVLSALLACSSAVVASPIENLFKYRAVKASHSKNINSTLPAWNGSNSSNVTYANGTNSTTNTTTAESSQLQIIVTGGQVPITNSSLTHTNYTRLFNSSSALNITELYNVARVVNETIQDKSSAGAVVVANAKSLEAVSFFFSIIFDTEKPIVVTEDSAYAIPVANNKNATKRGVLSVTSDKLVYSGVFTPPTACSYGAGLPVAIVDDQDEVKWFFDASKPTLISSDSIIRKEYSNFTTPYGLLENGVPIVPIVYDGGYSSSLIDSLSSAVQGLVVVSSGSTNSTSSTIESTEIPVVYAQANTPLNFIDNKDVPKNAVGAGYLSPIKAQILLSIAAVNGVTSKSALESIFP", "function": "May be involved in cellular adaptations prior to stationary phase.", "AFDB_id": "AF-P38616-F1-model_v4" }, { "swissprot_id": "Q8PUA7", "sequence": "MIRHIDIAVQKIFEMKEKEPAKFKKLIDEGIMIGLGVDLGDRSREEYTAGHIKEQSRPKDPDYAAVTEAVIEGDSEETVRLTVALLEKGKDPTDLVLNALMPGIQTVCELYDIGESYMPEILLANEALIGGVKLCQERIGEIRYEGKVVSLVIEGDLHDIGKNIVAAILRANGFEVVDLGNDITVEAAVKAVKAANADLVVGTTLMSTTKEGLKVLAEVLESEDVPVACGGAAVDRRFVETFCNSVYGKTPLDAVKIAKNICAGKSWKEVRNDLH", "function": "Harbors a corrinoid prosthetic group and acts as a methyl group carrier in methanogenesis from methylated-thiols.", "AFDB_id": "AF-Q8PUA7-F1-model_v4" }, { "swissprot_id": "P0CT91", "sequence": "MRLAPQKPLLLSTVLHLLLSIWMLGFASLAGATVQEPLAASDTPKPVSAALFSSIERLSRLVDITYCVGNTGVWKPFACASRCNEFPTLTLERTWRTGILMSDSCGLIAVDHGTPRHDAGEGKDDPLAEKAIIVAFRGTYSLTNTIIDLSTIPQEYVPYPSPDDGGNEPPREPSHRCDNCTVHSGFLASWRHARKVVLPELKVLRQKYPEYPIRLVGHSLGGAVAMLAALEMRVSLGWRDTVVTTFGEPRVGNRQLCDYLNAVFELNLGDEMDPAEREYRRVTHADDPVPLLPPAEWGYSSHGGEFFISKKDLPPSVEDVLVCHGDHDENCIARGKSSAVSVPAGDYDDALSTLEEQDVMLADALPWIPARLKLWELFFAHRDYFWRLGLCVPGGDPANWGRKGGEGAAESISAEG", "function": "Lipolytic enzyme that possesses both lipase and acetylxylan esterase activity. Active towards p-nitrophenol esters of various carbon chain length with preference for medium-chain fatty acids (C-8). Also highly active on the acetylated compounds xylose tetra-acetate and oat spelt xylan.", "AFDB_id": "AF-P0CT91-F1-model_v4" }, { "swissprot_id": "G5EEV9", "sequence": "MPRFVYFCFALIALLPISWTMDGILITDVEIHVDVCQISCKASNTASLLINDAPFTPMCNSAGDQIFFTYNGTAAISDLKNVTFILEVTTDTKNCTFTANYTGYFTPDPKSKPFQLGFASATLNRDMGKVTKTIMEDSGEMVEQDFSNSSAVPTPASTTPLPQSTVAHLTIAYVHLQYEETKTVVNKNGGAVAVAVIEGIALIAILAFLGYRTMVNHKLQNSTRTNGLYGYDNNNSSRITVPDAMRMSDIPPPRDPMYASPPTPLSQPTPARNTVMTTQELVVPTANSSAAQPSTTSNGQFNDPFATLESW", "function": "Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa.", "AFDB_id": "AF-G5EEV9-F1-model_v4" }, { "swissprot_id": "Q09477", "sequence": "MISENGYMDLMRNCIKWNSRQMEDRKKRLRFPYYEHQTATAQRESRFTTRNVDHMYPSNDPNTVVQFATERWKKSKSQPPSDAVEMSMFLRENPSIQVAIDHLTPQVVGPTTESVSDSSNDSTTIRPSRQTQIKEEYRDDYVLDDELSPDEFGSDEDDWSSRKRRKGNLGPVQKATSSRKKVPTTRSSVSRLTPSRSIVKETKYEEPEEKTYPCDKCSAKYKSLAGLSYHQSYLHDQKSSQPLVKLLSPSIEISTSCDFCSGTAFMNKNTKLPEDLVSCHDCGRSGHPSCLNFNQNVTKIIKRSGWQCLECKSCTICGTSENDDKLLFCDDCDRGYHLYCLTPALEKAPDDEYSCRLCQVEFGDKASAPAKK", "function": "Probable transcription factor, involved in meiosis and stress protection.", "AFDB_id": "AF-Q09477-F1-model_v4" }, { "swissprot_id": "O43006", "sequence": "MKFPDLLRCSRAVSLARPDLPRNSPDVYDTKIPILQAITAKKCQRFRGDWGAKRKLPILKNRHISIQKFDTFEHQCAFISSDRFVRTLKRIYDLKLPVPLNDYEQISPYLLQKYNTFSSSNPKSRPTLPPGILYAKLKLLDSFSDSEKKRLSLVSFIQTKKVPLPFTYGKFAPDSKECLFGVSGVIAATSLKGITSTKNRYVIRSLNVDETGKTIPNITRENRSI", "function": "Has a role in meiosis.", "AFDB_id": "AF-O43006-F1-model_v4" }, { "swissprot_id": "Q8LRK8", "sequence": "MLLKFEASSELRLVDPSVSLTVLRKIRLSHLPDMTMTSESSGKKCGEGDGKVAGKSQRKVGLVYDETMCKHDTPNGKVDVECPDRIRVIWEKLQLAGVTQRCVVLGGSKAEDKHLKLVHTKKHVNLVKSISTKKKDSRRNKIASQLDSIYLNGGSSEAAYLAAGSVVKVAEKVAEGELDCGFAIVRPPGHHAESDEAMGFCLFNNVAVAASFLLNERPDLDVKKILIVDWDIHHGNGTQKMFWKDSRVLIFSVHRHDHGSFYPFGDDGDFNMVGEGPGEGFNINVPWEQGGCGDADYLAVWNHILIPVTKEFKPDIILLSAGFDAAIGDPLGGCCVTPYGYSVMLKKLMEFAHGKIVLALEGGYNLESLGKSSLACVQVLLEDKQIHGSSETYPLESTRRVIQAVRERLCTYWPSLDASMASNENLKNPSAERNSADALLREVEELKSLMAARDGELEARRKELKAKNKELEANEKELEAGLMLIRAREDVICGLHAKIESLQQERDEAVAKAERIDKELQEDRARSQEFKEDTEFCLSTLRREKELAIMAKNKDLEAKEKELEARLMLVHAREDKIHAKIERLQQERDEAVAKAERIDKELQEDRSRSRVGNGSFAFSQEFYEDMDLDELEPLSPEFNEDMDSEELEPFQVIKKNMERSHKKFIKDMECIKFIASERARVL", "function": "Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (Probable). Histone deacetylases act via the formation of large multiprotein complexes (Probable). Required for appropriate cellular patterning in the root epidermis. Involved in the differentiation of hair and non-hair cells in the root epidermis. Is not directly involved in the regulation of the expression of pattern genes. Regulates the transcription of certain kinase genes, which are components of a positional information relay system, by changing their histone acetylation status.", "AFDB_id": "AF-Q8LRK8-F1-model_v4" }, { "swissprot_id": "O97177", "sequence": "MYLDTKNLTASSTSALTAATASNSKSTRRMRNVWKPLSRLLKVGGKGRTAQATLAHPNNVDLNNTQQQQQQQQQELLIEDDTKSTPEESIHKYGLELRQLPEEEQVSLTQPPNTPTLISSVHVDKVSAQSCGNCQHGRNCQHRHHSSSNINSSSSSSNMNSSSATQLPSNLWDLQLPLQYISTDNGTFFWANTQDRVDDDLLHALLCQSFSQLPGTLC", "function": "Part of the Notch signaling pathway.", "AFDB_id": "AF-O97177-F1-model_v4" }, { "swissprot_id": "Q8U194", "sequence": "MFKILRKERLAPGINLFEIESPRIAKHAKPGQFVMIRLHEKGERIPLTIADVDISKGSITIVAQEVGKTTRELGTYEAGDYILDVLGPLGKPSHIDYFGTVVMIGGGVGVAEIYPVAKAMKEKGNYVISILGFRTKDLVFWEDKLRSVSDEVIVTTNDGSYGMKGFTTHALQKLIEEGRKIDLVHAVGPAIMMKAVAELTKPYGIKTVASLNPIMVDGTGMCGACRVTVGGEVKFACVDGPEFDAHLVDWDQLMNRLAYYRDLEKISLEKWERERRMV", "function": "A bifunctional enzyme that catalyzes the reduction of elemental sulfur or polysulfide to hydrogen sulfide with NADPH as electron donor. Also functions as a reduced ferredoxin:NADP oxidoreductase with a very high affinity for reduced ferredoxin. Exhibits a broad specificity for various physiological and non-physiological substrates with varied reduction potentials such as methyl viologen, benzyl viologen, FAD, FMN, methylene blue, 2,6-dichlorophenolindophenol (DCIP), cytochrome C and ferricyanide with highest preference for benzyl viologen. Does not reduce fumarate, succinate, nitrate, nitrite, sulfate, sulfite or protons. Does not possess any hydrogenase activity or NADPH-dependent glutamate synthase activity.", "AFDB_id": "AF-Q8U194-F1-model_v4" }, { "swissprot_id": "Q59QW5", "sequence": "MVPNTTKQVLNSLILDFLVKHQFQDTAKAFSKESPNLPSIPPLMDCSQGFLLEWWQVFFDLFQVRYGDGNSNNNPNNKLYHDYLRVQETQKHLFSQLPLIQQQQQQQHHFQQQQQQQGQQGQPFSQQQQRGIGVASGMQNQQHQFAPQHQGQPQGPGQTPQPPGSATNANFPINMPPNSNPQQQMFPINQQFAQMPNGQNQPSMEQQQRMAMMMKQQAMAAQRQQIPMNGLDPQQQQQMMNAVGGGPGNLNLQQQLFLQQQQQQQQQPKTTFQQQAQNQMNNLRQQAAMVAQQQQQQQQQQQQQGQLQGNLASAMGDSSSKNNSPVGARSNQQSTPQQNAAPAPSPHPSQQGQAQAQHNFQSQQQQQQQQMTKMAGSQGMKKNGQMSNGTSNNSSGRNNNALRDYQNQLMLLERQNKERLEFARNTGNSDSNPLSNGMMFAGQNQYSNSNQNQNQLPPNQQQPTPATFHPPPPPTTANGPQGQFNQKPSPATSNNSPALGNKSSPAMGNKKSKKESNSKKGKKANSNASTTANNKTSGQTTPNMSQPPSAGTEPKQPQPTEQMRQLQDKQQRPGSNTPSMGKKDFQPLTPRSEPISGETTKKKRKSGKLNDNNENSNGNSPKKQAKTNANSKNLDPIIKEEENGVLSLKKESSTSLQDQDLDLNPPLAPTQATAMSNTFNDDPFDVHLLDTQHHHQQNSNNSNHNRGQNLSNGSNNLSVSGPGMGMNNSVFGDSTHAFDINFNIDSLDDIWTTTGPGGDITGTGSGSGGAGGTDDDNFMGMNWAADPIENGD", "function": "Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections.", "AFDB_id": "AF-Q59QW5-F1-model_v4" }, { "swissprot_id": "Q9FFU6", "sequence": "MCDQRPNLLGSLVLLGFFIFFVNGEECSNSSSLIGHESEFKMLQHQLRGVFTVVDDCSFRVSRFDMLSGSEVHWWGAMSSDFDNMTNDGFVISDQKLNQTFKNSSFIVRLLGNVTWDKLGVVSVWDLPTASDFGHVLLSNATESDTSKAESPPSESNDVAPGKSNNSEPFKAPTMFDNCKKLSDKYRLRWSLNAEKGYVDIGLEATTGLLNYMAFGWAKPNSTSNLMLNADVVVTGIREDGFPFADDFYITESSVCSVKEGTATGVCPDTVYEEADSVGSSVNNTKLVYGHRIDGVSFVRYRRPLNDSDNKFDFPVNSTESLTVIWALGVIKPPDVINPYYLPVNHGGVESENFGHFSLNLSDHVDECLGPLDADNKYDQDVIIADAHAPLVVTAGPSVHYPNPPNPSKVLYINKKEAPVLKVERGVPVKFSIEAGHDVSFYITSDFLGGNASLRNRTETIYAGGQETHGVLSSPSELVWAPNRNTPDQLYYHSIFQEKMGWKVQVVDGGLSDMYNNSVNLDDQQVKFFWTIVGDSISIAARGEKKSGYLAIGFGSEMTNSYAYIGWFDRNGTGHVNTYWIDGESASAVHPTTENMTYVRCKSEEGIITLEFTRPLKPSCSHRDRPECKNMIDPTTPLKVIWAMGAKWTDGQLTERNMHSVTSQRPVRVMLTRGSAEADQDLRPVLGVHGFMMFLAWGILLPGGILSARYLKHIKGDGWFKIHMYLQCSGLAIVFLGLLFAVAELNGFSFSSTHVKFGFTAIVLACAQPVNAWLRPAKPAQGELISSKRLIWEYSHSIVGQSAVVVGVVALFTGMKHLGERNGTENVDGLNLALGLWVFLCVVTVAYLEYRERGRRRARNLSRGNWVLGNVEEDDSIDLIDSRGGFRDKDDEDRNGGRMEIQLEPLK", "function": "May act as a catecholamine-responsive trans-membrane electron transporter.", "AFDB_id": "AF-Q9FFU6-F1-model_v4" }, { "swissprot_id": "P48619", "sequence": "MAAGWVLSECGLRPLPRIYSRPRIGFTSKTTNLLKLRELPDSKSYNLCSSFKVSSWSNSKQSNWALNVAVPVNVSTVSGEDDREREEFNGIVNVDEGKGEFFDAGAPPPFTLADIRAAIPKHCWVKNPWRSMSYVLRDVVVVFGLAAVAAYFNNWVAWPLYWFCQGTMFWALFVLGHDCGHGSFSNNPKLNSVVGHLLHSSILVPYHGWRISHRTHHQNHGHVENDESWHPLSEKIFKSLDNVTKTLRFSLPFPMLAYPFYLWSRSPGKKGSHFHPDSGLFVPKERKDIITSTACWTAMAALLVYLNFSMGPVQMLKLYGIPYWIFVMWLDFVTYLHHHGHEDKLPWYRGKAWSYLRGGLTTLDRDYGWINNIHHDIGTHVIHHLFPQIPHYHLVEATEAAKPVMGKYYREPKKSGPLPLHLLGSLVRSMKEDHYVSDTGDVVYYQKDPKLSGIGGEKTE", "function": "Chloroplast omega-3 fatty acid desaturase introduces the third double bond in the biosynthesis of 16:3 and 18:3 fatty acids, important constituents of plant membranes. It is thought to use ferredoxin as an electron donor and to act on fatty acids esterified to galactolipids, sulfolipids and phosphatidylglycerol.", "AFDB_id": "AF-P48619-F1-model_v4" }, { "swissprot_id": "Q8BXQ6", "sequence": "MDIKLDPSRDDLPLMANTSHMLVKHYILDLDVDFGNQVIEGNIVLFFGDGNRFKNQSRSTQETFQMESEEADIFRTAEPCHVPEMDSSTFSPKMGHRECAVCGKGDQDAFDNDGNHDNQERDSEISSSKYCCDTGNHGKRDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTKAPKLLATPEKLRCEIVRDLVALPADAWREQLDCYTRCSQAPGCGELLIDSDNWSLRIRKTGTSTPADFPRAIRIWYKTKPEGQSVAWTTDQNGRPCVYTMGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTPLREGYMSWHYYVTMPMPASTFAIAVGCWTEMKPKASPPDDLMTEHSLPLSPSEADLRYDNTCNHMEYPCRFQSASAASQDIIPYRVFAPVCLEGACQEALLWLIPSCLSAAHSVLGTHPFSRLDILIVPTNFPSLGMASPHIIFLSQSTLTGTSHLCGTRLCHEIAHSWFGLAIGARDWTEEWLSEGFATHLEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELRNSPEGMQVLRPNKEETGHVSASGASVVKHGLNPEKGFMQVHYLKGYFLLRFLTRTLGEKIYFPFLRKFVHLFHGQLILSQDFLQMLLENIPENKRLGLSVENIVRDWLECSGIPKALQEERKAEDCSPSRLARQVGSEVAKWIRVNRRPRKRKRGKREVAFEKLSPDQIVLLLEWLLEQKTLSPQTLHCLQQTYHLPEQDAEVRHRWCELVIKHKYTKAYNQVERFLLEDQAMGIYLYGELMVSEDARLQQLAHRCFELVKEHMDRASAQVVTEMLF", "function": "Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates.", "AFDB_id": "AF-Q8BXQ6-F1-model_v4" }, { "swissprot_id": "Q9CPE8", "sequence": "MQAKSICFIGGGNMAQAIIFGLLKQGYPANQITVSDPNAAKRQCLAEKGVNTVEASQTDTQDAVETSEVLLLAVKPQMIAAVCQGLSAVDFSQKLVISIAAGVSVTKLQSRLPTAKQIVRVMPNTPALVAEGMSGLFAQNSLKPEYKQFTQDLLNAVGKTCWVTQEADMHTITAGSGSSPAYFFLFMEAMQQALCQMNMDEDTARLLVQQSALGAAKMVIENPDLPIATLRENVTSKGGTTAAALQVLNQQQLQHIVQQAMQACVERSQQMEKLF", "function": "Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.", "AFDB_id": "AF-Q9CPE8-F1-model_v4" }, { "swissprot_id": "P35709", "sequence": "MKLLLLLALLVGAVSTRHLNVDTSSLQSLQGEESLAQDGETAEGATREAASGVLMPLREEVKEEMEGGSGSEDDPEEEEEEKEMESSSELDMGPEDVQCPKEEDIVKFEGSPGCKICRYVVLSVPKTFKQAQSVCQRCFRGNLASIHSYNINLQVQRSSRILNVAQVWIGGQLRGKGHHKHFHWVDGTLWNFWYWAAGQPWRGNNSGRCVTLCARGGHWRRSHCGVRRAFSCSY", "function": "MBP may play some important roles in the allergic reactions and inflammations, since MBP is capable of releasing histamine from mast cells and damaging the epithelial cells of bronchial tubes. Antiparasitic and antibiotic.", "AFDB_id": "AF-P35709-F1-model_v4" }, { "swissprot_id": "Q7UP93", "sequence": "MLEELKEEEIVNKIGGRFKLSTLIQKRLVQLNQGSRALVSVDTHDKMSIVLQEIVQDKIFLNMENEIETVDDLDAIVAASEAPELDPSDL", "function": "Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.", "AFDB_id": "AF-Q7UP93-F1-model_v4" }, { "swissprot_id": "Q0CZG7", "sequence": "MWLSVALLTLLDGALAAPARQHSGAFDMPLTWTPFGFTTDAIQIGTPPQPLVCFVDWTWIGQYAFTPRCHGGSQGTYACLQHGQPLYNETESRTFANQSVLYPERTWNPNHFFFYNDLSVGFGSDIERVGPDHQARVTLQLADMHFQLDMVYPFGGVYGLSPVFKSDNASTQSPFYQMWQQGVYRSPLVSFVYCHNSTFDQPTPRRELCHGKDGLQTLGGPSPVLSLSDKNNSSPILWYDNIVFPPVNEIEFVYQPAVYNYWALRLTRHLIGDEEQALNTSIGGNPGAIFDHASYGRGVPMSENSYRRLIEITGGRPVVLDANVAPNNGNQSFVSVDCEKVSSFPNVKYVFEGHDRVWEVTPANYVERREVDGKEVCVLNVRTLGEGDWIIGNFGETFAKDKVVLFDFDKLRVGLADVPAAAY", "function": "Aspartic protease-like protein; part of the gene cluster that mediates the biosynthesis of pyranterreones, a family of antioxidative compounds. The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase pytA that condenses 4 malonyl-CoA units ato the acetyl starter unit by the modular PKS of pytA. The acyl chain is then connected to an L-serine through the amide bond by the modular NRPS of pytA. A tetramic acid is formed and released from the PKS-NRPS pytA to give pyranterreone 5 with the help of the thioesterase pytI. Pyranterreone 5 could be methylated by pytC to afford pyranterreone 6 (Probable). Both pyranterreones 5 and 6 are subsequently oxidized by the FAD-linked oxidoreductase pytB and the cytochrome P450 monooxygenase pytD to form the fused gamma-pyrone core, resulting in pyranterreones 7 and 11, respectively. The hydroxy group at C-8 of pyranterreones 7 and 11 are dehydrated by the aspartyl protease pytH to form a delta-7 double bond to give pyranterreones 3 and 1, 2 accordingly. The exo-methylene of pyranterreone 3 could be reduced into a pendant methyl by reductase pytE to provide pyranterreone 4, also known as cordylactam (Probable). Pyranterreone 4 can be reconverted to pyranterreone 3 through pytB-catalyzed dehydrogenation or further oxidized to pyranterreones 9 and 10 (Probable).", "AFDB_id": "AF-Q0CZG7-F1-model_v4" }, { "swissprot_id": "P62360", "sequence": "MIPEGTRFLLPPEARLKAEVVGKLQHLFRRHGYEPVELPALELYDPDHPLAERAFKLVDKTGEVLALRSEFTTLLAKLLRAHLGEGAHRFQYAGPLWLREADAELGRLREYTQVGLELLGATGPLADAEVLELAFAALEALGVQGEVEVGLPSLVGEVLKASGLPEALQRRAQQAIHRKNLPELKGLLAESPVPEEARKVLLALPDLYGGREVLKEARGLPLPPKAQEALAQLERTLDLLGRPVLLDLGMARRYEYYSGIFFRAYTPGFGLPLLGGGRYDGALFPKAAGFALGVERLLEALRLPKEEEPPEVLALDLKALRRFARERRTELFHGEDPVAYARRRGIPFLARGEELFRVEEA", "function": "Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.", "AFDB_id": "AF-P62360-F1-model_v4" }, { "swissprot_id": "Q6C3D7", "sequence": "MCFNLPLPHLPPYLPFITSSFFFFSFFPFSLTNTDAPIEFETTIIDPAEQTSHHVSESRPTHLSFSSSSESPRDQSREQSSRDVSASPVFPKRQQSLLRLDEHMAGGAGESRDEPHGEPSDDAHKSRASSTSSSSSFGQSWNQSSASQRASVSSMGGVDVAQKRPGPSSGGLTGASAASGMPPAPTSQAPAIPPITPQMQTGAFEQYTPQTAPPIPTQSQLGQDGRKRAATLDRQQQYVPSYGYSSPANGERGGPTGGTPGGTPMSPGGVAHVTSPGGGPSAASVHRSFSTTTPHAPTKNSRRIVSTSAAPMRKQIDDANAALGRAVDPSRDSQPMQSRDKRSKSISSRGGMKGVFSNLVSSMGTLSRKNTTVRRSESDTSAPSTPKISGPYDAKHVTHVGFNFDTGEFTGLPKPWQKLLSESGISKVEAEQHPQAVMDIMAFYTDQKDDGVWQKFGGANQAGSGATATTPYNAQNGFSPIASPGATTPTLGALNLGTPLSVDLDTEGDTSTSTGGGGGVGGGDYFAKPRSAPFPPAAGGGSASSSTATLGTGATASGGATTATPAIPSRDRTRESSLSSGTSNQGPPVTPLALSQSRQNLREEAPATPEEKPLAHFVASRKAPRPPSASPKKTGGAGASGDSGAGAAPPSAAPKSPPPRPPPAPPLGVPSVHAPNSEYRQKMITQLEAFNAKRQQERAERHAQKQKLAAAHAQAVQRQQRQQQQQQQQQQQQQSAQQGAMPSVMPQMQHGSMQQAQQSVSGGSSGLTPQQKQLIQQKQLLELQKATGGQVGGPVTSSTQQVLSNPAAAAAASQRKREQRLRKDQQVVARLNQICTPGDPTKLYRNLVKIGQGASGGVFTAYEVGSNLSVAIKQMNLEHQPKKELIINEILVMKDSKHKNIVNFIDSYLHGGDLWVVMEYMEGGSLTDVVTYNMMTESQIGAVCRETLLGLQHLHSKGVIHRDIKSDNVLLSMRGEIKLTDFGFCAQINESNLKRTTMVGTPYWMAPEVVSRKEYGSKVDIWSLGIMSIEMIEGEPPYLNESPLRALYLIATNGTPQLKEPDALSTIFKAFLAWALQVSADQRASASELLKHEFLLTADDVSTLAPLVKAARMAKIQEKNEKAQR", "function": "MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle.", "AFDB_id": "AF-Q6C3D7-F1-model_v4" }, { "swissprot_id": "P44942", "sequence": "MKSILDIFTRGFIQVQKTVFFATALLFAFSLFTQAEMVDTYQFQNQDDRTRAVELAKSLRCPQCQNQNLVESNSPIAYDLRLEVYKMVDEGKSNQQIIDKMTARFGDFVNYKPPFKWNTALLWLLPVALLILAAVLLYFSNRKKQFSEKVVAQQLENDEIISLPSTFGSSPRKQGEPSKLSKGKVNSKIYFVLFTLLIAIPATYYFSLDRFSRVQQGEQSMIEQHNQNVEMNDEHKNENVIEKLQNKLRTDPNNAETWLQLGEAYVQNNEFDSALVAYSNAEKLSGSKPNILGLAATALYYQAGQQMTQKVEQLLNEALAKDKNEVSSLSLLATIALENRQYQQAGMYLQQLLDSGNAAVDRRSVIQRMKMLDFLQRGEKGQNP", "function": "Possible subunit of a heme lyase.", "AFDB_id": "AF-P44942-F1-model_v4" }, { "swissprot_id": "Q6FUZ2", "sequence": "MSEHHSKRALSLDDLVNHDENDKSKLQKLADNESSVRSDDNRPGAIENIVNGNNSNSDLNSNGVIEEDTDTDDDVGGEFTFDNGITFDYDKQDRFSPEKKRIQARKKDTSKTTPSISNESPSNSKESSVPVDPLSSNISATDRKDSSEEKPDLTGPELVKEPDTNEYKRPSIQSITNAEDTTYNDHKAAGMEKTSNKHSLPNILSDSIDETVTEEHKPKTETEQTITEYQQENKQKDNVNESNSEETHDIKNDNMNQVEKIFQEKTSTLSKKNSVKKDLELLNEISASSKPNKYKNTPIWAQKWKPTVKALQNIDTNDFKIDNSILDIIPDDDLTKSVQDWVYATLYSIDPDLRPFIELEMKFGVLLESKSPDRVNPPVSSQAVYTDMDAHLTPNVDETVFKELSKYIQSLSEITENAGKFNVIEAQTKDAVYRVGTSTQRPRFLRMSSDVKTGRIGAFIEKRHISQLLIYSPKDSYDVKLSINLELPVPENDPPEKYQHQTPVSERTKERVSYIHNDSCTRFDITKVQNHNKGIKSNDVEITHEIELEINTPALIKAFDNIMTDSKEYATLIRTFLNNGTIVRRKLSSLSYEIFEGQKKIQ", "function": "First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.", "AFDB_id": "AF-Q6FUZ2-F1-model_v4" }, { "swissprot_id": "Q21Y60", "sequence": "MTRIVVTGAAGFIGSNIIQGLNARGLNDIIAIDDLTQGDKFRNLAHLKISDYVDASVFYDLFANGAYGQIEAVFHEGACSDTMESNGKYMMDNNYATSVNLFQACQKRGARLLYASSAATYGGSDTFREDPAFERPLNVYGYSKLLFDQRMRRECGNDFRRSVAGKTGQVVGFRYFNVYGPHEQHKGRMASVAFHQFHQFQAEGKVKLFADYGGYAAGAQMRDFIFIDDVVAVNLWFFDHPGVSGIFNLGTGRAQPFNDVASSVVNALRGLSGQTALGLEALTEAGLIEYIPFPDALRGKYQSYTQADLSALRATGCDHPFADVQTGVSNYVQWLAQQDS", "function": "Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.", "AFDB_id": "AF-Q21Y60-F1-model_v4" }, { "swissprot_id": "A0A0H3NGF1", "sequence": "MDQLYMTVQDYLLKFRKISSLESLEKLFDHLNYTLTDDMDIVNMYRAADHRRAELVSGGRLFDVGQVPQSVWRYVQ", "function": "Binds to H-NS and modifies the range of genes it silences; H-NS alone silences 'core' genes while the H-NS-Hha complex (and presumably also H-NS-YdgT) silences genes acquired by horizontal gene transfer. Plays a role silencing virulence factors in the absence of factors that induce pathogenicity.", "AFDB_id": "AF-A0A0H3NGF1-F1-model_v4" }, { "swissprot_id": "A6L997", "sequence": "MGFNEFMTKLFGNKSQRDLKEITPYVDKVKAVYPSIKALSNDELRAKTDEIKQRIQDYVAEEKAQVEELRKGIEDKELEEREAIWAEVDKIEKAITDKMEVVLEQSLPEVFAIMKDTARRFAENEEVVVTANQFDRDLAARFDFVRIEDDKAIYANHWKAGGNEITWDMIHYDVQLFGGVVLHKGKIAEMATGEGKTLVATLPVFLNALTRNGVHVVTVNDYLSKRDSEWMGPLYMFHGLSVDCIDKHQPNSEARRKAYEADITFGTNNEFGFDYLRDNMAISPKDLVQRKHNYSIVDEVDSVLIDDARTPLIISGPIPRGEEQLFEQFRPNVEVVVNAQKDLCSKLLIEAKKKMASDDQKVVEEGSILLYRSFKGYPRNKALIKFLSEQGVKAQMLKTEEYFMSENMRHMHEATDELYFVIDEKNNSIELTDKGIDLLTGKTDDPTFFVLPDITSQLSQLENMTGTEEEKQAQKDEILANYSVKSERVHTINQLLKAYTLFEKDDEYVVMDNKVMIVDEQTGRIMDGRRYSDGLHQAIEAKERVKVEAATQTFATITLQNYFRMYHKLSGMTGTAETEAGEFWDIYKLDVVVIPTNRPIARNDMNDRIYKTKREKYNAVIEEIVQLTEAGRPVLVGTTSVEISELLSRMLTMRKIQHNVLNAKLHQKEAEIVALAGQKSTVTIATNMAGRGTDIKLSKDVKDAGGLAIIGTERHESRRVDRQLRGRAGRQGDPGSSVFFVSLEDDLMRLFASEKIAGLMDKLGFKEGEVLEHNMLSKSVERAQKKVEENNFGIRKRLLEYDDVMNSQRNVIYTRRRHALMGERIGLDVLNTIYDTSTAIADQHAEDFEGFKLELFKTFAMESPFTEDEFKSMKPEQLVEKLFEEALKTYKRRMERMTQVAHPVIKQVYENQGAMYENIMIPITDGKRMYNVSCNLKEAYDTECKAIVKSFQKSIVLHMIDEGWKEHLREMDELRHSVQNASYENKDPLLIYKLESYNLFKTMVDNMNRKTAAILMRGQIPVREEPTEEQRQAMQARQAAVAQQAAQAIAEERARQRIAVQEAAPEKHEDMSRYRTEKTDLSGNNTQAEAPQPKQAPVRAEKRVGRNDPCPCGSGKKYKNCHGQGL", "function": "Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.", "AFDB_id": "AF-A6L997-F1-model_v4" }, { "swissprot_id": "Q5R752", "sequence": "MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVAMSDAQDGPRVRYNPYTTRPNRRGDAWHDRDRIHVTVRRDRAPPERGGAGTSQDGTSKNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKILDRENRRISIIINPSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVSQNIDVVLNRRSCMAATLRVIEENIPELLSLNLSHNRLYRLDDMSSIVQKVPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYIRSVVACVSAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSIPFIPQNPARSSLAEYFKDSRNVKKLKDPTLRFRLLKHTRLNVVAFLNELPKTQHDVNSFVVDISAQTSTLPCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNASSEEIQRAFAMPAPTPSSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFMK", "function": "Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.", "AFDB_id": "AF-Q5R752-F1-model_v4" }, { "swissprot_id": "Q8L9T5", "sequence": "MNSNDQDPIPFRPEDNNFSGSKTYAMSGKIMLSAIVILFFVVILMVFLHLYARWYLLRARRRHLRRRSRNRRATMVFFTADPSTAATSVVASRGLDPNVIKSLPVFTFSDETHKDPIECAVCLSEFEESETGRVLPNCQHTFHVDCIDMWFHSHSTCPLCRSLVESLAGIESTAAAREREVVIAVDSDPVLVIEPSSSSGLTDEPHGSGSSQMLREDSGRKPAAIEVPRRTFSEFEDELTRRDSPASQSFRSPMSRMLSFTRMLSRDRRSASSPIAGAPPLSPTLSCRIQMTESDIERGGEESR", "function": "May be involved in the early steps of the plant defense signaling pathway.", "AFDB_id": "AF-Q8L9T5-F1-model_v4" }, { "swissprot_id": "P42296", "sequence": "MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDALKGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLSHDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLNKLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENINQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVYNTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKILETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKLINNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQIDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEKTGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGGKKK", "function": "Toxic component of one of 6 LXG toxin-immunity modules in this strain. They promote kin selection, mediate competition in biofilms, and drive spatial segregation of different strains, indicating that LXG toxins may help avoid warfare between strains in biofilms. Mediates intercellular competition during biofilm formation; disruption of the operon disadvantages the bacteria, but overexpression of the cognate immunity protein restores growth in competition with wild-type. Overexpression alone in situ causes growth arrest but not cell lysis, a large decrease in chromosomal DNA content and the production of anucleate cells. No effect is seen on rRNA. Co-overexpression with cognate immunity protein YxxD does not cause growth arrest. The toxic effect is not dependent on the epsA and tapA operons which are required for biofilm formation.", "AFDB_id": "AF-P42296-F1-model_v4" }, { "swissprot_id": "O31178", "sequence": "MTVFVDHKIEYMSLEDDAELLKTMAHPMRLKIVNELYKHKALNVTQIIQILKLPQSTVSQHLCKMRGKVLKRNRQGLEIYYSINNPKVEGIIKLLNPIQ", "function": "Represses the expression of the pagA and atxA genes.", "AFDB_id": "AF-O31178-F1-model_v4" }, { "swissprot_id": "Q8TSV8", "sequence": "MSSEMAYFSGLTDALRLTFVQIMILSTIAIVVFLYGMILNFQKWGAGVTGYALEPQAGSKGSAIRFLKTWWGQVVEESHHGHGKPILEVLILDILFQRRILKRSPLRWFMHFTIFAGWMTLFALSGLMFAVEMTEKFGIELPFTPAEFREFLSIPNYIFGYILLIGVLIALVRRIVVSDVREASIMYDWILIGGVFLVTISGFVADGIRTGIIWGFGLDPTTAPPAALFHSVISLFFCIAYIPYSKYIHVIATPLAILANKGGE", "function": "Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane.", "AFDB_id": "AF-Q8TSV8-F1-model_v4" }, { "swissprot_id": "Q9A459", "sequence": "MWIMSYRLSRKAEQDLIDIYVAGVGLFGVAQAERYQDTLEAAFGAIAAFPHIGRERPELRPPVRVHPCKSHIILYVLDERGALIVRVRHAGEDWVGEAGG", "function": "Toxic component of a type II toxin-antitoxin (TA) system. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD4 but no other ParD or RelB antitoxin.", "AFDB_id": "AF-Q9A459-F1-model_v4" }, { "swissprot_id": "Q27908", "sequence": "MYLHLTALCVVIPLCYGASMFKHDHYMDNGVRYPNGDGICKQLNETKCDAGFSYDRSICEGPHYWHTISKCFIACGIGQRQSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEPEDGENLYVKLNNLVDGHYKFHNLHVHNGRTRRKGSEHSVNGRFTPMEAHLVFHHDDQTHFEPTRTKLGGAFPGHNDFVVVGVFLEVGDDGFGDEPDDEECKHILKGHHPDNNENGNGDNGNNGYNGDNGNNGDNGNNSYNGDNGNNGVNGNNGYNGDNGNNGDNGNNGYNGDNGNNGDNGNNGENGNNGENGNNGENGHKHGCRVKKAKHLSRILECAYRNDKVREFKKVGEEEGLDVHLTPEMALPPLKYRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHALRNVEGYKDGTTLRKYGTRRPTQKNKVTVYKSFK", "function": "Acts as a negative regulator for calcification in the shells of mollusks. May function both as a calcium concentrator and as a carbonic anhydrase required for production of carbonate ions, which are assembled to CaCO(3) at mineralization sites. Is important for shell formation in both the calcitic prismatic layer and the aragonitic nacreous layer.", "AFDB_id": "AF-Q27908-F1-model_v4" }, { "swissprot_id": "Q6ALV8", "sequence": "MQKKDILFSIGWPLSSLYAGIMKLRCLLYRRGLFRQHHFPVPVISVGNLTMGGTGKTPVTHYIAKLLLEHGLQPAIISRGYSGKSGGEVNIVSDGQRILLSAEQAGDEPYMLASMLAGVIVITGKKRYLSCKYAVEKMQAEVIILDDGFQHLAVARNLDLVLFDAQTGMGNNRVFPGGDLREARFALDRADAFLITGKCPREEEELLAIELELQHELPQCPLFSVYRTEGVFYSAKQEKVVTHLPKKVFAFCGIANPERFHHDLEKQGFSLVGFKAFSDHQQYTGQCIEEIVKEAKKGGAQAIITTDKDLVKIDSFATELPLYSARPRTTISTDFDELILKTCASFGE", "function": "Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).", "AFDB_id": "AF-Q6ALV8-F1-model_v4" }, { "swissprot_id": "D4GYE1", "sequence": "MKLVAVTSCPTGIAHSQMAAENLLQAGERLGHDIDVEVQGAMGTQDELASDAIAEADAVIITSDTSVSRDRFDGKLVLKGTVKDGVNNAEAVVQKAVELAEAGKTGSVTFGSGDDGEDADVGADDSSDDADAAESDEPVRRGGDPEKGLFARLKKLFS", "function": "The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II PtfABC PTS system is involved in fructose transport.", "AFDB_id": "AF-D4GYE1-F1-model_v4" }, { "swissprot_id": "Q3USZ2", "sequence": "MTSLDNQGLWSEKDILKLLECMEHNIPSDDSREFKKSQADLNWSKVAFGLFSGEMCKQKWMEISYNLRKFRTLTELVQEAKFSFTKKTHKNKILTEHPDRPKRPLTAYLRFYKEQRAKYCQMYPKYSNAQLTKILAEKYRQLPAEIKQRYIMDFKKEKEDFQKKMRQFKKRHPVSGHPKKSVVPQSHPTKVPTKSQGDIKNVKSLVKTESPRTVSSDMKFQGEPRKPPMNAYHKFHQESWSSPELRHLSFRKRWVEISRRWHQVPENEKEHYSNQVKRLQKQYRVKLDLWLKRLSPEEYAAYKEAKATCGKRKNMSMSGGRSSKFGRTEQSSSEKGLQIKPGEVEELLDPGTDSSGTIQGHHDGAQSSRQDFTDDSEEDDSSTSSDSSSTDEDD", "function": "Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.", "AFDB_id": "AF-Q3USZ2-F1-model_v4" }, { "swissprot_id": "Q313K1", "sequence": "MAARTKNGLTASASGMQSLLPHTLPHADPAGPRDSLYPAFFTGIDEAGRGCLAGPVVAAAVILPPAGAPAAPHIAAALSGLTDSKKLSEKRRLTLEPAIKSCAVRWGVGVVWPQVIDRINILQATYRAMSLAVRHLRGGGAAASMPAGLPPVFLAVDGDKTIPGQVLQAVTGLSVPQEAIVGGDGCVMAISAASVLAKTFRDRLMTALDKRYSGYGFATHKGYGTAAHIEAIRRLGPCRMHRLSFAKVKPAAAPHAADQNTLW", "function": "Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.", "AFDB_id": "AF-Q313K1-F1-model_v4" }, { "swissprot_id": "Q8RKI8", "sequence": "MKSWFAFFYYLFIKVIGALLFWVKLGNQVTLLVSFPDNARAILKEYQKGHFSFPIHVLLTQHAKSLEKEFPELTVSVINEKHPLHICKAVFSMLNSKTVIVDNYFVLTTVLTSRPDIECIQVWHANGAFKRFGLKDINTQNRSRADIRRFRKVYASFDRIVVGSEHMADIFKEFFDIKGDTFLRFGVPLTDAYYEARENSNDLKSKYQLPAEKKIILYAPTFRDHQFESFSLPFSEKQLQHDLKGEYLLAVKLHPVMKESAELPEDSAWIKDVSDLPLADLLKMSDLLISDYSSVPFEFALLDKPILFYTYDMEAYNRTRGLIRHYTEVIPGMPCCDSGMLLDQLKDMDKLQSEVERFSREWNLYSRGNASKQLLSYVNEKSN", "function": "Catalyzes the addition of a single glycerol phosphate residue to the prenoldiphosphate-linked disaccharide.", "AFDB_id": "AF-Q8RKI8-F1-model_v4" }, { "swissprot_id": "Q9ADP7", "sequence": "MAARDPEATKARIFEAAVAEFARHGIAGARIDRIAAEARANKQLIYAYYGNKGELFASVLEKKMLDLAISVPVDPDDIEGWIDRLLDYHAAHPELLRLLFWEGMEYGTAELPHEAERQEHYARKVAAVRDGQERGVITDAIPAPDLLFLLVAMANWAVVVPQMKRILVGGGDAGTDGLRDSIKKAARRIVDR", "function": "Probably regulates the expression of its own gene and the adjacent SCO4007 gene by binding to two operator sites in the SCO4007-SCO4008 intergenic region.", "AFDB_id": "AF-Q9ADP7-F1-model_v4" }, { "swissprot_id": "O08692", "sequence": "MAGLWKTFVLVVALAVVSCEALRQLRYEEIVDRAIEAYNQGRQGRPLFRLLSATPPSSQNPATNIPLQFRIKETECTSTQERQPKDCDFLEDGEERNCTGKFFRRRQSTSLTLTCDRDCSREDTQETSFNDKQDVSEKEKFEDVPPHIRNIYEDAKYDIIGNILKNF", "function": "Acts as an inhibitor of cathepsin B (CTSB) activity. Plays a role as a negative regulator of tumor vascular development, cell invasion and metastasis.", "AFDB_id": "AF-O08692-F1-model_v4" }, { "swissprot_id": "Q10CH5", "sequence": "MAICSTDNELVELLWHNGGVVAQPQAAQARVVSSSGRGQSASVLTGDDTETAAWFPDTLDDALEKDLYTQLWRSVTGDAFPAAAAAGPSSHHAPPPDLPPPAARPPMRSGIGSSWTGDICSAFCGSNHIPETAAQRCRDAGAALPPERPRRSSTHDGAGTSSSGGSGSNFGASGLPSESASAHKRKGREDSDSRSEDAECEATEETKSSSRRYGSKRRTRAAEVHNLSERRRRDRINEKMRALQELIPHCNKTDKASILDEAIEYLKSLQMQVQIMWMTTGMAPMMFPGAHQFMPPMAVGMNSACMPAAQGLSHMSRLPYMNHSMPNHIPLNSSPAMNPMNVANQMQNIQLREASNPFLHPDGWQTVPPQVSGPYASGPQVAQQNQIPKASASTVLPNSGAEQPPTSDGI", "function": "Transcription factor that may act as negative regulator of phyB-dependent light signal transduction. Transcription activator that acts as positive regulator of internode elongation. May function via regulation of cell wall-related genes. May play a role in a drought-associated growth-restriction mechanism in response to drought stress.", "AFDB_id": "AF-Q10CH5-F1-model_v4" }, { "swissprot_id": "O53509", "sequence": "MPGRAPGSTLARVGSIPAGDDVLDPDEPTYDLPRVAELLGVPVSKVAQQLREGHLVAVRRAGGVVIPQVFFTNSGQVVKSLPGLLTILHDGGYRDTEIMRWLFTPDPSLTITRDGSRDAVSNARPVDALHAHQAREVVRRAQAMAY", "function": "Binds DNA at low salt concentrations.", "AFDB_id": "AF-O53509-F1-model_v4" }, { "swissprot_id": "P30847", "sequence": "MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV", "function": "Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons.", "AFDB_id": "AF-P30847-F1-model_v4" }, { "swissprot_id": "Q63688", "sequence": "ALEYQYVMKNPKQLSFEKFSRRLSAKAFSVKKLLTNDDLSNDIHRGYLLLQGKSLDGLLETMIQEVKEIFESRLLKLTDWNTARVFDFCSSLVFEITFTTIYGKILAANKKQIISELRDDFLKFDDHFPYLVSDIPIQLLRNAEFMQKKIIKCLTPEKVAQMQRRSEIVQERQEMLKKYYGHEEFEIGAHHLGLLWASLANTIPAMFWAMYYLLQHPEAMEVLRDEIDSFLQSTGQKKGPGISVHFTREQLDSLVCLESAILEVLRLCSYSSIIREVQEDMDFSSESRSYRLRKGDFVAVFPPMIHNDPEVFDAPKDFRFDRFVEDGKKKTTFFKGGKKLKSYIIPFGLGTSKCPGRYFAINEMKLLVIILLTYFDLEVIDTKPIGLNHSRMFLGIQHPDSDISFRYKAKSWRS", "function": "Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol. Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.", "AFDB_id": "AF-Q63688-F1-model_v4" }, { "swissprot_id": "Q53TZ2", "sequence": "MSDQVSLGVVGIGKIARDQHLPAIDAEPGFKLTACASRHAEVTGVRNYRDLRALLAAERELDAVSLCAPPQVRYAQARAALEAGKHVMLEKPPGATLGEVAVLEALARERGLTLFATWHSRCASAVEPAREWLATRAIRAVQVRWKEDVRRWHPGQQWIWEPGGLGVFDPGINALSIVTRILPRELVLREATLIVPSDVQTPIAAELDCADTDGVPVRAEFDWRHGPVEQWEIAVDTADGVLAISRGGAQLSIAGEPVELGPEREYPALYAHFHALIARGESDVDVRPLRLVADAFLFGRRVQTDAFGR", "function": "Catalyzes the NAD(P)(+)-dependent conversion of L-arabinose to L-arabino-gamma-lactone. Is involved in a degradation pathway of L-arabinose that allows A.brasilense to grow on L-arabinose as a sole carbon source. Prefers NADP(+) to NAD(+) as electron acceptor. Displays high catalytic efficiency for both L-arabinose and D-galactose in vitro. However, the enzyme appears to be involved in the metabolism of L-arabinose but not D-galactose in vivo. To a lesser extent, is also active on D-talose and D-xylose as substrates in vitro, but not with D-arabinose, D-glucose, D-ribose, L-xylose, L-mannose, L-lyxose, and D-fructose.", "AFDB_id": "AF-Q53TZ2-F1-model_v4" }, { "swissprot_id": "Q96IQ9", "sequence": "MEEKPSGPIPDMLATAEPSSSETDKEVLSPAVPAAAPSSSMSEEPGPEQAATPPVWERGGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPRRRPPPGKQIPCSSPGCCLSFPSVRDLAQHLRTHCPPTQSLEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRSLFKHLHVCAEHAQSPAPPPPPALDREPPAPERPPEVDPASAPGLPFPLLEPFTTPAPAPTGPFLPYLNPAPFGLSPPRLRPFLAAAPGPPASSAAVWKKSQGAGSSPRRPQGGSDAPSGACR", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q96IQ9-F1-model_v4" }, { "swissprot_id": "Q553K4", "sequence": "MNNNNNNKKLNKENLNEIENWNEIELTDYKKQGLDEGTSSNIYLFESNGNVVNGSIEDSPKQQQQQQQQQQQQQQQQQQQQQQQQNIISSDEEIEDKPFQDRDSNIGDGSDIDSSGDSIDIENTDYSILVPFEDEENNNGSKSKFSIKKLKSFLGPALFISVGYMDPGNWATDLEGGSRFGYQLMWVLLFSNIMALFLQTLVIKLALVTKNDLAQQCRKEYSKTVNIFLWLILELAIISTDLAEVIGTAIGLNILFGLPLIAGVAITSLDTLLFLAIQRWGIRKLELLILLLLSMITMCFVIELFLSKPIASEVFSGFVPRLNSDSVMVATGIVGATTMPHNLFLHGSVVKSRKIPNDRRKSVIKQAYRYNVIDTVLALNCAFFVNIAILMLAASVFWKSNIQVTELSEAYRLLTKLMDGKLAAVLFGLGLFLAGQSSTITGTMAGQIVMEGFIKLRIKPWLRRFITRLLAIIPAAIVIIVLGDKGTYTLLIISQVLLSIGLPFAVVPLIIFTSSYEIMGEFKNRLSIIIINSIIALFIIGLNLATIFQLINDFLHNDSIISKCLTIIFLIPLSIALCCLLLWLIISKINFFTNLLSKIFNNNNNNNNKNIINNNNNYSGNTINNQTIQ", "function": "Divalent transition metal (iron and manganese) transporter.", "AFDB_id": "AF-Q553K4-F1-model_v4" }, { "swissprot_id": "C1J5M7", "sequence": "MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDLSSEQHPLFEKRIVDRCCNKGNGKRGCSRWCRDHSRCCGRR", "function": "Mu-conotoxins block voltage-gated sodium channels. Extremely potent inhibitor of Nav1.4/SCN4A (96% inhibition at 1 uM). The inhibition is very slowly reversible.", "AFDB_id": "AF-C1J5M7-F1-model_v4" }, { "swissprot_id": "Q2LPW5", "sequence": "MPNRGAHFSISRRKDFLMDFSERVFCGHLTPDHTGRRVLLAGWVDAFRDHGGLLFIHLRDRNGIIQIVFSPEAASADVYRQAASLRAEYCVAVQGEVRKRLPGTENPHIETGDIEVFVSELTVLSESEALPFAISDKAMVAGASSAGADHVNEDLRMQYRYLDIRRPAMQKNLILRHRISQCVREFLDSRGFVEVETPVLTMSTPEGARDYLVPSRIHPRSFYALPQSPQLFKQLLMIGGMERYFQLARCFRDEDLRPNRQPEFTQLDIEASFIDEEFLYELIEELTVRMFAIGGIALSRPFPRMTYAEAMDTTGSDRPDLRFGLRMADVTGVFSRTSYSIFKQILQRGGSIKGINIKGQSEKLSKNVLQNEYAKEIAPSFGAKGMTWMRAEEGKLESNIVQFFSADELEALKRVFQVEDGDVLIMVADPSCAIVNSALGQLRLHLGNRLGLIPEGVFYPVWITEFPLFEPTDEGGVTSSHHPFTAPDRTDFDPGNIEELLSLRSRAYDLVVNGEELGGGSIRINDREVQRRIFAALGLTEEDVKNKFGFFLRAFDFAAPPHGGLALGMDRVVSMILQTPSIREVIAFPKNRSAACPLTGAPSEVKREQLAELGLLNLGDKDVLPGDAEKEDRIDHLSWVSRIGIAEGERPVMESILAQAEELAAQVGDLAGNEEPVRSVAPVANRVREGLEAVRLSFSGTGRLLKNAPAVKGDYFKVAGILD", "function": "Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).", "AFDB_id": "AF-Q2LPW5-F1-model_v4" }, { "swissprot_id": "Q4R6M4", "sequence": "MTTLPPLPMTRPKLTALARQKLPCSSRKIPRSQLIKEKDDIDHYLEVNFKGLSKEEVAAYRNSYKKNICVDMLRDGYHKSFTELFALMEQWDALREAARVRSLFWLQKPLEEQPDKLDYFYHYLTRAEDAERKKSFEDVYNNLYALACYFNNPEDKWVRNHFYERCFKIAQLIKIDGGKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRIWKDETGRSLNLLACESLLRTYRLLSDKMLQNKEYKQAIKILIKASEIAKEGSDKKMEGEASYYLGLAHLAAEEYETALTVLDTYCKISTELDDDLSLGRAYEAIAKVLQSQGNTTEAIKYLKKFVKIARNNFQSLDFVRASTMLGDIYNEKGHYNKASQRFQQAFDTTVELMSMPLMDETKVHYGIAKAHQMMLTVNNYIESADLTSLNYLLSWKESRGDIEPDPVTEEFRGSTVETVSQNSEHLEELSRFPGDQKNET", "function": "Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility.", "AFDB_id": "AF-Q4R6M4-F1-model_v4" }, { "swissprot_id": "A0A348AXX8", "sequence": "MTFVETVAVPDNEERPSAGHNRPVADSTKCPNAREMKVQNRVAQRTHHRRLKTKLEVLRERLKEPEKQVGEPARVQTSTSTLVSDAATSLADSMCLVPAVQNDQAMAFDFLMTPSPSVGNDCPSNDLETMRQAASVHSNTLGGAFPLNRSPCTENMTPESQVSLSTAPLCFTSVVPAELDMDAFCTLDSSDWSRPNEESLLRLANYSTSVSPTNVQWGVDENAPLQDRVRYMRDQAVAMGFGSLDDVVEAHYTQKLECTSPSFQEQRLSRNRRLSRLLSTLHNAAKDWSEWERRGLQEQVTQGAEDILVSELNSYITQRSMNSTDDKIITGGLLDEQSRLRQDVEERRRLQDSLPNLGALLTTLLSRSNAPNQDARRDTVLAMIKTMCFDQDENMSIS", "function": "Transcription factor that positively regulates the expression of the gene clusters that mediate the biosynthesis of KK-1, a novel cyclic decapeptide compound with potent antifungal activity.", "AFDB_id": "AF-A0A348AXX8-F1-model_v4" }, { "swissprot_id": "G8SD34", "sequence": "MRYDAFISYSHAADGALAPAVQRGLQRLARRWHRPRALEVFRDQTGLAVSHALWSSIKVALDQSEFFVLLASPEAAASPWVNQEIEHWLSRHSVDRLLPVVTSGEWVWDADAGDVDLERSTAVPPALRGVFGEEPRHLDLRWARAEHELDLRHGRFRDAIAELAAGMHGMSKEDLDGEDVIRHRQMLRMRRGALAVVCALLLLVAGTAVAWRNARGEVTATNVALQRQRAATAAEQHRTEEAADQARSQQQIVEAEQQRAQKAAEEARGQQAVAEAEQQRALRAAGEARRQEGIAAAEQRRAQKAAAEARRQRGVADAEKAKANRAAAEAERQRKIAADEQRKAHEAAAEAERQREEAVKQQRIAIGRRLLGQAGEARDRDPRTAIQLGIAARHIYPGPQSQAGLVETLVRTHYAGTVTGHTAVVSAVALSGDGRTLVTDGLDGTVMVWDPTDRAAPRRLAQLTSSTAPVYTVALSGDGRTLVTGSEDGTAMVWDLTDRAAPRRLAQLTGHTDVVDAVALSGDGRTLATGSFDGTAMVWDVTDRAAPRRLAQLTDHTAPVTAVALSGDGRTLATGSDDHTAMVWDLTDRAAPRRLAQLTGHTAGVDAVALSGDGRTLATGSYDGTAMLWDLTDRAAPRRLAQLTGHTAQVYTVALSRDGRTLATGSEDHTAMVWDLTDRAAPRRLAQLTGHTDAVDAVALSGDGRTLATAASITRRCCGM", "function": "NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide.", "AFDB_id": "AF-G8SD34-F1-model_v4" }, { "swissprot_id": "K0E690", "sequence": "MLATDSTPALLAASVVLAVSLVSYVIQLNRSRTHRAFWASHPWVGVRDEWFSGARTKLRIVTSVREMVEDGFHRFSQFKTAFALPNIGEPPWLVLPPASLREFLAKPDADLDHNIIHEEQLQNYYTQGALGHHAATIPLQFDVVRRQLTRELPLVAAALHDELHKSFQDYWGTDTIAAKQIDLLATCFKIVTRTANRVFIGADICRSEAFLEHLRRYSDAVGRAGIIIRLFPRWLRPVVTPAVTVWYRRDLAVCREICVPVIRCRVQQTIEKRKDVDCTWKAPVDVLQWLIEAALRRNDAAELDPLLLTQRLLMLNFVSIETTSMAITHAIADLYGSADADSFIAGLQEECERALPHGELWTKAQLDNLVRIDSAIRESMRVSDFSHIQLPRLVANPHGVDFQSTGNPPLHVPPGIRLCVPAHSIHRDPALYPDPLTYNAFRFVIEPSVGAGDATEPAPKQASLATTTDSFLVFGHGRHACPGRFFAAHLMKLMLAYIVRHYDVARLTQPVDKQTTECTKAPFHMEYGGGPLAYMGHSLTGATRLQDTLCFMKFDSSQYLDTSPIVTIPSYIYWPSLNTMNQSSKYSLYVFVVLVACVAALFIGIGIYQMYHPLDRDNAAYREVPHEQRAYMRKAGSPPAFSKFIYRLYCPNIQWKVKRCIGVLFLLFAYYNSRLRLSSATKN", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the de novo generation of L-homotyrosine from acetyl-CoA and 4-hydroxyphenyl-pyruvate. L-homotyrosine is a building block of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent. L-homotyrosine 4-hydroxyphenyl-pyruvate first undergoes an aldol-type condensation by htyA with the C-2 of acetyl-CoA followed by the release of CoA to form 2-(4-hydroxybenzyl)-malate. This is followed by isomerization of 2-(4-hydroxy-benzyl)-malate to 3-(4-hydroxybenzyl)-malate by htyD. Thereafter, 3-(4-hydroxybenzyl)-malate undergoes decarboxylation and oxidation to form 2-oxo-4-(4-hydroxybenzyl)butanoic acid, coupled to reduction of NAD(+) to NADH by htyC. The product then undergoes transamination catalyzed by htyB to form L-homotyrosine.", "AFDB_id": "AF-K0E690-F1-model_v4" }, { "swissprot_id": "P19334", "sequence": "MGSNTESDAEKALGSRLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAVDRSKSTFTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKMLRKTLGRKRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYITAEQRRRDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQEMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASDPIGSKRSSMQRHSQRSLRRKIIEQANEGLQMNQTQLIEFNPNLGDVTRATRVAYVKFMRKKMAADEVSLADDEGAPNGEGEKKPLDASGSKKSITSGGTGGGASMLAAAALRASVKNVDEKSGADGKPGTMGKPTDDKKAGDDKDKQQPPKDSKPSAGGPKPGDQKPTPGAGAPKPQAAGTISKPGESQKKDAPAPPTKPGDTKPAAPKPGESAKPEAAAKKEESSKTEASKPAATNGAAKSAAPSAPSDAKPDSKLKPGAAGAPEATKATNGASKPDEKKSGPEEPKKAAGDSKPGDDAKDKDKKPGDDKDKKPGDDKDKKPADNNDKKPADDKDKKPGDDKDKKPGDDKDKKPSDDKDKKPADDKDKKPAAAPLKPAIKVGQSSAAAGGERGKSTVTGRMISGWL", "function": "A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development.", "AFDB_id": "AF-P19334-F1-model_v4" }, { "swissprot_id": "Q54JB3", "sequence": "MMLSKIINNISKSGLRNTTNSKNGGLLYFQNYYMKSSTTITRLNSGNNNYSNNNNNNNNIILNDKFLNKQQNDKKIIYNNIFEEKNQFLKRIYSTSTTTTSTTTTTNINENNIKNENNNENNNENSNNNNEQSIKSNQTKSKGFLRGPYMTLIKLPITVYVTLTAIAGYVAACPIGAFDWVVLSQVSIGTFLASCSANIHNQEIEVQHDRKMPRTKDRPLVIGTINRGKAWVGSIALLTLGFGTMAVTPSLFVPGTLAACNVILYCWYTDLKRVTPLNTWIGAFVGAIPPLIGSVAATGEFEAIGMLLATFMYIWQIPHFLALSQVLREQYRGAGYKMLSVTHEKKTVDRVSLAHALFGIPLPFIFDYFFNFNVHPITLTCMALSSASLALPFITKISPKRLYIISLISLPITLFLSCLLRQPFAYYTDDDDEDKDKDNQNQIENQDKK", "function": "Converts protoheme IX and farnesyl diphosphate to heme O.", "AFDB_id": "AF-Q54JB3-F1-model_v4" }, { "swissprot_id": "Q8EX12", "sequence": "MNDNNNNNEFKPENLESLNNTEFHISIKDITGKEFNGPFELFYSLIKERKMDILNINLVEVIQLYVDYINNYLTKLKIDDLTEYLLMATYLLEQKSKRILPSMDTEEKISKDIERDKYIQRLLVYKQYQEIVPKLMEKLERRSRMFEKPTQSGEDKESLLKEFQDNSYVPAMDLDVILKAMQKVYLKLVTTKKTKSPKDNVKLIDVSEISIDDVEKEIREFLEPFPHLYKISFMDYFKNIPDEKFTKRYFVVAFVAILVLVRNGHIQLEQNSSDENIFIVKIDKEVESNEY", "function": "Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.", "AFDB_id": "AF-Q8EX12-F1-model_v4" }, { "swissprot_id": "F7ZKE9", "sequence": "MPDILTASQMRALETAAFNSGAVTGLELMERAGQSVIDALFSSKAELATGEHRAVILCGPGNNGGDGFVIARLLFVLGWQVRVYLYADPEKMPRDAHANHDSWVDLVPECTQRISFPSVLPAEAERFGDEAFGNGEVDVIVDALFGIGLNRPLSGLHPILATCHANRHEAYFVAVDVPSGLGENGPLEAADWSVFPADLTVTFHRPKQAHQNGLSFCGKIMVQYIGL", "function": "Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.", "AFDB_id": "AF-F7ZKE9-F1-model_v4" }, { "swissprot_id": "Q9HCM1", "sequence": "MNWNEKPKSATLPPLYPKSQPPFLHQSLINQITTTSQSSFSYPGSNQEACMYPGNSNPISQPLLNIQNYPQQISVSDMHNGTVVASHTSVERITYANVNGPKQLTHNLQMSSGVTQNVWLNSPMRNPVHSHIGATVSHQTDFGANVPNMPALQSQLITSDTYSMQMQMIPSNSTRLPVAYQGNQGLNQSFSEQQVDWTQQCISKGLTYPDYRPPPKLYRYSPQSFLPDSTIQKQNFIPHTSLQVKNSQLLNSVLTLPSRQTSAVPSQQYATQTDKRPPPPPYNCRYGSQPLQSTQHITKHLSMEVPQSREMLSSEIRTSFQQQWQNPNENVSTIGNFTNLKVNTNSKQPFNSPIRSSVDGVQTLAQTNEEKIMDSCNPTSNQVLDTSVAKEKLVRDIKTLVEIKQKFSELARKIKINKDLLMAAGCIKMTNTSYSEPAQNSKLSLKQTAKIQSGPQITPVMPENAERQTPTVVESAETNKTQCMLNSDIQEVNCRRFNQVDSVLPNPVYSEKRPMPDSSHDVKVLTSKTSAVEMTQAVLNTQLSSENVTKVEQNSPAVCETISVPKSMSTEEYKSKIQNENMLLLALLSQARKTQKTVLKDANQTIQDSKPDSCEMNPNTQMTGNQLNLKNMETPSTSNVSGRVLDNSFCSGQESSTKGMPAKSDSSCSMEVLATCLSLWKKQPSDTAKEKECDKLRTNTTAVGISKPANIHVKSPCSVVGNSNSQNKISNPSQQTALSMVMHNYESSGINITKGTELQIAVVSPLVLSEVKTLSVKGITPAVLPETVYPVIKEGSVCSLQNQLAENAKATAALKVDVSGPVASTATSTKIFPLTQKEKQNESTNGNSEVTPNVNQGKHNKLESAIHSPMNDQQISQESRNSTVVSSDTLQIDNICSLVEGDTSYNSQIAKIFSSLPLKMVEPQKPSLPNQQGIGSREPEKQLDNTTENKDFGFQKDKPVQCTDVSHKICDQSKSEPPLESSFNNLETNRVILEKSSLEHATEKSTANDTCSSAAIQEDIYPQEIDASSNYTPQDPARNEIHSDKAPVLYLHDQLSELLKEFPYGIEAVNTREGSVGQQTTYQTSEDQTADKTSSDSKDPADQIQITILSSEQMKEIFPEQDDQPYVVDKLAEPQKEEPITEVVSQCDLQAPAAGQSRDSVILDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSSSEEEKQKEQCSPLDTNSCKQGERTSDRDVTVVQFKSLVNNPKTPPDGKSHFPELQDDSRKDTPKTKHKSLPRTEQELVAGQFSSKCDKLNPLQNHKRKKLRFHEVTFHSSNKMTASYEQASQETRQKKHVTQNSRPLKTKTAFLPNKDVYKKHSSLGQSLSPEKIKLKLKSVSFKQKRKLDQGNVLDMEVKKKKHDKQEQKGSVGATFKLGDSLSNPNERAIVKEKMVSNTKSVDTKASSSKFSRILTPKEYLQRQKHKEALSNKASKKICVKNVPCDSEHMRPSKLAVQVESCGKSNEKHSSGVQTSKESLNGLTSHGKNLKIHHSQESKTYNILRNVKEKVGGKQPDKIWIDKTKLDKLTNISNEAQFSQMPPQVKDQKKLYLNRVGFKCTERESISLTKLESSPRKLHKDKRQENKHKTFLPVKGNTEKSNMLEFKLCPDILLKNTNSVEERKDVKPHPRKEQAPLQVSGIKSTKEDWLKFVATKKRTQKDSQERDNVNSRLSKRSFSADGFEMLQNPVKDSKEMFQTYKQMYLEKRSRSLGSSPVK", "function": "Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.", "AFDB_id": "AF-Q9HCM1-F1-model_v4" }, { "swissprot_id": "Q99089", "sequence": "MGNTDDVKAVKPEKLSSPPPPAAPDQSNSHVYPDWAAMQAYYGPRVALPPYFNPAVASGQSPHPYMWGPPQPVMPPYGVPYAALYAHGGVYAHPGVPLAASPMSMDTHAKSSGTNEHGLIKKLKGHDDLAMSIGNGKADSSEGEMERTLSQSKETEGSSDGSNENSKRAAVNGRKRGRDEAPNMIGEVKIETQSSVIPSPRAKSEKLLGITVATPMVAGKVVGTVVSPSMTSSLELKDSPKEHAVNSPAGGQQPSTMMPNDSWLHNDRDLKRERRKQSNRESARRSRLRKQAEAEELAIKVDSLTAENMALKAEINRLTLTAEKLTNDNSRLLEVMKNAQAERAADVGLGNNNEKKASTLSTANLLSRVDNAGSGDRDEGESDVYEKTTKSGAKLHQLLDANPRTDAVAAG", "function": "Binds to the G-box-like motif (5'-ACGTGGC-3') of the chalcone synthase (CHS) gene promoter. G-box and G-box-like motifs are defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control.", "AFDB_id": "AF-Q99089-F1-model_v4" }, { "swissprot_id": "A2ARK0", "sequence": "MQGCQAGASIFFLIAANPDANHGASGGLGSRWIRTFSRIAPAGTQGMAGPLRSRVEELKRPWWRESSPLVLQHSEAARLAADALLERGEAAYLQVISEERELPFLSALDVDYMISHVRGVPELSEAQGSETLGQDLSMLSEVTSGTYFPMASDLDPPDLDLGWPEVPQATGFSPTQAVVHFQRDKGKSIKDLLRFLFSQAQTVVAVVMDVFTDMELLCDLMEASSRRGVPVYLLLAQEHLKYFLEMCYKMDLNGGHLVNMRVRSTCGDTYCSKAGRRFTGQALEKFVIIDCEQVVAGSYSFTWLCSQAHTSMVLQLRGHIVEDFDREFRCLYAESQPVEGFCSNEDPLMPQVPRPPPVTLAFGPAVPSATGSSPSSNSLSSIKHSPLLARSSYLALPGGGGRNDMGMGSSSPGPAYHEAGGQPSLYRQLSDPNHISPPGPYRANLSKLGASPWSQSSPALNHSSTSPLTLAVGSPLLPSSRPLLHFTRGVPALSRLPENGLPASQDPSLPRGRWVPGTALETVEEKKVSLSQSHDHLDRLSPFSKAGEAGGPNSRVTPDSSSLQHRELALDDRRLSLSHSHSQLDLLSQGQGVLESGSLRPGELSLENRKLSLNHNHGQLDLLPQNPKPQAPKIPSDAYSSAGPSKPSLDDRRQTLGHSQLDLITKFGPFRSEGPGPSCPPEPSPVRMAGVGSADEKRLTLGHSKLDLITKYHQLQGARQKPEPGIPGAPVSGHQNGSSNDLFAPEKRLTLGHSKLDLITKYNKSKFKQLRSRFES", "function": "May play a role in MAPK signaling.", "AFDB_id": "AF-A2ARK0-F1-model_v4" }, { "swissprot_id": "Q99S97", "sequence": "MRLKSIITVIALILIMFMSAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLSRFKIIYVAIAGLLLFSIGSFMCGLSTNFTMLIISRVIQGFGSGVLMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVIWTFHFPEEETVAKSKFDTKGLTLFYVFIGLIMFALLNQQLLLLNFLSFILAIVVAMCLFKVEKHVSSPFLPVVEFNRSITLVFITDLLTAICLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHRIEAKLSRKVIYLLSFTLLLVSSIIISFGIKLPVLIAFVLILAGLSFGYIYTKDSVIVQEETSPLQMKKMMSFYGLTKNLGASIGSTIMGYLYAIQSGIFGPNLHNVLSAVAVISIGLIVLWVVFFKEQSSQSKE", "function": "Energy-dependent drug efflux pump that increases resistance to antimicrobial agents such as norfloxacin, acriflavine and ethidium bromide.", "AFDB_id": "AF-Q99S97-F1-model_v4" }, { "swissprot_id": "P20074", "sequence": "MDAPIPTPAPIDLDTWPRRQHFDHYRRRVPCTYAMTVEVDVTAFAAALRRSPRKSYLAQVWALATVVNRHEEFRMCLNSSGDPAVWPVVHPAFTVFNPERETFACLWAPYDPDFGTFHDTAAPLLAEHSRATDFFPQGNPPPNAFDVSSLPWVSFTGFTLDIRDGWDHLAPIFTLGRYTERDTRLLLPLSVQIHHAAADGFHTARLTNELQTLLADPAWL", "function": "This enzyme is an effector of chloramphenicol resistance in bacteria.", "AFDB_id": "AF-P20074-F1-model_v4" }, { "swissprot_id": "Q6LY59", "sequence": "MMAKPKKTIPAKLSDERIVIYDKDGISRLNEKRYGELHENFLSLSFVEGLYLVSKNWISLRDKNKKLLSFEELFDVAQNIDRKLCIRYLAYKDLRNRGYTVRTGLKYGSDFRLYERSNIDEIHSRYLVKVFSEEIPCEISEITGFVRVAHSVRKELIIAIVDADGSVVYYNMGYLKL", "function": "Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.", "AFDB_id": "AF-Q6LY59-F1-model_v4" }, { "swissprot_id": "P13800", "sequence": "MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARIVEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARGYLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIRRPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVVVAIKNGWVEMR", "function": "Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. Involved in the control of expression of different cellular functions, including production of degradative enzymes such as the neutral and alkaline proteases, flagellum formation, biofilm formation, and competence for DNA uptake. Positively or negatively regulates expression of many different genes. The phosphorylated form is required for synthesis of degradative enzymes, flagellum formation and biofilm formation. The unphosphorylated form is required for expression of genetic competence, via induction of comK.", "AFDB_id": "AF-P13800-F1-model_v4" }, { "swissprot_id": "Q9ZWD1", "sequence": "MLAPGESVLIPAEEISLSAGDVISLSVHNLIASVSSYRPWWSEFLAFGSIDRPSSFSPAVSRVKLNLHHFAVNYVLLTAASITLFLIGDPMALVTVASFVAMWLLLYFYRDHPLVLYGRHISDRVIVFGLILGSLWALWFINSLQCLILGVVTSVLLCLVHAIIRNSDDLFVQEKDVVVPSNFLHWS", "function": "May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.", "AFDB_id": "AF-Q9ZWD1-F1-model_v4" }, { "swissprot_id": "G3F5K2", "sequence": "MPHSIDMEDSSAIAERSKHAGLALEPEACFNLPQPTAEDRQDNWQTQYHSSEGAQGGSRKAQAADATTGNPTVDDASQQNGLLQQWVKQGYFMPAEHGSKAGNDVKHKYSPPKSDVWGVLVACTVITTWAALFYHSIFQIKLPSIEQLRSGNYNPSDFTSWPHVLLAFFSLEFLYTGLFITTHDAMHGTIAMRHRKLNDFLGSFAISLYAWFDYKMLHKKHWEHHNHTGKVGADPDFHRGNPSILPWFARFMMEYSSLWQFAKIAWWATGMQLLGAPFQNILMFMTAAPILSAFRLFYYGTYIPHHPEPGPASDKVEMDWTMSRTSTAPSLLSFLTCYHFDLHWEHHRWPYAPWWQLPVCRKLAGRTNPLHTEALQTAEPSRLEHGG", "function": "Involved in the biosynthesis of ketocarotenoids which are powerful anti-oxidative molecules. Catalyzes the conversion of beta-carotene to canthaxanthin via echinenone.", "AFDB_id": "AF-G3F5K2-F1-model_v4" }, { "swissprot_id": "Q66KF6", "sequence": "MADACSEMDRGAEKYPLLGFGQAVIGPPGSGKSTYVRAMQALLARMGRKSAIINLDPAGEDEPGAAVSLRELLGLEEVMSELRLGPNGSLLYCMEYLQENLDWLRARLQGLRGTYLLLDCPGQVELYTHHPALPDILRRLGGWGLRLCAVHLVDSHYCTDPAKFISVLCTSLSTMLHVELPHINVLSKMDLIEQYGRLAFNLDYYTEVMDLSFLVEQLTSDPFFRRHKRLHEKLAGVIEDYGLVTFMPLSIKDDKSLQLVLSAVDKASGFCFGEAKQSLGNLMSVAVGADFQFTSTLAFQEKYVENDGRTVEEETLDL", "function": "Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.", "AFDB_id": "AF-Q66KF6-F1-model_v4" }, { "swissprot_id": "Q8I1F0", "sequence": "MPSYMAFTPYIMFSTNYAAIAYILISRCYRDSMLLDLQRITLEVNREMLRTGKKMNSLIRRMFFLKTFTLTYSCLSYILAVLVYQWRAQNWSNLFNGLLVNISLTILVVTTFFYFVSLMHVARGFDFVNQQLEDIVSSQSMDLKKKAHELRSLWALHSNLSNTARRINKHYGPQMLALRFDYFIFSVINCCIGTIYSNSDQESSFEKFFGSLLYWARSVDFFLNDYICNLVTEYQSQPKFFAPEGSMTNELSSYLIYESSTRLDLLVCGLYPVNKAKWLEMVASIVVHSIMLFQFHLVMRGGYTTLFSRTYALLANIITLTMLPIVMWQVRSVFLAKRHYPQLILITNDIRYTVSFLIILYTLLSRGFRDTALKEMQPLLLTLFREEKRCGYKGIDGVRRSLRILLFVKFFTLSWLCITDIIFLFYSSDAVIWVNIARFLFLSNTNNILEMVPMGYFLALWHIARGFDCVNRRLDQIVKSKSTRDQKELQHLWFLHTCLTKTALNINKIYAPQMLATRFDHFVIGVIQAYWGAVFTFDLSTSFLWVVYGSVQYHVRSLDYYLIDYMCDVAVEYHDSARHSWSEKECY", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.", "AFDB_id": "AF-Q8I1F0-F1-model_v4" }, { "swissprot_id": "Q8SRP6", "sequence": "MHLGMLKKRIGISILDCNFGNLEEELGELKRNGVTNIHLDVMDTTFVKNITFGPCIINRILEHDFVFDVHMMVESPLDIIMQIDLERVSLVTIHSEVCDKAGVAEYLRKRNVLFGIALNPETQVDDAEMRSADFVLIMSVKPGFGGQKFQEECLAKVEEVRRYGKMVGIDGGIEMSNIGRITGADYAVVGSGYFRSGDRKKFLRDITDEFLCGSCSG", "function": "Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.", "AFDB_id": "AF-Q8SRP6-F1-model_v4" }, { "swissprot_id": "P15698", "sequence": "MKKFIKILKVLSMAIVLSACNINGIFASNLNTTNEPQKTTVFNKNDNTWNAQYFRIPSLQTLADGTMLAFSDIRYNGAEDHAYIDIGAAKSTDNGQTWDYKTVMENDRIDSTFSRVMDSTTVVTDTGRIILIAGSWNKNGNWASSTTSLRSDWSVQMVYSDDNGETWSDKVDLTTNKARIKNQPSNTIGWLAGVGSGIVMSDGTIVMPIQIALRENNANNYYSSVIYSKDNGETWTMGNKVPDPKTSENMVIELDGALIMSSRNDGKNYRASYISYDMGSTWEVYDPLHNKISTGNGSGCQGSFIKVTAKDGHRLGFISAPKNTKGGYVRDNITVYMIDFDDLSKGIRELCSPYPEDGNSSGGGYSCLSFNDGKLSILYEANGNIEYKDLTDYYLSIENNKKLK", "function": "Sialidases have been suggested to be pathogenic factors in microbial infections.", "AFDB_id": "AF-P15698-F1-model_v4" }, { "swissprot_id": "Q5R0V3", "sequence": "MSTLLHIDSSVRAVSNTNPDHNSISKSIALRFIETWKQHRPQDEYIYRDVGVNPPDFINQDWVGAVFTPDDKRTPEQKERLALSDKLIDEVSAADVIVISSPMYNYGMPAQLKAWFDQIVRINKTFDFDLSRGDFPLQPILSGKTLITVTSSGEFGFEKGGVREGSGHLAPHLRTLSKYLGVDTMYEIVSEYQEFGDDRHRVSVANAKDRAECLASELSLSTTDSLLKSDSVGSDLGITP", "function": "Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.", "AFDB_id": "AF-Q5R0V3-F1-model_v4" }, { "swissprot_id": "O05516", "sequence": "MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVHSLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAANGRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLFLGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLAEAEAKWIESQK", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE; this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.", "AFDB_id": "AF-O05516-F1-model_v4" }, { "swissprot_id": "Q45975", "sequence": "MNAFATAFQVYVAALVFARVGAMVMTMPGIGDQAIPARIRLSFALLMALILAPLVQNTVGPIPSTLGGLGGAVIHEVLIGLMIGSVLRLFMTSLTTAGEIISMQTTLSFAQSTNPSMEGSSTAVATFLSMLGLTLVMATDLHHLFIAAIVKSYTIFPFTRAVPVNDAAALAVQTVAQSFSLGVQLAAPVIVFSLVFNLATGLVGRIMPAFQIFFVASPLSVILGLSLLALSLSGIAMVWTDRYRELLDIFT", "function": "Role in flagellar biosynthesis.", "AFDB_id": "AF-Q45975-F1-model_v4" }, { "swissprot_id": "Q7NL83", "sequence": "MARAYRLGEDLGTGAKCVKFLINLASTPSMAVVPTAVELCIQAAVDDPVGEARWQSWFDQWLLELQSAGAVELTLRLTDDAEIRRLNARFRGVDAPTDVLSFEFEADDTQALIAEEPLYLGDIVVSVPTATRQAREFGHTLEVELAWLAVHGLLHLLGWDHPDEQSWRAMVTQQARLLKGVNVVYDWPSVYPVG", "function": "Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.", "AFDB_id": "AF-Q7NL83-F1-model_v4" }, { "swissprot_id": "P39083", "sequence": "MASTAPNEQFPSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGALICFDCSDSCKNCGKKIDDLAIILSSSNEAYCSDCFKCCKCGENIADLRYAKTKRGLFCLSCHEKLLAKRKYYEEKKRRLKKNLPSLPTPVIDNGHTDEVSASAVLPEKTFSRPASLVNEIPSGSEPSKDIETNSSDIVPHFITGYNDSDDNSGSSKFGSNVSIDVIGPEENSTEHVNDDVKEEAEAPSANMSLNVATDPTLSCKEPPSHSRNLLNKTPLRNSSGQYLAKSPSSYRQGIIVNDSLEESDQIDPPNNSSRNASELLTSVLHSPVSVNMKNPKGSNTDIFNTGEISQMDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQEQAEKYSYSNNSGKGRKISRSLSRRSKDLMINLKSRATGKQDSNVKLSPASKVTSRRSQDLMRDNDSHTGLDTPNSNSTSLDILVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTPKTQLENSDNFEEQKETLYENSESRNDPSLDKEIVTAEHYLKQLKINLKELESQREELMKEITEMKSMKEALRRHIESYNSEKNKLYLDSNELSNNPPMINEISLGESPPVKHVATASSVARSSVKPKFWKFFSSAKPQTEQSIQGVSTNNTNSIVKSAPVLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDANMGQSKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEIEKQFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLYNLALVFAPGLIRDFSGEKDIIDMKERNYIVAFIFGNYKDILT", "function": "GTPase-activating protein (GAP) for CDC42 and/or RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase; acts at a step between the G-protein and the MAP kinase module. Dominant suppressor of bud emergence defect caused by deletion of IPL2/BEM2. Involved in the control of polarized cell growth and proper bud site selection.", "AFDB_id": "AF-P39083-F1-model_v4" }, { "swissprot_id": "Q8K1T5", "sequence": "MLFMAGPAASWSLRPLGLHGVPQALCAVLLTVLVMKTLVLGDTKLEDLHPQSLPLNKYLNCYRCLLETEELGCLLGSDTCLTPLGSSCVTLHIKNSSGFNVMVSDCYSKEQMVHCSYTRASPVFGFWIFYQCCFLDFCNNPDNRKNSMH", "function": "May have a role in hematopoietic cell differentiation.", "AFDB_id": "AF-Q8K1T5-F1-model_v4" }, { "swissprot_id": "Q4MY95", "sequence": "MNCTVGNNIYHTYINYFVNNIYNSLSRNINSKINKYYNYYKKSKIFKNIKFYFNLLTFESNYCCDSGQNKYLYDGYNSYYFINIPLQIKFNNLKSRFINYNIINIPKINQSGDIILNGYLRLPILYLQLATNNISYIFNEKITRTYFIKIKNNIYLYIYLYDDFITVYINSYKIKNDLFSMYNNVSFKNKYINFSKIDNVIYVMNLKNNNIKYHIFDKTININNFVNNTMFMDILSIVNKFLNLNLKKKFIQSSNNLINKSTNSVLKTIFRQFTKSVTIFDIEKYCDKLLYKKKIFRSFNIVLFKEHLLVNPVIHYTDQLNVLSYLTNKFKINIFGYSNSSNDKFKVSTNLRKIQSDYIGFINIVNTPDGDTCGLISKLANNTILDKFKLKLINCNNEYFENFTKIDITSKNLYNMTSNNFINIKKNSTFKVKQIEVFKNNEFKLINFDKNKTNKNLNVFNTLSITELIIPFLFNNDPCRGLMGSKMHTQALPLIYNEHPYVMTKYNHMNGLLFNKCITSLCEGIIVSVNNYKIIVMDDKNRYLHYYLYPFNVLDYNSFVSYKPIVWVGEKINIGKILALPSDLKHSEFTLGVNNLLNYSFYNGYEHEDAIVINKNLIIEDILTSISFDVYEEYLSINKLDYVELTLRHLLEYNRYNRYLINEVGVSSNQDYMLFGDILSTKIRYELSLSKNKKFFKVFKLIFKENKKLIVYTKPLTIKRGGEGRLIKYEILGYSKFRQLDAMYPEINVSYLTLRFFIFKIDRINIGDKLCGRHGNKGVVSKIVDNIDLPYTFRGLCPYSITSPIGALARINLGQFLEGSCGYFGLNFNCRIKAPINLYNYHLYSNMYLKNIFNSLNVYNNSYINFSIEKYLRDFKTGYQLKNFNLMLMPYFLKLMHTSKSKFQYRTVGKYSSLTQQPVKGKRVNGSQKFGEMEVWALESHGSAYTIRELGYIKTNVKYFKKFEHKGYKGSETFKVLTLELKNVLININRVDNYSYFNQKIKYNY", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "AFDB_id": "AF-Q4MY95-F1-model_v4" }, { "swissprot_id": "P72943", "sequence": "MISARQLAFLILRDINRRDSYTDVAIDRALQKHPLSPPDRRFCTELVYGVVRRQRTLDCLIEQLGDRPIGKQPPDLRRIVQLGLYQLRYLDQVPASAAVNTGVDLAKANGLKGLSKVVNGMLRRYQRAEEQGKNILDQEKISLGEQYSFPDWLMELFEQTWGKAETESLCAYFNQNPSLDLRINPLKTSRVEVAQSLAELNLTTTAMAGLPQGLRLGGKTGAITQLPGFAEGWWTVQDASAQWVAQILNPQPEETIFDVCAAPGGKTTHIAELMGDQGQIYAGDRHGWRLQKLAVTQQRLGLTSIKIWEGDLTQPGVKPPVELVDRALLDVPCSGLGTLHRNPDLRWRQTPATIATLLPLQQALLKAIAPLVKSGGTLVYSTCTLNPAENEAQIERFLQDHEDWRSEPFEWTSPQGQTNSVTSGMLTILPHHHHQDGFFIANLKKA", "function": "Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.", "AFDB_id": "AF-P72943-F1-model_v4" }, { "swissprot_id": "A0A161IUT7", "sequence": "MAISDMPESTGTTATTATMPHGGSDLRRRHNATETTEVSDSNSKTTDPDSGNSVRESVRVRDSSTDESLARKSCEDDGSRSEVVIESANPVTNGNDGGEKIANGEDRRTDFAAVKLAYRPSVPAHRRIKESPLSSDAIFRQSHAGLFNLCIVVLVAVNSRLIIENLMKYGWLIKTGFWFSSRSLRDWPLLMCCLTLPIFPAAAFVVEKLVQWKYISEPVVLLLHFIITTAALLYPVFVILRCDSVVLSGVTLMLFACIVWLKLVSYTHTNYDMRALAKSIDKGDVLPNSLNTDYPYSVSFKSLAYFMVAPTLCYQTSYPRTACIRKSWVVRQLVKLIIFTGVMGFIIEQYINPIVKNSQHPLKGNLLYAIERVLKLSVPNLYVWLCMFYCFFHLWLNILAELLRFGDREFYKDWWNAKTVEEYWRLWNMPVHKWMVRHIYFPCLRNGIPKGVAILIAFFVSAIFHELCIAVPCHIFKLWAFIGIMCQVPLVLITNYLQNKFRNSMVGNMIFWFFFCILGQPMCVLLYYHDLMNRKGKTE", "function": "Major contributor to triacylglycerol (TAG) synthesis and oil accumulation in developing seeds. Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA. Has a marked preference for oleoyl-CoA as substrate.", "AFDB_id": "AF-A0A161IUT7-F1-model_v4" }, { "swissprot_id": "Q0KHQ5", "sequence": "MPSARPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETESAVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQEEMHEQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDNLKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLSLIEVSREAYADEEGSLSGSMISLAHSNSSTSFPAGSL", "function": "Induces in vitro expression of actin-dependent filopodia-like cytoplasmic protrusions which firmly attach to the substrate. Antagonizes the activity of isoform D.", "AFDB_id": "AF-Q0KHQ5-F1-model_v4" }, { "swissprot_id": "Q6MGL7", "sequence": "MKDNQEQAAPIVYWRIDEWFPDLSPDLRTRLKTYHEELLKFNRTLNLISAKTVFVADALHFADSIMASQAIMKSNPSLDKIYDLGSGNGFPGMIFALLYPKVQVVLVEFDQKKCEFLNHVAGVLKLSNVTVENRTIESFPDGSMKYVMARGLANISKSIMMTRKVVPKGGVFYHLKSEEWGIEVGDIPTQLCSVWAPSLVGEYKLPIGAIKFSVVKTDKIA", "function": "Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.", "AFDB_id": "AF-Q6MGL7-F1-model_v4" }, { "swissprot_id": "Q9ULJ3", "sequence": "MEGLLHYINPAHAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTNKENESQTVFQLDFCEPDAFDNVLNYIYSSSLFVEKSSLAAVQELGYSLGISFLTNIVSKTPQAPFPTCPNRKKVFVEDDENSSQKRSVIVCQSRNEAQGKTVSQNQPDVSHTSRPSPSIAVKANTNKPHVPKPIEPLHNLSLTEKSWPKDSSVVYAKSLEHSGSLDDPNRISLVKRNAVLPSKPLQDREAMDDKPGVSGQLPKGKALELALKRPRPPVLSVCSSSETPYLLKETNKGNGQGEDRNLLYYSKLGLVIPSSGSGSGNQSIDRSGPLVKSLLRRSLSMDSQVPVYSPSIDLKSSQGSSSVSSDAPGNVLCALSQKSSLKDCSEKTALDDRPQVLQPHRLRSFSASQSTDREGASPVTEVRIKTEPSSPLSDPSDIIRVTVGDAATTAAASSSSVTRDLSLKTEDDQKDMSRLPAKRRFQADRRLPFKKLKVNEHGSPVSEDNFEEGSSPTLLDADFPDSDLNKDEFGELEGTRPNKKFKCKHCLKIFRSTAGLHRHVNMYHNPEKPYACDICHKRFHTNFKVWTHCQTQHGIVKNPSPASSSHAVLDEKFQRKLIDIVREREIKKALIIKLRRGKPGFQGQSSSQAQQVIKRNLRSRAKGAYICTYCGKAYRFLSQFKQHIKMHPGEKPLGVNKVAKPKEHAPLASPVENKEVYQCRLCNAKLSSLLEQGSHERLCRNAAVCPYCSLRFFSPELKQEHESKCEYKKLTCLECMRTFKSSFSIWRHQVEVHNQNNMAPTENFSLPVLDHNGDVTGSSRPQSQPEPNKVNHIVTTKDDNVFSDSSEQVNFDSEDSSCLPEDLSLSKQLKIQVKEEPVEEAEEEAPEASTAPKEAGPSKEASLWPCEKCGKMFTVHKQLERHQELLCSVKPFICHVCNKAFRTNFRLWSHFQSHMSQASEESAHKESEVCPVPTNSPSPPPLPPPPPLPKIQPLEPDSPTGLSENPTPATEKLFVPQESDTLFYHAPPLSAITFKRQFMCKLCHRTFKTAFSLWSHEQTHN", "function": "Acts as a transcription repressor.", "AFDB_id": "AF-Q9ULJ3-F1-model_v4" }, { "swissprot_id": "Q81MS2", "sequence": "MYRLSQYETPLFTALVEHSKRNPIQFHIPGHKKGQGMDPEFREFIGHNALAIDLINIAPLDDLHHPKGMIKEAQDLAAAAFGADHTFFSIQGTSGAIMTMVMSVCGPGDKILVPRNVHKSVMSAIIFSGAKPIFMHPEIDPKLGISHGITIQSVKKALEEHSDAKGLLVINPTYFGFAADLEQIVQLAHSYDIPVLVDEAHGVHIHFHDELPMSAMQAGADMAATSVHKLGGSLTQSSILNVKEGLVNVKHVQSIISMLTTTSTSYILLASLDVARKRLATEGKALIEQTIQLAEQVRNAINDIEHLYCPGKEMLGTDATFNYDPTKIIVSVKDLGITGHQAEVWLREQYNIEVELSDLYNILCLVTFGDTESETNTLIAALQDLSAIFKNKADKGVRIQVEIPEIPVLALSPRDAFYSETEVIPFENAAGRIIADFVMVYPPGIPIFTPGEIITQDNLEYIRKNLEAGLPVQGPEDMTLQTLRVIKEYKPIS", "function": "Catalyzes the formation of agmatine from arginine.", "AFDB_id": "AF-Q81MS2-F1-model_v4" }, { "swissprot_id": "B3E0Z6", "sequence": "MHQLGIEWNKLIAQIINFVIVLWVLNRFAFKPVLKILEERRKKIAESLQNAEKIKQELAEAEEARKEILRKANEQASFIVAEAQKVASYQGEKKIQEAVEEAKRVLKKAEESAKLEREKAKEEMRREILNLVIEITSKVVGKTLTLDDQERLKNEVLSKLPQKEGHEAYSRN", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-B3E0Z6-F1-model_v4" }, { "swissprot_id": "O53859", "sequence": "MVWMRSAIVAVALGVTVAAVAAACWLPQLHRHVAHPNHPLTTSVGSEFVINTDHGHLVDNSMPPCPERLATAVLPRSATPVLLPDVVAAAPGMTAALTDPVAPAARGPPAAQGSVRTGQDLLTRFCLARR", "function": "May play an essential role in M.tuberculosis replication and survival inside the host cell.", "AFDB_id": "AF-O53859-F1-model_v4" }, { "swissprot_id": "Q5ZIA0", "sequence": "MALNKSMHARNRYKDKPPDFAYLAGKYPEFRQHVQTTLAGRVSLNFKDPEAVRALTCTLLKEDFGLTIDIPLERLIPTVPLRLNYIHWVEDLIGHQDADKRVLRRGIDIGTGASCIYPLLGSTLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKVPQKTLLMDALKEESEIIYDFCMCNPPFFANQLEAKGVNSRNPRRPPPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELKIQGVPKVTHTEFCQGRTMRWALAWSFYDDVQVPSPPSKRRKLEKPRKPITFTVLASTVKELSIKAAAMGWDAVEGIAVVRAWIEKILADLKVQHKRVPCGKDEVSLFVTAIENSWVHLRRKKRERVRQLRELPRASDDVLQAMEEEKNSQNSVSNSVDCEKSKTEDSETELVAPDEDVHLTADDELREESATKELSEHMEEEETEAKQTEASFNEGSSSAEQGAQPSEEAGNLTAEKGQSPKETSRCFLFKCLMNVKKEGNDVLVEMHWVEGQNRDLMNQLCTYLRNQVLRLVAS", "function": "RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A splicing and protein expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs.", "AFDB_id": "AF-Q5ZIA0-F1-model_v4" }, { "swissprot_id": "Q9BRG2", "sequence": "MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLRRSFSEDTLMDGPARIEPLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLLEGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR", "function": "May play a role in JNK activation.", "AFDB_id": "AF-Q9BRG2-F1-model_v4" }, { "swissprot_id": "Q9VMU5", "sequence": "MMTSLQLETSLPAVEEQVQREKDNDSAEDSHTASTTPTRIPHPAVARFRRSASLRLRGNPAELGLRAEHCPAGGGGFSSRAKLTAIPSSLETRSHPVHLRRNRSWCNLGHKTEQEPEVEASTEALCNAAQCLSLDKEALAPKVGNSSMANGKPRNLSLQLNGGSDISSSGTSSSSSNNKESSPRTTRTPRTPQTPQTPQTPASGVAASVAETPHSCIRQGNCVKANQVKLSTLHESKISPRTPPVTPDSPSTYLDDDIDSMYSFATTTSGRSTMSCEHPYVARNGTTFSGRKMKYVVHCSNYAGQVGPDYLTPTQRAQRQIRRLKELLCIARQDLEQKDTELLRLTREVVELRLFKASLSSPEERSASSDAVTVREAELKTSQDVSPIVDMVDEGNAKGSPRHLSRQQQQQANHSLQAMQMSAEMQSSYADSGHFEDLTMSSVHSKDSQTQSEACGTATPDGEADVGCGAGGDSASNLENYELQRQELISMYEHRIEELIRSQDSATSDLKRSHNDKVEALLQKLAECNTRYSDMVPDYEQAKQRIRELEKQLEDLQRKLIEHEEKQNKMYLHMYQQGQEAERISRADQALDLAQRQPESKVSINELLHQLQSTQDELENIRASECRMRECGSNHALLTAKEAISLWVLGARKTIYRRLLEAQKNRTHVDPEVTLQFLKSAIFYFLTDKENSQGHLQAIESILEFTDAEKQKISAANRTPK", "function": "In adult males, modulates sexual behavior by playing a role in sex discrimination and maintaining normal levels of sexual activity towards both males and females.", "AFDB_id": "AF-Q9VMU5-F1-model_v4" }, { "swissprot_id": "Q75CZ0", "sequence": "MKSSAQLCMEARNYNFNAAAPLRLYLATCVRLVEEAQAAAQADDVARAYMLYVRYLDLCMHQLSGHREVQQPVTDAERLSRDEYEQLLRLEVPAVLRLTEELKSAVDLRHERGRASLARSVVPEAGRGEHSRQEVQLPPSFDEERFNRTVQWFLAAGRSMSLPVSAEEPAVREVFSYPELPKLSMAAESWAPS", "function": "Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.", "AFDB_id": "AF-Q75CZ0-F1-model_v4" }, { "swissprot_id": "P42661", "sequence": "MMMRCVNGQTAQDHLVTQLPGLSGNIGVKSYTGYLLANATRGRYLFYWFFESMRNPSQDPLVMWTNGGPGCSSLGGEASEHGLFLVNADGATITRNPYSWNRVSNILYIEQPVGVGFSYSNSTDDYQNLNDVQAASDMNNALRDFLTRFPQFIGRETYLAGESYGGVYVPTTAYNIVEGNGKGQQPYVNLVGILVGNGVTDAEADSNSIPPMMKYHSLISIKYYEEGYKACQGDFYANQNLPACQKFLTDSSNAMGNINPYYIYDSCPWLGINLQQKLKTTQEMTFQVLDPKTQQPVKIHPLFQMYKHGGWSKRVANERNFAPRFETDAPCVPNQSIAKYFRRLDVQQALGVRRKTADPNGWNICTGIINYTQVYSTILPFYAKLLPHIRILVYSGDTDMVVNGLGTQAAIDKLQLQETSSWRTWEFDSALGTVVGGYIRKFEKSGKGLTFITVRGAGHMVPLVKPDSAFYMFKNFIDGTCC", "function": "May be required but is not sufficient for increased virulence.", "AFDB_id": "AF-P42661-F1-model_v4" }, { "swissprot_id": "A0QQ71", "sequence": "MKIRAHHKIATAAACVALLASACSGSDKPQSTTAEGFPETITLAAIPAENSSDLKASYDPLIKMLEKQTGSKVEFVQASDYAGVVEGMIAGNVDLAFFGPFAYVVAGVNGAKMTPLGAVIKDEGGAPGYQSYGLARADEDNINGLKDFAGKKVCFVDPGSTSGFLYPTAGLIEEGVVKSGSEADISAAMSPIFAGGHDSSALAIANGDCDAGFAFDTMVDKTMIDKGDLKPGQLKTVWKSDMIAGSVFAANDALGPEVIDKLKTMFAQDANVKSFEEEGFCEGDACRITDERAWGVVPVTDADYDGVRHVCDVTGSEKCKG", "function": "Part of the ABC transporter complex PhnCDE involved in phosphate import. Responsible for phosphate binding.", "AFDB_id": "AF-A0QQ71-F1-model_v4" }, { "swissprot_id": "P43535", "sequence": "MASIGSQVRKAASSIDPIVTDYAVGYFNHLSGITFDAVQSKQVDLSTEVQFVSDLLIDAGASKAKVKELSESILKQLTTQLKENEAKLELTGDTSKRLLDINVLKSHNSKSDINVSLSMLGVNGDIEHTGRKMETRVDLKKLAKAEQKIAKKVAKRNNKFVKYEASKLINDQKEEDYDSFFLQINPLEFGSSAGKSKDIHIDTFDLYVGDGQRILSNAQLTLSFGHRYGLVGQNGIGKSTLLRALSRRELNVPKHVSILHVEQELRGDDTKALQSVLDADVWRKQLLSEEAKINERLKEMDVLRQEFEEDSLEVKKLDNEREDLDNHLIQISDKLVDMESDKAEARAASILYGLGFSTEAQQQPTNSFSGGWRMRLSLARALFCQPDLLLLDEPSNMLDVPSIAYLAEYLKTYPNTVLTVSHDRAFLNEVATDIIYQHNERLDYYRGQDFDTFYTTKEERRKNAQREYDNQMVYRKHLQEFIDKYRYNAAKSQEAQSRIKKLEKLPVLEPPEQDKTIDFKFPECDKLSPPIIQLQDVSFGYDENNLLLKDVNLDVQMDSRIALVGANGCGKTTLLKIMMEQLRPLKGFVSRNPRLRIGYFTQHHVDSMDLTTSAVDWMSKSFPGKTDEEYRRHLGSFGITGTLGLQKMQLLSGGQKSRVAFAALCLNNPHILVLDEPSNHLDTTGLDALVEALKNFNGGVLMVSHDISVIDSVCKEIWVSEQGTVKRFEGTIYDYRDYILQSADAAGVVKKH", "function": "Acts as a positive activator of the GCN2 protein kinase activity in response to in response to low amino acid, carbon, or purine availability. Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes; during this process, GCN20 helps GCN1 to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity. Participates in gene-specific mRNA translation activation, such as the transcriptional activator GCN4, by promoting the GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) on 'Ser-52', and hence allowing GCN4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.", "AFDB_id": "AF-P43535-F1-model_v4" }, { "swissprot_id": "Q54VX5", "sequence": "MSSSDDTSSDYDDYDDYELDEDDTEKEPSKWNNVRDGWQEFLEDETAFFVSQEDQSKQSGDIQIDDSNKFYDPLGILKLPPRKAASVKKELLSLESESFSPVTFLSEIHSQTNFTELSIGVKKLKEESTSKAKEIKYLVKENFEHFVKCKDTVDEVYNLISNSKMLEDMSGSFIKIINKSSTVYDPLLSNKKKADEIRKVLTLLNKYKVIFKLPGKIQENIKQNEYEKAVHNYKNAKTLITSSQKKEFQKILLDIEKIAEDFRIQLFHALADPSTKLEQLKKSIKTLMEIGNGKGDFSQIGDPCWYFLSTRYNAITLLIKQCSEDNTLPNYKIIRKLSILLLSNVPNLFKMGVYYIEGKFEDNKEYLRYKQQQQIQLQQQQQLIQQQQQLQQQQQQQQSGKTKDSKSVNVVVYYLDETFSSYRMDQEKKVKDLIELCRKRFIEEEDDEFCLYKLSEKKIKSEDKSTTTTNIKLLELSHDESPFKLQKKWADKNSSTKNHRFLFKRKNEEFTVNNSKAGNGTSIYDKEANITQIDLNASYKTHKKQNSAATSAMNEEKFKQLIINIMELYSSKVEQLFFDQNQEDFPEDSDDEEENLFDQIISTTSVNEDGNHHHGGGGGGGGGGGDTINSSDLSIHMVENVNEVIKCQEMLQGIGMPELYLSSINSLTESLILHFIRQICSEMVAEVSFLYLLEDWTINESSEDALASGNQVDGMITTRLMGEFVNTIKVNLAKLSFLSNKPMLLPSVESALCEAIESFGDCLHHLAFNNESIQSTIEDSLNQMSNDEKAENELNGIIPKIDISSPQQQQQQTQNQSQQGQVQQGENQQQQTSSYMTTEFNSSEKLLLTLSNCSTVVSKTAVQLRGFYVGLFHQPMGSYLKKVIEKLGVLERLILERYVNEKNLMIGEFITRGVLFSGSTWLVNSQPTKVSSFILTILTKMVFIHHEIMKTINSIDISFGVIQRIFEFLLISLRHNFSLVDPLFISNEGKSQFLLDILFIENVLESYGNEKTVKLSSFIRKDLLFLNPIQQQQQQQPTQSISHQHQQQSSTSRFYSTLNYGGGSGFNINATTANLDPILKRNIEKTSLLFSCFKI", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.", "AFDB_id": "AF-Q54VX5-F1-model_v4" }, { "swissprot_id": "Q72U69", "sequence": "MNSNPKKKFLKLIKIKSDIILLIPIFLFLVCCKSGDFSLLSSPINREKNGTEIVKFSIHPYKGTVIRLGEEILPFKVLEMDKNIALVEMAIPVYKDEKEIELKLSSPGFQNSSYRIRKPEELNEKLIALDKEGITHRFISRFKTGFQPKSVRFIDNTRLAIPLLEDEGMDVLDINSGQTVRLSPPEKYKKKLGFVETISIPEHNELWVSQMQANAVHVFDLKTLAYKATVDLTGKWSKILLYDPIRDLVYCSNWISEDISVIDRKTKLEIRKTDKIGLPRGLLLSKDGKELYIAQFSASNQESGGGRLGIYSMDKEKLIDTIGPPGNKRHIVSGNTENKIYVSDMCCSKIEVYDLKEKKVQKSIPVFDKPNTIALSPDGKYLYVSCRGPNHPTEGYLKKGLVLGKVYVIDTTTDTVKEFWEAGNQPTGLDVSPDNRYLVISDFLDHQIRVYRRDGF", "function": "May be involved in virulence. Binds human plasminogen (PLG) and stimulates its proteolytic cleavage to enzymatically active plasmin in the presence of an urokinase-type PLG activator in vitro. Activated plasmin has proteolytic activity which may help the bacteria to spread throughout the host by degrading extracellular matrix components, facilitating tissue penetration and invasion.", "AFDB_id": "AF-Q72U69-F1-model_v4" }, { "swissprot_id": "Q8Z8I0", "sequence": "MHKQLPVICVAAGIVLLAACTNDGGQQQTTVAPQPAVCNGPTVEISGAEPRYEPLNPTANQDYQRDGKSYKIVQDPSRFSQAGLAAIYDAEPGSNLTASGEMFDPMQLTAAHPTLPIPSYARITNLANGRMIVVRINDRGLYGTDRVISLSRAAADRLNTSNNTKVRIDPIIVAPDGSLSGPGMACTTVAKQTYALPPRPDLSGGMGSASSAPAQPQGDVLPVSNSTLKSDDTTGAPVSSSGFLGAPTTLAPGVLEGNEPTPAPQTAPVSAPVTAPATATPVSAPAAAAPVSAPVSAPAAAASGRFVVQVGAVSDQTRAQQYQQRLSQQFSVPGRVIQNGAVWRIQLGPFASKAEASALQQRLQTEAQLQSFIASAQ", "function": "Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.", "AFDB_id": "AF-Q8Z8I0-F1-model_v4" }, { "swissprot_id": "Q30SS4", "sequence": "MSLEKDIESFVKSLDLELYEISVARDGDDSIYRVNVLSTQIEDGKKKGVSLDECVHLSRLISPLLDVTPPMSGEYRLEVGTPGIERKVSTLKQFVLSIGERVALTLKSKEKLKGLLLRVEESNIYLDVDAEEVCVEFAQISKAKTYFEW", "function": "Required for maturation of 30S ribosomal subunits.", "AFDB_id": "AF-Q30SS4-F1-model_v4" }, { "swissprot_id": "Q9CAC5", "sequence": "MSRCGSLGLYAPNALPSLSLKPRSVKSPFCITSHTKPNDTLLHNVNKMRAKACDILGAKKTILAAQLGAVLATIDHPALAITGVNNQQELSSVVLDIGIISVWYFLVMPPIIMNWLRVRWYRRKFFEMYLQFMFVFMFFPGLLLWAPFLNFRKFPRDPNMKNPWDKPTDPDSIKNVYLKYPYATPEDYDLD", "function": "NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-Q9CAC5-F1-model_v4" }, { "swissprot_id": "Q9PG89", "sequence": "MQPDFLILGCLLCIVLVLQILALLRRSDHTALDHVLREEHRVGRAELREQLETLERQQEVRLASFARSLTDLVARIDQRLDQLTASLGEDARKGRQEASEGQQRFADALGQRLTELTQRNAQSINEMRTTLEQQLHVLRADNAQQLEQIRAIVDEKLQTTLNTRLDSSFKLVSERLEQVQRGLGEMQQLATGVGDLKRVLTHVKSRGTWGEVQLDNILDQTLTQEQYARGVRVCPDASEIVDFAVRLPGRGQYEAPVWLPIDVKCPKEDYERLLDAQEQADQELVRTMGVQLERAIKIQAKSIRDKYIVPPHTTDFAVMFLPTEGLYAETIRRPGLADVLQREYRVVVAGPTTVTALLNSLQMGFRTLAIEQRSSEVWSLLGAVKSEFGKFAGILEKAEKQINTVGKSLGEAGRKTRTIERRLRGVESLSQEQTQVLLDGLDVDAAESDVDSDASF", "function": "Involved in DNA recombination.", "AFDB_id": "AF-Q9PG89-F1-model_v4" }, { "swissprot_id": "P83211", "sequence": "ALRKVDRNRFVLDNVTPQPREAKRYKEEEEFPGHGRRRRRRSKGKGKAKGKGKGKGKRRRRRKGKGKGKGKKKGKGRRRRCRRGRGCKKRKGKKGKGRRRRRGKKGK", "function": "Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.", "AFDB_id": "AF-P83211-F1-model_v4" }, { "swissprot_id": "P30290", "sequence": "MDSSTTIPITPTRTPCFFNISSSFNEHSPLNFYDEPIYNFSSGHEENQSHKSSKLTFFKPSNTKRSPHTPMQNNAKAIRLSTTVRHGIFKNSDLDGCSKPFAFSSGLKLSKKIVDASTPIDLKRKRAVTSLSTGLLSKREKWSLWEGNLTNPRSEQPHTPCKKGTKIKLKPPQSPLSPTTSLLARKCKHIDLDTFSRLDHPNSDSSDETFEMEELPSLSYGSEDLLEFCETPCKSQPIFLSSSHVNNWDEKDVPSSLSWTPTSPIFLNINSADDYEEEEDWTSDLRIRFQQVKPIHESDFSFVYHVSSINPPTETVYVVKMLKKNAAKFTGKERHLQEVSILQRLQACPFVVNLVNVWSYNDNIFLQLDYCENGDLSLFLSELGLLQVMDPFRVWKMLFQLTQALNFIHLLEFVHLDVKPSNVLITRDGNLKLGDFGLATSLPVSSMVDLEGDRVYIAPEILASHNYGKPADVYSLGLSMIEAATNVVLPENGVEWQRLRSGDYSNLPNLKDLLLSKEKVQINKVRCAESLQCLLQRMTHPYVDCRPTTQDLLAMPEMIFISEHSQKAAIIYEDHNSWLET", "function": "Protein kinase that acts both on serines and on tyrosines. It acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2.", "AFDB_id": "AF-P30290-F1-model_v4" }, { "swissprot_id": "P31811", "sequence": "MAASFSVTRRFFDDKNYPRGFSRHGDYTIKESQVLEQYGQAFKALDLGEREPATKEEKDFVAFCRGERAAETFFEKTWNKYRTRINTKKRVYTLSSDVSEAASGGEDYSGE", "function": "Not known, a mutation in ORF3 causes a slight decrease in transformation efficiency.", "AFDB_id": "AF-P31811-F1-model_v4" }, { "swissprot_id": "A0A411KZU9", "sequence": "MAIASSIGLVAEAIHRHKTPERPIESENDIARYPAEDEQWALDELQDELCQEEPSDSEDQPKKKIRNPAKLADDFLKRYPPPPSGSAPAGRLPLPVIIPQRRPGVRVRGFVRAYAPDLQACGIDQDTFMDFLVTMTRAGRAPQWMGAANLTAAAAFALPGHAIGCGVGFAIQVVNAIAMEMRGRVQANGFLQKLNQGFFQPRGLYCLVLSFDNTHEEAMTDESLATAIATTTDPKTGVRKYTDKLRSHSGTTGPSEFPESAPLVFPVLDWLETNANAEQAEKLGRYKKFRKFVADYYDRRAQAEYAARNPTSPLAAPPRRGFTSKLADPNDDTNKSPISLATGGLVPYNTTWRETRNSEGRRPPRKIADKVLYMIIVNMPSDDDMSRAESIMATEATTEPSVQSDDAEAAKG", "function": "Part of the gene cluster that mediates the biosynthesis of burnettramic acids, an unusual class of bolaamphiphilic pyrrolizidinediones that display potent antibacterial, antifungal, and cytotoxic activities. The first step of the biosynthesis of burnettramic acids is the hydroxylation of proline by the proline hydroxylase buaE to generate 4-hydroxyproline. The PKS-NRPS buaA and trans-enoyl reductase buaC construct the highly reduced polyketide chain, and the condensation (C) domain of buaA then catalyzes the amide bond formation with the activated 4-hydroxyproline. This is followed by the R domain releasing the nascent polyketide-peptide directly via a Dieckmann condensation to afford a tetramic acid fused to the hydroxyproline, generating the bicyclic pyrrolidinedione moiety. The cytochrome P450 monooxygenases buaD and buaG are likely responsible for the multiple hydroxylations on the polyketide chain and its terminus, although in the heterologous context, buaD does not appear to be required. Therefore, while buaG may be a multifunctional cytochrome P450 monooxygenase, it cannot be ruled out that the two secondary alcohols on the polyketide chain could have an acetate origin. Finally, the glycosyltransferase buaB transfers beta-D-mannose to the aglycone burnettramic acid A to form burnettramic acid A. Burnettramic acid B is a minor cis-pyrrolizidine epimer of burnettramic acid A and it is likely that small amounts of it form naturally in acidic environments. The role of the uncharacterized protein buaF in the biosynthesis of burnettramic acids has still to be determined (Probable).", "AFDB_id": "AF-A0A411KZU9-F1-model_v4" }, { "swissprot_id": "Q6C6D9", "sequence": "MREIITLSFGQTAGHINADYFNSQEHYFPLATKSTSDPTVRFRRGVATDSRTETYNPRLLTWELKGGYGAFQAFNQFYTEGDKSQPQVWNEGEIKEIKEQPVDKNEYQKALDLGRENASQLNTDTTKRWTDYNRLFHHPKTRHQLDNWLFDPDTAPQGIHRGGDQKWTGFDVGVNEWEHVLNSDKEYLDSTLRSWVEECDSLGGLNVVVDDSAWAGVAAKILANYRDDFDAKGTVVTWSVEAKPEKKTRETQKNAIQTTVALSQVSSIYIPVSFPTKTPIDADFDPTSPWHQAALFGLSVYEPVQLMATQRTGGLSLDAMAALLDTTGERNIVSEVGGTLTDVDGDKSTVQYDSRLFQELFLPSRIPPKTPHVFSDLSIARLEDQDDDANSYRLNQPMPEVSSQPEFTKQFVSSKTRLAVTTKPRRTLLDMAKFVSVYERGDEREEMKQELGDMASKYEHGWEEESDDDDDY", "function": "Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.", "AFDB_id": "AF-Q6C6D9-F1-model_v4" }, { "swissprot_id": "Q9NBL2", "sequence": "MTAHENEVQLFNRGEKVLCYEPDESKARVLYDSKVLAVYERKDAANLRYFDYKIHFQGWNSSWDRNVRAASLLKDNEENRKLQRELAEAAQLQKTGGYSYKDSKTPTLPSSKKKRLARGGHVEDPTADPLDISLPSSKKKRLARGGHVEDPTADPLDISLAHLPATPKPELPAQQKRGARSRDGSGNRSRDGSGNRSRDNSSGRKKQRDKSKGGDKNDDGERRSARSQFSLHVSPKDTHTTDAEKRIHQEDRVMLRISERLREYMEYDYNMVCKLEKQHALPARTPIVTILENFVKQRAVELAIGIKQDSSRARNTLSRNARMEREYDRVMSIVCMLKEVVDGLRIYFEFHLEDHLLYREEKDYALGFLTDNNMKNCSLLLNKSYEFINPSGDNELISMAGNVNGTNGVDGPLLGDIEYENQLQKCLRYIEKNSAKNNIALAYTAAYKLPMEMRGFLRETFSWSLLSEESPPEKSIIFGAPHLARMLVLLPECLNASPISNEKLVDLLPHLDSFINYLENHKEWFDKQNYLDPLIDQGRELSV", "function": "The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation).", "AFDB_id": "AF-Q9NBL2-F1-model_v4" }, { "swissprot_id": "Q3BQ14", "sequence": "MTDPFTSDGAKMPPKPFTVEEGRRQVRSFVLRQGRFTPAQQRAFDDLWPRFGLDYTGAPRDLAATFGRDAHKVLEIGFGNGAALRFAAQQDPSRDYIGIEVHAPGVGRLLNALDEDGSTHVRLYHHDAVEVLEHEIADGALDEVRIYFPDPWHKKRHNKRRLIQPAFAQLLVRKLREGGRLHAATDWADYAEQMWDVLDATPGLVNRAGPRGHVERPAWRPQTHFETRGQKLGHGVWDLLYDRDSGIGNRKGNCPRRPDNPQRPQFSLCQFPIPDSPFPAPNGHRADADQRYEARPRAGRFHDGDVPVRAHSRRRGGIDRAGGLGRHRTGGAGRIVRRFLR", "function": "Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.", "AFDB_id": "AF-Q3BQ14-F1-model_v4" }, { "swissprot_id": "P33959", "sequence": "MSESHLYTYGIIDDNESLALNVDGVAGATRAYTVSYRSLSAVVSDIETTDPERTDAAVEAHNTVLQAVLEHDATRAVVPMSFGMAFKNARTLKGVLRGARRALRSTLTEIAGTVELGVKVLAPGDDTAVDTAAVRSDVTARLSALSVGETENDCFTDRLIINKSYLVEHDTRDAFDAAIDEIDAAHDDLTVRYTGPWPPYNFVDIHIGAEQAQQGGR", "function": "May play a structural or regulatory role in gas vesicle synthesis.", "AFDB_id": "AF-P33959-F1-model_v4" }, { "swissprot_id": "P23643", "sequence": "MVKKKTNNDKGKEVKENEGKLDIDSESSPHERENDKKKTEDDSLRATESEETNTHNANPNETVRADKFSQEESRPIEDSPHTDKNTAQESCQPSSAEDNVINTDITSLNEKTSTNDEQEKGLPLKISEGPFTISTLLDNVPSDLIYTCCEAYENHIFLGTTTGDLLHYFELERGNYMLVSQTKFDAESNSKIDKILLLPKVEGALILCDNELVLFILPEFAPRPNTTRLKGISDVVICNFSRSSKAYRIYAFHAEGVRLLKISADSLVLTKAFNFKLIDKACAHEETLMVSKLNSYELINLKSSQVIPLFRISETDEDLEPIITSFNEQSEFLVCSGGGSYDSGAMALVVNHHGDIIKGTIVLKNYPRNVIVEFPYIIAESAFQSVDIYSALPSEKSQLLQSITTSGSDLKISKSDNVFTNTNNSEEFKEKIFNKLRLEPLTHSDNKFRIERERAFVEESYEEKTSLIVYNNLGIHLLVPTPMVLRFTSCEESEIDNIEDQLKKLAKKDLTKFEHIEAKYLMSLLLFLMTLHYDHIEDEVMKKWCDFSDKVDIRILFYMFGWKVYSEIWCFHGLINIVERLKSLKLTNKCENILKMLLMMKNELKKKNKTGLLTNDFDDIMKTIDITLFKLRLEKKETITVDMFERESYDEIIREINLHDDKLPRIELLIEIYKEKGEYLKALNLLREAGDYISLVSFIEENLKKLPEDYIKERIADDLLLTLKQGDENTEECAIKKVLKILDMACINKNDFLNKIPAEETSLKVSFIEQLGVQNSNDSKFLFNYYLAKLREIINQSNIWSILGDFIKEYKDDFAYDKTDITNFIHIKLKHSLQCENFSKYYEKCENLKSENEKDDEFINFTFDEISKIDKEHILTLLFFPNELTNWVSSEELLKIYLSFNDFRSVEKYIGKQNLVAVMKQYLDISSLNYSVELVTNLLQRNFELLDDTDIQLKILETIPSVFPVQTISELLLKVLIKYQEKKEESNLRKCLLKNQISISDELSRNFDSQG", "function": "Required for sorting and processing of soluble vacuolar proteins, integrity of vacuolar morphology, efficient segregation of vacuolar material into the bud during the cell cycle, acidification of the vacuolar lumen, and assembly of the vacuolar H(+)-ATPase.", "AFDB_id": "AF-P23643-F1-model_v4" }, { "swissprot_id": "Q6GPH4", "sequence": "MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQQVGCTMCQQSMQKSSLEFHKANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSKNKTLDPLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS", "function": "Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.", "AFDB_id": "AF-Q6GPH4-F1-model_v4" }, { "swissprot_id": "Q9RTG8", "sequence": "MNNKTNNNSVLFDLADGAVRPLGFEVLEVTQQREGRDLIVLVRIDRLDEQPVTMDDLTAASRAAEAEFDRVDPIEEEYRLEFESPGGKRPLLRARHFERMIGLKAKVRSLPGRGEHNFTAPIKAVEGDTVTFEHGGEDLSVNVADIQASLAEFPDRHR", "function": "Required for maturation of 30S ribosomal subunits.", "AFDB_id": "AF-Q9RTG8-F1-model_v4" }, { "swissprot_id": "Q10335", "sequence": "MCSPSATLTHRTMTEKARTVSDLTISQAIFELSSPFLENKSQKALDTLFSAIRDHDLAPLYKYLSENPKTSASIDFDSNFLNSMIKKNEEKLAEFDKAIEDAQELNGEHEILEAMKNKADYYTNICDRERGVQLCDETFERATLTGMKIDVLFSKIRLAYVYADMRVVGQLLEKLKPLIEKGGDWERKNRLKAYQGIYLMSIRNFSGAADLLLDCMSTFSSTELLPYYDVVRYAVISGAISLDRVDVKTKIVDSPEVLAVLPQNESMSSLEACINSLYLCDYSGFFRTLADVEVNHLKCDQFLVAHYRYYVREMRRRAYAQLLESYRALSIDSMAASFGVSVDYIDRDLASFIPDNKLNCVIDRVNGVVFTNRPDEKNRQYQEVVKQGDVLLNKLQKYQATVMRGAFKV", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.", "AFDB_id": "AF-Q10335-F1-model_v4" }, { "swissprot_id": "A0A024SMV2", "sequence": "MASGNPYTLKWGIMATGGIAETFCKDLLCNPAIRGADDVRHEIVAVASSSSSKRAEEFLQRIDGAFDAKTYGSYPELVADPNVDIVYVATPHSHHFQNTMLALEAGKNVLCEKAFTVTAAQARKLVETAKAKKLFLMEAVWTRYFPLSIKIRELIAAGEIGTVFRTIADLSINANSEQGQALKFADSHRMVNPDLAGGATLDLGVYPLTWVFQTLYHLQPEEDKEAPTVVASSNKYTTGADENTAIICSFPRHNSIGIASTTMRADTDPEKDTIPAVRIQGSKGEIQVFFPTYRPLKYKVVKTNGEAQTVDCPIPGDPARKGSGHGMFWEADECARCLRDGKLESATLPWKESIVIMETMEEALRQGGVTYPELITTDVYDPKSPLNTGNQ", "function": "NADP-dependent D-xylose dehydrogenase catalyzing the oxydation of D-xylose into D-xylonolactone. Also displays some, albeit lower activity with D-glucose, D-galactose and L-arabinose as substrate. Probably not involved in D-xylose degradation, as it has been shown that H.jecorina assimilates D-xylose via D-xylose reductase and xylitol dehydrogenase, and it is unable to grow on D-xylonic acid as sole carbon source. May play a role in the regeneration of NADP(+) in the presence of D-xylose.", "AFDB_id": "AF-A0A024SMV2-F1-model_v4" }, { "swissprot_id": "Q12403", "sequence": "MSNLCVLFFQFFFLAQFFAEASPLTFELNKGRKECLYTLTPEIDCTISYYFAVQQGESNDFDVNYEIFAPDDKNKPIIERSGERQGEWSFIGQHKGEYAICFYGGKAHDKIVDLDFKYNCERQDDIRNERRKARKAQRNLRDSKTDPLQDSVENSIDTIERQLHVLERNIQYYKSRNTRNHHTVCSTEHRIVMFSIYGILLIIGMSCAQIAILEFIFRESRKHNV", "function": "Involved in vesicular protein trafficking.", "AFDB_id": "AF-Q12403-F1-model_v4" }, { "swissprot_id": "A1BPI0", "sequence": "MPCTRSRPSLYSLSYIKRGKTRNCLYPFWSPYAYYLYCYKYRITLREKMLPCCYRSITYKEQEDLTLRPHCCLPCSCLPYSCLPCSESLEGLQVGRSTAQEKDHSQLKELYSAGNLTVLSADPLLHQDPVQLDFHFRLTPHSSAHWHGLLCDHQLFLDIPFQALEQGNRESLTATLEYVEEKTNVDSVFVNFQSNHKDRGALLRAFSYMGFEVVRPDHPALPPWDNVIFMVYPLERDLGQPGQ", "function": "Does not possess antizyme activity. Modulates PPP1CB activity through its interaction with PPP1R16A.", "AFDB_id": "AF-A1BPI0-F1-model_v4" }, { "swissprot_id": "Q9C6C3", "sequence": "MAGFINLEDSPMFQKQVFSLEGTSDELKDRCQKLYKGVKKFMGALGEASTGVSAFADSLEEFGAGHDDPVSVSIGGPVISKFINTLRELSSYKEFLRSQVEHVLLERLTNFMTVDLQEAKESRRRFDKAVHSYDQAREKFVSLKKNTRGDIVAELEEDLENSKSAFEKSRFNLVNSLMTIEAKKKYEFLESISAIMDSHFKYFKLGYDLLSQLEPYIHQVLTYAQQSKEQSKIEQDRFAQRIQEFRTQSELDSQQASAKADPSDVGGNHVYRAIPRKNVEANSVSTADKEVTKQGYLLKRSASLRADWKRRFFVLDNHGSLYYYRNTGNKSAKSQHYYSGLGEHSSGVFGRFRTRHNRSASQGSLDCNMIDLRTSLIKLDAEDTDLRLCFRIISPQKTYTLQAENGADRMDWVNKITAAITIRLNSHFLQQSPARYLDKKNTSSGPATENLTLNQKEDYNQRLNVGDDVLTILREIPGNNTCAECNAPDPDWASLNLGVLMCIECSGVHRNLGVHISKVRSLTLDVKVWEPTILDLFRNLGNGYCNSVWEELLHHLDDDSEKGSTDTLASVSKPSSEDWFTLKEKYINGKYLEKALVVKDEREANSTASSRIWEAVQSRNIRDIYRLIVKADANIINTKFDDITDLDVYHHHHVDAPDEVKKRHDPNACQRIKNSNEARNCLQGCSLLHVACQSGDPILLELLLQFGADINMRDYHGRTPLHHCIASGNNAFAKVLLRRGARPSIEDGGGLSVLERAMEMGAITDEELFLLLAECQ", "function": "Probable GTPase-activating protein.", "AFDB_id": "AF-Q9C6C3-F1-model_v4" }, { "swissprot_id": "O82281", "sequence": "MFTCINCTKMADRGEEDEEDEARGSTTPNTKEAVKSLTTQIKDMASKFSGSHKQSKPTPGSSSSNLRKFPDFDTASESVPYPYPGGSTSSTPAWDLPRSSYHQSGRPDSRFTSMYGGERESISAQSCDVVLEDDEPKEWMAQVEPGVHITFVSLPSGGNDLKRIRFSREVFDKWQAQRWWGENYDRIVELYNVQRFNRQALQTPGRSEDQSQRDSTYTRIDSARESRDWTQRDNNFRPPGGSVPHHFYGPPMDAARITTSSRDEPPSMSNASEMQGEWVEEDEPGVYITIRQLPDGTRELRRVRFSRERFGEVHAKTWWEQNRDRIQTQYL", "function": "May act as a regulator of cell proliferation and elongation in the root.", "AFDB_id": "AF-O82281-F1-model_v4" }, { "swissprot_id": "Q96326", "sequence": "MAARLLFRRSSQILRSIQRNPQISSSFESPPCPIFHSLTTASPDPSRLSSLTFLRSLSIARRGPTRPKKIDIGAKARQMQNRRLWTYALTFSCIAGFVVIVLNQFQDQLVFYLTPSDAMEKFAENPTKNKFRLGGLVLEGSVAQPAASQEMEFVITDLITDILVRYKGSLPDLFREGHSVVVEGFIKPYTDEVRKEVSTKPISKKARNLDCFFSATEVLAKHDEKYMPQEVAAAIEKNKKIIEAAATEQAAEVAAS", "function": "Heme-binding chaperone that may be involved in cytochrome c maturation in mitochondria.", "AFDB_id": "AF-Q96326-F1-model_v4" }, { "swissprot_id": "Q8P4G1", "sequence": "MMAAETAAAGVASRLAAARILAAVFDQGRSLKAELTAALPGVSDPRDRALVEAICFAVLRRRPAYDVALRQWLERPLPPRDAELKALLMAGFAQLDVLQLPAHAALSATVEACRALGRPRQAGMVNAVLRRAQREGFPAVADDAGWPSWLRKQLRADWGDQAEAIFVESARMAPMWLRVPRARVSPAEYVARLAEQGITAHTDPVLADAVRLDTAVPVSQLPGFAQGDVSVQDGSAQQVADALALAPAARVLDACAAPGGKAAHLLERHPQLQLTALDVDARRLERVRQTVQRTAPDRTVRLHPADAADTAAWWDGQPFDAVLLDAPCSATGVVRRQPDVLLHRRADDIDALCALQARLLEACWRTLRPGGQLLYTTCSLLKRENQTQIEAFLQRTADAQAQPLGAQFGHAAGAGRQRFPGEQQCDGFFYALLLKAS", "function": "Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.", "AFDB_id": "AF-Q8P4G1-F1-model_v4" }, { "swissprot_id": "O75175", "sequence": "MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPAASALSTTPGNNGVPAPAAPPSALGPKASPAPSHNSGTPAPYAQAVAPPAPSGPSTTQPRPPSVQPSGGGGGGSGGGGSSSSSNSSAGGGAGKQNGATSYSSVVADSPAEVALSSSGGNNASSQALGPPSGPHNPPPSTSKEPSAAAPTGAGGVAPGSGNNSGGPSLLVPLPVNPPSSPTPSFSDAKAAGALLNGPPQFSTAPEIKAPEPLSSLKSMAERAAISSGIEDPVPTLHLTERDIILSSTSAPPASAQPPLQLSEVNIPLSLGVCPLGPVPLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDLQ", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.", "AFDB_id": "AF-O75175-F1-model_v4" }, { "swissprot_id": "O50917", "sequence": "MIKCNNKTFNNLLKLTILVNLLISCGLTGATKIRLERSAKDITDEIDAIKKDAALKGVNFDAFKDKKTGSGVSENPFILEAKVRATTVAEKFVIAIEEEATKLKETGSSGEFSAMYDLMFEVSKPLQKLGIQEMTKTVSDAAEENPPTTAQGVLEIAKKMREKLQRVHTKNYCTLKKKENSTFTDEKCKNN", "function": "Binds to decorin which may mediate the adherence of B.burgdorferi to collagen fibers in skin and other tissues.", "AFDB_id": "AF-O50917-F1-model_v4" }, { "swissprot_id": "O31779", "sequence": "MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVSTIVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLLQLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL", "function": "May work together with YlbF to regulate community development.", "AFDB_id": "AF-O31779-F1-model_v4" }, { "swissprot_id": "Q17020", "sequence": "MKLLILAVAISLAVLASGSYVPSTKFEAKYADKEFLFKQKFFFEVLRNIHLPLKYDEYIPYTKTWVSDETKYNDFAQVAEFFDYYKTGAFLEKGELFSIYNEQYLRQTYAVFTFLYNSADWDTYYKNMIWARDNINEGMFIYVLHLTVMHRPDLQGIVLPAIYEIYPYYFFNTDVIRTINYKKLYDPKFGFYGNGKYNVVYANYTATYPMDYYNNFYTEEYLNYYTEDIGLNACYYYFMMDYSFLLGGDKFGLIKDRRGELYWYMHQMLLARYNLERMSNYMGTVKPLVWRFPLKTGYFSLLSYWNGVPFKSRDYNYMISDESYFKLDWINAWEAKIRKIIEDGFFVKEDGTRINLRLPESVEFFGNLLNSNVDSVDANYVGYIEVFSRLLLSGNDFNAYKVWPSALMQFETSLRDPVFYQLYERFMDLYYYFKRFLPSYTYEELNFNGVVIKDVTFDKLMTYFDYFDSDVSNVLPMQSTDKYFDYAVFARQRRLNHKPFSYTMNVMSDYTGKAIIRAFVGPKFDRFFDLQFYKKYFFEIDQYLVDFTAGKNTFVRNSRDFYWSVKDRTMYTDLYKKIMLGYNGQEKFALDMSEAHCGFPDRLILPKGWTSGMPMQFYFIITPYTAKTYEQGYQYDKTFTCGVESGMRFYDSLPFGYPFDRVINFNYFYTKNMYFKDVFIFHTEEMKMNQRY", "function": "Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.", "AFDB_id": "AF-Q17020-F1-model_v4" }, { "swissprot_id": "P9WGF2", "sequence": "MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGEQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVSIDNSDNALPIEYTEVSITRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLEEILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDTMAANLARLTDLTTELRRQLKPLGRQAEAAQRAAAIQADLRDARLRLAADDLVSRRAEREAVFQAEAAMRREHDEAAARLAVASEELAAHESAVAELSTRAESIQHTWFGLSALAERVDATVRIASERAHHLDIEPVAVSDTDPRKPEELEAEAQQVAVAEQQLLAELDAARARLDAARAELADRERRAAEADRAHLAAVREEADRREGLARLAGQVETMRARVESIDESVARLSERIEDAAMRAQQTRAEFETVQGRIGELDQGEVGLDEHHERTVAALRLADERVAELQSAERAAERQVASLRARIDALAVGLQRKDGAAWLAHNRSGAGLFGSIAQLVKVRSGYEAALAAALGPAADALAVDGLTAAGSAVSALKQADGGRAVLVLSDWPAPQAPQSASGEMLPSGAQWALDLVESPPQLVGAMIAMLSGVAVVNDLTEAMGLVEIRPELRAVTVDGDLVGAGWVSGGSDRKLSTLEVTSEIDKARSELAAAEALAAQLNAALAGALTEQSARQDAAEQALAALNESDTAISAMYEQLGRLGQEARAAEEEWNRLLQQRTEQEAVRTQTLDDVIQLETQLRKAQETQRVQVAQPIDRQAISAAADRARGVEVEARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQARAARLHAAAVAAAVADCGRLLAGRLHRAVDGASQLRDASAAQRQQRLAAMAAVRDEVNTLSARVGELTDSLHRDELANAQAALRIEQLEQMVLEQFGMAPADLITEYGPHVALPPTELEMAEFEQARERGEQVIAPAPMPFDRVTQERRAKRAERALAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVADVDARILQVFNDAFVDVEREFRGVFTALFPGGEGRLRLTEPDDMLTTGIEVEARPPGKKITRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDVNLRRLLSLFEQLREQSQIIIITHQKPTMEVADALYGVTMQNDGITAVISQRMRGQQVDQLVTNSS", "function": "Required for chromosome condensation and partitioning.", "AFDB_id": "AF-P9WGF2-F1-model_v4" }, { "swissprot_id": "Q23697", "sequence": "MLASQAGSNFSAAASSNGGQQQQQRRQHPIRPLTIKQMLEAQSVGGGVMVVDGREVTQATVVGRVVGYENANMASGGGAITAKHFGYRITDNTGMIVVRQWIDADRAQEPIPLNTHVRASGTVNVWQQSPIVTGTVVSMADSNEMNYHMLDAILTHLRLTQGNKRAAGNIGSGASVQNSAAAVGVQNMLPGGDNKVLLTDLLVSFIKQNGHGDAGMSMDELTMAAQRYSFTPGDVRTAMRTLAAEGKVYQTHDNRFNI", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.", "AFDB_id": "AF-Q23697-F1-model_v4" }, { "swissprot_id": "A5H8G4", "sequence": "MAKESKLTAGVAAALTVVAACALCLLLPATARAQLRVGFYDTSCPNAEALVRQAVAAAFAKDAGIAAGLIRLHFHDCFVRGCDGSVLLTVNPGGGQTERDALPNNPSLRGFDVIDAAKTAVEQSCPRTVSCADIVAFAARDSISLTGSVSYQVPAGRRDGRVSNATETVDLPPPTSTAQSLTDLFKAKELSVEDMVVLSGAHTVGRSFCASFFKRVWNTSTNPATAIVDAGLSPSYAQLLRALCPSNTTQTTPITTAMDPGTPNVLDNNYYKLLPRGMGLFFSDNQLRVNPQMAALVSSFASNETLWKEKFAAAMVKMGRIQVQTGTCGEVRLNCGVVNPSLYSSSSAVELGSSAPAAVGEEGYAAS", "function": "Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.", "AFDB_id": "AF-A5H8G4-F1-model_v4" }, { "swissprot_id": "Q7Z020", "sequence": "MTSGDKETPKREDFASALRFLMGGCAREPEMTAMAPLNLPKKWARILRMSSTPKIPIVDYLEAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVIDIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRNPLQLAAMSGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAIDYAIYYKYPEAALAMVTHEERANEVMALRSDKHPCVTLALIASMPKVFEAVQDKCITKANCKKDSKSFYIKYSFAFLQCPFMFAKIDEKTGESITTASPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWNSYGKYFHLANLLIYSIFLVFVTIYSSLMMNNIELKAGDNKTMSQYCNMGWEQLTMNLSQNPSVASQIRLDSCEERINRTTAILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVLYISALVMVTPAFQPDGGINTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIKVLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQRVDKMELIEYPNETKCKLGFCDFILRKWFSNPFTEDSSMDVISFDNNDDYINAELERQRRKLRDISRMLEQQHHLVRLIVQKMEIKTEADDVDEGISPNELRSVVGLRSAGGNRWNSPRVRNKLRAALSFNKSM", "function": "Essential for thermotaxis by sensing environmental temperature. Receptor-activated non-selective cation channel involved in detection of sensations such as temperature. Involved in heat nociception by being activated by warm temperature of about 24-29 degrees Celsius.", "AFDB_id": "AF-Q7Z020-F1-model_v4" }, { "swissprot_id": "Q9VPW8", "sequence": "MKTGSNNNHISASSSSSNNNNNSSLVQQQQQRSTTSVSVSSSHIVTEWEDGIIFDVDDPDFCNLATDKLNFIVPSAANMSIASVHGPQIADICSPLSHHNLGLSASLPDLVGSPLEISMDNVLTIEELRQHMGSCFTCGVSWTDDHVSLDCSECGGYSLERPCPLCDGQCGVQWKRDFAMSHACSQARWVGVCISYPEVVAGVQLPVGAGAGAATSCAAAAANQLRLAQELCSRLEQLSTSTASKSGRI", "function": "Plays a role in olfaction.", "AFDB_id": "AF-Q9VPW8-F1-model_v4" }, { "swissprot_id": "P13479", "sequence": "MELKHSISDYTEAEFLQLVTTICNADTSSEEELVKLVTHFEEMTEHPSGSDLIYYPKEGDDDSPSGIVNTVKQWRAANGKSGFKQG", "function": "This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.", "AFDB_id": "AF-P13479-F1-model_v4" }, { "swissprot_id": "P29709", "sequence": "MATFKLEVVTPLKKVLDRDAEMVIMRTIEGDMGVMADHAPFVAELAVGEMKIKSANGEEAYFVSGGFLEISKEKTMILADEAIDVKEIDVERAKREAEIAKETLVKLKEDKDIAVTQKSLQEALTKVRIAEQYMHHL", "function": "Produces ATP from ADP in the presence of a sodium gradient across the membrane.", "AFDB_id": "AF-P29709-F1-model_v4" }, { "swissprot_id": "P25632", "sequence": "MVTQTNPVPVTYPTDAYIPTYLPDDKVSNLADLKKLIEMDSRLDLYLTRRRLDTSINLPTNTKTKDHPPNKEMLRIYVYNTTESSPRSDSGTPADSGKTTWTLRIEGKLLHESANGKHPFSEFLEGVAVDFKRLKPLGMGKKRKRDSSLSLPLNLQQPEYNDQDSTMGDNDNGEDEDSAEAESREEIVDALEWNYDENNVVEFDGIDIKRQGKDNLRCSITIQLRGVDGGKVQYSPNLATLIGMQTGSVNDAVYSIYKYILINNLFVTEQTEAQDGSNDAEDSSNENNNKNGAGDDDGVEGSTPKDKPELGEVKLDSLLQKVLDTNAAHLPLMNVVQTVNKLVSPLPPIILDYTIDLSKDTTYGATTLDVDVSHILHQPQPQPNLQKEEETDAEDTAKLREITKLALQLNSSAQKYQFFHELSLHPRETLTHYLWSSKQNELVLQGDQYFNEDAARTSDIYSNNNNDRSLMGNISLLYSQGRL", "function": "Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.", "AFDB_id": "AF-P25632-F1-model_v4" }, { "swissprot_id": "P45995", "sequence": "MNKKSYINHYLTLFKVTTLLFTLSSNPVWANIKTVQGTTSGFPLLTRTFTFNGNLQWNVSALQPAYIVSSQARDNLDTVHIQSSEINAPTNSLAPFNNWINTKSAVELGYSFAGITCTSNPCPTMKLPLLFHPDLTNLTPPGKKNSDGGEIFKLHNESNLGVSFQIGVKTNTSLDWVNAKNNFSSLKVLMVPFNSSDKISLHLRAKFHLLTDFSSLNNDITIDPMNTSIGKINLETWRGSTGNFSVKYVGEDKGDISIFFNTPKIILKKQQRRCTLNNAPVSPNPVKLRAVKKRELEAQSEMEGGTFQLRVNCDNTTYNKANGKWLFPVVKVTFTDEDGTTNNGTNDLLRTQTGSGQATGVSLRIKRENGTETVKYGADSAQMGNAGQFELRKQPSPAGGDQYAEETFKVYYVKDSTRGTLIEGKVKAAATFTMSYQ", "function": "May be a minor structural protein required for pilus biogenesis. May be the adhesive component in the pili.", "AFDB_id": "AF-P45995-F1-model_v4" }, { "swissprot_id": "O94559", "sequence": "MQPRFLLHGALLALGIQLCLSIGKITGHISSIEATAADIHDAPSTTTKYVQRTVYAGREKGKIGGPADSWPQRKLDDFLQNHGVKSLDVPPIETPSQFWRKPLQYVSKVTDKCKSFYEKEKNHASHNAQKLDVWIFNSWTNSELSRWLIKNKYEVPEPGTREQLLETVFQASMGDAISTNDELESWSNNLLLSMLDQKNITVPIGASHDDLIVLARRYYDIEERKSQDKVTNITDSQPAPYMKEIIHLWSDGRLIDFLRERNIPISVLSPRETLLKEAYANRFTPRVMIASNVLDGWSSEDLLDWIWKYNKRGSIFSHVAYNSRHELIHAAKLFYMDVASEWSSSDMASLNDSLYSHPSVSKQSTWTEEELKEELESFGELVPVPFSSTKAFERLLPHLYYYLRGPAFLNRIHYWQTFLGNSLKRAFVLSQ", "function": "Inner nuclear envelope protein involved in nuclear fission, which is achieved via local disassembly of nuclear pores within the narrow bridge that links segregating daughter nuclei. Les1 restricts the process of local nuclear envelope breakdown to the bridge midzone to prevent the leakage of material from daughter nuclei during mitosis.", "AFDB_id": "AF-O94559-F1-model_v4" }, { "swissprot_id": "Q9XIE0", "sequence": "MSFLFRKNGSSSRRKIKEKLRGRHSDRGGKREEDERYGGSGSDLPPPPSPWGFLFPEDFVRIDGNLKAVIVDDEGLDVIYWKKLLELENSGKIRKNPKPRRRGDKSGDGFRRTGADQDDNDDGDDEVGDESIEEAFSFHVKKSQSASSSGGEIRDQSNNGGGGGGGGGGGGRYYTSSSASPSRPSSSSASAASPSRTSYATSAGSDYGGGGGGKQSQSKFQAPGGGSFPSSPSQIHSGGGRSPPLPLPPGQFTAGNASFPSSTQPPPGQYMAGNASFPSSTPPPPGQYMAGNAPFSSSTPLPPGQYPAVNAQLSTSAPSVPLPPGQYTAVNAPFSTSTQPVSLPPGQYMPGNAALSASTPLTPGQFTTANAPPAPPGPANQTSPPPPPPPSAAAPPPPPPPKKGPAAPPPPPPPGKKGAGPPPPPPMSKKGPPKPPGNPKGPTKSGETSLAVGKTEDPTQPKLKPLHWDKMNPDASRSMVWHKIDGGSFNFDGDLMEALFGYVARKPSESNSVPQNQTVSNSVPHNQTYILDPRKSQNKAIVLKSLGMTKEEIIDLLTEGHDAESDTLEKLAGIAPTPEEQTEIIDFDGEPMTLAYADSLLFHILKAVPSAFNRFNVMLFKINYGSEVAQQKGSLLTLESACNELRARGLFMKLLEAILKAGNRMNAGTARGNAQAFNLTALRKLSDVKSVDAKTTLLHFVVEEVVRSEGKRAAMNKNMMSSDNGSGENADMSREEQEIEFIKMGLPIIGGLSSEFTNVKKAAGIDYDSFVATTLALGTRVKETKRLLDQSKGKEDGCLTKLRSFFESAEEELKVITEEQLRIMELVKKTTNYYQAGALKERNLFQLFVIIRDFLGMVDNACSEIARNQRKQQQQRPATTVAGASSSPAETPSVAAAPQRNAVRFPILPPNFMSESSRYSSSSDSDSES", "function": "Might be involved in the organization and polarity of the actin cytoskeleton.", "AFDB_id": "AF-Q9XIE0-F1-model_v4" }, { "swissprot_id": "P40856", "sequence": "MSGSFWKFGQDFGSQSPLAKLLNRAFIKIDDKPTSTEAGKIDSNSTDESLESNSFKSEDEEEEYELPNREEDYKAYKPNLSLLNDLLDDEELYTELMCSNFKLLVYLKYPEVLSKLIDYVRNSTILESNIDRVTSEDRDLVRGEDKDTTEDFENAKADKKNIDGTFEEKERTRSGEEEELENEENDSASEDTRVTLPHELEEHDDTRRARIAAEILSADVWPISSALIENEGLLAKLWSILRLPSPLSIEASTYFMKINERLLDMNMDGIIEFILKKEHIVDDFLAHIDNPPLMDFLLKVISTDKPEISNGVIQLFKKQNLVPKLIHLLDPVFDSCTQSAAGDFLKALVTISGNCPNEITSSIGPNELTRQLVSPNMMKQLMDIMLKGGNSLNNGVGIIIELIRKNNSDYDTIQTNYTTIESHPPTDRDPIYLGYLVKMFSEHMADFNKILTEKKIPLLQTSYGTIEPLGFERFKICELIAELLHCSNMTLLNEPSAYDIVRERDAERERIFNSQNYVDSNDRSELKENEDDNTGDADDEVEDDTNQVESANTSIDGEEVIDKLNSLQIETNKVNQNMNNEEQHSLMPDFNNGDFKDEEDENPFEPQYSDVILDSSDIEKNFRVSPNVGDQLKISLQDTRVIDTMLEMFFHFQWNNFLHNVVYDVVQQIFNGPLKIGYNRFLLDDLLINIRLTDMIINGNNECIEYEKGHDTRLGYMGHLTLIAEEVTKFTAYIEEMNITFENTEVMSSLFESKWIAYTEDVLEDLKEKYNAILGDIAEEGDMLQDEEEDAVYDKGERTMGTVDDYINDIMQMDNVRCQEEEEDEGEGYVSFDEDEPQEYRNGDSVRSKESNSSEGKRDQEQLYYEYVNEDGTKTRLNFNPDSDATEQVPGEVNRDHKIPLKLKRSFTDACKSETIPNNTVNAKEESVFQFSNELSDGWESSPSNSIPKRASPSKNGMNSPMFQHQFELHSPTDEFGGHKDEILSAEGHDYDIDEYDELSDDSDEEYDNCEDEDSLDYADSAAYALCRSKSKDKISWDEEEQARLMGVVKFNSEHYRD", "function": "Associates with the SIT4 phosphatase in a cell cycle dependent manner. May be directly or indirectly involved in SIT4-dependent functions in budding and in normal G1 cyclin expression.", "AFDB_id": "AF-P40856-F1-model_v4" }, { "swissprot_id": "A0A0M4LAF6", "sequence": "MCRFVDAIKSLLDESDITTLVALANRLSPFRVDYRRVVVGDALSVKPILVLEHEQPPCDGAWRSAAHINLGLGAAQQQHHPVPTRAVHGAAVGGVQCDGLASPPVSNNVMSDGTVDGDDDDLGYDQDTLYNQGTDYENEGGAVGQDGLPAPDAGLFQECMFSHRSASTPRAGGHGESYCQEVAQSSHAITCRELLERCILPNFEINHLENCESSTSGGIHHCLPDEHSGMTGLARNTPSASPVENSITVELDGALEIATDVRTGKFNTLRAAKRHRRNTSSLRLSSHDAGCVGDARSSAGVVKSPARRSTAVSDAALRKVKYAARTCIRADYFQFLEANLPRWVRDGIWGKEWSPNQTANVDGYENLQKAYWHVCRLDRQMRDDAIRSRMAMVLLHLEYENTCLSWKTCAHSGKKPVTKVGRGNISSLIDNIIENTHPEWRTADPGERSELRAKFHDRKRYGKRWWMLVKPLGSSILMLCSSKFAGMIKNTTVTAAMINEIKLAIQRSETGLMSLLSLANPIAESLFLDQGYDGHNAEQVLKALRAARLEVAPGEGVA", "function": "Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of aurovertins, fungal polyketides that exhibit potent inhibition of adenosine triphosphate synthase.", "AFDB_id": "AF-A0A0M4LAF6-F1-model_v4" }, { "swissprot_id": "Q59LX5", "sequence": "MNRSSYSSQSDNRYSRNPAVLCSFYSKIGACRHGEKCSKKHLKPISSRTILLANLYQNPTLNDDDYGHANGIGSETSQIIDNESVIKNSDTVGTVSQIDDSPHSNSGEVTKDETVETQEVETENSENIAETGDVKIDHNEDQKQIEDVKESDKVESSEEVQQDDKLHKEDTLEKESEDNIKQDENIEDAKLEDTEKDKLPEFTISQSQKDFDQFFQDIFVHISKLGQIRDIAVCENENNHLAGNVYVMFESAEDAYNANLQLNQEWYNGKPVYSDLSPVNDFNDACCEEYRDYHDCQRGAMCNYMHVRLPSSDIEESLYESQAKSYMLKQLEELKKELPGDIRSSSSTNDDETNGNENGISSTMAVLEQLS", "function": "Transcription factor required for yeast cell adherence to silicone substrate.", "AFDB_id": "AF-Q59LX5-F1-model_v4" }, { "swissprot_id": "Q9LHS9", "sequence": "MMDRGECLMSMKLRPMVTRPSSDGTLFWPFREERAFASAEEYGGGGGCMWPPRSYSCSFCGREFKSAQALGGHMNVHRRDRARLKQQSLSPSSTDQATPPECDRQQQVLDVGSKVLVQEETRKPNGTKREISDVCNNNVLESSMKRYEHDNGEVKTDLSVGLLSTEFDPRKKQLINGSSSSWKRAKTDVSRFPMMLGLVIGISEINGHHEELDLELRLGADPPKVN", "function": "Probable transcriptional regulator essential for petal development. Required for the early development of the organ primordia of the second whorl. Acts downstream of AP1 and PTL.", "AFDB_id": "AF-Q9LHS9-F1-model_v4" }, { "swissprot_id": "Q06011", "sequence": "MDWLKNTTIVVLFSHSTDKSNKHKKRQVQCNMRKNTLDMVTIGIACLVGVYTGTRFFEPIVIDRLRKDGNLRTDIPIPEYDEDGNLLKVTPSLSSTPAAPPTPPTPPTPPQQ", "function": "May be involved in cell wall organization and biogenesis.", "AFDB_id": "AF-Q06011-F1-model_v4" }, { "swissprot_id": "Q1IHH4", "sequence": "MAEKKIAFRNRQDFSKIPATIQIPNLIEVQKRSYDRFLQMDLLPSERDDAGLQAVFQSVFPITDFRNVSQLEFVDYAIGNWECKCGHLKGLHHLRTTCKNCGATVVTDPFHPGDVLCHKCGTFNANTPDFCNKCGDPVGLQLKYDVAECEERGMTYSAPLKVTMRLTIFDKDPETNNRTIRDIKEQEVFFGDVPLMTQNGTFIINGTERVIVSQLHRSPGVFFETANNRTYFLGKIIPYRGSWVEFEYDQKNILYVRIDRKRKFLGTIFLRALGLRTDEDILRTFYTVDRIAVKDKKLYWTLEPGIERPTNLVGLKLSHAIKAKNGEEVAHSGRKVTASVLKEIQKHKISELEIELGDLEGAYVASDVIDTNTGEVLLEANQELTADKLSKMIDAGIGEVNVFFPERDDVGTVISATLRRDSVKTPQEALIEIYRKLRPGDPPTLDTATALFHGMFFDARKYDFSRVGRLKFNIKLFDRQDPTGLDKRTLDPDDFYHTIRYLLKLRRNLGAVDDIDHLGNRRVRAVGELLENQFRIGLVRMERAIKEKMSVYQEMSTAMPHDLVNAKPVMAAIREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLSRERAGFEVRDVHPTHYGRICPIETPEGPNIGLISSLSCYARINDYGFIESPYRRVKGGRVIDYVQVTHAGDSDYRVGDKMEKSEAQKANEELRGRKKRGIELEPYSFYLSAWEEDKWTIAQANAELDEKGKITSELVNARKAGNFVLISRDDIDYIDVSPKQLVSVAASLVPFLEHDDANRALMGANMQRQSVPLLRAEAPIVGTGMEGVTARDSGAVVLARRSGIIDSVDSERVIVRVEGEHHPMQLSREVGSDIYQLTKFKRSNQNTCINQKPIVKQGDHVKKGQVIADGPCTDHGELGLGRNVLVSFMPWRGYNFEDAILVSEKLVKEDYYTSVHIEEFEIEARDTKLGPEEITRDIPNVSESALRDLDESGVIRIGAPVKAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAGDVRDASLTCPPGIEGVVVDVKIFSRKGQEKDERAKQIEGTQIAKLEKNLADEIRILTDERLKRLEGLLGAKVVQADLHDERTNKRLLTKDAVLDRETIERISTRNLKRIKYADKDPRVNEQIDEIEEMTSRQIDVLRKIVREKIEKLQKGDELPPGVIKLVKVYIAMKRKLSVGDKMAGRHGNKGVIARILPEEDMPYLEDGTPVEIVLNPLGVPSRMNVGQILETHLGWAGHELGKKIAEFMVENSEAGQVRKHLKQLFKDTAFVDHVTELDDEMLLKVAKGMQDGVFFGSAVFDGSTEAEIKSLLDQAGLPTSGKTFLYDGMTGDRFEQPVTVGYIYMLKLSHLVDDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYILQELLTAKSDDVYGRTKIYEAIVKGEAAIEPGVPESFNVLIRELQSLCLDVELIKTKEKAAPAPVAAD", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "AFDB_id": "AF-Q1IHH4-F1-model_v4" }, { "swissprot_id": "P0CP45", "sequence": "MSQDPILTSKGSQEEEDFFGLDNFFPEPESPLPPPFSFASYDIPANIDFYVPDHRKSLILRLVGSHPLWGHHLWNTARTLSTYLLETPQITQSRHVLELGAGAGLPSIVCVLAGSSKVIVTDYSDEGLLDNLRFNVDVNLEGEEKERIAVDGHVWGQSVDPLLGHLPKGQKYDLLILSDLVFNHSQHDALIKTVEATLTSSSTQSYDPSNPSAPLTEPSILVFFTHHRPHLAHADMAFFPRLAESGNGWAYEKVVEEWAGAMFENDPGDKKVRGTVHGWRAWRVRDGEERGEKPSRISL", "function": "S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.", "AFDB_id": "AF-P0CP45-F1-model_v4" }, { "swissprot_id": "P26587", "sequence": "MATSARRAYGFGRADEATHPDSIRATLAEFLSTFVFVFAAEGSILSLDKLYWEHAAHAGTNTPGGLILVALAHAFALFAAVSAAINVSGGHVNPAVTFGALVGGRVTAIRAIYYWIAQLLGAILACLLLRLTTNGMRPVGFRLASGVGAVNGLVLEIILTFGLVYVVYSTLIDPKRGSLGIIAPLAIGLIVGANILVGGPFSGASMNPARAFGPALVGWRWHDHWIYWVGPFIGSALAALIYEYMVIPTEPPTHHAHGVHQPLAPEDY", "function": "Water channel required to facilitate the transport of water from the vacuolar compartment to the cytoplasm.", "AFDB_id": "AF-P26587-F1-model_v4" }, { "swissprot_id": "Q5AV07", "sequence": "MFNFPHPAIDLASRMKSSPLMAGGSSSASSEDLFSPPMMEDLDTPMTEYPMGSPPRMPYRGEDIEIAFLRSEASIKKSSLFNDKFAATLDDLSARPIDSASLIGKLQSMTRSVREILDSGDQLVHEDGPQEILKQFVRVVNKHLCQDEDIHTVLAPLALEPEEKFHIIQTYYQAISMTQFVSPKWTSSLLSDALCRRANIVTVFNGQGVEGYFSELQHLYDTYGGLLAEPLYALSKQLKGLASDVRAQDMYPHGLDVIGWLENPEARPSTDYLLSAPVSQPLIGLVQLLNYAITCKILNKSPGEFARHLSGSAGHSQGIVVAAMLATVVSWPTFFDAASTALQVLFWIGCRSQQCYPSHSIPPSLVDQSERLSPMLSVKGASRESLLKYLDEHNRHLPPAQQGSLALINGRQQFVVAGNPLSLYAFANKLRAASNNSSTTNTARVPFSQRPLLITARFLPISVPFHTSLLEDAEAQILEDLRSVHVPGNSLLFPVLRTDNGADLREFDNLVPELVHMVVCGVVDWDRATRFPTATHLLDFGPGRETGIGALLASTKAGTAARVILSTTLTGPSKKTLGYMPELLSRRRPVVYNTSWEQDFAPRLVRVGDDILLDTKFSRALGLPPVMVAGMTPTTVSPDFVAEVINANYHIEIAGGGYHDAAGMRSALTRLVNLIPAGRGITVNLIYANPRAMGWQIPLLVQLRQEGLPITGLTIGAGVPSPDIASEYIRDLGLSHISFKPGSKEAIDNVLRIAESNPGFPIILQWTGGRAGGHHSYEDFHEPILDRYAQIRAYPNLILVAGSGFGGSDDTIPYITGSWSKKLGYAAMPFDGVLVGSRVMTAKEARTSPAVKQAIVDTPGVPDSQWEGTYKKATGGIITVKSEMGEPIHKLATRGVLLWAELDKEVFSLPAAQQVQELQRRKGSLMKRLNADFQKVWFGIDQQGNPVEISEMTYAEVLTRAVDLLYLKDQQAWIDPSYRSFVADFIRCVENRLSARQPRPRAVFQSALQLDRPQVFLSEFLQAYPAALEDVIVREDEDQLVKLYKQPGRKPLPFIVALDESFEYWFKKDSLWQSERLEAVTNQDVGRICILHGPVAAQYTKVANEPVKQILDNIHKPHVQAILKQQYAGDTSRVPTLDYLYSAGAVSPMLSPQDELLLPHVKHSRSYDPPTLAYDLEGPEENLPTEKQWLALIGGTKPSWRKALLTLNEIVQGKMLVENPIKGLFAPRAGLSVRIIQAGRPQKTVILMRQKSSQGQEKDEATVEIRALSTSEIMLTLRAPMTGGSAGNPPVDLVLYFTYKPTYGNNPIHEVMGTRNQRISRFYEQLWVGNAGDEGTSLQKSADDVQVLTREAILNFTKAIDNRNSAYNGKKNSKLLAPLDMAIVVAWKPLMRCLFTDAVNGDILKLLHLKNDFRVIDNASPMREGDVLSSTAAIESIRIRPDSGKVVRAVATIFKKGTPIITVASEFILQGRYEDYHNTFETKEEQVYKLPLKSKRDVVLLASKPWFRIAAADLSLDDHLDDELTFRLKSSYHFRDANTYSQIETCGTVSCAVGNKDMTIGTVMFKSNSHFLKNPVIDFLTRRGFAYDEVKQLPNAVPLAADVRIEMPTSSDQYAAASGDSNPIHLSRAFARYAGHNEGRVIHGMQTSGLVRGVVELHAAGNDPRRMKAWSASFKGKVSPGETLLVDISHTGMNNGRLIVVATARSESSSVEVFRATAEVAQKPGAYLFTGQGSQKPAMGMDLYETSQAARDVWHTAEQFFVNTYGISILEIVRNNPKEYTVHFGGSRGKAIRENYISLDFEVVNEQGEIESVRAFQEITPSSRSFTYTSSGGLLHETIFTQPALVVMELARFHDMRARGLINEDSCYAGHSLGEYAALAAMGEVFTVEGVTAAVFYRGLTMQKSIELDRSGRDYSMVAANPSRVSKNLSESDLCAIVDSIEAATGGLCEIVNFNVESTQYVCAGDLRSLDCLAGVLDSLVAHPEHLTSLETLNASVPAIVASCLAQTDKKPTPLVLQRGKATIPLKVNVPFHSSLLRPGADTFRRALRKAIPEHMVRPEKLIGRYIPNLTAMPFELSKGYFENVLAISESPFVREILERWDDNNVAVAVC", "function": "Fatty acid synthase beta subunit; part of the gene cluster that mediates the biosynthesis of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol). The core structure of aspercryptins is as follows: Ser/Ala-Thr-Ile/Val-2aoa-Asn-2adol. The first step of aspercryptin biosynthesis is the generation of the fatty acid precursors, octanoic and dodecanoic acids, by the FAS subunits atnF and atnM. The fatty acid precursors are likely transformed into the corresponding alpha-amino fatty acids in three steps. First, they are hydroxylated by the cytochrome P450 monooxygenase atnE, then oxidized to the corresponding alpha-keto acids by the NAD(P)-dependent oxidoreductase atnD, and finally converted to the alpha-amino fatty acids by the PLP-dependent aminotransferases atnH or atnJ. the alpha-amino fatty acids, 2-amino-octanoic and 2-amino-dodecanoic acids, are recognized, activated, and covalently tethered to the NRPS atnA by its fourth and sixth adenylation domains. The second module of atnA is the Thr module and contains an epimerase (E) domain responsible for the epimerization of Thr to D-allo-Thr. Additionally, despite atnA having only one epimerase domain, the first amino acid of aspercryptin A1 is D-Ser, suggesting that serine is either loaded directly as D-Ser on the first module or that the epimerase domain in the threonine module epimerizes both L-Ser and L-Thr. After condensation of the hexapeptide of aspercryptin, the C-terminal reductase (TE) domain might be involved in the reductive release and production of the aldehyde hexapeptide. Further reduction would generate aspercryptins. The variety of aspercryptins produced reflects the flexibiliy of the atnA NRPS, allowing incorporation of alanine instead of serine, valine for isoleucine, and a C10 fatty amino alcohol instead of the C12 version. AtnB seems to be involved in the selectivity for Ile versus Val by the third module. Moreover, type B, C and D aspercryptins have an additional N-terminal cichorine, acetyl and propionyl group respectively.", "AFDB_id": "AF-Q5AV07-F1-model_v4" }, { "swissprot_id": "Q45489", "sequence": "MSEDQYKQIKLHLGMEDDNEDLPNHIPSSFPKQHLNKIYNGDTMNMLLDIPDNSVDLVVTSPPYNINKFKNDRRPLEEYLKWQTEIIEQCHRVLKPSGSIFWQVGTYVNDSGAHIPLDIRFFPIFESLGMFPRNRIVWVRPHGLHANKKFAGRHETILWFTKTPEYKFFLDPIRVPQKYANKKHYKGDKKGELSGDPLGKNPGDVWAFRNVRHNHEEDTIHPTQYPEDMIERIVLSTTEPNDIVLDPFIGMGTTASVAKNLNRYFYGAEIEKEYVDIAYQILSGEPDENNNFPNLKTLRQYCEKNGIIDPSQYTFTRQRKGSKPSLDSKAHPEEHHKKEIVERIEFEAENSVYKKVQNEQ", "function": "A beta subtype methylase, recognizes the double-stranded sequence 5'-AGATCT-3', methylates C-5 on both strands, and protects the DNA from cleavage by the BglII endonuclease.", "AFDB_id": "AF-Q45489-F1-model_v4" }, { "swissprot_id": "Q4P996", "sequence": "MSFHPNAVDAPPSYLHQHQAGSPLYTQNTIRPNANSTDLNSPHKPPILQPWLGLQARLFLAPISIPLISLLFVAARMLSSSNEATDSISSAKGKLLSACSAAEGTASLAASFPHFLAASTNVQLALSVTATVHSAARVFDLSMTAIQKILTYIVNSYKSLFMCFMELLVRGALAVLITAVEFISQAITAATLGIRSAIQESITGVNTLLATAVGAINDVIGVFGQHVNPPHIAVPSLTSLENITLPHEIQDGLVKLNATLPTLQQLKQSMDALIETPFEEMKREVNATLASFQFNHSVFPVPEMQNVTFCDRIDTSPLDELGNALKNVARWGLVALLLIAIVVMLIGVAWEWWKWQKEVKAVERTRSLWLAQRSSAHSDGNDKFCDNILKTENLMSLLTISQHPLISFCSLNYCKRLGIRTRRAQDRCAWLLSFLMHPASLACLFTGVLGLISVLMQAILVHSLSHHYVSSIDTSLAHLSSDIVNLVHDHTRNASVAFSTSANTVILQVEAELNDHVFRWVDTTTSTMNSTLNQFVDGLTETLTSTFGGTPFNAPLQTFVQCILGQKVQGIEKALTWIHENAYVNFSVVPADVLMLRPEQQEAVLRPVREAMLGSRDDQGGGNGVVGHVISRYMEHLHQEKILFTALIGVYAIILLIGLLAVLYATLAERRMHDDDETRKKVSRDESEEKLRSDLQAGPGGAGIARLWSRRPKLNAGCFRAFSHPPVPVSAQNPSSKIDHAARFPSSAHSSRPDPIHVTKDSISYPFQMHHSLNTSPSTRPTQPTPLQQTSNPDRDTVQSLHHASTTHNQTASTRTKEYDSWLCFLASYHDGEATVPAKAPEAVEGAQDRFHRLFGCSLRASPTVATFNHHVSAPAVSSDRAEIEVEDARFRETLDLGSMQDWIGSKSPIPPPAGRGGSHSPRNTADQLPEVQLTRSGGCVGPHSSDSTQETYAFTDSVRLPPGPQPQQKRVVSSQSISFFAW", "function": "Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.", "AFDB_id": "AF-Q4P996-F1-model_v4" }, { "swissprot_id": "O06380", "sequence": "MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSAAPPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSRRSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGAVDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGPAGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT", "function": "Carboxypeptidase that cleaves terminal D-alanine from peptidoglycan in the mycobacterial cell wall. May cleave L-Lys-D-Ala and/or D-Ala-D-Ala peptide bonds. Exerts important effects on mycobacterial cell morphology and cell division.", "AFDB_id": "AF-O06380-F1-model_v4" }, { "swissprot_id": "A8L5A4", "sequence": "MGEPVVVGRVGRPHGIRGDVTVDVRTDLPERRFAPGARLVRQVADGPASRPAADAAGAADAVGTAAGPGSAGDSGAARAAGPPVATVLSVVASRWHSGRLLVRFDGVTDRDAAEALRGSFLTIDSDECGPAVDPDDEDDDGELWWDRDLVGLHARTPAGDVLGEVVDVIHSPGGEILAIGRPEGGEYLVPFVREIVPTVDPAAGHIVVDPPPGLLDLD", "function": "An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.", "AFDB_id": "AF-A8L5A4-F1-model_v4" }, { "swissprot_id": "P14789", "sequence": "MQHKRSRAMASPRSPFLFVLLALAVGGTANAHDDGLPAFRYSAELLGQLQLPSVALPLNDDLFLYGRDAEAFDLEAYLALNAPALRDKSEYLEHWSGYYSINPKVLLTLMVMQSGPLGAPDERALAAPLGRLSAKRGFDAQVRDVLQQLSRRYYGFEEYQLRQAAARKAVGEDGLNAASAALLGLLREGAKVSAVQGGNPLGAYAQTFQRLFGTPAAELLQPSNRVARQLQAKAALAPPSNLMQLPWRQGYSWQPNGAHSNTGSGYPYSSFDASYDWPRWGSATYSVVAAHAGTVRVLSRCQVRVTHPSGWATNYYHMDQIQVSNGQQVSADTKLGVYAGNINTALCEGGSSTGPHLHFSLLYNGAFVSLQGASFGPYRINVGTSNYDNDCRRYYFYNQSAGTTHCAFRPLYNPGLAL", "function": "Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate.", "AFDB_id": "AF-P14789-F1-model_v4" }, { "swissprot_id": "P55473", "sequence": "MEVGRYLKEGLLISLQQRLREFAEGIRKPTSSLKVHRQIVSLLEKPDPVILDIGCNDGSDARRFLQLRPKAQLFCFEPDPRAAARCRENMGPLDRMRLFEVAISDRNGRIDFHPSNGDGDAKEWDLSGSIRQPKNHLSEYQWVRFDGPISVETRRLDDWCSEAGLESIDLIWMDVQGAESDVIAGGKETLTKTRFIYTEYSDQELYEGQLPLRAILDLLPSFELVAQFPRGVEGDVLLRNTKL", "function": "Required for 2-O-methylation of the fucosyl group of Nod factors.", "AFDB_id": "AF-P55473-F1-model_v4" }, { "swissprot_id": "Q8SX86", "sequence": "MSDTKSEIEGFIAIPTTSGEQQQQQPQQQQNEQQVVGTKDIKAPDQVGKKQRPRLIQEKSTQETNPLILEHATLEWVPQHMDKLLNQYQECRKMPAAEWLHLLTYLVALECGFVEEETFAQKRHLIQPVPSFSSFHAQNVRILSEQPARYEVCFNDTVYIMRLRTLLDKHAPEETSLVAALQCRLMAVSLGDQLMITLSPAPPSKEPGYSVSLSIGRYVLNIQAKNKPIYHRFRKLDELSYQLKQHLFQPMRSQQLMQMEMKLQPSLLGLPDELYFEIFRYLDKSQLNVVARVNRHLHFYSKEVERKRLKGGRS", "function": "Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability.", "AFDB_id": "AF-Q8SX86-F1-model_v4" }, { "swissprot_id": "A0A1W2PS18", "sequence": "MALKPPSATQPAPNAPATPDAPPTTGDPGASAAPGSPTTTGGPGAPAEVPQEPQEPTQTPEELAFYAPNYLCLTIFAILLFPPFGLAALYFSYEGSWTQKPTSMLPPLQTMKANQNSEWEEAYINSGRTGWFGAFVVMIGLGIIYGLVLY", "function": "May play a role in spermatozoa mobility.", "AFDB_id": "AF-A0A1W2PS18-F1-model_v4" }, { "swissprot_id": "C9X1G6", "sequence": "MTWRSLLIQNGGKLSLQRRQLLIQQNGESHTVPLEDIAVIIIENRETLITAPLLSALAEHGATLLTCDEQFLPCGQWLPYAQYHRQLKILKLQLNISEPLKKQLWQHIVRQKILNQAFVADETGNDLAAKRLRTLASEVRSGDTGNREAQAAALYFQALFGEKFTRNDNNAVNAALNYTYAVLRAAVARTLTLYGWLPALGLFHRSELNPFNLADDFIEPLRPLADLTVIHLYEQGRLKAELTPGIKQHLIKTLHYQISIERQHFSTLAAIDKMVSSFQAGVTDKNAKQLKLPEILPLKEYQYE", "function": "CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.", "AFDB_id": "AF-C9X1G6-F1-model_v4" }, { "swissprot_id": "Q12385", "sequence": "MWTNTFKWCSKTEKETTTADAKVCASVQGLKALQQQIMDSTTVRGSVNNTMTPGGINQWHFHNKRANKVCTPTVLIHGYAASSMAFYRTFENLSDNIKDLYAIDLPANGASEAPALQVNKTKKIKSLRFKHIEDDVVIPVIEKRPPAEDIKSHLEQYESYFVDRIEQWRKDNKLRKINVVGHSFGGYISFKYALKYPDSIEKLCLISPLGVENSIHAITHKWEPNTTYPLTFTDPSSRYYTRKLNVPRFIFENQLNVLKWMGPIGSKLCSNYISTAYVKVPDQIYKDYLLHSFVGKNQTVQPQTIKVFTHLFERNLIARDPIINNVRFLNPATPVMFMYGEHDWMDKYAGYLTTESMLKNKAKASYVEVPDAGHNLFLDNPQHFASSLVSFLSK", "function": "Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper.", "AFDB_id": "AF-Q12385-F1-model_v4" }, { "swissprot_id": "P26408", "sequence": "MAASAPAILLVDDEPHSLAAMKLALEDDFDVLTAQGAEAAIAILEEEWVQVIICDQRMPGRTGVDFLTEVRERWPETVRIIITGYTDSASMMAAINDAGIHQFLTKPWHPEQLLSSARNAARMFTLARENERLSLEMRLLNSTSESRVEKRRRALREGMGFETILRTPNSAMTGAIALARQFASFDVPVLLRGEPGSGRAQLARAMHYVSLRSDKPFYEINLAGLPEDLAMIELFGARRGVLPGGVAKIGLAQKADRGTLFVAGVEAASPALQLALLRMLADGAITPLGGQETASTNLRLITGAAADLRAMVAEGRFRADLYYALSAGEIALPPLRARRGDVALLAQSMLAEAAVRHGKQALGFDAAALEFLENYDWPGNLRELHNEVTRMLIFAQDNVLGAELISRHILQAAPSESGADRSAEEVMTADGTLKDRIELIEMRILRETLTRNRWNKSRAAAELGLSRVGLRAKLDRYGIEHPAGRVQEEEED", "function": "Probable member of the two-component regulatory system involved in the regulation of the [NiFe] hydrogenase activity. HupR1 is probably phosphorylated by the sensory component and then acts in conjunction with sigma-54 as a transcriptional activator.", "AFDB_id": "AF-P26408-F1-model_v4" }, { "swissprot_id": "A0RW14", "sequence": "MSEMQFGKHLDELRRRALRVVVITGAVTAFLLAFHAEPAELWGATVYYPVPDPLHNMAAQITDHMRAALVPEGVELIQTTPGQAFFAQVYIAALVGVTVSTPVAVRELAAFLRPALRESEIHVGRSISAPAVGLFAAGCAFSYIVVIPYILDFLYKIGESAGITTFLNVMDFVSFVLQFLLAFGISFQLPLVMFAVTASGMVDGRFWRRNIRYALLGIVIFGAAITPDGSGVTMWFVAGPMIGLYFAGMFFAERRERKEKSAGA", "function": "Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.", "AFDB_id": "AF-A0RW14-F1-model_v4" }, { "swissprot_id": "Q6FKA3", "sequence": "MKSTQQLGQEAREFEFNPNIPLHLYLKTCVTLLNNASECFQRGDKSLSYFYYFRYVDLCTNKLPNHPTIRSTSTGLDNDSKLYVQEYKQLLRLEVPHILKIMEELKTELDAMYERHKVSLANNIASPISYKHNNRMDALLHDYYTERGCTGHSMQHKTSLHKNENFNERINLMKDSFMGRAPNGSQEVRNVSNTFYPDLPTLS", "function": "Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.", "AFDB_id": "AF-Q6FKA3-F1-model_v4" }, { "swissprot_id": "Q08DU9", "sequence": "MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDNTMPIRRAVNSTRETPPKSKLAEGVEEKPEPDVSSEESISTVEEQENETPPATSSETEQPKGQPENEEKEENKPSEETKKDEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKPPQKSRNRKNRSSAVDPEPQVKLEDILPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQRCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSKDEDEDEDEDDSSEEDSEDEEPPPKRRLQKKTPVKSPGKAAAMKQRGSKLAPKVPAAQRGKTRPLPKKAPPKAKSPAKKARPSPSVIKKPSGSSSKKPAASVRKEVKLPGKGKSTMKKSFKAKK", "function": "Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis.", "AFDB_id": "AF-Q08DU9-F1-model_v4" }, { "swissprot_id": "Q87J97", "sequence": "MHGFRALKSEVIMSNMTNAAPHTPIQEADYSAIHPPSLLKRLELTNPVFWLSGSFLSLFVLLALTNTESLTAMVNAGFGFATKYFGAYWQVLLLLNFLIGLALAFGRTGYVRLGGLAKPDIDTFKWLSIVLCTLLAGGGVFWAAAEPIAHFVTAPPLYGEASPKTSAINALSQSFMHWGFLAWAILGCLSSIVLMHLHYDKGLPLKPRTLLYPIFGDKAIHGWIGNLADACSIIAVAAGTIGPIGFLGLQISYALNSLFGFPDNFITQSMVIVAAIVMYTLSALSGVSKGIQLVSRYNIILSVLLIGYILFFGPTSFIIDGYVQGVGRMVDNFFPMALYRDDTGWLSWWTVFFWGWFIGYGPMMAIFIARISRGRTIRQLILSISIAAPLITCFWFSIVGGSGLAFELANPGLISSAFEGFNLPAVLLAITGELPFPMIISVLFLILTTTFIVTTGDSMTYTISVVMTGSAEPNAVIRSFWGLMMGVVAIALISMGSGGITALQSFIVITAVPVSFILLPSILKAPGIANQMAKDQGLV", "function": "Involved in the uptake of the osmoprotectant glycine betaine.", "AFDB_id": "AF-Q87J97-F1-model_v4" }, { "swissprot_id": "Q15UB6", "sequence": "MLLPNTNWFWYTHENELRLDLGDTLTFVAPFALKNLVNLPSDKQLFSLEDTEHYVALAESLDNSGLELSDGELVQILLNATAALKFHKPIGMKSWLYKTQSTSGVHYQLALLEPTDTAYPELGQVIVIEQDGACATCMLISNEFAVNSSKKFSKFEMIKVMNDRLIPCLVDIPVYKRA", "function": "Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.", "AFDB_id": "AF-Q15UB6-F1-model_v4" }, { "swissprot_id": "Q07984", "sequence": "MAAMASFGALALLLLSGLSCCSAEACLEPQITPSYYTTSDAVISTETVFIVEISLTCKNRVQNMALYADVSGKQFPVTRGQDVGRYQVSWSLEHKSAHAGTYEVRFFDEESYSLLRKAQRNNEDVSIIPPLFTVSVDHRGTWNGPWVSTEVLAAAIGIVIYYLAFSAKSHIQA", "function": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.", "AFDB_id": "AF-Q07984-F1-model_v4" }, { "swissprot_id": "O42941", "sequence": "MATLTNLEPLATGTVILKTTRGDIQIELWCKEVPKACRNFIQLCLEGYYDGTIVHRVVPEFLIQGGDPTGTGMGGESIYGEPFAVETHPRLRFIRRGLVGMACTENEGNNSQFFITLGPTPEWNGKQTLFGRVVGDTIYNVVRISELELDANQRPVFPPKIISTEVIDNYFTDIKPRSTKEEREKIANELAHQEKQKERNKLLKSGRRNKAVLSFGDEVDMPIVKKPLRQKTPVSRSSDTTTELSKDLISSSSSIHSTYSSAQTGLTSAKVSSDEYARQVDTLDTKLNSSSKSKVQEEISRLKSELRDLEKSGGSSNSKPVVVRPKKRNILTEELEKYKKSKKVVLGKRKNLENDEESTLRALSSFQSKIRNAEDEDVMDSQYGSKIEDTPCSLHNVPGCFSCFDRLGEKNITETNSNWFAHRLVAENDPTRRTEELRIQRAEELKDVPSARPKKLLMKRDII", "function": "PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.", "AFDB_id": "AF-O42941-F1-model_v4" }, { "swissprot_id": "P45320", "sequence": "MTTNNKQRQTWSSRLTYVMTVAGATVGFGATWRFPYLVGENGGGAYVLLFCIAMIVIGIPMILVENVIGRRLRVNSIDAFGDKILDKGKGISKYWKILGYMGLLGAFGIMAYYMVLGGWVISYIISLISGTLDISTPITKDIAKNFYDLHIGNSPYEIIFYTLLFVIVNYIILAKGIIGGIERSVKYLMPLLFIFLIGMVIRNVTLPGAMEGITFYLKPDFSKITPQLFIFVLGQVFFALSLGFGVLITLSSYLNKEENLIHTAVITGFTNTIIAVLAGFMIFPSLFTFGIEPNAGPTLVFQSLPIVFSHLWAGKFFAIIFFGLLLIAALTTSITIYEVIITALQEKLRMCRGKAIVLTLSGIFLLGNIPAILGDNLWKNVTIFGKSIFDFYDYASGNILFMLTALGCAIFVGFVLKDEAKKELSSTKYSTFIKIWFNYVKFVVPLIILVIFISNLF", "function": "Putative sodium-dependent transporter.", "AFDB_id": "AF-P45320-F1-model_v4" }, { "swissprot_id": "Q9KMA5", "sequence": "MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVPNGQAVTLLKLVQRHPETLSHIAEL", "function": "Antitoxin component of a type II toxin-antitoxin (TA) system that counteracts the effect of the HigB-2 toxin. Binds to its own promoter and regulates transcription of the higB-2/higA-2 operon.", "AFDB_id": "AF-Q9KMA5-F1-model_v4" }, { "swissprot_id": "Q9C7S6", "sequence": "MKNPSVISFLIILLFAATICTHGNEPVKDTAGNPLNTREQYFIQPVKTESKNGGGLVPAAITVLPFCPLGITQTLLPYQPGLPVSFVLALGVGSTVMTSSAVNIEFKSNIWPFCKEFSKFWEVDDSSSAPKEPSILIGGKMGDRNSSFKIEKAGEGARANVYKLTTFYGTVGAIPGVWLSAPQLIITKDTAKTLLVKFKKVDDATTATSNLYFPG", "function": "Water-soluble and chlorophyll-binding protein that probably does not function as a chloroplast chlorophyll carrier and is not involved in photosynthesis. Involved in the control of cell death in the transmitting tract and septum epidermis during flower development. Binds and inhibits the activity of the cysteine protease RD21A as a pro-death protein. May play a role in herbivore resistance activation during seedling greening.", "AFDB_id": "AF-Q9C7S6-F1-model_v4" }, { "swissprot_id": "Q94A41", "sequence": "MSTVPIESLLHHSYLRHNSKVNRGNRSFIPISLNLRSHFTSNKLLHSIGKSVGVSSMNKSPVAIRATSSDTAVVETAQSDDVIFKEIFPVQRIEKAEGKIYVRLKEVKEKNWELSVGCSIPGKWILHWGVSYVGDTGSEWDQPPEDMRPPGSIAIKDYAIETPLKKLSEGDSFFEVAINLNLESSVAALNFVLKDEETGAWYQHKGRDFKVPLVDDVPDNGNLIGAKKGFGALGQLSNIPLKQDKSSAETDSIEERKGLQEFYEEMPISKRVADDNSVSVTARKCPETSKNIVSIETDLPGDVTVHWGVCKNGTKKWEIPSEPYPEETSLFKNKALRTRLQRKDDGNGSFGLFSLDGKLEGLCFVLKLNENTWLNYRGEDFYVPFLTSSSSPVETEAAQVSKPKRKTDKEVSASGFTKEIITEIRNLAIDISSHKNQKTNVKEVQENILQEIEKLAAEAYSIFRSTTPAFSEEGVLEAEADKPDIKISSGTGSGFEILCQGFNWESNKSGRWYLELQEKADELASLGFTVLWLPPPTESVSPEGYMPKDLYNLNSRYGTIDELKDTVKKFHKVGIKVLGDAVLNHRCAHFKNQNGVWNLFGGRLNWDDRAVVADDPHFQGRGNKSSGDNFHAAPNIDHSQDFVRKDIKEWLCWMMEEVGYDGWRLDFVRGFWGGYVKDYMDASKPYFAVGEYWDSLSYTYGEMDYNQDAHRQRIVDWINATSGAAGAFDVTTKGILHTALQKCEYWRLSDPKGKPPGVVGWWPSRAVTFIENHDTGSTQGHWRFPEGKEMQGYAYILTHPGTPAVFFDHIFSDYHSEIAALLSLRNRQKLHCRSEVNIDKSERDVYAAIIDEKVAMKIGPGHYEPPNGSQNWSVAVEGRDYKVWETS", "function": "Possesses endoamylolytic activity in vitro, but seems not required for breakdown of transitory starch in leaves. May be involved in the determination of the final structure of glucans by shortening long linear phospho-oligosaccharides in the chloroplast stroma. Can act on both soluble and insoluble glucan substrates to release small linear and branched malto-oligosaccharides. Works synergistically with beta-amylase toward efficient starch degradation. Has activity against p-nitrophenyl maltoheptaoside (BPNP-G7), amylopectin and beta-limit dextrin. Involved in stress-induced starch degradation.", "AFDB_id": "AF-Q94A41-F1-model_v4" }, { "swissprot_id": "Q9D7J4", "sequence": "MAAAPEPHETEKKPFKLLGILDVENTPCARESILYGSLGSIVTGLGHFLVTSRIRRSCDVGVGGFILVTLGCWFHCRYNFAKQRIQERIAREGIKNKILYESTHLDPERKMKTNNSS", "function": "Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme.", "AFDB_id": "AF-Q9D7J4-F1-model_v4" }, { "swissprot_id": "P22152", "sequence": "MDFAKLLVASPEVNPNNRKALTIPVLNPFNTYGRVFFFSWFGFMLAFLSWYAFPPLLTVTIRDDLDMSQTQIANSNIIALLATLLVRLICGPLCDRFGPRLVFIGLLLVGSIPTAMAGLVTSPQGLIALRFFIGILGGTFVPCQVWCTGFFDKSIVGTANSLAAGLGNAGGGITYFVMPAIFDSLIRDQGLPAHKAWRVAYIVPFILIVAAALGMLFTCDDTPTGKWSERHIWMKEDTQTASKGNIVDLSSGAQSSRPSGPPSIIAYAIPDVEKKGTETPLEPQSQAIGQFDAFRANAVASPSRKEAFNVIFSLATMAVAVPYACSFGSELAINSILGDYYDKNFPYMGQTQTGKWAAMFGFLNIVCRPAGGFLADFLYRKTNTPWAKKLLLSFLGVVMGAFMIAMGFSDPKSEATMFGLTAGLAFFLESCNGAIFSLVPHVHPYANGIVSGMVGGFGNLGGIIFAIIFRYSHHDYARGIWILGVISMAVFISVSWVRPVPKSQMRE", "function": "Permease for nitrate uptake.", "AFDB_id": "AF-P22152-F1-model_v4" }, { "swissprot_id": "Q24266", "sequence": "MIDAACNYLNPYAQQHQAQQQQHAQHQQHAQQQQHHLHMQQAQHHLHLSHQQAQQQHMQHLTQQQQQQQQQQQQQQQQQQQQQQPQQQQHDFLSAAALLSAPPSLSGSSSGSSSGSSPLYGKPPMKLELPYPQASSTGTASPNSSIQSAPSSASVSPSIFPSPAQSFASISASPSTPTTTLAPPTTAAAGALAGSPTSSSPSSSAASAAAAAAAAAAAAADLGAAAVASAAYGWNTAYSGLGPARSQFPYAQYASDYYGNAVGMSSSAAWFSHQERLYQPWSSQSYPGFNFDDIAFQTQLQRRSVRCTCPNCTNEMSGLPPIVGPDERGRKQHICHIPGCERLYGKASHLKTHLRWHTGERPFLCLTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKKTHFKDKKSKKVLAAEAKEQAAAAIKLEKKEKKSGKPLTPPVEFKQEQPDTTPLVNYAPYANLYQHSTSAGSSVNPPPPPPPLFQQQMTTTTSSAAASFVEQPWSSSSSRAIQPATTSASSSSSSSASSPAAAVVSAIGSASSPAASATALAQHHYAALAMQSESQLAAEYGLTMSGLASGASQDSSSSCHMKSEYAASYPADFGAGTASYGYPHPHPHHHNAWAAAYHPHATA", "function": "Required for the development of the antennal, intercalary and mandibular segments of the head.", "AFDB_id": "AF-Q24266-F1-model_v4" }, { "swissprot_id": "Q890M5", "sequence": "MRKYFLGEEFTKQDLKQMNPLVLAYIGDAVYEIFIRTYIISKNKDTCVNKLHKKTIQFVKADAQSYFIREIQKYLNEEEIKVFKRGRNTKSNTSAKNASIQDYRMATGFETVIGYLYLLNEDERLEEIMKLVINLYEESSQNEGENHGSKS", "function": "Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.", "AFDB_id": "AF-Q890M5-F1-model_v4" }, { "swissprot_id": "P46957", "sequence": "MDALLTKFNEDRSLQDENLSQPRTRVRIVDDNLYNKSNPFQLCYKKRDYGSQYYHIYQYRLKTFRERVLKECDKRWDAGFTLNGQLVLKKDKVLDIQGNQPCWCVGSIYCEMKYKPNVLDEVINDTYGAPDLTKSYTDKEGGSDEIMLEDESGRVLLVGDFIRSTPFITGVVVGILGMEAEAGTFQVLDICYPTPLPQNPFPAPIATCPTRGKIALVSGLNLNNTSPDRLLRLEILREFLMGRINNKIDDISLIGRLLICGNSVDFDIKSVNKDELMISLTEFSKFLHNILPSISVDIMPGTNDPSDKSLPQQPFHKSLFDKSLESYFNGSNKEILNLVTNPYEFSYNGVDVLAVSGKNINDICKYVIPSNDNGESENKVEEGESNDFKDDIEHRLDLMECTMKWQNIAPTAPDTLWCYPYTDKDPFVLDKWPHVYIVANQPYFGTRVVEIGGKNIKIISVPEFSSTGMIILLDLETLEAETVKIDI", "function": "DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.", "AFDB_id": "AF-P46957-F1-model_v4" }, { "swissprot_id": "P52550", "sequence": "MAKRPRTSEEDDDFQYADHDYEISQQRSLKKICNRVKWTRDEDEKLKKLVEQNGTDDWAFIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEAEDRVIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGTKSSSERTGSSTLAQKPCVTMEHLHTQNQFYIPVQTHIPVYQYASPEDSCIEHASASANLVQQSFIDDDPDKEKKIKELELLLMSTENEIRRKRLSSQAGSLPGWSGSFVMEDCVPNTLNSLGEQTSEFYSMDETQGTSVQQNSPTKYLAVEANAVLSSLQTIPEFAETLELIESDPLAWSDVTSFDLSEAVASPVKPAPLKLMRIQHNERAAECQFNVSVMLDGKKHSSISGEEEAVFPTTPNLTKYSTPPAILRKKKRLRAGQSPVNELNDGLCNDAINVALKHTPVKTLPFSPSQFFNTCSGNEQFNLENPAFTSTPICGQKVLITTPLHKETTPTDQKENAGFRTPTIRRSLLGSTPRTPTPFKNALAAQEKKYGPLKLTSQPLAFLEEDIREVLKEETGTDIFLKEEDDSVYKSCKQEHNSSKKVRKSLVLDAWEKEELGAQLFTEDSGLDVQSENAYTTSLLMIPLLEIHDNRCNLPSENQDTNSSNKANAVIKKKLNACSSKNIKLEKSLQPNYEWEAVVYGKTEDQLIMTEQARRYLNAYTATSNTSRALIL", "function": "Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.", "AFDB_id": "AF-P52550-F1-model_v4" }, { "swissprot_id": "Q03660", "sequence": "MDKEIYCGSVPVSYFDPFDLFESLRPEFQQILPLDNIHWKAFDGTVRTVNRLPIELIPEGRGEADKSNDEQPFIRFLIVNCISIDQYRAKVRPLVRQWLPNLESVSSSTGEKMIYKPIILLYANSEVVDSNLFKSVSLMEKFGKDFPHVQTLEVRSVYRSPKERQEFWNQFSQKIKASVLSIFQKRLTHLQHSLANLQKGNNFEEQLLTREKLYELYVVFNILEDASLELQKIKKEILRRNMNMPDGKLQVPFESSSKSDESLGSIIIEGTLDKFQLHKYFFIRRLRLLKLEDQTLTAFVGAFQLIKNFIESISIEYRKSVRLLEFKHYFITSMLSYFEFENVSNPLLCEIKAELLMLKRDNWVQGVMATSGYRLMDKNYPNSDVKYKFDLLKETFVDETVFQENFLTLTKEILSLFNKCEGKRQRIVDILSIEIGLLYYQGKKYEEAVSLFLSCYEYYTQTNWNSIGLKILQVFIDSLSHCPKLDVLQIDGESVSASAVLTNAFLNILKLCKDNDSKEIWWKKFMDLQMKNNIHLMYPLDGLFEVTLNSKVHLARANVSAIEVNLKSYGFPEDISTKTMRLSLKNMGGDVIVFGASDFLLKKGENKLILECRDIMYGEFSLLSFEIIVEGITFVKEFPENQDEFIVVPEIYCKESTKVLVKQAHNLNLGEYALELKSVQSDALESLQVEVEVQKNIGNMKNLPVSFSMDEIQARKRYNTPFENVRLEYYLLDQITAFDLIIKTSFTKKNDQGTFGETKKVRIQCYLQLSVSVEDIFKKDIFFFKFLLNSSVREEPVILYSSELSAPDTRNDYNIRGDYIATTPALITFDGNESFINCYEITANNNFDSKDIFNLKVRYNTLKEQLDCFITDAVLIEGDVEWFILFEKWKTFWELEILKKLKYDYDAFKENRIIRLLKTSIDLNKTKSKIRNLCIEKAVLDKILICLNKVSRGIAVCNTDMDEYVRNLVPKQLTVPVQLPGFEQFFHVQFEQMETSHDALHDTIATIGNSLSYTVIVENLSGQWGQDVIDDGGYIFEILSSNEWLIHGQKRCAIKEKRKEFEVHLIPLKKGYLNFPRVEITNINGKSCRVDHSNAFESILIF", "function": "Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchange factor (GEF) for the Golgi YPT1 GTPase. TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120. Required for both the cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy through its role in ATG8 and ATG9 trafficking.", "AFDB_id": "AF-Q03660-F1-model_v4" }, { "swissprot_id": "P27611", "sequence": "MEKKATVGFTLLLLGVMMAIIITSMFVLKVEPHIPLVVCLLIAAVFGRYLRVGWNDLESAMIDGLKIGIKPIFILALVGIVIAVWMMSGTVPTLLFYGLSIISPEWFAVSTLLICMIVSSFTGSSFTTVGTIGVAMMGIGTALGIDPAIAAGAVVCGACFGDKMSPLSDTTNFAPGIVGVDLFDHIRHLLWTTVPSFVITVILFLMIGRSQATSTTQDIQAMLTALDSQFTLSVLTLLSPLLVVILAMRRFPTIPVLVVGILTGIITAAFVQGNADVARWFTIIQNGFSMETGNEVIDGIVNRGGLQSMMWSISLVMIALTLGGVIQRIGVIDTLLQSLTRKLSSRGHLIAATATSSIGVNVVTGEQYLSILLPGKTFESFYTKLNVAKKNLSRTLEDAGTLVNPLIPWGVSGAFFASTLGVDVIDYLPFAFFLFLSPFMTILFGYLGIGVGKEQSLANKRG", "function": "Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion.", "AFDB_id": "AF-P27611-F1-model_v4" }, { "swissprot_id": "Q9CPD1", "sequence": "MTTFIAYGNINDTYPLDSIPRELLIEKLRQPQSSNQRVQKRHRCRWVAHFLLWQLLKISQKPTALLKHIDYSQSGRPQLPVHDVDFNISHSGDWVAVILRVNTQGDSIVGIDIESPQKERDYPALLAYFASPSEQAWFTQQQEKEKSFYLSWCLREAVLKSQGVGIVKLSAVQHDPLLRQIQSQHCPAGQLVFSHRLPFYLAFFINQTQCLDVHYFTWQRGILAETTLHDAIYYKVNEKT", "function": "May transfer the 4'-phosphopantetheine moiety from coenzyme A (CoA) to a serine residue of a carrier protein domain.", "AFDB_id": "AF-Q9CPD1-F1-model_v4" }, { "swissprot_id": "Q5SJ47", "sequence": "MRDRVRWRVLSLPPLAQWREVMAALEVGPEAALAYWHRGFRRKEDLDPPLALLPLKGLREAAALLEEALRQGKRIRVHGDYDADGLTGTAILVRGLAALGADVHPFIPHRLEEGYGVLMERVPEHLEASDLFLTVDCGITNHAELRELLENGVEVIVTDHHTPGKTPPPGLVVHPALTPDLKEKPTGAGVAFLLLWALHERLGLPPPLEYADLAAVGTIADVAPLWGWNRALVKEGLARIPASSWVGLRLLAEAVGYTGKAVEVAFRIAPRINAASRLGEAEKALRLLLTDDAAEAQALVGELHRLNARRQTLEEAMLRKLLPQADPEAKAIVLLDPEGHPGVMGIVASRILEATLRPVFLVAQGKGTVRSLAPISAVEALRSAEDLLLRYGGHKEAAGFAMDEALFPAFKARVEAYAARFPDPVREVALLDLLPEPGLLPQVFRELALLEPYGEGNPEPLFLLFGAPEEARRLGEGRHLAFRLKGVRVLAWKQGDLALPPEVEVAGLLSENAWNGHLAYEVQAVDLRKPEALEGGIAPFAYPLPLLEALARARLGEGVYVPEDNPEGLDYAWKAGFRLLPPEEAGLWLGLPPRPVLGRRVEVALGREARARLSAPPVLHTPEARLKALVHRRLLFAYERRHPGLFSEALLAYWEVNRVQEPAGSP", "function": "Single-stranded-DNA-specific exonuclease acting in a 5' to 3' direction; has no detectable activity on ssRNA.", "AFDB_id": "AF-Q5SJ47-F1-model_v4" }, { "swissprot_id": "Q51574", "sequence": "MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNAGPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR", "function": "Hydrolyzes oxacillin, first-generation cephalosporins and ceftazidime. Does not hydrolyze cefotaxime or carbapenems.", "AFDB_id": "AF-Q51574-F1-model_v4" }, { "swissprot_id": "B5GS26", "sequence": "MSTRPVEGSAIWDVLSPHSPHAAAADGKTLVWVEAGELCGHDTAESANLARIRPGLLAAFCHPKATEDDLTLITKWMAWLFLLDDRIDESDLGRDADLLDGHLQDLQGVALGIRTASGPMSRALEEIITQASAGMGDAWQLRFRRNISDYLLACVWQAAHRQAGEFPDPEVFPHWRRAFGAIMPSFDLIERTDGGALPSCVYYSRPYQSLLTAAADLVCWTNDLMTVDKEAAHGDLHNLVLVTEHDRHQDRRTASAAVSAACEQRMRAHTSARRDLTGLTAALGLPDTVRTHADDCAASLLVWVRGHLEWGLETPRYRPGTTGTGTD", "function": "Catalyzes the conversion of (2E,6E)-farnesyl diphosphate into (-)-delta-cadinene. Cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation.", "AFDB_id": "AF-B5GS26-F1-model_v4" }, { "swissprot_id": "Q8YK97", "sequence": "MDLNTYLKLLNLLDSESQKIMLELQAMFSAAGLALRGRGTHTDGIIVKGNLTVLHSSDVPSHSLFTPGKKYDVIFRHANIVGGAKDDALINGRGSAIRIGNIGDDLSKPRLLDLVLNTGEVFGLPTARLYHQFFGSDFHQKSDMLASGSLRRYAVEAALRNPDSFTELYYHTQLCYEWVDSKKKSRYARFRLLNPNQSTEGGLLDDSVEIGPRLVLPRKRGDTREKNYLRNEFRQRLTDGNIVEYVLQAQFRSIEDVAVDCSNIWDPNTYPWLDIAAIVLNQDESENDYYQEIAYNPGNTHYDLKLPNSYSVDDFASLGVSGALVHYFGSIVRAERTQYLYGSKDDLPGKPVYFPLPVTEIPSKRFLFLLEKYNFLTDNSYPSDGEHDKIEALVSAMPTTALDLAVGTTDPTDIPDSYFLERRLNGYNPGAIRESSGQEGWTHELTHNLAKYDIKPGLHFPDFVQCRLFVDKQNGVKLHSIKIDDHEITPCQEQWQYAKRTYLQAEFLSQELKLHLARCHFNIEQYVMAIKRRLAPTHPVRAFINPHLEGLIFINSSAVPKIIGSTGFIPIASMLTQGSIVDVMKNELSKLSYMWNPIADLPRDIPGDLFTPAATAYWELLNNYVEQGLLQPFEDELRTEVNAIQVDELFAELKERSLYSGDQPPKYDSSELKSLLMYIIYHSSFLHSWANFKQYDDAGNPNHVSMGDYSQYDQQTQDKIRFSQRSLTWVLSSIRYNSVAVYGSDLLKQLIREKSSILEPGLPLEDLMMSINI", "function": "Catalyzes the conversion of alpha-linoleate to (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate in oxylipin biosynthesis. Also converts alpha-linoleate to (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate.", "AFDB_id": "AF-Q8YK97-F1-model_v4" }, { "swissprot_id": "P19841", "sequence": "MCNAEFKGDCMIKKIPMIIGGAERDTSEHEYRELTLNSYKVSIPIINQDDVEAIKSQSVENNLNINQIVNFLYTVGQKWKSENYSRRLTYIRDLVRFLGYSPEMAKLEANWISMILSSKSALYDIVETELGSRHIVDEWLPQGDCYVKAMPKGKSVHLLAGNVPLSGVTSIIRAILTKNECIIKTSSADPFTAIALASSFIDTDEHHPISRSMSVMYWSHNEDIAIPQQIMNCADVVVSWGGYDAIKWATEHTPVNVDILKFGPKKSIAIVDNPVDITASAIGVAHDICFYDQQACFSTQDIYYIGDNIDAFFDELVEQLNLYMDILPKGDQTFDEKASFSLIEKECQFAKYKVEKGDNQSWLLVKSPLGSFGNQPLARSAYIHHVSDISEITPYIENRITQTVTVTPWESSFKYRDVLASHGAERIVESGMNNIFRVGGAHDGMRPLQRLVKYISHERPYTYSTKDVAVKIEQTRYLEEDKFLVFVP", "function": "LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.", "AFDB_id": "AF-P19841-F1-model_v4" }, { "swissprot_id": "Q9JLV6", "sequence": "MSQLGSRGRLWLQSPTGGPPPIFLPSDGQALVLGRGPLTQVTDRKCSRNQVELIADPESRTVAVKQLGVNPSTVGVHELKPGLSGSLSLGDVLYLVNGLYPLTLRWEELSTSGSQPDAPPDTPGDPEEGEDTEPQKKRVRKSSLGWESLKKLLVFTASGVKPQGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKLGVPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGRLANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFLEILEIPFRLQEHLDPALQRLYRQFSEG", "function": "Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.", "AFDB_id": "AF-Q9JLV6-F1-model_v4" }, { "swissprot_id": "P27243", "sequence": "MLTSFKLHSLKPYTLKSSMILEIITYILCFFSMIIAFVDNTFSIKIYNITAIVCLLSLILRGRQENYNIKNLILPLSIFLIGLLDLIWYSAFKVDNSPFRATYHSYLNTAKIFIFGSFIVFLTLTSQLKSKKESVLYTLYSLSFLIAGYAMYINSIHENDRISFGVGTATGAAYSTMLIGIVSGVAILYTKKNHPFLFLLNSCAVLYVLALTQTRATLLLFPIICVAALIAYYNKSPKKFTSSIVLLIAILASIVIIFNKPIQNRYNEALNDLNSYTNANSVTSLGARLAMYEIGLNIFIKSPFSFRSAESRAESMNLLVAEHNRLRGALEFSNVHLHNEIIEAGSLKGLMGIFSTLFLYFSLFYIAYKKRALGLLILTLGIVGIGLSDVIIWARSIPIIIISAIVLLLVINNRNNTIN", "function": "Adds the O-antigen on the glucose group of LPS.", "AFDB_id": "AF-P27243-F1-model_v4" }, { "swissprot_id": "Q9Z5U2", "sequence": "MADKRFFGTKTFPNQEKALKAKIMNNDAFISWIEKNLGHRPKDPALFLRAMTHPSHGNSDYQRLEFLGDRVLGLVIANWLYDLFPREPEGKLSRRLNSLVSGASCASIARIVGLPQWLRLGKQARDDGAAASDNVLGDVMEAMIGAIFLESGIEAAGKLIHKYWAPLVTGQESAPKHPKSALQEWAAAHNRRPPVYEIVSRTGPQHNPCFTIQVSIAGVGEASAEGSSKQEAQTAAAQALLDILAQ", "function": "Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.", "AFDB_id": "AF-Q9Z5U2-F1-model_v4" }, { "swissprot_id": "L7P9J4", "sequence": "MNKSILLLVTLLSLYSCTDTEKTPLEEKDVFNEDYIKTSMIKALEWQEAHPIFAIHPTDWTNGAYYTGVARAHHTTKNMMYMAALKNQAVANNWQPYTRLYHADDVAISYSYLYVAENEKRRNFSDLEPTKKFLDTHLYEDNAWKAGTNRSKEDKTILWWWCDALFMAPPVINLYAKQSEQPEYLDEMHKYYMETYNRLYDKEEKLFARDSRFVWDGDDEDKKEPNGEKVFWSRGNGWVIGGLALLLEDMPEDYKHRDFYVNLYKEMASRILEIQPEDGLWRTSLLSPESYDHGEVSGSAFHTFALAWGINKGLIDKKYTPAVKKAWKAMANCQHDDGRVGWVQNIGAFPEPASKDSYQNFGTGAFLLAGSEILKMR", "function": "Glucuronyl hydrolase involved in ulvan degradation. Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall. It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl). Unsaturated 3S-rhamnoglycuronyl hydrolase works together with ulvan lyases to fully degrade the ulvan polymer, catalyzing specifically the cleavage of the unsaturated 4-deoxy-L-threo-hex-4-enopyranosiduronic acid (deltaUA) of deltaUA-Rha3S disaccharides and deltaUA-Rha3S-Xyl-Rha3S tetrasaccharides, the end products of the ulvan lyase reaction. Also hydrolases deltaUA-Rha3S-IduA-Rha3S and deltaUA-Rha3S-GlcA-Rha3S tetrasaccharidestetrasaccharides. Prefers tetrasaccharides over disaccharides and prefers an uronic residue at subsite +2.", "AFDB_id": "AF-L7P9J4-F1-model_v4" }, { "swissprot_id": "Q5GW40", "sequence": "MAGAARDRAFLDHFGGAGADRPCHVEGALMNDMSRQATRLDAIGGRYDPWLLGAAVTLASLGVVMVASSSIELEASPFYYLTRHLLFLGGGIALAFWAMRTELKTIEQHNQMLLLACFVLLVVVFVPGLGSTVNGAKRWINLGVSRFQVVESVKVFYIIWLASYLVRFRDEVNATWQAMLKPVFVVGLLVGLLLLQPDFGSSMLLLSVTACMLVLGGAPIGRIILPILLLLPALVALVIFEPYRMRRVTSFMDPWVDQLGSGYQLSNALMAIGRGQWTGVGLGASVQKLNYLPESHTDFIFSVIAEELGFVGVCGVIGLYALLVGRAFWLGMRCVEMKRHFSGYIAFGIGLWIAMQSFVSIGVNLGILPTKGLTLPLISSGGSSVLMTCLAMGVLLRVSYEADRAERLRSKLSPQGAAISPGEPAEPVVDAVPPAYAPARKPQRDTAAAPAPAAAPVAAHVAPASAILRGTSRMQPRVEPTFGRIA", "function": "Peptidoglycan polymerase that is essential for cell division.", "AFDB_id": "AF-Q5GW40-F1-model_v4" }, { "swissprot_id": "Q45271", "sequence": "MKFYRCSSPAPRFQAVTPGEKIRETSVLTSLVQPGAREKARQMVSGSSNDRFVVSRRRTGFGDCLWSLAAAWRFAKQTGRTLAIDWRGSCYLDEPFTNAFPVFFEPVEDIGGVRVICDDDINTRSFPGPFFPTWWNKPSFDCIYRPDEQIFRERDQLDQLFQSQRDSDANTVVCDACLMWRCDQEAEREIFRSIKPRPEIQARIDAIYREHFEPYSVIGIHVRHGNGEDIMGHAPYWADTERALRQIYNAIDEARSLSHAKPVRAFLCTDSALVLEQVSVKFPDVFAIPKQFQAPQAGPLHHPALGAEGGFSALTEMYLLARCDTVIRFPPTSAFTRYARLFAPRVIEFDLNDPGRLILIEDNSQALMAS", "function": "Fucosyltransferase which adds the fucose moiety of the nod factor on its terminal reducing N-acetylglucosamine end. Uses GDP-fucose as the donor group.", "AFDB_id": "AF-Q45271-F1-model_v4" }, { "swissprot_id": "B1VG72", "sequence": "MPDLQIGRVIKPHGVKGEVVVDPSTDHVPERFAIGEALRAVQTGKERQLTVTGMRRHQNRLLVTFEEIRDRDEAESLRGARFMAAPLHDDSDDGYYDHELIGLRVLNVGSVDADTANRRAYEGEQPEPVDIGEVTGVSHGPAGATLEVAVDADADLPTAGSTILIPFKLAIVPIVDLDNEALVVTPPEGLLELA", "function": "An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.", "AFDB_id": "AF-B1VG72-F1-model_v4" }, { "swissprot_id": "P47976", "sequence": "MMPNVAPNSYYLNIPNANSTSTTTSSIFSDLNKEYESKIKEIEEYYIKTLLNENTDNDDSSSSEGHNINETDILSEYSPRPSPWLPSKPNCYHPLGDFKDLIISDSRPTNTLPINNPFAGNNNISTLATTEKKRKKRSLEVEINPTYTTSAFSLPLTAENLQKLSQVDSQSTGLPYTLPIQKTTKLEPCRRAPLQLPQLVNKTLYKTELCESFTIKGYCKYGNKCQFAHGLNELKFKKKSNNYRTKPCINWSKLGYCPYGKRCCFKHGDDKDVEIYQNANDGRSKDTALTPLPTSLAPSNNDNITNLSKPRNLHTSVKALQRMTW", "function": "Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Negatively regulates primarily iron-dependent mitochondrial processes including respiration and amino acid biosynthesis.", "AFDB_id": "AF-P47976-F1-model_v4" }, { "swissprot_id": "P31532", "sequence": "MRLATVIVLCSLFLGVSGDGWYSFFREAVQGTWDLWRAYRDNLEANYQNADQYFYARGNYEAQQRGSGGIWAAKIISTSRKYFQGLLNRYYFGIRNHGLETLQATQKAEEWGRSGKNPNHFRPEGLPEKF", "function": "Major acute phase reactant.", "AFDB_id": "AF-P31532-F1-model_v4" }, { "swissprot_id": "O42957", "sequence": "MIGKRNASKRTRQDDCITYEEYQRKRKKTFLNTFVNICSRTVTYAKLFLTKTPISELDRIAGEAIPSNSNSTNSKLEPSTKAPESRFSHINSKTERGYVTVESDMSSHNTLDRNSKPTVSHSYTNSSKDEKFLDPIALQNLFSPASDTHSQNIHDEALSPSSFRVSRSRYFPRPHRSSKNLSVSNRLQLAVFKETTSSTLSHGNSVEADEINSFNPTPFSSSPLHFTNSSPNPNSDIVTPDKQLDVVSEHARYKHLPFTATLRKKSPHDSTSRKASFRFVQSDQQPARNIVTSDIQNEKSLLLLIRDLKEKQTESFQDWNEVDFLQLKGLEISPPPTRPKFIPELEFPDNARKRALKYLNQSNSVSSSEPIITKFNIPITLKDLHTLRNRQWLNDEVINFYMNLISERSKIDSSLPRVHGFNTFFYTSLQRRGYAGVRRWAKKARVNIADMDAVFIPVHLDVHWCMAVINKSKKRFEYWDSLAGSPGKVFDLLRDYYIAETKGAVDVSDWENFMDDNSPRQRNGHDCGVFACKTAECVSRNVPVQFSQNDMPELRIKMAASIIDAQIY", "function": "A cysteine protease that proteolytically removes the C-terminus of pmt3.", "AFDB_id": "AF-O42957-F1-model_v4" }, { "swissprot_id": "A5F7A4", "sequence": "MRFKNVKKTALMLAMFGMATSSNAALFDYNATGDTEFDSPAKQGWMQDNTNNGSGVLTNADGMPAWLVQGIGGRAQWTYSLSTNQHAQASSFGWRMTTEMKVLSGGMITNYYANGTQRVLPIISLDSSGNLVVEFEGQTGRTVLATGTAATEYHKFELVFLPGSNPSASFYFDGKLIRDNIQPTASKQNMIVWGNGSSNTDGVAAYRDIKFEIQGDVIFRGPDRIPSIVASSVTPGVVTAFAEKRVGGGDPGALSNTNDIITRTSRDGGITWDTELNLTEQINVSDEFDFSDPRPIYDPSSNTVLVSYARWPTDAAQNGDRIKPWMPNGIFYSVYDVASGNWQAPIDVTDQVKERSFQIAGWGGSELYRRNTSLNSQQDWQSNAKIRIVDGAANQIQVADGSRKYVVTLSIDESGGLVANLNGVSAPIILQSEHAKVHSFHDYELQYSALNHTTTLFVDGQQITTWAGEVSQENNIQFGNADAQIDGRLHVQKIVLTQQGHNLVEFDAFYLAQQTPEVEKDLEKLGWTKIKTGNTMSLYGNASVNPGPGHGITLTRQQNISGSQNGRLIYPAIVLDRFFLNVMSIYSDDGGSNWQTGSTLPIPFRWKSSSILETLEPSEADMVELQNGDLLLTARLDFNQIVNGVNYSPRQQFLSKDGGITWSLLEANNANVFSNISTGTVDASITRFEQSDGSHFLLFTNPQGNPAGTNGRQNLGLWFSFDEGVTWKGPIQLVNGASAYSDIYQLDSENAIVIVETDNSNMRILRMPITLLKQKLTLSQN", "function": "Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections. Facilitates cholera toxin binding to host intestinal epithelial cells by converting cell surface polysialogangliosides to GM1 monogangliosides.", "AFDB_id": "AF-A5F7A4-F1-model_v4" }, { "swissprot_id": "A5EWV0", "sequence": "MAEQKYRYTLHAVVREEQGKGASRRLRRQGLVPAIIYGGNTEPQAIAIKQDELKKNAKNHSFFSQIINLKIDGQEDQEILVRDVQHHIYKPLFQHFDFQRIVRGQEITATVLLEFVGEERAPGIKTDGGIVSRHMTTVEVICRPSLLPEYIAVDLSEANIGDIITLADLKLPEGVRLVGDMEDEEFAATVVVQISYPQREEQMEDTDTAAADEEGDKEEDADKQE", "function": "This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.", "AFDB_id": "AF-A5EWV0-F1-model_v4" }, { "swissprot_id": "Q7G4G7", "sequence": "MVVTFTSRRSEPVLLRPARPTPRETKQLSDLDDQRTLRYYETVVGFFRRCDGGAAGAVGAPADPAKAIRAALAEALVYYYPVAGRLREVADGGGAGNRLVVDCTAEGVVFVEADADVRLEDFGQPLLPPYPCVGELLCDAGDTRAVVGKPLLLMQVTQLKCGGFVLGFHICHNIADGFGMAQLIMAIADLARGEPAPTILPVWRRDLLTAARLGSGAVARTPFASAAAASASASSPALQNGARRAAAAADAMLSTPPDRMVVEYFLFGPREVSYLRGQLPAHLADSTTVFELLTAVMWRCRTAALGYGPDLRVRLMITMNARGRWNAHTPLPRGFYGNAHVSPVAEAAAGDLLGRPLADTVELVRRTKRGMTRERMSAMVETVAQLREWPPSSMDRVYEVSDIKWTTVNLLKFGWAEFAGGGIPLAGDLTSKLGSDHTRCKNSAGEVSTVVSMLLPRVAMARFKKEMAVLLNKDDKKSLTIMSSL", "function": "Involved in defense against pathogens. May contribute to disease resistance by potentiating disease resistance signaling, or producing phytoalexin-like secondary products.", "AFDB_id": "AF-Q7G4G7-F1-model_v4" }, { "swissprot_id": "C7MGB3", "sequence": "MITTTALVPARRSAVRTLLATVTEHDGVSPLDEAALLALDGEDARHLLLTADGAATDTHAAEATAGSAASADPADPADPAAPADPADPADETLLGYVSVLGDGTVQGMVDPAHRRRGHGSALLRAALALRPDAGVWVHGALEGSLAFLTDAGLTETRRLLTLRRDLGGAQPLPSAPAPTLEGLRLDTFEESRDAEAWVAVNVRAFADHPEQGALTRADLEQRLAQPWFDAEDMLVALRDETLVGFVWIKREQPGATDRDAEIYVVATDPSVQGHRVAGHLMATVLERLERDGVPGVELYVEADNAPALRLYENWGFEVSGRDVQLRATERG", "function": "Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.", "AFDB_id": "AF-C7MGB3-F1-model_v4" }, { "swissprot_id": "Q9VSK9", "sequence": "MGKDRGRGRRNNHSGPYNKSNWRGQKKDRPQNNGGGQRNSAPQQKSTLLETQVGITEFTNPEAPGFTGILKSRFSDFHVNEIDSNGKVLELNDLSVPKVAIVAVAENELDNWRKELEAVIGPEVWQDIANLAKAKNDPAIEQKVEIDVTTLDKEQRTQVHQMIKQLYKGKLLSTTIGQQQAKPKVQEEASLENKDAAEGETSTQKDSQVPAEEKKTIKVFKPKPGRGDKRWSFPADYVTFLVHKTNLVTSDVASTLAARLNLRPSQVNYSGIKDKRAKTTQKFSVKRRTPESILVAARSQRNVHIGNFGFESNTLKLGDLQGNRFRIALRHIAKEKREEIEQALQSLKERGFINYYGLQRFGNSASVPTYEVGVALLKHDYKLACELILKPRDSDVEFLRPIREEWWKNRDSAAAAAQIYGEKFIEKKLLDGLARFGESDYSSALRQIPRNMLMLYPHAYQSLIFNRIASRRIKEFGLKLIPGDLVYVEQDQSEASEEQAQQGEALEEQKEEEPNDEPLEVPEGDEAIEEESIFKRKVRPLTAEDIASGKYKLCDVVLPLPGHDITYPSNECGAWYEEMLAEVGLSSDQLKHKEKTYALAGAYRKMIISSSDLKWSFRMYNTPEDTLIASDWELLKNIPVAPEPAEAEANYMALLLEFSLPTAAYATMFLRELLKQDTSSASQTQLEKQAMAKEDNEKKAVGTQEEQMEVVKEVADEDGQETEQAETQGAEEAV", "function": "Pseudouridylate synthase that catalyzes pseudouridylation of RNAs, such as tRNAs and mRNAs.", "AFDB_id": "AF-Q9VSK9-F1-model_v4" }, { "swissprot_id": "Q5AV01", "sequence": "MAGSCTIDEHNHFGPIVGDACYGGLDFTLYFEEAFLSIFPAATLILAATVRCFLVRSASLKVRGGWLHTLKLLLLAPYSISQLLLLAFWMRSGTPKTDLTIASTVLRFIATLPCGYLIHLQHHRSLRPSKIISIYFLLTLLFDIPLARTIWTIQGLRTVSAIFIAGTVVKALLLILETWEKRRLVRPMYASPAPEDWTGVINRSLFWWINPLLFRGARTSLSVGDLFHLESCMLPDPDGKHRVVMHWENVTNKDKAGAMVVPIAKAFKWDLLAGVFPRLCQSGFIISQPFLVRATVELFVYRDRPDSRSKATLLIGAYALVYGGIAIATATAQHKTYRVITMMRAALVDMIFEKSTAINAHKNDDSAALTLMSTDIERITHCGRYIHDTWASLIEIGIALYLLYNELDTAGIAPIIIAFGCTVTAMKIAMMAGERQNLWIEAIQKRVAITAEMLGSMKGVKISGLTDLLFNKIQALREHEILASQKFRSLLIAVVGLSNFNTLMTPIVSFTIYAMGSGDAPNEILGSARALTSLTLFNLFAVFIGTLVESISETAMALECLDRIRNYLAQEAHQDPREVNSSPVTEKTPCIEAFEVDVGWKNGDESILHRLSYRIERHSLTMIVGAVGCGKTTLVKAMLGEVNCLTGKMKVNCDRMAYCGQDAWLTNGSIRENILGGSPYDPPWYSTVVAACGLEKDFTELTAGDQTAVGSKGVSLSGGQKQRLGSLDVLTRAQALARALYSGVETILLDDALSGLDPVTDEHIFTQVLGPNGLARKQHLTVVMVTHAVHRLPYADHIIALNTDGTILVQGTFDDCCKRLDYIQGFAIAQPPAIQMKSAMPKAVEVTKAAPYSDEAISDARRSSDYQTYLYYLTTVPWHNWLVYFGLMAIFVFLQAFPTVWVTWWARDNDAQPNKNRSMRIGVYWMFGVLGACFLLATACFYMLKIVAKTASVIHSRLLRTVVNAPMSFFASTDSGTTLNRFSQDLELIDMELPLAVLQTCLALFLCVAQLIIIAVSARYITATIPLCVLVYCIIGTFYMRTSRQLRIMEIEAKSPLFSNFMELLNGLITIRAFNWAEQYKLRNRALLAESQRPYYLLYAVQRWLSLVLDMTVAGFVLVLMGIAVGTMHSTNASSLGLALVNVVSLSASVKALITDWTVLETSLGAVTRVKHFAESTESEDMVQERDLPPEDWTSRGTVEYKNVSAFYRDPSKPVLKNLSFRVHKGEKVAIVGRSGSGKSTLVSALFRMIELCEGTISVDGIDITTLRRQAIRSAIIGLPQDPLLLEGSTIRENVDPFDYCPDEAVINTLKRVGLWEILESKDGLETIASPELFSHGQKQLLCMAKAMLRHGNIIVFDEATSGVDPETDEMMQELIRSCFAQHTVLTVTHRLDTIIDYDRVLVMDNGILLESDPPRTLLSRPSVFRELYKSSRGWEEYERQERAEAEARRRERVEKERAEEELRGRRGLISEKEEPETVSAIREHWNVVNQLFGGIIPRAVPRTRSRSRDHSAERRESKRYSGGDWTGEGDGDGGDGGLGRRDTRRHLTGLAARGLH", "function": "ABC transporter; part of the gene cluster that mediates the biosynthesis of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol).", "AFDB_id": "AF-Q5AV01-F1-model_v4" }, { "swissprot_id": "B9LMH0", "sequence": "MYEAVHAHPDGDATVARHAATAERYGYEGIVVRTREALDPASKSSEHADEATALRDEYGIDVVDAVEIDADNATSASGAVGNYRSDRTVVCVVGGDDGLNRFAVEEPRVDVLVRPMGGGDFNHVLAKAARDNGVHVEFDLGPLFRATGGKRVRALADLRKLREIVTYYDTPHVVSANPRSHLDLRAPREVVAAAEAVGFDAEWVREGLRAWGEIATRNRERRSEAFIEPGVRRGRYEEDG", "function": "Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.", "AFDB_id": "AF-B9LMH0-F1-model_v4" }, { "swissprot_id": "Q12158", "sequence": "MVTENPQRLTVLRLATNKGPLAQIWLASNMSNIPRGSVIQTHIAESAKEIAKASGCDDESGDNEYITLRTSGELLQGIVRVYSKQATFLLTDIKDTLTKISMLFKTSQKMTSTVNRLNTVTRVHQLMLEDAVTEREVLVTPGLEFLDDTTIPVGLMAQENSMERKVQGAAPWDTSLEVGRRFSPDEDFEHNNLSSMNLDFDIEEGPITSKSWEEGTRQSSRNFDTHENYIQDDDFPLDDAGTIGWDLGITEKNDQNNDDDDNSVEQGRRLGESIMSEEPTDFGFDLDIEKEAPAGNIDTITDAMTESQPKQTGTRRNSKLLNTKSIQIDEETENSESIASSNTYKEERSNNLLTPQPTNFTTKRLWSEITESMSYLPDPILKNFLSYESLKKRKIHNGREGSIEEPELNVSLNLTDDVISNAGTNDNSFNELTDNMSDFVPIDAGLNEAPFPEENIIDAKTRNEQTTIQTEKVRPTPGEVASKAIVQMAKILRKELSEEKEVIFTDVLKSQANTEPENITKREASRGFFDILSLATEGCIGLSQTEAFGNIKIDAKPALFERFINA", "function": "Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.", "AFDB_id": "AF-Q12158-F1-model_v4" }, { "swissprot_id": "P9WI08", "sequence": "MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGYASELSALTGAWSGPSSTSMASAAAPYVAWMSATAVHAELAGAQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALPTASQSASATPQWVTDLGNLSTFLGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLAEFALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAVGAAAAAVEDLATEANIFVIPAMDD", "function": "Could be required for host endothelial-cell invasion and/or intracellular survival.", "AFDB_id": "AF-P9WI08-F1-model_v4" }, { "swissprot_id": "P48607", "sequence": "MMTPMWISLFKVLLLLFAFFATYEAKEYERIIKELFTITNDEGVVLFNTSADSAPFMPIPTQHDDPTQKQKQNQNQSPIPETNRHYHQYHSLIQPDQYFKVQRSPNGKLNLVFNDTFVSLQRTDTEVQSEQPIPPRHPSDTFVFPDSPIAKYRPPQSPARPLRNDTKEHNPCAKDESQHLRNFCTNVDDYPDLSGLTHKLKNNFAKFFSNDLQPTDVSSRVGGSDERFLCRSIRKLVYPKKGLRADDTWQLIVNNDEYKQAIQIEECEGADQPCDFAANFPQSYNPICKQHYTQQTLASIKSDGELDVVQNSFKIPSCCKCALKTG", "function": "The activated form, spaetzle C-106, acts as a ligand for the Toll receptor. Binding to Toll activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin. Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo.", "AFDB_id": "AF-P48607-F1-model_v4" }, { "swissprot_id": "Q24509", "sequence": "MQTRRRLHQTDQQDYSSSSTYTIQEDQQGGAGAGSVGTGTAGGSVGLLAQSLVPPPTGHEAAIHIGDNYQSGDSISTPDYSDDKYGKAARQWNLRAFSGHALRTLSAAAAVVTGNQPGINNDSQSNYSYPASIPTSSQFYQSKEEPQETEPEPEIFVMAARDRTGEFANAIRSLQARNITRAVNIRDPRKAKQVQSYSEFMMVARFIGKNIASTYAKLEKLTMLAKKKSLFDDRPQEIQELTYIIKGDLNALNQQIARLQDISKDQRRHTNGKHLVSHSSNMVLALQSKLASMSTDFKQILEVRTENLKQQKTRRDQFSQGPGPLAAHTVSPSTAKQGSLLLSEENQAVSIDMGSSDTTPLLSTQTQMAIYDDSDNYVQQRAETMQNIESTIVELGGIFQQLAHMVKEQEEIVERIDTNVADAELNIEAAHGEILKYFQSVSKNRWLMIKIFGVLIFFFLFFVVFMS", "function": "Mediates endoplasmic reticulum to Golgi transport.", "AFDB_id": "AF-Q24509-F1-model_v4" }, { "swissprot_id": "Q7VR84", "sequence": "MTIFQKSFILLIIWNFSLFAFSDMKIEITHGINTAHPIAVIPFINNENITHELNNDNIEDIASIIAADLRNSGKFNTLPIAYLPYQPSKLTDIIPTFWEKLGINTVVLGAINIKNENYVISYQLIDTSNNPALVILDNQYEIEKKHLRYTAHTISDEIFEKLTGIKGVFCTRIAYILYTNNIKYAYELCTSDYDGHNQVSICRSSEPLMSPAWSPDGKKLAYVTFASGHSELIIQTLTNRSIDNIIQFPNHNGAPAWSPDGKKLAFSLSKTGSLNLYIMDLSSNNIQQITSNRYNNTEPSWFPDSQNLAYTSDQGGVPQVYKININNNRDSHRISWLNGSNQKPNISMDGTFMVMVNRNKGKQYISKLNFLTGEEETLTADSVLADTPSISPNGIMFMYSSIILNNSSSELYLDKKFTNIPDNNQSILSLASIDGKFKAHLNGSTGSIRFPTWSSLSCSY", "function": "Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.", "AFDB_id": "AF-Q7VR84-F1-model_v4" }, { "swissprot_id": "Q6B8Q1", "sequence": "MTYKNILDKLVGKWIHQRTSYFIHNQQIDYHQEEIKLKQIDNIYISTKDNNSLYQYELSNKINNQKIYYIFSKQEESEFGKLHKITNDEIKYYRFTIHTHNCIKIESVRENISYNEYIYLINNRFKITISILKRGQKYLATSFISEIKIFN", "function": "Might function to covalently attach a chromophore to Cys residue(s) of phycobiliproteins.", "AFDB_id": "AF-Q6B8Q1-F1-model_v4" }, { "swissprot_id": "Q54N40", "sequence": "MFMFNFDNGHDPNRPSFFEMLNQHQMMPSFKPALKYIFTVLSQRNPKFRYIVNYYDECFYSLLLLLEYHYLKYYEGSFSENFYNLKRIKPRNNNANGDGDTLFSLLKRLVVTPSNAGQGPETYTKSQILKKSFAMIRRNRAAASSSQQAKDDLNTMIQDSDRKESLIYLVLIPYFKGKLDEYYKKESDPLAELGLVSSDNNNNNNDNINDQIQQLEEQIQQQQTIVNGNNNSNNNNKKLKIKFLILIRFLKGSKTLKKLKTIFLKVYPFISAIYEALFFIYQLLYLYEYTNYYTPFFHFQNIQLKRLNHKDIESHRVVISNRRRDRINFVRDWPGSSFFVRLVSILDSILDYSKYILPLSVFIFKSLEWWYSENRISAPTLPIPTPPTPSKRAPGGLEIPRDKRLCPLCLKERTNPTICGSGFVFCYPCIFGYVNEHSKCPITFLPTNTEQLRKIYETV", "function": "Required for protein import into peroxisomes.", "AFDB_id": "AF-Q54N40-F1-model_v4" }, { "swissprot_id": "O94494", "sequence": "MNSENASLFRNILNDTENLVQPLTQDESRLALFESLVQSDQLLVEKIEKWEKKVSKFTENSKSEKRKLQLELFQEIIDLKKCIAFKPIIGKNAIDNNISDLKKNLHSNKKLEAVLKEELHQIKKFSSDLQSLKSSMGERQKQQAAMSRRGKKSIIHSAIIQEKERYEKESQELFTFLDGFLDEHAPSLLEGAQASIDKNRPGKNQPSLNFENISKKDLTEEFKQVIENLMNNSIIPGSPYIEVKNERIVSFLVLASLCTVDPQDPSKVKLIPFSDEI", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.", "AFDB_id": "AF-O94494-F1-model_v4" }, { "swissprot_id": "A7TJY9", "sequence": "MIEMNNISYIKGNILHGGNIPRILIHSCNCNGTWGGGIAYQLAVHYPEAEKIYTDICDDFGSELLGKCVLIPSFSDDSLLIGCLFTSVYGGSSHDTKNEILKYTKLSLMQLSLQLENNDSCIDTCLSEYNQLLISNIKHHLKDYKLEMPKINSGIFNVPWEETEKILKELKPMEFTVFSI", "function": "Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.", "AFDB_id": "AF-A7TJY9-F1-model_v4" }, { "swissprot_id": "Q9RTJ3", "sequence": "MPDPAARRFSLPPFPLAALALSVALLGAPASLAQTAAPAPAPAQTPAAASRAAAPRVSWTKPLKVSSPVSIGPRGELTYVGNDSRVHRTDASGKELWSFALGDIGRAQPVLTPDGGVITAAYDDTVYALSPAGQLTWKAKLDGDVFASPALRPDGSVVVATAGGTVYALSSSGQTLWSYKVGAPVFSSPAVAADGTIYFGAQNGRLHALSPEGRLTWTYAARSSVFSSPALDAEGNLYFGSGDRSIYSLSPAGTLRWVQPTGLFVNASPIVTRAGLVVVGSYDGQLYALNTNGQVAWTYAAGAAIAAPAAELSDGSVVVGDLNGTLHAVTPTGQALWTLPGGAKIDTGAAVSDQGTLYFAVDGGNLNAVENLRPLATGPWPTFRASPLGWGRSATAAELTAQTQARQAAAAASTSQQPRLPTLAQAPAPTPAPAQTTPRPQPTPAQPATPAAPVPPVASPAPATARLTPQVIGGVIYLPLSPIAAGLGYQVQAGSPTRALLVAGSQRLTVPVRAVGGQSLIALRFVTGLPGVSVERQAGTLTLRREGLSAALPLDLAQLLPWAPQPEFPGVVRR", "function": "Plays an important role in resistance to desiccation and radiation, maybe by protecting genome integrity under extreme conditions.", "AFDB_id": "AF-Q9RTJ3-F1-model_v4" }, { "swissprot_id": "Q9LR65", "sequence": "MGGCISKTSWSNEEPMHRPCLGMGCCGSKMGKRGFSDRMVSLHNLVSIPNRIIGNGKSRSSCIFTQQGRKGINQDAMIVWEDFMSKDVTFCGVFDGHGPHGHLVARKVRDSLPVKLLSLLNSIKSKQNGPIGTRASKSDSLEAEKEESTEEDKLNFLWEEAFLKSFNAMDKELRSHPNLECFCSGCTAVTIIKQGSNLYMGNIGDSRAILGSKDSNDSMIAVQLTVDLKPDLPREAERIKQCKGRVFALQDEPEVSRVWLPFDNAPGLAMARAFGDFCLKDYGVISIPEFSHRVLTDRDQFIVLASDGVWDVLSNEEVVEVVASATSRASAARLVVDSAVREWKLKYPTSKMDDCAVVCLFLDGRMDSETSDNEEQCFSSATNAVESDESQGAEPCLQRNVTVRSLSTDQENNSYGKVIAEADNAEKEKTREGEQNWSGLEGVTRVNSLVQLPRFPGEEPKT", "function": "May act as negative regulator of GCN5.", "AFDB_id": "AF-Q9LR65-F1-model_v4" }, { "swissprot_id": "P9WPJ0", "sequence": "MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGFSHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGPHLHGVLMESIPADYVQTLHTVPVNPYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRSLEQNPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGEEPDPGLIAEFGQSVRLSAFRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLWFGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP", "function": "CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units.", "AFDB_id": "AF-P9WPJ0-F1-model_v4" }, { "swissprot_id": "Q9SRR0", "sequence": "MASQPAGGSPPKPWEKEGNTSGPNPFRPPSNTSTAGSVEASGTANPGEVVPPPVNRPNTAANMNSLSRPVPARPWEQQNYGSTMGGGYGSNLGMTSGYGSGTYGSALGGYGSSYGGGMYGGSSMYRGGYGGGGLYGSSGMYGGGAMGGYGGTMGGYGMGMGTGMGMGMGMGMGGPYGSQDPNDPFNQPPSPPGFWISFLRVMQGAVNFFGRVAMLIDQNTQAFHMFMSALLQLFDRGGMLYGELARFVLRMLGVRTRPRKMQQPPQGPNGLPLPHQPHGNQNYLEGPKTAAPGGGGGWDNVWGN", "function": "Involved in PTS1- and PTS2-dependent protein import into peroxisomes. Required for PTS1-dependent protein import into pollen peroxisomes. Acts as a docking factor on peroxisomal membranes. Required for the proper targeting of PEX7 to the peroxisome. Required for the export/release of receptors on the peroxisome membrane. Essential for pollen-tube discharge that take place only in the presence of functional peroxisomes in either the male or the female gametophyte.", "AFDB_id": "AF-Q9SRR0-F1-model_v4" }, { "swissprot_id": "Q939X3", "sequence": "MGVDVSMTTSIEPAEDLSVLSGLTEITRFAGVGTAVSASSYSQSEVLDILDVEDPKIRSVFLNSAIDRRFLTLPPESPGGGRVSEPQGDLLDKHKELAVDMGCRALEACLKSAGATLSDLRHLCCVTSTGFLTPGLSALIIRELGIDPHCSRSDIVGMGCNAGLNALNVVAGWSAAHPGELGVVLCSEACSAAYALDGTMRTAVVNSLFGDGSAALAVISGDGRVPGPRVLKFASYIITDALDAMRYDWDRDQDRFSFFLDPQIPYVVGAHAEIVADRLLSGTGLRRSDIGHWLVHSGGKKVIDSVVVNLGLSRHDVRHTTGVLRDYGNLSSGSFLFSYERLAEEGVTRPGDYGVLMTMGPGSTIEMALIQW", "function": "Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of balhimycin antibiotic. Catalyzes the Claisen condensation of four molecules of malonyl-CoA to yield 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) and three free coenzyme A (CoA). DpgA requires the presence of the dehydratases DpgB and DpgD to facilitate the aromatization of the DPA-S-DgpA or DPA-S-CoA intermediate.", "AFDB_id": "AF-Q939X3-F1-model_v4" }, { "swissprot_id": "P86231", "sequence": "MFHLRTCAAKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRLGFYGLHESDLDKSTRFEEFLQRGRLNVLANVIRYHLGMYHRRSSPYPTDVARICEEAFTRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVYYDLTRAKPVWYAGRKTHLTELQRFLDTAFDLDAFKK", "function": "2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.", "AFDB_id": "AF-P86231-F1-model_v4" }, { "swissprot_id": "Q9H3H9", "sequence": "MEKLFNENEGMPSNQGKIDNEEQPPHEGKPEVACILEDKKLENEGNTENTGKRVEEPLKDKEKPESAGKAKGEGKSERKGKSEMQGGSKTEGKPERGGRAEGEGEPDSEREPESEGEPESETRAAGKRPAEDDIPRKAKRKTNKGLAQYLKQYKEAIHDMNFSNEDMIREFDNMARVEDKRRKSKQKLGAFLWMQRNLQDPFYPRGPREFRGGCRAPRRDTEDIPYV", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q9H3H9-F1-model_v4" }, { "swissprot_id": "P64420", "sequence": "MHEITLCQRALELIEQQASAYGAKRVTAVWIKIGAFSCVETSALSFCFDLVCRGTIAEGCKLHLEEQEAECWCEHCQQYVTLLTHRVRRCPQCHSDTLRIVADDGLQIRRIEIDETED", "function": "Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.", "AFDB_id": "AF-P64420-F1-model_v4" }, { "swissprot_id": "Q6P050", "sequence": "MWPLLTMHITQLNRECLLHLFSFLDKDSRKSLARTCSQLHDVFEDPALWSLLHFRSLTELQKDNFLLGPALRSLSICWHSSRVQVCSIEDWLKSAFQRSICSRHESLVNDFLLRVCDRLSAVRSPRRREAPAPSSGTPIAVGPKSPRWGGPDHSEFADLRSGVTGARAAARRGLGSLRAERPSETPPAPGVSWGPPPPGAPVVISVKQEEGKQGRTGRRSHRAAPPCGFARTRVCPPTFPGADAFPQ", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).", "AFDB_id": "AF-Q6P050-F1-model_v4" }, { "swissprot_id": "P47285", "sequence": "MQTIDVLIVGGGVIGTSCAYELSQYKLKVALLEKNAFLGCETSQANSGVIHSGIDPNPNKLTAKYNILGRKIWIEDWFKKLIFPRKKIATLIVAFNNEEKLQLNLLKERGIKNSIPVENIQILDQQQTLLQEPFINPNVVASLKVEGSWLIDPLIATKCLALASLQNNVAIYSNKKVTKIEIDSDDDFLVFINNETTPQFKTKKLIDAAGHYADWLAETTQVDNFKQTTRKGQYLVLKNQNNLKINTIIFMVPTIHGKGVVVAEMLDGNILVGPNAVEGIEKNKTRSIDLDSINQIKTIGKKMVPSLQFENSIYSFAGSRAIDIETNDFVIRTAKSNPNFIILGGMKSPGLTSSPAIAKRAVELLNLKLKKKINWNPNYNLSWI", "function": "Catalyzes the oxidation of glycerol 3-phosphate to dihydroxyacetone phosphate (DHAP), with a reduction of O2 to H2O2. The formation of hydrogen peroxide by this enzyme is crucial for cytotoxic effects on host cells. Does not show any dehydrogenase activity with NAD(+).", "AFDB_id": "AF-P47285-F1-model_v4" }, { "swissprot_id": "B7VGF9", "sequence": "MKFFIFTCLLAVALAKHNMEHRSSSEDSVNISQEKFKQEKYVVIPTSKESICSTSCEEATRNINEMESAKFPTEVYSSSSSSEESAKFPTEREEKEVEEKHHLKQLNKINQFYEKLNFLQYLQALRQPRIVLTPWDQTKTGASPFIPIVNTEQLFTSEEIPKKTVDMESTEVVTEKTELTEEEKNYLKLLNKINQYYEKFTLPQYFKIVHQHQTTMDPQSHSKTNSYQIIPVLRYF", "function": "Important role in the capacity of milk to transport calcium phosphate.", "AFDB_id": "AF-B7VGF9-F1-model_v4" }, { "swissprot_id": "P06105", "sequence": "MSEEQTAIDSPPSTVEGSVETVTTIDSPSTTASTIAATAEEHPQLEKKPTPLPSLKDLPSLGSNAAFANVKVSWGPNMKPAVSNSPSPSPSAPSLTTGLGAKRMRSKNIQEAFTLDLQSQLSITKPELSRIVQSVKKNHDVSVESTLSKNARTFLVSGVAANVHEAKRELVKKLTKPINAVIEVPSKCKASIIGSGGRTIREISDAYEVKINVSKEVNENSYDEDMDDTTSNVSLFGDFESVNLAKAKILAIVKEETKNATIKLVVEDEKYLPYIDVSEFASDEGDEEVKVQFYKKSGDIVILGPREKAKATKTSIQDYLKKLASNLDEEKVKIPSKFQFLIDAEELKEKYNVIVTFPSTPDDELVSFVGLRDKVGEAITYARSSSKSYVVESLDISKAHSKNLTHAKNLIMYFTKYSVLKGLEESHPNVKISLPSIQSLPTAETVTIHISAKSDEANDIKAVRKELISFVNNIPPSETLVITDLDYELFGGSIKHCLLASESSVAFVQFGDYYPNDNSILLVALTEDEDFKPSIEEIQASLNKANESLNSLRTKQNNMETKTYEFSEEVQDSLFKPSSATWKLIMEDISEQEGHLQIKLHTPEENQLTVRGDEKAAKAANKIFESILNSPSSKSKMTVNIPANSVARLIGNKGSNLQQIREKFACQIDIPNEENNNASKDKTVEVTLTGLEYNLTHAKKYLAAEAKKWADIITKELIVPVKFHGSLIGPHGTYRNRLQEKYNVFINFPRDNEIVTIRGPSRGVNKAHEELKALLDFEMENGHKMVINVPAEHVPRIIGKNGDNINDIRAEYGVEMDFLQKSTDPKAQETGEVELEITGSRQNIKDAAKRVESIVAEASDFVTEVLKIDHKYHKSIVGSGGHILREIISKAGGEEIRNKSVDIPNADSENKDITVQGPQKFVKKVVEEINKIVKDAENSVTKTIDIPAERKGALIGPGGIVRRQLESEFNINLFVPNKDDPSGKITITGAPENVEKAEKKILNEIIRENFDREVDVPASIYEYVSERGAFIQKLRMDLSVNVRFGNTSKKANKLARAPIEIPLEKVCGSTEGENAEKTKFTIEEVGAPTSSEEGDITMRLTYEPIDLSSILSDGEEKEVTKDTSNDSAKKEEALDTAVKLIKERIAKAPSATYAGYVWGADTRRFNMIVGPGGSNIKKIREAADVIINVPRKSDKVNDVVYIRGTKAGVEKAGEMVLKSLRR", "function": "Involved in the control of mitotic chromosome transmission. Required during cell division for faithful partitioning of the ER-nuclear envelope membranes which, in S.cerevisiae, enclose the duplicated chromosomes.", "AFDB_id": "AF-P06105-F1-model_v4" }, { "swissprot_id": "O65837", "sequence": "MECVGVQNVGAMAVLTRPRLNRWSGGELCQEKSIFLAYEQYESKCNSSSGSDSCVVDKEDFADEEDYIKAGGSQLVFVQMQQKKDMDQQSKLSDELRQISAGQTVLDLVVIGCGPAGLALAAESAKLGLNVGLVGPDLPFTNNYGVWEDEFKDLGLQACIEHVWRDTIVYLDDDEPILIGRAYGRVSRHFLHEELLKRCVEAGVLYLNSKVDRIVEATNGQSLVECEGDVVIPCRFVTVASGAASGKFLQYELGSPRVSVQTAYGVEVEVDNNPFDPSLMVFMDYRDYLRHDAQSLEAKYPTFLYAMPMSPTRVFFEETCLASKDAMPFDLLKKKLMLRLNTLGVRIKEIYEEEWSYIPVGGSLPNTEQKTLAFGAAASMVHPATGYSVVRSLSEAPKCASVLANILRQHYSKNMLTSSSIPSISTQAWNTLWPQERKRQRSFFLFGLALILQLDIEGIRSFFRAFFRVPKWMWQGFLGSSLSSADLMLFAFYMFIIAPNDMRKGLIRHLLSDPTGATLIRTYLTF", "function": "Catalyzes the single cyclization reaction which converts lycopene to delta-carotene and neurosporene to alpha-zeacarotene. Required for lutein biosynthesis.", "AFDB_id": "AF-O65837-F1-model_v4" }, { "swissprot_id": "Q10484", "sequence": "MALECDSTIVFPRPLTRLVKCDLELRNTAPYPIGFKVKTTAPKQYCVRPNGGRIEANSAVSVEVILQPLDHEPAPGTKCRDKFLVQSTELKPELQGMDIADIWTQVSKANISERKIRCVYSEGPSTANAHANAHHQPAQTTTTSIPTSATDNYTTVNGNVNQSYSKGIDGTALPSTHANPVAAPSTATTQHTQLPKTSAVSHQKPHEAPSTAVKAPTATVAENEPYPKPQSVPTTTSPNNENNALRSTANVINNTRQSTATSPSMFAGNSGNQIGLARVSSSFGRPTSGAKVVPQIHNTVTVQTAFLLAIICFLIGLLF", "function": "Vesicle-associated membrane protein-associated protein (VAP) implicated in maintaining the cortical endoplasmic reticulum (ER)-plasma membrane (PM) attachment. ER-PM contacts function to modulate the distribution of contractile ring components to ensure robust ring assembly. ER-PM contacts function also in controlling exocytosis and maintenance of cell polarity regulating cell shape. VAPs play an important role in regulating eisosome assembly. VAPs also contribute to ER-phagy by tethering atg8 to the ER membrane, but also by maintaining the ER-plasma membrane contact (Ref.7).", "AFDB_id": "AF-Q10484-F1-model_v4" }, { "swissprot_id": "F4I8S3", "sequence": "MECIGKRVKSRSWQRLQAVNKRKKMETVAPVTSPPKKRRQKKPKNYDSDIEDITPTCNDSVPPPQVSNMYSVPNNSVKESFSRIMRDLNVEKKSGPSSSRLTDGSEQNPCLKERSFRVSDLGVEKKCSPEITDLDVGIPVPRFSKLKDVSEQKNTCLMQKSSPEIADLDLVISVPSSSVLKDVSEEIRFLKDKCSPEIRGLVLEKSVPGEIEILSDSESETEARRRASAKKKLFEESSRIVESISDGEDSSSETDEEEEENQDSEDNNTKDNVTVESLSSEDPSSSSSSSSSSSSSSSSSSSDDESYVKEVVGDNRDDDDLRKASSPIKRVSLVERKALVRYKRSGSSLTKPRERDNKIQKLNHREEEKKERQREVVRVVTKQPSNVVYTCAHCGKENTGNPESHSSFIRPHSIRDEIEDVNNFASTNVSKYEDSVSINSGKTTGAPSRPEVENPETGKELNTPEKPSISRPEIFTTEKAIDVQVPEEPSRPEIYSSEKAKEVQAPEMPSRPEVFSSEKAKEIQVPEMPSIPEIQNSEKAKEVQANNRMGLTTPAVAEGLNKSVVTNEHIEDDSDSSISSGDGYESDPTLKDKEVKINNHSDWRILNGNNKEVDLFRLLVNSVWEKGQLGEEDEADELVSSAEDQSQEQAREDHRKYDDAGLLIIRPPPLIEKFGVEEPQSPPVVSEIDSEEDRLWEELAFFTKSNDIGGNELFSNVEKNISANETPAAQCKKGKHDLCIDLEVGLKCMHCGFVEREIRSMDVSEWGEKTTRERRKFDRFEEEEGSSFIGKLGFDAPNNSLNEGCVSSEGTVWDKIPGVKSQMYPHQQEGFEFIWKNLAGTIMLNELKDFENSDETGGCIMSHAPGTGKTRLTIIFLQAYLQCFPDCKPVIIAPASLLLTWAEEFKKWNISIPFHNLSSLDFTGKENSAALGLLMQKNATARSNNEIRMVKIYSWIKSKSILGISYNLYEKLAGVKDEDKKTKMVREVKPDKELDDIREILMGRPGLLVLDEAHTPRNQRSCIWKTLSKVETQKRILLSGTPFQNNFLELCNVLGLARPKYLERLTSTLKKSGMTVTKRGKKNLGNEINNRGIEELKAVMLPFVHVHKGSILQSSLPGLRECVVVLNPPELQRRVLESIEVTHNRKTKNVFETEHKLSLVSVHPSLVSRCKISEKERLSIDEALLAQLKKVRLDPNQSVKTRFLMEFVELCEVIKEKVLVFSQYIDPLKLIMKHLVSRFKWNPGEEVLYMHGKLEQKQRQTLINEFNDPKSKAKVFLASTKACSEGISLVGASRVILLDVVWNPAVERQAISRAYRIGQKRIVYTYHLVAKGTPEGPKYCKQAQKDRISELVFACSSRHDKGKEKIAEAVTEDKVLDTMVEHSKLGDMFDNLIVQPKEADLVEGFSILMP", "function": "Probable chromatin remodeling factor.", "AFDB_id": "AF-F4I8S3-F1-model_v4" }, { "swissprot_id": "A6Q573", "sequence": "MIRLASTSETRAKLLQDTGIEFIQSPVDFDEEELLKVYKNPRDFVCAAARGKMEAAVEKYGLEIPIVAADTVVAVSDEILRKAKDEEEARKILQKQSGNKVDIITCMIYKDKEKTVEDLDVTSYIFAPFDEEDLQNYLKSGQWRGKAGACMVEGFCKKYIKEVLGRESTAMGLQVERLAEIAKDL", "function": "Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.", "AFDB_id": "AF-A6Q573-F1-model_v4" }, { "swissprot_id": "E4TI44", "sequence": "MLTSKNNFHKVAPFYEQNALIQKKMAERLMELVEKNVGCEFDDVLEIGCGTGLFTKLIQKKINYNRLFLNDLHNFISFEGGYDFLEGDIEEINLSDKFDIIFSNATFQWVKDFEQLIQKLYQSLKPQGYLCFTTFGEENLKEVKRITNVGLNYLTFNEYLDFLGRYFKIVAHYHTKECLYFQSPVDVLKHMKLTGVNSVEKVQWTKRDFVNFCESYEQFKTEEGYLLTYHPFYFIVSKNKEVCYD", "function": "Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.", "AFDB_id": "AF-E4TI44-F1-model_v4" }, { "swissprot_id": "P34707", "sequence": "MGGSSRRQRSTSATRRDDKRRRRQCFSSVADDEEETTSIYGVSSIFIWILATSSLILVISSPSSNTSIQSSSYDRITTKHLLDNISPTFKMYTDSNNRNFDEVNHQHQQEQDFNGQSKYDYPQFNRPMGLRWRDDQRMMEYFMSNGPVETVPVMPILTEHPPASPFGRGPSTERPTTSSRYEYSSPSLEDIDLIDVLWRSDIAGEKGTRQVAPADQYECDLQTLTEKSTVAPLTAEENARYEDLSKGFYNGFFESFNNNQYQQKHQQQQREQIKTPTLEHPTQKAELEDDLFDEDLAQLFEDVSREEGQLNQLFDNKQQHPVINNVSLSEGIVYNQANLTEMQEMRDSCNQVSISTIPTTSTAQPETLFNVTDSQTVEQWLPTEVVPNDVFPTSNYAYIGMQNDSLQAVVSNGQIDYDHSYQSTGQTPLSPLIIGSSGRQQQTQTSPGSVTVTATATQSLFDPYHSQRHSFSDCTTDSSSTCSRLSSESPRYTSESSTGTHESRFYGKLAPSSGSRYQRSSSPRSSQSSIKIARVVPLASGQRKRGRQSKDEQLASDNELPVSAFQISEMSLSELQQVLKNESLSEYQRQLIRKIRRRGKNKVAARTCRQRRTDRHDKMSHYI", "function": "Directed by the ER-associated degradation pathway (ERAD), mediates proteasomal homeostasis by regulating the expression of proteasomal subunits such as rpt-3 to confer resistance to proteasomal dysfunction.", "AFDB_id": "AF-P34707-F1-model_v4" }, { "swissprot_id": "Q6C354", "sequence": "MRAFRSAANFGAASNIYRKSFTPASIASNRFVSARMSSIMTDNARPNTDKVVQDIADYIHDYKIDSSVAMETARLCFLDTLGCGLEGLKYQQCANIVGPVVPGTIVPNGTKVPGTDYQVDPVRGAFNIGTIIRWLDFNDCWLAAEWGHPSDNLGGILAVADWQTRSAKAGLEGKVFKVKDVLEGMIKAHEIQGGLAIENSFNRVGLDHVVLVKIASTAVVSGMLGLSREQTADAISQAFVDGQSLRTYRHAPNTMSRKSWAAGDATSRAVNLALLVKKGEGGMPSILTAKTWGFYDVLFGGKEFKFQRPYGSYVMENVLFKISFPAEFHAQTACESAMLLHEELKKLGKTSDDIASIKIRTQEAAMRIIDKKGPLHNYADRDHCIQYMVAIPLIHGRLTADDYTDEIASDPRIDALREKMECVEDKRFSEEYHAPDKRYIGNAIEITLKDGTVLDEIEVNYPIGHRQRREEGTPVLLEKFARHLRGRFPEGQVEKILAASNQDIVNMDIDEYVDLYVKKD", "function": "Component of the methylcitrate cycle that catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate. The methylcitrate cycle is a metabolic pathway for the consumption of propionic acid.", "AFDB_id": "AF-Q6C354-F1-model_v4" }, { "swissprot_id": "Q7SB49", "sequence": "MNTNRRSRSPDEEALEEDQHQYGAGTLSLEELDEHFPNRPRNHSKTFPFSDLFRTLFNPLIDCKPSTSGGTVRGPKPGRGGHFSKVSYHEQRRHIIERFMSRWRSEVGNDFYPAMRLILPDKDRDRGVYGLKENTIGKLLVKVMKIDRNSEDGYNLMHWKLPGGQSGVSRSVGDFAGRCLEVVSKRAMRAQPGDLTIADVNVLLDRLAAASGEAEQLPIFEEFYRQMNAEEMMWLVRIILKDMRVGATERTFLNLWHPDAEALFSVSSSLRRVCWELFDPEFRLEQQETGIKLMQCFQPQLAQFQMTTTWEKLVKNLGVTEENPEFWIEEKLDGERMQMHMIEDDTVPGGFRFAFWSRKAKDYTYLYGESLGDEQSALTRHLHKAFDDGVRNLILDGEMITWDIDIDKMVPFGTLKTAALEQQKNPSKAGPRPLYRVFDILLLNDKPLTEYTLNDRRRALERAVVGVHRRLEILPFERATSPDAIEPLLRRVVAEASEGLVLKNPRSRYSLNSRNNDWIKVKPEYMSDFGESLDCVVVGGYFGSGRRGGTLSSFLCGVRVSQNFIKSGNASAEKCLSFVKVGGGFKAEDYAEIRHHTEGKWQDWDPSSPPTEYIELGGGEKLQYEKPDVWIRPSDSVVISVKAASITQSDQFAMGWTLRFPRFRKLRLDRAWDSALDMDEFEVLRSKIKDQEQERKKMEMENRKRKPATKRARKDLVIAGMSDPSSSSAATPVIAPKETREASKRLFEGLDFCVLSDSLKPNKMTKPALEKLIKDHGGRIHQQVMDHSGQGKIIIPIADKNVIKVASLRKANPEMDIIRPKWIFDCLVQPMPFTKQKENKKGYLLPFEPTHLFHSGSEETSEEAEQAVDKFGDSYAGDLADINELKAIMEGMESDDYVSDSDWDSDSGRGRGGGDGFDMNHFLDHLEEQGTSLDDLRSFMFRRCRVFFALPSAGNGDGAAESKALRLKNYIRFGNGKVVDELETATHVVVVTAPLGESSKKEEREIAAELRYKISLREMGSPMPRIVKGEWVEDSWKEGTVVDEEEYVAG", "function": "Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.", "AFDB_id": "AF-Q7SB49-F1-model_v4" }, { "swissprot_id": "Q69KN0", "sequence": "MCRHQPRARLSPDEQLAAEESFALYCKPVELYNIIQRRSIKNPAFLQRCLLYKIHARRKKRSLITISLSGGTNKELRAQNIFPLYVLLARPTNNVSLEGHSPIYRFSRACLLTSFHEFGNKDYTEATFVIPDVKNLATSRACSLNIILISCGRAEQTFDDNNCSGNHVEGSTLQKLEGKCFWGKIPIDLLASSLGNCVSLSLGHTVEMSSTVEMTPSFLEPKFLEDDSCLTFCSQKVDATGSFQLQVSISAQEAGAKDMSESPYSVYSYNDVPPSSLTHIIRLRSGNVLFNYKYYNNTMQKTEVTEDFSCPFCLVPCGSFKGLGCHLNASHDLFHYEFWISEECQAVNVSLKTDSWRTELLAEGVDPRHQTFSYRSRFKKRKRVEISSDKIRHVHPHIVDSGSPEDAQAGSEDDYVQRENGSSVAHASVDPANSLHGSNLSAPTVLQFGKTRKLSVERADPRNRQLLQKRQFFHSHRAQPMALEQVFSDRDSEDEVDDDIADFEDRRMLDDFVDVTKDEKLIMHMWNSFVRKQRVLADGHIPWACEAFSQFHGQELVQNPALLWCWRFFMVKLWNHSLLDARAMNACNTILEGYLNGSSDPKKN", "function": "Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They act via the methylation of histones, rendering chromatin heritably changed in its expressibility (Probable). Polycomb group (PcG) protein involved in the repression of flowering under long day (LD) conditions. Regulates floret development.", "AFDB_id": "AF-Q69KN0-F1-model_v4" }, { "swissprot_id": "Q3AS33", "sequence": "MNATAIIAASGIGKRMKLANGGCKQMLEIGGFSVIYHTLKAFEQAPSIHNIYLATRAESIPLIQELAASANIGKLTAVVEGGKERQDSINNCIKAIEVKRHQSGVTPDVILVHDGARPFIQPEEIEEIARLSLLFGACVPATRPKDTIKFIGHDPEFFGETLDRNRLVQVQTPQGFRSELLMQAHQQAEAEGWYSTDDAALVERFFPQQLIKIFEMGYHNIKITTPEDILVAEAIYQQLQAHGNATSEAASAS", "function": "Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).", "AFDB_id": "AF-Q3AS33-F1-model_v4" }, { "swissprot_id": "Q3MKY2", "sequence": "MGFARLLHLVFSLLVFAGITNGLICPFDSIYQLGDSFSDTGNLIRLPPDGPTFTAAHFPYGETFPGTPTGRCSDGRLIIDFIATALNLPLLNPYLQQNVSFRHGVNFAVAGATALDRSFLAARGVQVSDIHSHLSAQLNWFRTYLGSICSTPKECSNKLKNALFILGNIGNNDVNYAFPNRTIEEIRAYVPFITEAVANATREIIRLGGSRVIVPGIFPIGCVARNLNFLNFFPDGDKDDLGCLSSLNNLSIYFNSLFQRALASLSIEFPQAVIIYADYYNAWRFLFRNGPALGSNSTSLLKCCCGIGGPYNYDPDRECGSRGVPVCPNPTQYIQWDGTHFTQAAYRRVAEYVIPGIIKALKCSYSNIQPFLREGEGRQALRLNERE", "function": "Deacetylates 17-O-acetylajmaline and 17-O-acetylnorajmaline, but is inactive toward other acetylated alkaloids.", "AFDB_id": "AF-Q3MKY2-F1-model_v4" }, { "swissprot_id": "Q9V3U9", "sequence": "MKIWTSEHIFNHPWETVTQAAWRKYPNPMTPSIIGTDVVERRVVDGVLHTHRLVQSKWYFPKWTHALIGTAKTCFASERSTVDPERKQMVLKTNNLTFCRNISVDEVLYYEPHPSDASKTLLKQEATVTVFGVPLSHYMEDLLTSTISTNAGKGRQGLEWVIGLINTEVKGIARGTDELLHNTRRSIDEVTESARKSMDEISAQAAKAAKAMHIT", "function": "Required to regulate peristaltic movement and also for germline proliferation in males and females.", "AFDB_id": "AF-Q9V3U9-F1-model_v4" }, { "swissprot_id": "P31705", "sequence": "MAQYHYQALDAQGKKCRGTQEADSARQARQLLRERGLVPLSVDENRGDQQKSGSTGLSLRRKIRLSTSDLALLTRQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSLADAMKCFPGSFERLYCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLTVVAIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLMGMSDAVRTFGPWMLLALLAGFMAFRVMLRQEKRRVSFHRRLLHLPLIGRIARGLNTARYARTLSILNASAVPLLQAMRISGDVMSNDYARHRLSLATDAVREGVSLHKALEQTALFPPMMRHMIASGERSGELDSMLERAADNQDREFSSQMTLALGLFEPLLVVSMAAVVLFIVLAILQPILQLNTLMSS", "function": "Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.", "AFDB_id": "AF-P31705-F1-model_v4" }, { "swissprot_id": "Q6ZJM9", "sequence": "MGSQNRPPPPRKRQPPPPEDHLVTYKRRRSKETQPLPLMANGANSKKDAKAQHWISWRDTLHGFLQSPAISQGGGIQTCIRHALQHNPCLLTNGVVVHTEFKGNPAHSQGEEAKVQHPNGAAGGKVVSADAAIQDAAAAASSEANKAMCNNALFDILVSQKFALLCHLLLGTFHVNKPGDVIDLEKIDAKMRNGDYAHNPALFDDDIQQMWEKFEQVGQEMTGLASNLSTISRVSYQKQASGFSEAEVAEHRIEEISLPGAVHVVTKESTTTVQLAPCDSSHSTIPKRTVPPGRDLCPCDGCGTKVDVEEGLICDECDTMYHFACVKLLNPDIKQVPAIWHCSTCSFKKKELAADTTNNVAHDCLHGGNCVLCDQLELVKTEEEDPKLPIKIELAEEREGSSVSSMGEDNEPDLSTTALSNLCKHCGTCEDDDKRFMVCGHPYCVYKFYHIRCLKTSQLAIEQQKKLGCWYCPSCLCRGCFQDKDDDQIVMCDGCDEGYHIYCMRPARNTIPKGKWYCTFCKIRRAAEGMHKYEDSVLKIHGNSKHACNVNQSKDSEGDGTEK", "function": "Probable transcription factor involved in the regulation of floral induction under long day (LD) conditions. Promotes photoperiodic flowering by repressing GHD7, a major floral repressor. Seems to function independently of HD1.", "AFDB_id": "AF-Q6ZJM9-F1-model_v4" }, { "swissprot_id": "Q4P257", "sequence": "MVAIPRVAAARSLARQLARQSLRTTSFASAPVRIAIASTPLARSPSSFRSLSSSTRRSAAAAAAAAAAKATPAHDDSHTPMAVLTEADLGRLVRQRNVGISAHIDSGKTTLTERVLFYTGRIKDIHEVRGRDAVGAKMDHMELEREKGITIQSAATYCSWKATPPTEKASVSGDAANVESKELMEKKQDFHINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVSGVQSQTITVDRQMRRYSVPRISFINKMDRAGANPWRVIGQIRNKLKMPAAAVQIPIGAEDDFNGVIDLIRWKAVYNEGHKGIDIRETDEIPAEYLELAKQKRAELIEQLAEVDDEMTEMFIEEREPTIEELAAAIRRTTIRCQFSPVFLGSAIKNKGVQAMLDGVCSYLPNPAEVPATAMDMSSAATKKAAEEAAQAAGEDQEAAAEARKNAAPPVLPLSPASEAPLVGLAFKLEEGKYGQLTYMRVYQGTLKRGNLIFNARTGKKVKVPRLVRMHSNDMEDVDEIGAGEICAMFGVECSSGDTFTDGTTQLSMTSMFVPEPVISLAITPEGKESQNFSRALNRFQKEDPTFRVHVDKESNETIISGMGELHLEIYVERMRREYNVPCTTGKPRVAFRETIEKKATFAYTHKKQTGGAGQFGRVMGYIEPMEVDPETGVDTAFDNRVVGGSIPNGYISACEKGFYDALEKGALSGHAVTGVRFVLEDGAAHSVDSSELAFRLATAGAFREAYQKANPVILEPKMTVEVVAPIEFQGAVIGALNQRKGTISDTEVREDEFTLTAEVSLNDMFGYSSQLRGLTQGKGEFSMEYKCHTPVMMNIQKEMHEAYRKKQTEKK", "function": "Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.", "AFDB_id": "AF-Q4P257-F1-model_v4" }, { "swissprot_id": "P40967", "sequence": "MDLVLKRCLLHLAVIGALLAVGATKVPRNQDWLGVSRQLRTKAWNRQLYPEWTEAQRLDCWRGGQVSLKVSNDGPTLIGANASFSIALNFPGSQKVLPDGQVIWVNNTIINGSQVWGGQPVYPQETDDACIFPDGGPCPSGSWSQKRSFVYVWKTWGQYWQVLGGPVSGLSIGTGRAMLGTHTMEVTVYHRRGSRSYVPLAHSSSAFTITDQVPFSVSVSQLRALDGGNKHFLRNQPLTFALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLTSCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTTEVISTAPVQMPTAESTGMTPEKVPVSEVMGTTLAEMSTPEATGMTPAEVSIVVLSGTTAAQVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDGTATLRLVKRQVPLDCVLYRYGSFSVTLDIVQGIESAEILQAVPSGEGDAFELTVSCQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKGGSGTYCLNVSLADTNSLAVVSTQLIMPGQEAGLGQVPLIVGILLVLMAVVLASLIYRRRLMKQDFSVPQLPHSSSHWLRLPRIFCSCPIGENSPLLSGQQV", "function": "Represents a potent melanoma-specific antigen. Among melanoma non-mutated self-peptides, G9-154 (KTWGQYWQV), G9-209 (ITDQVPFSV) and G9-280 (YLEPGPVTA), appear to act as immunodominant common epitopes that stimulate anti-tumor immune response mediated by HLA-A-restricted cytotoxic T cells.", "AFDB_id": "AF-P40967-F1-model_v4" }, { "swissprot_id": "P44788", "sequence": "MKKFSSKTIKAKNSVKMTALSTRAIAANLILQVLDEGKSLSALIPEVQLSVKAQDLPLLQEICFGVCRVLPRLEQIIKRLVDKPLKGKTRIVHCLLLVGLYQLLYMRVPAHAAVDEVVNATKSLKSDSFRGLVNAVLRRFLREQDEILAIIDKNWQTLHPEWFVNKLKKAYPNWREIIEANNQKPPMWLRVNSQKNALETYRTLLEEQGVSSKTSHHPNALCLDIPIAVQKLPHFEEGAVTVQDLSAQWAATLLEPKNEEWILDACAAPGGKTTHILELAPQANVIALDVESHRLKRVEENLERLNQQAIVVCGDASKPDEWLAEIGKSAAKFDRILLDAPCSATGVIRRHPDIKWLRKETDIAQLVELQKKILSALWEKLKPNGVLLYATCSVLPEENCEQIQAFLNAHADAELLSLPFSDDKSAVGFQFIPQPNSGDGFYYAKLLKRAS", "function": "Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.", "AFDB_id": "AF-P44788-F1-model_v4" }, { "swissprot_id": "P13130", "sequence": "MKFTSVLAFFLATLTASATPLYKRQNVTSGGGTVPVIITGGPAVSGSQSNVTTTTLFNSTSTLNITQLYQIATQVNQTLQSESSSGIIIVTNWRSIETLSFFCSIVFNTSKTIVITENFLWGVPILSSSDAEGRGTLVAGRDKVVYSGVFPPYTVPVGVLSGQKNVQWFFDACEPTLIASNSTIRTQYSNFTSAQISSNASSGTNTSSSSSSPLVPIIYEEGYSQSLIQSLSSSIQGLVVVSSGTSHNSTVASWTSVDFPVVYASDGSSGHDGSGIGFISNTSIPQGAISAGYLSPIQAQTLLSIAIHNQVTSSSELQQIFPVSQQ", "function": "Serves a protective function during the early stages of spore wall formation, and contributes to spore wall maturation.", "AFDB_id": "AF-P13130-F1-model_v4" }, { "swissprot_id": "Q61045", "sequence": "MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPTFSYTSSSTPTISDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPERPGSQHELSCAYRQFPDRSSLCYGFALDHSRLVEDRHFHTQACEGGRCEAGRYFLGAPPTGRDPWWGSRAALPLTKASPESREAYENSMPHITSIHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQNSPHEPSKIETLIRATQQMIKEEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQPPPTGEVCHSSALASTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPSSDRITKSSLILAKDYLHSDMSPHQTAGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS", "function": "Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.", "AFDB_id": "AF-Q61045-F1-model_v4" }, { "swissprot_id": "A6SU94", "sequence": "MHGSTGFVQGTRPAGDQADPLPVVRVSSESMTRYALYFTPVDDSPWAQAGSSWLGRHPASPEPVQQVNIPGIPRILLSSLTADARRYGFHATLKAPFRLFEGFNEEHLLQMARAFCAAQKAIVLDEVRVRPLMDFLALQVNGPLDEIGGLAMRCVTYFDLLRAPLTEPELAKRRRAGLNARQSALLQRWGYPYTEEFYRFHMTLTDALMHADADVIFTIRKAAEQHFAAAVAAVPLAIDALTIAREEYPGAPFVEWQRIPFSGQGERASLPHSGRIFFCVGPSGVGKDSLLNWVREHSAGDEKLVFAQRTITRATQANEAHEAVDTASFWRLAAGGQFAMVWQANDLCYGIRRGIEADLKAGRDVVINGSRAYVPQLLQAFPDAIVIWIDASENLLRERLEARQREQGPALLKRLKRAKEFAPSEQAQVIRLDNSGALEAGGQKLLDILRQAK", "function": "Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).", "AFDB_id": "AF-A6SU94-F1-model_v4" }, { "swissprot_id": "I1WSZ3", "sequence": "MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHLANVANVDDIPRKSDLWIDQLHGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPASAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHALLRAYAYTVVVIEVLAVVLTAALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESFVRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDMLFLARSDNAQSHLAIRTLDAAAQAERVAGYYEPMAEDAEVSIVVRGKAEVRADALLYHRALSNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIEAPHRERIFERFYRVDPARHNSASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA", "function": "Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates IrlR by phosphorylation.", "AFDB_id": "AF-I1WSZ3-F1-model_v4" }, { "swissprot_id": "Q52329", "sequence": "MNATNTDVFAQVGGLEARGAKMKKRGTRFLIAALAVLAIAGIGAVTGWAISPSATPGSIDVPQVLASTFSDQVPGSEGGGLGGGLPFTSAVGAFTDFMAGPAIFTLGILGIVVAGAVLVFGGEFSGFVRSVCMMVIAVSMIFVSSNLVKGILGGDHDAGPAEPSPRARFMAAVEAKDFARVQELIEARGAKSAADYVLAQLAVAEGLDRKPGARVVVGKAAGSMAMPPAALGFTPRGEAAYAIERSAYGEPRSSIAKQYQQEWNRKAATWWAMAGVAGIIGAILAAAATGFVGLAVSIRNRVKRVRDLLVMEPGAEP", "function": "Belongs to the kla operon, which is associated with cryptic tellurite resistance, and IncW plasmid fertility inhibition.", "AFDB_id": "AF-Q52329-F1-model_v4" }, { "swissprot_id": "Q7ZVC2", "sequence": "MSFRDLRNFTEMMRALGYPRLISMENFRSPNFPLVAEILIWLVKRYEPQMEIPSDVDTESDRVFFIKAVAQFMATKAHVKLNLKRLYQADGYAVKEMLKITSILYNAMKTKENAGGDQNNDENSKFKFDLGSKIADLKLARQLGSEITAKGAALFDLLGQEEDLRESRTAAIARPLEITETERAMRAAVKDVTESIQMTKDLLNNVSSDEASLEAKIEKKKQDLERNQKRLQTLQSVRPAFMDEYEKIEEDLEKQYQTYVEKYRNLSFLEQQLDDYHRVEQERFEEAEMAMKMRQNKLKEEEKRLMRSGVARDEDSDVDIPEDEGSDSDIDDGQQARPHHPRHTQISGRGGARFIGSMRGGDSEETEDSEIDVDDDDEDDDEDGEEDEEENEDLDEDNDSLEGSSGKPGRTNQSLHPQILEESDNDF", "function": "Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B).", "AFDB_id": "AF-Q7ZVC2-F1-model_v4" }, { "swissprot_id": "Q8R5K4", "sequence": "MPSAGERPAVKMGPAPAGEQHRRATEDPEVMELAFEGMDKEKAPSRKRARTEPPAEGLLQPVNLSREELYKEPTNEELNRLRETEILFHSTLLRLQVEELLKEVRLSEKKKERIDNFLKEVTKRIQKVPPVPEAELTDQSWLPAGVRVPLHQVPYAVKGSFRFRPPSQITVVGSYLLDTCMRPDINVDVAVTMPREILQDKDGLNQRYFRKRALYLAHLAYHLAQDPLFSSVRFSYMSGCHLKPSLLLRPHGKDERLVTVRLLPCPPLDFFRPCRLLPTKNNVRSAWYRGQSCPDYEPPTPHYNTWILQDVALETHMHLLASVLGSAQGLKDGVALLKVWLRQRELDKGLGGFNGFIISMLVAFLVSKRKIHTTMSGYQVLRSVLQFLATTDLTINGISFSLSSDPSLPTLAEFHQLFAVVFVDPSGRLNLCADVTASTYNQVQYEAELSMALLDSKADDGFQLLLMTPKPMIQAFDHVVHLHPLSRLQASCHQLKLWPELQDNGGDYVSAALGPLTNILVQGLGCRLHLLAHSRPPVPEWSINQDPPKHKDAGTLTLGFLFRPEGLTSVIDLGPEADKPEAADFRQFWGTRSELRRFQDGAIREAVVWEAESLFEKRLIPHQVVTHLLALHADIPDTCIQYVGGFLDALIQNPKEISSTGEEALALAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPAPVRPAYSFYNRLQELASLLPRPDKPCPAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAEVLTQEHRLQCCATATHTDVLKDGFVFRIRVAYQREPQILKEVRSPEGMVSLRDTPASLRLERDTKLLPLLTSALHGLQQQYPAYSGVARLAKRWVRAQLLGEGFTDESLDLLAASLFLHPEPFTPPSVPQVGFLRFLYLVSTFDWKNNPLIVNLNGELTAEEQVGIRSSFLAARTQLPVMVIITPQDRRSSVWTQDGPSAQILQQLVSLAAEALPILEKQLMDPRGPGDIRTVFRPPFDMYDVLIHLTPRHIPRHRQAVDPPVASFCRGLLAEPGPSSLMPVLGYDPPQLYLAQLREAFEDLALFFYDQHGGEVIGVLWKPSSFQPQPFKASSIKGRMVVSQGGELVMLPNIEAILEDFAVLGEGLVQAVEARSERWTV", "function": "Probably associated with rRNA.", "AFDB_id": "AF-Q8R5K4-F1-model_v4" }, { "swissprot_id": "P30283", "sequence": "MGENHDHEQSIKRNSMIYNENERQLCNSNLKILQNKRALSKNDSSSKQQVQDSKPRRALTDVPVNNNPLSQNKRIVAGSKAAKVRREENIRPIVSAVQKRQIYNDRTAAEQEEEEEEEGEDDDAASIVNKKRRIDAEGVSEIVGWQDLDYVEKDDTAMVAEYSAEIFAFLYRRELETLPSHNYLLDKTSKYYLRPSMRTILVDWLVEVHEKFQCYPETLFLSINLMDRFLAKNKVTMNKLQLLAVTSLFIAAKFEEVNLPKLAEYAYITDGAASKNDIKNAEMFMLTSLEFNIGWPNPLNFLRRISKADDYDPVNRNIGKFILEYAYCCHQFIHLPPSTVSAMAMYIARRMTNRNKNELWNGTLQHYSGGIDPIHDEAFQSLCIDLVKDIASSKTHLDSLILKYKKPRYGSVYFQTFKWCTSEMHSNFQNLFNLK", "function": "Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28.", "AFDB_id": "AF-P30283-F1-model_v4" }, { "swissprot_id": "Q01371", "sequence": "MNNNYYGSPLSPEELQHQMHQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQHQQQQKTNQHRNAGMMNTPPTTNQGNSTIHASDVTMSGGSDSLDEIIQQNLDEMHRRRSVPQPYGGQTRRLSMFDYANPNDGFSDYQLDNMSGNYGDMTGGMGMSGHSSPYAGQNIMAMSDHSGGYSHMSPNVMGNMMTYPNLNMYHSPPIENPYSSAGLDTIRTDFSMDMNMDSGSVSAASVHPTPGLNKQDDEMMTMEQGFGGGDDANASHQAQQNMGGLTPAMTPAMTPAMTPGVSNFAQGMATPVSQDAASTPATTFQSPSLSATTQTIRIGPPPPPSVTNAPTPAPFTSTPSGGGASQTKSIYSKSGFDMLRALWYVASRKDPKLKLGAVDMSCAFVVCDVTLNDCPIIYVSDNFQNLTGYSRHEIVGRNCRFLQAPDGNVEAGTKREFVENNAVYTLKKTIAEGQEIQQSLINYRKGGKPFLNLLTMIPIPWDTEEIRYFIGFQIDLVECPDAIIGQEGNGPMQVNYTHSDIGQYIWTPPTQKQLEPADGQTLGVDDVSTLLQQCNSKGVASDWHKQSWDKMLLENADDVVHVLSLKGLFLYLSPACKKVLEYDASDLVGTSLSSICHPSDIVPVTRELKEAQQHTPVNIVFRIRRKNSGYTWFESHGTLFNEQGKGRKCIILVGRKRPVFALHRKDLELNGGIGDSEIWTKVSTSGMFLFVSSNVRSLLDLLPENLQGTSMQDLMRKESRAEFGRTIEKARKGKIASCKHEVQNKRGQVLQAYTTFYPGDGGEGQRPTFLLAQTKLLKASSRTLAPATVTVKNMSPGGVPLSPMKGIQTDSDSNTLMGGMSKSGSSDSTGAMVSARSSAGPGQDAALDADNIFDELKTTRCTSWQYELRQMEKVNRMLAEELAQLLSNKKKRKRRKGGGNMVRDCANCHTRNTPEWRRGPSGNRDLCNSCGLRWAKQTGRVSPRTSSRGGNGDSMSKKSNSPSHSSPLHREVGNDSPSTTTATKNSPSLRGSSTTAPGTITTDSGPAVASSASGTGSTTIATSANSAASTVNALGPPATGPSGGSPAQHLPPHLQGTHLNAQAMQRVHQHKQHQQHQQQHQQQHQQQHQQQHQQLQQHQFNPPQSQPLLEGGSGFRGSGMEMTSIREEMGEHQQGLSV", "function": "May function as a transcription factor involved in light regulation. Binds and affects blue light regulation of the al-3 gene. Wc-1 and wc-2 proteins interact via homologous PAS domains, bind to promoters of light regulated genes such as frq, and activate transcription.", "AFDB_id": "AF-Q01371-F1-model_v4" }, { "swissprot_id": "F4JTN2", "sequence": "MDILKSYHLLAAAYSAPAWASFMAGAFLVLTLSLSLFLVFDHLSTYKNPEEQKFLIGVILMVPCYSIESFASLVKPSISVDCGILRDCYESFAMYCFGRYLVACIGGEERTIEFMERQGRKSFKTPLLDHKDEKGIIKHPFPMNLFLKPWRLSPWFYQVVKFGIVQYMIIKSLTALTALILEAFGVYCEGEFKWGCGYPYLAVVLNFSQSWALYCLVQFYGATKDELAHIQPLAKFLTFKSIVFLTWWQGVAIALLSSLGLFKSSIAQSLQLKTSVQDFIICIEMGIASVVHLYVFPAKPYGLMGDRFTGSVSVLGDYASVDCPIDPDEIRDSERPTKVRLPHPDVDIRSGMTIKESMRDVFVGGGEYIVKDVRFTVTQAVEPMEKSITKFNEKLHKISQNIKKHDKEKRRVKDDSCMSSSPSRRVIRGIDDPLLNGSFSDSGVTRTKKHRRKSGYTSAESGGESSSDQAYGGFEVRGRRWITKD", "function": "Required for programmed cell death (PCD) associated with hypersensitive response (HR). Involved both in the induction of EDS1/PAD4 mediated HR and in accelerated cell death in the acd11 mutant. Not required for HR induction elicited through pathways exclusively dependent on CC-NB-LRR resistance proteins.", "AFDB_id": "AF-F4JTN2-F1-model_v4" }, { "swissprot_id": "P91863", "sequence": "MKLIFLLLLFGVSPIVCQDFEDGVFLAKITSIDEHDARKIGRRFGFEAQWKLQSYTDVYVGRRLRRRKRGIEDEIVAEMMLSQQVQFIEKLQGFRRYKRAPMTNKGYPVHVWNLTPSLYIREAWEDGFNASRVTVAVVDDGVDIKHVDLKSAFSPRVSFDFVRFGDLPTPKNSKEFEHGTQCAGLVAMEGQQCGLGVGHGATLGAIKLLGQDFLNDALEGDALAFQKDLIDIYSVSWGPKDDGKSAEKPAKFTEEAIKNGALHGRNGKGNIFVWASGNGGVNGDNCAYDGYVSNEYTLSFGVIDASGAPAAYGEGCSSVLAAVSGGDAMIQTTGLESTCSSISGSSASAAIASGIISLVLDANPTLSQRDIQHLIARTSNASAIRDVELYENSAGLNFHPKVGFGLLNAQKLVVMAATWENVAPQVTCEKMNLANGIIDNSDCDVTKVERVIVSGSIIHPHRGQVQIRLESPRGTISELLPLRPKDTSRDLLDWNFVSVNFFGENSRGIWKLHVTSEEDDVDFRVEMKMFKVVGTMS", "function": "Probable serine endoprotease which cleaves preproteins at paired basic amino acids. May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, required for fatty acid uptake by intestinal cells and therefore regulates the levels of triglycerides in the intestine. Plays a role in locomotion.", "AFDB_id": "AF-P91863-F1-model_v4" }, { "swissprot_id": "A4RM69", "sequence": "MPPPPHQKPENVLKRAHELIGVNQAPAALTLLHEHITSKRSRNVPIASLEPVMVLLVELSVEQKKGKLAKDALYQYKNIAQNTNVGTIELVLKKFIELAAGKVTAAQQKADEVQSSIEATNSTSVDDLEATETPESILLATVSGEQSRDRTDRAIVTPWLKFLWEAYRTVLDILRNNARLELLYQSTAMQAFEFCLKYIRKTEFRRLCELLRNHVQTAAKYSTQMHAINLNDPDTLQRHLETRFQQLNVAVELELWQEAFRSVEDIHTLLNLSKRPPKNIMMANYYEKLTRIFLVGENYLFHAAAWSRYYSLLRQSAAVVASGQGKKADNPPATPADLQKAASFVLLSALSIPVISTTRSRGAMVDFDEAKKNKNSRLTHLLNMSQAPTRAVLFKDAMSKSLLNQARPEIRDLYNILEVDFHPLSICKKISPILAQIGADEDMKKYVLPLQQVILTRLFQQLSQVYETVDLEFVESLAQFPEPFQVTRATVEKFIMNGNKKGDLSIRMDHGTGVLSFDTDIFSSSKASHSGSAAGSAEAEGGSVQRLQRTPSEIVRSQLVRLGRALYTTCYYVDPSFNESRVKAREAALARAKAGAEKEHREILARKDIIQKRKEEASDLQAKREKENAKIKRMREQALLEAEQQRLAEEQKERERKRKEKEMQEIRKQEAESLIKDLKIGPNALDVSAEDLANLDTSQIRAIKVAQLEREKNDINEKLRITGKRLDHLERAYRKEEVKKLHEDYESQKKRDLDAYSKIKEETLKESKIKHEESVELKHRLSRLMPFYEEFRANLQERRRDEFEKRRRDAERELEKQIAQRKKEYREKKLREKRQREEEERQLREAEERAAKEKEEQKRREEARKEELARAKAQREAERQEMAEKAALQARREEEALERRKREKEKLASAPPASAAPVRASESAGGPPRLNLAGAGGKPSWRDRVPSSNVGAAPSERSERPSERPAPARTGTPMERTDSNDRAGGPPRLNLARADGAKPSWREREQAKASGGPERDLPPSRAASGRGPPMHRTDSGRGENGRDESPAPPRDSLTASGAPGKYVPRWKRENAGN", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.", "AFDB_id": "AF-A4RM69-F1-model_v4" }, { "swissprot_id": "A6TJD3", "sequence": "MKIIVFGITHKKATIDLREKVAFSQSKKQEAYSLLKESPFIHEAVILSTCNRSEVFAVVQDTSIARRWFKRFYTDFFQLKETALEGCNHFEKGREAVQYLYHVCVGVDSLVIGEDQILGQVKEAHAEALDFAATGKILNKLFLEAVTTAKEVKTETAISENALSISSIAVKQMENHLKGLVGKTVLVVGFGKMSRIAIENLLCKGIKRLYICNRTKESVQELIEKHPQIHYLSYDQKYEMLNGVDAVISATGAPHFIFYKEDMEKIYQKHRPMCMIDIALPRDIDPAVKEIEGIELFHIDDLKEIANENLAYRMDCIEIIKQSINEAIEKYEGWYQCLPIYPRIQAIKAYSETLTDQELEKLFKRLDHMAEEDRQVIEVVVKSLVKKMWKTPILQLKDAGIRGNGEAFAAFVDEFLGLDAGCGK", "function": "Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).", "AFDB_id": "AF-A6TJD3-F1-model_v4" }, { "swissprot_id": "Q960V3", "sequence": "MTHVNNGEVMEKEMEPTGERERDRETAAGSGVHHRFLASASERDANSGNALEAAATKTKTGTTITNLEDLAFEACQNWSDLHQDFFITDDELEYEDELSLGSSIGGNIATTTTADAAVEGLITGEHQNEQLLMEVLCGNRVSQMTRAYDDIEAVTRLLEEKEKDLELTVQIGKELLTQNNALEARVADLETDLKASNDDRAQLVHELHKKNELISVLTNDADDGTDTDTPTMSKSITLDLLQRKVNSLLDENKSLKCEATQLAHQTDEVEEHERQLMADISAQLNDANSQYDNLSLELERQREENRLQHEQIVNLTARLAEAEMRLHQLTQDNDEHLSLLHVTKENQNALALELVEFKQRYEEVLALLHSAQDQLKQQRKRSQPQARSSFLGGLGTSGAGMGGSLFPPDSLHCELMESSLYSENSLDSGISGDSQRSADRISRMMMHMPSGGMSSSTMGGSVYAGAGNVPPYKRVFDTVRCAGKSGNYMDSGNVSMTQLGAMSMSSSSGPRMASMAYPAGSYYRGGSNQSLGVKTLSSESLNSQSDDGYPAQPSGVPGAPGAKELEAALKRLTPAEVLARRAMLSYAPAGTYNYDEPMGHGTGNVRNSDLPLGVRTPDSIMSTGSSGMSGSTNHMSASMTHQWRLPEKLQIIKPMEGSQTLHHWSRLATPTLSGLLDERPGVTIRGGRGLDDLGMQIYTLSDVEEDVSDDLPGKQFEAPGCTFTYTNSMVMHPDDGFVNDLSFLSQSQMSSRMASTSTSRQPSCPATPRAGLSRKNSCSTFSVNLGLAGMLNERGIKAVTPSALNTPAGPNFSPTVTPCNSPEGSPPRAQSPEPLFGLLSCGADLIRRKIVGDQHQQQQQKQRSSLSKQQQQKIMLSHLERRALRSLNLIEKVESIGLENIISAQRGLGSGIANRSSSPLSSGSLQSLHTSSNSIVDDIHFDRAQIKGVLHRGLKSPTPATASTSAAAAASGPGISTSSSTSAYNSDDSDDQGLVMKIKPSKSATPTTTGAAQSQPSSATTSNGTASETRLKQMQRQKSRRQLKNGMANQRPDLGTISGAGGGGRVRPDLGKVADSGSSSKLSTKRSEAKPAEEEEATPQTITQAFVGSVSSLLFGRKGGWL", "function": "Required for kinesin-mediated axonal transport of mitochondria to nerve terminals. The oocyte acquires the majority of its mitochondria by competitive bidirectional transport along microtubules mediated by the Milton adapter. Mitochondria enter the young oocyte en mass from interconnected germ cells to generate the large aggregate known as the Balbiani body. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria.", "AFDB_id": "AF-Q960V3-F1-model_v4" }, { "swissprot_id": "D7B2S5", "sequence": "MTENARTTPEAVRTVACVGAGVIGGGWVAHFLGRGYRVVAWDPAPDAESRLRGLVSSAWPALEELGPAEGASMANLRVVDTLAEAVADADFVQESAPERLDLKIDLLAEIDAATPEGVVIASSTSGYSMSEMQVGARTPGRLVVGHPFNPPYLVPLVEVVGGERSERWAVDWASDFYRAAGKSVITMERELPGFIGNRIQEAAWREALHMVAEGEATVEQIDLAMTSGPGLRWAFFGPCLTFHLAGGEGGMAHMLDHFGPSLKSPWTRLEAPELTAGLRDRMVAGTDEVVAGRSTAELIAQRDRRLIAVARALEEVERAEAAERAGADA", "function": "Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.", "AFDB_id": "AF-D7B2S5-F1-model_v4" }, { "swissprot_id": "Q8PTD1", "sequence": "MCMRRFYICSQGDNLAIKRIGIASRCDRPEVLDMVREILARFSSQVQIFVSTATAEVLGIEGTPVERMRDEGVELVISVGGDGTVLRNIAKMKDPLPILGINMGTLGFLVDVEPEDAIETIEEVLYGFSYLERMRVDVFLNGEMLETATNEIAVMSAKPAKIIQFEVHVNDCLLDEMRADGVVFATPTGSTAYAMSAGGPIINPRVNAIVVVPVAPFKLSSRPWVIPADSEITVKLLEHKKDAVIAIDGQKSYRIRPEDIVKLKKSKFPARFVRISDTCFYERVQRKLS", "function": "Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.", "AFDB_id": "AF-Q8PTD1-F1-model_v4" }, { "swissprot_id": "P12364", "sequence": "MKKETIFSEVETANSKQLAVLKANFPQCFDKNGAFIQEKLLEIIRASEVELSKESYSLNWLGKSYARLLANLPPKTLLAEDKTHNQQEENKNSQHLLIKGDNLEVLKHMVNAYAEKVKMIYIDPPYNTGKDGFVYNDDRKFTPEQLSELAGIDLDEAKRILEFTTKGSSSHSAWLTFIYPRLYIARELMREDGTIFISIDHNEFSQLKLVCDEIFGEQNHVGDLVWKNATDNNPSNIAVEHEYIIVYTKNKEQLISEWKSNISDVKNLLVNIGEEFASKYTGNELQEKYTQWFREHRSELWPLDRYKYIDKDGIYTGSQSVHNPGKEGYRYDIIHPKTKKPCKQPLMGYRFPLDTMDRLLSEEKIIFGDDENKIIELKVYAKDYKQKLSSVIHLDGRVATNELKELFPEMTQPFTNAKTIKLVEDLISFACDGEGIVLDFFAGSGTTAHTVFNLNNKNKTSYQFITVQLDEPTKDKSDAMKHGYNTIFDLTKERLIRASKKNRDQGFKVYQLMPDFRAKDESELTLSNHTFFDDVVLTPEQYDTLLTTWCLYDGSLLTTPIEDVDLGGYKAHLCDGRLYLIAPNFTSEALKALLQKVDSDKDFAPNKVVFYGSNFESAKQMELNEALKSYANKKSIELDLVVRN", "function": "A beta subtype methylase that binds the system-specific DNA recognition site 5'-CAGCAG-3' and methylates A-5 (of only 1 strand as the other does not have an A residue). DNA restriction requires both the Res and Mod subunits. The A-5 nucleotide flips into the catalytic pocket of one Mod subunit for modification, while the other Mod subunit makes most of the DNA sequence-specific contacts.", "AFDB_id": "AF-P12364-F1-model_v4" }, { "swissprot_id": "W7MS18", "sequence": "MAGDFSNRAPWKRSACDRCRAQKLRCHRDSGHSTDACLRCLKSGIECVTSKARPTGRPPSRQVQPTVVVEQGDTSSSSHTTDSSPSAGGTDMSNMMNFEYDLSLDNILDSIGMQHSDFMVNDNILVDISPLSSSQSTGQHSVTQAQVQAQTVDPSTIQSTASYQFNSLPSTSSMDSALPIRSDHVELLLSRLHSKLSAQLYSIRSSPWDIKGTLNLSLAHQGIGQDFENCESHPLVQVSQACTELERLLSGLRVPASAEHTPSSFSYTPAVPPRLRTTQLLIALSCYIQIVSIYGIIFSKVFDYLLSTSKTSNGSYQSSPLTLYIGGLPIPPNETLSGNLLVHLIEHQLHQIEQLMGLPEHYRVSSRAKDTKDGELGLFGSQHSQSLLNAAIQLGEDRDGNHDDIRCVRALKVVMRQIKDF", "function": "Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties.", "AFDB_id": "AF-W7MS18-F1-model_v4" }, { "swissprot_id": "Q9ZRV4", "sequence": "MIDDSSLTAEMEEEESPATTIVPREPPKIQRLEESVVNRIAAGEVIQRPVSAVKELVENSLDADSSSISVVVKDGGLKLIQVSDDGHGIRREDLPILCERHTTSKLTKFEDLFSLSSMGFRGEALASMTYVAHVTVTTITKGQIHGYRVSYRDGVMEHEPKACAAVKGTQIMVENLFYNMIARRKTLQNSADDYGKIVDLLSRMAIHYNNVSFSCRKHGAVKADVHSVVSPSRLDSIRSVYGVSVAKNLMKVEVSSCDSSGCTFDMEGFISNSNYVAKKTILVLFINDRLVECSALKRAIEIVYAATLPKASKPFVYMSINLPREHVDINIHPTKKEVSLLNQEIIIEMIQSEVEVKLRNANDTRTFQEQKVEYIQSTLTSQKSDSPVSQKPSGQKTQKVPVNKMVRTDSSDPAGRLHAFLQPKPQSLPDKVSSLSVVRSSVRQRRNPKETADLSSVQELIAGVDSCCHPGMLETVRNCTYVGMADDVFALVQYNTHLYLANVVNLSKELMYQQTLRRFAHFNAIQLSDPAPLSELILLALKEEDLDPGNDTKDDLKERIAEMNTELLKEKAEMLEEYFSVHIDSSANLSRLPVILDQYTPDMDRVPEFLLCLGNDVEWEDEKSCFQGVSAAIGNFYAMHPPLLPNPSGDGIQFYSKRGESSQEKSDLEGNVDMEDNLDQDLLSDAENAWAQREWSIQHVLFPSMRLFLKPPASMASNGTFVKVASLEKLYKIFERC", "function": "Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.", "AFDB_id": "AF-Q9ZRV4-F1-model_v4" }, { "swissprot_id": "P43494", "sequence": "MSIVIIGSGQAGFEAAVSLRSHGFSGTITLVGDEPGVPYQRPPLSKAYLHSDPDRESLALRPAQYFDDHRITLTCGKPVVRIDRDAQRVELIDATAIEYDHLILATGARNRLLPVPGANLPGVHYLRTAGEAESLTSSMASCSSLVVIGAGFIGLEVAAAARKKGLDVTVVEAMDRPMARALSSVMSGYFSTAHTEHGVHMRLSTGVKTINAADGRAAGVTTNSGDVIHADAVVVGIGVVPNIELAALTGLPVDNGIVVDEYLRTPDENISAIGDCAAYPIPGKAGLVRLESVQNAVDQARCLAAQLTGTSTHYRSVPWFWSEQYESKLQMAGLTAGADTHVVRGSVDSGVFSIFCFLGTRLLGVESVNKPRDHMAARKILATEMPLTPEQAADTDFDLKLAIARHKDTHKDEVASADIGERQVVAS", "function": "The degradation of the thiocarbamate herbicide EPTC by cytochrome CYP116 (thcB) requires the participation of a flavoprotein, rhodocoxin reductase, and an iron-sulfur protein, rhodocoxin, to mediate the transfer of electrons from NADH to P450 for oxygen activation.", "AFDB_id": "AF-P43494-F1-model_v4" }, { "swissprot_id": "A1ANJ7", "sequence": "MKRESSTQLRAGFTTGTCAAAAAKGAALMLRDQCLCDQVTLRLPTGISATFRLEGQEFSSSSASCFVVKDAGDDPDITNGAELHARVTVPPPLPLAQGDMVEITGGTGIGRATKPGLAVAPGEWAINPVPRRMIQEAVGEVFADRRVLVQISIPDGELRAQKTLNARLGILGGLSILGTTGIVRPISAKAWTDTIDTALDVARACGCATVVFSTGRTSELAAQEWLKVRGARFDFGDQESGNADREPGTMYLEPLPEEAFVMMGDHVAHALRSARERGFHQPVIACQYAKLVKIACGYENTHAAASDMDLARLRAWAVEAELPSRVVETIASANTAREIAVSTGFDPALLTLTARKALQASQGHATGAHPLFVVADYGGRIVFHSLPAENNA", "function": "Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.", "AFDB_id": "AF-A1ANJ7-F1-model_v4" }, { "swissprot_id": "Q3E8L0", "sequence": "MSLHRDSMVPVNSRLENMDSPILSKICAWGVMLGLFALSLFAMAYACYHKQTSNSCIEEKQGKKQVLKPLDMEPKIVVIMAGNENPTFFAKPTQINA", "function": "Probable subunit of an amino acid transporter involved in the regulation of the amino acid metabolism. Stimulates amino acid export by activating nonselective amino acid facilitators.", "AFDB_id": "AF-Q3E8L0-F1-model_v4" }, { "swissprot_id": "Q10579", "sequence": "MRFCNSKLTSIDNRCDVAIISKDEERFEVKLVESEIARELNRLGALSPRSMQKNILVPFTTQTVKYLLGLEKVSDSTDEMGWFGIEKSLEEIAGFGQHCFPKILEMKNTICDHILSTLSDVNCFLLHKKFREFDCQNHAHKTLEYILYNLARMVVVDKRVDVEFYRLPVEEVKHLLSSEEVNVEQETQIIEVINQWIAADFENRDKFRPMLMSTVRFLALDQQIAKSLSQFHPSLKPARRTRDVLIIIGGWLHRQACDRIEWFDPENNCWKVSQQKLPTTLAYHGSAIVDGILYLFGGSTGQRTRCETWKLSTETWQWDRCNNMMEPRNYISNSSVVYDGRIYVFGGQNFREITRTAVRSRTGEVFDPKTNKWTETASLSDMRSDCAAEVFENQIYVSGGFNGDMILASVEVYNPIGNVFSRTVDLPYPITGHCLLNHGNQLLIVGGFDGAERQNKIWMWHRTGEWQQRPEKLIYGRSTSAACSYKGWLFSVAGYTEKVEATCEILLPEPNASRFSFIPDVPRAKSALNVLVAPNWRNFLERRGTINEQSMEMDDDYEDDAGASYMSINN", "function": "May play a role in the spermatocyte cytoskeleton, possibly interacting with actin.", "AFDB_id": "AF-Q10579-F1-model_v4" }, { "swissprot_id": "P31912", "sequence": "MNDAGMGRFEGSYLGDRGRLAADARLECKICWWEYDPEVGDPVWQIAPGTSFSALPAHWRCPNCDGEAEQFMVLGPQA", "function": "Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. Could be involved in hydrogenase-linked redox processes.", "AFDB_id": "AF-P31912-F1-model_v4" }, { "swissprot_id": "P94273", "sequence": "MGQKVHPYSLRVKINKDWKSKWYFDKKLYSAILHEDFLIRREIMKFLKGIKFDISDIEIIRNNPQKVTVVIVTPRPGSVIGLKGSNLEKIGQLLTKKISKKISIKIKEVKRPELDAQIIANGIAKQVENRASYRKVLKSSLSTSMLKGAQGLKIKIAGRLGGAEIARSFEVKEGRVPLHTLRANIDYGFSEAQTTYGIIGVKVWLFKGEVLGRQTNSDAGQVINKKPFRERGDAVKNFDKTLNNREKANEKQTRLLDKKDGLSKDEVDLLNKKKFSASFSKERDDSNEQDIGG", "function": "Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.", "AFDB_id": "AF-P94273-F1-model_v4" }, { "swissprot_id": "G2TRT1", "sequence": "MHLSKASFLFDCSRFILNFHERCLKNGVRTKKACVICRSKKQKCDGQLPCLYCKKYEYQCAYEGQATSTCNSEASLFNDANFKIGSDYRSKRIKVVSDTNNNKEDGDGKLSFTQCNPRMDIHHEAENFTAMVPYYEPKKFRFFYENSAIVFPRIYVFIYFEEVHPIFSMFDQKAMEKKIQFLWDNKSTDSCSEYVVISVKGKLVEHITQVLESSLSTTILSSIQLTVCWVLRTIYLHATTRPHLSWIASSVSMHYAEIVGLHQEITAEYGTRGIELTNITTQMVEEDGPAYQLVLLFKIIMEYQIISEDSRFVYLQAFQRLDQLCDIHSPALVLLKATVCFHLYRNLFLARIKPFCVIVSILFSVIDRALESCKQLVSQRKAW", "function": "Probable transcriptional repressor of multidrug resistance genes.", "AFDB_id": "AF-G2TRT1-F1-model_v4" }, { "swissprot_id": "Q2QNS6", "sequence": "MSRRLSLPAGAPVTVAVSPVRSPGGDAVVRRGSGLTSPVPRHSLGSSTATLQVSPVRRSGGSRYLGASRDGGADESAEFVHYTVHIPPTPDRATASVASEAEAAAEAEEVHRPQRSYISGTIFTGGLNCATRGHVLNFSGEGGATAASRAAASGNMSCKMRGCDMPAFLNGGRPPCDCGFMICKECYAECAAGNCPGCKEAFSAGSDTDESDSVTDDDDDEAVSSSEERDQLPLTSMARKFSVVHSMKVPGAAANGNGKPAEFDHARWLFETKGTYGYGNALWPKDGHAHSGAGFVAADEPPNFGARCRRPLTRKTSVSQAILSPYRLLIAIRLVALGFFLAWRIRHPNPEAVWLWAMSVACEVWFAFSWLLDSLPKLCPVHRAADLAVLAERFESPTARNPKGRSDLPGIDVFVTSADPEKEPPLVTANTILSILAADYPVEKLACYLSDDGGALLSFEALAETASFARTWVPFCRKHGVEPRCPEAYFGQKRDFLKNKVRVDFVRERRKVKREYDEFKVRVNSLPEAIRRRSDAYNAGEELRARRRQQEEAAAAAAAGNGELGAAAVETAAVKATWMSDGSHWPGTWTCPAADHARGDHAGIIQAMLAPPTSEPVMGGEAAECGGLIDTTGVDVRLPMLVYVSREKRPGYDHNKKAGAMNALVRTSAIMSNGPFILNLDCDHYVHNSSALREGMCFMLDRGGDRVCFVQFPQRFEGVDPSDRYANHNLVFFDVSMRAMDGLQGPMYVGTGCVFRRTALYGFSPPRATEHHGWLGRRKIKLFLTKKKSMGKKTDRAEDDTEMMLPPIEDDDGGADIEASAMLPKRFGGSATFVASIPVAEYQGRLLQDTPGCHHGRPAGALAVPREPLDAATVAEAIGVISCFYEEKTEWGRRIGWIYGSVTEDVVTGYRMHNRGWRSVYCVTPRRDAFRGTAPINLTDRLHQVLRWATGSVEIFFSRNNALFASPRMKLLQRVAYFNAGMYPFTSVFLLAYCLLPAVSLFSGKFIVQRLSATFLAFLLVITLTLCLLALLEIKWSGITLHEWWRNEQFWVIGGTSAHPAAVLQGLLKVIAGVDISFTLTSKPGNGGGDGGVGGEGNDDEAFAELYEVRWSYLMVPPVTIMMVNAVAIAVAAARTLYSEFPQWSKLLGGAFFSFWVLCHLYPFAKGLLGRRGRVPTIVFVWSGLISMIISLLWVYINPPAGARERIGGGGFSFP", "function": "Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall.", "AFDB_id": "AF-Q2QNS6-F1-model_v4" }, { "swissprot_id": "Q39002", "sequence": "MEAVIQTRGLLSLPTKPIGVRSQLQPSHGLKQRLFAAKPRNLHGLSLSFNGHKKFQTFEPTLHGISISHKERSTEFICKAEAAAAGDGAVFGEGDSAAVVASPKIFGVEVATLKKIIPLGLMFFCILFNYTILRDTKDVLVVTAKGSSAEIIPFLKTWVNLPMAIGFMLLYTKLSNVLSKKALFYTVIVPFIIYFGAFGFVMYPLSNYIHPEALADKLLTTLGPRFMGPIAILRIWSFCLFYVMAELWGSVVVSVLFWGFANQITTVDEAKKFYPLFGLGANVALIFSGRTVKYFSNLRKNLGPGVDGWAVSLKAMMSIVVGMGLAICLLYWWVNRYVPLPTRSKNKKEKPKMGTMESLKFLVSSPYIRDLATLVVAYGISINLVEVTWKSKLKAQFPSPNEYSAFMGDFSTCTGVATFTMMLLSQYVFNKYGWGVAAKITPTVLLLTGVAFFSLILFGGPFAPLVAKLGMTPLLAAVYVGALQNIFSKSAKYSLFDPCKEMAYIPLDEDTKVKGKAAIDVVCNPLGKSGGALIQQFMILSFGSLANSTPYLGMILLVIVTAWLAAAKSLEGQFNSLRSEEELEKEMERASSVKIPVVSQDESGNGSLGESPSSSPEKSAPTNL", "function": "May function as an ATP importer.", "AFDB_id": "AF-Q39002-F1-model_v4" }, { "swissprot_id": "Q9XVN3", "sequence": "MVTTSSGGGIGYPANNGVTQVSLIHSSDSVRTVSTAPIYRPTSSMASTMAHKSSTAPFISANQRMSKPPVRVVAQPPPPHPQALSQQYHQQNPMMMYSAPNTRPHVIPTMQVQPTMAAQIKRNNPVNAQFQNPSEMIADYGVKPQSVEMVQRVRAVRRQVADEETELRRLRELEHETAQLQNKNYGRERELNVQGSMLKEAQLELRNASMRAQSLNKHLEEMYRRRQTAAAAALVEQRKMQQHQILLARAANQVSTQEVIRPRASVEPFQVNNTQQQQPSPQMMKSEEFSEKRDLNGQTGSYDAIDGSGDHQKIPTEPSYLAPCKENQQKYSELSKMASTDPHSNHSSPSTSSQKAPTLITFSPPSFEQKINSSTMTRDSPFVERPTSFGDSLDESRLRSGKTDLVSLRSDSLKATKRRSWAASEGTSMSEAEMIHRLLDEQRRGRSHFIPQLPTSQEEPSAITSETYAEEVVNSESKQVATSSDSTNNLELPTEQMVLGSDTTTEEDASSCSTRSDDGQNLEMEVAIERRTVKGILRRPNEKMNKGRIEFDPLALLLDAALEGELDLVRSSASKLTDVSQANDEGITALHNAICAGHYEIVRFLIENDADVNAQDSDGWTPLHCAASCNNLPMVRQLVEGGGCVLASTLSDMETPVEKCEEDEDGYDGCLKYLSAAHNSTGSINTGKVYAAYGYEAAFEDELSFDAGDELTVIEKDKVDKNWWTCEKNNGEKGQVPRTYLALYPSLKYRKKLNFVMFDLPLESNNNVE", "function": "Negetively regulates apoptosis via its interaction with cep-1.", "AFDB_id": "AF-Q9XVN3-F1-model_v4" }, { "swissprot_id": "P08159", "sequence": "MSSKLATPLSIQGEVIYPDDSGFDAIANIWDGRHLQRPSLIARCLSAGDVAKSVRYACDNGLEISVRSGGHNPNGYATNDGGIVLDLRLMNSIHIDTAGSRARIGGGVISGDLVKEAAKFGLAAVTGMHPKVGFCGLALNGGVGFLTPKYGLASDNILGATLVTATGDVIYCSDDERPELFWAVRGAGPNFGVVTEVEVQLYELPRKMLAGFITWAPSVSELAGLLTSLLDALNEMADHIYPSVFVGVDENRAPSVTVCVGHLGGLDIAERDIARLRGLGRTVSDSIAVRSYDEVVALNAEVGSFEDGMSNLWIDREIAMPNARFAEAIAGNLDKFVSEPASGGSVKLEIEGMPFGNPKRTPARHRDAMGVLALAEWSGAAPGSEKYPELARELDAALLRAGVTTSGFGLLNNNSEVTAEMVAEVYKPEVYCRLAAVKREYDPENRFRHNYNIDPEGS", "function": "Involved in the degradation of D-nicotine. Catalyzes the oxidation of (R)-6-hydroxynicotine (6-hydroxy-D-nicotine) to 6-hydroxypseudooxynicotine. Oxidation of the pyrrolidine ring of (R)-6-hydroxynicotine leads to the formation of the optically inactive 6-hydroxy-N-methylmyosmine, which hydrolyzes spontaneously to 6-hydroxypseudooxynicotine. Acts with absolute stereospecificity on the D-form of 6-hydroxynicotine. Shows lower activity with (R)-6-hydroxynornicotine, and weak activity with (R)-4-(1-methylpyrrolidine-2-yl)phenol, (R)-6-chloronicotine and (R)-nicotine.", "AFDB_id": "AF-P08159-F1-model_v4" }, { "swissprot_id": "A0A1W2P884", "sequence": "MWGRFLAPEAGGRDSPSGARSFPAGSDYSSAWLPGNESLWQATAVPSNHRNNHLRRHSITSDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSRSLVTLPTAHVMPSNSSASVSKHRESLTPDGSKWSTSLMQTLGDHSRGERDSSLDMKDFRPLRKWSSLSKLTAPDTRNHSGIAYPQELRNSLEMTGKGKPFMSHLRTFGPSCLHDSMELLKLEDKEINKKRSSTLDCKYKFESCNKEDVRVSSSALRRQTLDMTYSALPESKPIVTGSETFESPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRTTDDSYSLAPWQQPQTEEFQQGSETPMQVLTGSSRQSYSPPGFQDFSKWESVLKIKEGLLRQKEIVIDRQKQQINHLHERIRDNELRAQHAMLGHYVNCEDSYVSNLQPQYESSSGQSLFTEQPLSHPHQEELEQKLASTEKEVLQLNEFLKQRISQFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQNKEKQRRIETLEKYLADLPTLDDVQSQSLQLQVLEEKNKNLQETLIDTEKQLEEIKKQCQDKEVQLLCQKKKEKELVTSVQSLQQKVEKCLEDGIRLPMLDAKQLQSENDNLREQNATASKIIESQQDEINRMILEIQSMQGKLCEEKLTARSTVEELGRKEGSLQRLTEALLENQRQMGETYSLLDQGHEAEQSRPQTIHSKWPLFDLTVIDQLFKEMSYCLFDLKALCSILNQRAQGKEPNLSLLLGIRSMNCSAEETENDHSPETLTKKLSDVCQLRRDIDELRTTISDRYAQDMGDNCVTQ", "function": "Plays an essential role in neuronal cell migration.", "AFDB_id": "AF-A0A1W2P884-F1-model_v4" }, { "swissprot_id": "A8GW29", "sequence": "MQTIEQQITDLIQETLSDMGFELVLVRVKGLSSKVVEILIDRLDDQKVTIEDCTKASNTISAILDVEDLIEEAYYLEVSSSGVERPLVKFENYKRFIGREVKIKLKELLNGRSRYQGTIIEAKDDKVYLKWEDQEVIINYDLIKSANLVLTEEMFKKLLGSENKSNTR", "function": "Required for maturation of 30S ribosomal subunits.", "AFDB_id": "AF-A8GW29-F1-model_v4" }, { "swissprot_id": "Q05191", "sequence": "MASGQQERSELDRMAREGETVVPGGTGGKTLEAQEHLAEGRSRGGQTRKEQLGEEGYREMGHKGGETRKEQLGEEGYREMGHKGGETRKEQLGEEGYREMGHKGGETRKEQMGEEGYREMGRKGGLSTMNESGGERAAREGIDIDESKFKTKS", "function": "Lea proteins are late embryonic proteins abundant in higher plant seed embryos.", "AFDB_id": "AF-Q05191-F1-model_v4" }, { "swissprot_id": "A0LJK2", "sequence": "MARITILPDILCNQIAAGEVVERPAAVAKELLENSIDAGARRISLSIADGGRKEIRVVDNGSGMHPDDALLALERHATSKIRSIEDLQAIGSLGFRGEALPSIAAVSRFELVTREPDAVAGTFIRVEGGVVREVRETGSPAGTRITVRDLFYNVPARRKFLRAADTETAYICDQFQRLAMAHHAVHFQLINRERTQYDFPGAASPEERAGQVLGAETLKRAIPFCVENASARLRGMVGTPDLQRANSHSLFVFVNGRPVWDRAVNRAILAAFESLIPRGKFPVAVLFLELDPLHVDVNVHPTKREVRFKHPGGVIDTVRGAIRDALCHLRPLHGSAAAAPRPFSETADQRAFRDSLVREGQLSFDRGRPLSRPPGFPSERWRERHRPDAEPPYPLLREPAPTENPRREAGSPPAAPADSLFDEGAAPQPDNPDTDFFAEPKRAAGGPASTHAPVTVDTAAFADAFQAFEAATHLHAGDVPALAELPVIGQLANTYILLEAPDGLILIDQHAAHERIIFDALSFPAGGPARQRLIRPAVIDLPPRDAAMLRRWLPLLEEIGVEIESFGGDSFVVHAVPAPLGECPPEGLVRELLASAIEGDDAPRWNVLGRLAKTAACHRAVRAGQRLRPEEIRLLLEGLDRTRFASTCPHGRPVWYKMTLSDVARLFQRT", "function": "This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.", "AFDB_id": "AF-A0LJK2-F1-model_v4" }, { "swissprot_id": "Q21432", "sequence": "MTPSLVFLIVVIVVVEGQGWRPWDRFNHPGNFGNWGGNNWGTRQRNQEPHDIPPPVPPPGFRGNNDRFGGNIIKVVEIIDLGKSKNRGDILSDFKDVHKKHRHLGRKEWKGKVKQFCHRFPGHPNCRRGKVPDQKELEEMIGQFSKGGIGRFLKRVPKIYIEDPLARVDPKLKGFLENAGRGFGHVSSEHVNKLRDICKRRKCREQPESAKKTRELFTQKLADFETKIAGKDKTDSVQLRFDRTLQIKEALLEKGNLTADIVPVDNGVYDLDTMLTEEQANILLNELNKAGVGDDEIPLPDADTDDEDDDDSTNSASGAAPGSSRLKKSALYFEGNLIKKWDPSSPIRYVLDSSLEDLDKNDVRAAIYEIEKNTCIRFKELSSPPTGSHIVYYKVDSPTFCGLSYVGRADPANPVYLSFGCDNNKGVAIHETMHALGVAHQHLRNDRDQFITINWSNIDPQQYDAFVVVDSKLYTSYGVKYAYDSIMHYNGYTAAQNIAIPTMNPKTNSAVNLKVLGQRQKMGTTDIELLKKMYCQPGCDDKNVYCGAWALKDLCKNPGHDQYMAANCKKSCGLCAIGK", "function": "Metalloprotease.", "AFDB_id": "AF-Q21432-F1-model_v4" }, { "swissprot_id": "O74310", "sequence": "MDFEIENESEIPQLVDVEEVNTQPHSETLSVPTVSSNNDIDSFEQQSDFLLVDHDSTLDPVPVTILTGFLGAGKTSLLRSILENRNGKRVAVLMNEVGDSGDLERSLMEDVGGEELYEEWVALSNGCMCCTVKDNGIKALEKIMRQKGRFDNIVIETTGIANPGPLAQTFWLDDALKSDVKLDGIVTVIDCKNIDNILKDESDIGFIQISHADCLILNKTDLISSEALSVVRQTILKINCLAKIIETTYGRLDDISEILDLDAYGNENTSNLEWSIQRSNDSNINCSTCLDVDCQHLHSLDTHSLDISTHTFKLPPLMSKEVFQQFLQWVRHTLWSCLEEGEDEEFMIYRSKGIFNKDDGSWYIFQGVREVFEIMPLSEKPRAFLEKDIHPEIILIGRNLHRISPFVVGNQ", "function": "Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase map1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of map1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of zng1 to the zinc binding site in the peptidase domain of map1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active map1.", "AFDB_id": "AF-O74310-F1-model_v4" }, { "swissprot_id": "Q05632", "sequence": "MKDELFLRGENVPMTKEAVRALALSKLELHRASHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPAALRLLDENRQRFACGNIDILPGEAPMTITGKADAVFMGGSGGHLTALIDWAMGHLHPGGRLVMTFILQENLHSALAHLAHIGACRMDCVQLQLSSLTPLGAGHYFKPNNPVFVIACQKEENHVRDI", "function": "Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.", "AFDB_id": "AF-Q05632-F1-model_v4" }, { "swissprot_id": "P96122", "sequence": "MTVGVFAALGEEVARVRECLGGVGTERAGLTFYVVSVGALQVVYVCGGVGKVNAALCTQLLISEFGARVLINTGIAGALDERLCVFDVLVSVDAVQHDVDVTAFGYQKGRIPRMDSVEWTANTALRYLVREAFDLCTRDPEWTEGACALSGSGDPPSRVSRLVEGRVASGDLFVSDAQTRARIIREFGAHGVEMEGAAFAHVASVNGVPFVIIRCISDGAGAEQDVSMSYKEFSTRAARRSALLTLRVLERLSALRTSVVASLFPMVVV", "function": "Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.", "AFDB_id": "AF-P96122-F1-model_v4" }, { "swissprot_id": "P33257", "sequence": "MASMQDLKRRMESITVTHKITKAMKMLSTVKLNRFKATLGKTKEFYQEFYEVIGAVITNYNKTKPRTTTPTNQSTKRLWIVINTQLGLCGSYNTNVGKLLVSELAKDDEIILVGTKLNSFLRTRNHEDQIIHTYSINDKNIDFESSYMIGKHVLELHEKNQYDSIDCVYTNYINSLNFEAKKIQLIPADPSIFQADTLDRINDKFPKNISFEPGVDVIIPALEKQLLQVILYGCLIESKVCEYASRRNAMDTAAKNADDLYNKYKLLYNQLRQAKITQEINEIVAGAAK", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.", "AFDB_id": "AF-P33257-F1-model_v4" }, { "swissprot_id": "O95568", "sequence": "MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHLWEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKIIDEGLKRFIIEITFKFPG", "function": "Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3. Through the methylation of RPL3 regulates the dynamics of pre-rRNA processing, ribosome biogenesis, and translation.", "AFDB_id": "AF-O95568-F1-model_v4" }, { "swissprot_id": "Q4V7B0", "sequence": "MAPKKKSNKGGKEIQSKKKIGGRKDTSGSKTPELAMVEELKEFYHKQIQDLEDRLARYQRKWDELAVQEKLFRQEFEQLANNKKEIVAFLKRTLNQRVDEITDLNDQLQSLQVAKEMEKDAFEAQLAQVRHEFQETKDQLTTENIALGIKLSSLEEFRLQKEELTEKYMALEEQLRRQEGEYKDYVYNLEKKSVLDKDRLRKEIIQRVNLVATEFRKVATNQMWETTRRAILENNNVTLQLSKVSKQGVQLLQENEQLKGAQGKLCQQLELLENTQEIMAKKNIGNQKVILMLTEKCRQQRKGTEEAEQLRLQLFQLEQNIETLEKANQTLRSEKDQLDEQLKEQRAEANRLQEELTKEQKIRTNLKTVLTQATSLLRDILQMRPETEDGDFDVVFQLQRKELLQQLLVLLSSAVVSKPQQDMGSHQDKQPAGLSKDSRLIAQTSKQGAASLLQQLSTITTYQPGDLGLVPRRLQVHIPPKPQDLRPLSCVTRMGICKLQNTTEIYPSGALKRFKKFTLPRPFLHTGRPSRCRKPDVAPVPP", "function": "Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure.", "AFDB_id": "AF-Q4V7B0-F1-model_v4" }, { "swissprot_id": "P10841", "sequence": "MDPRLRAPIFLPILTPETLQKKKQIKGNKTTIYKNGFMLFRSRLHKILNLSGDWAGASAKCSIIWHTLPQNVRLAWSQLAELSHYQDVRRQIAKLERILYSKRLNGHNNYKLHISRVQ", "function": "Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Required for conjugation and efficient meiosis.", "AFDB_id": "AF-P10841-F1-model_v4" }, { "swissprot_id": "Q7N964", "sequence": "MNNLPNAPFAPTEHRLGLYPVVDSLAWISRLLQTGVTTIQLRIKDLPEDQVEEEIQQAIMLGRQYNARLFINDYWRLAIKHGAYGVHLGQEDLVIADLNAIQKTGLRLGISTHDEQELARAKSLRPSYIALGHIFPTTTKAMPSSPQGVEALKRQVENTPDYSTVAIGGISLERVPDVIATGVGSVALVSAITKAKDWRQATAQLLYLVEGIELKG", "function": "Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).", "AFDB_id": "AF-Q7N964-F1-model_v4" }, { "swissprot_id": "A1Z7Z9", "sequence": "MDLCLKGSQINLATRQKTKPKYTSRSLTTLHNPCPHFRPRSANFLQQRSRSSPFLGRPQSADPKFGRRLSNYFVEKELRNGGKRQVSSNDLLKSLLEEPIKRSWLCRSTCNSSESDYSLHKRTPDSSEEGEQFLVNMPVGEKVKSYSSYSGNQGLSNGALLQRTAKPDLPGRVSFSKPNMHADLDSSDCDNDKQEVRPSISAPGPLTLPSFLSKVEQADPVGQKKSVHFGSTAAEGEVLAETYEYPKCPSENCTCSTRSSSTTSTNEASASDVKCACDAPSCRFMESSKQVEPTSPTPTLPKAPSSELDVIREYKQAVEGVQVVKNHLGTDTLNNIEILPNYLDKYASPTKEKQNNLSETKNMATNSSAVNNGSVVYRPVGNPRNFGAENNFLPAVQDDRRSFANGSSDGVINNYLKVASTPPFVGKKKENVKPASADPIARSSKSKVTKSTINPAPLGKMKKAISVGSLREERKLSEYNLDKVDSWMSMQDQKQYDGKHKPGLEDLDEAQDNDTASQLSLKSNEDSRDSTYDEIVSVIKEIEEDKKRDNFSEGIPSELNLNLDSRCETADTVTVSEGKVPESGDKYKDILAYLNNVESSCDKTLMETRRSIPDSNRSEVEFVVEPDVTDEVPKLSELLMLPNHQLARRVIALSLRANELANAIHMSKEHVFQLRGEKQKSLRAEKSTAAAKLRDQKKHYEEVVTRHQGFIEQLLKDKGSLCEKVAALTRRLESQNQAWEHRLETELARTKETTMAGEKIRRERWVRENTKKIKELTVKGLEAEINKMNCDHQREVTELKRTHQMQLLDALEEARTKHEQIETSIRESCAQDREAIIEKERTAIRERFERQLEEEQRTQAEQRQKLTEEFAAERDRLQSELRQRENEHQARRQEALREQEQELEQAKFEMQERMAKQEEKYQNRVNTIEQQYQADFELWKTEHENKTKLAQAEKENAIRQHYRAERDRQLDELVVRMEADALQHKEEHELKMNRLKEKYEKDLVLAESVEKSLREKYAETRGKLAEADAQVRNSQAEVKQLQLELSHSKKMCGDIIMERDRLRDNLNADIQSELGVLNERHKQEMDQLQKRVHQTIQRQEETIEILKGDNDALRQQCLKLNAVIRQQRKDYCVK", "function": "Cilium-specific protein with a role in cilium/flagellum formation. May be involved in transport of components into the growing cilium. In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme.", "AFDB_id": "AF-A1Z7Z9-F1-model_v4" }, { "swissprot_id": "Q54SU1", "sequence": "MTMITIDYIKDIIKRSDKLSEEIDPDQTPYKSKYEAIELLVKELKKEINENEKELNQQQQQDILDYLVVIDSKLGELFIATEEITLGLNICRDCLKSLESIKNKFPLETISTFQSIAIIDINKNHFENGKQLLIKSENLINQTIEKQQEQEQEQEQQFKDKLESLQLQNYFYFAQLYGLLKDSELSSKYCELTLRKQLKRNNFDRLEWCKNSLMLAEYYLSELNFDYAKQCFLVSNYICKGIENEDDREETQANIYLVMAKFYLEFLHFFRDIENLNHCHRVNNNNKNNNNENDIDFVQGGLSSISLSDKQKEKEKEDKLFNENQIKKEKMLDLISFNKRSLNIDKPLFTELGSELLDKIYNHSTFTSPIDLIVVKDQPSARDIFLKSQHFFNKSKKYYKLDGFVSQHIKILFDQINLFEYLNMFESNAGRKIGIHKKKIELIQPLLKELNPTYFLSSIRSIYFKIAEIYSEISKIYQCVCTNLREIQTYNECLFKSMEYYNLFLNSYNDGEVPNSPKITEEEKMKSIIEDFEVYINAKLELAVCHKNVKGVNKLVLEHLEKSLNLFRSIITLLDSVPKDISSRHTQEYHLCSQMSSLLPQKIQFLSSNKTPNPGQWYGK", "function": "Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.", "AFDB_id": "AF-Q54SU1-F1-model_v4" }, { "swissprot_id": "P42205", "sequence": "MQEPKQTRVRYLILLMLFLVTTINYADRATISIAGSSIQKDFGLDAVTLGYIFSAFGWAYVLGQIPGGWLLDRFGSKKVYAGSIFTWSLFTLLQGYIGEFGISTAVVLLFLLRFMVGLAEAPSFPGNARIVASWFPTKERGTASAIFNSAQYFATRAVRALDGLDRLHLRLAARVHRHGRPGHCVLAHLVDGDLRAERSPAGYAAEVRSSPHGGLVDLEDSKDKKDGGPKWDYIRQLLTNRMMMGIYLGQFCINALTYFFLTWFPVYLVQERGMTILKAGIIASLPAICGFLGGVLGGVISDTLLRRGNSLSVARKTPIVCGMVLSMSMIICNYVDADWMVVCFMALAFFGKAIGALGWAVVSDTSPKQIAGLSGGLFNTFGNLSSISTPIIIGYIIAATGVSKWRWSSWVPTHSFAAISYLFIVGEINRIELKGVTDEPATTAHPGELLPTTRKV", "function": "Probably involved in the uptake of galactarate and/or D-glucarate.", "AFDB_id": "AF-P42205-F1-model_v4" }, { "swissprot_id": "D4AX63", "sequence": "MMFLTQLVSALFLFFLGPISYGKPVETFVLPLAQDAPIPPSEDPFYQPPPGYEETEPGTVLRQRRPPFPISLFRSAPIDLAATYQVLYRSSDTFGQPTATVSTILIPHNANMSKVLSYQVVEDAAFINCAPSYALQLHSDPGGLFGTIIIQSELLLITAALENGWVVTIPDYEGPAAAFLAYWRAGYATLDGIRATLASSGFTGVDPDAAVGLWGTSGGSVASAFAADLHPKYAPELNIVGAALGGVVPSITTALHSLNKGFDAGIIVSGVIGLSKEYTYMQPILESYLVPHLRDKFMSAGKKCSGAVSLDFRMEDIFSYFKGGEESGLFADPRVKAILDHNAMPQGVPEIPILILKSVNDEISPISDTDALVEKYCSNGVTIDYKRDLLSVHTILAVTGAPEAVLWLRDRLDGITVEKGCKTSTIFMTLLQPGALEVMSKTIIDNLLNLLGKPVGPRLRTEIVHVPPL", "function": "Hydrolyzes triglycerides, with a preference for substrates with short-chain lengths (C4 to C8).", "AFDB_id": "AF-D4AX63-F1-model_v4" }, { "swissprot_id": "Q9M8X2", "sequence": "MDRPPSLPHYQNPNPNLFYHYPPPNSNPNFFFRPPPPPLQNPNNYSIVPSPPPIRELSGTLSSLKSLLSECQRTLDSLSQNLALDHSSLLQKDENGCFVRCPFDSNHFMPPEALFLHSLRCPNTLDLIHLLESFSSYRNTLELPCELQLNNGDGDLCISLDDLADFGSNFFYRDCPGAVKFSELDGKKRTLTLPHVLSVECSDFVGSDEKVKKIVLDKCLGVLPSDLCAMKNEIDQWRDFPSSYSSSVLSSIVGSKVVEISALRKWILVNSTRYGVIIDTFMRDHIFLLFRLCLKSAVKEACGFRMESDATDVGEQKIMSCKSSTFECPVFIQVLSWLASQLAVLYGEGNGKFFALDMFKQCIVESASQVMLFRLEGTRSKCSGVVEDLDDARLRNKDVIMEKPFENSSGGECGKTLDSPQVISVSRVSAAVAALYERSLLEEKIRAVRYAQPLTRYQRAAELGFMTAKADEERNRRCSYRPIIDHDGRPRQRSLNQDMDKMKTREELLAEERDYKRRRMSYRGKKVKRTPRQVLHDMIEEYTEEIKLAGGIGCFEKGMPLQSRSPIGNDQKESDFGYSIPSTDKQWKGENRADIEYPIDNRQNSDKVKRHDEYDSGSSQRQQSHRSYKHSDRRDDKLRDRRKDKHNDRRDDEFTRTKRHSIEGESYQNYRSSREKSSSDYKTKRDDPYDRRSQQPRNQNLFEDRYIPTEKE", "function": "Likely involved in U12-type 5' splice site recognition.", "AFDB_id": "AF-Q9M8X2-F1-model_v4" }, { "swissprot_id": "Q6CME1", "sequence": "MFKRGSNRATSSSQGQQPENPPSLKYQSSSSRYSFHRQYNTGFGTSPFRISPKYKPDSRTPFSFDGTGNVGPESSLNEEESNARWRPSESSFDKRRTFHGAKYSLSIGKEVSSIDKINSPESRSLIIAGKSHLGIYTFDEDSKTITNVHDFLQTAKTNTGITKNTSSTLRRTTKKISTISDVKAGFYNHKNYVAICGTSTSVAIYDINKTSAIDNPVVTSLSEHTRSINSVDFNMVQTSLLISGGQDGCIKIWDLRSPKISTTRSDVSINTGSDSIRDVKWMPSYEFSNDTNGLSNRHFKFASVHDSGLLLKFDLRQPNQAEKKINAHSGPALCLNWHPHQDYIISGGRDGKCCLWYVGDKSNQVGNISSTNLNSSNPATHNLSSSYPLGLSNTLAFPELTINTARSMNKLKFRPKYETNVFNSLIGTSSMGEDSDVSVYSLARKYIPKNVIASSAPSVGFVWWDDDTIFNIDKQNTVTGWDISHEPTVLDNLPKNTIKWRDLDGDGILFLDQKPGGYLSQEETVLTPGSGENRKMPFTHRMSSATANSFTGGNNPNITSNTSSSAASFSKNPTLGMSQLHQGNVLGERSTMSKHAQSVNSKFSPSVNSSPWTNPYSSPHHNSIVSGSESALHAVNDSFLQSPYLIGLDFPHILNTIRNTRLAEFNRKVESAALLELKSSPTEVFKFLARELKFSYKYNSIETKDNGRELDSSSTHGSVDSKTNLMEKLGLSENNTWTHLIKYTKSHDSDEVISKGTELKTPVSDKSANIEKSATNHKAETNQDENSSCINSSNQVKTKNLIELITLCDKNAEIYIMLEDFSNYKIWLLMRDSLLWDLKVLTESMAVDVTADQEVNDQSSIDQPWKKNDSFTSLKEARQASVASGYSSYSATDLSSSVNTNNRHSFNEPTHLTQTPPVSHLKAQLQGSKETTTISRADSIQNSLQNDIIEIRKLRQSHGDRAELAIDEEEEGEEREELTKRAFEEDENNKQFINIPRRESGPSALMPSPSHVSSQSEIPSNPENHHQPRRPRTSFIDSFMSQLRSPGSSNVDADRESTGSKKSSMPSFSSSAATFLNSKKSQNANHNKLKSATEVSDILESEFATQKSWNGSVAKTTTQMSGITALMNETKKLENTITPPWSSRRLIHQLYEQSVASGNILLTMAILLLFQDMFQLVDTETVKNSIAEFTELLHRYELFEIAAELMKNCPYEDISSSSAGFSSIQLFCDKCNKPLVNESSKEKIIKERLEGNSSAMSRFGYWYCDSCSKRNTLCCFCNKPMKSLAISMLNCGHEGHFECLKKWFFDENMDVCPLGCPAILF", "function": "May be involved in a process influencing telomere capping.", "AFDB_id": "AF-Q6CME1-F1-model_v4" }, { "swissprot_id": "I1RF54", "sequence": "MSSTDPLLRRVENYRESCDNCAKSKVRCGKEQPWCQRCERRGQVCSYSPSQRSRKRTLDAAHPESDQRNGTPPFTAISSASSVAAVSTGFSSMLSQADSWGTCPDLVELLTSGSSSESLTPDNNHLVWLSDMESIAGDSNISKSMERMDVFPYPKSIASSAAGVVNGSGAGADSMGRRSTCPLQNKQHCEADLISALAKPELPSLSCWGNPKASQNLGTILTASRATLKCVTTAMSCTCTPNDNVALLATAVLLRILSWYHIVLKNCNGPNDTSAATIDDHTSPTPSNDGKDTERSVSRDTNVSQDGSEPSSLIMPPMTIGAYELDSENRERMIGHIMLSELGKMGNLLSDFSKKFCDPQSTMLGNDNRSQLFLALEMLIRNKHMATVLDVRKKLEVK", "function": "Transcription factor that specifically regulates the expression of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin.", "AFDB_id": "AF-I1RF54-F1-model_v4" }, { "swissprot_id": "O74360", "sequence": "MNSGTTLHLDRLSLETPSERTCFCIKCWESVPSTSQVWFGGKCWHSDCFKCVNCNKKLDPSSEDFSQDDQKQIFCKLCVDICNGCSTPICEFNAVSNSQANHPCCSNCRAFINSNAFGKFKGQHYCLPCLRKQDEENQKAVMESASGFIPLRNIAQTAENTSLTGQNQGFQNPHFIASDSPSSVLSGRMQNTSSPTNSLRPQLKVQTNGYETPGDINSAKSYKDIQKDFLLKPKNSFVKTSPSPLANGPSFRSANASPFDSCDSFHSGSSIPIEPVSSRQSSVVNNNSVQQPVAYHAFVQSPTENGTLPQLPKNESVVNPPPLRRSSTMNYKSVSTTTSPSKYGYVSGRIALSPIHLRGALRDVTNKCNLKVPRNRNSLSNLDEYYVNGLESDETPTKARFPRYPTVFNKLDDKRLSSEPNGLKKRLTNSSNYEASPRAKSLNLSQVSLHQACEPEYNRSSLVRASDVFTSNVFDATEESANELAIRISELQAEVGTLLLEATSLASIIEQQTPVSPEAFKQELVADLNYRLDYLRKSFQPELSTLLLRRDALSTTVSKLQNAYSTVMEETAYLNVKNTELVSLNNQLERELAYLREQQHKKRTSSSFGIFNNDKKSNRTISTPSPRESFSRLQMVASSLGFRPKDNKDKESGGYNKRNSKIDLKKSFSKRFHWKRDSPHMSSTPSISEEHLASEEQEDFVPAVGHCKLCGKYSNELRAHYQDCVSSTIDRQYQSKKSESPVWALNPDDFDQNRLTLLRVPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVLDPSEDISAVTSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDKLDGFIMVIKSLPPAHAEILQLIIRHLARVAAYSHANRMTSKNLAVVFSPTLIRDPDNSRDVIDMTVKNYSLAFLIDHVHEVFA", "function": "GTPase-activating protein for Rho-type proteins.", "AFDB_id": "AF-O74360-F1-model_v4" }, { "swissprot_id": "Q2W8P6", "sequence": "MDIRPERMLSRIRQMAEGAVSPQLVLGLGVVLILGLVVSAMLPDRFTGGGKTGGGVTAQSQALSLPAALPGLSPFTPATPLQFSGRVTQVASIGNDVGWGQVHIWIDNGTGALQEISVAPQAYLTQIGCPSFDGARVSGVGFIFDPGRPNAELYVKSIQVGGRTCKLRDDEGLALWMVVQ", "function": "May play a role in magnetite crystal growth and size.", "AFDB_id": "AF-Q2W8P6-F1-model_v4" }, { "swissprot_id": "Q5RKG1", "sequence": "MSLIRVNRFGPRGGARKTLKVKKKAAVRQEWDNTVNDLTVHRATPEDLVRRHEMHKSKNRALVHWELQEKALKRKWKKQKPETSSIEKRKLSIMKEILSDQYQTQDVLEKSDHLLTAAKGLFVDVPRKRTGFPNVTMAPGSSRSPAGINQDPGTQSILNESIIEPQALNEVDDGGAESTAHSQSEDSESELPNSLSPHSNRNTERFLHQLKEENSELINQLWTDIQQKIAAQSQRTPPGSPSSELSAEDQKGALNATDAVKRIQAGLQPEESAEPVDSSYVGQVLNTRKPKPLLSKVKRKQDMRALSKQKKNMLSSSTTSADLASSNNSSLDVLKHMIHEVEHEMEEYERWTGREVKGLQGGQGLTGFTLSLVSSLCRLVRYLKESETQLRKEVETRQQLEQMLGDHRELIDALTAEILLLREENGAVQARLQQYMVTTDEQLISLTHAIKSCPVINNSRQESQAPERAAMGRRLVDNVGAPVVNSNVSMPLMLKGEEMVDFPQEELPVKLSQGPPPTENLNLASNFPTHIFEPAVMLTPPRQKSNSEFSPLQDVLRRTVQTRPAPRIPPTVEVIEKEQTWEKKNLPIDPDIQNSSEESRLFTQRWRVSHMGDDLENKSQPQFVSLSQPPQFVSLSQPPCSSPPSTQQSRNPVFSEEPTVLGDGQQLGTADALMHRKDIMARIAELTLQNSAMKAHLNNITSSGGEHGDGLREPSRQGNASEVPANFPAVQSLMPSSMEERIAELNRQSMEARSKLLQLIEQQKLVGLTLSSSPVSPVESPLRAWTEEGKRTIEVSVPGVEASESSKCNTVSPVSGVSSRRSSGAISNSCSPLNATSGSGKFTPVNPRTKQTEKQSEEGWFALSAHLP", "function": "Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.", "AFDB_id": "AF-Q5RKG1-F1-model_v4" }, { "swissprot_id": "Q8MKK0", "sequence": "MFNTRLAIFLLLIVVSLSQAKESQPFDFFEGTYDDFIDCLRINNITIEEYEKFDDTDNLDNVLKENVELKHKCNIKCQLEREPTKWLNARGEVDLKSMKATSETAVSISKCMEKAPQETCAYVYKLVICAFKSGHSVIKFDSYEQIQEETAGLIAEQQADLFDYDTIDL", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.", "AFDB_id": "AF-Q8MKK0-F1-model_v4" }, { "swissprot_id": "Q9CAR3", "sequence": "MAGSEAVEDKEIKSAVSSCEAYFEKVQSRKNLPKSLQETLNSAFAGIPVSSFPQVPGGRVIEIQAETPVSEAVKILSDSKILSAPVINTDHESSLDWRERYLGIIDYSSIILWVLESAELAAIALSATSATAAGVGAGAVGALGVAALGMTGPVAAAGLAAAAVGAAVAGGVAAERGIGKDAPTAADKLGKDFYEVILQEEPFKSTTVRTILKSFRWAPFLPVSTESSMLSVMLLLSKYRLRNVPVIKTGEPDIKNYVTQSAVVHGLEGCKGRDWFDHISALPISDLGLPFMSPNEVISIESEELILEAFKRMRDNNIGGLPVVEGLNKKIVGNISMRDIRYLLLQPEVFSNFRQLTVKSFATKIATAGEEYGLAIPAITCRPDSTLGSVINSLASRSVHRVYVAAGDENELYGVITLRDVISCFVSEPPNYFENCLGFSVKEMLNR", "function": "Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants.", "AFDB_id": "AF-Q9CAR3-F1-model_v4" }, { "swissprot_id": "Q5XI46", "sequence": "METAIEDAGLDRGPTLTSSWDAACGALTQSLFLTRTGPRAQDLDFEQLLAPPAQGPDLVSLKSSLSPRDENPCFIYLKCGPNGGEEILSVGILSSARNMEVYLGEEYCGTSRGKNVCTVLDNSEHEKILLYKKYLKLESPTHACKIKLLSFGEEQCVLISKVVVHLRPRSAKPSPSSPALGSRIDLDNIQTIMESMGSKLSPGAQQLMDMIRFQQQNCLPIRDQLQSVLGTAGHKHLMALQSSPSSGVVDKASSTPFPFRTGLTPSAITENLKALIDKSTQPSGEGNTTNHNECHLMPQNHSLESDLKNAVSSFLPKKASGSSSVPNSELLPFLQNLCSQVNHLRVGHNARWQENVSKPREGTVGVPLEEQPVCSYLEKILSKNMEVMEKKLMKHIDERIYQLQEHIDAKMALLVDLLRSPNSPSPGMPLRHYDSRERLSNGER", "function": "ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival.", "AFDB_id": "AF-Q5XI46-F1-model_v4" }, { "swissprot_id": "Q21156", "sequence": "MTQFSALALLLIVFVAASFAQSYDDVSAEKRAMRNALVRFGRASGGMRNALVRFGKRSPLDEEDFAPESPLQGKRNGAPQPFVRFGRSGQLDHMHDLLSTLQKLKFANNK", "function": "Acts as a ligand for the npr-22 receptor in vitro.", "AFDB_id": "AF-Q21156-F1-model_v4" }, { "swissprot_id": "Q9M086", "sequence": "MDGQEHAEVPNSMVEDDQSVVAAEAIAELANSTGEPNPEEGEEQSVEDELIAKAQKLMEDITSVANNPNPNILHALSQLLESQESLFLEENGHFSNARGSHNSGKLCILIRENDEFFELISSTFLSENSYSTAVKAASARLLMNCSLTWMYPHVFDDAVTENFKNWVMEEAVKFPGEDSAKKEASDFEMLKTYSTGLLALSLASRGQIVEDVLTSGLSAKLMHYLRVRVLKEPSTSRIHTTETKHVSLKTKEEGRSRVRKIVDTVEGDHVLETDSGREMGQTDVQPDGEFEIDGRDVFNVSGVVDCKIKPGDDNSVRDDPSRHRLNRSKSRGRGRVHEGAPDTEVLLASPRLGRLLVRDRDLSKISDGRNAEDVTVCLGKMKSGIMEIEREDNDECFQGCIIGTKNITDLVKRAVGAAETEARAAHAPDDAAKAAGDAAAELVKTAALEEFKSSGSEEAAVSAATRAAITVIDAAEVSRNPTCVTSDQTTDVSEVSLPDIESLAQLQEKYCIQCLEILGEYVEVLGPVLHEKGVDVCIVLLERTSQLDDRSTVSPLLPDVMKLICALAAHRKFAAMFVERRGILKLLAVPRVSETFYGLSSCLYTIGSLQGIMERVCALPLVVIHQVVKLAIELLDCSQDQARKNSALFFAAAFVFRAILDAFDAQDSLQKLLAILKDAASVRTGANTDRSAPEVMTSSEKQMAFHTCFALRQYFRAHLLLLVDSIRPSRISRGGVPSSMKPNIRAAYKPLDISNEAVDAIFLQLQKDRRLGPTFVKAQWPAVNNFLASSGHVTMLELCQTPPVDRYLHDLLQYAFGVLHIVTSIPDGRKAIAHATLSNNRAGIAVILDAANISNSIVDPEIIQPALNVLINLVCPPPSLSNKPPLAQNHQPVPGQATTRPSTDVAVGTQSTGNAPQTPVAPASSGLVGDRRIFLGAGTGSAGLAAKLEQVYRQAREAVRGNDGIKILLKLLQPRIYVNPPATPDCLRALACRVLLGLARDDTIAQILTKLEVGKSLSELIRDSGGQSSGTDQGRWQAELAQVALELIGIVTNSGHATTLTASDAATPTLRRIERAAIAAATPITYDSKELLLLIHEHLQASGLGDTASALLKEAQLTPLPSSASPSSIAYSTTQEMSTPLAQEQWPSGRANSGFFTSKPKVCAHDEDPNSRSNAALSAKKKHLASSTLEMPTPVAQQQWPSGRANCGFCPSIPKINARDEDPSSRGNAAPSAKKKQLTFSPSFSSQSRKQSFSHDALPQSTQRINCCSNSDPALADTSETAAELVLKNDLDADAQFKTPISFPRKRKLSELRDSSVPGKRIDLGERRNSTFADGSGLQTPASALDANQSGSSRLGQMTPASQLRLPSDPQPSNPERLSLDSLVVQYLKHQHRQCLAPITTLPPVSLLHPHVCPEPKRLLEAPLNMTGRLGTRELQSFYSGVHGNRRDRQFVFSRFKSWRSFRDETALFTCIALLGGTNHIAVGSHAGEIKIFEASSGSMLESVSGHQAPVTLVQPYVSRDTQLLLSSSSSDVQLWDASSITGGPRHSFDGCKAAKFSNSGLQFAALSCEASRKDVLLYDVQTCSPCQKLTDTVTSSRSNPYSLVHFSPCDTLILWNGVLWDRRIPEKVRRFDQFTDYGGGGFHPSRNEVIINSEIWDMRTFKLLRSVPSLDQTAITFNSRGDVIYAMLRRNIEDVMSAVHTRRVKHPLFAAFRTLDAINYSDIATIPVDRCLLDFATEPTDSFLGLITMEDQEDMFSSARMYEIGRRRPTDDDSDPDDDDETEDEDEDDEEEDDLDRILGLAGDNSDSGDDDLSSEDNEDSVSDFDEEADILIDGDFMEELIEGENEDDGNGEDEDDDDDGEMQDFMSSGEEDDYRDNIRSS", "function": "Component of the CUL4-RBX1-DDB1-DCAF1 E3 ubiquitin-protein ligase complex, DCAF1 may function as the substrate recognition module within this complex. Appears to be required for plant embryogenesis and to affect several other developmental processes including leaf, shoot, and flower development.", "AFDB_id": "AF-Q9M086-F1-model_v4" }, { "swissprot_id": "Q2S4C3", "sequence": "MDTIELTLTIPPVEHAPFLAELEEPATGFVQNDTELRAYVPAERWAAVDQKQLKARLAADGHPDALSIRPLESKNWNAVWEDTLSPVRAGPFLVCPTSVAPPSARDDATVLRIDPEMSFGTGHHATTRLALRLLAEALAPGDRVLDVGTGTGVLAIAACRIGADAARGVDTNPDAVRNARENVRRNEETDCVTVQEGSVDVASDTQYDLVAANITRRVLLELMPALVARLAPGASLLLSGLLRPQRDDIRDAVASHGLALDAEAAEEGWWAGRFARSPSP", "function": "Methylates ribosomal protein L11.", "AFDB_id": "AF-Q2S4C3-F1-model_v4" }, { "swissprot_id": "Q550C8", "sequence": "MGSPTHFGLFLISDAEREVHMEELKSQEASKSKPPSKPKSNFTTFSHGTPDLSKIHKVGMLATVCRTQGYFVLGGGPIIEITGVSNDHDNNNSNLVEITESKNDTSDSTTTTTTTPSTSITPITTPVVPQIPTSKYLKVSIEPHEYSELGDSLTVRALRLQLVKCIYSAINRYQDSSFAQHLKQICMLPIFKMDDSSLLNSIGPLCISSPSEYQKLLECKSLEEKLNMVLSMLVKKCEVFDFNFSIEKQLEEKTMAQQKKYFLTEQMKLIRKELGIDLDEKETIKNKFNSRWKEIAVMDKQILQVFKEEMDKLSSCESNSSEYNTSRNYLDWMTLLPWNVYTNDNFDISKVKEILDRDHYGLKDIKEMIQTFIAVGKLRGSIGGKVILLVGPPGTGKTSVGKSIANALGRQFHRISVGGLSDVSEIKGHRRTYVASMPGKIIQALKTVKTSNPVILIDEIDKISRSSQGDPNSALLEVLDPQQNKNFVDYYLDVPYDLSRVLFICTANDADSIPAPLLDRMEVMTLNGYIQSEQMEIAKRYLLPLVRKETGISEEQLQFTPEAIKKLCELYCREAGVRNLKKFIDKIFRKMAYKLSMGMEQSVIITPDNLEQYVGPIKYPSSRLFQKQKPGIVMGLGGSLIHIESALDRFTNGPTVTTTGSLGLVMRESIDISYSYVKDFLLKVDASNDYFLKNSIHIHAPDGSTQKDISSAGITIVSSLLSLATGKLVKPDLAMVGEVSLTGKVIGVSGIVEKIVLAKRESIKTIIIPKENKKQLEEIPDFIKEGIEIYLVDYYSDVYSIAFTNDSTIKPLIFNDNKENQNENENQSEVKSTIIQ", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.", "AFDB_id": "AF-Q550C8-F1-model_v4" }, { "swissprot_id": "Q4WKX2", "sequence": "MRRATLIPLAIWVAGAAAAAAASLPQFPSCDISLANIGLSQNSQIFFPNGSGWESETIRWTKYMAPTYAVSVRPAHVSDVTQVRFATRCKIPFLASSGQHGFDTELAELQNGMEIDLSAFRNVSVDAKKNTLTVGGGVRFMDVFDPVFNAGKEIRTSETDHQVGTGSGACVGMISPTLGGGVGRLSGTHGIISDQLLSVQMVTANGSLVTVSKKENSNLFWGLRGAGGNFGIVVEAVYQVTDLTSEKVVNLDYAFSTNDTGAIIDYLALFGPNMPPKLSFIIAALYNEKLFGGVGDPGCVDPNRGRQSANTIPPSLFQFAVIVSGLYAGPQSEAEQLLAPLLQNATLIKQNISVVPENKLVYAATFGSQGNSTIACSGKGVNRSIFGGAINTYDKATYVDFLKAFGDLVTTNTDLRGSVFFIEHFSNYQVQKIPDHTSAYPWRDITAHLLFNYAWNDPANQQLMLYSARKLPRLRALKKEWDPENVFRFHHPISMS", "function": "FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of fumigermin that inhibits germination of spores of the inducing S.rapamycinicus, and thus helps the fungus to defend resources in the shared habitat against a bacterial competitor. The partially reducing polyketide synthase fngA alone is sufficient for the production of fumigermin. FgnA catalyzes the condensation of 3 malonyl-CoA units to an acetyl-CoA starter, and 3 methylations to yield fumigermin. It is remarkable that the five cluster genes including fgnA are conserved in distantly related fungi, supporting the assumption of a fumigermin cluster; it is thus possible that originally all five genes were functional, but that the genes encoding tailoring enzymes became inactive from mutations, similar to the case of the fgnA gene in strains A1163 and Af293 (Probable).", "AFDB_id": "AF-Q4WKX2-F1-model_v4" }, { "swissprot_id": "Q9M8T6", "sequence": "MSVKARRISGRLETVVTKVNYAFDPVDDDKIIRNRLLTRTTTTRGEPPLKKLQKKFTSFVLEVDKEEENYNDCGRLAKAFLQELSTFEIPLLKSQAVVEANLREKESFNEVKDETERQIMQAKAEIEDLKKQLEESKIDRQHKEECETIRKLISAQPPRSETEKVIYELNKEIAELEAESTASWRLLELRKKQFALLMHVVDELQNTMEDEQKSLVDEIRSASEDQRNITDAMSVD", "function": "Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export.", "AFDB_id": "AF-Q9M8T6-F1-model_v4" }, { "swissprot_id": "P39127", "sequence": "MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEISCKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIADTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCLYKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTMKVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYENKKEKKFLDFLSHFHF", "function": "Negative regulatory protein for the citA gene for citrate synthase I.", "AFDB_id": "AF-P39127-F1-model_v4" }, { "swissprot_id": "Q9XII1", "sequence": "MEDEEGIGLILARATELRLKISDCIDNSSTTVSDNGDGNEDLSPGEGRKSEIIGNQDKDFDSISSEDVDEAEAERLLRIRDALEALESQLASLQNLRQRQQYEKQLALSEIDYSRKMLLEKLKEYKGKDFEVLRETTTFAGERVDYENDLLLPPYPVHPPLSLGLDNNNGYLSHLPSKKKSDANGFGSGHVRNEAEAKSPNGGSGGSSHGVIRFLGSVAKIVLPIIGVISLLSASGYGPEMRKRGASLNLFGLLPHRATRGKRTPNQCPPGKVLVIEDGEARCLVKERVEIPFDSVVAKRDVTYGYG", "function": "Component of the plastid division machinery consisting in a binary fission accomplished by the simultaneous constriction of the FtsZ ring on the stromal side of the inner envelope membrane, and the ARC5/DRP5B ring on the cytosolic side of the outer envelope membrane. Positive factor of chloroplast division required, with a dosage effect, to mediate the recruitment and dimerization of ARC5/DRP5B at the midplastid constriction site in the cytoplasm at plastid outer envelope membranes (OEMs). Prevents ARC5/DRP5B GTPase acrivity. Relays plastid division site position between stroma and outer surface via interactions with the cytoplasmic ARC5/DRP5B and the inner membrane ARC6 that recruits stromal FtsZ ring. Binding to phosphatidylinositol 4-phosphate (PI4P) modulates negatively chloroplast division.", "AFDB_id": "AF-Q9XII1-F1-model_v4" }, { "swissprot_id": "A0A024F8Y4", "sequence": "MEVKKLEFIGPRVMPGGQKEMDYFCQVPEFQQRCQSGNAVVIPRRDQVADGRGSTGKLFSQTLNTADTIPHCIVMFEDTYTAQSSTQPWLPISTCSVFYQLGEGVCGFGNICHGGIQTTLLDDVMGVLGVLNARLQDGIIPSKVPGAYWPRNNPGMVDLTKSLFATQGIEVKFLRPLRTPQVIEVSAQLVDMDVSGGSFTVQCVIRDMKGKQYAVANANWVIHTPRPRSRL", "function": "Part of the gene cluster that mediates the biosynthesis of verlamelin, a lipopeptide that exhibits antifungal activity against plant pathogenic fungi. Verlamelin is a cyclic hexadepsipeptide and is bridged by ester bonding between a 5-hydroxytetradecanoic acid moiety and a carboxyl group on the terminal Val of amide-bonded tetradecanoyl-hexapeptide D-allo-Thr-D-Ala-L-Pro-L-Gln-D-Tyr-L-Val. VlmA and vlmB are altogether regarded as essential components in the biosynthesis of 5-hydroxytetradecanoic acid. VlmA catalyzes the hydroxylation at position C5 of tetradecanoic acid produced in primary metabolism, while the precise function of vlmB still remains to be solved. To be loaded onto the waiting NRPS, 5-hydroxytetradecanoic acid is activated in the form of acyladenylate by the AMP-dependent ligase vlmC. VlmS seems to accept the fatty-acyl intermediate onto the initial module to further elongate amino acid residues by the downstream modules. In addition, in the last module at its C-terminus, vlmS contains a surplus condensation (C) domain that may be involved in cyclization, the last step to form verlamelin.", "AFDB_id": "AF-A0A024F8Y4-F1-model_v4" }, { "swissprot_id": "B0K8F1", "sequence": "MQGIAKIKEKIFEEATEQKNRIIEKAKKEAAEILEKARKQAVQLEAEAEKKAKKVAREEKRKILSIAELEERKRYLEAKQALINEAFVRAENKLLNLEPEKYRDLVYRMILAAAVDGNEEIIVSEADKEKITPELLERVNEALKKQGKAGNIRFSGEKRAIKGGFILKSATVEINCTFDYLLKVQREELETEVARILFEE", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-B0K8F1-F1-model_v4" }, { "swissprot_id": "Q9AA09", "sequence": "MTFTVLVSVRAKRDFNRLIVWLVERDPRAAARLGPLLEAALDSLTEAPSRGRSVGPTTREISIPFGQSAYVIRYRLLGSSVHVTRIWHGLEQR", "function": "Toxic component of a type II toxin-antitoxin (TA) system. Its toxic effect is neutralized by coexpression with cognate antitoxin RelB1 but no other ParD or RelB antitoxin.", "AFDB_id": "AF-Q9AA09-F1-model_v4" }, { "swissprot_id": "Q641K5", "sequence": "MEGAAVSAAGDGPAVETGLPGSPLEAVAGATAAPVEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALPDSESPLLARIIDWHHRSTGLQAEAEAKMKGLAKPGASEVVLERQRSLKKSKKENDFPQSGQDSVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGIVSPALPSPFKMEQDLCRTAIPLPSSPEADMSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVVISGGLSSPPPDPARGTSHSLSCRRKGILKHSSRYSDGGTDPALTRPEMPTLESLSPPGVPSDGISRSYSRPSSIISDDSVLSSDSFDLLELQENRPARQRIRSCVSAENFLQLQDFETPHNRPRPQYLKRLADSSFSLLTDMDDVTQVYKKALEICSKLN", "function": "Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair.", "AFDB_id": "AF-Q641K5-F1-model_v4" }, { "swissprot_id": "P54746", "sequence": "MKAVSRVHITPHMHWDREWYFTTEESRILLVNNMEEILCRLEQDNEYKYYVLDGQTAILEDYFAVKPENKDRVKKQVEAGKLIIGPWYTQTDTTIVSAESIVRNLMYGMRDCLAFGEPMKIGYLPDSFGMSGQLPHIYNGFGITRTMFWRGCSERHGTDKTEFLWQSSDGSEVTAQVLPLGYAIGKYLPADENGLRKRLDSYFDVLEKASVTKEILLPNGHDQMPLQQNIFEVMDKLREIYPQRKFVMSRFEEVFEKIEAQRDNLATLKGEFIDGKYMRVHRTIGSTRMDIKIAHARIENKIVNLLEPLATLAWTLGFEYHHGLLEKMWKEILKNHAHDSIGCCCSDKVHREIVARFELAEDMADNLIRFYMRKIADNMPQSDADKLVLFNLMPWPREEVINTTVRLRASQFNLRDDRGQPVPYFIRHAREIDPGLIDRQIVHYGNYDPFMEFDIQINQIVPSMGYRTLYIEANQPGNVIAAKSDAEGILENAFWQIALNEDGSLQLVDKDSGVRYDRVLQIEESSDDGDEYDYSPAKEEWVITAANAKPQCDIIHEAWQSRAVIRYDMAVPLNLSERSARQSTGRVGVVLVVTLSHNSRRIDVDINLDNQADDHRLRVLVPTPFNTDSVLADTQFGSLTRPVNDSAMNNWQQEGWKEAPVPVWNMLNYVALQEGRNGMAVFSEGLREFEVIGEEKKTFAITLLRGVGLLGKEDLLLRPGRPSGIKMPVPDSQLRGLLSCRLSLLSYTGTPTAAGVAQQARAWLTPVQCYNKIPWDVMKLNKAGFNVPESYSLLKMPPVGCLISALKKAEDRQEVILRLFNPAESATCDATVAFSREVISCSETMMDEHITTEENQGSNLSGPFLPGQSRTFSYRLA", "function": "May hydrolyze 6-phospho-mannosyl-D-glycerate to mannose-6-phosphate and glycerate.", "AFDB_id": "AF-P54746-F1-model_v4" }, { "swissprot_id": "B0R756", "sequence": "MSQEIAVIGSPAFTTGFQLAGVRKVENVADDEKDDDLDAAVEAVLADEDVGIAVMHDDDLAHLSRGVRQSVEASVEPTFVTIGGGASGASGLRDQIKRAIGIDLMDDDDDASAADTEAGD", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-B0R756-F1-model_v4" }, { "swissprot_id": "Q54BX3", "sequence": "MTILSTFTSFSNPPKLNKSSFSSSTGSSLSMGSNSFAWGGGWGGFGGPKGGSFNVDIAGNLIWGVYGFIRGGVGLVKWRGLQKGCKQP", "function": "Chaperone that suppresses aggregation of proteins with long polyglutamine (polyQ) tracts. Acts by promoting degradation of polyQ aggregates by the proteasome.", "AFDB_id": "AF-Q54BX3-F1-model_v4" }, { "swissprot_id": "Q852U6", "sequence": "MTSASELFSTRRSRPGRSDPALESDTSSYRHHSHHHHRRHGVHHHNQRHDSDGCDPLRRPTPRLRRFFHHPIQERSRPIRDVQGTSQYLNTDSTDTETQSSSFVNLNGSERLPGAVLLARDRLFERLRGVSLSSNSRSNRVSLDDQRESSFHSIDGDPIFQLAGLQVTYECNKKPQGLTQDAINCLHRQTFSSAEVKSEMRDCSICLESFTKGDMLISLPCTHSFHSSCLNPWLRACGDCPCCRRAIAKE", "function": "Probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro.", "AFDB_id": "AF-Q852U6-F1-model_v4" }, { "swissprot_id": "P42951", "sequence": "MSNEAYQHDHTVNPHQKIVVNSYDWLQFRDEQDHCKSKNPITHASPGVGSNAQNSDIAEAPQVFHPSYQSLVNVPSESPRPDQTSGSNPAVGLLHNAEDKASGQEEEGSQYEIQYSVFRPLHAYPTKGLAYEQLRRKEEQEQRENFNHLVSDCIEAVETFGRELERIQTGSSGSYFVYGTRADESVPVGVFKPKDEEPYGPFSPKWTKWAHRTFFPCLFGRSCLIPNLGYICESAASLLDRRLETHLVPYTDTASIESFNFYDNRKKWVLGYNLQKKKQKKLGSFQLFLKEYINADEFFHKYPLPGMYSDVKHSFHRKSSGEDINHKPETTRNLTDETEPSKQINSSPISTESEENSKFEWTESSLSQFRLELEKLIILDYIMRNTDRGLDNWMVKLIKLSNNKWRLKLAAIDNGLSFPWKHPDEWRLYPYGWLYLPLQLLAKPFSEQMRSHFLPILTSTNWWEESYQEFLALFSRDQDFNVRMWKKQWAVLKGQAFNVVETLKDPRQGPLELVRRTRCQVIDEKMQVPCCPPPVSIFKNAIDEPIGSYSTSPMVLPSTPSTIPFHAHNQSNSNPVYYDSTLHPFANKTVIAERLQIVNSTPVFTWC", "function": "May play a role in endocytic and/or exocytic pathways.", "AFDB_id": "AF-P42951-F1-model_v4" }, { "swissprot_id": "P35713", "sequence": "MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPPPEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG", "function": "Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development.", "AFDB_id": "AF-P35713-F1-model_v4" }, { "swissprot_id": "Q9SS86", "sequence": "MAGIPDHIQDQHLVEEDQPFDLEDWLPITASRNANWYYSAFHNVTAIVGAGVLGLPYAMSELGWGPGVVVLILSWVITLYTLWQMIEMHEMFEGQRFDRYHELGQAAFGKKLGLYIIVPLQLLVEISVCIVYMVTGGKSLKNVHDLALGDGDKCTKLRIQHFILIFASSQFVLSLLKNFNSISGVSLVAAVMSVSYSTIAWVASLRKGATTGSVEYGYRKRTTSVPLAFLSALGEMAFAYAGHNVVLEIQATIPSTPENPSKRPMWKGAVVAYIIVAFCYFPVALVGFKTFGNSVEESILESLTKPTALVIVANMFVVIHLLGSYQVYAMPVFDMIESVMIRIWHFSPTRVLRFTIRWTFVAATMGIAVGLPYYSALLSFFGGFVFAPTTYFIPCIMWLILKKPKRFSLSWCMNWFCIIFGLVLMIIAPIGGLAKLIYNIQKGTLPNSRCNLPKH", "function": "Amino acid transporter.", "AFDB_id": "AF-Q9SS86-F1-model_v4" }, { "swissprot_id": "P45301", "sequence": "MTLSPLKKLAILLGATIFLQGCVAAVIGGGAVAAKVATDPRTTGTQIDDETLEFKVENAVEKDAQIKAEGRVNAVSYNGRVLLIGQVPNSDVKDTATALAKGVEGVNEVYNELTVSPKISFAQISKDSWLTTQVKSKMFVDGRVKATDVKVISENGEVFLLGNVTQSQANAAADIASKISGVKKVIKVFKYLD", "function": "Plays an important role in maintaining outer membrane integrity.", "AFDB_id": "AF-P45301-F1-model_v4" }, { "swissprot_id": "Q99KG7", "sequence": "MATTTPPETKSAAWWNYFFLYDGSKVKGEGDPTRAGICYFYPPQTLLDQQELLCGQLAGVVRCLWDLSGTPPMLIRMRNLKFAIRADGDYLWALGCGVEISDASCRQFLDQLIGFFHFYMGPVSLAYKSHPQEELSLQWDTSITQVLRSTSESHRIFNALWNLDRTKVEPLLLLKAALILQTCQRSPHVLAGCILYKGLIVNSQLLPSLTAKVLLHQTVPADQRLPGAGAAPQETGAALPPDVQITSVFLSEEEVASLHEFPVEHETRLQGSSVQYPPWDQSSPTQAEDAWASAAIPEPTPHDGACPSGSGADERLPRLEQECAGPTGLCTTACGQGSGLSSRLQKELCLSREELDSSEMHVSEAQEAFPPLPALGDLETLHSSHSAPTLPEDTAICSCLHPCPLERLPESGRLGQLADLPLTNGQTQVPGTDPLPSSMPVALPPQHPVGVEPSVEPYGNGAQESHSALPRSSRSPDSPGPSPSADRTGFKPSPSGRHAGLVPMNLYTHSVNGLVLSLLAEETLLSDTAAIEEVYHSSLASLNGLEVHLKETLPRDEASLTSSTYNFLHYDRIQSVLSANLPLVTAPQDRRFLQAVNLMHSDFALLPMLYEMTIRNASTAVYACSSPAQETYFQQLAPTARSSGFPNPQDCAFSLAGKAKQKLLKHGVNLL", "function": "Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.", "AFDB_id": "AF-Q99KG7-F1-model_v4" }, { "swissprot_id": "O95715", "sequence": "MSLLPRRAPPVSMRLLAAALLLLLLALYTARVDGSKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKMVIITTKSVSRYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE", "function": "Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.", "AFDB_id": "AF-O95715-F1-model_v4" }, { "swissprot_id": "B5ZBS5", "sequence": "MILSKEKINNYAAYLYIKVAYDEAHNKMAHTVYFTNFYRSSKPLFLDEEDPINPCFQTISMGGGYVSGEVYRSDFEVEANARCIITTQSSAKAYKAVDGKTSEQHTNITLGKNSILEYISDNVIVYEDGKFAQFNNFKMDSTATLIYTECFGPGWSPHGSAYQYEKMYLNTKIYYDNKLVLFDNLKFQPRKNDESAFGIMDGYHYCGTMIVINQEVVEEDVIKIRDLVKEKYPDMDMIFGVSRMDIPGLGLRVLANTYYHVEKINAVAHDYFRRKLFNKKPLILRKP", "function": "Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.", "AFDB_id": "AF-B5ZBS5-F1-model_v4" }, { "swissprot_id": "B9DFU2", "sequence": "MKTQHQWWEVLDPFLTQHEALIAFLTFAAVVIVIYLYRPSWSVCNVPGPTAMPLVGHLPLMAKYGPDVFSVLAKQYGPIFRFQMGRQPLIIIAEAELCREVGIKKFKDLPNRSIPSPISASPLHKKGLFFTRDKRWSKMRNTILSLYQPSHLTSLIPTMHSFITSATHNLDSKPRDIVFSNLFLKLTTDIIGQAAFGVDFGLSGKKPIKDVEVTDFINQHVYSTTQLKMDLSGSLSIILGLLIPILQEPFRQVLKRIPGTMDWRVEKTNARLSGQLNEIVSKRAKEAETDSKDFLSLILKARESDPFAKNIFTSDYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEIDGFGNRDLIPTAHDLQHKFPYLDQVIKEAMRFYMVSPLVARETAKEVEIGGYLLPKGTWVWLALGVLAKDPKNFPEPEKFKPERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLDYGIILSFKNGVKLRTIKRF", "function": "Converts carlactone to carlactonoic acid by catalyzing consecutive oxidations at C-19 to convert the C-19 methyl group into carboxylic acid. Prefers 11R-carlactone to 11S-carlactone as substrate. Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.", "AFDB_id": "AF-B9DFU2-F1-model_v4" }, { "swissprot_id": "P49978", "sequence": "MGFMDFLAKMGENLPAVSKPKDKPTLTRKLLWTFIGLIVYLLMASIPLYGVTSSNSFLSNFLAQQIIFASSQGTLAQLGIGPVITSGLIMQILVGSKLINVDLTTQEGKSKFTQAEKALALIFIIVESSLFGYVFTRATSNILLPIIVVVQLIIASYIILLLDEMIQKGWGLGSGVSLFIMAGIMKVIFWNMFGIVSVQSQNLPVGFFPLLVSYITSGRNLQEIVLNTSSTTPYQPDLIGLIATVGLTILIVYLVNTNIYIPVTTQRLRGIRTTVPLNFLYVSSIPVIFVSVLGADIQLFASLANSISNSASGILTDIANAFFFPPQGVPHSVYALVVDPVGAAIYAAVFIVLSIVFGMLWIDVAGLDPKTQAEQMIRSGIEIPGMRTNPRIIEGILSKYIYALGFFSSLIVGLIAVVATFLGTYGTGVGLLLAITIAMQYYNLLAYERTLEMYPLLKRIVGE", "function": "The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.", "AFDB_id": "AF-P49978-F1-model_v4" }, { "swissprot_id": "P19881", "sequence": "MTAQQGVPIKITNKEIAQEFLDKYDTFLFDCDGVLWLGSQALPYTLEILNLLKQLGKQLIFVTNNSTKSRLAYTKKFASFGIDVKEEQIFTSGYASAVYIRDFLKLQPGKDKVWVFGESGIGEELKLMGYESLGGADSRLDTPFDAAKSPFLVNGLDKDVSCVIAGLDTKVNYHRLAVTLQYLQKDSVHFVGTNVDSTFPQKGYTFPGAGSMIESLAFSSNRRPSYCGKPNQNMLNSIISAFNLDRSKCCMVGDRLNTDMKFGVEGGLGGTLLVLSGIETEERALKISHDYPRPKFYIDKLGDIYTLTNNEL", "function": "PHO13 is dispensable for vegetative growth and sporulation.", "AFDB_id": "AF-P19881-F1-model_v4" }, { "swissprot_id": "Q4JCD8", "sequence": "MKPPVILINYKAYENSYGKKSIEITKKIEKVSKEYGTEIIVSVPATMIHRISEESELTVFAQHVDSGEQGARTGAILPEMIKDAGARGSLLNHSERRIRLDEMAESLERIRVLNLESVVCVDRYELVLPVALLRPNAVLIEPPELIGTGIPVSKAKPEAITKAVEEIKKTKDVYLLAGAGITTGEDVFKAIELGADGIGAASAVMKAKEPEKVVEDFVKNAIKAMEKRGE", "function": "Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).", "AFDB_id": "AF-Q4JCD8-F1-model_v4" }, { "swissprot_id": "A1D6Y7", "sequence": "MAQTNGDMEHSKGWSGHFADFSTAQFRRPRSVCSSDETNGSFFLLQRLPKPNQSNSPPMVNRLKDSRKRRAAVVCRIRDTRDGWFSALVLSSLTSSVIGLFQISVKLPHEPYKIQVMVSSQEQVQDVRQSIVELPGTFQYTCFHLEFNGKRINDFVELSEVEGLKADSEIVLVEDPYTEKEARMHMVRIRDLVGAAGDRSDNLHGLNAGLSLHDAVTAEAAADDVKEHSLSKYDITASPSLETILPRVEAPLPKTVKSISLSAWNPPPYHLRQKGHLLYLQVTTNEGEQFQITSHVSGFYVNKCSNHKFDPLPRTTPKKVSAHSLLTLISKLSPSFNSAFEALQESNNKKDLLTTFPFQNAIPNSPWLVTPPSSNPNSHQADITRSQESYLVSGVDNAETLRDWNEEFQTTRELPRETVQDRVFRERLTSKLFADYNEAAARGAVLVARGEVAPLNPTEDRDAQIFVYNNIFYSFGADGVGTFVSEGGDEAARVAVGKDVLGIKAVNQLDINGLFTPGTVVVDYLGKRIVGQSIVPGIFKQREPGEHQIDYGGVEGKDVVATHPDFVSVFEKMSKALRIKKHPVWDKEGKRHELEGSVETKGLLGTDGRKYVLDLYRVTPLDVTWQEEPGSEDYPHRMSVLRLELVEAYWRSKMSQYVKAEVERRRAAKAQEEAANKEQSSEVTESKEQESEEKAEEALDQERVDISGFQLALNPDVCSGQVPQTEEEKKQWAEDEKEVRDACEFLRSKVIPELIQDLHDGDVGFPMDGQSLSQLLHKRGINIRYLGKLAQLSKEKGSRLEALTTLLVQEMIARAFKHIANRYLRNVPAPFVASCVAHLLNCLLGADVNPNPSAEIDASLREIYPEGDFSFEKVTPETLRAEVEKQVTVRYRYTLEAEWFASLRHLQVLRDIAIKLGLQLGARDYAFTKAQLPAKVPVANGVNGASHDEGKKKKKKGGDSKSPSRAVVEEKPVISIVPDDIVNVVPLVKDASPRSSLAEEALEAGRISLMQNQKQLGQELILESLSLHEQIYGILHPEVAKLYHQLSMLYYQTDEKEAAVELARKAVIVTERTLGVDSADTILAYLNLSLFEHASGNTKAALVYIKHAMDLWKIIYGSNHPDSITTMNNAAVMLQHLKQYSDSRKWFEASLAVCESLFGKQSINTATILFQLAQALALDQDSKGAVGKMRDAYNIFLNQLGPNDRNTKEAETWLEQLTQNAVSIAKHAKDIQARRLRRINMNPRVTTLGTKVQPQVGQTAPEASGAKGAANASMDSRSIDELLKFIEGGDATSSRSKQKKRAAASNPKLRGSKKSSA", "function": "mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.", "AFDB_id": "AF-A1D6Y7-F1-model_v4" }, { "swissprot_id": "P0A1G0", "sequence": "MIRIEILFDRQSTKNLKSGTLQALQNEIEQRLKPHYPEIWLRIDQGSAPSVSVTGARNDKDKERILSLLEEIWQDDSWLPAA", "function": "The imp operon is involved in UV protection and mutation, however the ImpC protein is not essential for these functions.", "AFDB_id": "AF-P0A1G0-F1-model_v4" }, { "swissprot_id": "E9QA28", "sequence": "MKMPLTWYSWFLLSAWILNTGAEISITPEPAQPAEGDNVTLVVHGLSGELLAYNWYAGPTLSLTFLVASYIVSTGDETPGPAHTGREAVRPDGSLDIHGALPGHTGTYILQTLNRQFQTEVGYGHMQVYEILAPPTVMANDTALVERRDTLRLVCSSPSPAEVRWFFNGDALPVAVRLGMSPDGRMLTRHGVRREEAGAYQCEVWNPVSVSRSEPLNLTVYFGPERVAILQDSTTRTGCTIKVDFNMSLTLWCVARSCPEPEYVWAFNGKALKNGQDHLNISSMTAAHEGTYTCIAKNSKTLLSGSASVVVKLSAAAVAMMIVPVPTKPTEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGNWIAGPAHTGREVGFANCSLLVQKLNLTDAGRYTLKTVTLQGKTDTLEVELQVAPLE", "function": "Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.", "AFDB_id": "AF-E9QA28-F1-model_v4" }, { "swissprot_id": "Q6L589", "sequence": "MEGVDVKAPRPGCGGDDGGAAAASLSARREEEEEGAVVGGEDEQVERFYALLANIRALRGMYSRYNGEEGAAGGDGDGASGRKRARRAEPPWRPAFRMEDFEFEEAAAGAGDDDAACSGRTTKKQRSGGGGHGAAVEKRRTEKEAAAAAAEDDDDEQEGGEVVEGKEEHRPGRRVEAHGPTDQ", "function": "Binds to and represses NPR1/NH1-mediated transcriptional activation of LG2 in vitro.", "AFDB_id": "AF-Q6L589-F1-model_v4" }, { "swissprot_id": "B0BN49", "sequence": "MNPLTKVKLINELNEREVQLGVAEKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTVLAVDNFNGIKIKGRTIRVDHVANYRAPQESEDVDDVTRELQEKGCGAKTPPSSPPEVSEDEDAKVTKKPKKDKKEKKKKKEKEKTERPVQAELPSCSRSKTVKETDEQSAKKHSSKPSERAQKSECRERKKSHSGSPDGRTSCRGRAEEPEWEAKKEKHKHEHKPSSRREGEEKSRDKDRGRSSGTHSSRHHGHSEGRSHRSRSRSRSRSPDRSHRHKKHRYSHERESFHASDRRHY", "function": "Involved in pre-mRNA splicing as component of the activated spliceosome.", "AFDB_id": "AF-B0BN49-F1-model_v4" }, { "swissprot_id": "Q8UGK1", "sequence": "MMDIMTDHENPAVTGEDNALPTRSGFVALIGPTNAGKSTLVNRLVGAKVSIVSHKVQTTRAVMRGIAIHKNAQIVFMDTPGIFKPRRRLDRAMVTSAWGGAKDADLILLLIDSERGLKGDAEAILEGLKDVPQKKILCLNKIDQVKREDLLKLAAAANEKVAFDRTFMISATNGSGCEDLMDYLVETLPEGPWYYPEDQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGSVRIEQVIYVERDSQKKIALGKNGDAIKAISTASRKELSEILEQPVHLFLFVKVRENWGDDPERFREMGLEFPRG", "function": "An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.", "AFDB_id": "AF-Q8UGK1-F1-model_v4" }, { "swissprot_id": "Q6DEL1", "sequence": "MSRPDRAINSEAGDWGYSEDAGERAWLLQSPSVDSVQPPSQSDDSRGGTSSLGAVFIVVNAALGAGLLNFPAAFNMAGGITAGVTLQMCMMAFIITGLVILAYCSQVSNESTYQEVVRAVCGKALGVICELAIAVYTFGTCIAFLIIIGDQLDKLIGAINNESEKEISLHWYTDRKFTITLTSVLIILPLSIPKEIGFQKYASTLSVIGTWYVTIIVIVKYIWPSKDVSPGIIPVRPASWTDVFNAMPTICFGFQCHVSSVPVFNSMKKPEIRPWWGVVTISMIICLFVYTGTGVCGFLSFGSSVSQDVLMSYPSDDVAVAIARAFIIICVVTSYPILHFCGRAVLEGLWLRFKGEEVETDVAKERRRRILQTLVWFCLTLILALFIPDIGRVISLIGGLAACFIFVFPGLCLIQAKLSEHDVRSNSWNAMVAYGVIMVTIGAFIFGQTTTNAIYKDIINNPNSP", "function": "Putative sodium-dependent amino acid/proton antiporter.", "AFDB_id": "AF-Q6DEL1-F1-model_v4" }, { "swissprot_id": "D2E9W9", "sequence": "MESFDIVVVGAGWYGLMAARTYLELAPETNLLIVDDSSTVGGVWSKERIYPSLFAQISHPLFEYSFYPMPKDDISPDGFVSGKTIHNYLTSFTRDHNLLPRLRLNTRVERVRRGPSDAGGWVLDIKEGNPLLCHKLIYATGANSSPIIPTWPRQTFEQPVIHSLDLGKHQDYIAKSVETATVVGRSKSSYDAVYHLLCEGKRVNWVMRDGLSGPFSLYAPTFMGLWNIADHISTRFASSFSPCIMNTSGFCYNFLQRNAVGRTLTNVYWRAANYLSVSHAEYWRTPNAEKLRPRPYSDGVFWGSGGIGIATAPDFWKVFHRGNITIHSTEIDSLSHGDVVNLKNGYSLATDIVIHCTGFDKGYTTFDPELREELGLQYNSKSISRWSLLDAKAEQTVDELLPYLRTAPLQDMDPDASSRPEQGPNRHFRRLVVPELAARGDRSILFPGHIHSAFTPLAAELQALWGVSWMLGWRELPPQEEMELEAATFNAWTRKRYLEQGKKHSYFIYDYIPYIDTLMRDLGLNPYRKSSVFEEWFVRYKPSDYGTILDEYRDIRRLSLECLQGTGGFAERTNGHGVNMK", "function": "FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis. The reducing polyketide synthase DEP5 is the central enzyme in depudecin biosynthesis by yielding the backbone polyketide chain. The monooxygenases DEP2 and DEP4, as well as the uncharacterized protein DEP1, then act as tailoring enzymes to modify the intermediate polyketide chain into depudecin.", "AFDB_id": "AF-D2E9W9-F1-model_v4" }, { "swissprot_id": "Q4PC17", "sequence": "MSRLIVRGLPSYLTDARLREHFSQKGAVTDVKLMRRPDGTSRKFGFVGYRSEQEAQQALDYFNRTFIDTSRISIELAKKIGDEELVHQREERRNRRNAGAGPEGSASTSDARKRKADKSDTQQEEGSGKKKPKKGGAISFEEFMSVMQPKAKRKAWQNEDALPEQTMQDIVAPEEAIQKKAARKALKKADAAAAATATAESTAAQPDSGREETPEPDAAANDVGLTDEEYMRLRMKHRVGTDLDTLEQSSSGPEFEQSDNEKDDDDAAADSDPESEDEPIHDQGFECKQAEMQRKAQQAAEKDQKLVDQIMESGRLFIRNLPFAASGDEILAFFESFGTVKQVHIPLDKQTKASKGLAFVSFSDPAHALAAYRAKDGSTFQGRLLHLLPAVNKDALAETGSKKTATLKQARAEQKKQDATKDFNWSMLYMSSDAVASSIADRLGVNKSDILNPGANGGADNAAVRLALAETRIIQETKEFLAQQGINVDAFQGAKGPRSDTTILVKNIPYGTSAEEVEKLFGEHGEVDKVLIPPSGTIAVVEMPVVNEARLAFRAIAYKRFKGGILYLEKAPVGLLTQHKVGEKVVKQAPIVGKSIDSSNPSVDLDGPAGAGAGDEAVDGATLYVKNLSFSTTDERLTAFFHGLSDFAFARIQTKPDPRRPGARLSMGYGFVGFKSIDAARTAQKAMDGKVLDAHTLVVTFARRNAEASTTSISSGGSTKILIKNLPFEATKRDIRDLFSSQGQLKSVRLPKKFDNTTRGFGFVEYSTVREAQSAMEALKHTHLLGRHLVLQWSHLASSTQQQVDMQRSKTKQHFVNTHDNAARADPSKRAKIKLNSAQISEAIKQAKRQRDDVDDDE", "function": "Involved in pre-rRNA processing.", "AFDB_id": "AF-Q4PC17-F1-model_v4" }, { "swissprot_id": "B2KEW8", "sequence": "MNALLTPDYGLIFWTIVNFLLLVFLLGKFAWKPIIGALEARENKISQDKKDAQEARDEAQKIKAELDVRLSNISKEAQEKLAQVEALAKQQKDAMIKDAQASSERMIATAKEEIEAQKNQALKEVKKEIADMAVEAAAKIAGVKTDPKTDAALVDNIVKDIINKA", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-B2KEW8-F1-model_v4" }, { "swissprot_id": "Q08280", "sequence": "MDASSVPPKVDDYGMYTTEISHHNPIELKNLLSSSDSRRNSQDEDSLPNNTNLIKEIDWQGEKVKTYPLNYQTVPLVKLQVIACLIMFVVFGMNDQTVGALLPTLIEYYHISRVDVSNVFIVQLCGYVMASLSKERLNKHFGMRGGMLLAAGLCIVFLIILATAPSSFYVCMFCGLPLGLGIGILDSTGNVLMGSLLVHKNELMGIMHGLYGAAAMVTPPLVSYFVEWGHWSLFFLIPLFFSIIGMIVIFPAFKFETASKYDYLCSVENKESNNDVEEAGDNSLMESTKASPGFFELLRNPAIFLYSLYLFLYLGAEITTGSWFFSYLLETKSSNKVAMSYIAASFWTGLTVGRLCLGFVTERFFENEYKASKAYAFLTLSSYTLFVLVGLINSSSVFYFVVLFFVVFCCGTFIGPLFPNASIVALQVLPKRLHVSGVGVAVAVGGCGGAAIPYLAGVIAHTVGIQYIPLLCWIMVALFTLEWTLYPKFIKGHEEYF", "function": "Probable transporter.", "AFDB_id": "AF-Q08280-F1-model_v4" }, { "swissprot_id": "P75426", "sequence": "MTSPTSLDQLKQQIKIAPIVEHYAIKLKKKGKDFVALCPFHADQNPSMTVSVAKNIFKCFSCQVGGDGIAFIQKIDQVDWKTALNKALSILNLDSQYAVNFYLKEVDPKLKRYWDLHSALVDYYQTRLKLEPKEQGLTYLTETRKLSPQVIERFQLGLAFTLEDQYFLPSLLNYPWISPAIEKAELCFATEKFPEALGFFNQQTHYATFKSRIMIPIHDLKGNPVGFSGRALQKTEKIKYKNSAEHQWFKKSELLFNFHRIDKNTLKLYLVEGYFDVFALTSAGIGDVVGLMGLALSESHIIAFQQQLKALETVVLALDNDTAGHDATFKLLQELNAHGIIVEVVDWNQAAYKDWDELFLAEGSDAVKAKTHRVLNLVEYLVAYFKTKGFDERITVNKVIDIIAQNQKVTADTSFSRFLCQKLQQLLQYSDVETLFTQLQQQKLKVKVNKTTTFTQRAPIYESVVGVVDNSFRNESQPVAITKEFLVENNWKETKERVFHAEIFAYVLLDKQFLVELKQSDLDELFASLQTPLFDVALFIDKARLYWAKVQEPDWAVFNSILGEQQAMFPTTFLAQIKEFFLNKSLSYDPEDYEEDLQFFRQLIVKQKELLKYFKSMVEH", "function": "RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.", "AFDB_id": "AF-P75426-F1-model_v4" }, { "swissprot_id": "Q54QQ1", "sequence": "MDDQQPLQTYNQPPPPLPKHIQLQIQQRQLQLQQQEEQERLQQQQQQQQQQQDQQQHKLEEGSRRRSLSDVVGGVNISNKETPKRAFRIYWANDNHMYWTLLLDSTNTVGDVSEGLKDKVPSSGTQCYLYKRTKANFGRWKDRRLSNEDSVWDIVDRRRKNHKSDPIFVLKRKKSTFSISQKKSPQNESDTSPLSSSGEFLNPYTNPTGSNNIVPSNAGHSRNTSSNSNNSANTSSNNLLAHHQFNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNSSNSNSNNSSNTTTTTTTTTTTTTTSTSTNSINTSNNNNNNNSGSNINPSSFISPMSSLVSLSLSSSPASSAPHSPTLSSQPSSPHTITPITTSPPPPQRNNSSKSLKSTMEMEPPAEYISLLSNNPPPTNGSGSRPPSGSFIPGSIVNGSRSSASDLIGFKPPVCQQQQQQQQQQQQQQQQQVQQQQQQPQQVQQLQQLQQLQQQYQQQQPQQQIQPLSPQQQSQQQQQSPVKQSESIPQSPNLQSITQSSSSNKPLSGSTGMNRSSSPSPFAKKNIGGGGGGGSLADRKNRLSVQPKDIMRLMRFYFGDSLDGTFFTIAVQNDTSAKDVCASVEQKLLLPSGSTFVSLVLPIQPNGSKIERVLGEDEIIIEVKDTWEDPSQTFFQVTHKQQAPNNKRLSRQIQAEPHVIPSEWRRSTDAISLRASSDDMWKRKSIPIFLQVTGPPNTHSHSHSPQRQLPNMSGSPHSHHHHQNNNNNNNNNNNNNNNNDLDDDDSDDESDFDVSTLRGWVHWIPSADLEYIKRIGSGTYSKVYKGKYRDKFVAIKTMRGSNMTTEQIESFKKECDILSTIQSPLLISFYGSCIEESQLSMVVEYCSKGTLHKVLNNPLLDFDWDKWFKWMTEVVEGVRYLHSMNPPMVHRDLKTLNILISSDWTAKLCDFGLTRTMTMTNVSTLGMLRGTMAYTAPEIYDGLLFNTKSDVYSLGVIMWEAIQRCISGVYLRPFHEHPISMDIQIIILTSKNKVRPKISENCPEQLKTLITRCWDENPDKRPNCDEILEILLTMKQAHDENKDEWESIRTKLPKQTIKAVSSSSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNGTNTNSTVNNVVVPSSSNATIVVAPSVSSNSSNINTSMDNKSMSSLSDSPVLPSVGIVSTSSLTGNSNINNNNNNIHDNNNPNNNNSNNSNNTSLDVPPVGVILTRDRRNSIIAVGEVPVIVKPPETPDGTTMVTEVFDFEVPQDSPSLEPLSSNNIISTANILNIGYVNNENNSIIIEGNKSTLNEIGNNNNNNNNNNNNNNNNNNSSNNNSINNNSSNNDENNCINNCINIESNESCIKSNTPEQITLKCVDER", "function": "Serine/threonine kinase regulating cell substrate adhesion, phagocytosis, motility, chemotaxis, and actin cytoskeleton organization. It is a downstream component of Rap1-regulated adhesion, and it is a regulator of myosin II phosphorylation. It is also a negative regulator of development initiation.", "AFDB_id": "AF-Q54QQ1-F1-model_v4" }, { "swissprot_id": "Q6CR76", "sequence": "MSAMENRKNSLHGSPNGLSGLNMVLPREGDSNNGIMTTEDARNGKLKGDKDLNMKMHVGMGTTPINTRLGNTMNSDVANSMSYLLEQPQSGTLIGDRLILETSEEPVGVNLVDGQNARNNQQMLNNASHMDPAFTLPADDTMNNSAAAAAAAAAAAAASTGPSQPTMQSTPSISTGGSTNFQVQIAQRLADIDQRILRMEMLMDNVCNKIDSHSQQQSLWKNDMHQMENKVIDVLDEIKSNIFSLKRQVSNQGDGAFAAELINAISNVSNKHIRKNTYGFPAGNPQGNDMGQTMNGYNNAMQLSSMAAPMSYVPGEQVNLNQLGNSKDQIDRFLTKSANEFMLDPSGLKKRRKNPSSSNESPITLSHTKTHSTSQPINYSASLPNLNLDALSKVMLPQHQQLTHNGGSQHPLSDKSIKFGISSTSHSSSNSSDSDDEEDDIDDEEDEAEDEEDENDDSRDVNDHDNVEGRETLTKKSMKPGNSIEGRDPSGTNGTVNSTTNNHMNTIDTATNTSSQLQGTVIRSTADTENPKQESNASAAATSGAATGVATGTTTANIATSASDKLKLHGDSKKEPKFTMIKAPSSVKEIWREYTQGIDGRPSIKSLDQKFGNKWRANKNKKTYSRRKRMYKFILNGIKKGKSEEEMVQMLENKRIYKDSDGNQKKRTIGWLQQSLSGI", "function": "Required for a complete transcriptional response to osmotic stress.", "AFDB_id": "AF-Q6CR76-F1-model_v4" }, { "swissprot_id": "P24500", "sequence": "MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSFQNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQNQINYQALVERMNGKFNSLKTVLTGGK", "function": "Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.", "AFDB_id": "AF-P24500-F1-model_v4" }, { "swissprot_id": "A0A348B781", "sequence": "MGSISSTPSQKSPVFPARSLLPSDIVAVRPEGDEAKVLKFPDLVKSIPFPLRLNPYIRFVSAESDAFIIEYANFSEKQRNRFIGLNAGLLCGMCYAECGPEQLRVCCDFMSFLFNLDDWSDEFDTAGTKGLEEAVMNTLYHPDTYVSDTVAARTARSWWTRMLKTVGPRCRQRFVETLGFYFKAILQQAADRSSKTIPDLETYISLRRDTSGCKTGFALIEYAAGIDLPNEVVDHPIIQSLLDATNDCVSWANDILSYNREQSRGDTHNLVPVIMQTVGIDRQAAIDYAGDLCNKSVAHFLEGKAALPSWGKEVDVQVEQYVQGLEDWIIANAEWSFMTERYFGKDGPKIRKGLQVSLLPVVGFD", "function": "Terpene cyclase that catalyzes the cyclization of farnesyl diphosphate (FPP) to various sesquiterpenes, including beta-elemene gamma-cadinene, delta-cadinene, and alpha-cadinene.", "AFDB_id": "AF-A0A348B781-F1-model_v4" }, { "swissprot_id": "Q97CC6", "sequence": "MKYSLKTVMSLVDHSGLKPYLREDEIARLIGEASEMGNYSVCIEPIYGNFAVEYIKEKGYSLKVDVTLDFPFGSLPTSARKKIIEDSVYADEIDMVIPIGYVKSHRWDKVEQDINDVVSTARDLGLVSKIITEDGYLTLDEKLKTYDIVIRSAPDFIKTSTGFADKEFCKSLGNETGATPENVKLMSEIAKKIGSNIGIKAAGGIHTYDQVEKIIDSAGMIPEPSNIRLGMSGTKKLYEEMKKASVQQS", "function": "Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.", "AFDB_id": "AF-Q97CC6-F1-model_v4" }, { "swissprot_id": "Q2QUS0", "sequence": "MGNILKCFISCFDGEDEDGGSGHGRFPNSYPPVSSLHYQPLHLDDLQVPLSPPPPSTRQQQPPPRPALSRLHYQPLRLADLQVPLSPPPPSTRQQQLPPRPARPLGYHHGVLWPTIEITPCDDFLNLEFTTKVCEGPQHHSTPSRKTDLNRCIHEKDDGNSKPSYYWLTKNKDNHVVTPQTKRSPRPPSGVAALERDLVDFTRTFEVPEGLAQHVTSPMQAQVTWYRKLLAAYKDIKYPPKESADAAVLVAATLRGIERTNLEGILAFYGFPIPTISKEASENHPSSIPKGVLFVLKTLPVNAKCIVDGDGFTAYVDTLDPIELRQDCNASCQSRNSKKQKLWDKTAADLQISLENTGQKKMFFGGREILARKYEIRLRGIDAPEIGMQYGKESQDALVKLIARKCVTLHVYGQDQFKRFVCDIHCGGVFIQEQMLVNGHAWHFKNYDKRPQFAKWEKMARDARQGLWAYDNLEKPWEWRKNKRKASRHHNSDVR", "function": "Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond.", "AFDB_id": "AF-Q2QUS0-F1-model_v4" }, { "swissprot_id": "Q9V853", "sequence": "MNKLDYPRRNGTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGDAITITVWNQRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation.", "AFDB_id": "AF-Q9V853-F1-model_v4" }, { "swissprot_id": "P40371", "sequence": "MKGSHPNAGSLLEPLHKLNPFSENSTSGHRKNASDHSADGETRPIAIEMKDSKGNTVPVGNSRPSKASNWLAGLMEDKNQRWRRSMEDTHICLYDFGGNQDDGFVAVYDGHAGIQASDYCQKNLHKVLLEKVRNEPDRLVTDLMDETFVEVNSKIAKATHNDICGCTAAVAFFRYEKNRTRRVLYTANAGDARIVLCRDGKAIRLSYDHKGSDANESRRVTQLGGLMVQNRINGVLAVTRALGDTYLKELVSAHPFTTETRIWNGHDEFFIIACDGLWDVVSDQEAVDFVRNFVSPREAAVRLVEFALKRLSTDNITCIVVNLTRNPGDLDDSGLTADNDSYSNDYY", "function": "It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability.", "AFDB_id": "AF-P40371-F1-model_v4" }, { "swissprot_id": "O94379", "sequence": "MALLRGNSLAISQKMLSVFQASALPHISLRIFISPPSIANIWNSILLAVPKKKTSYTKKRSRLLSGKALKDKTVNRCPICGSFKLAHHLCSHCFRNIRREFNE", "function": "Component of the large subunit of mitochondrial ribosome.", "AFDB_id": "AF-O94379-F1-model_v4" }, { "swissprot_id": "P9WI74", "sequence": "MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADFGIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPFQHANPAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGHRLGGAGDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVAVREFQRADDERAAQPARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP", "function": "May play a role in the regulation of glucose transport, cell growth and septum formation.", "AFDB_id": "AF-P9WI74-F1-model_v4" }, { "swissprot_id": "Q56148", "sequence": "MTTRMIILNGGSSAGKSGIVRCLQSVLPEPWLAFGVDSLIEAMPLKMQSAEGGIEFDADGGVSIGPEFRALEGAWAEGVVAMARAGARIIIDDVFLGGAAAQERWRSFVGDLDVLWVGVRCDGAVAEGRETARGDRVAGMAAKQAYVVHEGVEYDVEVDTTHKESIECAWAIAAHVVP", "function": "Inactivates chloramphenicol by catalyzing the transfer of the gamma-phosphate of ATP to the antibiotic's C-3' hydroxyl group.", "AFDB_id": "AF-Q56148-F1-model_v4" }, { "swissprot_id": "Q9ZDK4", "sequence": "MRYIMNSLFKILYLNRFVEYLSTNTYILDIVKIVMGVIAIFASSQITIPIKPVAITMHSVILCIIAFTYSPRLSFLTILTFIFIGVMGLPVFCQFSSGINYFLGSAGGYYLGFLIGMPVMSVLKGKLAENYLNVTIICIIGHAIFYLCGIIWLASMIGLKQAIYSGFIIFIPSGLVKILIFSCLFSYIKNLKRK", "function": "Probable biotin transporter.", "AFDB_id": "AF-Q9ZDK4-F1-model_v4" }, { "swissprot_id": "P49309", "sequence": "MLVLDRDADVPMHRQLYEKLRAEILAGHLKADTRLPPTRMMAEDLGVSRNTVITTYDALLAEGYLESRSGSGTWVATLPPDAVTARNSVGRAGAPSLSSRGMRMAAQPRDRTIPDRIAFHPGYPEIKAFPFSTWARLLKRHARYSHEDLYGYHWVTGHPRLKAAIAEYLRASRGVECAPEQVIVVNGTQAALDILARMLVDEGDICWMEEPGYIGAQNSLLSAGAKLVPLPVERDGWSLEDETRPSPRLIFVTPSCQWPLGCLMRMEDRLRLLQIGERHDAWIVEDDYDSEYRFRGRPVPAMQGLDKSGRVIYMGTFAKTLFPSLRIGFIVVPPQLADGFKRVVSNTGHYPSLLLQAALADFISEGYFATHLRRMRRLYAERQKVFVALCRRHLADWLTIDENDAGMQLVARFTRALEDEVLWRAAQGQGVNFSPLSRQFFHSPPQQGAILGYAGIDPKTMREGINSLRSAFLALESSGALPLDRATAAPRGC", "function": "Could play a regulatory role in the transcription of the moc genes for rhizopine catabolism. Could also have an aminotransferase activity.", "AFDB_id": "AF-P49309-F1-model_v4" }, { "swissprot_id": "Q8TFH6", "sequence": "MKQYLNTVISNPRPAQALGINQPFVVFCFITSRALSFVPAIYWCFKCLHLAFVADKFKWLPLTSALWTLVSAYLSFVLANGFLLKWLIHYSIGPTIIRLFSLNVINFSFLSLSVSFITHGDNAYLLPAWIAISCFQTAAYIVQDWITSPIIRTLPFRSSSSSSSNYRHNLDFLEITVFAVVPVGIASFFTMVMLIWQLYKYPDSFLVSA", "function": "Involved in N-glycosylation.", "AFDB_id": "AF-Q8TFH6-F1-model_v4" }, { "swissprot_id": "C5BKM1", "sequence": "MPTLRRLDISEFRNLRSATLQPGEGINLISGENGSGKTSILESISVLAHGRSFRTHKFRRLINNDEKSFTLFGQIFEGTTRNIGLSRASNGDIQIRIDSKAAHTATELAECLPLLVMNSASFQLLEGSGQVRRKFFDWLVFHVKQEFKHYWKLYARCIKQRNSLLRRDKITRSELLPWDQELTKAAQHIESMRSEVFELFQTHFLNEIGQFDFTETLGAELSCTYVSGWSKTGNYNEQLEDQFERDVAAGYTHIGSHKSDVKINLARVPAVEELSRGQQKSVIVALFLAEALVFRTTTGRTPVFLLDDLPAELDEKNLRIVGKALKNLGSQVFATAIDPKSILTGWELVDDESLRMFHVKHGQVELKNDITLRDSFLL", "function": "The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.", "AFDB_id": "AF-C5BKM1-F1-model_v4" }, { "swissprot_id": "P52032", "sequence": "MVSMTTSSSSYGTFSTVVNSSRPNSSATFLVPSLKFSTGISNFANLSNGFSLKSPINPGFLFKSRPFTVQARAAAEKTVHDFTVKDIDGKDVALNKFKGKVMLIVNVASRCGLTSSNYSELSHLYEKYKTQGFEILAFPCNQFGFQEPGSNSEIKQFACTRFKAEFPIFDKVDVNGPSTAPIYEFLKSNAGGFLGGLIKWNFEKFLIDKKGKVVERYPPTTSPFQIEKDIQKLLAA", "function": "Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.", "AFDB_id": "AF-P52032-F1-model_v4" }, { "swissprot_id": "Q755M5", "sequence": "MSLLRTLQMQPRVITVFAEHANVGAASEILGALKTASGPKCKVQVSTMFPTLEQLIYMSEINRTAVAAQVPRLSELLQKPSFSEEFSSPLAQCTQDGVWRSQGGLWVDWEKRLLGADGQSVHELLGSSTMTID", "function": "Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.", "AFDB_id": "AF-Q755M5-F1-model_v4" }, { "swissprot_id": "Q6ZIK0", "sequence": "MAHAAAATGALAPLHPLLRCTSRHLCASASPRAGLCLHHHRRRRRSSRRTKLAVRAMAPTLSSSSTAAAAPPGLKEGIAGLYDESSGVWESIWGEHMHHGFYDAGEAASMSDHRRAQIRMIEESLAFAAVPDDAEKKPKSVVDVGCGIGGSSRYLANKYGAQCYGITLSPVQAERGNALAAEQGLSDKVSFQVGDALEQPFPDGQFDLVWSMESGEHMPDKRQFVSELARVAAPGARIIIVTWCHRNLEPSEESLKPDELNLLKRICDAYYLPDWCSPSDYVKIAESLSLEDIRTADWSENVAPFWPAVIKSALTWKGLTSLLRSGWKTIRGAMVMPLMIEGYKKGLIKFTIITCRKPETTQ", "function": "Involved in the synthesis of tocopherol (vitamin E). Methylates gamma- and delta-tocopherol to form beta- and alpha-tocopherol, respectively.", "AFDB_id": "AF-Q6ZIK0-F1-model_v4" }, { "swissprot_id": "Q9H8K7", "sequence": "METRTEDGGLTRRPTLASSWDVAGGALTHSLLLTRAGLGPGDFDWEELLAPPAPGQDLVILKRNHNNKDENPCFLYLRCGPDGGEEIASIGILSSARNMEVYLGEEYCGTSRGKNVCTVLDDSEHEKIILYKKNLKLESSTHACKIKLLSFGERQCVFISKVVVHMRSVFANSSTSSPALGSRIDLDKVQTIMESMGSKLSPGAQQLMDMVRCQQRNCIPIGEQLQSVLGNSGYKHMIGLQSSSTLGTLNKSSSTPFPFRTGLTSGNVTENLQTYIDKSTQLPGGENSTKLDECKVMPQNHSFLENDLKNAMASFLPKKVSDNSNIPNSELLPFLQNLCSQVNHLHVGNKTECQENITKHGERILGVGMEEQSICSYLEKILSKNMELMEKKLMDYIDQRIHELQEHIDDKIALLLDLLQNPNSPPTGIPLRHYDSGERLSNGER", "function": "ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival.", "AFDB_id": "AF-Q9H8K7-F1-model_v4" }, { "swissprot_id": "Q2FV99", "sequence": "MKKWTNRLMTIAGVVLILVAAYLFAKPHIDNYLHDKDKDEKIEQYDKNVKEQASKDKKQQAKPQIPKDKSKVAGYIEIPDADIKEPVYPGPATPEQLNRGVSFAEENESLDDQNISIAGHTFIDRPNYQFTNLKAAKKGSMVYFKVGNETRKYKMTSIRDVKPTDVGVLDEQKGKDKQLTLITCDDYNEKTGVWEKRKIFVATEVK", "function": "Transpeptidase that anchors surface proteins to the cell wall. Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall. This sortase recognizes a Leu-Pro-x-Thr-Gly (LPXTG) motif, which is cleaved by the sortase between the threonine and glycine residues. Utilizes lipid II as the peptidoglycan substrate for the sorting reaction. Responsible for the display of important virulence factors. Important for interactions with the host and host colonization during infection.", "AFDB_id": "AF-Q2FV99-F1-model_v4" }, { "swissprot_id": "Q10731", "sequence": "MASKNLFVLFFIFALFAANIAALQCPKNSEVRNSPCPRTCNDPYGQNSCITVIRETCHCKGELVFDSDSICVPISQC", "function": "Highly specific for fungal protease and subtilisin.", "AFDB_id": "AF-Q10731-F1-model_v4" }, { "swissprot_id": "P16649", "sequence": "MTASVSNTQNKLNELLDAIRQEFLQVSQEANTYRLQNQKDYDFKMNQQLAEMQQIRNTVYELELTHRKMKDAYEEEIKHLKLGLEQRDHQIASLTVQQQRQQQQQQQVQQHLQQQQQQLAAASASVPVAQQPPATTSATATPAANTTTGSPSAFPVQASRPNLVGSQLPTTTLPVVSSNAQQQLPQQQLQQQQLQQQQPPPQVSVAPLSNTAINGSPTSKETTTLPSVKAPESTLKETEPENNNTSKINDTGSATTATTTTATETEIKPKEEDATPASLHQDHYLVPYNQRANHSKPIPPFLLDLDSQSVPDALKKQTNDYYILYNPALPREIDVELHKSLDHTSVVCCVKFSNDGEYLATGCNKTTQVYRVSDGSLVARLSDDSAANNHRNSITENNTTTSTDNNTMTTTTTTTITTTAMTSAAELAKDVENLNTSSSPSSDLYIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGKYIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKKSGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWKYKKIAPN", "function": "Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.", "AFDB_id": "AF-P16649-F1-model_v4" }, { "swissprot_id": "Q7S931", "sequence": "MSGKKWDEEEEESSAPNSPVLAPGRRRFDDEEGNESDVLDSWDAAEDSEVEREKAKKAAEAKAKAEAEAAANKKSKAQRIAERQAERARQLAEDSDAEEETEAERRERLRREQKESDLKHAEDLFAGIGISNDRKVVSKGTIVQIDPKDPNNTIDISTLALFNPTTKTQFETLRTTLGPMIGKLSPKPHYTLFLQEFSKQLAKDLKSDEIKKIASTLTALSNEKLKEEKAAEKGGKKSKAAKTKTSLAGVGRGGAIAEAHDTYDDDAFGDDDFM", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.", "AFDB_id": "AF-Q7S931-F1-model_v4" }, { "swissprot_id": "Q46336", "sequence": "MMLIECPNCGPRNETEFSYGGQAHVAYPEDPNALSDKEWSRYLFYRENSKGIFAERWVHSGGCRKWFNALRDTATYEFKAVYRAGEPRPELNTQGGSR", "function": "Catalyzes the oxidative demethylation of sarcosine to yield glycine, hydrogen peroxide and 5,10-methylenetetrahydrofolate.", "AFDB_id": "AF-Q46336-F1-model_v4" }, { "swissprot_id": "P0A5A6", "sequence": "MLSVPHLDRDFDYLVPAEHSDDAQPGVRVRVRFHGRLVDGFVLERRSDSDHHGKLGWLDRVVSPEPVLTTEIRRLVDAVAARYAGTRQDVLRLAVPARHARVEREITTAPGRPVVAPVDPSGWAAYGRGRQFLAALADSRAARAVWQALPGELWADRFAEAAAQTVRAGRTVLAIVPDQRDLDTLWQAATALVDEHSVVALSAGLGPEARYRRWLAALRGSARLVIGTRSAVFAPLSELGLVMVWADADDSLAEPRAPYPHAREVAMLRAHQARCAALIGGYARTAEAHALVRSGWAHDVVAPRPEVRARSPRVVALDDSGYDDARDPAARTARLPSIALRAARSALQSGAPVLVQVPRRGYIPSLACGRCRAIARCRSCTGPLSLQGAGSPGAVCRWCGRVDPTLRCVRCGSDVVRAVVVGARRTAEELGRAFPGTAVITSAGDTLVPQLDAGPALVVATPGAEPRAPGGYGAALLLDSWALLGRQDLRAAEDALWRWMTAAALVRPRGAGGVVTVVAESSIPTVQSLIRWDPVGHAEAELAARTEVGLPPSVHIAALDGPAGTVTALLEAARLPDPDRLQADLLGPVDLPPGVRRPAGIPADAPVIRMLLRVCREQGLELAASLRRGIGVLSARQTRQTRSLVRVQIDPLHIG", "function": "Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.", "AFDB_id": "AF-P0A5A6-F1-model_v4" }, { "swissprot_id": "Q6MJR4", "sequence": "MKTRIDLTVEPRETGKHNSRGLRTSRNVPAVIYGAVTPTNVSVGEKEIVKYNTRAYENALFNLKSSDKTANGIVVLIKSVDVHPLTRRPQHVDFFALDLKKAVRVNVEVRLEGKAIGLSEGGLLNVVLRSVEVECLPTEIPEFFTADISNLAVGDALHVSDIKVSGSVKMITGAEQTIAVVNAQEEEVAAAPAAAAAPAAAAPAAKAPAAKK", "function": "This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.", "AFDB_id": "AF-Q6MJR4-F1-model_v4" }, { "swissprot_id": "P08031", "sequence": "MKVLIVALALLALAASAASSTSGGCGCQTPPFHLPPPFYMPPPFYLPPQQQPQPWQYPTQPPQLSPCQQFGSCGVGSVGSPFLGQCVEFLRHQCSPAATPYGSPQCQALQQQCCHQIRQVEPLHRYQATYGVVLQSFLQQQPQGELAALMAAQVAQQLTAMCGLQLQQPGPCPCNAAAGGVYY", "function": "Zeins are major seed storage proteins.", "AFDB_id": "AF-P08031-F1-model_v4" }, { "swissprot_id": "P38204", "sequence": "MDRNVYEACSNIIKEFGTHVVSADEVLAEKIDNAVPIPFKTREEIDADVEKDRNEGVFEGNIIPDIDLRVVHYYATQLCLNKYPHLINAFDETSLITLGLLIEKWVKDYLTSIQTEQGRQSKVIGKGPCEFISKHIDYRHAPGNI", "function": "Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.", "AFDB_id": "AF-P38204-F1-model_v4" }, { "swissprot_id": "P9WJ72", "sequence": "MRYFYDTEFIEDGHTIELISIGVVAEDGREYYAVSTEFDPERAGSWVRTHVLPKLPPPASQLWRSRQQIRLDLEEFLRIDGTDSIELWAWVGAYDHVALCQLWGPMTALPPTVPRFTRELRQLWEDRGCPRMPPRPRDVHDALVDARDQLRRFRLITSTDDAGRGAAR", "function": "Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.", "AFDB_id": "AF-P9WJ72-F1-model_v4" }, { "swissprot_id": "P53032", "sequence": "MSTSITVRNRDRSLPPLLLPNVSLLEKDIRRKGTQNVGITDPELLSTTWTRKRAFPTDELLGGYKRLKPAAADSNECAIGIATVTPPPTLPVSAIVPPPQNYTPPLFEYHPHALASMVNEDANASCTQMSIISRSTSNSTTSSATSTSSISKRQRSGPSCDKCRLKKIKCNAKIEILLQDDTIMPMISNKLRYVLTPDDIRLYRGTLLRNIAIPDDVIEGTGSRKLIKHIDKLVLLTPCLPCIKKKHSSSSTNFPKNDKCTFSKGFTRADINISSKISLKFKDKTIYDITYDDYKSIDF", "function": "Transcription factor involved in the induction of hypoxic gene transcription when the cells are shifted from aerobiosis to anaerobiosis. Involved in sterol uptake.", "AFDB_id": "AF-P53032-F1-model_v4" }, { "swissprot_id": "A9AWD5", "sequence": "MSLIVDILIDDLRALIRDLGQNGGLMSPSVYDTSQALRLYPTPSEEHVWPAVNWLISQQQSDGGWGNPSMPLSRAVPTLAAILALRRHCQRRSTFDGLLEAKRFLRRQLEYWEKPLPDNLPVGMELLLPYMLEEAYREEHQDDIDDVPIKLRLNIPLAPYRELIALGEHKRSLIQQKKPRAGTAPVYSWEAWASHADPELIDGSGGIGHSPAATAAWLFAANHNPNLRNEIAGAENYLRQASLATSESAPCIMPTAWPIPRFEQSFSLYALVTGGILDFPSIQDVLKPQIADLHQALKPRGIGFSDDFMPDGDDTAAAVAVLIAAGYPVDLAILNQFEREPYFVAYHGELQPSISLTARAVHALDLAGVDISRWWKIFIDAQKLDGSWSGDKWNTSWLYTTCHVLIALKNSPYKTAMKEAVAALQVHQHPDGGWGIINRSTTVETAYAVLALQNLREAGLLDDDDIHMLQRGYNWLCIHYRPFRMKEYQCWLNKEIYCPQRIDRAYELSAMLAVTLGELKL", "function": "Involved in the biosynthesis of (+)-O-methylkolavelool. Catalyzes the conversion of geranylgeranyl diphosphate into (+)-kolavenyl diphosphate.", "AFDB_id": "AF-A9AWD5-F1-model_v4" }, { "swissprot_id": "Q9KQS0", "sequence": "MSVRHTIRAMYHMEQSWFSRVGQFTDSIEEFLIAFFMGAMTLLTFANVIMRYLFNDNILWALEGTVFMFAWMVLVGASFGVKRHFHIGVDVLINIAPARLRKLYALVAVACCLAFSILLLIGSWNYWHPFITERAWYETDDIPMPDMLQFLADWVNEGERYEKLPRFIPYAALPIGMALLTFRFLQIAWQIITGKLDRMIAGHEAEEDLEALKAELSEAGEAMMPKTQGKEK", "function": "Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake.", "AFDB_id": "AF-Q9KQS0-F1-model_v4" }, { "swissprot_id": "P09030", "sequence": "MKFVSFNINGLRARPHQLEAIVEKHQPDVIGLQETKVHDDMFPLEEVAKLGYNVFYHGQKGHYGVALLTKETPIAVRRGFPGDDEEAQRRIIMAEIPSLLGNVTVINGYFPQGESRDHPIKFPAKAQFYQNLQNYLETELKRDNPVLIMGDMNISPTDLDIGIGEENRKRWLRTGKCSFLPEEREWMDRLMSWGLVDTFRHANPQTADRFSWFDYRSKGFDDNRGLRIDLLLASQPLAECCVETGIDYEIRSMEKPSDHAPVWATFRR", "function": "Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities.", "AFDB_id": "AF-P09030-F1-model_v4" }, { "swissprot_id": "Q47CF8", "sequence": "MKVETYLFGAVDVSPEKVITFPNGLVGFEQSKRYMLVHEEGPAEPSSFTLQSLDDPMLAFQIVDPVMLGFNYELALSDAENALLQSPSPEDVAVMQVLFRKEQDDKGSITPNLRAPLVINTKSRVGLQKVMETMRPNITLSNLSSSI", "function": "Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.", "AFDB_id": "AF-Q47CF8-F1-model_v4" }, { "swissprot_id": "O23264", "sequence": "MATETEVVAPVTVSNGGSKGCCKYGGPGYATPLAAMSGPSEKLIYVTAVYTGTGIDKPDYLATVDVDPSSPSYSSVIHRLPMPFVGDELHHSGWNSCSSCHGDASVDRRYLVLPSLISGRIYAIDTKENPRAPSLYKYVDPKEIADKTGLAFPHTAHCLATGEILVSCLGDEEGNAKGNGFLLLDSDFNIKNRWEKPGHSPLYGYDFWYQPRHKTMISTSWGAPKAFSKGFNLQHVADGLYGSHLHVYSWPGGEIKQLIDLGPTGLLPLEIRFLHDPSKDTGFVGSALSSNMIRFFKNSDETWSHEVVISVKPLKVENWILPEMPGLITDFLISLDDRFIYFVNWLHGDIRQYNIEDPKNPVLTGQIWVGGLLQKGSPVKAVGEDGNTFQFEVPQIKGKSLRGGPQMIQLSLDGKRLYATNSLFSAWDRQFYPEIMEKGSHIIQIDVDTEKGGLTINPDFFVDFGDEPDGPSLAHEMRYPGGDCTSDIWI", "function": "Binds cadmium and mediates lower sensitivity to stress requiring glutathione (GSH) for tolerance (e.g. cadmium, selenate, and hydrogen peroxide excess). Probably helps to detoxify cadmium potentially through direct binding. Binds selenium, cadmium, zinc and nickel in vitro.", "AFDB_id": "AF-O23264-F1-model_v4" }, { "swissprot_id": "P42073", "sequence": "MSAPVPQLVNISHALQASTIQQIRLDMVDFNKDCKLSSIQLARIDKYIDSLQAALNQFTKDNLHIERKEKNVTEADIQLYSGLKSMYLDYLNQLIKLKHEKQHHSTPPIANDVSLDFFVNQLPKFSPEERKNYIDNLILNKNSHNRLSKMDGLVDAVINLCVLDTSVAENVRSYMKLLDTLGFQKGSNSTGTKANLKKKLASSKAKIKDSEKEKEKEKDKSKVKMKTKLKPSPLLNNDDKNSSPSPTASTSSMKKLKSGLFNKNEAKSTESLPTSSKKKLSFSKYLNKDDADMTKLGTKRSIDVDFKVNPEASTVASNIISSSTSGSSTTTVATPASSEEPLKKKTKISVQDSNVQSILRNGKPKKARISSIKFLDDSQLIKVYGDDLPNQGLQVSPTQLKKILKPFKEGEPKEIILFEDMSIKLKPLDLMFLKNTNSDDYMDISETKGGPIHCETRTPLIYRKNFNHFNPDLNKRPPREPIEFDLNGNTNSTPTIAKAFGKNSLLLRKDRGGLPYKHVPIVKRNKYPPRPVH", "function": "RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Negative regulator of poly(A) synthesis. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. REF2 is required for 3'-end formation of snoRNAs.", "AFDB_id": "AF-P42073-F1-model_v4" }, { "swissprot_id": "Q60326", "sequence": "MRAILILLDGLGDRASEILNNKTPLQFAKTPNLDRLAENGMCGLMTTYKEGIPLGTEVAHFLLWGYSLEEFPGRGVIEALGEDIEIEKNAIYLRASLGFVKKDEKGFLVIDRRTKDISREEIEKLVDSLPTCVDGYKFELFYSFDVHFILKIKERNGWISDKISDSDPFYKNRYVMKVKAIRELCKSEVEYSKAKDTARALNKYLLNVYKILQNHKINRKRRKLEKMPANFLLTKWASRYKRVESFKEKWGMNAVILAESSLFKGLAKFLGMDFIKIESFEEGIDLIPELDYDFIHLHTKETDEAAHTKNPLNKVKVIEKIDKLIGNLKLREDDLLIITADHSTPSVGNLIHSGESVPILFYGKNVRVDNVKEFNEISCSNGHLRIRGEELMHLILNYTDRALLYGLRSGDRLRYYIPKDDEIDLLEG", "function": "Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.", "AFDB_id": "AF-Q60326-F1-model_v4" }, { "swissprot_id": "Q75L84", "sequence": "MGTAAVAAAERPKQRRSSHLWKKALLHFSLCFVMGFFTGFAPSSSSSWRAGSGGGGGVQPRHQLAASHVAVNQQVSLVPDAAAAEAAGVGNGAVVDVGDDEGGEGARRMLIVVTTTRGERRRRRGELLRLAHTLRLVRPPVVWVVVEPAADAAATAEVLRGTGVMYRHLAFRPEENFTTADAEAHAQRNAALAHVEKHRLSGVVHFADAAGVYDAHFFDEIRQIEAFGTWPVATMSAGEKKVVVEGPLCSDSKVVGWFSRDFNDGTTRAVTYNTEADLNPAGAAGTRAHTIDVSGFAFNSSILWDPERWGRPTSLPDTSQDSIKFVQEVVLEDRTKLKGIPSDCSQIMVWQYTMPMQVHAQTSTPKTHNRR", "function": "Probable beta-1,4-xylosyltransferase involved in xylan biosynthesis in cell walls.", "AFDB_id": "AF-Q75L84-F1-model_v4" }, { "swissprot_id": "Q49V10", "sequence": "MASLKSIIRQGKQTRSDLKTLRNTGKVPAIVYGYGTKNTSVKVDEVEFIKVIREVGRNGVIELGVGSKTIKVMVSDYQFDPLKNQITHIDFLAINMTEERTVEVPVQLVGEAVGTKEGGVVEQPLFNLEVTATPDNIPESIEVDISELEINDSLSVEDIKVSGDFTIENEASDSIVTVVPPTEEPTEEEIEAMEGEAATEEPEVVGEEKEDESGEDQKEE", "function": "This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.", "AFDB_id": "AF-Q49V10-F1-model_v4" }, { "swissprot_id": "A2QBB4", "sequence": "MRMPSAISIGVIAGLSVAASAVPSLQKNGTTCTVIPLGNGQDDVPNILSAVDECGQTSGGRVVLPAPYTYRINQRMTTHLTDSRLEIGGTLLFSDDIDYWVNNSYRVDFQNQSSAWRITGHDYVVDGGPRQGGVDGNGQLWYTWAKGGSNVFGRPMPVHVFESTRATLRNLAIRQPQFWAVLVDSSSHINLDNFYVNATNHDSSVSPEGEWVQNTDGIDTYRSDHITVTNWVYQGGDDAVAFKGNSTNIHVENVTVYGGPGIAFGSLGQYPDRTDIVENVTVRNVRVQPSFQRAMNSGVYFKSWIGVNYGVPPNGGGGGHGYVRNVSVENLRLKDVQLPVYIDTCLSYLFSENITQYCDTSTYEFEDLHFRNISGNGLATVTDYPGKNISFAVALLCSEKAPCTDLTFQDISITLPGNYTGKHVLCENAEAEGLPCNS", "function": "Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.", "AFDB_id": "AF-A2QBB4-F1-model_v4" }, { "swissprot_id": "Q20459", "sequence": "MQIYLGITICLVAFLTVIDCAIPYYRTHSNFGSLGRRKVRQVQRDLTYRWPNNTVPYYVGNVTSTIKKSVRLAIEELQAWTCIRFQNVNEKYSDGDSVRIVDLGSCSSPIGRQQIGTQDVSLTKNCWGMGTAIHELMHAIGIEHTQSRSDRNRYLDILAQNIDNRDLPNFELLSPRLWANLVPYDYGSVMHYSADSFSNKDDEQTMLPKDRSFIETMGSMIPNFYDFDQINQYYQCYDSCRNAGQLANCANGGIPNPNNCQVCNCPMGYGGDLCDQRPEGCGSTLVATDRWQKQKLSVRFSRNDDQYFTFCNSWIVGPSDRTLQVIYEITSDSIRRQICSFGCYEGGIEVKHLQDPRITNDRDCCLNTPLNLTTTVNPLPVILYTSGATVTYDFSYRYV", "function": "Metalloprotease.", "AFDB_id": "AF-Q20459-F1-model_v4" }, { "swissprot_id": "Q1PE40", "sequence": "MRRVSWSTVLIVVVMVSLFFVEHVVVPAAAGRVLTEKSGDGSATMTVEKMKSTVDSWFQRLASGPSPRGRGH", "function": "Endogenous secreted peptide that acts as elicitor of immune response and positive regulator of defense response. Amplifies the immune response triggered by flg22, the active epitope of bacterial flagellin. Acts as negative regulator of root growth.", "AFDB_id": "AF-Q1PE40-F1-model_v4" }, { "swissprot_id": "Q03474", "sequence": "MLDMNPQETYTAPEEVNTPSRPIDENALLQRHQVMVKRVVNQLRVHATSHCSIEDMQQIGLIALVEAGRRYGDIDDTHFPAFAVCRVRGAILDELRRLDWRSRKTRQQAHELNDVTRDLTRSLGRMPTDSEIIKALGTDEQDYYNRQNAALAGEMQSLDQLMENSTDSHFGGQYDGMEHEHIRRSLDSALGRLSKRDQLLLTLFYQHELNLHEIALVLDLTPPRICQLHKQALKQLNQLMSS", "function": "Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This alternative sigma factor is specific for the flagellin gene (fliC) expression.", "AFDB_id": "AF-Q03474-F1-model_v4" }, { "swissprot_id": "Q5FRJ7", "sequence": "MSDSFSARLEAAVSALPARFPGPGGAVAVLKDGEVLVRHGWGYANVERRIPFTPSTLFRMCSITKQFTCGTLLDLYDDPSELDADVDARLPQLDEPSPGMLHLAHNQSGLRDYWAVAMLHGAPIEGYFGDREARRVIDGTRTLQFQPGTSYSYVNQNFRLISDILQDRTGRSFAELLQTSIFNPVGMERAILAAETRAMPDGTVGYEGSVESGFRPAINNIWWTGDAGLGASLDDMIAWERFIDETRDAPDSLYRRLTVPVTFSDGQPAPYGFGLQRTKMFGRDVTMHGGALRGWRSHRLHVASERLSVVVMFNHMSAAQVASAQILAAALGVPYEPERSTQQPTALYGTYLERETGLSARIEPAPGGAKLRYLMVPELLEGISATRAEAGSVVVKAQETAEGAEAVMERPGENRTSILARCDETPGEDIAELAGVYRCEELDEAEVTIELAGGVVYGGFSGILGDGRMEMLQRLAKDVWVLPCPRALDHTAPGDWTLAFERQGGSVTAVRVGCWLARDLMYQRV", "function": "Hydrolyzes N-terminal residues in D-amino acid-containing peptides.", "AFDB_id": "AF-Q5FRJ7-F1-model_v4" }, { "swissprot_id": "Q8VY08", "sequence": "MAESRSNRAAVQATNDDASASKLSCVKKGYMKDDYVHLFVKRPVRRSPIINRGYFSRWAAFRKLMSQFLLSGTSSKKQILSLGAGFDTTYFQLLDEGNGPNLYVELDFKEVTSKKAAVIQNSSQLRDKLGANASISIDEGQVLSDHYKLLPVDLRDIPKLRDVISFADMDLSLPTFIIAECVLIYLDPDSSRAIVNWSSKTFSTAVFFLYEQIHPDDAFGHQMIRNLESRGCALLSIDASPTLLAKERLFLDNGWQRAVAWDMLKVYGSFVDTQEKRRIERLELFDEFEEWHMMQEHYCVTYAVNDAMGIFGDFGFTREGGGERMSSSASSP", "function": "Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A (PP2A) catalytic subunits to form alpha-leucine ester residues (Probable). Involved in brassinosteroid (BR) signaling. Plays a negative role in BR signaling pathway. Functions as a positive regulator of BRI1 receptor-kinase degradation. Methylates PP2A, thus facilitating its association with activated BRI1. This leads to receptor dephosphorylation and degradation, and thus to the termination of BR signaling. May act upstream of ASK7/BIN2. Involved in methylation of PP2A during environemental stress responses.", "AFDB_id": "AF-Q8VY08-F1-model_v4" }, { "swissprot_id": "Q9W0Y2", "sequence": "MAEKLRMAARVFVYGTLKRGEPNHHWLTKKENGQARFLGRGKTETKFPLVVGTRYNIPFLLARPGEGNHIEGEVYEVDETMLSKLDILEDYPDYYDREQQTILMEQNETIQCWLYLIRNFPDKMLAKELLISYHNTPERPYNEKSVRTVSARDDLSY", "function": "Putative gamma-glutamylcyclotransferase.", "AFDB_id": "AF-Q9W0Y2-F1-model_v4" }, { "swissprot_id": "P38913", "sequence": "MQLSKAAEMCYEITNSYLHIDQKSQIIASTQEAIRLTRKYLLSEIFVRWSPLNGEISFSYNGGKDCQVLLLLYLSCLWEYFFIKAQNSQFDFEFQSFPMQRLPTVFIDQEETFPTLENFVLETSERYCLSLYESQRQSGASVNMADAFRDFIKIYPETEAIVIGIRHTDPFGEALKPIQRTDSNWPDFMRLQPLLHWDLTNIWSFLLYSNEPICGLYGKGFTSIGGINNSLPNPHLRKDSNNPALHFEWEIIHAFGKDAEGERSSAINTSPISVVDKERFSKYHDNYYPGWYLVDDTLERAGRIKN", "function": "Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.", "AFDB_id": "AF-P38913-F1-model_v4" }, { "swissprot_id": "A2QG68", "sequence": "MAPIALKILLFTSLIVPSISLSDQARNGHARTICEVKPGGSSEIDDVPAIVDALTTCGSGGRVIFSNNTYHINSVMNTTWLDDVEIDLQGTLLWSTNISYWLNHSLPVGYQNQSTAWILGGKDIVFEGHGYGTFNGSGQTWYRYVGSTSNYPRRPNQLTVSGAMGAVFKGLRFVQSQMWTMSIIHTSNSWFDSIYVNNLYDDGGSAQNTDGANTIYSKNITLTNWEVVNGDDSISTKANSTDITIANCTFTSGLGIAIGSIGQYNGAFETVERLKISNITYEKTTHAVYFKTWTGDQVGYPPNGGGGGLGYASDIVATNLKTNNLKGAPFTISQCTTFSGASGNCTNSKFQIRDLVFTDISGTTDSSDVASFQCSAVAPCEDITIENVSLRIAGNTTHAEEYLCGNVDGTVGFNCTGDVCVGSSATGGC", "function": "Alpha-L-rhamnosidase which is able to degrade p-nitrophenyl-alpha-L-rhamnopyranoside (pnp_Rha). The natural substrate of this enzyme has not been identified yet.", "AFDB_id": "AF-A2QG68-F1-model_v4" }, { "swissprot_id": "O94762", "sequence": "MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYFGDALPACAKGCDHCQNPTAVRRRLEALERSSSWSKTCIGPSQGNGFDPELYEGGRKGYGDFSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMQLRKGKDPKIEEFVPPDENCPLKEASSRRIPRLTVKAREHCLRLLEEALSSNRQSTRTADEADLRAKAVELEHETFRNAKVANLYKASVLKKVADIHRASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFPKGSCPFQTATELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGSAHYGGPSPEKKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLASAPEAEGACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTPEVQPTPAKDTWKGKRPRSQQENPESQPQKRPRPSAKPSVVAEVKGSVSASEQGTLNPTAQDPFQLSAPGVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVKEEAQNLIRHFFHGRARCESEADWHGLCGPQR", "function": "DNA helicase that plays an important role in DNA replication, transcription and repair. Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Associates also with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.", "AFDB_id": "AF-O94762-F1-model_v4" }, { "swissprot_id": "P21505", "sequence": "MHNNENVSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITQKSENLIKQHIAPLMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNMREQIAFIKGLYVAEGDKTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHLDDHRHGVYVLNISLRDRIKFVHTILSSHLNPLPPERAGGYT", "function": "Endonuclease involved in intron homing (Probable). Recognizes DNA in the 23S rRNA gene intron (minimally 5'-CCGGGTAAGTTCCGG-3'), cutting after A-8 on the top and C-11 on the bottom strand. Has a slow turnover rate, cuts the coding strand with a slight preference over the non-coding strand.", "AFDB_id": "AF-P21505-F1-model_v4" }, { "swissprot_id": "B3DUG9", "sequence": "MILKLVLYDNPILRKKGMPIDSFDDRLKRLVQDMLETMAYYKGVGLAAQQVGLNLQLAVIDVSGSKLSSSLLIGGKPAMVEEHMPLFLINPTLSYTQSKEISNEGCLSFPGLRIDVPRSKRVKVKTFDLEGRPWYFEAGGFLSVAIQHEFDHLQGKLFIDYLSAEQKKAIKEELEKIKRGEAILSVKETD", "function": "Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.", "AFDB_id": "AF-B3DUG9-F1-model_v4" }, { "swissprot_id": "P36121", "sequence": "MSIDNKLFVTEEDEEDRTQDRADVEDESNDIDMIADENGTNSAIANEQEEKSEEVKAEDDTGEEEEDDPVIEEFPLKISGEEESLHVFQYANRPRLVGRKPAEHPFISAARYKPKSHLWEIDIPLDEQAFYNKDKAESEWNGVNVQTLKGVGVENNGQYAAFVKDMQVYLVPIERVAQLKPFFKYIDDANVTRKQEDARRNPNPSSQRAQVVTMSVKSVNDPSQNRLTGSLLAHKVADEEANIELTWAEGTFEQFKDTIVKEAEDKTLVALEKQEDYIDNLV", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.", "AFDB_id": "AF-P36121-F1-model_v4" }, { "swissprot_id": "F6S215", "sequence": "MAERNSASWNRKVASFCSEPKTFLCDSSVDGFLGELLKDLQSEAIHGQTKILMMDLLLEFPEFLCPDQKTVEMTAETLMNILKKMPSSERSMTLRCHLLLAIETVLITCESFNQNSKMAQDFASLLMHIISDVNDKKQGVANRPLRTTACECLRELESCYPGFLSQRMEKLYLMQQQEVTAAHQSYTLLYTVVLKNAIRFLAQKEGPSNGALKNALLSNEDFFWSATENMVELQPSSNEQLLLLPSNSETKDLKSILALLLEDSYLLTPVCQNTLFWQIVQVVAMARTISPVIFKSQLVRLFSTMDLSCFHSILQMKAVFTDSLFTGEDEHFLIQRLVGMTQHPLLSTPVKLFYLDCLLHFPENRPLTSNSEENLPVLLTVQMTSSLFPNVFNDHSTMLCRQNVLSMVYLENEGSYSEKGIAFLFEHVMSLYSMVHKNGNREITATFFRAVHLFVQYFNFCEKHMENLTEKLLKLYMSNSSLAPNFINLINQTQILLEFHVWPVTLSKALQKEIVNLPTDKWTMKNLGWHLKILSRVAQENSISQSSTALFLRRVVFCSDLCSKGDWRTGNALLSVCKHVLQHQKLSAIFVHLADLLQYLMHRFEDIDVQDRARLYYVLLTNVSSDKLGKILTMSPARGQTKSRSLSSIMTENENFSTMLTIRNAEKTLLCLQPVLEGIKAFTCISDSPSLYCIVLQFENTDCRFESISDINVPCLFVDRKPPVVTINLVPKEPYPTIFSVSATYSTQDGITYQTKLDPLYITFREMFIPLPLPALWPLESRFDLFGKLWSAFKPDEQNQFEESIFCYEMSNNSLHDIVLDNFSKFAVSCNGGEYKIAVFLPPQFHILMHIKSQDDTACFSVRTDNWNLLPYLNSHLLDITLQ", "function": "As part of AP-5, a probable fifth adaptor protein complex, it may be involved in endosomal transport.", "AFDB_id": "AF-F6S215-F1-model_v4" }, { "swissprot_id": "Q96L11", "sequence": "MPPLAPQLCRAVFLVPILLLLQVKPLNGSPGPKDGSQTEKTPSADQNQEQFEEHFVASSVGEMWQVVDMAQQEEDQSSKTAAVHKHSFHLSFCFSLASVMVFSGGPLRRTFPNIQLCFMLTH", "function": "Sperm protein required for fusion of sperm with the egg membrane during fertilization.", "AFDB_id": "AF-Q96L11-F1-model_v4" }, { "swissprot_id": "H2VFV1", "sequence": "MTVSTDNTSPVISRASSPTFGDHGKDFDNNKIIPISIEAPTSSAAAVGAKTAIEPEGRSPLLQRICYLVKIIAAIALFVVGIAALVCLYLGSVISTPSLILMLAIMLVSFVIVITAIRDGTPSQVVRHMKQQIQQFGEENTRLHTAVENLKAVNVELSEQINQLKQLHTRLSDFGDRLEANTGDFTALIADFQLSLEEFKSVGTKVETMLSPFEKLAQSLKETFSQEAVQAMMSSVTELRTNLNALKELITENKTVIEQLKADAQLREEQVRFLEKRKQELEEACSTLSHSIATLQESTTLLKDSTTNLHAVESRLIGVMVQDGAESSTVEEASQDDSAQPQDENQSDAGEHKDS", "function": "Chlamydia replicate within a host intracellular vacuole, termed an inclusion, which is formed by fusion of many smaller inclusion bodies. IncA is probably involved in the homotypic fusion of inclusions.", "AFDB_id": "AF-H2VFV1-F1-model_v4" }, { "swissprot_id": "Q8NFU3", "sequence": "MAGAPTVSLPELRSLLASGRARLFDVRSREEAAAGTIPGALNIPVSELESALQMEPAAFQALYSAEKPKLEDEHLVFFCQMGKRGLQATQLARSLGYTGARNYAGAYREWLEKES", "function": "Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism. Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate. The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor.", "AFDB_id": "AF-Q8NFU3-F1-model_v4" }, { "swissprot_id": "Q9I4V0", "sequence": "MGVFRTRFTETFGVEHPIMQGGMQWVGRAEMAAAVANAGGLATLSALTQPSPEALAAEIARCRELTDRPFGVNLTLLPTQKPVPYAEYRAAIIEAGIRVVETAGNDPGEHIAEFRRHGVKVIHKCTAVRHALKAERLGVDAVSIDGFECAGHPGEDDIPGLVLLPAAANRLRVPIIASGGFADGRGLVAALALGADAINMGTRFLATRECPIHPAVKAAIRAADERSTDLIMRSLRNTARVARNAISQEVLAIEARGGAGYADIAALVSGQRGRQVYQQGDTDLGIWSAGMVQGLIDDEPACAELLRDIVEQARQLVRQRLEGMLAGV", "function": "Catalyzes the NADH-dependent reduction of a broad spectrum of quinone substrates, generating the corresponding hydroquinones. Highly prefers NADH to NADPH as a reducing substrate. Also displays a small NADH oxidase activity. Does not exhibit nitronate monooxygenase activity; is inactive against propionate 3-nitronate, 3-nitropropionate, nitroethane, 1-nitropropane, 2-nitropropane, and the anionic forms ethylnitronate, propyl-1-nitronate, and propyl-2-nitronate. Has no azoreductase activity since it is not able to reduce the azo dye methyl red with NADH. May be required to maintain an appropriate [NAD(+)]/[NADH] ratio for the catabolism of fatty acids in P.aeruginosa PAO1.", "AFDB_id": "AF-Q9I4V0-F1-model_v4" }, { "swissprot_id": "Q9LFR7", "sequence": "MATISFSHNHQSSDNRRGGSHHHRHGPVVEEIEGLIKVFNDGCVERPPIVPIVSPTIHPSSKATAFDIKLSNDTWTRVYIPDAAAASPSVTLPLLVYFHGGGFCVGSAAWSCYHDFLTSLAVKARCVIVSVNYRLAPEHRLPAAYDDGVNVVSWLVKQQISTGGGYPSWLSKCNLSNVFLAGDSAGANIAYQVAVRIMASGKYANTLHLKGIILIHPFFGGESRTSSEKQQHHTKSSALTLSASDAYWRLALPRGASRDHPWCNPLMSSAGAKLPTTMVFMAEFDILKERNLEMCKVMRSHGKRVEGIVHGGVGHAFHILDNSSVSRDRIHDMMCRLHNFIHPS", "function": "Carboxylesterase acting on esters with varying acyl chain length.", "AFDB_id": "AF-Q9LFR7-F1-model_v4" }, { "swissprot_id": "P39718", "sequence": "MPPPSRSRINKTRTLGIVGTAIAVLVTSYYIYQKVTSAKEDNGARPPEGDSVKENKKARKSKCIIMSKSIQGLPIKWEEYAADEVVLLVPTSHTDGSMKQAIGDAFRKTKNEHKIIYCDSMDGLWSCVRRLGKFQCILNSRDFTSSGGSDAAVVPEDIGRFVKFVVDSDVEDVLIDTLCN", "function": "Involved in peroxisome biogenesis.", "AFDB_id": "AF-P39718-F1-model_v4" }, { "swissprot_id": "Q8DH26", "sequence": "MPRPAVFLDRDGVLNQEVGYIHRLEDLQLIPGVAQAVRRLNDAGWFCCLASNQSGPARDYYSIDHVHALHHRLQELLAASAGAVLDAVYFCPDLSRPEGGVVADYAGWTTWRKPNTGMLVAAAWDHDLDLSRSVMVGDKATDIDLARNAGCYGILVQTGFGDRVLEGSYQHASQPDYIAEDLAAAVEWICTHLAPR", "function": "Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.", "AFDB_id": "AF-Q8DH26-F1-model_v4" }, { "swissprot_id": "P30414", "sequence": "MGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDGVHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSESSRYS", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells.", "AFDB_id": "AF-P30414-F1-model_v4" }, { "swissprot_id": "Q8EWZ1", "sequence": "MEEKNHIDHYANALYSIWLELDKKNKIIFTSSAKDIYFSLKNNYEMVHIIDSNIISKEEKTKILNKIFFDLSKSISNIYLKNFLFVLNDNNFFKRILEIFISFFQKLDEHQNFLFIRIYSPFVVEKKLLEKIEHLFSIKTGKRVRYENIIDKSLIGGMKIMFGNDVYDYSIKGKIDQIKWNIENNKEV", "function": "This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.", "AFDB_id": "AF-Q8EWZ1-F1-model_v4" }, { "swissprot_id": "A0A067XMT3", "sequence": "MPSPTNPAKVETPFTTAALGNGVDFWKAYVENRPHPSDSFFELISEYHHSHGDSAAQSAIAHDVGTGPGNIAEKLLRHFDHVVGSDVNEQALAAAPALLPADSIKRMTFVKSSAEDLASANIPESVGKGQTDLILVSECIPLLDISKAFAAFRALLRPGGTLAIYFYSRPIFTGDNEAELNQLYDRIATRVCQFLLPFKGTPGFPIHYRAAEAMSSGLDSIPFDPEAWQDVVRYKWNADVPLTFNSKEGYDFEVEPVDRRDHSTEITKEITDRDFWAEEWDIGRVASFLDSVFPNYRNKAGDKFEEVQSLFTELETALGGPKATRKVSFPVVLLLATRK", "function": "Methyltransferase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes. The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA. As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain. The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone. Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC. Spontaneous decarboxylation of endocrocin occurs to generate emodin. An O-methyltransferase (ptaH or ptaI) could methylate emodin to form physcion. PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin. PtaF, a putative NADH-dependent oxidoreductase, might also participate in the oxidative cleavage step. Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin. Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin. PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulouchrin and chloroisosulochrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination.", "AFDB_id": "AF-A0A067XMT3-F1-model_v4" }, { "swissprot_id": "Q9LT69", "sequence": "MATSLNLSSIFSSSSRLVTTPSSVFPIRQRRRIILVTSSSSGGGGKPTILVTEKLGQAGIDLLKKYANVDCSYDLSLEELCTKISLCDALIVRSGTKVGRDVFESSRGRLKVVGRAGVGIDNVDLAAATEYGCLVVNAPTANTVAAAEHGIALLTAMARNIAQADASIKAGKWTRNKYVGVSLVGKTLAVLGFGKVGSEVARRARGLGMHVITHDPYAPADRARAIGVELVSFEVAISTADFISLHLPLTAATSKMMNDVTFAMMKKGVRIVNVARGGVIDEEALLRALDSGIVAQAALDVFTVEPPVKDNKLVLHESVTATPHLGASTMEAQEGVSIEVAEAVIGALRGELAATAVNAPMVPLEVLRELKPYVVLAEKLGRLAVQLVTGGSGVNAVKVTYASSRAPDDLDTRLLRAMVIKGIIEPISSVFINLVNSDYIAKQRGVKISEERMVLDGSPENPIEYITVRIANVESRFASALSESGEIKVEGRVKQGVPSLTKVGLFGVDVSLEGSVILCRQVDQPGMIGKVASILGDENVNVSFMSVGRIAPGKQAVMAIGVDEQPSKETLKKIGDIPAIEEFVFLKL", "function": "Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB).", "AFDB_id": "AF-Q9LT69-F1-model_v4" }, { "swissprot_id": "Q9M9H7", "sequence": "MSKLRFFQSLLISTVICFFLPSINARGGHSDHIHPGDGNYSFHGIVRHLFAQEEPTPSLELTRGYMTNDDLEKAMKDFTKRCSKISRLYSIGKSVNGFPLWVIEISDRPGEIEAEPAFKYIGNVHGDEPVGRELLLRLANWICDNYKKDPLAQMIVENVHLHIMPSLNPDGFSIRKRNNANNVDLNRDFPDQFFPFNDDLNLRQPETKAIMTWLRDIRFTASATLHGGALVANFPWDGTEDKRKYYYACPDDETFRFLARIYSKSHRNMSLSKEFEEGITNGASWYPIYGGMQDWNYIYGGCFELTLEISDNKWPKASELSTIWDYNRKSMLNLVASLVKTGVHGRIFSLDKGKPLPGLVVVKGINYTVKAHQTYADYHRLLVPGQKYEVTASSPGYKSKTTTVWLGENAVTADFILIPETSSRGNQLRSSCDCSCKSCGQPLLTQFFTETNNGITLTLFVVVVFLCFLLQRRVRFNLWKQRQSSRRSITV", "function": "Possesses in vitro carboxypeptidase activity against the C-terminal arginine and lysine residues. Involved in the maturation of CLE19. Removes the C-terminal arginine residue of CLE19 proprotein. The cleavage of the C-terminal arginine residue is necessary for CLE19 activity in vivo. Is not involved in generating active CLV3. Is not involved in CLE19 or CLV3 perception.", "AFDB_id": "AF-Q9M9H7-F1-model_v4" }, { "swissprot_id": "Q67KH4", "sequence": "MSTPVTRTQVPDGVRDRLPSEAAAMRRLSARLDNVFRAWGYREVSTPVIEYLEAVAAGAANWGRREDLYQFFDRKGRTLALRPDMTTPIARLMATRLADEPLPLRLSYFAPVFRHRELRAGATSEIWQAGVELVGAPGEAADAEVISLACAAVRAADLTGFRIGLGHVGVVEGLFESAGVDPQAAAVLKEAMVARDLVAFEQGVARAGLSGERAERLLALVHFHGSYAEAVARFGGVGGRVAEALQHLGRVLEVLEALGVAEQVNLDLGLVRSLGYYTGVVFEGYLPGIGAPVLGGGRYDNLVAEFGRPLAATGFALEVDRLLMAQEQQGALAAEPGLDAVIACPPGQEAAAMAWAARLRAQGLAVEVDFLDRTGEELAAYARARAAARVLRPGVPSIH", "function": "Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.", "AFDB_id": "AF-Q67KH4-F1-model_v4" }, { "swissprot_id": "Q6AXX6", "sequence": "MSFLQDSSFFSMGMWSIGVGAFGAAALALLLANTDMFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVVKEKVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMLMGLVRLGVWYNSFRAWKGGFSGNFEGEGFILGGVFVIGSGKQGVLLEHREKEFGDRVNLLSVLEAVKKIKPQTPASRQS", "function": "Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.", "AFDB_id": "AF-Q6AXX6-F1-model_v4" }, { "swissprot_id": "Q9KKZ4", "sequence": "MMTTEDFKKSTANLKKVVPLMMKHHVAATPVNYALWYTYVDQAIPQLNAEMDSVLKNFGLCPPASGEHLYQQYIATKAETNINQLRANVEVLLGEISSSMSDTLSDTSSFANVIDKSFKDLERVEQDNLSIEEVMTVIRRLVSDSKDIRHSTNFLNNQLNAATLEISRLKEQLAKVQKDALFDSLSGLYNRRAFDGDMFTLIHAGQQVSLIMLDIDHFKALNDNYGHLFGDQIIRAIAKRLQSLCRDGVTAYRYGGEEFALIAPHKSLRIARQFAESVRRSIEKLTVKDRRSGQSVGSITASFGVVEKIEGDSLESLIGRADGLLYEAKNLGRNRVMPL", "function": "Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation, and reduced motility and virulence.", "AFDB_id": "AF-Q9KKZ4-F1-model_v4" }, { "swissprot_id": "Q6DK85", "sequence": "MSNQELVTLNVGGMKFSTLSATLRRFPDSRLARMLDNADREIRIINGHYFIDRDGSLFSYILDYVRTSQLSLPSGFSEFERLQREAEFYQLLSLADLLSQDTLYRPRVEILEVRFLLQETHAFFRLFCSSSTTIEMMADRILMFAEQPMGSQGWSFPFSAQKPLAPVPLQRPSHHDVVFQCGTDYTNGEHVGARYVSIKPDQRKLINGTNVLGLLLDILLKEGFCLISTRSVSAEEKVECYTFERKKRPEVLTIHENSRQENYETETVQVKQAKPNKKR", "function": "Inhibits potassium fluxes in cells, possibly by retaining potassium channels in the cytoplasm.", "AFDB_id": "AF-Q6DK85-F1-model_v4" }, { "swissprot_id": "O34928", "sequence": "MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDAGKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGHFVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNLYLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAIYLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL", "function": "Catalyzes the deacetylation of N-acetylmuramic acid (MurNAc) residues in glycan strands of peptidoglycan, leading to the formation of muramic delta-lactam residues in spore cortex, after transpeptidation of deacetylated muramic acid residues. PdaA probably carries out both deacetylation and lactam ring formation and requires the product of CwlD activity on peptidoglycan as a substrate. Is required for germination. Cannot use chitin oligomer (hexa-N-acetylchitohexaose) as a substrate.", "AFDB_id": "AF-O34928-F1-model_v4" }, { "swissprot_id": "P15370", "sequence": "MNQLCKVCGEPAAGFHFGAFTCEGCKSFFGRTYNNIAAIAGCKHNGDCVINKKNRTACKACRLRKCLLVGMSKSGSRYGRRSNWFKIHCLLQEQQTTSGLGGGSSVGSGSGGGVSSASLEQLARLQQASNQARQTYQDKTNPCIKSATATTSPRIEGAAVGTGIGGGASPSFLQAAKLHHQRQLKLDSRLSNTPSDSGASSAGDPNEDGVTSVLGGQIATPSSTNATSLPKLDLRHPNFPATSEPDADMQRQRHQELLEIFRSHSEPLYSSFAPFSHLPPVLLAAGVPQLPIFKDQFKAELLFPTTSSPELEEPIDLSFRSRADPASPMAHNSNSPSLSEPAAASHCLGESTNFVRKSTPLDLTLVRSQTLTG", "function": "May play a critical role in development of the progeny of eagle-positive neuroblasts.", "AFDB_id": "AF-P15370-F1-model_v4" }, { "swissprot_id": "P87306", "sequence": "MAEEANKDADISSLSLSLDPEIIGGQNNFLENNLQQIFQKIIQERGPFRDLKEEDLQKELQKESIKDESSAKSSETENVLEFATLDSKRNVNDTEVESMDSQAYKKELIEQIMIAQTECSLALDMTSLLLSKFKENSIETISPFLKSTVPPSSLQFSRSQPPESKESDATLAKCWKEKSLTSSCKFLFEAKERLTSVVETEHEYYTELVKVKEASWPLFNSQGSNHLSVQYSCLGGISLGLGLIRMKPESKSFEVQSSLLYSQAALKISILNKDRDEIGSSTWSWPSQNCNSVLLKDIYKLQEILFEMDIWNSLLQEAQSCGNQGVNFTGDEILVPISDDHVVRITLETSSKNTESGFTEDKKSNEDTSTNFVTIKQEKELLKCLCDTLNAIAHILFLKHCRKSDRRSQQPELYMAIDANAPLILRPLIFYYNLNQESLEFQRWLKQRDISFKFMPNYPWEKAKDFLELENSLSINRLSISWRIMVSNFEPAIFIQHTPTLHGTDKSVWRCKDQYSSNQFSSLKNVCQYIEHHINSLSRRSKKTE", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.", "AFDB_id": "AF-P87306-F1-model_v4" }, { "swissprot_id": "Q10MN3", "sequence": "MVTAAGSPSSSSARKPASRPRLPCRDILVHIEAYLSRRDGVDNLLKVSLYAARLALALAAGQPPLPHAATARLRSFESSVGLSRKAFRLGKFVQSINALRAAAYHPHPHVHPLLVLLAYGGQGVYNFLEQFAWLAKAGLLPARLLPRRLHRIGVWAQLLAHVGSIAIKLEEVAELECGVEARLEEGCGEESEVVRTLSRKLLLKLMSLVQDMVDSAMTVGDVTGRKGLLGSSTLMASAGLLSALISVHKNWNSC", "function": "Involved in peroxisomal proliferation.", "AFDB_id": "AF-Q10MN3-F1-model_v4" }, { "swissprot_id": "O30807", "sequence": "MNTGDKAKSQAVPASGDIDQQALFFHRYPRPGKLEIQPTKPLGNQRDLALAYSPGVAAPCLAIKDNPETAADFTARANLVAVVSNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIEIDAPTVDRMVDVISALEPTFGGINLEDIKAPECFEVERRLREKMEIPVFHDDQHGTAIIVAAAVLNGLELAGKDIAEAKIVASGAGAAALACLNLLVTLGARRENIWVHDIEGLVYKGREALMDEWKAVYAQESDNRVLADSIGGADVFLGLSAAGVLKPELLARMAEKPLIMALANPTPEIMPEVARAARPDAMICTGRSDFPNQVNNVLCFPHIFRGALDCGARTINEEMKMAAVRAIAGLAREEPSDVAARAYSGETPVFGPDYLIPSPFDQRLILRIAPAVAKAAAESGVATRPIQDFDAYLDKLNRFVFRSGFIMKPVFAAAKNAAKNRVIFAEGEDERVLRAAQVLLEEGTAKPILIGRPQIIETRLRRYGLRIRPDVDFEVVNPEGDPRYRDYVDDYFALVGRLGVIPEAARTIVRTNTTVIGALAVKRGEADALICGVEGRYSRHLRDVSQIIGKRSGVLDFSALSLLISQRGATFFTDTYVSFSPSAEEIAQTTVMAANEIRRFGITPRAALVSHSNFGSRDSESAFKMRTALQLVRELAPDLEVDGEMHGDSAISEVLRQRVMPDSTLNGEANLLVFPNLDAANITLGVVKTMTDSLHVGPILLGSALPAHILSPSVTSRGVVNMAALAVVESSHPV", "function": "Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria.", "AFDB_id": "AF-O30807-F1-model_v4" }, { "swissprot_id": "Q96EG3", "sequence": "MEAPAQKAGQGGLPKADAQGASGAREKRPEEPRPLEEDRAGSRPTQKGDLRGAAGGRTTPPGGGSRGCSLGVSPGPGTRHSAGTRPLVREPCGPTSSQNPELVIPEGLQAREGPCRSPARGGDCSRNSCLAWHRGAPAGETPPVCDPCPERIQNHPRTQLCEVHTDCWPCQPGTGAPTCPRTPKPTSRGRNPLVEQPRACACGEAFAWRALRIPQERLQATEEPRPCARCGKRFRPNQQQQAGKSPPVCPECGQTSRPRPIVPDPPAQRLYACDECGKAFTRTSSLLQHQRIHTGERPYECAECGKAFVRCSGLYRHQKTHSAERHRRGPVLARRAFRLGCPPCGDYSERSPRRGSGAGEKPYECADCAKAFGLFSHLVEHRRVHTGEKPYACPECGKAFNQRSNLSRHQRTHSSAKPYACPLCEKAFKGRSGLVQHQRAHTGERPYGCSECGKTFRGCSELRQHERLHSGEKPYICRDCGKAFVRNCSLVRHLRTHTGERPYACGDCGRAFSQRSNLNEHRKRHGGRAAP", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q96EG3-F1-model_v4" }, { "swissprot_id": "Q9H1C4", "sequence": "MEAEPPLYPMAGAAGPQGDEDLLGVPDGPEAPLDELVGAYPNYNEEEEERRYYRRKRLGVLKNVLAASAGGMLTYGVYLGLLQMQLILHYDETYREVKYGNMGLPDIDSKMLMGINVTPIAALLYTPVLIRFFGTKWMMFLAVGIYALFVSTNYWERYYTLVPSAVALGMAIVPLWASMGNYITRMAQKYHEYSHYKEQDGQGMKQRPPRGSHAPYLLVFQAIFYSFFHLSFACAQLPMIYFLNHYLYDLNHTLYNVQSCGTNSHGILSGFNKTVLRTLPRSGNLIVVESVLMAVAFLAMLLVLGLCGAAYRPTEEIDLRSVGWGNIFQLPFKHVRDYRLRHLVPFFIYSGFEVLFACTGIALGYGVCSVGLERLAYLLVAYSLGASAASLLGLLGLWLPRPVPLVAGAGVHLLLTFILFFWAPVPRVLQHSWILYVAAALWGVGSALNKTGLSTLLGILYEDKERQDFIFTIYHWWQAVAIFTVYLGSSLHMKAKLAVLLVTLVAAAVSYLRMEQKLRRGVAPRQPRIPRPQHKVRGYRYLEEDNSDESDAEGEHGDGAEEEAPPAGPRPGPEPAGLGRRPCPYEQAQGGDGPEEQ", "function": "Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.", "AFDB_id": "AF-Q9H1C4-F1-model_v4" }, { "swissprot_id": "O13601", "sequence": "MARTAFHDEFVDYYTILGAESTSSYVEIRQQYLKLVLRYHPDRNPGREAEVLPQFQLIQKAHEVLKDPKLRELFDQRRLLEAGRPDGVLRFRPKKSGPKNDISTKVASKVSVTMATKFAEKKKKQDRENVDSKDNNITNFSLHRSFSASGKMEKNNSFKEVSTSKSYISSGYLHPKTSPIFKKNGYATENVVDPISSSPRFKGPNYNKFNAKLYLESLREKRRTYTPLSEISNGLNSNGVENSSITKSSPRSSSSSNNERFKDTSEESIIFTSPNTPEHPSVYQTDITPEIKLEHSDNNSPSKPEIPFRHPTSKPLPPKPLSRSKSSSLSRNQTRSQLNDLSAENDSTSNSTEYDDQLQSILRSLAIEGDDDEVAKVLPKPPSVPTIQAPIPPEAPRNLTNASVDSYLNSFEMYQRRWSSYSIIYTQYAFQWQIFKNKCFQLDLMNTPGQSRLIDNWKEGSQAIQLFYAYEQMHLRALEELQSLKESLFASFGI", "function": "Has a role in the proper organization of the interphase microtubule cytoskeleton. Required for equatorial microtubule organizing center (eMTOC) disassembly into satellites, contributing to the dynamic redistribution of MTOC components for organization of interphase microtubules.", "AFDB_id": "AF-O13601-F1-model_v4" }, { "swissprot_id": "G4N2A1", "sequence": "MSSAAASATAGSVTGKTPRILACVLCQHRKIKCDRSFPCANCQRANVQCTPSTPAPARKRRRPNQDLQERLARCEELLKEYAPDGKPDIARLTTKRSSLSQSPPKGEEPLPEWNRHGKLIHEDGSVRFVDSYMLSTIYDELRAMRDIIDHDESTPEDESSDYMTPDTNADLLFGGDTPQPAGNSMELQPSPGHIFRLWQVFLDRVNPLIKLVHVPSLQPYFVEATAGAPLPKNIEALLFSIYTLAAVSLSDAECTSILGYGREAALHRFSSGVRASLIRIGFLKTHDLTTLQALVHYLISLQGRYNRHAAWVLNGVVIRIAQKMGIHRDGTMLGLPPFETEMRRRLWFQILSMEFKTALMSGLGHSLLPRVWDTQEPKNVNDADLHPSATEPVKDREGPTEMIFVLITNKVARFIVESPGIEPIFLYHDEKVKKIPGAPSEEKIKEFRGLIDGLSKSLLELTDKYCDPAAGPLHQYTIEFQDIIMQRIRESLEPGDATIETHIDHMFKMAVESFESTVVSYRNSCKVAYLWFLRLQFHNDLFTFLAGQLSQRPSGPLVDRAWETVENILPYHPELLKVNASKENLLLASLLVKGWNMREEYCSTQMGITLNTPPYIEHLRSVVPQDYVKSENSSPSALSRIPKANRMVTREAASDQLSVSGPMDPTFDEFIGNYLDGADWDVFSRINLENPAFPGVPATGITPQVNATASDILPSTRIDHTDPNQTSHQFAMYGIDPQSAWQ", "function": "Transcriptional regulator; part of the gene cluster that mediates the biosynthesis of pyriculol and pyriculariol, two heptaketides that induce lesion formation upon application on rice leaves but are dispensable for pathogenicity. With TRF2, negatively regulates the expression of the gene cluster and the subsequent pyriculol and pyriculariol production.", "AFDB_id": "AF-G4N2A1-F1-model_v4" }, { "swissprot_id": "Q54VE0", "sequence": "MNSSALNLIQFLESSKIQVPGGLKSVKGILDFDFYDLVKNIGESTSREEEVHIIQNEIIKLKSCFSKEQSKDKKRECLIRMIYCHMLGYDVPFGHIQALNMTQDSEILNKRTGYLTLSLCLPERHELLIMAVNSILKGLNSSNYLEVCSALTAMCKLIDNDTIPAFLQKVLQLLNHQKPIVRKKSVTVLHRFYRLVGDSFLDDDQIIDKLRQSLCDRDPSVMSASICIFLDISEKHSTLKDNNNQINNNNNNNNSNQIKKKNNEEINRSKNLISMLKELVPSFVGILKQVAEGRLPNSYIYHGIHHPWLQINLLKLLSNLGYQDKDSSNHMYTVLLFTMQQSQKFKNNVGFAILYETIKTLTLIHPNLQLIEQCSKNIAIFLKGKHHNLRYFGIKALASIVKVSPKLVLPYQVEVIESLESPDETLKRKSFDLLYKMTNQTNVVPVCSKLIEQLVLSKDQNFKSELISQITNIAEKYSPNDIWYIDTISTVLSILPNENNKDNNNNNNNNNNNNNNYQFAYNLIRLVSEEDDIKVKQHISEIYLNNIMISNEQQQQQQQENQNNLQQFSDIYIKIMSWVISEYSNLIVSNNGVIESDIISYLCDLLEKDYQGETKSWIIIGIGKLVAQLGKSLPMLELMTKKFKSSKSLICQQRSSELNEILKNPKSMSLILPLDAYCEDIDFNKIFNKFNDYSNKVGGKQYIPYEKRKNTPLVDISDGSSSHSNEKGLNFQYPPPPDPFNPHHNQQQLYPVHQHQPPSNHQQQQQQQQQQQQQQLQLFPQQPQQPQQLLLLGEDDTINLNNNSLVPVNNDQQLQPHQHQQQQQNQQQQQQNQQQQQQQNPQYPNNQLVTVPDQNAPKPIGLPKPSKVLWTKKGFVGNKQTPPQNATPQQQQQQQQQQTQNTLSQQQIQKHQQTHNNIDPEKEKLAKQLFGGFSENNNRNENSNNTDNNQNNVGITSKLQNKKSNNENNINNNKKESYLEELIDLSPNLISNINITNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNLLLVDVEGDEQKEVKNSSCSSGNSELINLNLDENTTKNINGNLLGDDLEELNKN", "function": "Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways.", "AFDB_id": "AF-Q54VE0-F1-model_v4" }, { "swissprot_id": "A0A0A7HF73", "sequence": "MKKLVFTFKRIDHPAQDLAVKFHGFLMEQLDSDYVDYLHQQQTNPYATKVIQGKENTQWVVHLLTDDHEDKVFMTLLQIKEVSLNDLPKLSVEKVEIQELGADKLLEIFNSEENQTYFSIIFETPTGFKSQGSYVIFPSMRLIFQSLMQKYGRLVENQPEIEEDTLDYLSEHSTITNYRLETSYFRVHRQRIPAFRGKLTFKVQGAKTLKAYVKMLLTFGEYSGLGMKTSLGMGGIKLEERKD", "function": "This protein processes pre-crRNA into individual crRNA units.", "AFDB_id": "AF-A0A0A7HF73-F1-model_v4" }, { "swissprot_id": "Q12FG5", "sequence": "MTSSSPARPPVAAASTPSDAKVALGWLHTAKFLTTAPELKHLPRLDVPEIAFVGRSNAGKSTCINTLTQQHRLAFASKTPGRTQSINLFSLGKQGVTDAVLADLPGYGYAAVPKEAKYRWQQVMGNYLQTRDNLKAVVLLCDPRLGLTELDEILLDVLRPRVEEGLKFLVLLTKSDKLNKTEAAKALSIVRLQAGGGDVKLFSSLKRKGVEEVAQHLWDWAHPPEKPAKKPKAEPAAEAATGDEG", "function": "Necessary for normal cell division and for the maintenance of normal septation.", "AFDB_id": "AF-Q12FG5-F1-model_v4" }, { "swissprot_id": "P87133", "sequence": "MIRYSLNGIRLFGSLNLFNATRILPISLGRASYAHARLFTSKVEKSGTAEESALPSVDEEEDKLNSLLGNIKVRTAQEDGVSVEEVLMHHPELLRNAPHALQQSVKEILASKEVGDAFKKN", "function": "Has a role in meiosis.", "AFDB_id": "AF-P87133-F1-model_v4" }, { "swissprot_id": "A8XPH5", "sequence": "MSFITAFGDRVFVASGDLIRTFRIGDDEGMTPLISWSELNPERIQKPSFEAEKDLKAVDKRVILCLAHSNMIAAHGRRLVAVGTNEKQIHVFEYFIDNNYKIVKAEHIVTSVVPKAPTAIVFDREDAYVVVGDRSGDVHRFSVLNGSAIEMAGAISMILDVAFSPDGKRLLMADRDEKVRAMRYPSTYVIDAYCLGHTEYVKTLAIQDNDTVWSSGGDKNLHMWSITNCSKPRRTIDLSEWDAPVRKISINVAHKKIAVLFEKKDKMIVVDLETDPAATQSVTILNESECLDVTSTGHYFIVLGRSTITVINLLTMLQATFPIDDELNAVLSATKDAVDNLFKNVTHNNQLEYEKRKAEKFEQIEQKRRRLNNQEPSTS", "function": "Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.", "AFDB_id": "AF-A8XPH5-F1-model_v4" }, { "swissprot_id": "Q06597", "sequence": "MVSFITSRQLKGLIENQRKDFQVVDLRREDFARDHITNAWHVPVTAQITEKQLNQLIKGLSDTFSSSQFVKVIFHCTGSKNRGPKVAAKFETYLQEEDITSKFESCILVGGFYAWETHCRESNLKLIVSG", "function": "Involved in resistance to arsenic compounds.", "AFDB_id": "AF-Q06597-F1-model_v4" }, { "swissprot_id": "Q9HCE9", "sequence": "MAEAASGAGGTSLEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYLVSHKAWMKTVPTENCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTATYESLLRGADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQAVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQLLVSLPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIWLNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLITRQFLQNVREVLQPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRLEPQADEGGGGGSGGGGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEEDEEEEEDEEEGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTLAEEDDEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPEAAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQHRYQQQQRRRREEEERQRHAEHHARREHDSGGREEARAEGSGLDPATSSEKASAKAKGSTAGGHGPERPKRPGSLLAPNNVMKLKQIIPLQGKFLSSGATSSLAAAGAGATTRPPPAQSPTGSDTRLPAFLSFKFLKSPETRRDSERSHSPPKAFHAGKLFPFGGTRAEPGSNGAGGQARPDGTPSSGSSRVQRSGPVDEALAEELEAPRPEEEGSGTALAPVGAPALRTRRSRSPAPPPPMPLPRPPTPPAGCWQWDGPWGCGGEGAAPRQALAAAECPPCAMAGPPPAPQPLPGDASFYSLPPPPLPPTSDPLETPAPSPSPSPSPQAVCWPSGWH", "function": "Does not exhibit calcium-activated chloride channel (CaCC) activity.", "AFDB_id": "AF-Q9HCE9-F1-model_v4" }, { "swissprot_id": "P30204", "sequence": "MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS", "function": "Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).", "AFDB_id": "AF-P30204-F1-model_v4" }, { "swissprot_id": "Q64548", "sequence": "MAAPPDLQDEPLSPANPGSQLFGGRGEGEEATPKGARPAQQDGEPAWGSGAGAGVVSSRGLCSGPARSPPVAMETASTGVAAVPDALDHSSSPTLKDGEGACYTSLISDICYPPREDSAYFTGILQKENGHITTSESPEELGTPGPSLPEVPGTEPHGLLSSDSGIEMTPAESTEVNKILADPLDQMKAEACKYIDITRPQEAKGQEEQSPGLEDKDLDFKDKDSEVSTKPEGVHAPNQPSPVEGKLIKDNLFEESTFAPYIDELSDEQHRMSLVTAPVKITLTEIGPPVMTATHETIPEKQDLCLKPSPDTVPTVTVSEPEDDSPGSVTPPSSGTEPSAAESQGKGSVSEDELIAAIKEAKGLSYETTESPRPVGQAADRPKVKARSGLPTIPSSLDQEASSAESGDSEIELVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPGVLDAIREETSSRATEERAPSHQGPVEPDPILSFTPVTLQSRPEPSSGDGAPVPEPPKSQQQKPEEEAVSSSQSPAATEIPGPLGSDLVPPLPFFNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQYLGLVRTHINTVVAKIQAKIPGAKRHAE", "function": "Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.", "AFDB_id": "AF-Q64548-F1-model_v4" }, { "swissprot_id": "Q8GJN6", "sequence": "MGREGWSRVLSATGENRERSLQKFMTETLTQLGQMVGLPASPEVAVLETFDNPHPDRQYLVRFVAPEFTSLCPLTGQPDFAHLVLDYVPDQRLVESKSLKLFLGSFRNHGAFHENCTLTIAKRLEEAMNPTWLRLGGYWYPRGGLPIDVFYQSGEPPAGVWVPEQGVAPYRGRG", "function": "Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).", "AFDB_id": "AF-Q8GJN6-F1-model_v4" }, { "swissprot_id": "Q75D33", "sequence": "MIRYALLRSGRRTLQTRPSPQTLEELARLKSLEDVDSSVIRKLINQRTEEVNAQNEAQMLKKLSAEGRDLQNVPGSRYARPLWLLLIGCASVYLVRDWLRMKAEYDARETTLETRVEGLEAELKYLLEPKPGVLEVEVVQTEVASSAPWYKRWLWSGSR", "function": "Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain.", "AFDB_id": "AF-Q75D33-F1-model_v4" }, { "swissprot_id": "Q8WUM0", "sequence": "MFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSSRGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEVDDQLTINIDEGGWACLVCKEKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATREGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKIHQHILPQGQGMLSGIGRKVSSLFGILSPSSDLTLSSVLWDRERSSFYSLTSSNISKWELDDSSEKHAYSWDINRALKENITDAIWGSESNYEAIKEGVNIRYLDLKQNCDGLVILAAAWHSADNPCLIYYSLITIEDNGCQMSDAVTVEVTQYNPPFQSEDLILCQLTVPNFSNQTAYLYNESAVYVCSTGTGKFSLPQEKIVFNAQGDSVLGAGACGGVPIIFSRNSGLVSITSRENVSILAEDLEGSLASSVAGPNSESMIFETTTKNETIAQEDKIKLLKAAFLQYCRKDLGHAQMVVDELFSSHSDLDSDSELDRAVTQISVDLMDDYPASDPRWAESVPEEAPGFSNTSLIILHQLEDKMKAHSFLMDFIHQVGLFGRLGSFPVRGTPMATRLLLCEHAEKLSAAIVLKNHHSRLSDLVNTAILIALNKREYEIPSNLTPADVFFREVSQVDTICECLLEHEEQVLRDAPMDSIEWAEVVINVNNILKDMLQAASHYRQNRNSLYRREESLEKEPEYVPWTATSGPGGIRTVIIRQHEIVLKVAYPQADSNLRNIVTEQLVALIDCFLDGYVSQLKSVDKSSNRERYDNLEMEYLQKRSDLLSPLLSLGQYLWAASLAEKYCDFDILVQMCEQTDNQSRLQRYMTQFADQNFSDFLFRWYLEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHATLLGLANMETRYFAKKKTLLGLSKLAALASDFSEDMLQEKIEEMAEQERFLLHQETLPEQLLAEKQLNLSAMPVLTAPQLIGLYICEENRRANEYDFKKALDLLEYIDEEEDININDLKLEILCKALQRDNWSSSDGKDDPIEVSKDSIFVKILQKLLKDGIQLSEYLPEVKDLLQADQLGSLKSNPYFEFVLKANYEYYVQGQI", "function": "Involved in poly(A)+ RNA transport. Involved in nephrogenesis.", "AFDB_id": "AF-Q8WUM0-F1-model_v4" }, { "swissprot_id": "A1CIM4", "sequence": "MPAGYASTARALSLPMSPSGTPSPADDDIQSPPWGHLIPNRQNTPSPSIREATSFRDQITSQATRLLYRMKKTWRRLNFWQRVGAIGAVILAILLGLGFMIFTGQVFLWLEPVAETWEQSKLAFFVLWLCVFFVSFPPLVGWSTFGTVAGFIFGIWKGWLLYATATVLGSTCSFIVSRTVLSKFVNRMMERDKRFAALALTLKYDGLKLLCMIRLCPLPYSVCNGAVSTFPTVHPLMYGLATAIITPKLLVPAFIGSRIRILSEQKGEMSAGSKAVNICSIVLTISIGVFTGWYIYKRTLARAKELEAKERADIRRSLQADHAAHRPHGSFSEDPDVNTAASILARDEEERIGFNDFDDDNVDLVIDDESGSDNSSGQTRKHLQGSYRDEFTDNDSDVFRDGDGADSETYHLHTHVRPN", "function": "Golgi membrane protein involved in vesicular trafficking and spindle migration.", "AFDB_id": "AF-A1CIM4-F1-model_v4" }, { "swissprot_id": "P01070", "sequence": "MKSTIFFLFLFCAFTTSYLPSAIADFVLDNEGNPLENGGTYYILSDITAFGGIRAAPTGNERCPLTVVQSRNELDKGIGTIISSPYRIRFIAEGHPLSLKFDSFAVIMLCVGIPTEWSVVEDLPEGPAVKIGENKDAMDGWFRLERVSDDEFNNYKLVFCPQQAEDDKCGDIGISIDHDDGTRRLVVSKNKPLVVQFQKLDKESLAKKNHGLSRSE", "function": "Inhibition of trypsin.", "AFDB_id": "AF-P01070-F1-model_v4" }, { "swissprot_id": "Q9XGY6", "sequence": "MEVEKELKTFSEVWISAIAAACYCRFVPAVAPHGGALRLLLLLPVVLLFIFLPLRLSSFHLGGPTALYLVWLANFKLLLFAFHLGPLSNPSLSLLHFISTTLLPIKFRDDPSNDHEKNKRTLSFEWRKVVLFVAKLVFFAGILKIYEFRKDLPHFVISVLYCFHFYLGTEITLAASAVIARATLGLDLYPQFNEPYLATSLQDFWGRRWNLMVSDILGLTTYQPVRRVLSRWVRLRWEVAGAMLVAFTVSGLMHEVFFFYLTRARPSWEVTGFFVLHGVCTAVEMVVKKAVSGKVRLRREVSGALTVGFVMVTGGWLFLPQLVRHGVDLKTIDEYPVMFNYTQKKLMGLLGW", "function": "Catalyzes the final step in the synthesis of long-chain linear esters (waxes). Has activity with both saturated and monounsaturated acyl-CoA ranging from 14 to 24 carbons in length, but C20:1 acyl-CoA is the preferred substrate.", "AFDB_id": "AF-Q9XGY6-F1-model_v4" }, { "swissprot_id": "Q6PGE4", "sequence": "MAALQSAPDSPATQLEPAEDGSECDADPEEEEEEEQQEEEDEEEEEEVVVEEVATPVQEVAEVEVEANSADNGGGDDDDDGGGGDDDVEEVLAEEQTLSLGTQERHSNGGHAKAPVLQGKALQTSRVSPTTQDEDVEEEEEEEDEEHFLTQGLVTFEDVAVYFSLEEWERLGVDQRDLYREVMQENYGILVSLGYPIPKPDLIFHLEQGEEPWVEDGPHPEEGDVVTGVYTGAWFWNDDIEDHEEEDDEDFLAEVAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSVQTPEGWGPNPGSLGILAEEVEAKHFLSGREPGENFLVPWAFPAVAVPIGCPETTCDVCGKVFPHRSRLAKHQRYHAAVKPFGCDECGKGFVYRSHLAIHQRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCVFCGAGFGRRSYLVTHQRTHTGERPYPCLHCGRSFSQSSALARHQAVHTADRPHCCPDCGQAFRLRADFQRHRRSGGCTEPSSGDGARMAPHEVGMAPNEVEMAVAAVATVEPEELEAAPAETEEPEAGVADGDTEAEARQDEQVVVAPAAEATVPDSKKDPEPDRRFREMGNGLAEGEGPSSHPFGFHFPMHPKSWLHPDGFPILGFPEFSERLQADGRHLPGPLGSPLSLQGMGLACDPFRSVGPGAGVDGGLRAFPPAVRSLLSEPAPAALAEEESPWICSDCGKTFGRRAALAKHQRYHAGERPHRCADCGKSFVYGSHLARHRRTHTGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTAHGRAHTGERPYACAECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRTHTGEKPFRCADCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERPYLCSNCGRRFSQSSHLLTHMKTHRGPGSAPAHTSSTKAQAPAKATPPLPPPGSGSGTLLEFAGGTSFGSDPAAFAGPSGSYEESIL", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q6PGE4-F1-model_v4" }, { "swissprot_id": "C1A4H9", "sequence": "MRLGLFGGSFDPPHVGHLLVAQDALEALRLDHLLIIPAAQQPLKGAHQTSAHHRLAMVRACFEGVQGIEVDPVEIERGGLSFMVDTVEAVRRRWPDAHLHLLVGRDVVPTLPRWHDVDRLLSMVRLVVLTRDAAPQEGPLLIDAESDSGVVAEVLSTRQVDMSSTEIRSRVRDGRSIRGFVPDAVATYIASTGLYREYPRGSADTERSERA", "function": "Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).", "AFDB_id": "AF-C1A4H9-F1-model_v4" }, { "swissprot_id": "Q2S3R3", "sequence": "MDVEIYQEDGVESGETAALDPTVFDIEPNDHIIWLDVKRIQAHQRQGTSKTKERGEVRGSGRKLYRQKGTGNARVGDAQSPIRRGGGRAHGARPRDYAHDLNQKEKRLARRSALSYKAANDNIQVIENFSLDRPDTRGLTDLFELLGVEGQDILLATAEVEREVYLSSQNLPDVNVQEVQSINTVDILDADVVLLQEGALDWLTDVLSTDEAVPA", "function": "Forms part of the polypeptide exit tunnel.", "AFDB_id": "AF-Q2S3R3-F1-model_v4" }, { "swissprot_id": "P43567", "sequence": "MTKSVDTLLIPGPIILSGAVQKALDVPSLGHTSPEFVSIFQRVLKNTRAVFKSAAASKSQPFVLAGSGTLGWDIFASNFILSKAPNKNVLVVSTGTFSDRFADCLRSYGAQVDVVRPLKIGESVPLELITEKLSQNSYGAVTVTHVDTSTAVLSDLKAISQAIKQTSPETFFVVDAVCSIGCEEFEFDEWGVDFALTASQKAIGAPAGLSISLCSSRFMDYALNDSKNGHVHGYFSSLRRWTPIMENYEAGKGAYFATPPVQLINSLDVALKEILEEGLHKRWDLHREMSDWFKDSLVNGLQLTSVSRYPSNMSAHGLTAVYVADPPDVIAFLKSHGVVIAGGIHKDIGPKYIRIGHMGVTACNKNLPYMKNCFDLIKLALQRKK", "function": "Has alanine:glyoxylate aminotransferase activity.", "AFDB_id": "AF-P43567-F1-model_v4" }, { "swissprot_id": "P18900", "sequence": "MFQRSGAAHHIKLISSRRCRFKSSFAVALNAASKLVTPKILWNNPISLVSKEMNTLAKNIVALIGSGHPVLNKVTSYYFETEGKKVRPLLVLLLSRALSEIPMTERNHLKIDKSDVPEDPIYSKPSQNQLFQRPASSISPLHILHGIKPLNPLTKGPEPLPEETFDKQRGILPKQRRLAEIVEMIHTASLLHDDVIDHSDTRRGRPSGNAAFTNKMAVLAGDFLLGRATVSISRLHNPEVVELMSNSIANLVEGEFMQLKNTSIDADIDTIENGHKLLPVPSKKLEVKEHDFRVPSRQQGLQLSHDQIIETAFEYYIHKTYLKTAALISKSCRCAAILSGASPAVIDECYDFGRNLGICFQLVDDMLDFTVSGKDLGKPSGADLKLGIATAPVLFAWKEDPSLGPLISRNFSERGDVEKTIDSVRLHNGIAKTKILAEEYRDKALQNLRDSLPESDARSALEFLTNSILTRRK", "function": "Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species.", "AFDB_id": "AF-P18900-F1-model_v4" }, { "swissprot_id": "O96612", "sequence": "MKNIEEMPSKSQLVAHRSRGLINTSNTCFMNVILQSLTGCQLFLRVIKNLSDLEDLGKYPTLHSFNQFYTEYFSNPTSNILNNNSNSTTTTSSSSTTATTTSTSNNNKSQTPTSPIQQHHQSQTNGLSNQPSVATQSQQQQQPQPPINPKHFNDLVKSFNSKVSPVPQTTVSPHSMVQVSKKKLKLQLYNNSLPQTICQQDAQEFLVFLLDLIHEEFLTLIKDIDIPKEDDKSTPTSTSIVDDNWEVVGKKGKTAIITNSQQELPKTPISQIFSGVLRSSFNRTGSKESITVEPFYCLHLDIRPEEINSLEDALKFFMKPEIIEGYTCSTKKIEISASKSWSFESLPRILIVHFKRFAFESDTSKKLDKLIRFPTQLSLSTASNHQTQKKYSLFSVVSHHGRGLSQGHYTCDIYQPQQAQWIRYDDSTFTEVKEQDVLNREAYLLLYQLVN", "function": "Required for proper prespore cell patterning. Plays a role in stabilizing mkkA by preventing it from being targeted for degradation. ubcB and ubpB differentially control ubiquitination/deubiquitination and degradation of mkkA in a cell-type-specific and temporally regulated manner.", "AFDB_id": "AF-O96612-F1-model_v4" }, { "swissprot_id": "Q54FD6", "sequence": "MLSAAPKPTPQNKKQSFYNKLWCMVCRIQDPDIIEDYAKGDLICRGCGVVVGDRIVDEHSEWRTFSNSESTGADPNRVGGPINPLLRDSALSTTVGKGSKDSGTLTRLQNKSALGTGDRNLLAAFKEIGRMADHMNLPQTVQDRANELFRFMDDKKSTKGRSVDGMVAAALYIACRQEHLSRTFKEIAALTNVPKKEISRCYKIMKETFASVLNLQTISSEDFTSRFCSTLKLPNDVKKGAEHVSKMAMDMGIVAGKSPISVTAASIYMVSQLSPEKRTQKQIADVSGVSEVTIRNAYKDLYAKRDQLIPSDSPYFSQVQYLPTN", "function": "General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA.", "AFDB_id": "AF-Q54FD6-F1-model_v4" }, { "swissprot_id": "Q8PKT3", "sequence": "MWFAAAPALGSGAAVVFGPPCGAVESEMDEQTLLKKLRWRCRRGMRELDQLFGRYLDQRWAQAPDAERAVFLQLLDCEDDKLWRWFMGYEACPDAANAALIADIRALPA", "function": "An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.", "AFDB_id": "AF-Q8PKT3-F1-model_v4" }, { "swissprot_id": "Q01194", "sequence": "MDMMQFQRQTTQLAMTQRMQESLRILQMSNADLADYLTAQALENPCLEVRVPEGASVAPALPSRGIQAGLDRDAFATVEGQPPSLLAHVEAQIDLAFFDPGDRRTALAFAEALEPSGWLGQPVSEVAAAAEVEEEEALVILERLQALEPAGLFARSLAECLALQLEDLGLLTWELRTMLDHLPLLAEGRIADLARRCDCEPEHIRENLALIRSLSPKPGEAFAADRTPIQPPDVRVLRGPEGWEVELTRAQLPRIRVSEAGDTGDRQADAWLARARSQARWLERAVERRQATLLRTAVCLVRHQADFLDQGPRALRPLSMEEVALELDLHPSTISRATATRLIETPRGLIPLRAFFSRSVSSDGPEAPQSQDALMALVREIIAREDRTKPFSDDAIVKQAKLAGAVLARRTVTKYRETLGIPSSYDRKRAAAAA", "function": "Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the nitrogen fixation genes. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein NifA for the expression of the nitrogen fixation proteins.", "AFDB_id": "AF-Q01194-F1-model_v4" }, { "swissprot_id": "Q9PQW5", "sequence": "MQNLNNKQKTLIIFLGIITFGIFIIYFFTKAKKVSQIRNTHLIVSSNIPFSLNDFYNCIGSKNNLVNVDATINTLKIELKEINALNNEKLKVLGAKGIMCNQTKISIIFGDFCLELKELIKKDLFS", "function": "The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.", "AFDB_id": "AF-Q9PQW5-F1-model_v4" }, { "swissprot_id": "O18280", "sequence": "MTITASNTLEFKWTSPRSSRSSFRTTTDAEQKISIDMSNTYCDQVLGPLYSYMMVLGLNHTHSSARNTMFKWPLTIYNYLTLAILTAATIRRISQIKQKSATNEEKDAAFHVLNPTFVLTLCHALLMFSGLAAGFLLLKLQKQREKMYHVLDQGLGRNRNEEHDSHHFKLNKLFISISFSFAAALSFVQIATKMRYLDLPDTPDLINRKIYFVILEGYVIFIASSCISLVAILFFQLCRILQFSIGQLIEEMVPKEKEECPLPEQSLQQIHDVQIHYQEISNAKLYIEQNFSFSLFYTYGCCIPLTCLLGYIAFRNGIQADMAETFSVAIWLTNTMLALMLFSIPAFMIAEEGDKLLTASFKMYHETLCEERDLLVLSQMSFLSFQMHATKLTLTAGNFFMMNRKIMISLFSAIFTYFLILVQFDAEKERAGECNNQSRVLIVQPPV", "function": "Chemoreceptor involved in light-induced avoidance behavior. Probably acts as a molecular sensor in I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide. Involved in circadian rhythms, probably by acting as a light sensor. In contrast to lite-1, does not act as a photoreceptor.", "AFDB_id": "AF-O18280-F1-model_v4" }, { "swissprot_id": "P0AGE7", "sequence": "MSEKLQVVTLLGSLRKGSFNGMVARTLPKIAPASMEVNALPSIADIPLYDADVQQEEGFPATVEALAEQIRQADGVVIVTPEYNYSVPGGLKNAIDWLSRLPDQPLAGKPVLIQTSSMGVIGGARCQYHLRQILVFLDAMVMNKPEFMGGVIQNKVDPQTGEVIDQGTLDHLTGQLTAFGEFIQRVKI", "function": "Catalyzes the reduction of quinones. Acts by simultaneous two-electron transfer, avoiding formation of highly reactive semiquinone intermediates and producing quinols that promote tolerance of H(2)O(2). Quinone reduction is probably the primary biological role of ChrR. Can also reduce toxic chromate to insoluble and less toxic Cr(3+). Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen without producing the toxic Cr(5+) species and only producing a minimal amount of reactive oxygen species (ROS). Chromate reduction protects the cell against chromate toxicity, but is likely a secondary activity.", "AFDB_id": "AF-P0AGE7-F1-model_v4" }, { "swissprot_id": "P40362", "sequence": "MTMATTAMNVSVPPPDEEEQLLAKFVFGDTTDLQENLAKFNADFIFNEQEMDVEDQEDEGSESDNSEEDEAQNGELDHVNNDQLFFVDDGGNEDSQDKNEDTMDVDDEDDSSSDDYSEDSEEAAWIDSDDEKIKVPILVTNKTKKLRTSYNESKINGVHYINRLRSQFEKIYPRPKWVDDESDSELDDEEDDEEEGSNNVINGDINALTKILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.", "AFDB_id": "AF-P40362-F1-model_v4" }, { "swissprot_id": "P40080", "sequence": "MINEYVARKVALKDMQPCAICSKPSTTVLYNASGPDWLYTCEIHLQDNPQFVIPLYSTEYNEAVAQLKLVKGKMDSLTSAQTQLGSWDGWVTKIFSKKEKETNNSKDPDPTTTDSTDTSPQAKNDAEILSETKKQYSKILDKVTELQRKNRKYELAKIMFESRLLRKRTEQVNRERYLKEQENYSNTDPEELLRKHVFPSVPK", "function": "VPS4-associated protein involved in trafficking to the vacuole.", "AFDB_id": "AF-P40080-F1-model_v4" }, { "swissprot_id": "C0Z274", "sequence": "MGMASMSSGTESLRLCVFDLRRGQHEGQELDKILFFYPPDLTFSTQLSVIGLSEGLITFTRLFSPEAACEVIEAERHSHVFYEAEPDIWMVMIVEKNKEIEAVWRIDALRRVLKEVHSLFVMFQGSIRALLEKEPTGGLVRSHLYPFITDYLNDLFVGKKQQLPSFRDTLKERGTVQMLTLARDAALEVQSLVGVLDSCAGTVRCHSVILFHDLLVSTTLSPDDTVDLFAFSVMRLTTNALSSGTSSWSYLRKGSGSPQISSRSTTVPPLGSGGTLPSGNGSSTGRVIRPLQHDKWSKGKDGFLVTDIWGLDATPTILIQKTQESFYLLTYQYKSLTLVLLVPIAAIVNGELDISFVKQQVIENASTKILKVEEKLSKGWGGENAYHVSGYRYLLVDNDMEVSRASPPGKVATLAKESLLALNKLREEVDTEKNRSKQEKDMEICIRAKNNTWVIARLNRGKELYMALEKASETLLDATDSVQRFSNRYCSGAFPMD", "function": "Plays an important role in membrane trafficking through the secretory apparatus. In complex with MON1, acts as a guanine exchange factor (GEF) for RABG3F of the RAB7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.", "AFDB_id": "AF-C0Z274-F1-model_v4" }, { "swissprot_id": "Q9BWV1", "sequence": "MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQSDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQRQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWCPQHPVGAYVGQEPGMQLSPGPLVRVSFETPPLTI", "function": "Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.", "AFDB_id": "AF-Q9BWV1-F1-model_v4" }, { "swissprot_id": "B8I5U8", "sequence": "MSRWKIYTPDGVQDILFDECYKKREIEKRIRNTFRSYGYYEIETPTIEFFDVFSSEIEHFPQESMVKFFDQKGRILVLRPDITVPVARITATKNRDVQVPIKYSYIGNVFRFNEVGGGRQNEFTQAGVEMLGDSSSESDAEIIAMAINTLKSVGLKEFKIEIGQVEFFKGLAEEAGFSNEDIDAISKQIDKKDLVGVEEILNRYDISTELREIVLKLTGLFGSVDVIKEFKKASINGRSLKAIENVEEVVSILCDYGLSEYVSIDLGMLKSLNYDTGITFRGFTNGVGFPILSGARYDNLTSSFGKECPATGFSLRINMLMTAMEKAGHTFERPSVDSLVCYEKTNRKRAIEIAEALRKQDMKIETFVLTKGIDQAKKYAASKKIGGIIYIRDNDKITVYDIKNNITEETSFDTLLNNQ", "function": "Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.", "AFDB_id": "AF-B8I5U8-F1-model_v4" }, { "swissprot_id": "Q9VWY6", "sequence": "MEKVEAVTVSNVDPYRRILNKVVSQLLLDKGAGQASNHSLETLTQMLQALIWEIGNSAHNYCELSGRTMPTVGDVSLALINMGISISNLDPYMRKETHVPIPLPPQQTQQRPLSLLQAGIKAPHPHYVPSYFPPMPDPHAYIRTPTHKQPVTEYEAIREKAACQKRDIEKALTKFLCKTTETNNLFPTEDNMFPLIACKPAFPPYAAALNPTDQVFDFEELEYHYLVANRTEDEPSKDDGEEGDSENEEMDGDKSKEEKPELDIKPNSNTNKAILENPNIDNPYLRAATLPKRSKNCPTPGTMPSRSLATTAPTIRTPSTLEITKTNL", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.", "AFDB_id": "AF-Q9VWY6-F1-model_v4" }, { "swissprot_id": "Q8IV56", "sequence": "MADSGDAGSSGPWWKSLTNSRKKSKEAAVGVPPPAQPAPGEPTPPAPPSPDWTSSSRENQHPNLLGGAGEPPKPDKLYGDKSGSSRRNLKISRSGRFKEKRKVRATLLPEAGRSPEEAGFPGDPHEDKQ", "function": "May have a role in proliferation and/or differentiation.", "AFDB_id": "AF-Q8IV56-F1-model_v4" }, { "swissprot_id": "Q86YD3", "sequence": "MALPPGPAALRHTLLLLPALLSSGWGELEPQIDGQTWAERALRENERHAFTCRVAGGPGTPRLAWYLDGQLQEASTSRLLSVGGEAFSGGTSTFTVTAHRAQHELNCSLQDPRSGRSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTSASLPAPGLLATRVEVPLLGIVVAAGLALGTLVGFSTLVACLVCRKEKKTKGPSRHPSLISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDSRAVKPADRQMAQNNSRPELLDPEPGGLLTSQGFIRLPVLGYIYRVSSVSSDEIWL", "function": "In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.", "AFDB_id": "AF-Q86YD3-F1-model_v4" }, { "swissprot_id": "Q556Z0", "sequence": "MSKNGTTGNKKKKTKLSTAATIAANIAKANATLNNNNNSNNNSNNTNIGNSINGIPSSLPPSVTLPVEELISFAPECLLFSQLLEFEEKLDASINKRLIDIQEASRRNSIKNIRTLRLSIYNTYSNQSAYYHLDNKSLNSVQERPSWSLRVEGKLLDESQDELVNKSIKSSSSSSSTANKRKFSSFFKKVFIQIGHRDTCEWDKSQTFTETDGFEIKRNGNQEVDIKILMYLDHVPQKYKVLGGLSQLLNIHTDTKPRIILALWHYIKSNTLLDAETKKITCDENLKNIFSLEELQFNQIPQLLREHLSPPDPLEFQYTLHLSGDAKDYEQAYDIQVEVDEPIFNPNPTMRKEISQLNDEINHHIQKVYQHKRKREFMEKLSSDPLGFLNDTTANLVKDFQVSKSTTSTGFEEERHASFYYQPMTEELVKNYLSKQTTPNPTPQQISMAPSTPQTP", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).", "AFDB_id": "AF-Q556Z0-F1-model_v4" }, { "swissprot_id": "Q8NI77", "sequence": "MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHHLHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSKCKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNSSLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR", "function": "Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.", "AFDB_id": "AF-Q8NI77-F1-model_v4" }, { "swissprot_id": "P23226", "sequence": "MEHHEDNAQLDNYLQNRLAESLQICGGAGEHNPHLADATGGNGCAPGIAPSKSDEVDGEEDEEWKYIHEVRQSEKLQQEKLPLTKETGNGFGPGRDSDNQVHGNGAAAVFNLYEEDVEVIKNDGDFSTNSNTTTSTDEVVARQAQEPNQLPEQLQQQQQIESQGVHEDPRQEDEDEHSSVATTYGTSSLSENNSSPLDQEEVVMVAQTVGQEQLVDFDNKENSYFVKNLEENHSQLNPNAVAFVPGVGSQSSSPLPAAEDPLPGVQPRPFLPGGTLDDLVAESPRKEFARINMDGIAVPDEREFDIEADMRPHELEQESDTFGAGHLEMQLLNGIGTADQAALRDVLDHGPETSVDMELPLDQVPNDADIMKQSIYAEHNSSIEDILNSVQPLPIQTCDDKELIHVEEKEHVSKSPSTEELQFQSDFPNNQESHTLFNNTEQDPMQASFYLEHTSQKAQEGCQEQMQLPAECSDIFADQSLLLDTSAPQLSSEADSPVAKLELESQQAGIVDITPSPLSSTAEKHLVEDTKELVEEYTLDPESHFFGVVSSQAPLQLFGKHTLPSIIHSCKHRVASEQNDEENAVFESVSGYETQNFDEISSPPEGINPFAQPFTPAHLVIEQANTMMEDVGGMPIPASEDFAICDKVASKSSNEVEDHRSEQQAFVKEELLHPVGDVVAQVENLGTEKNFVVEEERLPISVSDEIPLSSASKEKLLPDTTDEQLLTSALEEKLRSVAPEESVSTAADGQSISQFDEYVIASNKPLEDILEPEKDVEVAKSLSEKTSVATVAGGAVVGATKTHSATKAGSTAASAKSKTETLVMKKTTASSTSVYGANKSAAPRPSTARLGIKSTSIATKTSTTSSLTGNPRKSLSSNVGSTVKPPTKLSGTRPATAPVSKVTLGAKTITNKPTASGTASDNVTRTTLRPLVSTNARRPATSGTGSVASSTARRPVTNAKGSAPGSAASTKVRPAATMTAPVKPKVLSPRSTISSTTTVRKVPSTSTPSFSTRSPNKQQSNGLGKNTSSTTTSTATATITKSFTARSAPKFTHSASLTYNNGSTSRRLLVPGSSSTTTTSSLRKSSPLKAAPGKAASKPLTPQSKDGTAKSSPAVLKARNSTLMGGEGVAPSNECVPTPNGQINAEEVVKLKGKGLAEEVKIIEEQKLHEQDVPAHNAEVPLLDF", "function": "May play an important role in the regulation of microtubule assembly and interaction.", "AFDB_id": "AF-P23226-F1-model_v4" }, { "swissprot_id": "P39907", "sequence": "MWEKCHRQWHKIKFYVKHAHLGLLPPAWLAKSAAAELERFERAPAELRAAIENRVHYYNALSQPFFLPETAPRVCHFPRQKPSSYYYDLKALLRYFPLEQRFSAQFGDVTTIPELPQFVKSRPITKNNENAVLLKLDSVRHFYLYPDRLPFRAKKSQLVWRGAAHQNHRIRFLEHFHQHPLCDVGCIHARSAAKPYHREFMSVKRQLQYRYILSLEGNDVATNLKWIMASNSLCLMPAPRYETWMMEGRLQAGVHYVQLRDDFADLEEQILFFERYPEAAEAIIKNAQQWMSQFARPETELWTALLVMKKYFSLLEPQ", "function": "Involved in lipopolysaccharide core biosynthesis.", "AFDB_id": "AF-P39907-F1-model_v4" }, { "swissprot_id": "P94370", "sequence": "MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPDLSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEETIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTVKSRVHKGLQQIRKEWDDE", "function": "Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Positively regulates the expression of the sigY-yxlCDEFG operon upon nitrogen starvation. Also positively regulates ybgB.", "AFDB_id": "AF-P94370-F1-model_v4" }, { "swissprot_id": "Q9VQE9", "sequence": "MHTPKCRRPSMSATLSHKDLAGLAGCSALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVLSFRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLPSRMGVLAAGALFAVHPAHTEAVAGLVGRADLASCVCYLLAYLSYRRHMLNREWGSLILTIMLALAALLCKETAITALLLCGLCDVLSPVGRENSDKVCDGSISGLASFNFQRRFRSLSILGFTLLCGLYCRLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQLSAPSYRSASAIYSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPSVGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDYTLQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQPGHAISRANLARMNVHKHENE", "function": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.", "AFDB_id": "AF-Q9VQE9-F1-model_v4" }, { "swissprot_id": "Q01846", "sequence": "MPKFPQFRLILVLFYLISMIQWSVITFSLGFFLNVCIFAYFVFFKSLPDLPKPQPRFVDIVPESSNTVDVDKELKSVEGLIQDGNAQIGKELESIVNLIIKDFVQPWFTKIDKNSDAEFLKVIKWRLLQTLLVVKDKLMKNDSASLIVLKLLPIFNKHFSTFCDAREAVLSDLTLERHKSANIDLQIAVEFNKNYKIHKSLSLKPNALQKEIEKSIRKTVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIFKFTDPDSWNLRIVSLSQNYFEEKHKVHKIRRMLSKELQDHRKVMNDVANKDVGEPSSEKLELNAEYTGKQFEHYLNQLDSLLDLSDIKYVAYSLALKIYQLKENEHLTKENLKYKKRLLLSLNLIESKLSFPGSEIDTASKKLAREANYPDLNMDNGIVLKEMASFLTSITLKDIVDDSEFLPFFESFLGSVPETQGSTFLEYSQTIESFKNPLEDATSEDIISGYSGISTMQLQEISSKFFHNNNLQNMKLLDEGLVKNIILFRNSFQINNDEDTFILARKSVLLLQTEAIKYLDDRFLPLFKKTPSFLKMLSTSHIISTDIYAHFLSRIGGVNNPEQNKIIKDNVKTDFMNPVRIFANPGITDALDNIVNGSGSKPHKSRISSNPRYSQLFGSENDNIFKDKLFDDENDNTSEISVVEDQLDHPRNMEKVSVSSGNSGLNPSQFYGSNNFRDNIASLTISIDQIEKELELLRHLILKADLTNNQMQLKILKKSQRTLLKELEMKELLKQQYMVQENGNSLFRKTKIYIRSYFSENSSNGLKEITYYIINIHHFNNGQVSSWDMARRYNEFFELNTYLKKNFRDLMRQLQDLFPSKVKMSLKYHVTKTLLYEERKQKLEKYLRELLSISEICEDNIFRRFLTDPTPFKLNKEYMHDDILEEPLHEPIGSSNSTSNSSSVVDLQSSEDGGELNFYEDERHFFTDSGYPFYSQNKSFVKQICDLFISLFALNKANAGWLRGRAIITVLQQLLGSTIEKYIKVSIQKLRSEDQVFEAIVTFKNMLWGDNGLFERKRNETAEATRSEGERLRTEQLALTSLQRLFADTCGRVVGLRDSHEAAGRVHAMLQNPYLNASLLLEALDAILLDIICND", "function": "Essential for mitotic growth. Mediates organelle inheritance.", "AFDB_id": "AF-Q01846-F1-model_v4" }, { "swissprot_id": "P26797", "sequence": "MAFNIESLLEKKSNPVEEGNDFEEENDSEKNGEEDEEEEEKNVIDGWTNMATSQLAMFAIANDLRTPTLVELQMLLGVSARKHDYKRSRKSVCERKPRQAYSARQLDRLETEFQTDKYLSVNKRIQLSQTLNLTETQIKTWFQNRRTKWKKQLTSSIRQMVKDAPTSTSVGVPFQSLLTPPTPPTTLACHVNSLFACEQ", "function": "Probable transcription factor. Required for MC motor neuron differentiation and function, including role in modulating pharyngeal pumping. Regulates gene expression of FMRFamide-like neuropeptide flp-2 in MC motor neurons. May act downstream of transcription factor pha-4.", "AFDB_id": "AF-P26797-F1-model_v4" }, { "swissprot_id": "Q9SX97", "sequence": "MPSEPNQTRPTRVQPSTAAYPPPNLAEPLPCPRCNSTTTKFCYYNNYNLAQPRYYCKSCRRYWTQGGTLRDVPVGGGTRRSSSKRHRSFSTTATSSSSSSSVITTTTQEPATTEASQTKVTNLISGHGSFASLLGLGSGNGGLDYGFGYGYGLEEMSIGYLGDSSVGEIPVVDGCGGDTWQIGEIEGKSGGDSLIWPGLEISMQTNDVK", "function": "Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.", "AFDB_id": "AF-Q9SX97-F1-model_v4" }, { "swissprot_id": "Q6XQ84", "sequence": "MFSLQHVLLILISLGQVYSQQVHHNAGRKFPQWLTGLIAMTVFLFLVLVVYVAKMFWDKRSQESINMKDIEEVVANGTSECCEARKENQYISCNMKDLRSSEHIHAYENPIEVNDNVRSTAM", "function": "Essential for pronephric tubule development, acting upstream of pax8 and lhx1/lim1 and downstream of retinoic acid signaling to induce pronephric mesoderm to form pronephric tubule-specific cells.", "AFDB_id": "AF-Q6XQ84-F1-model_v4" }, { "swissprot_id": "Q48725", "sequence": "MAFLPRYYPENIEYLKISKENTPLKEWYIPMTCFCDIPLHQMSYHAEGKAQTGYGKFSIALHKKFGINNGIQPVQYLNSNSIPTEELRNAISILLSDNGQIYSDEALISLSNHLFEYMRRIKPLDGSMKKWDKEGKKYVEIKKNFHDEHEWRYIPDFESDELPFLLYRQDDIIAESSSQFYTKSITETKNGLLNFSVSDIRYIFVDSILSREKLISFIKRKQKGKRIPRAEKDILISKILVYDEIKEDW", "function": "Confers resistance to phages by a mechanism of abortive infection. Seems to act by interfering with phage RNA synthesis. Does not act at the level of phage DNA synthesis.", "AFDB_id": "AF-Q48725-F1-model_v4" }, { "swissprot_id": "Q6BET5", "sequence": "MNVITPPFADGVDPKPVCIVADDIFETMTARRKIHFSIYVIFKKNVELAEPFKLLYYTEKKNVAHLDGSVAQDFGLPMWTKDDGQRAPDLSRQKNDYIKLDFFTNINNPEDGFSYCWTDCISTKNTTMVPRQLMPPSKRSMKLYLILPVEESNIMVLSEKAYGSLQLMKKHRKMGQPPQRVGCYINFNCQTSKVMFGCGHVYCEQCLNSWNDKPCSVCLKPVTSEPTQLKLRQGPCPFDLCSPNSSTMGIVLIPCGCHVMCQNLEDAYERNKHHLEPLIEKIKYCPFEPCRIRVRKLKKPFWHQQDKEHTLEMNSA", "function": "In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets.", "AFDB_id": "AF-Q6BET5-F1-model_v4" }, { "swissprot_id": "Q09607", "sequence": "MPHFKFYYFDVRGRGEAIRLLFHLADEKFDDERFGMEQWGVLKSEMPLGQVPVLEIDGVKISQTTAIARYLGHQFHRAGTNAVDCARLDMIAEVIQEFMSSSGMGKFSRVLLGMIQANKEQFFKENVLPDVEKYAPIVEKFLLENGNNGLLLGDRETWVDVFAAESFSKLIDYGSPDALDAYPHILALINRVFNHPNIKKYVSQRKATPA", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.", "AFDB_id": "AF-Q09607-F1-model_v4" }, { "swissprot_id": "A0A089FNE5", "sequence": "MAQSFANEHDPAKRAEERGHVGTIEDVESGTKEPYIAEEPISAEAARALIWKQDKRIIPLSAAIYFLCYLDRSNIGNAKILNAATGNDLLTETHMTNYDYTIALMIFFLAYGLFEVPSNVLLKKLHPSRWIAILMFSWGAISMGLAGAHNYATVTVVRFLLGIFEAGLFPGLVYYLTFWYKTEERSIRVAFILASATLAGAFGGAIAYAVGHMNQAHGISAWRWLFIIEGAPSCVSALFVLFFLPDYPETVNWLSDEERELALRRLRVEGSKGLHQSDWWKDAKSTLVEWRLWAHYLIYFGISTPFSSLSLFTPSITAGLGYDGLQAQLMTVPPYAVAYVVQILVSWSADRTNSRGLHSAASATVGACGFLASAVLPAEAYLHRYGCLIVAAAGAFACIPPLLGWLSSNIFSTASVGLAIALNIGLGGAPGQIAGVWIYKADEAKKGYPTGHWVNAGLLFFVAVACVALRLHYGFRNRKTVRETGGIEGVRLFKY", "function": "Efflux pump that might be required for efficient secretion of pyrrolocin or other secondary metabolies produced by the pyrrolocin gene cluster.", "AFDB_id": "AF-A0A089FNE5-F1-model_v4" }, { "swissprot_id": "Q9R1Z8", "sequence": "MARILGVGRSSASSLNNKEDNESDVALLSPKDPNRVHTKEQLAHPASSNLDPSMQGLPAGLSLDDFIPGHLRTHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGCPPPRRDGSLNPDPAWYQTWPGPGSRPSMSPKPPASQHAQNWSATWTKDSKRQDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFQQIHRKMPDLQLDWTLEDPPKVVSARASSAEPRHLGTLQRPASRPGTTETSSGRNWNHSEETSRNTFNYNFRPSSSGLHPPNQVPRHREKVENVWTEDSWNQFLHELETGHKPKKPLVDDPVEKPAQPIEVLLERELAKLSAELDKDLRAIETRLPSPKNSQAPRRPLEQPGLEQQPSARLSSAWRPNSPHAPYFSSSRPLSPHRMADGGGSPFLGRRDFVYPSSAREPSASERGSSPSRKEEKKRKAARLKFDFQAQSPKELSLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGDAVAQYTFKGDLEVELSFRKGERICLIRKVNEHWYEGRITGTGRQGIFPASYVQINREPRLRLCDDGPQLPASPNPTTTAHLSSHSHPSSIPVDPTDWGGRTSPRRSAFPFPITLQEPRSQTQSLNTPGPTLSHPRATSRPINLGPSSPNTEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV", "function": "Promotes up-regulation of actin stress fiber formation.", "AFDB_id": "AF-Q9R1Z8-F1-model_v4" }, { "swissprot_id": "Q1MJ94", "sequence": "MLERITRSITSASIFLAAYFLLNIALRIALPHTLDLDEAEQSFYSQYLLAGYGPQPPFYNWIQYAIVSVTGISMWVLSVPKNIILFGCYLFYGLAAREVLKSRSLAALAMLSLITLPQVGLMAQRELTHTVALLFATSLFLFGFFRTLRQPTIGSYLLIGIATGIGLISKYNFAILPFAALIAVLPEREWRSRLIDWRLLPAAVLAILIVLPHALWLPDNLASASAPTLERMTAEHLAPAGLPRIGQGLLSLVIAVLGFVALPIVLIAAAFRRDFFRALSSSSPMIRVIERMMVISLLAFVGVVLFAGASDIHERWLDPCLLVLLIYLFLKLETADIDLSAGLARFRPVVPVFMVVILSILLFRIVGIQYIGTYTRTNVPFSGYVAELTATRKPVLIVAGTKFIAGNMRLQFPDVPVVIPFFPGPGVPEYADAKGPVLVIWRGETADDPTISPGFANDLVKSGIHLPELKTLTLPYLFGDGKRSFSIGYSWVEGGAK", "function": "Involved in the modification of the lipopolysaccharide (LPS) inner core. Catalyzes the transfer of a galacturonic acid (GalA) residue to the 4-position of mannose residue of the LPS inner core, using dodecaprenyl phosphate-GalA as the donor substrate. Seems to act after the other GalA transferases RgtA and RgtB.", "AFDB_id": "AF-Q1MJ94-F1-model_v4" }, { "swissprot_id": "Q59RA2", "sequence": "MPSAKSSDLSPTKTNLESTTKQKVSVQDIFLYIPNLIGYLRIITAIISFLCMANHPVATLIFYGISGFLDAFDGYAARKFNQGTRFGAVLDMVTDRCATSSLIVYLGVLYPQYTVFWQILVSLDLSSHYMHMYAMLSAGSTSHKNVDETQSKLLSLYYNNRLVLFFVCLINELFYMAVYLHYYKFFWLGTVMLVASTPIWLFKQIANIIQLKNASLILARMDAHDHSKRD", "function": "Catalyzes the synthesis of phosphatidylinositol (PtdIns). Required for proper membrane dynamics and cell wall integrity.", "AFDB_id": "AF-Q59RA2-F1-model_v4" }, { "swissprot_id": "A2TJ54", "sequence": "MAQAGGAGAGAWGRRGAGAGAGPERAPWRWAPALLWLAAATAAAAAAGDPSRRQWPVPYKRFSFRPEPDPYCQAKYTFCPTGSPIPVMKDDDVIEVFRLQAPVWEFKYGDLLGHLKIMHDAIGFRSTLTEKNYTMEWYELFQLGNCTFPHLRPEMNAPFWCNQGAACFFEGIDDNHWKENGTLVLVATISGGMFNKMAKWVKQDNETGIYYETWTVQASPKKEAEKWFESYDCSKFVLRTYEKLAELGADFKKIETNYTRIFLYSGEPTYLGNETSVFGPTGNKTLALAIKKFYYPFKPHLSTKEFLLSLLQIFDAVVIHREFYLFYNFEYWFLPMKSPFIKITYEEIPLPNRKNRTLSGL", "function": "Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.", "AFDB_id": "AF-A2TJ54-F1-model_v4" }, { "swissprot_id": "Q9LDX1", "sequence": "MSSRAGPMSKEKNVQGGYRPEVEQLVQGLAGTRLASSQDDGGEWEVISKKNKNKPGNTSGKTWVSQNSNPPRAWGGQQQGRGSNVSGRGNNVSGRGNGNGRGIQANISGRGRALSRKYDNNFVAPPPVSRPPLEGGWNWQARGGSAQHTAVQEFPDVEDDVDNASEEENDSDALDDSDDDLASDDYDSDVSQKSHGSRKQNKWFKKFFGSLDSLSIEQINEPQRQWHCPACQNGPGAIDWYNLHPLLAHARTKGARRVKLHRELAEVLEKDLQMRGASVIPCGEIYGQWKGLGEDEKDYEIVWPPMVIIMNTRLDKDDNDKWLGMGNQELLEYFDKYEALRARHSYGPQGHRGMSVLMFESSATGYLEAERLHRELAEMGLDRIAWGQKRSMFSGGVRQLYGFLATKQDLDIFNQHSQGKTRLKFELKSYQEMVVKELRQISEDNQQLNYFKNKLSKQNKHAKVLEESLEIMSEKLRRTAEDNRIVRQRTKMQHEQNREEMDAHDRFFMDSIKQIHERRDAKEENFEMLQQQERAKVVGQQQQNINPSSNDDCRKRAEEVSSFIEFQEKEMEEFVEEREMLIKDQEKKMEDMKKRHHEEIFDLEKEFDEALEQLMYKHGLHNEDD", "function": "Required for post-transcriptional gene silencing and natural virus resistance. May bind nucleic acids and is essential for the biogenesis of trans-acting siRNAs but is not required for silencing induced by IR-PTGS. Involved in the juvenile-to-adult transition regulation. In case of begomoviruses infection, it is targeted by the viral protein V2 leading to suppression of post-transcriptional gene silencing. Involved in the mechanisms necessary for quick response to heat and subsequent heritable transgenerational memory of heat acclimation (global warming) such as early flowering and attenuated immunity; this process includes epigenetic regulation as well as post-transcriptional gene silencing (PTGS). In response to heat, HSFA2 is activated and promotes the expression of REF6 which in turn derepresses HSFA2, thus establishing an heritable feedback loop able to trigger SGIP1 and subsequent SGIP1-mediated SGS3 degradation; this prevents the biosynthesis of trans-acting siRNA (tasiRNA) and leads to the release of HTT5, which drives early flowering but attenuates immunity.", "AFDB_id": "AF-Q9LDX1-F1-model_v4" }, { "swissprot_id": "Q4WNV0", "sequence": "MHLLQCLLSTISLASTVTAFVPYSFNLEVSTEGPPSNDVARRFVPWKLLLDDSYNNHGSSSNGVSLTLDLKKFPVRRDNKYKVVLADEPTTPNTAALNQEGLDYSYFATVRVGSQGQQMWLVLDTGGPNTWVFGSDCTTVACQRHETFGEAASKSLKLLPLNWAVGYGTGLVSGVLGTDSLSLAGLDVNMTFGLAKNASTDFESYPVDGILGLGRSANSNFNTPSFMETVATQRLLKSNIIGFSFSRNSDGARDGAANFGDLDTTRFTGDIVYTNTTGDSNNWRIPLDDASVNGTPCRFVNKTAVIDTGTSYAMLPPKDATVLHNLIPGAVTTSHGQNFTLPCNSTAVVQVSFSGLSYNISPKDYVGPAYGSACLSTIVGQALYGDDVWLLGDVFLKNVYSVFDYDNHRIGFANRSVPIASPTTTVAAAANPSATDGAGSTLTGSMAVHTGSASIVSRFVHWPFIFALLCMVLV", "function": "Secreted aspartic-type endopeptidase which is secreted and contributes to virulence.", "AFDB_id": "AF-Q4WNV0-F1-model_v4" }, { "swissprot_id": "O14057", "sequence": "MDGHTCDVFVGKLIHTPSLGELEITDATVGVYNGKIVFLEKSMTPKTLEEAKSHHLLKEATIHKLKPLQFMFPGLIDTHIHAPQYPNSGIGIDVPLLQWLEKYTFPLESSLADLEEARQVYKRVVERTLSNGTTFASYFSTLHTPTSALLAEICYSYGQRAYIGKCNMNNLSPDHYCEKSAESSLEATRQLISYMSILDPKREMVTPIITPRFAPSCTEDLLSGCGELAEKHNLPIQTHISENTSEIELVKELFPERKSYADVYDYYKLLTPQTILAHAIHLEDEEIELLTKRSSGISHCPTSNSILASGLANVRKLLDSGINVGLGTDVSGGYAPSILIALRHAAMTSRSLSYVLGDPKVMLDLSELLYLATQGGAEVVSRGDQVGSFAVGKYWDALIVDLSAETHSCVDIFERDTWPVMLSKWVFTSDDRNLAQVWVNGRLVSGFEMKANLKNSTPLTNGVTSSGHQVFKELTQAHLLPRTQCVDTPPSCCGGHCCKEESCRTENCKGAYPANATVTVEEDSGMS", "function": "Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.", "AFDB_id": "AF-O14057-F1-model_v4" }, { "swissprot_id": "A7NI92", "sequence": "MHYHIVGIAGAGMSAIAHILLDQGHTVSGSDLQQNTLTAALEQRGARIRYGHEPAFVGDADRLVATSAVQDEHIELVEARKRGIPVLRRADLWREWSHGRQVVAVAGTHGKTTTTALIALMLTRAGIAPGFLIGGETPDLGVNARWGNPAAPLVVEADEYDRTFLALTPDIAIITNVEWEHVDIYPSPDEYEAAFRTFARQVAHPQRLIVCGDNAGARRVVGHPDAQQYGIEEAIARNPASCRLALMDWMAANVRYDGSMTHFDLWRYDRRTCGTRLEGMYTMRLVGDHNVQNALAAIAAATTLGIDRTAIGAALAEYRGARRRFDIKGEVNGITVIDDYAHHPTEVRATLAAARARFPQHRIVVYLQPHTFSRTYAMLDNWTHAFDAADIVRIGDVYPARETGEPRAAARALAGRIAHPDVEVVGDVATATATITALLQPGDLLLTLGAGDGYRVGEMALLALGQADDQSESSET", "function": "Cell wall formation.", "AFDB_id": "AF-A7NI92-F1-model_v4" }, { "swissprot_id": "Q02335", "sequence": "MVETTGISDQTKKVLIGVAAAATVAGVGYLVYKSFGGSDLERDLEEIKALGNLKFKEKQYDSALEAFTKGVEKAGPNSSDQIVAMLYQNRAACREKVGHSPFDILNDCMAALKVDKKYTKAYLRAAKALNDVGKKQDALAYLLAAFTLDSSLNKTNFEFFGKLLAIEPMSDCHIGKPLKIEDVKPQPVALFRIQQWCDTWDILDLFKTDLTRFEPEVLSEDQKQYQLALEKFKKGKYEELIDLLTEENSYPPAMILRGKMLSYSTDPNEATRYIDKVGAKINELIGSEEDEERKKLMRDAFDILKIELMYTMADLDKFLESVPKDDKERLFKLYSFASIFVVIRLNHFYSLKIWFQYNGCVLDTAVTNHEQQMMADTNNANRLLTEAEKNGTLTPHLSMIVTFLKLCTSEDYADVHRRIREMEELAESRSTHFNLVLMSKVYMMTNNEESSKKLLEEAARITTRYLVPSRHLQTADLHVHKPEAERLRLTTESANAAIAVDPFNFSAHVLHLLGTNGPEPMIKKENYERAMESIRNAALFAPPRELLMLKRMIPLMNAKKRAAEMLDMY", "function": "Receptor that accelerates the import of all mitochondrial precursor proteins.", "AFDB_id": "AF-Q02335-F1-model_v4" }, { "swissprot_id": "Q8GZN1", "sequence": "MLGNQSADFSEKGEDEIVRQLCANGICMKTTEVEAKLDEGNIQEAESSLREGLSLNFEEARALLGRLEYQRGNLEGALRVFEGIDLQAAIQRLQVSVPLEKPATKKNRPREPQQSVSQHAANLVLEAIYLKAKSLQKLGRITEAAHECKSVLDSVEKIFQQGIPDAQVDNKLQETVSHAVELLPALWKESGDYQEAISAYRRALLSQWNLDNDCCARIQKDFAVFLLHSGVEASPPSLGSQIEGSYIPRNNIEEAILLLMILLKKFNLGKAKWDPSVFEHLTFALSLCSQTAVLAKQLEEVMPGVFSRIERWNTLALSYSAAGQNSAAVNLLRKSLHKHEQPDDLVALLLAAKLCSEEPSLAAEGTGYAQRAINNAQGMDEHLKGVGLRMLGLCLGKQAKVPTSDFERSRLQSESLKALDGAIAFEHNNPDLIFELGVQYAEQRNLKAASRYAKEFIDATGGSVLKGWRFLALVLSAQQRFSEAEVVTDAALDETAKWDQGPLLRLKAKLKISQSNPTEAVETYRYLLALVQAQRKSFGPLRTLSQMEEDKVNEFEVWHGLAYLYSSLSHWNDVEVCLKKAGELKQYSASMLHTEGRMWEGRKEFKPALAAFLDGLLLDGSSVPCKVAVGALLSERGKDHQPTLPVARSLLSDALRIDPTNRKAWYYLGMVHKSDGRIADATDCFQAASMLEESDPIESFSTIL", "function": "Calmodulin-binding protein essential for pollen germination, but not necessary for microsporogenesis or gametogenesis.", "AFDB_id": "AF-Q8GZN1-F1-model_v4" }, { "swissprot_id": "A2AQ25", "sequence": "MEESEGQKCEPNLPPSGDSRQMPQQGRSNLHVTSQEDAACRRPRERLSNGNARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIMGHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTRASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMKMLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRMQREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIPGNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEPGTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSSSKEASSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPPSQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKVKETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPLHCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTASPPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPNSEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQTRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPNSHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKVTAGALRPSGPPKWERVMVDSISDTSRTSECRADTFTEENATPNKSLFRDSRNYSQKNVPKVSFSSSGLNSLEGEINKGPNVSGLQCAIPDLENQKLNFGKTKEIGQQGQENADKSHIPLPTRSAEFSIHDVKTQDQDVPVTGYGQVVLRSKVGRHANMNMNEDGESTPSSPSEEHTATDNIAFMITKTAVQVLSSGEVHDIVSQKGQDVQTVNIDGRKETASQHEGTEGEEPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMLTEEKIEEEEEDENEDSGVRTSSQMSCEQVDSRSDRMGQKAETQSQPHVLSAELLTPGVQGVRKAEQRKLSSADSPDSGNKCGMVDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEITRSQPEDALKTMARRQEQLSPEGTLPASRTDEIRKSTYRTLDSLEQTIKQLENTISEMSPRALVDTSCSSNRDCGASLPHMAQEVSPRSLLVLDEVPPAPEPPTSISPASRKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGDCKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRSAHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPTSLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS", "function": "Required for normal development of intervertebral disks.", "AFDB_id": "AF-A2AQ25-F1-model_v4" }, { "swissprot_id": "Q8L709", "sequence": "MNSTTTKNVCGDKWYLNLDRPEEALKILVFIAIFVVRTLLHYLMKPLGQPYLTTDFAIGLILGNIPRFRGAFSGPYSITLNNIIEFGMICHMFVMGLEMNPSVLLRPPTKDAFIAYTSMITTFVLAFVTTPFLHYTKTSPYIFSLALSLMASSTGSPILTRVIANLKIRKSDLGKLASAAGVHTDMISTLLYCFGFIFFPTEKPLARPLHRFFRALLMFCLFLAQVTFTSIVSPIFLNWVNNENPEGKPLKGSHLVMSLAFVVLICSFPTWPPESMYNPILSAFTAGLFLPNKGRMSKWIINKINYLLSTVFYPIFFFWVGFIIHMRNFDITDKMAWVRFFSLLGTVIAGKVTGTVLCGLLLGYHVPETASLGLLLTTKGHFHVYLAALAIRTNRVKSTTGALIIFIIVFTVVYSPFVVMDIIKRARKRVPVHIMALQWLDPTTELRILIGLHGPHNIGSTLNVMEICHGGREPGSIFYATDMVELTDEIAATLKKGGGAGQSNDSVTVTDRSVTEMRESITAAVNGYGELRNGQGVTVRRMLALSTFVTMAHDVCGLADELMVSIIILPFHKRLNPDGTLDAGHAGFRHVNRKILKNAPCSVGILVDRSFGQTEEAWRPGASMGIAIIFIGGRDDREALAFAAQVARHPAVKLKVIRFLEDKSSQNAQKRSSILNRASVVDQEEEMKLDDECFAEFYERYIAGGGRVSYMEKHLTNSSETFTALKSLDGEYGLVIVGRGGGRASSGLTTGLNDWQQCPELGPIGDVLSGSDFSHNTSMLIIQQQRTRGQLEGLHDDFTIL", "function": "May operate as a cation/H(+) antiporter.", "AFDB_id": "AF-Q8L709-F1-model_v4" }, { "swissprot_id": "O81900", "sequence": "MGGGSRFQEPVRMSRRKQVTKEKEEDENFKSPNLEAERRRREKLHCRLMALRSHVPIVTNMTKASIVEDAITYIGELQNNVKNLLETFHEMEEAPPEIDEEQTDPMIKPEVETSDLNEEMKKLGIEENVQLCKIGERKFWLKIITEKRDGIFTKFMEVMRFLGFEIIDISLTTSNGAILISASVQTQELCDVEQTKDFLLEVMRSNP", "function": "Transcription factor. Involved in the control of tapetum development. Required for male fertility and pollen differentiation, especially during callose deposition.", "AFDB_id": "AF-O81900-F1-model_v4" }, { "swissprot_id": "P56406", "sequence": "TVTVTYDPSNAPSFQQEIANAAQIWNSSVRNVQLRAGGNADFSYYEGNDSRGSYAQTDGHGRGYIFLDYQQNQQYDSTRVTAHETGHVLGLPDHYQGPCSELMSGGGPGPSCTNPYPNAQERSRVNALWANG", "function": "Specifically hydrolyzes the peptide bond at the imino side of aromatic residues.", "AFDB_id": "AF-P56406-F1-model_v4" }, { "swissprot_id": "O75410", "sequence": "MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD", "function": "Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.", "AFDB_id": "AF-O75410-F1-model_v4" }, { "swissprot_id": "P38779", "sequence": "MAKKSNSKKSTPVSTPSKEKKKVIEKKSSTAIPRERVIKAVNELIKFTSKPQDENNEEGNNGKKNLLEDDEEELKKDLQLIVVNNKSFTGTSKSFKLKLLNVKHSFYKPWKEASATAVKDFKVLLILKDSDIKKVSEDDLFDQLDSEGIKVDEIICGKDLKTVYKAYEARNAFISQFSLILADDSIVTSLPKLMGGKAYNKVETTPISIRTHANKEFSLTTLTNNIKKVYMNQLPVKLPRGTTLNVHLGNLEWLRPEEFVDNVELISEQLIKAYQIRSIFIKTNRSPVLPLYYNQDVLDELEAKKDKIEETHEDDMVTIDGVQVHLSTFNKGLMEIANPSELGSIFSKQINNAKKRSSSELEKESSESEAVKKAKS", "function": "An adapter protein that specifically links the 26S proteasome to its substrate CDC4 which is one of the substrate recognition subunits of the SCF E3 ubiquitin ligase complex. Required for turnover of cell cycle regulatory proteins CDC4 and GRR1. Required for synthesis and nuclear export of 60S ribosomal subunits. Required for vegetative growth.", "AFDB_id": "AF-P38779-F1-model_v4" }, { "swissprot_id": "Q56303", "sequence": "MKGWWGKILRVDLTNNKVWVQEYSPEVAKNFIGGRGLAAWILWNEAKNVDPLGPKNKLVFATGPFNGLPTPSGGKMVIAAKSPLTGGYGDGNLGTMATVHLRKAGYDALVVEGKAKKPVYIYIEDDNVSILSAEGLWGKTTFETERELKEIHGKNVGILSIGPGGENLVKYAVVISQEGRAAGRPGMGAVMGSKKLKAVVIKGTKEIPVADKEKLKELSQEAYDAILNSPGYPFWHRQGTMAAVEWTNENSALPTRNFSDGSFEFARSIDGYTMEGMKVKQRGCPYCNMPCGNVVLDAEGQESELDYENVALLGSNLGIGKLNEVSVLNRIADEMGLDTISLGVAISYVMEAKEKGIIKDDDAPEFGDFKKAKQLALDIAYRRGELGNLAAEGVKVMSEKLGAKDFAMHVKGLEVSGYNCYIYPAMALAYGTSSIGAHHKEAWVIAWEIGTAPIEGEKAQKVEYKITYDPEKAAKVIELQRLRGGLFEMLTACRLPWVEVGLSLDYYPKLLEAITGVKYTWDDLYKAADRVYALMRAYWVREFNGNWSREMDYPPERWFKEGLKSGPYKGQHLEKDKYDALLSEYYKLRGWDERGIPKKETLKELNLEFVIPELEKVTKLE", "function": "Catalyzes the oxidation of C1-C3 aldehydes. Involved in peptides fermentation.", "AFDB_id": "AF-Q56303-F1-model_v4" }, { "swissprot_id": "P08750", "sequence": "MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAIMIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEISQDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKELGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETSSIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERNGMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGKEKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKDYGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF", "function": "Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.", "AFDB_id": "AF-P08750-F1-model_v4" }, { "swissprot_id": "Q07897", "sequence": "MSNPDDLDDGLAYDFDAEHEVIFDAKDGSPPTKKVQKRSIEQDDDDVDDIDGKKEERNSEDDSNRPISKRQKKLQKKSKLIEKKKEESQYIVSQRKALPASSPEKIIEYLTTLIREKNPDLSVLELEELYFKRNDFLSTEKFDAERRLSNFPAFIQKFSVAPKKIVFSMSNIRVADVYRSLNGGKNCVKLFSKSKLKDDIATVERLLTDSSKKSNKNKDSLYFIATPTRMQKIIEATDLLFQGKEKLDIILDASYLDPKDNTILSFENAAVLCQVLKTFLNKKSSVKILLY", "function": "May play a role in the regulation of DNA replication and cell cycle control.", "AFDB_id": "AF-Q07897-F1-model_v4" }, { "swissprot_id": "A7HJZ9", "sequence": "MTSFSKSDTCVIFGGSFNPPHIGHTVILSYALDYFNADFYIIPTKTPPHKVVDIDFDKRFEWVMKSFKCFDTYKKNQIFLWDLEKHIFGVNYAIKNVEYFRKYYSNTIILVGEDALGNIEKWYKYEELLNITTFAIYPRTRDGSLYKRGQQILGNLYSNVIELRDFPLIEISSSDIRKRIVEGKSIIGFVDGEILEDVTNTYLMHHKSHGGNWNE", "function": "Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).", "AFDB_id": "AF-A7HJZ9-F1-model_v4" }, { "swissprot_id": "B0CN28", "sequence": "MTAPADTVHPAGQPDYVAQVATVPFRLGRPEELPGTLDELRAAVSARAGEAVRGLNRPGARTDLAALLAATERTRAALAPVGAGPVGDDPSESEANRDNDLAFGIVRTRGPVAELLVDAALAALAGILEVAVDRGSDLEDAAWQRFIGGFDALLGWLADPHSAPRPATVPGAGPAGPPVHQDALRRWVRGHHVFMVLAQGCALATACLRDSAARGDLPGAEASAAAAEALMRGCQGALLYAGDANREQYNEQIRPTLMPPVAPPKMSGLHWRDHEVLIKELAGSRDAWEWLSAQGSERPATFRAALAETYDSHIGVCGHFVGDQSPSLLAAQGSTRSAVGVIGQFRKIRLSALPEQPATQQGEPS", "function": "Heme-containing peroxygenase that mediates the hydroxylation of 3-methyl-L-tyrosine (3-Me-Tyr) into 3-hydroxy-5-methyl-L-tyrosine (3-OH-5-Me-Tyr) in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family. Involved in biosynthesis of 3-hydroxy-5-methyl-O-methyltyrosine (3-OH-5-Me-OMe-Tyr), a core structure of saframycin A.", "AFDB_id": "AF-B0CN28-F1-model_v4" }, { "swissprot_id": "Q7NBA6", "sequence": "MFKIREKTNADHKVKYIVDVNEKNWNEAYQKKLNAAVKNVKIQGFRKGHVPYQEAIKHIDQIGLFDRAVNQLVQPIYLELVKQEKIKDSETVLEENPEVSVVEIDDKKLALSYSFETIPEVKVGDYLKINGFLSETPVKDEDVQTELVRIFKSAGKLVDKKEGATLEKGDIAFLDFSGEIDNKAFEGGKAKNYELEIGSNSFIPGFEDQMVGMKVGEKRDLNLTFPKDYHEKTYAGKPVLFKVKLNSIKEVQLPEMTVEKLNELMKTQYKNLDEAKEDIKKRMDRNQQEHANQMNTMLLTQFANEDCQFSHIPKSLLDREVNLLYQQFANQMQQIKMSVEDALKIQNQTKEQLYQRLTEQATRAIKLVLVLEEIGDLEKISVSEAEINQEIEERIKEISNNQELPKEQYDAIKNYFVTQKELIESMLTNKKVVDLIIKKNLAR", "function": "Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.", "AFDB_id": "AF-Q7NBA6-F1-model_v4" }, { "swissprot_id": "Q16950", "sequence": "MKSLKSSTHDVPHPEHVVWAPPAYDEQHHLFFSHGTVLIGIVGSLIITVAVVGNVLVCLAIFTEPILSHSKSNFFIVSLAVADLLLALLVMTFALVNDMYGYWLFGETFCFIWMSADVMCETASIFSICVISYDRLKQVQKPLHYEEFMTTTRALLIIACLWICSFVLSFVPIFLEWHELSVEEIKAIFKDNKTEKEKALEAHNFSSALNQTLGDNQKSNAKHVCLFDVHFTYSVIYSFICFYVPCTLMLTNYLRLFLIAQTHQVRIRSLQMTNPPQLRGQGASSYRNQGTQGSKAARTLTIITGTFLACWLPFFIINPIAAADEHLIPLECFMVTIWLGYFNSSVNPIIYGTSNSKFRAAFKRLLRCRSVKSVVGSISPVSPAYRAFSWIRPSRLDLSSSEHPSDACDTGRGKNSKGGDCATADPTKPDVSVSEEIIYAGTKVFDSDTAFSS", "function": "This is one of the several different receptors for 5-hydroxytryptamine (serotonin). 5-HT plays important roles in various behavioral and physiological processes in aplysia. These include feeding, locomotion, circadian rhythm, learning and memory, synaptic plasticity, and synaptic growth. This receptor is mediated by G proteins that stimulate phospholipase C.", "AFDB_id": "AF-Q16950-F1-model_v4" }, { "swissprot_id": "Q3UM45", "sequence": "MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHGGGGIVANLSEQSLKDGVDRGAEDPEEEHELAVDMETINLDRDAEDVDLTHYRIGKIEGLEVLKKVKSLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEVLDISFNMLRNIEGIDKLTQLKKLFLVNNKINKIENISNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSVQSNRLAKIEGLQSLVNLRELYLSNNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATYVRF", "function": "Regulatory subunit of protein phosphatase 1.", "AFDB_id": "AF-Q3UM45-F1-model_v4" }, { "swissprot_id": "O83552", "sequence": "MVTDGASPRSGVSLIIGRPSSGKSTFLNAVCGYKVSIVSPIPQTTRNTVRGIVNIESDQIVFMDTPGYHRSDRKFNLRLQSLVHSNVKDADVLLYLVDATRQFGEEEAAICALLAPYQKTRVLLAFNKVDVLHNSTSCDEHAFLHRQGSVLRAGSLGRALHAALPHLPADRVFTISALHQVGLDALMRTLRDLLPEAAPLYPQDCYTDQTIAFRVTELIREQAIARCRDELPHALYAGVEDMELRRGKRELWCRAFLAVERESQKAVLVGKKGAVIRAIRLDAIRALRTLLPYHISLDIRVKVDRSWRQRDHTLSSLLY", "function": "An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.", "AFDB_id": "AF-O83552-F1-model_v4" }, { "swissprot_id": "Q2P856", "sequence": "MPFLELTLSCSEVTLPRFQNALDDVGAMAVTMLDANADTSNERALLEPGVGEMPLWDRLTMTALFDGGSDALVVLAALEAFDPGLDWSQVGFRMVEDSDWIRAWIDLFKSMQFGARTFIVPWNQDVPEAANAPDAAVVRLDPGLAFGSGTHQTTALCLRWLDSLAVSGELQGRSVLDFGCGSGILAIAALKLGASHAVGVDYDPQALLATADNAHRNALEAQLAVYMPQDEPVQTYQVVVANILASALSTLADTLAARVVPGGRIALSGILHGQEDELLERYAPWFEQLRCERDDEWMRIEGVRRAASGTQNG", "function": "Methylates ribosomal protein L11.", "AFDB_id": "AF-Q2P856-F1-model_v4" }, { "swissprot_id": "P07144", "sequence": "MAVPAFSDIAKSANDLLNKDFYHLAAGTIEVKSNTPNNVAFKVTGKSTHDKVTSGALEGKFTDKPNGLTVTQTWNTANALETKVEMADNLAKGLKAEGIFSFLPATNARGAKFNLHFKQSNFHGRAFFDLLKGPTANIDAIVGHEGFLAGASAGYDVQKAAITGYSAAVGYHAPTYSAAITATDNLSVFSASYYHKVNSQVEAGSKATWNSKTGNTVGLEVATKYRIDPVSFVKGKINDRGVAAIAYNVLLREGVTLGVGASFDTQKLDQATHKVGTSFTFES", "function": "Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.", "AFDB_id": "AF-P07144-F1-model_v4" }, { "swissprot_id": "P54716", "sequence": "MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDKERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIPLKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRRLRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLMPKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMVKKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYNTGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVEKLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS", "function": "Hydrolyzes maltose-6'-phosphate and trehalose-6'-phosphate. Is involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent maltose phosphotransferase system (PEP-PTS). Is also able to significantly catalyze the hydrolysis of both 6-phospho-alpha- and 6-phospho-beta-glucosides containing activated leaving groups such as p-nitrophenol and does so with retention and inversion, respectively, of the substrate anomeric configuration.", "AFDB_id": "AF-P54716-F1-model_v4" }, { "swissprot_id": "F3Y5P4", "sequence": "MKEKHENWSHPLAFWLCDCAAIIPNPATQNFAKNDFLDGLLMLNLMKFINPHFSENEKNGQSLYEELLNQISQFYEKNLDQVIVCKMPEISILESSGEIDEITFEELKKLLLLLLGCAIQSDHKKVFVDRITGFDQTIQAELAACIQKLTESDEIVQNLEDFERRKMKETDEVGGGGGSIEDVDSDDMESSTTSSSNGEIAIKQQDQSFLMSRSTSPTSELRHQTLQIANLQHEMRQMRTQAENRDEECQKLELDNEEKAQKIKILENERLKLVDFKKKWKSVNDDLQEANCKIEKLQNLVGIEKKYREARDGKELYKSKYDIVVKKNLEMEETITTLEKNLKTLQMEMKEKFGVEDNLQRMRNTIDDLEAEISKKNLEIEDFLDEKHRMDREIKELKEIVHQMEVPSTTTTPRIMDSLADQLENAKQDEFEMMKAEIRKLRAQTEGATPETTIIQCNQDLDTLRSQLSTEQHQTAQLHLEIQKMQVEKEQIDGNMERIGIELEEMSAQVENLNLERDEAVKQLLEARRKFGEFQMGQSRDLEEKWSKEVEKSNKISKKCEILEEKLQESDFLLAKSRDEAKKLQFELDEALEETSHVTRSLSSEKNTLKAKLLELQDQVEAQTLELLNQKNCGKRLEDRDQMISNLHNLKNELENDLKTCQTQLELESKKLQRLREDLVLEKSRRADLIGRIHSLCTTLSLNGANFEKINNDDELIDNIDDIMMNALVAVKRERDDLRIQGNQQIQELHDLKRDIEKLRRSESESLNESDDRVRELTRENMHTKEQVFMLQEKLRELNLELSTKNDEIDMVKASIEELNRNSTASCTSNAEIARLQVSIRNSQIQEDLVKQENTKLRDELQEMQKMSKKRSQNLDELENMHKTLLVDHSRLQQLHNLLTRDYDEAKKESMELRQKVQNIPRQQAVFMNANIRELEAKLSEEISRREQLEKEHKMCRIHCENLRRDITELVQTRDELSLELRRAHDTCHNKNNQIDELKKQLNQKISEVNKLSSKIEALSQLNRTYNEENRNLSRQLEILLTQNKELLQRALHDKDQYHLEMKDFQDQLSALRRHKEKLEDKIMDQYRTMENKKSTPERKQPLVKRAAKALINRRRATSNGGSTTEDSSVYSADERSSPPLAGTNEDVDHLPPTCSSSDDHDVISPDFSAKNPLLRSRNDFMGGSVRSPRRYGNDHDGHIYTSPFLPPRVPIRNSPMTSSLRSRPPPPPYNRSPAHKIEQNSSFFEPIAHSTPNSSILEERRVVGEGEKRELVRDKEERIDKTLSYYENVNLPQNPPDLPENSDLKPNESTIWHEYGCV", "function": "Scaffolding protein that plays a role in ciliogenesis, cilium positioning and dendrite anchoring in sensory amphid neurons including AWB, AWA, AWC, ADL and ASI and the phasmid neurons PHA and PHB. Its role in cilium positioning may be through regulation of the localization of cell adhesion proteins such as the apical junction protein ajm-1, and the ciliary scaffolding protein Rootletin/che-10.", "AFDB_id": "AF-F3Y5P4-F1-model_v4" }, { "swissprot_id": "Q54LB3", "sequence": "MTSTANNNTSFYCNNNNSNNNININCCSNTGHNGNNTTETTLTTVNEERCAPTPTPTSTPPHGSALNIQNSNNGCNNIIGSSSNTLSTPSVQATPPTPPPSSSSLLVQPMIVTPSPVVATTSSLITNDDNLNSSTNYLMLPHQAQSSAMTIVQPPPPSTPLSSSSTVVPASTPPPSVMTPITTIQTTATPPSLQPTIHHQTALSFLGYTYNEQYQQNICQLYHQLNANGNGNGNGNGNHNNNNNNYNYNNNSFYQHQQHQHGLYYNQFPIPMNSSVPIIPTQQYIGTKQPQSQSQSQQLQPQPQPQPQLQPQLQSQPQSQQLKRKEASYHNNNNNNNNNNNNNNNNNNNNNNPYNRPTKKIMVSQGLPPISSSPSFQNLNNKYFDFNQPITRNNYNQVNYNNNNNNNNNNNNNYNNISNNNPCNNNNNNKPNNNPNNNNSNSNKTYINKQHRDYGYENNNNNNNKTFQQTSQQQQQQQQQIYKKQNCNNYIDESGDDESGEEYQNYQPYQQYQNFKQNNKDNNNNDDDDDDDDDEEEEEEEEDDNDNCNGNDSYDEENNNNNNNNNNNNQFKNESIIIGDNYYEIINDRIKSIKQKLHFLEKNSKFQWIREKSFNFINEFTGESVVNEELGIRGSKDFSYLKYKTLNPSLDNYITQERIELKNPLIKANIEKLKKDFNFEITKINTTKSESLEIMKSIQQLSTTVRSPLLDRSDLKAQRNHIHGFFTLIIAHQKCLSFDFIYQMRPQSMDHQHGFSNTFTDDFTNGGGCSISDKKNRRTLNDQYKSFISDYFKNHSDHPYPNEDEKIIISALIDLSKYQRNNWFSNKRSREKNQRIVNLKKQIGFH", "function": "Putative transcription factor.", "AFDB_id": "AF-Q54LB3-F1-model_v4" }, { "swissprot_id": "O94527", "sequence": "MSGISLSLRQLDYRDWFQRKISRDIYGNSTWLTGIDLQKELTGHTGCVNTLDWSADGEFLLSGSDDTRLIVWDVFNEYKPRHLISTGHVQNIFSAKFVPYSNNRQILSASGDKLIKLFDLDSSKEGGMDHGMETQTRCWSCALDSVKNIVPCDNGHTFLVCSEDGTARQYDIREPHVCNQDLDCPSILVNYNPYRINLYTITMSPSNPYYFAIGGTHPYAFLYDRRMVKKSFRDDWTMNTSPEKDCRCVRKFSPDGSCNSQGILDRYITCCQFSAANPNELLVSWNSDYVYLFHVHEDKSYTPTFNKIEDSNKKPSKPSLLQTQPLKRKNYSPWYKNNFGASTPASRVSRNPYTAAQPRKHTFYQMYENIEKFFTTENGGLYESIVSGRLSHFSRSIQYVKDAIYFLENYNYIPDSNGLNHSIRVSALRYWRACVSILALMDDTVSLEPNTIIQAGWGWLYDFMNWVTRYLLGISDHWALQMSPPTNVARQNFVLCDPDEPSRVLFSNPSEMIRAFARIDTNDLSSVRRFFWIHKVLRGCLLLISSDIYWEQFQPWDSSTSDVTSSQRLDDENGFLTLLEPPVNYENEVESSSGENIVSMYTGHSDLNDDDDDYQDEESYSYASDDDDESDEDSDEGPTLLSLRMKKRKAVEPNVPVNTHVKSYYGHCNVESIKNVNFYGQNDEYVMSGSDDGRFFIWDKLNASILAIIHGDSEAVNVIEGHPRCPTLAVSGIDSTVKIFNTENTPPSGCSRNHTSNSYKIIATNEMNRQQGSRDSYITSRMLSHLAYRAHLDDGFGHEVLDTDACSIM", "function": "Ligand-dependent coactivator of nuclear receptors that may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.", "AFDB_id": "AF-O94527-F1-model_v4" }, { "swissprot_id": "Q27355", "sequence": "MILHGFHLSTSSHCLPFIFRHLFIFHSITALCDHVISNYCNSLKLSNNKFNQMLSKFVVVEVSNSNNTMTLVEYLVTHGFDKFAVVTDLVDHPSFKYKDGSSSPESPSTTASTAAQHTPPRTAVSTPTSINTPVPPHQNKQRHSIDKIAANLSTKKVSPSSIEKQLQRTSHNPLHQLSTPHALSQLQKLLEEQHKINQMNIQKKEQERQQAEIQRILLQQANAAQINHSFGLERLTPEYDDNHHSETISKASSEDLKTEPDSTDFGLGTSDDQVRASMLHLLHPVFAPAFGMLDAENIFGAASKPTTPASKRRNTDSNGAPSKKHRWLPVNELEESRSSRGKNCGRVHCKATYKCALCGKPTTLNSTGSRWNLLRHVIMIHSDCKPYKCWDCDFTGIKSNVISHARQCRHNAEDAHDITTDEMRAEWNLRLHECFPDYVRAKERGWQPEEVTVKKEEVEESPTLVKQELTLVKQEPTFAEQLEPMAQPLV", "function": "Probable transcription factor. Required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage.", "AFDB_id": "AF-Q27355-F1-model_v4" }, { "swissprot_id": "P13466", "sequence": "MAAAPSGKTWIDVQKKTFTGWANNYLKERILKIEDLATSLEDGVLLINLLEIISSKKILKYNKAPKIRMQKIENNNMAVNFIKSEGLKLVGIGAEDIVDSQLKLILGLIWTLILRYQIQMSESDNSPKAALLEWVRKQVAPYKVVVNNFTDSWCDGRVLSALTDSLKPGVREMSTLTGDAVQDIDRSMDIALEEYEIPKIMDANDMNSLPDELSVITYVSYFRDYALNKEKRDADALAALEKKRRETSDASKVEVYGPGVEGGFVNKSADFHIKAVNYYGEPLANGGEGFTVSVVGADGVEVPCKLVDNKNGIYDASYTATVPQDYTVVVQLDDVHCKDSPYNVKIDGSDAQHSNAYGPGLEGGKVGVPAAFKIQGRNKDGETVTQGGDDFTVKVQSPEGPVDAQIKDNGDGSYDVEYKPTKGGDHTVEVFLRGEPLAQGPTEVKILNSDSQNSYCDGPGFEKAQAKRPTEFTIHSVGADNKPCAAGGDPFQVSISGPHPVNVGITDNDDGTYTVAYTPEQPGDYEIQVTLNDEAIKDIPKSIHIKPAADPEKSYAEGPGLDGGECFQPSKFKIHAVDPDGVHRTDGGDGFVVTIEGPAPVDPVMVDNGDGTYDVEFEPKEAGDYVINLTLDGDNVNGFPKTVTVKPAPSAEHSYAEGEGLVKVFDNAPAEFTIFAVDTKGVARTDGGDPFEVAINGPDGLVVDAKVTDNNDGTYGVVYDAPVEGNYNVNVTLRGNPIKNMPIDVKCIEGANGEDSSFGSFTFTVAAKNKKGEVKTYGGDKFEVSITGPAEEITLDAIDNQDGTYTAAYSLVGNGRFSTGVKLNGKHIEGSPFKQVLGNPGKKNPEVKSFTTTRTAN", "function": "F-actin cross-linking protein.", "AFDB_id": "AF-P13466-F1-model_v4" }, { "swissprot_id": "Q59X67", "sequence": "MSTYSIPYYNQMNGNYNNGMPQQTTAANQQAFPQQQQPTTTGNASQQQQQAAATAAAAAVQQPYNYMFYQQQGQPGQQTGQTAGQQQQQQQQQQQYDYNTYNRYQYPAATSQGNYYQQTIPNQLSQPQPQHYNGSNRNYTSAPSGAPIPSNSTSGPSQQPPLPGQQAVPIPPHVSTMQQPTPVQDTLNASSTSTVGQFQPPGIRPRVTTTMWEDEKTLCYQVDANNVSVVRRADNNMINGTKLLNVAQMTRGRRDGILKSEKVRHVVKIGSMHLKGVWIPFERALAMAQREQIVDMLYPLFVRDIKRVIQTGVTPNAAAATAAAAATATSASAPPPPPPPVAAATTTAATAISKSSSGNGNSISATSGGSNVSGASGAGSTTSPVNTKAATTAGTPQGNYYQTYNQQQYPQQYGQYNAPGKNQNTPASQPGSTTNDQYLQQQQQMYGYQSNYYQGGAANSSYYPNYYQQQQPNYASSYPYQQQQQKQQQQQPNQQQQSDQQQTSTPSGGAGTRSVHQSPQVQSLTQGSVHPSPQQHQANQSASTVAKEEK", "function": "Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequence (EGRbox) TATGCATA. Acts as a major regulator of cell wall dynamics and plays a role in interactions with extracellular matrices. Required for TOR1-dependent cellular aggregation and adhesin expression. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections. Contributes to virulence by regulating hyphal formation and the factors that enable C.albicans to invade and injure endothelial cells. Required for the formation of thick-walled big resting spores called chlamydospores, which survive in unfavorable conditions. Mediates the expression of virulence factors SAP4, SAP5and SAP6 during infection. Involved in drug resistance by regulating the expression of ERG3.", "AFDB_id": "AF-Q59X67-F1-model_v4" }, { "swissprot_id": "P07287", "sequence": "MSSSDEQPRPRRRNQDRQHPNQNRPVLGRTERDRNRRQFGQNFLRDRKTIARIAETAELRPDLPVLEAGPGEGLLTRELADRARQVTSYEIDPRLAKSLREKLSGHPNIEVVNADFLTAEPPPEPFAFVGAIPYGITSAIVDWCLEAPTIETATMVTQLEFARKRTGDYGRWSRLTVMTWPLFEWEFVEKVDRRLFKPVPKVDSAIMRLRRRAEPLLEGAALERYESMVELCFTGVGGNIQASLLRKYPRRRVEAALDHAGVGGGAVVAYVRPEQWLRLFERLDQKNEPRGGQPQRGRRTGGRDHGDRRTGGQDRGDRRTGGRDHRDRQASGHGDRRSSGRNRDDGRTGEREQGDQGGRRGPSGGGRTGGRPGRRGGPGQR", "function": "This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.", "AFDB_id": "AF-P07287-F1-model_v4" }, { "swissprot_id": "O43561", "sequence": "MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN", "function": "Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.", "AFDB_id": "AF-O43561-F1-model_v4" }, { "swissprot_id": "P17208", "sequence": "MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEALAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHHHQALEPGDLLDHISSPSLALMAGAGGAGAAGGGGGAHDGPGGGGGPGGGGGPGGGGPGGGGGGGGPGGGGGGPGGGLLGGSAHPHPHMHGLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY", "function": "Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells.", "AFDB_id": "AF-P17208-F1-model_v4" }, { "swissprot_id": "Q11S04", "sequence": "MDKNQIIGISLISVLMLGYFGFMSTQTPETPVTTPPAITQPVQSDTVLLKSAATDTALKAQNQREYGDFAAAMVGEAKEYKLENKDVVVTLSTKGGTIKSVLLKNYFTWDKKQLFLFKQENNQLSLILNTNKKPVDLYSLYYAGVESKAGDKQVVTFKTDAGNGKTIEHTYTLGAAGFTVDYNLKAAGFGGELPNLPLTLDWREQVERIEYDSEQARVKSTVNYMAAEDGFDYLSEASKDRETETLSNVYWVSLKQKFFNSGFYIREGGTIPSATVTAYPMYSTLPNAPVNSEKFIKALEAQVQLPLEAVISGKAAYAFYFGPNDFKICKAVPAENYQKNVNLGWPLVSWINRFVVIPVFDGLKGVFSSFGLIIVILVLLIKLVLLPLSYKSFVSMAKMKALKPELDELKAKHGDDQQAIQMEQMQVYKQFGINPLSGCIPVLLQMPILLAMFNFFPNAIDLRGESLWWATDLSSYDEFAKLPFTIPFYGSHVSMFTLLMTISTLAYTWVNNQVSTVTGPMKYMSYAMPVVFLFVLNSFPAGLSFYYFVSNLVTIAQQLIIRRFVDEGQLRLQLEAKRDKNLSGDTTGGAPKKNRFMARMEEAMKQREQEQQFKKNIKKK", "function": "Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.", "AFDB_id": "AF-Q11S04-F1-model_v4" }, { "swissprot_id": "Q9W349", "sequence": "MHLHLLAAEKTPPSPSPNPTPTPSASPSGHTGAAGESQLDLASQTESQLQLGLPLASGYGLGLGLGLGLGLGLGQELVADHSTTVAPVSVAGPGRLGRSINGSGGSHHHHHLHHHYSPYHHAHPYHPPHPHAPHHHHHHHPPYPYPPAGPHPPAMVTSSSTSPTGNGWSSSTGDFKGITAVATATGGGVGGATQGATASTGATAAEVLAVSSSASVGSSSPTGGASNGTAHSGHSGHTGGHSSSTASNNNNNGASNSNSNNNNAVHQDLLWMERLVQKRQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPTGGPHYRALGLGQRPYIDGFPSTKALHELESLRRSAKVAAVTTAAAAAATAASAANAVAAAAAAVAVTPTGGGGGVAAGGVAGGAGAGLVQQLSSNYSSPNSTINSDCQVYKPNAPHIQAAEMMGAGEWTNGSSSSAAAYYHSHAHHPHAHHAHAHLQHQMALPPPPPPPAAAPVSVGVGGNGATMGMGMGVGVGMGMNHYGGGYDSANSLEAGQYAAHLPAVLPEMHGHGFATDPYQTAGYGGGNTGGGSASKSELDYGGSYNQAWSNGYQNYQYGSCLATAQYGPQAAPPPQPPPPPPVVLCPQLYSTVNQNQIHLHLHSSEKLEQYLGTATSADHLTIGSLTGSSRSSIEIGQDQYHQQVHHAQQQQQQQQQQQQVHHPQQQQVESAGEVGGSGAGGVESAREEDVGDLSQVWRPY", "function": "Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory sensilla development.", "AFDB_id": "AF-Q9W349-F1-model_v4" }, { "swissprot_id": "P47056", "sequence": "MKVQMIERIFLIQLCLLTVVLASSRAVVEFESTGTKLVNSLRVLAAYSQSSVCVDEKISGIERQIEEVKDMYGNHSFILKGLNGILNNKVNMLTREIQMETVGNNTFETETGKLTKGLNRAVNISPFKYIKKFKTVSTKKFESLLNKYDLVAKKGGELTEEQKKKKEVLSRISRVVAATTIEAGLAQGVVDLCITVTTSLCLVSASIGGVGFLIWLTIIYQALT", "function": "Involved in spore wall assembly.", "AFDB_id": "AF-P47056-F1-model_v4" }, { "swissprot_id": "Q9MAU3", "sequence": "MSIVPKETVEVIAQSIGITNLLPEAALMLAPDVEYRVREIMQEAIKCMRHSKRTTLTASDVDGALNLRNVEPIYGFASGGPFRFRKAIGHRDLFYTDDREVDFKDVIEAPLPKAPLDTEIVCHWLAIEGVQPAIPENAPLEVIRAPAETKIHEQKDGPLIDVRLPVKHVLSRELQLYFQKIAELAMSKSNPPLYKEALVSLASDSGLHPLVPYFTNFIADEVSNGLNDFRLLFNLMHIVRSLLQNPHIHIEPYLHQLMPSVVTCLVSRKLGNRFADNHWELRDFAANLVSLICKRYGTVYITLQSRLTRTLVNALLDPKKALTQHYGAIQGLAALGHTVVRLLILSNLEPYLSLLEPELNAEKQKNQMKIYEAWRVYGALLRAAGLCIHGRLKIFPPLPSPSPSFLHKGKGKGKIISTDPHKRKLSVDSSENQSPQKRLITMDGPDGVHSQDQSGSAPMQVDNPVENDNPPQNSVQPSSSEQASDANESESRNGKVKESGRSRAITMKAILDQIWKDDLDSGRLLVKLHELYGDRILPFIPSTEMSVFL", "function": "TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Required for proper pollen function. May stabilize the interaction of TFIID with selected promoters. Not redundant with TAF6B.", "AFDB_id": "AF-Q9MAU3-F1-model_v4" }, { "swissprot_id": "Q66FE0", "sequence": "MSDSDAMTDPNAVSYSNAIVVLCTAPDEASAQNLAAQVLGEKLAACVTLLPGATSLYYWEGKLEQEYEVQLLFKSNTDHQQALLTYIKQHHPYQTPELLVLPVRDGDKDYLSWLNASLL", "function": "Involved in resistance toward heavy metals.", "AFDB_id": "AF-Q66FE0-F1-model_v4" }, { "swissprot_id": "Q8L9G7", "sequence": "MTVAAGIGYALVALGPSLSLFVSVISRKPFLILTVLSSTLLWLVSLIILSGLWRPFLPLKANVWWPYALLVITSVCFQEGLRFLFWKVYKRLEDVLDSFADRISRPRLFLTDKLQIALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVERCSKVPFFLISAIIALAFVTIHTFSMVIAFEGYAKGNKVDQIIVPVIHLTAGMLTLVNFASEGCVIGVPLLYLVASLTLVHCGKMVWQRLLESRNQSSASR", "function": "Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.", "AFDB_id": "AF-Q8L9G7-F1-model_v4" }, { "swissprot_id": "P75728", "sequence": "MTNQPTEIAIVGGGMVGGALALGLAQHGFAVTVIEHAEPAPFVADSQPDVRISAISAASVSLLKGLGVWDAVQAMRCHPYRRLETWEWETAHVVFDAAELKLPLLGYMVENTVLQQALWQALEAHPKVTLRVPGSLIALHRHDDLQELELKGGEVIRAKLVIGADGANSQVRQMAGIGVHAWQYAQSCMLISVQCENDPGDSTWQQFTPDGPRAFLPLFDNWASLVWYDSPARIRQLQNMNMAQLQAEIAKHFPSRLGYVTPLAAGAFPLTRRHALQYVQPGLALVGDAAHTIHPLAGQGVNLGYRDVDALIDVLVNARSYGEAWASYPVLKRYQMRRMADNFIMQSGMDLFYAGFSNNLPPLRFMRNLGLMAAERAGVLKRQALKYALGL", "function": "Catalyzes the hydroxylation of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.", "AFDB_id": "AF-P75728-F1-model_v4" }, { "swissprot_id": "E8MF11", "sequence": "MNDQLTEVYASIDALIDYALAHLDLDPRNADWTRNQIFALFRLDSYPGPKTTTSAASVSDVVQDIVGSRSQAPYGEKTPDPLLAAFRAAATTAGLFKPEEGPAYADTIMGILSANPADLDDRFLLVEHRDGGMAAMQWFYDYCVANNYVKRAQLDRNPRFDSHGLTVTINLAKPEFKNMKKAAAGNAVAGGYPKCTICHENEGFAGRDKRTLRTLPVTLGGESWFWQFSPYGYFDQHGICVNTDHTPMHVDRDTFGHLLDFVDRFPGYFLGCNAALPRIGGSVLAHDHYQGGGELLPMHKAATWAAFTLADYPDAVVEILDWPGTAVRVVSKSRQSIIDVSDIIREAWVGYDDAANGIASHDADGNRQSALSPSAIITERGYEMSLIFRNNAISDEYPEGIFHAHPEYWPVKQEPIGLIEAQGLFILPGRLVDQLGIVEEALAEGRDLPDEVSEFSLEWGELAETLAGNHDREAIRQAVHDELGSVCYRILGNTAVFKQKATTQTFLESLGFAAR", "function": "Transfers the UMP unit from UDP-glucose (UDP-Glc) to Gal1P. Can also transfer the UMP unit to GlcNAc1P and GalNAc1P. Involved in the general galactose metabolism, and also involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria.", "AFDB_id": "AF-E8MF11-F1-model_v4" }, { "swissprot_id": "Q0WRW8", "sequence": "MKLYSVSIIIFVLIALSTIVNAQQAATDSCNSTLPLNDLTFNTSLLQCTEAWTPQNFILRYARTAENTWSFILSAPDSSAFIGIGFSTNGQMIGSSAIVGWIPSDGGSGTVKPYLLGGKSPGEVNPDQGDLTIVNGSLKIESVSSRLYMRFQLTATLPRQSLLYAVGPAGFFPSSPDFRLREHRFVTTTTINYNTGSQSVVKVSPHSKLKKTHGLMNMFGWGILIIVGAIVARHMKQWDPTWFYAHIALQTTGFLLGLTGVICGLVLENRLKANNVSKHKGLGITILVMGVLQMLALLARPDKQSKYRKYWNWYHHNIGRLLIILAISNIFYGIHLAKAGTSWNGGYGFAVAVLALTAIGLEVRKFLKK", "function": "May act as a catecholamine-responsive trans-membrane electron transporter.", "AFDB_id": "AF-Q0WRW8-F1-model_v4" }, { "swissprot_id": "P0CV34", "sequence": "MVIPHIICLPMALHLWTCRFLSLGRPATNRRNCRRLRRRAVHRQATRPTRRIHHSAPQSFPQGLFNCAFVLLRRHALCRRLVGISTHVRAFKNCSKSDGPRRHKRTGQNSRVCPCGSWIYRIVSDRSGAFKCARRRVL", "function": "Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins.", "AFDB_id": "AF-P0CV34-F1-model_v4" }, { "swissprot_id": "Q5AFH3", "sequence": "MVAPLVSESQSSSIEETDEQQQQYQQLARRRTIQSDLVDIEAESISSALPEGFNYEKKTTATRFLDKTQKYYPVILNIVHGAIWGVLVRKGLMSLTTYSGSFLSGVIWANFAACVVMGLAIDGEVFWIRLLEEKDYPNKGAIPVYTGLTTGFCGTVSSFSSVILEAFNKAADTDIGVRHHYPNGAYGIMQFLAVILAQFGLSIMGFHMGKQFSAVVDNYLPLVTKRIYKVLELTSMILGVVLVVITCILIGVKKQGSWRSWTFSMLFAPFGALLRYYLSKFLNNKVSNFPLGTFTANFLGTLLLAVFTLLARGKLPGGKGHIVTNTIALHVLEGLDDGFCGGLTTVSTFVVELFGLKTLFSYRYGTISILVCFAGVVLILGSYNWSVGLD", "function": "Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.", "AFDB_id": "AF-Q5AFH3-F1-model_v4" }, { "swissprot_id": "Q9STG9", "sequence": "MAATSSISSSLSLNAKPNKLSNNNNNNKPHRFLRNPFLNPSSSSFSPLPASISSSSSSPSFPLRVSNPLTLLAADNDDYDEKPREECGVVGIYGDSEASRLCYLALHALQHRGQEGAGIVTVSKDKVLQTITGVGLVSEVFSESKLDQLPGDIAIGHVRYSTAGSSMLKNVQPFVAGYRFGSVGVAHNGNLVNYTKLRADLEENGSIFNTSSDTEVVLHLIAISKARPFFMRIVDACEKLQGAYSMVFVTEDKLVAVRDPHGFRPLVMGRRSNGAVVFASETCALDLIEATYEREVYPGEVLVVDKDGVKCQCLMPHPEPKQCIFEHIYFSLPNSIVFGRSVYESRHVFGEILATESPVDCDVVIAVPDSGVVAALGYAAKAGVAFQQGLIRSHYVGRTFIEPSQKIRDFGVKLKLSPVRGVLEGKRVVVVDDSIVRGTTSSKIVRLLREAGAKEVHMRIASPPIIASCYYGVDTPSSNELISNRMSVDEIRDYIGCDSLAFLSFETLKKHLGEDSRSFCYACFTGDYPVKPTEDKVKRGGDFIDDGLVGGIHNIEGGWVR", "function": "Catalyzes the first committed step of 'de novo purine biosynthesis from glutamine. Required for chloroplast biogenesis and cell division. Confers sensitivity to the phenyltriazole acetic acid compound [5-(4-chlorophenyl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-acetic acid (DAS734), a bleaching herbicide.", "AFDB_id": "AF-Q9STG9-F1-model_v4" }, { "swissprot_id": "Q658Y4", "sequence": "MNIDVEFHIRHNYPWNKLPANVRQSLGNSQREYEKQVVLYSIRNQLRYRNNLVKHVKKDERRYYEELLKYSRDHLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLMNQCRSSKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDSGPQLSGSLDYNVVHSLYNKGFIYLDVPISDDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDEHTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWKNVPSVNRLKSTLDPQKMLLSWDGGESRSPVQEASSATDTDTNSQEDPADTASVSSLSLSTGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVTMFEVGKLSDESLDSFLIELEKVQSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQPNYGFPLDLLRCESLLGLDPATCSRVLNKNYTLLVSMAPLTNEIRPVSSCTPQHIGPAIPEVSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHDPGVVPTSNVLTMLNDALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADRKLSDASDERGEPDLASGSDVNGSTESFEMVIEEATIDSATKQTSGATTEADWVPLELCFGIPLFSSELNRKVCRKIAAHGLCRKESLQNLLHSSRKLSLQVLNFVHSFQEGASILDIHTEPSFSSLLSQSSCADMGVPLPAKNLIFKDGVLSEWSGRSPSSLLIANLHLQ", "function": "As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1.", "AFDB_id": "AF-Q658Y4-F1-model_v4" }, { "swissprot_id": "Q9HAU5", "sequence": "MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKENKEVSSPDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLTDSNKENETDEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR", "function": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.", "AFDB_id": "AF-Q9HAU5-F1-model_v4" }, { "swissprot_id": "P07492", "sequence": "MRGRELPLVLLALVLCLAPRGRAVPLPAGGGTVLTKMYPRGNHWAVGHLMGKKSTGESSSVSERGSLKQQLREYIRWEEAARNLLGLIEAKENRNHQPPQPKALGNQQPSWDSEDSSNFKDVGSKGKVGRLSAPGSQREGRNPQLNQQ", "function": "Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.", "AFDB_id": "AF-P07492-F1-model_v4" }, { "swissprot_id": "Q9WZS2", "sequence": "MRYSLFKNYLPKEEVPEIRKELIKLALPAMGENVLQMLFGMADTAFLGHYSWKAMSGVGLSNQVFWVVQVVLIAASMGATVTIANAIGAGNRKAVRSLAWNSVFLAIFTGVILTALTPLSDVLINIFPNLEGEIESSAKEYLKVILSGSMGFSIMAVFSAMLRGAGDTRTPMIVTGLTNFLNIFLDYAMIFGKFGFPEMGVRGAAVATILSRFVGAGILTYVIFKREEFQLRKGLVPPKWSSQKEILRVGFPTAIENFVFSTGVLMFANILLIAGAEAYAGHRIGINVESLSFMPAFGISVAITTLVGRYNGMGNKEHVLGVIRQGWILSLLFQVTVGIIIFLFPEPLIRIFTSDPQIIEISKLPVKIIGLFQFFLAIDSTMNGALRGTGNTLPPMIITFISIWTARLPVAFVMVKYFQLGLLGAWIGMIADIIFRSTLKLLFFLSGKWEKRAVLTRERVKELG", "function": "Multidrug efflux pump.", "AFDB_id": "AF-Q9WZS2-F1-model_v4" }, { "swissprot_id": "Q52154", "sequence": "MSDETLVNDPVNPEPARPASAAMAPPIVASPAKRIQAFTGDPDFMTSLARGLAVIQAFQERKRHLTIAQISHRTEIPRAAVRRCLHTLIKLGYATSDGRTYSLLPKVLTLGHAYLSSTPLAISAQPYLDRISDQLHEAANMATLEGDDILYIARSATVERLISVDLSVGGRLPAYCTSMGRILLAAMDDTSLREYLGRADLKARTSRTLHDPESLFACIQQVRAQGWCVVDQELEQGLRSIAVPIYDASGQVLAALNVSTHVGRVTRSELEQRFLPILLAASRDLCHQLFG", "function": "Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds.", "AFDB_id": "AF-Q52154-F1-model_v4" }, { "swissprot_id": "Q9D2Q3", "sequence": "METAIEDAGLDRGPTLTSSWDAACGALTQSLFLTRTGPRAQDLDFEQLLEPPAPSQDPVSLKSSLSPRDENPCFIYLNCGPNGGEEILSVGVLSSARNMEVYLGEEYCGTSRGKTACTVLDDSEHEKILLYKKYLKLDSPTHACKIKLLSFGEKQCVLVSKVVVHLRPRSADPSPRSAALGSRIDLDNIQTIMESMGSRLSPGAQQLMSMIRFQQQNRLPIGDQLQSVLGSAGHKHLMALQSSPSPAVLDKASSTPFPFRTGLTPSAITENLKALIDKSAQPSGEGNTTNHDEGHLMPQNHSLESDLKNAVSSFLPKKASGSSSVPSSELLPFLQNLCSQVNHLRVGHNARWQENISKPREGMVGVPMEEQPVCSYLEKILSKNMELMEKKLMDHIDERIYQLQEHIDAKMALLVDLLRGPNSPPPGMPLRHYDSRERLSNGER", "function": "ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival.", "AFDB_id": "AF-Q9D2Q3-F1-model_v4" }, { "swissprot_id": "Q3IKY9", "sequence": "MPDTITNKLQNSTVQDVIATKLARAVFAGFEAMFATFLNITLGAQSRFEQRQYHEVQSAMRERLQVYERQVKSVSEAVKVIAYAELSCPQTWQLAKNIYGNMVKNHENEPIAHTFFNSTFGAIWDDKKIRTVHLFVLKAKYRTQPRPYDSLVKRISLQHGFNSAIKTLITNQVFRVPFSNLNQDVATLQATLTQGAKQQCRQVYELINLNDGYIEYAYSHFYRNKACYLIGRCIAKNGDNMPFAIAILNTPKGLKIDAVMMGADQLSLLFGFARTYFMVDTDQPARYVDYLSVLMPHKQRFELFNAIGFIKHAKTEFYRYKVDTTKNSPASFKYVAAPGTPGMVMLVFTIAGSDHVYKVIKDKFSAPKTATKAQVKEKYNFVKQADRVGRLVDTHEFRYLAFDLSRFSEQLLQQMKEHIGSSLIISGKALILKHVYVERKMTPLNLYINDCDSKALAQVMLDYGRAIKDLAGANIFPGDMLMKNFGVTRWGRVVFYDYDEICPLTDCNFREVPQTQNALEELSSDSYFDIEPNDIFPSQFKVFFSANELAFNAFNSHHSDLFNAQFWQTCQQQVQQGYLPDVYPYKQSWRFK", "function": "Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.", "AFDB_id": "AF-Q3IKY9-F1-model_v4" }, { "swissprot_id": "O43000", "sequence": "MALLNRLAKTFSPYYGLNKVEQKLLIKIDWFILSYCCVSYFINYLDRSSINNAYLSGMQEDLKMHGNELQDINVVFTCGYIIGQLPGSYALQRVPARLWFSVMNILWGLMTIFSFAVHSVRALMILRFFMAVAEASTFAGTHYILGAWYKESELCKRAGIFSASGLVGTMFAGYLQTAVHSSLNGKGGLSGWRWLFIIDGILTIPLSLYGLFLFPDVPETTKAPYFTEQEKELSFKRLPARPKKKPLTLKAIKDIVRSWRIYGLCILWIFSGETQAIAVNVLMGQWMKWSNKFSVAQINNYPTVITAVGVVSTLGASVISDKLAGNPRWPFGLFLCVITTVSATILLAWNVPDGAKFFAYFASGCTYAGQAVWFSWANDICRDNDQERGVVVFLMNMCQNIWHIWWAPIMYPNTDTPRFIKGLIGLLVVGGIVFVSSCIVSYMQIRDKRIKRSIQDAKDFDDVFTEHESLELKKIGKNDEESLNTTNAVKEISSPGLVITRQRISMPKETNAQD", "function": "Transports pantothenate into the cell.", "AFDB_id": "AF-O43000-F1-model_v4" }, { "swissprot_id": "P43896", "sequence": "MSLLRSLRLCLVARTGSCPLSALGPGPLLPSLQAGLPLLQSPQQWHTFHSGSWLSSASSKELLMKLRRKTGYSFINCKKALETCGGDLKQAESWLHKQAQKEGWSKAARLHGRKTKEGLIGLLQEGDTTVLVEVNCETDFVSRNLKFQQLVQQVALGTLLHCQNLKDQLSTYSKGFLNSSELSELPAGPEREGSLKDQLALAIGKLGENMILKRAAWVKVPAGFYVGSYVHGAMHSPSLHNLVLGKYGALVICETSELKANLADLGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYVQPHGVSVVDFVRFECGEGEDAADAE", "function": "Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.", "AFDB_id": "AF-P43896-F1-model_v4" }, { "swissprot_id": "Q06401", "sequence": "MAEQEYDLIVVGSGAGACWAPIRAQEQGLKTLVVEKTELFGGTSALSGGGIWIPLNYDQKTAGIKDDLETAFGYMKRCVRGMATDDRVLAYVETASKMAEYLRQIGIPYRAMAKYADYYPHIEGSRPGGRTMDPVDFNAARLRVTALETMRPGPPGNQLFGRMSISAFEAHSMLSRELKSRFTILGIMLKYFLDYPWRNKTRRDRRMTGGQALVAGLLTAANKARVEMWCNSPLKELVQDASGRVTGVIVERNGQRQQINARRGVLLGAGGFERNQEMRDQYLNKPTRLVDGNPCGRQYGDAHRAGQAWAHTGADGLVLGRAHHGCSQGAGLSRHFRGTLAAGVHGGQRQGAALPQRVRPVSGIPAAMLAENAKGNGGVPAWIVFDASFRAQNPMGPLMPGSAVPDSKVRKSWLNNVYWKGRRWKIWRADRRGRAGLQVSARRMTEYARAGKDLDFDRGGNVFDRYYGDPRLKNPNLGPIEKGPFYAMRLWPGEIGTKGGLLTDREGRVLDTQGRIIEGLYCVGNNSASVMAPAYAGAGSTLGPAMTFAFRAVADMVGKPLPLENPHLLGKTV", "function": "Dehydrogenates steroids by introducing a double bond in steroid ring A.", "AFDB_id": "AF-Q06401-F1-model_v4" }, { "swissprot_id": "Q03761", "sequence": "MSSNPENSGVNANNNTGTGNADAITGAQQNMVLQPRQLQEMAAKFRTLLTEARNVGETTPRGKELMFQAAKIKQVYDALTLNRRRQQAAQAYNNTSNSNSSNPASIPTENVPNSSQQQQQQQQQTRNNSNKFSNMIKQVLTPEENQEYEKLWQNFQVRHTSIKEKETYLKQNIDRLEQEINKQTDEGPKQQLQEKKIELLNDWKVLKIEYTKLFNNYQNSKKTFYVECARHNPALHKFLQESTQQQRVQQQRVQQQQQQQQQQQQQQQQQQQQQQQRQGQNQRKISSSNSTEIPSVTGPDALKSQQQQQNTITATNNPRGNVNTSQTEQSKAKVTNVNATASMLNNISSSKSAIFKQTEPAIPISENISTKTPAPVAYRSNRPTITGGSAMNASALNTPATTKLPPYEMDTQRVMSKRKLRELVKTVGIDEGDGETVIDGDVEELLLDLADDFVTNVTAFSCRLAKHRKSDNLEARDIQLHLERNWNIRIPGYSADEIRSTRKWNPSQNYNQKLQSITSDKVAAAKNNGNNVASLNTKK", "function": "Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.", "AFDB_id": "AF-Q03761-F1-model_v4" }, { "swissprot_id": "A4WL93", "sequence": "MSRQDVRQEIQRLIEEYQLVGELLTNLQAQHATVSELLEELTTALDGVRLLKGGAGERLVHIGAGLFVKGVFETKEVLTPLGAGYHAFLDLDNAERVLQERIEEYSRLKTSLEENIGKLAERAEQIRQVLERLGIR", "function": "Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.", "AFDB_id": "AF-A4WL93-F1-model_v4" }, { "swissprot_id": "B0R474", "sequence": "MALGTYVPTAIRTSLLRKAAVVIVTIMLVLVGVGVFTTQAVSTQVTEQRDTELLTSTEQEAEALEEWIGRQRSATQYLSQDNAIQSAPQADKSEVLSTRISGLTETAAALHYVNLSTDTIRASTDAAVEGDTYTSYSIPWRGEGLSFYGGGDVITSSVFNYRGTPVMAFASKQPGSDNAVFVFHSVETRGEAFSRNIDGSYTQVVDIEGTVQIAADESAISSAYGAGRDAPVIATGLTTNSGIETRDGLLVGHAKVEGTDWVLLKHAPTSNAYALEGDVQRNIVVLIVTAVAGLGALVLVIGRDALTALTDMSDRAEAIAAGDIDTAIEETTRIDEVGDLRRSFRDIQEYLQTVAGQADALAEQDFDADALDKSVPGRLGESLETMHWDLETAIADLEDAQETAEQSRKEAEQSREEAEALAAALESQAQDIRETVEHAADGDLTQRLETDTDHESMAAIATALNSLLEELEGTIHRIQRFSKDVAESSDHITTSAEEVKRASGQVSESVQEMSADARQQNGIVQDVSDEMTDLSATIEEIASSSDEVAAKSNDAVSVGQSGRARSQDAIEEMNAVDEQAKRTIAEMEALDDEMTEIGEIVTLIDDIAEQTSMLALNASIEAARAGEAGEGFAVVADEIKSLSKETTEATQEIESLIADVQDSTTDAVTDMQEMGDRLSEGKSTVTDTVETIDTIVERIEEANGGVQTINTATDEQATTTEEVVTMVDEVGSISDDTTARAEDAAAAAEEQTASLTEVTNRIQDLSDQSTDLYELLSDFTVREDHAVADGGAENTTGAFVRSASTDHSRDATHHDT", "function": "Potentially involved in chemo- or phototactic signal transduction.", "AFDB_id": "AF-B0R474-F1-model_v4" }, { "swissprot_id": "P49072", "sequence": "MISRVLVAALVALPALVTATPAPGKPKASSQCDVGEIHCCDTQQTPDHTSAAASGLLGVPINLGAFLGFDCTPISVLGVGGNNCAAQPVCCTGNQFTALINALDCSPVNVNL", "function": "Forms hydrophobic rodlet layers.", "AFDB_id": "AF-P49072-F1-model_v4" }, { "swissprot_id": "Q1AUF5", "sequence": "MTRRKLGRMKVRPPDPETAQRYLLRFTGRQLYHEAERLPGLSSPELFGDQRPLELDVGCGTGEYICHLARSDPEANFVGVDLHLKSLHKAIRRAEEANLQNIKFICADFRQMYPLLRPSALRAVYLHFPDPGIKPRYRKRRLFNERFLEEMHRAVVPGGRMSLVTDDEDYFRQMLELIERDGRWRRAHEEPYLTGFDPPVKSRFQKMWERRGRTIYRFELVRP", "function": "Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.", "AFDB_id": "AF-Q1AUF5-F1-model_v4" }, { "swissprot_id": "P70056", "sequence": "MRDPSSLYSGFPAGSQYESVEPPSLALLSSIDQEQLPVATGQSYNHSVQHWPQPWPPLSLYREGGTWSPDRGSMYGLSPGTHEGSCTHTHEGPKDSMAGDQTRSRKSKKKNYHRYNKPPYSYLAMIALVIQNSPEKRLKLSQILKEVSTLFPFFNGDYMGWKDSIRHNLSSSDCFKKILKDPGKPQAKGNFWTVDVSRIPLDAMKLQNTALTRGGSDYFVQDLAPYILHNYKYEHNAGAYGHQMPPSHARSLSLAEDSQQTNTGGKLNTSFMIDSLLHDLQEVDLPDASRNLENQRISPAVAMNNMWSSAPLLYTHSKPTRNARSPGLSTIHSTYSSSSSSISTISPVGFQKEQEKSGRQTQRVGHPIKRSREDDDCSTTSSDPDTGNYSPIEPPKKMPLLSLDLPTSYTKSVAPNVVAPPSVLPFFHFPRFTYYNYGPSPYMTPPYWGFPHPTNSGGDSPRGPQSPLDLDNMLRAMPPNKSVFDVLTSHPGDLVHPSFLSQCLGSSGSPYPSRQGLM", "function": "Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 1 (ARF1), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much lower affinity than fast3. Necessary for the first steps in mesoderm specification, directly inducing mesodermal genes. Acts with fast3 to control the convergent extension movements of gastrulation. Binds to the proximal element (PE) of the gsc gene and cooperates with gtf2ird1/wbscr11 and SMAD proteins to regulate gsc transcription.", "AFDB_id": "AF-P70056-F1-model_v4" }, { "swissprot_id": "O14169", "sequence": "MAFNYSIANTVDDAAQSIAENTSSLATFSKPPLVIAHRGYKAKYPENTILAFQQAVKAGADCVETDVRLTKDEVVCILHDRNLNRVFGVDVDVRDLDYELDNGHFRTIQEPHEPLPTYEQFLHELTKHPGVNLLVDIKPVNDLLIIPRMVDAMLRVNSDLDFWKDKVSFCLWSHRFIPACDRYAPSIPLYHIGFNFAYAERHFVMHPRVKGVSMAVALFLLPHSQDFVDLVHAQGKQVFAWTLNTPSSIYLALIRGCDGLLSDDPVMARALSQGPIVTKSWHYFHYSEWLHMIYGFLRAQFVFFLLRTFVL", "function": "Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C-type degradation mechanism.", "AFDB_id": "AF-O14169-F1-model_v4" }, { "swissprot_id": "Q7NAQ7", "sequence": "MFKSWSKRLKYAPTPLVGDEVLRAQGLKCVFDEKTPEEFWALNGIDFTFEKNKIYCIIGNSGSGKSTLVTHFNGLLTSKYGTLSIRDFKNNHDIVISPNTKKIKNFKRLRKIISMVFQFPEYQLFKDTIQKDIMFGPVALGVHKEEAAKLAKFYLNRMGLDSSYLDVSPFELSGGQKRRVAIAGILAIQSEIIIFDEPTAGLDPKGESEMVELILESKKENKTVIVITHQMEKVLEIADEVILLDKGKILTSGTPYQIFTNPEIMQTTSIALPHVVQVINDLSLRNPIFKKLYDYEPRTVKDLAKVINEVIKNYEKRN", "function": "ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.", "AFDB_id": "AF-Q7NAQ7-F1-model_v4" }, { "swissprot_id": "Q81SW4", "sequence": "MEKVDIFKDIAERTGGDIYFGVVGAVRTGKSTFIKKFMELVVIPNIENESDRQRAQDELPQSAAGRTIMTTEPKFVPNQAVSIEVDEGLEVNIRLVDCVGYTVPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGEIPRRDYIEAEERVVNELKEVGKPFIMIINTVQPYHPDTEQLRQSLSEEYDIPVIAMSVESLRETDVYNVLREALFEFPVLEVNVNLPSWVMVLNEGHWLRQSYQEAVQETVKDIKRLRDVDRVVWQFSQYEFIDRASLAGIDMGQGVAEIDLYAPDELYDQILKEVVGVEIRGKDHLLKLMLDLSHAKIEYDQVADALRMVKQTGYGVAAPALADMSLDEPEIIRHGSRFGVKLKAVAPSIHMIKVDVESTFEPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLSSIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL", "function": "ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Directs the assembly of the coat and exosporium to an area around the forespore.", "AFDB_id": "AF-Q81SW4-F1-model_v4" }, { "swissprot_id": "O22609", "sequence": "MATTTSCSLLLSSTLFLHSPPSSHLSFFNLSSSRSSPISLYPIRSKRYFRILSKLSLNDNNRDDDDDTLHFTPFSAVKPFFLLCTSVALSFSLFAASPAVESASAFVVSTPKKLQTDELATVRLFQENTPSVVYITNLAVRQDAFTLDVLEVPQGSGSGFVWDKQGHIVTNYHVIRGASDLRVTLADQTTFDAKVVGFDQDKDVAVLRIDAPKNKLRPIPVGVSADLLVGQKVFAIGNPFGLDHTLTTGVISGLRREISSAATGRPIQDVIQTDAAINPGNSGGPLLDSSGTLIGINTAIYSPSGASSGVGFSIPVDTVGGIVDQLVRFGKVTRPILGIKFAPDQSVEQLGVSGVLVLDAPPSGPAGKAGLQSTKRDGYGRLVLGDIITSVNGTKVSNGSDLYRILDQCKVGDEVTVEVLRGDHKEKISVTLEPKPDES", "function": "Serine protease that is required at high temperature. May be involved in the degradation of damaged proteins. In vivo, can degrade beta-casein.", "AFDB_id": "AF-O22609-F1-model_v4" }, { "swissprot_id": "Q2YIF7", "sequence": "MKRILLAEDDNDMRRFLVKALEKAGYHVTHFDNGASAYERLQEEPFSLLLTDIVMPEMDGIELARRATEIDPDLKIMFITGFAAVALNPDSDAPRDAKVLSKPFHLRDLVNEIEKMLIAA", "function": "Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. CpdR is a response regulator substrate of ChpT. Unphosphorylated CpdR controls steady-state levels of CtrA in the B.abortus cell, likely via CtrA destabilization and activation of its proteolysis.", "AFDB_id": "AF-Q2YIF7-F1-model_v4" }, { "swissprot_id": "Q97BJ3", "sequence": "MRLLDKDEKLGRYTLRIENLDDLWYLKNIIAPGDKISAVTFRRIEESSDMQRSREKERIPIRVTIEVEKIEFQDFENRLRILGKVTNGPEDTIGKYQSITVSEETELDVIKVWDDDSINMLKEATEQEHAAVYLAIALDDDEANVFIIHPYGIQQMGTIYSGRSGKYSESSYSETSYFSAIENAIKQFKYPIIVIGPGFAKNGLSAFLKERNYKVVAVSSSNRTDQGAIYEFISSEDGKKLISKEQISRDNEIVSAFLSSLRRGSGIYGSEEIRKYLEMGALSDLIITDKKFRSETGRELLSLARSVGTDIHIVSTSNDMGEIIEKFGGYAGILRYKVQQ", "function": "May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.", "AFDB_id": "AF-Q97BJ3-F1-model_v4" }, { "swissprot_id": "Q8CCK0", "sequence": "MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVGAPVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIASGGVLPRIHPELLAKKRGTKGKSETILSPPPEKRGRKAASGKKGGKKSKATKPRTSKKSKAKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHPTTAEIDLKEEIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAISAHFDDSSSSSLKNVYFLLFDSESIGIYVQEMAKLDTK", "function": "Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.", "AFDB_id": "AF-Q8CCK0-F1-model_v4" }, { "swissprot_id": "Q9Y806", "sequence": "MILNRRIQVILPTLLILSFIIWIFHSVMVDKDWRLFMPEIKSLPDREGQGRKPIEMMSTKHDNNTNNLMVNAYWKLIHTVVSNYPNRPTLDERDILRHYLFSSAITMPCGEYSVELQKILDVHPPQTSSRKAATTWACKVHNQLNEKMNQPKTSCDGFNERYVIGSPTYRESEAENVPERVQVINEDHDYSG", "function": "FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen.", "AFDB_id": "AF-Q9Y806-F1-model_v4" }, { "swissprot_id": "Q4WAZ4", "sequence": "MLGLPNELSGSQVPGATEYEPGWRRVFKVEDLPGLGDYHIDNQTAVPTSIVCVIALAAAMDISNGKQANSIELYDVTIGRPIHLGTSPVEIETMIAIEPGKDGADSIQAEFSLNKSAGHDENPVSVANGRLRMTFAGHELELLSSRQAKPCGLRPVSISPFYDSLREVGLGYSGPFRALTSAERRMDYACGVIAPTTGEASRTPALLHPAMLEACFQTLLLAFAAPRDGSLWTIFVPTQIGRLTIFPNSSVGINTPASVTIDTHLHEFTAGHKADLPMIKGDVSVYSSEAGQLRIRLEGLTMSPIAPSTEKQDKRLYLKRTWLPDILSGPVLERGKPVFCYELFGLSLAPKSILAATRLLSHRYAKLKILQVGTSSVHLVHSLCRELGSSMDSYTIACESDSSMEDMRRRLLSDALPIKYVVLDIGKSLTEGDEPAAGEPTDLGSFDLIILLKASADDSPILKRTRGLIKPGGFLLMTVAATEAIPWEARDMTRKAIHDTLQSVGFSGVDLLQRDPEGDSSFVILSQAVDHQIRFLRAPFDSTPPFPTRGTLLVIGGASHRAKRPIETIQNSLRRVWAGEIVLIRSLTDLQTRGLDHVEAVLSLTELDQSVLENLSRDTFDGLHRLLHQSKIVLWVTYSAGNLNPHQSGAIGLVRAVQAETPDKVLQLLDVDQIDGNDGLVAESFLRLIGGVKMKDGSSNSLWTVEPELSVQGGRLLIPRVLFDKKRNDRLNCLRRQLKATDSFEKQSALARPIDPCSLFSPNKTYVLAGLSGQMGQSITRWIVQSGGRHIVITSRNPDKDDLWTKELEQRGAHIEIMAADVTKKQEMINVRNQILSAMPPIGGVANGAMLQSNCFFSDLTYEALQDVLKPKVDGSLVLDEVFSSDDLDFFLLFSSISAVVGQPFQANYDAANNFMTGLVLQRRARNLPASVINLGPIIGLGFIQNIDSGGGSEAVIATLRSLDYMLVSERELHHILAEAILIGKSDETPEIITGLETVSDNPAPFWHKSLLFSHII", "function": "Stereoselective keto-reductase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2). The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520. The initial oxidation of beta-trans-bergamotene by the multifunctional cytochrome P450 monooxygenase af510 involves C-H hydroxylation at the bridgehead C5 position to yield 5R-hydroxyl-beta-trans-bergamotene. Subsequently, a four electron oxidation initiated at C-9 coupled to cleavage of the cyclobutane C5-C8 bond of the bicyclo[3.1.1] core yields the epoxyketone intermediate 5-keto-cordycol. An additional epoxidation reaction also catalyzed by af510 then furnishes the characteristic bisepoxide ketone 5-keto-demethoxyfumagillol. 5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene. The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin. Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin.", "AFDB_id": "AF-Q4WAZ4-F1-model_v4" }, { "swissprot_id": "Q8CH25", "sequence": "MAAAAGAVVASAASGPAEGKKITELRVIDLRSELKRRNLDINGVKTVLVSRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKQEADELSGDASVEDDSFVKDCELENQETHDQDGNEELKDLEEFGENEEEIVHSQELLSTEENKTTQEFVEAEAIEDREKEDIESQETEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEANATGKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDVQDAIAQSPEKEAKDYEMNPNHKDGKKEDSVKGEPVEKEARESAKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTGSAGGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCVAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSAGDKKNASDRSAKTQASIKKEEKRSSEKSEKKESKDTKKIEKDEKNDDGPSGQTSESLKKSEEKKRISSKSPGHMVILNQTKGDHCRPSRRGRYEKGHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLKQAVEFRRRKEIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRREAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTEARFGHGSDYRQQSRFLDFSHRERARFPDTASVQSSFERRERFVGQSEGKKPRPAARREEPSFERYPKNFSDSRRNEPPPPRNELRETDRREVRGERDERRTVILHDRPEVAHPRHPRETVPNPSRPTSWKSEANMSTEKRESRVERPERSGREVSGHTVRGAPPGNRSSASGYGTREGERGVIADRGSGTQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSTASPVNRIVQMSGNSLPRGSSSGFKPFKSGPPRRF", "function": "When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.", "AFDB_id": "AF-Q8CH25-F1-model_v4" }, { "swissprot_id": "P07921", "sequence": "MADHSSSSSSLQKKPINTIEHKDTLGNDRDHKEALNSDNDNTSGLKINGVPIEDAREEVLLPGYLSKQYYKLYGLCFITYLCATMQGYDGALMGSIYTEDAYLKYYHLDINSSSGTGLVFSIFNVGQICGAFFVPLMDWKGRKPAILIGCLGVVIGAIISSLTTTKSALIGGRWFVAFFATIANAAAPTYCAEVAPAHLRGKVAGLYNTLWSVGSIVAAFSTYGTNKNFPNSSKAFKIPLYLQMMFPGLVCIFGWLIPESPRWLVGVGREEEAREFIIKYHLNGDRTHPLLDMEMAEIIESFHGTDLSNPLEMLDVRSLFRTRSDRYRAMLVILMAWFGQFSGNNVCSYYLPTMLRNVGMKSVSLNVLMNGVYSIVTWISSICGAFFIDKIGRREGFLGSISGAALALTGLSICTARYEKTKKKSASNGALVFIYLFGGIFSFAFTPMQSMYSTEVSTNLTRSKAQLLNFVVSGVAQFVNQFATPKAMKNIKYWFYVFYVFFDIFEFIVIYFFFVETKGRSLEELEVVFEAPNPRKASVDQAFLAQVRATLVQRNDVRVANAQNLKEQEPLKSDADHVEKLSEAESV", "function": "LAC12 mediates the transport of lactose and it would appear that the permease works in part by a proton symport mechanism.", "AFDB_id": "AF-P07921-F1-model_v4" }, { "swissprot_id": "Q17RS7", "sequence": "MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKPHLRNLFFRISYLTQMDVKLVFVMEGEPPKLKADVISKRNQSRYGSSGKSWSQKTGRSHFKSVLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRWNETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHDRQLSEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFTLEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHYAMEDKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQKRIKPKENNLPEPDEVMSFQSHMTLKPTCEIFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTPCLNAQEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPAIQRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDEDSDGISPEEHLLSGITDLCLQDLPLKERIFTKLSYPQDNLQPDVNLKTLSILSVKESCIANSGSDCTSHLSKDLPGIPLQNESRDSKILKGDQLLQEDYKVNTSVPYSVSNTVVKTCNVRPPNTALDHSRKVDMQTTRKILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKLSSPKIHIKETEQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLRQRLKLRFQST", "function": "Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction. Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA. Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates.", "AFDB_id": "AF-Q17RS7-F1-model_v4" }, { "swissprot_id": "Q06AN9", "sequence": "MMENLLANCVQKNLNHFMFTNAIFLCELLLAQFPSEVNLQLLARCYLSNSQAYSAYYILKGSKTPQSRYLFAFSCFKLDLLGEAEAALLPCEDYAEEVPGGAAGHYLLGLIYRYSGRKNCSIQQFRMALSFDPLCWEAYGELCSLGAAEEASTVFGNVASQRLQKTCVEQRISFSEGATIDQITDSDKALKDTGLSQTEHIPGENQQDLKIMQQPGDIPPNTDRQLSTNGWDLNTPSPVLLQVMDALPPLLLKNMRRPAVEGSLMSVHGVRVRRRNFFSEELSAEAQEESGRRRSARIAARKKNPMSQSFGKDSHWLHLSPSESNYAPSLSSMIGKCRIQSSKEATTSGQSVSDIGSSVDDEEKSNPSESSPDRFSLISGISEVLSLLKILGDGHRHLHMYKCQEALLAYQKLSQKQYNTHWVLMQVGKAYFELQDYFNADSSFTLAHQKYPYALEGMDTYSTVLYHLKEEMRLGYLAQELISVDRLSPESWCAVGNCYSLRKDHDTALKMFQRAIQLNERFTYAHTLCGHEFAALEEFEDAERCYRKALGIDTRHYNAWYGLGMTYLRQEKFEFAQHQFQLALQINPRSSVIMCYYGIALHESKRNDEALMMMEKAVLTDAKNPLPKYYKAHILTSLGDYHKAQKVLEELKECAPQESSVHASLGKIYNQLKQYDKAVLHFGIALDLSPSPSDAVKIKAYMERLILPDELVTEENL", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication. Functionally redundant with CDC27B in the control of gametophyte development.", "AFDB_id": "AF-Q06AN9-F1-model_v4" }, { "swissprot_id": "P29007", "sequence": "MEGVLLFWKYRALFFLVLCSLVLCKVHLSQASPTSQQHNDAASLSKIYPRGSHWAVGHLMGKKSIEEYPYAYDEADRSSAAVFSEGDKPSDGYQQWKESLLNLLKMIEVNEYRNSKAMREASVYNKKFSGAEDNNLKEMLDYLYQMMNMKENTSS", "function": "Stimulates the release of gastrin and other gastrointestinal hormones.", "AFDB_id": "AF-P29007-F1-model_v4" }, { "swissprot_id": "B0R5M0", "sequence": "MVFKKVLLTGTSEESFTAAADDAIDRAEDTLDNVVWAEVVDQGVEIGAVEERTYQTEVQVAFELDGSQ", "function": "May function as storage protein that sequesters riboflavin and related compounds, thereby protecting the cell against undesirable reactions mediated by the free flavins. Binds and sequesters riboflavin, lumiflavin and lumichrome. Can also bind FAD and FMN (in vitro), but has low affinity for FAD and even lower affinity for FMN. Protects bound flavins against light damage; Trp-36 rapidly quenches the flavin excited state. Promotes the conversion of bound riboflavin to lumichrome.", "AFDB_id": "AF-B0R5M0-F1-model_v4" }, { "swissprot_id": "Q05090", "sequence": "MSGSKLSTPNNSGGGQGNLSQEQIITGTREVIKGLEQLKNEHNDILNSLYQSLKMLKKDTPGDSNLVEEKTDIIEKSLESLELGLGEAKVMMALGHHLNMVEAEKQKLRAQVRRLVQENTWLRDELAATQQKLQTSEQNLADLEVKYKHLEYMNSIKKYDEDRTPDEEASSSDPLDLGFPEDDDGGQADESYPQPQTGSGSVSAAAGGYEIPARLRTLHNLVIQYASQSRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAGNLLHDALAIREKTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEWYYQRALEIYEKKLGPDDPNVAKTKNNLAAAYLKQGKYKAAETLYKQVLTRAHEREFGLSADDKDNKPIWMQAEEREEKGKFKDNAPYGDYGGWHKAAKVDSRSRSSPTVTTTLKNLGALYRRQGKYDAAEILEECAMKSRRNALDMVRETKVRELLGQDLSTDVPRSEAMAKERHHRRSSGTPRHGSTESVSYEKTDGSEEVSIGVAWKAKRKAKDRSRSIPAGYVEIPRSPPHVLVENGDGKLRRSGSLSKLRASVRRSSTKLLNKLKGRESDDDGGMKRASSMSVLPSRGNDESTPAPIQLSQRGRVGSHDNLSSRRQSGNF", "function": "Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.", "AFDB_id": "AF-Q05090-F1-model_v4" }, { "swissprot_id": "Q04TD5", "sequence": "MRMIRFRKKIPYLRYLEMQEKLRKFRRECILFLEHAPIITGGINYNPENLLLGKEFLESQGIQVHFVQRGGDFTAHEPGQLVIYPHVDLKKRNLPIRFYLENLLQSVIDSARTTWGLNLITDSDSPGLYLESNSSKKICSIGVNFKSFFTSHGVAFNLNNDFTAFRCINPCGRNWTDMTSVEKLGLDSGFAKRNQFISFMKANLNSFLGPISKLTHTVI", "function": "Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.", "AFDB_id": "AF-Q04TD5-F1-model_v4" }, { "swissprot_id": "Q59SU1", "sequence": "MRLNSVALLSLVATALAAKAPFKIDFEVRRGESKDDLSPEDDSNPRFVKRDGSLDMTLTNKQTFYMATLKIGSNEDENRVLVDTGSSDLWVMSHDLKCVSAPNSKRNERSFGHGTGVKLNERELMQKRKNLYQPSRTIETDEEKEASEKIHNKLFGFGSIYSTVYITEGPGAYSTFSPFVGTEGGSGGSGGSNTCTSYGSFNTENSDTFKKNNTNDFEIQYADDTSAIGIWGYDDVTISNVTVKDLSFAIANETSSDVGVLGIGLPGLEVTTQYGYTYQNLPLKLKADGIIAKSLYSLYLNTADAKAGSILFGAIDHAKYQGDLVTVKMMRTYSQISYPVRIQVPVSKIDVESSSGSTTNILSSTTGVVLDTGSTLSYVFSDTLQSLGKALNGQYSNSVGAYVVNCNLADSSRTVDIEFGGNKTIKVPISDLVLQASKSTCILGVMQQSSSSSYMLFGDNILRSAYIVYDLDDYEVSLAQVSYTNKESIEVIGASGITNSSGSGTTSSSGTSTSTSTRHSAGSIISKPVYGLLLSLLISCYVLV", "function": "Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Involved in triggering host polymorphonuclear neutrophils chemotaxis toward germ tubes. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein. Required for cell surface integrity and cell separation during budding.", "AFDB_id": "AF-Q59SU1-F1-model_v4" }, { "swissprot_id": "Q2TNK5", "sequence": "MRSAPTARAALVLCAATAGLLSAQGSPEPPEAPRFASWDEVNVLAHGLLQLGRGLREHVERTRGQLGALERRLSACGAACKDPEGSAVPPLTAGNLVPSQSDAAPETLHSLQTQLKAQNSKIQQLFQKVAQQQRHLEKQHLRIQNLQGQLDHLAPMHLGHGVAKAARRKRLPKMTQPAGPAHNISRLHRLPRDCQELFEEGERQSGLFQIQPQGSPPFLVNCKMTSDGGWTVIQRRQDGSVDFNQPWEAYKDGFGDPKGEFWLGLEKVHRIMGDRGSRLAVQLQDWEGNAESLQFPVHLGGEDTAYSLQLTAPVASKLGATIDTPSGLSLPFSTWDQDHDLRGDKNCAKILSGGWWFGTCSHSNLNGQYFHSIPRQREQRKKGIFWKTWRGRYYPLQATTMLIQPTVAEAAS", "function": "Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.", "AFDB_id": "AF-Q2TNK5-F1-model_v4" }, { "swissprot_id": "A0A3G9HHK2", "sequence": "MSVVRPKKVFQTPIDPGVSLRRKKDFYIWAATIGFAQLWRDIKAFKWYRPLQMADLASHYFYIPLGRLDPRILSSAPNDRMLIKTIPHEMSQDYDETGILGCPGREVVNAGSNNYGGFTRFEYGSASVIKLALRNLPFNPAPEELNTLVEREMADYMEADACATAISGYGANLLAFLTVAETAKLSDRQCIFLLDEESHSSMFVGAFLNKEAKFHRFKHNDIADLEYKLRTMKETSPNALVCVAIEGMYSLAGNVAPIPAILALRKVFNFCLLVDEAHSFMAIGCKGRGSFEWWQARGYECPLSEVDIMTATLSKSVGCTGGLVMANKIYASNLQHQARLQREEGDECLSTIVLFRALTLIRKPLFIERRMKTLEEKARYVAERLDEAGCLLLSPPGSPIICFPVGTVQQASNFVAECLKKGFAVACGVPPATPIWSCRVRVCIFATTSWGDILALVNTLIAVSCKLRIDGVQSMKFDTDSLPKVSIKEDIVSDEGNAADLALQEYVEQLAAKYPAEDCRAIAPLNVAQAREVFEYGVQSFEMYGIGASSVRWFYGTFDVFIRLEQRLAGLYPSLISHSGKCRAMLGSDANVMAVSLLSAVAGPMYAKDVLNLVLVPQNAPCYVKKGATLDKVQPSTRVTLYEDLRDLEVEGTKLQKHRYYHVTLYLETVDEDGSILDLSNRIKDILLTLKNAPSLTGLRLILDDSRGLGKIGPRHLGFLDQMESQHGVSFFSTALGPQLAAITTVVVFGSWFHSLNHQGGYVISSEAFTEAHTVSSKSFVFSTPPMIVQAAMSEKTLELLAGGSGLV", "function": "Aminotransferase; part of the gene cluster that mediates the biosynthesis of the host-selective toxins (HSTs) AAL-toxins, sphinganine-analog mycotoxins responsible for Alternaria stem canker on tomato by the tomato pathotype. The biosynthesis starts with the polyketide synthase ALT1-catalyzed C-16 carbon chain assembly from one starter acetyl-CoA unit with malonyl-CoA extender units. ALT1 also selectively transfers methyl groups at the first and the third cycle of chain elongation for AAL toxin. The C-16 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of glycin by decarboxylation, on the carbonyl carbon of polyketide acyl chain (Probable). This step is probably catalyzed by a pyridoxal 5'-phosphate-dependent aminoacyl transferase ALT4 (Probable). The respective functions of the other enzymes encoded by the cluster have still to be elucidated (Probable). The sphingosine N-acyltransferase-like protein ALT7 seems not to act as a resistance/self-tolerance factor against the toxin in the toxin biosynthetic gene cluster, contrary to what is expected (Ref.5).", "AFDB_id": "AF-A0A3G9HHK2-F1-model_v4" }, { "swissprot_id": "P40325", "sequence": "MSKDTHDDELPSYEDVIKEEERLQSQPPRPPRPAANLAQGHQSRPHQRPSTMPATSSSQTYAHSHSYTPTSSQPRPPPRPQQNPSLPWTYPPRFYCSKCGNTGYKLKNGRSCKSCWRRFAPQNNVVSAPTYYTNYTMPVYTNAWQGNRPLYVQPGDPRLGGVLCGECRGSGRTRFLLDEDICPLCHGVGRIITQPQRY", "function": "May be involved in assembly and disassembly of the actin cytoskeleton.", "AFDB_id": "AF-P40325-F1-model_v4" }, { "swissprot_id": "Q6L6S1", "sequence": "MISVALIILFLAKVISGKSDDFISVNPETNMLIDGYGRERFFHGTNVVVKHFPFHPETTGFNKDTFSEDDMKILQKFGLNSIRLGMMLPGYVPKREEYNETYIKVIQSIVTTAAKYGIYTLLDMHQDVFSPKFCVEGMPDWIVNTQGAKDFPMPLHKPFNLDPKTGYPYPEDCAKFSWADYYFTEAAGQAFQNLYDNVDGLRDEWAQFWKKTADVFKEEPSVIGYELINEPFCGNVFKHPTLLIPGVADYLNLQPTYDALQKAIRQVDEEHNIFFEGVTWDFFEVGFTEVPGGKQYQNRSVLSYHYYEPPDFSKKLNFEARLLDLKRLKCGGFLTEMFTVGTDFNSMFEMFDLCDKFKQSWHGWMYKSYGCIEQNLGCLNMSSPGKESIQIANTSRTYPQAVAGRTQSYAFDIKTKVFTLVYETVGSCKSGRTIVYFNKNLHYPNGYRYEINPNFKVTPSENEYFLYLDEVNKVPNTVVTFKLFPLSFTDSEDIHPVTVMGDKHLSENHNENEKKKK", "function": "Hydrolysis of the glycosidic linkage between oligosaccharides and ceramides of glycosphingolipids, optimal substrates appear to be the glycosphingolipids with a gangliotetraose structure.", "AFDB_id": "AF-Q6L6S1-F1-model_v4" }, { "swissprot_id": "D0RLZ2", "sequence": "MSKLFYAFAVLAVHVLTSSPTTAASNLPVNLVTGPAFTTPAGAAHRRFLRSIHEGEDSLKPSAFSEERTALRAMDYLLKPKHKKLAAALKKSTSKHKLSVAPEKMKSIQVLGDPKNPEREWFKRLYNSKRGDPQTLRKLGQFKTEAQLSRYIKFYVVCRTCIACYSSGRSDSCHRTPRMVRTVGVGCRD", "function": "Effector that is involved in host plant infection. Contributes to virulence during the early infection stage, by inhibiting plant defense responses induced by both PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI).", "AFDB_id": "AF-D0RLZ2-F1-model_v4" }, { "swissprot_id": "P01068", "sequence": "MNMLLLFLHEVINGERVTLTACSECVCPLQTSSSDDEYKCYCADTYSDCPGFCKKCKAEFGKYICLDLISPNDCVKPVSSSEAKQKMIKGERVTLTACSECVCPLRTSSSDEEYKCYCTDTYSDCPGFCKKCKAEFGKYICLDLISPNDCVKPVSSLEAKQNMIKEERVTLTACSECVCPLRTSSSDEEYKCYCTDTYSDCPGFCKTCKAEFGKYICLDLISPNDCVKPVSSWEARQKIKLLQGRE", "function": "Weak inhibitor of cysteine proteinases.", "AFDB_id": "AF-P01068-F1-model_v4" }, { "swissprot_id": "P53090", "sequence": "MTLPESKDFSYLFSDETNARKPSPLKTCIHLFQDPNIIFLGGGLPLKDYFPWDNLSVDSPKPPFPQGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTPGAPKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEFKTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTLYEEFGISK", "function": "General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Responsible for phenylalanine and tyrosine biosynthesis. Active with glutamate, phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate, 2-oxoglutarate and pyruvate as amino acceptors. Also active with methionine, alpha-aminoadipate and leucine as amino donors when phenylpyruvate is the amino acceptor and in the reverse reactions with the corresponding oxo acids and phenylalanine as amino donor. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the formation of alpha-aminoadipate from alpha-ketoadipate in the lysine biosyntheic pathway.", "AFDB_id": "AF-P53090-F1-model_v4" }, { "swissprot_id": "B0UHI1", "sequence": "MGNDKTNMIIAIALSLAVLLGWNYFVTAPQVERQRQQQAAQVNPSQGVNPSQGVDPSQGVNASPSPKEGGPSAPVPGTLPGAAGGSPQAALARDEALARAPRVRIDTEALRGSVALKGGRIDDVALKGYHETVDPKSPEIVLLSPAGSANPYYAEFGWVGQNAGPLPGSDTVWTADGDVLTAKKPLVLTFDNGAGLVFRRTLSVDDKYMFTIEDSVENKGPNPVTLYPYGLVSRWGKPHTQGYYVLHEGMIGVVGDKGLQEYTYDKMAKENPLGAPGTRGVSWPGATGGFLGITDKYWAAATIPDQQAPYTGSFTERDEGATKVYQASSLGEARAVAPGASVQASQRLFAGAKEVSTVDAYREKLNIKQFDLLIDWGWFYFITKPMFKALDLFYKLFGNFGVSILVVTLILKLFFLPIANRSYVSMAKMKAVQPEMTAIRERYADDKVKQQQAMMELYKKEKINPVAGCWPVLIQIPVFFSLYKVLFVTIEMRHAPFFGWIRDLAAPDPTSIVNLFGLLPFTPPDLLHLGVWPIVMGITMFLQMKMNPAPPDPVQAQVFTFMPIIFTFMLGSFPAGLVIYWAWNNLLSILQQYWIMRRNGVKVELWDNLRSTFQRRTQVKTAKG", "function": "Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.", "AFDB_id": "AF-B0UHI1-F1-model_v4" }, { "swissprot_id": "Q55DK5", "sequence": "MTVDNSQIPNLNQPESFADLWDGYENVSKATEKGVLLLKDITKFFKKRIQSEDEYSKTLSKLVLKFEPMAPDGYIGPRLKNTWDQIKLETLTHSNHHENICNNISTHIIEPIEGLIVDLEQKMKSIHVDAEKSFIHYQESVAKLKKAKQNYDRLCKDSFEITGVSKGETQKVQKRAIKAAQDVIKADKDYRAQINETNTSQKQFLTELIPKIMNDLQRLEMVRIHMVKSYFHRYFKSMESTPQKFNTETENLLNLINSINNEDEIQDFVRKSKTTHKYPKPFEYEPYLDRFTTPPPPPPPQISSPQLLSPRGDISIQHSSSSNSLPIFPTQHQLLSNKEKADNNITNSLSLSSDSLQTNLNNGNNGGNGNNGSNTPTKEKKPSSWGLKRFSTSVSSTSDRKLLNKQIQSIGLAHNGGNIFNCKIEDIMVAQKKKYPYLEIPFIVVFLKHKLVALDVFKTQGIFRVPGNVVDINSLKKRFDEGNYEVAPTENVYTIASLLKLWLREITEPLFPLTVYDQCIENSNKREKIFEIISSLPILNQKTISYIIELLQECGKSVNVEHNKMNFPNLAMVFSPCFLRCSHTDPNILLGNIFKEKEFVQNIIEHFKPLQVNDSLEGPPSSSSSSSTSINQSSIESPPTSPLRSSTNSNANKSSTPIKPSSPSQQQQQQQQQQQSSTPSTPLSSTTNTNVKHNILSPIVEQQSPNNGKQPIALTQTYSHLNIGSVPLIINTVNNNNQNQNQNQNQNQNQDQNQNQSKQPIQSSNQTQQQVSAPATPHTVAVNPKINQIKAETITTPQKSIGDGNGLIGQSPSAHLMSPSEVKRRSNAIYLEDQERCKQRIDELHTQVNELYSDITTIETTTYFAMQSSLLITKLTKSLESFLTIDMWNLTLQDIKEAIEKNKFVSPPPINFKIPSKMPKLSPIELVQNEQSSELLRSWLSNVTLTVNRINEYLCYLGGVVIRIHSPDTLFAISNLFTDYDLSPQQNPKFVSLTLEQSTIFIQKTLALLEPLNPFTSDELNINVKVQDTITPASFSPALISDPDCNSPPTISNTTNRLLNTSGSTDFSTTPLSSSPSTSSTSLSTNNNNNNNGNRNLDINNSPTIVITNSSLNKSALSTNNNNNNNNNNNNNPTTKLSSSTSSTSTTTTTNTNTNTTTNEKIAHAIISPSSSTTSFKFDDDEDEDEDLLEINNKLHSQLTEELKKKQQQYKQLIFDIIDMIKDKKKLMNSLDLTNSDSQLDIKSIAKLSLSLKRALDNFTSESGFDIEDEQDPIINKENDSFVNLKIMTSHFISRIVLILTTILSISNEFNSTLYQLLLPFNENNNNNNENNNINNQ", "function": "Rho GTPase-activating protein involved in the signal transduction pathway.", "AFDB_id": "AF-Q55DK5-F1-model_v4" }, { "swissprot_id": "Q03175", "sequence": "MKMPSIIQIQFVALKRLLVETKEQMCFAVKSIFQRVFAWVMSLSLFSWFYVNLQNILIKALRVGPVPEHVSFIMDGNRRYAKSRRLPVKKGHEAGGLTLLTLLYICKRLGVKCVSAYAFSIENFNRPKEEVDTLMNLFTVKLDEFAKRAKDYKDPLYGSKIRIVGDQSLLSPEMRKKIKKVEEITQDGDDFTLFICFPYTSRNDMLHTIRDSVEDHLENKSPRINIRKFTNKMYMGFHSNKCELLIRTSGHRRLSDYMLWQVHENATIEFSDTLWPNFSFFAMYLMILKWSFFSTIQKYNEKNHSLFEKIHESVPSIFKKKKTAMSLYNFPNPPISVSVTGDE", "function": "With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).", "AFDB_id": "AF-Q03175-F1-model_v4" }, { "swissprot_id": "Q5R7C1", "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.", "AFDB_id": "AF-Q5R7C1-F1-model_v4" }, { "swissprot_id": "Q9I322", "sequence": "MKIESISPVQPSQDAGAEAVGHFEGRSVTRAAVRGEDRSSVAGLARWLARNVAGDPRSEQALQRLADGDGTPLEARTVRRR", "function": "Acts as a negative regulator of the type III secretion regulon (T3SS) expression. In the absence of inducing signals such as low Ca(2+) or host cell contact, the T3SS/injectisome is expressed at a low basal level and exists in a quiescent state due to ExsA sequestration by ExsD. ExsE binding to ExsC disrupts the complex between ExsC and ExsD, thereby allowing free ExsD to bind ExsA. Upon inducing signal, ExsE is secreted allowing ExsC to bind ExsD. In turn, ExsD cannot bind ExsA and prevent ExsA-mediated transcriptional activation of the type III secretion system.", "AFDB_id": "AF-Q9I322-F1-model_v4" }, { "swissprot_id": "Q30PQ0", "sequence": "MKRGSVALFAISFFAFGWMTHALYNDAYKMIKESTLKKIKKSGALNVVLLNAPSTYYIGSDGPKGFEYDLLESYANHLGVKLNITTANTIKEALELSKNPDIHITSASLTKTPEREKEFNFGPSYFEAQEQVVCNKSLLLDGRFPSDADSLSGLRVVVGDSTSYSETIESLKKEGFDINATYTAEYSTEELISQVDTHEIDCTIIDSNIYALNQRYFKNIVLAFDISNRRQQAWILTPDSKMLKNDMYSWLNTVNQSGEMARLKDHYYSYVLFFDYYDTVMFYKRIKTRLPKYESYFKEAAVKYEIPYSALAALSYQESHWNPNAVSYTGVRGLMMLTQDTASMLGVKNRIDPQESIFGGAKHLDQMIKSVHADVTGEDRLKFALAAYNVGLGHVADAQKLAQQLGLNQNSWADLKKVLPMLSQKKYYRTLKHGYARGNEAVKYVDAIYDYRDILQKNDVEVSLTTK", "function": "Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.", "AFDB_id": "AF-Q30PQ0-F1-model_v4" }, { "swissprot_id": "P82191", "sequence": "MAAILPTFSIKSSSCTYSSSKRSLSSPKAVSLSSSVNGTPKVQSLRLSTSFVCSPNQIIKLKSVSPSRSTQLRRAVGGLEIKMMSVDAGIGVMGTKLGMMSFFEEDGTVVPVTVIGFKEGNIVTQVKTESTDGYNAVQVGYERLRDRKLTMPERGHLNKAGVIPMRHLQEFRLVSVDDFTPSQKLLFEELFKEGDMVDISGTTIGKGFQGGIKRHNFKRGLMTHGSKSHRALGSIGAGTTPGHVYKGKKMPGRMGGTKTKIRKLKIMKIDTDLRVVMIKGAVPGKPGNLLRLAPAKIVGKNIPKN", "function": "Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.", "AFDB_id": "AF-P82191-F1-model_v4" }, { "swissprot_id": "Q86AG8", "sequence": "MMRSDISNQISQELNNTNINLNGKSFNDYKFKEPIKDYSRYLSLRNSTPCQLTEVEISTFLASSEILSFGAGIPSKLFFPIKELEFNFNFLGNEKVRLSKEDLDLVQQYSDSPGLPKLRNWCKSIQQRHHGLCDPNTPGKEWNLLMTPGSQHALDCLVKAFFNRGDTLIVERYTYGGMFAVTQPSGINFAACEMDSKGMIPSELDNLLSNWESTHPDLKFPKLIYMIPHGQNPTGILYDMERKEEIYKIACKFDLLIIEDDPHFFLQLDNEIVNGKRVLNKSFLSIDKEDRVIRLDTFSKFLSSGIRMGFVTTNSKLFGVIAFELNASIFHSSGLTQIALEKLLTNWGDEKFDSHVNFVQEVLIRKRRETIELLEKHLKGQVEYSVPKAGLYFWVKLLGIDCSYEFVRDVLRHHKVIFGLGISSSPNRTIKTPYIRVTFSYLEKEDGEVAFKTLSDCLKDYIKNKKIIKHDEDVTLYNNIS", "function": "Has aromatic amino acid transaminase activity.", "AFDB_id": "AF-Q86AG8-F1-model_v4" }, { "swissprot_id": "P40071", "sequence": "MRVRPKRSVITLMAIVVVMLILRNQFYSSRTRGHGQEPVISSSQKNLYDGWITPNFYRKGDPLELIVNKVESDLTQLPYAYYDLPFTCPPTMHKKPLHLSLNEIIRGDRKWESDYKLKFGEDNPCETLCARKTTKEGMQTLDKLVREGYVVQWLIDDELPAATTFISTTDHKKYYASGFPLGFIDPDTDKTYLHNHVMLVIRFHASDNDKNTIVGFEVYPRSVSDYHCPGASKNYEQYEIVIPEDENELTYLPFTYSVYWREEFEVDWNHRWDYFLNAGELSDEQSIQFHWMSLANSVGIVLSISFITLIIYVRVMYTDKSNSKSPKYMINIEGIETEDDLDDDKYGKYSVYTVAKDWIQNGRPNLFGLKVLILLVSFGVQFLFTIIGSLTISCSMNKLHNVRNSVLTMAILFFVLGAFMASFVGTRLSMVTKTKRTKANYLDDNRYLKDYKKFSPIFTILCGSSLPGIVMVSTFLLNSIVWAHDSTSALPFKTIVFFMSIYFIVCIPLSLFGGIVANNIPLPQYWLSGITKDESNSDGNGLFVPKSRAKFNPLVYCGIYLCGIFPLLVIYVEMQYVYKSLWLEKTTFYYFYGFLFLSIILLCVLTMEISIIGSYLLMRFCFEDKVVRNNWRWKCFEMGFSGGVYMELYSLYYIFAVLNIHGFSSILISICYSLIFNVMCSLGLGALSYLTASWFINKIYHQKVNL", "function": "With EMP70 and TMN2, plays a critical role in the late stages of a nutrient-controlled pathway notably regulating FLO11 gene expression. Acts downstream of RAS2 and TOR. Essential for cell adhesion and filamentous growth. May play a role as effector of cellular copper homeostasis.", "AFDB_id": "AF-P40071-F1-model_v4" }, { "swissprot_id": "Q5TZF3", "sequence": "MESEGPPESESSEFFSQQEEENEEEEAQEPEETGPKNPLLQPALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQLEDIVTPIFTKMTTPCQVKSAKSVTSHDQKRSQDDTSN", "function": "May play a role during cell division.", "AFDB_id": "AF-Q5TZF3-F1-model_v4" }, { "swissprot_id": "Q8VID5", "sequence": "MSARPFSTPFDRERRVRSTLKKVFGFDSFKTPLQESATMAVVKGAEDVFVCMPTGAGKSLCYQLPALLASGITIVVSPLIALIQDQVDHLLALKVQVSSLNSKLSVQERKELLSDLERDKPRTKLLYITPEMAASASFQPTLNSLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDVFAALHLKQPVASFKTPCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQKAENGSSSGCGIVYCRTREACEQLAIELSSRGVNAKAYHAGLKASDRTQVQNEWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKPSDKATLLAFDALVTFCEEVGCRHAAIAKYFGDAPPACAKGCDYCQNPAAITKKLDALERSSSWSKTCIGPSQGNGFDPELYEGGRRGYGGFSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMSLRKGKEPKIEEFTPPDEDCPLREASSRKIPKLTVKAREHCLRLLEEALISNHQAAGSTHGADLQAKAVELEHETFRNAKMVNLYKASVLKKVAEIHKASKDGQLYDMESGTKSCGAAAEFSEPSDYDIPPTSHVYSLKPKRVGAGFSKGPCSFQTATELLGKSHSQKQAPEAMLEGGQEPPGWVCDLQDEDRSKPHPGYQEKALGSSVNCGDPSPEKKTKGSSQGSAKARASKKQQLLATAARKDSQNITRFLCQRTESPPLPASVPRSEDASPSCGDVPGKCTQEVGAQGHLVAVFQTEGPRERPSTCSLRDQSFPEGQPSPLKETQAEKRPRPQQGNPERRAQKRLRPSTKSSILAEAKDSTLASDRSTENKVAQEPCQLSASGTSLREAADIVVRHLTPFYKEGRFISKDLFKGFARHLSHLLAQQLSPGRSVKEEAQSLIKQFFHNRARCESEADWHSLRGPQR", "function": "DNA helicase that plays an important role in DNA replication, transcription and repair. Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Associates also with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.", "AFDB_id": "AF-Q8VID5-F1-model_v4" }, { "swissprot_id": "P97577", "sequence": "MEAPLVSLDEEFEDIRPCCTEDPEEKPQSLYGTSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLRDEEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDTEIHEKEEEDEFIEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEVEVLEEEDGGEISSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT", "function": "May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.", "AFDB_id": "AF-P97577-F1-model_v4" }, { "swissprot_id": "Q9BWE0", "sequence": "MLERRCRGPLAMGLAQPRLLSGPSQESPQTLGKESRGLRQQGTSVAQSGAQAPGRAHRCAHCRRHFPGWVALWLHTRRCQARLPLPCPECGRRFRHAPFLALHRQVHAAATPDLGFACHLCGQSFRGWVALVLHLRAHSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICGNCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPRPRGRPAVTAPRPGGDAVDRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLLSHSKIHKRSEGSAQAAPGPGSPQLPAGPQESAAEPTPAVPLKPAQEPPPGAPPEHPQDPIEAPPSLYSCDDCGRSFRLERFLRAHQRQHTGERPFTCAECGKNFGKKTHLVAHSRVHSGERPFACEECGRRFSQGSHLAAHRRDHAPDRPFVCPDCGKAFRHKPYLAAHRRIHTGEKPYVCPDCGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKSNLITHRKSHIRDGAFCCAICGQTFDDEERLLAHQKKHDV", "function": "Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending.", "AFDB_id": "AF-Q9BWE0-F1-model_v4" }, { "swissprot_id": "C8VJR5", "sequence": "MASPASITLAEVARHSSPNDLWIVIEGNVYDVAEYREDHPGGDEILRQFAGKDATTEFQDAGHSNDAYVKLKTLLVGSLQSKTLPENQPEESSRIVSIAVSDRGKIPTKRQARNGNDTSKYGQLPSLVLAGGLALLFFTLKQHPWQSIQGYLSQAQVSRVQSSGWVGFLGGFLTATTLNTAAATFVGLTAKKTLLLRHRELEEYPRVKQHYLPLPPKKPGISGENTQQFLTLVDRQCIAPNVYKVRLQGDGLVIGLGQHLKVLAEIDGRKIQRSYTPVSPVGNSPKVDLIIKVYPKGQLGNYLLNLPLQSRVEIRGPFGRYSPSPTWKHIACIAGGTGIAPIYQVMRAWPGEITLLYGNETWEDILLREELEQLVLQSPRRIKVHHVLGQPKSDWKGLRGWITREMIQDLLPEPSSSTGFLVCGPDGMVRAIRGHFEAIDANGEEKANVFVF", "function": "NADH-cytochrome b5 reductase-like protein; part of the gene cluster that mediates the biosynthesis of asperlin, a polyketide showing anti-inflammatory, antitumor and antibiotic activities. The first step of the asperlin biosynthesis is the production of the intermediate 2,4,6-octatrienoic acid by the highly redusing polyketide synthase alnA with cleavage of the PKS product by the esterase alnB. 2,4,6-octatrienoic acid is further converted to asperlin via several steps involving the remaining enzymes from the cluster.", "AFDB_id": "AF-C8VJR5-F1-model_v4" }, { "swissprot_id": "G3J454", "sequence": "MECTTVKLSVALGEEVVQLSTLDQQAQRAYANLLLVFKLSQNADADHVFSSLKRGLGAALTEVPDFASLVVPVPGSKKNELQLRLGPDSGVPFKLVRQDALASHLEKHSSGGTYAELARDNFPLASVPTELLFNQLPASELACARGLPGLLAQASVVDGGLIMGLSWHHTVSDARGINTLLSSWARHTKMWAGQGTIGSPSAAPEPTRDRWRLTCGPRDVHVSHFSDYQINAAARTPLSPAAAHLLDRPDTTNATAGLSTWYFSKKALSSLRGELGRAAADGSDAVQFTSGEAVSALVWKHLSLARLLHQQLAHETSLFASRIDFRGRAKPAFADGYIGNINEPNARTRMRLAEVCAPSSPASLVALAAAVREAIGAMDEKTMREFIGLVEGSSSVTDVYWDYNTFPGPDLVVTDMSGMDTLRQEWGGDLGQPVCIRSGSREKGVAYFLPQDAQGGFEVQLQCTAEDLGRLKDDSLFTKYAEFRS", "function": "Acyltransferase; part of the gene cluster that mediates the biosynthesis of beauveriolides I and III, cyclodepsipeptides acting as inhibitors of the acyl-CoA:cholesterol acyltransferase. The HR-PKS cm3B initiates the biosynthesis of beauveriolides by iteratively catalyzing the formation of the linear polyketide chain (Probable). The ATP-dependent acetyl-CoA ligase cm3D converts the polyketide carboxylic acid to a CoA thioester which id shuttled to the first T domain in the NRPS cm3A by the acetyltransferase cm3C (Probable). Cm3A contains 13 domains and assembles the polyketide chain, L-phenylalanine, L-alanine, and D-leucine (or D-allo-isoleucine) to form beauveriolide I (or beauveriolide III). The production of both beauveriolides I and III suggests the substrate adaptability of cm3B, using different amino acids as substrates (Probable).", "AFDB_id": "AF-G3J454-F1-model_v4" }, { "swissprot_id": "A0RVX9", "sequence": "MTAVKSVIRENYNMMKLREFLRENIKDSGFSGVEVEKNPRGTKITLHVTRPGIVIGRKGVGIRELTERLEKDFDLKSPQVDVKEIETPELYPGVMCNRMASHIERGTAFRRATMWTIQQIMEKKDAMGVQITISGKLRGDRSAFEKHTSGILPRAGHYADVIVLDDVVHVKTPMGLIGIRIRIARRDKFRKDFEMKAEKDVVPAPKPEHHDVKDETDPSAGTEAKDGAAAPKAGSESEQVEIEEEAMKSINTMEEDEEKLK", "function": "Binds the lower part of the 30S subunit head.", "AFDB_id": "AF-A0RVX9-F1-model_v4" }, { "swissprot_id": "A9GMG8", "sequence": "MDQFKTHVLGLASLSLALLVALPARGASLQKVNQSEWGADGLPSYVNMYIYVPDKLATKPPIVVAPHHCQGNGQGTFSEMSSLVSIANTSGFIMIFPEATGQNCWDAGSTRSLNHGGGGDTGAIVQMVKYTLAKYGGDAGRVYSVGGSSGGIMTEALLGVYPDVFMAGVSLMGVPCGCWAEGYNDVTGTGSSAQWSGPCGGGNVTKTGQQWGDLVRSYYPGYTGHRPRLQHWHGTADTILSYKNMAEDIKEWTNVLGLSETPSGTDTPKRGTTRQFWKSACGYTVYEAFSMDGVGHAVPFDGPAVAAYFGLDRAGGQDPETAACPGAVPGGSDTGGAGGATGAGGAGGEAGTGGAGGEVGAGGAGGEAGAGAGGAGGVTVSGSGGSAGSGGAMDTASGGANGQDASAGTGDSTGGEGSSSGCSCAVGNDARDAGAQAGFLLAALGLLLGRQKRRPR", "function": "Esterase with broad substrate specificity, that may be involved in degradation of plant biomass present in the habitat of S.cellulosum. In vitro, displays acetyl esterase activity, aryl esterase activity, paraben esterase activity, carboxyl esterase activity, poly-3-hydroxybutyric acid (PHB) depolymerase activity, and a low feruloyl esterase activity. Does not possess any paraoxonase activity. Is able to bind to multiple substrate molecules simultaneously.", "AFDB_id": "AF-A9GMG8-F1-model_v4" }, { "swissprot_id": "A8EXV6", "sequence": "MKLSDFDFDLPSELIAQYPSSKRDHSDLLIAATPPIKTKFYNIIDYLKEGDLLVFNNSKVIKAKLNLEKNRPLSKLAYRDKFEGDMECRTAVYTNVREDSSTGSTYKLPLEVELEKRSNITINLNQRLSNNCWSAFAKPARRLNIGDEFHFDNHKVIIVEKLAIGEIKVKFELDDISVFEFLDKYGEMPLPLYIRHHEAQKSNNERYQNIYSSIEGSVAAPTAGLHFTNDILNKLKAKNIQTTFLTLHVGAGTFLPVKTENIHEHKMHTEYCSITPDTARLINKAKQEKQRIIAVGTTTLRTLESSCNNGTVKACDFETDIFITPGFKFQTADILLTNFHFPKSTLFMLICAFAGFKEMHKLYKYAIKEKMRFFSYGDATLLYRKI", "function": "Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).", "AFDB_id": "AF-A8EXV6-F1-model_v4" }, { "swissprot_id": "Q6CTF5", "sequence": "MLSVRISARQCSVRGLATQANNVSQPAKDNATNGSDAATEKKGTARYQRIQPSVALNSLKTKLSNDFQKQQPAQKIYSQFQSDLQQLISEQQVNPRHFVNSSICNSVLAKLILQSKSELDGQSIGESASIPPTPFEILETYLKYNLARHQHFIIVLKQFLIDLQPKEAINLWISFLEHAKQMPLNNTGTSQVQALTSIAYLMLSKESNSAPDVNVLTQLLNITPSKVPFLAIEQEIKSLGLTATTKDELLKSFDDLLLQWFTADKDAFINEFLKNSNDLKLITYLWKQYLKLATKDFTTSNQEIPGAFMIKLAQLDRSLDAVKIMTQLKEASADFKPSVSLYNSLLQTVAYIPAFGKEAQSIKLNRIQAIWNSYIKSSGNITVASYKAMLEALIIAGHFKTVESFWTLDVPDDVKANSEISDIYLKNFFASVKKVHFSQLKSKIPSKVHNLELANTILLAMVHSDASVGDIDSFYSHTFQSTEGIKPNDKTLAIKLRANLAAFGDSKNESILGTIGLSANSPTATLVIEEFLKICENEESATALLKALNIDNKSNDSAKKVSNFLDYYLQHGNWEYAEELFKKYLTDNVKSPSSVNYRLFNSMFKGFSELSITRNDTGFVSKQQVYWELCQRIHNRIFNECVISTLKSVSALSRRNAEFSENELDFINNTVLPYLVKLKIENSFKLQNPKYLQNMKSNDKIHIPKELL", "function": "May be involved in the control of meiotic sister-chromatid recombination.", "AFDB_id": "AF-Q6CTF5-F1-model_v4" }, { "swissprot_id": "Q55080", "sequence": "MYDWFSEMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSLLDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKFKEWSDLVAFRLGKPGEIFELGKKYLELIGYVKDHLNSGTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRFNLWQRIREENLYLKAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDRNPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKVPNEVLNGYKRLVVRLKSNE", "function": "The endogenous substrate is not known. In vitro, catalyzes the H(2)O(2)-dependent epoxidation of styrene, cis-beta-methylstyrene, and cis-stilbene with retention of stereochemistry. Is able to use cumene hydroperoxide (CHP) or tert-butyl hydroperoxide (TBHP) instead of H(2)O(2) as the electron acceptor. Can also hydroxylate fatty acids such as lauric acid.", "AFDB_id": "AF-Q55080-F1-model_v4" }, { "swissprot_id": "P53305", "sequence": "MNVPKARLLKVAELSAKIFDQNFNPSGIRTGSKILNERLKGPSVASYYGNPDILKFRHLKTLYPDIEFVDLEEQYRLSMVEAKKRRGKGAPKKMKKDAAATAKGKGKKKK", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.", "AFDB_id": "AF-P53305-F1-model_v4" }, { "swissprot_id": "Q9PN78", "sequence": "MGRSRKNFLSLLENDKVGIFCAFDKDYNVFRAKIHNENLFSHLGFKDIEKCVFMDQIHSHKVIIYDENLKNLSCDGLISKEKNIALCVLSADCLPLILYHESGIIAALHSGRKGSFENILKECVDQITMQNSHLDKNKFHLFILPGICAKNYEIDGEILEFAKKEFKEFVQDDKLDLKALVKFQAQNLGIENIKDCGICSFDDESFFSYRRDKTTKRFVSVVYLKD", "function": "Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.", "AFDB_id": "AF-Q9PN78-F1-model_v4" }, { "swissprot_id": "Q54GV7", "sequence": "MNKRSLENNELNEIQNNQNKNNNNKINKEIPSDNTPLKKLKSINSLEQLQEVDEDEDLDVEIDTKLINKLDKKGRKYEFVGEGYSDEEQISDDYEDDESSEYEYGYENEDELLDDEDHLDNINEIKKIQKKLVNTETSTSITNTSSTTTTSTSTTTTTTTKTQINETILLDILNNNKDEVDDEIQRIGNNVGNSKEEEGEEEEENIELVARSFIYKHIQEKKSLGIDPIEFTKDIGFKLELEKDDDAWEIITAFLTRKKVAVNLFLNYLKYNTLARPYRKKIATLDLSTFEKVCQLFESSKNIVIITGAGVSVSCGIPDFRSKGGVYETIEKKYNLPRPESLFDIHYLRANPLPFFEFAKEIFPGNHKPSPTHSFIKLLDEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHGSFSTATCITCKLTVDGTTIRDTIMKMEIPLCQQCNDGQSFMKPDIVFFGENLPDRFDQCVLKDVKDIDLLIVMGSSLQVQPVSLLPDIVDKQIPQILINRELVAQPHEFDYVYLGDCDQFVQDLLNKVKW", "function": "NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression.", "AFDB_id": "AF-Q54GV7-F1-model_v4" }, { "swissprot_id": "C6Y4D2", "sequence": "MSSIGGKLQKSLHKIRAGALGIPLPKHIQEVSIQYSLDSRLGHMGAKKFVKECLPSLYYNNYGLKFNVNHRLPNDQTPTFSIISNNKVIYSYDMRSKQLETISSDIQKALKELHHESSPENIKEAHKQDYSPPSN", "function": "Involved in mitochondrial translation.", "AFDB_id": "AF-C6Y4D2-F1-model_v4" }, { "swissprot_id": "P40463", "sequence": "MDTSNHNQDHDSHVAAQRENDNNYMPPSPSMSESSMIFERNVEDPSYLYKTVSNNAANSLSRQSSRTSLFNHNNSSNRNFHNLSQRSSAVNLHLQPSRTNESIASYQTYNPDFVVQTPLDHRRTLENFVPPALDAGCSIVTDDTTGLDDVDMVYSRRPSTIGLDRALGRTRSLSSQSFDNETSPAHPRSPNDHGSRLLRFYSYADMLSDDNNNNVSNATSTSSTANPLRRPPMQGHYSFSSSLLNSPSHLPSPPSASASPPQHMNFTNPFIISRRYSNTTINNANGGTSAGSTTGAALSRSPSNQQYLLKQQRSPSGSARSRRNSNRPGSAANIMIGKPKSKFHMESSGSEGFSSEEEDNTMIERDKLNLKQKLQSQLAQPPSIANMVNDNHNNTNKHKNTINNNIKNSPAFTNSNPSSKSNSNSTITSMNPDTTK", "function": "Can suppress the synthetic lethality of the hal3 sit4 double mutation when overexpressed, suggesting that it is involved in the G1-S transition.", "AFDB_id": "AF-P40463-F1-model_v4" }, { "swissprot_id": "P32152", "sequence": "MLNERQLKIVDLLEQQPRTPGELAQQTGVSGRTILRDIDYLNFTLNGKARIFASGSAGYQLEIFERRSFFQLLQKHDNDDRLLALLLLNTFTPRAQLASALNLPETWVAERLPRLKQRYERTCCLASRPGLGHFIDETEEKRVILLANLLRKDPFLIPLAGITRDNLQHLSTACDNQHRWPLMQGDYLSSLILAIYALRNQLTDEWPQYPGDEIKQIVEHSGLFLGDNAVRTLTGLIEKQHQQAQVISADNVQGLLQRVPGIASLNIIDAQLVENITGHLLRCLAAPVWIAEHRQSSMNNLKAAWPAAFDMSLHFITLLREQLDIPLFDSDLIGLYFACALERHQNERQPIILLSDQNAIATINQLAIERDVLNCRVIIARSLSELVAIREEIEPLLIINNSHYLLDDAVNNYITVKNIITAAGIEQIKHFLATAFIRQQPERFFSAPGSFHYSNVRGESWQHITRQICAQLVAQHHITADEAQRIIAREGEGENLIVNRLAIPHCWSEQERRFRGFFITLAQPVEVNNEVINHVLIACAAADARHELKIFSYLASILCQHPAEIIAGLTGYEAFMELLHKG", "function": "Could be involved in the regulation of the transcription of the FRV operon.", "AFDB_id": "AF-P32152-F1-model_v4" }, { "swissprot_id": "Q6F3I7", "sequence": "MRLALFALFALMTVATALPAHAEKLTLEAITGSAPLSGPTLTKPQIAPDGSRVTFLRGKDRDRNRLDLWEYDIASGQTRLLVDSSVVLPGEEVLSDEEKARRERQRIAALSGIVDYQWSPDGKALLFPLGGELYFYDLTKSGRDAVRKLTNGGGFATDPKISPKGGFVSFIRDRNLWAIDLASGKEVQLTRDGSDTIGNGVAEFVADEEMDRHTGYWWAPDDAAIAFARIDETPVPVQKRYEVYPDRTEVVEQRYPAAGDHNVRVQLGVIAPKTGARPRWIDLGKDPDIYLARVDWRDPQRLTFQRQSRDQKKIELIETTLTNGTQRTLVTETSTTWVPLHNDLRFLKDGRFLWSSERSGFEHLYVASEDGSTLTALTQGEWVVDSLLAIDEAAGLAYVSGTRDGATEAHVYAVPLSGGEPRRLTQAPGMHAATFARNASVFVDSWSSDTTLPQIELFKADGTKLATLLVNDVSDATHPYAKYRAAHQPTAYGTLTAADGTTPLHYSLIKPAGFDPKKQYPVVVFVYGGPAAQTVTRAWPGRSDSFFNQYLAQQGYVVFTLDNRGTPRRGAAFGGALYGKQGTVEVDDQLRGIEWLKSQAFVDPARIGVYGWSNGGYMTLMLLAKHDEAYACGVAGAPVTDWALYDTHYTERYMDLPKANEAGYREASVFTHVDGIGAGKLLLIHGMADDNVLFTNSTKLMSELQKRGTPFELMTYPGAKHGLRGSDLLHRYRLTEDFFARCLKP", "function": "Catalyzes the sequential release of Tyr-Pro, Phe-Pro and Gly-Pro from the N-terminus of peptides and proteins. Is able to cleaves bioactive peptide beta-casomorphin.", "AFDB_id": "AF-Q6F3I7-F1-model_v4" }, { "swissprot_id": "Q45340", "sequence": "MYLDRFRQCPSSLQIPRSAWRLHALAAALALAGMARLAPAAAQAPQPPVAGAPHAQDAGQEGEFDHRDNTLIAVFDDGVGINLDDDPDELGETAPPTLKDIHISVEHKNPMSKPAIGVRVSGAGRALTLAGSTIDATEGGIPAVVRRGGTLELDGVTVAGGEGMEPMTVSDAGSRLSVRGGVLGGEAPGVGLVRAAQGGQASIIDATLQSILGPALIADGGSISVAGGSIDMDMGPGFPPPPPPLPGAPLAAHPPLDRVAAVHAGQDGKVTLREVALRAHGPQATGVYAYMPGSEITLQGGTVSVQGDDGAGVVAGAGLLDALPPGGTVRLDGTTVSTDGANTDAVLVRGDAARAEVVNTVLRTAKSLAAGVSAQHGGRVTLRQTRIETAGAGAEGISVLGFEPQSGSGPASVDMQGGSITTTGNRAAGIALTHGSARLEGVAVRAEGSGSSAAQLANGTLVVSAGSLASAQSGAISVTDTPLKLMPGALASSTVSVRLTDGATAQGGNGVFLQQHSTIPVAVALESGALARGDIVADGNKPLDAGISLSVASGAAWHGATQVLQSATLGKGGTWVVNADSRVQDMSMRGGRVEFQAPAPEASYKTLTLQTLDGNGVFVLNTNVAAGQNDQLRVTGRADGQHRVLVRNAGGEADSRGARLGLVHTQGQGNATFRLANVGKAVDLGTWRYSLAEDPKTHVWSLQRAGQALSGAANAAVNAADLSSIALAESNALDKRLGELRLRADAGGPWARTFSERQQISNRHARAYDQTVSGLEIGLDRGWSASGGRWYAGGLLGYTYADRTYPGDGGGKVKGLHVGGYAAYVGDGGYYLDTVLRLGRYDQQYNIAGTDGGRVTADYRTSGAAWSLEGGRRFELPNDWFAEPQAEVMLWRTSGKRYRASNGLRVKVDANTATLGRLGLRFGRRIALAGGNIVQPYARLGWTQEFKSTGDVRTNGIGHAGAGRHGRVELGAGVDAALGKGHNLYASYEYAAGDRINIPWSFHAGYRYSF", "function": "Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.", "AFDB_id": "AF-Q45340-F1-model_v4" }, { "swissprot_id": "D3RW30", "sequence": "MSSRLAVFAYDIRDDRVRRHALKTLREWRLDGQLSVHECQVDAIQARRLFEQLGDELDPATDAWLFTWVEGHRAVLARGKGRTTALQDGLLLAA", "function": "CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.", "AFDB_id": "AF-D3RW30-F1-model_v4" }, { "swissprot_id": "B4N8G6", "sequence": "MAAYAAFKHVELYNVGKAKKRVLRPPGGGSSDIFGADMPATPRTVKNRMISNIFSADKDGAIKNNVRQGAHRFYFIGETPRRGQKSVDSHSRLFGEPSRPITPGKNHMKSSIPFGQNSEAAAAQKLLTNGNTNSTTNGHYNGKSGSVSSASSSVSSSTENLKINSGSRSVFRNMSTAAGADKMNKMDDPDCASLISQGNSGFADPVAQGGDTASIDMPCKSNDVGSLHGDNQSHTESGRYGYSSQSRRTAGTSPLNPYSLDKINSASAAFKEPLGPCSDYIKDPQHVPCIKIHAKDEHRNPITGLGLNGDGVGGLKPKKMKIREGNPVTGEGYKSGGSDSAQTPTMNGANQVINKNRVPPGGYSSGLW", "function": "Binds to all microtubule populations.", "AFDB_id": "AF-B4N8G6-F1-model_v4" }, { "swissprot_id": "P00322", "sequence": "MKIVYWSGTGNTEKMAELIAKGIIESGKDVNTINVSDVNIDELLNEDILILGCSAMGDEVLEESEFEPFIEEISTKISGKKVALFGSYGWGDGKWMRDFEERMNGYGCVVVETPLIVQNEPDEAEQDCIEFGKKIANI", "function": "Low-potential electron donor to a number of redox enzymes.", "AFDB_id": "AF-P00322-F1-model_v4" }, { "swissprot_id": "Q01198", "sequence": "MKDFQDQVAFITGGASGAGFGQAKVFGQAGAKIVVADVRAEAVEKAVAELEGLGITAHGIVLDIMDREAYARAADEVEAVFGQAPTLLSNTAGVNSFGPIEKTTYDDFDWIIGVNLNGVINGMVTFVPRMIASGRPGHIVTVSSLGGFMGSALAGPYSAAKAASINLMEGYRQGLEKYGIGVSVCTPANIKSNIAEASRLRPAKYGTSGYVENEESIASLHSIHQHGLEPEKLAEAIKKGVEDNALYIIPYPEVREGLEKHFQAIIDSVAPMESDPEGARQRVEALMAWGRDRTRVFAEGDKKGA", "function": "Catalyzes the C alpha dehydrogenation of arylglycerol-beta-aryl ether (C alpha alcohol type) (compound IV).", "AFDB_id": "AF-Q01198-F1-model_v4" }, { "swissprot_id": "A2FJ32", "sequence": "MAQIIDENAKVCETLEGYLDSIGITTAGLNYHTLSIIGPQSSGKSTLLNNLFHTTFETMNDQIGRQQTTKGIHAAFNNQNVLIFDIEGSDSRERGDADALFERKAALFGLALSEVVMVNMWEKDIGRYNASSIPLLRTVFEVNLQLFSSSQEAKCHLLFVIRDSTHPGEIIENQVRRDLDMIWKDVILPQNLQGKKFDDFFVFHFFQLPHLKLEPEKFKEQAAKLASMFTNKDEPGFFFAQPMGKLIPGDGLAQYIHSVWDAISENRELNLPSQRKTLSNFRCEEFANQAYKEFETNATEQIVSKIDAKPFTEFKEIGQKLFETAIHNYNQQANKYVRDIANEKRQSLQERISSFLAPSFQRNCTIFKESAEKKFTEYIEKLPTELEESNEWEQNANKKLEETIKSIDEFVKSTMIPEFKWQFDVSDIEDNLHTLITNKLDTAISEMEQRVFERRNIEYKERINAILDSAEPNMWERLRSEMRNEITQTTSEINNILKKNTVDRHPSPKIANMYYRSTDSQITSASQFIQQKMIIRFEEKFLQDEEHKSRVWKPDDDISAIFESARENGLHILNMFTNSQLREPGTPVPLNDILTRQILTQIRREQILTEFNDTIEKSYISAVQIRESLIVRNTVPLWMWIVIAIGGYQQLVSVVEHPWKTLFLLAAIGLVYWLWSNQKLDKVIKVVKNYITRVLCIIVKLLQSTTQEMEVAPSILQASKKSAANDMELIKKGLDDKKIEDEKTLETADTLDTMTTEVSESNSTSASTNSPSKSEDSKEPAPAPKPRHRKRVSTSNNPYATLQPNRINQAELLKMKEMIQKRQAEKH", "function": "Probable GTP-binding protein that may be involved in cell development.", "AFDB_id": "AF-A2FJ32-F1-model_v4" }, { "swissprot_id": "O25093", "sequence": "MRAIAIVLARSSSKRIKNKNIIDFFNKPMLAYPIEVALNSKLFEKVFISSDSMEYVNLAKNYGASFLNLRPKILADDRATTLEVMAYHMEELELKDEDIACCLYGASALLQEKHLKNAFETLNKNQNTDYVFTCSPFSASPYRSFSLENGVQMAFKEHSNTRTQDLKTLYHDAGLLYMGKAQAFKEMRPIFSQNSIALELSPLEVQDIAHFRRFRISQAQIQPFEKRMPVKILCDCFLTSGLGHVRRCEKILSFIEKLGVEASLYLHKQNNISAFLEGVGGNDFLITDSYCLNSKDFYLLKEKAKSLMVIEDTEHAKGFYPKNTKILNFTLNALKHYHHLSKDYQYYLGVGFYPVDARFIYDRPINTENKEVLITLGGSEQKTLKEIVKILENKNVNLHIISPYTPKNPPKNTHYYSPLNPLEFSSLMKSCACAISAAGQTLYELALSQTPSLILPIASNQIIQSKEFESLGIFKQTSLKTLAKDFENLQIQKNQAWAKNLVFGDKLEGALREFLEI", "function": "Catalyzes the fourth and sixth steps in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. The C-terminus mediates the fourth step of the pathway and catalyzes the removal of UDP from C-1 of UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose forming 2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose. The N-terminal part mediates the last step of the pathway by mediating activation of pseudaminic acid with CMP by forming CMP-pseudaminic acid.", "AFDB_id": "AF-O25093-F1-model_v4" }, { "swissprot_id": "Q7RTX7", "sequence": "MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQVLINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPLAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNRRSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSSSQILLKKHKSSH", "function": "Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.", "AFDB_id": "AF-Q7RTX7-F1-model_v4" }, { "swissprot_id": "P69974", "sequence": "MMENYITSFQLRFCPAAYLHLEQLPSLWRSILPYLPQWRDSAHLNAALLDEFSLDTDYEEPHGLGALPLQPQSQLELLLCRLGLVLHGEAIRRCVLASPLQQLLTLVNQETLRQIIVQHELLIGPWPTHWQRPLPTEIESRTMIQSGLAFWLAAMEPQPQAWCKRLSLRLPLATPSEPWLVAESQRPLAQTLCHKLVKQVTPTCSHLFK", "function": "Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.", "AFDB_id": "AF-P69974-F1-model_v4" }, { "swissprot_id": "P21331", "sequence": "MNYGNSSTRSLPSDRSAKLEEMRKIAGADPATIRSQIIASGASTSNQAASLLANSAFNYPSVTTSSDTSFTCTVTTSQASCASTSTYTVAARVGPNICSTTPVGNNSVSDTMAQMAGKAARKGKCSFQAPGLSSSKKRKVVVNACQTIRKVKMQATDLRKATPKVATASATATTMSNNRFAALALEADNVMEQDLAENCSNGEEDVPVVNMNRQSTNGPSKPPAICVPNVDNPHSLEQALNSCVGDNSYSIRTSKFGVSRIYTINADAFRAVVKHLTSLNCQFWHHQLREDKPYTVAVKGMHANVPKAQIEHAFADHGFEALNIYCPRKADWRNAQVSEDDDEATVNFKTRQNMFFVNLKQGPKIAEALKITQLGRYRVTVERAPRRREVLQCLRCHIFGHSKNYCVRDPICAKCAGSHMTGSLLCTSDICMCVNCGGDHASTDKDCPVRIEKLRKMKPSPRLPVPDNATNNKHNRASSARGFIPAEAVRGNMSYADIVRPKGSQFRATATINSQHESNPLHDLGSGNKFLTLEKSIREINGRMDQLFKLVQETVEANKAFRELVQVLISRMPK", "function": "Strongly basic protein that binds directly to retroviral RNA and may be involved in its packaging and in the reverse transcription process.", "AFDB_id": "AF-P21331-F1-model_v4" }, { "swissprot_id": "O34853", "sequence": "MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASLCHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVLPIEEEGEG", "function": "Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity.", "AFDB_id": "AF-O34853-F1-model_v4" }, { "swissprot_id": "O67386", "sequence": "MIKKVAAKPLSWLERIFFIDFIKGLRITLKNALRKTITTHYPYEKITPPKRFRGYFAHKVVDGTEPQPAFQEWVNRYNILVEYGKSRCVVCLRCKRACPVPQLFEIEGKKLPNGKRVVSVFNMNMLLCTYCGFCVDACPVDCLYQTDIHENASYTRKDAVLTLEILEQIGRDWQRRREREPDRIWIDDEQRMKLWGENNVKLPKPEEV", "function": "NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-O67386-F1-model_v4" }, { "swissprot_id": "Q12349", "sequence": "MFPIASRRILLNASVLPLRLCNRNFTTTRISYNVIQDLYLRELKDTKLAPSTLQDAEGNVKPWNPPQKPNLPELELQGPEALKAYTEQNVETAHVAKESEEGESEPIEEDWLVLDDAEETKESH", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.", "AFDB_id": "AF-Q12349-F1-model_v4" }, { "swissprot_id": "P38291", "sequence": "MALKKNTHNKSTKRVTKHPSLKTLTHKQIHTTIFVKSTTPYVSALKRINKFLDSVHKQGSSYVAVLGMGKAVEKTLALGCHFQDQKNKKIEVYTKTIEVLDEVITEGQADIDMESDVEDDDKETQLKKRAVSGVELRIYV", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.", "AFDB_id": "AF-P38291-F1-model_v4" }, { "swissprot_id": "Q94C95", "sequence": "MESARLVGDYALGPRIGSGSFAVVWLAKHRSSGLEVAVKEIDKKLLSPKVRDNLLKEISILSTIDHPNIIRFYEAIETGDRIFLVLEYCSGGDLAGYINRHGKVPEAVAKHFMRQLALGLQVLQEKHFIHRDLKPQNLLLSSKEVTPLLKIGDFGFARSLTPESMAETFCGSPLYMAPEIIRNQKYDAKADLWSAGAILFQLVTGKPPFDGNNHIQLFHNIVRDTELKFPEDTRNEIHPDCVDLCRSLLRRNPIERLTFREFFNHMFLREPRQIPDVEHSGFSTCTGKSLLPSAQPSTSTNRFKSSAENVHKHGSSSSASNSQISMPHTSFEKTRKDTEGQCSSNQSGVVDSLELIEREYVLVNRPSASLEGSSDCFDTSLQDSGFPNILPRNEKVSSSSLEAQKPLSDVSGPRPASVSYLLTEVQRLTIVHPPTKLQLLHQYAQALTELASEMGNTGQVKESFAVTLVVLAVWRKALEICDSWMMSVGENEVNPDPTTAPETSIPDLNSPAPAKTWVTQEFVTALNQAENLSTQLNETSAATHMPDAMETIYERALAYGKSGGAEEYLSNKESAATLYKKAILLLSFIIEEAVTLSLNPSFSLTPDDKKRILYYISNLQHRRSHL", "function": "Serine/threonine protein kinase involved in autophagy in a nutritional condition-dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation. Connects autophagy to plant nutritional status.", "AFDB_id": "AF-Q94C95-F1-model_v4" }, { "swissprot_id": "P13742", "sequence": "MEANPGELERFGKAIRKIWLYETIMLGAEKIAKGNLSEESTSTSESEIPNTSSQQDVISSSEHVSDSLKFWEVLNFLEVSWVPHSGEDGVQHKLSQYVEKDPSTFEELKKRRLAAKNDVYGYVRQIMYSKGQVRIYRGVRCKPNGVLKVSLFYGPCKWVTSMWVTLVPITLRENGSLEDIEFTFNCSLNLKSSKAISAGM", "function": "Plasmid partition require REP1, REP2, and a cis-acting DNA sequence (known as STB).", "AFDB_id": "AF-P13742-F1-model_v4" }, { "swissprot_id": "B3DXP7", "sequence": "MVQDIKRAEIALDFKNKPVFFLVGSTGIGKTAIAHRIADEIGLSLLSIDSMQVYRKLDIGTAKPSLSERIRYRYGGIDLVDWKDSFNAFLFVQQACHYLAKEWENRRGVLAVGGCGLYFRAMTRGLCNAPPANLQLRTELEKMDRITLLERLTRIDPSAVAWVDCSNPRRIIRAIEVKETSGISLIEWQKKTTLPLVTPFLAFWIDRPQPEAEIRLRRRIKKMFERGWEEETLMLIEEGGMEAVEKCKAIGYKLIGQFLLQKRKNREELEEAIYRQQHGYAKRQKTWFKKEPSLCYYLLKNPEEEYRFIKSCIEKIAFFIRRNHQDFLY", "function": "Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).", "AFDB_id": "AF-B3DXP7-F1-model_v4" }, { "swissprot_id": "O74964", "sequence": "MSSKIRPSADDKKLQRVLYFFLERVRAAKDVSGQLLSPLIDNASVDTASVSPSSNGRPTTLKSIQSKIDEFQYHDFSEFVSDLAYLFINVKALYEGTQTYSFVQALEEFCIQQLRTFQQQGYIPVITWPNTDSPSATTSSPISRNPEYSVSPPNGSKFVKNEDEAYDSDLYVEEEDSDVKGRSMVGRDGRYKSEDLKRRKLQPSSKPLSSLEARAKVIMRQVRRYRDGSGRQLFAPFERLPDPRMFPEYYQAIEQPMALEVIQKKLSKHRYETIEQFVDDFNLMFDNAKSFNDPSSQVYRDADFLKNYLADVLRLEAGKLDSEFFNYETDSRASPQLPKNDIQPAVSIDGTLLNVGDWVLIRNPADSSKPIVSQIYRIWKSDDDINYVTVCWYLRPEQTVHRADAVFYENEVFKTSLYRDHPVSEIVGRCFVMYITRYIRGRPKGIRSTPVFVCESRYNDDTKQFSKIKSWKACMPQEVSGSEYEMILFDRPITLTKVASPLLHLLASKSQGLPSPATTDSNTHMLPSQGSLLPPSSISETKSFSTKASTPLSTDDIATPLSSAPNPPSVMPTYARKTSSHSERSSHSSYHNSSHVPTAAFNSPIMRTSTKSTSPIPARPFYAQSGSLQSLNTTQHSHQISGGHSGRMNVPYAKLSYTSHNGRHGGSNGNISGAKTPMTNYTINSMPSLPVFPPAFIVPGTHQKLDESSPVPGIDDVTVINTETAKMLDKDEHQNVLWYTVPPLDPIPLENRNGSLTHSVEYVLYKKSKGSQVITEKARSNELSREAKFENLVASLSDALIPP", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.", "AFDB_id": "AF-O74964-F1-model_v4" }, { "swissprot_id": "A9I4S5", "sequence": "MEFEHRPVLLAPTVDALLLADFAGKGAARSGRQDGAQADARAQRGVFVDGTFGRGGHSRELLRRLGPEARLVVFDKDPQAIAVANELAAGDARVTVVHGGFAAMREELAARGIESIDGVMLDLGVSSPQLDDAGRGFSFMREGPLDMRMDTTRGPTVADWLAQASVDEMREVIADYGEERFAFQVAKAIAARRATRPLRTTLELAECVASAVRTREKGQHPATRTFQALRIYINRELEELSRALASALELLAPGGRLAVISFHSLEDRMVKQCIAAAARPAVAHARLPLRESELPQPLYRSLGRVQADDEEIAGNARARSAVLRVAERTTEPLGADGAAAFVPAMRVPGEAAPARRGARRRPH", "function": "Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.", "AFDB_id": "AF-A9I4S5-F1-model_v4" }, { "swissprot_id": "P15939", "sequence": "MYRISSFKRSAPQLTLGSIALAAVTLTCVYFQAHFAAAAFAYLLVVLLFSLMGSFIASSALCIVAIAALAYYFAPPAFSLRIDDPRDVPVVVAFLIVSVVGTYLIGKLRQEREAARVAAAKLQRSASDLEDREKRWRAIFEHNPAMYFMVDEAGIVLNVNTLGATQLGFACAELLGQSVLDVFLEEDRAFVRKCIQTCLEDVGQSRTWDVRKVRKDGSVLWVRENAKAMLWAGDRPVILMACEDITERKQTELALQRSEAHLAHAQELSHTGSFSWNASTGEAFWSKETFRIFQIDLQTTPAPQLVIERTHPDDRASVKEIIDEAMRDLRDFEHEYRLLLPDGSVKHIHAQARVTRTASGEIEFVGAATDITAARRAEQQLRRSEAYLAEAQHLTHTGSWSWDVHTRDFVYRSAEVDRLFGFNPQEPVSLETIRSRIHPEDLPGLQEVQRQAIDQEHERFEYDFRVILPDGGIRRIHSVAHVVVGSDGNVSELIGTHMDVTEQHAARERLENTLVALRESEQRFRDYAETASDWLWETGPDHRVTHLSEHTSAAGILATGLTGLLRWDIACDMEEEPEKWRQHRATLQAHLPFRDLIYRTVNRMGSPIYVRTSGKPFFDGNGNFLGYRGVSTDITATIRADQAEQELRKAQAELAHVTRVTTLGEMTTSIAHEITQPLAAILSNADACLGWMARDVPNLAAARSSVEWIIEDAIRASEVIRSIRALAKKGEIEMVPLDINQVVRDVSALVTRELVSHQVTLRSELASALPRVLGDRIQLQQVIINLVMNGIEAMDAVTDRPRELLIQSSTDDLGYVQLSVTDCGVGIAENDADRVLDPFFTTKSSGLGMGLSICRSIVEVHGGRISVVQKNGPGATFQFALPLHKEAIS", "function": "Member of the two-component regulatory system NodV/NodW probably involved in the regulation of the transcription of genes involved in the nodulation process. NodV may function as a membrane-associated protein kinase that phosphorylates NodW in response to environmental signals.", "AFDB_id": "AF-P15939-F1-model_v4" }, { "swissprot_id": "P36235", "sequence": "SDDKCQGRPMYGCREDDDSVFGWTYDSNHGQCWKGSYCKHRRQPSNYFASQQECRNTCGA", "function": "Tick salivary platelet aggregation inhibitor that plays an important part in the anti-hemostatic strategy of ticks. Inhibits fibrinogen interaction with platelets. Acts by binding (in a divalent metal ion dependent manner) to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP (IC(50)=99-104 nM), thrombin, collagen (IC(50)=64 nM) platelet-activating factor and collagen. Interacts to unstimulated platelets (Kd=42.5 nM) and to ADP-stimulated platelets (Kd=39.4 nM). In contrast to many disintegrins which only interact with the beta-3 subunit, interacts with the two subunits (alpha-IIb and beta-3). Under flow conditions, reduces and delays platelet adhesion, aggregation, and fibrin formation.", "AFDB_id": "AF-P36235-F1-model_v4" }, { "swissprot_id": "Q8Y588", "sequence": "MKIKSFLGKSLTLVVLGVFLFSGWKIGMELYENKHNQTILDDAKAVYTKDAATTNVNGEVRDELRDLQKLNKDMVGWLTIIDTEIDYPILQSKDNDYYLHHNYKNEKARAGSIFKDYRNTNEFLDKNTIIYGHNMKDGSMFADLRKYLDKDFLVAHPTFSYESGLTNYEVEIFAVYETTTDFYYIETEFPETTDFEDYLQKVKQQSVYTSNVKVSGKDRIITLSTCDTEKDYEKGRMVIQGKLVTK", "function": "Transpeptidase that anchors surface proteins to the cell wall (Probable). Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable). Catalyzes a cell wall sorting reaction in which a surface protein with the consensus sorting signal NP(Q/K)(T/S)(N/G/S)(D/A) is cleaved between the fourth and fifth residues, and the fourth position is linked to the cell wall (Probable). This is not the major sortase in Listeria, it seems to anchor only 2 proteins, Hbp2 (SvpA) and Hbp1.", "AFDB_id": "AF-Q8Y588-F1-model_v4" }, { "swissprot_id": "Q9BVC3", "sequence": "MKRTRDEVDATLQIAKLNAAELLPAVHCLGFGPGASGAAAGDFCLLELEPTLCQQLEDGHSLVIRGDKDEQAVLCSKDKTYDLKIADTSNMLLFIPGCKTPDQLKKEDSHCNIIHTEIFGFSNNYWELRRRRPKLKKLKKLLMENPYEGPDSQKEKDSNSSKYTTEDLLDQIQASEEEIMTQLQVLNACKIGGYWRILEFDYEMKLLNHVTQLVDSESWSFGKVPLNTCLQELGPLEPEEMIEHCLKCYGKKYVDEGEVYFELDADKICRAAARMLLQNAVKFNLAEFQEVWQQSVPEGMVTSLDQLKGLALVDRHSRPEIIFLLKVDDLPEDNQERFNSLFSLREKWTEEDIAPYIQDLCGEKQTIGALLTKYSHSSMQNGVKVYNSRRPIS", "function": "Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.", "AFDB_id": "AF-Q9BVC3-F1-model_v4" }, { "swissprot_id": "Q3MV14", "sequence": "MSKRPPPDPVAVLRGHRHSVMDVSFHPSKSLLFTGSADGELRIWDTIQHRAVSSAWAHSRANGVLAVAASPWLGEDKIISQGRDGTVKCWDIEDGGLSRDPLLILETCAYHFCKFSLVKKPKNSLQEAESHSRGCDEQDGGDTCNVQIADDSERSEEDSGLLQDKDHAEGTTFVAVVGEQPTEVEIWDLNTGDKIIQLPQSSPDESPNASTKGRGMCMAVQLFCPPESQGFLHVLAGYEDGSILLWDIRNAKIPLTSVKFHSEPVLSLSVASSCDGGISGGADDKIVMYNLNHSTGSCTIRKEITLERPGVSGTSIRVDGKIAATAGWDHRIRVYNYRKGNALAILKYHRATCNAVSYSPDCELMASASEDATVALWKLYPPHKSL", "function": "Involved in the formation of X-, Y-shaped and twinned plasmodesmata (PD), thus modelating PD size exclusion limit and regulating cell-to-cell transport. Cell cycle checkpoint regulator that monitors and responds to DNA damage such as DNA cross-links, and triggers the halt of the cell cycle progression in the presence of DNA cross-linking agents. Mediates the active process of aluminum- (Al) dependent root growth inhibition and thus is required for response to Al toxicity. Required for both early and late phases of embryo development as well as during seedling growth. Essential for signal transduction and development of both male and female organs.", "AFDB_id": "AF-Q3MV14-F1-model_v4" }, { "swissprot_id": "Q54II8", "sequence": "MNPLTLVRETTAWVSGLSKHVKINNEALDKECEDFLNKHKIKAHKEIWADNWFHYCDIDIENKESTFTELTAKYILVLDTLNFCFWPDSEFEYHHLARGLKNALIANPKCFDADQLIKVTSETIHQWFGKDLPNTSERVRLIREVGTVLIEYFNGSIKEMILSANNKASVLVDLVTKYFWGFRDSAIYKGKQVFFYKRAQIFVGDLWGAYQGRGLGKFDDIKQLTMFADYRVPQILEELKVIEYSPELKEMIKNKVEIPVGSEMELEIRAVTVHVVEKMRDYFNKGHCELLALEIDWMLWGRGEAMLDKLPPHHRTLTIFY", "function": "Involved in salvaging queuosine.", "AFDB_id": "AF-Q54II8-F1-model_v4" }, { "swissprot_id": "Q08974", "sequence": "MTAHANERISDVSPSARGSSSESKYDKLCRVLFFIAITKSSFTPEHILYKHSIFTDKPILADIVTFMYAAFVSIGWFLIWGERAYRTQEMGQPPMYSNINYHLLSFKKRHPKKFTCALWLVFFLAYTVLTVLIWLVQLIFRKGNVFQMLLQLIILDIAIALVNVAIAFTFEIYLSQKAAIEIRDEGLNNLDTA", "function": "May be required for cell cycle progression.", "AFDB_id": "AF-Q08974-F1-model_v4" }, { "swissprot_id": "Q8BMK0", "sequence": "MAMQEKYPNDRSHATSPGSNVIQKGSSLGTEWQTPVISETFRSRFSRCSSIADSGDTAIGTSCSDIAEDFCSSSGSPSFQPIKSHITIPTAHVMPSTLGASPAKPNSAPSGPSSAKLPLSGLTEGVGMTRNGDFGAVKRSPGLARDFMYLPSAAGENGSQQSWFPAVGHEREGEMRKFDVPSMESTLNQPAMLETLYSDPHYRAHFPNPRPDTNKDVYKVLPESKKAPGSGAVFERNGPHASSSGVLPLGLQPAPGLSKSLSSQVWQPSPDPWHPGEQSCELSTCRQQLELIRLQMEQMQLQNGAMCHHPAAFAPLLPTLEPAQWLSILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSKEKMELEKKLSASEVEIQLIRESLKVTLQKHSEEGKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQTEQLKDAELKNTELQERVAELETLLEDTQATCREKEVQLESLRQREADLSSARHSFQDKQSVEEANGENLRVDMESQQKECDSLRKMVERQQLKMEQLHSQVQSQKQELAQEEGINQALREEAQRRETALQQMRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSSSSPDSAQLACELHQELASCLQDLQAVCSIVTQRAQGHNPNLSLLLGIHSTQHPGTQLDLQKPDVIRRKLEEVQQLRHDIEDLRTSLSDRYAQDMGENCATQ", "function": "Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity.", "AFDB_id": "AF-Q8BMK0-F1-model_v4" }, { "swissprot_id": "Q9UBL6", "sequence": "MSAGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQPAQKWLLQVVMRVSVDVLGPAGHCAKHFLCCTESSHLARTGPSFLLRYDDLCLPWATAGAVRWWTCRGGHTQGWQIVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRGLPPRSLGVPAGEASPGCTP", "function": "Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.", "AFDB_id": "AF-Q9UBL6-F1-model_v4" }, { "swissprot_id": "E1BDF2", "sequence": "MAPPAGGTAAGSDPGSAAVLLAVHVAVRPLGAGLDVAAQPRRLQLSADPERPGRFRLEMLGAGPGAVILEWPLESVSYTVRGPCQHELQPPPGGPGTLSLHFANPQEAQRWAALVRDATVEGQNGSDSLPPALGPETRPVSPPSPLEVPTPKAPKPKVDLPWSPGDLMEKEELAGRLTRAVEGGDEKGAAQAAAILAQRHVALRVQLQEAYFPPGPIRLQVTVEDAASSAHVSLQVHPHCTIRALQEQVFSEFGFPPAVQRWVIGRCLCVPEHSLAFYGVQRDGDPAFLYLLSAPREAPGRSPQRPQKVDGELGRLFPQSLGLPPTPQPTSSSLPSPLQPGWPCPSCTFINAPSRPGCEMCSTQRPCAWDPLPTASIQQLPKVTRREDGPSLPGPRSLDPLLNLSGNLC", "function": "Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.", "AFDB_id": "AF-E1BDF2-F1-model_v4" }, { "swissprot_id": "A6X0F8", "sequence": "MKNAPAVSFSAMPSADAERPILVFDSGIGGLTVLREARVLMPDRRFVYVADDAGFPYGGWEEDALRERIVELFGKLIAAYDPEIAVIACNTASTLVLDDLRQAYPSVPFVGTVPAIKPAAERTSSGLVSVLATPGTVRRAYTRDLIQSFATQCHVRLVGADQLATVAEAHIRGERIDEALVVEQIAPCFIEQDGNRTDIVVLACTHYPFLANVFRRLAPWPVDWLDPAEAIARRTVSLLKPRRADEELHHHNDLAVVTSRNPDYAIRRLMQGFGLHFA", "function": "Provides the (R)-glutamate required for cell wall biosynthesis.", "AFDB_id": "AF-A6X0F8-F1-model_v4" }, { "swissprot_id": "Q9UTR8", "sequence": "MSRSINLDELRKKALESKKKNEEDESNDSDKEDGEISEDDPVIDQSNSVPPMKVPTFPEQIPQLPPFDRFPGTNANFFPFGAPFMLPPALMFGPNTVPFFPQTASSNKTFSKRKRSSENSFNNRNKAKSSETSDSSNTSQSFKENRALKDTATSRPLALSSDTSYQKSEKAKSEKSPFLSTSKNSDANYSKTTNQKEAEKAVSQLFEVGVRFNDFIAEGIEPSVVHTLFLKLGLDSSSASSQGSLTLSADKAARSAKLRKIDSNLSDTHILPGDNGTPTVLPERKNLISLPLLKQDDWLSSSKPFGSSTPNVVIEFDSDDDGDDFSNSKIEQSNLEKPPSNSENGLTMSRSDYLALLRNKEEEIRRMTKLILRLESNKKPYRSPTSAADMKLPSVPVAAVDNKSKTHLDTFEKVVDLSSKADFVEAGPSISSSGASSSAATTNSDTTEQILEAPWLRKTEQIAVVHEEHPAQIKKSEIDILNNLIEKEEGELTKYQTLVKSKTEILTQLYTRKKQLLEQQGKGNVACLPKESDLSMDSITEVSAQADENSSQILSSKTSNAPNGTTETDFEDKVPLVDYISPFYRFKSYRFNQQFVERVPLKYRSLTYSNKIEPMKVFCKYETTGGVCNDDHCEASHFRDIKMTDDEIIQDLSRYIEGNDEIEKESYKSGLDIVMKNTDENTDFVDVATRIVEYHNLWKSERMTIPVAKVSI", "function": "Promotes the exosome-mediated degradation of mRNAs containing a DSR (determinant of selective removal) signal sequence from mitotic cells.", "AFDB_id": "AF-Q9UTR8-F1-model_v4" }, { "swissprot_id": "P43548", "sequence": "MAVLNLKRETVDIEETAKKDIKPYFASNVEAVDIDEDPDVSRYDPQTGVKRALKNRHISLLALGGVIGPGCLVGAGNALNKGGPLALLLGFSIIGIIAFSVMESIGEMITLYPSGGGFTTLARRFHSDALPAVCGYAYVVVFFAVLANEYNTLSSILQFWGPQVPLYGYILIFWFAFEIFQLVGVGLFGETEYWLAWLKIVGLVAYYIFSIVYISGDIRNRPAFGFHYWNSPGALSHGFKGIAIVFVFCSTFYSGTESVALAATESKNPGKAVPLAVRQTLWRILVVYIGIAVFYGATVPFDDPNLSASTKVLKSPIAIAISRAGWAGGAHLVNAFILITCISAINGSLYIGSRTLTHLAHEGLAPKILAWTDRRGVPIPAITVFNALGLISLMNVSVGAANAYSYIVNLSGVGVFIVWGVISYTHLRIRKAWVAQGRSIEELPYEALFYPWTPVLSLAANIFLALIQGWSYFVPFDAGNFVDAYILLPVGILLYIGICVFKSNHFRTVDLRSINLDEGRRKDMEADLSDQESSLASSETMKDYKSATFFRYLSNIFT", "function": "General amino acid permease with broad substrate specificity.", "AFDB_id": "AF-P43548-F1-model_v4" }, { "swissprot_id": "P45135", "sequence": "MATYFSDNLTADQQNQVQQIIQQFQHPTLQKDLIVLNTLKKVEKGGDTLRIELQLPFAWNSGAEQLKQAVSDALLKATDCKLIKWAVAYQIATLKRANNQPAVKGVKNIIAVSSGKGGVGKSSVSVNLALALQAQGARVGILDADIYGPSIPHMLGAADQRPTSPDNQHITPIKAHGLSANSIGFLMNEDSATIWRGPMASSALSQLLNETLWDSLDYLVIDMPPGTGDIQLTLSQQIPVTGAVVVTTPQDIALLDAVKGISMFERVSVPVLGIVENMSMHICSECGHHEAIFGTGGAEKMAEKYNVKVLAQLPLHIRIREDLDAGNPTVVRVPENEISQAFLQLAEKVSTELYWQGSVIPSEILFKEVK", "function": "Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.", "AFDB_id": "AF-P45135-F1-model_v4" }, { "swissprot_id": "E9R9Y3", "sequence": "MGKAALQDPHGGIWYFAYGSNLRLSVLENRGIKALDIKAVIVPSHYLTFDIFGIPYAEPSFASVAPFAREKKTTLRLGDSPASRDVPPVQGLAYLLNPRDYRQLVISEGGGVAYDEVEVHASILDKDGKPDPGATLIARTLQAKYPWRPNGAPSARYLGLISTGCKQNEPLTAYSDYIDSLPAYEPPTSLHAKVGGLLFLMFWRPPLRLLIRLIRVNTDQDGHCPQWLGWIILTLYGLMWSYHDNIHSKIWGRGDGRKLHFEETPAKEVPVRH", "function": "Gamma-glutamyl cyclotransferase-like protein; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp. The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain. The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin. This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties. Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure. GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides. Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA. Gliotoxin contributes to pathogenesis during invasive aspergillosis. In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species.", "AFDB_id": "AF-E9R9Y3-F1-model_v4" }, { "swissprot_id": "P47179", "sequence": "MVNISIVAGIVALATSAAAITATTTLSPYDERVNLIELAVYVSDIRAHIFQYYSFRNHHKTETYPSEIAAAVFDYGDFTTRLTGISGDEVTRMITGVPWYSTRLKPAISSALSKDGIYTAIPTSTSTTTTKSSTSTTPTTTITSTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTSTTPTTSTTPTTSTTSTTSQTSTKSTTPTTSSTSTTPTTSTTPTTSTTSTAPTTSTTSTTSTTSTISTAPTTSTTSSTFSTSSASASSVISTTATTSTTFASLTTPATSTASTDHTTSSVSTTNAFTTSATTTTTSDTYISSSSPSQVTSSAEPTTVSEVTSSVEPTRSSQVTSSAEPTTVSEFTSSVEPTRSSQVTSSAEPTTVSEFTSSVEPTRSSQVTSSAEPTTVSEFTSSVEPTRSSQVTSSAEPTTVSEFTSSVEPTRSSQVTSSAEPTTVSEFTSSVEPIRSSQVTSSAEPTTVSEVTSSVEPIRSSQVTTTEPVSSFGSTFSEITSSAEPLSFSKATTSAESISSNQITISSELIVSSVITSSSEIPSSIEVLTSSGISSSVEPTSLVGPSSDESISSTESLSATSTFTSAVVSSSKAADFFTRSTVSAKSDVSGNSSTQSTTFFATPSTPLAVSSTVVTSSTDSVSPNIPFSEISSSPESSTAITSTSTSFIAERTSSLYLSSSNMSSFTLSTFTVSQSIVSSFSMEPTSSVASFASSSPLLVSSRSNCSDARSSNTISSGLFSTIENVRNATSTFTNLSTDEIVITSCKSSCTNEDSVLTKTQVSTVETTITSCSGGICTTLMSPVTTINAKANTLTTTETSTVETTITTCPGGVCSTLTVPVTTITSEATTTATISCEDNEEDITSTETELLTLETTITSCSGGICTTLMSPVTTINAKANTLTTTETSTVETTITTCSGGVCSTLTVPVTTITSEATTTATISCEDNEEDVASTKTELLTMETTITSCSGGICTTLMSPVSSFNSKATTSNNAESTIPKAIKVSCSAGACTTLTTVDAGISMFTRTGLSITQTTVTNCSGGTCTMLTAPIATATSKVISPIPKASSATSIAHSSASYTVSINTNGAYNFDKDNIFGTAIVAVVALLLL", "function": "Component of the cell wall.", "AFDB_id": "AF-P47179-F1-model_v4" }, { "swissprot_id": "A0A125S9M4", "sequence": "MAEKAGEAGVQTRSRRNRSTSREVSNGVAAPPAKATRSSQLEAVAEQATPSSQQSQKSVRTESSMSLGFNGGSSQGSRATSPTSFSRAQEKEELQNLNDRLAKILNKLNDSEEENRTLKIRLTTVQQETSADLNDQIGKYRDELERARKAVDAITQEKDRELLAKDKALGELNEHKAQFAALRKRLDELEARLKAAEKAARDKDNVLTELKAQLAESETAGKRIQKELADKTKQLDQARNQIEQEVISRTNLENALKTAEEKAKFENNLLESKLQRQSLSVTTVDHHSAQSTSRRSGSDFSASVEDMRSALEDAREEIQENMDRMYGSKLEGLEVLSESQKQTINGLNQALTASRHDMKDLQKENQQLRKKVGEVEKELHQQHQKFDQHKMDCTARIAALSDQSNQASQQYQALLEEYRTTTHNNVEMRTELEMYNKLLSDEEIRLGITSADQYGGVRHGAKKRKLTETFYTTPFGSRSSAGSRSAGHNSTPVTKSQVTRTTVKTSENKSKASGPVRILEVAPGKVVRLENISEAVMQLGHWRIHQHGASGDAAFQFEKDQVIGGQSIISVYSSTEDSQPNNGVTEIIATNAWLADSHLETVLSDGDGNQMATYEVSADSNLDIHNDSVRDSPRSAGKGILGFFGL", "function": "Intermediate filament (IF) protein, component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope.", "AFDB_id": "AF-A0A125S9M4-F1-model_v4" }, { "swissprot_id": "Q5KQL9", "sequence": "METPPPDPVSPPPPAADEGSPGGDDGAEDAGGFSAGLDSLWTALFGSPEELEPMWSPPRGFGVGAEFAAAEVEPEIMDVAGGPWDGAPWRSSGVVAGEGAATALVPPTAAAGFAEFEPAAPIDSYPAGAAAASLGDVPEVSALDSGVDCSPDPPPSSSPPVDFDARGFDPVADSAPAMESPLPPSVASSEANLDGRMLDCTLNSVPSPPLASPYEVGLGAEDPIKDSSPSVAWGTTMDAKDPEVDATCANGTALRRSRRIMKIKSAASSMPLNQNGDSSRASKRRVADSRKSRSSEGSKLPAFTGPISVNTVDLINGVKVQGLQEIVAVENVSSSYDNNQKAGGLYNQVVVALPAASNSLLKDKGASVLPRRKTRLASKVLVNSDRVSAISPVVNGGPPVQKSDVCIPTKKHKLAVEECLTSLDGVDGGGIVLCNSKLKSAKSRVVSKTPQGRGRRSPQPPKTQRARTLSVKYLEKLKRAENNNNNGSMSKSPRVPMIPENNGSMSKSPRVPIIPELSTKHELVLDKHMVDSVMLETDDGSCFFVGDAVPDDEARKQWPHRYEINDQIMKKDKRTSSQTFANAGKAVLDVKCHYLQAKVSRYTFCIGECAFVKGPEGKPNYIGRLLEFFETKTGECYFRVQWFFTAEDTVIGEQAQSHDPRRLFYSDLTDDNLLDCIVSKVTIVQVPPSVDGKSKSVPSSDYYYDMKYSIDYSTFSTIEMEDTDDLMQSCYTSRINDKMKKIDVNKKHKSPVLEKMELSLLDLYCGCGGMSTGLCLGARGGGVNLSARWAIDDDEIACESFRNNHPETRVRNETTDDFLELLKEWEKLCKTYVKHSRTKACVDSTTESNNETPDCSTVPPEEFEVWKLVDICFGDPNKVSKHGLYFKVRWKGYGPHHDTWEPVEGLRNCKEAIRDFVIEGHRQRILPRPGDVDVVCGGPPCQGISGYNRNREFEAPFKCEKNKQIIVFMDVVQFLKPKYVYMENVLDILKFADATLARYALSRLVAMHYQARLGIMAAGCYGLPQFRMRVFLLGCHSKEKLPPFPLPTHEAIVKNGCPLAFERNLVGWPNDTPMQLARPIVLEDILSDLPEVANGESRDEMLYVKGPQTEFQRYIRSFNVEVHGPRAHVTKDSKSSKLYDHRPLVLDNDNYQRILQIPKRKGANFRDLSGVIVGPDNVARLDPTKERVLLPSGRPLVLDCILAYENGKSLRPFGRVWWDEVVGTVLTVPNARMQALIHPAQDRLLTIRESARLQGFPDNYRFRGTVKDRYRQIGNAVAVPVGRALGYALAMAYLKKSGDDPLMLLPPNFAFSHDLRGFA", "function": "Involved in CpXpG DNA methylation.", "AFDB_id": "AF-Q5KQL9-F1-model_v4" }, { "swissprot_id": "P08235", "sequence": "METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAVVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK", "function": "Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.", "AFDB_id": "AF-P08235-F1-model_v4" }, { "swissprot_id": "Q27934", "sequence": "MSTNQQQQANPSAAVAAPAASSEYLKRTCLICGCHTNQTINIYEPRSGPNIVQLIQAKFKFQPLNEDKFLCFSCNNWLINWHSLQAVNSNEAESQSQSPSHMGNSVLQQERTKLRPVAMVRPTVRVQPQSQPQLQPQVPINPTPAPIVYSKRRASRRSASVSRMSRVLRQCCVESLRRSPKKRNQQSVFVCLRPQGQKRSNAICKVECVAPRRKPVERLVKDVAATATPTPVLNTQSTPTYQRFPQPSVDGKVVAMFRRLGTTLSREEPAAYSAESNPACSKLPQIMSPLKEAPRWTRDLDDDEILLEFDTAISEVLPTARYQVTHEENKENQQAQEMELELEEEEEVDGRAELEVVQEAEAPLEPQSHHKQGNSHQNSHQASIQLAGLRLPMGLSISLV", "function": "Essential adapter component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, embryonic nervous system, external sensory organ development and specification of particular muscles. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Acts downstream of Notch signaling to specify the fate of the SOP (sensory organ precursor) cells and their progeny, probably via the sina-mediated proteasomal degradation of ttk. Its restricted pattern of expression, upon Notch and Ras signaling pathways, suggests that it acts as a key determinant in E3 complexes to trigger protein proteolysis in appropriate cells.", "AFDB_id": "AF-Q27934-F1-model_v4" }, { "swissprot_id": "Q9V931", "sequence": "MLKLWLICILTVSVVSIQSLSLLEETNYVSDCLASNNISQAEFQELIDRNSSEEDDLENTDRRYKCFIHCLAEKGNLLDTNGYLDVDKIDQIEPVSDELREILYDCKKIYDEEEDHCEYAFKMVTCLTESFEQSDEVTEAGKNTNKLNE", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.", "AFDB_id": "AF-Q9V931-F1-model_v4" }, { "swissprot_id": "P42592", "sequence": "MKIKTILTPVTCALLISFSAHAANADNYKNVINRTGAPQYMKDYDYDDHQRFNPFFDLGAWHGHLLPDGPNTMGGFPGVALLTEEYINFMASNFDRLTVWQDGKKVDFTLEAYSIPGALVQKLTAKDVQVEMTLRFATPRTSLLETKITSNKPLDLVWDGELLEKLEAKEGKPLSDKTIAGEYPDYQRKISATRDGLKVTFGKVRATWDLLTSGESEYQVHKSLPVQTEINGNRFTSKAHINGSTTLYTTYSHLLTAQEVSKEQMQIRDILARPAFYLTASQQRWEEYLKKGLTNPDATPEQTRVAVKAIETLNGNWRSPGGAVKFNTVTPSVTGRWFSGNQTWPWDTWKQAFAMAHFNPDIAKENIRAVFSWQIQPGDSVRPQDVGFVPDLIAWNLSPERGGDGGNWNERNTKPSLAAWSVMEVYNVTQDKTWVAEMYPKLVAYHDWWLRNRDHNGNGVPEYGATRDKAHNTESGEMLFTVKKGDKEETQSGLNNYARVVEKGQYDSLEIPAQVAASWESGRDDAAVFGFIDKEQLDKYVANGGKRSDWTVKFAENRSQDGTLLGYSLLQESVDQASYMYSDNHYLAEMATILGKPEEAKRYRQLAQQLADYINTCMFDPTTQFYYDVRIEDKPLANGCAGKPIVERGKGPEGWSPLFNGAATQANADAVVKVMLDPKEFNTFVPLGTAALTNPAFGADIYWRGRVWVDQFWFGLKGMERYGYRDDALKLADTFFRHAKGLTADGPIQENYNPLTGAQQGAPNFSWSAAHLYMLYNDFFRKQ", "function": "Glucoside hydrolase that cleaves the alpha-1,3-glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose.", "AFDB_id": "AF-P42592-F1-model_v4" }, { "swissprot_id": "Q99027", "sequence": "MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQFMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHLKDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISIAYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIFNLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLILTNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILGRMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFRLKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKVIFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINTPRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEKQRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVISMTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLYRIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGIKERVRALDGRLRIETSEGKGFKADIEIEL", "function": "Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates ComA by phosphorylation.", "AFDB_id": "AF-Q99027-F1-model_v4" }, { "swissprot_id": "P53881", "sequence": "MNFHTARISQVGVISRALLSSVSRRWIHVTPISLNNSGGSLFGSITENKPKEGKNRGDEDAGSFSNRLAIASDSSGEAPEVNRDSITIENDKLLQQHIISLQQPEQLASQSLLSPLKREIYEANCKINGGFYKKDTIVKLPNSSERYKLKLTKREIEVLEPSVYAQSYRIKSSMKKATLLLRLLGGLDVMKAISQCHFSNKKIAREVAELLQKGVKDGQKLGLKPEDLYISQIWTGSDGFWRKRVEFKARTRIGIISHPYIHVRCILRTKSVTKRRLAYEAHLKEQKRAPWVQLGDKPIRGVTGGVYKW", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.", "AFDB_id": "AF-P53881-F1-model_v4" }, { "swissprot_id": "Q00684", "sequence": "MRRSVYLDNTIEFLRGRVYLGAYDYTPEDTDELVFFTVEDAIFYNSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANAACMLCCYMILVQAWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTPDFIAFASPQEDHPKGYLATKSSHLNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQNDFREWKYTTRISLKPSEAIGGLYPLISLEEYRLQKKKLKDDKRVAQNNIEGELRDLTMTPPSNGHGALSARNSSQPSTANNGSNSFKSSAVPQTSPGQPRKGQNGSNTIEDINNNRNPTSHANRKVVIESNNSDDESMQDTNGTSNHYPKVSRKKNDISSASSSRMEDNEPSATNINNAADDTILRQLLPKNRRVTSGRRTTSAAGGIRKISGSIKK", "function": "Protein phosphatase which antagonizes mitotic cyclin-dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintained to facilitate completion of cell division in response to minor perturbation of the cell division machinery. Inhibits transcription of ribosomal genes (rDNA) during anaphase and controls segregation of nucleolus by facilitating condensin targeting to rDNA chromatin in anaphase. Dephosphorylates SIC1, a CDC28 inhibitor, and SWI5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of mitotic cyclin degradation, CDH1. Dephosphorylates the microtubule bundling factor ASE1 which is required to define a centered and focused mitotic spindle midzone that can drive continuous spindle elongation. Dephosphorylates the anaphase-promoting complex inhibitor ACM1, leading to its degradation. Facilitates INN1-CYK3 complex formation which promotes cytokinesis through the dephosphorylation of CDC28-phosphosphorylated INN1. Reverts also the inhibitory CDC28 phosphorylation of CHS2 for endoplasmic reticulum export, ensuring that septum formation is contingent upon chromosome separation and exit from mitosis. Additional substrates for CDC14 are the formins BNI1 and BNR1, as well as CDC6, DBP2, DSN1, INCENP, KAR9, MCM3, ORC2, ORC6, SLD2, and SWI6. Activity is inhibited by interaction with NET1 which sequesters it to the nucleolus.", "AFDB_id": "AF-Q00684-F1-model_v4" }, { "swissprot_id": "P32491", "sequence": "MASMFRPPESNRSHQKTPKLTLPVNLVQNAKSTNDGQHLNRSPYSSVNESPYSNNSTSATSTTSSMASNSTLLYNRSSTTTIKNRPVPPPLPPLVLTQKKDGIEYRVAGDSQLSERFSNLHVDITYKELLSSAPISTKLSNIDTTFIKKDLDTPEGEDSYPSTLLSAYDFSSSGSNSAPLSANNIISCSNLIQGKDVDQLEEEAWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWIVGQMKKKVNMERFVKKCWEKEKDGI", "function": "Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involves the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.", "AFDB_id": "AF-P32491-F1-model_v4" }, { "swissprot_id": "Q60992", "sequence": "MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSIAQSKGIRPFPSEETAENDDDVYRSLEELADEHDLGEDIYDCVPCEDEGDDIYEDIIKVEVQQPMKMGMTEDDKRSCCLLEIQETEAKYYRTLEDIEKNYMGPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSMMAGGSTLAKVFLEFKERLLIYGEYCSHMEHAQSTLNQLLASREDFRQKVEECTLRVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSADRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQCSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEVIELLFHKMTDDPMHNKDIKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYLCTRCGVGAHKECLEVIPPCKMSSPADVDAPGAGPGPKMVAVQNYHGNPAPPGKPVLTFQTGDVIELLRGDPDSPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPTGRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWIHITEAKKFESLLELVEYYQCHSLKESFKQLDTTLKFPYKSRERTTSRASSRSPASCASYNFSFLSPQGLSFAPQAPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGVQ", "function": "Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.", "AFDB_id": "AF-Q60992-F1-model_v4" }, { "swissprot_id": "P46375", "sequence": "MNSADTQEPKSFNHTDMWTAFGTTMSGALETDPRAVVVLADIGAHLFKAAAIADPNRVINVGIREQLMMGVAGGLAMCGMRPVVHTVAAFLVERPLEQIKLNFAQQDVGAVLVSWGASYDLSEFAFSHFTPGDITVIDSMPNWTVHVPGHPQEAADLLLESLPGDGRVYLRLSSQVNRYPHAVRGTSFTPIKYGTRGVVLAVGPCLDAVLSATSMLDVTILYAATIRPFDATGLCAAVQAVNRPNVVLVEPYLAGTSAHQVSSSLVSHPHRLLSLGVRREMEDRHYGTPDDHDHIHGLDARSLSNSINSFLG", "function": "The FAS-operon encodes genes involved in cytokinin production and in host plant fasciation (leafy gall).", "AFDB_id": "AF-P46375-F1-model_v4" }, { "swissprot_id": "Q9LSS5", "sequence": "MQTQKARNGSPDVPKKVSPRAARPLKIAALEPESSSSPISATNRTPKDKSPNVLNRRSPRSPVSEKKRPSRITELELLVSQLQEELKKAKDQISVSETSKKQAEQEAEESRKQLQEVSSKLEESQNQFVETSALEEETDKTGSLVFQSVSQECDWEFSATAGERAGLAAVAHEIRQLKLQIEMVASSEAGHVKQAELYNSEVQLLRGNLMDTLFHVENFRNQLKDCEISEAETEALATETLRQLENAKKAVEELKSDGTKAVESYKKMAVELEQSKSRMVWLEALVNKLQNNPADLENHEILLKDYESLRRGESNEMDEEVSSLRCEVERLRAALEASDKKDQEGNVEASSRLRIQAELQSELKIAKSEIDELKARLMDKETELQFISEERDNFSMKLMKNQKEIDVEAELKKLREAIENLKADLMDKETELQIVSDENETLKSDIHKSETDVQDAFLKLGIAMEEADKSSKKAVRVTEQLEATQASNSEMETELRKLKVQSNQWRKAAEAATAMLSAGNNGKFAENYNQTNSPYSEDIDDELTKKKNGNVLKKIGVLWKKPQK", "function": "Acts as a scaffold, mediating interaction of ROPs with different proteins.", "AFDB_id": "AF-Q9LSS5-F1-model_v4" }, { "swissprot_id": "Q7PWT9", "sequence": "MENDKMEIYESLIRWLSELNLSAPHGTVQELSDGAALAQALNQIAPEVFTDSWLSKIKSDVGANWRLKVSNLRKIIEGIYVYYQDELSLNLSEELRPDALKIAEKGDPHELGRLLQLILGCAVNCLEKQKYITQIMELEESLQRNIMAALQDIEYIWQGASPSRNSINTAATSLDVKTLQEDRDTLAQKCHETNKKMLGLIEEKAALQQEIVKLQAIVGRYENPNLIGDDGTSLGPIQLGSSRYNDLRKLVDSLKDELLQAETARDDLKMKSMIQEKEIGELQVKIDELHAATAEIAQLKDEIDILKEANEKLKICETQLQTYKKKLEDYNDLKKQIKLQEERSADYLKQNLEYEEEAKKYAGLKGQVELYKKKIQDLHGMLDEEMGKTVRAEFEYNQLQGQLAVVQREKETLLSERDTLREALDELKCGQAVGADGVGHGGPGGNTMSKELHSNDVCERIERLERENKALREGQGGQTALSQLLDDANQRNEKLREQLKSANQKILLLSQHHAEDGTTKSELEMQMKQTLELGEQRSSAQQQLDETTQHQLSNLHTKIANLEAALVVKDQELQAADVRYKKCVEKAKEVIKTLDAHAISEALLMDKVDSASGTGVDATLTTVGNGGTAARAPMGQQEEQLIATAFYRLGMVCHREAVDARLLSGPGQSFLARQRQPAARKPLNANYAKK", "function": "Involved in endocytic trafficking. Probably acts as a cytoskeletal linker protein that tethers endosome vesicles to the cytoskeleton.", "AFDB_id": "AF-Q7PWT9-F1-model_v4" }, { "swissprot_id": "C6ZDB5", "sequence": "MKILLFLCFLVSVAFAKPPTIQLKSNTKSQNGFIVGGTEAVDGDAPHQVSLQHTSHFCGGSIISERWILTAAHCIDADDLSNPGGMSVRYNTLNLKSGTLVKVKSIKVHEQYSNVTSDNDIALLETVASMNLNQTNAVAAKLPAKGNDPQDGDLFLSGWGTLHSGDTTIPTNLQKVTVPLTNRSVCAEAYTGIVNITENMFCAGKMGIGGVDSCQGDSGGGAMLNKELVGVVSFGVGCGDPKYPGVYTRVSQYLDWIELSAKSSATTLVAVNITLFLTLFIGAIW", "function": "Digests TAMe (p-toluene arginine methyl ester), but not ethyl N-benzoyl-L-tyrosinate (BTEE).", "AFDB_id": "AF-C6ZDB5-F1-model_v4" }, { "swissprot_id": "Q9XWV3", "sequence": "MPAYHSKFDTELKVLPLGNTNMGKLPIRTNFKGPAPQTNQDDIIDEALTYFKPNIFFREFEIKGPADRTMIYLIFYITECLRKLQKSPNKIAGQKDLHALALSHLLPIPGENGFPLNSMYKAPQSKPDEDEMRAYLQQIRQEIGARLCDLAFPDPQDRPSKWWLCFARRRFMDKGLVGQGVNL", "function": "Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.", "AFDB_id": "AF-Q9XWV3-F1-model_v4" }, { "swissprot_id": "A0LRH8", "sequence": "MTPHDPVSVEAVPKIELHVHLEGTVEPATVLDIAARNGLALPVSTVDELSALYRVTTFSDFLRLWILTTNVLRKAEDFSQVVVDYARRAKRHGAVYIEGIFSPVERVMRGVGWAEIFDGYCEGAERAYAEHGVVVRLTPEAYRGADPELVAEMVRYAGRYRDRGVVGVGIGGDERARPTRHYAAAFAPAVDLGLGVVPHAGEFPLFPDGASGAATLRETIEALNPVRIRHGIAAAADPALVAVIRERGIVLDVCPTSNLRTGAIRDLADHPLPRLAAAGIPCTVGTDDPAVFDTDLSREFTIAARLGVEPRLLYDAGITGALCDDDVKSHLRQIGAATTWPTTTATWSTTAAGESL", "function": "Catalyzes the deamination of aminodeoxyfutalosine (AFL) into futalosine (FL), a step in the biosynthesis of menaquinone (MK, vitamin K2). Is very poorly efficient on 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide (NECA), adenosine, 5'-methylthioadenosine, 5'-deoxyadenosine, 2'-deoxyadenosine, and AMP as substrate.", "AFDB_id": "AF-A0LRH8-F1-model_v4" }, { "swissprot_id": "Q7Z4S6", "sequence": "MLGAPDESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESNREERSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDSTDEDAPLNSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPLTPVAEGQEIGMNTETSGTSAREKELSPPPGLPSKIGSISRQSSLSEKKIPEPSPVTRRKAYEKAEKSKAKEQKHSDSGTSEASLSPPSSPPSRPRNELNVFNRLTVSQGNTSVQQDKSDESDSSLSEVHRSSRRGIINPFPASKGIRAFPLQCIHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLTSSGQVTLGDACSASTSRTVAIPSGENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRTVRIWKARNLQDGQISDTGDLGEDIASN", "function": "Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity.", "AFDB_id": "AF-Q7Z4S6-F1-model_v4" }, { "swissprot_id": "P0CJ78", "sequence": "MEANPAGSGAGGGGSSGIGGEDGVHFQSYPFDFLEFLNHQRFEPMELYGEHAKAVAALPCAPGPPPQPPPQPPPPQYDYPPQSTFKPKAEVPSSSSSSSSSSSSSSSSSSSSSSSSSQAKKPDPPLPPAFGAPPPPLFDAAFPTPQWGIVDLSGHQHLFGNLKRGGPASGPGVTPGLGAPAGAPGPLPAPSQTPPGPPAAAACDPTKDDKGYFRRLKYLMERRFPCGVCQKSFKQSSHLVQHMLVHSGERPYECGVCGRTYNHVSSLIRHRRCHKDVPPAAGGPPQPGPHLPPLGLPAPAASAATAAAPSTVSSGPPATPVAPAPSADGSAAPAGVGVPPPATGGGDGPFACPLCWKVFKKPSHLHQHQIIHTGEKPFSCSVCSKSFNRRESLKRHVKTHSADLLRLPCGICGKAFRDASYLLKHQAAHAGAGAGGPRPVYPCDLCGKSYSAPQSLLRHKAAHAPPAAAAEAPKDGAASAPQPPPTFPPGPYLLPPDPPTTDSEKAAAAAAAVVYGAVPVPLLGAHPLLLGGAGTSGAGGSGASVPGKTFCCGICGRGFGRRETLKRHERIHTGEKPHQCPVCGKRFRESFHLSKHHVVHTRERPYKCELCGKVFGYPQSLTRHRQVHRLQLPCALAGAAGLPSTQGTPGACGPGASGTSAGPTDGLSYACSDCGEHFPDLFHVMSHKEVHMAEKPYGCDACGKTFGFIENLMWHKLVHQAAPERLLPPAPGGLQPPDGSSGTDAASVLDNGLAGEVGAAVAALAGVSGGEDAGGAAVAGAGGGASSGPERFSCATCGQSFKHFLGLVTHKYVHLVRRTLGCGLCGQSFAGAYDLLLHRRSHRQKRGFRCPVCGKRFWEAALLMRHQRCHTEQRPYRCGVCGRGFLRSWYLRQHRVVHTGERAFKCGVCAKRFAQSSSLAEHRRLHAVARPQRCSACGKTFRYRSNLLEHQRLHLGERAYRCEHCGKGFFYLSSVLRHQRAHEPPRPELRCPACLKAFKDPGYFRKHLAAHQGGRPFRCSSCGEGFANTYGLKKHRLAHKAENLGGPGAGAGTLAGKDA", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-P0CJ78-F1-model_v4" }, { "swissprot_id": "Q89AZ2", "sequence": "MLIDIMFEKIGISLFELVTSIIFISWIVKKFILDKNVIIQSYMKVESKISLGYNEKIIIVDIKDVRLVLGVTSKRIVHLYTLPPIVYKKSQDSLIKSSNVGYKRNNYIRTMWNKTMVYQIASLCVFLLFCPSYAYAGIPDVISHTSSDGGQIWSIPIQTLVFITSLTFIPTVLLMMTSFSRIVIVFSLLRSALGTPYSPPNQILVGLSLILTFFIMAPIFDKIYQDSYLPFSEDKISIDTAIVRGAKPLHKFMVNQTRQVDLEFFSKLANISTFSRKEEIPMRVLLPSFITSELKTAFQIGFTIFIPFLIIDLVVSSVLMSLGMMMVPPSTISLPFKLMLFVLVDGWQLLITSLTHSFYH", "function": "Plays a role in the flagellum-specific transport system.", "AFDB_id": "AF-Q89AZ2-F1-model_v4" }, { "swissprot_id": "O88875", "sequence": "MQRILMAPGQSCCALAILLAIVNFQHGGCIHVTSSASQKGGRLDLTCTLWHKKDEAEGLILFWCKDNPWNCSPETNLEQLRVKRDPETDGITEKSSQLVFTIEQATPSDSGTYQCCARSQKPEIYIHGHFLSVLVTGNHTEIRQRQRSHPDFSHINGTLSSGFLQVKAWGMLVTSLVALQALYTL", "function": "The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.", "AFDB_id": "AF-O88875-F1-model_v4" }, { "swissprot_id": "P23796", "sequence": "MVSRLSKRYRSRVQFSISVMDENIYLSLSQINKDIRKENKSVRNRLQSILLDNKFLQDRVIPIFPHYPLIPNERCGLWYCNPSSFKQTSYFKSTDGHVNQWDFSTRRLNFHLLETIRDNKGIIIVDSTRRGKKIPDALSKTVPIWCAVLNTLMLQETEKNVAIDKVLYLPPETVPKSEYDMIKRKIPELVAKLQKLNIIDSKKLNELFMGKLLRPIWVHPGSSLLDHSVDYFTGEVQEYEAWETPEDQNIIPIILCTVSYQAQDGMDKRYGFTYVQGAADDHELWSFGLDSNMFWAHIEYLGDASYSDDQLHDYIMDLAAAKLRNQCYIQDKGSLDEVFGNIDKITNEISLGKVSSGLTINKNLKQKLKSEYGKVIIFSNSVTVAEDTDDEEESGTDPFISIYKLQSGDKKSSKALRSTFPRIHGEIQSLFTNRDEKIKPMLICCNTGTDMSIGVILSILCTKYTEEWMLTSELPDISKLIVRKHLTKLISHLKGRNVNPSRATLNSVNSFLM", "function": "tRNA backbone modifying enzyme that mediates initiator/ elongator tRNA discrimination. This enzyme modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. Recognize the stem-loop IV region that is unique in eukaryotic cytoplasmic initiator tRNAs.", "AFDB_id": "AF-P23796-F1-model_v4" }, { "swissprot_id": "Q7WZ32", "sequence": "MAKEVVYRGSARQRMMQGIEILARAAIPTLGATGPSVMIQHRADGLPPISTRDGVTVANSIVLKDRVANLGARLLRDVAGTMSREAGDGTTTAIVLARHIAREMFKSLAVGADPIALKRGIDRAVARVSEDIGARAWRGDKESVILGVAAVATKGEPGVGRLLLEALDAVGVHGAVSIELGQRREDLLDVVDGYRWEKGYLSPYFVTDRARELAELEDVYLLMTDREVVDFIDLVPLLEAVTEAGGSLLIAADRVHEKALAGLLLNHVRGVFKAVAVTAPGFGDKRPNRLLDLAALTGGRAVLEAQGDRLDRVTLADLGRVRRAVVSADDTALLGIPGTEASRARLEGLRLEAEQYRALKPGQGSATGRLHELEEIEARIVGLSGKSAVYRVGGVTDVEMKERMVRIENAYRSVVSALEEGVLPGGGVGFLGSMPVLAELEARDADEARGIGIVRSALTEPLRIIGENSGLSGEAVVAKVMDHANPGWGYDQESGSFCDLHARGIWDAAKVLRLALEKAASVAGTFLTTEAVVLEIPDTDAFAGFSAEWAAATREDPRV", "function": "Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.", "AFDB_id": "AF-Q7WZ32-F1-model_v4" }, { "swissprot_id": "Q9VD09", "sequence": "MWSRSSSSKRQVATTDGDPERVLAQVQDLSDWLVANPQINGCNTFENLHFFLRTSKFDVERAKKKLKTFYQMRAERTEWFDNRDPQLPEIQDLLKLGVFLPIGPDAEQRMVVVIRTAAHDPKLHSQNNVFKTSKMILDLLLKLDPETCARGMVAILDMQGVQLGHALQMNPKLIKRSVESWTAYPCQPKLLEFTNAPRHVNFFLNTFRIFMTPKIRSRLFVRREGTSVSCDQLPKELGGQGLSYMELSVKWKQLVEENADFYVEQDKYKSKLK", "function": "Retinoid-binding protein which shows highest affinity for all-trans retinol. Can also bind all-trans forms of retinoic acid and retinal, but has lower affinity for cis form retinoids. Required in retinal pigment cells for rhodopsin biosynthesis.", "AFDB_id": "AF-Q9VD09-F1-model_v4" }, { "swissprot_id": "O22267", "sequence": "MMVKVTKLVASRPIVVFCVLAFLVVVFECIWISNWRTTTENLVKEVASFTEDLRTSLVSEIENIGKFTYAKTNLSTIGLARVIDSYITNNDTGFTEIQTQIAPLLFVAYSTILQVSQVSYISRDGLMFSYIAESNTSVAVFANSSSNSSRGDYTWYTQTVDQLTGRLNGNSTKSQSLDVTHTDWFQAAQSNNYTTAFVGTSLGGEDNETLIQSVVSLYSKKGLVSLGFPVKTLTEVLNSLNLHGEELYMWTKDGTVLVREGSLNDSFFISNGSICFGRESNSLWSQCIPENCSSSGYEVEIKRLRYQAFCSVIEVSGVPLRYTLMFPNKGGATRIKHQAEKAKYQLIVVMIFLGFGWPVWFVWFMMQATRREMHMRATLINQMEATQQAERKSMNKSQAFANASHDIRGALAGMKGLIDICRDGVKPGSDVDTTLNQVNVCAKDLVALLNSVLDMSKIESGKMQLVEEDFNLSKLLEDVIDFYHPVAMKKGVDVVLDPHDGSVFKFSNVRGDSGRLKQILNNLVSNAVKFTVDGHIAVRAWAQRPGSNSSVVLASYPKGVSKFVKSMFCKNKEESSTYETEISNSIRNNANTMEFVFEVDDTGKGIPMEMRKSVFENYVQVRETAQGHQGTGLGLGIVQSLVRLMGGEIRITDKAMGEKGTCFQFNVLLTTLESPPVSDMKVRQEIEAGGDYVSTPNLGLTINTSLGGSMNIRNLSPRFNNCLSSSPKQEGSRVVLLLKNEERRRVTEKYIKNLGIKVTVVEKWEHLSYALERLFGFSPQSSMGRAECSLSCPSSRELPFIGMDGIDSRSQLPKRRSISFSAVVLLVIDAKTGPFFELCDIVKQFRRGLPHGISCKVVWLNESSTRVSERGDISCSRPLHGSRLMEVLKMLPEFGGTVLKEPPTELQRESLLRHSFVAERSPKHKVQEEGPSSMFNKKLGKRIMASTDSESETRVKSVRTGRKPIGNPEDEQETSKPSDDEFLRGKRVLVVDDNFISRKVATGKLKKMGVSEVEQCDSGKEALRLVTEGLTQREEQGSVDKLPFDYIFMDCQMPEMDGYEATREIRKVEKSYGVRTPIIAVSGHDPGSEEARETIQAGMDAFLDKSLNQLANVIREIESKRH", "function": "Essential protein. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. Required for the development of megagametophyte in female gametophyte (embryo sac) independently of cytokinin. Contributes to vascular bundle formation and secondary growth in a cytokinin-independent manner, probably by promoting the maintenance of mitotic activity and/or identity of procambial cells. Seems to influence and promote the cytokinin signaling pathway.", "AFDB_id": "AF-O22267-F1-model_v4" }, { "swissprot_id": "Q68EY2", "sequence": "MAFTFAAFCYMLTLVLCASLIFFIIWHIIAFDDLRTDFKDPIEQGNPSRARERIKNVERVCCLLRKLVVPEYCIHGLFCLMFMCAAEWVTLGLNIPLLFYHLWRYFHRPADGSEVMFDPVSIMNVDILNYCQKEAWCKLAFYLLSFFYYLYRVGATVRYVSA", "function": "Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs).", "AFDB_id": "AF-Q68EY2-F1-model_v4" }, { "swissprot_id": "P36108", "sequence": "MSLFEWVFGKNVTPQERLKKNQRALERTQRELEREKRKLELQDKKLVSEIKKSAKNGQVAAAKVQAKDLVRTRNYIQKFDNMKAQLQAISLRIQAVRSSDQMTRSMSEATGLLAGMNRTMNLPQLQRISMEFEKQSDLMGQRQEFMDEAIDNVMGDEVDEDEEADEIVNKVLDEIGVDLNSQLQSTPQNLVSNAPIAETAMGIPEPIGAGSEFHGNPDDDLQARLNTLKKQT", "function": "Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Can directly stimulate VPS4 ATPase activity. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III.", "AFDB_id": "AF-P36108-F1-model_v4" }, { "swissprot_id": "O07427", "sequence": "MTTTRTERNFAGIGDVRIVYDVWTPDTAPQAVVVLAHGLGEHARRYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRDISEYTADFDTLVGIATREYPGCKRIVLGHSMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPGLPVQELDFTAISRDPEVVQAYNTDPLVHHGRVPAGIGRALLQVGETMPRRAPALTAPLLVLHGTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVFNEPERNQVLDDVVAWLTERL", "function": "Induces an inflammatory response and cell apoptosis in the host cells. Increases expression of IL-6, NF-kappaB, TLR-2, TLR-6, TNF-alpha, and MyD88 in mouse alveolar macrophage RAW264.7 cells. Persistent expression induces RAW264.7 cell apoptosis in vitro.", "AFDB_id": "AF-O07427-F1-model_v4" }, { "swissprot_id": "O09159", "sequence": "MGTGPLTSGVRAGGGNTGWLWMSSCNLGSPVLPISFLFWLLLAAPGARAAGYKTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGILSDVQHASVQYILDSVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRKKKLRMEELWRASDSLEPPAADLFTGVLPNNYNPPKYLCWDVLCTDPPVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHYENANMWFKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEANVGPYGSGDSAPLQEAMAVLQHHDAVSGTARQNVVNDYARQLAAGWGPCEVLVSNALARLSHYKQNFSFCRELNISICPVSQTSERFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNVVMVPSYYSETYQWELLFPASVPALGFSTYSVAKMSDLNHQAHNLLSRPRKHKSHHVLVIENKYMRATFDSGTGLLMKIENLEQNLSLPVSQGFFWYNASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLVKTALVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKTKGQFFTDSNGREILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYITDGQMQLTVLTDRSQGGSSLQDGSLELMVHRRLLVDDDRGVSEPLLETDTGDKVRGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYHSRATPKTQFSGLRQELPPQVHLLTLARWGPKMLLLRLEHQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETTLAANQPLSRASRLKWMTNTGPTSYPEPSKLDPTSVTLKPMEIRTFLASVQWQEHRPA", "function": "Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.", "AFDB_id": "AF-O09159-F1-model_v4" }, { "swissprot_id": "O34737", "sequence": "MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDASCLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAVNLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS", "function": "Low-potential electron donor to a number of redox enzymes.", "AFDB_id": "AF-O34737-F1-model_v4" }, { "swissprot_id": "A5DDJ4", "sequence": "MSGSKQGSEKASITSLIDSEEQGDEATSVSTQNQSPKTQITQTENVEVQNSDLKVTENKPKNTEMKPTDPNTNASTTENTPITTSNAQVSEKSEKTVPAWMREPEEAQNRYDRYVPRVDNRRRGEPRVAEVRQDPRYAKYLRQDQEERRIRRPDDEYEGDHKRRRPEMVTQFDDRRQGTRKNHPGQAGQSESEENGDEQQGDDEEETPGNEEPVEAQPYSRLATSVQSTQHYHTFQSHIANKENKDINSIVRSHYNQRTIQSKMQGSRTKSPIYKLRNFNNAVKYMLLGNHVRKNPNPGSPTVILDMCCGKGGDLNKAEFVGADQYVGIDISDASVKEAFHRYRRNKARFIPRDGGRAGQRDSRKYNFEACFATGDCFQQSIPEILEPNFPGIVNGLFPVDCVSIQFSMHYSFESEERVRTMLNNVSKSLRPGGTFVGTIPSSDFIRDKIVNKDFLPGTNNKFGNELYSVTFDRTPPSDGIFRPPFGNKYDYFLKDAVDNVPEYVVPFEVFRSMCEEVGLTLRYKKNFIEIFNQEIPKYFHKLNRNLVDGMKRADGKYGAEGAEKEAVSFYLGFAFEKLG", "function": "Responsible for methylating the 5'-cap structure of mRNAs.", "AFDB_id": "AF-A5DDJ4-F1-model_v4" }, { "swissprot_id": "Q8L7A9", "sequence": "MEQLKTIGRELAMGSQGGFGQSKEFLDLVKSIGEARSKAEEDRIVLSEVDILKRRLLEPDIPKRKMKEYIIRLVYIEMLGHDASFGYIYAVKMTHDDNLLLKRTGYLAVTLFLNEDHDLIILIVNTIQKDLRSDNYLVVCAALNAICRLINEETIPAVLPQVVELLNHQKEAVRKKAIMALHRFHRKSPSSVSHLVSNFRKRLCDNDPGVMGATLCPLFDLISEDVNSYKDLVSSFVSILKQVTERRLPKSYDYHQMPAPFIQIKLLKIMALLGSGDKNASDIMSMVLGDLFRKCDSSTNIGNAILYECIRCISCILPNPKLLEAAADAISKFLKSDSHNLKYMGIDGLGRLIKISPDIAEQHQLAVIDCLEDPDDTLKRKTFELLYKMTKSSNVEVIVDRMIDYMISINDNHYKTEIASRCVELAEQFAPSNQWFIQIMNKVFEHAGDLVNIKVAHNLMRLIAEGFGEDDDDADSKLRLSAVESYLQLISEPKLPSLFLQVISWVLGEYGTADGKYSASYISGKLCDVADAYSSDETVKGYAVSALMKIYAFEIASGRKVDVLPECQSLIEELLASHSTDLQQRAYELQALLALDARAVETILPLDASCEDIEVDKDLSFLNGYIQQAIESGAQPYISERERSGMFETTDYHPQDHHEVPTHALRFEAYELPKPSVPPQASNELVPVPEPSYYSESHQPISTSLVSERESSEIKLRLDGVKQKWGRPSYQSTTAASSTTPQAANGISTHSDAGVGSSSSKPRSSYEPKKPEIDPEKQRLAASLFGGSSSRTDKRSSSGGHKPAKGTANKTATVPKENQTPVQPPPDLLDFGEPTATTATAMDPFKELEGLMDSSSQDGGSSDVMGLYSDAAPVTTTTSVDSLLSELSDSSKGNSRTYQPQTSKGPNTKEALEKDALVRQMGVNPTSQNPTLFKDLLG", "function": "Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.", "AFDB_id": "AF-Q8L7A9-F1-model_v4" }, { "swissprot_id": "Q810F5", "sequence": "MPCACNRNNWRKWIRPLLILLYALAILVTVPVCIWEFQKLKVGIHTKVWFIAGIFLLLTIPVSMCGILQHLVHYTQPELQKPIIRILWMVPIYSLDSWVALKYPKIAIYVDTWRECYEAYVIYNFMIFLTNYLTIRFPNLMLHLEAKDQQNHLPPLCCCPPWAMGEMLLFRCKLGVLQYTVVRPITTVTSLVCEILGVYDEGNFSFSNAWTYLVILNNLSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVLIALLVKVGVISEKRTWEWQSAEAVATGLQDFIICIEMFFAAIAHHYTFSYKPYVHEAEEGPCFDSFLAMWDVSDIREDISEQVRRVGRTMRGYPKKKCFPGDPDHNEHSSLLSASSQDSSKPSSPVGLYQGFGQTITSQSPISIANLYEEILNEIPEEQQRLYSGQDITMDIPEEQPRHDTGQDVVHLPYRQELPYKNHYQDHIQTVTSRYLLSSPKPSDDIVIDFSDSPEGSDSSTDS", "function": "Possible tumor suppressor which may play a role in cell growth.", "AFDB_id": "AF-Q810F5-F1-model_v4" }, { "swissprot_id": "Q9VWN5", "sequence": "MNEKIVREQRGGEDSPSSVSAKSATAAASASTASMTFASAALESHKTTTITTASSSPRTSGASASASSSSRSASAPASSSSQQEKQPMLNATDMRELREIKQLLWGDNVREDVFKRWSQGFEFSKVEPSALVQKQGGPCAVIAPVQAYLLKIIIMDLPGIKLSEISLDKSQNLLIQALCDILKNCRAPRYRIVHLLRRRGNATEAGSTKKRSPAGEEESALAGQAAGSSEEVEEAAEATPASVSKLSQALQLEHDMHQELSPDEFHERLHTLHFKNIAAVARYYMENYDQLAHTYGVLLFMYSVFLTKGLELVAADISDTSEPLIHSTYGYGGQSLINLMLTGRAVAHVWDNEQDVGGLKLRGICEQSDIGFITLMEEMRYCTVGSFFKNPRYPVWVMGSDTHLTVLFSNEKRLVSPETPSETGRRIFKSYDPEGNNFISTTMLREVLIALNLVSEPAYVALMQKRLDPENLGIILLNAFMDEFFPLESRSTPDTFELMHYNGIPGSNENNKVRYYCGTAILLEGDLKSVCTSNPMVTCLQTKWPNIEINWHDGHMPSLN", "function": "Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.", "AFDB_id": "AF-Q9VWN5-F1-model_v4" }, { "swissprot_id": "F2RB77", "sequence": "MTEQNELQRLRAELDALDGTLLDTVRRRIDLGVRIARYKSRHGVPMMQPGRVSLVKDRAARYAADHGLDESFLVNLYDVIITEMCRVEDLVMSRESLTAEDRR", "function": "Involved in chloramphenicol biosynthesis. Probably catalyzes the conversion of 4-amino-4-deoxychorismate to 4-amino-4-deoxyprephenate.", "AFDB_id": "AF-F2RB77-F1-model_v4" }, { "swissprot_id": "Q6L739", "sequence": "MPLQSSRLAVDNGTPVRGKPWPVWPQPTDGTLDALSRVLRSGRWAISGPYRGVESAERRFARRFADYHRIAHCVPASSGTASLMLALEACGVGAGDEVILPGVTWVASASTVVGVNAVPVFADIDPDTLCLDPDAVEAAITPATKAIVVVHLYAAVADLTRLKEVADRHGIVLIEDCAQAHGAEFEGHKVGTFGAVGTFSMQQSKVLTSGEGGAAITADPVLARRMEHLRADGRCYRDQAPPSGHMELVETGELMGSNRCISEFQAAVLTEQLGELDRFNALRRHNAELLDALLTDVGYRPQRSTPGTTARTYYTYVAELPDAELPGADITKVTEALTAELGFPVAPAYSPLNANPLYDPASRSRFALGPQHEKLIDPARFVLPVSGRLTRRLVTFHHAALLGDESDMRDIAEAFTKVLQHRAVLAA", "function": "Catalyzes the PLP-dependent transamination of 2-deoxy-scyllo-inosose (2-DOI) to form 2-deoxy-scyllo-inosamine (2-DOIA) using L-glutamine as the amino donor. Also catalyzes the transamination of 3-amino-2,3-dideoxy-scyllo-inosose (keto-2-DOIA) into 2-deoxystreptamine (2-DOS).", "AFDB_id": "AF-Q6L739-F1-model_v4" }, { "swissprot_id": "G4N5V2", "sequence": "MLPRLATVLLSALGASASVLPTTTTRDLASRAAPVASLCTQYAYLKTNGYEILNNLWGIDTATGGGSQCTYYNGAVGPAVAFSSDWTWRGNDNTVKSYVYANRVFERRLVGDIKSLPTSVQWSYNTTNVRANVAYDIFTHTDVNHPNSSGDFELMIWLQRYGGIWPITESSTGSPVERVTIAGYTWELFTGWNGAMRVYSFLPPSGTSYNSFSADVKLFFDYLGQKYAFPASEQYMLIYNFGTEAFTGGPAHFDVSRFQAEVQV", "function": "Endoglucanase that functions in part to hydrolyze 1,3-1,4-beta-glucan during infection and spore formation. Shows preferential hydrolysis of barley beta-glucan and lichenan, but also hydrolyzes carboxymethylcellulose (CMC) to a slight extent.", "AFDB_id": "AF-G4N5V2-F1-model_v4" }, { "swissprot_id": "Q3UIR3", "sequence": "MASSPDPPSPLLVRLRESIPKAHRKLEIYFQSRASGGGECSVQPVGPSAPDTYEVKFLKKADKEKVLKKSEHEMLVHNKPVTIVLETTKKPVEDLRPRLPSLTQPVETPSSRPPSLTGSLDEALCDDIHPQDGLVSNSVDSVVQKIFLAVTAELNCDLLSKEQRASITTVCPHIIKSMEGSDGIKKVCGNFKDIEKIHHFLSEQLLEREQKRKGSEQKRKCAPQKHTPPDVEREPPDQSSIQVPVLLLEYFKHVNPGRLEFIEYKFGVNIEIQASSPNMVTVGFTSSPFGNVEEASQSFVRDFQKCSQSLKQDCISLEEHQRAKEVRQELSRCFPKLLIKGQGRTLTLLGSPADISAATEKVSQGLGLRPVKITASGYTTGIEVDSTRFKLLEPELLQEISEIEQKFNTRGKVQEKGQKTCILFVPKDKDLDLSVQSYTGFTDAFQRATWQLRTEVLSLKGLGKERARLHNTKFADNFKKEHPNVHFVTSQESVTLTGLPHHLAQAMQYVSKRMGLAPSSGEKLAMDQETPMEISSSDPHGDQQENAALPAPRGTSSSPAASKGTEDYCVICMDTISNKHVLPKCKHEFCTSCISKAMLIKPVCPVCLTSYGIQKGNQPEGTMSYSTQKGSLPGYEGCGTIVINYEIKDGIQTKEHPNPGKAYHGTRRTAYLPDNTEGRKVLDLLHEAFKHRLTFTIGYSRATGVSDVITWNDIHHKTSKFGGPANFGYPDPDYLKRVKEELKAKGIE", "function": "E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication. Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM. In addition, required for the recruitment of HGS and STAM to early endosomes.", "AFDB_id": "AF-Q3UIR3-F1-model_v4" }, { "swissprot_id": "O94531", "sequence": "MTSRTNEFFGLTKNGDIDAANIPLKRISYTDPFLAEGYRIHETIVNLLVFLKKIRGAYLKDRTFSNVQRLSKPLMECSLEELSKLELDEVQRDEIEHEVSSAISSCIHQIAKLQEIVKEQQSQIPKKSGWLQGLRDPSKLSKKETLVAHHSSVLWYLQSELSDVSSVLYHLQDLRLKRGQEKRNIASDFLTKNPTDENSAVEIPESELQTFFTQQQLQELEQENDVLLQEFEHTMERLRDTGKSLADITRLQSEISAQLSIQSSAAEKLYDDALNVMDSLSGGNQQLIKAKSRSSRTARLLFCIFTVMGLLLLSLDRIV", "function": "Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.", "AFDB_id": "AF-O94531-F1-model_v4" }, { "swissprot_id": "Q9NHZ6", "sequence": "MSSILSSNFTNKSNQLVNESAVDSSLTASPCSTQPGDVGWCFDAPHGVLTKLPNETRAIVSAVSPNWRVTSIGEKTLAIMIPHDQPVLGISKKNFVDLLEFAEDKLEMERVLAVFEKARINPTEGFPRTLRYVGFRPYAIDEHPVHLPAEKYFIMSYKV", "function": "Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.", "AFDB_id": "AF-Q9NHZ6-F1-model_v4" }, { "swissprot_id": "A4WN38", "sequence": "MDLLSPLSAVILTYREADANALGRIGEEMRRCIEVIGPKTPMFVLHTCHRVEAYLYGASEEELSSLVERYKRHVESARILRGIEAARHLFRVAAGLESMLLGETDILGQLEEAYDRQVRAGFTRGLLKTVVERAVRVGKKVRTETGISRGPAGLGSLSIIYVSQFVDLKSAKVAVLGAGAVGAGLAKELAERGVAKLYILNRTLEKATEVAKKTGAEARPLTREEVERCLLECDVVFSAVHTLEYVIDMIPPGASVKVVVDLGVPQSVAPGLPIKVVRLSDLAELAQRYSALRKEEAKKAEAIVEEELEMLPKALAKRAVEEAVAEVMARAVEIAEEEGRRAGCEVAQLAAKTTVKRLLLPIVEELKKMAENGRVEHALEVSQIFTRLVGAPHGEPQNLKTVK", "function": "Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).", "AFDB_id": "AF-A4WN38-F1-model_v4" }, { "swissprot_id": "Q9V8Y7", "sequence": "MFKVKDLLLSPTTFEDPIFGTHLRYFQWYGYVASKDQNRPLLSLIRCTILTASIWLSCALMLARVFRGYENLNDGATSYATAVQYFAVSIAMFNAYVQRDKVISLLRVAHSDIQNLMHEADNREMELLVATQAYTRTITLLIWIPSVIAGLMAYSDCIYRSLFLPKSVFNVPAVRRGEEHPILLFQLFPFGELCDNFVVGYLGPWYALGLGITAIPLWHTFITCLMKYVNLKLQILNKRVEEMDITRLNSKLVIGRLTASELTFWQMQLFKEFVKEQLRIRKFVQELQYLICVPVMADFIIFSVLICFLFFALTVGVPSKMDYFFMFIYLFVMAGILWIYHWHATLIVECHDELSLAYFSCGWYNFEMPLQKMLVFMMMHAQRPMKMRALLVDLNLRTFIDIGRGAYSYFNLLRSSHLY", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Specific receptor for geosmin, a microbial odorant that constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes and induces avoidance behavior.", "AFDB_id": "AF-Q9V8Y7-F1-model_v4" }, { "swissprot_id": "O74972", "sequence": "MLILKRIFIIRNFIFPFSNCRYASTVPSPRSGISNTNDFFKRIGRDTAEKVNGKFESWDGLFRKSTKTMKKEGIDVRTRKYIASQRNRFKEGFIVKPYPVMVKKNGGERRKRK", "function": "Involved in telomere length regulation.", "AFDB_id": "AF-O74972-F1-model_v4" }, { "swissprot_id": "Q00986", "sequence": "MKRIRLVDLPLIIKIGFAPAFALLMLAVMAGGAILVQKSQSAALKQVVERDMRQNLEIQRISKRISNINGELFVVMTHKAGNIDVDKNDARMAAVLVETDAVKKDLLALKSKLPAEEQPKIAELIKSLEECRSAIDTVSGMISVDFNMAAGFIAPFEEQYVKMTGQLDQVVAAANQRIESESAKRQAQATAAMSVTIIMSLLTLGAVGALAFLTVMTTRKSINDIAAATDKLSKGDNSIDLEKMTRGDELGGIVTALKVFRDNQVHLEQLRADQEKSAALTADERRSKEAAAAAAAQEASLVVSNLAEGLEKLASGDLTFRVTADFPGDYRKLKDDFNAAMGSLQETMKVIAASTDGLSTGADEIAHASDDLSRRTEQQAASLEETAAALDELTATVRRTAAGARQASDVVSTTRGEATHSGQVVHQAVSAMGEIEKSSGQISQIIGVIDEIAFQTNLLALNAGVEAARAGEAGRGFAVVAQEVRALAQRSAEAAKEIKALISSSTQQVSQGVSLVGQTGEALQRIVTKVGEIDALVTEIAASAAEQATGLNEVNTAVNQMDQVTQQNAAMVEQSTAATHSLKGETAELVRLMARFQVGSGSSSYARPAVADAGHHAPARNPVAEQQARLNTFARPGRSSGSAALAQAPASDGWEEF", "function": "Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation.", "AFDB_id": "AF-Q00986-F1-model_v4" }, { "swissprot_id": "B6IPE2", "sequence": "MTGGVPSLGFACQPDAAEALERWGRWLEHERGASTHTLRSYRADLAGFLAFVAEHRGRPPGLNDLGALDLGAFRAWLAARAADGAGAATRSRGVSGVRSFFRWADRSGLLHNPAIALLTAPKAQRPLPRPLAADDAALLLEEAAAVPEAPWIGLRDRALFTLLYGCGLRISEAIGLNRSDLPAGAASVRVLGKGGKQRDVPVLPAVREAVAAYLAAVPWGGGRAAPLFVGAKGDRLSPDVARRQMRHLRALLGLPDSTTPHALRHSFATHLLGGGADLRAIQDLLGHASLSTTQRYTDVDAEHLLSVYETAHPRARRQGHQTVRSVCDALPPRLRNQESER", "function": "Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.", "AFDB_id": "AF-B6IPE2-F1-model_v4" }, { "swissprot_id": "Q1D375", "sequence": "MSGARRGNGVRLRKGKLIPRDDGKRIEEFVGAATTSTDSASVARMLAPPGWSEPAQRPEFDEVVIVLTGELTIVVEGRRERISAGEVGLVPRGKRVVYRNDGQGACDYWSVCAPAFRPELAHMETPKPRVQENHVTIQVAHGQGRDFARLLTTWARAYLVQLELSGVELSLSLVDDRAIRRLNRTWRKKDKATDVLSFPAGDLPKGTPGPRPLGDVVISLDTAKRQAKEYGRTLESEMARYLAHGLLHLLGHDHERPRDAKRMAALEEQLLGERGMVADSLQVDAKARRARSLM", "function": "Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.", "AFDB_id": "AF-Q1D375-F1-model_v4" }, { "swissprot_id": "Q8JFZ2", "sequence": "MPGYVLTYFPVRGRAEPIRLLLADQGISWKEDEVQIPDWFSGKDARKKEAVFGQLPQFQDGDYVLYQSNSILRYLGNKHGLTGANDEERGHIDMVNDGVEDLRQKYGRLIFFEYETGKDKYLKELPSQLDFFERILSKNANGSKFVVGQKISFADYNLLDILQCHLDLCSKSLSAYPLLTAYVERLVARPKISEYLKSDARNKRPITPKHKK", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Highly active towards 1-chloro-2,4-dinitrobenzene and organic isothiocyanates, but shows no detectable activity towards 1,2-dichloro-4-nitrobenzene, p-nitrobenzylchloride, trans-4-phenyl-3-buten-2-one (tPBO) and ethacrynic acid. May be associated with cellular proliferation.", "AFDB_id": "AF-Q8JFZ2-F1-model_v4" }, { "swissprot_id": "O34627", "sequence": "MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQGFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMFWNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISALPLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLTGTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM", "function": "Exhibits the same spectroscopical features and blue-light induced photochemistry as plants phototropins, with the reversible formation of a blue-shifted photoproduct, assigned to an FMN-cysteine thiol adduct. Although it is a positive regulator in the activation of the environmental signaling branch of the general stress transcription factor sigma-B, its precise role is undetermined.", "AFDB_id": "AF-O34627-F1-model_v4" }, { "swissprot_id": "Q8LBW2", "sequence": "MGYEPDPDALRWGLHDLEVCTLTNAGSCSSVTRYESGGGGTQGYVREGYNQPVTGYVDNDAVIAQFYQDELSRVARAEASGINSLSPTSVVAQDWPHPHQGQENQGEAIDITQESDILHNHNGNMEDKNVARIRFEGGQSSPSRDDDSVCSVEIEEESWSEVGKRLNQMIPIAHVPKINGELPSEDEQISDHERLFQRLQLYGLVENKIEGDGNCQFRSLSDQLYRSPEHHNFVREQVVNQLAYNREIYEGYVPMAYNDYLKAMKRNGEWGDHVTLQAAADLFGVRMFVITSFKDTCYIEILPHFQKSNRLICLSFWAEVHYNSIYPEGELPIPEGKKKKKYWVF", "function": "Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (Probable). Cysteine protease with a preference for 'Lys-63' and 'Lys-48' -linked ubiquitin (UB) tetramers as substrates. Cleaves also RUB-GST fusion.", "AFDB_id": "AF-Q8LBW2-F1-model_v4" }, { "swissprot_id": "Q558Y7", "sequence": "MDVDHEVKELVKFIKKLGTKGADGKYSVKYGVLFNDDDVANFFEALVGTLKAAKKRGIITFQGEILLQRVHDNVDVILLKDE", "function": "Modulates actin dynamics and cell motility.", "AFDB_id": "AF-Q558Y7-F1-model_v4" }, { "swissprot_id": "A0A1L9WUS5", "sequence": "MMSAAICTLLAVIATTSLGLLFLSIIRRGKLPPGPPPKPIVGNLHQFPKVNRAQVFDQWHRTYGPIVGLRLGLKKLILVGSYQVARELLDRRGAIYSSRPRVVMAGEIANRGNHTALMPYGPKWKLHNRVHSALMNPTMVKRYQYLQDIESRQLVHDLLQGSTSDFGARIHRYSSSLLFALAYGRRLPTSDAFEIQENAHIAHQFINNLAAGRWLVDAFPVLNYLPTWLAPWKKIGEQLYQRKFGLLQRHTALALEKPVWNWTKHFHGPKKPAEASWEELLNIIGVLYEAGADTTTSALEAFVMAAVLHPDAVRRVQAEIDALVGGAARMPSFEDVQQLPFVDAFVNETMRWRPIAPEGVPHSLMKEDEYEGFTIPKNSIVIANQWHMAMDPATFTDPQAFRPERWLEDPKLPISAFGFGRRACPGRHIALNSMKIVMCRLLWAYDFDHAYENGRKVTIDPDNFVREGVLSKPAPFKAALRVRSPAHEKTIQSALRESEQDEDKILAHIAAGLA", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aculenes, a unique type of norsesquiterpenes that contain a nordaucane skeleton linked to an L-proline moiety and are of mixed biosynthetic origin. The pathway begins with the synthesis of dauca-4,7-diene by the terpene cyclase aneC using farnesyl pyrophosphate (FPP) as substrate. The cytochrome P450 monooxygenase aneF then performs the initial oxidation at C-12 of dauca-4,7-diene to yield asperaculane D. Asperaculane D is substrate of the cytochrome P450 monooxygenase aneD for C-10 hydroxylation to yield asperaculane E. The cytochrome P450 monooxygenase aneG then converts asperaculane E into aculene D via C-2 oxidation. The monomodular nonribosomal peptide synthtase aneB adenylates L-proline and the thiohydrolase aneE transfers this activated L-proline derivative to aculenes D and C to produce respectively aculenes B and A. The dioxygenase aneA converts aculene D into aculene C, and aculene B into aculene A by introducing the 5,6-alkene moiety. Asperculanes A, B, C and F, as well as 14-prolyl asperculane C, might be shunt products of the pathway.", "AFDB_id": "AF-A0A1L9WUS5-F1-model_v4" }, { "swissprot_id": "Q8N6Q3", "sequence": "MSAVLLLALLGFILPLPGVQALLCQFGTVQHVWKVSDLPRQWTPKNTSCDSGLGCQDTLMLIESGPQVSLVLSKGCTEAKDQEPRVTEHRMGPGLSLISYTFVCRQEDFCNNLVNSLPLWAPQPPADPGSLRCPVCLSMEGCLEGTTEEICPKGTTHCYDGLLRLRGGGIFSNLRVQGCMPQPGCNLLNGTQEIGPVGMTENCNRKDFLTCHRGTTIMTHGNLAQEPTDWTTSNTEMCEVGQVCQETLLLLDVGLTSTLVGTKGCSTVGAQNSQKTTIHSAPPGVLVASYTHFCSSDLCNSASSSSVLLNSLPPQAAPVPGDRQCPTCVQPLGTCSSGSPRMTCPRGATHCYDGYIHLSGGGLSTKMSIQGCVAQPSSFLLNHTRQIGIFSAREKRDVQPPASQHEGGGAEGLESLTWGVGLALAPALWWGVVCPSC", "function": "In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis.", "AFDB_id": "AF-Q8N6Q3-F1-model_v4" }, { "swissprot_id": "Q944L7", "sequence": "MSSRENPSGICKSIPKLISSFVDTFVDYSVSGIFLPQDPSSQNEILQTRFEKPERLVAIGDLHGDLEKSREAFKIAGLIDSSDRWTGGSTMVVQVGDVLDRGGEELKILYFLEKLKREAERAGGKILTMNGNHEIMNIEGDFRYVTKKGLEEFQIWADWYCLGNKMKTLCSGLDKPKDPYEGIPMSFPRMRADCFEGIRARIAALRPDGPIAKRFLTKNQTVAVVGDSVFVHGGLLAEHIEYGLERINEEVRGWINGFKGGRYAPAYCRGGNSVVWLRKFSEEMAHKCDCAALEHALSTIPGVKRMIMGHTIQDAGINGVCNDKAIRIDVGMSKGCADGLPEVLEIRRDSGVRIVTSNPLYKENLYSHVAPDSKTGLGLLVPVPKQVEVKA", "function": "Shows phosphatase activity, hydrolyzing the artificial substrate para-nitrophenylphosphate (pNPP) in vitro.", "AFDB_id": "AF-Q944L7-F1-model_v4" }, { "swissprot_id": "Q54CY5", "sequence": "MNKILLKRQILYNLPKYFKNNIPYTITINKSNQFINNNCKNNNNNFRKLNFTTTTTTTTTAPITNNKPKSNMLYSPKDRSYEEAVNALLTLQSNQTVIISWTKERRDNKEESAKFLMEEMRNYCKTLSIDLERESIIHVAGTKGKGSTCAITESIIREQGFSTGLFTSPHLISPRERIRINGEMISKEMFSQYFWNCWDLLIKDYQTQLPNFFRYLTLMALKIFQDEAIQCTILEVGIGGRMDSTNVFPKPMVTGISALGYDHQNLLGNTLAEIALEKAGIMKVGIPIFTVSSQLPEAINVLIDHSNKVKSPLSIVPSIDQYTISSGGGNNNNNKIESIGLKGTHQLENASLAIALANCWFKKQTFKDVNEIFNSENHKQYNYETNNYNVTQFTPLLKSIELGLKNCEWAGRAQHFTNPSHFPNMDFYLDGAHTVESSIVMLNWWKSIVNTTTTTTTTTTTTTTNNNDDDTIHILIFNSTGGRNPTSFLTPIIQSIDNKEIPIFNKSIIPNIIIEKPIDKKYYINEIIQSNQSSTATTTPIPDNAAVKQTTEIKESSTWEDFVVECYDKLSKKSHPCITADSIESSIEIAKELSENGTKNVKVLITGSLYLVGGVLKVLLKEKSFN", "function": "Conversion of folates to polyglutamate derivatives.", "AFDB_id": "AF-Q54CY5-F1-model_v4" }, { "swissprot_id": "Q5TJE2", "sequence": "MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTTITPAAATSATVPGAGVPSGSGATVVPATVGSVRSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFPASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCHDGGDERGPVVPGAGLRRPTYAPPSIMPQKHWVYVKRGGNSPAPAPLVPQDPDLEEDEEEDLVLTCEDDEDEELGGGSRVPEAGGREATLSISDVRTLTEPPDKGEEQVNFCESSNDFGSYDGGGPGAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSSSSSQAPGQPPGNQAEHGAVTLGGTSSGALGMPGGPGGTPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERRHRLVGGGGGGGPGPGGPTGPTLPLKRESPGAGGGSGDEASGATPQSSRRVWSPPSVHKVEMGFGGGGGTN", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q5TJE2-F1-model_v4" }, { "swissprot_id": "A6ZXB7", "sequence": "MSLSNKTVKELRQLLKERYTVEDELTESIALSSMRFKPSQEPEFHALSQSSLLKTKLKQQSSTDIPSYTHVLISKLSCEKITHYAVRGGNIEIMGILMGFTLKDNIVVMDCFNLPVVGTETRVNAQLESYEYMVQYIDEMYNHNDGGDGRDYKGAKLNVVGWFHSHPGYDCWLSNIDIQTQDLNQRFQDPYVAIVVDPLKSLEDKILRMGAFRTIESKSDDNSATSYYELETIIFDSELNRALFETKLNLHCVIEDDESEQISLNRLIDSMKQYSYLMDSKNVRTRIKLATTSERVSNENKKNIDYQNRSTRSQFCLNTQRGDSTETSSFGSMFSGDNTSDVDMEDRNLTEFDSTDTSLCINGEPSIHVNRVERSSRSTDNFHNSKKRMNSNQEKCHDEGNDMLQRNVLETDYARAKNRILASKIKQYERLRFYKDTFTL", "function": "Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.", "AFDB_id": "AF-A6ZXB7-F1-model_v4" }, { "swissprot_id": "Q9Y3A2", "sequence": "MAAAFRKAAKSRQREHRERSQPGFRKHLGLLEKKKDYKLRADDYRKKQEYLKALRKKALEKNPDEFYYKMTRVKLQDGVHIIKETKEEVTPEQLKLMRTQDVKYIEMKRVAEAKKIERLKSELHLLDFQGKQQNKHVFFFDTKKEVEQFDVATHLQTAPELVDRVFNRPRIETLQKEKVKGVTNQTGLKRIAKERQKQYNCLTQRIEREKKLFVIAQKIQTRKDLMDKTQKVKVKKETVNSPAIYKFQSRRKR", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA.", "AFDB_id": "AF-Q9Y3A2-F1-model_v4" }, { "swissprot_id": "Q7KRW8", "sequence": "MASEGENVVMESPGRRTRSGRKAASPAASLPTRSTRRTSKRNVQLSDHEEEAEEQVVMVQEEEEPFRGTNTAEAPALEPQFEETQHQIEDDVEMLPAEAAGVDEKSSSFPFGTVAELHSETSDDIKETRGQAGVDTLLASLAGDNANSLPSVGGNDESDNVKKADFEYNVDSLQPQMEKMNSSEDSSSQHAIAEDLADADTSNATIVNTEIVSEDELPLPSKPEINDAEEVSDEELPAPQRAELPEDAEVISEDELPASNNNNTATEPKAPLKRKAENESVKSTEDKDASSHESSTKDKSSEQYNPGSPTSESNDAQPSEKKLKVEESEPKEKKKEKERDKDKEKDKDKDNNKDKEKERKKLPDLDKYWRAVKEDSTDFTGWTYLLQYVDNESDAEAAREAYDTFLSHYPYCYGYWRKYADYEKRKGIKANCYKVFERGLEAIPLSVDLWIHYLMHVKSNHGDDETFVRSQYERAVKACGLEFRSDKLWDAYIRWENESKRYHRVVQIYDRLLAIPTQGYNGHFDNFQDLINQHDVTITLANEEVIRLRKDFHERQQSKSSKSSSKHRRDSSSSSKDKDSKEREREKDKDKDKDKDKEKRETVGGGVGKSPKDTSETQVDESDSTTDLTTESESSHAASKPAMQIDFSDLSTLNDEEVVSIRDRAISARRKVHKLTVSAVTARWSFEEGIKRPYFHVKPLERAQLKNWKDYLDFEIEKGDRERVLVLFERCLIACALYDEFWLKMLRYLESLEDQSGVVDLVRDVYRRACRIHHPDKPSLHLMWAAFEECQMNFDDAAEILQRIDQRCPNLLQLSYRRINVERRRGALDKCRELYKHYIESTKNKGIAGSLAIKYARFLNKICHDLDAGLAALQQALERDPANTRVALQMIDLCLQRPKVDEQEVVEIMDKFMARADIEPDQKVLFAQRKVEFLEDFGSTARGLQDAQRALQQALTKAKEAQKKSDGSPSRKNSSSSKEGPVPTGSAAAAYNNGGSAAAVAGYNYGAANPYYGQQNTAAAYPSQTPQQASYDSYYNQWGYGSGGASANSGGSGYNYGQWSGYGNYY", "function": "Involved in pre-mRNA splicing.", "AFDB_id": "AF-Q7KRW8-F1-model_v4" }, { "swissprot_id": "B3EI21", "sequence": "MKFAIVANTERKEAVLLAKELTGWLDSKRVSYVLESLSAEKLGIGPSAKIDDLNRICDIFISLGGDGTLLLASHYSETKPVLGINVGHLGFLTEFNKDEMIGAVEKVLDGSYSIHNRTQLEATTMCNGREQRMCALNDVVIEKGTYPRIPTFVIRLDGELLGSYRADGIIIATSTGSTAYSMSAGGPIIAPKSSVFVITPICPHMLTVRPIVISDDKVIEVSVDAQAGEFPLNCDGRITRMLQPQETVTVKKSNDLINLVANEERDYCEILRTKLLWGREHASSQPE", "function": "Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.", "AFDB_id": "AF-B3EI21-F1-model_v4" }, { "swissprot_id": "Q7MV19", "sequence": "MRLSELHTGDQAVIVRVEGRGVFRKRILEMGFVHGKTITVVQCAPLRDPVYYRIMDYNVSLRREDAAKIEVELISSNATSSPASNDIGEQSANPDSNESIPTNPTEDISAKTKSEIEIEVKPNGHVIRVALIGNPNCGKTSIFNRASGAHEHVGNYSGVTVEAKEGLFRHGDYKIEIIDLPGTYSLSPYSPEELYIRQYLSEETRPDLVLNVVDTCNLERNLYLTLQLKEMGLPVVIALNMFDEFEKKGDTFDYPALSAMLGIPMVPTVGRTGQGLPELFDTLISIHEGRNKIIRPIRINYGSIIEPAVEALTEKINNQLSLPYSLPARYIAVKLLEGDKEMNRFVGEQPKGLFILSARDFALREIDEHLTVARDAESIITDQRYGFIAGALKETYRSSYKQLKTLTDKIDHIVTHRVLGFPLFLLFMFIMFEATFVLGRYPMDWIEAGVGWIGSMVNTFMPDGSFKDLIVDGVIGGVGGVIVFLPNILILYFFISLMEDSGYMARAAFIMDKIMHRMGLHGKSFIPLIMGFGCNVPAIMATRTIESKQSRMITMLVTPLMSCSARLPVYLLLAGAFFPDSAGLVLFGLYFLGILLAVLLARLFKKTLFKVEDVPFVMELPPYRMPTSRSVIVHMWNKAAQYLRKMGSIILLASIVIWFLSYYPRYSEEAVLISQIEQIEGNPQLDEEKKTSQIEELNRKAHIEQQEQSYIGRFGKAVQPVLAPIGFDWKMSVSLLTGMAAKEVVVSTLGVIYTGDSDDSDEAARRLGERIREDRDAEGNHTFSPIIALALMAFVLIYFPCIATVVAIGRESGHWKWAVFSIIYSCSLAWIVSFLIYRIGILFF", "function": "Probable transporter of a GTP-driven Fe(2+) uptake system.", "AFDB_id": "AF-Q7MV19-F1-model_v4" }, { "swissprot_id": "Q6CKL5", "sequence": "MRRSPSFQISTKNSAKPTTSIDLTNHLSARGGLFYQDIDTGTTASIKAKNDPNLLAATYDHSISADTDLNIDLQSLITSELNSLYPLTLNQETSNKSANTTKFIDERGGKDKHFFVFTSAGKLVFSQWENENHAMGLTGIIHTVMNYFNINDNTAMRQFTMYGKDGIMTRFVFLDKNHIKLMVQCNNNYESTAQLQQQLDLVYSYIISSVSQRNLNKLMLKRSNFDLQHYLTDLDQQLLKSLCESLATQPKLTWFANSLECLPMSPKKRNAINSILSTTYLDFNISNHNGQILYTLVTSLDMRLISILRPSNHTLHTMDLQILFEVVRAQLTDLLLDKVLWFPICFQKFNDNGFLYALIKVLPNNTIMMVISSQKNAFDILNEFVRRIEDKMIDDNTCNNLELQLLDWHKKFPYINHFIYKMKRTVQIYTPSQPTNEMLQFYYHLKNLCEDDKGTNLNKSSVAMLKWKNDATPGLLSGVYWATEKFELYILLNDINLSNQSILKSAKLLIQHIREIESYLFISRGVTF", "function": "In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.", "AFDB_id": "AF-Q6CKL5-F1-model_v4" }, { "swissprot_id": "B8CZ13", "sequence": "MINNEVSRKYSSALLEVALESDNLSRFKEELEGISKALKQYDDLKKILYHPRVLPDDKKEVIHQVFSDKVSEPVFNFLNLIVDKRREVYLDFIIRDFIKQANRKEGLVKIEVVSAIELSEKQREQLKNKLKKALNKKIELKTKIDPGIIGGIIIKIGDRLIDGSIKHQLDSIKESIEKIPVTELGVIQNES", "function": "This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.", "AFDB_id": "AF-B8CZ13-F1-model_v4" }, { "swissprot_id": "Q86IZ9", "sequence": "MDNSIFYSLGNGIKFNKNKYKKEIGIFNGITSHELDKQTKTNNKVHFFKNTTPSTPVISKKDNIKQKKEEEEDNDNDNEESKEDDDFVEDDDNDDDDDDDDEDEENEEPKEKEFIKHQVNNDEEEEDITLFNKSNENENSDDSDDSDDSGKNKNKNKNKKVSKETQEDKHKREIATFRNKHRIKVDGTDIPDPMTEFSQLENRFKVRKYLLNNINEIGYKEPSPIQMQVIPILLKEREVVAIAPTGSGKTASFSIPILQALYEPKKEGFRSVIIAPTRELAQQIYRNFRLLSKGKPFRICVLSKNLHNQSTNENLIKNYDILITTPLRLVYLIKENLLSLNKVEYLVFDEADKLFDKNFQEQVDIVVTACQNPKLKICLFSATMNQQVEELGHSIMKNPIKIIIGEQNAAAITVDQKLIYVGKEEGKLLAVRQLIQKGLEPPILIFTQSKERAHDLFQELIFDGINVDVIHSERTQFQRDTIVKKFRMGKIWVLICTELMARGMDFKGVNFVINFDFPHTLASYIHRIGRTGRAGRPGVAYTLYTDADTPMLPTIVHAMKQSGSHVPDWMLNLKVQGKKKQQYRLKGVERESFSTIPLSERTSSKFKLRKNKKSFNLPGDQQKSNENNNNNNNNNNDNKKRKSFNNNGEKNNNPERKQKQIKKPKKII", "function": "ATP-binding RNA helicase which may be involved in the ribosome biogenesis.", "AFDB_id": "AF-Q86IZ9-F1-model_v4" }, { "swissprot_id": "P48823", "sequence": "MSFITSAHATAAQVPLTTSQMLGQKLMLDFRYYCGESKKPSGDCRAAMTTLPPELSELISRYDIGGAILFAENVQNTAQIISLTNALQSAAQQSKSQLPLFIAIDQEGGRVARINREQATSFTGNMSIGATYPKQGDIYATKVASAIGKELNSLGINVNFAPTVDVNSNPNNPVINVRSFSENPTVVTKLGLAQVKAFEAAGVLSALKHFPGHGDTHVDSHTGLPRVDHDRDKINQQDLLPFAEIIKASPPGMIMTAHIQYPALDNSKVVNSQGESMIRPATMSYQIMTQLLRHELGYQGVTVTDALDMAGISDFFNPVDATIETFNAGVDIALMPIAIRNRADIKRFEQYMAQLADALETNKLNQEQLSSSMARIAKLKTKLPQSSASLAIANSTLGNPSHRRLEAELALAAITEVKNDGVLPLRDNAQVVHLIMPDRQKCFALEQALQTYSKNSLTLSCTSLQAYDPDIAHDAIKQADMIIAAHASPPQSAVEIGGMDDVKKLREHGVARNVQPAALKALLQYGQQQGKKQLFISLRAPYEISTFGPLSNAVLASYAYNVDVNHDKKVAGPAYTALAKVILGIAKAEGSLPVTVNH", "function": "Most active towards p-nitrophenyl-N-acetyl-beta-D-glucosaminide(PNP-beta-GlcNAc) and diacetylchitobiose.", "AFDB_id": "AF-P48823-F1-model_v4" }, { "swissprot_id": "Q4FVL3", "sequence": "MSIASTQADKKSSNHPDKIKISGVILVDKPQGMTSQQVVSKVKYLFKSPNHDSKKAGHTGTLDPMATGLLPICLGEATKFSHYQLDADKSYQATILLGSQTDTGDADGQVTAEATISAFDDTMLDKIAQQFLGAQQQIPPMYSALKKDGKKLYEYARAGIEVDRPPRDIILKAIELKAIDEQQIQLTVTCSKGTYVRVLAEDIAKAIGTLGHLTALSRLQVGDFKIDETITLANLEALALEQRQTYLLPVDACIDINAELTLSSEQCERVQMGQRLNVIDQLTNDLQSYITSAIEQHLSTSNKNAAVNQNVEDDNDDNDDNDDNDDNDDNDDNDDNDDNAQQLLHEIPVDIRLIDEHGTFIGLGAVSLNGRLQPKKLIQL", "function": "Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.", "AFDB_id": "AF-Q4FVL3-F1-model_v4" }, { "swissprot_id": "Q9Y3Q4", "sequence": "MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLPSNL", "function": "Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.", "AFDB_id": "AF-Q9Y3Q4-F1-model_v4" }, { "swissprot_id": "O22951", "sequence": "MKSGASAASPTAKSFNFGSSRLLALAQQLRVYKPPLSSSFDEREELLAYKESTRKSITHVGFQESMAPVRFRPKKAAVLICLFEGDDGDLRVILTKRSSTLSTHSGEVSLPGGKAEEHDKDDGITATREAEEEIGLDPSLVDVVAFLEPFLSQHLLRVIPVVGILWDRKAFNPTPNPAEVEAVLDAPFEMFLKDENRRSEEFDWMGEKHLVHFFDYKTGDSDYVIWGLTARILIRAATVVYQRPPAFIEQKPNLKYSKMNQATRLYGWLKPLANLHESCENGRLLGHVPAYCLRYLVGISSR", "function": "Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.", "AFDB_id": "AF-O22951-F1-model_v4" }, { "swissprot_id": "Q54JW5", "sequence": "MEDEKNENLMTFIQFCATFITITLFIMPLKTIRLIIEKKNVGTVAGLQFISSVLNCFLWISYALLTSNTTMLFVNSIGMMFSIYYVFNYWKNINQVRASRDYLKKVMIACVLAITIISISYYNTVDDLDTRISRLGFLSSVVCVLMFASPLEKMAIVIQSKNSEGMIINVAILSLLCGLSWTIFGLLLNDIYIYLPNILASILSFVQLTLIKLYPPQILL", "function": "Mediates both low-affinity uptake and efflux of sugar across the membrane.", "AFDB_id": "AF-Q54JW5-F1-model_v4" }, { "swissprot_id": "P22203", "sequence": "MSSAITALTPNQVNDELNKMQAFIRKEAEEKAKEIQLKADQEYEIEKTNIVRNETNNIDGNFKSKLKKAMLSQQITKSTIANKMRLKVLSAREQSLDGIFEETKEKLSGIANNRDEYKPILQSLIVEALLKLLEPKAIVKALERDVDLIESMKDDIMREYGEKAQRAPLEEIVISNDYLNKDLVSGGVVVSNASDKIEINNTLEERLKLLSEEALPAIRLELYGPSKTRKFFD", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.", "AFDB_id": "AF-P22203-F1-model_v4" }, { "swissprot_id": "B2RPY5", "sequence": "MDFVQHALLTASRGALTMSLNSSLSYRKELSNLTATEGGEGGAVSEFIAIIIITVLVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHQEPGYTIFWQIWCALFPFLIMLVCYGFIFRVARVKARKVHCGTVVTVEEDSQRSGRKNSSTSTSSSGSRRNALQGVVYSANQCKALITILVVIGAFMVTWGPYMVVITSEALWGKNCVSPTLETWATWLSFTSAICHPLIYGLWNKTVRKELLGMCFGDRYYRESFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQSLGHSSSTGDTGFSYSQDSGTDVMLLEDGTSEDNPPQHCTCPPKRRSSVTFEDEVEQIKEAAKNSLLHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLFTARTVPGAGFGGRRGSRTLVNQRLQLQSIKEGNVLAAEQR", "function": "Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown.", "AFDB_id": "AF-B2RPY5-F1-model_v4" }, { "swissprot_id": "Q9NRH2", "sequence": "MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHGSTKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELERIKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI", "function": "May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.", "AFDB_id": "AF-Q9NRH2-F1-model_v4" }, { "swissprot_id": "B5RTW5", "sequence": "MAPKRHLGLGKAAKSKKQKKDDSSEVENPVQQSNELTVELNEEVDANDEVSQLRALWKTHAKSDKDNELVVNGIIHECDRLLRNSNLAENEDGEDKNKASTNEDGPKELPADFHSIYALALADLALFHSTDVNKVKEFFDAALERVDLGLQSHTGSIELLFTKSRILINQIPLQYISQLTVESKVQDGVPKIDEKLDAALKIYEEAENQAKALKQYELFNEDNLEILQAFDDLLEIVDNFGKDNSEGDESDKEDDGDYEEEIQLSKKHPLYGIRNTDKYNEWWRDHTIQFLQNVDQQLEKLGISYKQENETENALLPLRREICKRIGQSYLQEAEIPSTVFTTLKYDEGFADVDQLEGLTRDESQKISQYLFKTALDYLKMAEDKEEPESWVNIAESMISLGNLYELDSEEQENYYTEAEKILTKANNATNGKYEDILENLQT", "function": "Required for correct translation termination and probably involved in regulation of hypoxic gene expression.", "AFDB_id": "AF-B5RTW5-F1-model_v4" }, { "swissprot_id": "Q91513", "sequence": "MMTKVGEVLLLLLLPAFVPHTDGTHYSLPGKPTEIKCRSPEKETFTCWWKPGSDGGLPTTYALYYRKEGSDVVHECPDYHTAGKNSCFFNKNNTLIWVSYNITVVATNALGKTYSDPQDIDVVYIVQPHPPEKLEVTVMKDQGWPFLRVSWEPPRKADTRSGWITLIYELRVKLEDEESEWENHAAGQQKMFNIFSLRSGGTYLIQVRCKPDHGFWSEWSSTSYVKVPEYLHREKSVWILVLVFSAFILLLLTWLIHMNSHSLKHCMLPPVPGPKIKGFDKQLLKSGKSDEVFSALVVSDFPPTTSNYEDLLVEYLEVYMPEQQELMVDKGKDHDGCLKSIGSASDSDSGRGSCDSDNLLMDKSGAPKEEQQQQNQEGDQIGKETQGPKEAWEKEAMPCANEDVVSPDASSEKVKTWPSVFSPVTPYSPLDPHNSLEMHKQHCLSNTQFPPGSPSSDHYIKEALQSSYWEVCFNNNQPYPQTEVHPQLQAHSDRNISAVNDRNAPTGLLLPTRMTEYVEVQRVNEENKVLLHPIPSGHSREKACPWVGQRDDYSKVKGVDSDNGLLLQREVVEEESMEMAGAAESCYTSSIAFTTPKQTACSPVALPVQDERVLAVSGYVDTATVFSVHT", "function": "This is a receptor for the anterior pituitary hormone prolactin.", "AFDB_id": "AF-Q91513-F1-model_v4" }, { "swissprot_id": "Q1JUP5", "sequence": "MQQIHPAGQATLLADTRNTLGEGATWCDRTRALYWVDIEGAQLWRCRADGSDLTPWPMPERLACFALTDDPDVLLVGLATHLAFFDLRSGAFTRIVEVEPELPTRLNDGRCDGSGAFVFGMKDEGAEPPRAVGGFYRLNADLTLERLALPPAAIANSIGFSPDGSKMYFCDSLVREIFVCDYRPGGEVANVRPFARLTDPDGDPDGSIVDRDGGLWNAQWGGRRVVRYGPDGVETDRVAVPTAQPSCTALDGEGRLYVTSARVGLSDDALADDPHAGGVFVAQTRHAGMATARFAGTPRG", "function": "Catalyzes the cleavage of L-arabino-gamma-lactone to L-arabonate. Is involved in a degradation pathway of L-arabinose that allows A.brasilense to grow on L-arabinose as a sole carbon source. Can also use D-galactono-1,4-lactone as substrate in vitro; however, the enzyme is probably not involved in the metabolism of D-galactose in vivo.", "AFDB_id": "AF-Q1JUP5-F1-model_v4" }, { "swissprot_id": "Q075Z2", "sequence": "MGSLMLLFVETTRNSSACIFPVILNELSSTVETITHFPEVTDGECVFPFHYKNGTYYDCIKSKARHKWCSLNKTYEGYWKFCSAEDFANCVFPFWYRRLIYWECTDDGEAFGKKWCSLTKNFNKDRIWKYCE", "function": "Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.", "AFDB_id": "AF-Q075Z2-F1-model_v4" }, { "swissprot_id": "Q1DNB0", "sequence": "MSASPDYKTNLLSHLISNKVLSFGSYTLKSGRNSPYFFTTTLLHTAPLLHATASACASVLSSPPFVTTSTPDGTPRPNFDIIFGPAYKGIPLCTAVLNELGVRDTTGAWNNISYSFNRKEAKAHGEGGNIVGAPLKGKKIVIIDDVITAGTALREAVGIIEKEGGTVVGVLVLLDREERVNDNEKKSAVGCAQRDLGENVPVKAVLSLSDIIEKLGNDIGEENLKRLKEYRAQYGAEE", "function": "Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).", "AFDB_id": "AF-Q1DNB0-F1-model_v4" }, { "swissprot_id": "Q59066", "sequence": "MGNCNEYTALKIGALLHDIGKFIQRASDKPKSKGHDKFGYEFLKEKFKNGFLNHLDEKTKDKILEIVKEHHNQKIKDDLIGIVRLADWLSSGERREPKGDPENVEVLNTEEQKLLSIFETVCIGELTENLYKNGFKYSLKPLNVSDAIFTDKPYPNENYKELFSKFEDEIKDFKGDVSFEELYQLMQKYTWCIPSVTMWKKAGSLKGGLPDVSLFDHSKTTCAIACCLYQMYVKENKKKNKYAKEYIDDKTLEKLFNNDNGWNKEIFSLIHGDLSGIQDFVFTITTKYATKSLKGRSFYLDFLTEYFAKYICKELNLPITNILFYGGGHFYILSYKVDENLINKLEKEINEVLFNMFRTKIYITIAEVGVTPNDFKKSEDKESKEKTWGFAKKWKEVSEKTVEKKLRRFEYKLEGLFEPYNRGSENRCVICRNEFDKNEKGYAIRENESKSERICDYCASFVALTDILKNFQMEKTIKFNKAYPIIHLTKNKDNLSLQREEFSFLTVKAIEKLESKFRVLSDENYFLKEYKLPHDSGELIIPYKIWAIAFPIIENETEKRILDFDGLAEKAFERTGTRKIGILKMDVDNLGEIFTTGLGNDATISRMSTLSSMLTLFFTGYIPHLIKNEEFEVNGKKYKFKDNIYLVYAGGDDTLIVGAWDAVWELAKRIRGDFKKFVCYNPYITLSAGIVFVNPKFEFKKAVNMAEEELENGKNYIIYEDEETEKKVDKNALTVFNCPMNWDLEVEYNEYCWTKLKSYLEGINKEMVELESLVKKFNEDDLEKNLKKQLKRQIRKESYI", "function": "When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csx1, inducing an antiviral state important for defense against invading nucleic acids.", "AFDB_id": "AF-Q59066-F1-model_v4" }, { "swissprot_id": "Q5XI63", "sequence": "MRGRGSRDTGTQSAAFASRPVRTTVDMQAQRAPLMEVKRNLELSTTLVKSSSRLPLPGSRLKRGPDQMEDGLEPAKKRTRGMGTVTKVDTSRPRGPPLSAVSTAAQKGPRKTGPRGCSAVGPVLRNQKPAPAAPAQKPGTSTAPAVAGKKPGKRPAWDLKGQLCDLHEELKQYREKTQTLDRENQGLREQLREVQEQATTLGTERNTLEEELASVRRRAEQSQQKLETLGARVLELEECLGTKERLVQELQTERLQLQEERSTLSTQLEEREREFQASEAALSSSRAEVLCLRQKTAAQVTLLAEQGDRLYGLEMERRRLHNQLQELKGNIRVFCRVRPVLEGESTPSPGFLVFPPGPAGPSDPPTRLCLSRSDDRRSTLTRAPAAATRHDFSFDRVFPPGSKQEEVFEEISMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDPQLEGLIPRAMRHLFSVAQEMSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGDCEIRRAGPGSEELTVTNARYVPVSCEKEVEALLHLAQQNRAVARTAQNERSSRSHSVFQLQISGEHAARGLQCGAPLNLVDLAGSERLDPGLTLGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANKK", "function": "Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure.", "AFDB_id": "AF-Q5XI63-F1-model_v4" }, { "swissprot_id": "P23146", "sequence": "MKFGNFLLTYQPPQFSQTEVMKWLVKLGRISEECGFDTVWLLEHHFTEFGLLGNPYVAAAYLLGATKKLNVGTAAIVLPTAHPVRQLEEVNLLDQMSKGRFRFGICRGLYNKDFRVFGTDMNNSRALMECWYKLIRNGMTEGYMEADNEHIKFHKVKVLPTAYSQGGAPIYVVAESASTTEWAAQHGLPMILSWIINTNDKKAQIELYNEVAQEYGHDIHNIDHCLSYITSVDHDSMKAKEICRNFLGHWYDSYVNATTIFDDSDKTKGYDFNKGQWRDFVLKGHKNTNRRVDYSYEINPVGTPQECIDIIQTDIDATGISNICCGFEANGTVDEIISSMKLFQSDVMPFLKEKQQFSYYIS", "function": "Light-emitting reaction in luminous bacteria.", "AFDB_id": "AF-P23146-F1-model_v4" }, { "swissprot_id": "P42114", "sequence": "MPITPTKYAITTRQSANWSDAKRRVFALYRRWLRSTPEMQSMYSLPLPISVIRTRIRQEFERNRFVNKLPVVDVLLTKGHADYQETMNFWRQTTHMMSYFNEESFRGAKRLPSSFIDGFLQGRN", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The precise function of this subunit is unknown but believed to be important.", "AFDB_id": "AF-P42114-F1-model_v4" }, { "swissprot_id": "G8JZS4", "sequence": "MKKRKILSLIAFLCISFIANAQQKLTSPDNNLVMTFQVDSKGAPTYELTYKNKVVIKPSTLGLELKKEDNTRTDFDWVDRRDLTKLDSKTNLYDGFEVKDTQTATFDETWQPVWGEEKEIRNHYNELAVTLYQPMNDRSIVIRFRLFNDGLGFRYEFPQQKSLNYFVIKEEHSQFGMNGDHIAFWIPGDYDTQEYDYTISRLSEIRGLMKEAITPNSSQTPFSQTGVQTALMMKTDDGLYINLHEAALVDYSCMHLNLDDKNMVFESWLTPDAKGDKGYMQTPCNTPWRTIIVSDDARNILASRITLNLNEPCKIADAASWVKPVKYIGVWWDMITGKGSWAYTDELTSVKLGETDYSKTKPNGKHSANTANVKRYIDFAAAHGFDAVLVEGWNEGWEDWFGNSKDYVFDFVTPYPDFDVKEIHRYAARKGIKMMMHHETSASVRNYERHMDKAYQFMADNGYNSVKSGYVGNIIPRGEHHYGQWMNNHYLYAVKKAADYKIMVNAHEATRPTGICRTYPNLIGNESARGTEYESFGGNKVYHTTILPFTRLVGGPMDYTPGIFETHCNKMNPANNSQVRSTIARQLALYVTMYSPLQMAADIPENYERFMDAFQFIKDVALDWDETNYLEAEPGEYITIARKAKDTDDWYVGCTAGENGHTSKLVFDFLTPGKQYIATVYADAKDADWKENPQAYTIKKGILTNKSKLNLHAANGGGYAISIKEVKDKSEAKGLKRL", "function": "Glucoamylase that hydrolyzes alpha-1,4-glucosidic linkages, alpha-1,6-, alpha-1,3- and alpha-1,2-glucosidic linkages during starch degradation.", "AFDB_id": "AF-G8JZS4-F1-model_v4" }, { "swissprot_id": "Q2QX01", "sequence": "MATSSAAAALRLPASQLPLSARPSSSSTLRFPPRRPARRGGLAVSAFTKLSEASPVAIPPEPAQPLPDEEALPPKPGVYGVYDPAGELQFVGISRNVRASVEGHRRKVPADLCGSVKVSIADEETPDRTVLTNAWKSWLEEHITATGKAPPGNVAGNHTWVGPPQRPPDLRLTPGRHVQLTVPLEQLIDRLVKDNKVVAFIKGSRSAPQCGFSQRVVGILESHGVDFVTVDVLDEEHNHGLRETLKTYSNWPTFPQVFVGGELVGGCDIVSSMAEKGELAALFKK", "function": "May only reduce GSH-thiol disulfides, but not protein disulfides.", "AFDB_id": "AF-Q2QX01-F1-model_v4" }, { "swissprot_id": "Q59LQ5", "sequence": "MAGDLNLKKSWNPALVKNQQKVWEEEQQKLDELKRIKERNQEYKQEQEYLELLKLQHGDQFQIKDLNKQQKLKISKLNWMYDDVPFEGNEKVEENSSGFIESNVEFTDGKSKVENLLKGNHVVGKKRDGSGTSDRINKIIGVGMTKSSKVSYSDDPLLKIKQQQQQAQRVARKQHPSDKHSHRSRHSSKSSSDRVHKSHEHERSRKHNSSHTRHKDGSPHR", "function": "Involved in pre-mRNA splicing.", "AFDB_id": "AF-Q59LQ5-F1-model_v4" }, { "swissprot_id": "Q8RD30", "sequence": "MDRLLRIYNKEERLVVGLMSGTSADGIDAALVKVKGRGLDTKVELLEFEKFPYEEEVQKKIFELFDPHTGTVEKICHMNFLLGELFAEATLKLIKKAGLTPKDIDLIGSHGQTIYHIPNFIEDMGYKVRSTLQIGEPAVIAERTGIVTVADFRVRDVAAGGQGAPLVPYTEYILYRSPNETIALQNIGGIGNVTVLPKGGSIEDVIAFDTGPGNMVIDEVVKRITHGKMNFDKDGELASRGKVNEEFLAELLKDEFFKMKPPKTTGREHFGKNYVDNLMKKASYLEIDKYDLVATVTALTAYSVVRSYEKFIFPYYKVDKVVIGGGGSFNKTLVQMIKKQLPQVRVITQEDIGFNSDAKEAVAFAILASETINGNFNNIPKATGAKHPVVMGKISL", "function": "Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.", "AFDB_id": "AF-Q8RD30-F1-model_v4" }, { "swissprot_id": "P22059", "sequence": "MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGPGAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSSCPDIF", "function": "Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.", "AFDB_id": "AF-P22059-F1-model_v4" }, { "swissprot_id": "P73651", "sequence": "MVLRQVMDFAQAVEHLLHPAVVSFNPHPRSFFSGRTQPLLTPLPEKAAQLTAIGIEQLVLLPFTEKLANLSPKQFVQSILVEQLQAKFISVGQDFCFGHQRRGNVQDLQNLGQEFGITVAIAQLEQTDTERISSSRIRRALKEGKLAMANHLLGRPYALRGTVVQGQQLGRKLGFPTANLCLPADKLWPKYGVYAGWVNLNALDVPIPAVINLGDRPTVNGQEPSAEVHLLQWSGDLYGQGLEVALTHYLRPETKFAGLDQLKNQIAQDCQQAEKLLNLDGAIP", "function": "Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.", "AFDB_id": "AF-P73651-F1-model_v4" }, { "swissprot_id": "A2CBR5", "sequence": "MATTLRDILDKLLGRQPASAKTARERLQLVLAHDRSDLSPELLDQMRREIFEVVAKYVEIDIEGGDVSLETEDRMTALVANLPIKRSQAKAVSNQAKAVSNQEKAVSSQEKVSNSQESVSTPEAME", "function": "Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.", "AFDB_id": "AF-A2CBR5-F1-model_v4" }, { "swissprot_id": "Q8CHI5", "sequence": "MSGPLEGADGGGDPRPGEPFCPGGVPSPGAPQHRPCPGPSLADDTDANSNGSSGNESNGHESRGASQRSSHSSSSGNGKDSALLETTESSKSTNSQSPSPPSSSIAYSLLSASSEQDNPSTSGCSSEQSARARTQKELMTALRELKLRLPPERRGKGRSGTLATLQYALACVKQVQANQEYYQQWSLEEGEPCAMDMSTYTLEELEHITSEYTLRNQDTFSVAVSFLTGRIVYISEQAGVLLRCKRDVFRGARFSELLAPQDVGVFYGSTTPSRLPTWGTGTSAGSGLKDFTQEKSVFCRIRGGPDRDPGPRYQPFRLTPYVTKIRVSDGAPAQPCCLLIAERIHSGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVHPWSRKVAFVLGRHKVRTAPLNEDVFTPPVPSPAPSLDSDIQELSEQIHRLLLQPVHSSSTTGLCGVGPLMSPGPLHSPGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLFIESRAKPPPRPRLLATGTFKAKVLPCQSPNPELEVAPAPDQASLALAPEEPERKESSGCSYQQINCLDSILRYLESCNIPNTTKRKCASSSCTASSASDDDKQRAGPVPVGAKKDTSSAVLSGEGATPRKEPVVGGTLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESDIIMMEDLPGLAPGPAPSPAPSPTVAPDPAPDAYRPVGLTKAVLSLHTQKEEQAFLSRFRDLGRLRGLDTSSVAPSAPGCHHGPIPSGRRHHCRSKAKRSRHHQTPRPETPCYVSHPSPVPSSGPWPPPPATTPFPAVVQPYPLPVFSPRGGPQPLPPAPTSVSPATFPSPLVTPMVALVLPNYLFPSPTSYPYGVSQAPVEGPPTPASHSPSPSLPPPPPSPPHRPDSPLFNSRCSSPLQLNLLQLEESPRTEGGAAAGGPGSSAGPLPPSEESAEPEPRLVEVTESSNQDALSGSSDLLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSASITRSSQSSHTSKYFGSIDSSEAEAGAAQARTEPGDQVIKYVLQDPIWLLMANADQHVMMTYQVPSRDAASVLKQDRERLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPQALDVTACVDCGSSVQDPGHSDDPLFSELDGLGLEPMEEGGGEGGGVGGGGGGVGGGGGDGGEEAQTQIGTKGSSSQDSAMEEEEQGGSSSSPALPAEENGTS", "function": "Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.", "AFDB_id": "AF-Q8CHI5-F1-model_v4" }, { "swissprot_id": "Q05B66", "sequence": "MVVGAFPMAKLLYLGIRQVSKPLANRIKEAARRSEFFKTYICLPPAQLYHWVEMRAKMRLMGFNAETIKPLNEEAAAELGAELLGEATIFLVACGCLVLEYSRQKTQQRRKEGEQLAAWDAMRDEVDHLALVLEALQAQVQAAPPPGALEELQAQMREVRAQLCVQDLPPAPQEEPTPRDEGPPDPGLGQD", "function": "May play some role in mitochondrial processes.", "AFDB_id": "AF-Q05B66-F1-model_v4" }, { "swissprot_id": "Q8ZYL6", "sequence": "MSVRALFPKGKEPRYAFEVLIRMLPEAVLNFSSDGISLKALDPTKTALLDLTFYATALEDYSIDEETKVGIIFTTIKDVIKRIGATEKLELEVDKERNRFSFYIYPKKGREVGLVRRFSFPIVQVLEEEIPELAVSFDASFEIDSAVLDDILAMVDEVSDWIQITVSPDKVLFRGVGEGGKAAETELSYDSESVFNISAGEAASAKYSVEMLRDISGKMKSLSKRVKVELSANKPIRLTYEFTSGVFTATIAPRVD", "function": "Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.", "AFDB_id": "AF-Q8ZYL6-F1-model_v4" }, { "swissprot_id": "Q0S032", "sequence": "MTSDIVVIGGGVAGVTAAQSLRSEGYDGRLVLIGKERELPYDRTALSKAVLAGDLADPPLLFPADWYDEWQIETVLDRTVLQVDVTRREVLLDGGPWLKVDRVLLATGASARVPSFSGSDLPGVATLRTADDVHRMRRDWEPGQRLVVVGGGLIGCEVATTARKLGLEVSILEASDELLQRVLGRRIGGWCRARLMELGISVVLNTGVAEFKGVDRITTVIGTDGRSFVADRAIVCVGAEPETAIAEQSGLACNRGILVNDSGGTAAEGVFAAGDVASWPLLTGGRRSLETYINSQREATAVASAMLGKAVHGPQLPLSWTEMAGHRIQMIGDIEGSGEYVMRGDPDDGPALLFRLSDGRVTAAVSVDAPRDFAMATRLVERGAQVGREVLGDTSMELRELNRAARERALIAE", "function": "Ferredoxin reductase component of the biphenyl dioxygenase system that catalyzes the stereospecific dihydroxylation of the aromatic ring of biphenyl, yielding a dihydrodiol compound. Is likely involved in biphenyl degradation that allows growth of Rhodococcus sp. strain RHA1 on biphenyl as the sole source of carbon and energy. The dioxygenase system can also use naphtalene and 4-chlorobiphenyl (4-CB) as substrates, as well as some polychlorinated biphenyls (PCB) such as 2,2'-dichlorobiphenyl, 2,3-dichlorobiphenyl and 2,5,2'-trichlorobiphenyl. It exhibits weak activity toward dibenzofuran and dibenzo-p-dioxin. Electrons are transferred from NADH to the [2Fe-2S] cluster in BphA1 via FAD of BphA4 and [2Fe-2S] cluster of BphA3.", "AFDB_id": "AF-Q0S032-F1-model_v4" }, { "swissprot_id": "Q9HLB8", "sequence": "MKSALLLLSYGSPERIEDLDEYLKNIFNGKPVPESVREENLRKYEMFGGRSPSNRIIESIARKLHEKIGDDMDVILAYKHWNPSIEEAVKGLGSYDNIVAIPLFSFYSQNVKDSYLNPLESALRRYGFSPRLEFVNGLANSDLFLPMWANIISEDASEDSFYLFDAHSLPAPDREEDYLFWLRYSTYKISQILGLSRSDFGFQGGHLGWLGPSIYDVLNRIDASKITVIPISFLYDHLEILYDLDYEFRKAVEAKGMHYRRVRMPNDSAMMVNMIERAARSAITHLSGEKINGSIIGQPRIADTDNGR", "function": "Catalyzes the ferrous insertion into protoporphyrin IX.", "AFDB_id": "AF-Q9HLB8-F1-model_v4" }, { "swissprot_id": "Q27441", "sequence": "MQRVILVVLLLSCMAVLSVRADNSEMLAPPPRPEEFTSAQQLRQYLAALNEYYSIMGRPRFGKRGDSFRKREFFRTNGERYPEDAAAWTEFQ", "function": "May play a role in the regulation of viscermotor functions during egg laying.", "AFDB_id": "AF-Q27441-F1-model_v4" }, { "swissprot_id": "O13749", "sequence": "MNAPSFTGLPTSMLSVKMICSECREDPPNLVEEFSSGDTVCGSCGLVLGDRIIDTRSEWRTFSNSDEASGDPSRVGKVANPLLNGSQLDTTISSYDGAGAMLAKAQGRSVQVRGEKNLLTAYKEIGAMCDAISLPKVIADTAKQLYKRVDDHKALKGKSSQSIIAACIYIACRQGKVPRTFMEICTLTNVPKKEIGRVYKTLQRMLTEGGALHNSVDALKGHEYIQSSSTSAEDLMVRFCNRLMLPMSVQSAAAELARRAGLQGTLAGRSPISIAASGIYMISALMGYPKTPKEISEVTGVSDSTIRIAYKLLHAERKELIDPKWIANKAGNMDAMLPKP", "function": "General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.", "AFDB_id": "AF-O13749-F1-model_v4" }, { "swissprot_id": "Q76NT9", "sequence": "MEIDIEKLPIIDISSFQNNENDKNQVAKEINKACKEYGFFYIKNHGVDQELIENLQNVIKKFFSLPLEIKMKWKMGLTNREWLGFFKVGQEITYGQVDWKEGCYYSSEMDGDINTIHNVPLYPTAEQEEQYEIQGFKSTIHTYIEKLTHLSQQIIEAISLSLNLPQDYFFKNYTYDPFILMGLLHYPSFHHQEQEEEQEDDESNNGGKKSPNPDESKKPEVEKFGTGQHTDWGLLTVLYQDDVGGLQVKSKNSEEYIDAPPIPGTFICNIGDMLDKMTGGYYLSNLHRVKYNKSGRDRFSIPFFLDPSLNSIPKLIPNYDQLSQFADKPERWDKQNIHEFDGTYGQYFIKKIGRVFPDYVYKKSGELV", "function": "Involved in ethylene biosynthesis. Overexpression induces overproduction of ethylene.", "AFDB_id": "AF-Q76NT9-F1-model_v4" }, { "swissprot_id": "Q6CK18", "sequence": "MDASGVIDELKHRKEAFVTGHSGSSIADLRDVTLAGIFSNAAWIYVVSNNPSYRDSFWLDFLLNWMGLLCSVTVFGENPFLTGILGLSAVLLFGCISKGSKRETIKETVMDNGNQSATLTVYRSTMLILTSIAILAVDFPIFPRKYAKVETWGISLMDLGVGSFVFSNGIISYKRLKSGTELSKWAKIKQSLRSTVVLVVLGFIRLFSVKAVNYQEHATEYGIHWNFFFTLSLLPLAMIIFDFYNMRLRFVIGLIAAIIYELCLIYHPTFLDYLLNAERIDFISANREGIFSFVGYCIIYLAGQQVGSMFFPISRNPMQLLWKLVALSIFSSAISYVLLHYHPLQVSRRFASIGYSSMVISFNLLILTFDQLIVECLTSKPRVPKTYRAVNGNGMLVFLISNVTTGMVNFTFNTLDSPPYKAMAILTVYALFLAVFALKVPFKLKF", "function": "Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.", "AFDB_id": "AF-Q6CK18-F1-model_v4" }, { "swissprot_id": "Q54C29", "sequence": "MTLSKVFQYLASLDSKDLEELYKDPWTCQAILRSLPPRSKQYILKMLLVDTYPLSLAKDWSTQASIQQHKESLKKLFDLKIIFLDKINKPIQPQQQQSSQQSSSQQQQQQQQQQQQTEQTIRLNPLFQDNIKRSLVQVNQVIFSNNSSIKDNHKPPSIDDLDSYSKSQWEKVLYFLSDDTVQPSKLISELLLSSNLTKQEGDGLSITSEGFKFLLKDVYTQIWTLLIVYLDDLEKKKGKGSGSRNDLLSFLFRLSFLNLGRGYLVSELSEQQKEYLFALKQFGLIYMRTDSSILFYPTRLIISLTTGKTLSLIQSISSERTQTQKEQGYIVLETNYRLYAYTSSSLQISLLSLFVKMLYRLPNLAVGIITRESIRTALIHGITADQIIDFVRHNSHPNAANSGQPIPDVVAEQILLWEAERNRITYTKSVLYNSFPTNDCYIATLKFAKEQDYYIWSHDPLKTLVVKEEGNDPIRNFIKKNFA", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.", "AFDB_id": "AF-Q54C29-F1-model_v4" }, { "swissprot_id": "Q945S8", "sequence": "MPASKKISDRNHLGQVFDKLLNQIGESEEFELPEWLNKGKPTPYIFIRRNIYLTKKVKRRVEDDGIFCSCSSSSPGSSSTVCGSNCHCGMLFSSCSSSCKCGSECNNKPFQQRHVKKMKLIQTEKCGSGIVAEEEIEAGEFIIEYVGEVIDDKTCEERLWKMKHRGETNFYLCEITRDMVIDATHKGNKSRYINHSCNPNTQMQKWIIDGETRIGIFATRGIKKGEHLTYDYQFVQFGADQDCHCGAVGCRRKLGVKPSKPKIASDEAFNLVAHELAQTLPKVHQNGLVNRHIDAGKSWNNLSQRDTCSRNCIGVVIRLSRPTSDRCFGLVRHFDEYSRKHSVMFEDGVTEFVDMSREDWEIV", "function": "Histone methyltransferase.", "AFDB_id": "AF-Q945S8-F1-model_v4" }, { "swissprot_id": "Q9NHD5", "sequence": "MTRSSIELGDVTPHNIKQLKKLNTVVFPVSYNDKFYVDVLEAGELAKLAYYNDIVVGAVCCRIDNTENQRRLYIMTLGCLSPYRRLGIGTVMFEHIMNFAEKDGNFDSIFLHVQINNNGAIEFYKKFGFEIVDTKEQYYKRIEPADAHVLQKTLRRTAPNSNSTATSTTANSNSRSKARQFTFV", "function": "(Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body.", "AFDB_id": "AF-Q9NHD5-F1-model_v4" }, { "swissprot_id": "Q8ENF3", "sequence": "MVSRTERKQHKKRRKWPFWLGGILLVLLLLISGGIFLIYNQVGAVVDTMHSPLSRDSDPDRQKEINQLYKEKDAVNILLLGVDERDGDLGRSDTMILLSINPNTDKMIMLSIPRDTYVNIPGRGMDKINHAYPFGIVDGVGGPDLSVQTVEETFNLSIHSYIRVNMEGFQQGIDAVGGVTVNNAQAFSTGGYNFDQGQITLDGKQALEFIRMRKQDSRGDLGRNDRQRQVIQAAMNEAASFSSITKAGEILDILGNNVQTDLDMDKLQTLLTNYAGARNNITTMEIEGHGETINGIWYYIVSDEEINRVNSEITGHMQEQ", "function": "May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG).", "AFDB_id": "AF-Q8ENF3-F1-model_v4" }, { "swissprot_id": "Q3JE53", "sequence": "MSATLDAPSPSKPRIVLGFDFGLRYIGVAVGQEVTHSANPLTTLKAHEGNPDWNQITQLIRQWNPDLLIVGLPLNMDQSEQFLTKAARRFGHRLHGRYGLAVEWVDERLSTVEARERLNIKSSASGRRQGIDQMAAQCILQTWLTEQQTIRH", "function": "Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.", "AFDB_id": "AF-Q3JE53-F1-model_v4" }, { "swissprot_id": "Q71EW5", "sequence": "MASKKHVVCQSCDINCVVEAEVKADGKIQTKSISEPHPTTPPNSICMKSVNADTIRTHKDRVLYPLKNVGSKRGEQRWERISWDQALDEIAEKLKKIIAKYGPESLGVSQTEINQQSEYGTLRRFMNLLGSPNWTSAMYMCIGNTAGVHRVTHGSYSFASFADSNCLLFIGKNLSNHNWVSQFNDLKAALKRGCKLIVLDPRRTKVAEMADIWLPLRYGTDAALFLGMINVIINEQLYDKEFVENWCVGFEELKERVQEYPLDKVAEITGCDAGEIRKAAVMFATESPASIPWAVSTDMQKNSCSAIRAQCILRAIVGSFVNGAEILGAPHSDLVPISKIQMHEALPEEKKKLQLGTETYPFLTYTGMSALEEPSERVYGVKYFHNMGAFMANPTALFTAMATEKPYPVKAFFALASNALMGYANQQNALKGLMNQDLVVCYDQFMTPTAQLADYVLPGDHWLERPVVQPNWEGIPFGNTSQQVVEPAGEAKDEYYFIRELAVRMGLEEHFPWKDRLELINYRISPTGMEWEEYQKQYTYMSKLPDYFGPEGVGVATPSGKVELYSSVFEKLGYDPLPYYHEPLQTEISDPELAKEYPLILFAGLREDSNFQSCYHQPGILRDAEPDPVALLHPKTAQSLGLPSGEWIWVETTHGRLKLLLKHDGAQPEGTIRIPHGRWCPEQEGGPETGFSGAMLHNDAMVLSDDDWNLDPEQGLPNLRGGILAKAYKC", "function": "Catalyzes the hydration of acetylene to form acetaldehyde. Ethylene cannot act as a substrate.", "AFDB_id": "AF-Q71EW5-F1-model_v4" }, { "swissprot_id": "Q9R9J2", "sequence": "MNNLAFLFPGQGSQFVGMGKSFWNDFVLAKRLFEEASDAISMDVKKLCFDGDMTELTRTMNAQPAILTVSVIAYQVYMQEIGIKPHFLAGHSLGEYSALVCAGVLSFQEAVKLIRQRGILMQNADPEQLGTMAAITQVYIQPLQDLCTEISTEDFPVGVACMNSDQQHVISGHRQAVEFVIKKAERMGANHTYLNVSAPFHSSMMRSASEQFQTALNQYSFRDAEWPIISNVTAIPYNNGHSVREHLQTHMTMPVRWAESMHYLLLHGVTEVIEMGPKNVLVGLLKKITNHIAAYPLGQTSDLHLLSDSAERNENIVNLRKKQLNKMMIQSIIARNYNKDAKTYSNLTTPLFPQIQLLKERVERKEVELSAEELEHSIHLCQLICEAKQLPTWEQLRILK", "function": "Is involved in the mycosubtilin synthetase assembly, by catalyzing the transfer of malonyl groups to a specific acyl-carrier-protein domain on MycA.", "AFDB_id": "AF-Q9R9J2-F1-model_v4" }, { "swissprot_id": "P52967", "sequence": "MAKIGLFFGSDTGTTRKIAKQIKDMFDDEVMAKPLNVNRADVADFMAYDFLILGTPTLGDGQLPGLSANAASESWEEFLPRIADQDFSGKTIALFGLGDQVTYPLEFVNALFFLHEFFSDRGAKLVGRWPAKGYGFEDSLAVVEGEFLGLALDQDNQAALTPERLKGWLSLIAADFGLVLPA", "function": "Low-potential electron donor to a number of redox enzymes. NifF is the electron donor to nitrogenase.", "AFDB_id": "AF-P52967-F1-model_v4" }, { "swissprot_id": "C1A8P2", "sequence": "MANLKYRILLIAALFAASVFALFPRTVVERVKREGVFVYDTVRRVPLKRGLDLQGGMHLTLEVDESKQTVADKSEALDRALKVVRQRIDEFGVAEPVVQKAGSERLIVELPGIDDAERAQDVVQKSAFLEFQITDKTQALEKVVPRFDEIAKTQGITVASGTAAAAGDSAKSTSVNSLLTQNADSAKDSTAAAGTTGADTTIKAPVVTGGLFSTNVQPGQMPGQYIVPESAFPAIERALQHPAILAAVPPGKVIRWGVDSLVSGAARFRALYVLDARPIITGEVLTDARPATDPVEGNVVQFTLNNEGARRFKTETGKHVRDNMAIVLDQRVVTAPTLNSAIGRNGQITLGGGTLQSAQDLALVLRAGALPVPLKVAEVRQIGASLGSDSISKGVMALGVALLLVLVIMVVYYRFSGVLAVIALVLYLVYTLAILAGFNAVVTLPGLAGFVLSIGMAVDNNVLIFERIREELDHGKSTRLAIDEGFRHALGAIIDTSAATILSGMVLYQYGTGPVRGFAVTLIAGLVAALFTTIFVTKTFFLVWLNRSRGTQTLSI", "function": "Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.", "AFDB_id": "AF-C1A8P2-F1-model_v4" }, { "swissprot_id": "Q62840", "sequence": "MSASKIPLFKMKGLLLFLSLVKMSLAVPAFPQQPGAQGMAPPGMASLSLETMRQLGSLQGLNALSQYSRLGFGKALNSLWLHGLLPPHNSFPWIGPREHETQQYEYSLPVHPPPLPSQPSLQPHQPGLKPFLQPTAATGVQVTPQKPGPHPPMHPGQLPLQEGELIAPDEPQVAPSENPPTPEVPIMDFADPQFPTVFQIAHSLSRGPMAHNKVPTFYPGMFYMSYGANQLNAPARIGFMSSEEMPGERGSPMAYGTLFPGYGGFRQTLRGLNQNSPKGGDFTVEVDSPVSVTKGPEKGEGPEGSPLQEASPDKGENPALLSQMAPGAHAGLLAFPNDHIPNMARGPAGQRLLGVTPAAADPLITPELAEVYETYGADVTTPLGDGEATMDITMSPDTQQPPMPGNKVHQPQVHNAWRFQEP", "function": "Involved in the mineralization and structural organization of enamel.", "AFDB_id": "AF-Q62840-F1-model_v4" }, { "swissprot_id": "Q9SUS1", "sequence": "MDEGDLEAIVRGYSGSGDAFSGESSGTFSPSFCLPMETSSFYEPEMETSGLDELGELYKPFYPFSTQTILTSSVSLPEDSKPFRDDKKQRSHGCLLSNGSRADHIRISESKSKKSKKNQQKRVVEQVKEENLLSDAWAWRKYGQKPIKGSPYPRSYYRCSSSKGCLARKQVERNPQNPEKFTITYTNEHNHELPTRRNSLAGSTRAKTSQPKPTLTKKSEKEVVSSPTSNPMIPSADESSVAVQEMSVAETSTHQAAGAIEGRRLSNGLPSDLMSGSGTFPSFTGDFDELLNSQEFFSGYLWNY", "function": "Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Activates WRKY 22, SIRK and its own promoters.", "AFDB_id": "AF-Q9SUS1-F1-model_v4" }, { "swissprot_id": "Q47157", "sequence": "MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRTNDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF", "function": "Toxic component of a type II toxin-antitoxin (TA) system. A translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome; YafO alone is not able to digest mRNA.", "AFDB_id": "AF-Q47157-F1-model_v4" }, { "swissprot_id": "Q12068", "sequence": "MSVFVSGANGFIAQHIVDLLLKEDYKVIGSARSQEKAENLTEAFGNNPKFSMEVVPDISKLDAFDHVFQKHGKDIKIVLHTASPFCFDITDSERDLLIPAVNGVKGILHSIKKYAADSVERVVLTSSYAAVFDMAKENDKSLTFNEESWNPATWESCQSDPVNAYCGSKKFAEKAAWEFLEENRDSVKFELTAVNPVYVFGPQMFDKDVKKHLNTSCELVNSLMHLSPEDKIPELFGGYIDVRDVAKAHLVAFQKRETIGQRLIVSEARFTMQDVLDILNEDFPVLKGNIPVGKPGSGATHNTLGATLDNKKSKKLLGFKFRNLKETIDDTASQILKFEGRI", "function": "Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG, 2-oxopropanal) to (S)-lactaldehyde as an alternative to detoxification of MG by glyoxalase I GLO1. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation. Also catalyzes the reduction of 3-methylbutanal to 3-methylbutanol. Acts as a suppressor of 3-methylbutanol-induced filamentation by modulating the levels of 3-methylbutanal, the signal to which cells respond by filamentation. Also involved in ergosterol metabolism.", "AFDB_id": "AF-Q12068-F1-model_v4" }, { "swissprot_id": "P39695", "sequence": "MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRHAFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETPDKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHIHWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVEDEVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLTGAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAVSFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFYTFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAPVLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQGDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDALILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRGDVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFPNIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIRVLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN", "function": "The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding.", "AFDB_id": "AF-P39695-F1-model_v4" }, { "swissprot_id": "Q4WAW3", "sequence": "MAMALAVGAPSEQRGNLPYNTLKDGPTVDSMKATTDGKNGQGESAFWDTCVHTVFREHCQRAPNSPAVNAWDGSFTYAELDSLSDAIASVLILSGVGPESIIPIYMQKSRWTTVAILGVLKSGGAFTLLDPSHPRSRVEEISKEIQARFILTSEKLSKQCLEMFSVLVVEHLSRACLPSPGQAGHTRSRPENAAYIAFTSGSTGKPKGIVIEHRSYCSGARSHLKVFGIDSTSRVLQFASYAFDVSIMETLSTLMAGGCLCVMSESERSDPNLFVVSYKNLRISHCFMTPSFARTVPWTECCNPPPTLIVGGELMRPSDARAYKEMGIRCMNAYGPAECSVNVSVQSRVEAAVDPRNIGYTTGATAWIISPENPEELMPTGTVGELLVEGPIVGRGYLNDPKATRQAFIDTPAWLRRHRKGTSYQHRVYRTGDLASLDSITGALLLHGRKDAQVKIRGQRVELPDIEHHLQLTLPNDNAEVIVEKVTFSDDGSEKLIAFVLVRPSNTDSVIGNTGDRLFLAPQSQIMEQFAISKKHLQTHLPSYMVPDIFIPISTLPQTASGKTDRKALRTRAAALSRRDVQCFLLSPAGGKRPPSTPKEATIRSLYSNVLNLPIDLIGMDDTFLRLGGDSLQAIRLVAAARAAGLILQAKDILSSQSTLAEQSKRAGLIQTIDRTWESSPPFALLHGPTRHAIVDLAQKQCRVPSNLIEDIYPCTALQEGMFITSLKHPGMYTGQIIFDIPDRMELPRLRAAWLSVVSENAALRTRIIETHEGLMQAVIVDDFVWEEETDEMLLSSDGEALEITKIGVPLVRFRYRPRHRQLMMTIHHSIWDGWSLRLVHEQLHRAYIGRDLLPSTSYRSFIQYTQELQGADEFWASELAGVNAPIFPTLPSGNYRPRVNASHRHVVRNLASTGKEEHTAATYIHLAWSLLVAHYTDADETVYGVTVNGRSADVPGVENIVGPTIATVPTRIRVNEEDTVEMALDHVQDALARMIPYEQAGLQRISRCSRDASEACRFQTLLIIEAPTDSDVDCEKNEAGNFSIIGGTTQTGMDYTAFSSYAMMLVFRTSANKSAISFDITYDAQVIGHDEVERMAHQFEHVLRHIYTLATGRIGDISFIGPRDIEQVQQWNSSMPPADNRFLQELIFAQCSRRPQASAIISWDGSWTYRELWAHSSFFARQLQRYGVTRGTPVAVCLDRSRWSIAVILGVLLARGTCVLIDLLAPRQRVRDILQIAGTGILVHSHATATLTSGLCPTVVNVSFLAAQSDSSQPEFPFTLETWGGTPEDLAFIIFTSGSTGHPKGIEMPHRTLSTSISHHSAGMRVTSSSRVLHFSSYAFDVSIYEIFTTLAAGGTICVPSEFDRMNNLAGFIQDTQVNWAFLTPSTARSLNPADVPLLTTLVLGGEAVTHESVEVWAKGRSLINGYGPAEATICGVGNIPEAGWKSGVVGRIIGGLGWVTVPSDPNRLAAVGAVGELLLEGPFLARGYLNLPEVTKAAFIDPPSWRTRIPAPSPYSFLYRTGDLVRYQPDGSIQYVGRKDSRVKLRGQLVDLGAVEASVMRVYPAAGQVVADVLVSENTARLIAMVKLGPSVTENHDGPMFAAPDLVFNEAAASIQARLRAIVPAYMVPSMFIPLRHIPRTLTGKTDRRRLRDKILSLSHSDLQRYMMSSSTKTPMSDDNERRLQEIWAEVLQLPCEAIGREDSFLSLGGESLATMKMVALARRVGFMFAVTDVMNNTSLSTLARSRHLITEQAILTSSPSLSLPTIEGESLQEILRPLLNAGHIQGGNDIAAIHPVTAAQAFLVQRYPWSHFQFDLSGAVSPSKLQTACTALMARFTILRTVFVEHAGCLLQLVLREVPNRVHEITTNEPLDDFCNSVCQQQQDVCVVNSTTLPTLFTLVSNRQLNRHRLLLRLAHAQYDLTTIPLIVQSLADEYNRTLRSGFSADFGYYLSHHKRQNNDDRSHNFWKRYLSGSSMMSTNQTADPTTVQERVFHVTGSCIIIPTSHPPDITIATAVKAAVCLVLAARTGCTDIVIGQTVDARCSSADSTLDQIVGPCTNYIPYRLSVCCSKTALEYLRSAQAQHTTCLRYSSLDFDQIVAKCTSWPSSTQFGYIVQHQDTGAELALTLGGDTTSLPMTSYGRVFPQGEVWIGSTPCSTGLRIDVIALSAVLSQKDAQTMAEEVGAALEKLLGCGYRRLSHLIGNTFAT", "function": "Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities. The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA. Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B. The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively. The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable). FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B. Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties. In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).", "AFDB_id": "AF-Q4WAW3-F1-model_v4" }, { "swissprot_id": "Q03W39", "sequence": "MALGDTIKRLFSNEEDDYYEEDGYEQSQQQEQQTTQQTSSQPRFVRQTTQSQTPAGLNSANSKIALFEPKVYSDSRSIASQILGGEAAIVNFTQIDEAQAKRILDFLGGTIYAVNGEIERIGQSIFLVTPNTFEISGTLTDNLEPNSRY", "function": "Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.", "AFDB_id": "AF-Q03W39-F1-model_v4" }, { "swissprot_id": "Q9HKV7", "sequence": "MNESIVISLGGSVISGDPIDADYMKSFARILEASKYRRVGIVTGGGRTARSYISVLRKLNVNENVLDEIGIYATRMNALSMASLIPGSNPTIPFTVEDAVNLMNTYRFVVMGGTEPGHTTDTVAALLCERSATRTLINVTSVDGVYDMDPHRFANAKRFDRIGYREAIALSTKSSAGAGPNVFMDITALTIAMRSRIRVIVTSRDIDNLEKILKGDRAVSTFIDDDQRS", "function": "Catalyzes the reversible phosphorylation of UMP to UDP.", "AFDB_id": "AF-Q9HKV7-F1-model_v4" }, { "swissprot_id": "Q9VKJ7", "sequence": "MSPNTWVIEMPTQKTRSHPYPRRISPYRPPVLNRDAFSRDAPPMPARNHDHPVFEDIRTILSVLKASGLMPIYEQVSDYEVGPPTKTNEFYSFFVRGVVHALTIFNVYSLFTPISAQLFFSYRETDNVNQWIELLLCILTYTLTVFVCAHNTTSMLRIMNEILQLDEEVRRQFGANLSQNFGFLVKFLVGITACQAYIIVLKIYAVQGEITPTSYILLAFYGIQNGLTATYIVFASALLRIVYIRFHFINQLLNGYTYGQQHRRKEGGARARRQRGDVNPNVNPALMEHFPEDSLFIYRMHNKLLRIYKGINDCCNLILVSFLGYSFYTVTTNCYNLFVQITGKGMVSPNILQWCFAWLCLHVSLLALLSRSCGLTTTEANATSQILARVYAKSKEYQNIIDKFLTKSIKQEVQFTAYGFFAIDNSTLFKIFSAVTTYLVILIQFKQLEDSKVEDPVPEQT", "function": "Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females.", "AFDB_id": "AF-Q9VKJ7-F1-model_v4" }, { "swissprot_id": "Q567G6", "sequence": "MAQECWNKINIPFPSAVSSTRIPFTGSIDLLIDCLLADCEKVLTLLCSEVLQTEIRVLYELLYILNNGFRQHKPFRALKQVEQCVNRLKEMKLQAAVEDLKEVCPNKFQREAGAEAGECDVPSQPMLEWLGLKLLGASSLLARTLERCTKTFLLTRQHLRLGEFIVLNVVITSMLSRLWVFFRGILRALIPMYRRNCELLQKVSQSQPMAYLTDFTLPEDLKDFLCLTYPDLKIEEVTKDLLKGTRGKRKSKFSLLSKLFGDTEQQEEIGEGERDLMPILSAGHYEVSSLDLGAAVSQRRTDYSDVSPYGLGIKAMLQQSSKTTKQKSLEQQMKLDSSSKASLCQKRTSLKKTSSFRNMAALLKELMNWCRSCKFYQEHKRLAFLSLKCGRMESLEAEGVRVEKRLKTFKIKVQKALTLQQTFPPKHSCSLPALLRTRWQNKFFMRHFRTLRRRSAVSRKSSGTVKGSLNQRRKCRPLLQSSNEVESGENVTASVEIEKMDSQTSLQEPNIPKDDIDDIFESFGF", "function": "May play a role in the Notch signaling pathway.", "AFDB_id": "AF-Q567G6-F1-model_v4" }, { "swissprot_id": "A5WGY8", "sequence": "MDKVTPAKLSWREDELGNVVPVSEIFGDVYYSLVDGLNESRYVFLTQNKLPERFEALFSRANSSAASNFSIAELGFGTGLNILATWQLWEHSKQQFHTYFNSQTNLQTSSQDHLKGSRSLTPRLHIISTEKHPLTHADLSRSLESWKHKDTSLVPFVDQLLALYPTLISGCHRLQLAEDVTLDLWLGDACFSLQQLANSYDTLPYGAHIDAWYLDGFAPACNESLWADQIFEQVKRLSKPGTTAATFSSAGVVKRGLMAAGFEIKKTKGFGRKREMLTATKLEPVAVSDDTSDNQGATEYDAKSTLALRSKEQVTLDTHAVTPNEQIAVIGAGVCGLMAAWSLAQRGNAVSLIDKEAPLAGASGNPRALLAPKMTPLAHVAEHLHSISYLYSQRFYRQIDQGEHKIFTPTTTLDLLQKSNVDVHQIAEYPEQMATTLSLDSARDISGLQQQDLTANLYLPQSGLINPKALADKVLTHPNISFKQANIKRITPLQAEAFDDVTEVSEVIEVTADITVQPAKRTKVMLHCESGEVLSVNRVVIAAAFESQSLDARIFEFRKIRGQLSWFEPTTEQLQALPTLPLKYSGYCAPFIPQPGDEAVNSVTPSVPTFLLGASFIRNDLDDEIRLSEHAINHQKLLTALPELSAVLPLPDTEADLYQRWQARVGIRSQTPDYHPLVGAVDEQGLIWTLSGMGSKGYAFAPLCAQVLADMMTAQFVPLPAALLAKLSVHRSSLKKPLS", "function": "Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.", "AFDB_id": "AF-A5WGY8-F1-model_v4" }, { "swissprot_id": "Q1GAN0", "sequence": "MNYKERRQLIYELIQTNKIETQEQLLLLLQAHGANATQATISRDIRALHISKVPDDDGRSYYVKAPSAAVNRERQLKDAIRERVATVTAVQFTVVIQTSMKLTYAPILAGLIDDIDNDDVVGTIAGTDTLLVILKDAEAAASFADWAQAIVKERKIY", "function": "Regulates arginine biosynthesis genes.", "AFDB_id": "AF-Q1GAN0-F1-model_v4" }, { "swissprot_id": "A8JUV0", "sequence": "MTSKKRKTLLDADDDNDNFDEDDSGSDFDDDEDPDQIEVPGGGRDLNTAVTYAQNIRSGVGVAPKGGIPIPISGAKIVVGNNKIKPISLLRINNNNNNIVTSVNNRNNNNIISTNGSSNNNNNSINNNSQIIKTTTVTTTPTTVGATPTVGGVALGGKLTVIPIAGRNVALDNNLSNMPKKLNNMVTAMGSPAARSSGNAGTTGSSQGGAIGSTSSYLNSLTTNELMNLAAYVAAKGSNAPPPPPPSTAANSVRHSPTGGIPNPGGNFFGGSAAASTSASAANFNMAASLLAQMSYAGGASQIRALKVAGNIGGVGNNQKPPPIATTPGSGGPAGGAPGSGVKGNNSMMEAVQKLIAMNPEYLTSGIPNTVFQMFMQSMQRPQATPSPNQPMNPGAMVTSAAAAAAHASAVAYVQQEEDEVDYEEMGVAETYADYWPAKLKLGKKHPDAVVETASLSSVEPCDVYYKLSLPLETINSGHLSALQLESITYASQAHDHLLPDGSRAGFLIGDGAGVGKGRTIAGIIYENYLKGRKKALWISVSNDLKYDAERDLSDIGATRIEVHALNKFKYAKISSDVNNNCKRGVIFSTYSALIGESNNKTGKYRSRFRQLLQWCGEDFEGLIIFDECHKAKNLCPVGSGKPTKTGQTVLELQQKLPKARVVYASATGASEPKNMAYMVRLGLWGQGTAFGNFNDFITAVERRGVGAMEIVAMDMKLRGMYIARQLSFKGVSFKIEEVPLSKEFRKIYDQSVELWVEAMQKFTEAAELIDAESRMKKTMWGQFWSSHQRFFKYLCIAAKVNHAVLVARESIKYGKCVVIGLQSTGEARTLDQLERDDGELTDFVSTAKGVFQSFVERHFPAPDRNRINRILGLYDETPSLSSVADSTSSLSNNSNITTAAGKRKGSNNNDNRSTKIKKKKRSGSWECSDSEDENTDMKRNRKRDGGNSNSDSDEANSDDDLKSDIDDEDEDHDVDSDQRSVASDASSDFNPFFSGSDSDIDPWVNARSKKSKKAQKKSKKKVKKEKTKKEITTSSATDPSGSTAMSATVVAALNAVKNRKSQLSTQDKIQDLLQKKQELKGTVTPVGVNGVKLNYGPPPKDAIERACTMKEELLRKIERLGARLPPNTLDQLIDELGGPDNVAEMTGRRGRVVQTDDGSIQYESRTESDVPLETLNITEKQRFMDGEKDVAIISEAASSGISLQSDRRVFNQRRRVHITLELPWSADRAIQQFGRTHRSNQVNAPEYIFLISDLAGERRFASTVAKRLESLGALTHGDRRATETRDLSQFNIDNKYGRQALETVMRTIMGYESPLVPPPTDYSGEFFKDIAGALVGVGIIVNSESHPGVLSLDKDYNNISKFLNRILGCPVDLQNRLFKYFTDTMTAIIQQAKRGGRFDLGILDLGAAGENVTRVRLIRFVRKHATGVAPTEMHTVRVERGMIWQEAIDKYADLFNENEGFYLSHQLRNQKRTAIMVVILESRNSSSTSSTTDLDSGSKKKKTHSKKEIMCQIYRPNTGLQVRHESLFELEKKYRKVASEEAEPHWTEQYDASVNTCSHAYWNGNCRNVSLGNDCEVGLRQRLYHVLAGSVLSVWGRVEHILNTRSNSKMQVIRMKTTEGEKIVGTLIPKSCFEPLVADLRSDSEKQEEFNY", "function": "Notch pathway component, may contribute to the specificity between lateral and inductive Notch signaling pathways in the wing disk. Required during many developmental stages including oogenesis, embryogenesis and imaginal development of the eye, wing and leg. Ebi and sno regulate EGFR-dependent Delta transcription in the developing eye, by antagonizing a repressor function of Suppressor of Hairless (Su(H)). They are required in the R-cells for normal cone cell development.", "AFDB_id": "AF-A8JUV0-F1-model_v4" }, { "swissprot_id": "A0A0E3D8K9", "sequence": "MTVMVSRIEYIGQIVRGEATVIWILVALVLVAYLILPNPTYRTNVKVPTVRYLGGWMPDLVDRLFFNTKATSVIYDGYKQYKKKAYKVLKADGDLVVLSTRYAEELRQLPASTLNALEATFTDHVGDYTTILTDSHLHTETIQKRLTPAIGRLIPRIISELDHAYEVEFPKCDGKWVAINPYEVFLRLVARVGARIFIGDTLCRDEQWLKASIDYTKNIFVTIALLRPVPGFLQPLVGRVLPSSRSLNHQLAYIKNEFLGPLIEKRREMESSGDPNYEKPDDFLQWMMDLAKTEQESHPHNLAQRLLGITSMAVVHTSAMSLTHILYDLLVMPQWLQPLRDEIQEVNPDWHSTTQAHLIGLKGMDSFLKESQRFNPPGELSFHRVVKHDLTLSDGLFLPKGTHICMAAGPISRDADVMSDPDTFDAFRFVKENRPTSGFVSTGATNMHFGLGRYACPGRFFAAFVMKAILSRFLADYDFRFGPDQKDRPKNMMIGDKIVPNVSTPIFIRKRTTSKPL", "function": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems. The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (Probable). Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase penC then forms 3-geranylgeranylindole (3-GGI) (Probable). Epoxidation by the FAD-dependent monooxygenase penM leads to a epoxidized-GGI that is substrate of the terpene cyclase penB for cyclization to yield paspaline (Probable). Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase penP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase penQ. Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase PC-15 which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase penD (Probable). A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase PC-16 and the P.simplicissimum ptmI-ortholog not yet identified in P.crustosum, leads to the production of the prenylated form of penijanthine (Probable). The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase PC-22 (Probable). A series of oxidation steps involving 4 cytochrome P450 monooxygenases (PC-21, PC-05, PC-23, PC-20) and a FAD-dependent monooxygenase (PC-14) are required for the transformation of PC-M4 to penitrems A and E. Synthesis of these final products is proposed to proceed via penitrems D and C (PC-21, PC-05, PC-14) and penitrems B and F (PC-21, PC-05, PC-14, PC-23) (Probable).", "AFDB_id": "AF-A0A0E3D8K9-F1-model_v4" }, { "swissprot_id": "O75603", "sequence": "MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF", "function": "Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.", "AFDB_id": "AF-O75603-F1-model_v4" }, { "swissprot_id": "Q6FMB1", "sequence": "MFSLKLGKNKKKKKVPKGDSELFGSEASVDDKVSLTQYNYADEREKEKPKKRKIELATAESETIALKRAKNNIGDDSIVQELEALPEKVEDKEYEEMPVEEFGAAMLRGMGWTDENELEDSKSHSKKLPHEQIHPEGLGIGAKSQEMSNPVSVKDLVNDFMPVKKVPKQ", "function": "Involved in spliceosome maturation and the first step of pre-mRNA splicing.", "AFDB_id": "AF-Q6FMB1-F1-model_v4" }, { "swissprot_id": "Q9JI74", "sequence": "MSGSGRKDFDVKHILRLRWKLFSHPSPASSSPAGGSCLQQDSGGGSFEHWGPSQSRLLKNQEKGSVSAFWKKPSSSSSSSSSSSSSASSSPFNPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLEEEVVTGMDFSGPEDKGLALKELQAEPASSIQATGEGCGHRLTSTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMENYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP", "function": "May play a role in organizing the actin cytoskeleton of the brain cells.", "AFDB_id": "AF-Q9JI74-F1-model_v4" }, { "swissprot_id": "Q8PTT5", "sequence": "MLVTTSRKPSAKSRTLCKLLSRFTASRCISRGKMGMQELLDFTEGNTFIVVGEYHGNPGELSFHDNEGKLLFSIRFSDRYSEEIDSYWFPDVLPVLTGEGEIAEALESFFHFERVESDRVVQLPQNSLVMAIGDKEIDFMGSGKSLFKFNIKGFKKY", "function": "Probably involved in the biogenesis of the ribosome.", "AFDB_id": "AF-Q8PTT5-F1-model_v4" }, { "swissprot_id": "A8R3T0", "sequence": "MYKILIADDHPLFREAIHNVITDGFPGSEVMETADLDSALSLTGQHDDLDLILLDLNMPGMHGLGGLINLRNEAPTIPVVIVSAEQDKQVVLQAITYGAVGFITKSSPRSQMTDAIEQILNGNVYLPPDIIRTQKSTGRRNQSEHAGFAPELLQALTRKQLLVLERMTKGESNKQIAYNLDIAETTVKAHVSAILRKLNVHNRVQAILSAGDIDFTAYLRR", "function": "Positive activator for glycerol metabolism. Regulates the expression of qedA in a positive manner and governs the expression of ADH I and ADH IIB. General regulator of quinoprotein ethanol oxidation and affects expression of ADH IIG activity but is not the sole regulator.", "AFDB_id": "AF-A8R3T0-F1-model_v4" }, { "swissprot_id": "A0A2V5HP22", "sequence": "MASSRIVELATRISENTAIVDAYLRENQLPSPSFDEDGPVDFAIQGEEVKKAHEEAIALSWELHRLLLGPSHFLRPVPNGLSLQAISKHDIATKVPVHGKISYAALAQQCGLSEINTRRFVRYAIVHHRVFCEPQPGYVAHSAASRLLAEDPVMRDVLSHYLEECFPSFAMTLRAIDQFQDNGEPNQTGWNLYHETQDAPWDYYETHPAMARRFASTMAYETEREGRSSNVLVEGYAWTSLLAETTATTTSPLVVDVGGSRGKTALEIAHAHPELTLLVQDLPSMIEGARDQLPAIPARERVQFMAHDFFAPQLVPADAYILRHVFHNWSDRNAVRILRALVPSLQPGARLIVNDYIAPVPGVLSLAKEQRLREMDLIMLTLCNAYEREEQDWKRLFQEADPRFHVRTMSVPKGATEGILEVIWEG", "function": "O-methyltransferase; part of the gene cluster that mediates the biosynthesis of pyranoviolin A, a pyranonigrin analog with a C-3 methoxy group. Initially, the PKS portion of pyvA synthesizes C-10 carbon chain from 5 molecules of malonyl-CoA, which is then condensed with the thiolation (T) domain-bound glycine activated by the adenylation (A) domain. The subsequent chain release by Dieckmann condensation (DKC) could be catalyzed by the TE domain present at the C-terminus of pyvA and/or the alpha/beta hydrolase pyvD, installing the tetramic acid moiety (Probable). The FAD-dependent monooxygenase pyvC next epoxidizes one of the olefins of the polyketide part, and the epoxide ring-opening induces the dihydro-gamma-pyrone ring formation (Probable). The cytochrome P450 monooxygeanse pyvB would be responsible for the 2 consecutive reactions, in which the dihydro-gamma-pyrone is oxidized to gamma-pyrone and C-7 is hydroxylated to yield pyranonigrin F (Probable). Finally, the O-methyltransferase pyvH methylates the C-3 hydroxy group to complete the biosynthesis (Probable).", "AFDB_id": "AF-A0A2V5HP22-F1-model_v4" }, { "swissprot_id": "A5D369", "sequence": "MLQATGVILAGGRSRRMGQEKALLEVGREAMIRRVAGVLKEVFAEVIISGGVEENGLRLGLRVVPDLIAGGGPLSGIHAALCGAAFAKCLVVACDMPFICPELARYMMEQSEGYDVAVPRHGQHLQPLFAVYSKGCIRAIEESLRAHKCKVIDFYPLVRVNYVSEENLRALADIEVAFFNVNTPSDLVKARVMAENSRTGRVWLV", "function": "Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.", "AFDB_id": "AF-A5D369-F1-model_v4" }, { "swissprot_id": "P0CU85", "sequence": "MGLSEKVEFKTLDGLVLRGFLYSARAKGPAIVMTPGFNFPVSLLYHEVALGFQAAGITALVYDPRSVGRSDGLPRSDINPAKQSEDFSDAITFLKTKPVVDPKRIALWGYSLSAAAALMAAGLDPRVKLVVAVCPAPVPYNFEAPGKRRKYLDLAIRDRESQARGKEPFYVQYIGDSEETALFDYRKQRGMEELEYDEVVENLTKIAPGFRNEVTIQTLRRLGSWSFADVPQRVGPTPVLQVFAVHEELEHIRKTQEAIWAGLTGPKERHTEDRGHMDVLTPDGHRFAHLVKVQVDFVLKNFAQRMR", "function": "Thiohydrolase; part of the gene cluster that mediates the biosynthesis of phaeospelide A, a fungal polyene macrolide with a 34-membered macrolactone ring and an all-trans conjugated hexaene structure. The HR-PKS ApmlA uses acetyl-CoA and malonyl-CoA as its starter and extender units, respectively, and provides the large carbon framework in phaeospelide via 16 cycles of polyketide chain elongation, which is the largest number identified in fungal iterative PKSs thus far. During round 1, the KR domain reduces beta -ketone to an L-oriented hydroxy group, while during later rounds, it provides hydroxy groups in the D-configuration. The characteristic conjugated hexaene moiety is built during the later rounds (10-15), when the KR and DH domains are at work but ER is off. Phylogenetic analysis of the DH domain suggests that a polyene formation is programmed in the DH domain. Finally, the mature ACP-tethered carbon chain is transferred to the serine residue of the thiohydrolase apmlB, followed by intramolecular macrolactonization, generating phaeospelide A. When one elongation cycle during rounds 7-9 is skipped, phaeospelide B is biosynthesized instead.", "AFDB_id": "AF-P0CU85-F1-model_v4" }, { "swissprot_id": "Q9CJR6", "sequence": "MKQKIFQILTALCCIFYVMSAQAIDAKKLYGLQGPKLIYQAPVTKSHHYVVKGVSYRTQTSKEASGYARDGIASFYHKKFNGRKTASGQIYNENLYTAAHKTLPLNSYVLVTNLRNQRKVIVRINDRGPFVKGRIIDLSRAAAREIGLIGSGVGHVRVELIQLDRQGRISGAASATLAKLAKNQEAVNMLLQGEDTVELTQHTEEKTVKAATTKPEKYTTVYKIRILNLDSKKQAEKLISKLGREDIRADITVNQDKFDIYFGPFSDKSQVNDVKAQLRKLNYSKPLIVYTFDD", "function": "Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.", "AFDB_id": "AF-Q9CJR6-F1-model_v4" }, { "swissprot_id": "Q5TM52", "sequence": "MSWRDLPRLRLWLKTEAIPGEGRKAAKVNAGVGEKGIYTASSRGGPPSARSKAVAVVAQGAASRSRLSMDAPELGPGLVERLEQLATCPLCGGSFEDPVLLACEHSFCRACLARRWGTPPATDTEASPTACPCCGLPCPRRSLRSNVRLAVEVRISRELREKLAEPGARAGRRRGGRIPTMGCLDPPGEDMRKTWRRFEVPTPKSSKSEDDLPEDYPVVKNMLHRLTADLTLDPGTAHRRLLISADRRSVQLAPPGTPAPPDGPKRFDQLPAVLGAQGFGAGRHCWEVETADAASCRDSSGEDEDDEESHYAVGAAGESVQRKGCVRLCPAGAVWAVEGRGGRLWALTAPEPTLLGGAEPPPRRIRVDLDWERGRVAFYDGRSLDLLYAFQASVPLGERIFPLFCTCDPRAPLRIVPAES", "function": "May play a role in prolonged long term-potentiation (LTP) maintenance.", "AFDB_id": "AF-Q5TM52-F1-model_v4" }, { "swissprot_id": "Q9K498", "sequence": "MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR", "function": "Involved in the biosynthesis of the sesquiterpenoid antibiotic albaflavenone. Catalyzes the two-step allylic oxidation of epi-isozizaene to albaflavenone. First carries out a non-stereo-specific oxidation of epi-isozizaene to give a mixture of the albaflavenol epimers ((5R)-albaflavenol and (5S)-albaflavenol), each of which can serve as substrate for the second oxidation to yield albaflavenone. This is quite different from most other P450s which catalyze regio- and stereospecific oxidation. In addition, displays a farnesene synthase activity with farnesyl diphosphate (FPP) as substrate.", "AFDB_id": "AF-Q9K498-F1-model_v4" }, { "swissprot_id": "Q72B03", "sequence": "MTAQRRPTPHSSIWNSSMRKTLLRAACMAALTFMLSGCGIIDYFYLPPPEDTAQELYESGNDAMREKDYVAAAQAYTRLKDNYPFSPYTIEAELSLADAYFLDEEYPAAAEAYKEFETLHPRHQAIPYVLYQVGMARLKSFISVDRPVNNVQEAYQYFQRLRESYPGTEYAAKAEEHMKECRRLLAERELFIADVYWRTGKYGAAWQRYSFVRDNFKDVPHAVEYATEKANVAYLRHREAQSENIREAREGSWKQWFKWL", "function": "Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.", "AFDB_id": "AF-Q72B03-F1-model_v4" }, { "swissprot_id": "F8HZP7", "sequence": "MNEKNKNDESKHQEDKLQDQKMWNRINKFFSRSIGQSAKRAPKPKAISKSQSFRILNRFNAMERNSIHMIVILSIISLLLILLLSPLMRFQKVEITGNHDLTKAEVLAASGINKKIPAWQLLSEQHYFIQRAEKNSQIKKVKISYLNMQVAQIKIEENSKVGLVTKKDKNYYILADGKFIPAQSVGEKPQRLPNYEKFPNDKTIKRVAMQFNGISKALQNSVSEVIWSPDHEDDEKVILIMDDGNKVLIKASDIKNKLKYYPGMVAQIDKNGTFNFQVGTYFQQY", "function": "Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.", "AFDB_id": "AF-F8HZP7-F1-model_v4" }, { "swissprot_id": "Q27086", "sequence": "MLSRRTLDCCLVMLIVSTTFCQELHFYKEKADRSHENLKTAVNQFGIHLCRRLLNEGKNIIFSPFSLSTALSMAFVGARGNTAIEMRSGLGFREAGLAQEDVPDSFYQAFQLLKSDQSGDKFYVANTALVQNNYNILNSYKRILHRKFYSDIQPVDFVRNGLWVKEMVNKWVSNITHNKITSLIDKPLSPLTRLFLLNAVYFKGSWKTQFDRKRTTLSLFYNNNKVARRVEMMSLTNKFPYTYDSELKCQVLELPYDGDKTSMIFILPEWDVRLKHVENALSAQSVKQLINNLQDTEIVVTIPKFKLENSPQIKEYLQVMGMNEAFSFSADFSGMNGRRNLFVKDVLHKAMIDVNEEGSEAAAVSGVVVMLKSASHNLPTFVANHPFMFLIINKESGMILFLGSVREL", "function": "Serine protease inhibitor that inhibits proclotting enzyme and to a lesser extent clotting factor C and clotting factor G.", "AFDB_id": "AF-Q27086-F1-model_v4" }, { "swissprot_id": "Q10NX8", "sequence": "MAAATVGVLLRLLLLPVVVVVSLLVGASRAANVTYDHRAVVIDGVRRVLVSGSIHYPRSTPDMWPGLIQKSKDGGLDVIETYVFWDIHEAVRGQYDFEGRKDLVRFVKAVADAGLYVHLRIGPYVCAEWNYGGFPVWLHFVPGIKFRTDNEAFKAEMQRFTEKVVDTMKGAGLYASQGGPIILSQIENEYGNIDSAYGAAGKAYMRWAAGMAVSLDTGVPWVMCQQSDAPDPLINTCNGFYCDQFTPNSKSKPKMWTENWSGWFLSFGGAVPYRPAEDLAFAVARFYQRGGTFQNYYMYHGGTNFGRSTGGPFIATSYDYDAPIDEYGMVRQPKWGHLRDVHKAIKLCEPALIAAEPSYSSLGQNTEATVYQTADNSICAAFLANVDAQSDKTVKFNGNTYKLPAWSVSILPDCKNVVLNTAQINSQVTTSEMRSLGSSIQDTDDSLITPELATAGWSYAIEPVGITKENALTKPGLMEQINTTADASDFLWYSTSIVVKGDEPYLNGSQSNLLVNSLGHVLQIYINGKLAGSAKGSASSSLISLQTPVTLVPGKNKIDLLSTTVGLSNYGAFFDLVGAGVTGPVKLSGPNGALNLSSTDWTYQIGLRGEDLHLYNPSEASPEWVSDNAYPTNQPLIWYKTKFTAPAGDDPVAIDFTGMGKGEAWVNGQSIGRYWPTNLAPQSGCVNSCNYRGAYSSNKCLKKCGQPSQTLYHVPRSFLQPGSNDLVLFEQFGGDPSMISFTTRQTSSICAHVSEMHPAQIDSWISPQQTSQTQGPALRLECPREGQVISNIKFASFGTPSGTCGNYNHGECSSSQALAVVQEACVGMTNCSVPVSSNNFGDPCSGVTKSLVVEAACS", "function": "Releases galactose by hydrolysis of plant cell wall galactose-containing polysaccharides such as galacto-xyloglucan, pectic galactan and galactan (in vitro).", "AFDB_id": "AF-Q10NX8-F1-model_v4" }, { "swissprot_id": "Q59DY5", "sequence": "MMVKLLLLFLVCWSALPLESSPLGNRYNLEIGEKQYYISLAKTNWFEASNHCRQNGGFLLNLESREELELLSPHLHPAYSYWLSINDLGERGVYVSEATGLEAPFLNWSAGEPDNSSGYDRCVELWLSTTSFQMNDLPCYSSVAFICQLN", "function": "Galactose-specific lectin that displays calcium-dependent activity. Binds to the surface of hemocytes and enhances hemocyte encapsulation and melanization. This is likely by interacting with carbohydrates on the surface of the hemocytes. Also displays agglutination activity against the Gram-negative bacterium E.coli.", "AFDB_id": "AF-Q59DY5-F1-model_v4" }, { "swissprot_id": "Q84WK0", "sequence": "MEAMGEWSNNLGGMYTYATEEADFMNQLLASYDHPGTGSSSGAAASGDHQGLYWNLGSHHNHLSLVSEAGSFCFSQESSSYSAGNSGYYTVVPPTVEENQNETMDFGMEDVTINTNSYLVGEETSECDVEKYSSGKTLMPLETVVENHDDEESLLQSEISVTTTKSLTGSKKRSRATSTDKNKRARVNKRAQKNVEMSGDNNEGEEEEGETKLKKRKNGAMMSRQNSSTTFCTEEESNCADQDGGGEDSSSKEDDPSKALNLNGKTRASRGAATDPQSLYARKRRERINERLRILQNLVPNGTKVDISTMLEEAVHYVKFLQLQIKLLSSDDLWMYAPIAFNGMDIGLSSPR", "function": "Transcription factor involved in the regulation of root hair elongation. Does not seem to be a direct transcriptional target of RHD6 and RSL1. Involved in the regulation of root hair elongation in response to low phosphate.", "AFDB_id": "AF-Q84WK0-F1-model_v4" }, { "swissprot_id": "Q58151", "sequence": "MTHYCGINRMKEGTDFEKKHTPFIECKDRVKANDYFEVKISTGIPHPMEDNHFIHWIELYMGDLYLARVDFTQFMKPEVKLMVKAPSKEHEKFILRALMRCNLHGVWEYEKEILLE", "function": "Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.", "AFDB_id": "AF-Q58151-F1-model_v4" }, { "swissprot_id": "P02622", "sequence": "AFKGILSNADIKAAEAACFKEGSFDEDGFYAKVGLDAFSADELKKLFKIADEDKEGFIEEDELKLFLIAFAADLRALTDAETKAFLKAGDSDGDGKIGVDEFGALVDKWGAKG", "function": "In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.", "AFDB_id": "AF-P02622-F1-model_v4" }, { "swissprot_id": "Q751P4", "sequence": "MDEELQLKNWTELHNHIKSVLDRLDESRINESFQELLEVNVIRGRGILASEVVREERVVRQGAVLGALVELFEDYIPELGIMVSREALLLFLKSFRGGRTKYCYGLLALLCQLCNSDVMHEIGLLQLADLLLEVPRDRAVGMLCFMLGQAGAHLMNVCRTAHDQLLARLTDMLHDGKLSPTSSNRIQELLRLRRSNYKGQATKFSLPDHGVCTHRVTLELDIPARLEPDSSLGKFYVDNQFFDTEERFAALRRQALERFLGQQQQQAEPVKDMTNAEEVQYKKQIYLILKGSLTGDEAAHKLLKLRPDASQKATIVEIVVKACAQEQTYTKFYGILAERLCGSHRNWPTSFTNLFRDLYGTLHEFEPNQLRNMGKFWGHMLAADHIGLNLFECVHLSEHRTTPSSRVFLKFIFQELVADLGIAEVRKRLEDENAQPLVQGLFPKEGNADTVFAINYFTAIGLGVLTESMRTSLPTQAKSDSGNMSPNGQTLSYPSSRVPRRTRSRSPPRTRVRGDSPQRARVEQRYSRYDPGPAHRDRRRSRLSVTPPPRRNIH", "function": "May be involved in pre-mRNA splicing.", "AFDB_id": "AF-Q751P4-F1-model_v4" }, { "swissprot_id": "B2VAA3", "sequence": "MARLVFRKNGKVIENPEEIKSFLSQYGVVYDVWGVDRLPEDVRKNYDIDEENSKAIIQAYEKELKELKEKMGYITEDIVVLSEKTPNLDGLMAKFKREHHHIDDEVRFVVDGSGIFPVKIEDDIVDIHVEAGELIVVPAGARHWFELDENRKIKCIRVFKTPAGWEAIYNENETATMRD", "function": "Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.", "AFDB_id": "AF-B2VAA3-F1-model_v4" }, { "swissprot_id": "Q13887", "sequence": "MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQAQPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPPAPTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRHQN", "function": "Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.", "AFDB_id": "AF-Q13887-F1-model_v4" }, { "swissprot_id": "O14229", "sequence": "MNSLKISDNEYALIEHPGFANNKDAFFQTLGGVQSIQKACQTSFQNPKQALLELNLRPKDKYHHPVQARVQSRNDLLVTIKKMDNSVQNVSRIRQVFLFRDMADFQYSTQNSPFVQKLDSTLRVLDYNAINKFSIDLTPVQRKHVDMPPPPVFSQTSLPMSYNFLQNPLVGRVRLPNGKTTIVNLKGQCRVWIITTNMGVESVPTCRHSKLGEPSKTIQEVIEALKPLFEKRPVWTRRALLNHLDPSYTHYLKFALPYLSYLWTSGPFRDTYTRFGYDPRKDSNAAAYQALFFKLKLNGKHKGTKTHVFDGKTLFPTNRVYQVCDIVDPTIAPLLKDTQLRSECHRDTGWYRSGRYYKVRDLMREKLFALIEGEMPSEVAVNMILNAEEVEESDRYSNFDEQDNTDLNDTVRGLNTSATDDRINDLMRNLMKRSQEHEGFEDLEEIDDDYDDIFGD", "function": "TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.", "AFDB_id": "AF-O14229-F1-model_v4" }, { "swissprot_id": "B3FWR8", "sequence": "MVIKLYGSAMSTARVLVTLLEKELPYEHILVDISKGDQNKEEYLKLQPFGKVPVLDDNGFIMYESRAICRYLARKYDSGTKLIPDVDDHEAYGRFEQGCSIEYSYFAAAAETLGTELVIKKYKGLGEPDMTRVAQAEADFDKVFFEYDKILAKQKYLTGDEISLVDLFHLPNASALKAFGYQGTFEKYPNVNRWFSGLQARETWIKATAEAR", "function": "Glutathione S-transferase; part of the gene cluster that mediates the biosynthesis of hypothemycin, a resorcylic acid lactone (RAL) that irreversibly inhibits a subset of protein kinases with a conserved cysteine in the ATP binding site such as human ERK2. The first step is performed by both PKSs hmp3 and hmp8 and leads to the production of 7',8'-dehydrozearalenol (DHZ). The highly reducing PKS hpm8 synthesizes the reduced hexaketide (7S,11S,2E,8E)-7,11-dihydroxy-dodeca-2,8-dienoate, which is transferred downstream to the non-reducing PKS hpm3. Hpm3 then extends the reduced hexaketide to a nonaketide, after which regioselective cyclization and macrolactonization affords DHZ. The next step is the conversion of DHZ into aigialomycin C and is performed by the O-methyltransferase hmp5, the FAD-binding monooxygenase hmp7, and the cytochrome P450 monooxygenase hmp1. The wide substrate tolerance of the hmp5 and hmp7 implies that the reactions from DHZ to aigialomycin C can occur in any order. The steps from aigialomycin C to hypothemycin are less well established. The FAD-linked oxidoreductase hmp9 presumably catalyzes oxidation of the C-6' hydroxyl to a ketone. The timing of this oxidation is important, since the resulting enone functional group is a Michael acceptor that can react spontaneously with glutathione, an abundant metabolite in fungal cells. The glutathione S-transferase hmp2 catalyzes cis-trans isomerization of the 7',8' double bond with equilibrium favoring the trans isomer. The hpm6-encoded transporter might preferentially pump hypothemycin out of the cell relative to the trans isomer aigialomycin A. The cis-to-trans isomerization may be coupled with C-4' hydroxylation, since all known hypothemycin analogs containing the enone functional group also have hydroxyl groups at both C-4' and C-5'.", "AFDB_id": "AF-B3FWR8-F1-model_v4" }, { "swissprot_id": "Q9FYE5", "sequence": "MSSSAKKQTLFISTLIISWYSSNIGVLLLNKFLLSNYGFKFPIFLTMCHMSACAILSYISIVFLKLVPLQHLKSRSQFLKVATLSIVFCASVVGGNISLRYLPVSFNQAVGATTPFFTALFAYLMTFKREAWVTYGALVPVVAGVVIASGGEPGFHWFGFIMCISATAARAFKSVLQGILLSSEGEKLNSMNLMLYMSPIAVIALLPVTLFMEPDVISVTLTLAKQHQYMWILLLVNSVMAYSANLLNFLVTKHTSALTLQVLGNAKGAVAVVISILIFQNPVTVMGIGGYSITVLGVVAYGETKRRFR", "function": "UDP-glucuronic acid transporter that modulates the polysaccharide composition of seed mucilage. Transports UDP-glucuronic acid (UDP-GlcA) and UDP-galacturonic acid (UDP-GalA) in vitro.", "AFDB_id": "AF-Q9FYE5-F1-model_v4" }, { "swissprot_id": "A0PA72", "sequence": "MNDAKKYIVSVLILLVAGMFGGCIKEDYSDCPRPFRLTVRAWDADMQDITETGAVQRVVIFVFDETGRRIDRLMMDAAQVAARKPIPLEYDGPTTVSFVAWANPDDHMLEETANVQNVKDLFFRLSSTDGIAQSPGDLFSGVLTCPIEYGSIEQGTDQTVDIYRRTAQVHIIIRGYQEWLDANGPRQLPDYADILLGETPDTYTGLAELIGNAVQYRPDGQIQNGDFISPIFRVYPTLDTTPLHLKLYAYGQELLNISTGSDGVPFIPVIGKMLNIYIDLRGANLNVLVSVTPWDVVQQQQYAEY", "function": "Anchoring subunit of the major fimbriae. Regulates fimbrial length. These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. Fimbriae of P.gingivalis are major virulence factors.", "AFDB_id": "AF-A0PA72-F1-model_v4" }, { "swissprot_id": "P15268", "sequence": "MFRMDSSGRRSRSRRSRGSSGAPNMFEGTTTSRSRQEQLLASLEQMRGSSGPSNTEGTTSRAADLVAPTMAPTAEAAVDAEAAVDAEAEEAAAELDDGEETSGADASTEEAATQAPPRRAIRYRRSLTLKPSKPFDQRRVIEPKGTRAWKEVSWDGTGHRTPILTELGICLRFAYPAMVTEGGQEIAAHYWAHWDLKPYGNDGTHTSKVWDLFWGQFRVCDPYTLDDSYVREVFNGSADRAVKGMMYKARLRAVTVYQKRQGNYCDANMAKEIHLTAQQYKESEVDWLSHHSDAWAWMCEYWASEEFLAISNRNRMNRLSKPGVHFFGADGHVGKAARMAARNGVEPTLLQVFVEGHKGPDPNHPEILNDSNATEKLARYIDNVREKNGPDTDWLTGEFDTEAAYKAGGGVPHGRLAIGDGVVPRRSYTRRSNFSAGSNRPRRPSAREGELLEKMTQMEESMAQYKQQVQQQMQQMQNWMLHQMYGGAGTQFGMPPFQQPPIITHPVSGQSSDRSTAAADGSQGSATSVQDQLMPLGVIGGQMMPWAPRQPGIWPPMQTQMPPPMPWGFPPRGQSQSPGLPSHSPGSGSGSHHASPPPDQSTFMDLLMNTSGGGSNDPPTE", "function": "This protein has most probably three functions; the mutator (M) function, for excision and transposition; the suppressor (S) function, which inhibits residual gene activity of certain alleles in which inhibitor elements are integrated; an activator (A) function is proposed, because inactive SPM can be activated by a second SPM.", "AFDB_id": "AF-P15268-F1-model_v4" }, { "swissprot_id": "Q86L04", "sequence": "MQRTLSKVILNSGKNNLLKSSNLLNSNLLKATTTNIIGIKTINNNNNVNSIIGFKSLNKRYFTSNTPKVEEEDDEIAPDEAIKAEEKIKETERVIGLSEKLSFQTETQKILHIVAESLYTEKEVFIRELISNASDAIEKVRHTQLTNASMIEDASIPFEIKISTDEDNKTLIIQDSGIGMTKDEMIKNLGKIGYSGSSDFIKKLGENPDKASIIGQFGVGFYSCFMVGHTIKIYTKSATPGSKGYLWESDGTGSYSITEAEGVSRGTKIIIHLKPSSYEYSKKSIVENIIKKYSNFVGFPIALNGTTVNTIKPLWTLNKNAISEEEHKEFYQFLSKSYDTPSYRVHFSTDTPLSIRSIFYIPSQHMEKYGMGKMEPGVSLFSRKVLIQQKANGILPEWMRFVRGVVDSEDIPLNVSREHLQDNGLIQRISSVLVKRILKHLNDEAKSDPEKFNVFMTEFGGFFKEGIITDFKWKDEISKLLRFESSNGSTASKTDAVSLEQYVSRMKPEQKNIYFLSVPNRAVGLSSPYYEPFQLKDIEVIFLYNAVDEFVLTNVGHFGDKKIVSVESKEAEEFLATNQDKKTETLSQDEIDKFLSWVSTVASDKVTQAKSTTRSISSPAIIIDHESANFRRMLKMVEPGKQHETPKQVVEFNMNHPIILKLVQQTESNPTIAKLVIDQVVDNAFVSAGLIEDNREMIPRINQLLDSLLTK", "function": "Chaperone that expresses an ATPase activity.", "AFDB_id": "AF-Q86L04-F1-model_v4" }, { "swissprot_id": "L7N680", "sequence": "MSFVVTVPEAVAAAAGDLAAIGSTLREATAAAAGPTTGLAAAAADDVSIAVSQLFGRYGQEFQTVSNQLAAFHTEFVRTLNRGAAAYLNTESANGGQLFGQIEAGQRAVSAAAAAAPGGAYGQLVANTATNLESLYGAWSANPFPFLRQIIANQQVYWQQIAAALANAVQNFPALVANLPAAIDAAVQQFLAFNAAYYIQQIISSQIGFAQLFATTVGQGVTSVIAGWPNLAAELQLAFQQLLVGDYNAAVANLGKAMTNLLVTGFDTSDVTIGTMGTTISVTAKPKLLGPLGDLFTIMTIPAQEAQYFTNLMPPSILRDMSQNFTNVLTTLSNPNIQAVASFDIATTAGTLSTFFGVPLVLTYATLGAPFASLNAIATSAETIEQALLAGNYLGAVGALIDAPAHALDGFLNSATVLDTPILVPTGLPSPLPPTVGITLHLPFDGILVPPHPVTATISFPGAPVPIPGFPTTVTVFGTPFMGMAPLLINYIPQQLALAIKPAA", "function": "Expression in Mycobacterium smegmatis, a nonpathogenic species naturally deficient in PE_PGRS genes, results in enhanced resistance to various in vitro stresses. It also leads to phagosome maturation arrest and increased survival in macrophages.", "AFDB_id": "AF-L7N680-F1-model_v4" }, { "swissprot_id": "Q05019", "sequence": "MRIKFLVVLAVICLLAHYASASGMGGDKKPKDAPKPKDAPKPKEVKPVKADSSEYEIEVIKHQKEKTEKKEKEKKAHVEIKKKIKNKEKKFVPCSEILKDEKLECEKNATPGYKALFEFKESESFCEWECDYEAIPGAKKDEKKEKKVVKVIKPPKEKPPKKPRKECSGEKVIKFQNCLVKIRGLIAFGDKTKNFDKKFAKLVQGKQKKGAKKAKGGKKAEPKPGPKPAPKPGPKPAPKPVPKPADKPKDAKK", "function": "Used by the larvae to construct a supramolecular structure, the larval tube.", "AFDB_id": "AF-Q05019-F1-model_v4" }, { "swissprot_id": "O31216", "sequence": "MRKLILATFLLLAPTALLASGGGEHLESANIDLRDQASLQRGAKYFMNYCTGCHSLQYMRYNRLAKDLGIDEIALRQNLLFGDAKPGDLITKAMTDDDALKWFGVVPPDLTLVTRWRSPDWVYTYLKSFYLDDTRPYGVNNVLFPLVGMPHVLGDLQGRQEAVMEPSHEPGGEPTIKGVKLVEEGGLSPQEYDTMVRDITNFLTYAGEPFQLERERIGRYVLLFLGFLFILAYLLKKEYWKDVH", "function": "Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c.", "AFDB_id": "AF-O31216-F1-model_v4" }, { "swissprot_id": "P40363", "sequence": "MKVVKEFSVCGGRLIKLSHNSNSTKTSMNVNIYLPKHYYAQDFPRNKRIPTVFYLSGLTCTPDNASEKAFWQFQADKYGFAIVFPDTSPRGDEVANDPEGSWDFGQGAGFYLNATQEPYAQHYQMYDYIHKELPQTLDSHFNKNGDVKLDFLDNVAITGHSMGGYGAICGYLKGYSGKRYKSCSAFAPIVNPSNVPWGQKAFKGYLGEEKAQWEAYDPCLLIKNIRHVGDDRILIHVGDSDPFLEEHLKPELLLEAVKATSWQDYVEIKKVHGFDHSYYFVSTFVPEHAEFHARNLGLI", "function": "Serine hydrolase involved in the detoxification of formaldehyde.", "AFDB_id": "AF-P40363-F1-model_v4" }, { "swissprot_id": "Q9P2Y5", "sequence": "MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQQIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETERKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQAEEIIGLEATGFASGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK", "function": "Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation.", "AFDB_id": "AF-Q9P2Y5-F1-model_v4" }, { "swissprot_id": "P39140", "sequence": "MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYAKEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYMHETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLFAEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALLFRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSILVAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL", "function": "Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome.", "AFDB_id": "AF-P39140-F1-model_v4" }, { "swissprot_id": "A0QRY0", "sequence": "MTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAWTFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAAQTG", "function": "Toxic component of a type II toxin-antitoxin (TA) system. Upon overexpression causes bacteriostasis. Its effect is neutralized by coexpression with cognate antitoxin PhD. May bind the 30S ribosomal subunit. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.", "AFDB_id": "AF-A0QRY0-F1-model_v4" }, { "swissprot_id": "W3X7S0", "sequence": "MSPPHSEHSNVPSDVAAGGGPKKSPPAGTQKLRAPRMRASCDGCFLAKVKCSKGKPMCQRCMTTGLACKYSPSSRSGKPKASDNGNILNGAPRHAKREGLQFSSPVFEGSQDLMAGPAQFMQNNWGSNQQAMWDLPTHQDPGTNFGSGPLNESLGQDIGIMDGISHDGGVMPFSENLADTNPWQSQNPSSSFSQMLPGSSGSMIHGRSQSTDMMISLVAANFQDTNAQAGPSHGPPLGQMAGPSHGPLGQMAVPLHGPPLGQMAGLSHGPLGQMTSPPNPAHARHHSDPAIGTGHVLSCNFDCTHQSLQRLNFMLATSSWPSDMLMTANENLCDAWRVIMRCPNCMGSGARRYMALAFLATSMQIQSRRLQAFLDTVKPNHDGVFPTVSNPAEKLNRLGTAITQIDQAYALLLRSFNNEMIEHPGVAQALANGVHKSLDAAVSLLLRKRTELAGTN", "function": "Transcription factor that positively regulates the expression of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment forming a dark layer in the conidial wall that protects the conidia from UV radiations. PfmaF assists PfmaH in promoting melanin synthesis. PfmaF may function as a broad regulator promoting also other secondary metabolism as well as fungal development.", "AFDB_id": "AF-W3X7S0-F1-model_v4" }, { "swissprot_id": "A7X4K1", "sequence": "MTLRRGSCPLLLFSLVGLLTTCAQEPDAAGQNTTAVAEKAGTCPQAELEMPDRNCTEACQSDAGCEENKKCCRTGCGTSCQIPDEKPGSCPNVDTPIPPLGLCKTTCSKDSDCSETKKCCKNGCGFMTCTTARP", "function": "Damages membranes of susceptible bacteria. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.", "AFDB_id": "AF-A7X4K1-F1-model_v4" }, { "swissprot_id": "O43541", "sequence": "MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR", "function": "Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.", "AFDB_id": "AF-O43541-F1-model_v4" }, { "swissprot_id": "P37386", "sequence": "MDSSTKTLTEDKQVYRVEGFSCANCAGKFEKNVKELSGVHDAKVNFGASKIDVFGSATVEDLEKAGAFENLKVAPEKARRRVEPVVTEDKNVYRVEGFSCANCAGKFEKNVKQLAGVQDAKVNFGASKIDVYGNASVEELEKAGAFENLKVIPEKLANPSIQAVKEDTKAPKEEKIPFYKKHSTLLFATLLIAFGYLSHFVNGEDNLVTSMLFVSSIVIGGYSLFKVGFQNLIRFDFDMKTLMTVAVIGAAIIGEWAEASIVVILFAISEALERFSMDRARQSIRSLMDIAPKEALVRRNGQEIMIHVDDIAVGDIMIVKPGEKIAMDGIIINGVSAVNQAAITGESVPVAKTVDDEVFAGTLNEEGLLEVKITKYVEDTTISKIIHLVEEAQGERAPAQAFVDKFAKYYTPIIMVIAALVAVVPPLFFGGSWDTWVYQGLAVLVVGCPCALVITTPISIVSAIGNAAKKGVLIKGGVYLEELGAIKAIAFDKTGTLTKGVPVVTDFKVLNDQVEEKELFSIITALEYRSQHPLASAIMKKAEQDNITYSDVRVKDFTSITGRGIQGNIDGTTYYIGSPRLFKELNVSDFSLEFENKVKVLQNQGKTAMIIGTDQTILGVIAVADEVRETSKNVILKLHQLGIKQTIMLTGDNQGTAEAIGAHVGVSDIQSELLPQDKLDYIKKMKAEHGNVAMIGDGVNDAPALAASTVGIAMGGAGTDTAIETADIALMGDDLSKLPFAVRLSRKTLNIIKANITFAIGIKIIALLLVIPGWLTLWIAILSDMGATILVALNSLRLMRVKDK", "function": "Couples the hydrolysis of ATP with the export of cadmium. Involved in cadmium resistance.", "AFDB_id": "AF-P37386-F1-model_v4" }, { "swissprot_id": "Q9LXX5", "sequence": "MATASLVPTSKIFSVSPKSSASIKARSRVVVASSQQQQQPRRRELLLKSAVAIPAILQLKEAPISAAREVEVGSYLPLSPSDPSFVLFKAKPSDTPALRAGNVQPYQFVLPPNWKQLRIANILSGNYCQPKCAEPWIEVKFENEKQGKVQVVASPLIRLTNKPNATIEDLGEPEKVIASLGPFVTGNSYDSDELLKTSIEKIGDQTYYKYVLETPFALTGSHNLAKATAKGSTVVLFVVSATEKQWQSSQKTLEAILDSFQL", "function": "May be involved in the redox regulation of photosystem II.", "AFDB_id": "AF-Q9LXX5-F1-model_v4" }, { "swissprot_id": "P29485", "sequence": "MGYVRVIYQFPDNLWWNECTNQVYYAQDPMKPERLIGTPSIIQTKLLKILCEYHPAPCPNDQIIKALWPHGFISSESLTQAIKRTRDFLNDEHKTLIENVKLQGYRINIIQVIVSENVVDEADCSQKKSVKERIKIEWGKINVVPYLVFSALYVALLPVIWWSYGQWYQHELAGITHDLRDLARLPGITIQKLSEQKLTFAIDQHQCSVNYEQKTLECTKN", "function": "Involved in TCP pilus biogenesis.", "AFDB_id": "AF-P29485-F1-model_v4" }, { "swissprot_id": "Q54BL2", "sequence": "MAQKRKNDKIETSKKEEIDPRFVNKFEDLEENDFKDDDEDDFINDVNEGEEEEEEEDNEDNIEFNQEEDDEDEDDEENKDNKNKIKKVIKIKPMDIEKMKKLKEQNENKGIIYLSTIPSRMKPAKLKQLLAKYGKVTRMHLVRANVERKNHRNDMFKEGWIEFEDKALARKIATILNNIPMGGKARDIHKDCLWNLRYLPKFKWHHLQDKLVSQRMERDKKLRLEINQVRKQNLILLEQVELSKHVNQKHESKGKPIKEKVVRTFKQRSSHEDSLNSNISSKVLEKVVSNKKQKIN", "function": "May be involved in the small subunit (SSU) processome assembly and function, and in the 17S rRNA synthesis.", "AFDB_id": "AF-Q54BL2-F1-model_v4" }, { "swissprot_id": "Q46EH4", "sequence": "MLDFTEASLKKVLTRYNVALEKALTPEEAAEELYPKDELIYPIAKAIFEGEEDDVVEGLQAAIEAGKDPIDLIDDALMVGMGVVIRLYDEGVIFLPNVMMSADAMLEGIEYCKENSGATPKTKGTVVCHVAEGDVHDIGKNIVTALLRANGYNVVDLGRDVPAEEVLAAVQKEKPIMLTGTALMTTTMYAFKEVNDMLLENGIKIPFACGGGAVNQDFVSQFALGVYGEEAADAPKIADAIIAGTTDVTELREKFHKH", "function": "Harbors a corrinoid prosthetic group and acts as a methyl group carrier in methanogenesis in the methanol pathway. The methyl group of methanol is first transferred to the corrinoid prosthetic group of MtaC in the cob(I)amide oxidation state. This reaction is mediated by MtaB. The methyl group from MtaC is then transferred to coenzyme M by MtaA.", "AFDB_id": "AF-Q46EH4-F1-model_v4" }, { "swissprot_id": "O06581", "sequence": "MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQLENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHAVSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAETELPPARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDIQLAELMRDRFGISVVIDDNLPDTAKRRYHPDTKVLRVAHWLMPGQRAFQIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYFAGAFLLPYREFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTDKAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRSYFWVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPSTEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV", "function": "Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate. PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor. During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA, which encodes the DnaA initiator protein responsible for initiating chromosomal replication. It is possibly involved in the regulation of genes responsible for controlling cholesterol utilization.", "AFDB_id": "AF-O06581-F1-model_v4" }, { "swissprot_id": "P16933", "sequence": "MFARLPVVFLYAFVAFGALVAALPGGHPGTTTPPVTTTVTVTTPPSTTTIAAGGTCTTGSLSCCNQVQSASSSPVTALLGLLGIVLSDLNVLVGISCSPLTVIGVGGSGCSAQTVCCENTQFNGLINIGCTPINIL", "function": "Contributes to surface hydrophobicity, which is important for processes such as association of hyphae in reproductive structures, dispersal of aerial spores and adhesion of pathogens to host structures.", "AFDB_id": "AF-P16933-F1-model_v4" }, { "swissprot_id": "A9VDW7", "sequence": "MACSCLLMASMQTLPGPGAFRTENGTLYLAFQEYYEAPQDPHNMADALSQTLSNSSLSQTLLSQTLISHTFLSQTLLSNSSLSHSLTLSQNSQTLLSQTLLSQTLLSLLSLTLSHSLKTLSNSFFSLKLFSLKLLDVFSLSHTRTSTREDGGDGQDGHEDRVWDVKWSPTGAVLASSSGDQTVRLWTREARDWVCLSTLEGPQKGTIRSLSWGREGNYLAAASFDSTTCVWEKGPSGFECFATLEGHENEVKGVAFSASGDYIATWFADEEEFDCAAILAEHSQDVKAVAWHPTRDLLASCSYDNTIRFYRADPDNADWICCDTLSDNQSTVWKICFNADGSRLAAVGDDRTLRVYQAFPPGNPQGAALPAHSSIYAPCLRNTLHSAINRLVCSDFAGIVTPSASDDKWKCIATITGQHTRPIYSVDWDPETNILATAGGDNIVRLFRETAVQPDTNTPSYELIGQFQAHDQDLNGLAWAPNQPDLQHRLLATCADDGLHVGNHKS", "function": "Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.", "AFDB_id": "AF-A9VDW7-F1-model_v4" }, { "swissprot_id": "Q59VP0", "sequence": "MLSKRLFPYSNLFPRSRKYKFIVYFIICLTIIISALGVYLYSIPIVSPNQPQCDMVWMSPSYARIRAFDETHTKYASKYNLYLYREQDVDKMPNENENEDGNEGFTSLDGIPALFIHGNAGSFEQVRSIAARCSEMYYNDGRFKEKYPHARNIDFFTADFNEELSAFKGLRDQVEYVTQAISFIVDLYPQNPNRNIILIGHSMGGLVARIAASRQQHESNVDIILTLATPHSDPFPWLPKTSDFPDEVGLISIYSSVDLMVPPSVVTPKSKSDHFFSVDAAKLLGVPIDHQGIVWCGQLREKLSEALIGISGLNTLQDRMKVFKKIFSGDRKELGPTPIFGLAKLKLKLLQSWVHLLSLTIFALKWTIIVLAIIQLRKVYTKFNNPPPTH", "function": "Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.", "AFDB_id": "AF-Q59VP0-F1-model_v4" }, { "swissprot_id": "P56621", "sequence": "MADVEEWLTHARKVTQEASIGVDVTSIQECISAEPAQRVLVARRDAWRAICCAAFAALVAFAAINRVATIMLEKPAPTWVATPSAASPFGLLIGK", "function": "CnrH alone is able to activate cnr expression, and both CnrY and CrnX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift, PubMed:10671463 or absence of the transcript, PubMed:10671464), nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.", "AFDB_id": "AF-P56621-F1-model_v4" }, { "swissprot_id": "P13606", "sequence": "MRLFGYARVSTSQQSLDIQIKGLKEAGVKASRIFTDKASGSSTDRKGLDLLRMKVEEGDVTLVKKLDRLGRDTADMIQLTKEFDAQGVAVRFIDDGISTDGEMGKMVVTILSAVAQAERRRILERTNEGRQEAKLKGIRFGRKRIIDRNSVLALHQQGTGATDIARRLSIARSTVYKILEDESRVNLSKI", "function": "Site-specific recombination protein.", "AFDB_id": "AF-P13606-F1-model_v4" }, { "swissprot_id": "Q9SIP1", "sequence": "MICARIRPLISSPLAFTISTTKHSRINLRLLPRRSFSVMSSSTPQSQIIEHIVLFKTKDDADSTKITSMINNLNALAYLDQVLHISTSPLHRISSATAFTHVLHSRYESKEDLASYAAHPDHVRVVKESVLPICDDIMAVDWIADRIPGTVAPLPGSVAKLTLLKLKEDVADEAKSEITGVIKGLSEKFPGIDQITVGENFSPARAKGFSIASIAYFKDLSEMEAVDAQKELVNSQKDKVRDYVDSTIVVEFVVPSSSQSSSL", "function": "Involved in stress response.", "AFDB_id": "AF-Q9SIP1-F1-model_v4" }, { "swissprot_id": "Q61292", "sequence": "MEWASGEPGRGRQGQPLPWELRLGLLLSVLAATLAQAPSLDVPGCSRGSCYPATGDLLVGRADRLTASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPNSHRIQNVVTSFAPQRRTAWWQSENGVPMVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGIPLAPPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYELVIRGNCFCYGHASQCAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCEFCRPFFYRDPTKDMRDPAVCRPCDCDPMGSQDGGRCDSHDDPVLGLVSGQCRCKEHVVGTRCQQCRDGFFGLSASDPRGCQRCQCNSRGTVPGSSPCDSSSGTCFCKRLVTGHGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEATGQCRCRQHMIGRRCEQVQPGYFRPFLDHLTWEAEAAQGQGLEVVERLVTNRETPSWTGPGFVRLREGQEVEFLVTSLPRAMDYDLLLRWEPQVPEQWAELELMVQRPGPVSAHSPCGHVLPKDDRIQGMLHPNTRFLVFPRPVCLEPGISYKLKLKLIGTGGRAQPETSYSGLLIDSLVLQPHVLVLEMFSGGDAAALERRTTFERYRCHEEGLMPSKAPLSETCAPLLISVSALIYNGALPCQCDPQGSLSSECSPHGGQCRCKPGVVGRRCDVCATGYYGFGPAGCQACQCSPDGALSALCEGTSGQCPCRPGAFGLRCDHCQRGQWGFPNCRPCVCNGRADECDTHTGACLGCRDYTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHRDGYSQQIVCQCREGYTGLRCEACAPGHFGDPSKPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHNTEGPHCGYCKPGFHGQAARQSCHRCTCNLLGTDPRRCPSTDLCHCDPSTGQCPCLPHVQGLNCDHCAPNFWNFTSGRGCQPCACHPSRARGPTCNEFTGQCHCHAGFGGRTCSECQELYWGDPGLQCRACDCDPRGIDKPQCHRSTGHCSCRPGVSGVRCDQCARGFSGVFPACHPCHACFGDWDRVVQDLAARTRRLEQWAQELQQTGVLGAFESSFLNMQGKLGMVQAIMSARNASAASTAKLVEATEGLRHEIGKTTERLTQLEAELTAVQDENFNANHALSGLERDGLALNLTLRQLDQHLEILKHSNFLGAYDSIRHAHSQSTEAERRANASTFAVPSPVSNSADTRRRTEVLMGAQKENFNRQHLANQQALGRLSAHAHTLSLTGINELVCGAPGDAPCATSPCGGAGCRDEDGQPRCGGLGCSGAAATADLALGRARHTQAELQRALVEGGGILSRVSETRRQAEEAQQRAQAALDKANASRGQVEQANQELRELIQNVKDFLSQEGADPDSIEMVATRVLDISIPASPEQIQRLASEIAERVRSLADVDTILAHTMGDVRRAEQLLQDAHRARSRAEGERQKAETVQAALEEAQRAQGAAQGAIWGAVVDTQNTEQTLQRVQERMAGAEKSLNSAGERARQLDALLEALKLKRAGNSLAASTAEETAGSAQSRAREAEKQLREQVGDQYQTVRALAERKAEGVLAAQARAEQLRDEARDLLQAAQDKLQRLQELEGTYEENERALEGKAAQLDGLEARMRSVLQAINLQVQIYNTCQ", "function": "Laminin-3 (S-laminin) regulates the formation of motor nerve terminals.", "AFDB_id": "AF-Q61292-F1-model_v4" }, { "swissprot_id": "P41796", "sequence": "MGINEIIMYIMMFFMLIAAVDRILSQFGGSARFLGKFGKSIEGSGGQFEEGFMAMGALGLAMVGMTALAPVLAHVLGPVIIPVYEMLGANPSMFAGTLLACDMGGFFLAKELAGGDVAAWLYSGLILGSMMGPTIVFSIPVALGIIEPSDRRYLALGVLAGIVTIPIGCIAGGLIAMYSGVQINGQPVEFTFALILMNMIPVLIVAVLVALGLKFIPEKMINGFQIFAKFLVALITIGLAAAVVKFLLGWELIPGLDPIFMAPGDKPGEVMRAIEVIGSISCVLLGAYPMVLLLTRWFEKPLMNVGKLLNVNNIAAAGMVATLANNIPMFGMMKQMDTRGKVINCAFAVSAAFALGDHLGFAAANMNAMIFPMIVGKLIGGVTAIGVAMMLVPKDDAAQVKTEAEAQS", "function": "Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon. EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection.", "AFDB_id": "AF-P41796-F1-model_v4" }, { "swissprot_id": "Q94EH8", "sequence": "MSDALNMTLDEIVKKSKSERSAAARSGGKGVSRKSGRGRGGPNGVVGGGRGGGPVRRGPLAVNTRPSSSFSINKLARRKRSLPWQNQNDLYEETLRAVGVSGVEVGTTVYITNLDQGVTNEDIRELYAEIGELKRYAIHYDKNGRPSGSAEVVYMRRSDAIQAMRKYNNVLLDGRPMKLEILGGNTESAPVAARVNVTGLNGRMKRSVFIGQGVRGGRVGRGRGSGPSGRRLPLQQNQQGGVTAGRGGFRGRGRGNGGGRGNKSGGRGGKKPVEKSAADLDKDLESYHAEAMNIS", "function": "Export adapter involved in nuclear export of spliced and unspliced mRNA.", "AFDB_id": "AF-Q94EH8-F1-model_v4" }, { "swissprot_id": "D2NT85", "sequence": "MARPPVVGVFTERKPMRAWDAPASVTLPGQAALPRIFDTAAGEIVQVQEDKAASLYVCGITPYDATHMGHASTYVAFDLLHRAWLDAGVPVTYVQNVTDVDDPLLERATATNVDWRELAEDQTELFRTDMKALNVIPPAHYVGVVESIEWLFPLIEDLFRRGLAYRVPGFTDEQGVVHPDGDVYLDLKAVRELPANAEGYSWAPGEVCHLTRDEMLEIFAERGGDPNRAGKRDALDPLLWRVEREGEPSWDAGELGAGRPGWHIECTMIARRFVDGSLTVQAGGNDLTFPHHDLGAGHSWAVSARPHAKHYAHTGMVGLDGHKMSKSRGNLVLVSRLRAAGEDANAVRLAIMGQHYRSDWFWTDELLEHAKARLDTYRHAVSVAEGREGSEGVTDEAAVELLTTVREALGEDLNAPAALAAVDAWAVKALADTTVGGGALVRDILAARLGVVL", "function": "Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.", "AFDB_id": "AF-D2NT85-F1-model_v4" }, { "swissprot_id": "A5D8S0", "sequence": "MAFCNTEYFDQIGNIQKIIHERERRRHELEETLFSYLRSDERLTRLKCAKMRCYAKELHEREQRAKTRNLELLGNVENLASKLKEFSIDCSRLLQKRMEYKNHITRLKKDRRKMGSRGKSEADEHPSRLSTQGLSQSAAIFMGHQTSNGSSRNDGATTKRLPSHTEQIPNHPSLPPSQSGLCMHSHVSKASGAGILSDDILNSGDFLEGRRLSDVREKQMESDWDISQRAREQQRQEELKSPHTTLKEAEVSSRSVTVNKPADIVSLEHCPTRSPSPDTTDPSDASHYMNSGGEDEEESAEDKDDSAPINQNHSDYTSNILKPDTSMHSDSDDSASQSQSGHHASRGNALIQEQSIKAMQTHCGSKHKKVSTWQSGQHHFSESPNRLSMKGFCHLLKCIEQRLETEDVVNLYRISVNEQNLSDDIISICSQRGRLDDIDLHACGAVVLQQLSMLSCSLPHGCLLPSDLINSHWSTTSKPQQIRLCLSAESAVLWDCCFTHMVQLQKQKLLSTDHIIQLFTPLLLPADATYTDKAGKLLKRLLTYKSETHYPSKSESSSSSSLPSLLNDSVEIKPARPSGTNAQTGEEQEIQSAEEDSADQSPVESIPIRETKAYQLLKQSVAQERHWSDSEEEVSEPPDAHKLEKPEVQQDILTQNNRKSVKTKPFSAVQSKAFWGESDDSNSEIEMALRPQSCNTSSHDFDDFYD", "function": "Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.", "AFDB_id": "AF-A5D8S0-F1-model_v4" }, { "swissprot_id": "Q8H1D2", "sequence": "MSFSVKGRSLRGNNNGGTGTKCGRWNPTVEQLKILTDLFRAGLRTPTTDQIQKISTELSFYGKIESKNVFYWFQNHKARERQKRRKISIDFDHHHHQPSTRDVFEISEEDCQEEEKVIETLQLFPVNSFEDSNSKVDKMRARGNNQYREYIRETTTTSFSPYSSCGAEMEHPPPLDLRLSFL", "function": "Transcription factor, which may be involved in the specification and maintenance of the stem cells (QC cells) in the root apical meristem (RAM).", "AFDB_id": "AF-Q8H1D2-F1-model_v4" }, { "swissprot_id": "Q55GF9", "sequence": "MDSIKKNTINRINGLPINHNNLSKTSIISMDDDYNSNSSFYSTNNSILNSVTKNSNYLNNNNNNNNNNNNNNNISISNCNNNNTNNKINEQLKTFNNIFEEKGEFLKEEIDNKFNDIISLMNQSKNQLFLSLNDIDSLYDLSPLSTTSTITLENNNNNNNNLIKFKLFNNDSIKKYILPVSSKTIKFKQRQILIEQQEFNEKHNQQKHLLELQRQQVLSDQQNQFQEQHKQQLSLKQQELEAIQQDTNKVKQQLIETHDKLLIEKEKQFKQDLNSLELNLQNKFTNEYQSKEQEFNKKLEQQQQQLEKQFQQTKELLIVQETLTLKSKLTTEFQEQLKTHQDQINKQELLLKQQEYQLFLKQQEISSIQKQHQDDLSSLKSKLSSDQDQIKKQLLQQESDLLKKQQELLLKQQELDIQSKQLKEEQEKQQQQQEKQQEKQQQQQPVVVPVKPTTSTVVSATTATLIKAPIVSTTTVSTATVSKLVTNGIAKPTPLTTMKQTVTAVPTLMDNKTRLKKLVPTATTTTTKEENNKEYDKMMQELDTQPNNSNLKNLNEKKLETLKQQLTFDDSVSFSNGNDESSINLSKYLEETNKSVENTFDIMSNTLKRKNEPIQQPSSSSSQLSSSQQPSSSSSSSSSSIGLKKRLSDDKTTIVTSKPTNKVQPQSLNSNINNNVVPPSPVAAIANKLKKQQELEKLKLEEEERLRKKQEEQLAKREVEKEQERLEKKKKNDEKRKKVEENQQQRILEEEKKKKEAEDRELARKHKEDSDKKKREEEEDAKKRIQERFRETQEQERKREEFKKQQQEQELARIKKEKLQQEKLQQEKEKQEKQKQQQQQQEEEQQKKKTVQTILPTPQTPSRSANNNYDDAANTASATKAKYALSSILSMVFGATKSPHFKPSTSQDDQDDDDCEDYDGTDENSENEAKGEYQDDSDQEIEEQFENDSDESMASTESNGDIYFNKNKNSNNSNNNNDVNQSRKDKSIVFDSDSLNRNHNDSNNSSEEEEPERDPVFLTPLPKILSNMKNNNNNNTYSNSPVIKGLSPPSSVSDYSPSSESNDCFSPLTPTNNNKINNNKINNNNSNNNSFNNSNSYRGLSPAQIIESHTPKCINRSGESKTSPFLTIRNTPSPLKNSPIKFNMSSASSLSSFDSDNDSDYNDNDIDDGEILGNPNENFTTPLKNQENNNNNNSNNSNTQYPIITSPPSNEDGDENYYFEEEEIDYEYDKRVPDWAKNHNLDNSLKQQRFYDPDRIFSMIGPVYLYEIFPKQDLGGKIKDFSKVKRNLSSDWSRDCNTEKEDISYKKNMGFTNPIIVNKK", "function": "Chromosomal passenger protein that seems to be required for chromosome segregation and the onset of cytokinesis during mitosis. Plays a key role in the abscission of daughter cells at the end of cytokinesis and in the establishment or maintenance of a bipolar spindle.", "AFDB_id": "AF-Q55GF9-F1-model_v4" }, { "swissprot_id": "F9USS8", "sequence": "MVLTDIEYLLSYLEAHHVPTIKKKRHTYLTYHGLAEHYTYVLKDGIIKNSIILQDGREYNLSYIAKPDVISLLRDEVSRSTDQPFNVRIESEYATFYQVNRVAFWKYVNSTPELQNYVKNYYRKKLSENILRLQRMVMNGKKGAICAFIYSLVDLFGRKVNEGILIDFVVTNDDIAGFCGISSRSSVNRMLKELRTDGVITVKNHKFIIQDVSYLLDQIAN", "function": "Positive transcriptional regulator that is absolutely required for the expression of lactate racemase (Lar) activity. Controls Lar expression by sensing the L-/D-lactate ration. Binds to a 16-bp palindromic sequence (Lar box motif) that is present in the larR-larA intergenic region, allowing transcription of the larABCDE operon.", "AFDB_id": "AF-F9USS8-F1-model_v4" }, { "swissprot_id": "Q9V9P3", "sequence": "MHKIVWFGTLNKSIGYIGKKKTCLLSPCEKICLNSARKTVQRCDKNYSPPKLRRIKNFYTYSVVLGSLFSIVMWAIYKLGKPEEDHRGPIEDEFSQLPWFRQYIMRMWHTLQYYEKMMEEPQMARLLPNVVPPPYIQPPYSLVLEIKDVLVHPDWTYQTGWRFKKRPGVDYFLQQCSRNFEIVIYTSEQGMTAFPLLDALDPYGYIKYRLVRGATDLVEGQHTKNLDYLNRDLSRVIVVDCDPYTTPLHPDNSLVLTKWLGNDDDVQLFDLTAFLQLIAEHQVNDVREVLRYYRQFEDPMEQFKDNQRRLQEQSQESIQNLPTSERQWNLTLLGRSLRGSSIK", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.", "AFDB_id": "AF-Q9V9P3-F1-model_v4" }, { "swissprot_id": "Q99523", "sequence": "MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGLRAAAAGGAFPRGGRWRRSAPGEDEECGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEANGVDGVDALDTASHTNKSGYHDDSDEDLLE", "function": "Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.", "AFDB_id": "AF-Q99523-F1-model_v4" }, { "swissprot_id": "G5EF60", "sequence": "MGRVSWIIALYLTINVVIVVNGDRVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMRGSERTRRENKFHGDDDAITVDDLWEAWFESIERTWTNERLVEWLINDVNLPSIVEAVKAKKIDGKILPRFASPNSDFLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNRTKDILLAFLALLLTSLIFLYVRQKQKAQQKVNELSNKLTELKCMETEFEDVQKMLNDERSKRSISDGVVNHTEMENLRVQLEEAERRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIEMVDRLQKKQGSVLSSLKLATGAASTSDQVDSKIFALKSRMEKIHTLTRETQERWLQIESLCGFPLLYLNETEHINRSIASSHFYNKSHEGSSSSGSISNAHSNPNAVNSNFVKKVSPPIPPSQQTANLRFVPTEQSDSIHSEDTSPIVEDVAISRSLTQDLAEADMQSIVSGSTNGSGSVAALKKRKGIFPKLFRRNTSKSSSLGGTSN", "function": "Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemostasis.", "AFDB_id": "AF-G5EF60-F1-model_v4" }, { "swissprot_id": "Q2W5N3", "sequence": "MAEPRYKADIGGGSLKLPESRIIAGLLLEGVTEDQWRHAIEVENVLQRRSPGTAKRQSSLMRNRLETMGPELWQMVRDGSTQVAIQAVFAAAIKHSTLLGDFLDLVVRDQFRMFRPDLPRKMWDQYLEQCRNRDPLMPVWQDSTANKLADCVYRILVEVGYITDSKTYRLKSVRISGEVMSYLRENNEQYVIRCIQVSI", "function": "BREX systems (bacteriophage exclusion) provide immunity against bacteriophage. Part of a type 1 BREX system which protects against dsDNA phage. This system allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA. Methylation of bacterial DNA by PglX guides self/non-self discrimination.", "AFDB_id": "AF-Q2W5N3-F1-model_v4" }, { "swissprot_id": "Q8ZT70", "sequence": "MLRVIGLGAVGSLFTYFLNRAGVVPEVVQRRRCGEFLFCVEGDCEKLKFREGGAADDVGYTIVAVKAYDSRSVVPHLKGVAVVAQNGIGGYEEIKEAYPNSVPAVVTYGVYREGCRAELRGVGEIYLPSAVSTLAELLERGGGRVRLVEDIEPYRWLKLAVNAAINAITALLQAPNGVIISSPYAQTLALEVAQEVLNVATALGVKMPRNPVEEVLRVASATAKNLSSTARDVAACAKTEIDYINGAVVKYGEALGVATPVNKALFNLIKARESLCNSG", "function": "Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.", "AFDB_id": "AF-Q8ZT70-F1-model_v4" }, { "swissprot_id": "A5H0J3", "sequence": "MTVDNPVSYFKSISSVRETTKQVFDYVEQNDGQGNHFKMELSKMDDVVDFLCSIIARDYGTDYSSIPPHGRWQHLNCGNVLRVESLIEQWSGAGIDEVEISRKLIDLFVFSVLVDAGAGNTWKYTTTEEGNKAFDRSEGLAVASYYLFVQGALSQDTNDKFKVNGKKLTELTMDEFCQGFQVSDANPLNGTEGRLKLIQNLGVALSTNPAIFGKEGRPGCLVDYLYSKCTKDNGTAVVDLNDVWNALMDGFTSIWPAGRTSIDGEPLGDAWVLDTKAKASGSDAFLDSIVTFHKLTQWLCYSLLVPLENYGYKFTIKNKDMQTGLPEYRNGGLFYDFGVLTLTDGAYKRGLALTQKLGDNSSKIPTFTPEDGAIVEWRCLTIGLLDYLLPLVNKKLDYDLVLPQLIEAGSWKAGREIAAIKRPDTKGPPIELHSDGTVF", "function": "Involved in uracil catabolism.", "AFDB_id": "AF-A5H0J3-F1-model_v4" }, { "swissprot_id": "P40099", "sequence": "MATKQLLRRQIKRVINALDYDIIAAESHTISQAVRSLIASANSRRVACYMSMDKGEVTTGEIIKNLFQDGQEVFLPRCTHTSESKHFKLREDHHPHLIFHRMSSLKMVRDLKPQGPYQLKEPEPHIEESDILDVVLVPGVAFDIKTGARMGHGAGYYDDFFQRYKILHEGQKPLLVGLCLMEQVASPIPLEKHDYSMDCIVCGDGSIHWFQ", "function": "Only enzyme known to utilize 5-formyltetrahydrofolate (folinic acid) as substrate. Contributes to tetrahydrofolate metabolism in an alternative way of folate biosynthesis. May regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.", "AFDB_id": "AF-P40099-F1-model_v4" }, { "swissprot_id": "Q54DY7", "sequence": "MMKLLFIIISIIFVINVSNSTPTLQLSGYFNVNETTNANLFYLFYESQNSPSTDPLILWLTGGPGCSSLMAAFYENGPYFVNDNLTLSENPNSWNMVANVLYVDSPLGAGFSYVVDSDGYSTTETEISENLYSFLTQFLSKYPKYSKLPLYIFGESYAGHYVPSFSYYIYQKNLGLATINLKGLAIGNGMVDPYIQYGSLGPFAYAHGMLDINALKETEGLYESCQQAIDSGDYNMTTQICNNIMDIVQEYAGNFNVYDVSKTCYPNEPLCYNFTAIIDYLNLASTKQSFGVLPNSTWNVCSTQPYSAIIRDWFNTPINYIPTLLENYKVLVYNGNYDWICNFLGSTEWTSQLKWKYNQEFNNSPRKILYINGNTISGYSQSYDNLTMQVLLGASHMAPREAPVAALAMVESFIQN", "function": "Probable carboxypeptidase.", "AFDB_id": "AF-Q54DY7-F1-model_v4" }, { "swissprot_id": "P44482", "sequence": "MKKIAFIGECMIELNGKPFAEMWQSYGGDTLNSATYLSRVSSSKEIQVHYVSALGTDNLSKQMLKYWQADGIQTNWVLQDEQHQPGLYLIQLDAQGERTFLYWRNQSAARYMVQHPDFAKVIAELQQVDVIYLSGISLAILPKNDRTFLIEQLSSLAKKGTEIVFDSNYRPKLWDSLEEAQDCYLQLLPSVNIALVTFDDEQALWKDKTSRDTLERLHKIGIPKVIVKCGKNGAIFSDRYLSQYGQVIPEPILNVVDTTSAGDSFNAGFLNGYLRNKSLEICCQQGNRIAGIVIQHKGAIIDKVAISHLQSEFN", "function": "Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG).", "AFDB_id": "AF-P44482-F1-model_v4" }, { "swissprot_id": "Q4FE47", "sequence": "MGQQQSKGELLYQQVSYGNSEGIRALHRDGGDLEWMDREGKTPLILACMNSELFDVAKTLIELGSNVNAYRPGRHAGTPLHHAAKRGLENTVKLLLSHGANPLVLNDDCQTPLEVARVKGFSNVVRAIEKHICLFSGWMREFYGPTFLDLFAPQLLSRRVWVVIVPTGSRNPTKPFKLELVVYASLQDAQPRTVMPLWKANLEEPKAKQSDTSVMIVDNSTIPSRRMKKRRVCASHGRRRPQVVRQTRLKFAPSTEGDSQQLKWFCDACKGIPQPMHPPVFLQAPPSAPPPPSEDGLAMGMNASLHTTMSDPSNLNHHSIGQASSSSGPSSSTAPPSGKASAFGFNSHGIGIVLESSPSAPPLTDDDIATVDDGPIHYPSIDSTPVDLPSAASLPASTEGERKEDGNTGTCAICLDAPSEAVCVPCGHVAGCMSCLKEIKSKNWGCPVCRAKIDQVIKLYRV", "function": "No E3 ubiquitin-protein ligase activity observed when associated with the E2 enzyme UBC8 in vitro.", "AFDB_id": "AF-Q4FE47-F1-model_v4" }, { "swissprot_id": "O31607", "sequence": "MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTETARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGLEGEIREFLFGRLELTARHMVNQTEAEDRSS", "function": "Hemoglobin-like protein that exhibits a low peroxidase activity. Its very high oxygen affinity may rule out the possibility that it is involved in oxygen transport.", "AFDB_id": "AF-O31607-F1-model_v4" }, { "swissprot_id": "Q94C48", "sequence": "MDPESIMAADGTDSAPANGGLAMENVCVKENGAVSVETVDTTSESQNENSANSSTLDTIEHVKEAAEGTQVEHVDDSKCMKGEKAQRKPRHEKLSGGKNNSSVHIKKSKEGKSADAKVAASNGSVAPNVQTTNPLKSKSFNGREAQVTKQGKHDSAPAESADGEKVKPKSQKKQAHETSEDDTQSSNSPKADDGKPRKVGALPNYGFSFKCDQRAEKRKEFYVKLEEKTHAKEEEINSMQAKSKETQEAELRMLRKSLNFKATPMPSFYQEPQPPKTELKKIPPTRPKSPKLGRKKTASGADSEETQTPRLGRLSLDERASKDNPTAKGIMPTVDLKKQPVRKSLPRLPSQKTVLPDGKPAPAKAAIIPAKVRPEKKKLEKDAETVNQTSHPTEEEAQVTVSSNADVEDSHETVSPRMNEDRADKSIEVSEAVAVEH", "function": "Microtubule-associated protein (MAP) that regulates the orientation of interphase cortical microtubules.", "AFDB_id": "AF-Q94C48-F1-model_v4" }, { "swissprot_id": "A6H757", "sequence": "MISRVFKLRMWAPVGVLTSLTYCLHQRRVALAEPGGADQQNPVDRNLLELKMVQVVFRHGARSPLKPLPQEDQQVEWKSQLLEVPPQTQLEYTVTNLAGGPKPHSPFDSQYHETTLKGGMFAGQLTKVGMEQMFALGERLRKNYVEDIPFLSPTFNPLEVFIRSTNIYRNLESTRCLLAGLFQRQKEGPIVIHTDEASSEVLYPNYQYCWNLQKRTRGRRQAASLQPGISEDLKKVKEGMGIASSDEVDFLVLLDNMAAEQVHSLPSCPTLKRFAWMIEQRAVDTALYILQWEDREGLQMAVGPFLHILESNLLKVVDPATPPSKTRKLYLYAAHDVTLMPLLMTLGIFDHKWPPFAVDLTMELYQHRESKEWFVQLYYRGKEQVPKGCPDGLCPLDKFLNTISVYTLSPEKYHMLCSEAQMMGLGNGE", "function": "Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.", "AFDB_id": "AF-A6H757-F1-model_v4" }, { "swissprot_id": "P12063", "sequence": "MLLRTKALIRSGGSIAKYAAANPSCFILQRRGLRREFGPKYTAKINEAEENWQARAEAIKKGKKQNTWDLFEERGYVKDTAGTKEHIAELMRTRRIGAYVGIDPTAPSLHVGHLLPLMPLFWMYLEGYKAFTLIGGSTAKIGDPTGRLKSRDHLSSSDATMNMTKIHYQLKKLWENVDTQMRARGYEADWARKRGIVNNNHWWNKQPMLEVLRRVGHALRIGPMLSRDTVKNKMTQGDGVSFAEFTYPIMQGWDWFELFYQQGVQMQIGGSDQYGNIISGLEVVKAARESEPDPQERKYVTPKTALDECVGFTVPLLTDSSGAKFGKSAGNAIWLDPYQTSVFDFYGYFVRRSDQEVENLLKLFTFMPISEITKTMEEHIKDPSKRVAQHTLAREVVTLVHGKQEASAAEDQHRMMYTGQMTIPQVSRAKDAATGGDQYKTISDQPVTLNNAPRIDMILPESLIMGKSIGRILYAAGLASSTTEGHKLAAAQGCYVGGAHRAGGENVTMNPDLISFMPVKLWFPGETQRYLINGNLLILRKGKHNVRVIQMVSDVEYAASGQTYPGQSFTGAVRKLNEIMKNLKEKKLTPEEAKNAVNELQKSSQEKQQGQQIIFPEEKSRQKKDMETKLKQEMIASVKTIDGMMDEKPSVRGDGVKKQTQDDRDPYKW", "function": "Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Has both an aminoacyl-tRNA synthetase activity and is involved in the splicing of group I introns. It acts in intron splicing by stabilizing the catalytically active structure of the intron.", "AFDB_id": "AF-P12063-F1-model_v4" }, { "swissprot_id": "A6QCD6", "sequence": "MVNQSKPEVAIFGGSFDPPHKGHQQIVRKAVQILDIDKLIVLPAYLNPFKNVSLANPEKRLEWCYQLFDGIPKVVVDDYEIRQNKSVRTSQSVKHFNNTYSVKYLIIGSDNLSTLTKWHEFKWLNDHITWVIVTRKGHPVQTEGLKSWRILEIDFPISSTTIREKKDLRYIDNKIKQSVEKTIKDKKE", "function": "Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).", "AFDB_id": "AF-A6QCD6-F1-model_v4" }, { "swissprot_id": "P52323", "sequence": "MSDLEKKYSKLIEGIITHLGDRKSLSFSELSNLLPDDILEPEILDCICSVLEDRGIRLVNKISELDLVVSEDGNDEEEEVEIESDRNFMILDDGFQSDEEDIDIDVKLDDCDEEDISVKDDLGSGYIKGNVLKDSHSEDPIKLYLKEIGKEFLLTGNQEVELAKQMDSGESIIENILKNEGLVIENYYNLVNTIYSRMEREEFFKREKDKDKESSPDYYNKKKRIASFYKIPLKPIQDRLISYVDNKHRVYDLGGDIFEKNLKKERLALKELLRDIPLYQEELRIFSDDYIDSANKIKDLQRQQRIILSRLKIEKIRDLRVLGRDLTIAEKKIEIEKSLKLKEDAIKEQITEAQLAQKELERIEMYYEYPTDKIISMSEEIAKGKQMMQHAKDQLIKANLRLVVSIAKKYANRGLHFFDLVQEGNIGLIKAVEKFEYKRGFKFSTYATWWIRQAITRSISDQARTIRVPVHMIEQINRLNRETRYLIQVLGKDPTDEELSDRLGWELKKVKTVKSVSREPVSLETPIGEEEDSVLSDFIEDKAIKNPANHTSFVVLQDQIRAILGTLPEREQEVVKMRFGLEDGYSLTLEEVGLHFNVTRERIRQIESKALRRLKNPKKTQKLKDYLEDLN", "function": "Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.", "AFDB_id": "AF-P52323-F1-model_v4" }, { "swissprot_id": "Q8KR68", "sequence": "MNFRRRLCTAALIAALPLASQAQNNTLLLNSVLAPQNPMTKMIVKPWAEKIAQVTEGRVKVDVAPSSLAAPQQQLASVNKGVFDIAYQFHGLLTDQVKLNQIAQLPFVNTTARGSSVALWRTYQKHFAKANELGEVQVLALFVQPPGVMFGMKGPIDGMDKLKGRKVYALPGVPSAMMESAGAAVVAAPGARSYEIVSGKTVDAFVGYPTSDAEGLKTLSYATDVTDIPGNLTAVSWVLFMNKKRWAALSEKDRKAIESISGEAFAQGMKQYDDLETKVRSEAAAKGIKFHMANDAFVKELQTLATPITQAWLKDASSRGVNGQEALDFYRAQAAANR", "function": "Involved in the uptake of p-toluenesulphonate (TSA). Forms a large, general diffusion pore with a preference for anions.", "AFDB_id": "AF-Q8KR68-F1-model_v4" }, { "swissprot_id": "P45068", "sequence": "MVKGVETKTIVGLEVGTSKVVVVVGEVFPDGVVNVLGVGSCPSKGIDRGSITDLDAVVGSIQRAIEAAESMADCQIMSVTLAITGEHIQSLNESGFVPIAESEVTQEEIDSALHTASSIKLPEGLSLLHVIPQEYAVDRQMNIKNPLGLQGVRLKAQVHLIACHQDWQNNLKKAVERCGLQVDKVVFSGFAATHSVLTEDEKDLGVCLIDFGAGTMNVMVYTNGALRFSKVIPYAGNIVTNDIAHACTISRAEAERIKVNYASAFYPARLHGDKKIEVASIGGRAPRSLTKSDLSLITSARYTELLGVVKDELDKLKAELEAKHIKFELIAGVVITGGGAQIEDLKECASNVFHCQVRIASPLNITGLTDYVNRPQYSTVVGLLQYNYSNSDDDLISGSDDSEGTFFESIWQGVKKIVNKVRSEF", "function": "Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.", "AFDB_id": "AF-P45068-F1-model_v4" }, { "swissprot_id": "Q9VGH1", "sequence": "MTEKRERPGPLRWLRHLLDQLLVRILSLSLFRSRCDPPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAAGGATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFGTSVLTCPKIQSSLDYFTQIVHKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIIDHCIRVQEDQRRPHDEALYHRLQAADVPGDMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPRLQQRLAKERATNDSRLMHGLIKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLRLALRPRTE", "function": "Required for CNS development: midline glial cells. Involved in the metabolism of insect hormones: responsible for ecdysteroid C2-hydroxylase activity. May be involved in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9VGH1-F1-model_v4" }, { "swissprot_id": "Q8K368", "sequence": "MDLKILSLATDKTTDKLQEFLQTLKDDDLASLLQNQAVKGRAVGTLLRAVLKGSPCSEEDGALRRYKIYSCCIQLVESGDLQQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDRLVNGKSLELLPIILTALATKKEVLACGKGDLNGEEYKRQLIDTLCSVRWPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLTMFSKLNLQEIPPLVYQLLVLSSKGSRRSVLDGIIAFFRELDKQHREEQSSDELSELITAPADELYHVEGTVILHIVFAIKLDCELGRELLKHLKAGQQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKDLQLLQGSKFLQTLVPQRTCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSYGPKKILDGKAVEIGTSLSKMTNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLILQNCSKVTETFDYLTFLPLQTVQGLLKAVQPLLKISMSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKVLGSLPSSQCTQSIGVTQVRVDVHSRYSAVANETFCLEIIDSLKRSLGQQADIRLMLYDGFYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGACVLTQGSQIFLQEPLDHLLSCIQHCLAWYKSRVVPLQQGDEGEEEEEELYSELDDMLESITVRMIKSELEDFELDKSADFSQNTNVGIKNNICACLIMGVCEVLMEYNFSISNFSKSKFEEILSLFTCYKKFSDILSEKAGKGKAKMTSKVSDSLLSLKFVSDLLTALFRDSIQSHEESLSVLRSSGEFMHYAVNVTLQKIQQLIRTGHVSGPDGQNPDKIFQNLCDITRVLLWRYTSIPTSVEESGKKEKGKSISLLCLEGLQKTFSVVLQFYQPKVQQFLQALDVMGTEEEEAGVTVTQRASFQIRQFQRSLLNLLSSEEDDFNSKEALLLIAVLSTLSRLLEPTSPQFVQMLSWTSKICKEYSQEDASFCKSLMNLFFSLHVLYKSPVTLLRDLSQDIHGQLGDIDQDVEIEKTDHFAVVNLRTAAPTVCLLVLSQAEKVLEEVDWLIAKIKGSANQETLSDKVTPEDASSQAVPPTLLIEKAIVMQLGTLVTFFHELVQTALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVCQSSRGIPNTVEKLVKLSGSHLTPVCYSFISYVQNKSSDAPKCSEKEKAAVSTTMAKVLRETKPIPNLVFAIEQYEKFLIQLSKKSKVNLMQHMKLSTSRDFKIKGSVLDMVLREDEEDENEEGTASAHTQQDREPAKKRRKKCLS", "function": "Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.", "AFDB_id": "AF-Q8K368-F1-model_v4" }, { "swissprot_id": "Q06098", "sequence": "MNSTPPTSPVTRVSDGSFPSISNNSKGFAYRQPQKHKSNFAYSHLVSPVEEPTAKFSEAFQTDYSSKAPVATSEAHLKNDLDVLFTTPRFYSPENLALMFRLSNTVSSLEFLDEFLMGILLAPEMDFLSNPSYSLPSNKLVGQGSYSYVYPISSSASSRCNNDSGVVLKFAKSQHKSKVILQEALTLAYLQYMSPSTNESHIIPFYGLTYITKSHFRRLRSNECVPGLILPKCEMSLYHFNTAVSHKLSLITKRKIWWRLMKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPTDLNTTVEYCAPELIDSSSDHVPTFESDLYAVGLCLLSFISQHEPYNELQALVSHGSSPGIGSSSIQQSQWLINALLKKDPINLNMLRNDLFQDWKSELALLSRILVDRLPLENLITILDSNYI", "function": "Probable serine/threonine protein kinase which may function redundantly with MPK1-independent branch of the PCK1 pathway that is presumed to be required for the tolerance to high temperatures and staurosporine.", "AFDB_id": "AF-Q06098-F1-model_v4" }, { "swissprot_id": "Q8ZBL1", "sequence": "MVQQAVIQRSANQRATNQPTEYIGRFAPSPSGDLHFGSLIAALGSYLQARAQGGKWLVRIEDIDPPREVPGAASRILAALEHYGLHWDGPVIYQSQRHEAYRATLNWLEQQGLSYYCTCTRSRIHQLGGFYDGYCRDRHLPASGAAIRLRQTQPVYAFYDKLLGELHAHPALAQEDFIIRRRDGLFAYNLAVVVDDAFQGVTEIVRGADLIEPTVRQIALYQQLQHPVPGYIHLPLALNNQGNKLSKQNHAPPLPNGDPRPILIDALKFLRQPLPEYWQDLDLYLLLRYAVKHWTLVSIPLQGAITPQKTQRHSQSKYGEL", "function": "Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.", "AFDB_id": "AF-Q8ZBL1-F1-model_v4" }, { "swissprot_id": "Q5SK48", "sequence": "MRGIRDPRLIPIAEKVMEGKRLSFEDGLVLYQTKDLPTLMRLANLVRERKHGHKTYFVHSIRVSQTNICYVGCTFCAFQRRFGEEGAWDWDVDEVVAWVKERYQPGLTEIHLTAGHHPKRPFAYYLDLVRALKENFPGVQVKAWTAAEIHHFSKIARLPYREVLKALKEAGLDAMPGGGAEIFAERVRRKIARAKVSAEGWLEIHRTAHELGIPTNATMLYGHIETLEERLDHMDRLRRLQDETGGFMSFIPLAFQPDGNQLARELGKKEFTTGLDDLRNLAVARLYLDNFPHIKGYWATLTPELAQVSLDWGVTDVDGTLIEERIVHMAGSPTPQGLTKRELARIILMAGRIPVERDALYREVRVWDRVEA", "function": "Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.", "AFDB_id": "AF-Q5SK48-F1-model_v4" }, { "swissprot_id": "Q5N897", "sequence": "MPTLRSATASASTAGTASPTAIATPRSAKRRLTSPRRAAGSPDASQFTSPHKSPNVGIVGTPKLLSASPRSSRKRLYGDFVAAEKPKWNPRGKSPESHFSRAQSSDWDLTKEFICSADPAQMQVVKEALHVATVPSCGLVCRDDEQSRVLEFCKGCVEQERSGSLYVCGCPGTGKTLSINKVKESVARWADETGMETPDALSINCTSLAKTHEIFSKILAKFQTRKKATCKLSPLQQLQTMFSHKESAPRRMLLVVVDEMDYLITRDRAVLHDLFMLTTYQFSRCILIGIANAIDLADRFLPKLESLNCKPLVVTFRAYSKDQISDIIKHRLKVLEYDVFEPLALEFCARKVAAASGDMRKALGVCRSAVEVFEARLQESSDQEFGLVTFDHMDIALSKAFKSPVVDSILCLPQHQQMVLCALANTFHHCKKKATTLGELNKSYIEICRSTQVPAVGMLEFSNMCMVLSDQGFMKLGQSKEDKLRRVMLQIDSSDITFAFKGNRFFQKCLEQQKF", "function": "May be involved in the initiation of DNA replication.", "AFDB_id": "AF-Q5N897-F1-model_v4" }, { "swissprot_id": "B7FXE8", "sequence": "MKTWNDGKTIAIERCVLPLDASLHKGSSGRVGVLGGSARYTGAPYYAAMASLQAGADLAFVFCAQEATLPIKSYSPELMVAPVYSASDFDPVRLVDDMVNEIGDMLPKLHCLVVGPGLGRCPLVMKAVARVLELARSQQLHLVLDADALYMMSLPVYRSSLKGYDRLVLTPNVVEYQRLFPKSEDNNGESMEDASDEELAAATIVRKGAEDRIIVDQRQVMSCGEEGGLKRSGGIGDVLAGTLGTFTSWHAILLDREAVSTEDLPLSCWTACCAVKRATKRAFDDKRRAMTAPDVLHHLGQALDEMTRED", "function": "Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.", "AFDB_id": "AF-B7FXE8-F1-model_v4" }, { "swissprot_id": "O60057", "sequence": "MLAQNSREVLDKDLESHIPGAYSPAPPSSSLPTQNESNLQQSEKPLKHFENKKFKGEDVFAHSISKPFDGQNDEEKPSLYSHLTNELYETHDSSDYFGTYMEREESGHDEEEADKDASFTGYYNSRNNDEEGSELADSQMLPMTESFADIEDIHHHQHEDEFSSSNKDKGFTYEKPVTELPPKRPPYHYESSSTSISFVNGGPNFRKVKSGLLKPDADAASNLSTTSLVNQEYVMKQVTPNEYSMEYLRESFPQTPMGTEASGYSFDRTPHKSDIQASDRLNALNEKLLQGIQQSHQPYHYTNVKDSQGSHQTKVTIEENMEAPSHQAANRTTLTDSPLGIVEDETTILTDLEPSGPGLQKRASETSMSTNVSLPYYQNGRRVRNILTPYPTVSLASTMTSETEDVSEERI", "function": "Has a role in meiosis.", "AFDB_id": "AF-O60057-F1-model_v4" }, { "swissprot_id": "Q8SUF9", "sequence": "MSEIGSSVPVNENRPLLTEDEVEAQANSSTVWPLSRIRVARCEWKLWGSLAFIFGASAYIYSFSRVMKDSFVLSRQLPIAISFLKTCFVLPISVIVTGIVQKLLVTRTISKVFDYTLIAFSFLYLLIGMVLLPFAEKIQPGLYFSRDIFADDKMAYKGFEFLFAIFLIFNEWTTSFVYVCAELFGSLVVQFMFLAFANEALTIRQSTRMMPLFYVISNILLLLSSESTSFYSKKVREWDYKKTCLITNSFFAVFGAMIAVTYLVKKYAENTILKKQLFIRTEGVAKKKGRKSSAGFSESMKLMAQSKFLVAMVMNALFYYAGTNLIESSWKNGISVAADANNMEKRAYSASIVSGEQRVVGALVAIILLTPISTLVQTHGWITMAIVPPLVTLVSSLVIFGSAFFNYSNYPEGKTSVILSSLVKGYKPNFYLECNIGIYCVSGMKIAKYAFYDISKEAISLQIDPLYRPRLKAVYDGLCGKLGKSIGSLYAMFWSVMGYNDVRAAAPITLGMWLIISPIWIYSVIYLNRKYNQSIQTSSPIDLDLFSGKKDLE", "function": "ATP transporter involved in the uptake of ATP from the host cell cytoplasm. Provides the microsporidian cell with host ATP in exchange for ADP. This is an obligate exchange system. This energy acquiring activity is an important component of microsporidian parasitism.", "AFDB_id": "AF-Q8SUF9-F1-model_v4" }, { "swissprot_id": "Q5RAQ1", "sequence": "MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCGKRLKEVLQRPADIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTDSRYRGRPCLPEWDHILCWPLGAPQGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVQFLTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLHFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPATAAPKDDGFLNGSCSGLDEEASGPEQPPALLQEEWETVM", "function": "Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.", "AFDB_id": "AF-Q5RAQ1-F1-model_v4" }, { "swissprot_id": "P31377", "sequence": "MDVLKLGYELDQLSDLVEERTRLVSVLKLAPTSNDNVTLKRQLGSILELLQKCAPNDELISRYNTILDKIPDTAVDKELYRFQQQVARNTDEVSKESLKKVRFKNDDELTVMYKDDDEQDEESPLPSTHTPYKDEPLQSQLQSQSQPQPPQPMVSNQELFINQQQQLLEQDSHLGALSQSIGRTHDISLDLNNEIVSQNDSLLVDLENLIDNNGRNLNRASRSMHGFNNSRFKDNGNCVIILVLIVVLLLLLLVL", "function": "t-SNARE which may play a role in determining the specificity of membrane fusion, protein transport and vesicle trafficking within the Golgi/endosomal and plasma membrane/endosomal systems.", "AFDB_id": "AF-P31377-F1-model_v4" }, { "swissprot_id": "O26776", "sequence": "MLLTTSRKPSQRTRSFSQRLSRIMGWRYINRGKMSLRDVLIEARGPVAVVSERHGNPARITFLDERGGERGYILFNPSFEMKKPELADKAVRVSSCPPGSEGLCNLMGLEVDESSSRDAWSIRTDEEYAWVMELMDARGTPAGFKLLIRDFRVGE", "function": "Probably involved in the biogenesis of the ribosome.", "AFDB_id": "AF-O26776-F1-model_v4" }, { "swissprot_id": "Q9AST6", "sequence": "MADVPGYLRTCLDMGKIAFLAILVSTGIVLQILACALFNNWWPMLSVIMYVLLPMPLLFFGGSDSTSLFNESDNSWINAAKFLTGASAVGSVAIPSILKHAGLIGWGALALDLSSYVVFLVAILGYICIGDASDNYYSYI", "function": "Involved in endosomal protein transport.", "AFDB_id": "AF-Q9AST6-F1-model_v4" }, { "swissprot_id": "Q73RJ5", "sequence": "MNNLFSILHNTPLFQEGTIEFYKPLKPLTSYKIGGPAEALFCPKDEDHLKEALIFLSKNKISASLIGGGTNILVSDKGFRGVLISLKNLNKIEIIGESENKVFVRAGAGVLTDKLTKWAVENSLSGLECFGGLPGSVGGAVFMNARCYDVSISDRLKSIKYILADGDKTEFAEYEYNPSDWDYKASPFQQNPVSTEITKNRKIVLSAVFTLTHGIKEEIAVKTEEKVQDRISKGHFKEPSAGSTFKNNRAFGLPSGKLIEDAGLKGLCEGGAQVAPWHGNFIINKHDASASDIKTLIEKVQKTVKDKTGFLLEPEVIFAGDWG", "function": "Cell wall formation.", "AFDB_id": "AF-Q73RJ5-F1-model_v4" }, { "swissprot_id": "P11916", "sequence": "MCAKSLLLVFGILLGLSHLSLSQNWATFQQKHIINTPIINCNTIMDNNIYIVGGQCKRVNTFIISSATTVKAICTGVINMNVLSTTRFQLNTCTRTSITPRPCPYSSRTETNYICVKCENQYPVHFAGIGRCP", "function": "Preferentially cleaves single-stranded RNA at pyrimidine residues with a 3'flanking guanine. Hydrolyzes poly(U) and poly(C) as substrates, and prefers the former. The S-lectins in frog eggs may be involved in the fertilization and development of the frog embryo. This lectin agglutinates various animal cells, including normal lymphocytes, erythrocytes, and fibroblasts of animal and human origin. It is cytotoxic against several tumor cells.", "AFDB_id": "AF-P11916-F1-model_v4" }, { "swissprot_id": "Q54VS7", "sequence": "MIITTSNDEDKKTNVFVELAAGSFSGALTRFIVAPLDVVKIRLQLQRTQLNNNSNNNNKIIGKENVNYRGIINTMSKVIREEGIRSLWKGNFSAELLWVTYAAIQFSTYNEIIGILDPEYRKHQQRTDKDKPNYKPSSSITMIGGASAGILSTIVSYPFDIIRTNIVNNHNKTNFKQTFKTIIARNGGYSNLFSGINSSLFQIVPQMGFQFTFYETFKFISNKYTSSVNNNNNNPLNQFTCGLLSGAISKFLVLPFDVVKKRLQVNEKVGYGMKSCFRDLYFNEGGVKAFFKGGTPGIVKAGLAAALSFTFFEQSKRILLNKQ", "function": "Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.", "AFDB_id": "AF-Q54VS7-F1-model_v4" }, { "swissprot_id": "P40145", "sequence": "MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP", "function": "Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.", "AFDB_id": "AF-P40145-F1-model_v4" }, { "swissprot_id": "Q63661", "sequence": "MRGPHGVSWRVPWLCLSCLCSCLLLLPVNTSTTSAPKTSTALPSSTNPSQMTSQVSNPTASSYRMTKNTGQASPMVTSSSITTLPQSQHTGSMKTTRNPQTTGTTEVTTTLSASSSDQVQVETTSQTTLSPDTTTTSHAPRESSSPPSTSVILTTTASTEGTSGDTGHTMAVTTQGSTPATTEISVTPSTQKMSPVSTFSTSTQEITTLSQSQHTGGMKTTRNPQTTGTTEVTTTLSASSSDHPTSSPESTPGNTAPRTTETSTTTTTKVLMTSLQQKLPTGSTLGTSTQELTTLPQSQHTGIMKTTSRTQTTTPTEVTTRTLSASSSDHRQAETSSQTTLSPDTTTTSHAPRESSPPSTSVILTHGHREGTSGDTGHTMAVTTQGSTPATTEISVTPSTQKMSPVSTFSTSTQEITTLSQSQHTGGMKTTRNPQRTTPTEVTTSTLSASSSDQVQVETTSRATLSPDTTTTSHAPSVSSSSPSPPSTEGTSVDTGLTTAVTTQDSTPATTQGSLTSSSQTLSTVSPLSTSTQETSTQELTSSQSQHTGSMKTTHNPQTTRNTEVTTTLSASSSDQVQVETTSQTTLSDATTTSHAPRESSSPPSTSDILTTMASTEGTSGDTGHTMAVTTQGSTPATTEISVTPSTQKMSPVSTFSTSTQEITTLSQSQHTGGMKTTRNPQTTGTTEVTTTLSASSSDQVQAETSSQTTLSPDTTTTSHAPRESSSPPSTSDMLTTTASTEGTSGDTGHTTAVTTQGSIPATTQLSTTFASQKMSTVSTPTTSSIQELSTLPQSQHTGSMEISSRPQTTSVTSTLSSSPSGSTPVQTRSVTSSSDERTNPTSSGVSNTSPATTEVLTPTSSPESTPGNTAPRTTETSTTTTTKVLMTSLQQKLPTGSTLGTSTPTEVTTTLSASSSDQVQVETTSQTTLSPDATTTSHAPRESSSPPSTSVILTTMASTEGTSGDTGHTTAVTDQGSTPATTEISVTPSTQKMSTVSTLVTSTQELTSSQSQRTGSMGTSSKPQATTPTEVTTSTLSSFSRGSLFSARNCCLQTKKPPLPAVVCLPDPSSVPSLMHSSKPQATTPTEVTTSTLSSFSRGSTQTQTVSWETSSSGKITAPSTSSRRTPSVATSDIFTTTDSTSGNAGHTLLTGSHSVITSRVASTTLGRLSTVAHRQSTQRSSTHSQSYLTESMGASSTSETSLLTEATTETSLCLFTWTHCDRDLLSWTSSSGLTTKTDNDRSTALSATSLTLPAPSTSTASRSTVPPAPLPPDQGISLFQIGFPLGSLCGIPSILQITVRSFSPSQTTMSSPTPTHLKEASQEGSVCHSGHSGVMLISLAPGEPYFRTTTSHFTMSSTSLIRKVESLINEFTSDWSFKPSDTEVTWVNVPAYPAQGRTLGANTYQAILSTDGSRSYALFLYQSGGMRWDVTQGLYNRVLMGFSSGDGYFENSPLIFRPAVEKYRPDRFLTPNYGSGDSRSTGYTGRCGPTTGSSVCSGWKVSLSSPAGAGTRFPALAPGSRDFGSGSSTQVCGAGSYAASLRAGRVLYVWHLGEFREGWRMHSPWQFDEDEGRHRTGLAAGTTSPLSASSTSSGGPELVVLGTRPPRPAWTFGDPHITTLDNAKYTFNGLGYFLLVQAQDRNSSFLLEGRTAQTDSANATNFIAFAAQYNTSSLKSPITVQWFLEPNDTIRVVHNNQTVAFNTSDTEDLPVFNATGVLLIQNGSQVSANFDGTVTISVIALSNILHASSSLSEEYRNHTKGLLGVWNDNPEDDFRMPNGSTIPSNTSEETLFHYGMTSETNGIGLLGVRTDPLPSEFTPIFLSQLWNKSGAGEDLISGCNEDAQCKFDILATGNRDIGQSTNSILRTFRHVNGTLNQYPPPIHYSSKIQAYKGREQWPLRSPATLRMSYSASPTSAVAFELFENGSLHVDTNIPRRTYLEILARDVKTNLSSVLQPETVACFCSKEEQCLYNETSKEGNSSTEVTSCKCDGNSFGRLCEHSKDLCTEPCFPNVDCIPGKGCQACPPNMTGDGRHCVAVEISEFCQNHSCPVNYCYNHGHCDISGPPDCQPTCTCAPAFTGNRCFLAGNNFTPIIYKELPLRTITLSLREDENASNADVNASVANVLENLDMRAFLSNSLVELIRTSPGAPVLGKPIHHWKVVSHFKYRPRGPLIHYLNNQLISAVMEAFLLQARQERRKRSGEARKNVRFFPISRADVQDGMALNLSMLDEYFTCDGYKGYHLVYSPQDGVTCVSPCSEGYCHNGGQCKHLPDGPQCTCATFSIYTSWGERCEHLSVKLGAFFGILFGALGALLLLAILACVVFHFCGCSMNKFSYPLDSEL", "function": "Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.", "AFDB_id": "AF-Q63661-F1-model_v4" }, { "swissprot_id": "P40794", "sequence": "MSISTFNFQFYNYKLSPSSPGFGSTASRSSSSCISELEMDIDEDMSAQPTITSTPKPRFTSQLAVELAKTEPGNGISPLRPKLHTAQKRWSMELREKVLEMSKRNNGQEKPQTARQQEQRQPQEQPLQQEELQHQQQEPTVTDKINFFNKLTNTFESGFSKLMPQASSTNNRFIAMLRTARPQNVATTTANSSTANSFLGSDHSLSGSVTGQVPPPKPKRLSATTAQFATPHVPAMGVGKGGSQRKCSLRRKPSMDKSRATISRQSSSASVRTQNHAIMEDLSLVVPVRLRIAEYEQRISMSA", "function": "Acts as a regulator of the microfilament network governing cellularization of the embryo. Determines the timing of a key conformational transition in the cortical microfilament network: the proper coordination of membrane invagination and basal closure of the cells. To do this, bnk possibly physically links neighboring contractile units of the early cycle 14 microfilament network in a manner that prevents basal constriction until the proper stage has been reached. Bnk together with nullo and Sry-alpha may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.", "AFDB_id": "AF-P40794-F1-model_v4" }, { "swissprot_id": "P0DMJ8", "sequence": "MATRFAILPVTALITLTAQAQQAPTPNDQAAAARANAEQNQQAQQRRDAQQRDATVQAPGVRSDVPRPEAYPVLPTETPCFQIDRFALDVPDSLPAASKAQGASALPMDRFAFARDWLAHYAGQCIGKQGVDLIVKGLSQAILARGYITTRVLVPEQDLSTGALKLALIPGVIRHVRFEDEKLLGTWKTAFPTRDGDVLNLRDIEQGLEQMKRVSSQDVSMRIAPGDMPGESDVVLDVKRGKPWTVVASIDNSGTRATGKLQGNVSLGIDNPLGLNDIFNVGFNQDLEFGDKRFGSHGWNAFYSIPWGYWTGTLSAYTSTYFQPLAAVNQTFVASGNMKTVDFRLNRVLTRSRNDVLGAQVRLTRRFGDSYIEGTTIPSSHQNATFLEFGLNDRHYFGSSQFDGSLAYRQGLGWLGSTDSMFAAEGGQTYRFKMVVLDANLSTPFVIGTQPFKYVTTFHGQYTGNTVSYLDSVTIGSRYTVRGFDGETLLAGSRGFYWRNELQVPVAQTGLSAYAGLDYGRVWGPEPVALVGTQLAGAVIGVKGSLMTRFGGYGYDLFAGTPVYKPSGFPTARVTVGFQLTAQF", "function": "Probable member of a two partner secretion pathway (TPS) in which it mediates the secretion of CdiA2.", "AFDB_id": "AF-P0DMJ8-F1-model_v4" }, { "swissprot_id": "P51690", "sequence": "MLHLHHSCLCFRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ", "function": "Exhibits arylsulfatase activity towards the artificial substrate 4-methylumbelliferyl sulfate. May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.", "AFDB_id": "AF-P51690-F1-model_v4" }, { "swissprot_id": "Q9XXD1", "sequence": "MNSAIMQGAAMATSHGIARLNRHNAQRNHFHIPTANRLFYQLQTPCTSTEEERRTVQTDDVAEIGMQRPDYQMYCGEEEISEQFVKLNVGGQRFMLRKDTIRRRGVGRLLDLINKPVADSNADAFFSSTSEFYFERPPSLFHIVYQFYLNGVIHQPSNLCPVDIIEELEYWRIIPDQYLASCCCAQQIDDDDEEVEEQDKPNLFKTLRFGEIRRCVWNIIEEPASSGKAQAFAVCSVVFVLISISGLVLGSLPELQVATKQRNNLTGEEFTEMEPMPILGYIEYVCIVWFTMEYGLKMLVSAERSKTFRQLLNIIDLLAILPFIIEMLLLIFGISTEQLRDLKGAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKTLKASFRQLGMMAMVVMTGVIFFSTLVYFLEKDEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPGKLVATGAIACGVLVLALPITIIVDNFMKVAETERPAGGNRYRTSQYPKATKSEQMILKVT", "function": "Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.", "AFDB_id": "AF-Q9XXD1-F1-model_v4" }, { "swissprot_id": "Q7CPI8", "sequence": "MMTISDIVQIILFCALIFFPLGYLARHSLRRISDTTRLLFAKPRYVKPAGTLRRATKVKADKK", "function": "Required for cellulose biosynthesis.", "AFDB_id": "AF-Q7CPI8-F1-model_v4" }, { "swissprot_id": "Q7D3B2", "sequence": "MKIAAIGGGVIGGGWIARFILAGHDVTVFDPHPEANRIVTEVMANAAEAWGRLYQSPLPKPGSINWASSIAEAVAGADYIQESVPERLDLKHRIIAEIEATASPQAIIASSTSGFKPSELREGSVHSERVIVAHPFNPVYLLPVVEVVGGGVAAQRASDILVSVGMKPVQIGREIDAHIGDRLLEAIWREALWLVKDGIATTQEIDDIIRYGFGLRWAQMGLFETYRIAGGEAGMRHFLAQFGPALKWPWTKLMDVPEFNDELIDLIAGQSDAQSGAYSIRELERIRDSNLIGIFHALKANDWGAGQTVKAMENRFYARNGKVQADYPLRLHEAHVNGGWVDYNGHMTEFRYLQVLGDATDALLIHIGLDADYRAAGHSAYTVETHIRHLAEVKAGARLTVETRLLGYDDKRLRLHHAILNEDGETVATGEHMLLHVDTKANRTVAMPPALMRALDHLNAQEEGPLPDHAGSGIRAVRLKETSA", "function": "Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.", "AFDB_id": "AF-Q7D3B2-F1-model_v4" }, { "swissprot_id": "Q9URT4", "sequence": "MMEKSLNTVTSLPLRVIYCIDRASAIRCLAKSQHAVPIQVLKEVEPKKVICQVDIQHVIQTVCRCSPELSCKSQGDFSVYFLDHTEPDELFVGLGYWSSLLLSPTLNAGTSNSDTVWVNGFIVEFGIQRSIEIKLRFQSLQNSFEVGTPETHTSSKFLSSTLPPSLIFDPSSSEKSDSISGSLFDTNYTCPVNINGLSKQKSVRELKSPSRPSALAETNVEELELDSLFHASNDISCSATSFSEPYILDHQAALDHPATDPVCSASSTTVNSAVSTKKRRRESSTISPESAYVAAQLQNPSEREQVHEFIKEQVRIARGRIEKKFTNVRGKNRIEEQLTLSLQEGKIPPYCQNCGTIKTANWRNATYMNITLMLCNACGIYWTSRRSMRPRNLWSTYKAFETEKPLENDAFAQLELAVYKLSQQRKLSISIFRELENAGRHSPLNRLTSLDSTHSAPDPNHISKPSVVNQQKSRGGPRTAKLKNDLRRIQSSPIVAPTPDTSFREPLSEIGSNDSWLVLPNSLSANIQNDVLRKTDFMCTDKENVAFPLKTTTKPMPKVNKEETEPTLPVCDSEKENDDLECYFRTPPKPTTLQKQQQSPSPWRSELFLSDPDQNVLTPRHKPKFDLSKALSSVAKSNNIENSPQLPERYDFSLELGLNSQLDNEERRDIPLMTDLVMPSSPPMVPADRHLSVENTC", "function": "Required for proper chromosome segregation via regulation of CENP-A localization to the centromere.", "AFDB_id": "AF-Q9URT4-F1-model_v4" }, { "swissprot_id": "Q8L960", "sequence": "MASVAASSSISFAASFLKIKAFPLSPRFFPIRTLRCSVSSSSSEPIEFDISFAPPKPKPSSTHGGVTPQQLFIPWIVRSDDGTLKLQSQPPARLIHNLAIDATTQNPKKKDKSKKKQPQATSSSSATTTASSPASHSEVKPKLSKAARRFYNENFKEQPQRLSKVLAAAGVASRRTSEELIFDGKVTVNGILCNTPQTRVDPSRDIIYVNGNRIPKKLPPKVYFALNKPKGYICSSGEKEIKSAISLFDEYLSSWDKRNPGTPKPRLFTVGRLDVATTGLIVVTNDGDFAQKLSHPSSSLPKEYITTVVGDIHKRHLMAISEGTMVEGVHCVPDSVELMPKQHDIPRARLRIVVHEGRNHEVRELVKNAGLEVHSLKRVRIGGFRLPSDLGLGKHVELKQSELKALGWKN", "function": "Responsible for synthesis of pseudouridine in chloroplastic 23S ribosomal RNA (Probable). Necessary for normal chloroplast rRNA processing and translation. Required for normal chloroplast development and maintenance. May function in other plastids, such as root amyloplasts.", "AFDB_id": "AF-Q8L960-F1-model_v4" }, { "swissprot_id": "Q9R1S4", "sequence": "MVVVAAAPSAASAAPKVLLLSGQPASGGRALPLMVPGPRAAGSEASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLQLENQLLREKTHGLVIENQELRTRLGMNALVTEEVSEAESKGNGVRLVAGSAESAALRLRAPLQQVQAQLSPPQNIFPWILTLLPLQILSLISFWAFWTSWTLSCFSNVLPQSLLIWRNSQRSTQKDLVPYQPPFLCQWGPHQPSWKPLMNSFVLTMYTPSL", "function": "Acts as a weak transcriptional factor. Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress. Binds to the ER stress response element (ERSE) upon ER stress. Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences. Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner. Binds to the CDH5/VE-cadherin gene promoter region.", "AFDB_id": "AF-Q9R1S4-F1-model_v4" }, { "swissprot_id": "Q6EAL8", "sequence": "MIFHTGTTKPTLVLLCCIGTWLATCSLSFGAPISKEDLRTTIDLLKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENTVDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDNTTC", "function": "Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages.", "AFDB_id": "AF-Q6EAL8-F1-model_v4" }, { "swissprot_id": "B9DMC7", "sequence": "MKIQDYTKEMVDEKSFIDMAHTLLEEKGTTMNLYDIIDEFKALGHYEDDEHLENRIVQFYTDLNTDGRFLNVGENNWGLRDWYSVDDIEEKIAPTIQKFDILDEDDEEDKNLKLLGEEEEEIDDQETAEADAEDDDEDLDDPQDEEEINDSDIVIEEDKDEMDEAEQLFEEEEDFNDDPDDDKI", "function": "Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.", "AFDB_id": "AF-B9DMC7-F1-model_v4" }, { "swissprot_id": "O74450", "sequence": "MKKKQTKVKQTVKLVLRNPLSISWPIVDANTQEKLAQTLVQWLPASHKDILDSKLTVGLNSVNELLERCCQNAKDVTQPAVVFILHDQDSMLVTHMPQLVANANFYGSSKCRLVPLGFSAQALIAKKLGLSRAGAIAVQDDSPLWKYLKDLVMNIEEPQARWLSENPEYEVTKVEKIITSQKENQGTKKEGKNEKGNEFKK", "function": "Required for processing of 5.8S rRNA (short form) at site A3 and for 5'- and 3'-processing of pre-tRNA.", "AFDB_id": "AF-O74450-F1-model_v4" }, { "swissprot_id": "Q5A4F3", "sequence": "MAKKKLNSTIKRSRTRSGCVTCRDRHIKCDEQQPVCKNCQKSNRKCYRGIRLNFTQYTFYNPDDNKPKELQQNEQPNSSHYAFPNLEPNPVSQKHRILDQSITIASLYDDLKKYKPYIHLHTPEDLRESDLQFQEDTYNSYISTSAINLRGKKLTKRDPGLSTSLSVINPTLESEIKPNPVILNQLSFHPPPNLNTGVLYPPTATAATTTTSSPTNHHLHPYFVSSIPNPQHHPMLDTSQHQETTSTDPNQFDYSHLSMPQSTPLLMKYDITTYVRLIETEKYYMLLDLANELDIWKKIIPSLCLQISENDSFLLDCLMSCSRNTSVNLLDLTNEQLNKWSQLKNAPVISERIQQFEHILISIVLILLGLYLNTTKVRLTDYHKVIFNNQAKLFSHVLRKIHTFITSNKPNSAVLTNAIQSITMLKFFIDKNYDFSYEFKNIQKGRVTDTSEEITYSNSNLYSNPDISYISTFNEYEIIYLNNSYQNLVHVDQSNSMSMGESQLYKDLLWYLMKVDFVINYPEAANNLVLDHNVVYQQITNASTDLSFSNNLNYLNPRSYANYFLKEFIIKVLSMGSNAIIEDANNRINTLFNFIDQSYMDPELKSQFHHCFTWTVRYIHPVSD", "function": "Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.", "AFDB_id": "AF-Q5A4F3-F1-model_v4" }, { "swissprot_id": "C0SP90", "sequence": "MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKDDHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAFFVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNGKITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRKALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDPNEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLILYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLKTSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES", "function": "May have a role in sporulation. Can compensate for the loss of cytochrome aa3.", "AFDB_id": "AF-C0SP90-F1-model_v4" }, { "swissprot_id": "Q06SD7", "sequence": "MTELEKIGLIPRSIVRMLDRFYYQIYLGTAEPLVKQFRFSKYLLLTSVKSLFVVLFIPFFINIFTKIYVFRPLVEYFWDRKQTEIFLNYELQEKAFSEIRNFEEKMYFDYLIKTENFFPEKPKYFLPEAPLPGELPMQKKELFGVNLQEYKFKSNHSCLKFYSTEANSSVFGFENGNSLKLSHVSLFASKYPIKFTVIKNDLFKIKNQEGKSGAFPASEEEKKLKKGEKALLFPLLPTFSFSPRKNSSFFLGEKENMGISPGSKEEKKLKFFFFPHSGGTFSHCSLGIEDSEGKFSPGRREISPLLPGEHCGKLGKNAIFLLEEEKNGSGETRASFATSGSKAPALEELKNQSIDFLIPLEKSSPQRTFFSQHLASDFCSFDLTAQTKFHFVSFPNSIDTVPYNFNKNTESIFRQKTRELANHYNNESISAITNLLADFMGLFILLFLLVNMKMSLMNTTAFLSESFFSLKDSKKAFLMLLFTDLLVGFHSPRGWEVIFHFLFEHFGLPENHNIIFLLVGTFPVLLDALFKYWIFRHLNRHSPATVATFQAMVE", "function": "May be involved in proton extrusion. Indirectly promotes efficient inorganic carbon uptake into chloroplasts.", "AFDB_id": "AF-Q06SD7-F1-model_v4" }, { "swissprot_id": "Q6FTW5", "sequence": "MVTRRRLHHPEVEQVSKRQKVDKAESKNKKHADVAAERGEQSTEDHEDESQDKKDKKVVGDNRDEDEEVSPNGQEAAEDNDDRKDKDAKEKDTETNDEGTEKSHTDVNDDDDDVDESKEEDAAAAVDITKEKKDEQESDNKTEEKKVQENEEEEEEDENKNDEDVEELGSTEPVDDEKKGLVKFEFDGVEYKFKERASVIEENEGKIEFRVVSNDNTRENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYKPFNKRQFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSDIRYFLTYADNYAIGYFKKQGFTKDITLDKKVWMGYIKDYEGGTLMQCSMLPRIRYLDAAKILLLQEAALRRKIRTISKSHVVHPGLECFNDIENIKPIDPMSIPGLKEAGWTPEMDELAQRPKRGPHYAAIQNILVELQNHAAAWPFLRPVNKEEVPDYYEFIKEPMDLSTMELKLENNKYEKMEEFIYDARLVCNNCRLYNGENTSYYKYANRLEKFFNNKVKEIPEYSHLID", "function": "Histone acetyltransferase that acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation. In addition to histone acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and is able to mediate histone crotonylation.", "AFDB_id": "AF-Q6FTW5-F1-model_v4" }, { "swissprot_id": "P0A625", "sequence": "MHPPTDLPRWVYLPAIAGIVFVAMPLVAIAIRVDWPRFWALITTPSSQTALLLSVKTAAASTVLCVLLGVPMALVLARSRGRLVRSLRPLILLPLVLPPVVGGIALLYAFGRLGLIGRYLEAAGISIAFSTAAVVLAQTFVSLPYLVISLEGAARTAGADYEVVAATLGARPGTVWWRVTLPLLLPGVVSGSVLAFARSLGEFGATLTFAGSRQGVTRTLPLEIYLQRVTDPDAAVALSLLLVVVAALVVLGVGARTPIGTDTR", "function": "Part of the binding-protein-dependent transport system ModABCD for molybdenum; probably responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-P0A625-F1-model_v4" }, { "swissprot_id": "P27170", "sequence": "MAKLTALTLLGLGLALFDGQKSSFQTRFNVHREVTPVELPNCNLVKGIDNGSEDLEILPNGLAFISAGLKYPGIMSFDPDKPGKILLMDLNEKDPVVLELSITGSTFDLSSFNPHGISTFTDEDNIVYLMVVNHPDSKSTVELFKFQEKEKSLLHLKTIRHKLLPSVNDIVAVGPEHFYATNDHYFIDPYLKSWEMHLGLAWSFVTYYSPNDVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPVTGDLWVGCHPNGMRIFYYDPKNPPASEVLRIQDILSKEPKVTVAYAENGTVLQGSTVAAVYKGKMLVGTVFHKALYCELSQAN", "function": "Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.", "AFDB_id": "AF-P27170-F1-model_v4" }, { "swissprot_id": "Q02398", "sequence": "MEPTFDIPDSTDWLDTPLTLLAPFETSLRCQVCKDFFDNPVITSCSHTFCSLCIRRCLSTEGKCPTCRSSDQELKLRRNWVVQELVEGFKNARPSILQLARMAQTGTDDSGDLAAEEPASKKRKIEPNAIVGTDGLPEEGIRTRSQSRGASRQPQATPVQVIDDGNDEDYMPDGLVPCPVCGRRMKEEAVFRHLDSCTGTAEELKPAAFGSLAPGPRKSFLAATGKPPERLPVINYSLLKDTVLRKKLKDLGIPNWGPRALLQRRHTEWLNLWNANCDSRTPKPKRELLRELDVWERTQGGNSVTPTDPTNAVMNKDFNTEEWSANYDTDFKALIANARKKNDAVIRSTIPNASQANSDTPRSAQLVDQPIEASLTPQDVDEKSTMNPQDAIDNRTEVPPVPDPPQALSGIDRAVNSPMKNVTEGDAQAIPISSSASTHKTPH", "function": "E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.", "AFDB_id": "AF-Q02398-F1-model_v4" }, { "swissprot_id": "G7J032", "sequence": "MIKEFNTQTTLNVGLEALWAAQSKDITLVVPKVLPNIVKDVQVIEGDGGVGTKLIFNFLPGIAPVNYQREVITEYDELSHTIGLQVVEGGYLNQGLSYYKTTFQFSAISENKTLVNVKISYDHESELIEEKVKPTKTSESTLFYLGQLEKFLLNGA", "function": "Binds gibberellin A3 (GA3) in vitro.", "AFDB_id": "AF-G7J032-F1-model_v4" }, { "swissprot_id": "P48326", "sequence": "MTFDYTNSFYNYDQYNNKKFDIVVLKPLKEEEIEYYLMQSLDALRINKAVVFNFEHIDYPLAQRILDSLAGATYALGGDKTCIREKLYFFVPKTVKLQAPNNETPSFF", "function": "May act as a cell division protein.", "AFDB_id": "AF-P48326-F1-model_v4" }, { "swissprot_id": "Q9LK09", "sequence": "MSARHGQSSYRDRSDEFFKIVETLRRSIAPAPAANNVPYGNNRNDGARREDLINKSEFNKRASHIGLAINQTSQKLSKLAKLAKRTSVFDDPTQEIQELTVVIKQEISALNSALVDLQLFRSSQNDEGNNSRDRDKSTHSATVVDDLKYRLMDTTKEFKDVLTMRTENMKVHESRRQLFSSNASKESTNPFVRQRPLAAKAAASESVPLPWANGSSSSSSQLVPWKPGEGESSPLLQQSQQQQQQQQQQMVPLQDTYMQGRAEALHTVESTIHELSSIFTQLATMVSQQGEIAIRIDQNMEDTLANVEGAQSQLARYLNSISSNRWLMMKIFFVLIAFLMIFLFFVA", "function": "Vesicle trafficking protein that functions in the secretory pathway.", "AFDB_id": "AF-Q9LK09-F1-model_v4" }, { "swissprot_id": "P08709", "sequence": "MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP", "function": "Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.", "AFDB_id": "AF-P08709-F1-model_v4" }, { "swissprot_id": "P60324", "sequence": "MGTFNLWTDYLGLARLVGALHKEEELDVRLDPKPEPKPSSESQQASKESSAAPERLCSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHAHTRRFCPLTSQGYTSVYCYTTRNSAGKKLTRPDKAKTQDAGHRLGGEAAAGVYAGSKSGRKPPGPSPSACCPSTTA", "function": "Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.", "AFDB_id": "AF-P60324-F1-model_v4" }, { "swissprot_id": "P29749", "sequence": "MLFPPSLPPTASGRSLGRVETPPGLVRFMVGLAEAPKGGRVLEPACADGPFLRAFREAHGTGYRFVGVEIDPHALDLPPWAEGVVADFLLWEPGEAFDLILGNPPYGIVGEASKYPIHVLREVKGLYKKTLSTWKGKYNLYGAFIEKSVRLLREGGTLVFVVPATWLVLDDFSLLRSFLAREGRTEVYYLGEVFPGRKVSAVVLRFRKGGKGLALWDTRRDGETFTPLLWSEKPEWKGEIIRFETGWTREMEASGPPLGSLFHIRFAARSPEFKKHPAVQKEPEPGLVPVLTGRNLKPGWIDYESNHSGLWMPKERAKELRDFYATPHLVVAHTKGTKVVAAWDEKAYPWREEFHLLPKEGVELDPLFLVEWLNSDKIQEYVKTLYRDFVPHLTLRMLERIPALLPRKGNTERRKHGPYTSPESAGSF", "function": "A gamma subtype methylase, recognizes the double-stranded sequence 5'-TCGA-3', methylates A-4 on both strands and protects the DNA from cleavage by the TthHB8I endonuclease.", "AFDB_id": "AF-P29749-F1-model_v4" }, { "swissprot_id": "T2KMH0", "sequence": "MKKLWLMGLLLASFFTTVAQNNAQTKSNSDEEIDKKVATLISQMTLDEKIAEMTQDAPANERLGIPSMKYGEALHGLWLVLDYYGNTTVYPQAVAAASTWEPELIKKMASQTAREARALGVTHCYSPNLDVYAGDARYGRVEESYGEDPYLVSRMGVAFIEGLQGTGEEQFDENHVIATAKHFVGYPENRRGINGGFSDMSERRLREVYLPPFEAAVKEAGVGSVMPGHQDFNGVPCHMNTWLLKDILRDELGFDGFIVSDNNDVGRLETMHFIAENRTEAAILGLKAGVDMDLVIGKNVELATYHTNILKDTILKNPALMKYIDQATSRILTAKYKLGLFDAKPKKIDTETVETGTDEHREFALELAEKSIIMLKNDNNLLPLDVSKIKSLAVIGPNAHEERPKKGTYKLLGGYSGLPPYYVSVLDGLKKKVGEHVKINYAKGCDIDSFSKEGFPEAISAAKNSDAVVLVVGSSHKTCGEGGDRADLDLYGVQKELVEAIHKTGKPVIVVLINGRPLSINYIAENIPSILETWYGGMRAGDAVANVIFGDVNPGGKLTMSFPRDVGQVPVTYLERPDFIGSGKGQYRFSDKTPLFPFGFGLSYTTFKYGTPKLDNTSIAANGTTTVSVEVTNTGKVTGDEVVQMYVRDDYASVGRYLKMLKGFKRITLKPGETKTVSFKLGFDELNILNQDLKKVVEPGTFTISVGASSKADDLKTVSLTVK", "function": "Xylosidase involved in ulvan degradation (Ref.2, PubMed:31285597). Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall. It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable). Beta-xylosidase converts Xyl-Rha3S, a product of alpha-L-rhamnosidase acting on Rha-Xyl-Rha3S oligosaccharides, further to Xyl and Rha3S. The enzyme is able to degrade 4-methylumbelliferyl-beta-D-xylopyranoside (MUX) in vitro (Ref.2).", "AFDB_id": "AF-T2KMH0-F1-model_v4" }, { "swissprot_id": "Q9P4X2", "sequence": "MYFLILFSSNAELGEVLRTMRSVEDRFNKRFHYPWTFYGMDEFTEYFMSTTSTIASGHCEYGTKGITYTNHLQFILTISYLVHWDLSQVKPLVENNRLYQQRADALAQENLSYVYSPLFHSFQDWVVRSLLYHPQLEYDYVWRIEPGLKLVCEEKKDIFSTFKDSDIVFTNHVCERKHSGIYAMEEAIEEYKILNTQGDFSNIWVYSNNYTYCKYWPFNEILSLKQIRHNQTYTNLINYLLGSGGTYYHRWTESDILSAAFGVLRARANHMESVGFFLNDDVHYCPETIPYTGRCACL", "function": "Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins.", "AFDB_id": "AF-Q9P4X2-F1-model_v4" }, { "swissprot_id": "A0A095C325", "sequence": "MSASPSPIGAAAGLDHLQARRDEEVVDSEKDALAHDSHAVNSGIPHPTATAPTIGIPIVPISAGRESSAPEEKISRSSIAASSDILHNPPSEKSISSAVPKSHRYKKSKFNFLKSRKKKEEEEKKNKEKEKEASVLPPVSFFALFKFAAPLEIVAMVFGLLLAIAAGSCQPLMTLIFGRLTTSFTNYAVIVNQISQGGLTPETAAALQAAKDDLKTQSGHNALYLMAIGIGMFLATWLYMFIWNVTGELNSKRIRERYLAAVLRQEIAYFDDLGAGEVATRIQTDCHLVQEGTSEKVALVFQYAGTFVCGFVLAFVRSPRLAGALISILPVIMICGGIMMTAMAKFGTAALDHIAKAGSLAEEVIGSIRTVQAFGKEKILGNKFADHIEKSKVIGRKGSIFEGFGLSIMFFAIYAAYALAFYYGGILVSHGDANSGIVINVFMSILIGSFSMAMLAPELAAVTKARGAAAKLFATIDRVPAIDSANKEGLKPDSLHGEISFENVRFHYPSRPSVPILKGFTTTFEAGKTFALVGASGSGKSTVVSLIERFYDPVSGVVKLDGRDIRSLNLNWLRQQIGLVSQEPTLFGTTVRGNVEHGLIGSIYENASPEEKFELVKKACIDANAHGFIMKLPQGYDTMVGERGMLLSGGQKQRVAIARAIVSDPRILLLDEATSALDTQSEGIVQDALDKASRGRTTITIAHRLSTIRDADRIYVMGAGEVIEQGSHNELLNNENGPYAQLVNNQKLAQEAAAEALQEDDDIDDLDDTVLGGASSPMQEKNGQLYRAVTGRSLASIAMDDIQAKRAEDLAAEDKIPSSFALYARLLRMNSADKLIYIFAFIAAICAGMVYPSLAILFGKALSDFEIQDPNELRQALSRKALWYFITALAAAIVIFFQSAGFSRAGWDLNGVLRKKLFTATLRHDIEWFDEDRNSTGAVTSNLADQPQKVQGLFGPTLGTVVQSCATLIGGCIIGLCYGPLLSLIGIACIPILVSGGYIRLKVVVLKDQRMKKLHAASAHLASEAAGAVRTVASLTREEDVRRIYSEALKGPMKLNFRTSIKSQCLFAASQGLTFCIIALVFYIGALWIIDGKYSTASFYTVLNSIVFASIQAGNVFTFVPDASKANSSAASIFRTIDNEPAINAESTEGKMLDHEHVVGHVRIEGVHFRYPTRPGVRVLRNLTIDVPAGTYVALVGPSGCGKSTTIQMLERFYDPLAGRVTLDGIDIKELNLANYRSQISLVSQEPTLYAGTIRFNILLGANKPMEEVTQDEIDAACKDANIYDFIISLPDGFDTEVGGKGSQLSGGQKQRIAIARALIRNPKVLLLDEATSALDSQSEKVVQEALDKAAKGRTTIAIAHRLSSIQHSDQIYYFSEGKVAEHGTHQELLAKKGGYYDLVQMQNLSRQ", "function": "Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as fluconazole (FLC), itraconazole (ITC), posaconazole (POS), nocodazole and voriconazole (VRC).", "AFDB_id": "AF-A0A095C325-F1-model_v4" }, { "swissprot_id": "Q67SL5", "sequence": "MRQDGRLPHEMRPVRITRHYNIHAEGSVLIEVGRTRVICTATLEDRVPPFLRGRGEGWITAEYGMLPRATGQRTAREAARGRQGGRTMEIQRLIGRALRSVIDLAALGERTLIIDCDVIQADGGTRTASITGAYVAMVDALAGLRAAGLIDRLPVKDYLAATSVGVVGGVPVLDLTYEEDSRAAVDLNLVMTGSGEVVEIQGTGEERPFTRRELEELLALAESGVRRLVALQREQLGPLGVEVGAVVTEASGIGHQEPGEGAGVSLAPGGGGL", "function": "Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.", "AFDB_id": "AF-Q67SL5-F1-model_v4" }, { "swissprot_id": "P09852", "sequence": "MTATDRTPPPLKWLCLGNRDANDGFELFAHGIYARNGALVGSKLSLRERRQRVDLSAFLSGAPPLLAEAAVKHLLARLLCVHRHNTDLELLGKNFIPLHASSLGNAGVCERILASARQLQQHQVELCLLLAIDEQEPASAEYLTSLARLRDSGVRIALHPQRIDTDARQCFAEVDAGLCDYLGLDARLLAPGPLTRNLRQRKSIEYLNRLLVAQDIQMLCLNVDNEELHQQANALPFAFRHGRHYSEPFQAWPFSSPAC", "function": "Positive regulation of toxA gene transcription.", "AFDB_id": "AF-P09852-F1-model_v4" }, { "swissprot_id": "P0DO98", "sequence": "MLSLVMKILRKPKIEDIVCNIQNNEEDKEAFIVQYQPFIRKSISSVCRRYITEQDDEYSIGLFAFNEAIEQYSYKKGKSFLAFADLLIKRDVIDYIRKESKHNLVFLKEDEQEEMLEMQVSLTEYMKEIENGNRKEEILHFQSVLADFKITFSELAKESPKHRDTREHLIEIVKVIIKEEEMMEELFRKKKLPLKHIEPRVRVSRKTLERHRKYIIAMCIIFANNYTYILDYIRGGKHDE", "function": "Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor contributes to both stress response and virulence gene expression.", "AFDB_id": "AF-P0DO98-F1-model_v4" }, { "swissprot_id": "P75736", "sequence": "MKLNIRAQTAQNQHNNSPIVLVHGLFGSLDNLGVLARDLVNDHNIIQVDMRNHGLSPRDPVMNYPAMAQDLVDTLDAQQIDKATFIGHSMGGKAVMALTALASDRIDKLVAIDIAPVDYHVRRHDEIFAAINAVSESDAQTRQQAAAIMRQHLNEEGVIQFLLKSFVDGEWRFNVPVLWDQYPHIVGWEKIPAWDHPALFIPGGNSPYVSEQYRDDLLAQFPQARAHVIAGAGHWVHAEKPDAVLRAIRRYLND", "function": "Displays esterase activity toward palmitoyl-CoA, malonyl-CoA and pNP-butyrate.", "AFDB_id": "AF-P75736-F1-model_v4" }, { "swissprot_id": "P15011", "sequence": "MTDRDTPPSLEDISRRLTEAKGGADGAEADGAGSSGPARASGLGIGMRISIELVTTIAVGGAIGYGLDSWLGTSPLAMVVFLVLGGAAGVMNAYRVVKGLDDSVGLGRAIERKEKAEGNKDRA", "function": "A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.", "AFDB_id": "AF-P15011-F1-model_v4" }, { "swissprot_id": "Q20A00", "sequence": "MVYTPALVLGHGIPIVSEEDNIVELMRKFLCQITSSDNKYVRRGSIESSEFIKEINSSLDSETAPDCEERILHQDMTRQIVRCLSEAKESSLRCRILLLPRTLTANVALDVVRSSAGEPCGLRGAFIQVYLETQLGQQLQMLGTITPDPTVTPTFELSVVFKLDKDCWPLLKHIFVTDKVLKLRPQYRLVKKKLYSSASPVIHEFC", "function": "Inhibits cell growth by regulating the TOR signaling pathway upstream of the tsc1-tsc2 complex and downstream of akt1.", "AFDB_id": "AF-Q20A00-F1-model_v4" }, { "swissprot_id": "P76077", "sequence": "MTQEERFEQRIAQETAIEPQDWMPDAYRKTLIRQIGQHAHSEIVGMLPEGNWITRAPTLRRKAILLAKVQDEAGHGLYLYSAAETLGCAREDIYQKMLDGRMKYSSIFNYPTLSWADIGVIGWLVDGAAIVNQVALCRTSYGPYARAMVKICKEESFHQRQGFEACMALAQGSEAQKQMLQDAINRFWWPALMMFGPNDDNSPNSARSLTWKIKRFTNDELRQRFVDNTVPQVEMLGMTVPDPDLHFDTESGHYRFGEIDWQEFNEVINGRGICNQERLDAKRKAWEEGTWVREAALAHAQKQHARKVA", "function": "Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit A is the catalytic subunit involved in the incorporation of one atom of molecular oxygen into phenylacetyl-CoA.", "AFDB_id": "AF-P76077-F1-model_v4" }, { "swissprot_id": "Q9Y8T3", "sequence": "MAIARPGFSVYLTIAWPSPDTFLEIASTLKGCVDYLELGIPTPKPLYDGPTIRLTHLKAVESGYSGPKTLSLAEEASQEAGVPYIVMAYATEQPWSFSEVLREASRKGALSVLPPDLPFELPGHVEWYVEESRRLGMEPSLFASPKFPHRWLDRYRRLDPLLIYLGLQPATGVKLPLAFLRNVKTARKIVGQVYMLAGFSIKSPEDALRVLEAGADAVVVGSEVARLVSSGRLGEARHLACSIRAAISERGG", "function": "The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.", "AFDB_id": "AF-Q9Y8T3-F1-model_v4" }, { "swissprot_id": "Q9VCR6", "sequence": "MNYLTILLCNRKPTMLSRRNKEKSQHKEGVVGKYMKKDTPPDISVINVWSDQRAKKKSLQRCASTSPSCEFHPRSSSTSRNTYSCTDSQPDYYHARRAQSQMPLQQHSHSHPHSLPHPSHPHVRSHPPLPPHQFRASSNQLSQNSSNYVNFEQIERMRRQQSSPLLQTTSSPAPGAGGFQRSYSTTQRQHHPHLGGDSYDADQGLLSASYANMLQLPQRPHSPAHYAVPPQQQQHPQIHQQHASTPFGSTLRFDRAAMSIRERQPRYQPTSSPMQQQQQQQQQQQQQLQHTQLAAHLGGSYSSDSYPIYENPSRVISMRATQSQRSESPIYSNTTASSATLAVVPQHHHQGHLAVPSGSGGGSLSGSGRGGSSGSVRGASTSVQSLYVPPRTPPSAVAGAGGSANGSLQKVPSQQSLTEPEELPLPPGWATQYTLHGRKYYIDHNAHTTHWNHPLEREGLPVGWRRVVSKMHGTYYENQYTGQSQRQHPCLTSYYVYTTSAEPPKAIRPEASLYAPPTHTHNALVPANPYLLEEIPKWLAVYSEADSSKDHLLQFNMFSLPELEGFDSMLVRLFKQELGTIVGFYERYRRALILEKNRRAGQNQNQNQ", "function": "Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Required for cell cycle exit in eye imaginal disk and hid-induced apoptotic cell deaths that are part of normal retinal development. Activation of Drice in eye imaginal disk by either Hid or Rpr is almost completely blocked by Sav expression.", "AFDB_id": "AF-Q9VCR6-F1-model_v4" }, { "swissprot_id": "Q7VJ92", "sequence": "MQADLSNIIALYGGSFDPLHYAHMEIIRLLRENLLYKRIILMPNYRNPLKSSSFFTPLQRLQMCKILADEMNNAKSCNQKIPYISVSDYEVCQNRSVFSVQSVAFIKEQITKQDTNAQLVFVLGEDSFNNLKQWKDVEKLCKMVDFVLIKREISQKDSQISPHIVPYAHVIKCLDLPPSVAHFSSSSVRSLLQKGQIDEALNLVPVCLHTFIKANFRL", "function": "Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).", "AFDB_id": "AF-Q7VJ92-F1-model_v4" }, { "swissprot_id": "A5G9G5", "sequence": "MKTLWAEISCEVPVAMVDLLSDFLVELSGNGVSIENLALDTFSLETVEDSPVKTVKAYFNGDSPLGSQLDAIETFLHAHGSAFAGFVFKHPVVATIKEEDWANNWKEYFKPVRIGSRLVIKPTWEEYAAGEGDIVLKLDPGMAFGTGAHPTTKMCLEVLEMIFYGEGPYNGDGKHLDPVTVLDVGTGSGVLSIAAAKLGAERITAIDIDADAVSVAEENLALNDALPLVAVSTTALQDVPGRYDIVLANILAEELVRLAPELVDRTAPGGYLVLSGILTEKEEFVINGFGGFGLSLIERRREAEWSCLGFRLESK", "function": "Methylates ribosomal protein L11.", "AFDB_id": "AF-A5G9G5-F1-model_v4" }, { "swissprot_id": "O95886", "sequence": "MRGYHGDRGSHPRPARFADQQHMDVGPAARAPYLLGSREAFSTEPRFCAPRAGLGHISPEGPLSLSEGPSVGPEGGPAGAGVGGGSSTFPRMYPGQGPFDTCEDCVGHPQGKGAPRLPPTLLDQFEKQLPVQQDGFHTLPYQRGPAGAGPGPAPGTGTAPEPRSESPSRIRHLVHSVQKLFAKSHSLEAPGKRDYNGPKAEGRGGSGGDSYPGPGSGGPHTSHHHHHHHHHHHHQSRHGKRSKSKDRKGDGRHQAKSTGWWSSDDNLDSDSGFLAGGRPPGEPGGPFCLEGPDGSYRDLSFKGRSGGSEGRCLACTGMSMSLDGQSVKRSAWHTMMVSQGRDGYPGAGPGKGLLGPETKAKARTYHYLQVPQDDWGGYPTGGKDGEIPCRRMRSGSYIKAMGDEESGDSDGSPKTSPKAVARRFTTRRSSSVDQARINCCVPPRIHPRSSIPGYSRSLTTGQLSDELNQQLEAVCGSVFGELESQAVDALDLPGCFRMRSHSYLRAIQAGCSQDDDCLPLLATPAAVSGRPGSSFNFRKAPPPIPPGSQAPPRISITAQSSTDSAHESFTAAEGPARRCSSADGLDGPAMGARTLELAPVPPRASPKPPTLIIKTIPGREELRSLARQRKWRPSIGVQVETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQADLELEGLAGLATVATEDKALQFGRSFQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSPGPAPAPTPGPGAGRRDSWIERGSRSLPDSGRASPCPRDGEWFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSMDPTAFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKLLEPKEEKKVPPPIPKKPLRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQTRL", "function": "May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.", "AFDB_id": "AF-O95886-F1-model_v4" }, { "swissprot_id": "A0A161CFW5", "sequence": "MSGKLRLYKEKLEGYNRFYSIVKTIKMVTLAKYRAAQGRIRTRDFSLRYTELAFSKPQASRDAVAAAKNALVYIPITTNRGSCGALNSNIVRCIDSVVSSKMVLMPVGKRGIDSFSKLYPDEFRYGIINDMKESMHFGYATFVIENAYEVSKDADRYQVIFNRFVSAGVQRNAVYNIPSYEKWKEDLADAASSDNQKNRYLFANALQNEEEQLIRDFFDFHAALAVLNAVGENELSEQAARLVAVEGQLTNISSLQQRTSSLYNKTRQFGITAALIEILSAMSSLEGNAMKGVRRNKFWEGAVTK", "function": "Mitochondrial membrane ATP synthase (F(1)F(o) ATP synthase) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(o) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Contrary to the procyclic, insect form that requires F(1)F(o) ATP synthase for ATP synthesis, the bloodstream form relies on ATP hydrolysis by F(1)F(o) ATP synthase to maintain its mitochondrial membrane potential.", "AFDB_id": "AF-A0A161CFW5-F1-model_v4" }, { "swissprot_id": "Q9I6V6", "sequence": "MGLFNAHAVAQQRADRIATLLQSFADGQLDTAVGEAPAPGYERLYDSLRALQRQLREQRAELQQVESLEAGLAEMSRQHEAGWIDQTIPAERLEGRAARIAKGVNELVAAHIAVKMKVVSVVTAYGQGNFEPLMDRLPGKKAQITEAIDGVRERLRGAAEATSAQLATAAYNARIKSALDNVSANVMIADNDLNIIYMNRTVSEMLGRAEADIRKQLPNFDAGRLMGANIDVFHKNPAHQRHLLANLTGVHKAELNLGGRRFSLDVVPVFNDANERLGSAVQWTDRTEEHRAEQEVSQLVQAAAAGDFSKRVEEAGKEGFFLRLAKDLNSLVDTADRGLRDVSRMLGALAQGDLTQRIEADYQGTFGQLKDFSNDTAQSLSRMLGQIREAADTINTAASEIASGNAELSARTEQQASSLEETASSMEELTSTVKLNAENARQANSLAANASEVATQGGTVVQKVVSTMSSINESARKIADIIGVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLAQRSAAAAKEIKTLISDSVDKVENGNTLVAQAGQTMSDIVVAIRRVTDIMSEIAAASAEQSTGIEEVNSAVSQMDDMTQQNAALVEEAAAAAEAMQEQAGLLNQSVAVFRLDTPPSVVQLASARPSAPRPSAPAPLARSGMARASKARKEDGWEEF", "function": "Chemoreceptor that plays a critical role in the virulence and pathogenesis of P.aeruginosa in a variety of hosts. Probably acts through oxygen sensing. Uses a heme-based sensor. Could be involved in chemotaxis. When expressed in E.coli, is able to sense and mediate repellent responses to oxygen, carbon monoxide and nitric oxide.", "AFDB_id": "AF-Q9I6V6-F1-model_v4" }, { "swissprot_id": "P94438", "sequence": "MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAANHVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSVLCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQFQELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLLREWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKNAGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLVIKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGPVQQKESLS", "function": "Required for resistance to linearmycins, a family of antibiotic-specialized metabolites produced by some streptomycetes. Member of the two-component regulatory system LnrJ/LnrK, which induces expression of the LnrLMN ABC transporter in response to linearmycins and other polyenes. Acts as a specific sensor for linearmycin, either directly through binding or indirectly through membrane perturbation. Probably activates LnrK by phosphorylation. May also promote biofilm formation.", "AFDB_id": "AF-P94438-F1-model_v4" }, { "swissprot_id": "Q9LV88", "sequence": "MEKLDKRREEETYLWIPVQFLDQALIAVLKCIGLLCQPAKKTAPSPVTFNQPEEQEEDYGVALKDDDVVVLLRDNKAKSKKRDKEKPSSGRPGQTNSVPNAAIQVYKED", "function": "Elicitor of plant defense.", "AFDB_id": "AF-Q9LV88-F1-model_v4" }, { "swissprot_id": "Q54IV3", "sequence": "MSKRVSAFGAEGDDEPQEKPMKPFISFSSNINNNNNSNNNNNNNNNNNNNNNNNNNKNNIGTGINLNIKNNNNINNNNNKSGFPVKKSRFNGEDDDDDYFFSNVPPKSSMTTLNKSPPNFENASSNNNNNNNNNNQESDSKNQNEDEDDEIDPLDAFMENVNAQAAIDNSKSIEKGQQQQQSLKSKRDDIDNEDDEEIFYKLRQKQLANKSSKQQQDDDVDYSSLDDDDGYFDDEESLKNGQSKGKRIIEPLPPIDHSKEEYIEFNKIFYEEHPDIANLTEEQVFEIRKNLDIRMTGTDLINPVTSFGHYGFDDILLQAIAKQSIETPTPIQKQAIPIALSGRDLIAIAKTGSGKTATFIWPSISHIMDQPYLEKGDGPIALFLAPTRELAHQIYLETLKYSKYFKLKTTVLYGGVSKQQQCKELKAGCEIIVATPGRLIDMIKLKATKLNRVSYLVLDEADKMFDFGFGPQVLSIVNHVRPDRQTLLFSATFKPNVEEFARTILSDPIKISIGMIGSANSDITQIVQVLKSDSDKWNWLTNQLALLLSQGSVLIFVSTKVAVEQLSSNLTKFGFQTCTLHGDKNQIERSQTIQTFKEGKINILIATDVAARGLDIPLIKNVVNYDTSRDIESHTHRIGRTGRAGNTGVAYTLITPKDIHFSVDLIKNLESASQFVPPELIDVAMNNPHFKRERGGGGGGSNRGRGRGGGGVGYRRNSRGGGVAFNSNRDSSRSDSQNKFIPAQSVEGGRLFNPNNTDNSEINNENEKSINNENKFSNNNSGSSNDRNSINYRNNSFNNNSNNTNNSGNSNFNNSNSNNGYSNNNYNNNYKNNSNYNNSNNNNNSYYNNNNSNNNNNSNYNNSSNNNNNNNNNYRNGNNNNNYNNNNYYNNNNSNNNSSNNNNSNNNSSNNNFNNNFNNNNNNNDNSNFNRALPFNDFNNNNNNSNNNNFNYNNNFNNSYNANNSNHYKNNNNSNNFNQRSQYNRR", "function": "probable ATP-dependent RNA helicase which may bind to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures.", "AFDB_id": "AF-Q54IV3-F1-model_v4" }, { "swissprot_id": "Q18612", "sequence": "MVKSTTAGNNAVSSLESTDSKKSRKEKSREKEHRRAQCINSAFEILQQHIPYLKSEERKSLPKIKTLRLAMQYIDHLKKLLGGNEMLETDCNESRPLTHSDFRVNISNEIRIRNSYRERAHNQELDEATVKRILAREDQRRRCSSVPEGIQRYTPYQSRQFGPISNNVCNFRHVDANQYNTNFMEYQTQMVQVANFPNQFSHEYYNYGTFPVIDPTSLENSNPILQ", "function": "Probable transcription factor which regulates early embryonic myogenesis, in cooperation with transcription factors unc-120 and hlh-1. Involved in controlling the number and position of somatic gonadal precursor cells (SGPs) in the gonadal primordium, and embryonic body shape.", "AFDB_id": "AF-Q18612-F1-model_v4" }, { "swissprot_id": "Q5GS66", "sequence": "MYVVIINIVLLKVLMVLTITILSGGFSRERKISLMSGKAVKKALDSLSYNAIEIDVNSNTAEKLKKINPDLAFIALHGPYGEDGCIQGLLEILGIKYTHSGVMASAIAMNKAMSKHIFRSLGIDTPKGYIISRGDILKNNIKIDYPYVLKPINEGSSIGVHITFSHEDYLKLKNMFSVIPVHDAGIEEEEPVWITRDLMIIEEYIPGIELHTAVLLDEAAGTMEIRPKNKFYDYKAKYTNGFAEHIFPAEIPDNIYEMTLEHALKVHRFLGCKTISRSDFRYNPKDNTLKMLEINTHPGFTELSLVPEIAKLTKGIDFNELVKIIIEDSLQHKKILEIK", "function": "Cell wall formation.", "AFDB_id": "AF-Q5GS66-F1-model_v4" }, { "swissprot_id": "Q9P5L0", "sequence": "MSAEFTYQDVAEHNTKKDLYVVIHDKVYDITKFVDEHPGGEEVLLDVAGQDSTEAFEDVGHSDEAREALEPLLVGTLKRQAGDPKPKAPLPSSLAPAAQTGTATGLGIGLYAVLVLGGLAGFAAYQYLQAQQGATAPSA", "function": "Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.", "AFDB_id": "AF-Q9P5L0-F1-model_v4" }, { "swissprot_id": "P38331", "sequence": "MTATITNKKSCSGSVEAGKTRLTTEWKPESQVPQYVKNELSKPHPNYILAFLNVVQQLKIQRRTGYLDLGIKECESISDHMYRLSIITMLIKDSRVNRDKCVRIALVHDIAESLVGDITPVDPIGKEEKHRREWETIKYLCNALIKPYNEIAAKEIMDDWLAYENVTSLEARYVKDIDKYEMLVQCFEYEREYKGTKNFDDFFGAVASIKTDEVKGWTSDLVVQRQKYFADLTQSITK", "function": "Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).", "AFDB_id": "AF-P38331-F1-model_v4" }, { "swissprot_id": "P13186", "sequence": "MPNPNTADYLVNPNFRTSKGGSLSPTPEAFNDTRVAAPATLRMMGKQSGPRNDQQQAPLMPPADIKQGKEQAAQRQNDASRPNGAVELRQFHRRSLGDWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGYDFKAPSYVPNRVPLTPEMIDSQVLKEMYRLEFIDDIEDTRRSLIRLVTEKEYIQLSQEYWDKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEPDSNFEDPTLAYHPLLSIYHLVSEMVARKLAKLQRRQALALQAQAQQRQQQQQVALGTKVALNNNSPDIMTKMRSPQKEVVPNPGIFQVPAIGTSGTSNNTNTSNKPPLHVMVPPKLTIPEQAHTSPTSRKSSDIHTELNGVLKSTPVPVSGEYQQRSASPVVGEHQEKNTIGGIFRRISQSGQSQHPTRQQEPLPEREPPTYMSKSNEISIKVPKSHSRTISDYIPSARRYPSYVPNSVDVKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQRQKLLQENLDKLQINDNDNNNVNAVVDGINNDNSDHYLSVPKGRKLHPSARAKSVGHARRESLKFTRPPIPAALPPSDMTNDNGFLGEANKERYNPVSSNFSTVPEDSTTYSNDTNNRLTSVYSQELTEKQILEEASKAPPGSMPSIDYPKSMFLKGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKEVKGGFICVQQRPSIETAAVPVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTASSASRNSSIKRQGSYKRGQNNIPLTPLATNTHQRNSSIPMSPNYGNQSNGTSGELSSMSLDYVQQQDDILTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVKVRIVGLAGVHFKKVSGNTWLYKELASYILKELNL", "function": "Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.", "AFDB_id": "AF-P13186-F1-model_v4" }, { "swissprot_id": "B1GVX4", "sequence": "MSSEKMPIETLQADEHRFAIILGAGAAGIIQGCTFIREKTLPLEEFQILERQSAFGGVWWKNTYPGAACDIPSHEYQISFALNPYWSRTFAPQPEIQKYFEDVALQYELHKSTTFNTEIVEAKWDDSRLLWLVETTDLTTGDTKLWSCHVLIGALGAFTVPKKAPVKNVDAFKGEEWHSVDWPKNANLKGKTVAVIGTGPSACQFIPNIYPEVKSLIVYQRSPGHVLPRNDVVVGSLTKWMFAHIPFLMRFNRWFWMKKDEILRPRLFTVGSWLQKIVISMTRNHLYKQIKDDTLRRKLESKDVFGCKRPLMLSDYYPIFNNDNVELVTDSVTELTENGIKSRNTDTGEEMERETDVLIWGTGYNPVDFGLPVPTKGRSGQLLCDKYQPELFSLYGVAVDDFPNYFNFLGPNSSSFETSVMELFELQAHHNSIATEYLFQKNVGTFRYAIMPKEERVRSWTLSLRPGQAKLPPANPNCKSYYRSKIGHVYRYPYPYWQYKALIAKLDFKRDWVLLQQRIGQKEVKVLEF", "function": "FAD-binding monooxygenase; part of the gene cluster A that mediates the biosynthesis of botcinic acid and its botcinin derivatives, acetate-derived polyketides that contribute to virulence when combined with the sesquiterpene botrydial. Botcinic acid and its derivatives have been shown to induce chlorosis and necrosis during host plant infection, but also have antifungal activities. Two polyketide synthases, BOA6 and BOA9, are involved in the biosynthesis of botcinins. BOA6 mediates the formation of the per-methylated tetraketide core by condensation of four units of malonyl-CoA with one unit of acetyl-CoA, which would be methylated in activated methylene groups to yield a bicyclic acid intermediate that could then either be converted to botrylactone derivatives or lose the starter acetate unit through a retro-Claisen type C-C bond cleavage to yield botcinin derivatives. The second polyketide synthase, BOA9, is probably required for the biosynthesis of the tetraketide side chain of botcinins (Probable). The methyltransferase (MT) domain within BOA6 is probably responsible for the incorporation of four methyl groups (Probable). The trans-enoyl reductase BOA5 might take over the enoyl reductase function of BOA6 that misses an ER domain (Probable). The monooxygenases BOA2, BOA3 and BOA4 might be involved in further hydroxylations at C4, C5 and C8, whereas BOA7, close to BOA9, could potentially be involved in the hydroxylation at C4 in the side chain of botcinins (Probable).", "AFDB_id": "AF-B1GVX4-F1-model_v4" }, { "swissprot_id": "A3LZU7", "sequence": "MTGLLNGKVVAITGGVTGIGRAIAIEMARNGAKVVVNHLPSEEQAQLAKELKEEISDGENNVLTIPGDISLPETGRRIVELAVEKFGEINVFVSNAGVCGFREFLEITPETLFQTVNINLNGAFFAIQAAAQQMVKQGKGGSIIGISSISALVGGAHQTHYTPTKAGILSLMQSTACALGKYGIRCNAILPGTISTALNEEDLKDPEKRKYMEGRIPLGRVGDPKDIAGPAIFLASDMSNYVNGAQLLVDGGLFVNLQ", "function": "NAD-dependent dehydrogenase that has high activity with L-rhamnose and L-lyxose, and shows only low activity with L-mannose. Has no activity with NADP. Catalyzes the first step in an alternative pathway for rhamnose utilization that does not involve phosphorylated intermediates.", "AFDB_id": "AF-A3LZU7-F1-model_v4" }, { "swissprot_id": "Q86W50", "sequence": "MALSKSMHARNRYKDKPPDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSIDIPLERLIPTVPLRLNYIHWVEDLIGHQDSDKSTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKVPQKTLLMDALKEESEIIYDFCMCNPPFFANQLEAKGVNSRNPRRPPPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRIQGVPKVTYTEFCQGRTMRWALAWSFYDDVTVPSPPSKRRKLEKPRKPITFVVLASVMKELSLKASPLRSETAEGIVVVTTWIEKILTDLKVQHKRVPCGKEEVSLFLTAIENSWIHLRRKKRERVRQLREVPRAPEDVIQALEEKKPTPKESGNSQELARGPQERTPCGPALREGEAAAVEGPCPSQESLSQEENPEPTEDERSEEKGGVEVLESCQGSSNGAQDQEASEQFGSPVAERGKRLPGVAGQYLFKCLINVKKEVDDALVEMHWVEGQNRDLMNQLCTYIRNQIFRLVAVN", "function": "RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs. Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA. Specifically binds the 3'-end of the MALAT1 long non-coding RNA.", "AFDB_id": "AF-Q86W50-F1-model_v4" }, { "swissprot_id": "Q568N4", "sequence": "MDPQGQLRNLRDFLLVYNRMTEICFHRCSSNFNYRNLTMDEERCVDSCAGKLIRTNHRLMGTYVQLMPAMVQKRMQEMESKAAEMAKAEAEAAAKAGTSVPDNPSSAITNASMMSPSIQDIPNTSSTAPNGFQILSSPDNTSDIKTSSMTNGSAFGETNLHVITNDAKTFTNQSLDELITPSPVNTSVPETPTAGGAGQTPS", "function": "Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force.", "AFDB_id": "AF-Q568N4-F1-model_v4" }, { "swissprot_id": "Q3SZW3", "sequence": "MGTGGQNGLRPGKGNTEGVKEGKGKTDEVTMTSNTDASASCQYRCIECNQEAKELYRDYNHGVLKITICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNTKINMHGKLCVFCLLCEAYLRWWQLQDSSQSIDPDDFIRYAKEWDFYRMFAIASLEQTAYFIGIFAFLWVERPIRAKEKLNFTLLLKALLLSSYGKLLLIPAVIWEHDYTPLCLRLIKVFVLTSNFQAIRVTLNINRKLAFLAILSGLLVESTMVYFFQRMEWAVGSDCAIYKSQDF", "function": "Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes.", "AFDB_id": "AF-Q3SZW3-F1-model_v4" }, { "swissprot_id": "Q8VBZ0", "sequence": "MSTLRALRAVLCVYAVGIAVALAQLLRRLRGDFRPPVLPPQPGRVAIVTGATAGIGRSTARQLARLGMCVVVAGNDEHRGQEVVSSIRAEMGSDRAHFLPLDLASLASVRGFARDFQALGLPLHLLVNNAGVMLEPRAETEDGFERHLGVNFLGHFLLTLLLLPALRASGAEGRGSRVVTVGSATHYVGTVDMADLHGRHAYSPYAAYAQSKLALALFALQLQRILDARGDPVTSNMADPGVVDTELYRHAGWVLRTAKRFLGWLVFKSPEEGAWTLVYAAAAPELEGVGGRYLRDEAEAEPLGTARDQELQRRLWAEGLRLTGAGGGDSDGVAW", "function": "Involved in the positive regulation of starvation-induced autophagy.", "AFDB_id": "AF-Q8VBZ0-F1-model_v4" }, { "swissprot_id": "P0CJ87", "sequence": "MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGEAPPPQPAPPDASARQGQMQGIPAPSQALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRALLEEL", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-P0CJ87-F1-model_v4" }, { "swissprot_id": "Q20910", "sequence": "MFSAESNLRNRWRLSKTLSENIFLKIDENLKIETQILEERKKKALKLLIIGPGESGKSTIVKQVRILHCGGYSVEEKRALKHGIYINILEGIDEIHWAIMWRQLIYENPSSIECLNQIRIFTKQFNKTGETENVLCKDIIKSIQMYIKDETVAMMLRNKTVYNIEDSTIHFIENLARVIGKEYLPTGEDILKTRVPTLGIAQYEANIKHLTFKFIFFDIGGQRAQRRKITHLSGHVLDDSHAILFITSLSEYNQVLREDAFVSRIEESLHLFNEICNGMYFHSTAIILFLNKIDLFEIKITHTNITVAFPDYEGPRERDCALEYIRVQFISLNNNKNRKIYQHVTSATDTARIQVVIDMLFDIIISASLKMVGV", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.", "AFDB_id": "AF-Q20910-F1-model_v4" }, { "swissprot_id": "P33532", "sequence": "MASKIASLFSPSETASKDQHENVAEDLELGTASSQSDGIHETNSEYDEKKREESPEVIDISNLISSDHPAHPQNWHWAKRWSIVFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVDINAKYGWRWLYYINIIVGGFFLIVILIIPETLPIKVITRYENAKGRIVEGIPKNNLKEVLKKCKFVTTMGFRMMLTEPIILSMGLYNFYAYGISYFFLTAIWPVFYDTYKMSEMGASCTYLSGFVASTLLFLYQPIQDWIFRRDKAKNNGVARPEARFTSALFITLLFPAGMFLFAFTCHPPFPWMSPIVGNSMVTVANGHNWMCILNYLTDSYPLLSGSAVAAFTLPSFIGATVFAHVSQIMFNNMSVKWAVATMAFISISIPFIIYTFYFFGQRIRALSSLTGNKALKYLPLENN", "function": "Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine. Also imports, but does not export, amiloride and so confers sensitivity.", "AFDB_id": "AF-P33532-F1-model_v4" }, { "swissprot_id": "Q59168", "sequence": "MTNPAYFPQLSQLDVSGEMESTYEDIRLTLRVPWVAFGCRVLATFPGYLPLAWRRSAEALITRYAEQAADELRERSLLNIGPLPNLKERLYAAGFDDGEIEKVRRVLYAFNYGNPKYLLLITALSESMQMRPVGGAEVSSELRASIPKGHPKGMDPLLPLVDATKASTEVQGLLKRVADLHYHHGPASDFQALANWPKVLQIVTDEVLAPVARTEQYDAKSRELVTRARELVRGLPGSAGVQRSELMSMLTPNELAGLTGVLFMYQRFIADITISIIHITECLDGAEAASKSPFPI", "function": "Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. Acts on 2-haloalkanoic acids whose carbon chain lengths are five or less.", "AFDB_id": "AF-Q59168-F1-model_v4" }, { "swissprot_id": "Q8KLK5", "sequence": "MGVDLQVTVNLDHPELLDAPVLETGVLSAEGRALPTPPRPRIVGVGTAVTRTSYSQQEVLDAFGITDRKVRSIFLNSAIERRNLTLPPMDSDSVRVSESQGDLLDKHKKLAIEMGAEALHACLKRCGAELSDLRHLCCVTSTGFLTPGLSALLIRELGIDRHCSRSDIVGMGCNAGLNALNVVAGWSAAHPGELAVVLCAEACSAAYTMDSTMRTAVVNSLFGDGAAAVALLAGPGGATPATSEGPTVLKFASCIIPEAVDAMRYDWDRTQGRFSFFLDPQIPYVVGAHAETVVDRLLSGTGLRRSDIGHWLVHSGGKKVIDAVVVNLGLTRHDVRHTIGVLRDQGNVSSGSFLFSYERLLEEGITRPGEYGVLMTMGPGSTIETALVQW", "function": "Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the Claisen condensation of four molecules of malonyl-CoA to yield 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) and three free coenzyme A (CoA). DpgA requires the presence of the dehydratases DpgB and DpgD to facilitate the aromatization of the DPA-S-DgpA or DPA-S-CoA intermediate.", "AFDB_id": "AF-Q8KLK5-F1-model_v4" }, { "swissprot_id": "P64942", "sequence": "MATSKVERLVNLVIALLSTRGYITAEKIRSSVAGYSDSPSVEAFSRMFERDKNELRDLGIPLEVGRVSALEPTEGYRINRDAYALSPVELTPDEAAAVAVATQLWESPELITATQGALLKLRAAGVDVDPLDTGAPVAIASAAAVSGLRGSEDVLGILLSAIDSGQVVQFSHRSSRAEPYTVRTVEPWGVVTEKGRWYLVGHDRDRDATRVFRLSRIGAQVTPIGPAGATTVPAGVDLRSIVAQKVTEVPTGEQATVWVAEGRATALRRAGRSAGPRQLGGRDGEVIELEIRSSDRLAREITGYGADAIVLQPGSLRDDVLARLRAQAGALA", "function": "Does not seem to be involved in pupylation or substrate degradation.", "AFDB_id": "AF-P64942-F1-model_v4" }, { "swissprot_id": "Q6E7H0", "sequence": "MAPSGTVADPPQCSTTDSFNSSDTAENDIRPFFVLHKASSGNHNGKLTGIVKSKRRIESPSPKIAKRSEVESVEEEDGQFFSTLRFKVFETVWSKIEKTIEDVLRNSNSKVFSGIHDWIRESFESIISSGALKLSEAVRSYPVLTQASSKQLLTAMVLTRNLEMVDDLLTFEELELHLKSQGCHVAKLSSMDFSAKSGVGGCLRGLLRQFVMPTVDVADVTILASWYRENKNHENPVVIIVDDTERCCGPVLSDLILILSEWAIKVPIFLIMGVSTAHDAPRKILSVNALQRLCATRFTLSSPAERMDAVLKAVFLKPCSGFTVSHKVALFMRSYFLCQDGTLTSFVRTLKIACLQHFSLEPLSIMLEHFCHDGVNQLSGEGTELLTEATMKHAFDLPSVTRNKITRSTFEMLPHFLLDLQRMPNPWSIVVLCLYEAGKFDKLRLLDIFCEILDPEARYLKYFSPSEIVNSQSHNSGRNNVIRRVLRKLRDLSPSQLSSMLKSWENLTAEFTEINDKVIELHPFMRAVEAAGQRQGLPNSPKKHASRSNSKLEKELKAMTDKVATVIEFMLREYMKPVESVPFHEILCFKNVDKLQSALLGDPRGRIQLDLLESHDILHCVCCSQRGTTLLPSMHDTSILYKLAQEHADVINLHDWYQSFKTILIPRSSKAKQKSKSSSKSKKRKEICEEPEAPAEALIQARFCRAVMELQITGLIRMPSKRRPDFVQRVAFGS", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet.", "AFDB_id": "AF-Q6E7H0-F1-model_v4" }, { "swissprot_id": "P39569", "sequence": "MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYIDGLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQAILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPNLVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDEPFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWIPMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAFIMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASFTVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQPGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR", "function": "Involved in the response to the germinative mixture of L-asparagine, glucose, fructose and potassium ions (AGFK). Cannot stimulate germination in the absence of gerD and gerK gene products (fructose and glucose receptors respectively).", "AFDB_id": "AF-P39569-F1-model_v4" }, { "swissprot_id": "Q4P821", "sequence": "MSFGRPPTFSDFKVSPPERGSFPLDHDGECKSVMQEYMNCIKYNRNDNGKCRHLSRAYLQCRMDKGLMEQDNMDNLGFKDVVDPASTETKNAAAAAAAYRAASQGRGAHSGLAVSYAGDTHGVERHTNSAKAGSGSAADESNRDANARANANGHVSRQDASYAGDSHAQSGTARLV", "function": "Required for the assembly of mitochondrial cytochrome c oxidase.", "AFDB_id": "AF-Q4P821-F1-model_v4" }, { "swissprot_id": "P12040", "sequence": "MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVIERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYGGKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEHDTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA", "function": "Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.", "AFDB_id": "AF-P12040-F1-model_v4" }, { "swissprot_id": "Q12462", "sequence": "MVCDTLVYHPSVTRFVKFLDGSAGREKVLRLLQYLARFLAVQNSSLLARQLQAQFTTVRKFLRFLKPLNHLQAAAKFYDNKLASDNVVRVCNVLKNIFFAAYLSLDQVNLLRILKVIPVTVLTGKKIPRWSNWCWLFGLLSGLAMDLRKIQTSHAQIAAFVKAKSQSQGDEHEDHKKVLGKAYQDRYTALRRLFWDAADSFIVLNNLGYLSSNEEYVALSGVVTSILGMQDMWKAT", "function": "Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis.", "AFDB_id": "AF-Q12462-F1-model_v4" }, { "swissprot_id": "P42410", "sequence": "MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGANGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEIETALDLEQGLETLKRELGE", "function": "Negative regulator of sigma-B activity. Non-phosphorylated RsbS binds to RsbT, preventing its association with RsbU. Requires any one of RsbRA, RsbRB, RsbRC or RsbRD to sequester RsbT. When RsbS and the RsbR paralog(s) are phosphorylated, they release RsbT, which can then bind and activate RsbU.", "AFDB_id": "AF-P42410-F1-model_v4" }, { "swissprot_id": "Q9N4U2", "sequence": "MRNAGGDKPFSTPVLLREMGLKTHVDDDPKTKAYRLIGYAAVTFSTVSVICFCVTMPVVFTYVQSVKRQMSHEMATCNVNARQIFDDVAALRAGFPFAQAGNRTARQAGYDVHPSKPTPVGYSGGDAAAAEVKGNSPAAAYEDKPFVAVGVEEGPHTATTGSDSEGTCHDCCLPGPPGPPGPPGRPGPNGKAGANGLNGNPGRPPEAPCEPVTPPPCPPCPAGPKGAPGQAGYPGADGQPGSQGDNGEKGSDGAAGEKGRPGPLGKIGEPGATGETGENAENSEPTPGPQGPPGAIGPVGSRGTPGHPGEDGEAGAPGAPGENGTDGENGEDGVPGVPGHDGKAGRAGERGICPKYCAKDGGIFFEDGTRR", "function": "Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway, perhaps in the formation of the adult cuticle.", "AFDB_id": "AF-Q9N4U2-F1-model_v4" }, { "swissprot_id": "Q3UX43", "sequence": "MTGEKIRSLRRDHKPSKEDGDVLEPCEEEATAALGGAFTGGRSGPGGSGKGGKACHKIFSHHHRLQLKAPAVPGPGVPAPPQHNAVTATCPAPACLGGSNPALVADGGGCPSLYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVGEKRPRLLKALKELGDFYLELHWDFQSWVPLLSRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFVVLDNEQKVYQRIHHEESEMETEEEVDILMSSDIYSATLSTKSISFTRAQTGWLFREDKTERVGNFLADFYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGSLAEQSFEPVRRQSLTPPPQNTITWEEYISAENGKAPHLGRELVCKESKKTFKATVAMSQEFPLGIESLLNVLEVIAPFKHFNKLREFVQMKLPPGFPVKLDIPVFPTITATVTFQEFRCDEFDGSIFAIPEDYKEDPSRFPDL", "function": "Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.", "AFDB_id": "AF-Q3UX43-F1-model_v4" }, { "swissprot_id": "P38290", "sequence": "MAYSLTRKLLKDWKYFMRHPEKTQGLFHVRPHDSDLHLWHVVMYEPRTSLEVYLLLYIGGNDQDPYIIMKCLSPNCCFPINRTVSMTHLNYLLLKDLGLQDLLFHIWQPLFHIQATEDLQYSPSTVKFNRAWNRIIYKDFKSYFPELIGTLQPGDYSIVKSYSKNHNISNSNGGSVNEFMSSYNAQSHTFHAQDNSKNPYTNSSIGKSSMLSTLNNNNVNKRTHDYNAIDFMTKNLLACDDDSIHPVVSSKRSRTLACPDETNDNRGSEHYTKRKKI", "function": "Not known; its elevated expression suppresses the conditional cell cycle defects associated with UBC3/CDC34 mutations.", "AFDB_id": "AF-P38290-F1-model_v4" }, { "swissprot_id": "Q8MNU7", "sequence": "MLPDLSPHLHTKECNMLIEFLQRCHSEKPIGKMIGKCSYWDEAVWQCTKKERIWRRDNNPAYKRRIVELRSLPEKYWTPALHKLKEDGVLIGGADQSQGCKI", "function": "May be involved in cytochrome c oxidase biogenesis.", "AFDB_id": "AF-Q8MNU7-F1-model_v4" }, { "swissprot_id": "Q833J1", "sequence": "MSNGKKIFISHSSKDQEYVDAFIQLLKKFGFRTQDIFYSSTIETGVQPGELIFDTIKRELTNQPVMLYFLSDHYYQSIPCLNEMGASWMLSDKHYPIALNNFSMKDMKGVISSERLAIAFNDKTSTNEINCLLKKLSHDTDVQAEPDFELNVEKNIQPFQNKLTQLIRQASYLKPDEKGYFETILSTHRPVYGTAKGVYDCFKLPSLIEPKSLGLDTLSEDESHWLFFFLTWGTFQEGEKVRFKLKKDKAYNNREFSDIGKCKNIYVSYLEKVE", "function": "Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection. Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. Interacts with various phosphatidylinositol phosphates, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P), phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P), and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P).", "AFDB_id": "AF-Q833J1-F1-model_v4" }, { "swissprot_id": "Q6C6Q7", "sequence": "MSSLPTPLPPYKWTLLTAGNANVVYKSDETDLLLRLRRNRNAPSTAEVDEYLTGTIRPAIGPFLFHYTVVNLPLGFLESLPEAENLDLGEPLGLLMENLGPKPNETNVLKSHAVKINYSDNWESYTVELKPKWLLQSPTAPKDSINCRTCALQLKREKPRICPLKLFNEDEQTSLQALEDVFPGTQKQFEPLAKFFSNSELFAEIRHMQHGDELGILGYANYVQVPPQFVTAMTMRDVSLFVHVQGDSVNGKIVDADLKSVSEKRDYWASLETDLIEGGWYEKPGTNCLLRN", "function": "Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.", "AFDB_id": "AF-Q6C6Q7-F1-model_v4" }, { "swissprot_id": "A0A0H3CC30", "sequence": "MKKHRLPDTELARIAPLAPDARRKALLKFKNGFPDFSYEPTRRRLPELTNAQPSLLSLGDTEWSKIESGLKRLKNEKEAASNIEVAELLYNFIREEKYIAVMEPFGKLQLGAGVAISYWSDAIFFGPDGPTIFGFDFRRAGGFNDSARRFAFSAQHEHIRQRGDDYATAKLGLVQFPALRNGTRKVRVEFADQVELIPYDELIQMARETYSVWFEILEQREDEARKTGTGGSWWDGD", "function": "Toxic component of an atypical type II toxin-antitoxin (TA) system. Upon overexpression in the absence of its cognate antitoxin SocA, leads to inhibition of colony formation, cellular filamentation, incomplete DNA replication and induction of the SOS response. Exercises toxicity by binding the beta sliding clamp (dnaN), blocking DNA replication and leading to premature replication fork collapse and incomplete cell division. Unlike most type II TA systems, the SocB toxin is unstable and targeted by its cognate antitoxin SocA for degradation by ClpXP. Not toxic upon expression in E.coli.", "AFDB_id": "AF-A0A0H3CC30-F1-model_v4" }, { "swissprot_id": "Q95MG6", "sequence": "MSAVNGTPWGSSAREEVWAGSGVEVEGSELPTFSTAAKVRVGVTIVLFVSSAGGNLAVLWSVTRPQPSQLRPSPVRRLFAHLAAADLLVTFVVMPLDATWNITVQWLAGDIACRTLMFLKLMAMYAAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLALPQLFLFHTVHRAGPVPFTQCATKGSFKARWQETTYNLFTFCCLFLLPLTAMAICYSRIVLGVSSPRTRKGSHAPAGEFALRRSFDNRPRVRLRALRLALLVLLTFILCWTPYYLLGLWYWFSPSMLSEVPPSLSHILFLFGLLNAPLDPLLYGAFTLGCRRGHQELSMDSSREEGSRRMFQQDIQALRQTEVQKTVTSRKAGETKDIPITSI", "function": "Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.", "AFDB_id": "AF-Q95MG6-F1-model_v4" }, { "swissprot_id": "Q2S2B6", "sequence": "MSHDPMNPHLQSSADPSRSSEEIRQDFLQFFQAKGHEVVPSASLVPDGDGTLLFTNAGMNQFKDVFLGTGQRPYSRAVDTQKCLRVSGKHNDLEEVGHDTYHHTFFEMLGNWSFGDYFKAEAIRWAWELLVERWGLAPDRLYATVHEGDDDFGLSADAEAYDLWLSETPLPEERVLYEPSKENFWMMGDTGPCGPCSELHVDLRPPEARQETPGRELVNVDHPQVMELWNLVFIQYNAQTDGSLEPLDDQHVDTGMGFERMVAVLQGKESTYDTDLFAPLLQAMADRSPREEIRGYDDLHIEDDDEHEQVRIALRVVADHIRAIAFAISDGVMPSNEGRGYVIRRILRRAVRYGYQTLELEEPFLHRLVDPLIEKMGGPFDGLAEQQEFIEQAIRSEEESFLETLGTGIEFFERVVPHVTGFQDTDGEESDRLLGALREDAQAMDLLEKAYVDTDDENDILHSFARTARGGTLPGQIAFLLHDTYGFPIDLTRLMARERDLDVDMEGYETLMDRQQERARAASDFAVDQSDVQAWQSVSPGEASVFVGYDRAVVPDAEVRAVRVVETGDTQQYEVELSRTPFYAEAGGQVGDTGTLRFGDESVQVLDTQREGERIAHTVDTLPEPLDGPVEAAVDAERRNHIRAHHTATHLMHAVLRETLGDHVQQKGSLVAPDRLRFDFSHFDAVDEDTLRHIERRVNTAIQQNIPKQEARDVPIDEALDRGATALFDEQYGDRVRVITFDPDFSMELCGGTHVDATGEIGLFRFLSEGSVASGVRRVEAVAGKAALEHVESELETLTRARRQFRSLHTSLPEAIAEVQEERDRLAGEVDQLRRGQLSDQLDTFIAENAASVDGITVVTGRLDRASMDDLQELGQQFRDKLGEGAVGVLGSVGEDGEKAYVVATVADDLVDDGALRAGDLVGTLGDRLGGGGGGRPSLASAGGRDPEALDTVLDGVPALVRDRLE", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.", "AFDB_id": "AF-Q2S2B6-F1-model_v4" }, { "swissprot_id": "Q80UW0", "sequence": "MALPAFAARALGPPLQPEQGAPARTTCPRRHSRVEAELAASRPGSVAASVRAGPPRGVSLGFNSPPLQDKPPKAFSSLAGALRAPLFALLPRGRRRRMHDLRRRWDLGSLCRALLTRGLAAVGHSLKHVLSAIFSKIFGPLASVGNMDEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFSRGDLLRKVDFDIKGDDLIVFLHIQKTGGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPAVVDGKRDARLRPSRNFHYITILRDPVSRYLSEWRHVQRGATWKASLHVCDGRPPTSEELPSCYTGDDWSGCPLKEFMDCPYNLANNRQVRMLSDLTLVGCYNLSVMPEKQRNKVLLESAKSNLKHMAFFGLTEFQRKTQYLFEKTFNMNFISPFTQYNTTRASSVEINEEIQKRIEGLNFLDMELYSYAKDLFLQRYQFMRQKEHQDARRKRQEQRKFLKGRFLQTHFQSQSQGQSQSQSPGQNLSQNPNPNPNQNLTQNLSHNLTPSSNPNSTQRENRGSQKQGSGQGQGDSGTSNGTNDYIGSVETWR", "function": "6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.", "AFDB_id": "AF-Q80UW0-F1-model_v4" }, { "swissprot_id": "Q3JAC4", "sequence": "MLIEQLWTANAYRNFNYLIACPETGEALAIDPLDHRQCLATAKRNGWRITQIFNTHEHGDHTGGNEAIIAQTKGKLLAHHKARDKIRGIDEGLAAGDTVKVGNGVALKVLDTPGHTMSHLCLFAPSNPPALFCGDTLFNAGAGNCHNGGDPNALYATFTQQLALLPCNTRIYPGHEYIENNLGFTLDREPDNEQAMALLAEVKSQDPNHAFVSTLALEKEINTFFRLDNPTLITKLRETFPDLPRVPDPKTVFLKLRELRNKW", "function": "Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.", "AFDB_id": "AF-Q3JAC4-F1-model_v4" }, { "swissprot_id": "B1XPE2", "sequence": "MTPATPLNLLISNDDGISALGIRTLANTLAEAGHQVTVVCPDRERSATGHGLTLHRPIRTEIVEGIFDPRVTAWSCSGTPSDCVKFALSAVLKERPDFVLSGINHGSNLGTDVLYSGTVSAAMEGLLEGIHSIALSLADYTSHNFQPAADFAVKLLCQLMEKRPHWAIANQDAPVLLNINVPNLEKEKLAGVKITRQGLRRYIEQFQKRQDPRGKTYYWLSGEVIEELPQPDEPNIPLDFPTDVQAIAAGYITITPLQYIMNDLHRIQTLAQEDWQI", "function": "Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.", "AFDB_id": "AF-B1XPE2-F1-model_v4" }, { "swissprot_id": "A9KPL0", "sequence": "MQGKKQRITQLTELLDEAARVYEQEDREIMSNFEYDKLYDELKKLEEETGIVLAGSPTRKVGYEILSELPKERHESAMLSLDKTKEVPALIDWLGNKEGILSWKMDGLTIVLTYRNGELVKAVTRGNGEVGEVVTNNAKVFKNLPLTIPYEGELIIRGEAVIRYSDFEMINAQIPDADAKYKNPRNLCSGSVRQLNNAITAKRNVNFFAFALIRMDEMNRFKTMMEQFNWLKELGFDVVEEKLVTAENMAETMEYFESHIITNDFPSDGLVLFFNDIAYGESLGRTSKFPRNGIAFKWRDEIKETTLQEIEWSASRTGLINPVAIFEPVELEGTTVSRASLHNISIMEGLELGLGDKVTVYKANMIIPQIADNLTRSGHLPIPKTCPVCGGDTMIKQDSDVKSLYCMNPECLAKKIKSFTHFVSRDAMNIEGLSEATIEKLIAKGLIKELADIFHVKDFKEEITTMEGFGEKSFRNLVDSVEKARTPILAKFIYSLGIANVGLANAKLICKEFGYDFNKVSNATVDELTQIPQIGYVIAEAFVSYFQKPENKLIIEDLLKEITFEKEEAAGGSEKLKGLTFVITGSVEHFTNRNEVKDVIEQHGGKVTGSVTAKTNYLINNDNTSSSSKNKKARELGIPVITEEEFIQLLNEA", "function": "DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.", "AFDB_id": "AF-A9KPL0-F1-model_v4" }, { "swissprot_id": "Q04377", "sequence": "MRRETVGEFSSDDDDDILLELGTRPPRFTQIPPSSAALQTQIPTTLEVTTTTLNNKQSKNDNQLVNQLNKAQGEASMLRDKINFLNIEREKEKNIQAVKVNELQVKHLQELAKLKQELQKLEDEKKFLQMEARGKSKREVITNVKPPSTTLSTNTNTITPDSSSVAIEAKPQSPQSKKRKISDNLLKKNMVPLNPNRIIPDETSLFLESILLHQIIGADLSTIEILNRLKLDYITEFKFKNFVIAKGAPIGKSIVSLLLRCKKTLTLDRFIDTLLEDIAVLIKEISVHPNESKLAVPFLVALMYQIVQFRPSATHNLALKDCFLFICDLIRIYHHVLKVPIHESNMNLHVEPQIFQYELIDYLIISYSFDLLEGILRVLQSHPKQTYMEFFDENILKSFEFVYKLALTISYKPMVNVIFSAVEVVNIITSIILNMDNSSDLKSLISGSWWRDCITRLYALLEKEIKSGDVYNENVDTTTLHMSKYHDFFGLIRNIGDNELGGLISKLIYTDRLQSVPRVISKEDIGMDSDKFTAPIIGYKMEKWLLKLKDEVLNIFENLLMIYGDDATIVNGEMLIHSSKFLSREQALMIERYVGQDSPNLDLRCHLIEHTLTIIYRLWKDHFKQLREEQIKQVESQLIMSLWRFLVCQTETVTANEREMRDHRHLVDSLHDLTIKDQASYYEDAFEDLPEYIEEELKMQLNKRTGRIMQVKYDEKFQEMARTILESKSFDLTTLEEADSLYISMGL", "function": "Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Required for the recruitment of MEC1 to DNA lesions, the activation of CHK1 and RAD53 kinases and phosphorylation of RAD9 in response to DNA damage. Required for cell growth and meiotic recombination.", "AFDB_id": "AF-Q04377-F1-model_v4" }, { "swissprot_id": "Q6MTB9", "sequence": "MGFWAKLKEKLTKKTNQVEQDEPILDQQDQQDQQEEQEQIIEKEIEQIKENKIKKTKTSETKKQEKPIETLKEKKKREKQKEKDKKVEKAMLKSAFNFSKDIKKLSKKYKQADDEFFEELEDVLIQTDMGMKMVLKVSNLVRKKTKRDTSFENIKDALVESLYQAYTDNDWTNKKYRIDFKENRLNIFMLVGVNGTGKTTSLAKMANYYAELGYKVLIAAADTFRAGATQQLEEWIKTRLNNKVDLVKANKLNADPASVVFDAIKKAKEQNYDLLLIDTAGRLQNKVNLMAELEKMNKIIQQVEKSAPHEVLLVIDATTGQNGVIQAEEFSKVADVSGIILTKMDSTSKGGIGLAIKELLNIPIKMIGVGEKVDDLLAFDIDQYIVHLSSGFMQGDEVEK", "function": "Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).", "AFDB_id": "AF-Q6MTB9-F1-model_v4" }, { "swissprot_id": "A0A0R4IWG9", "sequence": "MDPGTLSLFQRVSTKLGWDRDGGLDDAEEKLRKSLKKTRRPALASSDSSTGPAQRLELSDSDNSSGKENRSQEEHILLTSDDEDFEKFLASKATPKSTFKQSASSAQKPREPVPVLSSESDNEFELFLNRVKTPKAKVQPQSMSSSDESLKHFIVDSMSSDDDFVTEKKPSIYKGKAKTVKTPKSVQKTKKPAPSLCNSPVFLSDSDDDCNIVIKSTWRTRHSRPPSDEHQATSKDREETEKPRVPQPTITVKSHTSRDDTCSSEEEFQSLLDRVRQNLGGRTSASPMPSAEPKPQRPCLSTPSATGRKTGSQVPVKDSPVIHTPVQQMPSSRPVLSHTEPRALPNSRVVVCKTPGCFLQSLSAPGSVYCRSFKQNKDELTSKLYQLYNTSVFDSQLPVDMSVTWNNKMRKTAGYCISGQERGTGKRYARIELSVKVCDSADRLRDTLIHEMCHAATWLINNVRDGHGPFWRLYARKAMLAHPELPMVSRCHSYDINYKFQYQCNRCKNTIGRHSKSLDTTKFVCALCTGQLVLLTPSKPRAPTPFATFVKENYGSTKQELTGQSHAEIMRKLSADFASKTRLSQS", "function": "May play a role in DNA-protein cross-links (DPCs) clearance, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage.", "AFDB_id": "AF-A0A0R4IWG9-F1-model_v4" }, { "swissprot_id": "B0XTJ7", "sequence": "MGSKSPEGHRQAPHASNCNELKPANPDPQISQNGSGSADLDRGVIGDDDDDEDAEENGVNTETPNVGKLNQPPFPNLDQVHVTTTDGLCITEKKKKRKKSNKKKKKTKSGALPATELKQTSPPRVLVSTLFPSEYPVGELVPYDCTARTTDEELRYNSRLWDDDFLPDYRQAAEIHRQVRQYAQKELIKPGATLLSIAEGIEDGVRALSGHQGLEPGDFFKAGMGFPTGLCLNHIAAHWTPNPREKDVILDKGDVLKVDFGVHVNGRIVDSAFTVAFDDKYDNLLTAVREATNTGIKHAGVDARMSDIGAAIQEVMESYEVEIDGKVFPVKAIRNITGHDILRYHIHGGKQIPFIKNNNQDKMEEGEVYAIETFGSTGRGFLDDDVGVYGYGRNENMSGANLRLSSAKSLLKTIDASFGSIVFSRRYLERLGVKNYLLGMKNLIDNGIVECYSPLVDVKGSYTAQFEHTILLHSGGKEVISRGDDY", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).", "AFDB_id": "AF-B0XTJ7-F1-model_v4" }, { "swissprot_id": "P06182", "sequence": "MGWFWADQKTTGKDIGGAAVSSMSGCPVMHESSSSSPPSSECPVMQGDNDRINPLNNMPELAASKQPGQKMDLPVDRTISSIPKSPDSNEFWEYPSPQQMYNAMVRKGKIGGSGEVAEDAVESMVQVHNFLNEGCWQEVLEWEKPHTDESHVQPKLLKFMGKPGVLSPRARWMHLCGLLFPSHFSQELPFDRHDWIVLRGERKAEQQPPTFKEVRYVLDFYGGPDDENGMPTFHVDVRPALDSLDNAKDRMTRFLDRMISGPSSSSSAP", "function": "Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.", "AFDB_id": "AF-P06182-F1-model_v4" }, { "swissprot_id": "Q05892", "sequence": "MIPKLIVFGGNGFLGKRICQEAVTSGYQVVSVSRSGKAPHSNELNDKQWMQEVQWTAADIFKPDSYHELLNNATNVVHSLGILLENENYKQTLSKSPTYDSKSRLLSFGAGPNPLKKSSPYFTYEMMNKQSAIILADTFKQKILKKSKKEQEKANQRSFTYISADKGFPLIPSGYINSKREAEIELEKMQRYFRPIIVRPGFMFDEHRNAIGPRSFIHTALELLYCGNKFLLRNKLQLLNDLIRPTVSTQQVSKSVLKNIENPDFKGVVTLEEILKA", "function": "Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression. Component of a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.", "AFDB_id": "AF-Q05892-F1-model_v4" }, { "swissprot_id": "A0LE53", "sequence": "MEQEWLQVRKKLQRSLSKGQYDLWVSTLEFLGIEDGNLILGCQNRFHIEWLREKLEAKLLPIASQHFRGVRKLEYRVAQGCAAGAPEIEGAGPRQIAFSDVVKCVGPAFNPRFTFDHFVVGGCNQFAYAAAMGMANNQQLYNQSVYLLSDTGLGKSHLTHAVGNYLRNRKPELRVQYVTTEQFANEMIFSLKNGNMEAFKNKFRTGCDVLLLEKIEFLSGKEKIQKELVYTLDELMDRGKTVLCTGNAYPKDIPKLNSELQSRLGGGLLAPIDKPDFKTRIEIIKRKSHTENIRVPMEVVEYLADRITGDVRQLESCLVGLMAKSNILRTPITLDLAREVSQTMLDQLPKISVEQIQKIICANFRITLEELRSTSRRKQVALARKIGIYLSREYTTESLQSIGKSFQRSHSSVLYAVNEVQKGMGEANGRLKREVEYLSRRLETSCLSES", "function": "Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.", "AFDB_id": "AF-A0LE53-F1-model_v4" }, { "swissprot_id": "Q9V3S0", "sequence": "MAVEVVQETLQQAASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGKSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENGFNVSLEKRQYATVA", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9V3S0-F1-model_v4" }, { "swissprot_id": "O46202", "sequence": "MTDMWSLKICACLGLLLLFKPIDSMGWQGPKVDCTANGTQTECPVACPETCEYSGNGPCVKMCGAPCVCKPGYVINERIPACVLRSDCPKDVVRKEDMLLGVSNFKCFSRNYNCS", "function": "Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release.", "AFDB_id": "AF-O46202-F1-model_v4" }, { "swissprot_id": "Q61826", "sequence": "MESILALLLALALVPYQLSRGQSFQVNPPESEVAVAMGTSLQITCSMSCDEGVARVHWRGLDTSLGSVQTLPGSSILSVRGMLSDTGTPVCVGSCGSRSFQHSVKILVYAFPDQLVVSPEFLVPGQDQVVSCTAHNIWPADPNSLSFALLLGEQRLEGAQALEPEQEEEIQEAEGTPLFRMTQRWRLPSLGTPAPPALHCQVTMQLPKLVLTHRKEIPVLQSQTSPKPPNTTSAEPYILTSSSTAEAVSTGLNITTLPSAPPYPKLSPRTLSSEGPCRPKIHQDLEAGWELLCEASCGPGVTVRWTLAPGDLATYHKREAGAQAWLSVLPPGPMVEGWFQCRQDPGGEVTNLYVPGQVTPNSSSTVVLWIGSLVLGLLALVFLAYRLWKCYRPGPRPDTSSCTHL", "function": "Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.", "AFDB_id": "AF-Q61826-F1-model_v4" }, { "swissprot_id": "P39782", "sequence": "MTKRTIEQILDELRRGRRPLLADKPAESDASRYDCLRCKDQGGYLVRQNGLEVWTMCSCMAERKVKRLLGASEITHAFRQLGFKEFRTEGKPQAIKDAFECTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELMRTCYVPVIYFPFVEGFTDLKNDFALLEAKLNRMKQADVLFIDDLFKPVNGKPRATDWQLEQMYSVLNYRYLNHKPILLSSELTIEGLVRVDEALGTRIYEMCSDYLVIIKGAAYELNHRLEGVR", "function": "May function as a transcriptional antiterminator.", "AFDB_id": "AF-P39782-F1-model_v4" }, { "swissprot_id": "P39583", "sequence": "MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYNLIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIYNVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTIAMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD", "function": "Functions as a (p)ppGpp synthase; GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis. Overexpression in relA mutants (triple relA-yjbM-ywaC deletions and single relA deletions) leads to growth arrest; GTP levels fall drastically, various guanine-related nucleotides are synthesized (ppGp or pGpp), the cellular transcriptional profile changes dramatically and 70S ribosome dimerization occurs. Overexpression in the presence of a wild-type relA gene does not have these effects. In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. activities in response to changes in nutritional abundance. YwaC has probably a minor role in stringent response.", "AFDB_id": "AF-P39583-F1-model_v4" }, { "swissprot_id": "Q04437", "sequence": "MSSESTTFIVDVSPSMMKNNNVSKSMAYLEYTLLNKSKKSRKTDWISCYLANCPVSENSQEIPNVFQIQSFLAPVTTTATIGFIKRLKQYCDQHSHDSSNEGLQSMIQCLLVVSLDIKQQFQARKILKQIVVFTDNLDDLDITDEEIDLLTEELSTRIILIDCGKDTQEERKKSNWLKLVEAIPNSRIYNMNELLVEITSPATSVVKPVRVFSGELRLGADILSTQTSNPSGSMQDENCLCIKVEAFPATKAVSGLNRKTAVEVEDSQKKERYVGVKSIIEYEIHNEGNKKNVSEDDQSGSSYIPVTISKDSVTKAYRYGADYVVLPSVLVDQTVYESFPGLDLRGFLNREALPRYFLTSESSFITADTRLGCQSDLMAFSALVDVMLENRKIAVARYVSKKDSEVNMCALCPVLIEHSNINSEKKFVKSLTLCRLPFAEDERVTDFPKLLDRTTTSGVPLKKETDGHQIDELMEQFVDSMDTDELPEIPLGNYYQPIGEVTTDTTLPLPSLNKDQEENKKDPLRIPTVFVYRQQQVLLEWIHQLMINDSREFEIPELPDSLKNKISPYTHKKFDSTKLVEVLGIKKVDKLKLDSELKTELEREKIPDLETLLKRGEQHSRGSPNNSNN", "function": "Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.", "AFDB_id": "AF-Q04437-F1-model_v4" }, { "swissprot_id": "Q9FNP1", "sequence": "MSRNRQIIIPDDVMETEAVVNTVAGVDCFVSLPRQLLHALQSTSSSPLPPLLPVELRSGDRRWSVAWSGSSSSSSAIEIARVFAESISLPDGTVVKVRVLPNVPKATLVTVEPETEDDWEVLELNAELAEAAILSQVRILHETMKFPLWLHDRTVIRFSVVSTFPSKGVVQLVPGTEVAVAPKRRDRNLKAKKSQEKECNNVKALLRVQETDRSAFHEADVKGFELRVALTSIAYIHPETAKKHSLESLQLISVSPRIPLKGSAKKDEALNMKNSEASKVAENGTSSAKKEPRQAILRLVFSDLAAKGHLMMVESLRLYLGAGLHSWVYLRGCNVNEDKEIPALSLSPCVFKISENEKVLDKGTDRLGNNNSVRKSSHPPSGLSTYVDVVDWSVHDKVVTALSSEGLHDEGNHDKNKKGLEYLTRLWSLAQLDAMASVTGVDVSSLIVGRETFFHFEVRGLESYKSIDGQPSVNDRWESGKKDKHTPLEILYVMTVSDESLLGDKFAGYDLSLDRSEKSDNVVHIEPVLEKMNLGEPIYLKSAKETHCNKGVSPDISSLTWMGPIVSDVIKRMTVLLSPAAGMWFSKFKIPSPGHILIYGPPGSGKTILARAAAKYFEEQKDLLAHVILVSCSTLALEKVQHIHHVLSSVIAEGLEHAPSVIILDDLDSIISSSSDTEGTQASVGVTMLTKFLTDVIDDYGEYRNSSCGIGPLAFVASVQSLEQIPQTLSSSGRFDFHVQLAAPATSERGAILKHEIQKRLLDCSEDILLNLAAKCEGYDAYDLEILVDRAVHAAIGRHLPLESNISKYNLVKEDFTRAMHDFVPVAMRDITKSASEGGRLGWEDVGGVTDIKNAIKEMIELPSKFPKIFAKSPLRLRSNVLLYGPPGCGKTHIVGAAAAACSLRFISVKGPELLNKYIGASEQAVRDIFSKAAAAAPCILFFDEFDSIAPKRGHDNTGVTDRVVNQFLTELDGVEVLTGVFVFAATSRPDLLDPALLRPGRLDRLLLCDFPSPPERLEILTVLSRKLLMADDIDLEPIALMTEGFSGADLQALLSDAQLAAVHEYLNREDKPETGTTPIITDPLLKSIASKTKPSVSETEKQKLYDIYSQFLDSRKSSREAKGKRATLA", "function": "Involved in PTS1- and PTS2-dependent protein import into peroxisomes. May form heteromeric AAA ATPase complexes required for the import of proteins.", "AFDB_id": "AF-Q9FNP1-F1-model_v4" }, { "swissprot_id": "O28787", "sequence": "MPLKFRIKHTLDRMRVGKVKTRHGSFETPVFIPVATLAAIRGLDNRDLKDMGVEVILANTYHLHLRPGDELIKELGGLHKFMNFDGVIVTDSGGFQAFSLGFGMEHGVGKIANNIFLEELREERLREAENERKKLAVVTDRGVRFKDPKSGRIVELTPKKSMEIQSNLGSDIIFAFDECTSPLSDRDYTEKALERTHRWAEECLQHYDRRQALFGVVQGGEYRDLREKSARFMAERDFAGYGIGGSLGKSKQDMLNILDWVIPLLPEEKPRHLLGIGAIEDLFNCTEKGVDMYDCVAPARWARRGHLYVSPAEGGNVRNKFRIHIKNAAFRIDNRPVDRTCDCLVCQNYSRAYLRHLYKANELLYFRLATYHNIYFVVKLMERIRESIADGSFYELKREWLGF", "function": "Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).", "AFDB_id": "AF-O28787-F1-model_v4" }, { "swissprot_id": "P46000", "sequence": "MNKYPPLLTMLIIGIGSNAVAGDYFDPSLLATDIGNNDKLDLSLFSHPGGGVKGEREVSVYINDFFYKNVTLDFENGISGALEPIFPSGFFDNILASPYRSIKEKELISTADFLSLVPYGMVRFDQAIARVDISIPQAYLGRDAQMKSAPESWNQGVPALLIDYRLSGSKNKYNYGSSQNFYANAFLGFNLMGWRLRTTTNYMSYNSKDLYNKGERQGSFNFYNTYLEKDIGYLRSTLRLGELSTRGMILESFNFKGGKIYSNDEMLNDRLRSYTPTVRGIASSQAVVTIKQGGVVILQKNVPPGPFEINDFSLSGYSGDLYVNIKEADGSEHSFIQPFSTLPEMKREGVSGYEISLGHYNNSGATQYYNESPFLYASWSRGYRNGMTLYSETIQSRKYQLLGVGSTLSLGDFGAVSGDASLSRANKYDKIHSGQSYGLKYSKNKVDTGTTVTLATYRYSTKDFYSFNDFVSKNDSVQYVWDNRLKNRITLSLNQSLDDYGSLSLIASQQNYWTSDYVSRSFSLSHSFGWNDIFFSTSFSLDQKEGDNALRNNNKVFGFYSSIPLSKLIGKNESTYSTLSYNVTKINNQVRNTATLAGKVPGSMAQYRFSSGWANTEQSSNKALSVNWDGDLLDGSLGYTSSGKNRITDYSLSGSAILYPWRLAIGSDSVINGAAVVETEFISGIKVRQGGETSLLGTAIVTSMQPYTENRIDLDTQNIPDDLFISNASKKIVPEKGAVVPVKYNLFKGKQIVFSLKRYDGTPLPFGSVVSLVGSDSEITGIIDDAGRVYLAGIPSKGILHGAWGYNKSCEVSFNLNGKPSNNSNEIIEYEGVCK", "function": "Involved in the export and assembly of the 987P fimbriae subunits across the outer membrane.", "AFDB_id": "AF-P46000-F1-model_v4" }, { "swissprot_id": "Q8RGE3", "sequence": "MPSFDVSVVTQVKKILEQEAGYLRLRTSEGDIGILPNHAPFVAELSMGKMEIESPNKDRRDIYFLSGGFLEISDNQATVIADEVFPIEKIDVESEQALVENLKKELEKVSTEEEKRKLQKKIKISLAKIDAKNN", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-Q8RGE3-F1-model_v4" }, { "swissprot_id": "Q9LD37", "sequence": "MASHNENDDIPMLPISDPSSRTRARAFTSRSRSVSLSNPTSSIEGFDTSTVVLGYTGPLRTQRRPPLVQMSGPLTSTRKHEPLFLPHPSSDSVGVSSQPERYPSFAALEHKNSSEDEFVLKHANLLRSGQLGMCNDPYCTTCPSYYNRKAAQIPTSRVSALFDSTFHNALYDDAKGWARRFASSVNRYLPGIMNPHAKEVQTWTKFFALSCLLAIFIDPLFFFLIKVQEQNKCIMIDWPMTKAFVAVRSVTDVIFTMNILLQFRLAYVARESTVVGAGQLVSHPKKIALHYLKGKFFLDLFIVMPLPQILILWIIPAHLGASGANYAKNLLRAAVLFQYIPKLYRLLPFLAGQTPTGFIFESAWANFVINLLTFMLAGHVVGSCWYLFGLQRVNQCLRNACGNFGRECQDLIDCGNGNSSVLVRATWKDNASANACFQEDGFPYGIYLKAVNLTNHSNLFTRYSYSLFWGFQQISTLAGNQVPSYFLGEVFFTMGIIGLGLLLFALLIGNMQNFLQALGKRNLEMTLRRRDVEQWMSHRRLPDGIRRRVREAERFNWAATRGVNEELLFENMPDDLQRDIRRHLFKFLKKVRIFSLMDEPILDAIRERLKQRTYIGSSTVLHRGGLVEKMVFIVRGEMESIGEDGSVLPLYEGDVCGEELLTWCLERSSVNPDGTRIRMPSKGLLSSRNVRCVTNVEAFSLSVADLEDVTSLFSRFLRSHRVQGAIRYDSPYWRLRAARQIQVAWRYRRRRLHRLCTPQSSYSL", "function": "Probable cyclic nucleotide-gated ion channel.", "AFDB_id": "AF-Q9LD37-F1-model_v4" }, { "swissprot_id": "P16640", "sequence": "MNANDNVVIVGTGLAGVEVAFGLRASGWEGNIRLVGDATVIPHHLPPLSKAYLAGKATAESLYLRTPDAYAAQNIQLLGGTQVTAINRDRQQVILSDGRALDYDRLVLATGGRPRPLPVASGAVGKANNFRYLRTLEDAECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLDTAARVLERVTAPPVSAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGTRLPADLVIAGIGLIPNCELASAAGLQVDNGIVINEHMQTSDPLIMAVGDCARFHSQLYDRWVRIESVPNALEQARKIAAILCGKVPRDEAAPWFWSDQYEIGLKMVGLSEGYDRIIVRGSLAQPDFSVFYLQGDRVLAVDTVNRPVEFNQSKQIITDRLPVEPNLLGDESVPLKEIIAAAKAELSSA", "function": "The oxidation of camphor by cytochrome P450-CAM CamC requires the participation of the flavoprotein, putidaredoxin reductase CamA, and the iron-sulfur protein, putidaredoxin CamB, to mediate the transfer of electrons from NADH to P450 for oxygen activation.", "AFDB_id": "AF-P16640-F1-model_v4" }, { "swissprot_id": "O65660", "sequence": "MARRDVLLPFLLLLATVSAVAFAEDDPDCVYTFYLRTGSIWKAGTDSIISARIYDKDGDYIGIKNLQAWAGLMGPDYNYFERGNLDIFSGRAPCLPSPICALNLTSDGSGDHHGWYVNYVEITTAGVHAQCSTQDFEIEQWLATDTSPYELTAVRNNCPVKLRDSVSRVGSEIRKKLSWVV", "function": "Positive regulator of abiotic stress tolerance involved in the regulation of plant growth. May be a downstream target of the abscisic acid (ABA) signaling pathway.", "AFDB_id": "AF-O65660-F1-model_v4" }, { "swissprot_id": "Q03017", "sequence": "MPSPTKAAEAATKATATSDCSCSAASVEQRAPSNAANPSSSLATSGKIGGKTQDQTAAINKQKEFAVPNETSDSGFISGPQSSQIFSEEIVPDSEEQDKDQQESAPQKEQPVVLDSGIIDEEEDQEEQEKEEEHQDTTTATADSMRLKHSADTGIPQWTVESHLVSRGEQLNNLGQSSSTQITGRSKVQSSTASTANANPSGSGATSSAPPSSINIMNAWEQFYQQNDDGDTPLHLACISGSVDVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSYACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAETVTPPDSDYDSSDIEDLDDTKMYDRFGDPRYFVSYNGGNPMTVA", "function": "Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation.", "AFDB_id": "AF-Q03017-F1-model_v4" }, { "swissprot_id": "Q02256", "sequence": "MAGNANSVDEEVTRILGGIYLGGIRPIIDHRPLGAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLFPNEVEYSPRLVDFKKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMGGDFVDFDNPAYKQWKLKQSIKLDPSGSELVSNSGMFKDSESSQDLDKLTEAEKSKVTAVRCKKCRTKLALSTSFIAHDPPSKESSEGHFIKRAANSHRIIDIQESQANCSHFFIEPLKWMQPELQGKQELEGKFSCPGCSSKVGGYNWKGSRCSCGKWVIPAIHLQTSKVDQFPLQSTALPNMVNFESEKVNR", "function": "May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.", "AFDB_id": "AF-Q02256-F1-model_v4" }, { "swissprot_id": "Q9NZJ0", "sequence": "MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPINRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQAEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSKDSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENKNWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQEDFCGPEHSTEL", "function": "Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1.", "AFDB_id": "AF-Q9NZJ0-F1-model_v4" }, { "swissprot_id": "P21242", "sequence": "MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVPQKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPAFADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYKGAATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHEDNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEINGDDDEDEDDSDNVMSSDDENAPVATNANATTDQEGDIHLE", "function": "The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.", "AFDB_id": "AF-P21242-F1-model_v4" }, { "swissprot_id": "P32744", "sequence": "MSRVISRSTPGGTCIVSKDDFLKSFEEVPKMEISSPSDFKEKLDQTIETLSKGQEDWNKRMNKLKQIRSMVVHGEDVIGREQLLSQLVRLTDCLDLSVKDLRSQILREAAITCGFLFKRFGTDVRQIAERCLPSAFAQVAVSTKVMATCGAVLTLFIVEFIQTKQIFTCIASYSTSKDKNQRRQLCALLEIVLEHWNEKIKRTVLPQIGELIKAAICDADPETRVAGRKAFSKLDALHSTEADKLFASVDSSKQKMLRASDAASSSTSINSERGTAPFRSKLSAGSIGGIRNAPNISSKFLAQRSASAIDTKQVTRMATSVSRTPNIRPMTTRTLSKIDTSPGGSKFARPTVGALGSRTSSNLRARGSVPTSQPGSRNGSPPRRPSATEAFPAEMQRVKSNLGSNSFVSSLSAEEATKLQKAMNTAKESLRQPSRNDDDEFLLPKRPTPQKATPQKSALDTSRVEEVIRACSSTSANEKREGIKMLAGIVSEPNLSNAEIKSLGAVLNRLLGESTNQIVLESISSFVKTHHPRLSDWLKLGLGKLFAKKGAEMTLNSKKQISTTISCILSSFDPTLQLKSTCELVCDPIHLMSPKSRVVLLEYLNELLGKYMERGSSFNTKEMKATILKMFSWMADQRNEQLITPHGEKVLCSLFALNNADFSALFNDFNPDYRDWAYKVLQSHGHDQHVPQQDAVSEEACVRATISTTAAQIEDFVVSRNLDMTPVKSPSTRAISSGFKRVDAEPLRPLSSEMNSQHRDEELSFNESFDRLKLNSTTHLIDDTSEQSKYVASKLAQISGDMGAQQYEGLLSIQTMLCEGSFTLWEQNFAKLLIAVFDVLSKSESDANKKVALRVLTKMCTSQASRLFDSTEMAICKVLDAAVNSQDGTMNVTADDCLKTLATHLPLAKVVNISQLILNEEKAQEPKASLVLKMMTRLFEGLQADELSPVVDDLAPCVIKSYDSPSSAVRKTAVYCLVAMVNKLGMKTMEPHLQNLSSGKLNLVQVYVNRAMSSSSHSHV", "function": "Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming. Essential for embryonic development.", "AFDB_id": "AF-P32744-F1-model_v4" }, { "swissprot_id": "C0QUE5", "sequence": "MGNFRPKKRFGQHLLISKGVIQKIVECLDIKEDDTVVEIGVGTGQLTEEILRRNPKIVYGIEIDKTVYPIIEERFKDFKNFVLIKEDFFDVDLRKLTDGKIKLTGNLPYNVASHILVNTAFYIDILQLAVFMIQKEVAQKLVGKPKTKDYTFMSVFLQTFFDIDYVMSVPARFFSPPPKVTSAVIRMIPKEKLPVSLDHMKKYKNFVSMLFSNRRKMLRSKIDKDILERAGIDPKARAEELSVDDFIRLFSEHLLYKHDGKNENS", "function": "Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.", "AFDB_id": "AF-C0QUE5-F1-model_v4" }, { "swissprot_id": "Q4WUT7", "sequence": "MGSPFLNHRLRSELGDLALLHLRRDQTIPTILKLEDDENQGYKEGKVTNTRFGSFPHSTLIDQPWGSQIVASVVDTGSRGRKNQSSKKRKADDLDTPTSNKDEAQSSPGTPRAAASGFLHLLYPTPELWTASLPHRTQVVYTPDYSYILHRLCVRPGSTIIEAGAGSGSFTHASVRAVFNGYPSEAPAAKKRRLGKVCSFEFHAQRAQRIREEIHDHGLDALVEVTHRDVYEDGFLLGDPKTGKSPKANAIFLDLPAPWLALKHLVRRPPSGAESPLDPSSPVYICTFSPCIEQVQRTITTLREYSWLSISMVEVNHHRIDVKRERTGLDCEGVRGATVFPKSVDEAVAKMRAVEEHSRRFRESLLQESDDEGTASDKPAATKSGKTEVEEKSLQDISQHSDTTAAPSSTPSYDLGRLVHRTEPDLKTHTSYLVFAILPREWTEEDEQRCRQAWPAQKTGGSPDAGKPKGKKQLKREAKEKEVQEEAQKSEDVPARPQETQS", "function": "Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.", "AFDB_id": "AF-Q4WUT7-F1-model_v4" }, { "swissprot_id": "P31007", "sequence": "MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADFIKSSNLNRNCAYEFNNDASSNQTNQSALNQNPIANNVSAQAQAEALSRTFKSELEEILNQRMRIESDTENAKEPTVEQQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDSWLYEDIQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPRAVSTEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGSGTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRKKKNFTFSRKFPFMKSRDEKNEDGSDQEPFMLCYTQDDANAEGASEENVLSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKESL", "function": "During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.", "AFDB_id": "AF-P31007-F1-model_v4" }, { "swissprot_id": "Q9I574", "sequence": "MKKALWLLLAAVPVVLVACGGSDDDKQTAQVDYLALPGDAKLDTRSVDYKCENGRKFTVQYLNKGDNSLAVVPVSDNSTLVFSNVISASGAKYAAGQYIWWTKGEEATLYGDWKGGEPTDGVACKER", "function": "Specifically inhibits C-type lysozymes.", "AFDB_id": "AF-Q9I574-F1-model_v4" }, { "swissprot_id": "P50493", "sequence": "MEGKKKRPLFFLLVLLLSHKANNVLFERMKGILLLECENEYVKNENGYKLATGHHYMDNDQIERWLQGTDRSRRVKIEENVKYKYNVEELNTKYEQTKGKRINRILKESTYEAQNVADNNYIDDKANGEYKTDNKTNKGEGARNMVMLDYDISGSGHPDGIIDNVVELGTEDEGNFLENSSKGGDHPYRMNRKERMCSGVINQTFLQKNVMRRCNNKRKRGTRDWDCPTKKDVCIPDRRYQLCMKELTNLVNNTKTHSHNDITFLKLNLKEKLTYDAAVEGDLLLKKYNNVYSEDLCKDIKWSLEDFGDIIMGTDMEGIGYSQVVENNLRTVFGTGTKTQLDRKKWWNESKKYIWEATILSVKKKLNGYSAWNCKEDVQINVEPQIYRWIREWGMDYMSELPKEQRKIKEKCDRKLYYTNLRICTMSPCNDSCKLYDQWITRKKKQWDVLSTKFSSVKKGQIIETENITTAYDILKQELNGFNEVMFENEINKRDNVYIDICLCAADEPNKNTQEHLKKLKSAPKLETQRSHSTIQPMSSSGAEKVQGDLAHGNINDAAYKSTTDEAAKGDGQNGNQTVAESNIKGTDNIENEAAKNVDTYKFVTERSADTRGATDITETGEEKLNTSYSGSSEITVKENIPGDGIVKDVSAAVENSENPLETKHKIFEPSKDNSDNSENSGSMEFKATSSNPITEAVESSSAEGQVQEDSAHRSVNTGRDNSTISAATSDDGLSSGDKRVESLTSIENADDGGDPVQGSLWNLLNDPSVGAGGGKSHIKTEENEGSQAEIDGKNVDIAEQRTATITEVQPERPDLSDTDNGNVPRSGNKQNEGATALSGAESLESNESVHKTIDNTTHGLENKNGGNEKDFQKHDFMNNDMLNDQTSSDQTSSDQTSSNQTSSDQTSSNQTSSDQTSSDQISSDQTSSDQTSSNQTSSDQTIDTEEHHRDNVRNPEIKSSEDMSKGDFMRNSNSNELYSHNNLNNRKLNIDQYEHRDVKATREKIILMSEVNKCNNRASLKYCNTIEDRMLSSTCSRERSKNLCCSISDFCLNYFELYPYEFYNCMKKEFEDSSYECFTKGSSTGIGIVYFATGGAFLIILLLFVSKNVASNDYEEEATFDEFVEYSDDIHRTPLMPNHIEHMQQFTPLDYS", "function": "Binds to the human erythrocytes Duffy blood group determinant.", "AFDB_id": "AF-P50493-F1-model_v4" }, { "swissprot_id": "B6EUA9", "sequence": "MANNPPQSSGTQFRPMVPGQQGQHFVPAASQPFHPYGHVPPNVQSQPPQYSQPIQQQQLFPVRPGQPVHITSSSQAVSVPYIQTNKILTSGSTQPQPNAPPMTGFATSGPPFSSPYTFVPSSYPQQQPTSLVQPNSQMHVAGVPPAANTWPVPVNQSTSLVSPVQQTGQQTPVAVSTDPGNLTPQSASDWQEHTSADGRKYYYNKRTKQSNWEKPLELMTPLERADASTVWKEFTTPEGKKYYYNKVTKESKWTIPEDLKLAREQAQLASEKTSLSEAGSTPLSHHAASSSDLAVSTVTSVVPSTSSALTGHSSSPIQAGLAVPVTRPPSVAPVTPTSGAISDTEATTIKGDNLSSRGADDSNDGATAQNNEAENKEMSVNGKANLSPAGDKANVEEPMVYATKQEAKAAFKSLLESVNVHSDWTWEQTLKEIVHDKRYGALRTLGERKQAFNEYLGQRKKVEAEERRRRQKKAREEFVKMLEECEELSSSLKWSKAMSLFENDQRFKAVDRPRDREDLFDNYIVELERKEREKAAEEHRQYMADYRKFLETCDYIKAGTQWRKIQDRLEDDDRCSCLEKIDRLIGFEEYILDLEKEEEELKRVEKEHVRRAERKNRDAFRTLLEEHVAAGILTAKTYWLDYCIELKDLPQYQAVASNTSGSTPKDLFEDVTEELEKQYHEDKSYVKDAMKSRKISMVSSWLFEDFKSAISEDLSTQQISDINLKLIYDDLVGRVKEKEEKEARKLQRLAEEFTNLLHTFKEITVASNWEDSKQLVEESQEYRSIGDESVSQGLFEEYITSLQEKAKEKERKRDEEKVRKEKERDEKEKRKDKDKERREKEREREKEKGKERSKREESDGETAMDVSEGHKDEKRKGKDRDRKHRRRHHNNSDEDVSSDRDDRDESKKSSRKHGNDRKKSRKHANSPESESENRHKRQKKESSRRSGNDELEDGEVGE", "function": "Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries (Probable). May be involved in pre-mRNA splicing (Probable).", "AFDB_id": "AF-B6EUA9-F1-model_v4" }, { "swissprot_id": "Q55428", "sequence": "MLCPVSHLADLRQQVPFDLALLPPQACLVGGAVRDALLGRRREYLDWDFVVPSGAIETASAIASRYRAGFVVLDKARHIARVVFAHGTVDFAQQEGMSLEQDLARRDFTVNAIAYNFQQNKLIDPMAGVGDLQRGQLKMVAAVNLADDPLRLLRAYRQAAQLQFTLDPDTRTVLRELAPRIKTVAAERVQAEFNYLLGSPRGSQWLLAAWQDGILAHWFSHANLSSLNAIGCIDLAIAAIKNQLTLVERQQFFQALGKKGIAIAKLASLVCADVKIAEGELQRLKYSRHELRSVQAILQGYPQLSCLENSPTVRQLYFFFVELGKYLPHFVLYALAHCPHNYHSFIFELLTHYLNSGDRLAHPQPLITGKDLIDKLHIKPSPLIGQLLTEINIAHIEGKISNEQEALAYAQELGKS", "function": "tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the two cytidine residues to tRNA.", "AFDB_id": "AF-Q55428-F1-model_v4" }, { "swissprot_id": "F1MAB7", "sequence": "MDAAGRGCHLLPLPAARGPARAPAASSALSPAGLCSGTASASSAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGVDPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGLHYDKEKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRAISAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVITGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGEIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV", "function": "Has no diacylglycerol kinase activity.", "AFDB_id": "AF-F1MAB7-F1-model_v4" }, { "swissprot_id": "Q92II0", "sequence": "MIKIYFIAGEVSGDFVGGRIMQHLKNNTGVQLNSPVSSFVNDAVQFVGVGGKYMEEAGSFKSLFPITSINLMGFVEILPHIFKLKKLIDKTVEDIINSKADLLITIDSPGFTYRVAKRVRKLLPKLKMIHIVAPSVWAYKEGRAVKYAKIYDCLFALLPFEPPYFTKVGLDCRYIGHPIMEQEFYSDKIALREEFKIDENERVLCVTLGSRKGEILRHLSVFVSSIEEIFKSCNNLKVIFTLANPAHEAIIKPFLEDVKFNYLFSSERLKIYAVADVALAKSGTNTLEIAASGTPMIVAYKVNLISFFIIRLLIKIKYVTLINIIADKEIIPEFIQFNCRANLISNKLQELLFNSKKAYEQVIESQKILQQLGFKSNRLQLNSESFRHDEFKGKLARCTKVREHRLSLENSLVSSDRDDAVPSYIAAAIIKQEFLEPKIKLLKEKD", "function": "Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.", "AFDB_id": "AF-Q92II0-F1-model_v4" }, { "swissprot_id": "P96335", "sequence": "MFGPFKPAPHIAELPAEKIDSTYKRLRWQVFAGIFFGYAAYYFVRANFDLAQPGLIQAGLYSKAELGVIGSAAGLAYGLSKFVMAGMSDRSNPRVFLPFGLLLSGLCMTLMGLFPWATSGIAIMWVMIFLNGWFQGMGWPPCGRTMVHWWSKSERGTIVSIWNTAHNIGGMVPGAMVLLASAIFFSTHGIEAQAKDVWQQSLYFPGIAAMIFAIPVYFVMRDTPQSCGLPSIEKWRNDYPDDYNEKTYENDLTAKEIFVTYVLKNKLLWYIAIANVFVYLIRYGVLKWSPVYLSEVKHFNIKGTAWAYTIYELAAVPGTLLCGWVSDKVFKGKRGLTGFIFMILTTAAVVAYWMNPATPEAELANYSAWYENPYQLTDFVLMTLIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGTVSASAVIGWAAQHYGWDGGFYVMIGGGVLAVLLLLIVMVEEGKHKAKLGDTYGTK", "function": "Responsible for glycerol-3-phosphate uptake.", "AFDB_id": "AF-P96335-F1-model_v4" }, { "swissprot_id": "O97374", "sequence": "MEITLPRVSLSLAVLLVIVCSVDAQNYLAFPRMGRSGYLAFPRMGRSHFKSETSADVTGCCGVGIKNEFLIGQDGKEEIRSACGARADCCEGLKEVVDQKNDGVYFSMCVPDITFAQASSVRSSEVFNKLKSLLEK", "function": "The cardioactive peptides enhance the contractions of the auricle in vitro.", "AFDB_id": "AF-O97374-F1-model_v4" }, { "swissprot_id": "Q00566", "sequence": "MVAGMLGLRKEKSEDQDLQGLKEKPLKFKKVKKDKKEDKEGKHEPLQPSAHHSAEPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPGKLLVKMPFQASPGGKGEGGGATTSAQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHAESPKAPMPLLPPPPPPEPQSSEDPISPPEPQDLSSSICKEEKMPRAGSLESDGCPKEPAKTQPMVAAAATTTTTTTTTVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS", "function": "Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).", "AFDB_id": "AF-Q00566-F1-model_v4" }, { "swissprot_id": "P36627", "sequence": "MESESVPTVPQTTRPGPRCYNCGENGHQARECTKGSICYNCNQTGHKASECTEPQQEKTCYACGTAGHLVRDCPSSPNPRQGAECYKCGRVGHIARDCRTNGQQSGGRFGGHRSNMNCYACGSYGHQARDCTMGVKCYSCGKIGHRSFECQQASDGQLCYKCNQPGHIAVNCTSPVIEA", "function": "Acts in the sexual differentiation pathway. Is required for efficient conjugation. Double-stranded DNA-binding protein.", "AFDB_id": "AF-P36627-F1-model_v4" }, { "swissprot_id": "Q5ZM33", "sequence": "MATDLSEAEPVHHKALPLLTGTQLIHTDKLSEKAEDDTMPIRRSVNSSRETPPKSKPAEGGEEVKADAEATSEESASAGEEQENETLPAAAPSEAEQPKEPENEEKGETKSSVETKKDDKDQSKEKEKKVKKTIPAWATLSASQLARAQKQTQMAATSRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELERGIIRQVKGKGASGSFVVVSNAGKTVQKARDRKKSTSVSTPEQQVKLEDILPLAFTRLCEPKEASYSLIKKYVSQYYPKLKVDIRPQLLKNALQRAVEKGQLEQITGKGASGTFQLKKSGEKPLLGGTLMEDAILSAIAAMNEPKTCSTTALKKYILENHPGTNSNFQVHLLKRTLQRCEKNGWLEQISGKGFSGTFQLCFPYYPSPDVLYPEKQQDEDSEESQEEEEEESEEEEESEEEESEEEEPPPKKRMQKRPPPKSRSRAPPMKRRESKPKPRKTPAAHQGKAKPPPKVKTPVKKAKPAAPAIKKPSGGSSSKKPTASGRKEVKPSAKGKSAMRKSLRAKK", "function": "Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity.", "AFDB_id": "AF-Q5ZM33-F1-model_v4" }, { "swissprot_id": "G0S0R2", "sequence": "MFSSLNTRPAGQSLFGANTGGGLFGQSLANQPQQQQQPLQQQQQQAAPALGQSQINQNQQLGGSLWQPGSLTAYQKPIPEQIKLIVDKWNPNHPNCAFKTYLYNKVDEHTVPLYGPGPNEDPKEWEEALQRKPAPNFIPVLCSGFPSIVARLMLQRRVITEFNNKLHQINASLDAILSRHDLDHTVRAFNARRRHAELSRRCLHLAARVQVLRNRGYALSGDEDELKQKLQQIDKTLNDPAQGSRLEELWSRLIVLRGYAEDLKDQINQAGITESDGLGEEIEAKAKKILEDYDKQLQHLKKQVEEAKKDFEEWEKQHNPAPAPAR", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP57 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.", "AFDB_id": "AF-G0S0R2-F1-model_v4" }, { "swissprot_id": "F8DYT7", "sequence": "MKKVVSSLLIILGAAMLIFAIALPTYVVPKGKVLPKDIVSTTGTDPIKGNLLDASALAEGKPVSGKENLPECRGKDKQVSCFIWKDLELQSQRFTRAQEPTDDKVVTLEAGQTLFRTDRQEPKNLVNATVDRVTLDRKTQMPVADPVSTLDVNAPALNPNGEAAIGPFTRPGIQYQFPMGTDRRSYDYFDTQALKAQPIDYVGEEEQDGEKVYKFEQTVSPVELYPRLKEQLEADGDLSKADQSTLASLRLKFPAKVWGIEGADTKSAADSKDDKKKDGDKKDEKSPEVELSRYYTVKRTLWVQPDTGVIVNGKEDIWQFYAKDQDEADKMAQPENREKEMNNPKRTALYIPGAWNDESRAAQMDKAKEGLKTLKTMGTTVPWILGPLGLLLLLVGLVMALKRRRAERHANAL", "function": "Forms water-filled channels that favor the permeation of cations.", "AFDB_id": "AF-F8DYT7-F1-model_v4" }, { "swissprot_id": "P01192", "sequence": "MPRLCGSRSGALLLTLLLQASMGVRGWCLESSQCQDLSTESNLLACIRACKPDLSAETPVFPGNGDAQPLTENPRKYVMGHFRWDRFGRRNGSSSGGGGGGGGAGQKREEEEVAAGEGPGPRGDGVAPGPRQDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDELAEAFPLEFRRELAGAPPEPARDPEAPAEGAAARAELEYGLVAEAEAAEKKDEGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIVKNAHKKGQ", "function": "Endogenous opiate.", "AFDB_id": "AF-P01192-F1-model_v4" }, { "swissprot_id": "P34384", "sequence": "MFRHVAQNLGSRNTSIQSYRLLRTRWERGYLKDLYHRRQILGADPAISRSSYPNWDYDSELYAFGHRIGAPEISEDQYIKALTNESFFQRADVEENVESAQPGAEVGTEHNAELVKRGEQNLSIWLKRYLRFHLAKAPEELIEAIDSHLLDDECLAGIASHLGIDHLVRTKEFPISQESSADAFRALAGVFSDEKVKNLVIDFIVPQLVDIDFADIYPLADPLAVVTDLLKSNGVTEIEPRVLRSAGENSAEPIYVVAIYADKLKNVGQSAGESLAIAVDMAAREALLRLWDITSEKVLFFGDRAANVPLERYSQPNFSLSQKCSPGTNTNIIDHSQPVESPDNLIEAVLRYRNVVDAEVGKSYTKRLRHKFSRGSLAKRSFRYLVKPKPYTVA", "function": "Component of the mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.", "AFDB_id": "AF-P34384-F1-model_v4" }, { "swissprot_id": "P08307", "sequence": "MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGDNDNGNNNNGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKIQNSLSTEWSPCSVTCGNGIQVRIKPGSADKPKDQLDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSFLFLN", "function": "In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.", "AFDB_id": "AF-P08307-F1-model_v4" }, { "swissprot_id": "C0H4E4", "sequence": "MENFDEVIKEYQKYLEGKEKTHKINSCKHPCCEEDNLKSVKNYFKVYHKKYIPSIIQKKKKERNEHAPPLLKDIQDKRCTNVFERLNDKQFYTGVQKTKFMELLKNNKNKSSYCYNNIKVFSTMLKKPCNYVVTPGTLGIQKYGIQTGRPKTIFLFNNEKKYDKGVYFLVKSYIKNIKSLCYEITKILQPSIGPTRKIYDQNFSLVRNVNDLINGGKYLCTSGDPPAPIRNLSLHFLT", "function": "Involved in the stabilization of microtubules. Probably by controlling microtubules stabilization, plays a role in invasion, microneme secretion and parasite growth in host erythrocytes.", "AFDB_id": "AF-C0H4E4-F1-model_v4" }, { "swissprot_id": "Q4PNI0", "sequence": "MGLMLIDWCALALVVFIGLPHGALDAAISFSMISSAKRIARLAGILLIYLLLATAFFLIWYQLPAFSLLIFLLISIIHFGMADFNASPSKLKWPHIIAHGGVVTVWLPLIQKNEVTKLFSILTNGPTPILWDILLIFFLCWSIGVCLHTYETLRSKHYNIAFELIGLIFLAWYAPPLVTFATYFCFIHSRRHFSFVWKQLQHMSSKKMMIGSAIILSCTSWLIGGGIYFFLNSKMIASEAALQTVFIGLAALTVPHMILIDFIFRPHSSRIKIKN", "function": "Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal. Exhibits the highest activity for beta-carotene, followed by beta-cryptoxanthin, beta-apo-4'-carotenal, alpha-carotene, and gamma-carotene in decreasing order, but has no activity on beta-apo-8'-carotenal, beta-apo-12'-carotenal, lutein, zeaxanthin, or lycopene, suggesting that the presence of one unsubstituted beta-ionone ring in a substrate with a molecular weight greater than C35 seems to be essential for enzyme activity.", "AFDB_id": "AF-Q4PNI0-F1-model_v4" }, { "swissprot_id": "Q9Z722", "sequence": "MLSRIVTCFLFLLSSLPLFAEEEAAQSKNTFVQPAVMLAIAILFFYFILWRPEQKRRKAMEKRKNDLAKGDKVTAMGIIGTVDDIREHTVILNIASGKVEVLKGAISEILKPNDNKS", "function": "The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.", "AFDB_id": "AF-Q9Z722-F1-model_v4" }, { "swissprot_id": "Q03162", "sequence": "MRDSNHRSLTSNKPIVTITSTVYDRRALDINSSIPLINSLNYLTYLTSNSSKVRETVANDGALERLVSILRSCHLSLFELLDLDLENFNEHENIKDLWKEKRLALCAWKWTLTFQCLVLTGTRGTEQIRKKVVMSGVLSVLVTVLDNYLLYHKNYDFIKDQTMTFDFKGITTETMYKFMRKDENETYQQYIEFITGQDKLKLSTDKNFLNERLVAPSMTIPTDFSDIWGRFADLASNFEPDQERHDDDIDIDSEVESENFDAHKNFFSQPDINRPTISTPREFFLGRIVPKQDDVIWSLQLLAFVSKYTYMKSTLQNVELVESLSFRSMAYKIKQRISEENDLEEQERDVTVKLSSLYPYLSKNPENNSKVKALDTSKMDPFFKELEELSNRCQQEEQNEICNNHCPVLNLFERYRVPKPSDDNAYGKDKERINLRKKISDNFERRWSYDKMKKELTNIVYKNKVLTNVVNIFPLVEKYTVSAENTHDVIYWSSVIMRNSCRKNEILGVRQCANFSCGKWEDFPRQFAKCRRCKRTKYCSRKCQLKAWGYHRYWCHEVGSSHMRSTNTTTGVNTPNEPSSLNATATTAADVSNSTSTFTPNISTTVPDEISNRDENSIPE", "function": "Involved in the determination of the onset of polarized growth. Required for the ubiquitin-dependent degradation of RPN4. Cooperates with UBR2 to transfer ubiquitin from RAD6 to RPN4.", "AFDB_id": "AF-Q03162-F1-model_v4" }, { "swissprot_id": "Q54RB9", "sequence": "MFANRVRQAQKLYQKRFFSLGNNSTISKQQFKNSSNNNNNKNGGNKNGFYQKAFIATTVALTTTLLTATTLLDDNTNSEKEILKSQRQTFEKYASTTLEGERQMTAEDFLSALTTLESDKQSGEHEILKASLDADKFKVLFQMADVDHTGYISFDEYVMFDELMAKPEAEYFLAFKLFDRDGNGYISKNDFKHVITASLDPSIPFNFDCELVNLYFGDGRTELNYSQFTQLLKDLQQERIKQEFKFHDKYNSGYIPRDKFAKVLGSVKLRKIPDHVRDKLESISELNLLSGHPNEVSYSQFVAANDMLLHIPSYGRVLKAAILKNKKDNINKEEFLTEARSSTSIEITPLEIDLIFHLFDLNKDGKLSISDFEKSTGLNINKIGGGTNYSDSYPSDSHVTIQNSSTTPSPSTPITNTAAAIALNKKHGKTFAQQVLESIENFALGSIAGGIGAAAVYPIDLVKTRMQNQRAVDPAKRLYVNSWDCFKKVVKFEGVRGLYKGILPQMVGVAPEKAIKLTVNDLLRDLFGDKSKGEIYFPLEVLAGGFAGMSQVCVTNPLEIVKIRLQVQSTGPKVSAITIIKELGLAGLYKGAGACLLRDIPFSAIYFPTYAKMKTILANEDGKLGPMDLLLAGAVAGIPAASLVTPADVIKTRLQVKANAGEQTYTGIRDCFQKILKEEGPRALFKGALARVFRSSPQFGVTLVSYELLQKALLPDAEYKPPTNAPITQKDFDVIRGNTNTVQRVIDMESKFGTLHQTRDNNKSSNGGENKN", "function": "Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.", "AFDB_id": "AF-Q54RB9-F1-model_v4" }, { "swissprot_id": "P23654", "sequence": "MGELEEKETPPTETTAAQQEALEEPKETDKMLDKKEDAKEKTPSPQTSKPASPNAGKKSSPVAEKKIDDAELAKSKSGNGEEIIDIPAENGTKPDSADDKKISKEEREVKPKKIPIGGLKLPGFFMKNKPKADGDGAEGELLEKEKEEDKDKEANGDAATGSGKDEQKSRPGLGERLRSFFARKPSAEKEKKQLVNGDADAKSEATAEATPAEDASDAPPKRGLLNAIKLPIANMIPKKKSNDDVELGLGKAGLASMETLDDSLKDQDTVDRAPVKTNGTEELKGELKDEKLAAEEKLAAEEEEQNRPVSLLTRLRGYKCSVDDALIVFGILLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGDEDCLYLDVVTPHVRYNNPLPVVVLIGAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLECADIQCLREASSERLWAATPDTWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYWISKDIVPRYARVD", "function": "May mediate or modulate cell adhesion between embryonic cells during development.", "AFDB_id": "AF-P23654-F1-model_v4" }, { "swissprot_id": "Q9LZA5", "sequence": "MVLRLRVHSFYNRGISFLVSSSLRNLSTASSLFLNSDQTITEPLVKSELEALVLKQYSHGKFYSLVKNAVSLPCVLLAACQNLSLSANSSGDLADRVSRRFSIEEMGREIREGRFDIRSCCVEFISSSLVLPNLKLKVLIEAIRMVLEIVYDDRFATFSYGGRVGMGRHTAIRYLKNSVENPRWWFRVSFAREMFEERNVDILCGFVGEKINDVMLIEMIKKLFEFGILKIELGGCNSGRGFPQECGLCSILINVYFDGLDKEIQDLRLKMKVKNPRVGTGDEESTGNVFFKPVNIYAVRYLDEILVITSGSKMLTMDLKKRIVDILEQRLELRVDRLNTSIHSAVSEKINFLGMYLQAVPPSVLRPPKSEKAVRAMKKYQRQKDVRKLELRNARERNRKTLGLKIFRHVLKKIKQSNGFKFEGEIENEVRDIFQSWGEEVMQDFMGSLEERWKWHWLLTRGDFLSLRHIREKLPQDLIDAYDEFQEQVDKHLAPTQAKKVLEDEERRVEEEEEQRYAERTVEDLTKLCMKVSAPEELVRKAIKLVGFTNSMGRPRPIIHLVTLEDSDIIKWYARHEKHGSTKKLIRHYTKDLRVSDLDGREEAHFPSEREVKMMGDKNLSDPKPVDGTLSLLLIRLASDEPLHHCAASFCERSDTIMHRVHLLQNRLHINPLDEEKWVPGMGTIHSALNRKCLPLCSTHISDVYLGKITLQDVDSSSFIDLR", "function": "Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Necessary for mitochondrial biogenesis during early developmental stages.", "AFDB_id": "AF-Q9LZA5-F1-model_v4" }, { "swissprot_id": "O51713", "sequence": "MNKLMLMLITFATSLLAQTNKASTGLKTDQSFNNSLSESVKLKEIADIYPTNTNFLTGIGIVAGLAGKGDSIKQKDLIIKILEENNIINEIGSNNIESKNIALVNVSLQVKGNTIKGSKHKACVASILDSKDLTNGILLKTNLKNKEGEIIAIASGITQPNNKLKGSGYTIDSVIINENQNINHSYNIILKKGNYTLINRIHKILTSKKINNKIKSDSTIEIEAKNISLLEEIENIKIETNPKILIDKKNGIILASENAKIGTFTFSIEKDNQNIFLSKNNKTTIQVNSMKLNEFILKNSNNLSNKELIQIIQAAQKINKLNGELILEEIDGNQN", "function": "Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.", "AFDB_id": "AF-O51713-F1-model_v4" }, { "swissprot_id": "O94769", "sequence": "MKIAVLFCFFLLIIFQTDFGKNEEIPRKQRRKIYHRRLRKSSTSHKHRSNRQLGIQQTTVFTPVARLPIVNFDYSMEEKFESFSSFPGVESSYNVLPGKKGHCLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQTVIPEGECCPVCSATVSYSLLSGIALNDRNEFSGDSSEQREPTNLLHKQLPPPQVGMDRIVRKEALQSEEDEEVKEEDTEQKRETPESRNQGQLYSEGDSRGGDRKQRPGEERRLAHQQQRQGREEEEDEEEEGEEGEEDEEDEEDPVRGDMFRMPSRSPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNIK", "function": "Promotes matrix assembly and cell adhesiveness.", "AFDB_id": "AF-O94769-F1-model_v4" }, { "swissprot_id": "Q03096", "sequence": "MPKVILESHSKPTDSVFLQPWIKALIEDNSEHDQYHPSGHVIPSLTKQDLALPHMSPTILTNPCHFAKITKFYNVCDYKVYASIRDSSHQILVEFSQECVSNFERTHNCRITSETTNCLMIIGDADLVYVTNSRAMSHFKICLSNISSKEIVPVLNVNQATIFDIDQVGSLSTFPFVYKYL", "function": "Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.", "AFDB_id": "AF-Q03096-F1-model_v4" }, { "swissprot_id": "Q6LFW5", "sequence": "MRVLYITANPKLIHHSVSLSLGELALQYYRELNPSHITDRLDLTTEEYPHLNSDTLSNFMNPHSNLATQSKIFKDYDKYIIVAPMWNLTVPSALKAYLDTVIIPNVLFRYTEQGTCEGLCGGKMIYIGARGGDYSHPPQSEYAFDDKYMEGIAKMIGLESYQSYVANAVGGYRRRSVAQWVEHAKYDIEQMVTSF", "function": "Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.", "AFDB_id": "AF-Q6LFW5-F1-model_v4" }, { "swissprot_id": "O67115", "sequence": "MRIVSGMRPTGKLHLGHYFGVIRNWVKLQEEHECFFFIADWHALTTAYKNTKELRQNIREVMIDWLALGLDPQKSVLFIQSLVKEHAELFLLFGMITPKSWLELNPTYKDLKYNLLRLTDLEKEFKEKLKERISEIVNLIPFNITKEEKFREHLLENLTQTMIEALFEGEIEPEILKRLNVSKRDFYETDTFGFLGYPVLQAADILIYKGEGVPVGEDQLPHIELSREIARRFNRLYGKIFPEPKALLTETPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKKVMKMFTDPQKIRKNDPGRPEICPVFSWHKLFTKDEELVKKIEEDCRAGRLGCVECKRILLKHLEEFLEPIRERRRELEKRINEIEEVFYENSRKAREIAQKTMEEVRKAMNLP", "function": "Catalyzes the attachment of tryptophan to tRNA(Trp).", "AFDB_id": "AF-O67115-F1-model_v4" }, { "swissprot_id": "P45798", "sequence": "MCTMPLMKLKKMMRRTAFLLSVLIGCSMLGSDRSDKAPHWELVWSDEFDYSGLPDPEKWDYDVGGHGWGNQELQYYTRARIENARVGGGVLIIEARHEPYEGREYTSARLVTRGKASWTYGRFEIRARLPSGRGTWPAIWMLPDRQTYGSAYWPDNGEIDIMEHVGFNPDVVHGTVHTKAYNHLLGTQRGGSIRVPTARTDFHVYAIEWTPEEIRWFVDDSLYYRFPNERLTDPEADWRHWPFDQPFHLIMNIAVGGAWGGQQGVDPEAFPAQLVVDYVRVYRWVE", "function": "Shows activity on lichenan, beta-glucan and laminarin but not on CMC cellulose or xylan.", "AFDB_id": "AF-P45798-F1-model_v4" }, { "swissprot_id": "O74529", "sequence": "MPEDYWSAKDYQRNASFVPKLTKDIVKRINLSSSDELLDLGCGDGVLTNELVSQCRRVVGIDASPDMIKAARELGLNAYVIPGEKLLDASEIPSESFDVVFSNAALHWIMRQPKNRPIVMKGVSRVLRTKGRFVAECGAFGNVSEVVGSIYSILLALGATKEQIDQANPWFFGSEDDYTRMLEEAGFHVEYVENISRPTLLNKDVREWLDTFAQHFYHAFPQWKDIIRETVYNALLVTDCRSDGKWFLQYRRLRFVAHKE", "function": "Probable methyltransferase.", "AFDB_id": "AF-O74529-F1-model_v4" }, { "swissprot_id": "A0B5I5", "sequence": "MLRPVHCVVPFKSSGCKTRLSSALSGEQRWQLAVAMLRDVLRTLRSIGMVTVLARPGMREDIIADLDATLRFSELELGDALNGFIDENTAAGWPADILIVMADLPLIREEDVLEMIRTPGGVVLAPGRGGGTNMILIRDSRFRTRYKGLSFAKHKREAEELGIEAGYCYSYRAGCDIDEPGDLIEILLHTNGESRALLERFGLRILESDGRGRLDQTQSNE", "function": "Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.", "AFDB_id": "AF-A0B5I5-F1-model_v4" }, { "swissprot_id": "O74846", "sequence": "MTAAASDDAVYNKVADILRQCEDFHRLSTHIERFEREQASLNMHVKTELEKHVEAVELGKLALHDAQTKRVKLLQELHNMLTLCESAREMVDEFPLISRMSRIYKNCYATKQMISQLNNLVKETDVIEDMLREDLELDSDMPNLLRAHYKLSKLREFREEALYQASLEGQSDLPITLENSFSNLNTLSDNFDRLVLNFCRNIFQLVKSGHIKTIVQIFKIVEAEESSDEVLKSIRDAKSSLPDSQDGPFLSLQGMTRQLRNFRLRVLEEFQGAAAENFQRAWVSYLEDGSGELNLDFIFEDLKVAFYVLPDLTPPSYNIAKTFASIYQECLVGLVTKAVSLDTPAAVYLYLINFHREYRKFFEENAPFSVDEVEPGLEDGKDGILVREYTRLFTQKIREWSDKLFQSSVDTFMKRESEPELDSDGNYGLQGTIIFFQMITQQINIISHTNNSDVVGIVLSSIMYIMQSMQDQWKSVMRSELSQQLSGNPESVPPGLMEYLLAVANDNLKCAGFMDNTLLNTFELITSEREEDLREAFGKTVDGYILISDIGVSQIVAIISNDVKPALTSLFQPNWYQSSNMKLIVDTFRDYIVDCIEHMVPGLFDVFLLEASNALTISYLRSIFNKNACFDGDNAIQQIRSDIALAIRVFGEYMAAEHLRSTFEPIEKLLLGMLDADVETVSEYFHLLKEAYWDAPLSLVEAVLQNRTDLEKSIIKKMIDIVRHENDSLQIDTSQQPTVFSQVTSLSGSSIL", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.", "AFDB_id": "AF-O74846-F1-model_v4" }, { "swissprot_id": "Q0P8I7", "sequence": "MSKKVLITGGAGYIGSVLTPILLEKGYEVCVIDNLMFDQISLLSCFHNKNFTFINGDAMDENLIRQEVAKADIIIPLAALVGAPLCKRNPKLAKMINYEAVKMISDFASPSQIFIYPNTNSGYGIGEKDAMCTEESPLRPISEYGIDKVHAEQYLLDKGNCVTFRLATVFGISPRMRLDLLVNDFTYRAYRDKFIVLFEEHFRRNYIHVRDVVKGFIHGIENYDKMKGQAYNMGLSSANLTKRQLAETIKKYIPDFYIHSANIGEDPDKRDYLVSNTKLEATGWKPDNTLEDGIKELLRAFKMMKVNRFANFN", "function": "NAD-dependent dehydrogenase involved in the biosynthesis of heptose moieties with a hydroxyl group at C6 found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the initial oxidation of C4 of the GDP-D-glycero-alpha-D-manno-heptose to form GDP-D-glycero-4-keto-alpha-D-lyxo-heptose in the presence of alpha-ketoglutarate required to recycle the NADH nucleotide.", "AFDB_id": "AF-Q0P8I7-F1-model_v4" }, { "swissprot_id": "O42904", "sequence": "MSLADELLADLDDIEETTESTITDELGPDAKKRRLELQLEEGNGISAELENDLDITKISDSAQKLPSEVANKFNDNNENIYQLLNSTRLRDIIEGTEKYKGTEKQAITGNIEDDLEYHLIVDSNSIAMEIDDEILRLHRLVKEWYHDRFPELSSLVLNAFDYCKTVSSLLNDLDNSKTKLSFLPSATVMVIATTATTTVGKPLPDEMIKNVKNCCEAIQQLGEEKQKIIEYVQSRISVVAPNLSAVVGSTTAANLIGIAGGLTRLGKFPACNLPALGKRRLTTIGINNPAVSGDYGFLYMSEIVQKTPPDVRKQAIRMTAAKVALAARIDSIHEYPDGSFGISARKEVERKIEKLLEPPSQKPTVALPVPDDRPKRRRGGRRIRKMKEQYAVTELRRLQNRVAFGKEEAEVFNFDETEGLGMLGQEGEGKIRAVSIDSRTKLRLPKARKAQLQSMAQKNPLAASGLQSSLSFTPIQGIELVNPLLQRQQKVEEANKWFRDGVFTQIKKDSNEPKNKFS", "function": "Required for spliceosome assembly where it is needed to link the U4/U6XU5 tri-snRNP to the prespliceosome complexes.", "AFDB_id": "AF-O42904-F1-model_v4" }, { "swissprot_id": "Q63003", "sequence": "MFLEVADLKDGLWVWKVVFLQVCIEASGWGAEVRDSCGCGDSSSHQTDDPATALALHVACHSFKGQLVQQTLLLGTRPRVWVNNIPQEGPSLPLRQWLLPQCPSLNRSGSAMGTGWGLSGLSPTALSRDGYETETPFSPEGAFPGGGPAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGSQEKPTFVVQVSTEQLLMSTGGCDKEPPRGQGVDTRGDRTQEGGEKPREQREGPRPEQGPDIPGQQEESPQQEPSSERGDSVGEREARSPGHEGEGGGEWPGISGERRESPGEWGADVPRGRGEGAGEWGSDVPKDRGEGGREWGPEAAQEHGEAARDWTSESPRTLGEDARDWGSSSRDAAGSSPCALRGSLAPERLGDGPWPAWPSPQEREPGPRDRVESPREWGGTESPRGWEAGPREWGPSPGGRGDGPRRRPRKRRGRKGRMGRQLETTATSASATGGPAEEAGASAPEGQAGGGPRGRARGPRQQARRRHGPQRRRGPPQAGEEGPGDATLVLGLGTTSGEQRADQSQTLPALAGAPTAHAHAVPGPGPAAATLGGRGRRGSWRGGRRGGGAGASGGGRGGRGRGRGGRRGSGLSGTREDAGSPSARRGEQRRRGHGPPAAGAAQVSTRGRRARGQRTGEEAQDGLLPRGRDRLPLRPGDSNQRVERPGHPRGGHGAINAPSAPDASPPHHPRRWVSQQRQRLWRQFRVGGGFPPPPPTRPPPVLLPLLRLTCAGDPGASRPGSRRPARRPRGELTPQRPSPFAPQEEGLRAESCVDDGAIAPDTDTASGEVPEAGPSLSSTMCQMGRPRPSPKSPR", "function": "Might have DNA-binding ability.", "AFDB_id": "AF-Q63003-F1-model_v4" }, { "swissprot_id": "Q9I6Z0", "sequence": "MSRTWIRNPLAIFTANGLDAAGGLVVEDGRIVELLGAGQQPAQPCASQFDASRHVVLPGLVNTHHHFYQTLTRAWAPVVNQPLFPWLKTLYPVWARLTPEKLELATKVALAELLLSGCTTAADHHYLFPGGLEQAIDVQAGVVEELGMRAMLTRGSMSLGEKDGGLPPQQTVQEAETILADSERLIARYHQRGDGARVQIALAPCSPFSVTPEIMRASAEVAARHDVRLHTHLAETLDEEDFCLQRFGLRTVDYLDSVGWLGPRTWLAHGIHFNAEEIRRLGEAGTGICHCPSSNMRLASGICPTVELEAAGAPIGLGVDGSASNDASNMILEARQALYLQRLRYGAERITPELALGWATRGSARLLGRSDIGELAPGKQADLALFKLDELRFSGSHDPLSALLLCAADRADRVMVGGAWRVVDGAVEGLDLAALIARHRAAASALIAG", "function": "Specifically deaminates 8-Oxoguanine (8-oxoG) to uric acid. 8-oxoG is formed via the oxidation of guanine within DNA by reactive oxygen species and leads, if uncorrected, to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.", "AFDB_id": "AF-Q9I6Z0-F1-model_v4" }, { "swissprot_id": "Q08303", "sequence": "MASLCSNSSSTSLKTPFTSSTTCLSSTPTASQLFLHGKRNKTFKVSCKVTNTNGNQDETNSVDRRNVLLGLGGLYGVANAIPLAASAAPTPPPDLSSCNKPKINATTEVPYFCCAPKPDDMSKVPYYKFPSVTKLRIRPPAHALDEAYIAKYNLAISRMKDLDKTQPDNPIGFKQQANIHCAYCNGGYSIDGKVLQVHNSWLFFPFHRWYLYFYERILGSLIDDPTFGLPFWNWDHPKGMRFPPMFDVPGTALYDERRGDQIHNGNGIDLGYFGDQVETTQLQLMTNNLTLMYRQLVTNSPCPLMSLVDLTLFGSTVEDAGTVENIPHSPVHIWVGTRRGSVLPVGKISNGEDMGNFYSAGLDPLFYCHHSNVDRMWNEWKATGGKRTDIQNKDWLNSEFFFYDENGNPFKVRVRDCLDTKKMGYDYHATATPWRNFKPKTKASAGKVNTGSIPPESQVFPLAKLDKAISFSINRPASSRTQQEKNAQEEVLTFNAIKYDNRDYIRFDVFLNVDNNVNANELDKAEFAGSYTSLPHVHRVGDPKHTATATLRLAITELLEDIGLEDEDTIAVTLVPKKGDISIGGVEIKLAIVKLVCVVNLLTLQLNKDRFCYDSVFVCWFVCLFFNFHV", "function": "Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.", "AFDB_id": "AF-Q08303-F1-model_v4" }, { "swissprot_id": "Q43675", "sequence": "MEFAHLTVLSLFCLAFVGITATSSGEDYWQSIWPNTPLPKTFSDLLIPSGITNSLPIKSEELKQYSTLFFEHDLHPGKNFNLGHTNSVGSIIRPFTKSRQGVTDSIWLANKEKQSLEDFCYSPTAIAEHKHCVSSLKSMIDQVISHFGSTKIKAISSNFAPYQDQYVVEDVKKVGDNAVMCHRLNFEKVVFNCHQVRDTTAYVVSLVASDGTKTKALTVCHHDTRGMNPELLYEALEVTPGTVPVCHFIGNKAAAWVPNHTADNLCVM", "function": "Associated with the protein storage vacuole formation.", "AFDB_id": "AF-Q43675-F1-model_v4" }, { "swissprot_id": "Q7UNW7", "sequence": "MSWDYRPLLSGQSRDPFSSMARGALWCASGFYNVAARHRRRQYDSGNREICNAGVPVISVGNLTTGGTGKTPVVADLCRRLRAMDFRVTIISRGYGASDGRMNDEAMELQERLPDVPHVQHPDRVEAARIAVEELAAEVLVMDDGFQHRRLQRDLDIVVIDATCPFGYGHVLPRGTLREPLDSVTRADWVLITRVDQVDPEEVLAIRSTIAQHAPDCPVLETEHRPSTIQSSVGDWEAIEVLIDQPVALVSAIGNPDAFEQTVLDCGAIVVDHLRLPDHDSYERATREKLRSWVTKLKGGPQPPQRLLCTHKDAVKLATDSIAGVPLGYMPIELAYRTSEEPLQLRLELLMGGSVENQSSRDDSA", "function": "Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).", "AFDB_id": "AF-Q7UNW7-F1-model_v4" }, { "swissprot_id": "P39702", "sequence": "MEQNGLDHDSRSSIDTTINDTQKTFLEFRSYTQLSEKLASSSSYTAPPLNEDGPKGVASAVSQGSESVVSWTTLTHVYSILGAYGGPTCLYPTATYFLMGTSKGCVLIFNYNEHLQTILVPTLSEDPSIHSIRSPVKSIVICSDGTHVAASYETGNICIWNLNVGYRVKPTSEPTNGMTPTPALPAVLHIDDHVNKEITGLDFFGARHTALIVSDRTGKVSLYNGYRRGFWQLVYNSKKILDVNSSKEKLIRSKLSPLISREKISTNLLSVLTTTHFALILLSPHVSLMFQETVEPSVQNSLVVNSSISWTQNCSRVAYSVNNKISVISISSSDFNVQSASHSPEFAESILSIQWIDQLLLGVLTISHQFLVLHPQHDFKILLRLDFLIHDLMIPPNKYFVISRRSFYLLTNYSFKIGKFVSWSDITLRHILKGDYLGALEFIESLLQPYCPLANLLKLDNNTEERTKQLMEPFYNLSLAALRFLIKKDNADYNRVYQLLMVVVRVLQQSSKKLDSIPSLDVFLEQGLEFFELKDNAVYFEVVANIVAQGSVTSISPVLFRSIIDYYAKEENLKVIEDLIIMLNPTTLDVDLAVKLCQKYNLFDLLIYIWNKIFDDYQTPVVDLIYRISNQSEKCVIFNGPQVPPETTIFDYVTYILTGRQYPQNLSISPSDKCSKIQRELSAFIFSGFSIKWPSNSNHKLYICENPEEEPAFPYFHLLLKSNPSRFLAMLNEVFEASLFNDDNDMVASVGEAELVSRQYVIDLLLDAMKDTGNSDNIRVLVAIFIATSISKYPQFIKVSNQALDCVVNTICSSRVQGIYEISQIALESLLPYYHSRTTENFILELKEKNFNKVLFHIYKSENKYASALSLILETKDIEKEYNTDIVSITDYILKKCPPGSLECGKVTEVIETNFDLLLSRIGIEKCVTIFSDFDYNLHQEILEVKNEETQQKYLDKLFSTPNINNKVDKRLRNLHIELNCKYKSKREMILWLNGTVLSNAESLQILDLLNQDSNFEAAAIIHERLESFNLAVRDLLSFIEQCLNEGKTNISTLLESLRRAFDDCNSAGTEKKSCWILLITFLITLYGKYPSHDERKDLCNKLLQEAFLGLVRSKSSSQKDSGGEFWEIMSSVLEHQDVILMKVQDLKQLLLNVFNTYKLERSLSELIQKIIEDSSQDLVQQYRKFLSEGWSIHTDDCEICGKKIWGAGLDPLLFLAWENVQRHQDMISVDLKTPLVIFKCHHGFHQTCLENLAQKPDEYSCLICQTESNPKIV", "function": "Required for localization and recycling of the CPY sorting receptor (VPS10) to the late-Golgi compartment. Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process.", "AFDB_id": "AF-P39702-F1-model_v4" }, { "swissprot_id": "A1B198", "sequence": "MKIAEIHVYAHDLPVKDGPYTIASSTVWSLQTTLVKIVADSGLAGWGETCPVGPTYAPSHALGARAALAEMAPGLIGANPLQPLVLRRRMDGLLCGHNYAKAAIDIAAYDLMGKHYGVRVADLLGGVAAERVPSYYATGIGQPDEIARIAAEKVAEGFPRLQIKIGGRPVEIDIETVRKVWERIRGTGTRLAVDGNRSLPSRDALRLSRECPEIPFVLEQPCNTLEEIAAIRGRVQHGIYLDESGEDLSTVIRAAGQGLCDGFGMKLTRIGGLQQMAAFRDICEARALPHSCDDAWGGDIIAAACTHIGATVQPRLNEGVWVAQPYIAQPYDEENGIRIAGGHIDLPKGPGLGITPDESLFGPPVASFS", "function": "Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.", "AFDB_id": "AF-A1B198-F1-model_v4" }, { "swissprot_id": "Q51973", "sequence": "MGEDISKIVIIGAGQAGATVAFGLRRNGFAGEITLVGEESHLPYERPQLSKEMLRPEASAHKSIKTRADYEEQSILLELGCKVVRADAQAHSIVLDDGRQLAFDRLVIATGVQPRRLSSAFQGAHRVHYLRTLEDAARLRADLEAGKSLAIVGGGVIGLEVAAAARALNCPVTLIEAADRLMSRSVDEVVSAYLDRAHRRNGVDIRYGVAATELLDDGRLRLSDGGTVPAEAVLVGIGVTPNIEGFEHLDITDATGVRVDAYSQTVVPGIFATGDIASQPNGGGFGRIETWANAQDHALNLVKNLMGEAVPYEAPVWFWSDQGPINLQVVGDAANGRRIVRGDEHGDVFSVFRLDANQQVIGCATVNSPKDMAVARRWVKQRSSVDPQRLADPTIPLRDCAV", "function": "Component of the p-cumate 2,3-dioxygenase multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into p-cumate to form cis-2,3-dihydroxy-2,3-dihydro-p-cumate. Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (CmtAd).", "AFDB_id": "AF-Q51973-F1-model_v4" }, { "swissprot_id": "Q04681", "sequence": "MKLSKIALAAALVFGINSVATAENETPAPKVSSTKGEIQLKGEIVNSACGLAASSSPVIVDFSEIPTSALANLQKAGNIKKDIELQDCDTTVAKTATVSYTPSVVNAVNKDLASFVSGNASGAGIGLMDAGSKAVKWNTATTPVQLINGVSKIPFVAYVQAESADAKVTPGEFQAVINFQVDYQ", "function": "Major structural component of PMF fimbriae.", "AFDB_id": "AF-Q04681-F1-model_v4" }, { "swissprot_id": "Q6QLQ9", "sequence": "MKILCLLFAVLLFLFQAAPGSADPLFPDTVACRTQGNFCRAGACPPTFTISGQCHGGLLNCCAKIPAQ", "function": "Has bactericidal activity.", "AFDB_id": "AF-Q6QLQ9-F1-model_v4" }, { "swissprot_id": "O95905", "sequence": "MEETMKLATMEDTVEYCLFLIPDESRDSDKHKEILQKYIERIITRFAPMLVPYIWQNQPFNLKYKPGKGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEFPELVARIEDNDGEFLLIEAADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWLPTTPPTIPQALNIITAHSEKILASESIRAAVNRRIRGYPEKIQASLHRAHCFLPAGIVAVLKQRPRLVAAAVQAFYLRDPIDLRACRVFKTFLPETRIMTSVTFTKCLYAQLVQQRFVPDRRSGYRLPPPSDPQYRAHELGMKLAHGFEILCSKCSPHFSDCKKSLVTASPLWASFLESLKKNDYFKGLIEGSAQYRERLEMAENYFQLSVDWPESSLAMSPGEEILTLLQTIPFDIEDLKKEAANLPPEDDDQWLDLSPDQLDQLLQEAVGKKESESVSKEEKEQNYDLTEVSESMKAFISKVSTHKGAELPREPSEAPITFDADSFLNYFDKILGPRPNESDSDDLDDEDFECLDSDDDLDFETHEPGEEASLKGTLDNLKSYMAQMDQELAHTCISKSFTTRNQVEPVSQTTDNNSDEEDSGTGESVMAPVDVDLNLVSNILESYSSQAGLAGPASNLLQSMGVQLPDNTDHRPTSKPTKN", "function": "Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.", "AFDB_id": "AF-O95905-F1-model_v4" }, { "swissprot_id": "Q9M658", "sequence": "MKKDEKIGLTGRTIYTRSLAASIPASVEQETPGLRRSSRGTPSTKVITPASATRKSERLAPSPASVSKKSGGIVKNSTPSSLRRSNRGKTEVSLQSSKGSDNSIRKGDTSPDIEQRKDSVEESTDKIKPIMSARSYRALFRGKLKESEALVDASPNEEELVVVGCSRRIPAGNDDVQGKTDCPPPADAGSKRLPVDETSLDKGTDFPLKSVTETEKIVLDASPIVETGDDSVIGSPSENLETQKLQDGKTDCSPPANAESKTLPVGETSLEKEYPQKFQDDNTDCLPPANAESKRLPVGETSLEKDTDFPLKSTTETGKMVLYASPIVETRDDSVICSPSTNLETQKLLVSKTGLETDIVLPLKRKRDTAEIELDACATVANGDDHVMSSDGVIPSPSGCKNDNRPEMCNTCKKRQKVNGDCQNRSVCSCIVQPVEESDNVTQDMKETGPVTSREYEENGQIQHGKSSDPKFYSSVYPEYWVPVQLSDVQLEQYCQTLFSKSLSLSSLSKIDLGALEETLNSVRKTCDHPYVMDASLKQLLTKNLELHEILDVEIKASGKLHLLDKMLTHIKKNGLKAVVFYQATQTPEGLLLGNILEDFVGQRFGPKSYEHGIYSSKKNSAINNFNKESQCCVLLLETRACSQTIKLLRADAFILFGSSLNPSHDVKHVEKIKIESCSERTKIFRLYSVCTVEEKALILARQNKRQNKAVENLNRSLTHALLMWGASYLFDKLDHFHSSETPDSGVSFEQSIMDGVIHEFSSILSSKGGEENEVKLCLLLEAKHAQGTYSSDSTLFGEDHIKLSDEESPNIFWSKLLGGKNPMWKYPSDTPQRNRKRVQYFEGSEASPKTGDGGNAKKRKKASDDVTDPRVTDPPVDDDERKASGKDHMGALESPKVITLQSSCKSSGTDGTLDGNDAFGLYSMGSHISGIPEDMLASQDWGKIPDESQRRLHTVLKPKMAKLCQVLHLSDACTSMVGNFLEYVIENHRIYEEPATTFQAFQIALSWIAALLVKQILSHKESLVRANSELAFKCSRVEVDYIYSILSCMKSLFLEHTQGLQFDCFGTNSKQSVVSTKLVNESLSGATVRDEKINTKSMRNSSEDEECMTEKRCSHYSTATRDIEKTISGIKKKYKKQVQKLVQEHEEKKMELLNMYADKKQKLETSKSVEAAVIRITCSRTSTQVGDLKLLDHNYERKFDEIKSEKNECLKSLEQMHDVAKKKLAEDEACWINRIKSWAAKLKVCVPIQSGNNKHFSGSSNISQNAPDVQICNNANVEATYADTNCMASKVNQVPEAENTLGTMSGGSTQQVHEMVDVRNDETMDVSALSREQLTKSQSNEHASITVPEILIPADCQEEFAALNVHLSEDQNCDRITSAASDEDVSSRVPEVSQSLENLSASPEFSLNREEALVTTENRRTSHVGFDTDNILDQQNREDCSLDQEIPDELAMPVQHLASVVETRGAAESDQYGQDICPMPSSLAGKQPDPAANTESENLEEAIEPQSAGSETVETTDFAASHQGDQVTCPLLSSPTGNQPAPEANIEGQNINTSAEPHVAGPDAVESGDYAVIDQETMGAQDACSLPSGSVGTQSDLGANIEGQNVTTVAQLPTDGSDAVVTGGSPVSDQCAQDASPMPLSSPGNHPDTAVNIEGLDNTSVAEPHISGSDACEMEISEPGPQVERSTFANLFHEGGVEHSAGVTALVPSLLNNGTEQIAVQPVPQIPFPVFNDPFLHELEKLRRESENSKKTFEEKKSILKAELERKMAEVQAEFRRKFHEVEAEHNTRTTKIEKDKNLVIMNKLLANAFLSKCTDKKVSPSGAPRGKIQQLAQRAAQVSALRNYIAPQQLQASSFPAPALVSAPLQLQQSSFPAPGPAPLQPQASSFPSSVSRPSALLLNFAVCPMPQPRQPLISNIAPTPSVTPATNPGLRSPAPHLNSYRPSSSTPVATATPTSSVPPQALTYSAVSIQQQQEQQPQQSLSSGLQSNNEVVCLSDDE", "function": "Required for the heritable maintenance of transcriptional gene silencing (TGS) in heterochromatin, and particularly in the intermediate bivalent heterochromatin, characterized by an unsual methylation pattern consisting in hypermethylated DNA and histone H3 'Lys-4' methylation (H3K4me) together with depletion of histone H3 'Lys-9' methylation (H3K9me), in a chromatin methylation-independent manner, in a non-CG methylation context. May play a role in the RNA polymerase IV/V (Pol-IV/V)-mediated RNA-directed DNA methylation (RdDM) leading to TGS (also called siRNA-mediated TGS pathway), probably by modulating small interfering RNA (siRNA) accumulation. Especially involved in the gene silencing of the transcriptionally silent information region (TSI), 5S ribosomal RNA genes (localized in the pericentromeric heterochromatin of chromosomes 3, 4, and 5) and of 180-bp satellite repeats and 106B long terminal repeat (LTR)-like repeats of the chromocenters. Prevents the aberrant mRNA transcriptional read-through.", "AFDB_id": "AF-Q9M658-F1-model_v4" }, { "swissprot_id": "P81418", "sequence": "MAKVSSAYLKFALVMILLLSVISAVMSAGCIKNGGRCNASAGPPYCCSSYCFQIAGQSYGVCKNR", "function": "Possesses antifungal activity.", "AFDB_id": "AF-P81418-F1-model_v4" }, { "swissprot_id": "P08394", "sequence": "MSDVAETLDPLRLPLQGERLIEASAGTGKTFTIAALYLRLLLGLGGSAAFPRPLTVEELLVVTFTEAATAELRGRIRSNIHELRIACLRETTDNPLYERLLEEIDDKAQAAQWLLLAERQMDEAAVFTIHGFCQRMLNLNAFESGMLFEQQLIEDESLLRYQACADFWRRHCYPLPREIAQVVFETWKGPQALLRDINRYLQGEAPVIKAPPPDDETLASRHAQIVARIDTVKQQWRDAVGELDALIESSGIDRRKFNRSNQAKWIDKISAWAEEETNSYQLPESLEKFSQRFLEDRTKAGGETPRHPLFEAIDQLLAEPLSIRDLVITRALAEIRETVAREKRRRGELGFDDMLSRLDSALRSESGEVLAAAIRTRFPVAMIDEFQDTDPQQYRIFRRIWHHQPETALLLIGDPKQAIYAFRGADIFTYMKARSEVHAHYTLDTNWRSAPGMVNSVNKLFSQTDDAFMFREIPFIPVKSAGKNQALRFVFKGETQPAMKMWLMEGESCGVGDYQSTMAQVCAAQIRDWLQAGQRGEALLMNGDDARPVRASDISVLVRSRQEAAQVRDALTLLEIPSVYLSNRDSVFETLEAQEMLWLLQAVMTPERENTLRSALATSMMGLNALDIETLNNDEHAWDVVVEEFDGYRQIWRKRGVMPMLRALMSARNIAENLLATAGGERRLTDILHISELLQEAGTQLESEHALVRWLSQHILEPDSNASSQQMRLESDKHLVQIVTIHKSKGLEYPLVWLPFITNFRVQEQAFYHDRHSFEAVLDLNAAPESVDLAEAERLAEDLRLLYVALTRSVWHCSLGVAPLVRRRGDKKGDTDVHQSALGRLLQKGEPQDAAGLRTCIEALCDDDIAWQTAQTGDNQPWQVNDVSTAELNAKTLQRLPGDNWRVTSYSGLQQRGHGIAQDLMPRLDVDAAGVASVVEEPTLTPHQFPRGASPGTFLHSLFEDLDFTQPVDPNWVREKLELGGFESQWEPVLTEWITAVLQAPLNETGVSLSQLSARNKQVEMEFYLPISEPLIASQLDTLIRQFDPLSAGCPPLEFMQVRGMLKGFIDLVFRHEGRYYLLDYKSNWLGEDSSAYTQQAMAAAMQAHRYDLQYQLYTLALHRYLRHRIADYDYEHHFGGVIYLFLRGVDKEHPQQGIYTTRPNAGLIALMDEMFAGMTLEEA", "function": "A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and highly processive (>30 kb) ATP-dependent bidirectional helicase. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator, 5'-GCTGGTGG-3') sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to Chi site, by nicking one strand or switching the strand degraded (depending on the reaction conditions). The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang which facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA. The RecBC complex requires the RecD subunit for nuclease activity, but can translocate along ssDNA in both directions. Probably interacts with a component of retron Ec48 which moniters RecBCD stability; when RecB is missing or impaired the retron is activated and becomes toxic (Probable).", "AFDB_id": "AF-P08394-F1-model_v4" }, { "swissprot_id": "P11557", "sequence": "MDEFKPEDELKPDPSDRRTGRSRQSSERSERTERGEPQINFDDIELDDTDDRRPTRAQKERNEEPEIEEEIDESEDETVDEERVERRPRKRKKAASKPASRQYMMMGVGILVLLLLIIGIGSALKAPSTTSSDQTASGEKSIDLAGNATDQANGVQPAPGTTSAENTQQDVSLPPISSTPTQGQTPVATDGQQRVEVQGDLNNALTQPQNQQQLNNVAVNSTLPTEPATVAPVRNGNASRDTAKTQTAERPSTTRPARQQAVIEPKKPQATVKTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPAAGAKTAGNVGSLKSAPSSHYTLQLSSSSNYDNLNGWAKKENLKNYVVYETTRNGQPWYVLVSGVYASKEEAKKAVSTLPADVQAKNPWAKPLRQVQADLK", "function": "Non-essential cell division protein.", "AFDB_id": "AF-P11557-F1-model_v4" }, { "swissprot_id": "Q7JVA5", "sequence": "MSTRNVMITDLDQPDPNQQQHHQNPKKNRKVLQTLSGNFNRRSRSVEVEVKRQDNLGVVHKDRKKDRSFNSLLQAKDQQLEQLVQRLATLHRYNDQFAKENDQLRKDSGQLERRLTEAEQQVANCSRCQQLGQRLDTVLAQNRTLAGDVDMLKTLVFRLNVQIESYQDQRRLGEGAPTCGGSTKVSSSSAPYPPLPTHTLGPLLQAYDESLRDKDALLAQYNTEFEHFTGELKRALEENTKLLQSQEQLRRDLGGWREERVCLQAQLGVCRSKAEAQTRKTDLAKEKLVEVMHCYEQRMQTLILDMDHLQAAYARTKSELAALKSASSAAPAAVAPPVPAESEALHQCKALLEQLRQEHARERTCLQEQLQATTARAASLVRSTEKAKHSRDRLKARLRMALQWAQKLEAGQAEVRDTYEAVRRLEVLVQHKESQLRGLHARNAEEMDKLRHKLQQKEETICALLRGKMERRPAVD", "function": "Required for mitochondrial complex IV activity. May be involved in non-associative learning.", "AFDB_id": "AF-Q7JVA5-F1-model_v4" }, { "swissprot_id": "P0DP43", "sequence": "MPSAGQRKPGSLLALQALQKWLLRGGVGAMLARQVVAALLLWLSCCVSALWRYYINSQDYSIFSTRSSIKLEYEGNSFVSWKIPESCKVENTTSPKTTLHCKRAGIHTIKPIAGNQEVERHLTVDNSYICYLWYFTVVDVYYNLSQIVTIWVYDPESASTEELIWTAKKPSLSSRVLTKQMNTLGQRPFIFTVEKRLTYHPGPLTSEGTWVIHLPMSSDDIAKVIRGNKVAFQDCFIANLYFMLTYPMTIISEPPGYEPLTVPPGSPLMLSWDTCISTFALLATDQETFQTNDSFQTWTRVRAPPGILSDAQRHSLRDVIIFDQGTLFLVDGTVYLRTEDEFTKLDESRGISETGILGFSKRRWCQIRYLYKLASKKSILIAWSKTTVYAGYATFRFVTLTDTAKLKDFLKLPQTDTLEVMSVEYLWHPLEAAVLLSHCSVCTTNTRNIRIVIYSAIFQTWTLQDFELQLPKEAILEFRFLYSAMPDIIMWDQHHVYYSYKNFTVVGTISTPSGETNLSSLSQGSKIHQVLTDRIGNVVVKMENNVMFYIKADITEAVILHTWVNTTAKTVVLFDKSFEVCILYYNENLDEKYQLQTQPYPLILELQSINKDLGDWCPYLAFQHNIHSQFYHMDKGESLTIWSQIVYPENRGLYIVVEHYGSSVMTWTQNLEYEIASGFCTKTMITRFFQTTNYELVDNYYQLQKENTGLMLLQFRPSEFSRTCLTAKPVFEIDVGCDSSKYIMVRGFNKSRCQRRDFSYVIDKELLRESLSDNLKVRYDVAKYGCPLTLELGQMFQPIVELYDENGFIKIVDANFILWEIHGRNDYTFNSTMEQNGCINEAQTWDSMIEENPDIPLDDVWGPQNYRPCFSYAIGKPGDLGQPYEILNYSNKNHIKWPMTYAGMYVYRLKILDPNYSFCNLTTIFAIESLGMIPRSSVYLVAALIFVLMLTFISILVLSYFWYLKIYRQFIIEPLHKRPAKQKKN", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.", "AFDB_id": "AF-P0DP43-F1-model_v4" }, { "swissprot_id": "Q9N281", "sequence": "MDVTKKNKRDGSEVTERIITETVSTRLTSLPPKGGTSNGYAKTGSLSGGSRLEKHSLTHGSSGYINSSGSTRGNASTSSYRRAHSPASTLPNSPGSTFERKIHITRHGTYEGSSSGNSSPEYPRKEFASSSTRGRSQTRESEIRVRLQSASPSTRWTELDDVKRLLKGSRSASVSPTRNSSNTLPIPKKGTVETKMVTASSQSVSGTYDATILDANLPSHMWSSTLPAGSSMGTYHNNVTTQSSSLLNTNAYSAGSVFGVPNNMTSGSSTLHPGVSTCSSVFGMQNNLAPSSSTLSHSTATASTAYGMKKNLPQSPAVVSTGVSTSAACTTNVQNEDLLHKDCKFLILEKDNTPAKKEMELLIMTKDSGKVFTASPASIAATSFSDDTLKKEKQAAYTADTCLVSDANGDVKTVSTKGKAASAEMHNYNHRGGGSGGGGGGGGGGGGGPWGAAPAWCPCGSCCSWWKWLLGLLLTWLLLLGLLFGLIALAEEVRALKARVAELEQSRSNVLLFKEEMQRANKDWLQGEAPSVEAGGKLGLDGHQQEELWLFVRNRLMAEQENGNLRGSPGPKGDMGSQGPKGDRGLPGTPGIPGVLGHPGPQGPKGQKGSVGEPGMEGPMGQRGREGPMGPRGEPGPPGFGEKGDRGAAGEPGVQGPPGVPGSVGPKGSGGSPGPRGPPGPMGPQGLRGEVGLPGIKGDKGPLGSPGPKGDQGEKGPRGLTGEPGLRGLPGAVGEPGAKGAVGPAGPDGHQGPRGEQGLTGMPGTRGPPGPSGDPGKPGFTGPQGPQGLPGTPGRPGAKGEPGAPGRIMTSEGSSTITVPGPPGPPGAMGPPGPPGAPGPRGERGLAGESFMGSSSSISELLSTRSFKEPMQTCHRASFLEARVAKTTPALSGRHCVLDTCRKGVDLRGPPGPPGPPGPPDLPFRVRQDPEAPQVKAELPGKRYESIGTQSLGLALGKSLPATSPQHRVLETYFSGPPGPPGPPGPKGDQGSSSLGLNLQGPPGPRGPKGDKGGSSSSTMFMPGPPGPPGPPGPPGSISSSGREIQQYISEYLQSDSIRSYLSGVQGPPGPPGPPGPVTTIAGETFDYSELASRVSSYLQTSGYSIGSSVSISTEDIVAALQREYLRRAGGWEPWGLGLPLPELLRASEEALVLVPSGQGRPGCGRAVAREPCGLGGPTPALPVLAGDDVRQYLRQYVIGDWSLQSLDYAELSSRILSYMSSSGISIGLPGPPGPPGLPGTSYEELLSLLQGSEYRGIIGPPGPPGPPGIPGNAWSSISVEDLSSYLHTAGVSSIPGPPGPPGPPGPRGPPGVSGALATYAAENSDSFRSELISYLTSPDVRSFIVGPPGPPGPQGPPGDSRLVSMDGSYSRDSRSSSHSASVSRGSSYSSSMGIGGASGGSLGEAGAFGLDMGLGRGYGGAAEGGMYGGEGGPLGAGFAGGLDYNELAVRVSESLQRQGLLQGMAYTVQGPPGQPGPQGPPGISKVFSAYSNVTEDLMDFFRSKSTSVIVFLTPCCPVRGALQDHQVGLGHPALEGTREKKETKVTKSMRGGEREASPSSHELPLEEQPLASVLAMAYGVHVKISPKGGSWRLTSY", "function": "The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion.", "AFDB_id": "AF-Q9N281-F1-model_v4" }, { "swissprot_id": "Q6ERW7", "sequence": "MSRHFRTHTTSRLTFPSSSGGLAITRLPFSSTSSKLLLQQLSSTSPAAAATAVTITTSSPARNLQRARASAAEQGMEEHGKAAVGWAARDDSGVLSPYNFSRRAQKDDDVTIKVLYCGICHTDLHIVKNDWGNAMYPVVPGHEIVGVVTGVGAGVTKFKAGDTVGVGYFVASCRGCECCGNGYENYCAKMVTTCNGVDHDHGGGAATQGGFSDAIVVNEHYVLRVPAGLPLDSAAPLLCAGVTVYSPMVIHGLNAPGKHVGVVGLGGLGHVAVKFAKAFGMRVTVISTSPGKRQEALEHLGADEFLVSRDAGQMAAAAATMDGILNTVSAWHPIAPLFSLMKPMAQMVFVGGPTRPLELPAYAIVPGGKGITGNCVGGIRDCQAMLDFAGEHGITAEVEVIKMDYVNTAMERLEKNDVRYRFVIDVAGSSLAGSGDAKI", "function": "Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.", "AFDB_id": "AF-Q6ERW7-F1-model_v4" }, { "swissprot_id": "P0A1X3", "sequence": "MIRHGSNKLKIFILSILLLTLSGCALKSSSNSEKEWHIVPVSKDYFSIPNDLLWSFNTTNKSINVYSKCISGKAVYSFNAGKFMGNFNVKEVDGCFMDAQKIAIDKLFSMLKDGVVLKGNKINDTILIEKDGEVKLKLIRGI", "function": "Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Pilot protein that is required for the proper localization of the secretin MxiD/SctC in the outer membrane. Also influences both MxiD/SctC multimerization and stability.", "AFDB_id": "AF-P0A1X3-F1-model_v4" }, { "swissprot_id": "Q10B79", "sequence": "MKFGKDFRSHLEETLPAWRDKYLAYKSLKKLIKNLPPDGDPPPVAAAAEVPAGDGDGDGGIALGNWFARVLDMELQKLNDFYIEREEWYVIRLQVLKERIERVKAKKNGAFTSKSEFTEEMLEIRKAFVIIHGEMILLQTYSSLNFAGLVKILKKYDKRTGGLLSLPFTQRARHQPFFTTEPLTRLVRECEANLELLFPIEAEVLESASSSAKLQPQNDDAASHDPASSVDVETSDVYRSTLAAMKAIQGLRKASSTYNPLSLARFFHGEDGEACSGAITSESDSYSDSQIEDAEDDDKEVQSREQNTAQNAAEGQPRDE", "function": "Inositol polyphosphate sensor that associates with transcription factors to regulate Pi starvation responses. The SPX domain provides a basic binding surface for inositol polyphosphate signaling molecules. Interacts with PHR2 to inhibits its translocation to the nucleus and repress its DNA-binding activity, and then negatively regulate Pi signaling.", "AFDB_id": "AF-Q10B79-F1-model_v4" }, { "swissprot_id": "Q9MA87", "sequence": "MNSPLSSKNLRIFSKSVACKCLVLVGIALFYRALLLSYSPRNALSNSLLFRDRHMSDSSSTGGIRTDKFLEVPQIVWGLNNQKIAFARACLTARMMNRTLLMPSLSASLFYKEVDKLRPIPFDKVFQFERFNSLCSGFVRLSRFSDVKNRAQVFDLEKGSGRRWTVERDLEHLKQSARNESIDEFEVIRLIGKNPFLWHDHWPVEDYAKVFECMVVVDEISREADKVVMKIREAGEAERAKLASKTEILGPVPFVAVHMRIEIDWMIHCKKLEQRKKISEICSSKREILDRVGNISGLKTPTVLYLAVADTLLEEKEEDSSVLSGWRDGLIPFEKKKLGVKEEIYGKYSYLIQSAIDYEVCLRADVFVGNSFSTFSSLIVLERTQKARRLGFMSSCKDGGNKWRSYAYNLAGESNGVPRRWMTNMTHSSLQAISYGSNSVSCSSG", "function": "Probable protein O-fucosyltransferase required for correct pollen tube penetration through the stigma-style interface. May be involved in protein O-glycosylation events during pollen-pistil interactions.", "AFDB_id": "AF-Q9MA87-F1-model_v4" }, { "swissprot_id": "Q9D0B1", "sequence": "MDNPSSDPLPSTLSGEEEKPLALLPPVPRGRRGRPPGGATTSNRTLKSSLPRKRGRPPRSEQETPLTAPVDSGGSSDLLLIDDQGVPYTVPEGSAADGPQGSGSKRAPHFCPVCLRAFPYLSDLERHSISHSELKPHVCKDCGKTFKRSSHLRRHCNIHAGLRPFRCVLCPRRFREAGELAHHHRIHSGERPYQCPSCRVRFTEANTLRRHYKRKHPELVGMPVRLCPPNPRTQPLWDDDEGIPVQEGVQEESPEGKEPTWPISSTTSPLSGFTAGGSAGAGRGQEGQDTLVSGGIPTMEGDQKQGPKPLGPGAIGHPPVD", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q9D0B1-F1-model_v4" }, { "swissprot_id": "Q7Z2Z1", "sequence": "MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL", "function": "Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.", "AFDB_id": "AF-Q7Z2Z1-F1-model_v4" }, { "swissprot_id": "B1ZWP0", "sequence": "MLPLFLAAAEAHVAEPGLVAELVEKFGLDPKYILIQTFSFLIVLGILYRFAIKPTIAAMEERAEKVGAGLKYAEEMQAKLAAAQQESAAIVKKSQVEASRIVDEARRTAKDYLDKQTQEAAAKASETIAKAQQAIELEHRKMLADARTEIARLVVITTERVLAQKLSDSDRAAYNASATRELTNV", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-B1ZWP0-F1-model_v4" }, { "swissprot_id": "Q96P63", "sequence": "MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNESKEPDPCLKSNKQKAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFYGRVCSP", "function": "Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. May play a role in cell differentiation.", "AFDB_id": "AF-Q96P63-F1-model_v4" }, { "swissprot_id": "P41260", "sequence": "MSLSAAQKDNVKSSWAKASAAWGTAGPEFFMALFDAHDDVFAKFSGLFKGAAKGTVKNTPEMAAQAQSFKGLVSNWVDNLDNAGALEGQCKTFAANHKARGISAGQLEAAFKVLAGFMKSYGGDEGAWTAVAGALMGMIRPNM", "function": "Serves to transport hydrogen sulfide to autotrophic bacteria.", "AFDB_id": "AF-P41260-F1-model_v4" }, { "swissprot_id": "Q47VQ7", "sequence": "MTWLTAFKDKNIVVLGAGMTGLSCLRFLHAQDLSFAVNDSRPMPFANRDEQTQYENDYPKAKFVFGQWQQSLISSADIIITSPGIDLVSEGITALIPENCLVIGDVELFCLVNNSRISPMKMLAVTGSNGKSTVVSLLASLAKAIGVNAALAGNIGEPILNLLHRENVYNSQLANQPDIVIVELSSFQLETLSSMHAIAASVLNLSDDHLDRHKTLANYQAIKQSIYPQAKIAVVSREDQASNTLVAAQEIISFGLNKPEQDCFGLQAIDNKMVMMFGEQALISIDELPLAGMHNALNYMAALALGYSAGWSLSAMTENLAGFMGLAHRCQRVASEDYIQWINDSKATNVGATLAAITGLVPTLTGQNKLILIAGGDGKGADFSALTTILNCDVNQLITLGKDGAEIASLVSDAIQVDTLREAVEQAKQIAKPGDMVLLSPACASIDMFKNYQVRGEQFIAAVQAKEDSCR", "function": "Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).", "AFDB_id": "AF-Q47VQ7-F1-model_v4" }, { "swissprot_id": "Q54WY5", "sequence": "MEEETKVVKKVTGPAKPQKLRSIDVELAQKLNTGSSQTKSSALYKLRSVVKNEKLTEIQLLKIWKGLFLSLYNTDKPIVQEEFSRDISKLTTYFKDYKDSLMFIKCFFIILQKHWDYIDKYRVDKFYSLVRKMLNSSFQILKKRNAQHEEGSEEEEARLALNEQIYSGLVKIFKSTVLNTSSDSTTNTNGVLLHFADIYLEELFKVTQGHMEPINLTKILLPFVNFLTKSEDDVSCKRIKERVFDRLLTTYSPFDKKDAYYLPKVGVSSSTPEIFPTDYEMFSKLFFKCASSKDTLEQNRKTLYGLKNQFKRAQAALEELEELADNIVLDENGDIVENPNVNPEDLQGDDSDDSDEEFDVDQMDSEDSGEGEFDDEIDADDAEELDDDDDEEFDEELDEEDEEEEEEEEEEVPPPPPTKNLKSKPSPVTQKNKQQQQQPPAKPAPITKKQQQSPAKPTQVTKKQQSPAKPTPVTKKQQSPVKPTSPKVVKKPTRK", "function": "May be involved in the generation of 28S rRNA.", "AFDB_id": "AF-Q54WY5-F1-model_v4" }, { "swissprot_id": "P61070", "sequence": "MEKKVYSVDGKELRTINLDDKVFGLPVNDDVIYYAINNELANKRVGTACTKGRAEVHGSNSKPYSQKGTGRARRGDKKSPLLVGGGTIFGPKPRDFSYSMPKKAKRLAMKSILSLKAQNDRLVVVEDFTVESGKTRDLVKILDNFAKGERAVIILKDDDSLVKRAGRNIPHLSFLAYNRLRAHDLFYGRKVIMLESAAKNLSEFYGCKEAE", "function": "Forms part of the polypeptide exit tunnel.", "AFDB_id": "AF-P61070-F1-model_v4" }, { "swissprot_id": "P26326", "sequence": "MLRALLPSTTLALILAGGGHAAVGDAFPAFAVLCAAWDAATNKQIKPWSEDRELPELNDIYNMNMSIASEEWQTIFDGQAEQQTWSQFAQANAGKYKGIDWKQNWDRWRKQRQQTKDAGGAWQTKNHRPEWAATPRDVRPVILAIAEEATELSRKLEPPRTADGKDLIAEINSKLASARCSGELKAAAGNIGCTGPEGTPDKTTTCTTAKAGGSIGHDMLCLCSVAEATDKCSSTGVGDAVPNSGEKLRSNGFQHIVARCPKGPESGTLPQAIDLALAMLATALGTQQPGSNNMILGKSGGGTCTATNSACVDYHEKFSKQQAGITGIPWVALLQQARALYGTYVDAKLAAQTARQQIVMLAGQAKREYRRPAGSLKDPAGVIQEQATNRRRHGADDTNQCTSNNATADECPETRCEYDSEKNECRPKKGTETTATGPGERTTPADGKANNTVSDSLLIKTSPLWLAFLLF", "function": "VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.", "AFDB_id": "AF-P26326-F1-model_v4" }, { "swissprot_id": "Q2V3N5", "sequence": "MDRVGSLPDELLSHILSFLTTKEAALTSLLSKRWRYLIAFVPNLAFDDIVFLHPEEGKPERDEIRQSFMDFVDRVLALQAESPIKKFSLKCRIGVDSDRVDGWISNVLNRGVSELDLLIILGMTMEDSYRLSPKGFASKTLVKLEIGCGIDISWVAGSIFLPMLKTLVLDSVWFYVDKFETLLLALPALEELVLVDVNWLDSDVTISNASLKTLTIDSDGHLGTFSFDTPSLVYFCYSDYAAEDYPVVKMENLREARIFLLVTDNEIERVRLPINDGLEDAMDNVVLRFGHVGKLMNGIRNVEYLELSADTLEVLSLCCESMPVFKNLKSLAIKSTEGRGWQAMPVLLRNCPHLEFLLIEGLLHHVTDKCGDACDCVPREDKGRSLTSCPVNMLEIHGFRGTKKEMQMIKHFLDYFPSLKEMDIYADEDGPTNLEAPGMFEQITQLFTLYDEFYTCDVQFMVRGSLYKKLTAQCCVFKEENLPHRLVRTLG", "function": "Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.", "AFDB_id": "AF-Q2V3N5-F1-model_v4" }, { "swissprot_id": "Q948U0", "sequence": "MRGLPGHERRWTSDTVSSGKDLSGESSPGTDSGNISGFASEEFVEVILDLQDDDTIILRSVEPATVINIDASDPATGVGIGGVSIETPASLTSTSGTRSPTMRRSTSNKLRQFSQELKAEAVAKAKHFSQELKAELRRFSWSHGHASRTFSPASFFQNAVVGTGNGVDSALAARALRRQRAQLDRTRSSAHKALRGLKFISNNKTNGWNEVENNFAKLAKDGYLYRSDFAQCIGMKDSKEFALELFDALSRRRRLKVDKISKEELYEYWSQITDQSFDSRLQIFFDMVDKNEDGRIGEEEVKEIIMLSASANKLSRLKEQAEEYAALIMEELDPERLGYIELWQLETLLLQKDTYLNYSQALSYTSQALSQNLQGLRKRSPIRRMSTKLVYSLQENWKRIWVLVLWILIMIGLFLWKFYLYKQKSAFQVMGYCLLTAKGAAETLKFNMALILLPVCRNTITFLRSTKLSCFVPFDDNINFHKTVAAAIVTGIILHAGNHLVCDFPKLIHANNTNYQKYLVNDFGPSQPQYIDLVKGVEGVTGIIMVILMAIAFTLATRWFRRSLIKFPKPFDRLTGFNAFWYSHHLLIIVYIVLIIHGTFLYLVHNWYSKTTWMYLAVPVLLYAGERTLRFFRSGLYTVRLLKVAIYPGNVLTLQMSKPPQFRYKSGQYMFVQCPAVSPFEWHPFSITSAPGDDYLSIHIRQLGDWTQELKRVFSEACEQPEAGKSGLLRADENTKTSLPKLLIDGPYGAPAQDYRKYDVLLLVGLGIGATPFISILKDLLKNIVTMEEQADLVSDFSGNSDMSAATSEQPALNKISPKKRKSTLKTTNAYFYWVTREQGSFDWFKGVMNEVAELDQRGVIEMHNYLTSVYEEGDARSALITMVQALNHAKNGVDIVSGTSVRTHFARPNWRKVFSKTLTKHANARIGVFYCGAPILAKELSKLCKEFNQKGTTKFEFHKEHF", "function": "Calcium-dependent NADPH oxidase that generates superoxide. Involved in the rapid and transient phase I oxidative burst induced by pathogen infection.", "AFDB_id": "AF-Q948U0-F1-model_v4" }, { "swissprot_id": "J9VVN9", "sequence": "MASHTLRPHRSPSPSPEPPVNLANPAKLTRQSLGPPTSGNSKGFGSLGLGPGLASPSSPSQPRHVSSSVAMGMGNRDSLSPRPSGVGSGRAVSATTGPRPSSEFIPTREAKTPEAEQIDQWFKHLANWEATLEEMAAASTDQNFTEELGAIEQWFRVLSEAERTAALYSLLQYSTPVQIRFFISVLHHMSQSDPMSALLSPSLSGSNAFQTQVESKLSNMNLKSPSAGGGAGFAGSSGNGHYLAPDDAAAKAAKARQNRISAPGTLQPHDRWQGQLDQVVERGTSPGLESNMSGRSRSKSPTPEPRPKSTDFSGKPRESLRRESAAFPRSPRVSAGSPGIGLGIGHESPMASPFGNNASWASMVNTPLVQNFNDGKLVAPASVADLSQALNMATLQLNNPGYLPLDDARKYRRPTGGLASGQTSRNVSGQYNDDGEIVNPHTTQPGTPSGLLPNQFGGGRSPLVDQFGLGGLGIGADSTTLANLGLNYNLAGLGGVNPGLNGLTAAQAQAAQMLAMQQQLQNSQYSPFNASAPSLQPGLNPSRRGAGRGQSSHLNQHYNQHQQQHQPGRRSPNPLKSHSPAPGQQTGGGGAGGGAGVAGPEDVDVKVLEDVPNWLRVLRLHKYTPNFEKSNWNDMVLMTDQDLQDNGISAQGARTKFLKVFYNVRTKMDIAHPPGQEEYAPGPKESK", "function": "RNA-binding protein involved in post-transcriptional regulation through transcript degradation.", "AFDB_id": "AF-J9VVN9-F1-model_v4" }, { "swissprot_id": "A3DH61", "sequence": "MKRVILHCDLNNFYASVECLYHPELRDKPVAVCGSIEDRHGIVLAKNYAAKKYKVKTGETVWEAKNKCPGLVVVKANHSLYYKFSKYARQIYEYYTDRVESFGLDECWLDVSESTLLFGDGTKIANEIRERIKRELGVTVSVGVSYNKVFAKLGSDMKKPDAVTVITENDFKEKIWGLPVEALLYVGDSTKKKLNNMAVFTIGDLANCHSEFLVRQLGKWGYTLWSFANGYDTSPVAKNDCEIPIKSIGNSLTAPRDLTNNEDVRILIYVLSESVGERLRSHNLKGRTVQISIKDPELQTLERQAGLDIHTSITSEIAQKAYEIFLKSWNWSKNVRALGVRVTDLVESDTCTQISLFSDDIKRQKLEILDECVDRVRERFGYYSVRRGILLQDRGLNRI", "function": "Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.", "AFDB_id": "AF-A3DH61-F1-model_v4" }, { "swissprot_id": "Q6KCA4", "sequence": "MSLTEDNNNTTITIAKGENKEIILHGNPTTGYSWVVDSCEGLSNTVEYVADQHAPGICGCGGKYHIKITGTQTGEGKIVLVYRRPWAPNANDRTFTLKVNVQ", "function": "May serve to protect the cytosol against cysteine protease molecules released by damaged intracellular vesicles. Inhibits papain and soluble trophozoite extract.", "AFDB_id": "AF-Q6KCA4-F1-model_v4" }, { "swissprot_id": "Q9KAV6", "sequence": "MHSPVLLLIDGFNLLSRGYFATSYGKDEAQLPRNEAGYYINALRVFFPKLFQLIREHNVTHVAVAWDVKREDSHRRQAFAFYKASRGELPEALIEQYETATSLLEEIGVAQVTIPPYEADDTIGAFACRWAKEEKGHCFIYSNDRDLLQLLSKSTSQIISSKGKDLIYTEENFRNDYNISPAQWVDVKALLGDKSDNIPGCPGVGEKSALPLIQQYGTIETLYEQIEDLDPKYKRYHKKLVAGEESVIISKELATITTEIEAISSFSLNSLVLTTPADLIIDTLARCGIRVKLAPVQTELKLG", "function": "5'-3' exonuclease acting preferentially on double-stranded DNA.", "AFDB_id": "AF-Q9KAV6-F1-model_v4" }, { "swissprot_id": "Q8NEY8", "sequence": "MWSEGRYEYERIPRERAPPRSHPSDGYNRLVNIVPKKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDRRSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPEISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIESAGQTWQQVPPVRNTEMDHDGTPENEGEETAQSAPQPPQAPQPLQPRKKRVRRTTQLRRTTGAPDITWGMLKKTTQEAERILLRTQTPFTPENLFLAMLSVVHCNSRKDVKPENKQ", "function": "Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin. Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation.", "AFDB_id": "AF-Q8NEY8-F1-model_v4" }, { "swissprot_id": "Q9HXE4", "sequence": "MSAATPLIVQQAEAEQLLARIDVLQAMRQLFLDLAAGQALQPAQQLVEFPAGRGDFINYLGVLAQEQVYGVKTSPYIVREQGPLVTAWTLLMSMQTGQPLLLCDAARLTTARTAATTAVAVDALAPAEACRLALIGSGPVAHAHLQYVKGLRDWQGVRVHSPCLDERRLQSLRAIDPRAEAAGSLEEALDEADVILLCTSSARAVIDPRQLKRPALVTSISTNAPRAHEVPAESLAAMDVYCDYRHTTPGSAGEMLIAAEQHGWSPEAIRGDLAELLSAQAPRPEYRRPAFFRSIGLGLEDVALANALYRLRQAG", "function": "Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium.", "AFDB_id": "AF-Q9HXE4-F1-model_v4" }, { "swissprot_id": "B1B3P3", "sequence": "MGSMLLASFPGASSITTGGSCLRSKQYAKNYDASSYVTTSWYKKRKIQKEHCAAIFSKHNLKQHYKVNEGGSTSNTSKECEKKYVVNAISEQSFEYEPQTRDPESIWDSVNDALDIFYKFCRPYAMFTIVLGATFKSLVAVEKLSDLSLAFFIGWLQVVVAVICIHIFGVGLNQLCDIEIDKINKPDLPLASGKLSFRNVVIITASSLILGLGFAWIVDSWPLFWTVFISCMVASAYNVDLPLLRWKKYPVLTAINFIADVAVTRSLGFFLHMQTCVFKRPTTFPRPLIFCTAIVSIYAIVIALFKDIPDMEGDEKFGIQSLSLRLGPKRVFWICVSLLEMTYGVTILVGATSPILWSKIITVLGHAVLASVLWYHAKSVDLTSNVVLHSFYMFIWKLHTAEYFLIPLFR", "function": "Involved in the biosynthesis of sophoraflavanone G (SFG). Can use flavanones (naringenin, liquiritigenin and hesperetin) as substrates, but not flavonols or isoflavones. Shows a strict specificity for dimethylallyl diphosphate.", "AFDB_id": "AF-B1B3P3-F1-model_v4" }, { "swissprot_id": "Q1GZJ0", "sequence": "MSCLLAIDAGNTRTKWAVLQYETGEILQRGVLNDDMPAEWALCERVAVANVAGPNRQALLEARLKLLGLPVRWHASTLHACGVSNGYAIPAQLGVDRWAAMIAAWQHYQRSCLVVNAGTALTVDMIESTAPGQACFLGGIIMPGIRLMQESLASAAANIGAMHGVFRDFPLSTQDAVCSGSLHAGAGAINNLLTLLGERCGEAIPCILSGGDAVALLPLLQKHILHSEFCLEENLVLQGLWYMERGLP", "function": "Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.", "AFDB_id": "AF-Q1GZJ0-F1-model_v4" }, { "swissprot_id": "O97862", "sequence": "MARSLGVPLLLLAALVVALALAVSPAAGARTRQSPRLLGGLEDVDAQEKDVQRALGFAESEYNKGSNDRYHSRALQVVRARRQIVSGVKYYLDVLIGRTTCTKTQTNLANCPFHDQPDLQRKMLCSFEIYSVPWLNKISLLKSDCQNA", "function": "This is a thiol proteinase inhibitor.", "AFDB_id": "AF-O97862-F1-model_v4" }, { "swissprot_id": "Q2G278", "sequence": "MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVTKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH", "function": "Has weak lytic activity toward S.aureus cells.", "AFDB_id": "AF-Q2G278-F1-model_v4" }, { "swissprot_id": "Q9Z1L0", "sequence": "MCFRSIMPPAMADTLDIWAVDSQIASDGSISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAEKLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEHEPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEEEASPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINRNSSSLPLPLPPKKTRVISHVWGNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASGDSANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEVHTPAVSIQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAMKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCRYMDSKMKPLWLVYSNRAFGEDAVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS", "function": "Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase activity showing autophosphorylation.", "AFDB_id": "AF-Q9Z1L0-F1-model_v4" }, { "swissprot_id": "A5WI39", "sequence": "MTDYCYPKAKRLLKPAEFKPVFNQPLFKVHQTHFMAFAYDSDHLQARLGMAITKKKIPTAVARNTIKRIIREQFRHTHAQLPALDVVFILKKSTKALSNEQMRQEISDILSKVISKQRRATAADVKHKDK", "function": "RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.", "AFDB_id": "AF-A5WI39-F1-model_v4" }, { "swissprot_id": "Q5ABR2", "sequence": "MSPDAIRVVVCGDDAVGKSSLITSLIKETIIEPQTNNVLPPITISRNDYIESSQEYLNDQDHHHHHQSSPSTMKNKRKHNNKRERERERESSINNVQPNEISEYIPNITTIIDTSSSDMTNLQKELKRADVIWLVYSDHYTYERISLHWMPLFRSMGVNLPIILCANKSDLFPKSKSNLKSTNSDEFVPLINEFKEIEAGVRCSAKNNYNVVEAFYLCQRAVTHPISPIFDAKEGNLKPGAIKPLKRIFWLSDTDQDGYLNFEELSELHKKCFGIEASKSDYEEIVNLIDQKILPSYNTTIETQTPPQQQHLATSAGTPNGTTTTTSKGISEDGFILLNKIYAESGRHETVWCILRAYHYTNSLSLSDKFLYPRLDVNPHSSVELSPTGYKFFVDLFIKFDKDNDGGLNEDELNTLFRSTPGIPKLWVESNFPSSIVCNEEGYVTLQGWLAQWNLTTFLSYKTTLEYLAYLGFDEGNSTKALKVTKPRKIRQKNGKTYRNAVNDRNVFNCFIVGAPKAGKSSLLESFLHGSYSDIYSPTIQPRLVVKDIELRGGKQCYLILEELGELEPAILENKSRLDQCDVICYAYDSSDPESFQYLVELREKHGHLLDEVPAVFVALKADLDKQQQRCDVQPENYTRDLFLNSPLHVSLAWNSSLHEMFIQLVDAAKTPSSATPGIELEVSVDQDDIKHIIMTGAAIAVVGLVSIWVLNSLRR", "function": "Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.", "AFDB_id": "AF-Q5ABR2-F1-model_v4" }, { "swissprot_id": "O58231", "sequence": "MIAMDIREIGLRLVGEAIKAADPYRAVLNAVKVSDDKIIVQGKEFEIKGKVYVIALGKAACEMARAIEDILDVEDGVAVTKYGYGKELKRIKVIEAGHPIPDEKSILGAKEALSILNRARENDIVFILISGGGSALFELPEEGISLEDLKLTTDLLLKSGAKIHEINTVRKHISKVKGGKLAKMIKGTGIVLIISDVVGDNLEAIASGPTVKDPTTFEDAKRILELYDIWEKVPESVRLHIERGLRGEVEETLKEDLPNVHNFLIASNSISCEAIAREAQRLGFKAYIMTTTLEGEAKDAGLFIGSIVQEIAERGRPFEPPVVLVFGGETTVTIEGKGGKGGPNQEIALSATRKISDLEALIVAFDTDGTDGPTDAAGGIVDGTTYKKLREKGIDVEKVLKEHNSYEALKKVGGLLFTGPTGTNVNSIVIAIVTSKRGRT", "function": "Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP or pyrophosphate as phosphate donor.", "AFDB_id": "AF-O58231-F1-model_v4" }, { "swissprot_id": "Q2V4B2", "sequence": "MAISKPPPLHFTFFHNQDSSIDTSDSNLALSIDTSRRRRDVLLTISGTLIPQLFFFDRKRSSSANAADFFNFGAPPPEPERTVELAQEGLRKNAENIKRIKEIMIEKKLWKEGGKELRRSASNMKQDFYLIIQAKPPKDRPLFRSLYSSLFNSITKMDYAARDGDETKVLEYYINIVAILDDIFPRI", "function": "Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex.", "AFDB_id": "AF-Q2V4B2-F1-model_v4" }, { "swissprot_id": "Q9HDZ3", "sequence": "MFANFRNCFKIKNSRLIYDNINKCLLTKEETNQLLKFIHLKWKPAKDQVQISFSRSSGPGGQNVNKLNTKVIVNLPFKQLESCIPMFLINHFKTCEMLRNYRIQNGIKIYSQKTRSQHKNIEDALNKISDLLNKSAETLYVPDTPPEKIARISILKKESNEKRLSEKKYKQKKKTQRRITMD", "function": "Has a role in meiosis.", "AFDB_id": "AF-Q9HDZ3-F1-model_v4" }, { "swissprot_id": "Q73JM1", "sequence": "MKKNTVLAVVLSMLVFGGWLYIQQKYFPTEYNVPQKPVAQAQGQNPTSSEIAVQTSSNQISNSMIEAVADSDYPSREQTYVIETDIIRAVFTNKGGDIISYKLKEHASAGSDERVEMIENVTERNRALSLALGGHDAQAVDLLFNVKEESLSDGRKQIGFYRDIKLKNTDGSETVFTLAKRYTFIPGDYMFTLEVTIDGKEGMRGLSFGDSAYTLRSAPQIGPEWDKVNDKYEYRALSYFANEKKKEDRSITDGKTKAVNDLASWVSVSGKYFSFIIIPKDPIQKMFFSGIKEEGAKLHNSQFFISRQPIVGNAAYDQYRVYIGPSSEKILNSYNSAAANNYGYENLRIDSLAASSGFLAPLERVLKFVMEIFYKIIPNWGVALLLLTLLMRIIFFPLTKKSSEATKRMQELQPQINELQQKYKNNPQKLNAEMVKFYKEAGYNPASGCLPLLIQLPFLFAMFGLFNNYFEFRGASFIPGWIPDLSVGDSILKFGFTIPFLNWTDLRLLPIIYTASQLLHGKLTQTPGQSQQNPSMKIMIYFMPLFFFFLFYNAPSGLLLFWTFSNILMLLQQLIINKSMKK", "function": "Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.", "AFDB_id": "AF-Q73JM1-F1-model_v4" }, { "swissprot_id": "D4AVW3", "sequence": "MLSSVLFPAMRTLLLLKYVFSLISLSAICCQTVSAIPVVSREGLPMTLSDKCAEALISDVACDPNVLDFKPGYYYSPEILQRACTDTCKSALDSYLDRVKSSCGTETIVGPFDLEVSALIVPGMRKDLFQKTCLQDNGRYCNNVAATAAVIADPGVSRFNYLSSVPPGTVPPDPCDIQHVCLYVDDQSMRNIWATIDYYSYWVLYIINAGCYNMHRLNGTELCISAPGQKFVPGDATDLPGATVTTPVPAPSDAASGSNRYCGRWYGVKKGDYCNLIVLKFGITMDNFIFLNPALNSNCTNLYAEESYCVLPVGDINTYSGKPGYVSTPTGSETTATGIRFEDLPDATENPYPRPPPGPPIAEGTRDDCNYYFDGAEFQYNVTNTYWNSNCQIPPPQVYRVDPESFESWNAGLGNISRPECSFKPGFRYCGRYYALSDDSDEPTPTTPITTSDDPTSTSATPTTPTTSSKPSPGAPTMTGQPSACNKWHTVTNGESCTVIPKTFGITLEQFLAWNPTVKSDCTENFWAGYAYCVGVKTLGPS", "function": "Might have a role in sequestration of chitin oligosaccharides (breakdown products of fungal cell walls that are released during invasion and act as triggers of host immunity) to dampen host defense.", "AFDB_id": "AF-D4AVW3-F1-model_v4" }, { "swissprot_id": "Q82XD1", "sequence": "MTHSQYIFGFHAITSRLRQHPDSIKEIYLDTNRHDQRARDLMSLAETTSTRLILCEQDRLCKMTGTTRHQGVAAHVTKLRRYATLEDLLEGLTEPALLLVLDGVKDPHNLGACLRVADAFGVHAVVVPKDRAVGLSATVHKVASGAVDTVPFFAVTNLARTLRELKEMGLWIVGTAADAPDTLDSVTLTRPLAWVLGAEDGGMRRLTREACDLLVSIPMSGSIESLNVSVSAGICLFETFRQHSQRTGSGLNVPAPKNAV", "function": "Specifically methylates the ribose of guanosine 2251 in 23S rRNA.", "AFDB_id": "AF-Q82XD1-F1-model_v4" }, { "swissprot_id": "J3QMY9", "sequence": "MERTALAVCEILRYLIIHWKCEAGTAKGTLLDGQLVISIEALRSKHLPDSLHCIITIASTRSVYGGLNFKKFLQEIQPALPRLSAKLALASEEGGRSQDASGIAPCQVTFEVDENSQSLMTDCLVIKHFLRKIIIVHHKLKFSFSVAVNGTLSAETFGAENEPTLRLDNGVTLVVGFQRYVSKPKLNWSEAHCSRIHPVLGHPAPLFIPDAKADTGLLGELTLTPAAALCPSPKGFSSQLCRISSVSIFLYGPLGLPLLSSDQDQPSTAVFRDTSYFIDWKKYNLFMVPNLDLNLDTQSVLPDVNYKAESPEGNQSQNMNAQGPALLLFLFVDFQSDVPVQQAKIWGLHTLLTAHLSAILSESRSTVQQSIQSAVDQVWQLYHHDAKTQQRLQASLSVAVNSIMSVLTGSTRSSFRKTCLQALEAADTQEFGVKLHRIFYDITQHQFLKHCSCDTEQHLTPEKNISAQNTKDQHKNIAQEFPEESIGQAENKRPKRGSPNHGREESRVLGSARDRSPPKSATRDRELTEVSLTARGSQTQAAHGRAQAAEAASPAGGLEDLWLQEVSNLSEWLNPGHRS", "function": "Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.", "AFDB_id": "AF-J3QMY9-F1-model_v4" }, { "swissprot_id": "Q04786", "sequence": "MASDIDQKDVDYAAKNLKLTTSLVANKPKDCPPEAPWGACYRVEINLENTGSKSLNENVEIYFSSIHRTLGSKSEEFKVEHINGDLHKITTTEKFKGLKGGKTKSFQVDFMNWIVSNSDFMPNYYVASEHLEGRNILNTVPIDAVHITEEVSGFTTGIKHTPNQLKRTANDLLPAATATTRYEQYSKVKDLGADAVSAHILPTPLETSVHEGSLNIAQGINIVSDALPADQVEALNFRFETLGVNTGTGVPVNVTIKADSSKKSGSYTLDVTSSGIRIVGVDKAGAFYGVQSLAGLVTVGKDTINQVSINDEPRLDYRGMHMDVSRNFHSKELVFRFLDQMAAYKMNKFHFHLADDEGWRLEINGLPELTQVGAHRCHDVEQNKCMMPQLGSGAELPNNGSGYYTREDYKEILAYASARNIQVIPSMDMPGHSLAAVKSMEARYRKFMAEGDVVKAEMYLLSDPNDTTQYYSIQHYQDNTINPCMESSFVFMDKVIDEINKLHKEGGQPLTDYHIGADETAGAWGDSPECRKMFVAPESGVKNAKDINGYFINRISHILDAKGLTLGAWNDGLSHKALDASSLAGNPPKAWVWGTMFWGGVDQYNSFANKGYDVVVTPPDAYYFDMPYENDPEERGYYWATRFNDTKKVFSFMPENVPANVEWMTDRMGAKISATTGEKTHDFLGVQGALWSETIRTDAQVEYMVLPRMIAVAERGWHKASWEEEHKEGITYTSNVDGHEGTTHLNDNIATRDADWAHFSNILGYKEMPKLDKAGITYRLPVLGAVIKNNILDVVTEFHGVAIQYSLDGKTWHKYDDTKKPQVSTKALVRSVSTNGRTGRAVEVLAK", "function": "Hydrolysis of terminal, non-reducing N-acetyl-beta-D-glucosamine residues in chitobiose and higher analogs, and in glycoproteins.", "AFDB_id": "AF-Q04786-F1-model_v4" }, { "swissprot_id": "Q9FAW5", "sequence": "MKLVVINGTPRKFGRTRVVAKYIADQFEGELYDLAIEELPLYNGEESQRDLEAVKKLKTLVKAADGVVLCTPEYHNAMSGALKNSLDYLSSSEFIHKPVALLAVAGGGKGGINALNSMHASLAGVYANAIPKQVVLDGLHVQDGELGEDAKPLIHDVVKELKAYMSVYKEVKKQLGVE", "function": "Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH as an electron donor for its activity. Compounds with paired naphthalene groups coupled with the azo group are good substrates, with the following preference order: Rocceline > Sumifix Black B > Solar Orange.", "AFDB_id": "AF-Q9FAW5-F1-model_v4" }, { "swissprot_id": "O94411", "sequence": "MIIKKKESFKSPGRLWRVTKIRKLTAAKKNELQNRKCNQASNEEKKILYKSNFLDRFIPSKANSDAFRIMENAFTEKLNTQESLLPDILNLNVKGVLHYKDNKKQKTTRLIESTNYQRQTIHGASSSLVIEVEENGHLSNMQGSLYETPLRILDAPGLLDDFYISPLAWSTNGELAVALAQNVYLWSEISGPSIMELSPTTYEVSSLAYSSDGGFLAIARVNGFVEIWNRKTKNNRCDYKFHHDGDISCMAWSPINWTLLVGGSTGNIYVYRRTKSMMRRVHTIKKVHQEQVCGLEWNYDGTQFASGGNDNLVCIFDIDSLENKKFYWIHLAAVKALAFCPWQKSLLAVGTGSNDQQIYFYDTFRGHRIHSLFCGAQVTSVIWSRRYKEFCYSLGYSPEGTNSSLIVYRWPQLTKVFDIPSAAIDGWGQDLRTIMAIHTHRKYSNNTWEEGEYVVVANSDETVKFYKIWGNEMQEIHNDRVLYREGIFGSHILEMLENIPEQVLTNGVR", "function": "Has a role in meiosis.", "AFDB_id": "AF-O94411-F1-model_v4" }, { "swissprot_id": "Q9WWU5", "sequence": "MSNAALATAPHALELDVHPVAGRIGAEIRGVKLSPDLDAATVEAIQAALVRHKVIFFRGQTHLDDQSQEGFAKLLGEPVAHPTVPVVDGTRYLLQLDGAQGQRANSWHTDVTFVEAYPKASILRSVVAPASGGDTVWANTAAAYQELPEPLRELADKLWAVHSNEYDYASLKPDIDPAKLERHRKVFTSTVYETEHPVVRVHPISGERALQLGHFVKRIKGYSLADSQHLFAVLQGHVTRLENTVRWRWEAGDVAIWDNRATQHYAVDDYGTQPRIVRRVTLAGEVPVGVDGQLSRTTRKG", "function": "Catalyzes the oxygenolytic cleavage of 2-ethylhexyl sulfate (2-EHS) in the presence of alpha-ketoglutarate to yield 2-ethyl-hexanal and succinate, the decarboxylated form of alpha-ketoglutarate. It can accept a wide range of alpha-keto acids including 2-oxo-valerate, 2-oxo-adipate, 2-oxo-octanoate, 3-methyl-2-oxo-butyrate, oxaloacetate-alpha-ketoadipate, and alpha-ketooctanoate. It can catalyze the cleavage of medium-chain alkyl sulfate esters such as butylsulfate, pentylsulfate, hexylsulfate, heptylsulfate, octylsulfate, nonylsulfate, decylsulfate and sodium dodecyl sulfate (SDS).", "AFDB_id": "AF-Q9WWU5-F1-model_v4" }, { "swissprot_id": "P32799", "sequence": "MFRQCAKRYASSLPPNALKPAFGPPDKVAAQKFKESLMATEKHAKDTSNMWVKISVWVALPAIALTAVNTYFVEKEHAEHREHLKHVPDSEWPRDYEFMNIRSKPFFWGDGDKTLFWNPVVNRHIEHDD", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.", "AFDB_id": "AF-P32799-F1-model_v4" }, { "swissprot_id": "Q46851", "sequence": "MVWLANPERYGQMQYRYCGKSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGRLLREDFAAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVTSVLIGASRAEQLEENVQALNNLTFSTKELAQIDQHIADGELNLWQASSDK", "function": "Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.", "AFDB_id": "AF-Q46851-F1-model_v4" }, { "swissprot_id": "O14164", "sequence": "MSRFFKGGSSDSDAESVDSSEENRLTSSRLKKQDDSSSEEESSEEESASSSESESSEEESESEESEVEVPKKKAVAASEDSESDSESSEEEEETESEEDSEVSDESESESESESESEEESESEEESDESERSGPSSFLKKPEKEEAKPAGLKFLRGESSEESSDEEEGRRVVKSAKDKRYEEFISCMETIKNAMSSNNWIVVSNEFDHLNKVSQKCKEAGRNPPPYIEFLSALDQKLESADKAFIKSLDAANGRAFNALKQRVRKNNRQFQSDIDRYRKDPEGFMKPAELNEIPKPAGKAGQDEVIVDGVATRGIVAPTEGLGKPEEITPADIFKYLRAIFEARGKKSTDRSEQIRLLEKLSTIAVTDYQRLRVKVALLAVRFDINTGSGQYMPIDQWNAALTELHSILDIFDANPKIVIVEQVEDENEEEEEAIAAAENNNGVIQVQGSVVSFLERLDDEFTRSLQMIDPHTPEYIDRLKDETSLYTLLVRSQGYLERIGVVENTARLIMRRLDRVYYKPEQVIRANEEVAWRSFPPTFDLTITPRATTTTPDILIHSLCVYLYNNGVSLLRTRAMLCHIYHEALQNRFYKARDMLLMSHLQDSVHAADIATQILHNRTMVQIGLCAFRNGMVQETQYALQDISTTGRVKELLGQGIQAPKFGQFTPDQDRLDKQLVLPFHMHINLELLECVYLTCSMLMEIPAMAAASSTASDSRKRVISRPFRRMLEYIDRQLFVGPPENTREYIMQASKALADGEWRRCEEFIHAIKIWSLMPDADKIKQMLSEKIREEGLRTYLLAYAAFYDSVSLEFLATTFDLPVQRVTVIVSRLLSKREIHAALDQVHGAIIFERVEINKLESLTVSLSEKTAQLNEANEKLYEQKTQHTNPQENRRRDKGGSVKRRNERTENRNRSDMN", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.", "AFDB_id": "AF-O14164-F1-model_v4" }, { "swissprot_id": "Q2JWE3", "sequence": "MSTDLNYSATRDPFSALGLDVGNRRIGVAGSDGLGLLATGLGVIRRRSLPEDIAQVQAWIRRRQATVVVVGIPLLADGSVGSQARKVQRFVRALQAAVDLPVVTVNEYLSTVQAEWDLRQAGIPAKAQKALIDQQSAAVILQTWLDERRYSQSSKAPCR", "function": "Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.", "AFDB_id": "AF-Q2JWE3-F1-model_v4" }, { "swissprot_id": "Q9HNP1", "sequence": "MDERAALELVGGLVSRAGDDAAVVGDTALTIDMLHDATDFPSGTTRYTAGWRSVGASLSDVAATGATATAAVAAYGAPGFDDDELAAFVTGARDVCTAVGAEYVGGDLDGHSEFTVATAAIGDADHRVTRSGARPGDSVVVTGSLGRSAAAMALFDAGDTERANDLFQFMPRVAAGRVLGAHATAMMDASDGLARSLHQLAAASDCGMAVDSGRLPVADALAEVTADPVERAVSFGGDFELVAAVPPERVEAARAAVPGSLSVVGRVTAAADGVRLDGDALADDGWTH", "function": "Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.", "AFDB_id": "AF-Q9HNP1-F1-model_v4" }, { "swissprot_id": "P38742", "sequence": "MDECLPNSCLLGVHLVISTHSGPQIVYHYPPSNTAFLTNNPTKHQHLYGNHANLNKNTSTNKEEKLFNSGSTKTASQIALNESAKSYNTAITPSMTNTNTNNVTLPPTRSHANTVGSQSSIPAATNGVGYRKTDIEDTSRTFQYQETESETSSSGLSDSELSTDYLDISSDSFSISSSLSSSSLSSSPSSSSSSSPPQDGLSRTNSSFQSTDSMSPTSPQMIMENDSISVAESYLDSGTNNKSRAASKRSQNFFHKLSTKKSTDSKTHSPVRKLKSKPSQSTKKGNKLLKNTSNETDGNAFTGSCSISSKKSLSSTGEHNQELRNSSLNDTPGQSPHHYHHRYHHYHKNAATSQRNSHTQYDVEEEDMEVSAMLQDGKISMNEIFFEEENFQDINKILEFDNDFVAEFCSPEREMCNTRFEFTVDNFCFLGLPIHVDSQGRWRKSKHKNKTRSKRSSSTTTNISRKKSIASKISSLSENTLKKVNSGEADTVYDSNIGHEASTDTPNLRINTDVSGNEFEREKEDLGKNMNMFHVCFVMNPHLIEYNKRIDDMYQFVVTRLSLLLRYVQSKTSYISSECHIILKEKERVLKHSKTYQSIRGAGNKGKYLYQRILAKSSLARALTECVDKIQRNEIACLEINDDKVISLQIPIQNEFEKMPNFKLQPVLRGSYLTSILNMKFLEKSSLRIESQNRQNDQAQFSDTNNNIYRFGNNINSTGHCGAANVDDGDDNESNYYCDDNDDLLNYALLLLDEPNNIISSLETFSYQDDIGTIILKHLVRNIQPNIPLRSYRYLITDLLDNPSSLDDLTTETNSLESSILRSCALHLMYWRHARIVIPLSSKYTYIVSPLAPIQGYTIDDYKSTSQNDGNVKKMDDRENNKSGSDRVPLIYQNSMLFRSKFPSLPSLPIFLSLLSTDKPQAYSNIIPSREHKPVYLNALAWLIQYGYVTQLLTFINIRVDKHIKMAVDEDLEKEGFRKTNTARRPSMDYKKTDKKLDDEDGQSRDANASEACSGKNEGMQSNDNNKDVDEKDNENDSRVDDRDDNEIAIADEEEILHFEYDDPEMQHDYTIILEPERATAIEKRWLYRCIYGQPSDIQILFNKLLKYFNGKVPMELVIIKEEISRHDLKKLLNALDKYLIEIHHW", "function": "Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.", "AFDB_id": "AF-P38742-F1-model_v4" }, { "swissprot_id": "Q9BYX2", "sequence": "MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA", "function": "Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.", "AFDB_id": "AF-Q9BYX2-F1-model_v4" }, { "swissprot_id": "O35002", "sequence": "MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQADSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQFSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDLNHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIAISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQIAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGKGTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPLKVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTAETLNQQIEKKKSDEKNDLQLQTALKSLFVN", "function": "Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the pre-processed regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.", "AFDB_id": "AF-O35002-F1-model_v4" }, { "swissprot_id": "P0CM31", "sequence": "MFSLPSFLTTFSFTLPSLPSISLPANIQRRFLSYVLKRTLGRFVSHQALDAERIQAQVSEGWVEIENLEIECSEINNYIPPPLPLSLTSGTINKLTAKLPFPNLWSDPLQVSLDTLTLDFTLSSPSPLSRGRAATRPEHHDLAESVTSAADDFLHHELDAYEEKELEGSIRQSLILSQTDPFISDVPGGFPLGSPGEISPGRPLPANMESTTVLAGMVERILARLEFRVEKIKIRLVIEDEEDVVELTVGRIRYADESEAQTNDDGKSTTRAIRISNISLDIVPSQRKPPSLVIPQRQSLEPSVSSSTSTASTSSGNDYSDMFMSQAVVDLRQSLLTPEQISEPANEQTVHESNMFYSALSQPNESEPGASTGIKRSGISQNPKLADEIEEERSRSETPTPETKPQPSGIPVLSFGQEDVVLHMRTTRPLISAGHQTSFNDNKPTVEMNITIGTITTVLLPSHLKLFISALQTLQALCQKDDVPAAKDKPAQSTSPQTRLTATTKLKAFYVSLVYDLSAETSLNLHSTMASHLTRPTNPIPYPHLRFRLDTLVASYQSPGHSNPSRPAFTRPTPNMSTANLRRKSSGHARFGSLPSNLTVNVGDISLFEWMGEGMIAPVILFDPGLKHQYDLPSAPPHKGQAGFPECECRDWREEKKTGSEKAWRVRPRGRGILKGGARATTEDEGPVVHVRQDLGSDSAAVINLQSLHVFVDLSLIERLLPLLRSVTPLIHPPEPTPAWLQSVPSQSISEEITPESIISSLSAPPPTARGKKMKADIRCDLVRLSVRCPAPPPEPAERQIGDGRQLRSGIVFVDVHGLKSRFMDTSRTGTRPASSEVANVEFEQTLIFFASVSQHYAYPFLIFAPLSPEPGEEDIPLLPSISLSSFPQASSLPASSIAKTTLVTCKMPAIRASVHHPTVTGLQYFADDVTRWLDVAFADGSAKPRDELKMIGSRFFGGSKGSEASSEIDEPYDVEEVAAGMKVEIEISEIDMGLYVPRLDASGERVFSFKANDLGVRMETHPEENETALELSIMDLDFSDVSSTPLRILGRTTPFTLTSHQAPVVYLRFVSSTDLRTTLKESNISVALSHFTFAVHKEIAWLHEIAQFAKPPKGVFENLSPTDLTRLSINLSSASFLLVPPNLPGSIVILVREVEGKTEIPKGATDSVLEVGMSGLGALAVEGESGPLEVSSDLADVWKKAGYAQLAEVMVLELRLMRELVAAGEVSLDITQAQFKVTACADSLATFAEIATDFGHSLDENAFNLLPEIVSHSDTDMIEDDLPHNLDYLDHATRISKHYPSMDRTTGENLRAWHTPEEGLEEGEWENGESGETIRAFGGEIEEEEGYWEGLPILNDVYSADQKPGKIHIRVLDASLKIFLHDGYDWPRTRKAIEDEVRAVRRRLERIRQLLASGQKADESIENATSSVLFNSIYIGLEQKGEMGLSTMGMGKMDEKALMAAIDEELDGMETESGSSWQTLPAGVGAGPSAVHQAHKKTRLKGKRLVRSKKAQIEITLSGIKTDVDLYPTEESTSSRVHFTAKEMEILDHIKTSTWKKFLTEMKADNRGNIRETDADMLRIELVGVRLKEDEEELRLRAKILPLRLHVDQDALDFLKRFFSFKAPPMTSARPLAQHTTSSTPDLYFQHVEIFPIQLKLDYKPKRVDFRALREGKTIELMNFFHFEGAEMTLRHITLSGITGLERLGTTLQDLWTPDVKANQLADVISGVSPIRSMVNVGSGVADLILLPIEQYRKDGRIAKGVQRGTNSFVKSTALEVMKLGARLATGTQVILERAEGVLGGKSGEDVVGQVQGLSTNAFGVDSGMLEGGSSSEDEQEAISRYADQPESMKEGVQAAYKSLSKNVNAAAQTILAVPMEVYERSGDDGPLKAVIRAVPIAVLKPMIGTTEAVSKTLLGMRNSLDPSARRELDDKYK", "function": "Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.", "AFDB_id": "AF-P0CM31-F1-model_v4" }, { "swissprot_id": "Q8L4E7", "sequence": "MLLPPHPGRTLPAYHGDNRFLLGACFLSKLPMLRPMKLSLVCSANPNNHRSRSSDITRHQKGGSARRKSKPYQEKDDSENIDEFDTDIMSSKNGPPISLTSNSRPQATSVPGEREKEIVELFKRVQAQLRARGKGKEEKKPEQAKAQGERGSVDSLLNLLRKHSVDQRRKSGDEKEQSVDQTKRSNESGNKQNSSIFIKNDTQEEQKKPHPAAFKRPASNFRRRSPVPNVKFQPVTNVDAERVINNINDAVQEAKPTLENKAATDEPDSVSTFEPNSVIEPENLSLDDLDHISDDEPDASDTDEPSGEYDEPSLQIPSVPIIDESHDTTLKSSLGGPDLSTLKVTELRELAKSRGIKGYSKMKKNDLVELLSNMA", "function": "May regulate cell proliferation and plant growth.", "AFDB_id": "AF-Q8L4E7-F1-model_v4" }, { "swissprot_id": "P25185", "sequence": "MNALKGRDILALGFMTFALFVGAGNIIFPPIVGLQSGPHVWLAALGFLITAVGLPVITVIALAKVGGSVDALSHPIGRYAGGLLAAVCYLAVGPLFAIPRTATVSFEVGVVPLLGESGTALFVYSLAYFLLALAISLYPGRLLDTVGRFLAPLKILALAILGVAAFLWPAGPIGTAQPEYTQAAFSQGFVNGYLTMDTLAALVFGIVIVNAIRSRGVQSPRLITRYAIVAGLIAGVGLVLVYVSLFRLGAGSHAIAADASNGAAVLHAYVQHTFGSLGSSFLAGLIALACLVTAVGLTCACAEYFCQRLPLSYRSLVIILAGFSFIVSNLGLTKLIQVSIPVLTAIYPPCIVLVALSFCIGLWHSATRILAPVMLVSLAFGVLDALKAAGLGQDFPQWLLHLPLAEQGLAWLIPSVATLAACSLVDRLLGKPAQVAA", "function": "Component of the LIV-III transport system for branched-chain amino acids. BraZ is specific for isoleucine and valine. The LIV-III transport system may be H(+)-coupled.", "AFDB_id": "AF-P25185-F1-model_v4" }, { "swissprot_id": "Q9FFX4", "sequence": "MAEPPPSYLHFVGPAKTRSSSKRHSFSSSAHPASHRLFPCQYCPRKFYTSQALGGHQNAHKRERAAARRNLGVLANSPPILDDNNTFLRPYPCFYQNPFQGSTSGNEPLQEQPTMMTMDGYDPFHPYPYVYPFALSGNNNDGGNGVMEEDEPLDLDLSLRL", "function": "May function as a transcriptional repressor of cellular proliferation that regulates floral determinacy and relative size of basal pattern elements along the proximo-distal axis of the developing gynoecium.", "AFDB_id": "AF-Q9FFX4-F1-model_v4" }, { "swissprot_id": "Q9FGS4", "sequence": "MALALSVAPTSSSLSSLLSRTPNPSPNFRTTHLNFGSQRRIYTINPLLRSFKCLQSSSRDVNASPFSISAIASSSSSSQTTELVPYKLQRLVKEFKSLTEPIDRLKWVLHYASLLPQMPESSKTESNRVMGCTARVWLDAELGQDGKMRFCADSDSDVSKGMCSCLIQVLDEASPVEVMELKTEDLAELNVGLLGGERSRVNTWYNVLVSMQKKTRRLVAEREGKVPSFEPFPSLVLTAHGIEAKGSFAQAQAKYLFPEESRVEELVNVLKEKKIGVVAHFYMDPEVQGVLTAAQKHWPHISISDSLVMADSAVTMAKAGCQFITVLGVDFMSENVRAILDQAGFEKVGVYRMSDETIGCSLADAASAPAYLNYLEAASRSPPSLHVVYINTSLETKAFAHELVPTITCTSSNVVQTILQAFAQMPELTVWYGPDSYMGANIVKLFQQMTLMTNEEIANIHPKHSLDSIKSLLPRLHYFQEGTCIVHHLFGHEVVERIKYMYCDAFLTAHLEVPGEMFSLAMEAKKREMGVVGSTQNILDFIKQKVQEAVDRNVDDHLQFVLGTESGMVTSIVAVIRSLLGSSANSKLKVEVVFPVSSDSMTKTSSDSSNSIKVGDVALPVVPGVAGGEGCSIHGGCASCPYMKMNSLSSLLKVCHKLPDLENVYGGFIAERFKRQTPQGKLIADVGCEPILHMRHFQANKELPDKLVHQVLSCESKR", "function": "Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. Can complement nadA-deficient E.coli mutant. Essential for the de novo synthesis of NAD. Participates also in cysteine desulfurization mediated by NFS2. Can activate the cysteine desulfurase activity of NFS2 in vitro.", "AFDB_id": "AF-Q9FGS4-F1-model_v4" }, { "swissprot_id": "P36892", "sequence": "MDPQTAATLLPLLGWALHGSVLTRRLASARRDPLTGLHTRAGWTARAEHCIHRHPRAAVLLVDLDHFKTLNDTHGHAAGDAALIATAHRLSSWCGRHGTAGRLGGDEFVTAIRDLDAVDLDALTTALHQPTNYDGTALPLAASVGVCRVAELPVPALTDALAAADAAMYAAKGRSRRGSRPAR", "function": "Might be involved in pSAM2 replication control.", "AFDB_id": "AF-P36892-F1-model_v4" }, { "swissprot_id": "P40566", "sequence": "MPAKIHISADGQFCDKDGNEIQLRGVNLDPSVKIPAKPFLSTHAPIENDTFFEDADKVSFINHPLVLDDIEQHIIRLKSLGYNTIRLPFTWESLEHAGPGQYDFDYMDYIVEVLTRINSVQQGMYIYLDPHQDVWSRFSGGSGAPLWTLYCAGFQPANFLATDAAILHNYYIDPKTGREVGKDEESYPKMVWPTNYFKLACQTMFTLFFGGKQYAPKCTINGENIQDYLQGRFNDAIMTLCARIKEKAPELFESNCIIGLESMNEPNCGYIGETNLDVIPKERNLKLGKTPTAFQSFMLGEGIECTIDQYKRTFFGFSKGKPCTINPKGKKAWLSAEERDAIDAKYNWERNPEWKPDTCIWKLHGVWEIQNGKRPVLLKPNYFSQPDATVFINNHFVDYYTGIYNKFREFDQELFIIIQPPVMKPPPNLQNSKILDNRTICACHFYDGMTLMYKTWNKRIGIDTYGLVNKKYSNPAFAVVLGENNIRKCIRKQLSEMQKDAKSMLGKKVPVFFTEIGIPFDMDDKKAYITNDYSSQTAALDALGFALEGSNLSYTLWCYCSINSHIWGDNWNNEDFSIWSPDDKPLYHDTRAKTPTPEPSPASTVASVSTSTSKSGSSQPPSFIKPDNHLDLDSPSCTLKSDLSGFRALDAIMRPFPIQIHGRFEFAEFNLCNKSYLLKLVGKTTPEQITVPTYIFIPRHHFTPSRLSIRSSSGHYTYNTDYQVLEWFHEPGHQFIEICAKSKSRPNTPGSDTSNDLPAECVIS", "function": "Ergosteryl beta-glucosidase involved in the ergosteryl beta-glucoside (EG) catabolic pathway and vacuole formation via hydrolysis of EG to generate glucose. Is also able to hydrolyze cholesteryl beta-glucoside and sitosteryl beta-glucoside to generate glucose; and C6-7-nitro-2,1,3-benzoxadiazole (NBD)-GlcCer to generate C6-NBD-ceramide (Cer).", "AFDB_id": "AF-P40566-F1-model_v4" }, { "swissprot_id": "Q2RI40", "sequence": "MSTKDLFAEPNLKQITVWARGVVMNKDARDIVVALTEAAAKEGKYVQAWENYVDLPDRIYVPVRAYARISSDPIESKYIYENETPDIVVLVEESLIKGVPILKGIRPGSTLVVNTKRSIDTILEFLGDTGNLAQIVTVDANSMAEAVMTLSGAEGATDATGIGAGIAAPIAGAVVKATGIVDVENLAAVVKNPAAMRRGYAEAQVRQLPPHEAVEEAAVSATELLRQMPFAGTVPSPVTENEGMVTGNWRIQRPIIDREACTECYTCWIYCPDSCITRTEEGPVFNMKYCKGCGLCTAVCPSGALTNVPELDFKD", "function": "Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel-dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria.", "AFDB_id": "AF-Q2RI40-F1-model_v4" }, { "swissprot_id": "Q9PPG2", "sequence": "MMKSRDKKDLILESIIQTYLLDNAPIGSNELNSNLCIPASTIRVYLKRLSDEGLITQLHISSGRIPTILTMQNYWQNFWEKEQDKNIHIKNESFLKELSKEFEIYCLVYGGRSLVLKEVLDLNTKFIVLDFEDEELVLKYEKEAWNFLQSLIGLDLSSIEKIALRVHFIDLVEKIASLRQNLICYRSNEERAYQIYQNDEFVKLLDCQIHRHFKESLEFEPLFKEGFMGLKVDAQFLGEDVNIILAGSVYTDYKKILQYIKEAA", "function": "Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.", "AFDB_id": "AF-Q9PPG2-F1-model_v4" }, { "swissprot_id": "F5ZAY7", "sequence": "MFHNTCGRKGRFARAMGMALAISVTLSGCSTVSDWFADEEELEIRRLKPIDAKFTPSVKWDRDIGDGVDHYFSRLRPVYAYENLYAADRHGSVVAMNPENGDVLWERDFAVFEGDGWWDSIARLWRSGASARIGGISVADRLLFVGTENGVVMALDYETGETKWEASVPGEVLAAPSADEGILVVNTGAGTLFGFDTRTGEQLWRHEGDTPPLTLRGISGPVAANGGALIGTPTGKLQVNLLESGILAWETVIATPTGATELERIVDLDTTPVLFGGTIYTVSYNGTLAAVELRSGRIIWKREYGSYRNLSIEGNSIFVVDNNSNIYALDRRNGVELWSQGSLKSRSVTAATPVGEHIVVGDNWGFVHWIEQETGQIVARVDVGGDDEDDAIYDAPLNVDGVVVTMTRNGVVAAISTL", "function": "Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.", "AFDB_id": "AF-F5ZAY7-F1-model_v4" }, { "swissprot_id": "Q9ZUM2", "sequence": "MRIGGVEVTKFASEMMSSSSSSAVEMLNLKEASNWWSDVNESPIWQDRIFHVLAVLYGIVSLVAVIQLVRIQLRVPEYGWTTQKVFHFLNFVVNGVRAVVFVFRRNVQFMQPEILQHILLDIPSLAFFTTYALLVLFWAEIYYQARAVSTDGLRPSFFTINAVVYVVQIALWLVLWWKPVRVMVILSKMFFAGVSLFAALGFLLYGGRLFLMLQRFPVESKGRRKKLQEVGYVTTICFTCFLIRCIMMCFAAFDEGANLDVLDHPILNFIYYLLVEILPSSLVLFILRKLPPKRGITQYHQIR", "function": "Contributes to the intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.", "AFDB_id": "AF-Q9ZUM2-F1-model_v4" }, { "swissprot_id": "Q2EEX4", "sequence": "MTILAWIKDKKNKAILNTPEYSSQSSLSWCFTHKEAASNKAVSFINLSKRRALWTRCEKCGMIQFMRFFKENANLCLSCSYHHIMTSDERIALLVEKGTWYPLNETISPKDPIKFTDTQSYAQRIQSTQEKLGMQDAVQTGTGLINGIPFAIGIMDFRFMGGSMGSVVGEKLTRLIEYATKQGLFLLIVSASGGARMQEGIYSLMQMAKISAALNVYQNEANLLYISLCTSPTTGGVTASFAMLGDIIFSEPEAIIGFAGRRVIQQTLQQELPEDFQTSESLLHHGLIDAIVPRCFLVNAISEVASIFAYAPSKYKKLGNISHYHENTLSWATEEILRRNCINNKKVEYRTIEKIYQTTLYKESFFRLNKLLSKLKSEINFTNKMKKQNNAFNTSSVYANYYDVMLCNYNIGTHSLNLLFNEESEFCKYFPFNMDHMKKENRIKYNFITENSNDFIRKKTINDFSIMLIGD", "function": "Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.", "AFDB_id": "AF-Q2EEX4-F1-model_v4" }, { "swissprot_id": "Q72E85", "sequence": "MSSFKEFKIKWGMVIDLDKCTGCGACMVACQAENNIAPQPDASNKLKSLNWLVVYELNNGKPFPEHDVAYLPRPCMQCGKPSCVSVCPVVATDKNEEGGIVSQVYPRCIGCRYCMASCPYHARYFNWFDPTWPEGMDKTLTPDVSVRPRGVVEKCTFCHHRFMQAKDKARVEGRDPSALRDGDYVTSCTEACPNGAIIFGDFNNPEHRVHELHKSKYAFRLLERLGTDPQVYYLSRREWVRRLGDNYLEHEKVKG", "function": "Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. QrcC is an electron-transferring subunit; its cubane iron sulfur clusters form a pathway for electron transfer between the hemes of QrcA and the membrane quinone pool.", "AFDB_id": "AF-Q72E85-F1-model_v4" }, { "swissprot_id": "A0A0H2ZJS4", "sequence": "MVAGAVAGALIGAAVVAATAATGGLAAVILAGSIAAGGLSMFQIVKGLTTIFELPEPTTGVLIRGSFNVYVNSRNAMRAGDDVSATCSGLPLNHPLWPFPVLIAEGSATVYINGKPAARLQSKMVCGAHIKTGSQNTFIGGPTERVAFVLDLEEWLHTGLEALGLAALAGGLLLAAMAGVAALVGVVAIGGLMMGGMALLGDLGDRLGPGYRDLFQGVAGMALLGFGPKMARLGNAPKGAPKTQVPKGFEKVYGKAPAAKAEIDAVADGLAAKHGGRVAKAPIKSRERAMQKINNDYKGDPTKIKDLARNTIIVEGDKVNTVAAELANRGAKVKVIDGNADPLGYSGVNSTMNTKAGIPGEIQVNSPEMIYAKESEDMARILLGNDTYDAVAAKAGVPGGQGHKYYEDWRVLDPKSPEAQAIAEKSRAYYDAVRKGNGN", "function": "Type VI secretion exported toxin that pyrophosphorylates adenosine nucleotides to produce (p)ppApp. Thereby, depletes cellular ADP and ATP to dysregulate central metabolism in competitor cells.", "AFDB_id": "AF-A0A0H2ZJS4-F1-model_v4" }, { "swissprot_id": "Q7VGA8", "sequence": "MSAQPKPQLMGHIIAGYPSFESSLYAALGICQAGASYLEVQFPFSDPNADGRVIEEACNKSIAQGFKVAQGFKLLHTLSQHINQDNKQPTRLIIMTYANLIFHYGIEAFIKEAKKCGVWGIIAPDLPIESDESLRILAKKHHIRIISLIAPKVSISRIKKIAKISDEIVYVVARAGITGEKTHIDKALFEWIRLIQKHCKKPIALGFGINSYEQVAALKDKVDIIVAGSYFVRFISELSTQSQLSPQDYMHKLQAHAQMLMGWDINE", "function": "The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.", "AFDB_id": "AF-Q7VGA8-F1-model_v4" }, { "swissprot_id": "Q9CZJ1", "sequence": "MSAAFRKAAKTRQREHRERSQPGFRKRLGLLEKKKDYKLRANDYHKKQDFLRALRKKALEKNPDEFYYKMTRAKLQDGVHIFKENKEEVTAEQLKLMRTQDIKYIEMKRVAEAKKIERLKSELHLLDFQGKQQKKHVFFFDTKKEVERFDVATHLQTAPELVDRVYNRPRIETLQKERVKGATPQTGLKRIAKERQKQYDCLTQRIEREKQLFVVAQKIQTRKDLMDKTQKVKVKKETVNSPAIYRFQTRRKR", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA.", "AFDB_id": "AF-Q9CZJ1-F1-model_v4" }, { "swissprot_id": "Q53143", "sequence": "MRRSLTAGLALVLIAGAAGLWLTRPVKSDPELFAGLTGEASRGERIFWAGGCASCHAAPDASGEARLVLSGGERLTTDFGTFVVPNISPDPDHGIGGWTVADLDSALRHGTSPERSHYYPSFPYTSYAHVEPQDVADLKAFLDTLPPSDRADEPHDLAFPFNQRIILGGWKLLAGGPSWIVEGDLAPEEERGRYLVEGLGHCGECHTPRNGLGLRDKSRWLAGGPNPEGRGTIPNITPAKLDWSAGDIAEYLSSGFTPDYDSAGGQMADVVRNTSQLPDEDRRAIAAYLKRVPAIE", "function": "Particularly expressed when cells generate energy via aerobic respiration.", "AFDB_id": "AF-Q53143-F1-model_v4" }, { "swissprot_id": "B8NI22", "sequence": "MTMLSDLPKIPTLDWADFAEGDTDQRLKLAQGLVQGFKRFGFVKLVNHGLSDELIQQLFAEVKRFYRLPDELKQKAAHPPGPNPQRGWSGIGVESTSKLYGEQTERPSGKLKDAKVGTDFSSSKLSRELTHMKEHYDIGPPTDTQFPTRWPDEQDIPGWRAFMESYYARGQSFCLDLMEALEIGLELPKNTLRSMCIPDGSELRLLHYPEIPAAELRTGDTARIWPHTDFGLITLLFQDGVGGLEVEDPLQQGHYIEVAREQPYEMIVNVSATFERWMNGVIKAAVHRVNITPEGKHVEDAVVPERWSAAYFFKAHKMAHAGPLPAFVTPERPALYDNITALEFQKRRTDLVYTGQQLKVEEAA", "function": "2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination. ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors. N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline. Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation. The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH. Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins.", "AFDB_id": "AF-B8NI22-F1-model_v4" }, { "swissprot_id": "Q9A3H7", "sequence": "MRLDQVRAALDRRLDPASRAPLAVGFSGGGDSLFLLKTVLDWARPLDRPVLALVVDHQLQPQSTAWTAEAVAKARALGAAALGLTWTDQKPRTGLPAAARRARHALLATAAREAGARVLILGHTASDLAEGVAMRAEGSSVSNPRAWAPSPVWPEGRGLFVLRPLLTLTRAEIRDALTREGETWLDDPANLDLRYARARARAAGALTPLLPVRESPPPGVFEIDPAGAIRLPRDVVPAHLAAALLCASGAERPPRGDRLARLVERLRSGARFTATLAGARIEADQAVLICRDAGEAARGGLARLDLAPGACGVWDGRWEVVAGKTALAVVALRGRTSSLPAEQRARLSAIAPAVRPSLPVLLSLDGDAPGELVLDDLQLEADGEARVRSLVPDRFKAAVGLLDQESVT", "function": "Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.", "AFDB_id": "AF-Q9A3H7-F1-model_v4" }, { "swissprot_id": "P40186", "sequence": "MELSSPSKKTTTSPINIPGGNRDNLIIGPHSHSFKTDPFSSNNSSLLSKISTNPSLESPFSSKSLLDCSPVQAVKKSLESEAKTHSLDEETNEQTDVKILNIADFPTDELILMISALLNRIITANDETTDVSQQVSDETEDELLTPILAFYGKNVPEIAVVQYLERIQKYCPTTNDIFLSLLVYFDRISKNYGHSSERNGCAKQLFVMDSGNIHRLLITGVTICTKFLSDFFYSNSRYAKVGGISLQELNHLELQFLILCDFKLLVSVEEMQKYANLLYKFWNDQ", "function": "Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. The PCL7-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase. PCL7-PHO85 also phosphorylates MMR1 and YJL084C.", "AFDB_id": "AF-P40186-F1-model_v4" }, { "swissprot_id": "P45450", "sequence": "MNSKLSLFDIRTFLESCLLSVTNLSEDIRINNICTDTRSLVSGDLFLALRGESFDGHSFIPQALTAGAIAVVTDRPVEGLGETVAQFLVEDTLVAYQHIAAGWRQRFTIPIIGVTGSVGKTTTKELIAAVLSQFGNVHKTRANYNNEIGVPKTLLELSPDHDFAIVEMAMRGRGQIALLADIAKPTIGLITNVGTAHIGLLGSELAIAEAKCELLAHQPPESTAILNRDNALLMETAQRFWQGKTITYGLEGGDVHGTVDGENLILDGVSLPLPLAGVHNASNYLAAIALAQCLGLDWQQLQSGLTVELPKGRARRYQWGQDVVLLDETYNDGLESMLASLDLLANTPGKRRLAVLGAMKELGDYGPTFHQRVGAKVKALGLDGLFLLANDPNTDAIAAGANGVETQSFSDGPSLVAALKTTLQPGDRLLFKASNSVGLGAVVSQLLAENPTSV", "function": "Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.", "AFDB_id": "AF-P45450-F1-model_v4" }, { "swissprot_id": "Q08729", "sequence": "MPRKFLGNKIEKNVDAVRPSSLTLTADDLKYIPPIPQDFEDEDDKVLRTSNGGNRLSKRFGGTLKLKKRLESVPELFLHDFKKRPRSQLEVIREKKFTDMQVPKGPVCPQSTILPLRERKKVKSLPIQRKSLRRPTLSKPAVVQSLGHKTHSDHIIDKVFVSRPAPIVMPVKALTPINPVSLMQTQTQDCCRKNKYGKSGSEILFDEILSAYENVSTSDSTALNSEIDRIIDICASKQIAKKNEAFQVPYVVCPDDTETLFSSTTPKLKPVNSNTLNDVISSPEYTTSGCSTYSDQSNSDEELSEVESIVWNTNKRTMRSSIVSESTSEEGYCTAAETLPSTVSVEDLDIHNKLPKVAQTSSCNTLLNKLSIRKLKKVILDPPKIMHVMTFDDDSDDGDDNDDEDRALNILQKKIDCIEIASCSSSIYSE", "function": "May be involved in the establishment of the daughter fate.", "AFDB_id": "AF-Q08729-F1-model_v4" }, { "swissprot_id": "F4J264", "sequence": "MAAKIIGGCCSWRRFYRKRTSSRFLIFSVRASSSMDDMDTVYKQLGLFSLKKKIKDVVLKAEMFAPDALELEEEQWIKQEETMRYFDLWDDPAKSDEILLKLADRAKAVDSLKDLKYKAEEAKLIIQLGEMDAIDYSLFEQAYDSSLDVSRSLHHYEMSKLLRDQYDAEGACMIIKSGSPGAKSQIWTEQVVSMYIKWAERLGQNARVAEKCSLLSNKSGVSSATIEFEFEFAYGYLLGERGVHRLIISSTSNEECSATVDIIPLFLRASPDFEVKEGDLIVSYPAKEDHKIAENMVCIHHIPSGVTLQSSGERNRFANRIKALNRLKAKLLVIAKEQKVSDVNKIDSKNILEPREETRSYVSKGHKMVVDRKTGLEILDLKSVLDGNIGPLLGAHISMRRSIDAI", "function": "Involved in the light- and stress-dependent regulation of stability of 3' processed petB transcripts, thus regulating cytochrome b6 accumulation, a rate-limiting step in photosynthetic electron transport. May be recruited to specifically protect petB transcripts against 3'-5' exonucleolytic attack by masking the 3' ends. Does not function as release factor.", "AFDB_id": "AF-F4J264-F1-model_v4" }, { "swissprot_id": "P33361", "sequence": "MTYFRINPVLALLLLLTAIAAALPFISYAPNRLVSGEGRHLWQLWPQTIWMLVGVGCAWLTACFIPGKKGSICALILAQFVFVLLVWGAGKAATQLAQNGSALARTSLGSGFWLAAALALLACSDAIRRISTHPLWRWLLHMQIAIIPLWLLYSGTLNDLSLMKEYANRQDVFDDALAQHLTLLFGAVLPALVIGVPLGIWCYFSTARQGAIFSLLNVIQTVPSVALFGLLIAPLAALVTAFPWLGTLGIAGTGMTPALIALVLYALLPLVRGVVVGLNQIPRDVLESARAMGMSGAQRFLHVQLPLALPVFLRSLRVVMVQTVGMAVIAALIGAGGFGALVFQGLLSSAIDLVLLGVIPVIVLAVLTDALFDLLIALLKVKRND", "function": "Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-P33361-F1-model_v4" }, { "swissprot_id": "P35881", "sequence": "MTQFTTELLNFLAQKQDIDEFFRTSLETAMNDLLQAELSAFLGYEPYDKVGYNSGNSRNGSYSRQFETKYGTVQLSIPRDRNGNFSPALLPAYGRRDDHLEEMVIKLYQTGVTTREISDIIERMYGHHYSPATISNISKATQENVATFHERSLEANYSVLFLDGTYLPLRRGTVSKECIHIALGITPEGQKAVLGYEIAPNENNASWSTLLDKLQNQGIQQVSLVVTDGFKGLEQIISQAYPLAKQQRCLIHISRNLASKVKRADRAVILEQFKTIYRAENLEMAVQALENFIAEWKPKYRKVMESLENTDNLLTFYQFPYQIWHSIYSTNLIESLNKEIKRQTKKKVLFPNEEALERYLVTLFEDYNFKQSQRIHKGFGQCADTLESLFD", "function": "Required for the transposition of the insertion element.", "AFDB_id": "AF-P35881-F1-model_v4" }, { "swissprot_id": "P32910", "sequence": "MSGMIENGLQLSDNAKTLHSQMMSKGIGALFTQQELQKQMGIGSLTDLMSIVQELLDKNLIKLVKQNDELKFQGVLESEAQKKATMSAEEALVYSYIEASGREGIWSKTIKARTNLHQHVVLKCLKSLESQRYVKSVKSVKFPTRKIYMLYSLQPSVDITGGPWFTDGELDIEFINSLLTIVWRFISENTFPNGFKNFENGPKKNVFYAPNVKNYSTTQEILEFITAAQVANVELTPSNIRSLCEVLVYDDKLEKVTHDCYRVTLESILQMNQGEGEPEAGNKALEDEEEFSIFNYFKMFPASKHDKEVVYFDEWTI", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in recruitment of Pol III to the preinitiation complex. Involved in the configuration of an initiation-competent form of RNA polymerase.", "AFDB_id": "AF-P32910-F1-model_v4" }, { "swissprot_id": "Q8C0V7", "sequence": "MASNSKKKDVGSQYKVLFTLGHGSFGTVKLACHLKTKALVAIKMVELSKKNIRGIRAEIATLEKLQHPNIICLFQVLVTSKHINIVTEYIPGGNLFDIIKEDGPMHEEEARRIFGQVVSAVKYCHNQDIVHQDIKAQNILRDEEGNVKIIDFGLAIRCRSGTLLKRQCGTKSCFAPELVLQEPYDGKKADVWSLGVLLYFITTGYYPFRGSTMKEMEEKIATGTYDIPTHVSGQLENLIHQILTVPPEMRPSIEDIERHPWVKKTEVNNPTVTDPDYNIIEMLCGMGFDANEILESLQRKKYNESMGAYLILKAQVDKGLEHTSIISAKPVDQCPTPPPSPPAHPSISSLLLKRRASEPNFSLLHIQPSGEHRPVSLALPGHKVARSASMPPIALHYPEKKSNSSSFALHSGAVAAPSVGNSILEDELPVPPDQEYDMGACFGSTYTKQCDMETPSPPQKISRFKRMSKRIRACLAQLCCIPRAPKTKKKHTSSNKIAP", "function": "May play a role in sperm motility, especially in the regulation of flagellar function.", "AFDB_id": "AF-Q8C0V7-F1-model_v4" }, { "swissprot_id": "Q18B37", "sequence": "MNILGLIVEYNPFHNGHIYHLSKSIEKTNATHTVAIMSGNFLQRGEPALFDKYTRAKIAVENGVDLVIELPTLFACQSAEIFSHGAITILNSLNCINSICFGSEEGNTEILYNIAEILANEPNKFKLLLKKYLDDGLLFPTARANALFDYIHQDKKNNFIQNYSKEQLSKTLNSSNNILGIEYIKNLIHLNSSIKPFTISRVQSEYNSEEIESDICSATAIRTSLKENTDLFHLKNVIPEKTYNILNEKIDNGFLPMFDDFFFDILKTIILRDMDTLKEYFEVNEGIENRIYKDIFTSEFLHELQLAIKSKRYTLTKIKRTLNNILLGIKKSDMQLIKNIDTIPYIRILAFNDKGREILKEIKNKSEIKIINKFSNISFSLDDTIFKTLISYDIKATNIYNSIYYKNNKDLVKGPMDFYTHPIYVK", "function": "Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.", "AFDB_id": "AF-Q18B37-F1-model_v4" }, { "swissprot_id": "Q8CIV2", "sequence": "MSEHAAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPGGLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGADALNDSQDFPFPETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSPPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAPSTPDSSRPDPGVPLEDAPAPAGS", "function": "May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.", "AFDB_id": "AF-Q8CIV2-F1-model_v4" }, { "swissprot_id": "P42818", "sequence": "MVSSQRPVPNKIQKQQYLSISPSNSVLKDDVELEFSDVFGPLPEEANDIAYDEPAVVYSRSHSLVGPCSLDSHSLKLTKLTLLETEDSIDLVECLEGESLKENDDFSGNDDSDNEKALEGDLVKVSGVVGIDDFEVMKVVGKGAFGKVYQVRKKETSEIYAMKVMRKDHIMEKNHAEYMKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDTDGHVMLTDFGLAKEFEENTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPFLGSKGKIQQKIVKDKIKLPQFLSNEAHAILKGLLQKEPERRLGSGLSGAEEIKQHKWFKGINWKKLEAREVMPSFKPEVSGRQCIANFDKCWTDMSVLDSPASSPSSDPKANPFTNFTYVRPPPSFLHQSTTTL", "function": "Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway. Mediates the phosphorylation of MRFs (e.g. MRF1).", "AFDB_id": "AF-P42818-F1-model_v4" }, { "swissprot_id": "Q9SFF7", "sequence": "MTVKKVEIKVDINCGKCNSAIMEAVTEIEGVNHISLDEGNSILTVVGTMDPVCVATRLKKIKQKPVIISVGPPPKPPEPPKPPEPEKPKPPPAPEPPKHVCKPPYCNSCDVVSVTTYESGSGCTIL", "function": "Heavy-metal-binding protein.", "AFDB_id": "AF-Q9SFF7-F1-model_v4" }, { "swissprot_id": "A5ULI6", "sequence": "MKKVMATGTFDLLHPGHGIYLNEAKKLGGEDAKLYVVIARDSTVEKRKRYPIVGEQQRLELIKMIKGVDEAYLGNENGDFLKIVEEINPDIIAIGADQRHDITKLQKAINKRGLKAKVERVKAYHNAELDSSCKIIKKIKKMDFKGKINDNCD", "function": "Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.", "AFDB_id": "AF-A5ULI6-F1-model_v4" }, { "swissprot_id": "Q15637", "sequence": "MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN", "function": "Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.", "AFDB_id": "AF-Q15637-F1-model_v4" }, { "swissprot_id": "Q07821", "sequence": "MINTGRSRNSVLLAHRFLSTGGFWRGGTNGTMSRTINNVNPFKLKFIPKTVPAAADSVSPDSQRPGKKPFKFIVSNQSKSSKASKSPKWSSYAFPSRETIKSHEEAIKKQNKAIDEQIAAAVSKNDCSCTEPPKKRKRKLRPRKALITLSPKAIKHLRALLAQPEPKLIRVSARNRGCSGLTYDLQYITEPGKFDEVVEQDGVKIVIDSKALFSIIGSEMDWIDDKLASKFVFKNPNSKGTCGCGESFMV", "function": "Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.", "AFDB_id": "AF-Q07821-F1-model_v4" }, { "swissprot_id": "Q6AZN0", "sequence": "MPIIANDYTWEQSENDVYISVPLKGTKASASNVLCSESYLKVNFPPFLFEAFLFAPIDDSTSSAKIGNGVILFNLHKKEPAVWDALTLAHMEKEEMQKIRENAVAKEQEKAQEETKAKAERKRENEKYSLEVTMKIDEVERKRIEDVKEEERKKATEELEKWKEKQRIQKLNEMIQKKQIRQENERNKALHTGSLKHCSTATTVQNDRTINVKQKEKILPPTRSTGCIQIQFTPRVFPTALRESRVAEEEEWLHKQAEARRATNTVDLGLEDLTEEEKNPEWLKDKGNKLFAAGDYLAAVNALNLAIRLNNKIPGLYLNRSACHLKLRNLHKTIEDSSKALELLTPPVPGNASARIKAHVRRGTAFCELELYVEGLQDYEAALKIDPTNQNMKSDAEKIRRVIQSSLPDIERGIMLDIKDL", "function": "Axonemal dynein assembly factor required for ciliary motility.", "AFDB_id": "AF-Q6AZN0-F1-model_v4" }, { "swissprot_id": "P18168", "sequence": "MFRKHFRRKPATSSSLESTIESADSLGMSKKTATKRQRPRHRVPKIATLPSTIRDCRSLKSACNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAATGMELSLNPAPELAASAASSSALHRSQPLFPPCDFERELDSSTGLKQAHKRSSQILLHKTQNSDMRKNTVGSLDSPRKDFGKRSINCKSMPPSSGDEGSDVLATTVMV", "function": "Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues.", "AFDB_id": "AF-P18168-F1-model_v4" }, { "swissprot_id": "Q6MDE6", "sequence": "MSSLPPFVTTLDLKLAEKLLKDLQQQGFSITIPAYTRFSASKKGLTCTLYTSGKLVVQGKEQAHFIEFYLEPEILESFGFSHPTTKIDLTPHIGIDESGKGDFFGPLCIAGVYIQANQFSKLQALGVKDSKTLSDKTIRQLASQIKNLCLYHIVKINPAKYNEIYQDFKNLNHLLAWGHATTIEQLILQSGCQTVIVDQFADEKVVLLALKRKKLDVNLTQRHRAEDDLAVAAASILARQAFIDGLEQLSKEIQIPLPKGSSSATQKAGKEVLRKWGEERLRSICKQHFKTLDAILGKVGK", "function": "Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.", "AFDB_id": "AF-Q6MDE6-F1-model_v4" }, { "swissprot_id": "B1KJM7", "sequence": "MSKLAAFNFQQWIDEHQHLLKPPVGNVQIWENTDMMVTVVGGPNQRTDFHDDPVEEFFYQLKGDMVLKIIEEGKCHDLFIREGDIFFLPPHVRHSPQRPMPGSIGLVIEPKRPEGAKDAFEWYCFKCDGLVHRVEVLLKSIVRDLPPIYQAFYQDEQARTCPQCGELHPGKEPPQGWVTLLENKEQDKS", "function": "Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.", "AFDB_id": "AF-B1KJM7-F1-model_v4" }, { "swissprot_id": "Q8THK1", "sequence": "MSLNKAVLEIRQRIKVKPSPTNEPAASWTGTDLVNGVQTKTLTVIFKSAGCRWGKAGGCTMCGYVYDCASEPPSLEDYMAQLEKAMRKAEKFPEFMVKIFTSGSFLDEQEVLPEARDAILKNLTEDPRVTKVLVETRPNYVTEENVQACLSILKNKPFELAFGLETSSDKIRRDSINKGFTFQDFVHAAETAKKYGVTVKVYLMLKPLFLSERQAMEDIIRSIDDAAPYADTISINLCNVQKGTLVEALWEKGQYRPPWLWSIIEILRQAKAAHPELPLMSDPVGAGSKRGPHNCKICSSEVADSLRTFSLTQNPADLSTADCECKELWKKVLEIEDFTYGTPILD", "function": "Radical SAM enzyme involved in the synthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the cleavage of the C(epsilon)-N bond of the lysine moiety of q0kN15-tRNA, leading to the formation of archaeosine at position 15 in tRNAs.", "AFDB_id": "AF-Q8THK1-F1-model_v4" }, { "swissprot_id": "Q8UC77", "sequence": "MADSFKFDLVSPERLLVSETVTEVVIPATLGEMTVLANHAPTMTTIKPGLVTVKFASGETHKYVVFGGFADILPTGCTLLAESAVSADDMSPDTLQKRIDAAKAEIQEGNHHHEHLTKLEKHLYELTNLHEVLVAA", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-Q8UC77-F1-model_v4" }, { "swissprot_id": "Q1IUF1", "sequence": "MADAVILGIESSCDETAAAVIRNGAEILSSVVFSQIYTHMRYGGVVPELASREHLKAIVPVVRQAVEDAGQSYDKIDAIAVTRGPGLAGALLVGVSYAKALSFALDKPLIGVNHLEGHIHVVLLEQKQQGVGEIQFPVLALVVSGGHTHLYLAEKKDAGWTYRDVGHTRDDAAGEAYDKVAKLLGLGYPGGPILDGLAKHGDPRAVRFPFAQIKHRDRNPQNRHEDDDARVDFSYSGIKTAVLRYVETHEMKAAIEARRTALKEIEKPSQDDYLRVCDRQTLDLIASFQRAVVNDLVSKALHAAAENNAATLLVTGGVAANSELRETFERRAGELGLPVYFPSRPLSTDNAAMIAAAAYPRFLSGEFAAPDLSAEANLRLR", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.", "AFDB_id": "AF-Q1IUF1-F1-model_v4" }, { "swissprot_id": "P94530", "sequence": "MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSELLRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGLAVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVFFFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWPLIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTVGGVKG", "function": "Part of the ABC transporter complex AraNPQ involved in the uptake of arabinooligosaccharides. Transports alpha-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units. Responsible for the translocation of the substrate across the membrane (Probable).", "AFDB_id": "AF-P94530-F1-model_v4" }, { "swissprot_id": "P33410", "sequence": "MKQIPLILAMSLAFAAAAKGESAPDMQAAVNFDSAMLWGGANGADLSRFNYSNALRPGNYIVDIYANNYPLIRQQVRFVAAQTSGQGLKTAPAVACFTYGQLEAMQVRLRALDPALVADLKSSGRCEVLGKLFPDSRESFDFGENRLEVSIPQAYTINRFRRDISPDEWDSGITAFRLGYQYNYADYIGGLRAGRRLDLNLYSGFNFKGWYLRNSSTLGWGQGRFTRRSQRTSLQTDIPSWRARLVFGDVFSSGEYFAPYSMRGMLVGSDTAMLPYSERLYRPTIRGVARTRANVKVYQAGVLVFQDAVPPGPFAIDDYSPASYGGDLRVVVTEANGAVQTFTVPYASAVRLILPGQTQWSFSAGRYRNYRNDGQDRPWVTQLTGRHGVADGVNLYGGLLIAQAYQAGLAGLSWNTPWGAMAADATLSRSQLSTTGNANGSSLRFSYSKTLSGTNTAIRLATLRYSSSGFWNFADAVNAGPVETNGRNGRFGLYSLLGRERPRGDFSVTLSQPLGGYGSLYVSALRRTYWGSSRVDQQTQLGYSTQVGRVGVNLDVSRTENRRSTEHQVMLNLSIPLYGATSSGVVTGSLARTGSAPVQQSVNYSGMSGERDQYTYGLGVQRAGTSAQYALNGSWSGTYGEVSGQLTHGRSYSQYQINGSGGLVAHAGGVTFGQYQAGTIGLIQAEAAAGAKVVNTRNAAVDRSGYGLVSLTPYSLNEVELSPQDLPLDVQLESTVEQVIPRAGAVVALRFPTRHDVAAMLVAEPGSEGALVFGTEVRDGAGKVVGVAGQGASALVRGVSASGTLEVTRADGSICRATYDLKSAGQAVHGLPRIALACAPQGGGERGARAAGQAVAQPSAISISGKDHEPDIR", "function": "Probable porin-like protein necessary for the assembly of a pilin-type protein.", "AFDB_id": "AF-P33410-F1-model_v4" }, { "swissprot_id": "Q61JS7", "sequence": "MSLSKLSQKCFSRHHARTFIRFSSSDFQSLLGPPRVPNPYADSGRNKFAAPIVPINVNNHGNVFASIKVPINETPEAVAFKPEVEEAPRVEKVEVEATKIETEKVASSPAPATPPSAIDELNSLKDSLSKLEEAAASKTSAPSGSSGDNNDQPGNAEEVEARRKRMERNTRIGGYVLLGGSVIGFISFCFYYGRAQRDEAGNVIADEFSGSFLAPFYRIANSFKLWKDYVVEPAREQLLPDPLPAPYLQPKYTIVIELKNILVHPEWTYKTGYRFLKRPALDYFLDVIGYPNFEVVIYSSESMMTAAPVVDSFDQKQRIMYKLFRDCTKYMNGHHVKDLSKLNRDLSKVIYIDFDAKSGQLNPENMLRVPEWRGNMDDTSLVDLAELLKTIHLSDAEDVRPMLQYYSQYDDPAKEFRRRAVYLAQQEEQKKQQPDDSSMLKRYSGRLFGFRRHASA", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.", "AFDB_id": "AF-Q61JS7-F1-model_v4" }, { "swissprot_id": "A0A2I6PIZ1", "sequence": "MESSADNTVPKQAESVFIREILENPLMPNLPPELAEIAKFVSFEGNVKPSIPVNWRLAESISALKAFEATFLNYLAHRKYGVRPSNVSINTDHATLFLMSPMLTQIEDRGEVRPFSPFDTLTAELFPNRDKHRANASLQRALITNIYKTKDGRFYHTHGGMNPEPTLQALGLPVEGEVQDTSEVVTDRIQQRLSKYDATHLDHLLNEEHRQAGTIVYSSAEYFASEHGQKNGKVGLYEVIRDPNSSQPAAWWPDHPNAPSSPKRPLAGLKVVDLTRAIAGPTITRSLAEMGASVMRVTSPDITDMSVLHQDLNWGKWNSWLRLDVESDRQKLRDLILDADVVVDSYRPGVMKRFGFGYDEVFNLVRDRSRGIIYVRENCYGWYGPWSHRSGWQQISDACCGISTSYGHAMGLEEPVTPALFNSDYCTGICGSTAVLDALVQRAEKGGSYRVDVSINYYNQWLVRSVGTYDEHTWTDLFRRHDAPVFRHYHSMQYMLPKLLTALYKFDGEILFQREFFGPFRSGALNTTFIQVRPIARFKDDAIELKYNVGTRGNGVDAPTWPADLRREIVRDEDEQGSGFRSGSGLGSGSIAD", "function": "Acetyl-coenzyme A transferase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes nodulisporic acids (NA). Nodulisporic acid A (NAA) and its chemically modified derivatives are of particular significance because of their highly potent insecticidal activity against blood-feeding arthropods and lack of observable adverse effects on mammals, in particular the tremogenicity associated with the paspaline-derived IDTs is not observed. The geranylgeranyl diphosphate (GGPP) synthase ggs1, localized outside of the cluster, is proposed to catalyze the first step in nodulisporic acid biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP). Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase nodC then forms 3-geranylgeranylindole (3-GGI). Epoxidation by the FAD-dependent monooxygenase nodM leads to a single-epoxidized-GGI that is substrate of the terpene cyclase nodB for cyclization to yield emindole SB. The terminal methyl carbon, C28, of emindole SB is then oxidized by the cytochrome P450 monooxygenase nodW to produce nodulisporic acid F (NAF), the pentacyclic core of NAA. NAF is converted to nodulisporic acid E (NAE) via prenylation. This step is probably performed by one of the indole diterpene prenyltransferases nodD1 or nodD2 (Probable). Several oxidation steps performed by the FAD-linked oxidoreductase nodO and one of the cytochrome P450 monooxygenase nodR, nodX or nodZ further convert NAE to nodulisporic acid D (NAD) (Probable). NAD is substrate of cytochrome P450 monooxygenase nodJ to produce the precursor of nodulisporic acid C (NAC), converted to NAC by one of the indole diterpene prenyltransferases nodD1 or nodD2 (Probable). The FAD-dependent monooxygenase nodY2 then oxidizes NAC to nodulisporic acid B (NAB) (Probable). Finally NAB is converted to NAA by one of the cytochrome P450 monooxygenases nodR, nodX or nodZ (Probable).", "AFDB_id": "AF-A0A2I6PIZ1-F1-model_v4" }, { "swissprot_id": "Q9JN69", "sequence": "MDVRTLAVGKAHLEALLATRKMTLEHLQDVRHDATQVYFDGLEHLQNVAQYLAIPLSEFFVGQTQSDLDDGVKIARRNGGFKREEIRGGVHYYTYEHLVTTNQDPGLMALRLDLHSDDEQPLRLNGGHGSREIVYVTRGAVRVRWVGDNDELKEDVLNEGDSIFILPNVPHSFTNHVGGAKSEIIAINYG", "function": "Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.", "AFDB_id": "AF-Q9JN69-F1-model_v4" }, { "swissprot_id": "P0DTF4", "sequence": "MTKNPSSDATLPKGIHRSWKLPDKSLGDLWDSIVMDEAIKKQLLSQAIVNFTVRPKVERTVLPLHGVILLVGPPGTGKTSLARGLAHRVAESFSSAKFRLLEVEPHTLTSSAMGKTQRAVADLFSQSIAESAAAGPTIVLLDEVETLAADRAKLSLEANPVDVHRATDAVLVQLDMLAERNPHLLFVATSNFPQAVDSAFLSRCDMVMEVPLPGKDACKQILVDCLNGLAKTFPGIGKLSSAHQFDVCAGECVGLDGRAIRKVVANALAADPQVAIDPNKLSVEHLRSAIRQAKQMRLQGGKQK", "function": "Prevents the CdnD:Cap7:Cap8 complex (also called CdnD:HORMA2:HORMA3) from synthesizing 2',3',3'-cyclic AMP-AMP-AMP (cAAA). Binds and disassembles an active CdnD:Cap7:Cap8 complex, inhibiting the complex's ability to synthesize cyclic nucleotide second messengers. An AAA+-ATPase remodeler, it is thought that in the absence of foreign threat Cap6 maintains the Cap7 protein in an open, inactive state. Once activated (presumably by a bacteriophage protein) Cap7 binds to and activates its cognate CD-NTase (CdnD in this bacteria) to synthesize cAAA, a cyclic nucleotide second messenger. cAAA activates the NucC endonuclease which degrades all DNA in the infected cell, causing cell death and abortive phage infection (Probable).", "AFDB_id": "AF-P0DTF4-F1-model_v4" }, { "swissprot_id": "P53102", "sequence": "MGPKRQTVSLQEKKNRILNFFQETYTFYNIKELEKSIPKKCGISPMIVKDLVQQMIDEDGVISVEKCGNINIYWCFKNQTLQKLYDSSELIKKKIQEVKCDIATYKQELDKTLATGRRKKFTVGQKSYNREALLEKRKKIQDEIKKKSNSLQKIESIRWDAAKIQENKQQIRLKKVHLEKTTDNIEILIDYLYKKFFLKPEQIRKEFGIPEEFKEFTEV", "function": "Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates DMC1-dependent homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.", "AFDB_id": "AF-P53102-F1-model_v4" }, { "swissprot_id": "Q04344", "sequence": "MEPLISAPYLTTTKMSAPATLDAACIFCKIIKSEIPSFKLIETKYSYAFLDIQPTAEGHALIIPKYHGAKLHDIPDEFLTDAMPIAKRLAKAMKLDTYNVLQNNGKIAHQEVDHVHFHLIPKRDEKSGLIVGWPAQETDFDKLGKLHKELLAKLEGSD", "function": "Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Plays a role in the regulation of kinase KIN28 function. Essential for growth on galactose media at elevated temperatures.", "AFDB_id": "AF-Q04344-F1-model_v4" }, { "swissprot_id": "P54935", "sequence": "MNFPVLKGAGYVLVHTPDMIMHNGTTQTTEKIVNPESEYLKKLPEHLRSFEDVVAYAPNQTYIGSMTPEALGEIAMPWWTEDKKVAGADRYGKLGEIMPQDEFLALMSASDVFDLVLFEKEFIEGAKAKLAAHPVVGNLAESVNAGVELAEIEKQLSEFHAEGLYNNGKLVGCVKRAHDVDVNLNSHTMLENLAVKASGVLALANLIAKNNVNPAEVDYIIECSEEACGDMNQRGGGNFAKALAEMTGCVNATGSDMRGFCAGPTHALIAAAALVKSGVYKNVIIAAGGATAKLGMNGKDHVKKEMPILEDCLGGFAVLVSENDGVNPILRTDLVGRHTVATGSAPQAVIGSLVLSPLKAGGLKITDVDKYSVEMQNPDITKPAGAGDVPEANYKMIAALAVMGKEIERADIAAFVEKHGMVGWAPTQGHIPSGVPYIGFAISDLTEGSVNRTMIVGKGSLFLGRMTNLFDGVSIVAERNTGKVESGSSVSTEEIRKMIAESMKDFAAHLLAE", "function": "In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.", "AFDB_id": "AF-P54935-F1-model_v4" }, { "swissprot_id": "B8N0E7", "sequence": "MRFRQQVETCLNYWPAEGPVQRELILGTVGAYRRPIDSRPVLIQDVRGQEGTFTLDIHGFQFIKHISQHVASFDEASVLKDNMTALEAEHLLKTRWAIVNIWRPLKPVPRDPLAVSDARSFHDKDLLEIYGRVPGRQAKKDYDAATKGSGFGMLYGKYSPGQQWFYMSDMKPDEALLIKCYDSKDDGRTARRTPHTAFVDPRTRDVKVARESLELRCLVFFEDQPLA", "function": "Hydroxylase/desaturase; part of the gene cluster that mediates the biosynthesis of aspergillic acid, a hydroxamic acid-containing pyrazinone with aliphatic side chains that originates from leucine (Leu) and isoleucine (Ile). Aspergillic acid has antibiotic properties and was shown to be lethal to mice. The first step in the pathway is the production of deoxyaspergillic acid via a condensation between the Ile amine and the Leu carboxylic acid, followed by a reductive release from the protein forming the dipeptide aldehyde NH(2)-Leu-Ile-CHO, which could undergo an intermolecular cyclization resulting in a dihydropyrazinone. As the NRPS asaC lacks a condensation domain, it is improbable that it is responsible for condensation of Leu and Ile. One possibility is that asaC acts on a previously condensed dipeptide and functions as a Leu-Ile reductase to yield deoxyaspergillic acid. After asaC forms deoxyaspergillic acid, the cytochrome P450 asaD oxidizes the pyrazinone to the hydroxamic acid-containing bioactive metabolite aspergillic acid. The hydroxylase/desaturase asaB can then convert aspergillic acid to hydroxyaspergillic acid. Both aspergillic acid and hydroxyaspergillic acid can form complexes with iron producing ferriaspergillin analogs.", "AFDB_id": "AF-B8N0E7-F1-model_v4" }, { "swissprot_id": "Q6CN26", "sequence": "MLLYFLVVAPLWMLSGLVRAEVWPSFSDEMIYAIRSQRDLMQNISIDQVPLPGLALKNSLPGSITSNETESLTTILSLLHHGIQSFRVDLTFNSSAGEWFLEGTNIRFVKMLNTVNLFVMATNTNLDANILTILLRFDNDTLRNSNAIKEANFTAILEEGLSPGYVYSIADLERDRELNQTLSINGYSDTGWVGLSRFLFDVKKRVVFGFLNGAELFSEDDQDNLVFPPETFHYVTANNITCPLNTVEDIMRVSQIQWRFLEGNFSYENYLHYLECGYSLILTNPIDTRNDSSQGTSLQRHLSSLLLWSWNATAPDDKLDESEDSDDSESSSTSQYVAYRCGAFSYNDYEDLDPFKIGNCYRNLPYLCRFSDRAYFWNISEDTGTYFESDDKDMCPTGYKFGVPRTPLQQRSLRIHLNDMDIDNLDFWIDINSISVSNCWITGGPYASCPYQKYGSRRNYIAMTVPTSAIALVLLLVIFYFNWVHVPIQDNRNNWKRIINAYSKEEVEGVPS", "function": "May be involved in telomere capping.", "AFDB_id": "AF-Q6CN26-F1-model_v4" }, { "swissprot_id": "Q9UT48", "sequence": "MSDTTSLNVPELESPPIERVELESLLVMNIIKHCRDSFPNMGTIGQLVGIDIDGVLQVSSSFESPSVLENEESAVNKSVSGKARQAHTEAMLNRLQYIGAVTGHVGWYLGAYVSSFLSSPFFVETQYAYQKANPNSIAFLYDLSQSSNGTLYMRAYQLTPEFMAAHEEKTWTASSLNSHNLTPSNVIRELPIVIHNSHLATCLLHSLSEPPTPASTLTAEAALEDCESNLPLTETFSNFEVSLGTRYRKNIELLLESTDEFHYEQGNLGFHQRQLAREQAKIQQWIAKRKAENANRAAENLQPLPLDDWKRIFKLPAEPRLLDSLLISSQIMKSTQIDEQSSAFLSKLAGVRNAYAS", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.", "AFDB_id": "AF-Q9UT48-F1-model_v4" }, { "swissprot_id": "Q58065", "sequence": "MRAIIIGSGAAGLTTASTIRKYNKDMEIVVITKEKEIAYSPCAIPYVIEGAIKSFDDIIMHTPEDYKRERNIDILTETTVIDVDSKNNKIKCVDKDGNEFEMNYDYLVLATGAEPFIPPIEGKDLDGVFKVRTIEDGRAILKYIEENGCKKVAVVGAGAIGLEMAYGLKCRGLDVLVVEMAPQVLPRFLDPDMAEIVQKYLEKEGIKVMLSKPLEKIVGKEKVEAVYVDGKLYDVDMVIMATGVRPNIELAKKAGCKIGKFAIEVNEKMQTSIPNIYAVGDCVEVIDFITGEKTLSPFGTAAVRQGKVAGKNIAGVEAKFYPVLNSAVSKIGDLEIGGTGLTAFSANLKRIPIVIGRAKALTRARYYPGGKEIEIKMIFNEDGKVVGCQIVGGERVAERIDAMSIAIFKKVSAEELANMEFCYAPPVSMVHEPLSLAAEDALKKLSNK", "function": "Catalyzes the four-electron reduction of molecular oxygen to water.", "AFDB_id": "AF-Q58065-F1-model_v4" }, { "swissprot_id": "A8XJ44", "sequence": "MPRICVLGAGIMGVSTALAIQERIPDSVVTIIAEKFSPNTTSDVAAGLIEPYLCDDDVDRVISWTKSTIQRIQEYMNEGNPGAESQEQSGYWLQSVKSVPKWLEVMKNVKILTGNELKMVAKRPEHKFGIFYTTWYLEPTPYIKWESDKFLKNGGKIKNSKIQKIEDVEKEFGLFDVILNCTGIGARHLIGDNEVFPTRGQILKVKCPSVKHFFIDDQFYALLNDTTITLGGTADRHQWDRTINPKISEKIFQENCKNIPSLRSAQVISSHVDLRPSRVTVRLEAEPDSKVIHNNGHGGSGITLHWGCALECVELVKKVLAGKPGISKI", "function": "Catalyzes oxidative deamination of D-amino acids, in particular D-alanine, and could be responsible for the degradation of diet-derived D-alanine in the intestine. Acts on a variety of D-amino acids with greater preference towards those with basic and aromatic groups followed by those bearing neutral groups. Has no activity against acidic D-amino acids, L-amino acids or N-methyl-L-aspartic acid. May play a role in egg-laying events and early development.", "AFDB_id": "AF-A8XJ44-F1-model_v4" }, { "swissprot_id": "P50598", "sequence": "MEPNVVDHTSMWSLISNASIVVQLVMLTLVAASVTSWIMIFQRGNAMRAAKKALDAFEERFWSGIDLSKLYRQAGSNPDPDSGVEQIFRAGFKEFSRLRQQPGVDPDAVMEGVARAMRVAISREEEKLEASLPFLATVGSTSPYVGLFGTVWGIMNSFRGLATVQQATLATVAPGIAEALIATAIGLFAAIPAVIAYNRFSARSEMLIGRYYTFADEFQAILHRKVHTSDD", "function": "Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.", "AFDB_id": "AF-P50598-F1-model_v4" }, { "swissprot_id": "P38776", "sequence": "MVAEFQIASAQSSALTSTEEEHCSINSDKAAKLDLELTSERKNDGKQSHEVTFNEDIADPEDIARHMSTARRYYISSLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQSYKWTFITLLITSGCCLVMIIFTIPETYKPMLLIRKAKRLRKEKNDQRYYAVLEVTREQTSLLSAIFLSTKRPFGLLLRDRMMGVLCFYTGLELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTCLLFQKTFEWRVKRNNGVKTPEMRFEPLFYGAFLTPVGLFIFAFTCYKHVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGMACNTFVRCIMAGVFPLFGLQMYKSMGVNWAGFLLAMVTVAMIPVPFLFTKYGARLRAKSPYAWDD", "function": "Probable drug/proton antiporter.", "AFDB_id": "AF-P38776-F1-model_v4" }, { "swissprot_id": "B8PL20", "sequence": "MGNAYIFSLQPTFTQGLILGQFSILFLLVLVLKYLFFDTVSDHAYRTSSYQPKIERDEDEDGIALVAERLAPKPAQDGKQSGNECESADWLNALLIQVLEAYRVKLRDGLPGAEGDEVARKRVERFANQMRPPGFLDPIKVHSVDLGVTAPRLSRARPRPQKAPNTDPAIEFDMSYADTISLSLSTSVLFNYPFASFARLPVSLTISLSHFSSSVLLTPPQPHAQHPTVTLNLPSPGTDFVLNIQTKSLMGSRAKLADVPKLHEMITHQIQRVLLEKGTWKVVLPGLASVSEVKEDVKREQQAGELPVN", "function": "Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.", "AFDB_id": "AF-B8PL20-F1-model_v4" }, { "swissprot_id": "Q59039", "sequence": "MIREIFNSIMGEGKYIGRRFIFVRFAGCPLNCVYCDEESKGYFNRVEKIPGSGEFETLQKMEIEDIINAIDKLKTPDLFAVSFTGGEPLLYHKQIKEIAEILKDKGYRTFLESNGMFPERIFYFDIASIDIKLKEHFEYIKDEDYEKLYKNELKTIKKLYNLNSDIYAKVVIMEETNIEDVKIIAKDLSDIGNITLCIQPVTPHGNIKSPSQRKLFEIMEACGEYLKDNVMLTIQMHKYLGML", "function": "Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.", "AFDB_id": "AF-Q59039-F1-model_v4" }, { "swissprot_id": "Q1Q8Y4", "sequence": "MSKKKGFWSSLFGTDDSNAGSANMATERLKVIVASENRLNNRLTADRIEKMKREILEVVNKYVNGVQIDDVNINHRSEDSLDVLEMNINLPEHKK", "function": "Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.", "AFDB_id": "AF-Q1Q8Y4-F1-model_v4" }, { "swissprot_id": "Q8U671", "sequence": "MKEHRHMTEKSPHSAFGDGAKAYDVPAFGLQIHTVEHGSGAPIVFLHGNPTSSYLWRHIFRRLHGHGRLLAVDLIGYGQSSKPDIEYTLENQQRYVDAWFDALDLRNVTLVLQDYGAAFGLNWASRNPDRVRAVAFFEPVLRNIDSVDLSPEFVTRRAKLRQPGEGEIFVQQENRFLTELFPWFFLTPLAPEDLRQYQTPFPTPHSRKAILAGPRNLPVDGEPASTVAFLEQAVNWLNTSDTPKLLLTFKPGFLLTDAILKWSQVTIRNLEIEAAGAGIHFVQEEQPETIARLLDAWLTRIAGN", "function": "Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.", "AFDB_id": "AF-Q8U671-F1-model_v4" }, { "swissprot_id": "A1ZA92", "sequence": "MLDEHILKEMKLSFQLTEQRELASGRRKPEKPQHPPAVPKKKVISKVASNPAKISETMIQKAQMESPKKSKKNKTAGAKRPLSNNVSNPDSSPSQKRLKKDNTLPKKNPVNKSSNVAAKKSAATSKSAKLPIPKVHSINELAPKKTKVKTPNKTKEASLSKKHKVNGNKSSMKVVQNGKVVEIIGTAAETSDIEMNSLDDWSEEDDYLIESDSENDVVEEIDETFLKDPKIFKVKCKGPEYKLSDILPPFEHDEYQPLLLDGDGSGTVRKIKVFKSAQEETDSDEDDIDYEPEDSDDFGSEEFDSEESDSEDTSSADYDSDGDFYSEYSDMEDVSDSDSEEFGSDIFDTDDLDSTYEPPDIEGFFDHPPVGMQREPLIIEEIFDDPPVEKKQERIEQSSVMDIVVKNLSSVPPKKESEVAIETEENDEVSLPEVVTPEKENYLQPSDVPFYRNPQANPTELSVFENSLKSNHVLAVIKEDLEVYGTLVLTLLCGQISVNGYRARRQEAITIYSPKGLNWVSISPTKTKKPVKDEVNWEELNKNFTRAQLDRIKTSFQRQTNAIVLLHRNTSAQQLVDTFGKHMAQNVFPLVNSSNRPFGQSETLLHCLIQSSDQSRTLQVPQVWNKLQMHATSRIIVAGGKGVGKSSLLRYLINRNLGQFPSMLLIDLDIGQPEIFVPQTISCTVIDEPLLGPGFLYNRQPEHAIVVGHTNIVLCAEQYARAVIQLVQNIQNDAKYSNIPWLINTMGYNKGFGIELMALLVDRIRPTDLVQIASPIPINNFDSVLDRNSLSQIKPIIYSAEEFKINEIPKYTLHKLISAVPAREKGTWSLSAKDMRYSNLLARLSSCLTGNAKSLTDCQPLGVSLESLKILHPTSKNYSREELIRGMEANVVYLCHHGAGLPQCLGIGVVRAIDYERKELYLVPAMPLQKMSLVDCLILGGEQSLPQGFLRDQGQGVSSSVPFVFILDDSKSSKSIQQIYHRAPAFLGVPANQRN", "function": "Polynucleotide 5'-kinase involved in rRNA processing.", "AFDB_id": "AF-A1ZA92-F1-model_v4" }, { "swissprot_id": "Q0P9C5", "sequence": "MMKISFIIATLNSGGAERALVTLANALCKEHEVSIIKFHAGESFYKLENEVKVTSLEQFRFDTLYHKIASRFKKFFALRKALKESKSDVFISFLDTTNIACIAAKIGLKTPLIISEHSNEAYLKPKIWRFLRRVSYPFCDALSVLGSSDKVYYERFVKRVKLLLNPCHFSDEISFDSSFEKENLVLFIGRLDHNKNPVMFLKAIAHLDKNLQENYKFVIAGDGQLRQELEYKVKSLGIKVDFLGRVENVKALYEKAKVLCLCSFVEGLPTVLIESLYFEVCRISSSYYNGAKDLIKDNHDGLLVGCDDEIALAKKLELVLNDENFRKELVNNAKQRCKDFEISHIKEEWLKLIAEVKNA", "function": "Processive glycosyltransferase that is part of the biosynthetic pathway of the lipid-linked oligosaccharide (LLO) that serves as the glycan donor in bacterial protein N-glycosylation. Catalyzes the transfer of exactly three alpha-(1->4)-N-acetylgalactosamine (GalNAc) units to the growing LLO precursor, GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenyl. Cannot accept UDP-GlcNAc as substrate.", "AFDB_id": "AF-Q0P9C5-F1-model_v4" }, { "swissprot_id": "Q7WTJ2", "sequence": "MSYQVTIEPIGTTIEVEEDQTILDAALRQGVWLPFACGHGTCGTCKVQVTDGFYDVGEASPFALMDIERDENKVLACCCKPQSDMVIEADVDEDPDFLGHLVQDYQATVIEIKDLSPTIKGIRLQLDRPIEFQAGQYINVQFPNIEGTRAFSIANSPSEVGIVELHIRKVEGGAATTYVHEQLATGDQLDISGPYGQFFVRKSDDQNAIFIAGGSGLSSPQSMILDLLESGDSRTIYLFQGARDLAELYNRELFEQLVKDYPNFRYIPALNAPKPEDQWTGFTGFVHEAVADYFENRCGGHKAYLCGPPIMIDSAISTLMQSRLFERDIHTERFLSAADGAAGQSRSALFKHI", "function": "Probable electron transfer from NADPH, via FAD and the 2Fe-2S center, to the oxygenase activity site of the enzyme.", "AFDB_id": "AF-Q7WTJ2-F1-model_v4" }, { "swissprot_id": "Q18891", "sequence": "MAPGTAELEIDETLHLLRMVMQREFIHYLETLPGTKELFIDKCLLRPLDMIATSSDMKRHGVKRIMHFDLQKSPQVWNIEIDQRVFFLRPNVENARKIVEYVEESSENRSICVIWCNRQLEECDLAFESSGVIGHITQLSLNMCLLPLESDLFSLQHVESAQPDLFSVANMFVALQNLYGVIPTVYGLGSESKNLWNLVHALCSSNELRARPDQPISHLFLFDRQLDPVPVLLTGASYEGLLHEFFTIDCGKLAFPVDLRKQVQTGPLDFDWIEINPEEDKEAHQQNRGDTVKLDNCEDIFASIRNKHVTAALEFLHSKAKSIQKSIEKSSMIDDVADYRNFVEKDLRALKKDHKHCELHINACEMMMNKVKMEDYRTMFKLEHEMLLGTVTHEEYFDFVFERVPMRSCRDVVLSMMSLASLKLDGVPDDTYNEFVEMYLQKYGYEHMFELQNLRNSRVIYARRHIAHDRTISERARTWETLARKFRIVKGNEPMDMSNPSDMSYVFGARISPLLCKIVEDTIDHGWNQAEYERIIGKDKVLVEENTYIAADRRPDNRTRKAIMVFVNGGITYWEVAALRLLAIQKNFRILICTTHVIKKREYLEVRAKDASSVFGS", "function": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Most likely within the CORVET complex, it is involved in the fusion of endocytic compartments. Required for sperm development and function.", "AFDB_id": "AF-Q18891-F1-model_v4" }, { "swissprot_id": "Q09553", "sequence": "MRRVILPLVMTVTLCLAQEASEACTKALTDCENDLECQNRLAPLMAACSTNTCQPQCRSAVLNVYQNKLGRILLRSDATCIPGRDELRTCNFLPAESTVHCSLGKLACEGDLQCNSKFGVFMSECEADAARGACTDKCKTLLNQTIETSVGSVFSNCTCTARDDQLCTNLKDNLLGVCLKNTPGVTLSPSDNSITDAPGGNDLADSSVGHGFNILSAISVYLLTVLVF", "function": "Role in pharynx function or development.", "AFDB_id": "AF-Q09553-F1-model_v4" }, { "swissprot_id": "O04133", "sequence": "MTMEYRTLELNIISAKDIKNVNLFSKMDVYAAVSLSGDPLHPQGATTHVHKDAGSNPTWNYPVKFSVNESLAKENRLSLEIKLISDRTLGDTVIGTVHVPLRELLDNPGDDSSFRQVSYQVMKQSRKSKGSLNFSYKFGEHVPAPAAKTPKAAKAGQEPVMAYPPAGAGSSSMPYGTPHPPPPQQYAATGYGYPPQQVHGGYPPQAAYGYPPQTGYGYPQQSGYGYPQQSGYGYPPQAQKPKKNKFGMGLGAGLLGGALGGMLIGDMVSDAAEYDAGYDAGFDDAGGFDF", "function": "May play a role in cold responses.", "AFDB_id": "AF-O04133-F1-model_v4" }, { "swissprot_id": "Q95QG8", "sequence": "MDIKFEGNDAECTAGLKKASEGSFVLKDHVLIEFKINGKVAGKIKTPCEGVVTFGKGLKPGIVLNKGQVIATVSECTHAIVIKDMCATCGKDLREKGGRAGQRKEQSTANVSMIHHVPELIVSDTLAKEIGSADENNLITNRKLVLLVDLDQTIIHTSDKPMTVDTENHKDITKYNLHSRVYTTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDARLFEQRILSRDELFSAQHKTNNLKALFPCGDNLVVIIDDRSDVWMYSEALIQIKPYRFFKEVGDINAPKNSKEQMPVQIEDDAHEDKVLEEIERVLTNIHDKYYEKHDLRGSEEVLLDVKEVIKEERHKVLDGCVIVFSGIVPMGEKLERTDIYRLCTQFGAVIVPDVTDDVTHVVGARYGTQKVYQANRLNKFVVTVQWVYACVEKWLKADENLFQLTKESTPPVGRPLGSKYVNDLANMDTIGKAALADMNNEVDEALSDDEDDGDNEDEDDDGNDVGEDKGDENLEEKQEKNEEEMDDVEQNGSVENQSGDALENETDSTSRGQKRKHCPEMEDEEEESDSDNEDDDTPMSYKALLSDSRKKGRIVPENEDDAVFDVDDEKGHAPANIDEEEDDEDNEDEEVPESDDDDEFEDMAALIERQISDAVDEKDQ", "function": "During the late stages of oogenesis, dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit ama-1. Similarly, dephosphorylates 'Ser-5' of ama-1 in early embryonic cells prior to the activation of the zygotic transcription program at the 4-cell embryonic stage. May dephosphorylate 'Ser-2' of the ama-1 heptad repeats YSPTSPS in embryonic somatic and germline cells.", "AFDB_id": "AF-Q95QG8-F1-model_v4" }, { "swissprot_id": "C5E4H7", "sequence": "MNISPTPRRYNSRNGGIDFNDENYLAFSDPVNRDANGNGIGRERIVPEEYKLNSRMINRLIRQNKELMNKLDGKQEEIDRLNVLVGSLRGKLIKYTELNKKLEDRQNVSRSSSGGSNGMETDSNYIQLPKRRNNKDLDKDTDPRLSKDDRISVLSEKLDMLTKIMMESRNSSLASPPPQQQQTANIPTPASAPTAATSSTSPLPPNTSTSVWQRPSEEDIMCRESMELKQLEDQIESLKRKLLIKRENELRKISLSQELLELMGKLSMEQAQVQQGAAGSTATTVPPRTSTAVPSAEQHVSSSSPEFCMECHHTKTHPLHQHHDHNHILRNDLNSRRPTVPAINPLETPTPFAKRASLAASTGDLTDTINRVW", "function": "Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.", "AFDB_id": "AF-C5E4H7-F1-model_v4" }, { "swissprot_id": "P9WHM4", "sequence": "MQEPLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAVGVDRECRAAEIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRILGPQFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILAQQPVPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRTATMGRKVTIG", "function": "Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.", "AFDB_id": "AF-P9WHM4-F1-model_v4" }, { "swissprot_id": "B3STP1", "sequence": "MIKGLIYLFLFRCLEGRLADYEEESSDLGDYSLNGQTDEEYGKFPSHVLTEKETGPMDEIRCTNDDYTYNIKLNVHLQNYAIQAIADAAKPKLGMNLKERDAILSYFGTIANELNADLARLGAQIVIGLKHYKAEDFIDTNSFDTSCEIRDPVMDRLDSTFKQLKDVYQDSMGLRLFVWTCPQLTSSFETMKIMSNLNCGRIMGVLWQGADATRTSIKSTILEAISGVSELYLDGALPVDRVFSNVCRFCSKCVGVEPGVIGWKHPDVVKLIHAIPEEDTHEHGYDH", "function": "Involved in adherence of spores to the host cell surface and in infection efficiency.", "AFDB_id": "AF-B3STP1-F1-model_v4" }, { "swissprot_id": "A5H0J2", "sequence": "MSVDTLGWSAQDWIDFHGKSTPEHSYNTLLSLLKSQKSAPEDPAWISLINEANLAHQWKVLQSKANKQQLPLYGVPIAVKDNIDSKGSPTTAACPAFEYNPSADSTVVALLKDAGAIVIGKTNLDQFATGLVGTRSPYGKTPCVFSDKHVSGGSSAGSASAVGRGIVPIALGTDTAGSGRVPAALNNLIGLKPTKGLFSCSGVVPACKSLDCVSVFAMNLSDAERCFKVMAKPDLENDEYSRPLPSNPLQKYPKNVTIAIPKEVPWYGETENPKLYAKAIENLKVAGASIVTIDFEPLLALARCLYEGAWVAERYEATKDFFATNPPESSLDPTVTSIIKTATKYDAADSFRYEYQRQGILQKVDQTLKDIDVLCVPTCPLNPTFEEVAAEPVLVNSRQGTWTNFVNLADMAALAVPAGFRPDGLPQGVTLIGKKFTDFALLELANRYFKVAFPQGSRTFGKFIDRQVTTKDDELRGPDISPEDSVKLAVVGAHLKGLPLYWQLEKVNATYLGSPKTSKNYKLYALPKTGPILKPGLRRVGEETGSQIQLEVYSVPKENFGEFISMVPEPLGIGSVELESGEWVKSFICEEFGYTQKGTVDITKYGGFKKYIDFLKQEEAKVKKPFETVLIANRGEIAVRIIKTLKKLNIRSVAVYSDPDKYSQHVIDADLGVALNGRTAAETYLDIDKIIKAAKDTNAQAIIPGYGFLSENAEFADKCVEEGIVFVGPSGEAIRKLGLKHSAREIAEKAGVPLVPGSGLVTSAKEAKEIANKLEYPVMVKSTAGGGGIGLQKVDSENEIERVFETVQHQGKAYFGDSGVFLERFVENARHVEIQMMGDGYGKAIAIGERDCSLQRRNQKIIEETPAPNLGETTRTKMRQAAESLGSLLKYKCAGTVEFIYDERRDEFYFLEVNARLQVEHPITEMVTGLDLVEWMLRIAADDAPDFESANIVVTGASIEARLYAENPAKDFRPSPGLLTDVHFPEWARVDTWVSKGTTVSAEYDPTLAKIIVHGKDRNDAIMKMNKALNETVVYGCITNIDYLRSIASSEMFKTAKVATKILDSYDYKPCAFEVTSPGAYTTVQDYPGRVGYWRIGVPPSGPMDAYSFRLANRIVGNHYKAPAIELTLNGPKILFHTETIIAISGGIAACSLNDKPIEQNKPIQVNRGDHLAIGKLSVGCRAYLAIRGGIDVPEYLGSRSTFALGNMGGYNGRVLKLGDVLFLNQPELASSSLPGPAYEPQAPPANLLPKISDDKEWTIGVTCGPHGSPDFFKPESVEEFFSEKWKVHYNSNRFGVRLIGPKPKWARKDGGEGGLHPSNAHDYVYSLGAINFTGDEPVIITSDGPSLGGFVCQAVVPEAELWKVGQVKPGDSIQFVPISYQVARQLKESQDAAIETLEDGKLQTLTSDLILPTYEDPVLVQLPKKSNLSPKVTYRQAGDRYILVEYGENQMDLNIAYRINQLINLVGKHKTVGIVEMSQGVRSVLIEYDGYKISQGALLDTLVAYESEIQFDKNWSIKSKIFKLPLAFEDSKTLECVTRYQETIRSKAPWLPNNVDFVAEVNDITHKDVENMLYSARFLVLGLGDVFLGAPCAVPLDPRHRFLGSKYNPSRTYTKNGVVGIGGMYMCIYAMDSPGGYQLVGRTIPIWDKLKLGSHSQEHPWLLTPFDQVEFYPVSEEELDRFTEDCENGKFPVQVEESVFDHKNYLKWINENIESITEFQKSQGGAKADEFARLIQVANQELESSTTNKSAVEEEYPEDAEMVYSEYSGRFWKPMVSAGDTVTKGDGLVIVEAMKTEMVVPAKKSGKVLKIVHKNGDMVDAGDLVAVIQ", "function": "Involved in uracil catabolism. Hydrolysis of urea to ammonia and CO(2).", "AFDB_id": "AF-A5H0J2-F1-model_v4" }, { "swissprot_id": "Q62767", "sequence": "MVTMEELREMDCSVLKRLMNRDENGGTAGSSGGSHGALGLLSGGKCLLLDCRPFLAHSAGYIRGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSTNESLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLTTSCAAEAASPSGPLRERGKATPTPTSQFVFSFPVSVGVHAAPSNLPYLHSPITTSPSC", "function": "Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.", "AFDB_id": "AF-Q62767-F1-model_v4" }, { "swissprot_id": "P39639", "sequence": "MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPHTNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVIAIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMPFHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIFFPPRYNRAKAKKMKADE", "function": "Part of the bacABCDEF operon responsible for the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase. BacB catalyzes the allylic isomerization of the endocyclic-delta(4),delta(8)-7R-dihydro-hydroxyphenylpyruvate (en-H2HPP) to generate a mixture of 3E,7R- and 3Z, 7R-olefins (E/Z ration of 3/1) of the exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP).", "AFDB_id": "AF-P39639-F1-model_v4" }, { "swissprot_id": "F4K1B1", "sequence": "MAKDNEAIAINDAVHKLQLYMLENTTDQNQLFAARKLMSRSDYEDVVTERAIAKLCGYTLCQRFLPSDVSRRGKYRISLKDHKVYDLQETSKFCSAGCLIDSKTFSGSLQEARTLEFDSVKLNEILDLFGDSLEVKGSLDVNKDLDLSKLMIKENFGVRGEELSLEKWMGPSNAVEGYVPFDRSKSSNDSKATTQSNQEKHEMDFTSTVIMPDVNSVSKLPPQTKQASTVVESVDGKGKTVLKEQTVVPPTKKVSRFRREKEKEKKTFGVDGMGCAQEKTTVLPRKILSFCNEIEKDFKNFGFDEMGLASSAMMSDGYGVEYSVSKQPQCSMEDSLSCKLKGDLQTLDGKNTLSGSSSGSNTKGSKTKPEKSRKKIISVEYHANSYEDGEEILAAESYERHKAQDVCSSSEIVTKSCLKISGSKKLSRSVTWADQNDGRGDLCEVRNNDNAAGPSLSSNDIEDVNSLSRLALAEALATALSQAAEAVSSGNSDASDATAKAGIILLPSTHQLDEEVTEEHSEEEMTEEEPTLLKWPNKPGIPDSDLFDRDQSWFDGPPEGFNLTLSNFAVMWDSLFGWVSSSSLAYIYGKEESAHEEFLLVNGKEYPRRIIMVDGLSSEIKQTIAGCLARALPRVVTHLRLPIAISELEKGLGSLLETMSLTGAVPSFRVKEWLVIVLLFLDALSVSRIPRIAPYISNRDKILEGSGIGNEEYETMKDILLPLGRVPQFATRSGA", "function": "Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.", "AFDB_id": "AF-F4K1B1-F1-model_v4" }, { "swissprot_id": "Q9WZP2", "sequence": "MEFLKRSFAPLTEKQWQEIDNRAREIFKTQLYGRKFVDVEGPYGWEYAAHPLGEVEVLSDENEVVKWGLRKSLPLIELRATFTLDLWELDNLERGKPNVDLSSLEETVRKVAEFEDEVIFRGCEKSGVKGLLSFEERKIECGSTPKDLLEAIVRALSIFSKDGIEGPYTLVINTDRWINFLKEEAGHYPLEKRVEECLRGGKIITTPRIEDALVVSERGGDFKLILGQDLSIGYEDREKDAVRLFITETFTFQVVNPEALILLKF", "function": "Protease that exhibits activity toward chymotrypsin and trypsin substrates. Probably does not have antibacterial activity (Probable).", "AFDB_id": "AF-Q9WZP2-F1-model_v4" }, { "swissprot_id": "A0A0D1CFF0", "sequence": "MATEHILLVCWPAVGHARPMLDYAAAQLKQNPGLIITFICSKMQIALLEGLAISEHLADKKFGDRLRLLGTGRPAQEVLKEFGDREDAKNAANSASKAPNTTANGPEPEVILTMQAATLIQKRFAEIFPTILANDDLFDEQDNSLLLPACVAGKPTTIVVNWMLPGMVETVRKHSSDLKMVTFFDNSCTFVTRMLGPRSIGGFGGIERLWSQYCNSNPEVDPNDSTLKEKLLGRRWTGKFYIPGSRMGAIEEQEMAALAKDWLLSVPLTPSLIEIQKLVDASHTILINTHLAVEERELDYLRMVYPFKKIGILGPAMFSGFVEKGEKLAAKLLDKHINVKPAASRPLTPPETPPPGSPDTDSHGEEEDPKQKSVKQVEKFLAESATGSVVYISFGTMFRPQPTHLIKMLEIIIYEMSLSSQFRLLFTFGGSKDLASSCPPSFAPQISALESQLFKSGNTLFVNWVDQHYVLQHPSVGWFLSHGGWNSCQESMLAGTPLLILPFFGDQLFNAYFLESIQIAYRFNTAANMSVADFVASFREGITCTRPESERGSQLTKNAKELQLRLKGERALAEVRLF", "function": "Glycosyltransferase; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA). UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U.maydis. UA consists of 15,16-dihydroxypalmitic or 2,15,16-trihydroxypalmitic acid, which is O-glycosidically linked to cellobiose at its terminal hydroxyl group. In addition, the cellobiose moiety is acetylated and acylated with a short-chain hydroxy fatty acid. UA biosynthesis starts with omega-hydroxylation of palmitic acid catalyzed by the cytochrome P450 monooxygenase cyp1. Terminal hydroxylation of palmitic acid precedes subterminal hydroxylation catalyzed by the cytochrome P450 monooxygenase cyp2. Sequential glucosylation of the hydroxy fatty acid is probably catalyzed by the glycosyltransferase ugt1 (Probable). The cellobiose lipid is further decorated by acetylation of the proximal glucose residue and by acylation with a short-chain beta-hydroxy fatty acid at the distal glucose residue (Probable). The acyltransferase uat1 may be a good candidate for catalyzing either acetylation or acylation of the cellobiose lipid (Probable). The fatty acid synthase fas2 may be involved in synthesis of the carbon backbone of the short-chain beta-hydroxy fatty acid esterified to the cellobiose disaccharide (Probable). The secreted UA consists of a mixture of both alpha-hydroxylated and non-hydroxylated glycolipids; therefore, alpha-hydroxylation of the long-chain fatty, catalyzed by the fatty acid hydroxylase ahd1, occurs late in UA biosynthesis and may be the last step before secretion.", "AFDB_id": "AF-A0A0D1CFF0-F1-model_v4" }, { "swissprot_id": "Q9YBR6", "sequence": "MSGSVLDEEAEKLMDYDYLLEKLYKKVPPKSGTSEYRIPEPQIIRIGSQTVIRNFREIAQALKRDPKLVARYLQKELATAASYEEESGQLILNVKVSRKVVNQFLQLFMKTYVRCPTCGSIDTKLLRQERAYMLKCEACGAEQPVKPI", "function": "eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.", "AFDB_id": "AF-Q9YBR6-F1-model_v4" }, { "swissprot_id": "A3DDM2", "sequence": "MLKIGIIPNEDKDEELKYTRILVDSIKKCGGTAIVCDDIALKLGDKESNINEDNIVDMSDVMVCLGGDGTFLKAARMTVVKGKPLLGVNLGKLGFLADVDKNDIENAVKRLVEDKFTVDERMMLDTVIVRDGKIIAEDIVLNDVVISRGAISRILHLKTYINDAFMDLYPGDGLIISTPTGSTAYSLSAGGPLVEPDVDLIICTPICPHLLYSRSFITTADRVIKVVVAESSSHEAMVTVDGQNGYEVRGGDVIITKKSRIRMPMVRLNGKNFFDVLRGKIYDRGESMK", "function": "Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.", "AFDB_id": "AF-A3DDM2-F1-model_v4" }, { "swissprot_id": "A6LPA6", "sequence": "MNVAVILFGGKGERFSKDYPKQFVKFHGKTLMEHTVEKFLENFIHLIIIVVNGEYLEESKKILKKYKRKNIYVILGGKTREFSTLNAVKYLKDLISEDDNVIIHDGARPFVSKEVILRNIDFVNKYGAVVTAVPVENTIAFVENKIVKEIPPRRYLFTLQTPQTFKYSILYKSFRLIKDLEKFTDDSSVVLAAGYNVHVVYGEKTNIKITTKEDLYLIGVEKIEGNI", "function": "Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).", "AFDB_id": "AF-A6LPA6-F1-model_v4" }, { "swissprot_id": "D7UNT2", "sequence": "MSFITKAACVGGGVIGGAWVARFALAGIDVKIFDPHPEAERIIGEVMANAERAYAMLTMAPLPPKGKLTFCKSIEEAVEGADWIQESVPERLELKRGVITKIDAAARPDALIGSSTSGLLPSDLQSEMHHPERMFVAHPYNPVYLLPLVELVGGKKTSKATIERAMQGVEQIGMKGVVIAKEIEAFVGDRLLEALWREALWLIQDDICHTETLDNVMRYSFGMRWAQMGLFETYRIAGGEAGMRHFLAQFGPCLKWPWTKFTDVVDLDDALVEKIGAQSDAQAAGRSIRELERIRDENLVGIMHALKSGNGGEGWGAGKLLADFEAKLWANARKPEADLGDVKPLRILDTKVSAAWVDYNGHMTEHRYLQVFGDTSDGVLRLIGVDLDYVRDGHSYYTVETHIRNLGDEASGEALYSTCQILSSDEKRLHIFSTIYNAATNEAVATAEQMMLHVDSKAGKAVAAPEAVLSKLRAITEAHAQLQTPDGAGRFVGQKRA", "function": "Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine. Despite a high similarity to 3-hydroxyacyl-CoA dehydrogenases, cannot dehydrogenate 3-hydroxybutylate and 3-hydroxybutyl-CoA. Is probably involved in a L-carnitine degradation pathway that allows Rhizobium sp. YS-240 to grow on L-carnitine as the sole source of carbon and nitrogen.", "AFDB_id": "AF-D7UNT2-F1-model_v4" }, { "swissprot_id": "Q5U4U4", "sequence": "MAELLPGYSPSFKKPSEILRLSRRRSRSEASKTGLSPFSPGDVIKRVPGLRPFSPGPNKGAGVKRRNPFASLENTVCSPVKRRAETVAEYGAASLEPRALSAVRPSCLGQDSPEPPQFNSVEDVIWGDPLAADADPLVKTESPEKPAPACEIPKGSVTFPADWSLKTRLLFTSSHSFSWADHLKAQEEAQGLVMQCRATAVNLPHSIQEPKLSTDLRCAFQQSLVHWIHPSLPWVQLFPRIGVDRKMAGKNTPWSQDESLQQVLMSEWALSFTSLYNLLKAKLCPYFYVCTYQFTVLFRAAGLAGSDVITAVMSPTTRGLREAMKNEGITFSQPLVEDDTGKKQKKPEAASQGDINPEKENGTAEADEASDESDEDESFSWLEEMGVEDKIKKPDSISIKLRKEKNEVKLDHKPESVVLVKGTNTFTLLNFLINCKSIVAAAGLQAGLPPTLLSPVAFRGATMHALKARSVNVKTRVNSGYKDQFSLEITGPIMPHSLHSLTMLLQSAQRGSFSAGLYTHEPTAVFNTPIHSQAVKEISADLQNCGLHPCTVEQLTQVNELGKLSLRHLEMTDYRYTWK", "function": "Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.", "AFDB_id": "AF-Q5U4U4-F1-model_v4" }, { "swissprot_id": "Q9FZ99", "sequence": "MEANSADQKQKPNFLVEVNNIEKQLWTLIHSKTILHTDVSELYAKAGSTYEQIFKSNLQHEELQEVEFCLWKLHYKHIDEFRKGLKTNDHAKHMKAFKLFLSKAAEFYQNLISKVRGYYHRLSEESGEQKSRFLCHRFYICLGDLQRYQEQYLKAHEHPNWSTAATYYLEAAKSWPDSGNPHNQLAVLATYVSDELLALYHCVRSLAVKEPFPGASNNLLLLFEKNRSSPLQSLSTDAEFNYLNPSEKKVSVKERDLSKAKGELVAGIDLWPLVVRTTSFFFLKSSFDEFGRAFASTIRELDAAFAADDRNLEAMLESYQFMDTARKGPYKILQIVAVFIYIFHNLAEANGSDIVKEEVKLTNLALTMVFIVMGRVVERCLKTTPLDSCPLLPALLVFLDYLPFLLDKVEEEEEECRFDEKSKSAISYFFGKLVDILNQLKVKDKNCPAKTLLALWEDHELKSLAPLAPIHALLDFSSNMDLRESFDRGKELRLQRIISSAIDITTRQKKGSQKWLFFDNQRTHFYTTSGELQSNGELFHGNGEGRNRKCVTIGPVEIIPLENERSVPVEEEEVILLKPLVRCQSAPIYSSGIAAKPLSSDCTTSGNQTTTSNDSLRRTLSLIGSESFSFTQGLKDTDPQHLHLEEGTVSGRPPSLSAWVVDKNKEKGRLGLSKPNGLGPIDETGPVSAFDSLSINSSTEHPASSYSPPTPSAPLLPEDASWFHNDASTNKAESFYDQTRYMELPGIMKPYTNPPFVGISSSEWLRRYRESRNLGPAYSYQAQGTNNLRNFMAHGSSKFSLLARYGTPNDSSQNSTFHPQLYMEDHESRGEKLGNVQQSTTNPYGFSDDPGPFLRFLREKEWLNENGQRLRGPPPAYMNN", "function": "May play a role in growth and development.", "AFDB_id": "AF-Q9FZ99-F1-model_v4" }, { "swissprot_id": "Q54NA0", "sequence": "MFSLNPQSNGNSNNLFGNVTLGNFSNNSNNLFGGSSTTSTNTNNSNNLFGGSSTTNSNNLFGSGGSSTTNNNNFNSNFNNNNIKNENKIKNGKKFYNFRWSPTGEILLYNTLNNFDNHNFDQKNGGSDTIRYEMNTTLSTIKKFYNDLYTNFETMQRIAGLSNQVIPDDRVREISHHSRTYLSVILAAINQMSKSQKTGSYIDDEDSCMNCDPLDNDLIKIQTPRVLEYFKQYPNKTLIFFCGSIDSIYPYLCSKLSMETKSKCILIARESNVPNSKRLDLIRTISNQGELKILNKDEYSNRYQIANENYGELDDVLTLEIDDTYLAYEREIDNLICMSTMWRVANLFYFSVSSSSNSVSPTQLLDCIELERKELLNSIEQQGTQDPMDSEYYNQIARLLVCGCIDQVIQQLNILSRAPRSASQIKSTSRKSPINLLIDILSSIPLKKKSINGGGGAPLYPNEHLIQWNKWHQETQKILSQYIESGSSSTNQVDENLLPIVKILLGDQQTIMSTCNSFLQLVVSNILFVEYTTSTTQLRQLFTQCYQTIQAPTTVDKIFLSFATKDLDITLKKIFKHSPAWLAVHLSDLLYHHPYVMRKLPNSESQLTNIREYLLSDFGQSLASDSSLLSIGCNYLKYVKNGGLEMIDQFISRQPIHFEKNAIKMLDKWATSVETKNSIYKMLSLQDFKRKRYAASLNWLMLANDNSHITLLSNYLLENQLNSEFLNDLQSLLEKNDEIDCNINNNNNNNNNNNSNNRISGNNNNNMIIDENKFEITNNSELIFLIRYRELISLWKERSFKEYSSSLCLMFKDRVIPKRFWLRLLIDCVPLLESLKNLYFTYQDTLLLQSCLEEIIQSHLFDQYSFNISNQDIQILRSALARNLAKSIIS", "function": "Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.", "AFDB_id": "AF-Q54NA0-F1-model_v4" }, { "swissprot_id": "Q9YBX7", "sequence": "MVDISLIIGGPQGGGIESAGQIAIKSMVLLGYEVLGSREYHSNIMGAHSYYHLRVQQHRPRSLKLPVDGVLALDAESVFTHFRDVRPGGILVYDPGTKSTRVDAIQPMAGPLKKRLKSLFDSRGMQPVVESAVKLAEEAGARIVGLPLKEMLKTLSERTGAPVARVSRALNTLGLASMLYMLGVPVEYIEKAISLQFAGKEKVINMNVEAVRIAVDYVREAFGEPESRLPPGPRRGQTMMVATGNDLVAMGKIVGGLGVITYYPITPSSDEALYVEKHSYISIDGPLAEKLGYDKIAVAIVQMEDELASINAVLGAAAAGARASTTTSGPGFSLMNEAVSLAVEAEIPVVVTLWMRAGPSTGMPTRTGQQDLLHSIFSGHGDAPKIVLASGDHVEAFYDAIKAFNWAEEFQTPVIHLLDKYLASSMVSLAREDLDPSKVPITRGKLLDNPPADYRRYEVVEDGISPRARLGSATMVITGLEHDEYGYATEDPVMREIMMFKRERKFKVIEERIPDEEKAVLHGDSEASVALVSFGSTKQPILEALEMLRDEGVRARFAQVRLLYPFPGRLVEEMLEGVEKVIMVEQNLLGQLAMLLRAHTSIKPDSSIVKINGRPLYSFEVAGAVKRILETGEERVVVSHGS", "function": "Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.", "AFDB_id": "AF-Q9YBX7-F1-model_v4" }, { "swissprot_id": "Q9D9G2", "sequence": "MTMKLVAAALCLSLLAAGLWVGLSLTAESIEEGKPGGEKPGGGKPGGSGRGCFLPPLPKEDVSLCRNLEVFYMEMGNISCKIVPKCNLYRQKITAWQAPIVKFHTALDGALYLLVMVDPDAPSRSNPVMKYWRHWLVSNITGADMKSGSIRGNVLSDYSPPTPPPETGLHRYQFFVYLQGDRDISLSVEEKADLGGWNLDKFLQQYGLRDPDTSTQFMTQFDEELSSEFGRINDDQEQFNQK", "function": "Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.", "AFDB_id": "AF-Q9D9G2-F1-model_v4" }, { "swissprot_id": "Q03388", "sequence": "MSDEGADKSLDTNTEFIIQTRSRRSNAGNKLQKLLEQELRDIESTKRQISSYKNGNDDEEDEIGLLFQEDEDDEDFEMMAKDDDDEGEEKEDETQSIRKEPSQASSEQAADDLMFSSSESEDSSNENDEDAEEKEIRRQELLSRKKRNKRLQKGPVVIKKQKPKPKSGEAIPRSHHTHEQLNAETLLLNTRRTSKRSSVMENTMKVYEKLSKAEKKRKIIQERIRKHKEQESQHMLTQEERLRIAKETEKLNILSLDKFKEQEVWKKENRLALQKRQKQKFQPNETILQFLSTAWLMTPAMELEDRKYWQEQLNKRDKKKKKYPRKPKKNLNLGKQDASDDKKRESEESIKNDGDVNSLGENSSSVHNQKRIEETSTNDTVEGESSPDAAVSRVNSDELKPTALPDVTLDAIANKQSTVDEAPNSQPQKNIITNEQKITNVGEPIQNLHNEEIKDEMVSALESRENTFENSSPAAQVVSQRDNSATPTPSNSTGTEDTILISPDTDIKGEPEPCLKTEGIENLSHNVPQETKSNTDVSFLKQVTFTDHPQVAIIDTEESPSKKDTANVDESSAENSLSTQTYEGPEQLTSRNFVTLYDFPNAPPNLKDFNTNLFGDRWSYTNGLSATQRPQDMKTVFHSILPSPPQSSVPSPTVDISLDLSALANFPSFGEYDKKIVHQINTEINKDLEIKIKTQPPTGVFLANGIRKKCLITNKECQYFDPRTGVPYSDVEAYKIIQRIQDPISKEEGRSDIKRDETTNEDSDDQVRFKWFGFKNGGIYLDLSQRPAKGVPEGF", "function": "Participates in the catalytic exchange of histone H2A for the H2A variant HTZ1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes. Indirectly involved in vacuolar protein sorting.", "AFDB_id": "AF-Q03388-F1-model_v4" }, { "swissprot_id": "Q4A5D8", "sequence": "MEDKKLSSAKPATSSKPAPKAPSTGTKVVTKPASGPRPAFKPGQRKPHASNASNDKVAFEKRNFTSGDKTKKPTDSKNPRFQRNNKDRKFVSEYEEKIVDIARVTKVVKGGRRFSFSAFVVIGNKKGTVGYGHGKANEVPDAIKKAIKDAHNNLVEVPITKGTVPHEVTAKFLASKVLLKSAPKGKGLIASSRVRAVVELAGYTDIVSKTYGSRSAQNVVKSVVKALLNLRTAKQIAEVRDKDVKDLL", "function": "Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.", "AFDB_id": "AF-Q4A5D8-F1-model_v4" }, { "swissprot_id": "P25455", "sequence": "MMSAGGTYISTASVEVPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTGTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDGRTQESRLRSACREYTSQYRELQEKYHEAIYSAAEKVLKTSQTGQTKQLKASLDKVTGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTDELQKQHDSVRNALAEHRSKARQILDKEAESRSCVSSNGFLVLFHGPHHHGCTGSGSSALSGNNLTLNLDAGAAGSHSAISPAKSHNSIAAAAEMKT", "function": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.", "AFDB_id": "AF-P25455-F1-model_v4" }, { "swissprot_id": "Q14CZ7", "sequence": "MALITLRKNLYRLSDFQMHRALAALKNKPLNHVHKVVKERLCPWLCSRQPEPFGVKFHHAHCKKFHSKNGNDLHPLGGPVFSQVSDCDRLEQNVKNEESQMFYRRLSNLTSSEEVLSFISTMETLPDTMAAGALQRICEVEKKDGDQGLPKEILENSIFQALCFQFEKEPSQLSNTSLVTALQALILLHVDPQSSLLLNLVAECQNRLRKGGMEVRNLCILGESLITLHSSGCVTLELIINQLQGEKLETFTPEDIVALYRILQACTEKVDEHQTFLNKINNFSLSIVSNLSPKLISQMLTALVVLDQSQAFPLIIKLGKYVVRHVPHFTNEELRRVLEAFIYFGHHDTFFTKALEHRVAAVCLTLDPEVVCRVMEYCSRELILSKPILNAVAETFVCQTEKFSPRQISALMEPFGKLNYLPPNASALFRKLENVLFTHFNYFPPKSLLKLLHSCSLNECHPVNFLAKIFKPLFLQRLQGKESHLDTLSRAQLTQLFLASVLECPFYKGPKLLPKYQVKSFLTPCCSLETPVDSQLYRYVKIGLTNLLGARLYFAPKVLTPYCYTIDVEIKLDEEGFVLPSTANEDIHKRIALCIDGPKRFCSNSKHLLGKEAIKQRHLQLLGYQVVQIPYHEIGMLKSRRELVEYLQRKLFSQNTVHWLQE", "function": "Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity.", "AFDB_id": "AF-Q14CZ7-F1-model_v4" }, { "swissprot_id": "O09029", "sequence": "MERGLHLGAAAASEDDLFLHKSLGASTAKRLEAAFRSTPPGMDLSLAPPPRERPASSSSSPLGCFEPADPEGAGLLLPPPGGGGGAGGGGGGGGGGGVSVPGLLVGSAGVGGDPNLSSLPAGAALCLKYGESAGRGSVAESSGGEQSPDDDSDGRCELVLRAGGADPRASPGAGGGGTKVVEGCSNAHLHGGAGLPPGGSTGSGGGGSGGGGGGGSSSKKSKEQKALRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQAISAASLPSSAAAAAAAAALHPALGAYEQAAGYPFSAGLPPAASCPEKCALFNSVSSSLCKQCTEKP", "function": "Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA.", "AFDB_id": "AF-O09029-F1-model_v4" }, { "swissprot_id": "Q8BZ47", "sequence": "MSLSSGACGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDASKPTPGTSLFSPSEGAASKKEVQGRAGDGASAGGLVAAVAPKGSEKAAKASRSVAGSKKEKENSSSKGKKERSEGVGTCSEKDPGVLQPVPLGGRGSQYDGSAGMDTGTVEPLGSIAIEPGAALNPLGTKPEPEEGENECRPLKKVKSEKMESPVSTPAVLPLHLLVPVVNNDISSPCEQIMVRTRSVGVNTCDVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGTLLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPSSNTPVSEAAAASDSKGTSSSSKTRAGANSKGRRGSQNSSEHRPPASSTSEDVKASPSSANKRKSKPLSDMELNSSSEDSKGSKRVRTNSMGSATGPLPGTKVEPTLVDRNCPSPVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEEPALHADLSCNGAPVPQKGSLSPARSATPKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDTDPGALSNDGSDDGPSVMDETSNDAFDSLERKCMEKEKCKKPSSLKSEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAASPGSSSGLTTTVVQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKDSSKELESPLTPGKVCRAEEGKSPFRDAAGDGIKVESLLNGSSESHQSRLASIKAEADKIYSFTDNAPSPSIGGSSRLDSTTPTQPLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDGEGKVDSAKSKDPEQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPGYAQSSPGTLTSSSQAGMEGQPLKTKKDEEPESVEGKVKNDVCEEKKPELSNSSQQPSVIQQRPNMYMQSLYYNQYAYVPPYGYSDQSYHSHLLSTNTAYRQQYEEQQKRQSLEQQQQQQRGLDKKTEMGLKEREASLKEEWKQKPSIPPTLTKAPSLTDLVKSGPGKAKEPGTDPAKSVIIPKLDDSSKLPSQPPEGLKGKLGEASHLGKEASEAKTGTECGRQAEVDPILWYRQETESRMWTYVYPAKYSDIKSEDDRWKEERDRKLKEDRSRSKDSVPKEDGKESTSSDCKLPPSEESRLGSKEPRPSVHVPVSSPLTQHQSYIPYMHGYSYSQSYDPNHPSYRGMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARASPSVSCKASSESKALDILQQHASHYKSKSPTISDKNSQERDRGGCGVVGGGGSCGSVAGAGGTDRSADRPRTSPSQRLMSTHHHHHHLGYSLLPAQYNLPYAAGLSSTAIVASQQGSTPSLYPPPRR", "function": "Involved in regulation of myoblast proliferation during myogenesis.", "AFDB_id": "AF-Q8BZ47-F1-model_v4" }, { "swissprot_id": "P44172", "sequence": "MQPNDITFYQRFEADILAGHKTISIRDDSESHFKAGDILRVGRFEDNQYFCNIEVLSVSPITLDELTQPHAKQENMGLDELKEVIRGIYPNEIIFWVIQFSLKEYFNEEKCVREIIITDRKFN", "function": "Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).", "AFDB_id": "AF-P44172-F1-model_v4" }, { "swissprot_id": "Q08351", "sequence": "MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPLHLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLSYWQQP", "function": "Acts as an inhibitor of thrombopoietin signaling by promoting protein down-regulation of full-length isoform Mpl-fl.", "AFDB_id": "AF-Q08351-F1-model_v4" }, { "swissprot_id": "Q20EX1", "sequence": "MNIYLRQNSFLVPDFIAVQRNSFSQFLESGLIQEISKRNPITNSTKELELCFYPQYYKLSPPELNAKQSILKNKTYSCRLYIPVKLTNKRTKTLKLQWVVLGNLPLMTKRGHFIINGSPRVIINQMVRSPGVYFKEVSHADQKLTYYADLIAYRGAWLRIELDKKADIWARMKKTPKLPMLILLQALGLNLPTILKSLNYPKFFENLGHDGNFMKQLKKGRVSSRSSSQELSGSFNLSEDVSLRLDDSSKNMGAENVQRAPLQKSTKKATLFGDFSRSSVYCKTQEEALWALYALTHPLKNPDEVTANLGKSFLYRKFMNSRVYDLSPLGRLRLNQKLNLSVNENITTITAQDLLFITNTLINLNYGVGKVDDIDNLKNRRIRTAGELVQNQFGIGLLRLEKIIREKLKQQQTKLSIGSLINTKPINGALREFFGSSPLSQFMDQTNPLAEITHKRRLSSLGPGGVNRETAGMAIRGIHPTHYGRICPIETPEGQNAGLVNSLTIYSRVNPYGFIETPFYKVVKGQVQNSTRPIFFSAYQEEKKLLAPGDIYANKLKYLPKSELPIRKLAEFTRTTREKIDYISVSPLQMISIATSLIPFLEHDDANRALMGSNMQRQAVPLMTAEAPVVGTGLECRVASDSGHVLQAKKSGFVTYSSAEKITILSPVDSTPAVPKLSKGNNSPQHFHESVGGSCKESQSLQAAAEGYLSGVASSSSSKFTGSSFSTISALNDGVLRRALTQKVLTTGTNCSSMLKNQRFFVEPKAQLYTGAQTPVGRVETILQPNHAEGYLSEVETIQQTQNKLPLQVRFGVEAPKSSFDSEATKISSTLNSIPQHPVLGEDSPSKQVGWALKDPQIQTMLKPKWHHSAQTMSRENWYQNLKGQNVKTFTQVESGRLVTKPTNTKMPMSSLAGTANSKKTGEALYKLASSESATKSMDFSTKTQLKPITYELQKLFRSNQDTSIMHRPVVREGEWVNRGDLLADNSTTVGGELSLGKNLLLAYMPWEGYNFEDAILISERLVSDDAYTSLHIERYEVEIRETKFGLEQITSQIPDEGKLSHLDHFGIAKPGTWVEEGDILIGKVAPMPQKNLSRYEKLLYDVVGKKISTTRDTSLRVPRGVSGRVIHVEILNAENLPPEFVFEGPSRVNLYIAEKRKIHVGDKMAGRHGNKGIISNILPRQDMPYLPDGTPLDMVLNPLGVPSRMNVGQIYECLLGLAGRYLGQKFKVRPFDEIYGPQTSRSLVYSKLYEARLRTGQRWLFNPASPGKTRLFDGRTGECFSQPVTVGQAYMLKLIHLVDEKIHARSIGPYSLVTQQPLRGRSKHGGQRLGEMEVWALEGFGAAYTLQELLTVKSDDIKGREQVMESIQKNKTISLGTPESFKVLIRELQSLCLDVGVYAVDGSGKIKQVDTMKLP", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "AFDB_id": "AF-Q20EX1-F1-model_v4" }, { "swissprot_id": "P25864", "sequence": "MASSTALSLSWSSSPCWSHSFNGGANETLKVSERRFNFEVVSQKKAKKLRKVILKEDVTDLGKQGQLLDVKAGFFRNFLLPTGKAQLMTPLLLKELKMEDERIEAEKQRVKEEAQQLAMVFQTVGAFKVKRKGGKGKLIFGSVTAQDLVDIIKSQLQKDIDKRLVSLPEIRETGEYIAELKLHPDVTARVKINVFAN", "function": "Binds to the 23S rRNA.", "AFDB_id": "AF-P25864-F1-model_v4" }, { "swissprot_id": "Q9HDC9", "sequence": "MSEADGLRQRRPLRPQVVTDDDGQAPEAKDGSSFSGRVFRVTFLMLAVSLTVPLLGAMMLLESPIDPQPLSFKEPPLLLGVLHPNTKLRQAERLFENQLVGPESIAHIGDVMFTGTADGRVVKLENGEIETIARFGSGPCKTRDDEPVCGRPLGIRAGPNGTLFVADAYKGLFEVNPWKREVKLLLSSETPIEGKNMSFVNDLTVTQDGRKIYFTDSSSKWQRRDYLLLVMEGTDDGRLLEYDTVTREVKVLLDQLRFPNGVQLSPAEDFVLVAETTMARIRRVYVSGLMKGGADLFVENMPGFPDNIRPSSSGGYWVGMSTIRPNPGFSMLDFLSERPWIKRMIFKLFSQETVMKFVPRYSLVLELSDSGAFRRSLHDPDGLVATYISEVHEHDGHLYLGSFRSPFLCRLSLQAV", "function": "Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.", "AFDB_id": "AF-Q9HDC9-F1-model_v4" }, { "swissprot_id": "P29849", "sequence": "MLSLQEFVQNRYNKTIAECSNEELYLALLNYSKLASSQKPVNTGKKKVYYISAEFLIGKLLSNNLINLGLYDDVKKELAAAGKDLIEVEEVELEPSLGNGGLGRLAACFIDSIATLGLNGDGVGLNYHFGLFQQVLKNNQQETIPNAWLTEQNWLVRSSRSYQVPFADFTLTSTLYDIDVTGYETATKNRLRLFDLDSVDSSIIKDGINFDKTDIARNLTLFLYPDDSDRQGELLRIFQQYFMVSNGAQLIIDEAIEKGSNLHDLADYAVVQINDTHPSMVIPELIRLLTARGIDLDEAISIVRSMTAYTNHTILAEALEKWPLEFLQEVVPHLVPIIEELDRRVKAEYKDPAVQIIDESGRVHMAHMDIHYGYSVNGVAALHTEILKNSELKAFYDLYPEKFNNKTNGITFRRWLMHANPRLSHYLDEILGDGWHHEADELEKLLSYEDKAVVKEKLESIKAHNKRKLARHLKEHQGVEINPNSIFDIQIKRLHEYKRQQMNALYVIHKYLDIKAGNIPARPITIFFGGKAAPAYTIAQDIIHLILCMSEVIANDPAVAPHLQVVMVENYNVTAASFLIPACDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAELVGEENIYIFGEDSETVIDLYAKAAYKSSEFYAREAIKPLVDFIVSDAVLAAGNKERLERFYNELINKDWFMTLLDLEDYIKVKEQMLADYEDRDAWLDKVIVNISKAGFFSSDRTIAQYNEDIWHLN", "function": "Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.", "AFDB_id": "AF-P29849-F1-model_v4" }, { "swissprot_id": "Q65CX4", "sequence": "MLHGGDYNPDQWLDRPDILADDIKLMKLAHTNTFSVGIFSWSALEPEEGVYTFEWLDDIFESIHRNGGRIILATPSGARPAWLSQKYPEVLRVNAERVKQLHGGRHNHCFTSYVYREKTKEINRMLAERYGSQHALLMWHVSNEYGGECHCDQCQHAFRDWLKKKYNHDIKSLNDAWWTPFWSHTFNDWSQIESPSPIGENAVHGLNLDWRRFVTDQTISFFQNEIVPLKEITPNIPITTNFMADTHDLIPFQGLDYSKFAKHLDVISWDAYPAWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMESTPSAVNWHDFNKAKRPGMHLLSSVQMIAHGSDSILYFQWRKSRGSSEKFHGAVVGHDNCSENRVFKEVAKVGQTLEALSEVTGTIRPADVAILYDWENHWALQDAQGFGMKTKRYPQTLHEHYRAFWERDIPVDVITKEQDFSSYRLLIVPMLYLASEETIARLKAFAANGGTLVMTYISGIVNESDLTYLGGWPKDLQEMFGMEPVETDTLYPGDKNAVRYQNRSYELKDYATVLKLSTADPEGFYEDDFYADTTAVTSHPYKQGKTYYIGARLSSQFHRDFYGTLIKELAIQPALDVKHQPGVSVQVRQDEENDYIFIMNFTEKRQPVVLASAVKDMLTGETLAGEVTLEKYEARIAVKAKE", "function": "Catalyzes the hydrolysis of lactose to its constituent monosaccharides glucose and galactose. Possesses a low level of transgalactosylation activity for the production of galacto-oligosaccharides (GOS) from lactose.", "AFDB_id": "AF-Q65CX4-F1-model_v4" }, { "swissprot_id": "Q557K0", "sequence": "MDKKINLDYLIDDIIVNSDDLTPFQCQICFNSVIDFKKETLSFDVLQCRNGHISCHECWNRQLSIKQECPSCKVKTLPSELSRNIFLENAFRALKVICPNKFKESKFQGEAVHCENGCPEILKVELLEHHLKECQYQFIKCPNNSNKCKYIIRKNQIEHHNQSVCDYSLIQCEKCSELIERKKLNKHIESECDTLMITCSKCSASIGKKLMNHHLETDCPMEEISCLYKAGGCNKRFLRSQLSQHLSENNNHIFYIQNVMDLHKLQLDECNQDYRKLEKQNRDLEKRLFYLESTVNSTVINSKPHECGGGGGGGSGNNVYKGKWVINNWDRKLREYPISKSLNSPFFQIGSSKFFIMLYPNGNNEVKGFLSIFLYKIYDRPSLVKYSLEAKNIDPTKNYKNTHTNNFINNNGNGWFKWIENKSQNGFFSNNSLTISISIKIIQDHSLVTE", "function": "Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.", "AFDB_id": "AF-Q557K0-F1-model_v4" }, { "swissprot_id": "Q26307", "sequence": "MASAMRGEKCERSRIRELVLILSLITMAGDSRATPFDPSFFIEGVQSEVVNPFNRTILNRFNLTEEQILSIQNRSNPNMRDDSAQSSNQQYLQQVATQRLNDIFKRVQKAISNEPNGSASKEKAGFPICNAETTNPEDWSLGNNVTLQFASSVFISNNDDRLSSALLRLYKTNPGQTREHNPGQASTQPISTENPGNTAPNCAEQPPVGPQIRVTVSIVHQQRKKQRKKRTCNTAMLSSSSTGWVEIDVKCALAYWEQQHRQQLRQQQPLQPQLTASVVGILMIEVHDDEENLLRPGLYFAPPTCDQADIAVPWSVYRTEPFKSHLASWTLPRKPRLDIFFNGSNSMKNSYNTPKSRAFIESTTSNSPTIDNQLDESGEYESQQRVHAPLVHHRRHHHNHQQPESESESAQLEAEIEAEELMSSASNSEQQMEPISNHHRHRTGHHHPHHQLHQHHHHHHRHTKHHRIPAHKQE", "function": "Negatively regulates proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis.", "AFDB_id": "AF-Q26307-F1-model_v4" }, { "swissprot_id": "P40526", "sequence": "MYFDEEQLLKYTIYAYRLSFFVGICSLFIAKSCLPEFLQYGKTYRPKENSKYSSILERIKKFTVPKAYFSHFYYLATFLSLVTLYFYPKFPIVWIIFGHSLRRLYETLYVLHYTSNSRMNWSHYLVGIWFYSVLLLILNISLYKNSIPNTLNMNAFIIFCIASWDQYKNHVILANLVKYSLPTGRLFRLVCCPHYLDEIIIYSTLLPYEQEFYLTLVWVITSLTISALETKNYYRHKFKDNHVAPYAIIPFII", "function": "Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.", "AFDB_id": "AF-P40526-F1-model_v4" }, { "swissprot_id": "O95502", "sequence": "MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA", "function": "May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.", "AFDB_id": "AF-O95502-F1-model_v4" }, { "swissprot_id": "Q6FP20", "sequence": "METIHNISNRLQEVLATNKSVNVDTDNDSLSSNQEDNEVEKVRHLVVILGEKYSYAVDRNTGINALMQWFTTNSEIPEEILNAIRSKLNFTYRTNFEPIERAPDGPSPINPLIMLRINPIDAIENVFNNRECFFTDVGWGCMIRTGQSLLGNALQRVKSTVKDQPYIYEMDDTKEITDLFKDNTKSAFSLQNFVKCGRIYNKIAPGEWFGPATTATCIRYLIQENPCYGIEACYISVSSGDIFKENIQGMIDRYPNGNILILLGIKLGLDSVHERYWGEIKTMLESPFSVGIAGGRPSSSLYFFGYFDDTLLFFDPHNSQTALIDDFDESCHTENFGKLNFSDLDPSMLLGFLLPCSKWDEFQEFTSLLTIVNVLDGMDQYRDPDLNSNDIGNVELSPQLKLSQTPDAITDDDYVDIGALIQGNSMNINDRDNGYQEVQCKNQQIVIMDSLNETKPLEIEKVLVGQGTNLVNATTPCREAFPK", "function": "Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.", "AFDB_id": "AF-Q6FP20-F1-model_v4" }, { "swissprot_id": "Q8D2B6", "sequence": "MKIKNKSMVYWSCRRGMLELDIIINNFFKKEFDFLSNKEKIFFVNMLSYDDIYLYKCLIFNYEPKNKKIKKIIKLIKRSSFSFS", "function": "An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.", "AFDB_id": "AF-Q8D2B6-F1-model_v4" }, { "swissprot_id": "B1LS97", "sequence": "MDDHSPRDAAETPAPGPAATPAKRVYETPPTSRPITDAEAARAEKLAANEHIKIASGYLRGTLADGLLKHATGAISEDDGQLVKFHGMYLQDDRDLRPERTKKKLDKAYSFMIRLRIAGGVITPKQWLILDDIARTYAGGALRATTRQTFQYHGVIKSNLKRTMAAIDGALLDTIAACGDVNRNVMAATNPAQTGAHKAAYQLAKDISDSLLPKTSAWREIWLDGERVVGGEDEAEVEPVYGRTYLPRKFKTVVAVPPSNEVDIFAHDLGFIAILDKKNQVTGWNVTVGGGMGMTHGEPDTFPRTADVMGFVKPEDALKVAEAVMTVQRDWGNRKNRKNARLKYTIERYGLDAFRAEVEKRVGKKLGAPKPFTFTGNGDRYGWVEGDDGRHHLTLYVPSGRIKDIDGGPQFLSGLRRIAEVHQGDFRLTGNQNVIIANVPAEKRAEIDALVDEYGLTRGASALRRSSLACVALPTCGLALAESERYLPDLMTELEESLASHGLAEEEITIRSTGCPNGCARPFISEIGLVGRGPERYHLYLGAAHDGSRLSKLYKEDVAASEIRDTLDPLFADYARGRQPGEHFGDYLIRAGHVARTTNGPDFHDRTGALKPATLG", "function": "Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.", "AFDB_id": "AF-B1LS97-F1-model_v4" }, { "swissprot_id": "Q8G846", "sequence": "MAEKAKAEGNNFVKKLLSSNLTWSIVAFILLVIICTIFQHDFLALSWNSNTGGLAGPLITMLQESARYLMIATGMTLVISTAGIDLSVGSVMAVAGAAAMQTLSNGMNVWLSILIALAVGLAIGCVNGALVSFLGLQPFITTLIMMLAGRGMAKVITSGENTDASAVAGNEPLKWFANGFILGIPANFVIAVIIVILVGLLCRKTAMGMMIEAVGINQEASRMTGIKPKKILFLVYAISGFLAAIAGLFATASVMRVDVVKTGQDLEMYAILAVVIGGTSLLGGKFSLAGSAVGAVIIAMIRKTIITLGVNAEATPAFFAVVVIVICVMQAPKIHNLSANMKRKRALKAQAKAVAA", "function": "Part of the high-affinity ABC transporter complex FruEKFG involved in fructose uptake. Can also transport ribose and xylose, with lower affinity. Probably responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-Q8G846-F1-model_v4" }, { "swissprot_id": "P49785", "sequence": "MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDSGEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETADDDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLETLIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK", "function": "Involved in forespore engulfment. Forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling.", "AFDB_id": "AF-P49785-F1-model_v4" }, { "swissprot_id": "Q9VYQ5", "sequence": "MHLNIALWACGALLAVLLAWQQRKCWRLIWQLNGWRGVIQQPVLWLLLCINLHPNSILEKVSQYRVHFQRPLAVLVGTRVLLYIDDPAGMECVLNAPECLDKTFLQDGFFVRRGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVSCLTIMGTPTNFTQLDDAHIAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELYEESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGEMTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVGQVGLEQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQSDFELEKLQFVENISLKFKNADDILLTIQPKKEST", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9VYQ5-F1-model_v4" }, { "swissprot_id": "P39362", "sequence": "MILHPSLASANPLHYGRELTALDNLDFGSLHLDIEDSSFINNITFGMKTVQAVARQTPHPLSFHFMLARPQRWFNALAEIRPAWIFVHAETLDYPSETLTEIRHTGARAGLVFNPATPIDAWRYLASELDGVMVMTSEPDGQGQRFIPSMCEKIQKVRTAFPQTECWADGGITLAAAQQLAAAGAQHMVIGRALFSSSDYRATLAQFATL", "function": "Probable pentose-5-phosphate 3-epimerase.", "AFDB_id": "AF-P39362-F1-model_v4" }, { "swissprot_id": "Q9NVX0", "sequence": "MAAANPWDPASAPNGAGLVLGHFIASGMVNQEMLNMSKKTVSCFVNFTRLQQITNIQAEIYQKNLEIELLKLEKDTADVVHPFFLAQKCHTLQSMNNHLEAVLKEKRSLRQRLLKPMCQENLPIEAVYHRYMVHLLELAVTFIERLETHLETIRNIPHLAANLKKMNQALAKMDILVTETEELAENILKWRKQQNEVSSCIPKILAEESYLYKHDIIMPPLPFTSKVHVQTINAK", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.", "AFDB_id": "AF-Q9NVX0-F1-model_v4" }, { "swissprot_id": "Q0S7V2", "sequence": "MTPPPADDTSGKSGRRTELLDIAATLFAERGLRATTVRDIADAAGILSGSLYHHFDSKESMVDEILRGFLDDLFGKYREIVASGLDSRATLEALVTTSYEAIDASHSAVAIYQDEVKHLVANERFTYLSELNTEFRELWMGVLEAGVKDGSFRSDIDVELAFRFLRDTAWVAVRWYRPGGSVTVDTVAKQYLSIVLDGLASPHN", "function": "Controls the expression of a small regulon that may play a role in the utilization of cholesterol.", "AFDB_id": "AF-Q0S7V2-F1-model_v4" }, { "swissprot_id": "Q9JL59", "sequence": "MLAYSVTSSGLFPRMLWALLLLAASLNAHNDVWDEPCCTEHEVSVNRGSRVVMACNISNNLRDVTIELVTSEKTSIIFNHTPPGNYSKDSWQLHIQGVQAQLVITDAQDKHSGNYSWKLHGFQAEFKNFNLTVNAADRQKTEDLPVTKVPDKPPTAVRTEVIIIIAIATTIIITGIGVFVWYKQFPVAPQIQMSVPCLIHGSPGIPYLTLPP", "function": "May be involved in thymocyte signaling.", "AFDB_id": "AF-Q9JL59-F1-model_v4" }, { "swissprot_id": "B3VA59", "sequence": "MNFISIIIPTFNEEKYITKCLENWFNQDYPKENYEILIFDGKSTDKTLDVIKELQKKHNFENIKIYTNEKRKQVYAFNEGIKNANGDFFIIFGAHAYPEQDFLKNNIETYQRIKKEEPKLAGVGGIINKISENMSAEIAKVIYSTPLSGGSSFWYAKEGFFSNTVVYGMYDTKMIKESEILFDTDFITGQDFEFNLHLIKEGFKLYTNPNIVSSYYTRSSVKKFIKQTISYGAAKGLMIRKGYFNILWLFPFGFLFMLLSIIITGLLIFIYIMAILIDTIRLLIKTREPLYIALPILLFLFHCLISYGFFKGLIKGNSTFK", "function": "Involved in the assembly of an N-linked disaccharide that decorates the S-layer glycoprotein and flagellins. AglC catalyzes the transfer of 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid (Glc-2,3-diNAcA) from uridine 5'-diphospho 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid (UDP-Glc-2,3-diNAcA) to the AglK product Dol-P-GlcNAc to yield Dol-P-GlcNAc-Glc-2,3-diNAcA. AglC is specific for the monophosphate-linked Dol-P-GlcNAc.", "AFDB_id": "AF-B3VA59-F1-model_v4" }, { "swissprot_id": "Q9K489", "sequence": "MKRSLFGRVWPNVTAVVLFIGLVFPVYWMFATAFKPTGDIISENPVWFPTDITFEHFKTATEADHFWTYVSNSLIVTVCAVVFSLVIALAGSFALARMRFKGRRGFIVGFMLAQMAPWEVMVIAIYMIVRDASMLNSLVPLTLFYMMMILPFTILTLRGFVAAVPKELEESAMVDGCTRAQAFRRVILPLLAPGLMSTSMFGFITAWNELPLVLVVNKEAESQTLPLWLTSFQTVFGDNWGATMAASSLFAIPILILFVYLQRKAVSGLTAGAVKG", "function": "Part of the ABC transporter complex DasABC-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for the translocation of the substrate across the membrane.", "AFDB_id": "AF-Q9K489-F1-model_v4" }, { "swissprot_id": "Q8WWW0", "sequence": "MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGRSARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG", "function": "Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.", "AFDB_id": "AF-Q8WWW0-F1-model_v4" }, { "swissprot_id": "Q9ZGW6", "sequence": "MQTTFTELMQQLFLKLGLNHQVNENDVYTFTFEVDGHIQVLIACYHQQWVQLFSELGADLPTNDNLFGEHWPAHVQGRLDGKPILWSQQSLVGLDIDEMQAWLERFIDDIEQRKEPQNTKFQPNSTSPILFI", "function": "Functions as a specific chaperone for YopT.", "AFDB_id": "AF-Q9ZGW6-F1-model_v4" }, { "swissprot_id": "Q54IK9", "sequence": "MIETSFIKWINSFKDLSNSIEDLKELSNGTIFNEICCQIAPKYFDIDSLRKDGLDNWIFREENIKNIVERVDEFYIEEMGLNDQISSINCEEIANENIDEIILLIEAILGMAMESENNEAVIENILSLDQDTQNDLMVVVAKIQQSHQPNTVDNSKSFDKDGSILSQSPSQSNNSISNNNNNNNIDSSNISKSNISSNNNNNNSSNNNKEEILNLQNEIEKLKREKQEIQNDLDESNIQLSNVTMDRDRITIDKQKTEEVCSSLHESIIGLQKQLDETMAQTTTMNALNDETYKTEINDLHMQVESKEKQLSELKKKVDEANRLANENRSLRDEIDILREKAANAEATEEKLKKHQKKIEEIGDLKKKIKELEDQNDSYIQQTLDLEEQLSKNNTYRTQADSGKQQISSLKIELAKLELSLKSIKEDRDKLSESLNTVELERDSLQSQVTNLRNTIDNQQQEYETKFVDLQSSISLNSGGSGGLGDEVIDGSTKERIARLERDNKRLKEVAEKASELENQLEDANQSKELLTIQIKQLEEQKQQSNNTNNNNNNNNMVDSSEIESLKQQLKEKEKEISTLKRKLEESNLSLDENRKQLVELSQRPTTQSPGDIEKLENYENLLKENDGLEGRLRAARNIIKDLREKHKSYSNQETQLATKDEVITKLEGLVKKKTDINEDLRKQLEEGREESQREINLMLSAFLKIGLEMEQVKIQNISSSKEPRSFLNKKRAD", "function": "Cytoskeletal linker protein involved in tethering membrane bound organelles to the cytoskeleton.", "AFDB_id": "AF-Q54IK9-F1-model_v4" }, { "swissprot_id": "Q82SG6", "sequence": "MNHQARMRWRCRRGMLELDIVLQRFIDNHYEQLDEHQLELFEMLLSLSDHDLWNIIIGNTKEPNNQFQPVLKLLQEN", "function": "An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.", "AFDB_id": "AF-Q82SG6-F1-model_v4" }, { "swissprot_id": "A0A291P0C1", "sequence": "MKKHLLAGACALAMGFAVIPGTFADETCNSPFTTALITGQEQYLHVWTLGMPGVGDESDKLVTISVDPKSDKYGKVINTLSVGGRGEAHHTGFTDDRRYLWAGRLDDNKIFIFDLIDPANPKLIKTITDFADRTGYVGPHTFYALPGRMLIQALSNTKTHDGQTGLAVYSNAGELVSLHPMPVTDGGDGYGYDIGINPAKNVLLTSSFTGWNNYMMDLGKMVKDPEAMKRFGNTMAIWDLKSMKAEKILNVPGAPLEIRWSLKPEHNWAYTATALTSKLWLIKQDDKGEWIAKETGTIGDPSKIPLPVDISITADAKGLWVNTFLDGTTRFYDISEPEHPKEVFSKKMGNQVNMVSQSYDGKRVYFTTSLIANWDKKGAENDQWLKAYDWDGKELVEKFTVDFNELKLGRAHHMKFSSKTNAAELGTNQSFPTRQ", "function": "Catalyzes the oxidation of methanethiol. Can also degrade ethanethiol, but not methanol, methylamine or dimethylsulfide.", "AFDB_id": "AF-A0A291P0C1-F1-model_v4" }, { "swissprot_id": "Q94BY9", "sequence": "MKALRRSYTSTSSGNSSSSSSLPSSSSSSLPSSSSSSPPSSNSNSYSNSNSSSSSSSWIHLRSVLFVANLSSPSSVTSSDRRRKSPWSRRKRKWALTPHQWRSLFTPEGKLRDGGVGFLKKVRSRGVDPSIRAEVWLFLLGVYDLNSTSEEREAVKTQKRKEYEKLQRRCQMLLKCGNGSTDNLEELPSDEANSQCVRFVDDYKITGPMTSQDVVSALNTDSSDTDSCEDNEDVLLLSSFAHSDEKKPEEDNSNNNSEENSSLLVAAASEVQVEVAVHEDFSTWQRIIRLDALRADSEWANYSPYSTAITESKARRLAESVGLKDYDHLESCRLYHAARLVAILEAYAMYDPEIGYCQGMSDLLSPILAVISEDHEAFWCFVGFMKKARHNFRLDEAGIQRQLSIVSKIIKNKDSQLYKHLENLQAEDCSFVYRMVLVMFRRELSFEQTLCLWEVMWADQAAIRAGVGKSPWSRIRQQAPPTDDLLLYAIAALVLRRKLIIQKYSSMDEIVEECNSMAGQLNVWKLLDDAHHLVVTLHDKIETLSQSQSI", "function": "Involved in defense response against fungal and bacterial pathogens. Acts as negative regulator of jasmonate (JA) responses during infection by the soil-born fungal pathogen Verticillium longisporum. Involved in abscisic acid-dependent stomata closure in response to infection by V. longisporum and Pseudomonas syringae. May be a downstream component of brassinosteroid-mediated signaling.", "AFDB_id": "AF-Q94BY9-F1-model_v4" }, { "swissprot_id": "P96613", "sequence": "MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFIPLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEIAVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPILGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNASPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYGKLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKDLIESPLS", "function": "Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.", "AFDB_id": "AF-P96613-F1-model_v4" }, { "swissprot_id": "Q72W11", "sequence": "MNEDPQKKDEPFFKDVEFKASYGKADQIPSQGTPQIAFAGRSNAGKSSLLNAILERKSLAKVSSTPGKTKLLNFFFVNHSIYLVDLPGFGYSANSHKDHEAMMGLLMDYLNLAKDLKCLFLVCDSQRELPEEELELIGTCFERNIKPVLVRTKIDKLNQSDLSKLRKKMKNIHELYPMLETVLVSNKSGKGLPELRKIVYSLIETVKNRLERIEEIS", "function": "Necessary for normal cell division and for the maintenance of normal septation.", "AFDB_id": "AF-Q72W11-F1-model_v4" }, { "swissprot_id": "B5X0N6", "sequence": "MVEGRRRRRFSLSSQQLALLLLLLSFFLCFSVASPRAISDSDLLDETVANSSSSVASLNASSSSSLVKPKEGSFADIIDRALEKEFNESDQNEVADPGSFNNSVAGQQAVLETVARVKSTKKNETKEEKRFQLHDVFNLNNDNRAEDTPTLIDRKDNVFIISNSKSKYPVLQLDLRLISDLVVVIVSATCGGIAFACAGQPVITGYLLAGSIIGPGGLNFISEMVQVETVAQFGVVFLLFALGLEFSTAKLKVVRSVAVLGGLLQILLFMFLCGITVSLCGGKRSEGVFVGAFLSMSSTAVVLKFLMEKNSTNSLHGQVTIGILILQDCAVGLLFALLPVLEGNSGIVHGMLSIGKVVVLLLSFLAVLSILSRTCIPWLLKLMVSLSSQTNELYQLAAVAFCLLVAWCSDKLGLSLELGSFAAGVMISTTDLAEHTLEQIEPIRNLFAALFLASIGMLVNVHFLWTHVDILLASVILVIIIKTTIVTTVVKGFGYNNKTALLVGISLAQIGEFAFVLLSRASNLHLIEGKLYLLLLGTTALSLVTTPLVFKMIPAVVHLGILLKWFSPDSTIEKGEIVRSESGKQRMILMSRQSHSS", "function": "K(+)/H(+) antiporter involved in K(+) homeostasis and osmotic adjustment.", "AFDB_id": "AF-B5X0N6-F1-model_v4" }, { "swissprot_id": "Q43011", "sequence": "MCGILAVLGVADVSLAKRSRIIELSRRLRHRGPDWSGIHCYQDCYLAHQRLAIVDPTSGDQPLYNEDKSVVVTVNGEIYNHEELKANLKSHKFQTASDCEVIAHLYEEYGEEFVDMLDGMFAFVLLDTRDKSFIAARDAIGICPLYMGWGLDGSVWFSSEMKALSDDCERFISFPPGHLYSSKTGGLRRWYNPPWFSESIPSTPYNPLLLRQSFEKAIIKRLMTDVPFGVLLSGGLDSSLVASVVSRHLAEAKVAAQWGNKLHTFCIGLKGSPDLRAAKEVADYLGTVHHELHFTVQEGIDALEEVIYHVETYDVTTIRASTPMFLMSRKIKSLGVKMVLSGEGSDEIFGGYLYFHKAPNKKEFHEETCRKIKALHLYDCLRANKSTSAWGVEARVPFLDKNFINVAMDIDPEWKMIKRDLGRIEKWVLRNAFDDEEKPYLPKHILYRQKEQFSDGVGYSWIDGLKDHANEHVSDSMMMNASFVYPENTPVTKEAYYYRTIFEKFFPKNAARLTVPGGPSVACSTAKAVEWDAAWSKNLDPSGRAALGVHDAAYEDTLQKSPASANPVLDNGFGPALGESMVKTVASATAV", "function": "Essential for nitrogen assimilation, distribution and remobilization within the plant via the phloem.", "AFDB_id": "AF-Q43011-F1-model_v4" }, { "swissprot_id": "Q10412", "sequence": "MNAESCSLILSYISSAPAGNLVLNCTATTNKQTLEANLKSAVYQRYPEFLEDWTNVCVHIIHSYFPKDADYWNVDKLYTSVNRITTLEQSKVVGKEIKNGFTFDAENSTASLENDLQPQFRSHALFMVGSAGPLFSSTARTSRLDSRLPDGGIIAKPVALLPTPSVANSQEYTLDKLSPPSTAKPPASVIEFNPSLAKLPTVKYLQSGPFSSIAPYKNSSSSVIPDSSFHSVACYRASSHYKEAPVEKSIDIDIIQNNLSLLEEDSWTSVPIQGELVELNKLLQHLQLLQNQRITSHNVLSDEERQISVQVQNLILKLAKDYDMSPEDFLMDDFTLSLTQYGAFYRGTLPLSAQPLELPSQQLLRSQSNAALRSNSLSMNGSLSPSSTNVPLQSYRRTTKSRR", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.", "AFDB_id": "AF-Q10412-F1-model_v4" }, { "swissprot_id": "Q9VTN0", "sequence": "MKIYQDIYPISKPSQIFAILPFYSGDVDDGFRFGGLGRWYGRLVALIILIGSLTLGEDVLFASKEYRLVASAQGDTEEINRTIETLLCIISYTMVVLSSVQNASRHFRTLHDIAKIDEYLLANGFRETYSCRNLTILVTSAAGGVLAVAFYYIHYRSGIGAKRQIILLLIYFLQLLYSTLLALYLRTLMMNLAQRIGFLNQKLDTFNLQDCGHMENWRELSNLIEVLCKFRYITENINCVAGVSLLFYFGFSFYTVTNQSYLAFATLTAGSLSSKTEVADTIGLSCIWVLAETITMIVICSACDGLASEVNGTAQILARIYGKSKQFQNLIDKFLTKSIKQDLQFTAYGFFSIDNSTLFKIFSAVTTYLVILIQFKQLEDSKVEDISQA", "function": "Dsx-dependent essential component of pheromone-driven courtship behavior. Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating. Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the release of the neuropeptide tachykinin from a cluster of 8-10 neurons in the SEZ.", "AFDB_id": "AF-Q9VTN0-F1-model_v4" }, { "swissprot_id": "Q5JMM1", "sequence": "MASSASSSSSPSSRPPLMALPSFYRPPWPSERGGEQRATDCWAGSPAAGGGRARATAMGIDLNNTASGGEEDAPAPGPVCRDLWHACAGPVVSLPRRGSAVVYLPQGHLSAAGAGGGIRGEVAVALPPHVACRVVDVELCADAATDEVYARLALRAEGEVFERNLHGGGIEREDDMEDGDEERKSRMLHMFCKTLTASDTSTHGGFSVPRRAAEDCFPPLDHKQLRPSQELVAKDLHGAKWRFRHIYRGQPRRHLLTTGWSSFVNKKKLVSGDAVLFLRGDDGELRLGVRRATQLKNEAIFKAFSSESSKMRTLSAVADSLKHGSVFHICYNPRATASEYVVPYWKFVKSFNHPVCIGMRFKFHFESEDVNERRSGMIAGVSEVDPIRWPGSKWRSLLVRWEDATDCNSQNRVSPWEIEIVGGSISVAHSLSASSSKRTKLCPQGNLDVPALYGNGRPDSVETEKFPRVLQGQELMGSRTHRATCSPQSIDITKSKSFDAWRFLTDTRSCMLGSSTSRLPVQYSGYTHQSVSFGESIGFPEVLQGQEISQTVPPFQGMLPDACSAKSRYELKNYVCTPATMNGLSSANEGYCLSLSTVPPSPPSSLMLYQTGVPQLELASKNNDKSGNDSQPALRQHKLLSETSWDQFKIGKASTPGNATKPGNGGREVDRTSCRLFGFSLTEKIIPTDKDGEKEVSYETDCQNPRMLDLFGYNCSTPGALHALCAAPLGI", "function": "Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).", "AFDB_id": "AF-Q5JMM1-F1-model_v4" }, { "swissprot_id": "Q9BQI6", "sequence": "MEDGTPKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKDNFKAPFYPIQYLGDFLLEKEIQNDEDSQTNSVWTEHSNEETNKDFRKDAGFLEMKGALRETMYRTQKEMQNHEDVNVGSILIQHHKKEKFSGSSKDLKFVKMRNTFGSHTYENQKEIKKKDEDIQRSYTLRRKRKKGKESNCKKGVEHEKIKSTLRRHIYNRDQKEMKNSIFAEYAKESKAMAIKTDVDVVEIKNTLRKHIYRAQAVRYNCIRIDKQPVYNVEVKNAEFPRGVLNLIESLIEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDNIDTFSGRYFHILSALLHLHPPWKSPAMSRYYLELFQCPTCMKGAWSLVEVLIRSCLFNESFCHQISENIGSKVLHLTLLKFFFNLIESEVQHLSQKLYDWSDSQNLKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKFKSNDVFKHELAYLLAGILGAAIDYWIFLGLKMGRNVMRHMSDDLGSYVSLSCDDFSSQELEIFICSFSSSWLQMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGVLGSGKIQVSKKIGQRPCFDSQRTLLMLNGTKQKQVEGLPELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLSRMLLNFCSIFDLSSEFILASKGLTHLNELLMACKSHKETTSVHTDWLLDLYAGNIKTLQKLPHILKELPENLKVCPGVHTEALMITLEMMCRSVMEFS", "function": "Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions.", "AFDB_id": "AF-Q9BQI6-F1-model_v4" }, { "swissprot_id": "Q8R760", "sequence": "MRRKIALFLALIFVGVSLVSCSSKKEAVSGDVVAVVNGEKITNAEYQQIFEQVKEQIESAPTYTKDIWNQDYQGKKFLDFVKENVLDSLVAQKLLVQEAKKKNITVTDKEVEEEYNKEKQFNSKVTKEQIREYLLIDKLLAEYTKDVKVTDEELKKYYDEHKESFEVMRARHILVADEKTAEDIYQRLMKGEDFAALAKEYSIDTATKDNGGDLGEFPHGVMVPEFEEAAFSLKLGEISKPVKTQYGYHIIKSEGITVKPFDEVKGTIESYLLNDKKNKVIKEKYDELVKASKIQKFPENIKVKVG", "function": "Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.", "AFDB_id": "AF-Q8R760-F1-model_v4" }, { "swissprot_id": "K3UFY2", "sequence": "MIRQIQKRPAGSNANPLFLFHDASGTISNYLALGLLGRDVYAIADSRIKAKGDESLQDMSRRYYALIKSTVAEGTILLGGWSLGGMTALQVAWIFSRDPKVNVAGVLMIDSPFPDYRHALSLALESPPSEDGPASTRSDIEKAMLQTVTMLHKWKIPVWRREPQPHTVMLCAGNDVDSDHVALSLVDQFRDSPTLGWNERAGPSVVNESYPIQGHHFSIFDPRNIDSVTKTIVTVTAAMEMMAPEDDEDY", "function": "Thioesterase; part of the gene cluster that mediates the biosynthesis of the lipopeptides W493 A and B. W493 A and B consist of six amino acid residues D-allo-thr, L-Ala, D-Ala, L-Gln, D-Tyr, and L-Val/L-Ile linked to a 3-hydroxy-4-methyltetradecanoic acid polyketide chain. The biosynthesis starts with formation of the linear polyketide chain by the highly reducing polyketide synthase PKS40. The gene cluster contains a putative acyl-CoA ligase (FPSE_09184) for formation of a CoA thioester polyketide. The thiol bond could be hydrolyzed by the putative thioesterase (FPSE_09186) and then accepted by the first T domain in module 1 of NRPS32. The second T domain is responsible for accepting a threonine, which is adenylated by the A domain and epimerized to the D-allo-threonine formed by the E domain. The five successive modules incorporate Ala, Ala, Gln, Tyr, and Val/Ile into the final product, which is released by cyclization.", "AFDB_id": "AF-K3UFY2-F1-model_v4" }, { "swissprot_id": "Q3IK97", "sequence": "MESKEQHLIRQYFILAMFFLFLAGCAQKRSLETTTYENWKTHLAEQSIWQVEGKLAFISPDERQSANLNWQQSQNNNNLVLTTFIGTRILSLKQTANTAELNYDGEQYFDTNATALLKRLTGFALPVNNADSWLKGTIDDQTLKVDQLGRAKSVLWFDSTGKKWQIEYASFVQKSGYWLPSRLTLTHQKIKIKIQLYDWQFN", "function": "Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.", "AFDB_id": "AF-Q3IK97-F1-model_v4" }, { "swissprot_id": "Q9ZJ48", "sequence": "MTTDRNLFFCASLLIFLGVLMSYSLSTYTTVVLYHYGEFHFFIRQLVSAIMGIIIMWGLSRVDPRKWFSRLGFFLLFVPSLLIIGMFFLPESLSSSAGGAKRWIRLGFFSLAPLEFLKIGFTFFLAWSLSRTFVAKEKANVKEELITFVPYSFVFVALAIGVGVLQNDLGQIVLLGAVLAVLLVFSGGSVHLFGLIVSGAFAISVLAIVTSEHRILRLKLWWSNLQNSLFTLLPDKLANALRISDLPESYQVFHAGNAMHNGGLLGQGLGLGQIKLGFLSEVHTDMVLAGIAEEWGFLGLCVCFILFSVMIVLIFRIANRLKEPKYSLFCVGVVLLIGFSLVINAFGVGGIFPVKGLAVPFLSYGGSSLLANCIAIGLVLSLARYTKG", "function": "Peptidoglycan polymerase that is essential for cell division.", "AFDB_id": "AF-Q9ZJ48-F1-model_v4" }, { "swissprot_id": "Q9S7U9", "sequence": "MKKGGFSNNLKLAIPVAGEQSITKFLTQSGTFKDGDLRVNKDGVRIISQLEPEVLSPIKPADDQLSLSDLDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQSSQCPNLVTSYQSFYDNGAISLILEYMDGGSLADFLKSVKAIPDSYLSAIFRQVLQGLIYLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVDQPPPALPSGNFSPELSSFISTCLQKDPNSRSSAKELMEHPFLNKYDYSGINLASYFTDAGSPLATLGNLSGTFSV", "function": "MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Plays a role in abiotic stress tolerance and plant disease resistance through activation of MPK4 and MPK6 by phosphorylation. Acts redundantly with MKK1.", "AFDB_id": "AF-Q9S7U9-F1-model_v4" }, { "swissprot_id": "Q9XI31", "sequence": "MKEDAGNPLHLTSLNHVSVLCRSVDESMNFYQKVLGFIPIRRPESLNFEGAWLFGHGIGIHLLCAPEPEKLPKKTAINPKDNHISFQCESMGVVEKKLEEMGIDYVRALVEEGGIQVDQLFFHDPDGFMIEICNCDSLPVVPLVGEMARSCSRVKLHQMVQPQPQTQIHQVVYP", "function": "Involved in the detoxification and scavenging of methylglyoxal (MG), a cytotoxic aldehyde produced in response to primary metabolism alteration observed during biotic and abiotic stresses. Modulates cross-talk between salicylic acid (SA) and jasmonic acid (JA) signaling pathways during defense responses to pathogens such as Botrytis cinerea.", "AFDB_id": "AF-Q9XI31-F1-model_v4" }, { "swissprot_id": "Q6KI38", "sequence": "MPIDKKQEKNFTNKIQEEGQKSLDTSLTQEIEILEEKLNKNPDHKGTINTTPNDNSTSKNSKDKDFKFKKKTNSQNFKKNANKKPEKEFEEKIVNIARVTNVVKGGRRFSFAAVVVVGDKKGRVGYGHGKALEVPDAIKKAVKDAQNNLIRVPIINKSTVPHEQWAKFLASKVMLKPAPKGKGIIASNSVRAVVELAGYTDIYTKSYGSRSKENVVKAVFDALKKLRYAEDIAKMRDLDIKDL", "function": "Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.", "AFDB_id": "AF-Q6KI38-F1-model_v4" }, { "swissprot_id": "D4GST8", "sequence": "MQLGVIGLGRMGRIVVDRVLDAGHEVVAFDLSAEAVAAAADAGAEPADSVADLVDRLGDDKRIWLMVPAGDAVDATLDDLDPHLDGDDVVVDGGNSHFEESVRRAEACSAAYLDCGTSGGPAGAELGFSLMVGGPQWAYDELTPVFDAVATGPDGHGHMGDSGSGHYVKMVHNGVEYALMQAYGEGFELLAEGRYDLDLESVAKTWNNGAVIRSWLLELCEEAFREEGSDLGDVDDHVAGGSTGTWTVQEALEQEVPVPLIYQSLAERFGSRADDRFSRRLANRLRYGFGRHEVARKDD", "function": "Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.", "AFDB_id": "AF-D4GST8-F1-model_v4" }, { "swissprot_id": "A1CU44", "sequence": "MLPSTISYRIYKNALFFAALFGAVQAQKVGTSKAEVHPSMAWQTCAADGTCTTKNGKVVIDANWRWVHDVKGYTNCYTGNTWNAELCPDNESCAENCALEGADYAATYGATTSGNALSLKFVTQSQQKNIGSRLYMMKDDNTYETFKLLNQEFTFDVDVSNLPCGLNGALYFVSMDADGGLSRYTGNEAGAKYGTGYCDSQCPRDLKFINGLANVEGWTPSSSDANAGNGGHGSCCAEMDIWEANSISTAYTPHPCDTPGQAMCNGDSCGGTYSSDRYGGTCDPDGCDFNSYRQGNKSFYGPGMTVDTKKKMTVVTQFLTNDGTATGTLSEIKRFYVQDGKVIANSESTWPNLGGNSLTNDFCKAQKTVFGDMDTFSKHGGMEGMGAALAEGMVLVMSLWDDHNSNMLWLDSNSPTTGTSTTPGVARGSCDISSGDPKDLEANHPDASVVYSNIKVGPIGSTFNSGGSNPGGSTTTTKPATSTTTTKATTTATTNTTGPTGTGVAQPWAQCGGIGYSGPTQCAAPYTCTKQNDYYSQCL", "function": "The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.", "AFDB_id": "AF-A1CU44-F1-model_v4" }, { "swissprot_id": "Q93Q17", "sequence": "MQIQANTVGTQAVAHHSDATTGVGRMGQMEARQVATGQDAILLGSRSEPQKGQGLLSRLGAQLARPFVAIKEWISNLLGTDKRAAAPKAQTAVSPEDLQRLMKQAAFGSSLGGFAKADVLNNITGEQLGKDHASLATGNGPLRSLCTALQAVVIGSQQPQLRELATGLLARPIAGIPLQQWGSVGGKVTELLTSAPPELLKEAMSQLHTAMGEVADLQRAVKAEVAGEPARSATTAAAVAPLQSGESEVNVEPADKALAEGLQEQFGLEAEQYLGEQPHGTYSDAEVMALGLYTNGEYQHLNRSLRQEKQLDAGQALIDQGMSTAFEKSTPTEQLIKTFRGTHGGDAFNEVAEGQVGHDVAYLSTSRDPKVATNFGGSGSISTIFGRSGIDVSDISVEGDEQEILYNKETDMRVLLSAKDERGVTRRVLEEASLGEQSGHSKGLLDGLDLARGAGGADKPQEQDIRLKMRGLDLA", "function": "Directly involved in the toxicity for RTG-2 (rainbow trout gonad) fish cells.", "AFDB_id": "AF-Q93Q17-F1-model_v4" }, { "swissprot_id": "P22189", "sequence": "MVTINISNPVYFSDIKDVESEFLTSIPNGLTHEEAQNRLSEYGENRLEADSGVSAWKVLLRQVLNAMCVVLILAAALSFGTTDWIEGGVISAIIVLNITVGFIQEYKAEKTMDSLRTLASPMAHVTRSSKTDAIDSHLLVPGDVVVLKTGDVVPADLRLVETVNFETDEALLTGESLPVIKDAHATFQMNEDVPIGDRINLAYSSSIVTKGRAKGICYATGMQTQIGAIAAGLRQKGKLFQRPEKDEPNYRRKLNKYYLKVTSYYVQRVLGLNVGTPLQRKLTVLAYILFCIAIILAIIVMAAHSFHVTNEVSIYAISLGISIIPESLIAVLSITMAMGQKNMSKRRVIVRKLEALEALGGVTDICSDKTGTITQGKMITRRVWIPSYGYLSVDTSDANNPTIGTVSGLEAAMQDVLKEKKQEMKNIDPSNQPSDQFIPLLKTCALCNLSTVNQTETGEWVVKGEPTEIALHVFSKRFNYGKEDLLKTNTFVREYPFDSEIKRMAVIYEDQQGQYTVYAKGAVERILERCSTSNGSTLEEPDRELIIAQMETLAAEGLRVLALATKVIDKADNWETLPRDVAESSLEFVSLVGIYDPPRTESKGAVELCHRAGIRVHMLTGDHPETAKAIAREVGIIPPFISDRDPNMSWMVMTGSQFDALSDEEVDSLKALCLVIARCAPQTKVKMIEALHRRKAFVAMTGDGVNDSPSLKQANVGIAMGQNGSDVAKDASDIVLTDDNFSSIVNAIEEGRRMFDNIMRFVLHLLVSNVGEVILLVVGLAFRDEVHLSVFPMSPVEILWCNMITSSFPSMGLGMELAQPDVMERLPHDNKVGIFQKSLIVDMMVYGFFLGVVSLMTWVVIMYGFGTGNLSYDCNAHYHAGCNDVFKARSAVFAVVTFCILIMAVEVKNFDNSLFNLHGIPWGEWNFRYFLHTLVENKFLAWAIALAAVSVFPTIYIPVINRDVFKHTYIGWEWGVVAVAVMFYFFYVEIWKSIRRSLTNPQKKGKFRRTLSNTITTESKLSEKDLEHRLFLQSRRA", "function": "This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.", "AFDB_id": "AF-P22189-F1-model_v4" }, { "swissprot_id": "Q54WR2", "sequence": "MNEENPSSSIILDDQQQQDSFYSEIKELEKSIQSNKLSERKNTLTRINSIGKHELSTQENDATTTTTTTTVDLEEKLKVLIYLYFTSYSIGPDSQWIFSLVQSLKQLFKDISSATNTSLVTDELKINIVKFTLREIGRLAKLLPTNKRSKYVPQNTLMSFSLVLLNYFIDQIQSNSDLTTLLFAAQELLYRELTLQHMKNNQPIFNQILNKNKILTFYQNIVTKDSSNKSFFIVYFLLRNFTDQSNKQKEQDNTFKINDLLNIYNKTVIGSSQQKIEEHKFFKRLFNQLTNEDLQSIILPPLSRHIKRDQDQVFKILIFILENLSSDFNVIDLSSLLKSMLLPMLLPVIQSTISIEENRKLLKKTFTLIIERSKDTKLISSMITDDLLKTLSVAGNPSQKLIIISIISSIISTKNFIERLSLTTEKLQLSKQILQSISIYLEKELNKDNRNKGFKLLGKVMKMVEELPEQTIKIITNSLKNDDDIIKGQVILSLSKSLGPEANGTNKKVIQIINGFTETINTILKNVKNAKTCDPSTTTASLHYMLSLITTTGVPKNDIFTKYSTDKTTISNLYASTSFLHTDGFIQRTSKKDHAIDLLLTLFLRVKSFPSIKLNDKSPLYSSVLNCLLHSQWSVSKHSAIKIRSILSRNDSVDIDYPLLSNQLLIEFSTILFDDSLIITPQIINSNVESTTTTTTTISNKKNYLIAFRSILSKNIKSELYPMLSLICYHPFINYNWKRVSSLIQNDVNTTLSSNAIEISKYIFEKGLNQKKNKSYQQAFQQAINGLMNYNVPLLNEELVKLMVKALSYEPVLAITQQQWSIYHTLPTELFVEKQEQLVESRNDRKVKPKTAEEQRDEESRKRIEEKKKIQSGELEKQEKERQKQLAAQAVIRKDVQDVIDRLHLAMDTCQTMAKSSSNPQFVGEFMSPIIVALLQLMKHEITNHQFTQVFEKLICCVPSRFKLDRSFARHYIYIINNIYYRPTLSEIQILGFIQKILTHIRESIAKEALSGFAFNYFWPIIKNGLETTISFTIQEISMEIIQKHTAQGQAYPRGSMISSLIIVVSTNSRLEAQARNTIFQLIEGVETSDIGELMEGIISKHVQVRSICLQAIEKIPSIYSPSFVWEDKYIGSLWFARFDNHDANTSALAEKIWLATNQPTQLPEDFMKLLSDSTFNVNSETRKINALAIKEAATCHTHMIPEIVDNLFEIYEQNYPDEIRETPITSKFRISVATALSGLGNAIVEPEVLKSLFTKIIERGLFDPKEEVVQEFVSTGMSIINQQGVQFSGELLATFEAFLARPDNGTGEEDSIRANVVVYMGALAKHMDASNPKVSIVIDKLVDALSIPSESVQVGISKCIAQLIPSFKKQGDRLIPMLLEKLKNSSGNYADRRGAAFGLAGSVKGLGIGSLKNYSILDTLQSYIEDKKHPTSRQGALFAFECLCNTIGRVFEPYIIHILPKLLVCFGDNVSEVRDATADTAKAIMSQLSGHGVKIVLPALLKALDDRSWRTKEGSIELLGAMAFCAPKQLSSCLPTIVPKLTYVLNDTHTKVQEAAKEALSHIGSVIRNPEIQIHVPLLLQTYDDPEIHSKELLENLLSTNYVHTIDPASLSLLLPILERTLKERSSELKKMSCQIVGNLCSLTEPKDLVPYLNILMPVMKTVLLDPIPEVRAICARALGLLVRGMGEENFSTLIPWLLETVKSDQGAVERSGAAQGLSEVLASLDISRFNSLINELLAMTNSPRPHVREGILSIFIFTPISLGDLFLPYLPKVLPQVLKGLADDSDPVREVCMRCGQSIVLQFAVTGIEVIVPALEKVLFHENWRIRLSCVQLFGDLLFKLAGTTAQEVQSNNSSYNAKDDDDDEPGSSGNDIQKILGKERLGRILSSLYMMRFDNNSSVRQKVLLIWKYIVSNTPKTLREILPTLIEMIISSIGSNNVEKRQISAKTLGDIVSKLSDRILPEILPILERGLRSELEETRQGVCIGLSEVISSAKTQLLPYLSSVVTCITKALCDPLIDVREAAAKAFDHLYHTFGSKASNEILPQLIQLLDNSNNKDLAGYALDGLRQVILVRSSIVLPVLIPKLLSRPISTSNVTALSSLAADAGEGLYVHLSTIIPSLIESFTNPNTISNAKEIKEAAVSICKSIDEQGWDTLIGLLIEQTEIRLPNIRLGACELIGEFYNGNTMVTEYPEELLLSLLSLFNDPDALVQQAANNALGFITKSLKKDNLTYLPVFQKGIQLLVNETYEEVSTIPGFCLPKGLASVLPVLISGLMYGTSDQREQATNTLRTVINHTSADALKPFVMQITGPLILVIGDKFPWQVKSAILQTLSLLISKSPASMKIFLHQLQPTFIKCLSDSHKNVRTNAASALGLLMTLSSSVDQLVNSLITGISTADSISQESKLRALQSIFEKKPKVEQATLDKAIATIVDFLYQPSDDLRSMVAQTIGASSKCFTSLTELNQFIKTNLISPSQSVLSRYGKSLALGEIFKASGKNLIDSQSPNMPTIIKIIQTDCRDEKGPIRESSAYLAEAILVASPLTYAKDLVPSICHLIGDQSSSVSISALNVIKRFCKSNQQLSRQYLRDIVVPTMNRLKERTNLPLKLAAERTLVHSLQIFKESIVMDDLIKQLELSGDSSMANSLIDYHKRVLMKLSPDSDIEK", "function": "Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation. Forms a complex with eif2ak4/gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of eif2ak4/gcn2, and hence stimulating eif2ak4/gcn2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator atf4, by promoting the eif2ak4/gcn2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/eif2s1) on 'Ser-53', and hence allowing atf4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.", "AFDB_id": "AF-Q54WR2-F1-model_v4" }, { "swissprot_id": "G3XMD0", "sequence": "MFRTILLCSLGLTTLSSAATHNITSIFSSSLSPGAQIFLPSDTNYTEDVTQRWTTYDAPTYIGAIKPATVKDIQNIVTLAASNKIPFLATAGGHGATITYVNCTNGIEIDISNFNTVSIDASNNTMTVGGAVRFEDIIPPLYEAGKELPTGTAPCVGLVGATIGGGIGNLQGLHGLILDSLLSVELVTPSGDVLTVSTSENADLFWAIRGAGANFGIITSATYKIYNATNNGLAMSANYLFPASENRSVWEIFQSFDETLPPELSLTAYSGFNQTTQEMELIVNAIYYGPKEEGVSYLTNFAALNATETNLMMVAWPNVTSSMAFGADGDACTTGSYLNTWGLGLAETNIDTYTTFFNELQAFSQAHPDYSGIFVVDRYSSAAAAAVPANSTSYGYGYRNINSHLLFENSYPSDNSTLDNAVNSFMRSIRSQFQRTSGFSEMEIYLNYAHGDEGADVWYSPQHLPKLSQLKS", "function": "FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of azaphilones, a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities. In the first step, the non-reducing polyketide synthase azaA forms the hexaketide precursor from successive condensations of five malonyl-CoA units, presumably with a simple acetyl-CoA starter unit. The reactive polyketide chain then undergoes a PT-mediated C2-C7 cyclization to afford the aromatic ring and is eventually released as an aldehyde through the R-domain. The putative ketoreductase azaE is proposed to catalyze the reduction of the terminal ketone resulting in the early culture product FK17-P2a. The monooxygenase azaH was demonstrated to be the only enzyme required to convert FK17-P2a to azanigerone E. AzaH first hydroxylates the benzaldehyde intermediate FK17-P2a at C4, which triggers the formation of the pyran-ring to afford azanigerone E. In parallel, the 2,4-dimethylhexanoyl chain is synthesized by the HR-PKS azaB and is proposed to be transferred to the C4-hydroxyl of azanigerone E by the acyltransferase azaD directly from the ACP domain of azaB. Alternatively, the 2,4-dimethyl-hexanoyl chain may be offloaded from the HR-PKS as a carboxylic acid and converted to an acyl-CoA by azaF. The resulting acyl-CoA molecule could then be taken up as a substrate by AzaD to form azanigerone B. To yield the carboxylic acid substituent in azanigerone A, the hydroxypropyl side chain of azanigerone B would need to undergo a C-C oxidative cleavage catalyzed by cytochrome P450 AzaI. AzaI is proposed to act on a vicinal diol that leads to a C-C bond scission either through an alkoxyradical intermediate or a peroxy complex. In the biosynthesis of azanigerone A, azanigerone B first undergoes hydroxylation at C10, possibly catalyzed by one of the two FAD-dependent monooxygenases encoded in the cluster, azaG or azaL, resulting in the vicinal diol azanigerone C. Oxidative cleavage of azanigerone C by azaI would yield the corresponding aldehyde derivative of azanigerone A. Finally, the dehydrogenase azaJ is proposed to convert the aldehyde functional group into the carboxylic acid, completing the conversion from azanigerone B to azanigerone A. Alternatively, the oxidation of aldehyde to carboxylic acid may be catalyzed by the same P450 enzyme azaI via consecutive oxidation or by endogenous alcohol dehydrogenase.", "AFDB_id": "AF-G3XMD0-F1-model_v4" }, { "swissprot_id": "A4QH48", "sequence": "MDLNTQRSKLYAQLQGQLIVSVQAPDGHAMRDTHTLTHVAAACVDGGAPAIRCGGYGGLEDIRSISNRVDVPVFGLTKEGSEGVYITPTRDSVRAVAESGATVVCADATFRPRPDGSTFAELVTVAHDSGILIMADCATPEEVLSAHKAGADFVSTTLAGYTEHREKTVGPDFDCLREARELVPDAFLIGEGRFSNPADVAHGRLIGANAIIVGTAITDPGFITGQFASLLH", "function": "Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).", "AFDB_id": "AF-A4QH48-F1-model_v4" }, { "swissprot_id": "P22211", "sequence": "MSSLTRLLQEKRKNETSNSSPRTSADTLTTTPESQSLDLHSRNKSSSHIGSVSNSSSSDRNRANVPVPGSVTTVTQIYSEEDSSSTAGSSLDDRNQFSSSFLNANFAHTASFYGTSAQSRDRFGSLINDQGTAGLSSHGGSFAAQNRITSRLSTTSHTSGRAIPSLSSSIPYSVPNSNKDNNSSNSNSSSLSSSWLETYAGGMPNNISAIDSNVISSPKVDSVEPRFVISKQKLQKASMDSNNANATQSRSISRSGSFSSQLGNFFFSKNSKESSNSNSAGMSFSANSNGPSPNIKNPNVTNGSTPIPKPIRARQSSIYSASRQPTGSYTDNFYGSPSSVHDHLPPSQSVPRSQHSSIGDLKRFFKKSSNSNLSSNSNNVIPNGSPLSSGIAVPSHSHSSSHFAAGNNSYSTSYNGNGDTIYSHSHGGSGIPFSKRYIKTGADLGAGAGGSVKLAQRISDNKIFAVKEFRTKFENESKRDYVKKITSEYCIGTTLNHPNIIETIEIVYENDRILQVMEYCEYDLFAIVMSNKMSYEEICCCFKQILTGVQYLHSIGLAHRDLKLDNCVINEKGIVKLIDFGAAVVFSYPFSKNLVEASGIVGSDPYLAPEVCIFAKYDPRPVDIWSSAIIFACMILKKFPWKIPKLRDNSFKLFCSGRDCDSLSSLVTRTPDPPSYDESHSTEKKKPESSSNNVSDPNNVNIGPQRLLHSLPEETQHIVGRMIDLAPACRGNIEEIMEDPWIRSIDMCHLVEDGLSFKVVRGEDHHHTQVDQSEAHIAGLEKKKKKQNNQ", "function": "Nutrient-regulated protein kinase that promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression. Under poor nitrogen growth conditions, required for post-Golgi sorting of the general amino acid permease GAP1 and the three known ammonia permeases, MEP1/2/3, to the plasma membrane. Contributes also to the stability and the retention of GAP1 at the plasma membrane. Inversely, promotes the degradation of tryptophan permease TAT2 under the same conditions. Activity is regulated by the TOR signaling pathway via phosphatase SIT4. Although thought to be involved in regulation of GLN3-dependent transcription by nitrogen catabolite repression, this seems to be an indirect effect from the reduced uptake of the nitrogen-repressing compound.", "AFDB_id": "AF-P22211-F1-model_v4" }, { "swissprot_id": "P0DPE6", "sequence": "MSSAIKILALLMVLVALAQAKPRKDYRAYPDFDDKSVILEDDKRCDPDKRDSVCKDVCGMLDIGTENGECPGKEVCCVDLFGR", "function": "In vivo, induces immediate paralysis on shrimps (C.multidentata), followed by death when high doses are injected. No activity is observed when injected into fly larvae (M. domestica).", "AFDB_id": "AF-P0DPE6-F1-model_v4" }, { "swissprot_id": "Q9WYP5", "sequence": "MRIGVIGLGRIGTIHAENLKMIDDAILYAISDVREDRLREMKEKLGVEKAYKDPHELIEDPNVDAVLVCSSTNTHSELVIACAKAKKHVFCEKPLSLNLADVDRMIEETKKADVILFTGFNRRFDRNFKKLKEAVENGTIGKPHVLRITSRDPAPPPLDYIRVSGGIFLDMTIHDFDMARYIMGEEVEEVFADGSVLVDEEIGKAGDVDTAVVVLRFKSGALGVIDNSRRAVYGYDQRIEVFGSKGRIFADNVRETTVVLTDEQGDRGSRYLYFFLERYRDSYLEELKTFIKNVKSGEPPAVSGEDGKMALLLGYAAKKSLEEKRSVKLEEVIG", "function": "Catalyzes the NAD(+)-dependent oxidation of myo-inositol (MI) to 2-keto-myo-inositol (scyllo-inosose), and thus probably functions in a myo-inositol degradation pathway together with IolM, IolN and IolO. Has no activity with scyllo-inositol and much reduced activity (78-fold lower catalytic efficiency) with 1D-chiro-inositol.", "AFDB_id": "AF-Q9WYP5-F1-model_v4" }, { "swissprot_id": "A1A3X8", "sequence": "MERLKSHRDFVAVLKRRRRVSREDIVVHYLMHDDVVTGDTATVQGRRVGLAVSKAVGNAVTRNAVKRRFRVLARKYESLLPESCDIVLRAKPSAARADFLSLEQQMASCFEAVKRKTASRQ", "function": "RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.", "AFDB_id": "AF-A1A3X8-F1-model_v4" }, { "swissprot_id": "A0A0A7HFE6", "sequence": "MRVLISAVGDTDPFRNFHDGSLIHIARKYRPEKVILIFSEHTAKKQGNIEKALFSIAPNYEPELIIHDPIISDNEVHIFDVMFQRFSDILQEYYTKEDEFILNLSSATPQIKSALFVINRLNGINVKAVQVSSPEHASNENIGHDNDENIDELIEVNKDNKVNFIDRTIEDNAEKFSQALLKKTARDFIEKFDYKAALDILDQLSDFPNLKSVREEIRDVVNCLSKQDVPKGLRHKKLKEEEQKILSAYLTIELQRERGNVSESFIRIKNLTEFILEDYIEKRYPGLIDEYCEDIQKYYLSLFDYSKLLKATKEFKLKRTIAPIIDMNSSRNKVAHSLSPLDSDAVKQLGIAMKTLKTLVREQYHFSQSDFNFYHDLNKILLTKLN", "function": "A single-strand-specific endoribonuclease (ssRNase) that is approximately 1000-fold stimulated by cyclic oligoadenylate (cOA); although several species of cOA are synthesized by this organism only cyclic hexaadenylate (cA6) stimulates the ssRNase activity. Cleaves preferentially within GA or AA dinucleotides, although the presence of cA6 broadens the preference.", "AFDB_id": "AF-A0A0A7HFE6-F1-model_v4" }, { "swissprot_id": "P0DOX2", "sequence": "EVQLVETGGGLIQPGGSLRLSCAASGFTVSNHSMSWVRQAPGKALEWVSAIYRGGTTYYADSVKGRFTISRDDSRNTVYLQMNSLRAEDTAVYYCARDLAAARLFGKGTTVTVSSASPTSPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQDASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNSSQDVTVPCRVPPPPPCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVEGPPERDLCGCYSVSSVLPGCAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTYAVTSILRVAAEDWKKGETFSCMVGHEALPLAFTQKTIDRLAGKPTHINVSVVMAEADGTCY", "function": "Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Ig alpha is the major immunoglobulin class in body secretions.", "AFDB_id": "AF-P0DOX2-F1-model_v4" }, { "swissprot_id": "P61540", "sequence": "MENLQSMPEVQKIISLGKANGEVSYDDINEILPDKILNSEKIDDFFTLLHEMGIEIVEEYTRNTLEPASTLVPKDDSKPARKKKESSASTSGSEDPIKLYLREIGKVSLISGETEVFLAKRIEKGEKIIEETILSSSILRANYIKLLPKIRSKKIKVYDLIRVDKMYALNAEEAHKLEELFFKNILVIQEQEKVLQEAVSKIRKYSETSKKYKEFKEKIDASTEIIHNAIRELGVSQKEIQKISQKIKSMVFRIKEIDRHFLKIKAQYGQDVRDIKAFNRFIEKNEKLDDIEVKMGVNIDEVREVIKDIRNNERKLRRMEQEAGSTVQEIKDWGEKIIKGEREISQAKKELVKANLRLVVSIAKRYANRGMHFFDLIQEGNIGLIKAVDKFEYKKGYKFSTYATWWIRQAITRAISDQARTIRVPVHMIEQVNKVIRETRLFIQEFGRDPNNEEIAERLGWPVQKVKMVKNVAREPISLEIPVGSEEDSELGDFIPDTEVETPVNAAASSILAEQIRQVLHTLPAREQKVIRMRFGLDDGYPQTLEEVGYQFKVTRERIRQIEAKALRRLRHPSRSKKLKDYIDG", "function": "Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.", "AFDB_id": "AF-P61540-F1-model_v4" }, { "swissprot_id": "Q6X7J4", "sequence": "MASSNRHWPSMFKSKPHPHQWQHDINSPLLPSASHRSSPFSSGCEVERSPEPKPRWNPKPEQIRILEAIFNSGMVNPPREEIRRIRAQLQEYGQVGDANVFYWFQNRKSRSKHKLRLLHNHSKHSLPQTQPQPQPQPSASSSSSSSSSSSKSTKPRKSKNKNNTNLSLGGSQMMGMFPPEPAFLFPVSTVGGFEGITVSSQLGFLSGDMIEQQKPAPTCTGLLLSEIMNGSVSYGTHHQQHLSEKEVEEMRMKMLQQPQTQICYATTNHQIASYNNNNNNNNIMLHIPPTTSTATTITTSHSLATVPSTSDQLQVQADARIRVFINEMELEVSSGPFNVRDAFGEEVVLINSAGQPIVTDEYGVALHPLQHGASYYLI", "function": "Homeodomain transcription factor required for meristem growth and early development. Promotes cell proliferation and prevents premature differentiation in meristematic tissues during postembryonic development. Essential for maintaining tissue growth during embryogenesis. May act by repressing TSS to promote meristematic proliferation. Involved in the transcriptional activation of a subset of cytokinin response factors. May act as a negative regulator of cytokinin signaling in the dark.", "AFDB_id": "AF-Q6X7J4-F1-model_v4" }, { "swissprot_id": "Q16S34", "sequence": "MELKTCCIILPLLCTLTSYAEALDHAAILKSPNELQLECSKYLPSIDVSQNVDCYDRCIGLVGRFWNDSIGRPAQTIARYYQPDTGSQDHITRTDQCLCEKVLTVPRNAYCQRASSGLQCYLDNYGQLLTGTPQFVPVTEIRAAQIFWDCAQMLQISRDRLTQIFKDGYNKTSEGRCLIRCFLVRAGLYSDRQGPNIGRFAVQCEGYTAEYEQAVVSCYDRLKKESLDSCSLATRTMDECIQGNQFSSSDIDGLEKLEVQ", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.", "AFDB_id": "AF-Q16S34-F1-model_v4" }, { "swissprot_id": "Q02862", "sequence": "MKFFIFACLVVVALAKHEIKDKSSSEESSASIYPGKSKLDNSVFFQTTKDSASSSSSEESSEEVSEKIVQSEEQKVNLNQQKKFKQFSQESSFSQCCTPLHQQQQSSVNQWPQPNAIHNTPTQESISTSVEEILKKIIDMIKYIQYQQVTIPQLPQALHPQIPVSYWYPSKDYTFPNAHYTRFY", "function": "Important role in the capacity of milk to transport calcium phosphate.", "AFDB_id": "AF-Q02862-F1-model_v4" }, { "swissprot_id": "Q0VCT9", "sequence": "MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGASNMNASSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSSTPGGSAGTSGGGAGSSNSGGGSGGGSSSNMPASVAHVPAAVLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC", "function": "Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.", "AFDB_id": "AF-Q0VCT9-F1-model_v4" }, { "swissprot_id": "Q7XL73", "sequence": "MGILVILVDLQCCRCDAKIRKVLGCLEEEYCIEKVEYDVKNNRVIVRGKFDPEKLCKKIWCKAGKIIKEILIVDVWPPPLPQPPPPCKPPPCEKPPEDCKPKPCHCCSCEKPKPKPKPCHCEKPKPCHCEKPKPCEKPPPCKPEEPPKPPPEKPPPKPECKLVPYPYPVPYPYAGQWCCPKPEPPKPPPEPPKEPEPPKPCGCSHAFVCVCKPAPPPPPPCGCSGGHGNCGCGIRPWPPQVWPPPPVCPPPPWCYTEDNANACSIM", "function": "Involved in defense responses. Contributes to slowing defense responses toward Magnaporthe oryzae.", "AFDB_id": "AF-Q7XL73-F1-model_v4" }, { "swissprot_id": "Q93702", "sequence": "MNRSMIALCVVLMVSLVSAQVFDLDGQQLAGLEQNDARLMEQQVKRSPSAKWMRFGKRSPSAKWMRFGKRSPSAKWMRFGKRSGAEAVSEQDY", "function": "SPSAKWMRF-amide: Acts as a ligand for the npr-22 receptor in vitro.", "AFDB_id": "AF-Q93702-F1-model_v4" }, { "swissprot_id": "M1W855", "sequence": "MSASVFIERRKIRPLRTEAACIPTHALCFNVLGIPYMDPGNGGIRPLNPDDSDATACVHGVAYLLTSDDLKKVILSEGGGIAYQVARLNAKLLLDDSPIVVDTLIGRHNVDASNERLPSARYIGVLTRGANELNLPLSYQRRLAEQPIYQPKSGWWFQLGVALFLWPWTRAAIITERLVYKHQGPDGHVPAWFLFIFDCLLWLMWAQHDYIHGPIFGRGDGR", "function": "Gamma-glutamyl cyclotransferase; part of the gene cluster that mediates the biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) lacking the reactive thiol group important for toxicity. Firstly, L-tyrosine is prenylated by tcpD, before undergoing condensation with L-glycine in a reaction catalyzed by the NRPS tcpP leading to the diketopiperazine (DKP) backbone. Afterwards the alpha-carbon of tyrosine is oxidized by the cytochrome P450 tcpC to form a hydroxyl group. However, in contrast other ETP biosynthesis pathways studied so far, tcpC is not able to bishydroxylate the DKP at both alpha-carbon positions, but hydroxylates the alpha-carbon of the tyrosine part and the nitrogen of the glycine part. The next steps involve an alpha,beta-elimination reaction catalyzed by tcpI, a methylation by the methyltransferase tcpN the action of the four enzyme cascade tcpG/K/J/I. Due to a dysfunctional cytochrome P450 monooxygenase tcpC, the pathway leads to the biosynthesis of probable non-toxic metabolites lacking the reactive thiol group.", "AFDB_id": "AF-M1W855-F1-model_v4" }, { "swissprot_id": "P56525", "sequence": "MNSLRIARAALRVRPTAVRAPLQRRGYAEAVADKIKLSLSLPHQAIYKSQDVVQVNIPAVSGEMGVLANHVPSIEQLKPGLVEVIEESGSNKQYFLSGGFAVVQPGSKLSINAVEGYALEDFSAEAVRAQIAEAQKIVSGGGSQQDIAEAQVELEVLESLQAVLK", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.", "AFDB_id": "AF-P56525-F1-model_v4" }, { "swissprot_id": "Q18GT4", "sequence": "MTETKTQTETETDEEEGTDTDTALDTTIYYDDDADREYIDDKTVAVLGYGSQGHAHAQNLADSGIDVIVGLYEGSSSRDAARADGLRVETPATAADEADIVSVLVPDTVQPDVFEAIQDGLDAGDTLQFAHGFNIHYNQIQPPADVDVTMVAPKAPGHLVRRNYEAGEGTPGLVAVYQNTTGTARKEAVAYAHAIGCTRAGAIETTFREETETDLFGEQAVLCGGATALVKQGYETLVDAGYSPEMAYFECLNELKLIVDLMYEGGLSEMWNSVSDTAEYGGLTRGNQVIDESVREEMESILEGVQDGTFAREWISENQANRPSYTQLKAAEEAHEIEAVGEPLRDLFAWSDNEETNDESDVVSEPEAAADD", "function": "Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.", "AFDB_id": "AF-Q18GT4-F1-model_v4" }, { "swissprot_id": "E4QWH3", "sequence": "MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL", "function": "Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of toxin VapC1. In vitro inhibits the RNase activity of VapC1.", "AFDB_id": "AF-E4QWH3-F1-model_v4" }, { "swissprot_id": "Q4GZK9", "sequence": "MGAEAVRVLVVDDSPVDRRVVELLLRAHCGGGGGAAAGEAAPFHVTAVDSGKKAMELLGRRRGDRDHLTPSSPAAAAAANDQAIDIVLTDYCMPEMTGYDLLKAIKALGSPNPIPVVVMSSENEPQRISRCLTAGAEDFILKPLKMNDVQRLRKCSGATRPKSAVAGDDDRCCNTAKKAAAAAAATPEQQQQQQRSSHLAGLAMVMNASSFEVSHYFQLIFKLILLAYAVLCLSQLLHRWSNGSSLLSLWCA", "function": "Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.", "AFDB_id": "AF-Q4GZK9-F1-model_v4" }, { "swissprot_id": "P85147", "sequence": "NRWYCNSAAGGVGGAAVCGLAGYVGEAKENIAGEVRKGWGMAGGFTHNKACKSFPGSGWASG", "function": "Bacteriocin active against the Gram-negative bacteria S.enteritidis, S.choleraesuis, S.typhimurium, S.gallinarum, E.coli O157:H7, Y.enterocolitica, C.freundii, K.pneumoniae, S.dysentriae, P.aeruginosa, P.mirabilis, M.morganii, C.jejuni and 20 other Campylobacter isolates, and the Gram-positive bacteria S.aureus, S.epidermidis and L.monocytogenes.", "AFDB_id": "AF-P85147-F1-model_v4" }, { "swissprot_id": "Q6UXN2", "sequence": "MAWGGVHTCCFHLCCCCSWPQGAVPEELHKHPGQTLLLQCQYSPKRGPYQPKSWCQQTSPSRCTLLVTSSKPWTAVQKSHYTIWDKPNAGFFNITMIQLTQNDSGFYWCGIYNASENIITVLRNISLVVSPAPTTSPMWTLPWLPTSTVLITSPEGTSGHPSINGSETRKSRAPACLGSGGPRFLVLVLCGLLLAKGLML", "function": "Positively regulates Toll-like receptor TLR7 signaling in macrophages.", "AFDB_id": "AF-Q6UXN2-F1-model_v4" }, { "swissprot_id": "P38208", "sequence": "MGKKTFREWQYFKLSITSFDQDVDDAHAIDQMTWRQWLNNALKRSYGIFGEGVEYSFLHVDDKLAYIRVNHADKDTFSSSISTYISTDELVGSPLTVSILQESSSLRLLEVTDDDRLWLKKVMEEEEQDCKCI", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.", "AFDB_id": "AF-P38208-F1-model_v4" }, { "swissprot_id": "Q7VG37", "sequence": "MTYFDPKIQESDFALSSYDYTLPFSAIAQNPANPRERAKLLIYQRDSGRIIHSDFYHFCDFVPKDTLLVFNDTRVIKARIYAHKLDCNTQKLSDKTFEIFYHKPLQSTSSAIPLFLVQIKGRVKCGDKLLINTDSTNPFLIAQVQECLDNGLRVVSFMQNEHALEYIQVLDMLEKYGHTPLPPYIKREDSCQDAHFYQSVFSKQLGSIAAPTASLHFSKESIESIKAQFETCFLTLHIGAGTFMNVESADIRHHLIHKEFFSLSPQSAAAIQNAHKVLCIGTTSARCVEYYARYKILQGECDIFLYPSKSFKRVDYLLTNFHLPKSTLMMLVSAMVGREKCLELYKLALEKGYRFYSYGDGMLIL", "function": "Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).", "AFDB_id": "AF-Q7VG37-F1-model_v4" }, { "swissprot_id": "P98082", "sequence": "MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA", "function": "Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.", "AFDB_id": "AF-P98082-F1-model_v4" }, { "swissprot_id": "Q89B38", "sequence": "MNNNKVYSLNVVSFEKIIFNDFVKKIQVSGSEGELGIYPGHLQLLSLIKPGPLLILDDHDYQHVIYISGGIIEVQPTVVSILADTAIRGLDLDLNVVLDKKLKLENKISNVDCIDRNDVIQQLSCELAKLRVIEMFKNQYIKKNN", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-Q89B38-F1-model_v4" }, { "swissprot_id": "Q9U3K5", "sequence": "MLGFFGPLYEQLVGMLRKQQGQLAFDTIDRVNAWFTPFVLVAMTLAISCKQYFGQPIKCWTPREFSGSWDGYVHDFCFIENTYFVPNGTEVTDEARGGRHINYYRWVPLVLLFQAAMFVLPYHLWNLFHKRTTINLKGSLRFFEGALKKLEPAQACESFAGEIWNRLSDIRNSSNKLYGFQATINYFLLKLGFIVNCILQMVLLKHFLDVDDYFWGFFHLWNVEFKGTAEKEDSIFPRIVLCDFKVRNLGQQHQHTVSCIMILNMIIEKLYICFYFWLIFVFVVTTAGMIHFAFQILFRRHSLIPTNLNNKNKMNPTRSHEFIKDYLNFDGCLLLTYVDAQFGAFRTSQVIDGLVHRFTNELDSDSSAVTSLNEDHPERYVAFNTDTIPMDRYARKHHSLIEEVDGPSAPPANEEKKEI", "function": "Structural component of the gap junctions.", "AFDB_id": "AF-Q9U3K5-F1-model_v4" }, { "swissprot_id": "Q93UV4", "sequence": "MSESGGGTVATARQRQLVERALGEWQGEVAGRVIVVTGGARGIGRSLCEGLLRAGAKVVAADLTWDDADDFRKQLESDGSGMAVDMDITDDDALDAARDAVIDRFGTVDVLVNNASLVSETLFPPTGHRNTLDTTDRDWEVMFGVNVFGTLKAIRRFIEPMRAQQRGSIVNVVSSGVLAVAAGGGYHGLRPWTVEMPYQATKAAVMALTFYLAEEVRGDGVAVNAIMPGHTRASWFDATARAFNEQGIAYFMRPAIPEHLLPISLFLAAQDSAGASGRLYYVPEWNYDHGYGDYAAWQDHELPPDMEEIYSRLEAATPSYERAGVAHLPFDAQGALYAAGMANLGAQNSWTSNDSAQ", "function": "Catalyzes the dehydrogenation of both 9-fluorenol and 1,1a-dihydroxy-1-hydro-9-fluorenone to produce 9-fluorenone and 2'-carboxy-2,3- dihydroxybiphenyl, respectively.", "AFDB_id": "AF-Q93UV4-F1-model_v4" }, { "swissprot_id": "P49013", "sequence": "MKVSLLAVLLLSIVAATYGQGECGSNPCENGSVCRDGEGTYICECQMGYDGQNCDRFTGANCGYNIFESTGVIESPNYPANYNNRADCLYLVRIKGARVITFTIEDFATEIFKDAVEYGVGPVADFNQALATFEGNLTANNQVPPPFSVQGEQAWFIFSTDRNIPRKGFRITFSSDGDDCTPNPCLNGATCVDQVNDYQCICAPGFTGDNCETDIDECASAPCRNGGACVDQVNGYTCNCIPGFNGVNCENNINECASIPCLNGGICVDGINQFACTCLPGYTGILCETDINECASSPCQNGGSCTDAVNRYTCDCRAGFTGSNCETNINECASSPCLNGGSCLDGVDGYVCQCLPNYTGTHCEISLDACASLPCQNGGVCTNVGGDYVCECLPGYTGINCEIDINECASLPCQNGGECINGIAMYICQCRQGYAGVNCEEVGFCDLEGVWFNECNDQITIIKTSTGMMLGDHMTFTERELGVAAPTVMVGYPSNNYDFPSFGITVVRDNGRTTTSWTGQCHLCDGQEVLYTTWIESSMVSTCEEIKRANKVGQDKWTRYEQSFAPQPDA", "function": "Forms the apical lamina, a component of the extracellular matrix.", "AFDB_id": "AF-P49013-F1-model_v4" }, { "swissprot_id": "P55689", "sequence": "MSYDDATFAPDGTDILTWLKDLSAAEEFFDALGVTYDPKVLNTSRLHIMKRMGQYLVAEDFSDLPTGTAATRARAALERAYRDFATSSPLKHRVFKVLEDRDPTKAAAPIQVFVPLEELLQPSEISDCGGVATQRCHQSDKVVAAPDALE", "function": "May protect the nitrogenase Fe-Mo protein from oxidative damage.", "AFDB_id": "AF-P55689-F1-model_v4" }, { "swissprot_id": "Q9UIU6", "sequence": "MSSSSPTGQIASAADIKQENGMESASEGQEAHREVAGGAAVGLSPPAPAPFPLEPGDAATAAARVSGEEGAVAAAAAGAAADQVQLHSELLGRHHHAAAAAAQTPLAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPSETQSKSESDGNPSTEDESSKGHEDLSPHPLSSSSDGITNLSLSSHMEPVYMQQIGNAKISLSSSGVLLNGSLVPASTSPVFLNGNSFIQGPSGVILNGLNVGNTQAVALNPPKMSSNIVSNGISMTDILGSTSQDVKEFKVLQSSANSATTTSYSPSVPVSFPGLIPSTEVKREGIQTVASQDGGSVVTFTTPVQINQYGIVQIPNSGANSQFLNGSIGFSPLQLPPVSVAASQGNISVSSSTSDGSTFTSESTTVQQGKVFLSSLAPSAVVYTVPNTGQTIGSVKQEGLERSLVFSQLMPVNQNAQVNANLSSENISGSGLHPLASSLVNVSPTHNFSLSPSTLLNPTELNRDIADSQPMSAPVASKSTVTSVSNTNYATLQNCSLITGQDLLSVPMTQAALGEIVPTAEDQVGHPSPAVHQDFVQEHRLVLQSVANMKENFLSNSESKATSSLMMLDSKSKYVLDGMVDTVCEDLETDKKELAKLQTVQLDEDMQDL", "function": "Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis.", "AFDB_id": "AF-Q9UIU6-F1-model_v4" }, { "swissprot_id": "P23595", "sequence": "MDMEIDDPMHGSDEDQLSPTLDEDMNSDDGKNNTKARSNDEDTDEELEDFNFKPGSSGIADHKSSKPLKLTNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRPGEPTVTRKTPDYFL", "function": "Exact function not known, phosphatase 2A performs an essential cellular function.", "AFDB_id": "AF-P23595-F1-model_v4" }, { "swissprot_id": "Q8PYJ4", "sequence": "MEIRMSKSSSKPVLVTCGLPYANGKAHIGHLRTYVPADIYARSLKKEGREVTFVCGSDTHGTPIVVNAEELGITPTELVEIYHKHFDETFKQLGIYFDAFGTTDDPENHNRTHDIVSRLIEKGYVYPKIIEIAYCPACNRFLPDRYVEGACPHCGETARGDECDQGCGKHLEPGELQNPVCTICGGPAEYRQQEHFFFKLSEFSNYLMDYLSKDLGGTTNAINYARGWVKQGLTDWCITRNLEWGVKFPGHEDLVVYVWVDAPIGYIAFTEEWAAQAGDSWEKFWKGDGEIVHFIGGDITYHHCIFWPAMLKGADYSVPTAVVASGMVKIEDRKFSKTRGYVVWVGEDYLDHGFHPDLLRYYLASYTSHTKELNFSWRVLQEKINAELVAVLGNFLYRTMLFAFKNYGEVPEGEVEPEIRKEIEKALVEVKAAMEEYEFKKAVDSAMALASFGNTYFQSHEPWKLIKEDRDACGQVVYNCLHLAKALSLIFEPVIPQTMEKAWKGLGHESDIHAALYEETLVPLKAGTKLAKPEILFTKLEDDRIGEMEEIANQRVAAANAKRNGVKGGEKEPSKSEGMGPSEASKASEKTVDVATAEEKVQVETLPVIDYEDFAKLDIRVGKVLLVEPVKKSKKLLRIEVDIGEEKPRQLVAGMASYYTPEELVGKSVIVLANLKPAKLCGVESNGMMLAADDGGAIVAALMPDKEIKSGSRIR", "function": "Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.", "AFDB_id": "AF-Q8PYJ4-F1-model_v4" }, { "swissprot_id": "Q54C30", "sequence": "MINRKPTRIELNMEDIEEYEQLKKEQTNSYKQQQQQQQPTTISTPKQYPLLNTTQPPKKTTAQIIGYDQ", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.", "AFDB_id": "AF-Q54C30-F1-model_v4" }, { "swissprot_id": "O60152", "sequence": "MLQDESSRSLPRSALIRRRLSLFLQSHALMYSFLWSESAKKSLLNEVFSALLGYDHTLWNTLLPERPTIDASFLLRRAQGHSEGDEYRHGTCESKCGHIFRKGEVFYRCKTCSVDSNSALCVKCFRATSHKDHETSFTVSAGSGGCCDCGNAAAWIGDVSCKIHSHEEDATISNDMIDEIPEKLENSIQTTIDCVLDFVLDVFSCSPENLKKMPTLESILQDEKTSRLSENKYGDIDDSCNMYSLVLWNDEKHSFKQFYEQITTALELPNNVFGKKMANIINDIGRACIVTETNIKELLKIGQKLAQINLAVSIRSMRDIFREESCAVLLEWLADIAGSSICGKRNYFSSVICKELVRPWNCGLHNSDLTFRLSLRSLALPEIVAIDSPDIFLNEDHINSSGPSDTSSHMLETDESSIHSRHWYPSNSLPDVLSYASRVRFDYFFLYDLKLWKSLRYKLQELYLGYFITQPGFKEIMGARIAISYRRLAELFLLLDREPEHSVIFFSMQIFTVADVAKLLVTEYDFLTTINATLYTFFTYKKLNTPNYVDQHAMIRTDSAAFHSRRYIHIFHHIQFMLSIPCVAEIVREDLKFLKQYADFFNLFQGMCPYTRAVSQHVEWENDSWMYVLNVSLQVAKLCRHVGNVFMELNTNKLANAINYLISLILYPKARNESWTNTESLTTGITVDERGNSKLIEYDIALQPVSFHHPLHWLLVYLLSFYVERDNYKLLWTQLDLLAVTDHPLRVCAWLSQMRAKLWIRNGTTLRDQAHHYRNLSFHEYTFDLDVLLLQLTLTYGDPDAILPSFISRFQLEDQMYGRFFVPHKHYDVSQVTIMMEEFLLLLISIVCNTAVLDHWDITRRIEYGIAHILCFRPLPYSEITKRTCEHLLEHKQFESTLKKVATFRNAEGINDSGSFTLKDEYFDYVDPFNIHYSRNQREEAENILRRRYSKQHSKHLESVVYEEYHPILHSNITIPILQSDSFVGILWHTIVYAYIYPYDQGKLEGLVNTALHACLLVLMSEKGSEPIFSKKICENRFPVVEGLQEYCNSPDVTLFSVLCQMKNHRNFVYVKEKISLIMKILKSEVPLLYEPVYAETLSISSSKIVQSLSDAEQQEQHLAKVRMAKERQARIMEQFRMQQNKFLENHALFEASDCEMDEADEFSVTSSVSTKLFLDPPIDTCLLCQEELKDKRPYGTLVFVLRSSVLRLFPADDANYVSEVLDIPDSLDHEIQERPFGLAGKRKKVLDSTEAYDYDNYYYEKKGNELHQLKDSFNGFPPDQLDRGLHATGCGHFMHIDCFKNHIATVTLATRANPYRNHPHNLSMKEFLCPLCKALCNTIFPILWRPKEEINFQEAGVLTAPLKNWLVSKTFSFNKDLNQQLLDIETSPSEHTQSYNLNLLDVLQHTLRDSLKDIYTLNTGADNSSDNVEENADNLFQSSVLDHVHFKSVVNNEVPADERLAISDDIFELYRRLDDVIDLNSSLYSDDFIPVNGKLHNVVKLFSYSLCQVEASTRGHIKCSSIPADIWVHNLGKNQQVFLRILSESIKTYTLLCAHDSQKRIGGSIQEFEFISFCQQKRIFGRLLPSLDSPVTKSITDDRVEPLLVKDTFREFAEASVSGLLSCDESFHYLTQLYYTADIVRNLWILLSQRNSLLKCMESVEFEAFDYEQLKGFEHLVIQIWKSLRVDGAGLINFDCCTEDDLNNPHLLFTLYKLLERFSLIFLRKCALLWYCRYGVSFETQPNLNFQNSELSRLQTKMHIPGVIELSNHLCLTASSTEWSLIKHWCNFFTETGPLCDFPRAYYPGIYELVSLPYELDKVFELLLARRCSKCLTEPMEPAICLFCGKLLCFQSHCCSFNGIGECNLHMQQCASDIGIFLIVKKCAILYLNPPVGSFSVAPFLDAYGETDLGLRRGRSQYLSQKRYDETVRTMWLNGSIPSYIARQLDANPDTGGWETL", "function": "Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.", "AFDB_id": "AF-O60152-F1-model_v4" }, { "swissprot_id": "F1QG30", "sequence": "MSLRESPFPNGFLEGLHAVGWGLIFPCFWFLDRLIAVCISTTLERMWRLEQECYLHPLKVVFGSILFFILFVISTPFALLGFILWAPLQAIRRPFSYHKQEQSIPMENRNARWEEMGKISFGFLTANVCLLPDGIARFNNLGHTQKRALIIGKSIVQGVTRPHIRIFVDSPSSCGTVTPSSSLIPQPNASSYGSVDASGELPDAIEVNEITPKPNCNQNSNHQKHPPRSLRTLLRDADIPMEVSALFPPSVDIVCLQEVFDKRAARKLTQALGPLYGHVLYDVGVYACHPAGSCSSFKFFNSGLFLASRFPIMEAEYRCFPNGRGEDALAAKGLLTVKVDIGLQKGEKRMVGFINCTHLHAPEGDGAIRFEQLNMLSKWTSEFQTLNRRDDELPLFDVLCGDFNFDNCSPDDRLEQSHSVFDEYTDPCRAAAGKEKPWVIGTLLEQPTLYDENMRTPDNLQRTLESEDLRKDFISPPVALDGVPLVYPEADQPWIGRRIDYLLYREKSGHRTEVEELTYVTQLAGLTDHIPVGFRLSVSLDSEQN", "function": "Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide.", "AFDB_id": "AF-F1QG30-F1-model_v4" }, { "swissprot_id": "Q9UJT2", "sequence": "MASVVVKTIWQSKEIHEAGDTPTGVESCSQLVPEAPRRVTSRAKGIPKKKKAVSFHGVEPQMSHQPMHWCLNLKRSSACTNVSLLNLAAMEPTDSTGTDSTVEDLSGQLTLAGPPASPTLPWDPDDADITEILSGVNSGLVRAKDSITSLKEKTNRVNQHVQSLQSECSVLSENLERRRQEAEELEGYCIQLKENCWKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQEPEEKQEPEEKQEPEEKQKPEAGLSWNSLGPAATSQGCPGPPGSPDKPSRPHGLVPAGWGMGPRAGEGPYVSEQELQKLFTGIEELRREVSSLTARWHQEEGAVQEALRLLGGLGGRVDGFLGQWERAQREQAQTARDLQELRGRADELCTMVERSAVSVASLRSELEGLGPLKPILEEFGRQFQNSRRGPDLSMNLDRSHQGNCARCASQGSQLSTESLQQLLDRALTSLVDEVKQRGLTPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKMATLDHLHLKMCSLHDHLSNLPLEGSTGTMGGGSSAGTPPKQGGSAPEQ", "function": "May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.", "AFDB_id": "AF-Q9UJT2-F1-model_v4" }, { "swissprot_id": "Q9I737", "sequence": "MALAQQTRLVRVDSPLGAEVLQLQRMEGREELGRPFAYELELISENPDLPLDGLLGKPASLALELHDGSRRHFHGIVAACSQGSGNGQFASYQVTLRPWLWLLTRTSDCRIFQNQKVPDIIKQVFRDLGFSDFEDALSRSYREWEYCVQYRETSFDFVSRLMEQEGIYYWFRHEQSRHILVLSDAYGAHQSPPNYASVPYYPPTLEQRERDHFYDWHMAREVQSGSLSLNDYDFQRPGARLEVRSNIARSHAAADYPLYDYPGEYVQSQDGEQYARTRIEALQARYERVRLRGRARGLGSGHLFKLSGYPREDQNREYLVVGAEYRVVQELYETGGGGVGAQFESELDCIDAGQAYRPLPTTPLPIVRGPQTAVVVGPKGEEIWTDQYGRVKVHFHWDRHDQSNENSSCWIRVSQAWAGKNWGSMQIPRIGQEVIVSFLEGDPDRPIITGRVYNAEQTVPYELPANATQSGMKSRSSKGGTPANFNEIRMEDKKGAEQLFIHAEKNQDIEVENDETHWVGHDRTKTIDHDETVHVKHDRTETVDNNETITIGVDRTEKVGNNEKISIGANRTEDVGSNETISIGVDRTEKVGSNEKISIGANRTEDVGNDETISIGANRSESVGNNETISIGADRSESVGANETIDIGGNQSTSIGKNESRSVGQGRDTSVGKDDSLDVGKSFTLNAGDSITLVTGAASIRMKKDGSIVISGKNITIDGSGAINVKADKNVVVKGRKILQN", "function": "Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse7 toxin to target cells where it exerts toxicity through its nuclease domain.", "AFDB_id": "AF-Q9I737-F1-model_v4" }, { "swissprot_id": "Q94A87", "sequence": "MDVSALLTSAGINIAICVVLVSLYSILRKQPANYCVYFGRLLSDGRVKRHDPRWYERFAPSPSWLVKAWETTEEEMLAAAGLDAVVFIRMVICSIRIFSIVAVVCLAFVLPVNYYGQKMEHKEVHLESLGVFTIENLNPRSRWLWVHCLSLYIISSAACALLYFEYKNIAKKRLAHISGSASKPSHFTVLIRAIPQSPDQSYSETVSKYFTNYYAPSYVSHLMVYRDGFIHRLMNETERMCQAIKHVSPDLSCNPSLKSCVLCGPAATNSFQIISNETDSVKGLELGELTLTTTEEERPVAFVFFKSRYDALVVSEVLQTPNPMLWVADLAPEPHDVHWRNLRIPYRQLWMRRIATLVGAIAFMFVFLFPVTFVQGLTQLPTLSKNFPFLKDLLNRRFMEQVITGYLPSVILVLFFYTVPPLMMYFSTLEGCVSRSQRKKSACLKILYFTIWNVFFVNILSGSVIRQFTVLNSVRDVPAQLAKLVPAQAGFFMTYCFTSGWAGLACEIMQPVGLIWNLIAKVIVKNKEESYETLRFPYHTEIPRLLLFGLLGFTNSVIAPLILPFLLIYFFFAYLIYKNQIINVYITKYESGGQYWPVFHNTTIFSLILSQVIALGFFGLKLSTVASGFTIPLILLTLLFSEYCRQRFAPIFQKYPAEILIAMDRADEMTGKMEEIHNNLKVAYSQIPTCSEESSKAGCTSPCSDQELPDSEELKPEKENLKADYIWEFQRSKSGLDLEVKSCPSASPIRNSPGFAEIYKRT", "function": "Acts as an osmosensitive calcium-permeable cation channel.", "AFDB_id": "AF-Q94A87-F1-model_v4" }, { "swissprot_id": "Q54S31", "sequence": "MSNVQSQSNSHHPVHNIVNRSPTSRSEQQIRSIPPTNNNNNNNNNSINNINNNTQRQPLNNNNNNNNNINRNNSNLYPSYADQPDILRSSQKDEYYKKLFEDQCFEMLTRITGPRFIMNRQSESKLLANTIYYLLTTMIGSQTLGEEYCNLRKIKDKTFSIPSIPDRIKLYFFHLLAPYLIKKSLPKLFQRHPKLYILKEIFPKFERLHLALFYFNGSYFEFSKRLSDIRYIFNRKIDQKRPKYDILGLLIIIQILLSTFMYLKENSFFLKQQQKDGGCNGDGEEDNQDLNKDIKIEQVDSVINNNNQDQNNNQEEEEEQKCTLCLEVRTHTTATICGHLFCWHCITEWCNNKEQCPVCRCPISIRTCVPLYNY", "function": "Involved in the biogenesis of peroxisomes.", "AFDB_id": "AF-Q54S31-F1-model_v4" }, { "swissprot_id": "Q9SF29", "sequence": "MTVIDILTRVDSICKKYDKYDVDKQREANISGDDAFARLYGAFETQIETALEKAELVTKEKNRAAAVAMNAEIRRTKARLSEEVPKLQRLAVKRVKGLTTEELAARNDLVLALPARIEAIPDGTAGGPKSTSAWTPSSTTSRPDIKFDSDGRFDDDYFQESNESSQFRQEYEMRKIKQEQGLDMISEGLDALKNMASDMNEELDRQVPLMDEIDTKVDRATSDLKNTNVRLKDTVNQLRSSRNFCIDIVLLCIVLGIAAYLYNVLK", "function": "Vesicle trafficking protein that functions in the secretory pathway.", "AFDB_id": "AF-Q9SF29-F1-model_v4" }, { "swissprot_id": "A2BJ90", "sequence": "MSRSARRKTSALNTVLRVVEVFASIQGEGPFTGTYSVFVRLAGCNLRCPFCDTRYAWSLEAGKPLGVEELVEEIARYEPSLVVITGGEPLLQRHPLNSLVEGLESLGLRVQLETNGILPAPARDEQLWRVYHVVSPKDVPVRVPGAKLHPSWVDYARATGRAWFKFLVANEQHVREVAEYVAKLGIPRSRVYIMPLTPEKLDMKELLELHSRIASLAVKWRLNFSPRLHLLVQLP", "function": "Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.", "AFDB_id": "AF-A2BJ90-F1-model_v4" }, { "swissprot_id": "Q96GE9", "sequence": "MGSRLSQPFESYITAPPGTAAAPAKPAPPATPGAPTSPAEHRLLKTCWSCRVLSGLGLMGAGGYVYWVARKPMKMGYPPSPWTITQMVIGLSENQGIATWGIVVMADPKGKAYRVV", "function": "Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.", "AFDB_id": "AF-Q96GE9-F1-model_v4" }, { "swissprot_id": "Q795K2", "sequence": "MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGMLLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKEKTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIELEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTKLEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVISPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGNGLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE", "function": "Member of the two-component regulatory system YvfT/YvfU. Probably activates YvfU by phosphorylation.", "AFDB_id": "AF-Q795K2-F1-model_v4" }, { "swissprot_id": "P52957", "sequence": "MEPPAISQQSTPTAPGGTQGTRKLRESCISCSRSKVKCNKEKPTCSRCVRRGLPCEYMVSRRTGRTRVIGVEQPKTAPSPTTPTNTTAATTATKAGPPVTTDSAVHTPVITTAPSPKPVQIQSPPAEPDLWGAILSPNTSTSTDLSSLLSVNTNFSQLFASLSPSLLEGMDGMDAEMHAPELGALSVADPSSSMMQGLEAPNAAQPPSSNTTSHSYCLSICLDTLMRLFPNAGANCERPGHESNPGKLFTIESVIEDNKQILDTAQTILACRCAEDEYVVTLVSLIVFKVLGWYVAAARDRSSDPGREEDFNWSTAQDSRRGSVSSFEEQVLHLPTVVGSYCIDGHHQSRMAAQLVLSELYRVQRLVTQVSRRLESIRRRSSSSSSSASSNTTDSDGGMSTPLSSTTLVHLEDDLRKRLRAVSSETISILRHA", "function": "Transcription factor; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins. Binds to the palindromic sequence 5'-TCG(N5)CGA-3'found in the promoter regions of several sterigmatocystin cluster genes to induce their expression.", "AFDB_id": "AF-P52957-F1-model_v4" }, { "swissprot_id": "Q65RN5", "sequence": "MDLNTILIILGILALVALVAHGLWSNRREKSQYFENANTFGRANRQDEPISTPESYKQARNVAPAFTQPKQAVIHQEPPVQQPLNTEPEPITQETPVRAEPQSVDQIKITLPNVEPAPAESAPIYEMRPSRRNTEPQYYQQPSEPYYQQPVQQNLARQTIADIEATVDPNEGVNSSSEYLRTQLQEASQEGNQIFTQSPLSRAPLQQPIEFDQPAQQEKESDNNEDEDVSFVMLYVAAAENRQFQGTVLVQALEDLGFSLGEDNLYHRHLDLTVASPVLFSAANITQPGTFNPYTLHEFFTDGVAIFMRLPSPGNDRTNLKIMIRSAKTLAQQLGGFVLTEQQELFTDAAEEEYLAKIK", "function": "Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.", "AFDB_id": "AF-Q65RN5-F1-model_v4" }, { "swissprot_id": "Q54E35", "sequence": "MESVTTTIQCMGIKDSCNKKKIFQGGKSKIIEFQVKYENSDEVLNFQTTQSAINKLISELKKEIYSINLPISNYSVTSSSALQDINLLCQCISSTPKIQRSLSFVNFIETENNLTVSSTFIFDFIKNSDISGVLLKTKNNNKRTKKERLCVIKYSRVLYYFSETGGGSSTDINSTEVKKKRCKGLKFLDDCKITEKGENYFQLKTSNNETYVFTTPTNDECDRWVTTINNCIDYITKSTYRVSGQVQGTVVKSRNLAAKDLNGKSDPFVIIKAEQQQHRTQTIYKSLNPQFNEAFHFDITKHQGYVYFFVWDEDKFKTADFMGEVAVPLSLLPPNGSEISLWLPLSPRNSKDKVSGDILIKIRYFFSPDQIEVSPTSIYGNSLEAIVKNRPEICKNQVPNILYQFIEFFEQHLNEEGLFRICGNSTEIKFIKNQVNTDTQITFNPSSVHAYAGAFKLFFRELPEPLFTFNQYDNLINLAKKSTELQPLIEIIKTFPICHLNVLKLLLPFFGKIAANSKSNLMNHSNLSIVFGPSFLRVKDESHVNLMEMILVNDIAKFVFENSQQILKSI", "function": "Rho GTPase-activating protein involved in the signal transduction pathway.", "AFDB_id": "AF-Q54E35-F1-model_v4" }, { "swissprot_id": "Q73JU8", "sequence": "MDTDKLLSKDLLSNGILLKGLKELGINEKAHNKLSKLLNIYMRELKMFNASFNLVKVKDDEELIVAHILDSLSAWRFFYNETKNTESKTSLNNAETKNTNEALLTSEPFYIADAGTGAGFPGVPLAALFISLGNLDVKLSLIERMQKRCTFLENIKAVLQLNNTEIIESEAEKAPQNKFDIVTCRAFHTLDKHILQTLLNLAKPKGKLFLYKAAKEKINEETELIKKEGLNYKTEKLDVPFLKKERHLLIIEKP", "function": "Specifically methylates the N7 position of a guanine in 16S rRNA.", "AFDB_id": "AF-Q73JU8-F1-model_v4" }, { "swissprot_id": "P03030", "sequence": "MAAVNLRHIEIFHAVMTAGSLTEAAHLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPQLLQPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERTELLSLDEVCVLPPGHPLAVKKVLTPDDFQGENYISLSRTDSYRQLLDQLFTEHQVKRRMIVETHSAASVCAMVRAGVGISVVNPLTALDYAASGLVVRRFSIAVPFTVSLIRPLHRPSSALVQAFSGHLQAGLPKLVTSLDAILSSATTA", "function": "This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression.", "AFDB_id": "AF-P03030-F1-model_v4" }, { "swissprot_id": "Q9EQR5", "sequence": "MRPPVPSAPLALWVLGCFSLLLWLWALCTACHRKRAQRQQTGLQDSLVPVEMPLLRQTHLCSLSKSDTRLHELHRGPRSSIAPRPASMDLLHPRWLEMSRGSTRSQVPNSAFPPRQLPRAPPAAPATAPSTSSEATYSNVGLAAIPRASLAASPVVWAGTQLTISCARLGPGAEYACIQKHKGTEQGCQELQQKAKVIPATQMDVLYSRVCKPKRRDPRPVTDQLNLQDGRTSLPLGSDVEYEAINLRGQDMKQGPLENVYESIKEMGL", "function": "Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.", "AFDB_id": "AF-Q9EQR5-F1-model_v4" }, { "swissprot_id": "P19121", "sequence": "MKWVTLISFIFLFSSATSRNLQRFARDAEHKSEIAHRYNDLKEETFKAVAMITFAQYLQRCSYEGLSKLVKDVVDLAQKCVANEDAPECSKPLPSIILDEICQVEKLRDSYGAMADCCSKADPERNECFLSFKVSQPDFVQPYQRPASDVICQEYQDNRVSFLGHFIYSVARRHPFLYAPAILSFAVDFEHALQSCCKESDVGACLDTKEIVMREKAKGVSVKQQYFCGILKQFGDRVFQARQLIYLSQKYPKAPFSEVSKFVHDSIGVHKECCEGDMVECMDDMARMMSNLCSQQDVFSGKIKDCCEKPIVERSQCIMEAEFDEKPADLPSLVEKYIEDKEVCKSFEAGHDAFMAEFVYEYSRRHPEFSIQLIMRIAKGYESLLEKCCKTDNPAECYANAQEQLNQHIKETQDVVKTNCDLLHDHGEADFLKSILIRYTKKMPQVPTDLLLETGKKMTTIGTKCCQLGEDRRMACSEGYLSIVIHDTCRKQETTPINDNVSQCCSQLYANRRPCFTAMGVDTKYVPPPFNPDMFSFDEKLCSAPAEEREVGQMKLLINLIKRKPQMTEEQIKTIADGFTAMVDKCCKQSDINTCFGEEGANLIVQSRATLGIGA", "function": "Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.", "AFDB_id": "AF-P19121-F1-model_v4" }, { "swissprot_id": "C5E0N8", "sequence": "MLRTACSRSHVFKAFSSSLMLEHALAAANSSGAAAPTNAASTGNSHDSTLKSELPLRTLNDELHNAERKYIKPLTNAPEWSSTRTGPNSKIREYLKNGQYTKLLIRLSVDNHLNNEYISGLFTTGGLTKSEYSLFINKLLSEEELDVKLSNVIPDTPHTELIYKLYEFYCDHIVDQHNLTPLQLYDLNLFLKTFIAEAQLSKAHNVLDFILLRRPLNDLLANTDVEILIQFLRLKCGALSKFWKIQPASQRNSTAITLGEKASDCHLAKSYKFQNEKVLLQIINSVLGEHNWKNRRSPKLDAAIIYSLGYLGQTDLIEKYVNRTWSPSKDEGVKTNPNSDLLVAVLTSYCVKEGNMRKGLEVLDRFIRDYPEVELDPLFWRRLLQLSSLLWDKKRDRKATLSHGCWTIMKQWHAQRQRKIPYDYGIMKELYPIFVRTKNKNGALEVITKSFFGAFIQPEFTIRPNELSLLCKYQRFILKMIALKGNYHKGFEFCQEWSFSSTNKFELQSYFMKWRGIHEQRRTSQSKQKAALQEKYDEMEEDDMLLGRLW", "function": "Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.", "AFDB_id": "AF-C5E0N8-F1-model_v4" }, { "swissprot_id": "Q05140", "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMVPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVADEVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDIFATASAAAPVSSAKPSSDLLDLQPDFSGARAGAAAPVPPPTGGATAWGDLLGEDSLAALSSVPSEAPISDPFAPEPSPPTTTTEPASASASATTAVTAATTEVDLFGDAFAASPGEAPAASEGATAPATPAPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSAPVVTPTASTAPPVPATAPSPAPTAVAATAATTTAAAAATTTATTSAAAATTAAAPPALDIFGDLFDSAPEVAAASKPDVAPSIDLFGTDAFSSPPRGASPVPESSLTADLLSGSGFHCAEDDRHVPLFFTAVDAFAAPSPASTASPAKAESSGVIDLFGDAFGSSASETQPAPQAVSSSSASADLLAGFGGSFMAPSTTPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSGDLLMPTMAPSGQPAPVSMVPPSPAMSASKGLGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVTPATWSAGVPPQGTVPPTSSVPPGAGAPSVGQPGAGYGMPPAGTGMTMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPATQSPKKPPAKDPLADLNIKDFL", "function": "Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats.", "AFDB_id": "AF-Q05140-F1-model_v4" }, { "swissprot_id": "Q24325", "sequence": "METQPEVPEVPLRPFKLAHQVVSLTGISFERRSIIGVVELTIVPNSENLRLIRLNAKQLRIYSVVLNDVCQADFTYFDPFQNICYKEHKSRALEVYSKHHLTAAQYTDPDVNNGELLIQVPPEGYSMIQEGQGLRIRIEFSLENPKCGVHFVIPPASTDEETQMNSSHMFTNCYENSSRLWFPCVDSFADPCTWRLEFTVDKNMTAVSCGELLEVIMTPDLRKKTFHYSVSTPVCAPNIALAVGQFEIYVDPHMHEVTHFCLPGLLPLLKNTVRYLHEAFEFYEETLSTRYPFSCYKQVFVDELDTDISAYATMSIASVNLLHSIAIIDQTYISRTFMSRAVAEQFFGCFITSHHWSDTWLAKGIAEYLCGLYSRKCFGNNEYRAWVQSELARVVRYEEQYGGIILDCSQPPAPLPVSGTNQSAASSKQQEIVHYFPIKSLHTVSPKYVEAMRRKAHFVIRMLENRIGQELLIQVFNKQLALASSAATTKIGAGLWSQLLISTNIFIKAIFTVTGKDMSVFMDQWVRTGGHAKFSLTSVFNRKRNTIELEIRQDYVNQRGIRKYNGPLMVQLQELDGTFKHTLQIESTLVKSDITCHSKSRRNKKKKIPLCTGEEVDMDLSAMDDSPVLWIRLDPEMILLRDLIIEQPDFQWQYQLRHERDVTAQFQAIQALQKYPTNATRLALTDTIESERCFYQVRCEAAHSLTKVANQMVASWSGPPAMLNIFRKFFGSFSAPHIIKLNNFSNFQLYFLQKAIPVAMAGLRTSHGICPPEVMRFLFDLFKYNENSRNHYTDAYYRAALVEALGETLTPVVSVAIHGTQITTDSLSTDAKLVLDEVTRLLNMEKHLPSYKYMVSVSCLKVIRKLQKFGHLPSLPHIYRSYAEYGIYLDLRIAAMECLVDFVKVDGRSEDLEHLITLLETDPDPAARHALAQLLIDNPPFTRESRSRLDKPNLVDRLWFSINRLPYDTKLRCDIVDLYYALYGTKRPNCLQAGENQSFYKDLMKDNNSSVGSVTGSFKKTSDSKSHLPTPTNTLDNEPQERQKPAMVTIKRTATEAFEVGDEIIKLERSEEITVLDEPVNVQAYDSETKVNALQADEEARDTHQAAKRLKNEMYAEDDNSSTMLDVGDSTRYESSHEEGKLKSGDGGLKKKKKKEKKKHKHKHKHRHSKDKDKDKDKERKDKDKRDPHISRLQARETATPDTLSSEDSSNSNSLPPMNLN", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. An essential subunit binds to core promoter DNA.", "AFDB_id": "AF-Q24325-F1-model_v4" }, { "swissprot_id": "G5EEP3", "sequence": "MGAGLVSACLPISYVLLVHLFDRNGTDRNDPESVKRRFKGALLSNFVSIVVTAFYLRDYTDSPMLEMGVRWDNIGQSITYPFILMNAFYLGQFVMMQIDRTLWHYFDWYEWKLCFNSWVWRRDIIVGPITEEIVFRACSSTLMAHVYGPTMTILLNPIPFAASHFHHIWDDQRRGYSLAHSILQRGFQFCYTYLFGAFATWLQLTTRHAIVPIIAHAFCNAQGLPLWLEIPNYPKRRDRLTLYAAYSVGFAAFVHLLYTRNGMPTP", "function": "Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins.", "AFDB_id": "AF-G5EEP3-F1-model_v4" }, { "swissprot_id": "A1Z9X0", "sequence": "MQKMPSQILNDGSSVSLNSASMNMANTPNSITVKTAYNGQIIITTINKNISYEELCYEIRNICRFPLDQPFTIKWVDEENDPCTISTKMELDEAIRLYEMNFDSQLVIHVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV", "function": "Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization. Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins. Involved in symmetric adherens junction positioning during embryogenesis. Required for polarization of the spermatid cyst which is necessary for sperm differentiation. Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity. Plays a role in memory enhancement.", "AFDB_id": "AF-A1Z9X0-F1-model_v4" }, { "swissprot_id": "Q9V776", "sequence": "MWIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSGDLYALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPKQAEEYFIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITYQYEADKELGAHLQNELAAHADVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPYILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLNTRKPLINLEDGIALTLMPLGVIEPGNEERAV", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9V776-F1-model_v4" }, { "swissprot_id": "Q2SDQ4", "sequence": "MLAEQFTDKNKHAEQELSPGSSAVTGARNWRASLTLNLTKESNRTILKQAAHQGPLRVQRPFYPEGAQRPHIYILHPPGGLVCGDEIEIDAKLEHGAEALLTTPSAGKIYRTDAAGHRQCQTVRLNCADAQSLEWLPQENIIYDGAEGAQTLLLETSAASRFIAWEITALGRPAADAPFASGAFTQTTRILRDSAPCFFERVALRGEGPGFQEPWGLQGQQVYGSLLAGYVQDSPQKRLQQCREALQANTAIAALGDSKDLRWTLTRKDDLIILRALCQQSEPIKRLFMAAWSLLRPALIGVESHPPRIWAT", "function": "Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.", "AFDB_id": "AF-Q2SDQ4-F1-model_v4" }, { "swissprot_id": "Q3IK52", "sequence": "MEDFNFGRELRLLTPSHYSRIFNEPARAATPFFTLLAKPNDQDQPRLGLTVAKKRVKKACQRNRIKRLARECFRLNKHNIDNIDIVLMVKSGIDEQSNEELTKQLTKLWRKINERCKPGAPKPPPFKKRPNKSVKSNKQT", "function": "RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.", "AFDB_id": "AF-Q3IK52-F1-model_v4" }, { "swissprot_id": "P9WPJ8", "sequence": "MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV", "function": "Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.", "AFDB_id": "AF-P9WPJ8-F1-model_v4" }, { "swissprot_id": "P53838", "sequence": "MSNESTRVTVSRGCTASDECAQALERTNDELDRESSVSESRSDEESHEKLSRRRFPTLGIGIWLDLKDRIPYYKSDWVDAFNYRVIPSIVDTYFNNLLPAIAFAQDMFDRTDNSYGVNEVLLSSAMAGIVFGVLGGQPLCIVGVTGPISIFNYTVYEIIKPLNTSYFGFMFWICMWSMIFHLVLAFTNAVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFSAKSGEKSVQDGFASVVVALVMTAFGLFFKLFHYYPLFSHRIRTFISDYSTALSVLFWSSFTHFGGYLHDVKFKKLPITKAFFPTSKVNRPQNTWLAYEPIPVKDVFIALPFGIFLTILFYFDHNVSSLMAQRHQYKLKKPSSFHYDFALLGLTTCISGVLGIPAPNGLIPQAPLHTETLLVRDSNQKVISCVEQRFTNTFQGLMILGTMTRPLLVCLGEIPQAVLSGLFFIMGINGLMTNSIIQRLVFLFSDPNRRDNTSPLMKVSKKSMLIFLSFSLTGFAGEFAITNTIAAIGFPLVLLLSVLVSFSFAYIFPTEELKILDTNVAQKFTIKNLLLENIRDAKFCDKHED", "function": "Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole.", "AFDB_id": "AF-P53838-F1-model_v4" }, { "swissprot_id": "Q8INB9", "sequence": "MNYLPFVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSGSAEKFSWQQSWPSRTSAAPTHDSGTMSINTTFDLSSPSVTSGHALTEQTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSYQGDMASTLGTSSHISTSTSLASMQ", "function": "Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex. Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth.", "AFDB_id": "AF-Q8INB9-F1-model_v4" }, { "swissprot_id": "Q08630", "sequence": "MGLYRPSKFFHPPIPHIPFTINPDFFSFHIQRLKAKANPENFLICFPPPDIYKGFVFCCQLDLVHLFSYVFFLFLLKICVDVLQYVIYPKHFTHKKPGFENYSI", "function": "May be involved in a pathway contributing to genomic integrity.", "AFDB_id": "AF-Q08630-F1-model_v4" }, { "swissprot_id": "Q9VWV8", "sequence": "MTRHARNCTAGAVYTYNEKKRDAAESGYGTNAQRLGKDSVKSFDCCSLTLQPCRRPVITKDGYLFDKEAILQYIVTKKNEYSRRLKEYERLRRAEEDKLSQEANSKQQARMERFVNAEKPAMTPAHSSAAASEKPSTSSAAAAASSESSSASSISNMTNGHEKKLPSFWLPSECPNAGLAKAQKPDATIYCPVSQKPLRVKDLIDVKFTLLKDGDTKRSLIAKEARYMCPITHDVLSNAVPCAVLRPTGDVVTMECVERLIRKDMIHPLTDRKLKEKDIIPLQRGGTGYATTNDHLQAKEKRPMLQA", "function": "Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.", "AFDB_id": "AF-Q9VWV8-F1-model_v4" }, { "swissprot_id": "Q7ZW16", "sequence": "MGYDVTRFQGEVDEDLLCPICSGVLEEPVRAPHCEHAFCNACITQWFAQQQICPVDRTVVTLAHLRPVPRIMRNMLSKLQISCDNAGFGCTATLRLDQLQSHLKDCEHNPKRPVTCEEGCGLEMPKDEMPNHNCIKHLRSVVQQQQTKIADLEKTAAEHKHQLAEQKRDIQLLKAYMRAIRSANPNLQNLEESIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLIDSGCPLSIVNDLIENAHERNWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGEDMILEPGLVMIFAHGVEEIL", "function": "Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins.", "AFDB_id": "AF-Q7ZW16-F1-model_v4" }, { "swissprot_id": "Q9RU24", "sequence": "MKKVMMLALALGASTSLAAPFVYPANWTSNKPGDVQTGGTFRSVNLQDFKTLNPFVSSESPNLPAVLSAGSLLGYNPVTGNYAPYMAEKYTQSADKRTFTFDIRKGMKWSDGKPITVDDWITAYTIDSNKDVGSNTFDYWTINNQPIKVTKVDSNTLKVVFPKADVTAIEFLSGIFLPQPTHVFMPVWKAKGAQGIKDMWTISTNPDNIVTSGPFMLDRYVRGERAILKKNPYFGEWNKDSAGKSLPYLDGIQINIVADANAQLAQFLAGNLDTYSPDNRDKLAQVKSAMDGGKVKGTLIPNASARASSDFMVFNMDDSATFKTKLFSNVKFRQAMSMLMNRDAMVDLALGGLGEPTYTSVYPVYKDWIPSGMDKYKFNPTAAAKLLAELGFTKKGSDGILVDKAGNKLEFTLITNAENNRRQSYAKVIQDEAKKVGVKINVSAIAFNQMTTLLDAKDNFGRRNFDAIIIGLTGGGQVYPVSGPSVVECKGLGDGGNLHMFNQSNKCRFPFETQAVNLFWKGRAEFDLAKRKAIAAQIQRNEMENQPYIQLAAQTVHFAWTDRVQGEYNRPQINSLNASTLFGPRDIALTWIKR", "function": "Probably part of a binding-protein-dependent transport system.", "AFDB_id": "AF-Q9RU24-F1-model_v4" }, { "swissprot_id": "Q9AE87", "sequence": "MKTQEIEKKVRQQDAQVLAQGYSPAIRAMEIAAIVSFVSLEVALVYRLWGTPYAGTWLLLSAVLLGYLAADFVSGFVHWMGDTWGSTEMPVLGKALIRPFREHHVDEKAITRHDFVETNGNNCLISLPVAIIALCLPMSGPGWVFCASFLGAMIFWVMATNQFHKWSHMDSPPALVGFLQRVHLILPPDHHRIHHTKPYNKYYCITVGWMNKPLTMVHFFPTAERLITWATGLLPRQDDIGAEAARALVVAAGGSEAPVVQAAKELLTQATVQEKPASTRP", "function": "Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the membrane, required for light-induced carotenogenesis. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms, most precisely in sensing photooxidative stress through singlet oxygen. Participates in the light-dependent inactivation of the antisigma factor CarR. Mediates signaling by singlet oxygen, generated via photoexcited protoporphyrin IX.", "AFDB_id": "AF-Q9AE87-F1-model_v4" }, { "swissprot_id": "I2DBY3", "sequence": "MRKSISTFILLSVLSVGQLVAARPRSTNAPPRRRTPQPRRTTSLFINPPALPDLPTVQAVDKLDDALDIDNIQSDILVGMKKTKELFFFFGVEDAATFKSKLASDILPLITTTTEILSTDTQPITAVNIAFSHTGLVALGVNDDIGDTDFVSGQFSEATTVGDRPTLWDPAFAGTKIHGVFLLASNTTEDINTELANIQSILGSSITEIHRLQGAARPGAEEGHEHFGFLDGISQPAVNGFTDTVLPGQTPVDPGLFLLGESGDPSQDSRPSWAVDGSFLVFRQLQQFVPEFNQFLADHPLDIPGRTAEEGSELLGARMVGRWKSGAPVFLSPTQDDPVLGADKNRNNDFNYLVASDPDPGTENHFNQTACPFGAHIRKVHPRGDLSPSAENPHFIIRSSIPYGPEVTDAEAASSTTSVDRGLAFVSYQSNIFNGFVFLQSIWINNVNFIFGKVDPTIGVDPIIGTLGGGPHNISGLNPLIPVNETVDFQDDPWNDVVIPRDFVVSHGGEYFFSPSLSGISAIAAA", "function": "Manganese-independent peroxidase that is able to convert a large number of compounds, but its physiological substrate is not known. In addition to classic peroxidase substrates (e.g. 2,6-dimethoxyphenol), oxidizes dyes such as Reactive Blue 5 and Reactive Black 5.", "AFDB_id": "AF-I2DBY3-F1-model_v4" }, { "swissprot_id": "A0A0G2K7V7", "sequence": "MEASSGTAGPAVLLLILALLLTESQGSRSQGTHTLRYDVTACFLEGSEQTRLLVLIYVDDELFLRYNGDRRSAKPWACWIKGHGGDETCTREAENLPKEEERLREMMADMINQKGHDKGPYTLQATLDCELQRNGSTRGFWHLGYEGRNLLTFDQKTLTWTMDVPFTQQKKTFEPRAPKADLVKTFLDETCPARLQRHLASLSNVLPDTGSPVVIVTCRNYPVGRITLTCRAFNLSSRVATLLWLRDGKPVQQDVFGPGTILPSGDGTYQTWVSIRVLPGQEPQFACNLRHSNRTIMQTAVSGESMGWPSASWATRQEAEGPHRTHNDHVVDGGLVTGNANKDSPDASSCATASAISAFPVVVLSVALPRAN", "function": "Binds to heparan sulfate proteoglycans on the surface of fibroblast cells.", "AFDB_id": "AF-A0A0G2K7V7-F1-model_v4" }, { "swissprot_id": "A0A0H3G4K1", "sequence": "MKLPPVFVFELVENQGLANIALIRPRVIAPDNNLRPGGIVSGIAGLLTLGQENRNLISENRQVINNNTTAIGQNSDRIDANAKGVADNRAAIGQNSGRIDANAKGVADNKAAIGRNSGRIDANAKGVADNKTAIGRNSGRIDTNAKGVADNRAAISQNRGRINANAAGVASNRAAIRQNSAAISALGQRVDGLQGQINSARKEARAGAANAAALSGLRYDNRPGKVSIATGVGGFKGSTALAAGIGYTSKNENARYNVSVAYNEAGTSWNAGASFTLN", "function": "Participates in bacterial attachment to several surfaces, including various extracellular matrix (ECM) components and a hydrophobic abiotic surface. Involved in adhesion to host epithelial cells and is required for full virulence in mice. Also implicated in the resistance to porcine serum.", "AFDB_id": "AF-A0A0H3G4K1-F1-model_v4" }, { "swissprot_id": "Q04HQ7", "sequence": "MANYELTYIVRPDLDKDAKAALVTRFDSILSDNGAKIDKSEDWDTRRFAYEINNYRQGTYHIVTFSSEDEKAVNEFDRLAKISGDILRHMIVAVDLEKLADAHAKQAAATQRAAERRAQREAERNAAQAQSSASNQARTAATTSGK", "function": "Binds together with S18 to 16S ribosomal RNA.", "AFDB_id": "AF-Q04HQ7-F1-model_v4" }, { "swissprot_id": "Q1IIG9", "sequence": "MADTFEFEIVTPDKLVVKDVAEQMQIPGKNGYLGILPGHAPLITELSIGEISYTLRGETKYLALAWGFAEVLPDKVTILAEAAERPEEIDVARAQEAKKRAEQRLQTSGPELDYQRALNAVKRAEVRLQVASHATSKAAVGH", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane.", "AFDB_id": "AF-Q1IIG9-F1-model_v4" }, { "swissprot_id": "Q9FGF6", "sequence": "MAIRVSHKSFLVALLLILFISSPTQARSLREVVRNRTLLVVEKSQESRKIRHEGGGSDVDGLMDMDYNSANKKRPIHNR", "function": "Signaling peptide (root growth factor) that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells. Also involved in the regulation of hypocotyl bending and root gravitropism, probably by influencing the formation of auxin gradients. Maintains the postembryonic root stem cell niche.", "AFDB_id": "AF-Q9FGF6-F1-model_v4" }, { "swissprot_id": "Q46604", "sequence": "MLPGTFFEVLKNEGVVAIATQGEDGPHLVNTWNSYLKVLDGNRIVVPVGGMHKTEANVARDERVLMTLGSRKVAGRNGPGTGFLIRGSAAFRTDGPEFEAIARFKWARAALVITVVSAEQTL", "function": "Functions as a redox protein with a potential of -325 mV.", "AFDB_id": "AF-Q46604-F1-model_v4" }, { "swissprot_id": "Q8NLB7", "sequence": "MTSHAPESGGLVTESTLGASNSSQTIENKGLTILGISGRRLAAVLIGWFFVIFDGYDLIVYGTVQSALAKEWNLSSATLGTIGSTAFFGMAIGAVFIGRLSDRVGRKAAVIGSVLILSVFTMLCAFAPNPWVFGAFRFIAGLGLGGLVPSVNAMTSDLVPRKTMSAWATVMMSGVPIGGSIAAVLALVVVPSSEEWGWRFMFLIALIPLVVGLPIAMKVIPSDKAIKADHDIREGHDEPAGFKDLLVDRYRWISIWFALATFVTLLAWYGLGTWLPRLMETAGYEFGHALMFTLALNLGAVIGSVVTAWAGDRFGPIRSGVIAAGIAGIALLLLLTYPPVTAVYVILILAGVGTHGTQILIIAAVANFYPSNLRGTALGWALGVGRIGAVVAPQLAGLLLAWNLGVNSNFIMFGTAALLSALALSVLLRLQKTYSVTHKVEIQG", "function": "Transport of gentisate (2,5-dihydroxybenzoate) into the cell. Does not transport 3-hydroxybenzoate or benzoate.", "AFDB_id": "AF-Q8NLB7-F1-model_v4" }, { "swissprot_id": "Q17QW0", "sequence": "MAKGLLMTYTLWAVGGPAGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWMLPSFVAQANRAQEQRQGSGRGTPPLSLIRFVAQMIVGMYFGLVALISLSFMASFYIVGLPLAVGLGVLLVAAVGNQTSDLKNTLGAAFLTSPIFYGRPIAILPISLAASITAQKHRRYKPSVGSETLSVRLYRLGLAYLAFTGPLVHSVLCHTAVTLSYVADTLGSFLSWFSFFPLLGRLLESVLLLPFRAWKLLVGDHGISSSYFQEWEKLYEFVHSFQDEKRQLALQVFGLSEGATNEEIHGRYRELVKTWHPDHNRYQMEEAQRRFLEIQAAYEVLRQPRKPRGSWRWEETSF", "function": "May function as a co-chaperone.", "AFDB_id": "AF-Q17QW0-F1-model_v4" }, { "swissprot_id": "Q9SQT9", "sequence": "MASSILLTLITFIFLSSLSLSSPTTNTIPSSQTISPSEEKISPEIAPLLPSPAVSSTQTIPSSSTLPEPENDDVSADPDPAFAPSASPPASSLASLSSQAPGVFIYFVFAAVYCFSLRLLAVSAI", "function": "Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.", "AFDB_id": "AF-Q9SQT9-F1-model_v4" }, { "swissprot_id": "Q9LA53", "sequence": "MSKKFTMTLLSSSLAGLLVMSGGVSAQEEKYTVPYAIGEGKWGNTYEVVKTGGNGNFRYEVKEKNGKKRSLFTFDSKGDVIINGSGITYTIHDGALNDFAQTAEKKKNGQSQSHRMTDSVVRDVYNKVYSLQRTKITGFSVEDGENGKVSLGSDAKASGEFSVAVGNGAKATEKASTSVGSWSAALGRQSVALGVGTYAYANASTAAGTAAYVDGSAIYGTAIGNYAKVDKNATEGVALGAKAISAHKNSVALGANSRTTRDNEVYIGYEEASGKAYKTRTLGGLTDGTRPSDAATVRQVDRVKDSVEQLAQDTNTRLVVEAKKSREYTDSRTTVGVNPDGKLTRAEGATKTIAVNDGLVALSGRTDRIDYAVGSVDRRVTKNTQAIQSNTRQLQEHNARLNSQQRQIRENHEEMKRAAAQSAALAGLFQPYSVGKFNATAALGGYSDKQAVAVGVGYRFNEQTAAKAGIAASDGDVSYNMGVNFEF", "function": "Binds (in a non-immune fashion) to the Fc portion of human IgG and very weakly to IgA; binding occurs on the cell surface. Confers the ability to survive exposure to human serum exposure.", "AFDB_id": "AF-Q9LA53-F1-model_v4" }, { "swissprot_id": "P9WJ92", "sequence": "MTEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPYTDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLLYANRDDRSVIFGDALRELAAKYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQQVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRAGKVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE", "function": "Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.", "AFDB_id": "AF-P9WJ92-F1-model_v4" }, { "swissprot_id": "Q47418", "sequence": "MAQIGIFVGTVYGNALLVAEEAENILKDRGHEVKVFEDATLESWLDYREQTVLVVTSTTGQGQLPDSIVPLYAALREKGGYQPALRYGVIALGDSSYPNFCAGGHLFDALLQEIGAKRLGDVLDVDAVEHPEPEVISCPWVEAWADLVDAQ", "function": "Probable electron transporter.", "AFDB_id": "AF-Q47418-F1-model_v4" }, { "swissprot_id": "P96710", "sequence": "MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVISGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAISAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTILGISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAGKTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALFNQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLMSIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNHLRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPETKNKSLEEIEKLWIK", "function": "Uptake of L-arabinose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system). In the presence of inducing amounts of L-arabinose, can import both D-galactose and D-xylose. Can also transport the disaccharide alpha-1,5-arabinobiose.", "AFDB_id": "AF-P96710-F1-model_v4" }, { "swissprot_id": "T2KMG4", "sequence": "MKTRYFLLLGICMLSCRTDEKKQVQKEVDKPNVLFIAVDDLNNMISPIANFSNIQTPNFDRLAAMGVTFTDAHCPAPLCGPSRSAIMTGLRPSTTGIYGMTPDNKIRRDDNEATKDIIFLPEYFKKNGYHSMGIGKLFHNYAPDGMFDEGGGRVKGFGPFPEKRFVWDGFGTSKSRKGQYGRTNTDWGAFPESDTLMPDHQAVNWVLERFNKNYKQPFFLALGFQRPHVPLYVPQKWFDLYPLESIQTPPYQSDDLNDIPPVGLKINDLPMMPSTEWAINSGEWKKIIQAYLACVSFVDYELGRVLDALKNSPYAKNTIIVLWSDHGYRLGEKGTFAKHALWESATKAPLFFAGPNLPKGKKIDAPVEMLSIYPTLLELSGLQAYARNEAKSLVRMMQKNEGLKDTYAITTYGKNNHAVKVDGYRYIQYEDGTEEFYDNASDPNEWINEANNFKFKSKIEALKALLPKTNATWDAESNYTFQPYFVEQKTRGNVNAAKAVKVIGAER", "function": "Sulfatase that may be involved in ulvan degradation. Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall. It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl) (Probable). Has no activity on different ulvan polymers.", "AFDB_id": "AF-T2KMG4-F1-model_v4" }, { "swissprot_id": "Q54MC0", "sequence": "MDDQYKNDHQNFVSGNDGSTFFETCFILTLMPISVLFQRVVFATFFNNDKFPLPLALRFILEFFFIIVPFISAITFTELTPFLIVGMLITCLVVPMFAQKNVTIYFKNPKETLLNLNSMRKGFLEEYRAFVMAATCICILAVDFQVFPRRLGKTETYGISLMDIGVGSVVLSGALVSRQSRSSLIEKQQKKKREEEEDDNDKINKTSSSSSSSSSALKQQQQQVLSRSSLMWHQVKAQAPLMILGFVRMILTKSINYQEHVSEYGLHWNFFFTLGFVSISLAFLKFNANISAILGVVLICVYQFLLNSFGLTDYILNHPRDNLISMNKEGICSFVGYLAIYLIGTKIGTELFKVRSSLTEWRKFATKLLISSIVFYILWILCEIYIDKTSRRMANLGYVLAILSINLFNFSINILITLITGNHNASVIAKSINRNQLFIFLLGNILTGLINFSMKTIYAPVEQSMIIITSYTFALCLLAFILDYKNINIKFW", "function": "Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.", "AFDB_id": "AF-Q54MC0-F1-model_v4" }, { "swissprot_id": "Q9LSP7", "sequence": "MADERYNRKNPAVKRILQEVKEMQANPSDDFMSLPLEENIFEWQFAIRGPGDTEFEGGIYHGRIQLPADYPFKPPSFMLLTPNGRFETNTKICLSISNYHPEHWQPSWSVRTALVALIAFMPTSPNGALGSVDYPKDERRTLAIKSRETPPKYGSPERQKIIDEIHQYILSKATVVPKPLPLECSQAPSIVSEAHSQVEPQEAITVVEERSIATTDTIVDDQIIEETAEAVNTAASVVPAAAPLPAVEVVVKASVSGEQRMARRAAQKPVDDRLFTWAAVGLTIAIMVLLLKKFIKSNGYSTGFMDDQS", "function": "Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.", "AFDB_id": "AF-Q9LSP7-F1-model_v4" }, { "swissprot_id": "O14223", "sequence": "MDKTKMFSAINLGVGGIFVLSGFIKLFSFSFVNALLALFIIVFGLGTIGLEKEIPPIAIKYGSFMFSFLGRGFFYAFMGTLLFSYSGFTSFLGFLVLLAGIAYCGANYVAGLQDYAPRSMRDNDWDDNVDEV", "function": "Golgi membrane protein involved in vesicular trafficking.", "AFDB_id": "AF-O14223-F1-model_v4" }, { "swissprot_id": "Q6J9G1", "sequence": "MGEKGHLSRVLLECSLSDKLCVVREKQYEVIIVPALLVGGFLILLAIILWLFIRGQRSQRQSPGPRGTASVPASRGRSQEAAGHGEKVLLPLKETSVEGFLRAATPRLAKLQVPREQLLEVLEQIHSGSCGTLYHATMTTKDHPKPKSVVLKALEDPVGLQEVQDFIGRIQFYQYLGKHKNLVQLEGCCTERLPLYMMLEDVVPGDLLSFLWTCRRDVMTMDGLLYDLTEKQIYHIGKQILLALEFLQEKHLFHGDVAARNILIQSDLTPKLCHLGLAYEVHAHGAISSARSSTIPLKWLAPERLLLRPASIRGDIWSFGILLYEMVTLGAPPYPEVPPTSILQYLQRKKIMKRPSSCSHAMYNIMKCCWRWSEDSRPLLGQLLQRLEAASRSADDKAVLQVPELVVPELYADVAGIRAESISYSFSVL", "function": "Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways.", "AFDB_id": "AF-Q6J9G1-F1-model_v4" }, { "swissprot_id": "P42674", "sequence": "MKLILFLSGLVSLVLCTLAAPTGDQKEIHTETPPPKKPSETTTPGALKTPQPEPKDEEPTPGAFQGDMMLTEDQQRESKEAIDDEMTGRKKRKATIYESQRWPYKVIPYVISPSSSGQSSLIRNAMDHWEQNTCLRFEPRTSSHSRQLGHNAYLSFFRGSGCWSYVGKAFNGEQQISIGNGCAYFGTIVHEIGHAIGFHHEQSRPDRDDYINVLYQNIQSGRQHNFAKYTWGRVTSRNVEYDVGSIMHYGGYGFSSNGRPTITTRDPRLNSRLGQRIALSPADIELANLIYECDDIEDCAGANECLNGGYHDTECNCVCPSGYNGDLCEDAVTTTRPDCSERFTEMTGVITSPNWPGRYEDNMACVYQIEGPPGSTIELTFTEMNIENHAACRYDAVEVRKDDINSDGEKFCGNTLPAVQISSGNQMLISFTSDPSITGRGFRATYRIVILTTTQIPDTTTISTTTPVPTTTQATTDETVVGSCGGSFGGTQGRVATPNYPNNYDNDLECVYVIEVEIGRRVELDFIDFVLEDETNCRWDSLSINLGDGIKIDMKMCGREYPAASLVSIGNNMELTLISDRSVTDRGFMADYRAIDL", "function": "Could be involved in the differentiation of ectodermal lineages and subsequent patterning of the embryo.", "AFDB_id": "AF-P42674-F1-model_v4" }, { "swissprot_id": "Q6ZJ48", "sequence": "MAGVLRLAGAARSPLARALAPAARRMGASAAAAMEDEAYWTEWEEEEEKARARESAPVAEMCPTGGGGGGPQWVVMGRPGPQKHAHAARLAEVLAVPYISMGTLVRQELSPASSLYKKIANSVNEGKLVPEDIIFGLLTKRLEEGYNKGETGFILDGIPRTHMQAEILDEIVDIDLVLNFKCADNCFMKRRFGGDICPHCGQLFDFSKTASSDRNPSLGSCTWPSQVQHAAVLGLEDSRMEKMRAYAEQTKLLEDYYRKQRKLMELKTSARPGETWQGLVAALHLQHLDASPTPHKLTM", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.", "AFDB_id": "AF-Q6ZJ48-F1-model_v4" }, { "swissprot_id": "A0A0E4AZF8", "sequence": "MADQAQDVRPTEWGPGKTPQGRARLPSSRPREKPQLSCNLCRRRKLRCDRQRPCSSCAQRELGLSCTYASDRVLSNGVAHQTRTTTQDRIRHLESLVYDLMQNSSANVNAQDQVGATPSPRGQPRGPDYPTPAAVHAPSTNEEPVSAAVSPADYGSMQSTGGGANYVGSAHWAAVLDGIAELKDHLDNEESHHSDSQGVDPPCPQVTGPQLLYGCPKPADKDEILSSIPARSVVDRLVSRYFNSFEMSPAVLHSVQFLKEYEAFWEDPQTTSPIWLGLLFTIMCLATQFEKSRLDPGVQSPAVLSMERELQEMVDTFRLRIPQCLVLGSYAKGGPFVLETLMLYIAAEIFLSSDAEIEIWILMGNTVQLALHMGYHRDPKHFKGLSPFAAEMRRRIWATIVEMDLGLSAQMGLPRMVKHWQTDTQEPSNLQDSDFDSATVEMPPSRLNTDLTPILYRLVKARLMTTIGYIWDFSADVRPYPYTEVQKMDDKLDLARKSIPECLKWHSMARNITDSPQHIMQKVILETVFYRAKIVLHRKYMFLPLAQSASSRRIVLESALKLLDYQHMLQEETQPFCQLYQERWRVSSLVNHDFLLATSILCYYLQHAWGATQRVSESDSFDETIMASLRRSHDIWLQSSNSSKEARKVVRALAVVLGRVNTPSADSVGEAGLVFGLPSTYPPSTTNDYSQETPGGLGSQFPMFNSALMPNWATFADDLISAPMITPTAEWQEMDETVDAMGSLNWPWNLQ", "function": "Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of fusarisetin A.", "AFDB_id": "AF-A0A0E4AZF8-F1-model_v4" }, { "swissprot_id": "Q2UPB6", "sequence": "MSRSTMLAHSAIPSSLIRMDLLSPWILTATAPKFLRLFAPATRRRSARSTIPSWSRSSSGKQAHHAWLSSITPCDGARSPWLARIPMAASSLQAQSPLGARRRVYQHLPEEADRLLKGRAQIVNVWRPLRGPVQDWPLAVMDCSTLAQAHIHPTKLYRNRFELRGETVSISHDESQRWYYLDGQQTDECTLIKIWDSKEGISGHMCAHCAFQHPNTPVDAPLRESVEVRCLVFYENQE", "function": "Part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells. The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues. One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine. After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT. In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine. Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway.", "AFDB_id": "AF-Q2UPB6-F1-model_v4" }, { "swissprot_id": "Q8TR92", "sequence": "MARDRRDYYYHQAKEEGYRSRASFKLKQINEKHNVIKRGDSVVDLGAAPGGWLQVAKQLSGGKVLGVDLQRIAPIEGVETIQGDINADSTIKKIIRAVGEKGADVVLCDAAPNLSGNWSYDHARSIELTTSALECAKKILKPKGNFVVKVFQGDMFNDYLEKVRDNFVHVKAYSPQASRSQSAEIYVIGKKFLTAPLRRGDKFVVDIEKLGSGGDGAVLIEGFVVFVKEVEVGEKVRIKIADVKPNFAFADVEERLEKAEDSENLGNSEKAE", "function": "Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.", "AFDB_id": "AF-Q8TR92-F1-model_v4" }, { "swissprot_id": "O87688", "sequence": "MSVTTWNLNGTKHHVLICNGSSCMRKGGEEATQAIRNKVAELNLDEAVHTTRTCNGRCKDAPVAIVYPSGDWYKQVTEKVAHRIVEEHLAGGCSLKESLIYEYDQKGFVSPENSDSIEGIDKVKSNA", "function": "Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.", "AFDB_id": "AF-O87688-F1-model_v4" }, { "swissprot_id": "P35641", "sequence": "MKKILNLFVISAFLSISSAAFAQNVKPAATKPSVATLPNGASSLTETYGLWSVNCGIQDGNKICIMLRQEVNEQDRVLLSMSVSLDGEGTVSGNLTIPFGILVSKPIRLHVDDSKSVIESNVRTCVPAGCVVPIVFDKNFVGSLRAGKQLKLSMTVAAPGEPTLDNLFVQLDGFSNALKRLTSLQK", "function": "Required with NudH/IalA for erythrocytes invasion.", "AFDB_id": "AF-P35641-F1-model_v4" }, { "swissprot_id": "Q5R573", "sequence": "MAEHRTKPSELDQGKCDADDNVKIICLGDSAVGKSKLMERFLMDGFQPQQLSTYALTLYKHTATVDGKTILVDFWDTAGQERFQSMHASYYHKAHACIMVFDVQRKVTYKNLSAWYTELREFRPEIPCLVVANKIDADINVTQKSFNFAKKFSLPLYFVSAADGTNVVKLFNDAIRLAVSYKQNSQDFMDEILQELENFNLEQEEEDVPDQEQSGSIETPSEEVASPHS", "function": "Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.", "AFDB_id": "AF-Q5R573-F1-model_v4" }, { "swissprot_id": "Q57W26", "sequence": "MSTATSAPVVESMSDTVVCPQLSRHSTSLEELYTIGYNRSHSPSCFSSAGCEEEEGQKNVLAERYKTKLCKNFVQYGTCPYDIRCMFAHGEEELRTAEMNIMDGLVTKDAITSFQKLWHRAVSASSGSKHHSSHVANRRGVMTTATTTTTAGGSTDAAMHICRRMQRVVAAAAAAVPCGGRRVVSGSIRIRGCVRHNPYCHNILPTVSRYYSTMPDVFTRPYSKSDSCGNEAITEGNAWTYANEEGNEKETPAMISSGVPELTAWKRFNYVAERSQCTSVPEQNLPCADFAAIKESNNTGGNASGVDVENVDDAEHSTCSSVGNESGYFCRASRSASCGEQSQSHLKREGNEGRGEGLHMFLSL", "function": "RNA-binding protein involved in regulation of mRNA stability. Binds AU-rich regions in the 3'-UTR of mRNAs and promotes their stabilization by recruiting a MKT1-containing complex. Stabilizes chaperone mRNAs during stress that causes an accumulation of misfolded or unfolded proteins in the cytoplasm.", "AFDB_id": "AF-Q57W26-F1-model_v4" }, { "swissprot_id": "Q6PSU2", "sequence": "MAKLTILVALALFLLAAHASARQQWELQGDRRCQSQLERANLRPCEQHLMQKIQRDEDSYGRDPYSPSQDPYSPSQDPDRRDPYSPSPYDRRGAGSSQHQERCCNELNEFENNQRCMCEALQQIMENQSDRLQGRQQEQQFKRELRNLPQQCGLRAPQRCDLEVESGGRDRY", "function": "Weak inhibitor of trypsin.", "AFDB_id": "AF-Q6PSU2-F1-model_v4" }, { "swissprot_id": "Q40062", "sequence": "MENILHATPAHVSLPESFVFASDKVPPATKAVVSLPIIDLSCGRDEVRRSILEAGKELGFFQVVNHGVSKQVMRDMEGMCEQFFHLPAADKASLYSEERHKPNRLFSGATYDTGGEKYWRDCLRLACPFPVDDSINEWPDTPKGLRDVIEKFTSQTRDVGKELLRLLCEGMGIQADYFEGDLSGGNVILNINHYPSCPNPDKALGQPPHCDRNLITLLLPGAVNGLEVSYKGDWIKVDPAPNAFVVNFGQQLEVVTNGLLKSIEHRAMTNSALARTSVATFIMPTQECLIGPAKEFLSKENPPCYRTTMFRDFMRIYNVVKLGSSLNLTTNLKNVQKEI", "function": "Involved in the biosynthesis of mugineic acid family of phytosiderophores. Hydroxylates the C-2' positions of 2'-deoxymugineic acid (DMA) and 3-epihydroxymugineic acid (epiHDMA). May be involved in boron tolerance.", "AFDB_id": "AF-Q40062-F1-model_v4" }, { "swissprot_id": "P0CO56", "sequence": "MTQCGDRRLLALIIYHGAIQTPPPTDPNAAPAHRPAPRPALGRCRPPHRRRRRLRPPVRPPVSLPVALTTRSSAAQLGYLQDPFASLLYRPPMPQPGAFAPQAVGRARKPPLINVGTHHRTWGIDRLVDRFLQRGGKQVVSLGAGSDTRFWRLMSRATPPDLARYVEIDFPHLTSPKAQRIARHRKLYQYLGPSSTAMPPPGHPYTVSKGGTQLSSPLYTLLPLDLRPSPSEPASSISAILSHHVLPQLDPRLPTLFLAECLFPYMSPEDSREIIKWFGETFCSCMGVVYEMVGLDDSFGNVMKRNLAVRNLSIPGSIFSTPESQAGRFTSPMLQGGKFDSAGAKTLWQIREEDVGPEELQRISKLEILDEIEELRLVLEHYVIAWGTKGECMSSISL", "function": "Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.", "AFDB_id": "AF-P0CO56-F1-model_v4" }, { "swissprot_id": "P9WJA0", "sequence": "MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQRAQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRPVDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPGDTMV", "function": "Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol.", "AFDB_id": "AF-P9WJA0-F1-model_v4" }, { "swissprot_id": "Q95V11", "sequence": "MEQEREIVFSLSPEETSELKNGVNLISRSEKEKFVIYKDPTAENTVEEPATSHMYKACLNKCKHQGGTFIKDIEDGDNCILRCTKHGWKLDAKTMRYVNPPDSFSQQQLVPEYNEDGSLDIVELKPPQPWETDKRDPMPLEVGEVQITYFTHACIEIKLGDLIMFTDPWLIGPAFARGWWLMHEPPADWLDRLAKADLIYISHLHSDHLNYPTLELLSQRNPDIPIYVGDTSMPVFVRLEQSGVKLNNIHIKKFGKWIEINKDTRFMIMMDGVHPDMDTCALIDYKGHLILDTVDCTNPNGGRLPIGVDMMLSDFAGGASGFPMTFSGGKYTEEWKAEFVKRERRKLLYYKMQQVRDVAPTVYCPFAGYFVEAHPSDHYIRSTNTKNDPDALNALINKYSPNIKTWSPSPGAVLDLKKAIQGDRDFITDPPRGTQKFKDSWDFEKYVNAINKNIEEEIFSYPEWIQFYYKWTGFKNYNLVIRMVERDDDFCPVVGGYDFMVDFVGEEPTFPTERPAREHSYLEMENRIGVHRETVRQGLFWDDLYIGFNNRISREPDTFHYLFWNHMQILLPRTDPDWEGFLRDMKTEGAPQKAIWNPSQATPAVEAKDPSSDSKDSATKPGTHWNYERLLRPLGIVVALVGVGVAIWKSESK", "function": "Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.", "AFDB_id": "AF-Q95V11-F1-model_v4" }, { "swissprot_id": "P22697", "sequence": "MSSADFNFGDFTTTYTSPTIPAYPDTLGQLQPIQPNPQAAYPPVSQHHASHHVQHPHQPGYVLSNPPQLSGNKRKASDAMSVPPTPGARVMSFEEASRLAAEEDKRKRNTAASARFRIKKKQREQALEKSAKEMSEKVTQLEGRIQALETENKWLKGLVTEKHGSKEDILKLLREFSAHAAKVSKDAAAAAADKAEAAADKADAERAREESSFCVSTSSPSSDESVDTDNKKRRKD", "function": "Turns on the expression of structural genes which encode sulfur-catabolic enzymes. Binds to sequence elements upstream of these genes.", "AFDB_id": "AF-P22697-F1-model_v4" }, { "swissprot_id": "Q1IS57", "sequence": "MSIAPLLRKVFLIDLIKGLSITFKYQAPKDCQTEQYPQERPVITDRFRGQPMMKLGENGETLCIGCNLCALACPENLIAMKSDRDPVTKKKVMVTYVYDVSRCMFCGLCEEACPTQSLKLGTGYEMALYSREGMVLDRKVLEHRTAPEPYEK", "function": "NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-Q1IS57-F1-model_v4" }, { "swissprot_id": "P62506", "sequence": "MIFGYINKLSILNVNPFSKASQSAKLLLAVASKETSNSLYGLNLITSLASKDTNSKPSVEVVYKDGKKLTVDPTKMNIGRLTELIDDYSKTLKFKEMMQK", "function": "Involved in mitochondrial genome encoded proteins translation.", "AFDB_id": "AF-P62506-F1-model_v4" }, { "swissprot_id": "Q9Z258", "sequence": "MARAKLPRSPSEGKAGPGDTPAGSAAPEEPHGLSPLLPTRGGGSVGSDVGQRLHVEDFSLDSSLSQVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDNPDQGIGCWGCTKYNYTFNGSSSEFHWAPILWVERKMALWVIQVIVATISFLETMLLIYLSYKGNIWEQIFHVSFVLEMINTLPFIITVFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGGNLNLLTSFYFCIVTFSTVGFGDVTPKIWPSQLLVVILICVTLVVLPLQFEELVYLWMERQKSGGNYSRHRARTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPSEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREENKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKQNRRGLAGQALYEGPSRLPVHSIIASMVAMDLQNTDCRPSQGGSGGGGGKLTLPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRRELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKQERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKVTEDDLWIRTYGRLFQKLCSSSAEIPIGIYRTECHVFSSEPHDLRAQSQISVNMEDCEDTREAKGPWGTRAASGGGSTHGRHGGSADPVEHPLLRRKSLQWARKLSRKSSKQAGKAPMTTDWITQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHHQNTLSYVLINPPPDTRLEPNDIVYLIRSDPLAHVTSSSQSRKSSCSNKLSSCNPETRDETQL", "function": "Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).", "AFDB_id": "AF-Q9Z258-F1-model_v4" }, { "swissprot_id": "B0JRV5", "sequence": "MTPELITFGRYLAGEFENQRQAQAEPVWYVHLRLWLRPLPLFREDSIALFAEQASIINLDQPYRPRLWRLTHSESGGLEVRHYMFNDLKSVQGAGKNPDILRKISLEDLTFLPTCTLAVKVNTLADNQYQFIAQPQPEQRCQFTYEGTTYQVALGFEVTSHSLKTYDKGLDPGTGKGIWGALLGPYQYEKKRDFSAELDV", "function": "Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.", "AFDB_id": "AF-B0JRV5-F1-model_v4" }, { "swissprot_id": "A9A623", "sequence": "MKSAILITYDKEDVINEAKGLCDAAGFQVVHTIKQKFLKRPKYGISGGILERLEEISEKIRPDVIVFDEVLKPSQNYNLAAALHREILDREALILEIFESRASSAESKLQVKLAQLRYEMARAKEKVRLSSMGEQPGFMGIGKFEVDVYYNDIKHRMNTVRSKLEKAGKQRELHRQGRKRMGFKTISLAGYTSAGKTTLFNMMTGETRDQSSELFTTLSTTTRRVSINQEPFLISDTVGFISKLPAYMIDAFKSTLEELGHTDIIIVVIDIGDSIFELKKKFSSCMRTLSELGVEKDRMVYALNKSDLLEHSEIEEKIETLNLVDNKKWIPVSAKTGKNVKQLKELIGDILESHNSHKFGKKIGVEETFGN", "function": "GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.", "AFDB_id": "AF-A9A623-F1-model_v4" }, { "swissprot_id": "P38262", "sequence": "MSITSEELNYLIWRYCQEMGHEVSALALQDETRVLEFDEKYKEHIPLGTLVNLVQRGILYTESELMVDSKGDISALNEHHLSEDFNLVQALQIDKEKFPEISSEGRFTLETNSESNKAGEDGASTVERETQEDDTNSIDSSDDLDGFVKILKEIVKLDNIVSSTWNPLDESILAYGEKNSVARLARIVETDQEGKKYWKLTIIAELRHPFALSASSGKTTNQVTCLAWSHDGNSIVTGVENGELRLWNKTGALLNVLNFHRAPIVSVKWNKDGTHIISMDVENVTILWNVISGTVMQHFELKETGGSSINAENHSGDGSLGVDVEWVDDDKFVIPGPKGAIFVYQITEKTPTGKLIGHHGPISVLEFNDTNKLLLSASDDGTLRIWHGGNGNSQNCFYGHSQSIVSASWVGDDKVISCSMDGSVRLWSLKQNTLLALSIVDGVPIFAGRISQDGQKYAVAFMDGQVNVYDLKKLNSKSRSLYGNRDGILNPLPIPLYASYQSSQDNDYIFDLSWNCAGNKISVAYSLQEGSVVAI", "function": "Antagonizes telomeric silencing in yeast. May recruit SIR4 to non-telomeric sites or repression.", "AFDB_id": "AF-P38262-F1-model_v4" }, { "swissprot_id": "B1M6B8", "sequence": "MDRPTTYPMDQPAGFRDAQGRHGGVVLPARPEPIALDPATTFLIVVDVQNAYASPGGYLDRAGFDVSGTGPVIARIARAVAAARAAGIPVLWFQNGWDPAYVEAGGPGSPNWHKSNALKTMRRNPEANTQLLAKGSWDYALVDALTPEPGDIVMGKPRYSGFYNTPLDSTLRARGVTTLVFTGIATNVCVESTLRDGFHREYFGIVLADATHQAGPESLHRAALANIETFFGWVSDVAAFESALGVPSRAPAGADLAG", "function": "Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate. The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.", "AFDB_id": "AF-B1M6B8-F1-model_v4" }, { "swissprot_id": "P40214", "sequence": "MEENKLSGNKPIQLATWSNQMGSPENNGNNANNGSDVQNVIQKALGLIRQLNNNGLMSPMEEEHSQPSSSQETLSVDREINEQGRLRLLMQAKDDNTRKEVGTYSSPMDSAYARENMLNVLQSLVTHLNQAVSQIQQLKFKNMILTSNENNIQSRHEVEDNLQKQQFERMKCQFLLERQSLKDQLRKRENKIVKYKQKIIEKNKKLNNLAKVLNQHAISDTSQIDSFSSSVKKTPSSTTTPQEMKSDMLNTLGILATHVLKDEIDDDSGNQTILQLAAGSISNDCNTTELEITCSPEMGRTITHNRPNTKDESIQDSHGNRTLQLPKMKSFSTIDGSIKDIK", "function": "In concert with FKH1, plays a role in directionality of mating type switching by controlling which donor mating-type locus is inserted into MAT locus during mating type switching.", "AFDB_id": "AF-P40214-F1-model_v4" }, { "swissprot_id": "O13335", "sequence": "MAADVPGSPLAKNATTEEALAWYKSQYEELEQELKEFQQSSKELEAELEKDLDAADKRERALQQKAEGLSYEVEEWKRKYKESKSEANAAQSALEKEITALRETNRTLQLKLRDIEVANDDFERQARNTSSSLEDLESKYNVAIERAVMMEEEIKIGEQERERLRVEAQRLREELSDLKIEAEILQSKLRKHQARGHLTQITTTIAPAPASPLSTASSPLVSTPPDTKSLSTIDTLSEVQDPPSPPMSDASLGKGLRASRSTPVKQTASRPGGCRTPKTSISKSAAAKSSAQATHKANQSFSENNITPKPKPLSSSTSSQSNRPSNGRFNTNSYPMVRTPSSRPSGARAAERPRAPVHRIPPSNSLTHIRTLTAQMQKLEARVHSARSKLPATAQTPPKQSPRFSGGIGGLAATVAMRGKKQRGVGASTSSLNLLDDDNASDISGTHSNPDFRSSTLNLSKHIPRLSTSGVSRIAFGPLPIRHPASAAASTTSTSTATATNVDSEVSRPSSRASSSGYGRPISRADSHSTAASGYMPSSSSRPISRTSLPGHGTRTPVGSWPRSSGNLSAYGHGPAHSQASISYSTAEEDELTDDGQRELRSKTTPARRRTGTLSARDAPDHHHTGIPIPGSGGNRRQSGSSSASRSSVTGSLSLRRQSNAAALGHGHGHNAGYGHGHGTVPGGTTVRKVVDLGETY", "function": "Required for nuclear migration within hyphae during vegetative growth.", "AFDB_id": "AF-O13335-F1-model_v4" }, { "swissprot_id": "Q8EUW9", "sequence": "MNLKDLIKLLEVKFPQIDSNEVESKITIYKNYLQQENKIHNLTRLDKEEEIYQKYFYESILNFHNDLFDNKNINLLDIGSGSGVPGIFLKILFPHINLYIVESNTKKVNFLNNLVDKLELENVFISNQRCEDYIKDKIEFFDLITCRAVAELRILLELSFPGLKINGIGFFLKSNNYLVELDNAKNISSKLKIEEEPKIETIEYDGKTFVSLKYIKKNKVNNIFPRTWKEILNNDKN", "function": "Specifically methylates the N7 position of a guanine in 16S rRNA.", "AFDB_id": "AF-Q8EUW9-F1-model_v4" }, { "swissprot_id": "Q9YC00", "sequence": "MGLIDISVKPQTEQCSEVLRTAGRLGYTAVAIPPESADECMSLEGDGIPRLYRRGYVEASTRRDVRRAAEKLAGVVDFIVVKPLTLEAARYAAANKRVHIIRVDGSNLWAADRGTAEIMAQRGWGALEVSLRNLTLNPGSPAAWRALAVVLRRSFAYGVHVFLASDAEEPHELWSPYSGASLAALLGVPWSHAMLYNSEERLRILLDASRA", "function": "Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.", "AFDB_id": "AF-Q9YC00-F1-model_v4" }, { "swissprot_id": "P36263", "sequence": "MVDSKKNKKQQVTDFSNLLSQSKGFVIFDYSGMSAVDATLMRKKLFNKGSKIKIVKNNILRRALKTSNFEGVDESVIKGKIAVAVGINEILETLKVVDSVVKEKELMKFVCGHFDNRIFNSDDLQKIAKLPGRNELYGMFLSVLQAPLRKFLYALQAVRNAK", "function": "Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.", "AFDB_id": "AF-P36263-F1-model_v4" }, { "swissprot_id": "O95843", "sequence": "MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLRVICNGKQPDMETDSSKSPDKAGLGKVKMK", "function": "Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.", "AFDB_id": "AF-O95843-F1-model_v4" }, { "swissprot_id": "Q2PE14", "sequence": "MDNSVILIDDSQNSVVIVDDDVEDGELEDDVVFVCPEELTRKEIEPPTDKIEEKHSNTSIQDTTEEDGDSLVFEVRFNKEAHFTSLQQQVLVALEGAFADKQIVFRDNPQELMISAFERSRTLPEEEPQDLFLIDTQPAAKLNAANVPSYKRCNADILDEQTEERKKLKAEAVNKCFRPKAQSSCFNCGDTEHSLRDCTKPRNNSRITRARKKMTSRTERYHVDTEQRFGHIRPGKISTKTRHAMGYSRGQLPFIFYRMRVLGYPPAWLEEAKVQSSGIALFNADGSEVTKSDEEEGESETFKYDVNKIVEYPGFNVQPKANCFDDFKHHNVPPFQESQSKENFIKSLGENVINGYKRKKLVDLPAPHDRVPAPSELLTSFDDYDMELEEETEDPPLPPSVPPPQPPPPEECEDGELTARSPSPSLEDLKAQQEELLQELDVNASHNTTANESKSPTDLDDTSETEVGPSAAESGNNEQSRSAPSTPFKASYEGTPLLKFSVYDRLPVGSNFKVGVSDVINFENLPDSTGKYEQMKDLLKNVREKMVKLQNEN", "function": "Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. May be involved in pre-mRNA splicing.", "AFDB_id": "AF-Q2PE14-F1-model_v4" }, { "swissprot_id": "P96169", "sequence": "MSNIEHGLSFIDIMVFAIYVAIIIGVGLWVSRDKKGTQKSTEDYFLAGKSLPWWAVGASLIAANISAEQFIGMSGSGYSIGLAIASYEWMSAITLIIVGKYFLPIFIEKGIYTIPEFVEKRFNKKLKTILAVFWISLYIFVNLTSVLYLGGLALETILGIPLMYSILGLALFALVYSIYGGLSAVVWTDVIQVFFLVLGGFMTTYMAVSFIGGTDGWFAGVSKMVDAAPGHFEMILDQSNPQYMNLPGIAVLIGGLWVANLYYWGFNQYIIQRTLAAKSVSEAQKGIVFAAFLKLIVPFLVVLPGIAAYVITSDPQLMASLGDIAATNLPSAANADKAYPWLTQFLPVGVKGVVFAALAAAIVSSLASMLNSTATIFTMDIYKEYISPDSGDHKLVNVGRTAAVVALIIACLIAPMLGGIGQAFQYIQEYTGLVSPGILAVFLLGLFWKKTTSKGAIIGVVASIPFALFLKFMPLSMPFMDQMLYTLLFTMVVIAFTSLSTSINDDDPKGISVTSSMFVTDRSFNIAAYGIMIVLAVLYTLFW", "function": "Actively transports glucose into cells by Na(+) cotransport.", "AFDB_id": "AF-P96169-F1-model_v4" }, { "swissprot_id": "Q53TQ3", "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKVRHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPLHYLETELEDPFAFNEEDDDLKKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPPPAPSQQQPPQQHSHLSPLSTSLKPPAPPQGSVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPTVDPPRTDRILMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEEPEDSEQASPYQVAWSIRETLRYQRHASDDDDAESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTFRKALLQAASKEPECTGQLIQELRRAACSRTSISRTKLREVEPAACSGTVKGEQCANKALPFTRHCFQHILLNHSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDNSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPASVSLPVEASHIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLAQSDGVPVQELSDRGIGVFSTGTGASGIQSLSREVNTDLGELLNGRIVHDNFSSLELDENLLRSATLSNPPTPLAGQIQGQFSAPANVGLTSATLISQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNMAATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLGADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPFPSPN", "function": "Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.", "AFDB_id": "AF-Q53TQ3-F1-model_v4" }, { "swissprot_id": "P38915", "sequence": "MDEVDDILINNQVVDDEEDDEEMLSGLENDSKQDLEGNDDGGEDEEDDDDDDEDDDDDEDEREDDDEQEDDDGEDDAARMDKTATPTNEHQHDEQKAAAAGAGGAGDSGDAVTKIGSEDVKLSDVDGGVGSREASSSTHEASANGEVYEYYKHMLNAAQIADSYNIYPTAAIPIQTHVNALAVSRGLKYLFLGGSDGYIRKYDLLNTLEGKLSLTILQKHSLAESIQNAGILQSYWENEIPQKKSEMKLSANKTDYEPKVSPVHSLEVQSECLFILSGLQNGGITMQGVRYMEGSIAHYFKGRNGHTQIVNILRLNGQEDRFLSGSWDKRLLEWDLQTGDIVNEFKKSRSELSSLEMRPLYSSVDVSGNVNSGKENENADDDMDSLFGDEDEDEKQDAGNEPVETGDGSNGEENKEQISEESLNIVYDESVFMTSGLNGSVHIWDRRMTQSPALSLERGAGVPPWCLSACWGVDGDHVYAGRRNACVEQFDLKMPSKPIHNLKLPSISGPVSCVKAMPNNKHLLCASRDNIRLYNVEIAVDASNSTTKSSKVPFLIVPGHHGGIISNLYLDPTSRFIISTSGNRGWQGNSTDTTLIYDIDLE", "function": "Required, directly or indirectly, for TATA-binding protein function at particular promoters. May promote a functional interaction between SPT3 and TATA-binding protein. Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs).", "AFDB_id": "AF-P38915-F1-model_v4" }, { "swissprot_id": "Q9TU31", "sequence": "MGAVRIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCQKRLKEVLQRPADIMESDKGWASASTSGKPKKEKASGKLYPESEEDKEVPTGSRHRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPTAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLGLPLSPRLLPAAAATTTATTNGHPPIPGHTKPGAPTLPATPPATAAPKDDGFLNGSCSGLDEEASAPERPPALLQEEWETVM", "function": "Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.", "AFDB_id": "AF-Q9TU31-F1-model_v4" }, { "swissprot_id": "Q9D2N4", "sequence": "MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNIELNVARLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSREPLHPMFPDQPEKPLNLAHIVPPRPVTSMNDTLFSHSVPSSGSPFITRSSPPKDSEVEQNKMLARAAPAFLKGRGIQYSLNVADRLADEHVLIGLYVNMLRNDPPCMLESSNRLDEEHRLIARYAARLAAESSSSQPTQQRSAPDISFTIDANKQQRQLIAELENKNREILQEIQRLRVEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKEEELKQGTQGASSPRSSPSHTISRPIPMPIRSASACPTPTHTPQDSLTGVGGDVQEAFAQSSRRNLRSDLLVAADSITNTMSSLVKELNSEVASETESTVDSEFSRPQFEDLAPSPTSEKAFLAQIHSRKPGYIHGGAASTTHGDMVPEDGDPYTQPEDGNYENESVRQLENELQLEEYLKQKLQDEAYQVSLQG", "function": "Involved in synapse maturation and required for normal muscle function.", "AFDB_id": "AF-Q9D2N4-F1-model_v4" }, { "swissprot_id": "Q9P6Q6", "sequence": "MDLKGLLHEENELPSIEKRKIDENAVEHDKVERKRTKSVAVPKIEMNFLNKPIVPDTTKVISNFLTHYLITEPVEHVEIEAKLGTLIDLETQNRFEFPVMNETILNPEFNLRTRFESDMTASEHKYLNEFLNQAFRDSQKPGRLPFAYKHTKQVDLFYETEDNSRDKIRVSKNQSDNQVLACVKKRRVADLFLYCPNDAFDIRISISDELPVSMPSGNQQPSLTRLKDRVGYVHQEIKIDLTKTTQNDPVYDTTERHELEVEFGNIADLRDRAQKAKDGMEAPLFRRVQLFMDNVRILRREHS", "function": "First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.", "AFDB_id": "AF-Q9P6Q6-F1-model_v4" }, { "swissprot_id": "O32242", "sequence": "MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHHLNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL", "function": "Represses the transcription of the sdpIR operon and of several other operons that probably contribute to delaying commitment to sporulation.", "AFDB_id": "AF-O32242-F1-model_v4" }, { "swissprot_id": "Q9UJV9", "sequence": "MEESEPERKRARTDEVPAGGSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF", "function": "Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.", "AFDB_id": "AF-Q9UJV9-F1-model_v4" }, { "swissprot_id": "P40893", "sequence": "MVESKNTELSQGTWLNKPKSVFQEAGKVTLETDEKTDFWRETFYGFTRDSGHFLGVETGSAFTAQVRVQGSYESLYDQAGIMVRIDDGHWLKAGIEISDGHAMLSSVLTNGKSDWSTAVYGGNARDFWLRVTVEKGVLRIQVSSDKKTWPLVRLAPFPTSDHYLVGPMACTPERGGLKVTFSEWSLTAPLGKALHDLS", "function": "Functions in the galactose metabolic pathway via the GAL83 protein and that it may control the level of ENO1.", "AFDB_id": "AF-P40893-F1-model_v4" }, { "swissprot_id": "Q5PB22", "sequence": "MKKVVLAAGGTGGHIVPAALLCQVLADRGYRCVLYTDQYFLQYTARFPGIKGYVLLPLCKRSGGAVRLLKFCALLAYSCVLSYIKLRSLKPDLVIGFGAYASFPVLLSAWLMSVDAVLHEQNSVMGRVNRVFAGYARVIACGLPLRTVGNKLAHKVAHVGVPTDVKKAVKRPLAGDSINLVILGGSQGLCTFGKTFALAIAELPTNIRGRVFVTQQCGKGQLEVITELYARHGIKHKLSGFFTDMQNIIGEADLIISRAGATTIAEVMAAGRPAIYVPYERSSCSHQLYNAQLIESLGAGLCIEERTLDVSSARDALTNLLGDRNKLQEMSCNAAKHAMPDADAQFCAIVDGLLKG", "function": "Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).", "AFDB_id": "AF-Q5PB22-F1-model_v4" }, { "swissprot_id": "P57775", "sequence": "MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP", "function": "Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.", "AFDB_id": "AF-P57775-F1-model_v4" }, { "swissprot_id": "O18276", "sequence": "MRRSKTRRIFHVSITLLLVSTIFCQNGTKPHNNSTSDQMSSSWSNRSQTMYSNASSLLSDLLLDYDIRLRPGFGGDALLLTMDIIIASFDSISEVDMDYTLTMYLHQYWTDERLRWSNEIPIDEMTLSGEFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGMRLTSTLSCSMNLRNFPLDSQNCTVEIESYGYTTSEVLMKWNYPLAVHGVEQADVPQFTITGFHTEDSIVSTATGSYQRLSLVFQLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRQSLPRISYVKSIDIYLVMCFVFVFAALLEYAAVNYSYWGRERGKGGGGNEWPVNGANKEDRESAVNVQKWVPSGLMDGVPQPQDRRVEALEEAMSTSNTAAQNNNFESTSKPKKRSSSPIPPLCRAGNTISEESESPDYPRYSTTSLKGARPHASLNHKTHHLKGRSSARAKRRMTLARMNVSMKQSISGIGRRARKVIPTIRVRDVNLIDKYSRVVFPVCFIVFNLFYWSYYMMVPS", "function": "GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel.", "AFDB_id": "AF-O18276-F1-model_v4" }, { "swissprot_id": "Q8BHE0", "sequence": "MPKYKQRRRKLKAKAKRMSKKKEAAVVSPKLLTPSPPLPEPERVVTSAADIPQSRNWLRPSWNLRFPNIKDAINLWTNRAWCIYSCCQTCVAQSLEVLKDALFPSRVYHRELHSLKQQLCVLKRELCKLRENLKSISENSSCSSCCHKCCPSDKLTTVPACAPTTNGESQTVLSSTQPQPANHPPSPPPLPPPPPPPPPLPPPPPPLAPLLLRKSGTTKALQVEPLKKDGPMHITVKDLLNVKLKKTQSVDERKKLVPSPPEERTPLVTVSDLQHVTLKPNSRVSATRIKNVLITPGKSQIDLRKLLRKVQVERSPGGTPLNNKENMDTGTGLTPVMTRALRRKFQLAHPQSPTQSLPLSTSSFDEQN", "function": "Plays a critical role in cell cycle progression.", "AFDB_id": "AF-Q8BHE0-F1-model_v4" }, { "swissprot_id": "J7SZ64", "sequence": "MKFWRKYTQQEMDEKITESLEKTLNYDNTKTIGIPGTKLDDTVFYDDHSFVKHSPYLRTFIQNPNHIGCHTYDKADILFGGTFDIERELIQLLAIDVLNGNDEEFDGYVTQGGTEANIQAMWVYRNYFKKERKAKHEEIAIITSADTHYSAYKGSDLLNIDIIKVPVDFYSRKIQENTLDSIVKEAKEIGKKYFIVISNMGTTMFGSVDDPDLYANIFDKYNLEYKIHVDGAFGGFIYPIDNKECKTDFSNKNVSSITLDGHKMLQAPYGTGIFVSRKNLIHNTLTKEATYIENLDVTLSGSRSGSNAVAIWMVLASYGPYGWMEKINKLRNRTKWLCKQLNDMRIKYYKEDSMNIVTIEEQYVNKEIAEKYFLVPEVHNPTNNWYKIVVMEHVELDILNSLVYDLRKFNKEHLKAM", "function": "Catalyzes the decarboxylation of tryptophan to tryptamine. Tryptamine is a neurotransmitter that induces the release of serotonin, which is suggested to modulate gastrointestinal motility. Therefore, the tryptophan decarboxylase from the gut bacteria Clostridium sporogenes (strain ATCC 15579) may influence host brain and behavior. Has weak activity with tyrosine. Activity against phenylalanine is undetectable.", "AFDB_id": "AF-J7SZ64-F1-model_v4" }, { "swissprot_id": "Q7TS68", "sequence": "MYVFPKISLRPEVENYLKESFLNEEAVSASSRQEAERKFETLLLRLSHPPSMTTVRVNTHLGSVQHVRGLLLEELQKQFGESSIPVVQHPALPDVLLIPMTGPRKNIERQQGEVIVGAQCGNAVLRGAHVYVPGIVSASKFMKAGDVISVYSDINGKCKKGAKEFDGTKVFLGNGISELSRKDIFNGLPDLKGIGIRMTEPIYLSPSFDNVLPSYIFLQNLPSTVVAHVLDPQPGEKILDMCAAPGGKTTHTAALMQDKGEVIALDKILTKVNKLKQNASLLGLHSIRAFCFDATKALKLDTTDGIEGGPPFLPESFDRIILDAPCSGMGQRPNMACTWTLKEVTSYQPLQRKLLHVAVQLLKPGGVLVYSTCTITLAENEEQVAWALRTFPCLQLQPQEPQIGGEGMVGAGLTLEQLKQLQRFDPSVVPLQNMDTDSLGEARREDMIWLANKDCIGFFIAKFLKCQSTKAKVSQK", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates.", "AFDB_id": "AF-Q7TS68-F1-model_v4" }, { "swissprot_id": "Q568P1", "sequence": "MNCSSTAVLLETVNFAAEKHRNQRHKDPEGTPYINHPIGVARILSHEGEITDVEVIQAALLHDTVEDTDTTFEELESVFGATVARIVQGVTDDKSLPKAERERQQVEHAPHCSHQAKLVKLADKLYNLRDLNRCTPEGWSAQRVQEYFEWASQVVKGLRGTNAAIEEKLQQLFLERGVKL", "function": "ppGpp hydrolyzing enzyme involved in starvation response.", "AFDB_id": "AF-Q568P1-F1-model_v4" }, { "swissprot_id": "B7KLH9", "sequence": "MSEDNRPLEEQLGNRAESPNTPESVREDNSKSQNNHLNQPSSTPQTPETTADNTFVESELLQDSQGIEKLLATLAEQIGSTQEGQEILGQLQPLLTNLIQQNESLLQTNQSLKDQLEEQNQQIDAAKRRYIGLAAEFDNFRKRTLREKEELEKQAKRKTLSELLTVVDNFERARLQIKPSNEGEGEIHKSYQGVYKNLVDSLKRLGVSAMRAEGEPFDPMYHEAMLREPTNDFPEGTVIEQLVRGYLLDDQVLRHAMVKVAAPKEPDSSETESTSESVSDVQQPTT", "function": "Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.", "AFDB_id": "AF-B7KLH9-F1-model_v4" }, { "swissprot_id": "Q95Q89", "sequence": "MTSVYESLLSDYPDKGVIGKPEIRDTETEIIEKLRTLYNHFVQAKQTGKPIFVLIGAGVSTGSKLPDFRGKQGVWTLQAEGKHAEGVDFQVARPGVSHKSILALHKAGYIKTIITQNVDGLDRKVGIPVEDLIEVHGNLFLEVCQSCFSEYVREEIVMSVGLCPTGRNCEGNKRTGRSCRGKLRDATLDWDTEISLNHLDRIRKAWKQTSHLLCIGTSLEIIPMGSLPLDAKSKGIKTTTINYQETAHEKIVETAIHADVKLILYSLCNALGVNVDLGDDLPDEVPIPLKIS", "function": "NAD-dependent protein deacetylase.", "AFDB_id": "AF-Q95Q89-F1-model_v4" }, { "swissprot_id": "Q20574", "sequence": "MRDRLNEFQSRVTDRFDEVELSPARPPSAAEYVDRRFEEVRNAIASVRGEIEKLRRDQQHVLALTIADPRDKNILENQIGTIRRRTGDLRKLVRQAEDDFLEFTKQVQSVTEKRMRQNQLELLKDNLNKLINLFNETHQDYKSRVSVRVRRQLQTVGQDLTDEDINRIMENSGSEQLFFREVNPLSVSGQAAYEDVKKRHGEIKDLENNIAMLEEIFLDLQHLTEAQDEMVTNIDNNVENGLEQVKQGSANVKTAVEYKKSAMRKKICVAAILITILLILIIVAIILAVVLSRGNNNNK", "function": "Potentially involved in docking of synaptic vesicles at presynaptic active zones.", "AFDB_id": "AF-Q20574-F1-model_v4" }, { "swissprot_id": "B9WLY5", "sequence": "MISMNPIMIRNNLSRSSSPAAPPITNHTSTVDYFSLKPKLSLDTSSQNDSISTQSSNNDDTHSDQQDHTLYTHNHYFDDDYDDDEDEDFDIRDQLLDPFDKITISNCNEEYYSPLTPFDDQTTSPQDSIISSKSSNKSTTVVPPPQFQLTLPKLTTYSFLIVDDNIINLKILNRILLKLFPKCHIVQIQDSKLVKDILHKQPFDSIFIDIEMPDVNGIDIAQFVRQDSKFDDMGMVAVTTRNSTQDLELFKQCGIDCTFHKPLNYSLDFMANSIDDIIITRKNKI", "function": "Required for stress adaptation, morphogenesis and virulence.", "AFDB_id": "AF-B9WLY5-F1-model_v4" }, { "swissprot_id": "P25748", "sequence": "MITIRDVARQAGVSVATVSRVLNNSTLVSADTREAVMKAVSELDYRPNANAQALATQVSDTIGVVVMDVSDAFFGALVKAVDLVAQQHQKYVLIGNSYHEAEKERHAIEVLIRQRCNALIVHSKALSDDELAQFMDNIPGMVLINRVVPGYAHRCVCLDNLSGARMATRMLLNNGHQRIGYLSSSHGIEDDAMRKAGWMSALKEQDIIPPESWIGAGTPDMPGGEAAMVELLGRNLQLTAVFAYNDNMAAGALTALKDNGIAIPLHLSIIGFDDIPIARYTDPQLTTVRYPIASMAKLATELALQGAAGNIDPRASHCFMPTLVRRHSVATRQNAAAITNSTNQAM", "function": "Repressor of the mgl operon. Binds galactose and D-fucose as inducers. GalS binds to an operator DNA sequence within its own coding sequence (corresponding to residues 15 to 20).", "AFDB_id": "AF-P25748-F1-model_v4" }, { "swissprot_id": "Q8L3A1", "sequence": "MNMQILWIIIAIICSYLIGAIPFGYIIPKLFKGIDIREHGSKNVGSTNVLRVLGAKYGIPTFLLDCFKGALPIIIIRYMLGMPELFLISDTYDISIVFGAAAAIGHIKSIYIGFKGGKAVATGVGAVIAINPIIGLSGIGLFFIVAFSTKYVSIGSVVASFSVAVMMWIGVLIKEIWIPVPNLTISYESQIINLVAISLIVLLIIYMHKKNFIRLMNGTENKIGQKKIQNITK", "function": "Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.", "AFDB_id": "AF-Q8L3A1-F1-model_v4" }, { "swissprot_id": "Q54K56", "sequence": "MKLKFIFLILFFIIGNSIGIKISKEINKIKLNDISIDGEILLNKSSDSSSSQSSKIINIWPMPKKVLNGDITVYISPHFQFTTNLTKSTTLKKAMDRYYKLIFTEDSKSHSGISILNEIKILVKSEDETLQIGFDESYEIYIDDSGDDGGKIIAETVYGAIRGLETLYQMIGFDYQREYYQIKHCPWIIQDSPRYPHRGVMLDTSRHFYSVDVLKEFIEALAYNKFNVFHWHAVDSQSFPLTSTTFPKITKGSWSSQEIYSTRDIKEIIQHAKEYGIRVELEIDMPGHAYSWGIGYPSVLPANFSHSIQCQQPCPTECNIPLDVSSKESYVIAMGLLEEFNGASMFNESFFHIGGDEVAYSCWNNSLRIVDWMKRENISSFQDAAIFFEIKAIEQLIQLGKTPVMWEDAYLLFGSSGITEKLPEEVVVQIYHDPLLALNTTRDGYKTLQSPYWPYYLDNPSVDWEKVYEFEPSNGIHEKRLRLLLGGETCMWSELVDASNLFAKVFPRAFATAERLWFSIENSNSTTFAKPRLERFRCFLLERGIGAAPLNSTSPDDPNSCYSS", "function": "Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines.", "AFDB_id": "AF-Q54K56-F1-model_v4" }, { "swissprot_id": "M2YMU2", "sequence": "MEFTLQQDKVRALDDDMLVVKSESGGAGLDRGDDESQYPHGLKLAVLMTCVFIGMFLVALDKLIISTATPAITNEFHAYSDVGWYGTAYLLTNCATILLFGKLYTFLDVKATFLSAVLLFEVGSAVCGAAPNSIAFIVGRAIAGLGAGGIQEGVLVIIVCAIPLSKRPAYQGLFGAVYGVSSVIGPLLGGAFTTHVSWRWCFYINLPFGGLVALAVFFLLKVPGGGAMKSSWKHKVKELNIEGLVALLPGVISLCLALQWGGFTYSWSNWRIILCLTLGLVLLIAFIFIQVWRPKTATVPPHIFCQRSIFTGFWVSALLGAHQTIIIYFLPIWFQAIKGDSAVQSGIHLLPFVIAIVVSSILTGVGTTKTGYYTPFLIIGTVTAAIGAGLFLLLQPHTTTGQWIGYQIVYGFGLGGCYQAPNVAAQTVLSKDEAPVGTALILFATTLFGAIFVSVGQNVLDQQLATKLAGLAGFDITPQQINTAGVTGLFQMVPQGLHNAVLYAYNSALRRTFLVGLILACLTILGSLGMEWRSVKKEQQKQQEKAMENEQEEAAKTQKHKYALDTDENFGV", "function": "MFS-type transporter; part of the gene cluster that mediates the biosynthesis of an emodin derivative that may be involved in black Sigatoka disease of banana.", "AFDB_id": "AF-M2YMU2-F1-model_v4" }, { "swissprot_id": "Q54QV3", "sequence": "MGSTTQMSDYLVSTTTTSSASSMVTMTSQIENNSLNSNDNTNTTNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNNGGMVGVNHKTHKKTASIGGGKNRAILHDFTFSYFIPNQNRSEDNSNENELGLNNHNVQHQGPIIHLTKNLLHFYKKCNSNFNYISSLNPRRVLTHPSEPLSNDGYDNVNSDYIVYVNDIITNNESGQKYKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQNNFRGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPAIKIIDFGSACYEKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFLGLPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLKSEEDYQRDSKTTLLPSKKYFNYKTLPEIIQNYGFKKSMSPQDIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKEHPFITGQPYNGPFIPDPSKKRHFTYSQPKQIPQHSMLNGNQILNQHQLFQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHNQFQQQQQQQQQQQQSSSQQHIQIQPLQLFSTPYTSTNNTPNLSSSNSGSSLNNLKKLNLPPFKQQQQQQFSTSQNSDSFNFPNESFSPRGIYIPSSASNIQQQQQPININNNQNGVGSQVSQLALGQSPSLFGTPTNIYPPYSSMYNNSPVATPNSLSFYGSSWGSDSSSISLNPSTPTQKQMFQQQQYSNNNNNNNNNNNNNSNNNNGNNTNNINSNNNNNNVNRRNRSKSDIPSDSFSSSEGMDPQFNLYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQYQQQFQTLQDLNIEGEKPPIYPNSPHRKRSHSGYLDQYANGYNSQQTNNTQQQQQQQQQQQQQQQQQQQQQQHPSFFSTRMHLDHFNGGSRYRSQSYGDQQFQQQQYKQQQKNLHHQQQQQQRFMQVGSPPTSHLSPPIPQSPLMMSQPLHQTYIPQQQQQQQQQQQQSQPTPFTPQMISQEPISPALMGDASSIWNPSPTEELLFTIDLPNQQNTPHLTPSNSSTNLLGKSASSPLKNSSGGAIPPTPTIPINMEEINNGFSKFHFNDQPSWNSNGNSPWMIQQQQQHQQGFNGNSESMYNDDLIGFSPYNNYSNDYRPQLFNKQSPPSSYNSNKSFYGGSGGGGNNNNNNNSRPTNQNFSNSLLPSQQQNVIFPQNSPPSSYNSSNSLSKSGGNTVKNNSNTGGRPRGDSMKQRFNSTNNLLSGGSYQYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYKKDTPSLMMSPPMNGLKTSSEIGIPSEEIRYQYQQQQLQQQFQQQQQQQQQQQIQQQLQQQQAPPQNRKQVVIGSYRET", "function": "General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development).", "AFDB_id": "AF-Q54QV3-F1-model_v4" }, { "swissprot_id": "P33229", "sequence": "MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV", "function": "Toxic component of a type I toxin-antitoxin (TA) system. Upon overexpression inhibits growth and reduces colony-forming units in both the presence and absence of the Rac prophage, cells become filamentous. Has deoxyribonuclease activity (probably endonucleolytic), does not digest RNA. Its toxic effects are neutralized by sRNA antitoxin RalA, which is encoded in trans on the opposite DNA strand. Has RAL-like activity.", "AFDB_id": "AF-P33229-F1-model_v4" }, { "swissprot_id": "P50427", "sequence": "MPRPRPLLLAVMAATLADIILAADPAPAGPAPRPPNFLLIMADDLGIGDLGCYGNKTLRTPHLDRLAREGVKLTQHLAAAPLCTPSRAAFLTGRYPPRSGMAAHGRVGVYLFTASSGGLPPSEVTMARLLKGRGYATALIGKWHLGLSCRGATDFCHHPLRHGFDRFLGVPTTNLRDCRPGAGTVFGPALRVFAAGPLAALGASLAAMAAARWAGLARVPGWALAGTAAAMLAVGGPRSASCLGFRPANCFLMDDLAVAQRPTDYGGLTRRLADEAALFLRRNRARPFLLFLSFLHVHTAHFADPGFAGRSLHGAYGDSVEEMDWGVGRVLAALDELGLARETLVYFTSDHGAHVEELGPRGERMGGSNGVFRGGKGNNWEGGVRVPCLVRWPRELSPGRVVAEPTSLMDVFPTVARLAGAELPGDRVIDGRDLMPLLRGDAQRSEHEFLFHYCNAYLQAVRWHNGSAVWKAFYFTPNFAPAGANGCFSTHVCLCAGPAHVTAHDPPLLFDLTRDPGERRPLTPEAEPRHREVLDAIDAAARAHRARLRPAPDQLAPRHLMWKPWLQLWGGGGAGGGAGAQDDSGHAHGDGSHAHDDPGHAQDRGDDDAHYGGHATTRTQATPR", "function": "Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.", "AFDB_id": "AF-P50427-F1-model_v4" }, { "swissprot_id": "P40791", "sequence": "MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRVLLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEAKYNKIDEEFQNMMQRNQMAIGGAGAPRQLPNSSYTLPVSVPVPGSYGDNLLQASPQMSHTNISPRPSSSETDSGGMSLIIYPSGSMLEMSNGYPHSHSPLVGSPSPGPSPGIAHHLSIKQQSPGSQNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQRQSQTSLNTPVVTLQTPIPALTSYSFGAQDFSSSGVMNSADIMSLNTWHQGLVPHSSLSHLAVSNSTPPPATSPVSIKVKAEPQSPPRDLSASGHQQNSNGSTGSGGSSSSTSSNASGGAGGGGAVSAANVITHLNNVSVLAGGPSGQGGGGGGGGSNGNVEQATNLSVLSHAQQHHLGMPNSRPSSTGHITPTPGHDKYEGYPYRALMGHNPRWNLNFAGAPSSDQDVRLAAVAVQQQQQQPHQQQQLGDYDAPNHKRPRISGGWGT", "function": "Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers. Essential for myoblast fusion and consequently muscle formation in adults. During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription.", "AFDB_id": "AF-P40791-F1-model_v4" }, { "swissprot_id": "Q09225", "sequence": "MGNMRRLLIFAVLVILTVISNSKSSYKYDGSLFSSKELDYDETDTKAMGSVFSRYMSDSDAQLILDLDFFRHFFNYAEAYRDGAEEGNLELMKYAVEMVEKLKSFDISMACVGDMMHLAWTGVEYATHVEEHKNCSDCKCTPLFQQKKSERHWIFNVFDAMGKVPAGIMSGNNLWVGSWSTCRKIDVVKNAQGQKWKGQYCLATIDAYERDNPLVYFGNMMSGPPDKHCYDKTVKNVTDDGFCFALFPVLKFGVCMPNTCTNHDVKQMLSFAIRATEGAVGTKSVCNVDVECRAESYSDAMSENGLAMFALYLLIATVVLVTFGTLYDLFIVSKAPQDEKNSSAFNHPFIKFILAFSMYTNGSEILQSKKNDREINSLHGVRFLSMCWIILGHTYYYIGTSLTTDNLVPTLINFPKQFHTQIIVQAPLAVDSFFFLSGMLAAFSFFKKTMKADPNHPPKLSAFNWQTWPMYYYKRYIRITPTYIIVMLFDVTLFTYISNGPFWRPIERQGCSIAWWTNLIYLNNFLLQDQECCMGWTWYLANDMQFHIFLMPLLVIVFLKWGMKVGLGLSTGLIALSSLIRLIITQIYGYPPAPILTAKLQIVYQLNDYWNDVYVRPYIRCTPFIVGIVVAYLLNAWTTREQKDLKIKLERRTVIICWCTSTVLGLYSVFGLYWFAKTGDISKPWEILYTIFGTPAYALALGWVVFACTTGNGGPVDTILSWRLFVPLSKITFCAYLLHPIMLQIYNLSRPQPFHFTTFIQMIRYTVEAVFASYTIAFFFSLAFEKPLNKIDEMLFNSKKMMNGENGNTTEMVPLNKIRNSD", "function": "Plays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development.", "AFDB_id": "AF-Q09225-F1-model_v4" }, { "swissprot_id": "B2IJX5", "sequence": "MHIDWWTLGLQAINVLILIWILSRFLFKPVAAIVEARRASIARLLDEAHATRVAAEAEREKARQEVTSLATARAAALQKAEDEAKAETETILANARSEAGKLREAAKADIARARQDEAAAMADHASQLAVDIAGKLLSRLPEEARISGFIEGLAQGLAALPEAIRTNIGATDAPVQLKAARALTEAETQACRVRLSEALGHPAEIAVDVRPELIAGLEIDMPHAVVRNSFRADLTRITAALIQTGSMQTGQEAPRPETP", "function": "Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).", "AFDB_id": "AF-B2IJX5-F1-model_v4" }, { "swissprot_id": "P23300", "sequence": "MDTLVMENSAPAQAASSPEFLFTSGQGTLSATDWASLITTPACEWPLLEQQIASALAAARPAGQANPLLIGCLRVRPGGSSCLYVPAAMSGDRPVPAAQAPVTAAMANQVVEANRVISVQSTPPASEFQASVSAALDAFAQGRLAKVVLSRKLTLTLHQPADPTQVMARLMAQNPHAFHFSLPLGQGRRLLGASPELLLRVSEGEVFTHPLARSARRASEPAQEQMVARDLLASRKDQHEHKLVIDEIRRVLTPHCRELAIPSSPSLMSTDTLWHLGTPIAGRLNGGEASVLSLACQLHPTPALCGYPTELARQFIREQEPFRRALFSGIVGWCDSQGNGEWAVVIRCGVLDGHQVELFAGAGIVAGSDPPWSGPRPGTKLGTMLKALGLDLEVAQ", "function": "Involved in the synthesis of amonabactin, a phenolate siderophore containing 2,3-dihydroxybenzoic acid (2,3-DHB).", "AFDB_id": "AF-P23300-F1-model_v4" }, { "swissprot_id": "D1ZEM6", "sequence": "MAQAQIGTPLLTTRQAEELHKSILAYLSSKNLASTAATLRDELPDLAEVTFDTEKAKKYEGLLEKKWTSVVRLQKKILDLESRNTLLQSEIDNATPSSLSRRTQDPTNWLPKAPPRYVLESHRLPVTCVAFHPVFTSLASGSEDYTIKIWDWELGELERTIKGHTKAVLDVDFGGPRGGTLLASCSSDLTIKLWDPSDEYKNIRTLPGHDHIVSSVRFIPSGAAGAPASGNLLVSASKDNSLKIWDVTTGYCVKTILGHVDWPRAVCPSHDGRYLLSTGSDKSVRLWDLAGGRDAECRLVMFGHENYNLCCAFAPPTAYAYLAKLAGLDRPPPLGASAEFMATGSRDKQIRLWDGRGNCVKVLVGHDNWVRGLVFHPGGKYLLSVADDRTMRCWDLSQEGKCVQTLTGVYEGFVSCIRWAPPVVKDADAMAANTKSGGTGPLADTVVAARRRAATVGSVNASVQIRCVVATGSVDGTEGKVRIFAN", "function": "Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.", "AFDB_id": "AF-D1ZEM6-F1-model_v4" }, { "swissprot_id": "Q2JJV2", "sequence": "MNIVVLAGGRSAERQVSWVTGKACKRALEDLGHRVKVIDPDEDLPLRLWQERQAGCDFVWIALHGPGGEDGVVQGMLDWLGLPYQGSGPLASALAMDKLVSKQIFRAAGIPTPDWQVWDDQNPLTWADCAAELGSPLVIKPSNNGSTVGISIVRDERSFAQGLELARSVSSRIFLERYVPGKEITLSILSGQVLPAIEIIPAQGDFYDYEAKYAPGGSRHLIPCSLSPAGLARCEAAGLKAYQALGCEGLARVDLRVDPEENPWVLEVNTLPGMTPTSLCPDAAAALGWTFTELVERMLQDALQKAQLTGSRHPQSSSATLGNAP", "function": "Cell wall formation.", "AFDB_id": "AF-Q2JJV2-F1-model_v4" }, { "swissprot_id": "Q09626", "sequence": "MFSFFTYFLLSALLLSASCRQPSMDTSKADRILREIEMETELENQLSRARRVPAGEVRACGRRLLLFVWSTCGEPCTPQEDMDIATVCCTTQCTPSYIKQACCPEK", "function": "Probable insulin-like peptide which negatively regulates synapse development at the neuromuscular junctions. Probably acts as a daf-2/InsR agonist ligand to prevent dauer formation under optimal environmental conditions.", "AFDB_id": "AF-Q09626-F1-model_v4" }, { "swissprot_id": "Q54WD3", "sequence": "MVRNSEITLEQIFKEGRINLENDDYNCVICSFPLFDGLQCKRGHGACKSCWEKIIGENGKKECHSCRISIKSLDDLSKNLYLEKEIFKQKVACLNNGREKFGNTLVIKSDGGCKRQDIPIEKLLHHIKNECGYLLIDCKYSRDCKYYKQISLEQHQNECQFMSIHCPALCGKKDSRMNINKHLETPNSCKPLISINNSNNSNGNGNGIDDESIIKLSNSIVEIQKSYQNQIKKIKENSESEIAALKDSLYYSKSRIKNLEDEVEELKDRFSTLESMINKLDDSATSRSGTILINGWKMKLKSLDVGHSIVEEQFYIGTNRFYIRIYPFGDSYDNQGYVTVKLGRIDGEEYHLDIGLKVSIKGFDNKKKVLLSYYPGDIAHNIDQLVETWETSKEFKMILHFKVDLKPKIK", "function": "Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.", "AFDB_id": "AF-Q54WD3-F1-model_v4" }, { "swissprot_id": "P26725", "sequence": "MAKGGSLYIVGIFLPIWTFMIYIFGKELFLIRKYQKIDSTYTALSQRVKEQYDTSRRRNYFPKVKLSRNSYDDYTLNYTRQNDSDSFHLRENATILMLVRNSELEGALDSMRSLEDRFNNKYHYDWTFLNDVPFDQDFIEATTSMASGKTQYALIPPEDWNRPQWINDTLFEERLRVMEDEGVLYGGSKSYRNMCRFNSGFFFRQSILDNYDYYFRVEPNVKYYCDFPYDPFRVMRLKGKKYGFVISLYEYEETIPTLWDAVEEYLVASEETILRKEDSAYAFLTDSGLVGKHYPVVEANSDYNLCHFWSNFEIGDLNFFRSDEYKHFFETLDAKGGFYYERWGDAPVHSIGVSLLLRPDEIIHFDELGYFHSPFGTCPASYAVRLDQRCRCKSDDESVIDITPHSCLMRWWKNGSGKYFLKEEQDEI", "function": "Possible glycosyltransferase involved in N-linked glycosylation. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.", "AFDB_id": "AF-P26725-F1-model_v4" }, { "swissprot_id": "P12027", "sequence": "MIMGGVRELLLVVMTVGVVKVSCYPVGKSQKQDQVSLQRRLGELSSNDVSIVHALALLRSIGSDAKQAREEYLETNEVESQASPNHGSSPANDALSSEEKLRRVSSDDAATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDATSEAATGPSGDDAMDI", "function": "In response to egg activation, PSGP is discharged by exocytosis into the perivitelline space, where it undergo rapid proteolysis into glycotridecapeptides. During fertilization and/or early development the glycotridecapeptides prevent polyspermy or are involved in the formation of a fertilization membrane.", "AFDB_id": "AF-P12027-F1-model_v4" }, { "swissprot_id": "Q3JCY7", "sequence": "MIVGIGTDIVQVSRMTALLGRYGERFPRRILTGDEFKKFSVSKQPAYFLAKRFAAKEAAAKALGTGFGSGLRPCHIGVGHTERGQPFLEWQGRANELVRILGVSRGLLSLADEKEYALAFVTLLAEREGAKPGLSLERALNSLKLSGNGNGVTD", "function": "Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.", "AFDB_id": "AF-Q3JCY7-F1-model_v4" }, { "swissprot_id": "A0A168WVR6", "sequence": "MDESNLLQGISMIDLRSPDAILSDYAKRYAHLLPELSPQLQQRMAYMPEPDAPRLPLTKPAWLSDRSCTLTPGQAIDRAQGALLGLAIGDAVGTTLEFRRRDQGQVSDMVGGGPFRLAPGEWTDDTSMALCLADTYASQGKFDFATFADAMVRWYRQGENSANGRCFDIGNVTRRALEGWEAQGLAWMGNLEASTAGNGSLIRLAPTAIFRRHSLSATWWESVTQSSVTHRAIEVSECCKLFGAQLHLALNGADKEEALSPKVRPLQPRALIINAGEYKHKTREQIRSSGYVVDTLEAALWAVWNTDNFRDAILLAANLADDADSVAATAGQIAGALYGVSGMPPEWVAKVAWSRHICELASRLFELAPQGDEMDELLSGSE", "function": "Orphan immunity component of an interbacterial competition system (also called effector-immunity systems); this bacteria does not encode an identifiable cognate effector protein. Expression of this protein in E.coli partially protects the cells against competition by wild-type S.proteamaculans. Probably acts as an arginine mono-ADP-ribosylhydrolase, mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. Probably de-ADP-ribosylates FtsZ and possibly other proteins (Probable).", "AFDB_id": "AF-A0A168WVR6-F1-model_v4" }, { "swissprot_id": "Q9ZPE7", "sequence": "MYLLVFKLFLFLSLLQISVSARNLASQEPNQFQLLKYHKGALLSGKISVNLIWYGKFKPSQRAIISDFITSLTHTSPTSKTLHQPSVATWWKTTEKYYKLATPSKNSSPLSLTLGKQIIDESCSLGKSLTDKKIQTLASKGDQRNAINVVLTSADVTVTGFGMSRCGTHGHARGLGKRGSKFAYIWVGNSETQCPGQCAWPFHAPVYGPQSPPLVAPNNDVGLDGMVINLASLLAGTATNPFGNGYYQGPQNAPLEAASACPGVYGKGAYPGYAGDLLVDTTTGGSFNAYGANGRKFLLPALYDPTTSACSTMV", "function": "Required for cell expansion in leaves. May mediate brassinosteroid (BR)-induced leaf growth. May play a role in the control of BR responses in roots. May be involved in signaling processes that coordinate BR responses with environmental or developmental signals.", "AFDB_id": "AF-Q9ZPE7-F1-model_v4" }, { "swissprot_id": "Q9L0T8", "sequence": "MDNSRTRPRVGHIQFLNCLPLYWGLARTGTLLDFELTKDTPEKLSEQLVRGDLDIGPVTLVEFLKNADDLVAFPDIAVGCDGPVMSCVIVSQVPLDRLDGARVALGSTSRTSVRLAQLLLSERFGVQPDYYTCPPDLSLMMQEADAAVLIGDAALRANMIDGPRYGLDVHDLGALWKEWTGLPFVFAVWAARRDYAEREPVITRKVHEAFLASRNLSLEEVEKVAEQAARWEAFDEDTLAKYFTTLDFRFGAPQLEAVTEFARRVGPTTGFPADVKVELLKP", "function": "Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).", "AFDB_id": "AF-Q9L0T8-F1-model_v4" }, { "swissprot_id": "B1VTI4", "sequence": "MPMNRREMVMATTGAALAAAAAVPLLSGGEGEGAAEAAAAPAKATGRGREHTERYLGRSIRVAAPADGGGVFIDGRPLHIMKFADDAYLSSMCHYEMAPTPLHAARRAVEELRGAALQPSTHGTHVTHL", "function": "Involved in the transfer of copper ion to the apo form O-aminophenol oxidase GriF in the grixazone biosynthetic pathway.", "AFDB_id": "AF-B1VTI4-F1-model_v4" }, { "swissprot_id": "Q0S7P8", "sequence": "MGITSTTDGDGITTVTVDYPPVNAIPSRGWFELADAVLDAGRNPDTHVVILRAEGRGFNAGVDIKEMQATDGYGALVDANRGCAAAFAAVYDCAVPVVVAVNGFCVGGGIGLVGNADVIVASDDAVFGLPEVDRGALGAATHLARLVPQHMMRTLYYTAQNVTAQQLQHFGSVYEVVPREKLDDTARDIAAKIAAKDTRVIRCAKEAINGIDPVDVKTSYRLEQGYTFELNLAGVSDEHRDEFVETGKPRSHSNNRKG", "function": "Involved in the final steps of cholesterol and steroid degradation. Catalyzes the hydrolytic ring D opening of (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA (HIEC-CoA) to (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA (COCHEA-CoA).", "AFDB_id": "AF-Q0S7P8-F1-model_v4" }, { "swissprot_id": "Q9UTI4", "sequence": "MAINNENELEYKLIKKNKNPKISNSKKKNSTRPALQDKTNQTLPIHQNQAFSNILPSDFSIIKTPETKTADDFPVNGYEGLNILKFDLELFYKLKPVATSTPKSCMRTGSNLFLNETVKHVPDERLVSNIKNTQTKDSITRDSAYYHRKTMTESIIKTLAAFDAEVDEIILF", "function": "Plays an important role in chromosome segregation during meiosis I by allowing meiotic rec8 to establish cohesion at the centromeric central core and thereby promote the side-by-side structure of kinetochores at meiosis I. Enables monopolar attachment during meiosis I. Required to facilitate kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Acts in collaboration with plo1.", "AFDB_id": "AF-Q9UTI4-F1-model_v4" }, { "swissprot_id": "Q08474", "sequence": "MLFEVFGEVLASYIVSSKTKGELAFPVNNAPPDSLVAINCVVLFLRSAIGSCSGAKELIRSSALELSCSSSCGLPATDKPGSFHSGALSKSILSANEAVVSKSSLSFLSSFVDI", "function": "Required for vacuolar fusion. Involved in the early steps of the fusion pathway.", "AFDB_id": "AF-Q08474-F1-model_v4" }, { "swissprot_id": "Q16927", "sequence": "MATDGITSRFGFNERRRTHNRNSCRILEDKMLAKLLLLALAGLTAAYQYENSFKGYNPGYKGYDAGYKGYGYDAGYKYNNQGYSYKNGFEYGYQNAYQAAFYKHRPNVTEFEFSSWMPNYEYVYNVTSKTMTALAELDDQWTGVFTRAYLVIRPKSRDYVVAYVKQPEYAVFNERLPYGYATKFYHDMFKFQPMPMSSKPFGIRYHKGAIKGLYVEKTIPNNEVNILKAWISQLQVDTRGANLMHSSKPIHPSKNEWNGHYKVMEPLVTGECETHYDVNLIPAYMIQAHKQWVPQGQLRGEDGQFIQVTKTQNFDRCDQRMGYHFGFTGYSDFRPNTNQMGNVASKSLVSYMYLTGNWYNFTIQSSSMINKVAIAPSLVNKEPALVYAQVNMTLNDVHPYDKVPMGPAEDLKVFVDLVYSYNMPSDKKNYVRPGNETSSSSSSSSSSSSSSSESSSSSSESVENPKISPVEQYKPLLDKVEKRGNRYRRDLNAIKEKKYYEAYKMDQYRLHRLNDTSSDSSSSDSSSSSSSESKEHRNGTSSYSSSSSSSSSSSSSESSSYSSSSSSSSESYSISSEEYYYQPTPANFSYAPEAPFLPFFTGYKGYNIFYARNVDAIRSVGKLVEEIASDLENPSDLPKSNTMSKFNILTRAIRAMGYEDIYELAQKYFVSQKERQVAQFSDKKFSKRVDAWVTLRDAVAEAGTPSAFKLIFDFIKEKKLRGYEAATVIASLAQSIRYPTEHLLHEFFLLVTSDVVLHQEYLNATALFAYSNFVNQAHVSNRSAYNYYPVFSFGRLADADYKIIEHKIVPWFAHQLREAVNEGDSVKIQVYIRSLGNLGHPQILSVFEPYLEGTIQITDFQRLAIMVALDNLVIYYPSLARSVLYRAYQNTADVHEVRCAAVHLLMRTDPPADMLQRMAEFTHHDPSLYVRAAVKSAIETAALADDYDEDSKLAINAKAAINFLNPEDVSIQYSFNHIRDYALENLELSYRLHYGEIASNDHRYPSGLFYHLRQNFGGFKKYTSFYYLVSSMEAFFDIFKKQYNTKYFADYYKSADYSTNYYNFDKYSKYYKQYYYSKDSEYYQKFYGQKKDYYNDKEPFKFTAPRIAKLLNIDAEEAEQLEGQLLFKLFNGYFFTAFDNQTIENLPHKMRHLFENLEDGYAFDVTKFYQQQDVVLAWPLATGFPFIYTLKAPTVFKFEVDASAKTHPQVYKMPAGHPETENDDFFYMPQSINGSVDVNLLYHRMVDAKVGFVTPFDHQRYIAGYQKKLHGYLPFNVELGLDFVKDEYEFEFKFLEPKDDHLLFHMSSWPYTGYKDITDMRPIAENPNAKIVHDDNQSTKTMEHTFGQDMTGVALRFHAKYDFDLINFQQFWSLVQKNDFVSAVNYPFAYQPYEYHQFNLFYDSQRTHAKSFKFYAYQKFGAPSFEETGPKHPANRHSYSGNYYESNYAQPFVYSPGSQRRYEQFFRNAASGIRNSFVRYYDFGFEFYAPQYKSEFTFTTAFADSPVDKTSRQLYYFYASPMFPSQSYFKDIPFSGKQFQFCATATSEFPRVPYLKFSDFDKYYGDASQYFDFLYGESCQGGAHIAVKGKQKQTGKYREYLRFSDVAKACKEQMANGYYQFEECQQAIDQAYYYDFYDYAIEYKDVGSVAKNLTNKFYNYFQYAFYPYFESNFFYHGKSNYIKAEFEFAPYGDYYNASFFGPSYAFQVQNYPVFNDYSTYFPYFFKYTFFPRYQPYYMHRLPAHKPRNRPYYELSNYEQFAVFDRKPQYPSCSFSNDYFYTFDNKKYFYDMGECWHAVMYTVKPDYDFYAQQSHFYNSDFEYKYKNGFEEYEQFAALARRGSDNQLYFKFLFGDNYIEVFPNNGGIPFVKYNGRPYDISKSNIAHFEYKEGYPSFPFFYAFAYPNKDLEVSFFGGKLKFATDGYRARFFSDYSFYNNFVGLCGTNNGEYFDEFVTPDQCYMRKPEFFAASYAITGQNCTGPAKAFNYAYQQKAKQECVKREVYYGDIIYNQEYYHPRYRYYNHNVEESSSSSSSSSSDSSSSSSSSESSSRSRSGSSSSSSSSEEQKEFHPHKQEHSMKECPVQHQHQFFEQGDRTCFSLRPLPVCHSKCVATEKISKYFDVHCFEKDSTQAKKYKSDIGRGYTPDFKSFAPHKTYKFNYPKSCVYKAY", "function": "Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. May supply aromatic amino acids to the cuticle of rapidly developing embryos.", "AFDB_id": "AF-Q16927-F1-model_v4" }, { "swissprot_id": "O49006", "sequence": "MAPSMKEIFSKDNFKKNKKLVLLSAAVALLFVAAVAGISAGASKANEKRTLSPSSHAVLRSSCSSTRYPELCISAVVTAGGVELTSQKDVIEASVNLTITAVEHNYFTVKKLIKKRKGLTPREKTALHDCLETIDETLDELHETVEDLHLYPTKKTLREHAGDLKTLISSAITNQETCLDGFSHDDADKQVRKALLKGQIHVEHMCSNALAMIKNMTDTDIANFEQKAKITSNNRKLKEENQETTVAVDIAGAGELDSEGWPTWLSAGDRRLLQGSGVKADATVAADGSGTFKTVAAAVAAAPENSNKRYVIHIKAGVYRENVEVAKKKKNIMFMGDGRTRTIITGSRNVVDGSTTFHSATVAAVGERFLARDITFQNTAGPSKHQAVALRVGSDFSAFYNCDMLAYQDTLYVHSNRQFFVKCLIAGTVDFIFGNAAVVLQDCDIHARRPNSGQKNMVTAQGRTDPNQNTGIVIQKCRIGATSDLQSVKGSFPTYLGRPWKEYSQTVIMQSAISDVIRPEGWSEWTGTFALNTLTYREYSNTGAGAGTANRVKWRGFKVITAAAEAQKYTAGQFIGGGGWLSSTGFPFSLGL", "function": "Acts in the modification of cell walls via demethylesterification of cell wall pectin.", "AFDB_id": "AF-O49006-F1-model_v4" }, { "swissprot_id": "Q5T2D3", "sequence": "MSRKQAAKSRPGSGSRKAEAERKRDERAARRALAKERRNRPESGGGGGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIKQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTEKSSVRELHIAYRYGEHYDSVRRINDNSEAPAHLQTDFQMLHQDESNKREKIKTKGMDSEDDLRDEVEDAVQKVCNATGCSDFNLIVQNLEAENYNIESAIIAVLRMNQGKRNNAEENLEPSGRVLKQCGPLWEEGGSGARIFGNQGLNEGRTENNKAQASPSEENKANKNQLAKVTNKQRREQQWMEKKKRQEERHRHKALESRGSHRDNNRSEAEANTQVTLVKTFAALNI", "function": "Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.", "AFDB_id": "AF-Q5T2D3-F1-model_v4" }, { "swissprot_id": "Q9FQ04", "sequence": "MGVPAFYRWLADRYPKSISDVVEEEPTDGGRGDLIPVDITRPNPNGFEFDNLYLDMNGIIHPCFHPEGKPAPATYDDVFKSMFEYIDHLFTLVRPRKILYLAIDGVAPRAKMNQQRSRRFRAAKDAAEAEAEEERLRKDFEMEGQILSAKEKAETCDSNVITPGTPFMAILSVALQYYIQSRLNHNPGWRYVKVILSDSNVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIMLSLATHEVHFSILREVITYPGQQEKCFVCGQTGHFASDCPGKSGSNNAAADIPIHKKKYQFLNIWVLREYLQYELAIPDPPFMINFERIIDDFVFLCFFVGNDFLPHMPTLEIREGAINLLMHVYRKEFTAMGGYLTDSGEVLLDRVEHFIQAVAVNEDKIFQKRTRIKQSMDNNEEMKQRSRRDPSEVPPEPIDDKIKLGEPGYKERYYAEKFSTTNPEETEQIKQDMVLKYVEGLCWVCRYYYQGVCSWQWFYPYHYAPFASDLKNLPDLEITFFIGEPFKPFDQLMGTLPAASSNALPGEYRKLMTDPSSPILKFYPADFELDMNGKRFAWQGIAKLPFIEEKLLLAATRKLEETLTVEEQQRNSVMLDLLYVHPAHPLGQRILQYYHFYQHMPPHECLPWMIDPNSSQGMNGFLWFSERNGFQTRVDSPVNGLPCIEQNRALNVTYLCPAKHSHISEPPRGAIIPDKILTSVDIKPFPPLWHEDNSNRRRQARDRPQVVGAIAGPSLGEAAHRLIKNTLNMKSSTGAASGLIDPNGYYRNVPGNYSYGGVNRPRAPGPSPYRKAYDDDSSYYYGKYNNSTQGTFNNGPRYPYPSNGSQDYNRNYNSKIVAEQHNRGGLGAGMSGLSIEDNGRSKQLYSSYTEAANANLNPLPSPPTQWIGTQPGGNFVGGYYRDGVGYSETNGKSVKKVIYQAKTQPSHRGANL", "function": "Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA target cleavage products that lack a 5'-cap structure. Antagonizes the negative feedback regulation on EIN3 by promoting EBF1 and EBF2 mRNA decay, which consequently allows the accumulation of EIN3 protein to trigger the ethylene response.", "AFDB_id": "AF-Q9FQ04-F1-model_v4" }, { "swissprot_id": "Q3YL95", "sequence": "MKKKLFALLKYIIFFPMLCTVLGLLGIPIGLIVNFLRTGSFDFNLKDEIDVVLFTLKIGIPIGFILGLGLWGLSILDRK", "function": "Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against CdiA from the same strain, its cognate toxin protein. Growth inhibition is reversible upon induction of this protein, occurring about 2.5 hours after induction, and requires an energy source. Does not protect against non-cognate CdiA from E.coli strain 563 / UPEC, D.dadantii strain 3937 or Y.pestis strain CO92.", "AFDB_id": "AF-Q3YL95-F1-model_v4" }, { "swissprot_id": "Q00224", "sequence": "MLMDVFSSFDAHSYNLIWLSMPLWLLSSMVPMTVLFSDVHSKSGSTSSFRSLVLSFTYSMIRLNGKGLKLSGFPLVMSGLFMMILMLNLSGNFPFFFPVSGQFVFGFSFALSIWTCLVLSSLLCSFEQGLMSLVPTGCPLILVPFMVVVELISGMLRPLTLVLRLTLNLGAGKVILTMCSSELVVGWLNSSSLITGVGGIKGLLMGGGVFGAAEVAIACIQCYIFCVLLCLYTEDHSS", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.", "AFDB_id": "AF-Q00224-F1-model_v4" }, { "swissprot_id": "Q58192", "sequence": "MVWLMEALKTKENETTKEKKLTTKVEKSEKKEENVREEEIVCPICGSKEVVKDYERAEIVCAKCGCVIKEKLFDIGPEWRAFDHEQKIKRCRVGAPMTYSVDYNEPIIIKENGEIKVVKIGELIDKIIENSENIRREGILEIAKCKGIEVIAFNSNYKFKFMPVSEVSRHPVSEMFEIVVEGNKKVRVTRSHSVFTIRDNEVVPIRVDELKVGDILVLAKELPNIEEDIEIDKKFSKILGYIIAEGYYDDKKIVLSYDYNEKEFINETIDYFKSLNSDITIYSKDLNIQIEVKNKKIINLLKKLRVKNKRIPSIIFKSPYEIKKSFIDGIFNGKDAKVFVSKELAEDVIFLLLQIKENATINKKSINDIEVYEVRRITNIYTNRKLEKLINSDFIFLKIKEINKVEPTSGYAYDLTVPNAENFVAGFGGFVLHNTIHDKGLSTVIDWRNKDSYGKDLSANKRAQLYRLRKWQRRIRVSDAAERNLAFALSELDRITSKLGLPRHVRENAAIIYRGAVEKGLIRGRSIEGVVAAAIYAACRRCRVPRTLDEIAEASRVDRKEIGRTYRFLARELNIKLTPTNPIDYVPRFASELGLPGEVESKAIQILQQAAEKGLTSGRGPTGVAAAAIYIASVLLGCRRTQREVAEVAGVTEVTIRNRYKELTEHLDIDVTL", "function": "Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).", "AFDB_id": "AF-Q58192-F1-model_v4" }, { "swissprot_id": "Q03877", "sequence": "MSRRVFTSAALHLLVVMWMCCGPCEAAAASTGENSVNARQPQRFDLFVPQKTVLLPRGGGNSEKKWDSFASPSLVSAGGVIAAFAEGHLSSKNKDNKSTEPSSDAVAWYIDSAWEWSTLVGEVNKSTWQAHTVLGKVDGKERFDVVLRPTTTTKDNKVFLLAGSSVASNVNGSWSHGGLKLKLVVGDVRKPTDSEQSGRINWGEVQSPLNENSGAVQERKLTAFVASGGAGVLMEDGTIVFSLMARNEEEDVYSMIIYSKDDGSTWALSNSVSSAKCVNPRITEWEGSLLMIVDCEDEQKVYVSRDMGTTWTEAVGKLLGVWVNSGSGASQDSSLHVDALITATIEGRRVMLYTQRGNSLGENANPLYLWVTDNNRSFHVGPVGMDNAEKEELESALLYSDGKLHLLQRRVSGEGSVISLSRLTEELKEIESVLSTWAQKDIFFSSLSIPTAGLVAVLSDAAGDGRWNDEYLCLNATVKNAVKVKDGFQLTESNSRVLWSVNTRDNNLRHVFLSHDFTVVATVIIQNVPSGKTSLLTATLANTESNYTMGLSYTADNKWETIFKGDKKPTTESRPWEPKKEYQVALMLQGKKASVYIDGRSLGEGEALLTDEKSLEFVHFCFGACVQESSPTAAQKTKVTVTNVFLYNRPLNSTEMRAIKDRIPIPKRGPGSQVEGGTERRHIPRIEGVRANAPVGSGLLPLLLLLGLWVFAAL", "function": "Implicated in attachment and penetration of host cells, possibly via a neuraminidase activity.", "AFDB_id": "AF-Q03877-F1-model_v4" }, { "swissprot_id": "Q47HZ8", "sequence": "MSSTQEDQPNPDFEIDHPEAYSQYFLTAPREISFYLNLLVKRGSLLTAHIDDGKAFFLTTMIAVDDEKQAIFLDSAQADELNTAAKNAHRITLTAKLDRVKIQLRLPPLRHQLVDGQKMLVAAFPQAILRIQRREFFRLESSSAHPILCRIAMEAPEGTLKTFEWNVADISGGGLSLNAPTSLINDCQRDALFKNSRLDIPGEGVLLVNLRVRKTSEFSAENGQHYLRVGCEFVELPGSRLAMIERYIARIERERKARDSGLAN", "function": "Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.", "AFDB_id": "AF-Q47HZ8-F1-model_v4" }, { "swissprot_id": "Q00870", "sequence": "MMISSVLVAGVVAVSAALASKHPKQYSFKPEDAETIWNGDIPVLYDFGDSQSASYSGSWWTSSYITGTNGEQYLVISHYLDTPVFTYFRASTLNLETLDYNQFITLGNNTANSTTLDVKVGDNGIQSLTADNISQQRAYANDENVTFDITFDATSRVISNAGAGVFQFGPSITYEWGLPNCRTQGSVTDTGGKNITVDPAKSFTWYDRQWGTAAVTSGNWTWFQMHIPETSYKLSVWIIDNDVTNQFSRFATIRGDNDEFQVLPLEWKPIYDRTYQSTAADILYPLDWELDISGFGVFQLSSILDDQEIVGTTAIQTAYEGFVTFNGTVHNKKVQGYGLVEVVYSNWESL", "function": "Converts fungitoxic kievitone to the less toxic kievitone hydrate, and thereby protects the pathogenic fungus against this phytoalexin.", "AFDB_id": "AF-Q00870-F1-model_v4" }, { "swissprot_id": "Q6Z398", "sequence": "MSAAAAIASPIPAAIAVVQQQRRGRSRGGGSGAAAVRCSAVAPTSAIAPILADLRLRCAAPLPVLRRVADAMASGMRAGLADDGAGELKMIPSHVYSLPTGNETGLFYALDLGGTNFRVLRVQLGGKDKRIIDTEFEQVSIPREIMHGITEDLFDFIASGLSRFVATEGDKFHLPQGRKRELGFTFSFPVNQTSIDSGILIKWTKGFAVSGTAGKDVVACLNAAMERQGLDMRVSALVNDTVGTLAGARYWDDDVMVAVILGTGTNACYIQRTEAIPKLQHLKLETGNTIINTEWGAFSDGLPLTEFDREMDDESINPGEQIFEKTISGMYLGEIVRRVLVKMAEVSDLFGHSFPKKLAEPFVLRTPHLCAMQQDTSDNLGEVESILSDVIGVSQASLLARRVTVEVSDCIIRRGGRLAGAGIVGILEKMENDSRGHIFGRRTVVAMDGGLYEKYPQYRRYMKEAVAELLGPERSNRIAIEHTKDGSGIGAALLAAANSKYAAAQISTR", "function": "Fructose and glucose phosphorylating enzyme.", "AFDB_id": "AF-Q6Z398-F1-model_v4" }, { "swissprot_id": "B7SY83", "sequence": "MEVKEEKLMEEKQRLPEKTIPVFTVLKNGAILKNIFVVNSRDFSSPERNGSTVSDDDGEVEEILVVGRHPDCDILLTHPSISRFHLEIRSISSRQKLFVTDLSSVHGTWVRDLRIEPHGCVEVEEGDTIRIGGSTRIYRLHWIPLSRAYDLDNPFVSPLDASTVLEQEEENRMLEAENLEVAQHQSLENTTSGDEGVLHLDVTSEGTGSSVPSEDEDTYVTTREMSMPVASPSVLTLVRDSVETQKLQFNEDLQTSPKWDLDVIESVAEKLSGSFVRSTQQSGGDVEGLGCSELFDAAEADECDVRGDGGLHLNVISEKMESSVPNMIEAENLEVAQHQSLANTALGDDEDLHLDVTSEGTGSSVPSEDEDTYITTMEISVPLASPNVLTLARDSIKTQKLQSTQDFQTPTMWDLDVVEAAAEKPSSSCVLGKKLSGGYVEELGCFELFVAAEADKCDVRGDGSLHLNEISERMESSMSNKEDDPFLAAKETSSLPLSTDFINPETLWLVEDVQASPEFCTSSVKANAENPSSGCSPSTEQIDGCFETSGCSAFDLAAEVESLSLHQEVSEETEFVTKEVMGVSSEPLGKADIRSHEENGESEDSRQVIEVSAEPVAKADIQSHEENGETEGSRQVIEVSPKSFSEAEPTIEILTGEAQGIIGSEFPSELAVETESENLLHQKSIGETKNEIRSHEDYGETEDYGETECSWPDIAVSPSSVSPPEPTLEILTDEARGLLGSEFLSEVTVETEIENLLHQKSNVETKADILIHEDYGETEVSRQIITVSPNSFSKAEPTLETEDSRQQARGLVGSDSEFQSEVAMKTECENLLNQKRNGETKVSSRQASPVSDCLSTPKDRLSSINTDDIQSLCSSSQPPSESEVNPATDQDQESGIISETEKPKTELLIGSGRSEKYYSLSEIEGEENTDIGRLSRCPIPSALAAKTSEDTKLIEELSSSDSGSQENQTPETHAVRDDVLCDMDSSSTCNIWSRRGKAASVLKIRTNKSQGKQKQTGRQPKDKLHRKQALSDKSISLTIHHGAEILEPEIFTPDKENLTPSSHMLKRLQDIGDVKDSKSSLKLSGKSCSSLVHSSIAVLASEAFTEPEIFTPDKENLTPSSHMLKRLREFGDIKDTKGSSSKATRKPFFDIRMEENVMVEQEPEDLHSLGSKSKLKHEPLAPKKKAERAPFQPLLEKSSFQSQSYTEASSTASARNNISRGIRSSSNLSDAKSKMKWTIVLDTSSLLDKESRKPLQLLQGLKGTHLVVPRTVLRELNEVKRSRSFLFRRRTEIASSALDWIEECKVNSKWWIQVQSPTEETKAIAPTPPVTPQSNGSSAFPFSLHWNNYAPEIDSPTSEDQVLECALLYRNRNRDEKLVLLSNDVTLKIKAMAEGVICETPHEFYESLVNPFSERFMWTESTARGRTWSHLDNDVLRERYNDRACRRKSTYNRGESGAAAKGLKLILLHNSHYGHTH", "function": "Required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. Not involved in female meiosis.", "AFDB_id": "AF-B7SY83-F1-model_v4" }, { "swissprot_id": "Q8R689", "sequence": "MKKNEYFNEIEKIYKEMSSHFKERLKEFKNIWENGTNKDIHLELSFCILTPQSKALNAWQAITNLKKDDLIYNGKAEELVEFLNIVRFKNNKSKYLVELREKMMKDGEIITKDFFNTLPTVAEKREWIVKNIKGMSYKEASHFLRNVGFGENIAILDRHILRNLVKLEVIDELPKTLTPKLYLEIEEKMRDYCEFVKIPMDEMDLLLWYKEAGVIFK", "function": "Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).", "AFDB_id": "AF-Q8R689-F1-model_v4" }, { "swissprot_id": "O05508", "sequence": "MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEKEPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAADFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGGRVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQDGKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGFMPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRKMNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRIEFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVKKSGKWFKEVAEHSGF", "function": "Phospho-beta-D-glucosidase that seems to be involved in the degradation of glucomannan. Is also capable of hydrolyzing aryl-phospho-beta-D-glucosides, although very weakly, and plays only a minor role, if any, in the degradation of these substrates in vivo.", "AFDB_id": "AF-O05508-F1-model_v4" }, { "swissprot_id": "A0A090XBL6", "sequence": "FFQLAVFVVILFNINLLSASAGSKGSSAPQSSGDSVVAEFCDTNCTMKKDGKWTECNGDCFCVHVGNETVGRCMRLDGDYDYTSSKTTRRNKKTRNGLCRLDRNRTTVDYPERNTREP", "function": "Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13.", "AFDB_id": "AF-A0A090XBL6-F1-model_v4" }, { "swissprot_id": "B9KDV9", "sequence": "MSGFSLEKFNFVLLFPVLSLLFWAIVLLLLDAFKKLSRNFYIGASIIALFSTLCFLLIYNGFVLDNSHAFFDLFVSDNYAIFAQIVILVFSMLYLLMDKDEQKAEFFSLFLFMIASLILMISSTNLIVIFLALEGSSLALYTLIALRGTHNAISSSIKYFTLAAVGAGFFVFACAFVYLKTKSLDLDNLLHSEYISDPILLCAGVMFLVIVGVKLSIAPFHFWLKDVYYGVHTNFIAFISIVPKIAMIIVVLRIFSALGGGVKFEYIVALLAIFSMLAVSIVALIQKDVKKMLAYSSITHSSFILAVIVSSMSVSSQGDGTSYLLSIFALFVYWISFAFANYGIFLILSLFQKSSFESFSGLFDQRPVLSIMLAIFILCIAGIPPFGIFWGKILILASILNSGYYALVFAVALSSMIMLYAYLKILIYVFFKKAQIVESANLDVKQKIILCLCLIGSVSCVFLLL", "function": "NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.", "AFDB_id": "AF-B9KDV9-F1-model_v4" }, { "swissprot_id": "Q5RAL4", "sequence": "MKDRLQELKQRTKEIELSRDSHVSTTETEEQGVFLQQAVIYEREPVAERHLHEIQKLQESINNLADNVQKFGQQQKSLVASMRRFSLLKRESTVTKEVKIQAEYINRSLNDLVKEVKKSEVENGPSSVVTRILKSQHAAMFCHFQQIMFIYNDTIAAKQEKCKTFILRQLEVAGKEMSEEDVNDMLHQGKWEVFNESLLTEINITKAQLSEIEQRHKELVNLENQIKDLRDLFIQLSLLVEEQGESINNIEMTVNSTKEYVNNTKEKFGLAVKYKKRNPCRVLCCWCCPCCSSK", "function": "Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR).", "AFDB_id": "AF-Q5RAL4-F1-model_v4" }, { "swissprot_id": "Q9AV39", "sequence": "MLPYATAAEAEAALGRAMTAAESLWFRYSAGIPDYVLFWHNILFLFVVFTLAPLPVALLELRAPAAVGPFKLQPKVRLSREEFFRCYRDVMRLFFLVIGPLQLVSYPTVKMVGIHTGLPLPSLGEMAAQLLVYFLVEDYLNYWIHRLLHGEWGYEKIHRVHHEFTAPIGFAAPYAHWAEVLILGIPSFVGPALAPGHMITFWLWIVLRQMEAIETHSGFDFPFNLTKYIPFYGGAEYHDYHHYVGRQSQSNFASVFTYCDYLYGTDKGYRYHKAYQAKMKALGQTEGEKADSNGLSYAKLD", "function": "Aldehyde decarbonylase involved in the conversion of aldehydes to alkanes. Core component of a very-long-chain alkane synthesis complex.", "AFDB_id": "AF-Q9AV39-F1-model_v4" }, { "swissprot_id": "H8WEC1", "sequence": "MSERSVYMVLSPRFSVRAVSLAVAAVSASLSMPTSASMGNLGTSYGVMPVDVATAQSLSMFNEQVSATYYNPAALTKDPRGELTAGILHSEQELRSDNPNASGDIVSDSPSQHVLIGMKTNLGSLTRFGHPIYLGFIAGVEKYGKEMLAFSSETSESGQFLQYGKEPLFLNIGGATPIWRGISAGASVRVTLEATANLDAVSTLGGETSRERLAVNAEPSLKTILGTNIDLGSTFCPESDCFLNGWETALTYRTKSSASTTVDSNIIVTQTIPDPGLSLAVTTIDSFQPETIAIGTQYSGDGWRIGGSIEQQNWSELEDEFSGDSIKDQGSVASGNRIGFDDILIPRLGAEYQLNKNFAVRGGVAYEESPLKTTRNPELNYLDTDKLVVGLGISATYDRTRLLAYPVRLDLGYQYQQLQERDFTVVDYDGDETSVTADGDIHVFSGSITLKF", "function": "Required for growth on alkanes. Probably involved in the uptake of micelle-solubilized alkanes.", "AFDB_id": "AF-H8WEC1-F1-model_v4" }, { "swissprot_id": "Q966X9", "sequence": "MSHKVTKAHNGATLTVAVGELVEIQLPSNPTTGFAWYFEGGTKESPNESMFTVENKYFPPDSKLLGAGGTEHFHVTVKAAGTHAVNLTYMRPWTGPSHDSERFTVYLKAN", "function": "Tight-binding and reversible inhibitor of papain-like cysteine proteases.", "AFDB_id": "AF-Q966X9-F1-model_v4" }, { "swissprot_id": "B0ZT46", "sequence": "MSGRRRRLTESVSTRVGSYHVADAVALQREGAAMVVGIDILLTWNGSLPFSLGDLRFLHCVRSERRSCGKSLPGMNSSRVNMAETSGISAFTQFWGCIRLDGSCEVTRRPAMDLHGHHYREAYLQPAIMDGPCTGASSSARGRDGKKALIHRLLAALCPVRCPAKISGSSVRPMLAASRISGPVRSFIASCRRQDEQMNGRSQMRDCARRAFLPLRVSDARSEWICFIVAIW", "function": "Oxidoreductase; part of the gene cluster that mediates the biosynthesis of elsinochromes, pigments consisting of at least four interconvertible tautomers (A, B, C and D) that have a core phenolic quinone to which various side chains are attached and which play an important role in fungal pathogenesis. The non-reducing polyketide synthase PKS1 was proposed to iteratively catalyze decarboxylation between acetyl-CoA and malonyl-CoA subunits for polyketide chain elongation. The released polyketide undergoes cyclization to form an aromatic ring, and proceeds via serial modification steps to produce the heptaketide back- bone of elsinochrome. As elsinochrome has a symmetrical structure, two identical heptaketides are fused to form a core 1,2-dihydrobenzo-perylene ring structure, which can then be successively modified to produce the various derivatives of elsinochrome. Some of these reactions may be cooperatively carried out, at least in part, by the products of RDT1, OXR1 and PKS1. PRF1, embedded within the elsinochrome cluster possibly functions to stabilize some of the biosynthetic enzymes required for elsinochrome production. As prefoldin is a hexamer containing 2 a and 4 b subunits, additional prefoldin subunits, whose coding genes may not immediately link to the elsinochrome biosynthetic gene cluster, are required to fulfill the chaperone function. In addition, no methyltransferase-coding gene exists within the biosynthetic gene cluster, even though elsinochrome has four methyl groups at positions C3, C7, C8 and C12. Apparently, the identified gene cluster does not contain the entire entourage of genes responsible for elsinochrome biosynthesis. Once elsinochrome is synthesized, it must be exported outside the fungal cells, which is probably accomplished by the ECT1 transporter, to avoid toxicity.", "AFDB_id": "AF-B0ZT46-F1-model_v4" }, { "swissprot_id": "Q9JHX6", "sequence": "MTDTPKEGKLTRFLDFTQLIDLASECVGGKVLFATDDFFGPAENLIKSDSPTFKEHEYTEFGKWVDGWETRRKRIPGHDWCVIQLGIQGIIRGIDVDISYFSGNHAPRMSIQAANLSEEDTMSNIPPRGVRMGTAATPEEFEAVTELKSHSWDYLVPMSELKLGDPDSSHNYYFVNSQQRWTHIRLNIFPDGGVARLRVYGTGQRDWAALDSTEPVDLVAIAFGGVCVGFSNAHFGHPNNMIGVGEPKSIADGWETARRLDRPPVLEASENGLLLVPGCEWAVFRLAHPGVITQIEIDTKYFKGNCPNSCKVDGCILTTLEEEDMIRHNWNLPAHKWKSLLPVTKLIPNQNHLLDSLTLELQDVITHAMITIAPDGGVSRLRLKGFPSSICLLRPLREKPLLRFSLKTGFRANL", "function": "The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.", "AFDB_id": "AF-Q9JHX6-F1-model_v4" }, { "swissprot_id": "Q460N3", "sequence": "MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSRSMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGPLSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSWQIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSPLQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMKIGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHRDFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITVADNIIDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTCNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA", "function": "Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Acts as a negative regulator of transcription.", "AFDB_id": "AF-Q460N3-F1-model_v4" }, { "swissprot_id": "P71785", "sequence": "MRIVNAADPFSINDLGCGYGALLDYLDARGFKTDYTGIDVSPEMVRAAALRFEGRANADFICAARIDREADYSVASGIFNVRLKSLDTEWCAHIEATLDMLNAASRRGFSFNCLTSYSDASKMRDDLYYADPCALFDLCKRRYSKSVALLHDYGLYEFTILVRKAS", "function": "Probably plays a role in host phagosome maturation arrest, as well as a role in the synthesis of acyltrehalose-containing glycolipids.", "AFDB_id": "AF-P71785-F1-model_v4" }, { "swissprot_id": "P19072", "sequence": "MTHLKGFDLLALGFMTFALFLGAGNIIFPPSAGMAAGEHVWSAAFGFLLTGVGLPLLTVVALARVGGGIGRLTQPIGRRAGVAFAIAVYLAIGPLFATPRTAVVSFEMGVAPFTGDGGVPLLIYTVAYFSVVLFLVLNPGRLVDRVGKVITPVLLSALLVLGGAAIFAPAGEIGSSSGEYQSAPLVQGFLQGYLTMDTLGALVFGIVIATAIRDRGISDSRLVTRYSMIAGVIAATGLSLVYLALFYLGATSQGIAGDAQNGVQILTAYVQQTFGVSGSLLLAVVITLACLTTAVGLITACGEFFSDLLPVSYKTVVIVFSLFSLLVANQGLTQLISLSVPVLVGLYPLAIVLIALSLFDRLWVSAPRVFVPVMIVALLFGIVDGLGAAKLNGWVPDVFAKLPLADQSLGWLLPVSIALVLAVVCDRLLGKPREAVA", "function": "Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions.", "AFDB_id": "AF-P19072-F1-model_v4" }, { "swissprot_id": "Q9V7G5", "sequence": "MFVEKVLERTTNLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLVTDKDLMRRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTEINIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKERDHPLIAH", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.", "AFDB_id": "AF-Q9V7G5-F1-model_v4" }, { "swissprot_id": "P26449", "sequence": "MQIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSDDTFKTNAAIDQTIELNASSIYIIFDYEN", "function": "Required for cell cycle arrest in response to loss of microtubule function. Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.", "AFDB_id": "AF-P26449-F1-model_v4" }, { "swissprot_id": "Q9ZVC9", "sequence": "MDVHLVEENVSMGNHEIGDEGDVEPSDCSGQNNMDNSLGVQDEIGIAEPCVGMEFNSEKEAKSFYDEYSRQLGFTSKLLPRTDGSVSVREFVCSSSSKRSKRRLSESCDAMVRIELQGHEKWVVTKFVKEHTHGLASSNMLHCLRPRRHFANSEKSSYQEGVNVPSGMMYVSMDANSRGARNASMATNTKRTIGRDAHNLLEYFKRMQAENPGFFYAVQLDEDNQMSNVFWADSRSRVAYTHFGDTVTLDTRYRCNQFRVPFAPFTGVNHHGQAILFGCALILDESDTSFIWLFKTFLTAMRDQPPVSLVTDQDRAIQIAAGQVFPGARHCINKWDVLREGQEKLAHVCLAYPSFQVELYNCINFTETIEEFESSWSSVIDKYDLGRHEWLNSLYNARAQWVPVYFRDSFFAAVFPSQGYSGSFFDGYVNQQTTLPMFFRLYERAMESWFEMEIEADLDTVNTPPVLKTPSPMENQAANLFTRKIFGKFQEELVETFAHTANRIEDDGTTSTFRVANFENDNKAYIVTFCYPEMRANCSCQMFEHSGILCRHVLTVFTVTNILTLPPHYILRRWTRNAKSMVELDEHVSENGHDSSIHRYNHLCREAIKYAEEGAITAEAYNIALGQLREGGKKVSVVRKRIGRAAPPSSHGGGIGSGDKTSLSAADTTPLLWPRQDEMIRRFNLNDGGARAQSVSDLNLPRMAPVSLHRDDTAPENMVALPCLKSLTWGMESKNTMPGGRVAVINLKLHDYRKFPSADMDVKFQLSSVTLEPMLRSMAYISEQLSSPANRVAVINLKLQDTETTTGESEVKFQVSRDTLGAMLRSMAYIREQLSIVGELQTESQAKKQRK", "function": "Putative transcription activator involved in regulating light control of development.", "AFDB_id": "AF-Q9ZVC9-F1-model_v4" }, { "swissprot_id": "P36881", "sequence": "MLGWVITCHDDRAQEILDALEKKHGALLQCRAVNFWRGLSSNMLSRMMCDALHEADSGEGVIFLTDIAGAPPYRVASLLSHKHSRCEVISGVTLPLIEQMMACRETMTSSEFRERIVELGAPEVSSLWHQQQKNPPFVLKHNLYEY", "function": "The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.", "AFDB_id": "AF-P36881-F1-model_v4" }, { "swissprot_id": "A4X3Q0", "sequence": "MQHNLIAFLSDVGSADEAHALCKGVMYGVAPAATIVDITHDVAPFDVREGALFLADVPHSFPAHTVICAYVYPETGTATHTIAVRNEKGQLLVGPNNGLLSFALDASPAVECHEVLSPDVMNQPVTPTWYGKDIVAACAAHLAAGTDLAAVGPRIDPKQIVRLPYASASEVEGGIRGEVVRIDRAFGNVWTNIPTHLIGSMLQDGERLEVKIEALSDTVLELPFCKTFGEVDEGQPLLYLNSRGRLALGLNQSNFIEKWPVVPGDSITVSPRVPDSNLGPVLG", "function": "Involved in the biosynthesis of the proteosome inhibitor salinosporamide A (SalA). Catalyzes the halogenation of S-adenosyl-L-methionine (SAM) with chloride to generate 5'-chloro-5'-deoxyadenosine (5'-CIDA) and L-methionine. It can also use bromide and iodide, producing halogenated 5'-deoxyadenosine (5'-XDA) and L-methionine, however no halogenase activity is detected in the presence of fluoride.", "AFDB_id": "AF-A4X3Q0-F1-model_v4" }, { "swissprot_id": "P44652", "sequence": "MKVRLKSKKKMKKPALNPERRKFLKEATRTAGGLAGVGILLGLQQNQSLAREGVPLRPPFALQDAKAFSAACIRCGQCVQACPYDMLHLASLLSPVEAGTPYFIARDKPCEMCPDIPCAKACPSGALDRQATDINESRMGLSVLLDHETCLNYQGLRCDVCYRVCPLIDKAITLETQHNPRSDKHALFIPTVHSDACTGCGKCEQACVLEEAAIKILPMDLAKGMLGKHYRLGWEEKAKAGHSLAPKDMISLPTRTPEGTTVIPEPAEPVLAPILGSGK", "function": "Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.", "AFDB_id": "AF-P44652-F1-model_v4" }, { "swissprot_id": "O04035", "sequence": "MVNEKKMLPKRIILMRHGESAGNIDAGAYATTPDHKIPLTEEGRAQAREAGKKMRALISTQSGGACGENWRVYFYVSPYERTRTTLREVGKGFSRKRVIGVREECRIREQDFGNFQVEERMRVVKETRERFGRFFYRFPEGESAADVYDRVSSFLESMWRDVDMNRHQVDPSSELNLVIVSHGLTSRVFLTKWFKWTVAEFERLNNFGNCEFRVMELGASGEYTFAIHHSEEEMLDWGMSKDMIDDQKDRVDGCRVTTSNDSCSLHLNEYFDLLDVTDDEE", "function": "May play a role in carbohydrates metabolism.", "AFDB_id": "AF-O04035-F1-model_v4" }, { "swissprot_id": "Q92356", "sequence": "MSEPYDPYIPAEPSAAVRSGNAAASSTPNMKTAAIQQQIDDTVGIMRENISKVSERGERLDSLQDKTDNLAVSAQGFRRGANRVRKKMWWKDMRMRLCIIIGIIILLVVIIVPIATKFHGK", "function": "Involved in membrane trafficking during cytokinesis and cell elongation.", "AFDB_id": "AF-Q92356-F1-model_v4" }, { "swissprot_id": "D4GP36", "sequence": "MATHDNTEHVSDATDEAVGWESKLRYFLNSDFVRSAPYWGIPFVLMSIAVYGGTGYNFAISFTDYEGLGTPDYSTLDLEMYAQALSSDAFIAAAQNNLVLLVGFTTICLVLGLFLAILLDHGIRFSEKFQTVYLLPMSLSFVVTAQLWLWMFNVESGILNLVVTTLGFNPVDWLGNPSIALGAVILALIWQFSGYTMVVYLAGLQSIPDDQFEAARVDGASITRTYLRIIVPQLKEASVSAAVVLMVFALKAFTFLYALVGRYRPPNGTDILATLMVRRAFKFGEWAYSAAIATMLLIMALGVIGPYLYYQYKQGGL", "function": "Part of the ABC transporter complex XacGHIJK involved in the uptake of xylose and arabinose. Responsible for the translocation of the substrate across the membrane (Probable).", "AFDB_id": "AF-D4GP36-F1-model_v4" }, { "swissprot_id": "P29340", "sequence": "MPNFWILENRRSYTSDTCMSRIVKEYKVILKTLASDDPIANPYRGIIESLNPIDETDLSKWEAIISGPSDTPYENHQFRILIEVPSSYPMNPPKISFMQNNILHCNVKSATGEICLNILKPEEWTPVWDLLHCVHAVWRLLREPVCDSPLDVDIGNIIRCGDMSAYQGIVKYFLAERERINNH", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Essential for peroxisome biogenesis. Required for UBC4-independent ubiquitination of PEX5.", "AFDB_id": "AF-P29340-F1-model_v4" }, { "swissprot_id": "P81065", "sequence": "MKLYYKVGACSLAPHIILSEAGLPYELEAVDLKAKKTADGGDYFAVNPRGAVPALEVKPGTVITQNAAILQYIGDHSDVAAFKPAYGSIERARLQEALGFCSDLHAAFSGLFAPNLSEEARAGVIANINRRLGQLEAMLSDKNAYWLGDDFTQPDAYASVIIGWGVGQKLDLSAYPKALKLRERVLARPNVQKAFKEEGLN", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.", "AFDB_id": "AF-P81065-F1-model_v4" }, { "swissprot_id": "P04840", "sequence": "MSPPVYSDISRNINDLLNKDFYHATPAAFDVQTTTANGIKFSLKAKQPVKDGPLSTNVEAKLNDKQTGLGLTQGWSNTNNLQTKLEFANLTPGLKNELITSLTPGVAKSAVLNTTFTQPFFTARGAFDLCLKSPTFVGDLTMAHEGIVGGAEFGYDISAGSISRYAMALSYFAKDYSLGATLNNEQITTVDFFQNVNAFLQVGAKATMNCKLPNSNVNIEFATRYLPDASSQVKAKVSDSGIVTLAYKQLLRPGVTLGVGSSFDALKLSEPVHKLGWSLSFDA", "function": "Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Is the major permeability factor of the mitochondrial outer membrane.", "AFDB_id": "AF-P04840-F1-model_v4" }, { "swissprot_id": "S0E9M0", "sequence": "MSIFNMITSYAGSQLLPFYIAIFVFTLVPWAIRFSWLELRKGSVVPLANPPDSLFGTGKTRRSFVKLSREILAKARSLFPNEPFRLITDWDFADEIRNDPRLSFSKAAMQDNHAGIPGFETVALVGREDQLIQKVARKQLTKHLYIIARISSRIYLGDQLCRNEAWLKITKTYTTNFYTASTNLRMFPRSIRPLAHWFLPECRKLRQERKDAIGIITPLIERRRELRRAAIAAGQPLPVFHDAIDWSEQEAEAAGTGASFDPVIFQLTLSLLAIHTTYDLLQQTMIDLGRHPEYIEPLRQEVVQLLREEGWKKTTLFKMKLLDSAIKESQRMKPGSIVTMRRYVTEDITLSSGLTLKKGTRLNVDNRRLDDPKIYDNPEVYNPYRFYDMRSEAGKDHGAQLVSTGSNHMGFGHGQHSCPGRFFAANEIKVALCHILVKYDWKLCPDTETKPDTRGMIAKSSPVTDILIKRRESVELDLEAI", "function": "Gibberellin 20-oxidase; part of the gene cluster that mediates the biosynthesis of gibberellins (GAs), diterpenoids that may provide a selective advantage during infection of the preferred host plant, rice. Gibberellins (GAs) are diterpenoids and are synthesized via the mevalonate pathway. Biosynthesis of the major metabolite GA3 (gibberellic acid) from geranylgeranyl diphosphate (GGPP) requires 13 steps. The GGPP produced by the geranylgeranyl diphosphate synthase GGS2 is converted to ent-kaurene via ent-copalyldiphosphate in a two-step cyclization reaction performed by the bifunctional ent-copalyl diphosphate synthase/ent-kaurene synthase enzyme (CPS/KS). Ent-Kaurene is metabolized to GAs by a series of oxidation reactions catalyzed by cytochrome P450 monooxygenases. Cytochrome P450 monooxygenase P450-4 is an ent-kaurene oxidase that catalyzes the three oxidation steps between ent-kaurene and ent-kaurenoic acid. The highly multifunctional cytochrome P450 monooxygenase P450-1 then catalyzes four steps involving oxidation at two carbon atoms, in the main pathway from ent-kaurenoic acid to GA14 via GA12-aldehyde as well as producing kaurenolides and fujenoic acids as by-products. The cytochrome P450 monooxygenase P450-2 then converts GA14 to GA4 by removal of C-20. GA4 is further converted to GA7 by the GA4 desaturase DES via 1,2-desaturation before cytochrome P450 monooxygenase P450-3, a 13-hydroxylase, hydroxylates GA7 to GA3, the final product of the GA-biosynthetic pathway.", "AFDB_id": "AF-S0E9M0-F1-model_v4" }, { "swissprot_id": "Q96NW7", "sequence": "MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV", "function": "Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.", "AFDB_id": "AF-Q96NW7-F1-model_v4" }, { "swissprot_id": "A6VX99", "sequence": "MKVGVMDSGAGGLTILNAIHQKHPYLDLVYLADDAFAPYGSKSITQLQDRLVKVGRFFENEKVCAIVVACNTATVAAIDALRASTSLPIIGVEPAVKPAFRLSKKRRVAVLATPVTAESPRLNQLIDLWKEDSHVSIMSSLTLAFDIDAWPETEEKVKQTIEQLSQEMLAQNIDTLVLACTHYPLVKHLFEQILGDECEIIEPSEGVTAQLIRRLTESYPNDMSQLLDAVSTRQDSSQNQGSIELCSSLGFKNMQRLNSWVVSSSAIKGCRHVLI", "function": "Provides the (R)-glutamate required for cell wall biosynthesis.", "AFDB_id": "AF-A6VX99-F1-model_v4" }, { "swissprot_id": "Q8N5H7", "sequence": "MTEGTKKTSKKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLEPDTFEATQDDMVTVPKSPPAYARSSDMYSHMGTMPRPSIKKAQNSQAARQAQEAGPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTPAMEPNPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL", "function": "May be involved in the BCAR1/CAS-mediated JNK activation pathway.", "AFDB_id": "AF-Q8N5H7-F1-model_v4" }, { "swissprot_id": "P07102", "sequence": "MKAILIPFLSLLIPLTPQSAFAQSEPELKLESVVIVSRHGVRAPTKATQLMQDVTPDAWPTWPVKLGWLTPRGGELIAYLGHYQRQRLVADGLLAKKGCPQSGQVAIIADVDERTRKTGEAFAAGLAPDCAITVHTQADTSSPDPLFNPLKTGVCQLDNANVTDAILSRAGGSIADFTGHRQTAFRELERVLNFPQSNLCLKREKQDESCSLTQALPSELKVSADNVSLTGAVSLASMLTEIFLLQQAQGMPEPGWGRITDSHQWNTLLSLHNAQFYLLQRTPEVARSRATPLLDLIKTALTPHPPQKQAYGVTLPTSVLFIAGHDTNLANLGGALELNWTLPGQPDNTPPGGELVFERWRRLSDNSQWIQVSLVFQTLQQMRDKTPLSLNTPPGEVKLTLAGCEERNAQGMCSLAGFTQIVNEARIPACSL", "function": "Catalyzes the hydrolysis of phytate (or myo-inositol hexakisphosphate, an indigestible organic form of phosphorus that is found in many plant tissues) to myo-inositol and inorganic phosphate. Dephosphorylates phytate in a stereospecific way by sequential removal of phosphate groups to produce myo-inositol 2-monophosphate. Also shows phosphoanhydride phosphatase activity and hydrolyzes the distal phosphoryl residues of GTP, the 5'-beta-phosphoryl residue of the regulatory nucleotide ppGpp and tripolyphosphates. Does not split most phosphomonoesters with the exception of the synthetic substrate p-nitrophenyl phosphate (pNPP), 2,3-bisphosphoglycerate and fructose 1,6-bisphosphate.", "AFDB_id": "AF-P07102-F1-model_v4" }, { "swissprot_id": "Q9P7Y0", "sequence": "MAATMAAQSLLSIPVEYRSQVWCRANLPYPPAPQLPIPAVVDILTKASQALPQISFSWTLIDQPPDGSLFLVWQAPTLPSPPDGMHFMSNERFFNMDVAGKVLEIHEAKHGFYPLSETRTMHVRCRYRLLGVGFDNFWLVHYFQGSETDSIPANISVAKPPHLRRYPLPDVKTSPFLLQEPKKHIPEGTALSQRETLPNMGSAQMKSQSRTPSFSNVTTSPVPPINSNATAQTAEGHMGATNMTVDNMNKPSIPPNGNTSILMQEDLEIEKGDVMDKLSPQQICTARFIKHAEWMSQVLLTLQSVKDIEPPALWQEPNSMEELGKELKDNKEQLVKQDQKYQSLQGDLSYTDSMSNLLKEFSNIKSAEECDVLQKKIEEFAEAKIVPLSHVTERS", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.", "AFDB_id": "AF-Q9P7Y0-F1-model_v4" }, { "swissprot_id": "O35016", "sequence": "MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGGWHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGFKNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL", "function": "Dephosphorylates the phosphotyrosine-containing proteins. Involved in ethanol stress resistance.", "AFDB_id": "AF-O35016-F1-model_v4" }, { "swissprot_id": "Q94KJ7", "sequence": "MAQIPSLENAPLNLKSIRDKSERELVNLLKDVRGTKCLVIDPKLSGSVSLIIPTSKLKELGLELRHLTAEPVQTECTKVVYLVRSQLSFMKFIASHIQNDIAKAIQRDYYVYFVPRRSVACEKILEQEKVHNLVTVKEFPLYMVPLDEDVISFELELSEKDCLVDGDVSSLWHIAKAIHELEFSFGVISKMRAKGKASVRVADILNRMQVEEPVNSNDVGRPEVDTLILLDREVDMVTPMCSQLTYEGLIDEILHISNGAVEVDSSVMGAQQEGKKMKVPLNSSDKLFKETRDLNFEVVVQVLRQKAMTMKEDYTEINSTQTVSELKDFVKKLNSLPEMTRHIHLAQHLTTFTSKQSFNSQLDMEQTLVEAENYDICYEYIEEMIHKQEPLTNVLRLLVLFSVTNSGLPKKQFDYIRMELLHSYGFEHVVTLNNLEKAGLLKKQEFKSNWLTVKRTLKLIVEDTDTSRPNDIAYVYSGYAPLSIRLIQQAIHSGWRPMEDILKLLPGPHLETKRSGFPSSPSVDSLHGASNGVADGRRSIVLVVFIGGVTFAEISALRYLASKEGMAYDLIVATTKIVNGATLIETFMEKLG", "function": "Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.", "AFDB_id": "AF-Q94KJ7-F1-model_v4" }, { "swissprot_id": "Q3U1C6", "sequence": "MGLGLVDCHCHLSASDFDNDLDDVLEKARKANVMALVAVAEHAGEFERIMQLSERYNGFVLPCLGVHPVQELSPEKPRSVTLKDLDVALPIIEKYKDRLLAIGEVGLDFTPRYAGTDEEKEEQRQVLIRQVQLAKRLNVPLNVHSRSAGRPTISLLREQGAEQVLLHAFDGRPSVAMEGVRAGYYFSIPPSIVRSGQKQKLVKQLPLSSICLETDSPALGPEKLTRNEPCNISIAAEFIAQVKGISVEEVREVTTRNAFRLFPKLQSLLQKELQSHPLQAKSAQGSAGESKGLL", "function": "Putative deoxyribonuclease.", "AFDB_id": "AF-Q3U1C6-F1-model_v4" }, { "swissprot_id": "Q872I5", "sequence": "MDHFSTVLQRPPHFDEDGTEGRGDRGNGAGPGPAPPPPPPRGGLRDILNPVSSNSAVQSQAAAAAPPPPPAVASSSLHGIAASVPPPSSTNSMRATPHSSSSFNLRSPTREPSEYRHPLSSLATPAPFAASPPTSIANANNTNNNNALGAAGSLSSQPPPPPPTGPRSILNPPTPSQQHQQQHHHPNPFVAASAPSLPPPPSSLQAPPAITPIAGLSAPAPASGSLPLSAGGIGNSITVSSSSQPPARASQLHAPSAYYSPAESFRDRDSSVREKSSTGGSFYDPTAEASNGISGSSPRKDRDRDRDHRGTTRESQRRSVSGHSDTGSSWRNATQTSASNKTRDPYNYSPSSADYYNTRKKENYPVDNTTSSSIAAPSNFTVATRSPVAALSHPASIAAPASVGSLTGSISPRLSLRPPSMASPTIRSAVLANPTNGTTSTALPALGRNDSPPSKMSPGTSTNPSRAAGVMSFSNILSSSEPVPRPRATSPNNPDDDDDVPMKVERADSSEKVVKEKKERKPRQPKQPRISDIRHSESTPKGRRGSTKQESPLPNIRIPAKRMANGAPKQQKTFSAENEEKIRKAMDRIETRELPHEDEFEEELRLWRERREYKRQQMNQRDLRQRRQRRADYTEVEAQKLKLHADFGKRRYDDLNYDDALQEVRERELFAEKERKKDMQRKRRREKSMATTMEAKAAALARASAAQDEAERQKYMREAERANKKVQQTRLILQKGIKGPSRNTGPIEPNLEGGTMATFQAENMEPGKTKGKGRAGARPKKSKEQKQAEKDAAEAAQAALDAGLELPPKEETNKIRIKLTKTKAPKEADVDKDKENKEPQEPKEPKEPKEKVIKEKVVEEPKDPLELKFQSKGFNQIYDQIWRDLARKDVNKVFRLAIDSYSTKSSNLKKTAILASKEAKRWQLRTNKGTKDLQARAKRVMRDMMGFWKRNEREERDLRKAAEKQELENARKEEADREAARQKRKLNFLISQTELYSHFIGKKIKTNEVERSTDHPDEIAAEKDKIPENEMDIEVPTGPIGAKVTNFENLDFDAEDESTLRAAAMANAQNAIAEAQKKAREFNKEESKLDEDGEMNFQNPTMMGDVEIEQPKLLNCQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAEKYDIWGPFLVVAPASTLHNWQQEITKFVPQFKVLPYWGTAGDRKVLRKFWDRKHTTYKKDAPFHVMITSYQLVVSDVAYFQKMKWQYMILDEAQAIKSSQSSRWKCLLGFHCRNRLLLTGTPIQNNMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLRRVKKHVQKELGDKIEMDVFCDLTYRQRAMYANLRNQISIMDLIEKATLGDDDSASLMNLVMQFRKVCNHPDLFERADTASPYSFGHFAETASFIREGSQVTVGYSTRSLIQYELPRLLWRDGGRLHKAGEDNQVAGWRNQWLNEKFNIWTPEHIRESLAGTDNFSWLRFADTSYEEAYRASHKDLFARAVEMSTKKNRLAEIKIAYDEPEDLNFTPAHALFHIREREDRRPLAEITEQGILGSLMNVSRSAFSETGLGRLEQAAAPKASAPPIEVVCDSRSAVVERENIMFNAPMRKVLFGPTLAEEKALVVQKVPPSRYPPPALLPAPDKEKQKFTNITVPSMRRFVTDSGKLAKLDELLRELKENGHRVLLYFQMTRMIDLMEEYLTYRNYKYCRLDGSTKLEDRRDTVADFQTRPEIFIFLLSTRAGGLGINLTSADTVIFYDSDWNPTIDSQAMDRAHRLGQTKQVTVYRLITRGTIEERIRKRAMQKEEVQRVVITGGSSAAGGGVDFSGRRAPENRNRDIAMWLADDEQAEMIEKRERELLESGELDKMQKKSRGGNKRKRGGAGGEGKEVSLDEMYHEGEGNFDDGGNNIKGSGTATPNGAAGGEGGDGKGAVGGAAKKRKTGGSKKAKTTKQRLAIADGEIDI", "function": "ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.", "AFDB_id": "AF-Q872I5-F1-model_v4" }, { "swissprot_id": "Q8GW43", "sequence": "MADHSWDKTVEEAVNVLESRQILRSLRPICMSRQNEEEIVKSRANGGDGYEVFDGLCQWDRTSVEVSVSIPTFQKWLHDEPSNGEEIFSGDALAECRKGRFKKLLLFSGNDYLGLSSHPTISNAAANAVKEYGMGPKGSALICGYTTYHRLLESSLAQLKKKEDCLVCPTGFAANMAAMVAIGSVASLLAASGKPLKNEKVAIFSDALNHASIIDGVRLAERQGNVEVFVYRHCDMYHLNSLLSNCKMKRKVVVTDSLFSMDGDFAPMEELSQLRKKYGFLLVIDDAHGTFVCGENGGGVAEEFNCEADVDLCVGTLSKAAGCHGGFIACSKKWKQLIQSRGRSFIFSTAIPVPMAAAAYAAVVVARKEIWRRKAIWERVKEFKELSGVDISSPIISLVVGNQEKALKASRYLLKSGFHVMAIRPPTVPPNSCRLRVTLSAAHTTEDVKKLITALSSCLDFDNTATHIPSFLFPKL", "function": "Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Required for the biosynthesis of D-biotin that prevents light-mediated cell death and modulates defense gene expression, probably by avoiding hydrogen peroxide H(2)O(2) accumulation.", "AFDB_id": "AF-Q8GW43-F1-model_v4" }, { "swissprot_id": "A5UUG7", "sequence": "MTEVVHLHMPEEARATQSRDATPRERRYYVWTVGCQMNVSDSERLEAALQGVGYAPAERPEDASFIVLNSCSVRASAEERILGKLSEVQRLKRKHPDTKVVLWGCMVGPGNQSIFQSRLPMVDHFVSPSAVDEVLALAPNPIYQLEEPALPVARWDHPPVSVHVPIQYGCNMSCSFCVIPLRRGRERSRPLDEIVEECRRIVARGAKEITLLGQIVDSWGHDLPGRPDLADLLRAVHDIPGLLRLRFLTSHPAWMTDRLIAAVAELPRCMPDINLPVQAGDDALLKIMRRGYTVQRYRDLIAKIRDAIPDVSLTTDVIVGHPGETRERFEGTKRLLEDIRFDKVHIAAFSSRPGTRAADMELDPTLAVPEGEKQLRRIELERLQEQIAAERNARFLHQTVEVLVEGEHKGKWRGRTPGNKLVFFSDPDDWTGRLARVIITHTGPWSLQGVLARSDETFARVNGALHAVAAANGAAV", "function": "Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.", "AFDB_id": "AF-A5UUG7-F1-model_v4" }, { "swissprot_id": "Q58833", "sequence": "MGITMFKEFKALLSFFTRIPIYVEDFDFENIANYFYLIILIGYVFGIFSLILGYIFSFLLPNFLSAVLILFFIEYLNGFHHIDGLIDFGDGWMAVGDKRKKLMAMKDRYIGCGGVVFAIFFNLMAVISLSYILDINILYLLVGEVCAKLGMLSCSTFGNPLIEGTGRYFVKKADEKFLTIGIILSLPLLLIFSGIERKIVIIAIITTIITGLCMAKIAKRHFGGVNGDVLGASNEITRVVVLLSIIASIKVFSIYLLG", "function": "Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.", "AFDB_id": "AF-Q58833-F1-model_v4" }, { "swissprot_id": "P46745", "sequence": "MNAPITQKNTAYISSDKLSLLELENSNKFINLLMVDGKKSRAIRLFYDTLVLLKRKNLKENSKKESLLGIIGQLSPKNSIEDLVNNSNKLSNNSNEEIKIPLIDNSKSDDKSNLLETISVLEVLSIALKNVTPSVELRKVRRAGNTFLIPAILSQHKANTLAIRWVIESAKKKQQNSKQNFAECLADEIYQAYLKQGKARQKRDELHSAAISNRANIRYRWW", "function": "One of the primary rRNA binding proteins, it binds directly to 18S rRNA where it nucleates assembly of the head domain of the small subunit.", "AFDB_id": "AF-P46745-F1-model_v4" }, { "swissprot_id": "Q6LXQ9", "sequence": "MYENTNSEENNNNIQSQNMDIQKFKKYIRTEKKADERPKVIVMGRSNVGKSTFVKLVTGKNVRVGKKPGVTLKITEYDMGTYILVDLPGFGFMEGIEKKAQEKIKDEIIHYVEDNKDAIAASIHILDAKSFIDIVERWGNKGEVPIDLEMADFLEELELNPIFVVNKMDKIKNSEWDNHLDKVSETLGFLPPWRQWLDNFVPAIMRDNYGIDGIKHRINKRINIFKKSKK", "function": "Necessary for normal cell division and for the maintenance of normal septation.", "AFDB_id": "AF-Q6LXQ9-F1-model_v4" }, { "swissprot_id": "S4WUL1", "sequence": "MELLKGSGLNQTESGGSSSTESSSLSGGLRFGQKIYFEDGSGSGSGSSKNRVHNTGRKSLTARCQVEGCRMDLTNAKSYYSRHKVCCIHSKSSKVIVSGLPQRFCQQCSRFHLLSEFDLEKRSCRRRLACHNERRRKPQATTSLLSSRYARTAPSLYGNANSAMIRSVLGDPTAWATARSAMRWSGPERESHQVMNVFSSHGSSSFTTTCPEMMMNNNGTDSSCALSLLSNTNPNQQLQQHQLQTPTNVWRPSSGFNPVIADRVTMAQPPPVSIHNQYLNNQTWEFTTGEKSNLQYMSPVLGPSQISQPADFQISNGSTMGGFELSHHQQVLRQYMEPENTRAYDSSPQHFNWSL", "function": "Probable transcription factor required for the flowering response to vernalization in the shoot apical meristem (SAM). Defines the competence of shoot meristems to flower in response to vernalization in perennials.", "AFDB_id": "AF-S4WUL1-F1-model_v4" }, { "swissprot_id": "Q59L86", "sequence": "MKVTAVSSVLLTVAALTNANEIDKRSFFGDLFSGLTGSKAAAPAAAPAAQPAAQPTTQSPADQPTVQSPVSSDQPSTAQPVAQNNLLLDSSNSTLVVPSSSKSSTTTRSTAGLLDNLLGGSGATSSEASSSEAPSSEAPSSEAPSSEAPSSEAPSSEAPSSSSSEALSSSSTTKRPTAAAKGFFGDLFGTQSSASETDDEDCVEETESPTSAPASAPTTSKVATTTGGGLPNILSDLFPGKSSAPISSAESSPTVASSTTGFPNILSDLFPGKSSVPSSSAETSTTVASNTTTSGGGFPNILSDLFPGKSSVPSSSAEEDDEECEDPTESVTSNSSPTGGISIPTFPITSQSKTSVSSVVSKSTSEDDDDETECETDIPTIIPSGSVLPTTSVLPTIIPTGSGSITILPTKSATSDDDDDETDCETDIPTIVPTESATIIPTGSGSVTIIPTGSGSITVLPTKSATSDDDDDETDCETDIPTIIPTGTATIKPTGSGSITVLPTKSTTTDDDDDETDCETEIPTIHPTVSTTRTFTSDGVPTTQTLTTKLPPTTNQHTETEVVSITYTGGGQTFTTYLTQSGEICDETVTLTITTTCPSTTVAPGGQIYTTTVTVITTHTVYPDDWEDDGYEGEDNAGGSASGSSDDGEWEWYEEDDGECVPTGGSSSGSGTGSWWGSGAGSSGGTTSGSGSGSSSNSGASSGGTWGGSGNDYVCPGEEGYDDEEPDNGGSWWGGSGSGSSSGSSSGVSSGDSGSSSVTGGSSGSWWGGSGNDYVCPGEDGYDDEDDQTPEPECDDEDDSWDDDEECDTQAAKEVVNSVTVAAESVYPSTTAASLTTSWISTQTAQSVTQIENIGGKVSASGLFVVLGLLLI", "function": "Probable GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.", "AFDB_id": "AF-Q59L86-F1-model_v4" }, { "swissprot_id": "Q14242", "sequence": "MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP", "function": "(Microbial infection) Acts as a receptor for enterovirus 71.", "AFDB_id": "AF-Q14242-F1-model_v4" }, { "swissprot_id": "Q2TW69", "sequence": "MFGSPKRAALAAASLLAVFGNGPSVMAQETSSNNAVVADGKTFALNGENVSYRFRVNETTGDLVSDHFGGSITGNLFPGFGAEALGGWVGLAGRFRREFPDHGRGDFRIPAVRIRQEAGYTVTDLQYQSYSVIPGKPALPGLPSTFGSEEDVTTLVVHLYDNYSSIAVDLSYSIFPKYDAIVRSANVTNKGTQNITVEALSSFSFDFPYEDLEMISLRGDWAREAHRQRRKVEYGLQGFGSSTGFSSHLHNPFLAIVHPSTTESQGEAWGFNLVYTGSFSVDVEKGSQGLTRALLGFNPSQLSWQLGAGETLTSPECVSVYSSDGIGGMSRSFHRLYRNHLIKSKFATSDRPPLLNSWEGLYFDYNESTIYRLAEESAALGVKLFVMDDGWFGDKYPRVSDNAGLGDWVPNPDRFPDGLTPLVEDVTKLKAGNSSTDLRFGLWVEPEMANPNSTLYHEHPDWVLHAGQYPRTLQRNQLVLNLALPEVQDYIIDEITNILNSSAISYVKWDFNRAMHETPSPSNDHEYILGMYRVFDTLTTRFPDVLWEGCASGGGRFDPGVLEYFPQIWTSDNTDALMRITIQLGTSLAYPPSAMGAHLSAVPNAQTGRTIPVKFRGHVAMMGGSFGLELDPAELQEDEKAEVPGLIALAEKVNPIILTGDMWRLRLPEESNWPAVLFISEDGNQAVLFYFQLGPNVNHATPWLRLQGLDPKATYSVDGNGSYSGATLMNMGLQYKFESDYDSKVVFLQKQ", "function": "Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.", "AFDB_id": "AF-Q2TW69-F1-model_v4" }, { "swissprot_id": "P17222", "sequence": "MSELSYLEKLMDGVEVEWLPLSKVFNLRNGYTPSKTKKEFWANGDIPWFRMDDIRENGRILGSSLQKISSCAVKGGKLFPENSILISTSATIGEHALITVPHLANQRFTCLALKESYADCFDIKFLFYYCFSLAEWCRKNTTMSSFASVDMDGFKKFLIPRPCPDNPEKSLAIQSEIVRILDKFSALTAELTAELTAELSMRKKQYNYYRDQLLSFKEDEVEGKRKTLGEIMKMRAGQHISAHNIIERKEESYIYPCFGGNGIRGYVKEKSHDGEHLLIGRQGALCGNVQRMKGQFYATEHAVVVSVMPGINIDWAFHMLTAMNLNQYASKSAQPGLAVGKLQELKLFVPSIERQIYIAAILDKFDTLTNSITEVSRVKSSCARNSTNIIEICYLVSRSRK", "function": "The specificity (S) subunit of a type I restriction enzyme; this subunit dictates DNA sequence specificity. The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues of the sequence 5'-CCAN(7)ATGC-3'. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.", "AFDB_id": "AF-P17222-F1-model_v4" }, { "swissprot_id": "P26967", "sequence": "MLVQITALAFLAGIASAGVVVGGYGDGVGVGLGGLGGGLGGVGVGLGGVGVVGGGHGVVDLHTPAHYQFKYGVEDHRTGDRKQQAEVRVGDVVKGEYSLAEPDGTVRVVKYTADDHNGFNAVVSRVGHAVHPQVLVRKAVVPVATHGVVGVGGLGGLGGVGLGGVGLGGVGLGGGLGGVGLLGGRGGLDRGILGGHGGSELKFKRALI", "function": "Cuticular proteins play a significant role in determining the physical properties of cuticles.", "AFDB_id": "AF-P26967-F1-model_v4" }, { "swissprot_id": "U3KRF8", "sequence": "NEQANLRLSEANSGTYKTFIGRVREELGSETYRLYGIPVLKHSLSNSNRFYLLTLTSNQDESITLAIDVEDMVAVAYQPAGSHESYFFLNAPQIAFHTLFTDTHQNVLNFDNTFKSLENAAGTTRQTIVLGVDPLDFAISNLFNADPKLLPLSFLVIIQMVLEASKFRFIEQSVAYSFKNEKTFLPDLAIVSLEDNWSEISLQIQASTSLQGLFGSVVELYNSNNELIEVDSIYYPIILANVALQLYHCQVSTGDNECLVETRTTRISGRDALCVDVAGALTSDGSRLILYPCGQQVNQKWTFHSDGTVRSLGKCLATNNSKFGNLVVIYDCSKLAAEDISWDVSVGGTIMNPNYEDLALTSNKATRSTNLTMEVNTYSASQGWRVGNYVQPIIGSIVGLDDMCLEATDGNTNMWLEECVPNQREQSWALYSDGTIRVDDNRELCVTASSSTYDNWKVITILNCDGSNNQRWVFLADGSISTPGNQRLAMDVARSDVDLKKIILHRPHGDLNQQWVLFY", "function": "Seed lectin similar to type 2 ribosome-inactivating proteins. The Aalpha and Abeta chains constitute the rRNA glycosidase domain and the B chain the carbohydrate-binding lectin domain. Is predicted to have no glycosidase activity and, hence, to be non-toxic, due to small changes in both the nucleotide binding and carbohydrate binding capabilities. Binds galactose and derivatives with a preference for the beta-anomeric forms. Binds prophyrins. Has hemagglutinating activity towards rabbit and human erythrocytes.", "AFDB_id": "AF-U3KRF8-F1-model_v4" }, { "swissprot_id": "Q28858", "sequence": "YPIRAPRVGCYGDMMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTAPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKRRMSDLSVIGHPIDSESKEDEPCSEETDPVHDLMAEILPEFPDIIEIDLYHSEENEEEEEECANATDVTTTPSVQYINGKHLVTTVPKDPEAASGTISTNFPQTMEPAKLWSRQEVNPERQEIESETTSEEQIQEEKSFESPQNSPATEQTIFDSQTFTETELKTTGYSVLTTKKTYSDDKEMEEEGTSLANMSTPVPDANGVESFTTLPEATEKSHFFLATALVTESIPAEHVVTDSPIKEEESTKHFPKGMRPTIQELDTELLFSGLGSGEEVLPTLPTKSVNFTEVEQIRNTFYPHTSQVESTSSDKLEDFNRMENVAKEVGPLGSQTDIFEGNESVTSTTLIEILSDPGAEGPTVAPLPFFANIGHPQNQTLRWAEEIQTSKLEPSEEDGKPELLEETEASPTEFIAVEGTEILQDFQNKTDGQVSGEAIKMFPTIKTPEAGTVITTANEIKLEGATQWPHSTSASATYGIEAGVMPWLSPQTSERPTLSSSPEINPETQAALIRGQDSTVAASEQQVTARILDTNDQATVSPVEFNTEVATPPFSLLETSNETDFLIGINEESVEGTAIYLPGPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCADGFNTFRCLCLPSYVGALCEQDIETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQWIGLNDKMF", "function": "May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronan.", "AFDB_id": "AF-Q28858-F1-model_v4" }, { "swissprot_id": "Q9LSC4", "sequence": "MAVSVSAPVLSLCYNQSGELSRSLGYRLPKKVGFSSGRRSVSYIGFGAEKVGRFRVRVPICRAVPPLLFKDLDADDFRHPFDKQNTLLLRAIPGLNEFGKALLGSMTEQIMLLENIGTSVLVSKNQLSDLHGLLVEAAEILNIEAPDLYVRQSPVPNAYTLAISGKKPFIVVHTSLIELLTSAELQAVLAHELGHLKCDHGVWLTFANILTLGAYTVPAFGQMIARTLEEQLLRWLRSAELTCDRAALLVAQDPKVVVSVLMKLAGGCPSIADQLNVDAFLEQARSYDKASSSPLGWYIRNAQTSQLSHPLPVLRAREIDEWSRSLEYKSLLKRANRKSTVQKV", "function": "Metalloendopeptidase with a Zn-dependent proteolytic activity and substrate cleavage upstream of hydrophobic residues. Positive regulator of senescence, probably by degrading CCD4, thus participating in the controlled removal of carotenoids from the thylakoid membrane during the senescence process.", "AFDB_id": "AF-Q9LSC4-F1-model_v4" }, { "swissprot_id": "A0A075B6W5", "sequence": "MDKILGASFLVLWLQLCWVSGQQKEKSDQQQVKQSPQSLIVQKGGISIINCAYENTAFDYFPWYQQFPGKGPALLIAIRPDVSEKKEGRFTISFNKSAKQFSSHIMDSQPGDSATYFCAAS", "function": "V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.", "AFDB_id": "AF-A0A075B6W5-F1-model_v4" }, { "swissprot_id": "Q6F9N7", "sequence": "MQKIQSNQIQEQDLTPELKKWLYASGSLTQQLTDLADGLFTVEPIQEKYQRMSFMDSRWMRMPAYHVAWVRESLLYGCEQQPWVKAKSIFPVLSLQKKARIFKHIGKKPIGRFLFQRTTPLCERRVIRLEEGWTRQSCYTWHGCKFIVQETFLASFEQYIQHHSHSI", "function": "Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.", "AFDB_id": "AF-Q6F9N7-F1-model_v4" }, { "swissprot_id": "Q6EVZ2", "sequence": "MILKYSLLGNLLLLWINIVNSVVMVGLYYGFLTTFSIGPSYLLLLRTRVMKEGSEKEVSATTAFIMGQFIVFISTYYPPLHLALSRPHTLTVLVIPYLLSHFWFFWNNKKSLFDYRSTHGNFIPNLSIQYVFLNNLIFQLFNHFVLPSSTLTRLVDISMFRYNNKILFVTSSFFGWLIGHMLLMKCIGLVLSWPWEKMRSNALFRSNKYLMSKWRNSVSQIFSILLFIICICYLGRMPSPIITKKLKESSKREEKKKTEEEGNVEIERVSKTNKIKQEEDGSVEEDLSISLEMEERWNLYKKIYETEEIWLNGKEKDEFDLKEKEKNKLLGIEKSLLSLLFDYQRWNRPLRYIENDRFSNAVRNEMSQSFFYTCASDGKQRISFTYPPSLSTFFEMIKKKMSFRTAEKLPAEDLSNEWVSTTKKQRDNLRNEFINRIEAIDKGSLILNVVEKRARLCNDEEEQECLPKFYDPLLNGPYRGTRKKGYLYSIRNDSTTSTRGSTKTAWINKIHAILFSKDYREFEREFEHEMYKLGVKSSSTGIEDSSVSIGEFTEEAEEAEKSRTRFKQFAFGGEEKVFEKVFDMVRADPNDQKISNLPIEEIKKKVPRWLYKLTSDLDFEEEEEEEEEDDQEESTDDHGIRSRKGKRVVIYTDTNQGTNIINTTNNIIKTHDNIIKTTNDNIIKTTTDNIINTNDNIIKTTDNIINTNDNIIKTTDNIINTNDNIIKTTDSNREKNSDDKVENGDQAEENEMALIRYSQQSDFRRDLIKGSMRAQRRKTVTWEMFQTDAHSPLFFDRIDKTPLFSFDISRMMNLIFRNWMEEKSPKMKTSSYVGEGAKEKEKIEEEHEEEKGEYKRKEDKRQEEERIAIAETWDNIIFAQAIRGSILVTHSILRKYIVLPSLIIVKNIGRMLLFQFPEWYEDFNEWSREMHVKCTYNGVQLSETEFPKDWLTDGIQIKILFPFSLKPWHRSKLRSHHKDLRKKQKNFCFLTIWGMETELPFGSPRKKPFFFEPIHKAFEKKIIKVKKKGFFFLIIIKDNIKGFIKILNEKIRWIIKIVLFIKIKVKEVFFFFVLRRVSDPSQNEEPSKNEKDSKISNRIIHESPIRIVSRDWTNDSLIEIKINDLADKTTKIWDQVEKIRKDKKKKPLTPDIEDIDISTNKGNCSNKRTESRKHIWQISKKRRSARLISKWDSFMKSFIERIYMSILLCITNIYRIYVQFFLDSTKKTLNGYTYNDEIKEKDTNEPNPNIIPFISTVKSLSTYTTNISSDSNSPIYCDLSSLSQAYVFYKLLQTQVSNKYKSESIFHYYRTYPFIKDGIKDYFHDYFHTRGIFDSESKHKKLRNSGMSEWKNWLKSHYQYNLSHDKWSRLAPLKWRKKVNQHRTIQNNDSPKSGSYEEKDQLIHSGKKDYSKLGLLKSPSREMKSPSREKKIKKHYRYDLLSYKYLNYEDVKDSNIYGSPLQVNRHGEISNYNTHKYKSFYAITINDSLEDKYTIDRDQNLDRKYFELRITNFDPRNNIETRTSTDIGTFINKKKKTTKTGTNKKDILSLYIRIHQEIQTKQKEFFFDWMGMNEQMLDRTISNLRPWFLPEFVPLYDRYTTNPWIIPINLILFDFHGNKTSDLYIDPKVESNQKERFHPKPKVESNQKGYLELENRNRDEKERQHQGNLISDIRNKKKDVGANSAGSDIKKRRKKKKFKSKKEAELDLFLKKYFIFQLRWDDPFNKGMNNNIKVYCLLLRLMNPNEIAISSIQSGEMGLDVMLINRGFSLPELIKKGIFLIEPVRLSIKRDGISIMYQTIAISLTHKIQHQTNQGYQLKKYIDKNYFNGSIARHGGVRVNGDNNNYDLLVPEHILSPSHRRELRILSRFNYRNRNLVNKNPVFCNRAKTNAQGFEKFVNRDKHFHTDTNNSLKWKVFLWPTHRLEDLACMNRYWFDTNNGSRFSMSRIHMYQQFGIRGCYSQFPSLSRAWYMRTCK", "function": "Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.", "AFDB_id": "AF-Q6EVZ2-F1-model_v4" }, { "swissprot_id": "Q9Z0G7", "sequence": "MEPSALSPSGATLPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRSAATTTTVTTAAAPSVSVPCASVPSGNGGTVAPATVGSVRSHTSSRASENQSPSSSNYFSPRESTDFSSTSQDAFVASAAGSGNRRDGGPVFPAPVVGSAGTTSGKLLLEADELCDDGGDGRGAVAPGAGLRRSNCMPASAVPQKHWVYVKQARNCPAPASLVHQDPDLEDEEEEEDLVLTCEDDEDEEMGGGSGVPAGGEPEATLSISDVRTLTEPADKGEEQVNFCESSNDFGPYEGGGAGAGLDDPGGPTPSSYALTHPPRPLLPLDVPGNQILVFPSSSSQAPGQPPGNTAEHGAVTLGGTSAVGLGIPSGSGGAPGGTGNSDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECSVCAKKFMWRDSFMRHRGHCERRHRMGVGGVGSGPGPGPGPGTPSGPALQPKRESSTVGGGSGDEANSATPPSHRRVWSPPSVHKVEMDFSGGGGAAH", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q9Z0G7-F1-model_v4" }, { "swissprot_id": "Q8VY78", "sequence": "MDGEELTEQETALYDRQIRVWGANAQRRLTKAHILVSGIKGTVAEFCKNIVLAGVGSVTLMDDRLANMEALNANFLIPPDENVYSGKTVAEICSDSLKDFNPMVRVSVEKGDLSMLGTDFFEQFDVVVIGYGSRATKKYVNEKCRKLKKRVAFYTVDCRDSCGEIFVDLQDYKYTKKKLEEMVECELNFPSFQEAISVPWKPIPRRTAKLYFAMRVIEVFEESEGRKHGECSLLDLARVLEIKKQLCEANSVSESHIPDILLERLITGTTEFPPVCAIVGGILAQEVIKAVSGKGDPLKNFFYYDGEDGKGVMEDISDSFTS", "function": "The dimeric enzyme acts as an E1 ligase for SUMO1 and SUMO2. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. Functionally redundant with its paralog SAE1B.", "AFDB_id": "AF-Q8VY78-F1-model_v4" }, { "swissprot_id": "P17791", "sequence": "MLKATGPLSIILLASTCPSSGAAPLSFAEFNNFARECAPSVAPSTLAAIAQVESRFDPLAVHDNTTGETLHWQNQAQATQVVMDRLEARHSLDVGLMQINSRNFSVLGLTPDGALQPCTSLSVAANLLGSRYAGGNTADDEQLSLRRAISAYNTGDFTHGFANGYVRKVETAAQQLVPPLTARPKDDREKPGSEETWDVWGAYKRRSPEGGAGGSSGPPPPPDEDNRKSEDDDQLLFDLNQGGPQ", "function": "VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.", "AFDB_id": "AF-P17791-F1-model_v4" }, { "swissprot_id": "Q2RY21", "sequence": "MADPAFVPLRPIAIKDRSSIVFLQRGQLDVVDGAFVLIDQEGVRVQIPVGGLACLMLEPGTRITHAAIVLCARVGCLVIWVGERGTRLYAAGQPGGARADRLLFQARNALDETARLNVVREMYRRRFDDDPPARRSVDQLRGMEGVRVREIYRLLAKKYAVDWNARRYDHNDWDGADIPNRCLSAATACLYGLCEAAILAAGYAPAIGFLHRGKPQSFVYDVADLYKVETVVPTAFSIAAKIAAGKGDDSPPERQVRIACRDQFRKSGLLEKIIPDIEEILRAGGLEPPLDAPEAVDPVIPPEEPSGDDGHRG", "function": "CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.", "AFDB_id": "AF-Q2RY21-F1-model_v4" }, { "swissprot_id": "K0DZA0", "sequence": "MAITTLDFNQFRSTSADERQIFCADLCETLSVYGFAKIRNTTLSNELIDEIFKYTRSFFALPNDIKAKAKHPNAPNPHRGWSAIGQERVWKISGFEQNKERTDSYNEFRESFDQGAADDQLFPNRWVDEDDLPGFQAFMEGFYKSCDELHAHLLRAISTGLKLPDTLLPSKHRHNTSELRLLHYPPIPCSALRSNMRIGEHSDFGTLTLLLQDSVGGLQVEDQRNPRSFIPVEPEDGYEVVINIGDCLQRWTNRRLCSANHRVMLPEGKDVDSEEVLDDRYSVAYFGKPDRDVLVDTLPECVEVGERVEYGDHLTALQYNQIKLTRTYG", "function": "2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the de novo generation of L-homotyrosine from acetyl-CoA and 4-hydroxyphenyl-pyruvate. L-homotyrosine is a building block of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent. L-homotyrosine 4-hydroxyphenyl-pyruvate first undergoes an aldol-type condensation by htyA with the C-2 of acetyl-CoA followed by the release of CoA to form 2-(4-hydroxybenzyl)-malate. This is followed by isomerization of 2-(4-hydroxy-benzyl)-malate to 3-(4-hydroxybenzyl)-malate by htyD. Thereafter, 3-(4-hydroxybenzyl)-malate undergoes decarboxylation and oxidation to form 2-oxo-4-(4-hydroxybenzyl)butanoic acid, coupled to reduction of NAD(+) to NADH by htyC. The product then undergoes transamination catalyzed by htyB to form L-homotyrosine.", "AFDB_id": "AF-K0DZA0-F1-model_v4" }, { "swissprot_id": "Q97LF7", "sequence": "MKKLLYISVNTKPEGMSASKTVGREFVDRFVQNYPEYQLIEHDICNEYIPELDHRFLNDNGDIVSGNDYNLLSDNDKKIVDRINDLCNEFVSADVYVIAYPMWSSLFPPRLKMYIDCIVQNGKTIKISEDESSGLLSDKERSVLCIQSSGGVYPKIISWKINHGINYLHDIFRHLGIKKFEKLLVEGVDVQDIGKEKAVEKAFDEIDELIDKMQVRDFVKQ", "function": "Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.", "AFDB_id": "AF-Q97LF7-F1-model_v4" }, { "swissprot_id": "P42939", "sequence": "MNNNVEELLRRIPLYNKYGKDFPQETVTRFQMPEFKLPALQPTRDLLCPWYEECDNITKVCQLHDSSNKKFDQWYKEQYLSKKPPGIVGNTLLSPSRKDNS", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Appears to be involved in cargo sorting and release of the ESCRT-I complex from the MVBs.", "AFDB_id": "AF-P42939-F1-model_v4" }, { "swissprot_id": "Q84LK0", "sequence": "MHWIATRNAVVSFPKWRFFFRSSYRTYSSLKPSSPILLNRRYSEGISCLRDGKSLKRITTASKKVKTSSDVLTDKDLSHLVWWKERLQTCKKPSTLQLIERLMYTNLLGLDPSLRNGSLKDGNLNWEMLQFKSRFPREVLLCRVGEFYEAIGIDACILVEYAGLNPFGGLRSDSIPKAGCPIMNLRQTLDDLTRNGYSVCIVEEVQGPTPARSRKGRFISGHAHPGSPYVYGLVGVDHDLDFPDPMPVVGISRSARGYCMISIFETMKAYSLDDGLTEEALVTKLRTRRCHHLFLHASLRHNASGTCRWGEFGEGGLLWGECSSRNFEWFEGDTLSELLSRVKDVYGLDDEVSFRNVNVPSKNRPRPLHLGTATQIGALPTEGIPCLLKVLLPSTCSGLPSLYVRDLLLNPPAYDIALKIQETCKLMSTVTCSIPEFTCVSSAKLVKLLEQREANYIEFCRIKNVLDDVLHMHRHAELVEILKLLMDPTWVATGLKIDFDTFVNECHWASDTIGEMISLDENESHQNVSKCDNVPNEFFYDMESSWRGRVKGIHIEEEITQVEKSAEALSLAVAEDFHPIISRIKATTASLGGPKGEIAYAREHESVWFKGKRFTPSIWAGTAGEDQIKQLKPALDSKGKKVGEEWFTTPKVEIALVRYHEASENAKARVLELLRELSVKLQTKINVLVFASMLLVISKALFSHACEGRRRKWVFPTLVGFSLDEGAKPLDGASRMKLTGLSPYWFDVSSGTAVHNTVDMQSLFLLTGPNGGGKSSLLRSICAAALLGISGLMVPAESACIPHFDSIMLHMKSYDSPVDGKSSFQVEMSEIRSIVSQATSRSLVLIDEICRGTETAKGTCIAGSVVESLDTSGCLGIVSTHLHGIFSLPLTAKNITYKAMGAENVEGQTKPTWKLTDGVCRESLAFETAKREGVPESVIQRAEALYLSVYAKDASAEVVKPDQIITSSNNDQQIQKPVSSERSLEKDLAKAIVKICGKKMIEPEAIECLSIGARELPPPSTVGSSCVYVMRRPDKRLYIGQTDDLEGRIRAHRAKEGLQGSSFLYLMVQGKSMACQLETLLINQLHEQGYSLANLADGKHRNFGTSSSLSTSDVVSIL", "function": "DNA mismatch repair protein specifically involved in maintenance of mitochondrial genome configuration by controlling specific rearranged portion. Functions by suppressing asymmetric recombination at some repeat pairs.", "AFDB_id": "AF-Q84LK0-F1-model_v4" }, { "swissprot_id": "O34138", "sequence": "MTPSAAATGHEAADEQRLRELRGLTRQLPTGVAVVTAQDGEVAHGATVSTVSVLSQQPLRIGVSLRRGSYLTGLIRQRRVFALNVLSSRQSAVADWFANPERPRGWRQFDYVRWTAHPKAGMPVLEDALAQLHCRLTDLIPLGASDDLLVAEVLDGRGRNGRPLVNFNGRLHDVEFRGVVRVSRDQPSAVTSLE", "function": "Involved in the biosynthesis of the azoxy antibiotic valanimycin, which has an antitumor activity. Catalyzes the reduction of FAD/FMN to FADH(2)/FMNH(2) which are subsequently used for the hydroxylation of isobutylamine by the isobutylamine N-hydroxylase VlmH. It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a strong preference for NADPH as acceptor.", "AFDB_id": "AF-O34138-F1-model_v4" }, { "swissprot_id": "P70900", "sequence": "MRKRISAIIMTLFMVLASCSNQLEAEKLAAESKNTFFDSLVKIGQGFQDIFGILEMQLGDALGFNAVKSGDKKSKVGEHFKKIGDGLTTTKDKLKELSNKISEAKNANSSTIEAVKSAINSASDVFEQLITALTKLADTAKEAGDTNIGDNADAVPGAAEKTGVEAIIAGVKDIIGAAEKSGVKIEYGNAGDPIATAANTTDALAVLGGNTAKATQGAGDKLAFEVSKADPWAIIDKIKNAKAADGIQLDAGEKDAGTLAASNNNASANAGAESNAASSSSWLFLMQLSKGGKFSAAVADAGAVKAAAVSAVNKVLGVLDFIIRKTVSSNLDKIREAVKGIKYSEITETDATESGDAQPITNKSSN", "function": "The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune response evasion.", "AFDB_id": "AF-P70900-F1-model_v4" }, { "swissprot_id": "P45741", "sequence": "MSKVKGFIYKPLMVMLALLLVVVSPAGAGAAHSDASSDITLKVAIYPYVPDPARFQAAVLDQWQRQEPGVKLEFTDWDSYSADPPDDLDVFVLDSIFLSHFVDAGYLLPFGSQDIDQAEDVLPFALQGAKRNGEVYGLPQILCTNLLFYRKGDLKIGQVDNIYELYKKIGTSHSEQIPPPQNKGLLINMAGGTTKASMYLEALIDVTGQYTEYDLLPPLDPLNDKVIRGLRLLINMAGEKPSQYVPEDGDAYVRASWFAQGSGRAFIGYSESMMRMGDYAEQVRFKPISSSAGQDIPLFYSDVVSVNSKTAHPELAKKLANVMASADTVEQALRPQADGQYPQYLLPARHQVYEALMQDYPIYSELAQIVNKPSNRVFRLGPEVRTWLKDAKQVLPEALGLTDVSSLAS", "function": "Degrades thiamine by replacing its thiazole moiety with a wide range of nucleophiles.", "AFDB_id": "AF-P45741-F1-model_v4" }, { "swissprot_id": "Q9UDV7", "sequence": "MQFVSTRPQPQQLGIQGLGLDSGSWSWAQALPPEEVCHQEPALRGEMAEGMPPMQAQEWDMDARRPMPFQFPPFPDRAPVFPDRMMREPQLPTAEISLWTVVAAIQAVERKVDAQASQLLNLEGRTGTAEKKLADCEKTAVEFGNHMESKWAVLGTLLQEYGLLQRRLENLENLLRNRNFWVLRLPPGSKGEAPKVPVTFVDIAVYFSEDEWKNLDEWQKELYNNLVKENYKTLMSLDAEGSVPKPDAPVQAEPREEPCVWEQRHPEEREIPMDPEAGAEPLVPAQDASSQVKREDTLCVRGQRGLEERAIPTESITDSPISAQDLLSRIKQEEHQCVWDQQDLADRDIPTDPNSESLISAHDILSWIKQEEQPYPWGPRDSMDGELGLDSGPSDSLLMVKNPPPAPPQPQPQPQPPQPQLQSQPQPQSLPPIAVAENPGGPPSRGLLDDGFQVLPGERGSGEAPPGGDRSTGGGGGDGGGGGGGAEAGTGAGGGCGSCCPGGLRRSLLLHGARSKPYSCPECGKSFGVRKSLIIHHRSHTKERPYECAECEKSFNCHSGLIRHQMTHRGERPYKCSECEKTYSRKEHLQNHQRLHTGERPFQCALCGKSFIRKQNLLKHQRIHTGERPYTCGECGKSFRYKESLKDHLRVHSGGPGPGAPRQLPPPPERD", "function": "Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.", "AFDB_id": "AF-Q9UDV7-F1-model_v4" }, { "swissprot_id": "Q96C55", "sequence": "MDTPSPDPLPSPLPGEEEKPLALSPPVPRGRRGRRPGGATSSNRTLKASLPRKRGRPPKSGQEPPLVQVQGVTAPVGSSGGSDLLLIDDQGVPYTVSEGSAAGPEGSGPRKAPHFCPVCLRAFPYLSDLERHSISHSELKPHQCKVCGKTFKRSSHLRRHCNIHAGLRPFRCPLCPRRFREAGELAHHHRVHSGERPYQCPICRLRFTEANTLRRHAKRKHPEAMGVPLCAPDPGSEPPWDEEGIPATAGAEEEEETEGKGEPA", "function": "May be involved in transcriptional regulation.", "AFDB_id": "AF-Q96C55-F1-model_v4" }, { "swissprot_id": "A0JMD4", "sequence": "MEEEPLLAGSINQGSGDYGAHSESCLHYPDEHTPRSRRLSYSVTDDSCNVEEDADADLYVQQAVVFIEDAIKYRSINHRVDSGSLRLYRWYYSNLCQWGLGLTIAVVLALAFIERPSSLTYTSDIRVKPKPWEPPCGMTEGIEIVCLCIFILDVTAKGYLIGWEEFRMNKWLLAYLIVITASVIDWMLSISMLCDENLRVRRLIRPFFLLQNSSLMKKTLKCIKRTLPEIASVILLLALHICLFTMIGMLIFAKSDDPKQNGEWQTYFRNLPKALSSLLVLLTTANNPDVMIPAYSLNRGYSIFFILFSVFGTYLLMNLMTAIIYNQFRGYLLMSVQTSIIRRRLGIRAAFEVLCCPGRGHTSTQAEGHVERVAVSMFLKVMERVHMKSYCRQAIVKAARRFPDGFISGEDFQRLFNELDKDFVKEHPPKPEYSSSGLQHIQYVYSHYYISVLGNAVALANVICICTVLVLNAEKSASEKNYFYMEIINCIFILYYLIEMLLKIVAFGWKGYLSYRNNIFDGFLTVLLLAIQIVIFITFKIPYVDVDPVPRHVMALWEMIRLVNMLIVFRFLRIIPEIKLMAVVASTIVDLVKNLRAFAGILLVVYYMFAVLGIWLFQGAISPPSNMSLVSNSSLENITGPYSMECGTFEQLEYWPNNFDDFASSLILLYNIMVVNNWHVFTDAYARYTTDWSLVYFVVWWLTSSVMWVNLFVALILENFTYKWDRSNGLSVEDVERIAYQSTVQLMFKEHVKEPTEEELLAQLHQHPHLHLSW", "function": "Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis.", "AFDB_id": "AF-A0JMD4-F1-model_v4" }, { "swissprot_id": "P45831", "sequence": "MVRMNEVFDCADPDQRARGIASAVAALKGGRLVVMPTDTVYGIGADAFDRAAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYTMPDGARELIRAFWPGALSLVVVHAPSLNWDLGDAHGTVMLRMPLHSVAIELLCEVGPMAVSSANVSGQPAAVDVDGARGQLGELVGVYLDAGPSAQQAASTIVDLTEATPRILRAGPVSVARIAEVLGVVPASLIA", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.", "AFDB_id": "AF-P45831-F1-model_v4" }, { "swissprot_id": "Q12094", "sequence": "MGKGKNKMHEPKNGRPQRGANGHSSRQNHRRMEMKYDNSEKMKFPVKLAMWDFDHCDPKRCSGKKLERLGLIKSLRVGQKFQGIVVSPNGKGVVCPDDLEIVEQHGASVVECSWARLEEVPFNKIGGKHERLLPYLVAANQVNYGRPWRLNCVEALAACFAIVGRMDWASELLSHFSWGMGFLELNKELLEIYQQCTDCDSVKRAEEEWLQKLEKETQERKSRAKEEDIWMMGNINRRGNGSQSDTSESEENSEQSDLEGNNQCIEYDSLGNAIRIDNMKSREAQSEESEDEESGSKENGEPLSYDPLGNLIR", "function": "Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Required for processing 35S pre-rRNA at site D.", "AFDB_id": "AF-Q12094-F1-model_v4" }, { "swissprot_id": "Q7VJ36", "sequence": "MRVEHIIGNIKDIDATHLDIDEVQIAWYDTKKKIARLNSQNGQVIAMKLAQAPKYGLNNGDILFLDEHKIIIISILPTWVLCMKPTHWHTMARLCYEIGNLHIPLFYNKDTMKLQAPFEQPLQRILEKQSIAFEKKWCVLDSKDRINITYPIASEPKLIQSPHFSIKITQKGLN", "function": "Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.", "AFDB_id": "AF-Q7VJ36-F1-model_v4" }, { "swissprot_id": "Q9I749", "sequence": "MGSTTSSQKFIARNRAPRVQIEYDVELYGAEKKVQLPFVMGVMADLAGKPAEPQAAVADRKFLEIDVDNFDARLKAMKPRVAFNVPNVLTGEGNLSLDITFESMDDFSPAAVARKVDSLNKLLEARTQLANLLTYMDGKTGAEEMIMKAIKDPALLQALASAPKPKDDEPQA", "function": "Core component of the H1 type VI (H1-T6SS) secretion system that plays a role in the release of toxins targeting both eukaryotic and prokaryotic species. Forms the sheath of the structure by assembling into tubules together with TssC1 resulting in the stacking of cogwheel-like structures showing predominantly a 12-fold symmetry. The sheath contracts to provide the energy needed for effector delivery.", "AFDB_id": "AF-Q9I749-F1-model_v4" }, { "swissprot_id": "A7F9K1", "sequence": "MSILRSPYQCLKQCGNYLVAARGSSIDTFDIKNGSYLSTWKSPVPESMSRSKTTEEETQTKNEDQNSETATPEFILESSAPPAKRRKLSITKESGENTGVVQQSKKKTKNSSPKILEPSPITALTITRDLQHVIAVTGEDKTIRVLAWEDTVEKGLRQISDRTMPKRPCALAITDDCNTIISADKFGDVYSLPLIPSPLVPSATENASVQKQAPKMFQPSASALTVHSARNLKALEAQKKQSNKVSEKTGPDFEHKLLLGHVSMLTDILVATLSGRQYILTADRDEHIRISRGIPQAHIIENFCLGHIEYVSRLCIPPTRPEILISGGGDDDLYTWNWLNGSLLSKTNLKSQVEALDTEKQSAQEAESKKIAVTGVYHARDEVSNQDIIIATSEGVPAAFIYFLTASNQLTHTQTLALPGNALSCTFSNPDLSSPFSLIISINNIHEPSSITTLKDANSSVANPLQFFKYENEKFVSVQQDGFAPQDSEGILDDQQKNNLCGLLYNVGNLRKMEDEE", "function": "Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.", "AFDB_id": "AF-A7F9K1-F1-model_v4" }, { "swissprot_id": "O31567", "sequence": "MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAMGTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVGLETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANAVNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQLGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQWTSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK", "function": "Part of the ABC transporter complex YfiYZ/YfhA/YusV involved in import of the iron-hydroxamate siderophores schizokinen, arthrobactin and corprogen. Binds the siderophores and delivers them to the surface of YfiZ/YfhA (Probable).", "AFDB_id": "AF-O31567-F1-model_v4" }, { "swissprot_id": "Q6F5E1", "sequence": "MTPSDICPAIELPSSSRCMRIDYVGHPDAFSSCSNLCPTNLLRCIYSVRKYVLVRALSNFEDNTMFCTLRRSKDANKSYAIHMDDPPFARTKGRLSAIACVDCRASKTRCTGEPEGCKRCTFRKRPCQYPNLRRSNTTQHGEQIEASSSTFTMSDEQGSLGMEVSGQGSLDAQDINFANELTPVETAATMSDTMMSSECVTLNDSTITSSTIPFSIDSDIDLWNDVTGMAGSDTTSLWDYNAGSNDNIAAISTKEYVCACFAQALKTYESAEVHLVWSGRAHTADIMGLLQQQKNTISDCERLLDCVQCIEKSAFVVLLISICGKVLRSVEDASRELRPRDSVTEPTTKSKDPSQACLNIDANSISRHQLDDDDRLVVLGSLFLNRVTKLRSLIAAIEMLVMKRNWHIQRDMVRQLKSRVRLIDT", "function": "Transcription factor involved in regulation of gene cluster that mediates the biosynthesis of aphidicolin.", "AFDB_id": "AF-Q6F5E1-F1-model_v4" } ]