Protein Function Description

Instruction: Predict the general functional description of the protein sequence.

Output: Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin . Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus . Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation . Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks . Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair .


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MQASRARLFKEYKEVQREKVADPDIQLICDDTNIFKWTALIKGPSETPYEGGVFQLAFSVPEPYPLQPPQVRFLTKIFHPNVHFKTGEICLDILKNAWSPAWTLQSVCRAIIALMAHPEPDSPLNCDSGNLLRSGDVRGFNSMAQMYTRLAAMPKKG

Output: Required for peroxisome biogenesis. Necessary for the developmental elimination of obsolete peroxisome matrix proteins. May be involved in the ubiquitination of PEX5, targeting it for recycling. Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture . Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments . Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin . Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X . Required to facilitate Xist RNA spreading . Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus . Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation . Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (By similarity). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (By similarity). Required during preimplantation development, probably acts by regulating chromatin architecture .


Instruction: What is the functional description of the protein sequence?

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Predict the functional description of the protein sequence below.

Input: MALKATALFAMLGLSFVLSPSIEANVDPHFDKFMESGIRHVYMLFENKSVESSEQFYSFMRTTYKNDPCSSDFECIERGAEMAQSYARIMNIKLETE

Output: Involved in lysis inhibition. Senses superinfections and inhibits the holin, thereby delaying the host cell lysis timing. The genomic DNA from the superinfecting phage bound to the complex holin-antiholin probably serves as a signal for the lysis inhibition and blocks the holin multimerization.


Instruction: Predict the functional description of the protein sequence below.

Input: MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI

Output: Plays a role in modulating the host immune response . May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increasing secretion of pro-inflammatory factors . Contributes to the cytokine storm during SARS-CoV-2 infection when secreted by unconventional pathway . May act by down-regulating major histocompability complex class I (MHC-I) at cell surface . May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 .


Instruction: Predict the general functional description of the protein sequence.

Output: [Glycoprotein N]: Forms the spikes present at the surface of the virion together with Glycoprotein C. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity). Plays a role in virus binding and/or entry into the vector midgut .;


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MQRVSRLKREMQLLTAEPPPGVSCWQSEGRLDELQAQIVGGANTPYEGGVFTLEINIPERYPFEPPKMRFLTPIYHPNIDNAGRICLDALKLPPKGAWRPSLNISTVLTSIQLLMAEPNPDDPLMADISSEFKYNKPLYLEKAKKWTAEHAIQKNKGCVETDGKTPENKNLKTSHKREALSAQENLEHTKKVCL

Output: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in DNA repair.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Predict the general functional description of the protein sequence.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: What is the functional description of the protein sequence?

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Can you provide the functional description of the following protein sequence?

Output: [Glycoprotein N]: Forms the spikes present at the surface of the virion together with Glycoprotein C. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity). Plays a role in virus binding and/or entry into the vector midgut (By similarity).;


Instruction: Predict the general functional description of the protein sequence.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: What is the functional description of the protein sequence?

Output: [Glycoprotein N]: Forms the spikes present at the surface of the virion together with Glycoprotein C. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity). Plays a role in virus binding and/or entry into the vector midgut (By similarity).;


Instruction: Predict the functional description of the protein sequence below.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.


Instruction: Predict the general functional description of the protein sequence.

Output: Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space . Determines the precise timing of host cell lysis . Regulated by specific antiholins that somehow sense superinfections and then delay lysis . Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Predict the functional description of the protein sequence below.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Predict the general functional description of the protein sequence.

Output: [Glycoprotein N]: Forms the spikes present at the surface of the virion together with Glycoprotein C. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity). Plays a role in virus binding and/or entry into the vector midgut (By similarity).;


Instruction: What is the functional description of the protein sequence?

Output: [Glycoprotein N]: Forms the spikes present at the surface of the virion together with Glycoprotein C. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity). Plays a role in virus binding and/or entry into the vector midgut (By similarity).;


Instruction: What is the functional description of the protein sequence?

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: What is the functional description of the protein sequence?

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Predict the functional description of the protein sequence below.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Predict the general functional description of the protein sequence.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Predict the functional description of the protein sequence below.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Glycosyl O-methyltransferase that catalyzes the final step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid that inhibits topoisomerase 1. Has broad substrate specificity and functions as glycosyl O-methyltransferase on a number of rebeccamycin analogs.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Input: MAARLMKEYKVLQNEEFEDILLYPRDESDLYRWVAIIKGPPDTPYENGKFELDISVPTNYPLQPPTIKFVTKIFHPNIHFKTGEICLDLLKTSWSAIYTLQSVCRSIIALLSLPEADSPLNCDAGNLIRNGDVKGHDSLARMYTRLYGC

Output: Catalyzes the covalent attachment of ubiquitin to other proteins. Essential for peroxisome biogenesis.


Instruction: What is the functional description of the protein sequence?

Output: May be tethered PEX4 to the peroxisome membrane and may be involved in a late step of the matrix protein import. Does not play a role in the biogenesis of the peroxisomal membrane.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).


Instruction: Predict the functional description of the protein sequence below.

Output: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.


Instruction: Predict the functional description of the protein sequence below.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.


Instruction: What is the functional description of the protein sequence?

Output: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.


Instruction: Can you provide the functional description of the following protein sequence?

Output: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).


Instruction: Can you provide the functional description of the following protein sequence?

Output: Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.


Instruction: What is the functional description of the protein sequence?

Input: MKKFIFATIFALASCAAQPAMAGYDKDLCEWSMTADQTEVETQIEADIMNIVKRDRPEMKAEVQKQLKSGGVMQYNYVLYCDKNFNNKNIIAEVVGE

Output: Inhibits viral DNA ejection into the host cytoplasm, thereby confering the infected host bacteria with immunity against secondary phage infection . Achieves superinfection exclusion by localizing to the periplasm and inhibiting the activity of tail-associated lysozyme, thereby preventing penetration by the tail tube of incoming phages .


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein OPG116. Serves as a bridge which links the DNA polymerase OPG071 and the uracil DNA glycosylase.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein OPG116. Serves as a bridge which links the DNA polymerase OPG071 and the uracil DNA glycosylase.


Instruction: What is the functional description of the protein sequence?

Output: Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Determines the precise timing of host cell lysis. Regulated by specific antiholins that somehow sense superinfections and then delay lysis. Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein OPG116 . Serves as a bridge which links the DNA polymerase OPG071 and the uracil DNA glycosylase .


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein OPG116. Serves as a bridge which links the DNA polymerase OPG071 and the uracil DNA glycosylase.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: What is the functional description of the protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Can you provide the functional description of the following protein sequence?

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the functional description of the protein sequence below.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Predict the general functional description of the protein sequence.

Output: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


Instruction: Generate the functional description in free-text form based on the protein sequence.

Output: Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein D4. May serve as a bridge which links the DNA polymerase E9 and the uracil DNA glycosylase (By similarity).